@datagrok/bio 2.21.7 → 2.21.8

package/dist/package.js

@@ -1,8 +1,8 @@
-var bio;(()=>{var t={8924:(t,e,n)=>{"use strict";var i=n(7362);class r extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in r.aaSynonyms?r.aaSynonyms[t]:t;return super.get(e)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(t="grok"){switch(t){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const r of t)"("==r?e++:")"==r?e--:e?n+=r:i+=r;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){const n=this.getPalette(e);let[i,r]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,r=r.length>6?`${r.slice(0,3)}...`:r,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in n?[n.get(e),e,r,1]:[this.undefinedColor,i,r,1]}if("d"==t[0]&&t[1]in n&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in n?[n.get(e),e,r,2]:[this.undefinedColor,i,r,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in n?[n.get(e),e,r,3]:[this.undefinedColor,i,r,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in n?[n.get(e),e,r,4]:[this.undefinedColor,i,r,4]}return[this.undefinedColor,i,r,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(t,e,n)=>{"use strict";n.d(e,{j:()=>r});var i=n(6082);async function r(){const t=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===t.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await t[0].prepare().call()).getOutputParamValue()}},3599:(t,e,n)=>{"use strict";n.d(e,{o:()=>i.o});var i=n(6869)},9124:(t,e,n)=>{"use strict";n.d(e,{b2:()=>o,fA:()=>s});var i=n(7389),r=n(6082);async function o(){const t="Helm",e=r.Func.find({package:t,name:"getHelmHelper"});if(0===e.length)throw new Error(`Package '${t}' must be installed for HelmHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}function s(t,e){if(!t)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const r=t;return"ATOM"===r.T?(n=r.biotype(),i=r.elem):(n=t,i=e),[n,i]}r.JsInputBase,Error,i.input.helmAsync=async function(t,e){return(await o()).createHelmInput(t,e)}},8438:(t,e,n)=>{"use strict";function i(t){return t.startsWith("[")&&t.endsWith("]")?t.slice(1,-1):t}n.d(e,{D:()=>i})},8123:(t,e,n)=>{"use strict";n.d(e,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(t,e,n)=>{"use strict";n.d(e,{Eu:()=>a,ub:()=>s});var i=n(4328);const r="Libraries";let o=Promise.resolve();async function s(){let t;return o=o.then((async()=>{const e=i.userSettings.getValue(r,"Settings",!0);t=e?JSON.parse(e):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},t.exclude=t.exclude instanceof Array?t.exclude:[],t.explicit=t.explicit instanceof Array?t.explicit:[],t.duplicateMonomerPreferences=t.duplicateMonomerPreferences instanceof Object?t.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await o,t}async function a(t){o=o.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),i.userSettings.add(r,"Settings",JSON.stringify(t),!0)})),await o}},5553:(t,e,n)=>{"use strict";n.d(e,{Qc:()=>A,WN:()=>S});var i=n(1991),r=n.n(i);const o="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(t,e,n,i)=>{"function"==typeof a.emitWarning?a.emitWarning(t,e,n,i):console.error(`[${n}] ${e}: ${t}`)};let c=globalThis.AbortController,h=globalThis.AbortSignal;if(void 0===c){h=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(t,e){this._onabort.push(e)}},c=class{constructor(){e()}signal=new h;abort(t){if(!this.signal.aborted){this.signal.reason=t,this.signal.aborted=!0;for(const e of this.signal._onabort)e(t);this.signal.onabort?.(t)}}};let t="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const e=()=>{t&&(t=!1,l("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). You may disable this with LRU_CACHE_IGNORE_AC_WARNING=1 in the env.","NO_ABORT_CONTROLLER","ENOTSUP",e))}}Symbol("type");const u=t=>t&&t===Math.floor(t)&&t>0&&isFinite(t),d=t=>u(t)?t<=Math.pow(2,8)?Uint8Array:t<=Math.pow(2,16)?Uint16Array:t<=Math.pow(2,32)?Uint32Array:t<=Number.MAX_SAFE_INTEGER?p:null:null;class p extends Array{constructor(t){super(t),this.fill(0)}}class m{heap;length;static#t=!1;static create(t){const e=d(t);if(!e)return[];m.#t=!0;const n=new m(t,e);return m.#t=!1,n}constructor(t,e){if(!m.#t)throw new TypeError("instantiate Stack using Stack.create(n)");this.heap=new e(t),this.length=0}push(t){this.heap[this.length++]=t}pop(){return this.heap[--this.length]}}class f{#e;#n;#i;#r;#o;#s;ttl;ttlResolution;ttlAutopurge;updateAgeOnGet;updateAgeOnHas;allowStale;noDisposeOnSet;noUpdateTTL;maxEntrySize;sizeCalculation;noDeleteOnFetchRejection;noDeleteOnStaleGet;allowStaleOnFetchAbort;allowStaleOnFetchRejection;ignoreFetchAbort;#a;#l;#c;#h;#u;#d;#p;#m;#f;#g;#y;#b;#v;#w;#C;#A;#S;static unsafeExposeInternals(t){return{starts:t.#v,ttls:t.#w,sizes:t.#b,keyMap:t.#c,keyList:t.#h,valList:t.#u,next:t.#d,prev:t.#p,get head(){return t.#m},get tail(){return t.#f},free:t.#g,isBackgroundFetch:e=>t.#x(e),backgroundFetch:(e,n,i,r)=>t.#E(e,n,i,r),moveToTail:e=>t.#M(e),indexes:e=>t.#_(e),rindexes:e=>t.#I(e),isStale:e=>t.#T(e)}}get max(){return this.#e}get maxSize(){return this.#n}get calculatedSize(){return this.#l}get size(){return this.#a}get fetchMethod(){return this.#o}get memoMethod(){return this.#s}get dispose(){return this.#i}get disposeAfter(){return this.#r}constructor(t){const{max:e=0,ttl:n,ttlResolution:i=1,ttlAutopurge:r,updateAgeOnGet:o,updateAgeOnHas:a,allowStale:c,dispose:h,disposeAfter:p,noDisposeOnSet:g,noUpdateTTL:y,maxSize:b=0,maxEntrySize:v=0,sizeCalculation:w,fetchMethod:C,memoMethod:A,noDeleteOnFetchRejection:S,noDeleteOnStaleGet:x,allowStaleOnFetchRejection:E,allowStaleOnFetchAbort:M,ignoreFetchAbort:_}=t;if(0!==e&&!u(e))throw new TypeError("max option must be a nonnegative integer");const I=e?d(e):Array;if(!I)throw new Error("invalid max value: "+e);if(this.#e=e,this.#n=b,this.maxEntrySize=v||this.#n,this.sizeCalculation=w,this.sizeCalculation){if(!this.#n&&!this.maxEntrySize)throw new TypeError("cannot set sizeCalculation without setting maxSize or maxEntrySize");if("function"!=typeof this.sizeCalculation)throw new TypeError("sizeCalculation set to non-function")}if(void 0!==A&&"function"!=typeof A)throw new TypeError("memoMethod must be a function if defined");if(this.#s=A,void 0!==C&&"function"!=typeof C)throw new TypeError("fetchMethod must be a function if specified");if(this.#o=C,this.#A=!!C,this.#c=new Map,this.#h=new Array(e).fill(void 0),this.#u=new Array(e).fill(void 0),this.#d=new I(e),this.#p=new I(e),this.#m=0,this.#f=0,this.#g=m.create(e),this.#a=0,this.#l=0,"function"==typeof h&&(this.#i=h),"function"==typeof p?(this.#r=p,this.#y=[]):(this.#r=void 0,this.#y=void 0),this.#C=!!this.#i,this.#S=!!this.#r,this.noDisposeOnSet=!!g,this.noUpdateTTL=!!y,this.noDeleteOnFetchRejection=!!S,this.allowStaleOnFetchRejection=!!E,this.allowStaleOnFetchAbort=!!M,this.ignoreFetchAbort=!!_,0!==this.maxEntrySize){if(0!==this.#n&&!u(this.#n))throw new TypeError("maxSize must be a positive integer if specified");if(!u(this.maxEntrySize))throw new TypeError("maxEntrySize must be a positive integer if specified");this.#L()}if(this.allowStale=!!c,this.noDeleteOnStaleGet=!!x,this.updateAgeOnGet=!!o,this.updateAgeOnHas=!!a,this.ttlResolution=u(i)||0===i?i:1,this.ttlAutopurge=!!r,this.ttl=n||0,this.ttl){if(!u(this.ttl))throw new TypeError("ttl must be a positive integer if specified");this.#N()}if(0===this.#e&&0===this.ttl&&0===this.#n)throw new TypeError("At least one of max, maxSize, or ttl is required");if(!this.ttlAutopurge&&!this.#e&&!this.#n){const t="LRU_CACHE_UNBOUNDED";(t=>!s.has(t))(t)&&(s.add(t),l("TTL caching without ttlAutopurge, max, or maxSize can result in unbounded memory consumption.","UnboundedCacheWarning",t,f))}}getRemainingTTL(t){return this.#c.has(t)?1/0:0}#N(){const t=new p(this.#e),e=new p(this.#e);this.#w=t,this.#v=e,this.#P=(n,i,r=o.now())=>{if(e[n]=0!==i?r:0,t[n]=i,0!==i&&this.ttlAutopurge){const t=setTimeout((()=>{this.#T(n)&&this.#$(this.#h[n],"expire")}),i+1);t.unref&&t.unref()}},this.#R=n=>{e[n]=0!==t[n]?o.now():0},this.#O=(r,o)=>{if(t[o]){const s=t[o],a=e[o];if(!s||!a)return;r.ttl=s,r.start=a,r.now=n||i();const l=r.now-a;r.remainingTTL=s-l}};let n=0;const i=()=>{const t=o.now();if(this.ttlResolution>0){n=t;const e=setTimeout((()=>n=0),this.ttlResolution);e.unref&&e.unref()}return t};this.getRemainingTTL=r=>{const o=this.#c.get(r);if(void 0===o)return 0;const s=t[o],a=e[o];return s&&a?s-((n||i())-a):1/0},this.#T=r=>{const o=e[r],s=t[r];return!!s&&!!o&&(n||i())-o>s}}#R=()=>{};#O=()=>{};#P=()=>{};#T=()=>!1;#L(){const t=new p(this.#e);this.#l=0,this.#b=t,this.#k=e=>{this.#l-=t[e],t[e]=0},this.#G=(t,e,n,i)=>{if(this.#x(e))return 0;if(!u(n)){if(!i)throw new TypeError("invalid size value (must be positive integer). When maxSize or maxEntrySize is used, sizeCalculation or size must be set.");if("function"!=typeof i)throw new TypeError("sizeCalculation must be a function");if(n=i(e,t),!u(n))throw new TypeError("sizeCalculation return invalid (expect positive integer)")}return n},this.#F=(e,n,i)=>{if(t[e]=n,this.#n){const n=this.#n-t[e];for(;this.#l>n;)this.#H(!0)}this.#l+=t[e],i&&(i.entrySize=n,i.totalCalculatedSize=this.#l)}}#k=t=>{};#F=(t,e,n)=>{};#G=(t,e,n,i)=>{if(n||i)throw new TypeError("cannot set size without setting maxSize or maxEntrySize on cache");return 0};*#_({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#f;this.#B(e)&&(!t&&this.#T(e)||(yield e),e!==this.#m);)e=this.#p[e]}*#I({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#m;this.#B(e)&&(!t&&this.#T(e)||(yield e),e!==this.#f);)e=this.#d[e]}#B(t){return void 0!==t&&this.#c.get(this.#h[t])===t}*entries(){for(const t of this.#_())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*rentries(){for(const t of this.#I())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*keys(){for(const t of this.#_()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*rkeys(){for(const t of this.#I()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*values(){for(const t of this.#_())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}*rvalues(){for(const t of this.#I())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}[Symbol.iterator](){return this.entries()}[Symbol.toStringTag]="LRUCache";find(t,e={}){for(const n of this.#_()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;if(void 0!==r&&t(r,this.#h[n],this))return this.get(this.#h[n],e)}}forEach(t,e=this){for(const n of this.#_()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;void 0!==r&&t.call(e,r,this.#h[n],this)}}rforEach(t,e=this){for(const n of this.#I()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;void 0!==r&&t.call(e,r,this.#h[n],this)}}purgeStale(){let t=!1;for(const e of this.#I({allowStale:!0}))this.#T(e)&&(this.#$(this.#h[e],"expire"),t=!0);return t}info(t){const e=this.#c.get(t);if(void 0===e)return;const n=this.#u[e],i=this.#x(n)?n.__staleWhileFetching:n;if(void 0===i)return;const r={value:i};if(this.#w&&this.#v){const t=this.#w[e],n=this.#v[e];if(t&&n){const e=t-(o.now()-n);r.ttl=e,r.start=Date.now()}}return this.#b&&(r.size=this.#b[e]),r}dump(){const t=[];for(const e of this.#_({allowStale:!0})){const n=this.#h[e],i=this.#u[e],r=this.#x(i)?i.__staleWhileFetching:i;if(void 0===r||void 0===n)continue;const s={value:r};if(this.#w&&this.#v){s.ttl=this.#w[e];const t=o.now()-this.#v[e];s.start=Math.floor(Date.now()-t)}this.#b&&(s.size=this.#b[e]),t.unshift([n,s])}return t}load(t){this.clear();for(const[e,n]of t){if(n.start){const t=Date.now()-n.start;n.start=o.now()-t}this.set(e,n.value,n)}}set(t,e,n={}){if(void 0===e)return this.delete(t),this;const{ttl:i=this.ttl,start:r,noDisposeOnSet:o=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#G(t,e,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#$(t,"set"),this;let h=0===this.#a?void 0:this.#c.get(t);if(void 0===h)h=0===this.#a?this.#f:0!==this.#g.length?this.#g.pop():this.#a===this.#e?this.#H(!1):this.#a,this.#h[h]=t,this.#u[h]=e,this.#c.set(t,h),this.#d[this.#f]=h,this.#p[h]=this.#f,this.#f=h,this.#a++,this.#F(h,c,a),a&&(a.set="add"),l=!1;else{this.#M(h);const n=this.#u[h];if(e!==n){if(this.#A&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:e}=n;void 0===e||o||(this.#C&&this.#i?.(e,t,"set"),this.#S&&this.#y?.push([e,t,"set"]))}else o||(this.#C&&this.#i?.(n,t,"set"),this.#S&&this.#y?.push([n,t,"set"]));if(this.#k(h),this.#F(h,c,a),this.#u[h]=e,a){a.set="replace";const t=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==t&&(a.oldValue=t)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(h,i,r),a&&this.#O(a,h)),!o&&this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}return this}pop(){try{for(;this.#a;){const t=this.#u[this.#m];if(this.#H(!0),this.#x(t)){if(t.__staleWhileFetching)return t.__staleWhileFetching}else if(void 0!==t)return t}}finally{if(this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}}}#H(t){const e=this.#m,n=this.#h[e],i=this.#u[e];return this.#A&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(i,n,"evict"),this.#S&&this.#y?.push([i,n,"evict"])),this.#k(e),t&&(this.#h[e]=void 0,this.#u[e]=void 0,this.#g.push(e)),1===this.#a?(this.#m=this.#f=0,this.#g.length=0):this.#m=this.#d[e],this.#c.delete(n),this.#a--,e}has(t,e={}){const{updateAgeOnHas:n=this.updateAgeOnHas,status:i}=e,r=this.#c.get(t);if(void 0!==r){const t=this.#u[r];if(this.#x(t)&&void 0===t.__staleWhileFetching)return!1;if(!this.#T(r))return n&&this.#R(r),i&&(i.has="hit",this.#O(i,r)),!0;i&&(i.has="stale",this.#O(i,r))}else i&&(i.has="miss");return!1}peek(t,e={}){const{allowStale:n=this.allowStale}=e,i=this.#c.get(t);if(void 0===i||!n&&this.#T(i))return;const r=this.#u[i];return this.#x(r)?r.__staleWhileFetching:r}#E(t,e,n,i){const r=void 0===e?void 0:this.#u[e];if(this.#x(r))return r;const o=new c,{signal:s}=n;s?.addEventListener("abort",(()=>o.abort(s.reason)),{signal:o.signal});const a={signal:o.signal,options:n,context:i},l=(i,r=!1)=>{const{aborted:s}=o.signal,l=n.ignoreFetchAbort&&void 0!==i;if(n.status&&(s&&!r?(n.status.fetchAborted=!0,n.status.fetchError=o.signal.reason,l&&(n.status.fetchAbortIgnored=!0)):n.status.fetchResolved=!0),s&&!l&&!r)return h(o.signal.reason);const c=u;return this.#u[e]===u&&(void 0===i?c.__staleWhileFetching?this.#u[e]=c.__staleWhileFetching:this.#$(t,"fetch"):(n.status&&(n.status.fetchUpdated=!0),this.set(t,i,a.options))),i},h=i=>{const{aborted:r}=o.signal,s=r&&n.allowStaleOnFetchAbort,a=s||n.allowStaleOnFetchRejection,l=a||n.noDeleteOnFetchRejection,c=u;if(this.#u[e]===u&&(l&&void 0!==c.__staleWhileFetching?s||(this.#u[e]=c.__staleWhileFetching):this.#$(t,"fetch")),a)return n.status&&void 0!==c.__staleWhileFetching&&(n.status.returnedStale=!0),c.__staleWhileFetching;if(c.__returned===c)throw i};n.status&&(n.status.fetchDispatched=!0);const u=new Promise(((e,i)=>{const s=this.#o?.(t,r,a);s&&s instanceof Promise&&s.then((t=>e(void 0===t?void 0:t)),i),o.signal.addEventListener("abort",(()=>{n.ignoreFetchAbort&&!n.allowStaleOnFetchAbort||(e(void 0),n.allowStaleOnFetchAbort&&(e=t=>l(t,!0)))}))})).then(l,(t=>(n.status&&(n.status.fetchRejected=!0,n.status.fetchError=t),h(t)))),d=Object.assign(u,{__abortController:o,__staleWhileFetching:r,__returned:void 0});return void 0===e?(this.set(t,d,{...a.options,status:void 0}),e=this.#c.get(t)):this.#u[e]=d,d}#x(t){if(!this.#A)return!1;const e=t;return!!e&&e instanceof Promise&&e.hasOwnProperty("__staleWhileFetching")&&e.__abortController instanceof c}async fetch(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:r=this.noDeleteOnStaleGet,ttl:o=this.ttl,noDisposeOnSet:s=this.noDisposeOnSet,size:a=0,sizeCalculation:l=this.sizeCalculation,noUpdateTTL:c=this.noUpdateTTL,noDeleteOnFetchRejection:h=this.noDeleteOnFetchRejection,allowStaleOnFetchRejection:u=this.allowStaleOnFetchRejection,ignoreFetchAbort:d=this.ignoreFetchAbort,allowStaleOnFetchAbort:p=this.allowStaleOnFetchAbort,context:m,forceRefresh:f=!1,status:g,signal:y}=e;if(!this.#A)return g&&(g.fetch="get"),this.get(t,{allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:r,status:g});const b={allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:r,ttl:o,noDisposeOnSet:s,size:a,sizeCalculation:l,noUpdateTTL:c,noDeleteOnFetchRejection:h,allowStaleOnFetchRejection:u,allowStaleOnFetchAbort:p,ignoreFetchAbort:d,status:g,signal:y};let v=this.#c.get(t);if(void 0===v){g&&(g.fetch="miss");const e=this.#E(t,v,b,m);return e.__returned=e}{const e=this.#u[v];if(this.#x(e)){const t=n&&void 0!==e.__staleWhileFetching;return g&&(g.fetch="inflight",t&&(g.returnedStale=!0)),t?e.__staleWhileFetching:e.__returned=e}const r=this.#T(v);if(!f&&!r)return g&&(g.fetch="hit"),this.#M(v),i&&this.#R(v),g&&this.#O(g,v),e;const o=this.#E(t,v,b,m),s=void 0!==o.__staleWhileFetching&&n;return g&&(g.fetch=r?"stale":"refresh",s&&r&&(g.returnedStale=!0)),s?o.__staleWhileFetching:o.__returned=o}}async forceFetch(t,e={}){const n=await this.fetch(t,e);if(void 0===n)throw new Error("fetch() returned undefined");return n}memo(t,e={}){const n=this.#s;if(!n)throw new Error("no memoMethod provided to constructor");const{context:i,forceRefresh:r,...o}=e,s=this.get(t,o);if(!r&&void 0!==s)return s;const a=n(t,s,{options:o,context:i});return this.set(t,a,o),a}get(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:r=this.noDeleteOnStaleGet,status:o}=e,s=this.#c.get(t);if(void 0!==s){const e=this.#u[s],a=this.#x(e);return o&&this.#O(o,s),this.#T(s)?(o&&(o.get="stale"),a?(o&&n&&void 0!==e.__staleWhileFetching&&(o.returnedStale=!0),n?e.__staleWhileFetching:void 0):(r||this.#$(t,"expire"),o&&n&&(o.returnedStale=!0),n?e:void 0)):(o&&(o.get="hit"),a?e.__staleWhileFetching:(this.#M(s),i&&this.#R(s),e))}o&&(o.get="miss")}#D(t,e){this.#p[e]=t,this.#d[t]=e}#M(t){t!==this.#f&&(t===this.#m?this.#m=this.#d[t]:this.#D(this.#p[t],this.#d[t]),this.#D(this.#f,t),this.#f=t)}delete(t){return this.#$(t,"delete")}#$(t,e){let n=!1;if(0!==this.#a){const i=this.#c.get(t);if(void 0!==i)if(n=!0,1===this.#a)this.#V(e);else{this.#k(i);const n=this.#u[i];if(this.#x(n)?n.__abortController.abort(new Error("deleted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(n,t,e),this.#S&&this.#y?.push([n,t,e])),this.#c.delete(t),this.#h[i]=void 0,this.#u[i]=void 0,i===this.#f)this.#f=this.#p[i];else if(i===this.#m)this.#m=this.#d[i];else{const t=this.#p[i];this.#d[t]=this.#d[i];const e=this.#d[i];this.#p[e]=this.#p[i]}this.#a--,this.#g.push(i)}}if(this.#S&&this.#y?.length){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}return n}clear(){return this.#V("delete")}#V(t){for(const e of this.#I({allowStale:!0})){const n=this.#u[e];if(this.#x(n))n.__abortController.abort(new Error("deleted"));else{const i=this.#h[e];this.#C&&this.#i?.(n,i,t),this.#S&&this.#y?.push([n,i,t])}}if(this.#c.clear(),this.#u.fill(void 0),this.#h.fill(void 0),this.#w&&this.#v&&(this.#w.fill(0),this.#v.fill(0)),this.#b&&this.#b.fill(0),this.#m=0,this.#f=0,this.#g.length=0,this.#l=0,this.#a=0,this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}}}function g(t){window.$monomerHover=t}var y=n(2003),b=n(6077),v=n(3561),w=n(9235);const C="MonomerHoverLinks";async function A(t,e,n,i,o,s=!1){const a=i.getSeqHandler(t),l=a.alphabet==y.YI.RNA||a.alphabet==y.YI.DNA,c=a.isHelm()&&l,h=!a.isHelm()&&l,u=t=>null==t?null:c?s?t:Math.floor(t/3):h&&s?3*t+1:t,d=s?await i.getHelmToMolfileConverter(n):null,p=new f({max:100});function m(t,e){const a=t.get(e);if(null==a)return null;let l=p.get(a);return l||p.set(a,l=function(t,e){const a=i.getSeqHandler(t);if(s){const t=a.getHelm(e);return i.helmToAtomicLevelSingle(t,d,!1,!1).monomers}{const t=a.getSplitted(e),i=a.defaultBiotype,s=r().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:i}))).toArray(),l=a.alphabet,c=l==y.YI.RNA||l==y.YI.DNA?"RNA":"PEPTIDE",h=(0,b.eM)([s],c,l,n,o);return(0,v.gU)(s,h,l,c).monomers}}(t,e)),l}const A={targetCol:e,handler:(e,i,r)=>{const o=r.grid,s=e.tableRowIndex,a=e.gridRow,l=o.cell(r.name,a),c=null!==(h=window.$monomerHover)&&void 0!==h?h:null;var h;if(!c||c&&(c.dataFrameId!=t.dataFrame.id||c.gridRowIdx!=a||c.seqColName!=t.name||c.seqPosition!=i?.position)){if(c&&(g(null),c.gridCell.render()),!i)return g(null),!0;g({gridCell:l,dataFrameId:t.dataFrame.id,gridRowIdx:a,seqColName:t.name,seqPosition:u(i?.position)??-1,getSubstruct:()=>{if(!i||"*"===i.symbol)return;const e=m(t,s);if(!e)return;const r=e.get(u(i?.position));return r?(0,w.H)([r],n):{atoms:[],bonds:[],highlightAtomColors:[],highlightBondColors:[]}}}),l.render()}return!0},getSubstruct:i=>{if("true"!=e.getTag(".sequence-src-highlight-monomers"))return;if(null==i)return;if(!t.get(i))return;const r=m(t,i);return r?(0,w.H)(r.values(),n):void 0}};return function(t,e){let n=t[C];n||(n=t[C]=[]),n.push(e),t[C]=n}(t.temp,A),function(t,e){let n=t["substruct-providers"];n||(n=t["substruct-providers"]=[]),n.push(e),t["substruct-providers"]=n}(e.temp,A),A}function S(t,e){try{const n=t.tableColumn;if(!n)return;const i=function(t){return t.temp[C]??[]}(n);for(let n=i.length-1;n>=0;--n){const r=i[n],o=t.grid.col(r.targetCol.name);if(o&&!r.handler(t,e,o))break}}catch(t){console.error(t)}}},6718:(t,e,n)=>{"use strict";n.d(e,{A7:()=>p,pj:()=>h,uL:()=>u,uX:()=>c});var i=n(6082),r=n(4328),o=n(6295),s=n(3151),a=n(3077),l=n(439);function c(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(s.Ec).forEach((e=>{if("symbol"===e){const r=t.get(s.Ec[e],n);i[e]="."===r?t.get(s.yw,n):r}else if("rgroups"===e){const r=t.get(s.Ec[e],n).split("\n"),o=[];r.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else s.Ec[e]&&(i[e]=t.get(s.Ec[e],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),e.push(i)}return e}async function h(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e,n){t instanceof i.Column&&(t=(0,a.R)(t,n).columns.toList());const o=(await h()).getMonomerLib(),s=new Array(t.length),c=t[0].length,u=new Float32Array(c);for(let n=0;n<t.length;++n){const a=n<e.length?e.getCanonical(n):l._S,h=o.getMonomer("PEPTIDE",a)?.smiles??"",d=t[n],p=d.getRawData(),m=d.categories,f=m.indexOf("");if(s[n]={categories:m,data:p,emptyIndex:f},void 0===a)continue;const g=i.Column.fromStrings("smiles",m.map((t=>o.getMonomer("PEPTIDE",t)?.smiles??""))),y=(i.DataFrame.fromColumns([g]),await r.chem.getSimilarities(g,h)),b=y?y.getRawData():null;for(let t=0;t<c;++t){const e=p[t];a!==l._S&&e!==f?u[t]+=b[e]:a===l._S&&e===f&&(u[t]+=1)}}for(let n=0;n<u.length;++n){let r=u[n]/e.length;for(let o=0;o<t.length;++o){const t=s[o];if(o>=e.length&&t.data[n]!==t.emptyIndex||t.data[n]===t.emptyIndex&&o<e.length){r=i.FLOAT_NULL;break}}u[n]=r}return i.Column.fromFloat32Array("Similarity",u)}async function d(t){const e=(await h()).getMonomerLib(),n=[],o={},s=t.map((t=>e.getMonomer("PEPTIDE",t)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let e=0;e<s.length;++e){o[t[e]]=e;const i=s[e],l=""===i?new Array(s.length).fill(0):(await r.chem.getSimilarities(a,i)).getRawData();l[e]=1,n[e]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:o}}async function p(t,e="Morgan"){const n=(await h()).getMonomerLib(),r=new Array(t.length).fill(0).map((()=>new Array(t.length).fill(0))),s={},a=t.map((t=>n.getMonomer("PEPTIDE",t)?.molfile||n.getMonomer("PEPTIDE",t)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(t);const c=i.Column.fromStrings("smiles",a),u=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:e}))?.entries);if(!u)return console.warn(`${e} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await d(t);for(let e=0;e<u.length;++e)if(r[e][e]=1,s[t[e]]=e,u[e])for(let t=e+1;t<u.length;++t)u[t]&&(r[e][t]=r[t][e]=(0,o.$1)(u[e],u[t]));return{scoringMatrix:r,alphabetIndexes:s}}},6197:(t,e,n)=>{"use strict";n.d(e,{Y:()=>r});var i=n(3599);function r(t){let e;switch(t){case i.o.BASE:case i.o.SUGAR:case i.o.LINKER:case i.o.NUCLEOTIDE:case"nucleotide":e="RNA";break;case i.o.AA:e="PEPTIDE";break;case i.o.CHEM:e="CHEM";break;case i.o.BLOB:e="BLOB";break;default:e="PEPTIDE",console.warn(`Unexpected HelmType '${t}'`)}return e}},9235:(t,e,n)=>{"use strict";n.d(e,{H:()=>c,R:()=>l});var i=n(6082),r=n(1991),o=n.n(r),s=n(330),a=n(3599);async function l(t,e,r,l,c,h,u){const d=t.length,p=t.dataFrame,m=Math.max(navigator.hardwareConcurrency-2,1),f=new Array(m).fill(null).map((()=>new Worker(new URL(n.p+n.u(455),n.b)))),g=d/m,y=new Array(m),b=h.getSeqHandler(t),v="RNA"==l?a.o.NUCLEOTIDE:a.o.AA,w=o().count(0).take(t.length).map((t=>{const e=b.getSplitted(t);return o().count(0).take(e.length).map((t=>({position:t,symbol:e.getCanonical(t),biotype:v}))).toArray()})).toArray();for(let t=0;t<m;t++){const n=f[t],i=Math.floor(t*g),o=t===m-1?d:Math.floor((t+1)*g);y[t]=new Promise((t=>{n.onmessage=e=>{t(e.data)}})),n.postMessage({seqList:w,monomersDict:e,alphabet:r,polymerType:l,start:i,end:o})}const C=[],A=[];await Promise.all(y).then((t=>{for(const e of t)C.push(...e.molfiles),A.push(...e.warnings)})),setTimeout((()=>{f.forEach((t=>{t.terminate()}))}),0);const S=(0,s.qj)(p,t.name),x=i.Column.fromType(i.COLUMN_TYPE.STRING,S,t.length).init((t=>C[t]?.molfile));return x.semType=i.SEMTYPE.MOLECULE,x.meta.units=i.UNITS.Molecule.MOLBLOCK,x.setTag(".sequence-src-col",t.name),{molCol:x,warnings:A}}function c(t,e){const n={},r={};for(const o of t){const t=e.getWebEditorMonomer(o.biotype,o.symbol).backgroundcolor,a=(0,s.vG)(t??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const t of o.atoms)n[t]=a;for(const t of o.bonds)r[t]=a}return{atoms:Object.keys(n).map((t=>parseInt(t))),bonds:Object.keys(r).map((t=>parseInt(t))),highlightAtomColors:n,highlightBondColors:r}}},3561:(t,e,n)=>{"use strict";n.d(e,{Hb:()=>l,YN:()=>f,gU:()=>c});var i=n(8123),r=n(294),o=n(3151),s=n(439),a=n(6197);function l(t,e,n){const r=new Map;for(const a of t.getMonomerSymbolsByType(e)){const l=t.getMonomer(e,a);if("RNA"===e&&("Branch"===l.monomerType||n===s.YI.DNA&&l.symbol===i.u.DEOXYRIBOSE.symbol||n===s.YI.RNA&&l.symbol===i.u.RIBOSE.symbol||l.symbol===i.u.PHOSPHATE.symbol)||"PEPTIDE"===e&&"Branch"!==l.monomerType){const t={};o.f6.forEach((e=>{t[e]=l[e]})),r.set(l.symbol,t)}}return r}function c(t,e,n,o){if(0===t.length)return r.vF.createEmpty();const l=m,{atomCount:c,bondCount:u,needsCapping:p}=l(t,e,n,o),g=new Array(c),y=new Array(u);let b,v=null,w=null;"PEPTIDE"===o?b=h:(b=d,v=n===s.YI.DNA?(0,r.xb)(e,i.u.DEOXYRIBOSE):(0,r.xb)(e,i.u.RIBOSE),w=(0,r.xb)(e,i.u.PHOSPHATE));const C={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},A={sugar:v,phosphate:w,seqLength:t.length,atomCount:c,bondCount:u},S=new r.Cg,x=[];let E=0;for(C.i=0;C.i<A.seqLength;++C.i){const n=t[C.i];if(n.symbol===s._S)continue;const i=(0,r.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),o=C.nodeShift,l=C.bondShift;b(i,g,y,C,A),i.stereoAtoms?.forEach((t=>x.push(t+E))),E+=i.atoms.x.length;const c=C.nodeShift-o,h=new Array(c);for(let t=0;t<c;++t)h[t]=o+t;const u=C.bondShift-l,d=new Array(u);for(let t=0;t<u;++t)d[t]=l+t;S.set(C.i,{biotype:n.biotype,symbol:n.symbol,atoms:h,bonds:d})}p&&function(t,e,n,r){const o=n.nodeShift+1;t[r.atomCount]=i.u.V3K_BEGIN_DATA_LINE+o+" "+i.u.OXYGEN+" "+f(n.backbonePositionShift[0])+" "+n.flipFactor*f(n.backbonePositionShift[1])+" 0.000000 0\n";const s=n.backboneAttachNode,a=o;e[r.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+s+" "+a+"\n"}(g,y,C,A);const M=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+u+i.u.V3K_COUNTS_LINE_ENDING;let _="";return _+=i.u.V3K_HEADER_FIRST_LINE,_+=i.u.V3K_HEADER_SECOND_LINE,_+=i.u.V3K_BEGIN_CTAB_BLOCK,_+=M,_+=i.u.V3K_BEGIN_ATOM_BLOCK,_+=g.join(""),_+=i.u.V3K_END_ATOM_BLOCK,_+=i.u.V3K_BEGIN_BOND_BLOCK,_+=y.join(""),_+=i.u.V3K_END_BOND_BLOCK,x.length>0&&(_+=function(t){const e=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${t.length}`;for(let i=0;i<t.length;i++){const r=`${n} ${t[i]}`;r.length>76?(e.push(`${n} -\n`),n=`M  V30 ${t[i]}`):n=r,i===t.length-1&&e.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${e.join("")}M  V30 END COLLECTION\n`}(x)),_+=i.u.V3K_END_CTAB_BLOCK,_+=i.u.V3K_END,{molfile:_,monomers:S}}function h(t,e,n,i){i.flipFactor=(-1)**(i.i%2),u(t,e,n,i)}function u(t,e,n,r){!function(t,e,n){for(let r=0;r<t.atoms.atomTypes.length;++r){const o=n.nodeShift+r+1;e[n.nodeShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.atoms.atomTypes[r]+" "+f(n.backbonePositionShift[0]+t.atoms.x[r])+" "+f(n.backbonePositionShift[1]+n.flipFactor*t.atoms.y[r])+" "+t.atoms.kwargs[r]}}(t,e,r),p(t,n,r),function(t,e,n){if(0!==n.backboneAttachNode){const r=n.bondShift,o=n.backboneAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+o+" "+s+"\n"}}(t,n,r),null!==t.meta.branchShift&&t.meta.terminalNodes.length>2&&function(t,e){e.branchAttachNode=e.nodeShift+t.meta.terminalNodes[2];for(let n=0;n<2;++n)e.branchPositionShift[n]=e.backbonePositionShift[n]+t.meta.branchShift[n]}(t,r),function(t,e){e.backboneAttachNode=e.nodeShift+t.meta.terminalNodes[1],e.bondShift+=t.bonds.atomPairs.length+1,e.nodeShift+=t.atoms.atomTypes.length,e.backbonePositionShift[0]+=t.meta.backboneShift?.[0]??0,e.backbonePositionShift[1]+=e.flipFactor*(t.meta.backboneShift?.[1]??0)}(t,r)}function d(t,e,n,r,o){if(0===r.i)u(o.sugar,e,n,r);else for(const t of[o.phosphate,o.sugar])u(t,e,n,r);!function(t,e,n,r){(function(t,e,n){for(let r=0;r<t.atoms.atomTypes.length;++r){const o=n.nodeShift+r+1;e[n.nodeShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.atoms.atomTypes[r]+" "+f(n.branchPositionShift[0]+t.atoms.x[r])+" "+f(n.branchPositionShift[1]+n.flipFactor*t.atoms.y[r])+" "+t.atoms.kwargs[r]}})(t,e,r),p(t,n,r),function(t,e,n){const r=n.bondShift,o=n.branchAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[r-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+o+" "+s+"\n"}(t,n,r);const o=r.bondShift,s=r.branchAttachNode,a=t.meta.terminalNodes[0]+r.nodeShift;n[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+a+"\n",r.bondShift+=t.bonds.atomPairs.length+1,r.nodeShift+=t.atoms.atomTypes.length}(t,e,n,r)}function p(t,e,n){for(let r=0;r<t.bonds.atomPairs.length;++r){const o=n.bondShift+r+1,s=t.bonds.atomPairs[r][0]+n.nodeShift,a=t.bonds.atomPairs[r][1]+n.nodeShift;let l="";if(t.bonds.bondConfiguration.has(r)){let e=t.bonds.bondConfiguration.get(r);n.flipFactor<0&&(e=1===e?3:1),l=" CFG="+e}const c=t.bonds.kwargs.has(r)?" "+t.bonds.kwargs.get(r):"";e[n.bondShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.bonds.bondTypes[r]+" "+s+" "+a+l+c+"\n"}}function m(t,e,n,o){let l=0,c=0,h=0,u=!0,d=null;for(const n of t)if(n.symbol!==s._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,r.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,h++}if("PEPTIDE"===o)l+=1,c+=h,h>0&&(d?.meta?.rNodes?.length??0)<2&&(u=!1,l-=1,c-=1);else{const o=n===s.YI.DNA?(0,r.xb)(e,i.u.DEOXYRIBOSE):(0,r.xb)(e,i.u.RIBOSE),a=(0,r.xb)(e,i.u.PHOSPHATE);l+=(t.length-1)*a.atoms.x.length,l+=t.length*o.atoms.x.length,l+=1,c+=(t.length-1)*a.bonds.bondTypes.length,c+=t.length*o.bonds.bondTypes.length,c-=1,c+=3*t.length}return{atomCount:l,bondCount:c,needsCapping:u}}function f(t){return Math.round(i.u.PRECISION_FACTOR*t)/i.u.PRECISION_FACTOR}},6077:(t,e,n)=>{"use strict";n.d(e,{C4:()=>m,eM:()=>f});var i=n(4328),r=n(6082),o=n(1991),s=n.n(o),a=n(439),l=n(3561),c=n(9235),h=n(294),u=n(9192),d=n(330),p=n(8123);async function m(t,e,n,o,l){if(e.semType!==r.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let h=e;const p=o.getSeqHandler(e);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=e.name);try{g=o.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(t){const[e,n]=(0,u.AP)(t);return{molCol:null,warnings:[e]}}const y=function(t,e){const n=t.length,r=new Array(n),o=e.getSeqHandler(t);let a=!1;const l=o.defaultBiotype;for(let t=0;t<n;++t){const e=o.getSplitted(t);a||(a=0===e.length),r[t]=s().count(0).take(e.length).filter((t=>!e.isGap(t))).map((t=>({position:t,biotype:l,symbol:e.getCanonical(t)}))).toArray()}return a&&i.shell.warning(`Some values in the "${t.name}" column are empty`),r}(h,o),b=f(y,m,g,n,l),v=h.length,w=await(0,c.R)(h,b,g,m,n,o,l);return w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`),w}function f(t,e,n,i,r){const o=(0,l.Hb)(i,e,n),s={},c={value:null};if("RNA"===e){const t=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of t)g(s,n.symbol,o,r,e,c)}for(let n=0;n<t.length;++n){const i=t[n];for(const t of i){const n=t.symbol;if(""!==n)try{if("RNA"===e&&3===n.split(/\(|\)/).filter((t=>!!t)).length){const t=n.split(/\(|\)/)[1];g(s,t,o,r,e,c),s[e]?.[t]&&(s[e][n]=s[e][t])}else g(s,n,o,r,e,c)}catch(t){const e=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${e}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${e}`)}}}return s}function g(t,e,n,i,r,o){const s={polymerType:r,symbol:e};if(!(0,h.bq)(t,s)){const a=function(t,e,n,i,r){if(e.has(t)){const s=e.get(t),a=function(t){const e=[];for(const n of t){let t=n.capGroupSmiles;t||(t=n.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,"").replace("OH","O").replace("Oh","O"),e.push(t)}return e}(s.rgroups),c=(o=s.molfile).includes("V3000")?function(t){const e=new Map,n=/M  V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(t));)i.index===n.lastIndex&&n.lastIndex++,e.set(parseInt(i[1]),parseInt(i[3]));return e}(o):function(t){const e=new Map;let n=t.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=t.indexOf("\n",n);const r=parseInt(t.substring(n,i).replace(/^A\s+/,""));n=t.indexOf("R",i),i=t.indexOf("\n",n);const o=parseInt(t.substring(n,i).replace(/^R/,""));e.set(r,o),n=t.indexOf(p.u.V2K_A_LINE,i)}for(n=t.indexOf(p.u.V2K_RGP_LINE,0),i=t.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=t.indexOf("\n",n);const r=t.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<r.length;t+=2){if(e.has(r[t])&&e.get(r[t])!==r[t+1])throw new Error(`r-group index ${r[t]} has already been added with a different value`);e.set(r[t],r[t+1])}n=t.indexOf(p.u.V2K_RGP_LINE,i)}return e}(o),h=s.molfile.includes("V3000")?s.molfile:function(t,e){const n=e.get_mol(function(t){return t.split("\n").map((t=>{const e=t.indexOf(" R#  "),n=t.indexOf(" R   ");if(-1===e&&-1===n)return t;const i=-1!==e?e:n,r=t.split("");for(let t=i+5;t<r.length;t++)" "!==r[t]&&(r[t]="0");return r.join("")})).join("\n")}(t)),i=n.get_v3Kmolblock();return n.delete(),i}(function(t){let e=t.indexOf(p.u.V2K_A_LINE,0);-1===e&&(e=t.indexOf(p.u.V2K_RGP_LINE));const n=t.indexOf(p.u.V3K_END,e);return t.substring(0,e)+t.substring(n)}(s.molfile),n),u=function(t){let e=(t=t.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,n));return e=n+1,n=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,n))}}(h),d=function(t,e){const n=new Array(e),i=new Float32Array(e),r=new Float32Array(e),o=new Array(e);let s=t.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;l++){s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,s)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s),s=a+1,a=t.indexOf(" ",s),n[l]=t.substring(s,a);const e=new Array(2);for(let n=0;n<2;++n)s=a+1,a=t.indexOf(" ",s),e[n]=parseFloat(t.substring(s,a));i[l]=e[0],r[l]=e[1],s=a,a=t.indexOf("\n",s)+1,o[l]=t.slice(s,a),s=a}return{atomTypes:n,x:i,y:r,kwargs:o}}(h,u.atomCount),m=function(t,e){const n=new Uint32Array(e),i=new Array(e),r=new Map,o=new Map;let s=t.indexOf(p.u.V3K_BEGIN_BOND_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;++l){const e=new Array(3);s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,a)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(t.indexOf("\n",s),t.indexOf(" ",s)),e[n]=parseInt(t.slice(s,a));n[l]=e[0],i[l]=e.slice(1);const c=t.indexOf("\n",s);let h=t.slice(a,c),u=h.indexOf(p.u.V3K_BOND_CONFIG);if(-1!==u){u=h.indexOf("=",u)+1;let t=h.indexOf(" ",u);-1===t&&(t=h.length);const e=parseInt(h.slice(u,t));r.set(l,e);const n=p.u.V3K_BOND_CONFIG+e.toString();h=h.replace(n,"")}h||o.set(l,h)}return{bondTypes:n,atomPairs:i,bondConfiguration:r,kwargs:o}}(h,u.bondCount),f=function(t,e,n,i){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(t,e,n){for(const[i,r]of n)t.atomTypes[i-1]=e[r-1]}(t,n,i),function(t,e){e.rNodes=Array.from(t.keys());for(let n=0;n<e.rNodes.length;n++)for(const i of[1,2])if(t.get(e.rNodes[n])===i){const t=e.rNodes[i-1];e.rNodes[i-1]=e.rNodes[n],e.rNodes[n]=t}}(i,r),y(e,r),r}(d,m,a,c),g=function(t){let e=[],n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=t.indexOf(")",n);e=e.concat(t.substring(n,i).split(" ").slice(1).map((t=>parseInt(t)))),n=i,n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(",n)}return e}(h),v={atoms:d,bonds:m,meta:f,stereoAtoms:g};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,r=t.atoms.y;M(t,-i[e],-r[e]);const o=A(i[n],r[n]);S(t.atoms,-o),i[t.meta.rNodes[1]-1]<0&&x(t);const s=function(t){const e=function(t){const e=new Map;for(const n of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=n[t],r=n[(t+1)%2];e.has(i)?e.get(i)?.push(r):e.set(i,new Array(1).fill(r))}return e}(t);let n=0;const i=t.atoms.atomTypes.length;let r=0;if(t.meta.terminalNodes.length<2)return null;for(;0===n;){const o=e.get(t.meta.terminalNodes[1])[r];if(t.atoms.atomTypes[o-1]===p.u.OXYGEN&&o!==t.meta.rNodes[1]&&(n=o),r++,r>i)return null}return n}(t);null!=s&&(function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){E(t,!0)}(t),S(t.atoms,-function(t,e){return A(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,s),function(t,e){const n=t.atoms.x;n[t.meta.rNodes[1]-1]>n[e-1]&&function(t,e,n){const i=e-1,r=n-1,o=t.atoms.x,s=t.atoms.y,a=o[i],l=s[i];o[i]=o[r],s[i]=s[r],o[r]=a,s[r]=l}(t,e,t.meta.rNodes[1])}(t,s))}(v):t===p.u.RIBOSE.symbol||t===p.u.DEOXYRIBOSE.symbol?function(t,e){const n=t.atoms.x,i=t.atoms.y;let r=t.meta.terminalNodes[0]-1;const o=t.meta.rNodes[1]-1;M(t,-n[r],-i[r]);const s=A(n[t.meta.rNodes[2]-1],i[t.meta.rNodes[2]-1]);S(t.atoms,-s),n[t.meta.rNodes[0]-1]>n[t.meta.rNodes[1]-1]&&x(t);const a=A(n[o],i[o]);S(t.atoms,3*Math.PI/2-a),e.value=function(t){const e=t.atoms.x,n=t.atoms.y,i=t.meta.rNodes[2]-1,r=t.meta.terminalNodes[2]-1,o=e[i]-e[r],s=n[i]-n[r];return Math.atan2(o,s)}(t),r=t.meta.terminalNodes[0]-1,M(t,-n[r],-i[r])}(v,r):t===p.u.PHOSPHATE.symbol?function(t){const e=t.meta.rNodes[1]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,r=t.atoms.y;M(t,-i[e],-r[e]);const o=A(i[n],r[n]);S(t.atoms,Math.PI/2-o)}(v):function(t,e){const n=t.atoms.x,i=t.atoms.y,r=t.meta.terminalNodes[0]-1,o=t.meta.rNodes[0]-1;M(t,-n[r],-i[r]);const s=A(n[o],i[o]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(t.atoms,Math.PI-s+a);const c=function(t,e){return(0,l.YN)(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:n[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:n[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=c)for(let t=0;t<n.length;++t)n[t]=(0,l.YN)(n[t]/c),i[t]=(0,l.YN)(i[t]/c)}(v,r),function(t,e,n){"PEPTIDE"===t?(b(e,t),w(e,e.meta.rNodes[1])):n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),b(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],M(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),b(e,t),w(e,e.meta.rNodes[1]))}(i,v,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===p.u.HYDROGEN&&(w(t,e+1),--e),++e}(v),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)"oh"===t.atoms.atomTypes[e]?.toLowerCase()&&(t.atoms.atomTypes[e]="O"),"?"===t.atoms.atomTypes[e]&&(t.atoms.atomTypes[e]="H"),++e}(v),function(t){const e=" RGROUPS=(1 1)";for(let n=0;n<(t.atoms.kwargs?.length??0);n++){const i=t.atoms.kwargs[n];i&&i.includes(e)&&(t.atoms.kwargs[n]=i.replace(e,""))}}(v),v}var o;return null}(e,n,i,r,o);if(!a)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);(0,h.LQ)(t,s,a)}}function y(t,e){const n=e.rNodes;e.terminalNodes=new Array(n.length).fill(0);const i=e.terminalNodes,r=t.atomPairs;let o=0,s=0;for(;o<r.length&&s<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)r[o][e]===n[t]&&(i[t]=r[o][(e+1)%2],n.length,++s);++o}}function b(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=v(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=v(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function v(t,e,n){return[(0,l.YN)(t.atoms.x[e]-t.atoms.x[n]),(0,l.YN)(t.atoms.y[e]-t.atoms.y[n])]}function w(t,e){if(void 0!==e){const n=e-1,i=t.atoms,r=t.bonds,o=t.meta;i.atomTypes.splice(n,1),i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let t=0;t<o.terminalNodes.length;++t)o.terminalNodes[t]>e?--o.terminalNodes[t]:o.terminalNodes[t]===e&&(o.terminalNodes[t]=-1);for(let t=0;t<o.rNodes.length;++t)o.rNodes[t]>e?--o.rNodes[t]:o.rNodes[t]===e&&(o.rNodes[t]=-1);let s=0;for(;s<r.atomPairs.length;){const t=r.atomPairs[s][0],n=r.atomPairs[s][1];t===e||n===e?(r.atomPairs.splice(s,1),r.bondTypes=C(Uint32Array,r.bondTypes,s,1),r.bondConfiguration.has(s)&&r.bondConfiguration.delete(s),r.kwargs.has(s)&&r.kwargs.delete(s),--s):(r.atomPairs[s][0]=t>e?t-1:t,r.atomPairs[s][1]=n>e?n-1:n),++s}let a=Array.from(r.bondConfiguration.keys());a.forEach((t=>{if(r.bondConfiguration.has(t)&&t>n){const e=r.bondConfiguration.get(t);r.bondConfiguration.delete(t),r.bondConfiguration.set(t-1,e)}})),a=Array.from(r.kwargs.keys()),a.forEach((t=>{if(r.kwargs.has(t)&&t>n){const e=r.kwargs.get(t);r.kwargs.delete(t),r.kwargs.set(t-1,e)}}))}}function C(t,e,n,i){const r=new t(e.length-i);let o=0,s=0;for(;o<e.length;)o===n&&(o+=i),r[s]=e[o],++s,++o;return r}function A(t,e){let n;if(0===t)n=e>0?0:Math.PI;else if(0===e)n=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,r=Math.atan(i);n=t<0?Math.PI/2+r:-Math.PI/2+r}return n}function S(t,e){if(0!==e){const n=t.x,i=t.y,r=Math.cos(e),o=Math.sin(e);for(let t=0;t<n.length;++t){const e=n[t];n[t]=(0,l.YN)(e*r-i[t]*o),i[t]=(0,l.YN)(e*o+i[t]*r)}}}function x(t){E(t,!1)}function E(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const n=t.bonds.bondConfiguration;for(const[t,e]of n){const i=1===e?3:1;n.set(t,i)}}function M(t,e,n){const i=t.atoms.x,r=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=(0,l.YN)(i[t]+e),void 0!==n&&(r[t]=(0,l.YN)(r[t]+n))}},294:(t,e,n)=>{"use strict";function i(t,e){return t[e.polymerType]?.[e.symbol]}function r(t,e){return!!t[e.polymerType]?.[e.symbol]}function o(t,e,n){let i=t[e.polymerType];i||(i=t[e.polymerType]={}),i[e.symbol]=n}n.d(e,{Cg:()=>s,LQ:()=>o,bq:()=>r,vF:()=>a,xb:()=>i});class s extends Map{constructor(t){super(t)}}class a{constructor(t,e){this.molfile=t,this.monomers=e}static createEmpty(){return new a("",new s(null))}}},330:(t,e,n)=>{"use strict";n.d(e,{kA:()=>r,pz:()=>s,qj:()=>o,vG:()=>a});var i=n(2003);function r(t,e){return t?t.columns.getUnusedName(e):e}function o(t,e){return r(t,`molfile(${e})`)}function s(t){let e;if(t===i.YI.PT||t===i.YI.UN)e="PEPTIDE";else{if(t!==i.YI.RNA&&t!==i.YI.DNA)throw new Error(`Unexpected alphabet '${t}'.`);e="RNA"}return e}function a(t){const e=7===t.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t);return e?[parseInt(e[1],16)/256,parseInt(e[2],16)/256,parseInt(e[3],16)/256,e.length>4?parseInt(e[4],16)/256:.3]:null}},1093:(t,e,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(t,e,n)=>{"use strict";n.d(e,{e:()=>i});class i{static makePalette(t,e=!1,n=i){const r={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{r[t]=this.colourPalette[i][e?0:n]}))})),new n(r)}constructor(t){this._palette=t}get(t,e){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(t,e,n)=>{"use strict";n.d(e,{O:()=>o,n:()=>r});var i=n(1858);class r{constructor(t,e=!0,n){return this.substructure=t,this.readOnly=e,this.logger=n,new Proxy(this,{set:(t,e,n)=>{if(this.logger?.debug(`BioFilterProps.set ${e.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return t[e]=n,!0}})}}class o{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(t){this._propsChanging=!0;try{this._props=t,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const t={};for(const[e,n]of Object.entries(this.props))"_onChanged"!==e&&"logger"!==e&&(t[e]=this.props[e]);return t}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(t,e,n)=>{"use strict";var i=n(6082),r=n(7362),o=n(6718);function s(t,e=!0){if(null==t)return"rgb(100,100,100)";const n=i.Color.fromHtml(t);if(e){const t=i.Color.g(n),e=i.Color.r(n),r=i.Color.b(n),o=Math.sqrt(Math.pow(0-e,2)+Math.pow(0-t,2)+Math.pow(0-r,2));if(o>210)return`rgb(${e/o*210},${t/o*210},${r/o*210})`}return i.Color.toRgb(n)}class a{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,o.pj)().then((t=>{t.awaitLoaded(1/0).then((()=>{const e=t.getMonomerLib();e.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=e.getPolymerTypes();for(const t of this.polymerTypes){const n=e.getMonomerSymbolsByType(t);for(const i of n){const n=e.getMonomer(t,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][t]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(r.e.colourPalette))}get(t,e){const n=c.palette.length,i=c.customMonomerColors[t],r=e??"PEPTIDE";if(i&&i[r])return i[r];const o=a.hashCode(t)%n;return s(c.palette[o])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(t,e,n)=>{"use strict";n.d(e,{BG:()=>s,sD:()=>l});var i=n(4328),r=n(1858),o=n(8070);function s(t){let e=null,n=null;try{n=t.dart?t.gridColumn:null,e=n?n.temp:null}catch{[n,e]=[null,null]}const i=t.cell.column;if(e=e??(i?i.temp:null),!e)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,e]}class a{onKeyDown(t,e){}onKeyPress(t,e){}onMouseEnter(t,e){}onMouseLeave(t,e){}onMouseDown(t,e){}onMouseUp(t,e){}onMouseMove(t,e){}onClick(t,e){}onDoubleClick(t,e){}}class l extends a{constructor(t,e,n){super(),this.gridCol=t,this.tableCol=e,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((t=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(t){this.logger.error(t)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((t=>{try{const e=t.args.dataFrame;this.tableCol?.dataFrame.id!==e.id||this.destroyed||this.destroy()}catch(t){this.logger.error(t)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((t=>{try{const e=t.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===e.id&&!this.destroyed&&this.destroy()}catch(t){this.logger.error(t)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const t of this.subs)t.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(t){this.invalidateGrid()}async awaitRendered(t=1e4,e=`${t} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,o.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),t,`${n}, ${e}`),this.errors.length>0){const t=this.errors[0];throw this.errors=[],t}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(t,e,n)=>{"use strict";n.d(e,{s:()=>i});const i={true:"1",false:"0"}},6882:(t,e,n)=>{"use strict";n.d(e,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(t,e,n,i,o){super(t,e,n),this.monomerLengthLimit=i,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol&&(this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{const t=this.tableCol.dataFrame;this.gridCol.grid,-1===t.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}))),this.subs.push(r.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&t.args.key===l.gp.positionShift))),200).subscribe((t=>{this.reset()}))))}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const t=await(0,h.pj)();this.sysMonomerLib=t.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(t){let e=12;return t&&t.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(e=Math.max(t.temp[".mm.cellRenderer.fontSize"],1)),{font:`${e}px monospace`,fontWidth:.6*e}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<e&&(this.colWidth=e,this.dirty=!0),this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(t){const e=new Array(t.length+1);e[0]=this.padding;for(let n=1;n<e.length;n++)e[n]=e[n-1]+t[n-1];let n=e[0];for(let t=1;t<e.length;t++)e[t]?n=e[t]:e[t]=n;return e}getCellMonomerLengthsForSeq(t){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const e=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=Math.ceil(this.colWidth/i)+e,o=n.getSplitted(t),s=Math.min(r,o.length);let a=this._monomerLengthList[t];if(null===a||a.length!=s-e){a=this._monomerLengthList[t]=new Array(o.length);let i=0;for(let t=e;t<s;++t){const r=o.getOriginal(t),s=this.props.monomerToShort(r,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[t-e]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqValue(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,o=Math.ceil(e/i)+r,s=n.splitter(t),a=Math.min(o,s.length),l=new Array(a-r);let c=0;for(let t=r;t<a;++t){const i=s.getOriginal(t),o=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+o.length*this.props.fontCharWidth;if(l[t-r]=a,c+=a,c>e)break}return l}getCellMonomerLengthsForSeqMsa(){var t;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const t=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return t&&t.dart?{startIdx:Math.max(Math.floor((t?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((t?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(t){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,s=Math.ceil(this.colWidth/r)+o;for(let t=n;t<i;t++){if(this._processedRows.get(t)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t,s),i=Math.min(s,n.length);i-o>e.length&&e.push(...new Array(i-o-e.length).fill(r));let a=0;for(let t=o;t<i;++t){const i=n.getOriginal(t),r=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+r.length*this.props.fontCharWidth;if(e[t-o]=Math.max(e[t-o]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(t,!0)}return e}getPosition(t,e,n,i){const[r,o]=this.getCellMonomerLengths(t,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t).length?null:function(t,e,n){if((n??0)>0&&e<(t[0]??0)+n)return-1;e-=n??0;let i,r=100,o=0,s=t.length-1;for(;o<=s;){if(i=Math.floor((s+o)/2),t[i]<=e&&e<t[i+1])return i;if(e<t[i]?s=i-1:o=i+1,--r<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(t)}. `)}return null}(o,e,i)}setMonomerLengthLimit(t){this.monomerLengthLimit!=t&&(this.monomerLengthLimit=t,this.dirty=!0)}setSeparatorWidth(t){this.separatorWidth!=t&&(this.props.separatorWidth=t,this.dirty=!0)}get positionShift(){const t=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(t)?0:Math.max(t,0)}render(t,e,n,i,r,o,a){const c=o.grid?.canvas===t.canvas;if(!this.seqHelper)return;const h=this.gridCol,m=this.tableCol,f=window.devicePixelRatio,g=this.positionShift,b=`${this.toLog()}.render()`;this.logger.debug(`${b}, start`);let w=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const t=parseInt(m.getTag(d.gp.maxMonomerLength));w=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const t=m.temp[".mm.cellRenderer.maxMonomerLength"];w=!isNaN(t)&&t?t:50}t.save();try{const a=this.seqHelper.getSeqHandler(m);if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=w){let t=0;const e=8;t=m.temp[".mm.cellRenderer.gapLength"]??t,this.setMonomerLengthLimit(w),this.setSeparatorWidth(a.isMsa()?e:t),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false}let[u,b]=this.getCellMonomerLengths(o.tableRowIndex,i);u.length;const C=o.cell.value,A=o.cell.rowIndex,S=(m.getTag(l.gp.alphabet),50);c&&(i=v(h?.grid,t,e,i,f)),t.beginPath(),t.rect(e+this.padding,n+this.padding,i-this.padding-1,r-2*this.padding),t.clip(),t.font=this.props?.font??"12px monospace",t.textBaseline="top";const x=m.meta.units,E=m.getTag(l.gp.aligned),M=m.getTag(l.gp.separator)??"",_=this.props.separatorWidth+1*this.props.fontCharWidth,I=Math.ceil(i/_)+g,T=m.temp["reference-sequence"],L=this.tableCol.temp["current-word"];L&&-1===m?.dataFrame?.currentRowIdx&&(this.tableCol.temp["current-word"]=null);const N=(()=>{const t=a.getSplitter(I)(null!=T&&""!=T?T:L??"");return s().count(0).take(t.length).slice(g).map((e=>t.getOriginal(e))).toArray()})(),P=c?a.getSplitted(A):a.splitter(C);c||(b=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(C,i)));let $=d.yg.classic;E&&E.includes("MSA")&&x==l.Hi.SEPARATOR&&($=d.yg.MSA),this._leftThreeDotsPadding=g>0?t.measureText("...").width:0;const R=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200"),O=Math.min(P.length,I);for(let s=g;s<O;++s){const l=s<P.length?P.getOriginal(s):a.defaultGapOriginal,c=s<P.length?P.getCanonical(s):a.defaultGapOriginal;let h=y;const u=this.getMonomerLib();if(u){const t=a.defaultBiotype;h=u.getMonomerTextColor(t,c)}t.fillStyle=y;const p={color:h,pivot:0,left:!0,transparencyRate:1,separator:M,last:s===P.length-1,drawStyle:$,maxWord:b,wordIdx:s-g,gridCell:o,referenceSequence:N,maxLengthOfMonomer:w,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(R)||R<1?void 0:R-g};if((0,d.oZ)(t,l,e+this.padding+this._leftThreeDotsPadding,n,i,r,p),S>i)break}if(g>0){const s={color:y,pivot:0,left:!0,transparencyRate:1,separator:M,last:!1,drawStyle:$,maxWord:b,wordIdx:0,gridCell:o,maxLengthOfMonomer:w,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(t,"...",e+this.padding,n,i,r,s)}}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n),this.errors.push(t)}finally{t.restore()}}onMouseMove(t,e){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==t.tableRowIndex)return;const r=this.positionShift,o=t.bounds,s=e.offsetX-t.gridColumn.left+(t.gridColumn.left-o.x),a=r>0&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0,c=this.getPosition(t.tableRowIndex,s,o.width,a);this.logger.debug(`${n}, start, argsX: ${s}, left: ${c}`);const h=this.seqHelper.getSeqHandler(this.tableCol),u=h.getSplitted(t.tableRowIndex);if(null!==c&&c>=0&&c+r<u.length){const n=h.alphabet??l.YI.UN,o={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:u.getCanonical(c+r)},s=[];let a=this._monomerStructureMap[o.symbol];{const t=this.getMonomerLib();a=this._monomerStructureMap[o.symbol]=t?t.getTooltip(o.biotype,o.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),e.x+16,e.y+16),(0,f.WN)(t,o)}else-1===c?i.tooltip.show(i.divText(`${Math.min(r,u.length)} hidden monomers`),e.x+16,e.y+16):i.tooltip.hide(),(0,f.WN)(t,null)}}function v(t,e,n,i,r){return t?Math.max(Math.min(t.canvas.width/r-n,i)):Math.max(e.canvas.width/r-n,0)}},3856:(t,e,n)=>{"use strict";n.d(e,{Mn:()=>l,gp:()=>a,oZ:()=>u,yg:()=>c});var i=n(7278);const r="#808080",o="rgb(0,0,0)",s=i.zS;var a,l,c;!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(a||(a={})),function(t){t.applyToBackground=".m.cellRenderer.applyToBackground"}(l||(l={})),function(t){t.MSA="MSA",t.classic="classic"}(c||(c={}));const h=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=c.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0}};function u(t,e,n,i,a,l,u){var d,p,m;const f=Object.assign(Object.assign({},h),u);u.logger?.debug("Bio: printLeftOrCentered(), start"),t.textAlign="start";let g=e.substring(0),y=f.last?"":f.separator;f.drawStyle===c.MSA&&(y="");let b=!0,v=!0,w="difference";if(null!=f.gridCell&&null!=f.gridCell.cell.column&&(b=f.gridCell.cell.column.temp["color-code"]??!0,v=f.gridCell.cell.column.temp["compare-with-current"]??!0,w=f.gridCell.cell.column.temp["highlight-difference"]??"difference"),f.referenceSequence){const t=f.referenceSequence[f.wordIdx];v&&f.referenceSequence.length>0&&"difference"===w&&(f.transparencyRate=g==t?.3:f.transparencyRate),v&&f.referenceSequence.length>0&&"equal"===w&&(f.transparencyRate=g!=t?.3:f.transparencyRate)}null!=f.maxLengthOfMonomer&&(g=s(g,f.maxLengthOfMonomer));const C=g+y;(d=f.monomerTextSizeMap)[C]??(d[C]=t.measureText(C));let A=f.monomerTextSizeMap[C];(p=f.monomerTextSizeMap)[g]??(p[g]=t.measureText(g));let S=f.monomerTextSizeMap[g].width;const x=l/2-(A.fontBoundingBoxAscent+A.fontBoundingBoxDescent)/2+1;(m=f.monomerTextSizeMap)[y]??(m[y]=t.measureText(y));const E=f.monomerTextSizeMap[y].width;function M(e,s){f.selectedPosition===f.wordIdx+1&&(t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n+e,i,S,l));const a=b?f.color:o;t.fillStyle=a,t.globalAlpha=f.transparencyRate,f.drawStyle===c.classic&&(t.fillText(g,n+e,i+x),t.fillStyle=r,t.fillText(y,n+s,i+x)),f.drawStyle===c.MSA&&t.fillText(g,n+e,i+x)}A=A.width,f.drawStyle===c.MSA&&(S=f.maxWord[f.wordIdx],A=f.maxWord[f.wordIdx]);const _=(f.maxWord[f.wordIdx]??0)-(f.maxWord[0]??0);if(f.left||A>a)return M(_,_+S),n+_+S+E;{const t=(a-A)/2;return M(t,t+S),n+_+t+S}}},3151:(t,e,n)=>{"use strict";n.d(e,{EK:()=>l,Ec:()=>o,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>r});const i=["symbol","molfile","rgroups","name"],r="MonomerName",o={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(t,e,n)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function r(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?r(t.$thrownJsError):void 0}function o(t){return[i(t),r(t)]}n.d(e,{AP:()=>o})},3516:(t,e,n)=>{"use strict";n.d(e,{m:()=>o});var i=n(6082),r=n(439);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.meta.units=r.Hi.FASTA,[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6873:(t,e,n)=>{"use strict";n.d(e,{Hx:()=>h,dW:()=>c});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(7278),l=n(439);function c(t=10**5){const e="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(t/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function h(t,e=s.Hi.SEPARATOR,n=s.YI.PT,r=(e===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=e,f.setTag(s.gp.alphabet,n),e==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,r);const g=t.getSeqHandler(f);for(let t=0;t<u;t++){const n=o().count(0).take(d).map((t=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[e]));f.set(t,i)}return f}},439:(t,e,n)=>{"use strict";n.d(e,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>r,_S:()=>u,b9:()=>d,gp:()=>o,q7:()=>h,z1:()=>a});var i,r,o,s=n(2738);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm",t.CUSTOM="custom"}(i||(i={})),function(t){t.DNA="DNA",t.RNA="RNA",t.PT="PT",t.UN="UN"}(r||(r={})),function(t){t.aligned="aligned",t.alphabet="alphabet",t.alphabetSize=".alphabetSize",t.alphabetIsMultichar=".alphabetIsMultichar",t.separator="separator",t.isHelmCompatible=".isHelmCompatible",t.positionNames=".positionNames",t.positionLabels=".positionLabels",t.regions=".regions",t.positionShift=".positionShift",t.selectedPosition=".selectedPosition"}(o||(o={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(r.PT,c.fasta.peptide,.5),new s.a(r.DNA,c.fasta.dna,.55),new s.a(r.RNA,c.fasta.rna,.55)],u="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"}},2003:(t,e,n)=>{"use strict";n.d(e,{Hi:()=>i.Hi,J9:()=>r.J9,Qf:()=>r.Qf,YI:()=>i.YI,dh:()=>r.dh,gp:()=>i.gp,mn:()=>r.mn,q7:()=>i.q7,qp:()=>r.qp,z1:()=>i.z1,zS:()=>r.zS});var i=n(439),r=n(7278)},2738:(t,e,n)=>{"use strict";n.d(e,{X:()=>r,a:()=>i});class i{constructor(t,e,n){this.name=t,this.alphabet=e,this.cutoff=n}}class r extends i{constructor(t,e,n){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=n}}},7278:(t,e,n)=>{"use strict";n.d(e,{Iv:()=>y,J9:()=>p,Mu:()=>u,Qf:()=>w,dh:()=>f,mn:()=>S,p0:()=>A,pc:()=>C,qp:()=>g,tm:()=>m,zS:()=>v});var i=n(6082),r=n(1991),o=n.n(r),s=n(3527),a=n(3629),l=n(2738),c=n(439),h=(n(8924),n(1093),n(4152),n(8438));class u{get length(){return this.mList.length}isGap(t){return this.getOriginal(t)===this.gapOriginalMonomer}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");const e=this.mList[t];return e!==this.gapOriginalMonomer?e:c._S}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.mList[t]}constructor(t,e){this.mList=t,this.gapOriginalMonomer=e}}class d{get length(){return this.seqS.length}isGap(t){return this.getOriginal(t)===c.b9[c.Hi.FASTA]}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");return this.isGap(t)?c._S:this.seqS[t]}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.seqS[t]}constructor(t){this.seqS=t}}const p=t=>{const e=o()(t.toString().matchAll(c.B5)).map((t=>t[2]??t[1])).toArray();return new u(e,c.b9[c.Hi.FASTA])},m=t=>t?new d(t):new u([],c.b9[c.Hi.FASTA]);function f(t,e=void 0){return n=>{if(n){let i;const r=new RegExp(`(?<=^|\\${t})("-"|'-'|[^\\${t}]*)(?=\\${t}|$)`,"g");return void 0!==e?(r.lastIndex=0,i=o()(n.matchAll(r)).take(e).map((t=>t[0])).toArray()):i=n.replaceAll('"-"',"").replaceAll("'-'","").split(t,e),new u(i,c.b9[c.Hi.SEPARATOR])}return new u([],c.b9[c.Hi.SEPARATOR])}}const g=t=>{const e=t.split("$")[0].split("|"),n=o()(e.map((t=>(t.match(/(?<=\{).+(?=})/)?.[0]?.split(".")??[]).map((t=>(0,h.D)(t)))))).flatten().toArray();return new u(n,c.b9[c.Hi.HELM])};function y(t,e,n=void 0){if(t.toLowerCase().startsWith(c.Hi.FASTA))return p;if(t.toLowerCase().startsWith(c.Hi.SEPARATOR))return f(e,n);if(t.toLowerCase().startsWith(c.Hi.HELM))return g;throw new Error(`Unexpected units ${t} .`)}const b=/([^\W_]+)/g;function v(t,e){if(t.length<=e)return t;const n=t.match(b),i=t.length>e||(n?.length??0)>1,r=n?.[0]??" ";return i?r.substring(0,e-1)+"…":r}function w(t){switch(t){case c.YI.DNA:return c.Vl.fasta.dna;case c.YI.RNA:return c.Vl.fasta.rna;case c.YI.PT:return c.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${t}'.`)}}function C(t,e,n="-"){const i=e.map((e=>{const i=function(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const r=[],o=[];for(const n of i)r.push(n in t?t[n]:0),o.push(e.has(n)?1:0);const l=new s.Mi(r),c=new s.Mi(o);return(0,a.KE)(l,c)/((0,a.wQ)(l)*(0,a.wQ)(c))}(t,e.alphabet,n);return new l.X(e,t,i)}));let r;const o=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return r=o>0?i.find((t=>t.similarity===o)).name:c.YI.UN,r}function A(t,e,n="-"){const i=Object.keys(t),r=/\(|\)/;return C(i.filter((t=>3===t.split(r).filter((t=>!!t)).length)).length>.8*i.length?Object.entries(t).reduce(((t,[e,n])=>{const i=e.split(r)[1];return i&&(t[i]=n),t}),{}):t,e,n)}function S(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=e.find((t=>{const e=t.meta.units;return!!e&&-1!==e.indexOf("MSA")}))??null;return!n&&e.length>0&&(n=e[0]),n}},8312:(t,e,n)=>{"use strict";n.d(e,{Q:()=>r});var i=n(6082);async function r(){const t=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===t.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await t[0].prepare().call()).getOutputParamValue()}},3077:(t,e,n)=>{"use strict";n.d(e,{R:()=>r});var i=n(6082);function r(t,e){const n=t=>{const e=s.columns.addNewString((t+1).toString());return r.push(e),e},r=[],o=t.length,s=i.DataFrame.create(o),a=e.getSeqHandler(t);for(let t=0;t<o;++t){const e=a.getSplitted(t);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);((r[i]??null)||n(i)).set(t,o,!1)}}return s}},7602:(t,e,n)=>{"use strict";n.d(e,{g:()=>o});var i,r=n(9192);!function(t){t[t.error=0]="error",t[t.warning=1]="warning",t[t.info=2]="info",t[t.debug=3]="debug"}(i||(i={}));class o{constructor(t){this.logger=t,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(t,e){const n=++this.syncCounter;this.logger.debug(`${t}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${t}, SYNC syncId = ${n}, START `),await e(),this.logger.debug(`${t}, SYNC syncId = ${n}, END `)})).catch((e=>{const[i,o]=(0,r.AP)(e);this.logger.error(`${t}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,o),this.errors.push(e)}))}resetErrors(){const t=this.errors;return this.errors=[],t}}},4326:(t,e,n)=>{"use strict";n.d(e,{Fo:()=>h,Lp:()=>o,P4:()=>s,fH:()=>r,gp:()=>i,lT:()=>l,mH:()=>a});var i,r,o,s,a,l,c=n(6082);!function(t){t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(r||(r={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(o||(o={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(s||(s={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=20,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=25,this.maxHeight=300,this.maxMonomerLetters=5,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},6869:(t,e,n)=>{"use strict";var i;n.d(e,{o:()=>i}),function(t){t.BASE="HELM_BASE",t.SUGAR="HELM_SUGAR",t.LINKER="HELM_LINKER",t.AA="HELM_AA",t.CHEM="HELM_CHEM",t.BLOB="HELM_BLOB",t.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},5540:(t,e,n)=>{"use strict";t=n.hmd(t);var i,r=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(t={}){var e,n,r=void 0!==t?t:{};r.ready=new Promise((function(t,i){e=t,n=i}));var o,s=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(o=t=>{var e=new XMLHttpRequest;return e.open("GET",t,!1),e.responseType="arraybuffer",e.send(null),new Uint8Array(e.response)})),r.print||console.log.bind(console);var h,u,d=r.printErr||console.warn.bind(console);Object.assign(r,s),s=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(h=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&M("no native wasm support detected");var p,m,f,g=!1;function y(){var t=u.buffer;r.HEAP8=p=new Int8Array(t),r.HEAP16=new Int16Array(t),r.HEAP32=new Int32Array(t),r.HEAPU8=m=new Uint8Array(t),r.HEAPU16=new Uint16Array(t),r.HEAPU32=f=new Uint32Array(t),r.HEAPF32=new Float32Array(t),r.HEAPF64=new Float64Array(t)}var b,v,w=[],C=[],A=[],S=0,x=null,E=null;function M(t){r.onAbort&&r.onAbort(t),d(t="Aborted("+t+")"),g=!0,t+=". Build with -sASSERTIONS for more info.";var e=new WebAssembly.RuntimeError(t);throw n(e),e}function _(t){return t.startsWith("data:application/octet-stream;base64,")}function I(t){try{if(t==b&&h)return new Uint8Array(h);if(o)return o(t);throw"both async and sync fetching of the wasm failed"}catch(t){M(t)}}function T(t,e,n){return function(t){return h||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return I(t)})):fetch(t,{credentials:"same-origin"}).then((function(e){if(!e.ok)throw"failed to load wasm binary file at '"+t+"'";return e.arrayBuffer()})).catch((function(){return I(t)}))}(t).then((function(t){return WebAssembly.instantiate(t,e)})).then((function(t){return t})).then(n,(function(t){d("failed to asynchronously prepare wasm: "+t),M(t)}))}function L(t){for(;t.length>0;)t.shift()(r)}function N(t){this.excPtr=t,this.ptr=t-24,this.set_type=function(t){f[this.ptr+4>>2]=t},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(t){f[this.ptr+8>>2]=t},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(t){t=t?1:0,p[this.ptr+12|0]=t},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(t){t=t?1:0,p[this.ptr+13|0]=t},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(t,e){this.set_adjusted_ptr(0),this.set_type(t),this.set_destructor(e)},this.set_adjusted_ptr=function(t){f[this.ptr+16>>2]=t},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(D(this.get_type()))return f[this.excPtr>>2];var t=this.get_adjusted_ptr();return 0!==t?t:this.excPtr}}function P(t){var e=u.buffer;try{return u.grow(t-e.byteLength+65535>>>16),y(),1}catch(t){}}function $(t){return r["_"+t]}_(b="wasmDbscan.wasm")||(v=b,b=r.locateFile?r.locateFile(v,c):c+v);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(t,e,n,i,r){var o={string:t=>{var e=0;return null!=t&&0!==t&&(e=function(t){var e=function(t){for(var e=0,n=0;n<t.length;++n){var i=t.charCodeAt(n);i<=127?e++:i<=2047?e+=2:i>=55296&&i<=57343?(e+=4,++n):e+=3}return e}(t)+1,n=B(e);return function(t,e,n){!function(t,e,n,i){if(!(i>0))return 0;for(var r=n+i-1,o=0;o<t.length;++o){var s=t.charCodeAt(o);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&t.charCodeAt(++o)),s<=127){if(n>=r)break;e[n++]=s}else if(s<=2047){if(n+1>=r)break;e[n++]=192|s>>6,e[n++]=128|63&s}else if(s<=65535){if(n+2>=r)break;e[n++]=224|s>>12,e[n++]=128|s>>6&63,e[n++]=128|63&s}else{if(n+3>=r)break;e[n++]=240|s>>18,e[n++]=128|s>>12&63,e[n++]=128|s>>6&63,e[n++]=128|63&s}}e[n]=0}(t,m,e,n)}(t,n,e),n}(t)),e},array:t=>{var e,n,i=B(t.length);return e=t,n=i,p.set(e,n),i}},s=$(t),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var h=o[n[c]];h?(0===l&&(l=F()),a[c]=h(i[c])):a[c]=i[c]}var u=s.apply(null,a);return function(t){return 0!==l&&H(l),function(t){return"string"===e?(n=t)?function(t,e,n){for(var i=e+n,r=e;t[r]&&!(r>=i);)++r;if(r-e>16&&t.buffer&&R)return R.decode(t.subarray(e,r));for(var o="";e<r;){var s=t[e++];if(128&s){var a=63&t[e++];if(192!=(224&s)){var l=63&t[e++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&t[e++])<65536)o+=String.fromCharCode(s);else{var c=s-65536;o+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else o+=String.fromCharCode((31&s)<<6|a)}else o+=String.fromCharCode(s)}return o}(m,n,i):"":"boolean"===e?Boolean(t):t;var n,i}(t)}(u)}var k,G={__cxa_throw:function(t,e,n){throw new N(t).init(e,n),t},abort:function(){M("")},emscripten_memcpy_big:function(t,e,n){m.copyWithin(t,e,e+n)},emscripten_resize_heap:function(t){var e,n=m.length,i=2147483648;if((t>>>=0)>i)return!1;for(var r=1;r<=4;r*=2){var o=n*(1+.2/r);if(o=Math.min(o,t+100663296),P(Math.min(i,(e=Math.max(t,o))+(65536-e%65536)%65536)))return!0}return!1}},F=(function(){var t,e,i,o,s={env:G,wasi_snapshot_preview1:G};function a(t,e){var n,i=t.exports;return r.asm=i,u=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,C.unshift(n),function(){if(S--,r.monitorRunDependencies&&r.monitorRunDependencies(S),0==S&&(null!==x&&(clearInterval(x),x=null),E)){var t=E;E=null,t()}}(),i}if(S++,r.monitorRunDependencies&&r.monitorRunDependencies(S),r.instantiateWasm)try{return r.instantiateWasm(s,a)}catch(t){d("Module.instantiateWasm callback failed with error: "+t),n(t)}(t=h,e=b,i=s,o=function(t){a(t.instance)},t||"function"!=typeof WebAssembly.instantiateStreaming||_(e)||"function"!=typeof fetch?T(e,i,o):fetch(e,{credentials:"same-origin"}).then((function(t){return WebAssembly.instantiateStreaming(t,i).then(o,(function(t){return d("wasm streaming compile failed: "+t),d("falling back to ArrayBuffer instantiation"),T(e,i,o)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(F=r.asm.stackSave).apply(null,arguments)}),H=function(){return(H=r.asm.stackRestore).apply(null,arguments)},B=function(){return(B=r.asm.stackAlloc).apply(null,arguments)},D=function(){return(D=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function t(){k||(k=!0,r.calledRun=!0,g||(L(C),e(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)t=r.postRun.shift(),A.unshift(t);var t;L(A)}()))}S>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)t=r.preRun.shift(),w.unshift(t);var t;L(w)}(),S>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),t()}),1)):t()))}if(r.ccall=O,r.cwrap=function(t,e,n,i){var r=!n||n.every((t=>"number"===t||"boolean"===t));return"string"!==e&&r&&!i?$(t):function(){return O(t,e,n,arguments)}},E=function t(){k||V(),k||(E=t)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return V(),t.ready});"object"==typeof exports?t.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6295:(t,e,n)=>{"use strict";n.d(e,{$1:()=>a,Hf:()=>u,Hr:()=>M,Ii:()=>y,Qj:()=>f,T6:()=>E,TK:()=>S,be:()=>g,gt:()=>w,iS:()=>s,ij:()=>C,jL:()=>h,lO:()=>m,lP:()=>v,rR:()=>b,tO:()=>l,v_:()=>c,w_:()=>d,yK:()=>A,zn:()=>p});var i=n(8774),r=n(8498),o=n(6863);r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean,r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean;const s=[r.aT.Tanimoto,r.aT.Dice,r.aT.Cosine];function a(t,e){const n=t.trueCount()+e.trueCount();if(0==n)return 1;const i=t.andWithCountBits(e,!0);return i/(n-i)}function l(t,e){return 1-a(t,e)}function c(t,e){return x(a(new i.A(t,32*t.length),new i.A(e,32*e.length)))}function h(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.pow(t[i]-e[i],2);return Math.sqrt(n)}function u(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.abs(t[i]-e[i]);return n}function d(t,e){let n=0,i=0,r=0;for(let o=0;o<t.length;o++)n+=t[o]*e[o],i+=t[o]*t[o],r+=e[o]*e[o];return(1-n/(Math.sqrt(i)*Math.sqrt(r)))/2}function p(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount();return 0==n?0:2*t.andWithCountBits(e,!0)/n}(t,e)}function m(t,e){return 1-function(t,e){const n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)/Math.sqrt(n)}(t,e)}function f(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}function g(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)}function y(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*n-3*i)}(t,e)}function b(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*n/(2*i)}(t,e))}function v(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*n-i)/i}(t,e))}function w(t,e){return 1-function(t,e){const n=Math.min(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e)}function C(t,e){return x(function(t,e){const n=Math.max(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))}function A(t,e){return x(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))}function S(t,e){return x(function(t,e){const n=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),r=t.length,o=r-i+n;return n==r||o==r?1:n/i+o/(2*r-i)}(t,e))}function x(t){return t<=0?3402823e32:1/t-1}function E(t){if(t&&null!=t.range&&t.range>0){const e=t.range;return(t,n)=>Math.abs(t-n)/e}return(t,e)=>Math.abs(t-e)}function M(t){const e=function(t){const e=t?.mostCommon??new Set;return(t,n)=>{const i=t.length,r=n.length;let o=0,s=0,a=0;for(;s<i&&a<r;)t[s]===n[a]?(e?.has(t[s])||++o,++s,++a):t[s]<n[a]?++s:++a;return o}}(t);return(t,n)=>0===n.length||0===t.length?1e4:Math.min(t.length,n.length)/(e(t,n)+1e-4)}r.aT.Tanimoto,r.aT.Asymmetric,r.aT.Cosine,r.aT.Sokal,o.Z.HAMMING,o.Z.LEVENSHTEIN,o.Z.MONOMER_CHEMICAL_DISTANCE,o.Z.NEEDLEMANN_WUNSCH},684:(t,e,n)=>{"use strict";n.d(e,{C0:()=>o,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>r,vb:()=>l});const i="dim-red-preprocessing-function",r="supportedSemTypes",o="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(t,e,n)=>{"use strict";function i(t={}){const e=function(){if(!t||!t.scoringMatrix||!t.alphabetIndexes)return(t,e)=>t===e?0:1;if(t.scoringMatrix.length!==Object.keys(t.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const e=t.alphabetIndexes,n=t.scoringMatrix,i=Math.min(...Object.keys(e).map((t=>t.charCodeAt(0))))+1,r=new Float32Array((n.length+i)*(n.length+i));return Object.entries(e).forEach((([t,i])=>{const o=n[i];Object.entries(e).forEach((([e,i])=>{r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]=o[i]}))})),(t,e)=>1-r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]}(),n=t?.threshold??0;return(t,i)=>{let r=0;const o=t.length,s=i.length,a=Math.ceil(Math.max(o,s)*(1-n));o!==s&&(r=Math.abs(o-s));let l=0;for(let n=0;n<Math.min(o,s);n++)if(t[n]!==i[n]&&(l+=e(t[n],i[n]),l>a))return 1;return l+=r,l/=Math.max(o,s),l}}n.d(e,{Z:()=>s,V:()=>a});var r=n(2787);const o={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(t){t.HAMMING="Hamming",t.LEVENSHTEIN="Levenshtein",t.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",t.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(t,e)=>(0,r.I)(t,e)/Math.max(t.length,e.length)},[s.NEEDLEMANN_WUNSCH]:function(t){const e=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:r,alphabetIndexes:s}={...o,...t};Object.entries(s).forEach((([t,n])=>e[t.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(t,o)=>{const s=new Array(t.length+1).fill(!1),l=new Array(t.length+1).fill(!1);let c=0,h=1;for(let e=1;e<t.length+1;e++)a[0][e]=-i-(e-1)*i,a[1][e]=0;a[0][0]=0;for(let u=1;u<o.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<t.length+1;d++){const p=a[c][d-1]+r[e[t.charCodeAt(d-1)]][e[o.charCodeAt(u-1)]],m=a[c][d]-(s[d]||1===u||u===o.length?i:n),f=a[h][d-1]-(l[d-1]||1===d||d===t.length?i:n);a[h][d]=Math.max(p,f,m),a[h][d]===p?(s[d]=!1,l[d]=!1):a[h][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=h,h=(h+1)%2}const u=Math.min(t.length,o.length);return(u-a[c][t.length])/u}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},8060:(t,e,n)=>{"use strict";n.d(e,{S:()=>i});const i="dimensionality-reducer-terminate-event"},9039:(t,e,n)=>{"use strict";var i;n.d(e,{c:()=>i}),function(t){t.UMAP="UMAP",t.T_SNE="t-SNE"}(i||(i={}))},8498:(t,e,n)=>{"use strict";var i,r,o,s,a,l,c;n.d(e,{EG:()=>a,Pn:()=>r,RR:()=>l,Wn:()=>c,aT:()=>o,m6:()=>s,xL:()=>i}),function(t){t.Levenshtein="Levenshtein",t.JaroWinkler="Jaro-Winkler",t.Manhattan="Manhattan String",t.Onehot="One-Hot"}(i||(i={})),function(t){t.Euclidean="Euclidean",t.Manhattan="Manhattan",t.Cosine="Vector Cosine"}(r||(r={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean BitArray"}(o||(o={})),function(t){t.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(t){t.Vector="Vector",t.String="String",t.BitArray="BitArray",t.MacroMolecule="MacroMolecule",t.Number="Number",t.IntArray="IntArray",t.NumberArray="NumberArray"}(a||(a={})),function(t){t.Difference="Difference"}(l||(l={})),function(t){t.CommonItems="Common Items"}(c||(c={}))},2780:(t,e,n)=>{"use strict";n(8498),n(9336)},9336:(t,e,n)=>{"use strict";var i=n(2787),r=n(944),o=n(6295),s=n(6863),a=n(8498);const l={[a.Pn.Euclidean]:o.jL,[a.Pn.Manhattan]:o.Hf,[a.Pn.Cosine]:o.w_},c={[a.xL.Levenshtein]:i.I,[a.xL.JaroWinkler]:r.Vb,[a.xL.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let n=0;for(let i=1;i<t.length;i++)n+=t[i]==e[i]?0:1;return n/t.length}},[a.xL.Onehot]:function(t,e){return t===e?0:1}},h={[a.aT.Tanimoto]:o.tO,[a.aT.Dice]:o.zn,[a.aT.Asymmetric]:o.gt,[a.aT.BraunBlanquet]:o.ij,[a.aT.Cosine]:o.lO,[a.aT.Kulczynski]:o.rR,[a.aT.McConnaughey]:o.lP,[a.aT.RogotGoldberg]:o.TK,[a.aT.Russel]:o.yK,[a.aT.Sokal]:o.Ii,[a.aT.Hamming]:o.be,[a.aT.Euclidean]:o.Qj},u={[a.m6.TanimotoIntArray]:o.v_},d={[a.RR.Difference]:o.T6},p={[a.Wn.CommonItems]:o.Hr},m={[a.EG.Vector]:{[a.Pn.Euclidean]:l[a.Pn.Euclidean],[a.Pn.Manhattan]:l[a.Pn.Manhattan],[a.Pn.Cosine]:l[a.Pn.Cosine]},[a.EG.String]:{[a.xL.Levenshtein]:c[a.xL.Levenshtein],[a.xL.JaroWinkler]:c[a.xL.JaroWinkler],[a.xL.Manhattan]:c[a.xL.Manhattan],[a.xL.Onehot]:c[a.xL.Onehot]},[a.EG.BitArray]:{[a.aT.Tanimoto]:h[a.aT.Tanimoto],[a.aT.Dice]:h[a.aT.Dice],[a.aT.Asymmetric]:h[a.aT.Asymmetric],[a.aT.BraunBlanquet]:h[a.aT.BraunBlanquet],[a.aT.Cosine]:h[a.aT.Cosine],[a.aT.Kulczynski]:h[a.aT.Kulczynski],[a.aT.McConnaughey]:h[a.aT.McConnaughey],[a.aT.RogotGoldberg]:h[a.aT.RogotGoldberg],[a.aT.Russel]:h[a.aT.Russel],[a.aT.Sokal]:h[a.aT.Sokal]},[a.EG.MacroMolecule]:{[s.Z.HAMMING]:s.V[s.Z.HAMMING],[s.Z.LEVENSHTEIN]:s.V[s.Z.LEVENSHTEIN],[s.Z.NEEDLEMANN_WUNSCH]:s.V[s.Z.NEEDLEMANN_WUNSCH],[s.Z.MONOMER_CHEMICAL_DISTANCE]:s.V[s.Z.MONOMER_CHEMICAL_DISTANCE]},[a.EG.Number]:{[a.RR.Difference]:d[a.RR.Difference]},[a.EG.IntArray]:{[a.m6.TanimotoIntArray]:u[a.m6.TanimotoIntArray]},[a.EG.NumberArray]:{[a.Wn.CommonItems]:p[a.Wn.CommonItems]}};Object.keys(m).reduce(((t,e)=>{for(const n of Object.keys(m[e]))t[n]=e;return t}),{})},8774:(t,e,n)=>{"use strict";n.d(e,{A:()=>i});class i{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const n=t,r=i._createBuffer(n);if(e)for(let t=0;t<r.length;t++)r[t]=-1;this._data=r,this._length=n}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,n,i){if(t<e||t>n)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${n})`)}copy(t,e,n){for(let i=0;i<n;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const n=new i(t._length);n._length=t._length,n._data=i._createBuffer(n._length),n._version=0;const r=t.lengthInInts;for(let i=0;i<r;i++)n._data[i]=t._data[i]&e._data[i];return n}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new i(t.length);e._version=0;for(let n=0;n<e._length;n++)t[n]&&(e._data[Math.floor(n/32)]|=1<<(n%32&31));return e}static fromSeq(t,e){const n=new i(t);for(let i=0;i<t;++i)n.setBit(i,e(i));return n._version=0,n}static fromString(t){return i.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const n=new i(t);return n._data=e,n}static fromBytes(t){const e=t.length,n=new i(8*e);n._data=new Uint32Array(Math.floor((e+3)/4)),n._length=8*e;let r=0,o=0;for(;e-o>=4;)n._data[r++]=255&t[o]|(255&t[o+1])<<8|(255&t[o+2])<<16|(255&t[o+3])<<24,o+=4;return e-o==3&&(n._data[r]=(255&t[o+2])<<16),e-o==2&&(n._data[r]|=(255&t[o+1])<<8),e-o==1&&(n._data[r]|=255&t[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new i(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,i=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,i=!0,r=!0){if(n&&r&&this.setAll(!e,!1),r)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return n}setRange(t,e,n,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const r=Math.min(t,e),o=Math.max(t,e);if(n)for(let t=r;t<=o;t++)this.setTrue(t);else for(let t=r;t<=o;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,n=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const i=this._length;this.setLength(this._length+e);for(let n=i-1;n>=t;n--)this.setBit(n+e,this.getBit(n));for(let i=t;i<t+e;i++)this.setBit(i,n)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let n=t;n<this._length-e;n++)this.setBit(n,this.getBit(n+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let n=0;for(let i=-1;-1!=(i=t.findNext(i,!e));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(t){return!!(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,n=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=i._onBitCount[255&t];let n=this._data[e];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)e+=t(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)e+=t(n)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let o=0;for(;o<r-1;o++)for(let e=this._data[o]&t._data[o];0!=e;e>>>=8)n+=i._onBitCount[255&e];let s=this._data[o]&t._data[o];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return e?n:this._length-n}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let n=31&(t=t<0?0:t+1);const r=this.lengthInInts;for(let o=Math.floor(t/32);o<r;o++){let r=e?this._data[o]:~this._data[o];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!e&&-4294967296==r)continue;for(let e=0;0!=r;e+=8,r>>>=8){const n=i._firstOnBit[255&r];if(n>=0)return(t=n+32*o+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let n=1+(t=t<0?this._length-1:t-1)&31;for(let r=Math.floor(t/32);r>=0;r--){let t=e?this._data[r]:~this._data[r];0!=n&&(t&=~(4294967295<<n),n=0);for(let e=24;0!=t;e-=8,t<<=8){const n=i._lastOnBit[t>>>24];if(n>=0)return n+32*r+e}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(t,e,n)=>{"use strict";n.d(e,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,o=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function s(t,e,n,i=0,r="timeout"){return o(this,void 0,void 0,(function*(){return new Promise(((o,s)=>{const a=t.subscribe((t=>{try{e(t),o("OK")}catch(t){s(t)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(r)}),i);n()}))}))}function a(t){return o(this,void 0,void 0,(function*(){yield new Promise((e=>setTimeout(e,t)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(r||(r={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3527:(t,e,n)=>{"use strict";n.d(e,{Mi:()=>i});class i extends Float32Array{}},3629:(t,e,n)=>{"use strict";n.d(e,{KE:()=>a,S8:()=>l,dC:()=>o,vA:()=>r,wQ:()=>s});var i=n(3527);function r(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function o(t,e,n=1){const o=t.length;r(o==e.length,"Vector lengths do not match.");const s=new i.Mi(o);for(let i=0;i<t.length;++i)s[i]=t[i]+n*e[i];return s}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function a(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}function l(t){const e=t.length;let n=0,i=0;for(let r=0;r<e;++r)n+=t[r],i+=Math.pow(t[r],2);const r=n/e,o=1/Math.sqrt(i/e-Math.pow(r,2));for(let n=0;n<e;++n)t[n]=(t[n]-r)*o;return t}},1913:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3282),r=n(9029),o=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",h=new i.Name("emUsed"),u={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(t,e={})=>{if(!t.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(t.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return t.addKeyword(function(t){return{keyword:c,schemaType:["string","object"],post:!0,code(e){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=e;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(t,e){return r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath === ${w}`,i._`${t}.keyword in ${e}`,i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${t}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(t,e){const i=[];for(const n in t){const t=e[n];d.test(t)&&i.push([n,x(t)])}return n.object(...i)}function S(t){return d.test(t)?new o._Code(o.safeStringify(t).replace(p,((t,e)=>`" + JSON.stringify(${s.getData(e,b)}) + "`)).replace(m,"")):i.stringify(t)}function x(t){return i._`function(){return ${S(t)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[o,s]=function(t){let e,n;for(const i in t){if("properties"===i||"items"===i)continue;const r=t[i];if("object"==typeof r){e||(e={});const t=e[i]={};for(const e in r)t[e]=[]}else n||(n={}),n[i]=[]}return[e,n]}(v);s&&function(r){const o=n.const("emErrors",i.stringify(r)),s=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(t=>n.if(C(t,o),(()=>n.code(i._`${o}[${t}.keyword].push(${t})`).assign(i._`${t}.${h}`,!0)))));const{singleError:c}=t;if(c){const t=n.let("message",i._`""`),r=n.let("paramsErrors",i._`[]`);u((e=>{n.if(t,(()=>n.code(i._`${t} += ${"string"==typeof c?c:";"}`))),n.code(i._`${t} += ${d(e)}`),n.assign(r,i._`${r}.concat(${o}[${e}])`)})),a.reportError(e,{message:t,params:i._`{errors: ${r}}`})}else u((t=>a.reportError(e,{message:d(t),params:i._`{errors: ${o}[${t}]}`})));function u(t){n.forIn("key",o,(e=>n.if(i._`${o}[${e}].length`,(()=>t(e)))))}function d(t){return i._`${t} in ${s} ? ${s}[${t}]() : ${y}[${t}]`}}(s),o&&function(t){const r=n.const("emErrors",i.stringify(t)),o=[];for(const e in t)o.push([e,A(t[e],g[e])]);const s=n.const("templates",n.object(...o)),c=n.scopeValue("obj",{ref:u,code:i.stringify(u)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(t=>n.if(C(t,r),(()=>{n.assign(d,i._`${c}[${t}.keyword]`),n.assign(p,i._`${r}[${t}.keyword][${t}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${t})`).assign(i._`${t}.${h}`,!0)))})))),n.forIn("key",r,(t=>n.forIn("keyProp",i._`${r}[${t}]`,(o=>{n.assign(p,i._`${r}[${t}][${o}]`),n.if(i._`${p}.length`,(()=>{const r=n.const("tmpl",i._`${s}[${t}] && ${s}[${t}][${o}]`);a.reportError(e,{message:i._`${r} ? ${r}() : ${y}[${t}][${o}]`,params:i._`{errors: ${p}}`})}))}))))}(o),function(t){const{props:o,items:s}=t;if(!o&&!s)return;const u=i._`typeof ${f} == "object"`,d=i._`Array.isArray(${f})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(t,e){n.assign(p,i.stringify(t)),n.assign(v,A(t,e))}o&&s?(m=n.let("emChildKwd"),n.if(u),n.if(d,(()=>{C(s,g.items),n.assign(m,i.str`items`)}),(()=>{C(o,g.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,g.items),b=i._`.items`):o&&(n.if(r.and(u,r.not(d))),C(o,g.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(t=>function(t,e,o){n.if(r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${r}.exec(${t}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${e}`,(()=>o(a)))}))}(t,p,(e=>n.code(i._`${p}[${e}].push(${t})`).assign(i._`${t}.${h}`,!0))))),n.forIn("key",p,(t=>n.if(i._`${p}[${t}].length`,(()=>{a.reportError(e,{message:i._`${t} in ${v} ? ${v}[${t}]() : ${y}${b}[${t}]`,params:i._`{errors: ${p}[${t}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:t,items:e}){const n={};if(t){n.props={};for(const e in t)n.props[e]=[]}if(e){n.items={};for(let t=0;t<e.length;t++)n.items[t]=[]}return n}(v))}const o="string"==typeof v?v:v._;o&&function(t){const o=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(function(t){return r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,r.or(i._`${t}.instancePath === ${w}`,r.and(i._`${t}.instancePath.indexOf(${w}) === 0`,i._`${t}.instancePath[${w}.length] === "/"`)),i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${t}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(t),(()=>n.code(i._`${o}.push(${t})`).assign(i._`${t}.${h}`,!0))))),n.if(i._`${o}.length`,(()=>a.reportError(e,{message:S(t),params:i._`{errors: ${o}}`})))}(o),t.keepErrors||function(){const t=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(i._`!${e}.${h}`,(()=>n.code(i._`${t}.push(${e})`))))),n.assign(l.default.vErrors,t).assign(l.default.errors,i._`${t}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(e))};e.default=f,t.exports=f,t.exports.default=f},7433:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv2020=void 0;const i=n(4042),r=n(6105),o=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(t={}){super({...t,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:t,meta:e}=this.opts;e&&(s.default.call(this,t),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}e.Ajv2020=l,t.exports=e=l,t.exports.Ajv2020=l,Object.defineProperty(e,"__esModule",{value:!0}),e.default=l;var c=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var h=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var u=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return u.default}});var d=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv=void 0;const i=n(4042),r=n(6144),o=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const t=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(t,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}e.Ajv=c,t.exports=e=c,t.exports.Ajv=c,Object.defineProperty(e,"__esModule",{value:!0}),e.default=c;var h=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return h.KeywordCxt}});var u=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var d=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.regexpCode=e.getEsmExportName=e.getProperty=e.safeStringify=e.stringify=e.strConcat=e.addCodeArg=e.str=e._=e.nil=e._Code=e.Name=e.IDENTIFIER=e._CodeOrName=void 0;class n{}e._CodeOrName=n,e.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(t){if(super(),!e.IDENTIFIER.test(t))throw new Error("CodeGen: name must be a valid identifier");this.str=t}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}e.Name=i;class r extends n{constructor(t){super(),this._items="string"==typeof t?[t]:t}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const t=this._items[0];return""===t||'""'===t}get str(){var t;return null!==(t=this._str)&&void 0!==t?t:this._str=this._items.reduce(((t,e)=>`${t}${e}`),"")}get names(){var t;return null!==(t=this._names)&&void 0!==t?t:this._names=this._items.reduce(((t,e)=>(e instanceof i&&(t[e.str]=(t[e.str]||0)+1),t)),{})}}function o(t,...e){const n=[t[0]];let i=0;for(;i<e.length;)l(n,e[i]),n.push(t[++i]);return new r(n)}e._Code=r,e.nil=new r(""),e._=o;const s=new r("+");function a(t,...e){const n=[h(t[0])];let i=0;for(;i<e.length;)n.push(s),l(n,e[i]),n.push(s,h(t[++i]));return function(t){let e=1;for(;e<t.length-1;){if(t[e]===s){const n=c(t[e-1],t[e+1]);if(void 0!==n){t.splice(e-1,3,n);continue}t[e++]="+"}e++}}(n),new r(n)}function l(t,e){var n;e instanceof r?t.push(...e._items):e instanceof i?t.push(e):t.push("number"==typeof(n=e)||"boolean"==typeof n||null===n?n:h(Array.isArray(n)?n.join(","):n))}function c(t,e){if('""'===e)return t;if('""'===t)return e;if("string"==typeof t){if(e instanceof i||'"'!==t[t.length-1])return;return"string"!=typeof e?`${t.slice(0,-1)}${e}"`:'"'===e[0]?t.slice(0,-1)+e.slice(1):void 0}return"string"!=typeof e||'"'!==e[0]||t instanceof i?void 0:`"${t}${e.slice(1)}`}function h(t){return JSON.stringify(t).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}e.str=a,e.addCodeArg=l,e.strConcat=function(t,e){return e.emptyStr()?t:t.emptyStr()?e:a`${t}${e}`},e.stringify=function(t){return new r(h(t))},e.safeStringify=h,e.getProperty=function(t){return"string"==typeof t&&e.IDENTIFIER.test(t)?new r(`.${t}`):o`[${t}]`},e.getEsmExportName=function(t){if("string"==typeof t&&e.IDENTIFIER.test(t))return new r(`${t}`);throw new Error(`CodeGen: invalid export name: ${t}, use explicit $id name mapping`)},e.regexpCode=function(t){return new r(t.toString())}},9029:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.or=e.and=e.not=e.CodeGen=e.operators=e.varKinds=e.ValueScopeName=e.ValueScope=e.Scope=e.Name=e.regexpCode=e.stringify=e.getProperty=e.nil=e.strConcat=e.str=e._=void 0;const i=n(1520),r=n(7845);var o=n(1520);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(e,"strConcat",{enumerable:!0,get:function(){return o.strConcat}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(e,"getProperty",{enumerable:!0,get:function(){return o.getProperty}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(e,"regexpCode",{enumerable:!0,get:function(){return o.regexpCode}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return o.Name}});var s=n(7845);Object.defineProperty(e,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(e,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(e,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(e,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),e.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(t,e){return this}}class l extends a{constructor(t,e,n){super(),this.varKind=t,this.name=e,this.rhs=n}render({es5:t,_n:e}){const n=t?r.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+e}optimizeNames(t,e){if(t[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,t,e)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(t,e,n){super(),this.lhs=t,this.rhs=e,this.sideEffects=n}render({_n:t}){return`${this.lhs} = ${this.rhs};`+t}optimizeNames(t,e){if(!(this.lhs instanceof i.Name)||t[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,t,e),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class h extends c{constructor(t,e,n,i){super(t,n,i),this.op=e}render({_n:t}){return`${this.lhs} ${this.op}= ${this.rhs};`+t}}class u extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`${this.label}:`+t}}class d extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`break${this.label?` ${this.label}`:""};`+t}}class p extends a{constructor(t){super(),this.error=t}render({_n:t}){return`throw ${this.error};`+t}get names(){return this.error.names}}class m extends a{constructor(t){super(),this.code=t}render({_n:t}){return`${this.code};`+t}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(t,e){return this.code=N(this.code,t,e),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class f extends a{constructor(t=[]){super(),this.nodes=t}render(t){return this.nodes.reduce(((e,n)=>e+n.render(t)),"")}optimizeNodes(){const{nodes:t}=this;let e=t.length;for(;e--;){const n=t[e].optimizeNodes();Array.isArray(n)?t.splice(e,1,...n):n?t[e]=n:t.splice(e,1)}return t.length>0?this:void 0}optimizeNames(t,e){const{nodes:n}=this;let i=n.length;for(;i--;){const r=n[i];r.optimizeNames(t,e)||(P(t,r.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((t,e)=>T(t,e.names)),{})}}class g extends f{render(t){return"{"+t._n+super.render(t)+"}"+t._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(t,e){super(e),this.condition=t}render(t){let e=`if(${this.condition})`+super.render(t);return this.else&&(e+="else "+this.else.render(t)),e}optimizeNodes(){super.optimizeNodes();const t=this.condition;if(!0===t)return this.nodes;let e=this.else;if(e){const t=e.optimizeNodes();e=this.else=Array.isArray(t)?new b(t):t}return e?!1===t?e instanceof v?e:e.nodes:this.nodes.length?this:new v($(t),e instanceof v?[e]:e.nodes):!1!==t&&this.nodes.length?this:void 0}optimizeNames(t,e){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(t,e),super.optimizeNames(t,e)||this.else)return this.condition=N(this.condition,t,e),this}get names(){const t=super.names;return L(t,this.condition),this.else&&T(t,this.else.names),t}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(t){super(),this.iteration=t}render(t){return`for(${this.iteration})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iteration=N(this.iteration,t,e),this}get names(){return T(super.names,this.iteration.names)}}class A extends w{constructor(t,e,n,i){super(),this.varKind=t,this.name=e,this.from=n,this.to=i}render(t){const e=t.es5?r.varKinds.var:this.varKind,{name:n,from:i,to:o}=this;return`for(${e} ${n}=${i}; ${n}<${o}; ${n}++)`+super.render(t)}get names(){const t=L(super.names,this.from);return L(t,this.to)}}class S extends w{constructor(t,e,n,i){super(),this.loop=t,this.varKind=e,this.name=n,this.iterable=i}render(t){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iterable=N(this.iterable,t,e),this}get names(){return T(super.names,this.iterable.names)}}class x extends g{constructor(t,e,n){super(),this.name=t,this.args=e,this.async=n}render(t){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(t)}}x.kind="func";class E extends f{render(t){return"return "+super.render(t)}}E.kind="return";class M extends g{render(t){let e="try"+super.render(t);return this.catch&&(e+=this.catch.render(t)),this.finally&&(e+=this.finally.render(t)),e}optimizeNodes(){var t,e;return super.optimizeNodes(),null===(t=this.catch)||void 0===t||t.optimizeNodes(),null===(e=this.finally)||void 0===e||e.optimizeNodes(),this}optimizeNames(t,e){var n,i;return super.optimizeNames(t,e),null===(n=this.catch)||void 0===n||n.optimizeNames(t,e),null===(i=this.finally)||void 0===i||i.optimizeNames(t,e),this}get names(){const t=super.names;return this.catch&&T(t,this.catch.names),this.finally&&T(t,this.finally.names),t}}class _ extends g{constructor(t){super(),this.error=t}render(t){return`catch(${this.error})`+super.render(t)}}_.kind="catch";class I extends g{render(t){return"finally"+super.render(t)}}function T(t,e){for(const n in e)t[n]=(t[n]||0)+(e[n]||0);return t}function L(t,e){return e instanceof i._CodeOrName?T(t,e.names):t}function N(t,e,n){return t instanceof i.Name?o(t):(r=t)instanceof i._Code&&r._items.some((t=>t instanceof i.Name&&1===e[t.str]&&void 0!==n[t.str]))?new i._Code(t._items.reduce(((t,e)=>(e instanceof i.Name&&(e=o(e)),e instanceof i._Code?t.push(...e._items):t.push(e),t)),[])):t;var r;function o(t){const i=n[t.str];return void 0===i||1!==e[t.str]?t:(delete e[t.str],i)}}function P(t,e){for(const n in e)t[n]=(t[n]||0)-(e[n]||0)}function $(t){return"boolean"==typeof t||"number"==typeof t||null===t?!t:i._`!${G(t)}`}I.kind="finally",e.CodeGen=class{constructor(t,e={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...e,_n:e.lines?"\n":""},this._extScope=t,this._scope=new r.Scope({parent:t}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(t){return this._scope.name(t)}scopeName(t){return this._extScope.name(t)}scopeValue(t,e){const n=this._extScope.value(t,e);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(t,e){return this._extScope.getValue(t,e)}scopeRefs(t){return this._extScope.scopeRefs(t,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(t,e,n,i){const r=this._scope.toName(e);return void 0!==n&&i&&(this._constants[r.str]=n),this._leafNode(new l(t,r,n)),r}const(t,e,n){return this._def(r.varKinds.const,t,e,n)}let(t,e,n){return this._def(r.varKinds.let,t,e,n)}var(t,e,n){return this._def(r.varKinds.var,t,e,n)}assign(t,e,n){return this._leafNode(new c(t,e,n))}add(t,n){return this._leafNode(new h(t,e.operators.ADD,n))}code(t){return"function"==typeof t?t():t!==i.nil&&this._leafNode(new m(t)),this}object(...t){const e=["{"];for(const[n,r]of t)e.length>1&&e.push(","),e.push(n),(n!==r||this.opts.es5)&&(e.push(":"),(0,i.addCodeArg)(e,r));return e.push("}"),new i._Code(e)}if(t,e,n){if(this._blockNode(new v(t)),e&&n)this.code(e).else().code(n).endIf();else if(e)this.code(e).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(t){return this._elseNode(new v(t))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(t,e){return this._blockNode(t),e&&this.code(e).endFor(),this}for(t,e){return this._for(new C(t),e)}forRange(t,e,n,i,o=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const s=this._scope.toName(t);return this._for(new A(o,s,e,n),(()=>i(s)))}forOf(t,e,n,o=r.varKinds.const){const s=this._scope.toName(t);if(this.opts.es5){const t=e instanceof i.Name?e:this.var("_arr",e);return this.forRange("_i",0,i._`${t}.length`,(e=>{this.var(s,i._`${t}[${e}]`),n(s)}))}return this._for(new S("of",o,s,e),(()=>n(s)))}forIn(t,e,n,o=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(t,i._`Object.keys(${e})`,n);const s=this._scope.toName(t);return this._for(new S("in",o,s,e),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(t){return this._leafNode(new u(t))}break(t){return this._leafNode(new d(t))}return(t){const e=new E;if(this._blockNode(e),this.code(t),1!==e.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(t,e,n){if(!e&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new M;if(this._blockNode(i),this.code(t),e){const t=this.name("e");this._currNode=i.catch=new _(t),e(t)}return n&&(this._currNode=i.finally=new I,this.code(n)),this._endBlockNode(_,I)}throw(t){return this._leafNode(new p(t))}block(t,e){return this._blockStarts.push(this._nodes.length),t&&this.code(t).endBlock(e),this}endBlock(t){const e=this._blockStarts.pop();if(void 0===e)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-e;if(n<0||void 0!==t&&n!==t)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${t} expected`);return this._nodes.length=e,this}func(t,e=i.nil,n,r){return this._blockNode(new x(t,e,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(t=1){for(;t-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(t){return this._currNode.nodes.push(t),this}_blockNode(t){this._currNode.nodes.push(t),this._nodes.push(t)}_endBlockNode(t,e){const n=this._currNode;if(n instanceof t||e&&n instanceof e)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${e?`${t.kind}/${e.kind}`:t.kind}"`)}_elseNode(t){const e=this._currNode;if(!(e instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=e.else=t,this}get _root(){return this._nodes[0]}get _currNode(){const t=this._nodes;return t[t.length-1]}set _currNode(t){const e=this._nodes;e[e.length-1]=t}},e.not=$;const R=k(e.operators.AND);e.and=function(...t){return t.reduce(R)};const O=k(e.operators.OR);function k(t){return(e,n)=>e===i.nil?n:n===i.nil?e:i._`${G(e)} ${t} ${G(n)}`}function G(t){return t instanceof i.Name?t:i._`(${t})`}e.or=function(...t){return t.reduce(O)}},7845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.ValueScope=e.ValueScopeName=e.Scope=e.varKinds=e.UsedValueState=void 0;const i=n(1520);class r extends Error{constructor(t){super(`CodeGen: "code" for ${t} not defined`),this.value=t.value}}var o;!function(t){t[t.Started=0]="Started",t[t.Completed=1]="Completed"}(o||(e.UsedValueState=o={})),e.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:t,parent:e}={}){this._names={},this._prefixes=t,this._parent=e}toName(t){return t instanceof i.Name?t:this.name(t)}name(t){return new i.Name(this._newName(t))}_newName(t){return`${t}${(this._names[t]||this._nameGroup(t)).index++}`}_nameGroup(t){var e,n;if((null===(n=null===(e=this._parent)||void 0===e?void 0:e._prefixes)||void 0===n?void 0:n.has(t))||this._prefixes&&!this._prefixes.has(t))throw new Error(`CodeGen: prefix "${t}" is not allowed in this scope`);return this._names[t]={prefix:t,index:0}}}e.Scope=s;class a extends i.Name{constructor(t,e){super(e),this.prefix=t}setValue(t,{property:e,itemIndex:n}){this.value=t,this.scopePath=i._`.${new i.Name(e)}[${n}]`}}e.ValueScopeName=a;const l=i._`\n`;e.ValueScope=class extends s{constructor(t){super(t),this._values={},this._scope=t.scope,this.opts={...t,_n:t.lines?l:i.nil}}get(){return this._scope}name(t){return new a(t,this._newName(t))}value(t,e){var n;if(void 0===e.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(t),{prefix:r}=i,o=null!==(n=e.key)&&void 0!==n?n:e.ref;let s=this._values[r];if(s){const t=s.get(o);if(t)return t}else s=this._values[r]=new Map;s.set(o,i);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=e.ref,i.setValue(e,{property:r,itemIndex:l}),i}getValue(t,e){const n=this._values[t];if(n)return n.get(e)}scopeRefs(t,e=this._values){return this._reduceValues(e,(e=>{if(void 0===e.scopePath)throw new Error(`CodeGen: name "${e}" has no value`);return i._`${t}${e.scopePath}`}))}scopeCode(t=this._values,e,n){return this._reduceValues(t,(t=>{if(void 0===t.value)throw new Error(`CodeGen: name "${t}" has no value`);return t.value.code}),e,n)}_reduceValues(t,n,s={},a){let l=i.nil;for(const c in t){const h=t[c];if(!h)continue;const u=s[c]=s[c]||new Map;h.forEach((t=>{if(u.has(t))return;u.set(t,o.Started);let s=n(t);if(s){const n=this.opts.es5?e.varKinds.var:e.varKinds.const;l=i._`${l}${n} ${t} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(t)))throw new r(t);l=i._`${l}${s}${this.opts._n}`}u.set(t,o.Completed)}))}return l}}},8708:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.extendErrors=e.resetErrorsCount=e.reportExtraError=e.reportError=e.keyword$DataError=e.keywordError=void 0;const i=n(9029),r=n(4227),o=n(2023);function s(t,e){const n=t.const("err",e);t.if(i._`${o.default.vErrors} === null`,(()=>t.assign(o.default.vErrors,i._`[${n}]`)),i._`${o.default.vErrors}.push(${n})`),t.code(i._`${o.default.errors}++`)}function a(t,e){const{gen:n,validateName:r,schemaEnv:o}=t;o.$async?n.throw(i._`new ${t.ValidationError}(${e})`):(n.assign(i._`${r}.errors`,e),n.return(!1))}e.keywordError={message:({keyword:t})=>i.str`must pass "${t}" keyword validation`},e.keyword$DataError={message:({keyword:t,schemaType:e})=>e?i.str`"${t}" keyword must be ${e} ($data)`:i.str`"${t}" keyword is invalid ($data)`},e.reportError=function(t,n=e.keywordError,r,o){const{it:l}=t,{gen:h,compositeRule:u,allErrors:d}=l,p=c(t,n,r);(null!=o?o:u||d)?s(h,p):a(l,i._`[${p}]`)},e.reportExtraError=function(t,n=e.keywordError,i){const{it:r}=t,{gen:l,compositeRule:h,allErrors:u}=r;s(l,c(t,n,i)),h||u||a(r,o.default.vErrors)},e.resetErrorsCount=function(t,e){t.assign(o.default.errors,e),t.if(i._`${o.default.vErrors} !== null`,(()=>t.if(e,(()=>t.assign(i._`${o.default.vErrors}.length`,e)),(()=>t.assign(o.default.vErrors,null)))))},e.extendErrors=function({gen:t,keyword:e,schemaValue:n,data:r,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=t.name("err");t.forRange("i",s,o.default.errors,(s=>{t.const(l,i._`${o.default.vErrors}[${s}]`),t.if(i._`${l}.instancePath === undefined`,(()=>t.assign(i._`${l}.instancePath`,(0,i.strConcat)(o.default.instancePath,a.errorPath)))),t.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${e}`),a.opts.verbose&&(t.assign(i._`${l}.schema`,n),t.assign(i._`${l}.data`,r))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(t,e,n){const{createErrors:r}=t.it;return!1===r?i._`{}`:function(t,e,n={}){const{gen:r,it:s}=t,a=[h(s,n),u(t,n)];return function(t,{params:e,message:n},r){const{keyword:s,data:a,schemaValue:c,it:h}=t,{opts:u,propertyName:d,topSchemaRef:p,schemaPath:m}=h;r.push([l.keyword,s],[l.params,"function"==typeof e?e(t):e||i._`{}`]),u.messages&&r.push([l.message,"function"==typeof n?n(t):n]),u.verbose&&r.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[o.default.data,a]),d&&r.push([l.propertyName,d])}(t,e,a),r.object(...a)}(t,e,n)}function h({errorPath:t},{instancePath:e}){const n=e?i.str`${t}${(0,r.getErrorPath)(e,r.Type.Str)}`:t;return[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,n)]}function u({keyword:t,it:{errSchemaPath:e}},{schemaPath:n,parentSchema:o}){let s=o?e:i.str`${e}/${t}`;return n&&(s=i.str`${s}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,s]}},3835:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.resolveSchema=e.getCompilingSchema=e.resolveRef=e.compileSchema=e.SchemaEnv=void 0;const i=n(9029),r=n(3558),o=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(t){var e;let n;this.refs={},this.dynamicAnchors={},"object"==typeof t.schema&&(n=t.schema),this.schema=t.schema,this.schemaId=t.schemaId,this.root=t.root||this,this.baseId=null!==(e=t.baseId)&&void 0!==e?e:(0,s.normalizeId)(null==n?void 0:n[t.schemaId||"$id"]),this.schemaPath=t.schemaPath,this.localRefs=t.localRefs,this.meta=t.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function h(t){const e=d.call(this,t);if(e)return e;const n=(0,s.getFullPath)(this.opts.uriResolver,t.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:h}=this.opts,u=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:h});let p;t.$async&&(p=u.scopeValue("Error",{ref:r.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=u.scopeName("validate");t.validateName=m;const f={gen:u,allErrors:this.opts.allErrors,data:o.default.data,parentData:o.default.parentData,parentDataProperty:o.default.parentDataProperty,dataNames:[o.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:u.scopeValue("schema",!0===this.opts.code.source?{ref:t.schema,code:(0,i.stringify)(t.schema)}:{ref:t.schema}),validateName:m,ValidationError:p,schema:t.schema,schemaEnv:t,rootId:n,baseId:t.baseId||n,schemaPath:i.nil,errSchemaPath:t.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(t),(0,l.validateFunctionCode)(f),u.optimize(this.opts.code.optimize);const e=u.toString();g=`${u.scopeRefs(o.default.scope)}return ${e}`,this.opts.code.process&&(g=this.opts.code.process(g,t));const n=new Function(`${o.default.self}`,`${o.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=t.schema,n.schemaEnv=t,t.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:e,scopeValues:u._values}),this.opts.unevaluated){const{props:t,items:e}=f;n.evaluated={props:t instanceof i.Name?void 0:t,items:e instanceof i.Name?void 0:e,dynamicProps:t instanceof i.Name,dynamicItems:e instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return t.validate=n,t}catch(e){throw delete t.validate,delete t.validateName,g&&this.logger.error("Error compiling schema, function code:",g),e}finally{this._compilations.delete(t)}}function u(t){return(0,s.inlineRef)(t.schema,this.opts.inlineRefs)?t.schema:t.validate?t:h.call(this,t)}function d(t){for(const i of this._compilations)if(n=t,(e=i).schema===n.schema&&e.root===n.root&&e.baseId===n.baseId)return i;var e,n}function p(t,e){let n;for(;"string"==typeof(n=this.refs[e]);)e=n;return n||this.schemas[e]||m.call(this,t,e)}function m(t,e){const n=this.opts.uriResolver.parse(e),i=(0,s._getFullPath)(this.opts.uriResolver,n);let r=(0,s.getFullPath)(this.opts.uriResolver,t.baseId,void 0);if(Object.keys(t.schema).length>0&&i===r)return g.call(this,n,t);const o=(0,s.normalizeId)(i),a=this.refs[o]||this.schemas[o];if("string"==typeof a){const e=m.call(this,t,a);if("object"!=typeof(null==e?void 0:e.schema))return;return g.call(this,n,e)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||h.call(this,a),o===(0,s.normalizeId)(e)){const{schema:e}=a,{schemaId:n}=this.opts,i=e[n];return i&&(r=(0,s.resolveUrl)(this.opts.uriResolver,r,i)),new c({schema:e,schemaId:n,root:t,baseId:r})}return g.call(this,n,a)}}e.SchemaEnv=c,e.compileSchema=h,e.resolveRef=function(t,e,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,e,n);const r=t.refs[n];if(r)return r;let o=p.call(this,t,n);if(void 0===o){const r=null===(i=t.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;r&&(o=new c({schema:r,schemaId:s,root:t,baseId:e}))}return void 0!==o?t.refs[n]=u.call(this,o):void 0},e.getCompilingSchema=d,e.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(t,{baseId:e,schema:n,root:i}){var r;if("/"!==(null===(r=t.fragment)||void 0===r?void 0:r[0]))return;for(const i of t.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const t=n[(0,a.unescapeFragment)(i)];if(void 0===t)return;const r="object"==typeof(n=t)&&n[this.opts.schemaId];!f.has(i)&&r&&(e=(0,s.resolveUrl)(this.opts.uriResolver,e,r))}let o;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const t=(0,s.resolveUrl)(this.opts.uriResolver,e,n.$ref);o=m.call(this,i,t)}const{schemaId:l}=this.opts;return o=o||new c({schema:n,schemaId:l,root:i,baseId:e}),o.schema!==o.root.schema?o:void 0}},2023:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};e.default=r},4551:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(6939);class r extends Error{constructor(t,e,n,r){super(r||`can't resolve reference ${n} from id ${e}`),this.missingRef=(0,i.resolveUrl)(t,e,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(t,this.missingRef))}}e.default=r},6939:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getSchemaRefs=e.resolveUrl=e.normalizeId=e._getFullPath=e.getFullPath=e.inlineRef=void 0;const i=n(4227),r=n(2017),o=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);e.inlineRef=function(t,e=!0){return"boolean"==typeof t||(!0===e?!l(t):!!e&&c(t)<=e)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(t){for(const e in t){if(a.has(e))return!0;const n=t[e];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(t){let e=0;for(const n in t){if("$ref"===n)return 1/0;if(e++,!s.has(n)&&("object"==typeof t[n]&&(0,i.eachItem)(t[n],(t=>e+=c(t))),e===1/0))return 1/0}return e}function h(t,e="",n){!1!==n&&(e=p(e));const i=t.parse(e);return u(t,i)}function u(t,e){return t.serialize(e).split("#")[0]+"#"}e.getFullPath=h,e._getFullPath=u;const d=/#\/?$/;function p(t){return t?t.replace(d,""):""}e.normalizeId=p,e.resolveUrl=function(t,e,n){return n=p(n),t.resolve(e,n)};const m=/^[a-z_][-a-z0-9._]*$/i;e.getSchemaRefs=function(t,e){if("boolean"==typeof t)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(t[n]||e),a={"":s},l=h(i,s,!1),c={},u=new Set;return o(t,{allKeys:!0},((t,e,i,r)=>{if(void 0===r)return;const o=l+e;let s=a[r];function h(e){const n=this.opts.uriResolver.resolve;if(e=p(s?n(s,e):e),u.has(e))throw f(e);u.add(e);let i=this.refs[e];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(t,i.schema,e):e!==p(o)&&("#"===e[0]?(d(t,c[e],e),c[e]=t):this.refs[e]=o),e}function g(t){if("string"==typeof t){if(!m.test(t))throw new Error(`invalid anchor "${t}"`);h.call(this,`#${t}`)}}"string"==typeof t[n]&&(s=h.call(this,t[n])),g.call(this,t.$anchor),g.call(this,t.$dynamicAnchor),a[e]=s})),c;function d(t,e,n){if(void 0!==e&&!r(t,e))throw f(n)}function f(t){return new Error(`reference "${t}" resolves to more than one schema`)}}},396:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getRules=e.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);e.isJSONType=function(t){return"string"==typeof t&&n.has(t)},e.getRules=function(){const t={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...t,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},t.number,t.string,t.array,t.object],post:{rules:[]},all:{},keywords:{}}}},4227:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.checkStrictMode=e.getErrorPath=e.Type=e.useFunc=e.setEvaluated=e.evaluatedPropsToName=e.mergeEvaluated=e.eachItem=e.unescapeJsonPointer=e.escapeJsonPointer=e.escapeFragment=e.unescapeFragment=e.schemaRefOrVal=e.schemaHasRulesButRef=e.schemaHasRules=e.checkUnknownRules=e.alwaysValidSchema=e.toHash=void 0;const i=n(9029),r=n(1520);function o(t,e=t.schema){const{opts:n,self:i}=t;if(!n.strictSchema)return;if("boolean"==typeof e)return;const r=i.RULES.keywords;for(const n in e)r[n]||m(t,`unknown keyword: "${n}"`)}function s(t,e){if("boolean"==typeof t)return!t;for(const n in t)if(e[n])return!0;return!1}function a(t){return"number"==typeof t?`${t}`:t.replace(/~/g,"~0").replace(/\//g,"~1")}function l(t){return t.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:t,mergeToName:e,mergeValues:n,resultToName:r}){return(o,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?t(o,s,a):e(o,s,a),a):s instanceof i.Name?(e(o,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:r(o,c)}}function h(t,e){if(!0===e)return t.var("props",!0);const n=t.var("props",i._`{}`);return void 0!==e&&u(t,n,e),n}function u(t,e,n){Object.keys(n).forEach((n=>t.assign(i._`${e}${(0,i.getProperty)(n)}`,!0)))}e.toHash=function(t){const e={};for(const n of t)e[n]=!0;return e},e.alwaysValidSchema=function(t,e){return"boolean"==typeof e?e:0===Object.keys(e).length||(o(t,e),!s(e,t.self.RULES.all))},e.checkUnknownRules=o,e.schemaHasRules=s,e.schemaHasRulesButRef=function(t,e){if("boolean"==typeof t)return!t;for(const n in t)if("$ref"!==n&&e.all[n])return!0;return!1},e.schemaRefOrVal=function({topSchemaRef:t,schemaPath:e},n,r,o){if(!o){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${t}${e}${(0,i.getProperty)(r)}`},e.unescapeFragment=function(t){return l(decodeURIComponent(t))},e.escapeFragment=function(t){return encodeURIComponent(a(t))},e.escapeJsonPointer=a,e.unescapeJsonPointer=l,e.eachItem=function(t,e){if(Array.isArray(t))for(const n of t)e(n);else e(t)},e.mergeEvaluated={props:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>{t.if(i._`${e} === true`,(()=>t.assign(n,!0)),(()=>t.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${e})`)))})),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>{!0===e?t.assign(n,!0):(t.assign(n,i._`${n} || {}`),u(t,n,e))})),mergeValues:(t,e)=>!0===t||{...t,...e},resultToName:h}),items:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>t.assign(n,i._`${e} === true ? true : ${n} > ${e} ? ${n} : ${e}`))),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>t.assign(n,!0===e||i._`${n} > ${e} ? ${n} : ${e}`))),mergeValues:(t,e)=>!0===t||Math.max(t,e),resultToName:(t,e)=>t.var("items",e)})},e.evaluatedPropsToName=h,e.setEvaluated=u;const d={};var p;function m(t,e,n=t.opts.strictSchema){if(n){if(e=`strict mode: ${e}`,!0===n)throw new Error(e);t.self.logger.warn(e)}}e.useFunc=function(t,e){return t.scopeValue("func",{ref:e,code:d[e.code]||(d[e.code]=new r._Code(e.code))})},function(t){t[t.Num=0]="Num",t[t.Str=1]="Str"}(p||(e.Type=p={})),e.getErrorPath=function(t,e,n){if(t instanceof i.Name){const r=e===p.Num;return n?r?i._`"[" + ${t} + "]"`:i._`"['" + ${t} + "']"`:r?i._`"/" + ${t}`:i._`"/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(t).toString():"/"+a(t)},e.checkStrictMode=m},7887:(t,e)=>{"use strict";function n(t,e){return e.rules.some((e=>i(t,e)))}function i(t,e){var n;return void 0!==t[e.keyword]||(null===(n=e.definition.implements)||void 0===n?void 0:n.some((e=>void 0!==t[e])))}Object.defineProperty(e,"__esModule",{value:!0}),e.shouldUseRule=e.shouldUseGroup=e.schemaHasRulesForType=void 0,e.schemaHasRulesForType=function({schema:t,self:e},i){const r=e.RULES.types[i];return r&&!0!==r&&n(t,r)},e.shouldUseGroup=n,e.shouldUseRule=i},8727:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.boolOrEmptySchema=e.topBoolOrEmptySchema=void 0;const i=n(8708),r=n(9029),o=n(2023),s={message:"boolean schema is false"};function a(t,e){const{gen:n,data:r}=t,o={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:t};(0,i.reportError)(o,s,void 0,e)}e.topBoolOrEmptySchema=function(t){const{gen:e,schema:n,validateName:i}=t;!1===n?a(t,!1):"object"==typeof n&&!0===n.$async?e.return(o.default.data):(e.assign(r._`${i}.errors`,null),e.return(!0))},e.boolOrEmptySchema=function(t,e){const{gen:n,schema:i}=t;!1===i?(n.var(e,!1),a(t)):n.var(e,!0)}},208:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.reportTypeError=e.checkDataTypes=e.checkDataType=e.coerceAndCheckDataType=e.getJSONTypes=e.getSchemaTypes=e.DataType=void 0;const i=n(396),r=n(7887),o=n(8708),s=n(9029),a=n(4227);var l;function c(t){const e=Array.isArray(t)?t:t?[t]:[];if(e.every(i.isJSONType))return e;throw new Error("type must be JSONType or JSONType[]: "+e.join(","))}!function(t){t[t.Correct=0]="Correct",t[t.Wrong=1]="Wrong"}(l||(e.DataType=l={})),e.getSchemaTypes=function(t){const e=c(t.type);if(e.includes("null")){if(!1===t.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!e.length&&void 0!==t.nullable)throw new Error('"nullable" cannot be used without "type"');!0===t.nullable&&e.push("null")}return e},e.getJSONTypes=c,e.coerceAndCheckDataType=function(t,e){const{gen:n,data:i,opts:o}=t,a=function(t,e){return e?t.filter((t=>h.has(t)||"array"===e&&"array"===t)):[]}(e,o.coerceTypes),c=e.length>0&&!(0===a.length&&1===e.length&&(0,r.schemaHasRulesForType)(t,e[0]));if(c){const r=d(e,i,o.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(t,e,n){const{gen:i,data:r,opts:o}=t,a=i.let("dataType",s._`typeof ${r}`),l=i.let("coerced",s._`undefined`);"array"===o.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>i.assign(r,s._`${r}[0]`).assign(a,s._`typeof ${r}`).if(d(e,r,o.strictNumbers),(()=>i.assign(l,r))))),i.if(s._`${l} !== undefined`);for(const t of n)(h.has(t)||"array"===t&&"array"===o.coerceTypes)&&c(t);function c(t){switch(t){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${r}`).elseIf(s._`${r} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${r} === null
+var bio;(()=>{var t={8924:(t,e,n)=>{"use strict";var i=n(7362);class r extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in r.aaSynonyms?r.aaSynonyms[t]:t;return super.get(e)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(t="grok"){switch(t){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,n="",i="";for(const r of t)"("==r?e++:")"==r?e--:e?n+=r:i+=r;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(t="",e="grok"){const n=this.getPalette(e);let[i,r]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,r=r.length>6?`${r.slice(0,3)}...`:r,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in n?[n.get(e),e,r,1]:[this.undefinedColor,i,r,1]}if("d"==t[0]&&t[1]in n&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in n?[n.get(e),e,r,2]:[this.undefinedColor,i,r,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in n?[n.get(e),e,r,3]:[this.undefinedColor,i,r,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in n?[n.get(e),e,r,4]:[this.undefinedColor,i,r,4]}return[this.undefinedColor,i,r,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(t,e,n)=>{"use strict";n.d(e,{j:()=>r});var i=n(6082);async function r(){const t=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===t.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await t[0].prepare().call()).getOutputParamValue()}},3599:(t,e,n)=>{"use strict";n.d(e,{o:()=>i.o});var i=n(6869)},9124:(t,e,n)=>{"use strict";n.d(e,{b2:()=>o,fA:()=>s});var i=n(7389),r=n(6082);async function o(){const t="Helm",e=r.Func.find({package:t,name:"getHelmHelper"});if(0===e.length)throw new Error(`Package '${t}' must be installed for HelmHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}function s(t,e){if(!t)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const r=t;return"ATOM"===r.T?(n=r.biotype(),i=r.elem):(n=t,i=e),[n,i]}r.JsInputBase,Error,i.input.helmAsync=async function(t,e){return(await o()).createHelmInput(t,e)}},8438:(t,e,n)=>{"use strict";function i(t){return t.startsWith("[")&&t.endsWith("]")?t.slice(1,-1):t}n.d(e,{D:()=>i})},8123:(t,e,n)=>{"use strict";n.d(e,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M  RGP",V2K_A_LINE:"A  ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:"  0  0  0  0  0  0            999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M  V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M  V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M  V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M  V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M  V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M  V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M  V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M  V30 ",V3K_END:"M  END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(t,e,n)=>{"use strict";n.d(e,{Eu:()=>a,ub:()=>s});var i=n(4328);const r="Libraries";let o=Promise.resolve();async function s(){let t;return o=o.then((async()=>{const e=i.userSettings.getValue(r,"Settings",!0);t=e?JSON.parse(e):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},t.exclude=t.exclude instanceof Array?t.exclude:[],t.explicit=t.explicit instanceof Array?t.explicit:[],t.duplicateMonomerPreferences=t.duplicateMonomerPreferences instanceof Object?t.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await o,t}async function a(t){o=o.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),i.userSettings.add(r,"Settings",JSON.stringify(t),!0)})),await o}},5553:(t,e,n)=>{"use strict";n.d(e,{Qc:()=>A,WN:()=>S});var i=n(1991),r=n.n(i);const o="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(t,e,n,i)=>{"function"==typeof a.emitWarning?a.emitWarning(t,e,n,i):console.error(`[${n}] ${e}: ${t}`)};let c=globalThis.AbortController,h=globalThis.AbortSignal;if(void 0===c){h=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(t,e){this._onabort.push(e)}},c=class{constructor(){e()}signal=new h;abort(t){if(!this.signal.aborted){this.signal.reason=t,this.signal.aborted=!0;for(const e of this.signal._onabort)e(t);this.signal.onabort?.(t)}}};let t="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const e=()=>{t&&(t=!1,l("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). You may disable this with LRU_CACHE_IGNORE_AC_WARNING=1 in the env.","NO_ABORT_CONTROLLER","ENOTSUP",e))}}Symbol("type");const u=t=>t&&t===Math.floor(t)&&t>0&&isFinite(t),d=t=>u(t)?t<=Math.pow(2,8)?Uint8Array:t<=Math.pow(2,16)?Uint16Array:t<=Math.pow(2,32)?Uint32Array:t<=Number.MAX_SAFE_INTEGER?p:null:null;class p extends Array{constructor(t){super(t),this.fill(0)}}class m{heap;length;static#t=!1;static create(t){const e=d(t);if(!e)return[];m.#t=!0;const n=new m(t,e);return m.#t=!1,n}constructor(t,e){if(!m.#t)throw new TypeError("instantiate Stack using Stack.create(n)");this.heap=new e(t),this.length=0}push(t){this.heap[this.length++]=t}pop(){return this.heap[--this.length]}}class f{#e;#n;#i;#r;#o;#s;ttl;ttlResolution;ttlAutopurge;updateAgeOnGet;updateAgeOnHas;allowStale;noDisposeOnSet;noUpdateTTL;maxEntrySize;sizeCalculation;noDeleteOnFetchRejection;noDeleteOnStaleGet;allowStaleOnFetchAbort;allowStaleOnFetchRejection;ignoreFetchAbort;#a;#l;#c;#h;#u;#d;#p;#m;#f;#g;#y;#b;#v;#w;#C;#A;#S;static unsafeExposeInternals(t){return{starts:t.#v,ttls:t.#w,sizes:t.#b,keyMap:t.#c,keyList:t.#h,valList:t.#u,next:t.#d,prev:t.#p,get head(){return t.#m},get tail(){return t.#f},free:t.#g,isBackgroundFetch:e=>t.#x(e),backgroundFetch:(e,n,i,r)=>t.#E(e,n,i,r),moveToTail:e=>t.#M(e),indexes:e=>t.#_(e),rindexes:e=>t.#I(e),isStale:e=>t.#T(e)}}get max(){return this.#e}get maxSize(){return this.#n}get calculatedSize(){return this.#l}get size(){return this.#a}get fetchMethod(){return this.#o}get memoMethod(){return this.#s}get dispose(){return this.#i}get disposeAfter(){return this.#r}constructor(t){const{max:e=0,ttl:n,ttlResolution:i=1,ttlAutopurge:r,updateAgeOnGet:o,updateAgeOnHas:a,allowStale:c,dispose:h,disposeAfter:p,noDisposeOnSet:g,noUpdateTTL:y,maxSize:b=0,maxEntrySize:v=0,sizeCalculation:w,fetchMethod:C,memoMethod:A,noDeleteOnFetchRejection:S,noDeleteOnStaleGet:x,allowStaleOnFetchRejection:E,allowStaleOnFetchAbort:M,ignoreFetchAbort:_}=t;if(0!==e&&!u(e))throw new TypeError("max option must be a nonnegative integer");const I=e?d(e):Array;if(!I)throw new Error("invalid max value: "+e);if(this.#e=e,this.#n=b,this.maxEntrySize=v||this.#n,this.sizeCalculation=w,this.sizeCalculation){if(!this.#n&&!this.maxEntrySize)throw new TypeError("cannot set sizeCalculation without setting maxSize or maxEntrySize");if("function"!=typeof this.sizeCalculation)throw new TypeError("sizeCalculation set to non-function")}if(void 0!==A&&"function"!=typeof A)throw new TypeError("memoMethod must be a function if defined");if(this.#s=A,void 0!==C&&"function"!=typeof C)throw new TypeError("fetchMethod must be a function if specified");if(this.#o=C,this.#A=!!C,this.#c=new Map,this.#h=new Array(e).fill(void 0),this.#u=new Array(e).fill(void 0),this.#d=new I(e),this.#p=new I(e),this.#m=0,this.#f=0,this.#g=m.create(e),this.#a=0,this.#l=0,"function"==typeof h&&(this.#i=h),"function"==typeof p?(this.#r=p,this.#y=[]):(this.#r=void 0,this.#y=void 0),this.#C=!!this.#i,this.#S=!!this.#r,this.noDisposeOnSet=!!g,this.noUpdateTTL=!!y,this.noDeleteOnFetchRejection=!!S,this.allowStaleOnFetchRejection=!!E,this.allowStaleOnFetchAbort=!!M,this.ignoreFetchAbort=!!_,0!==this.maxEntrySize){if(0!==this.#n&&!u(this.#n))throw new TypeError("maxSize must be a positive integer if specified");if(!u(this.maxEntrySize))throw new TypeError("maxEntrySize must be a positive integer if specified");this.#L()}if(this.allowStale=!!c,this.noDeleteOnStaleGet=!!x,this.updateAgeOnGet=!!o,this.updateAgeOnHas=!!a,this.ttlResolution=u(i)||0===i?i:1,this.ttlAutopurge=!!r,this.ttl=n||0,this.ttl){if(!u(this.ttl))throw new TypeError("ttl must be a positive integer if specified");this.#N()}if(0===this.#e&&0===this.ttl&&0===this.#n)throw new TypeError("At least one of max, maxSize, or ttl is required");if(!this.ttlAutopurge&&!this.#e&&!this.#n){const t="LRU_CACHE_UNBOUNDED";(t=>!s.has(t))(t)&&(s.add(t),l("TTL caching without ttlAutopurge, max, or maxSize can result in unbounded memory consumption.","UnboundedCacheWarning",t,f))}}getRemainingTTL(t){return this.#c.has(t)?1/0:0}#N(){const t=new p(this.#e),e=new p(this.#e);this.#w=t,this.#v=e,this.#P=(n,i,r=o.now())=>{if(e[n]=0!==i?r:0,t[n]=i,0!==i&&this.ttlAutopurge){const t=setTimeout((()=>{this.#T(n)&&this.#$(this.#h[n],"expire")}),i+1);t.unref&&t.unref()}},this.#R=n=>{e[n]=0!==t[n]?o.now():0},this.#O=(r,o)=>{if(t[o]){const s=t[o],a=e[o];if(!s||!a)return;r.ttl=s,r.start=a,r.now=n||i();const l=r.now-a;r.remainingTTL=s-l}};let n=0;const i=()=>{const t=o.now();if(this.ttlResolution>0){n=t;const e=setTimeout((()=>n=0),this.ttlResolution);e.unref&&e.unref()}return t};this.getRemainingTTL=r=>{const o=this.#c.get(r);if(void 0===o)return 0;const s=t[o],a=e[o];return s&&a?s-((n||i())-a):1/0},this.#T=r=>{const o=e[r],s=t[r];return!!s&&!!o&&(n||i())-o>s}}#R=()=>{};#O=()=>{};#P=()=>{};#T=()=>!1;#L(){const t=new p(this.#e);this.#l=0,this.#b=t,this.#k=e=>{this.#l-=t[e],t[e]=0},this.#G=(t,e,n,i)=>{if(this.#x(e))return 0;if(!u(n)){if(!i)throw new TypeError("invalid size value (must be positive integer). When maxSize or maxEntrySize is used, sizeCalculation or size must be set.");if("function"!=typeof i)throw new TypeError("sizeCalculation must be a function");if(n=i(e,t),!u(n))throw new TypeError("sizeCalculation return invalid (expect positive integer)")}return n},this.#F=(e,n,i)=>{if(t[e]=n,this.#n){const n=this.#n-t[e];for(;this.#l>n;)this.#H(!0)}this.#l+=t[e],i&&(i.entrySize=n,i.totalCalculatedSize=this.#l)}}#k=t=>{};#F=(t,e,n)=>{};#G=(t,e,n,i)=>{if(n||i)throw new TypeError("cannot set size without setting maxSize or maxEntrySize on cache");return 0};*#_({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#f;this.#B(e)&&(!t&&this.#T(e)||(yield e),e!==this.#m);)e=this.#p[e]}*#I({allowStale:t=this.allowStale}={}){if(this.#a)for(let e=this.#m;this.#B(e)&&(!t&&this.#T(e)||(yield e),e!==this.#f);)e=this.#d[e]}#B(t){return void 0!==t&&this.#c.get(this.#h[t])===t}*entries(){for(const t of this.#_())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*rentries(){for(const t of this.#I())void 0===this.#u[t]||void 0===this.#h[t]||this.#x(this.#u[t])||(yield[this.#h[t],this.#u[t]])}*keys(){for(const t of this.#_()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*rkeys(){for(const t of this.#I()){const e=this.#h[t];void 0===e||this.#x(this.#u[t])||(yield e)}}*values(){for(const t of this.#_())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}*rvalues(){for(const t of this.#I())void 0===this.#u[t]||this.#x(this.#u[t])||(yield this.#u[t])}[Symbol.iterator](){return this.entries()}[Symbol.toStringTag]="LRUCache";find(t,e={}){for(const n of this.#_()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;if(void 0!==r&&t(r,this.#h[n],this))return this.get(this.#h[n],e)}}forEach(t,e=this){for(const n of this.#_()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;void 0!==r&&t.call(e,r,this.#h[n],this)}}rforEach(t,e=this){for(const n of this.#I()){const i=this.#u[n],r=this.#x(i)?i.__staleWhileFetching:i;void 0!==r&&t.call(e,r,this.#h[n],this)}}purgeStale(){let t=!1;for(const e of this.#I({allowStale:!0}))this.#T(e)&&(this.#$(this.#h[e],"expire"),t=!0);return t}info(t){const e=this.#c.get(t);if(void 0===e)return;const n=this.#u[e],i=this.#x(n)?n.__staleWhileFetching:n;if(void 0===i)return;const r={value:i};if(this.#w&&this.#v){const t=this.#w[e],n=this.#v[e];if(t&&n){const e=t-(o.now()-n);r.ttl=e,r.start=Date.now()}}return this.#b&&(r.size=this.#b[e]),r}dump(){const t=[];for(const e of this.#_({allowStale:!0})){const n=this.#h[e],i=this.#u[e],r=this.#x(i)?i.__staleWhileFetching:i;if(void 0===r||void 0===n)continue;const s={value:r};if(this.#w&&this.#v){s.ttl=this.#w[e];const t=o.now()-this.#v[e];s.start=Math.floor(Date.now()-t)}this.#b&&(s.size=this.#b[e]),t.unshift([n,s])}return t}load(t){this.clear();for(const[e,n]of t){if(n.start){const t=Date.now()-n.start;n.start=o.now()-t}this.set(e,n.value,n)}}set(t,e,n={}){if(void 0===e)return this.delete(t),this;const{ttl:i=this.ttl,start:r,noDisposeOnSet:o=this.noDisposeOnSet,sizeCalculation:s=this.sizeCalculation,status:a}=n;let{noUpdateTTL:l=this.noUpdateTTL}=n;const c=this.#G(t,e,n.size||0,s);if(this.maxEntrySize&&c>this.maxEntrySize)return a&&(a.set="miss",a.maxEntrySizeExceeded=!0),this.#$(t,"set"),this;let h=0===this.#a?void 0:this.#c.get(t);if(void 0===h)h=0===this.#a?this.#f:0!==this.#g.length?this.#g.pop():this.#a===this.#e?this.#H(!1):this.#a,this.#h[h]=t,this.#u[h]=e,this.#c.set(t,h),this.#d[this.#f]=h,this.#p[h]=this.#f,this.#f=h,this.#a++,this.#F(h,c,a),a&&(a.set="add"),l=!1;else{this.#M(h);const n=this.#u[h];if(e!==n){if(this.#A&&this.#x(n)){n.__abortController.abort(new Error("replaced"));const{__staleWhileFetching:e}=n;void 0===e||o||(this.#C&&this.#i?.(e,t,"set"),this.#S&&this.#y?.push([e,t,"set"]))}else o||(this.#C&&this.#i?.(n,t,"set"),this.#S&&this.#y?.push([n,t,"set"]));if(this.#k(h),this.#F(h,c,a),this.#u[h]=e,a){a.set="replace";const t=n&&this.#x(n)?n.__staleWhileFetching:n;void 0!==t&&(a.oldValue=t)}}else a&&(a.set="update")}if(0===i||this.#w||this.#N(),this.#w&&(l||this.#P(h,i,r),a&&this.#O(a,h)),!o&&this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}return this}pop(){try{for(;this.#a;){const t=this.#u[this.#m];if(this.#H(!0),this.#x(t)){if(t.__staleWhileFetching)return t.__staleWhileFetching}else if(void 0!==t)return t}}finally{if(this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}}}#H(t){const e=this.#m,n=this.#h[e],i=this.#u[e];return this.#A&&this.#x(i)?i.__abortController.abort(new Error("evicted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(i,n,"evict"),this.#S&&this.#y?.push([i,n,"evict"])),this.#k(e),t&&(this.#h[e]=void 0,this.#u[e]=void 0,this.#g.push(e)),1===this.#a?(this.#m=this.#f=0,this.#g.length=0):this.#m=this.#d[e],this.#c.delete(n),this.#a--,e}has(t,e={}){const{updateAgeOnHas:n=this.updateAgeOnHas,status:i}=e,r=this.#c.get(t);if(void 0!==r){const t=this.#u[r];if(this.#x(t)&&void 0===t.__staleWhileFetching)return!1;if(!this.#T(r))return n&&this.#R(r),i&&(i.has="hit",this.#O(i,r)),!0;i&&(i.has="stale",this.#O(i,r))}else i&&(i.has="miss");return!1}peek(t,e={}){const{allowStale:n=this.allowStale}=e,i=this.#c.get(t);if(void 0===i||!n&&this.#T(i))return;const r=this.#u[i];return this.#x(r)?r.__staleWhileFetching:r}#E(t,e,n,i){const r=void 0===e?void 0:this.#u[e];if(this.#x(r))return r;const o=new c,{signal:s}=n;s?.addEventListener("abort",(()=>o.abort(s.reason)),{signal:o.signal});const a={signal:o.signal,options:n,context:i},l=(i,r=!1)=>{const{aborted:s}=o.signal,l=n.ignoreFetchAbort&&void 0!==i;if(n.status&&(s&&!r?(n.status.fetchAborted=!0,n.status.fetchError=o.signal.reason,l&&(n.status.fetchAbortIgnored=!0)):n.status.fetchResolved=!0),s&&!l&&!r)return h(o.signal.reason);const c=u;return this.#u[e]===u&&(void 0===i?c.__staleWhileFetching?this.#u[e]=c.__staleWhileFetching:this.#$(t,"fetch"):(n.status&&(n.status.fetchUpdated=!0),this.set(t,i,a.options))),i},h=i=>{const{aborted:r}=o.signal,s=r&&n.allowStaleOnFetchAbort,a=s||n.allowStaleOnFetchRejection,l=a||n.noDeleteOnFetchRejection,c=u;if(this.#u[e]===u&&(l&&void 0!==c.__staleWhileFetching?s||(this.#u[e]=c.__staleWhileFetching):this.#$(t,"fetch")),a)return n.status&&void 0!==c.__staleWhileFetching&&(n.status.returnedStale=!0),c.__staleWhileFetching;if(c.__returned===c)throw i};n.status&&(n.status.fetchDispatched=!0);const u=new Promise(((e,i)=>{const s=this.#o?.(t,r,a);s&&s instanceof Promise&&s.then((t=>e(void 0===t?void 0:t)),i),o.signal.addEventListener("abort",(()=>{n.ignoreFetchAbort&&!n.allowStaleOnFetchAbort||(e(void 0),n.allowStaleOnFetchAbort&&(e=t=>l(t,!0)))}))})).then(l,(t=>(n.status&&(n.status.fetchRejected=!0,n.status.fetchError=t),h(t)))),d=Object.assign(u,{__abortController:o,__staleWhileFetching:r,__returned:void 0});return void 0===e?(this.set(t,d,{...a.options,status:void 0}),e=this.#c.get(t)):this.#u[e]=d,d}#x(t){if(!this.#A)return!1;const e=t;return!!e&&e instanceof Promise&&e.hasOwnProperty("__staleWhileFetching")&&e.__abortController instanceof c}async fetch(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:r=this.noDeleteOnStaleGet,ttl:o=this.ttl,noDisposeOnSet:s=this.noDisposeOnSet,size:a=0,sizeCalculation:l=this.sizeCalculation,noUpdateTTL:c=this.noUpdateTTL,noDeleteOnFetchRejection:h=this.noDeleteOnFetchRejection,allowStaleOnFetchRejection:u=this.allowStaleOnFetchRejection,ignoreFetchAbort:d=this.ignoreFetchAbort,allowStaleOnFetchAbort:p=this.allowStaleOnFetchAbort,context:m,forceRefresh:f=!1,status:g,signal:y}=e;if(!this.#A)return g&&(g.fetch="get"),this.get(t,{allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:r,status:g});const b={allowStale:n,updateAgeOnGet:i,noDeleteOnStaleGet:r,ttl:o,noDisposeOnSet:s,size:a,sizeCalculation:l,noUpdateTTL:c,noDeleteOnFetchRejection:h,allowStaleOnFetchRejection:u,allowStaleOnFetchAbort:p,ignoreFetchAbort:d,status:g,signal:y};let v=this.#c.get(t);if(void 0===v){g&&(g.fetch="miss");const e=this.#E(t,v,b,m);return e.__returned=e}{const e=this.#u[v];if(this.#x(e)){const t=n&&void 0!==e.__staleWhileFetching;return g&&(g.fetch="inflight",t&&(g.returnedStale=!0)),t?e.__staleWhileFetching:e.__returned=e}const r=this.#T(v);if(!f&&!r)return g&&(g.fetch="hit"),this.#M(v),i&&this.#R(v),g&&this.#O(g,v),e;const o=this.#E(t,v,b,m),s=void 0!==o.__staleWhileFetching&&n;return g&&(g.fetch=r?"stale":"refresh",s&&r&&(g.returnedStale=!0)),s?o.__staleWhileFetching:o.__returned=o}}async forceFetch(t,e={}){const n=await this.fetch(t,e);if(void 0===n)throw new Error("fetch() returned undefined");return n}memo(t,e={}){const n=this.#s;if(!n)throw new Error("no memoMethod provided to constructor");const{context:i,forceRefresh:r,...o}=e,s=this.get(t,o);if(!r&&void 0!==s)return s;const a=n(t,s,{options:o,context:i});return this.set(t,a,o),a}get(t,e={}){const{allowStale:n=this.allowStale,updateAgeOnGet:i=this.updateAgeOnGet,noDeleteOnStaleGet:r=this.noDeleteOnStaleGet,status:o}=e,s=this.#c.get(t);if(void 0!==s){const e=this.#u[s],a=this.#x(e);return o&&this.#O(o,s),this.#T(s)?(o&&(o.get="stale"),a?(o&&n&&void 0!==e.__staleWhileFetching&&(o.returnedStale=!0),n?e.__staleWhileFetching:void 0):(r||this.#$(t,"expire"),o&&n&&(o.returnedStale=!0),n?e:void 0)):(o&&(o.get="hit"),a?e.__staleWhileFetching:(this.#M(s),i&&this.#R(s),e))}o&&(o.get="miss")}#D(t,e){this.#p[e]=t,this.#d[t]=e}#M(t){t!==this.#f&&(t===this.#m?this.#m=this.#d[t]:this.#D(this.#p[t],this.#d[t]),this.#D(this.#f,t),this.#f=t)}delete(t){return this.#$(t,"delete")}#$(t,e){let n=!1;if(0!==this.#a){const i=this.#c.get(t);if(void 0!==i)if(n=!0,1===this.#a)this.#V(e);else{this.#k(i);const n=this.#u[i];if(this.#x(n)?n.__abortController.abort(new Error("deleted")):(this.#C||this.#S)&&(this.#C&&this.#i?.(n,t,e),this.#S&&this.#y?.push([n,t,e])),this.#c.delete(t),this.#h[i]=void 0,this.#u[i]=void 0,i===this.#f)this.#f=this.#p[i];else if(i===this.#m)this.#m=this.#d[i];else{const t=this.#p[i];this.#d[t]=this.#d[i];const e=this.#d[i];this.#p[e]=this.#p[i]}this.#a--,this.#g.push(i)}}if(this.#S&&this.#y?.length){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}return n}clear(){return this.#V("delete")}#V(t){for(const e of this.#I({allowStale:!0})){const n=this.#u[e];if(this.#x(n))n.__abortController.abort(new Error("deleted"));else{const i=this.#h[e];this.#C&&this.#i?.(n,i,t),this.#S&&this.#y?.push([n,i,t])}}if(this.#c.clear(),this.#u.fill(void 0),this.#h.fill(void 0),this.#w&&this.#v&&(this.#w.fill(0),this.#v.fill(0)),this.#b&&this.#b.fill(0),this.#m=0,this.#f=0,this.#g.length=0,this.#l=0,this.#a=0,this.#S&&this.#y){const t=this.#y;let e;for(;e=t?.shift();)this.#r?.(...e)}}}function g(t){window.$monomerHover=t}var y=n(2003),b=n(6077),v=n(3561),w=n(9235);const C="MonomerHoverLinks";async function A(t,e,n,i,o,s=!1){const a=i.getSeqHandler(t),l=a.alphabet==y.YI.RNA||a.alphabet==y.YI.DNA,c=a.isHelm()&&l,h=!a.isHelm()&&l,u=t=>null==t?null:c?s?t:Math.floor(t/3):h&&s?3*t+1:t,d=s?await i.getHelmToMolfileConverter(n):null,p=new f({max:100});function m(t,e){const a=t.get(e);if(null==a)return null;let l=p.get(a);return l||p.set(a,l=function(t,e){const a=i.getSeqHandler(t);if(s){const t=a.getHelm(e);return i.helmToAtomicLevelSingle(t,d,!1,!1).monomers}{const t=a.getSplitted(e),i=a.defaultBiotype,s=r().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:i}))).toArray(),l=a.alphabet,c=l==y.YI.RNA||l==y.YI.DNA?"RNA":"PEPTIDE",h=(0,b.eM)([s],c,l,n,o);return(0,v.gU)(s,h,l,c).monomers}}(t,e)),l}const A={targetCol:e,handler:(e,i,r)=>{const o=r.grid,s=e.tableRowIndex,a=e.gridRow,l=o.cell(r.name,a),c=null!==(h=window.$monomerHover)&&void 0!==h?h:null;var h;if(!c||c&&(c.dataFrameId!=t.dataFrame.id||c.gridRowIdx!=a||c.seqColName!=t.name||c.seqPosition!=i?.position)){if(c&&(g(null),c.gridCell.render()),!i)return g(null),!0;g({gridCell:l,dataFrameId:t.dataFrame.id,gridRowIdx:a,seqColName:t.name,seqPosition:u(i?.position)??-1,getSubstruct:()=>{if(!i||"*"===i.symbol)return;const e=m(t,s);if(!e)return;const r=e.get(u(i?.position));return r?(0,w.H)([r],n):{atoms:[],bonds:[],highlightAtomColors:[],highlightBondColors:[]}}}),l.render()}return!0},getSubstruct:i=>{if("true"!=e.getTag(".sequence-src-highlight-monomers"))return;if(null==i)return;if(!t.get(i))return;const r=m(t,i);return r?(0,w.H)(r.values(),n):void 0}};return function(t,e){let n=t[C];n||(n=t[C]=[]),n.push(e),t[C]=n}(t.temp,A),function(t,e){let n=t["substruct-providers"];n||(n=t["substruct-providers"]=[]),n.push(e),t["substruct-providers"]=n}(e.temp,A),A}function S(t,e){try{const n=t.tableColumn;if(!n)return;const i=function(t){return t.temp[C]??[]}(n);for(let n=i.length-1;n>=0;--n){const r=i[n],o=t.grid.col(r.targetCol.name);if(o&&!r.handler(t,e,o))break}}catch(t){console.error(t)}}},6718:(t,e,n)=>{"use strict";n.d(e,{A7:()=>p,pj:()=>h,uL:()=>u,uX:()=>c});var i=n(6082),r=n(4328),o=n(6295),s=n(3151),a=n(3077),l=n(439);function c(t){const e=[];for(let n=0;n<t.rowCount;n++){const i={};Object.keys(s.Ec).forEach((e=>{if("symbol"===e){const r=t.get(s.Ec[e],n);i[e]="."===r?t.get(s.yw,n):r}else if("rgroups"===e){const r=t.get(s.Ec[e],n).split("\n"),o=[];r.forEach((t=>{const e={},n=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===n?"H":"OH",e.label=`R${i}`,o.push(e)})),i[e]=o}else s.Ec[e]&&(i[e]=t.get(s.Ec[e],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),e.push(i)}return e}async function h(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e,n){t instanceof i.Column&&(t=(0,a.R)(t,n).columns.toList());const o=(await h()).getMonomerLib(),s=new Array(t.length),c=t[0].length,u=new Float32Array(c);for(let n=0;n<t.length;++n){const a=n<e.length?e.getCanonical(n):l._S,h=o.getMonomer("PEPTIDE",a)?.smiles??"",d=t[n],p=d.getRawData(),m=d.categories,f=m.indexOf("");if(s[n]={categories:m,data:p,emptyIndex:f},void 0===a)continue;const g=i.Column.fromStrings("smiles",m.map((t=>o.getMonomer("PEPTIDE",t)?.smiles??""))),y=(i.DataFrame.fromColumns([g]),await r.chem.getSimilarities(g,h)),b=y?y.getRawData():null;for(let t=0;t<c;++t){const e=p[t];a!==l._S&&e!==f?u[t]+=b[e]:a===l._S&&e===f&&(u[t]+=1)}}for(let n=0;n<u.length;++n){let r=u[n]/e.length;for(let o=0;o<t.length;++o){const t=s[o];if(o>=e.length&&t.data[n]!==t.emptyIndex||t.data[n]===t.emptyIndex&&o<e.length){r=i.FLOAT_NULL;break}}u[n]=r}return i.Column.fromFloat32Array("Similarity",u)}async function d(t){const e=(await h()).getMonomerLib(),n=[],o={},s=t.map((t=>e.getMonomer("PEPTIDE",t)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let e=0;e<s.length;++e){o[t[e]]=e;const i=s[e],l=""===i?new Array(s.length).fill(0):(await r.chem.getSimilarities(a,i)).getRawData();l[e]=1,n[e]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:o}}async function p(t,e="Morgan"){const n=(await h()).getMonomerLib(),r=new Array(t.length).fill(0).map((()=>new Array(t.length).fill(0))),s={},a=t.map((t=>n.getMonomer("PEPTIDE",t)?.molfile||n.getMonomer("PEPTIDE",t)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(t);const c=i.Column.fromStrings("smiles",a),u=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:e}))?.entries);if(!u)return console.warn(`${e} Fingerprints could not be calculated for monomers from chem package.\n      falling back to Morgan fingerprints`),await d(t);for(let e=0;e<u.length;++e)if(r[e][e]=1,s[t[e]]=e,u[e])for(let t=e+1;t<u.length;++t)u[t]&&(r[e][t]=r[t][e]=(0,o.$1)(u[e],u[t]));return{scoringMatrix:r,alphabetIndexes:s}}},6197:(t,e,n)=>{"use strict";n.d(e,{Y:()=>r});var i=n(3599);function r(t){let e;switch(t){case i.o.BASE:case i.o.SUGAR:case i.o.LINKER:case i.o.NUCLEOTIDE:case"nucleotide":e="RNA";break;case i.o.AA:e="PEPTIDE";break;case i.o.CHEM:e="CHEM";break;case i.o.BLOB:e="BLOB";break;default:e="PEPTIDE",console.warn(`Unexpected HelmType '${t}'`)}return e}},9235:(t,e,n)=>{"use strict";n.d(e,{H:()=>c,R:()=>l});var i=n(6082),r=n(1991),o=n.n(r),s=n(330),a=n(3599);async function l(t,e,r,l,c,h,u){const d=t.length,p=t.dataFrame,m=Math.max(navigator.hardwareConcurrency-2,1),f=new Array(m).fill(null).map((()=>new Worker(new URL(n.p+n.u(455),n.b)))),g=d/m,y=new Array(m),b=h.getSeqHandler(t),v="RNA"==l?a.o.NUCLEOTIDE:a.o.AA,w=o().count(0).take(t.length).map((t=>{const e=b.getSplitted(t);return o().count(0).take(e.length).map((t=>({position:t,symbol:e.getCanonical(t),biotype:v}))).toArray()})).toArray();for(let t=0;t<m;t++){const n=f[t],i=Math.floor(t*g),o=t===m-1?d:Math.floor((t+1)*g);y[t]=new Promise((t=>{n.onmessage=e=>{t(e.data)}})),n.postMessage({seqList:w,monomersDict:e,alphabet:r,polymerType:l,start:i,end:o})}const C=[],A=[];await Promise.all(y).then((t=>{for(const e of t)C.push(...e.molfiles),A.push(...e.warnings)})),setTimeout((()=>{f.forEach((t=>{t.terminate()}))}),0);const S=(0,s.qj)(p,t.name),x=i.Column.fromType(i.COLUMN_TYPE.STRING,S,t.length).init((t=>C[t]?.molfile));return x.semType=i.SEMTYPE.MOLECULE,x.meta.units=i.UNITS.Molecule.MOLBLOCK,x.setTag(".sequence-src-col",t.name),{molCol:x,warnings:A}}function c(t,e){const n={},r={};for(const o of t){const t=e.getWebEditorMonomer(o.biotype,o.symbol).backgroundcolor,a=(0,s.vG)(t??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const t of o.atoms)n[t]=a;for(const t of o.bonds)r[t]=a}return{atoms:Object.keys(n).map((t=>parseInt(t))),bonds:Object.keys(r).map((t=>parseInt(t))),highlightAtomColors:n,highlightBondColors:r}}},3561:(t,e,n)=>{"use strict";n.d(e,{Hb:()=>l,YN:()=>f,gU:()=>c});var i=n(8123),r=n(294),o=n(3151),s=n(439),a=n(6197);function l(t,e,n){const r=new Map;for(const a of t.getMonomerSymbolsByType(e)){const l=t.getMonomer(e,a);if("RNA"===e&&("Branch"===l.monomerType||n===s.YI.DNA&&l.symbol===i.u.DEOXYRIBOSE.symbol||n===s.YI.RNA&&l.symbol===i.u.RIBOSE.symbol||l.symbol===i.u.PHOSPHATE.symbol)||"PEPTIDE"===e&&"Branch"!==l.monomerType){const t={};o.f6.forEach((e=>{t[e]=l[e]})),r.set(l.symbol,t)}}return r}function c(t,e,n,o){if(0===t.length)return r.vF.createEmpty();const l=m,{atomCount:c,bondCount:u,needsCapping:p}=l(t,e,n,o),g=new Array(c),y=new Array(u);let b,v=null,w=null;"PEPTIDE"===o?b=h:(b=d,v=n===s.YI.DNA?(0,r.xb)(e,i.u.DEOXYRIBOSE):(0,r.xb)(e,i.u.RIBOSE),w=(0,r.xb)(e,i.u.PHOSPHATE));const C={i:0,nodeShift:0,bondShift:0,backbonePositionShift:new Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},A={sugar:v,phosphate:w,seqLength:t.length,atomCount:c,bondCount:u},S=new r.Cg,x=[];let E=0;for(C.i=0;C.i<A.seqLength;++C.i){const n=t[C.i];if(n.symbol===s._S)continue;const i=(0,r.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),o=C.nodeShift,l=C.bondShift;b(i,g,y,C,A),i.stereoAtoms?.forEach((t=>x.push(t+E))),E+=i.atoms.x.length;const c=C.nodeShift-o,h=new Array(c);for(let t=0;t<c;++t)h[t]=o+t;const u=C.bondShift-l,d=new Array(u);for(let t=0;t<u;++t)d[t]=l+t;S.set(C.i,{biotype:n.biotype,symbol:n.symbol,atoms:h,bonds:d})}p&&function(t,e,n,r){const o=n.nodeShift+1;t[r.atomCount]=i.u.V3K_BEGIN_DATA_LINE+o+" "+i.u.OXYGEN+" "+f(n.backbonePositionShift[0])+" "+n.flipFactor*f(n.backbonePositionShift[1])+" 0.000000 0\n";const s=n.backboneAttachNode,a=o;e[r.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+s+" "+a+"\n"}(g,y,C,A);const M=i.u.V3K_BEGIN_COUNTS_LINE+c+" "+u+i.u.V3K_COUNTS_LINE_ENDING;let _="";return _+=i.u.V3K_HEADER_FIRST_LINE,_+=i.u.V3K_HEADER_SECOND_LINE,_+=i.u.V3K_BEGIN_CTAB_BLOCK,_+=M,_+=i.u.V3K_BEGIN_ATOM_BLOCK,_+=g.join(""),_+=i.u.V3K_END_ATOM_BLOCK,_+=i.u.V3K_BEGIN_BOND_BLOCK,_+=y.join(""),_+=i.u.V3K_END_BOND_BLOCK,x.length>0&&(_+=function(t){const e=[];let n=`M  V30 MDLV30/STEABS ATOMS=(${t.length}`;for(let i=0;i<t.length;i++){const r=`${n} ${t[i]}`;r.length>76?(e.push(`${n} -\n`),n=`M  V30 ${t[i]}`):n=r,i===t.length-1&&e.push(`${n})\n`)}return`M  V30 BEGIN COLLECTION\n${e.join("")}M  V30 END COLLECTION\n`}(x)),_+=i.u.V3K_END_CTAB_BLOCK,_+=i.u.V3K_END,{molfile:_,monomers:S}}function h(t,e,n,i){i.flipFactor=(-1)**(i.i%2),u(t,e,n,i)}function u(t,e,n,r){!function(t,e,n){for(let r=0;r<t.atoms.atomTypes.length;++r){const o=n.nodeShift+r+1;e[n.nodeShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.atoms.atomTypes[r]+" "+f(n.backbonePositionShift[0]+t.atoms.x[r])+" "+f(n.backbonePositionShift[1]+n.flipFactor*t.atoms.y[r])+" "+t.atoms.kwargs[r]}}(t,e,r),p(t,n,r),function(t,e,n){if(0!==n.backboneAttachNode){const r=n.bondShift,o=n.backboneAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[n.bondShift-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+o+" "+s+"\n"}}(t,n,r),null!==t.meta.branchShift&&t.meta.terminalNodes.length>2&&function(t,e){e.branchAttachNode=e.nodeShift+t.meta.terminalNodes[2];for(let n=0;n<2;++n)e.branchPositionShift[n]=e.backbonePositionShift[n]+t.meta.branchShift[n]}(t,r),function(t,e){e.backboneAttachNode=e.nodeShift+t.meta.terminalNodes[1],e.bondShift+=t.bonds.atomPairs.length+1,e.nodeShift+=t.atoms.atomTypes.length,e.backbonePositionShift[0]+=t.meta.backboneShift?.[0]??0,e.backbonePositionShift[1]+=e.flipFactor*(t.meta.backboneShift?.[1]??0)}(t,r)}function d(t,e,n,r,o){if(0===r.i)u(o.sugar,e,n,r);else for(const t of[o.phosphate,o.sugar])u(t,e,n,r);!function(t,e,n,r){(function(t,e,n){for(let r=0;r<t.atoms.atomTypes.length;++r){const o=n.nodeShift+r+1;e[n.nodeShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.atoms.atomTypes[r]+" "+f(n.branchPositionShift[0]+t.atoms.x[r])+" "+f(n.branchPositionShift[1]+n.flipFactor*t.atoms.y[r])+" "+t.atoms.kwargs[r]}})(t,e,r),p(t,n,r),function(t,e,n){const r=n.bondShift,o=n.branchAttachNode,s=t.meta.terminalNodes[0]+n.nodeShift;e[r-1]=i.u.V3K_BEGIN_DATA_LINE+r+" 1 "+o+" "+s+"\n"}(t,n,r);const o=r.bondShift,s=r.branchAttachNode,a=t.meta.terminalNodes[0]+r.nodeShift;n[o-1]=i.u.V3K_BEGIN_DATA_LINE+o+" 1 "+s+" "+a+"\n",r.bondShift+=t.bonds.atomPairs.length+1,r.nodeShift+=t.atoms.atomTypes.length}(t,e,n,r)}function p(t,e,n){for(let r=0;r<t.bonds.atomPairs.length;++r){const o=n.bondShift+r+1,s=t.bonds.atomPairs[r][0]+n.nodeShift,a=t.bonds.atomPairs[r][1]+n.nodeShift;let l="";if(t.bonds.bondConfiguration.has(r)){let e=t.bonds.bondConfiguration.get(r);n.flipFactor<0&&(e=1===e?3:1),l=" CFG="+e}const c=t.bonds.kwargs.has(r)?" "+t.bonds.kwargs.get(r):"";e[n.bondShift+r]=i.u.V3K_BEGIN_DATA_LINE+o+" "+t.bonds.bondTypes[r]+" "+s+" "+a+l+c+"\n"}}function m(t,e,n,o){let l=0,c=0,h=0,u=!0,d=null;for(const n of t)if(n.symbol!==s._S){if("*"==n.symbol)throw new Error("Gap canonical symbol is '', not '*");d=(0,r.xb)(e,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),l+=d.atoms.x.length,c+=d.bonds.bondTypes.length,h++}if("PEPTIDE"===o)l+=1,c+=h,h>0&&(d?.meta?.rNodes?.length??0)<2&&(u=!1,l-=1,c-=1);else{const o=n===s.YI.DNA?(0,r.xb)(e,i.u.DEOXYRIBOSE):(0,r.xb)(e,i.u.RIBOSE),a=(0,r.xb)(e,i.u.PHOSPHATE);l+=(t.length-1)*a.atoms.x.length,l+=t.length*o.atoms.x.length,l+=1,c+=(t.length-1)*a.bonds.bondTypes.length,c+=t.length*o.bonds.bondTypes.length,c-=1,c+=3*t.length}return{atomCount:l,bondCount:c,needsCapping:u}}function f(t){return Math.round(i.u.PRECISION_FACTOR*t)/i.u.PRECISION_FACTOR}},6077:(t,e,n)=>{"use strict";n.d(e,{C4:()=>m,eM:()=>f});var i=n(4328),r=n(6082),o=n(1991),s=n.n(o),a=n(439),l=n(3561),c=n(9235),h=n(294),u=n(9192),d=n(330),p=n(8123);async function m(t,e,n,o,l){if(e.semType!==r.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let h=e;const p=o.getSeqHandler(e);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=e.name);try{g=o.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(t){const[e,n]=(0,u.AP)(t);return{molCol:null,warnings:[e]}}const y=function(t,e){const n=t.length,r=new Array(n),o=e.getSeqHandler(t);let a=!1;const l=o.defaultBiotype;for(let t=0;t<n;++t){const e=o.getSplitted(t);a||(a=0===e.length),r[t]=s().count(0).take(e.length).filter((t=>!e.isGap(t))).map((t=>({position:t,biotype:l,symbol:e.getCanonical(t)}))).toArray()}return a&&i.shell.warning(`Some values in the "${t.name}" column are empty`),r}(h,o),b=f(y,m,g,n,l),v=h.length,w=await(0,c.R)(h,b,g,m,n,o,l);return w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`),w}function f(t,e,n,i,r){const o=(0,l.Hb)(i,e,n),s={},c={value:null};if("RNA"===e){const t=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of t)g(s,n.symbol,o,r,e,c)}for(let n=0;n<t.length;++n){const i=t[n];for(const t of i){const n=t.symbol;if(""!==n)try{if("RNA"===e&&3===n.split(/\(|\)/).filter((t=>!!t)).length){const t=n.split(/\(|\)/)[1];g(s,t,o,r,e,c),s[e]?.[t]&&(s[e][n]=s[e][t])}else g(s,n,o,r,e,c)}catch(t){const e=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${e}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${e}`)}}}return s}function g(t,e,n,i,r,o){const s={polymerType:r,symbol:e};if(!(0,h.bq)(t,s)){const a=function(t,e,n,i,r){if(e.has(t)){const s=e.get(t),a=function(t){const e=[];for(const n of t){let t=n.capGroupSmiles;t||(t=n.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,"").replace("OH","O").replace("Oh","O"),e.push(t)}return e}(s.rgroups),c=(o=s.molfile).includes("V3000")?function(t){const e=new Map,n=/M  V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(t));)i.index===n.lastIndex&&n.lastIndex++,e.set(parseInt(i[1]),parseInt(i[3]));return e}(o):function(t){const e=new Map;let n=t.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=t.indexOf("\n",n);const r=parseInt(t.substring(n,i).replace(/^A\s+/,""));n=t.indexOf("R",i),i=t.indexOf("\n",n);const o=parseInt(t.substring(n,i).replace(/^R/,""));e.set(r,o),n=t.indexOf(p.u.V2K_A_LINE,i)}for(n=t.indexOf(p.u.V2K_RGP_LINE,0),i=t.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=t.indexOf("\n",n);const r=t.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<r.length;t+=2){if(e.has(r[t])&&e.get(r[t])!==r[t+1])throw new Error(`r-group index ${r[t]} has already been added with a different value`);e.set(r[t],r[t+1])}n=t.indexOf(p.u.V2K_RGP_LINE,i)}return e}(o),h=s.molfile.includes("V3000")?s.molfile:function(t,e){const n=e.get_mol(function(t){return t.split("\n").map((t=>{const e=t.indexOf(" R#  "),n=t.indexOf(" R   ");if(-1===e&&-1===n)return t;const i=-1!==e?e:n,r=t.split("");for(let t=i+5;t<r.length;t++)" "!==r[t]&&(r[t]="0");return r.join("")})).join("\n")}(t)),i=n.get_v3Kmolblock();return n.delete(),i}(function(t){let e=t.indexOf(p.u.V2K_A_LINE,0);-1===e&&(e=t.indexOf(p.u.V2K_RGP_LINE));const n=t.indexOf(p.u.V3K_END,e);return t.substring(0,e)+t.substring(n)}(s.molfile),n),u=function(t){let e=(t=t.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,n));return e=n+1,n=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,n))}}(h),d=function(t,e){const n=new Array(e),i=new Float32Array(e),r=new Float32Array(e),o=new Array(e);let s=t.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;l++){s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,s)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s),s=a+1,a=t.indexOf(" ",s),n[l]=t.substring(s,a);const e=new Array(2);for(let n=0;n<2;++n)s=a+1,a=t.indexOf(" ",s),e[n]=parseFloat(t.substring(s,a));i[l]=e[0],r[l]=e[1],s=a,a=t.indexOf("\n",s)+1,o[l]=t.slice(s,a),s=a}return{atomTypes:n,x:i,y:r,kwargs:o}}(h,u.atomCount),m=function(t,e){const n=new Uint32Array(e),i=new Array(e),r=new Map,o=new Map;let s=t.indexOf(p.u.V3K_BEGIN_BOND_BLOCK);s=t.indexOf("\n",s);let a=s;for(let l=0;l<e;++l){const e=new Array(3);s=t.indexOf(p.u.V3K_BEGIN_DATA_LINE,a)+p.u.V3K_IDX_SHIFT,a=t.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(t.indexOf("\n",s),t.indexOf(" ",s)),e[n]=parseInt(t.slice(s,a));n[l]=e[0],i[l]=e.slice(1);const c=t.indexOf("\n",s);let h=t.slice(a,c),u=h.indexOf(p.u.V3K_BOND_CONFIG);if(-1!==u){u=h.indexOf("=",u)+1;let t=h.indexOf(" ",u);-1===t&&(t=h.length);const e=parseInt(h.slice(u,t));r.set(l,e);const n=p.u.V3K_BOND_CONFIG+e.toString();h=h.replace(n,"")}h||o.set(l,h)}return{bondTypes:n,atomPairs:i,bondConfiguration:r,kwargs:o}}(h,u.bondCount),f=function(t,e,n,i){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(t,e,n){for(const[i,r]of n)t.atomTypes[i-1]=e[r-1]}(t,n,i),function(t,e){e.rNodes=Array.from(t.keys());for(let n=0;n<e.rNodes.length;n++)for(const i of[1,2])if(t.get(e.rNodes[n])===i){const t=e.rNodes[i-1];e.rNodes[i-1]=e.rNodes[n],e.rNodes[n]=t}}(i,r),y(e,r),r}(d,m,a,c),g=function(t){let e=[],n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=t.indexOf(")",n);e=e.concat(t.substring(n,i).split(" ").slice(1).map((t=>parseInt(t)))),n=i,n=t.indexOf("M  V30 MDLV30/STEABS ATOMS=(",n)}return e}(h),v={atoms:d,bonds:m,meta:f,stereoAtoms:g};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,r=t.atoms.y;M(t,-i[e],-r[e]);const o=A(i[n],r[n]);S(t.atoms,-o),i[t.meta.rNodes[1]-1]<0&&x(t);const s=function(t){const e=function(t){const e=new Map;for(const n of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=n[t],r=n[(t+1)%2];e.has(i)?e.get(i)?.push(r):e.set(i,new Array(1).fill(r))}return e}(t);let n=0;const i=t.atoms.atomTypes.length;let r=0;if(t.meta.terminalNodes.length<2)return null;for(;0===n;){const o=e.get(t.meta.terminalNodes[1])[r];if(t.atoms.atomTypes[o-1]===p.u.OXYGEN&&o!==t.meta.rNodes[1]&&(n=o),r++,r>i)return null}return n}(t);null!=s&&(function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){E(t,!0)}(t),S(t.atoms,-function(t,e){return A(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,s),function(t,e){const n=t.atoms.x;n[t.meta.rNodes[1]-1]>n[e-1]&&function(t,e,n){const i=e-1,r=n-1,o=t.atoms.x,s=t.atoms.y,a=o[i],l=s[i];o[i]=o[r],s[i]=s[r],o[r]=a,s[r]=l}(t,e,t.meta.rNodes[1])}(t,s))}(v):t===p.u.RIBOSE.symbol||t===p.u.DEOXYRIBOSE.symbol?function(t,e){const n=t.atoms.x,i=t.atoms.y;let r=t.meta.terminalNodes[0]-1;const o=t.meta.rNodes[1]-1;M(t,-n[r],-i[r]);const s=A(n[t.meta.rNodes[2]-1],i[t.meta.rNodes[2]-1]);S(t.atoms,-s),n[t.meta.rNodes[0]-1]>n[t.meta.rNodes[1]-1]&&x(t);const a=A(n[o],i[o]);S(t.atoms,3*Math.PI/2-a),e.value=function(t){const e=t.atoms.x,n=t.atoms.y,i=t.meta.rNodes[2]-1,r=t.meta.terminalNodes[2]-1,o=e[i]-e[r],s=n[i]-n[r];return Math.atan2(o,s)}(t),r=t.meta.terminalNodes[0]-1,M(t,-n[r],-i[r])}(v,r):t===p.u.PHOSPHATE.symbol?function(t){const e=t.meta.rNodes[1]-1,n=t.meta.rNodes[0]-1,i=t.atoms.x,r=t.atoms.y;M(t,-i[e],-r[e]);const o=A(i[n],r[n]);S(t.atoms,Math.PI/2-o)}(v):function(t,e){const n=t.atoms.x,i=t.atoms.y,r=t.meta.terminalNodes[0]-1,o=t.meta.rNodes[0]-1;M(t,-n[r],-i[r]);const s=A(n[o],i[o]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(t.atoms,Math.PI-s+a);const c=function(t,e){return(0,l.YN)(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:n[t.meta.rNodes[0]-1],y:i[t.meta.rNodes[0]-1]},{x:n[t.meta.terminalNodes[0]-1],y:i[t.meta.terminalNodes[0]-1]});if(1!=c)for(let t=0;t<n.length;++t)n[t]=(0,l.YN)(n[t]/c),i[t]=(0,l.YN)(i[t]/c)}(v,r),function(t,e,n){"PEPTIDE"===t?(b(e,t),w(e,e.meta.rNodes[1])):n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],y(e.bonds,e.meta),b(e,t),w(e,e.meta.rNodes[1]),w(e,e.meta.rNodes[0]),w(e,e.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],M(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),b(e,t),w(e,e.meta.rNodes[1]))}(i,v,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===p.u.HYDROGEN&&(w(t,e+1),--e),++e}(v),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)"oh"===t.atoms.atomTypes[e]?.toLowerCase()&&(t.atoms.atomTypes[e]="O"),"?"===t.atoms.atomTypes[e]&&(t.atoms.atomTypes[e]="H"),++e}(v),function(t){const e=" RGROUPS=(1 1)";for(let n=0;n<(t.atoms.kwargs?.length??0);n++){const i=t.atoms.kwargs[n];i&&i.includes(e)&&(t.atoms.kwargs[n]=i.replace(e,""))}}(v),v}var o;return null}(e,n,i,r,o);if(!a)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);(0,h.LQ)(t,s,a)}}function y(t,e){const n=e.rNodes;e.terminalNodes=new Array(n.length).fill(0);const i=e.terminalNodes,r=t.atomPairs;let o=0,s=0;for(;o<r.length&&s<i.length;){for(let t=0;t<i.length;++t)for(let e=0;e<2;++e)r[o][e]===n[t]&&(i[t]=r[o][(e+1)%2],n.length,++s);++o}}function b(t,e){t.meta.rNodes.length>1&&(t.meta.backboneShift=v(t,t.meta.rNodes[1]-1,t.meta.terminalNodes[0]-1)),"RNA"===e&&t.meta.rNodes.length>2&&(t.meta.branchShift=v(t,t.meta.rNodes[2]-1,t.meta.terminalNodes[0]-1))}function v(t,e,n){return[(0,l.YN)(t.atoms.x[e]-t.atoms.x[n]),(0,l.YN)(t.atoms.y[e]-t.atoms.y[n])]}function w(t,e){if(void 0!==e){const n=e-1,i=t.atoms,r=t.bonds,o=t.meta;i.atomTypes.splice(n,1),i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let t=0;t<o.terminalNodes.length;++t)o.terminalNodes[t]>e?--o.terminalNodes[t]:o.terminalNodes[t]===e&&(o.terminalNodes[t]=-1);for(let t=0;t<o.rNodes.length;++t)o.rNodes[t]>e?--o.rNodes[t]:o.rNodes[t]===e&&(o.rNodes[t]=-1);let s=0;for(;s<r.atomPairs.length;){const t=r.atomPairs[s][0],n=r.atomPairs[s][1];t===e||n===e?(r.atomPairs.splice(s,1),r.bondTypes=C(Uint32Array,r.bondTypes,s,1),r.bondConfiguration.has(s)&&r.bondConfiguration.delete(s),r.kwargs.has(s)&&r.kwargs.delete(s),--s):(r.atomPairs[s][0]=t>e?t-1:t,r.atomPairs[s][1]=n>e?n-1:n),++s}let a=Array.from(r.bondConfiguration.keys());a.forEach((t=>{if(r.bondConfiguration.has(t)&&t>n){const e=r.bondConfiguration.get(t);r.bondConfiguration.delete(t),r.bondConfiguration.set(t-1,e)}})),a=Array.from(r.kwargs.keys()),a.forEach((t=>{if(r.kwargs.has(t)&&t>n){const e=r.kwargs.get(t);r.kwargs.delete(t),r.kwargs.set(t-1,e)}}))}}function C(t,e,n,i){const r=new t(e.length-i);let o=0,s=0;for(;o<e.length;)o===n&&(o+=i),r[s]=e[o],++s,++o;return r}function A(t,e){let n;if(0===t)n=e>0?0:Math.PI;else if(0===e)n=t>0?-Math.PI/2:Math.PI/2;else{const i=e/t,r=Math.atan(i);n=t<0?Math.PI/2+r:-Math.PI/2+r}return n}function S(t,e){if(0!==e){const n=t.x,i=t.y,r=Math.cos(e),o=Math.sin(e);for(let t=0;t<n.length;++t){const e=n[t];n[t]=(0,l.YN)(e*r-i[t]*o),i[t]=(0,l.YN)(e*o+i[t]*r)}}}function x(t){E(t,!1)}function E(t,e){if(e){const e=t.atoms.y;for(let t=0;t<e.length;t++)e[t]=-e[t]}else{const e=t.atoms.x;for(let t=0;t<e.length;t++)e[t]=-e[t]}const n=t.bonds.bondConfiguration;for(const[t,e]of n){const i=1===e?3:1;n.set(t,i)}}function M(t,e,n){const i=t.atoms.x,r=t.atoms.y;for(let t=0;t<i.length;++t)i[t]=(0,l.YN)(i[t]+e),void 0!==n&&(r[t]=(0,l.YN)(r[t]+n))}},294:(t,e,n)=>{"use strict";function i(t,e){return t[e.polymerType]?.[e.symbol]}function r(t,e){return!!t[e.polymerType]?.[e.symbol]}function o(t,e,n){let i=t[e.polymerType];i||(i=t[e.polymerType]={}),i[e.symbol]=n}n.d(e,{Cg:()=>s,LQ:()=>o,bq:()=>r,vF:()=>a,xb:()=>i});class s extends Map{constructor(t){super(t)}}class a{constructor(t,e){this.molfile=t,this.monomers=e}static createEmpty(){return new a("",new s(null))}}},330:(t,e,n)=>{"use strict";n.d(e,{kA:()=>r,pz:()=>s,qj:()=>o,vG:()=>a});var i=n(2003);function r(t,e){return t?t.columns.getUnusedName(e):e}function o(t,e){return r(t,`molfile(${e})`)}function s(t){let e;if(t===i.YI.PT||t===i.YI.UN)e="PEPTIDE";else{if(t!==i.YI.RNA&&t!==i.YI.DNA)throw new Error(`Unexpected alphabet '${t}'.`);e="RNA"}return e}function a(t){const e=7===t.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(t);return e?[parseInt(e[1],16)/256,parseInt(e[2],16)/256,parseInt(e[3],16)/256,e.length>4?parseInt(e[4],16)/256:.3]:null}},1093:(t,e,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(t,e,n)=>{"use strict";n.d(e,{e:()=>i});class i{static makePalette(t,e=!1,n=i){const r={};return t.forEach((t=>{const n=t[0],i=t[1];n.forEach(((t,n)=>{r[t]=this.colourPalette[i][e?0:n]}))})),new n(r)}constructor(t){this._palette=t}get(t,e){return this._palette[t]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(t,e,n)=>{"use strict";n.d(e,{O:()=>o,n:()=>r});var i=n(1858);class r{constructor(t,e=!0,n){return this.substructure=t,this.readOnly=e,this.logger=n,new Proxy(this,{set:(t,e,n)=>{if(this.logger?.debug(`BioFilterProps.set ${e.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return t[e]=n,!0}})}}class o{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(t){this._propsChanging=!0;try{this._props=t,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const t={};for(const[e,n]of Object.entries(this.props))"_onChanged"!==e&&"logger"!==e&&(t[e]=this.props[e]);return t}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(t,e,n)=>{"use strict";var i=n(6082),r=n(7362),o=n(6718);function s(t,e=!0){if(null==t)return"rgb(100,100,100)";const n=i.Color.fromHtml(t);if(e){const t=i.Color.g(n),e=i.Color.r(n),r=i.Color.b(n),o=Math.sqrt(Math.pow(0-e,2)+Math.pow(0-t,2)+Math.pow(0-r,2));if(o>210)return`rgb(${e/o*210},${t/o*210},${r/o*210})`}return i.Color.toRgb(n)}class a{static hashCode(t){let e=0;if(0===t.length)return e;for(let n=0;n<t.length;n++)e=(e<<5)-e+t.charCodeAt(n),e|=0;return e}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,o.pj)().then((t=>{t.awaitLoaded(1/0).then((()=>{const e=t.getMonomerLib();e.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=e.getPolymerTypes();for(const t of this.polymerTypes){const n=e.getMonomerSymbolsByType(t);for(const i of n){const n=e.getMonomer(t,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][t]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(r.e.colourPalette))}get(t,e){const n=c.palette.length,i=c.customMonomerColors[t],r=e??"PEPTIDE";if(i&&i[r])return i[r];const o=a.hashCode(t)%n;return s(c.palette[o])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(t,e,n)=>{"use strict";n.d(e,{BG:()=>s,sD:()=>l});var i=n(4328),r=n(1858),o=n(8070);function s(t){let e=null,n=null;try{n=t.dart?t.gridColumn:null,e=n?n.temp:null}catch{[n,e]=[null,null]}const i=t.cell.column;if(e=e??(i?i.temp:null),!e)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,e]}class a{onKeyDown(t,e){}onKeyPress(t,e){}onMouseEnter(t,e){}onMouseLeave(t,e){}onMouseDown(t,e){}onMouseUp(t,e){}onMouseMove(t,e){}onClick(t,e){}onDoubleClick(t,e){}}class l extends a{constructor(t,e,n){super(),this.gridCol=t,this.tableCol=e,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((t=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(t){this.logger.error(t)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((t=>{try{const e=t.args.dataFrame;this.tableCol?.dataFrame.id!==e.id||this.destroyed||this.destroy()}catch(t){this.logger.error(t)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((t=>{try{const e=t.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===e.id&&!this.destroyed&&this.destroy()}catch(t){this.logger.error(t)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const t of this.subs)t.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(t){this.invalidateGrid()}async awaitRendered(t=1e4,e=`${t} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,o.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),t,`${n}, ${e}`),this.errors.length>0){const t=this.errors[0];throw this.errors=[],t}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(t,e,n)=>{"use strict";n.d(e,{s:()=>i});const i={true:"1",false:"0"}},6882:(t,e,n)=>{"use strict";n.d(e,{Jy:()=>b,S$:()=>y,U0:()=>v});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553),g=n(9713);const y="rgb(100,100,100)";class b extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(t,e,n,i,o){super(t,e,n),this.monomerLengthLimit=i,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.sysMonomerLib=null,this.padding=5,this._leftThreeDotsPadding=0,this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol&&(this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{const t=this.tableCol.dataFrame;this.gridCol.grid,-1===t.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())}))),this.subs.push(r.debounce(this.tableCol.dataFrame.onMetadataChanged.pipe(g.filter((t=>t.args.source===this.tableCol&&t.args.key===l.gp.positionShift))),200).subscribe((t=>{this.reset()}))))}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const t=await(0,h.pj)();this.sysMonomerLib=t.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(t){let e=12;return t&&t.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(e=Math.max(t.temp[".mm.cellRenderer.fontSize"],1)),{font:`${e}px monospace`,fontWidth:.6*e}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<e&&(this.colWidth=e,this.dirty=!0),this.dirty)try{this.reset()}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(t);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(t){const e=new Array(t.length+1);e[0]=this.padding;for(let n=1;n<e.length;n++)e[n]=e[n-1]+t[n-1];let n=e[0];for(let t=1;t<e.length;t++)e[t]?n=e[t]:e[t]=n;return e}getCellMonomerLengthsForSeq(t){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const e=this.positionShift,n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=Math.ceil(this.colWidth/i)+e,o=n.getSplitted(t),s=Math.min(r,o.length);let a=this._monomerLengthList[t];if(null===a||a.length!=s-e){a=this._monomerLengthList[t]=new Array(o.length);let i=0;for(let t=e;t<s;++t){const r=o.getOriginal(t),s=this.props.monomerToShort(r,this.monomerLengthLimit),l=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+s.length*this.props.fontCharWidth;if(a[t-e]=l,i+=l,i>this.colWidth)break}}return a}getCellMonomerLengthsForSeqValue(t,e){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=this.positionShift,o=Math.ceil(e/i)+r,s=n.splitter(t),a=Math.min(o,s.length),l=new Array(a-r);let c=0;for(let t=r;t<a;++t){const i=s.getOriginal(t),o=this.props.monomerToShort(i,this.monomerLengthLimit),a=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+o.length*this.props.fontCharWidth;if(l[t-r]=a,c+=a,c>e)break}return l}getCellMonomerLengthsForSeqMsa(){var t;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(t=this._monomerLengthList)[0]??(t[0]=new Array(0));const e=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const t=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return t&&t.dart?{startIdx:Math.max(Math.floor((t?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((t?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(t){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=this.positionShift,s=Math.ceil(this.colWidth/r)+o;for(let t=n;t<i;t++){if(this._processedRows.get(t)&&s<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t,s),i=Math.min(s,n.length);i-o>e.length&&e.push(...new Array(i-o-e.length).fill(r));let a=0;for(let t=o;t<i;++t){const i=n.getOriginal(t),r=this.props.monomerToShort(i,this.monomerLengthLimit),s=this.props.separatorWidth+r.length*this.props.fontCharWidth;if(e[t-o]=Math.max(e[t-o]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s),this._processedRows.set(t,!0)}return e}getPosition(t,e,n,i){const[r,o]=this.getCellMonomerLengths(t,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(t).length?null:function(t,e,n){if((n??0)>0&&e<(t[0]??0)+n)return-1;e-=n??0;let i,r=100,o=0,s=t.length-1;for(;o<=s;){if(i=Math.floor((s+o)/2),t[i]<=e&&e<t[i+1])return i;if(e<t[i]?s=i-1:o=i+1,--r<=0)throw new Error(`Get position for pointer x = ${e} searching has not converged on ${JSON.stringify(t)}. `)}return null}(o,e,i)}setMonomerLengthLimit(t){this.monomerLengthLimit!=t&&(this.monomerLengthLimit=t,this.dirty=!0)}setSeparatorWidth(t){this.separatorWidth!=t&&(this.props.separatorWidth=t,this.dirty=!0)}get positionShift(){const t=Number.parseInt(this.tableCol?.tags[l.gp.positionShift]??"0")??0;return isNaN(t)?0:Math.max(t,0)}render(t,e,n,i,r,o,a){const c=o.grid?.canvas===t.canvas;if(!this.seqHelper)return;const h=this.gridCol,m=this.tableCol,f=window.devicePixelRatio,g=this.positionShift,b=`${this.toLog()}.render()`;this.logger.debug(`${b}, start`);let w=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const t=parseInt(m.getTag(d.gp.maxMonomerLength));w=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const t=m.temp[".mm.cellRenderer.maxMonomerLength"];w=!isNaN(t)&&t?t:50}t.save();try{const a=this.seqHelper.getSeqHandler(m);if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=w){let t=0;const e=8;t=m.temp[".mm.cellRenderer.gapLength"]??t,this.setMonomerLengthLimit(w),this.setSeparatorWidth(a.isMsa()?e:t),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false}let[u,b]=this.getCellMonomerLengths(o.tableRowIndex,i);u.length;const C=o.cell.value,A=o.cell.rowIndex,S=(m.getTag(l.gp.alphabet),50);c&&(i=v(h?.grid,t,e,i,f)),t.beginPath(),t.rect(e+this.padding,n,i-this.padding-1,r),t.clip(),t.font=this.props?.font??"12px monospace",t.textBaseline="top";const x=m.meta.units,E=m.getTag(l.gp.aligned),M=m.getTag(l.gp.separator)??"",_=this.props.separatorWidth+1*this.props.fontCharWidth,I=Math.ceil(i/_)+g,T=m.temp["reference-sequence"],L=this.tableCol.temp["current-word"];L&&-1===m?.dataFrame?.currentRowIdx&&(this.tableCol.temp["current-word"]=null);const N=(()=>{const t=a.getSplitter(I)(null!=T&&""!=T?T:L??"");return s().count(0).take(t.length).slice(g).map((e=>t.getOriginal(e))).toArray()})(),P=c?a.getSplitted(A):a.splitter(C);c||(b=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(C,i)));let $=d.yg.classic;E&&E.includes("MSA")&&x==l.Hi.SEPARATOR&&($=d.yg.MSA),this._leftThreeDotsPadding=this.shouldRenderShiftedThreeDots(g)?t.measureText("...").width:0;const R=Number.parseInt(m.getTag(l.gp.selectedPosition)??"-200"),O=Math.min(P.length,I);for(let s=g;s<O;++s){const l=s<P.length?P.getOriginal(s):a.defaultGapOriginal,c=s<P.length?P.getCanonical(s):a.defaultGapOriginal;let h=y;const u=this.getMonomerLib();if(u){const t=a.defaultBiotype;h=u.getMonomerTextColor(t,c)}t.fillStyle=y;const p={color:h,pivot:0,left:!0,transparencyRate:1,separator:M,last:s===P.length-1,drawStyle:$,maxWord:b,wordIdx:s-g,gridCell:o,referenceSequence:N,maxLengthOfMonomer:w,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger,selectedPosition:isNaN(R)||R<1?void 0:R-g};if((0,d.oZ)(t,l,e+this.padding+this._leftThreeDotsPadding,n,i,r,p),S>i)break}if(this.shouldRenderShiftedThreeDots(g)){const s={color:y,pivot:0,left:!0,transparencyRate:1,separator:M,last:!1,drawStyle:$,maxWord:b,wordIdx:0,gridCell:o,maxLengthOfMonomer:w,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};(0,d.oZ)(t,"...",e+this.padding,n,i,r,s)}}catch(t){const[e,n]=(0,u.AP)(t);this.logger.error(e,void 0,n),this.errors.push(t)}finally{t.restore()}}shouldRenderShiftedThreeDots(t){return t>0&&(!this.gridCol||!this.gridCol.dart||!this.gridCol.grid||!this.gridCol.grid.dart||(this.gridCol.grid.props.colHeaderHeight??0)<=50)}onMouseMove(t,e){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==t.tableRowIndex)return;const r=this.positionShift,o=t.bounds,s=e.offsetX-t.gridColumn.left+(t.gridColumn.left-o.x),a=this.shouldRenderShiftedThreeDots(r)&&(this._leftThreeDotsPadding??0)>0?this._leftThreeDotsPadding:0,c=this.getPosition(t.tableRowIndex,s,o.width,a);this.logger.debug(`${n}, start, argsX: ${s}, left: ${c}`);const h=this.seqHelper.getSeqHandler(this.tableCol),u=h.getSplitted(t.tableRowIndex);if(null!==c&&c>=0&&c+r<u.length){const n=h.alphabet??l.YI.UN,o={position:c,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:u.getCanonical(c+r)},s=[];let a=this._monomerStructureMap[o.symbol];{const t=this.getMonomerLib();a=this._monomerStructureMap[o.symbol]=t?t.getTooltip(o.biotype,o.symbol):i.divText("Monomer library is not available")}s.push(a),i.tooltip.show(i.divV(s),e.x+16,e.y+16),(0,f.WN)(t,o)}else-1===c?i.tooltip.show(i.divText(`${Math.min(r,u.length)} hidden monomers`),e.x+16,e.y+16):i.tooltip.hide(),(0,f.WN)(t,null)}}function v(t,e,n,i,r){return t?Math.max(Math.min(t.canvas.width/r-n,i)):Math.max(e.canvas.width/r-n,0)}},3856:(t,e,n)=>{"use strict";n.d(e,{Mn:()=>c,gp:()=>l,oZ:()=>d,yg:()=>h});var i=n(6082),r=n(7278);const o="#808080",s="rgb(0,0,0)",a=r.zS;var l,c,h;!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(l||(l={})),function(t){t.applyToBackground=".m.cellRenderer.applyToBackground"}(c||(c={})),function(t){t.MSA="MSA",t.classic="classic"}(h||(h={}));const u=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=h.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0,this.selectedPosition=void 0}};function d(t,e,n,r,l,c,d){var p,m,f;const g=Object.assign(Object.assign({},u),d);d.logger?.debug("Bio: printLeftOrCentered(), start"),t.textAlign="start";let y=e.substring(0),b=g.last?"":g.separator;g.drawStyle===h.MSA&&(b="");let v=!0,w=!0,C="difference";if(null!=g.gridCell&&null!=g.gridCell.cell.column&&(v=g.gridCell.cell.column.temp["color-code"]??!0,w=g.gridCell.cell.column.temp["compare-with-current"]??!0,C=g.gridCell.cell.column.temp["highlight-difference"]??"difference"),g.referenceSequence){const t=g.referenceSequence[g.wordIdx];w&&g.referenceSequence.length>0&&"difference"===C&&(g.transparencyRate=y==t?.3:g.transparencyRate),w&&g.referenceSequence.length>0&&"equal"===C&&(g.transparencyRate=y!=t?.3:g.transparencyRate)}null!=g.maxLengthOfMonomer&&(y=a(y,g.maxLengthOfMonomer));const A=y+b;(p=g.monomerTextSizeMap)[A]??(p[A]=t.measureText(A));let S=g.monomerTextSizeMap[A];(m=g.monomerTextSizeMap)[y]??(m[y]=t.measureText(y));let x=g.monomerTextSizeMap[y].width;const E=c/2-(S.fontBoundingBoxAscent+S.fontBoundingBoxDescent)/2+1;(f=g.monomerTextSizeMap)[b]??(f[b]=t.measureText(b));const M=g.monomerTextSizeMap[b].width;function _(e,a){let l=v?g.color:s;g.selectedPosition===g.wordIdx+1&&(t.fillStyle="rgba(60, 177, 115, 0.2)",t.fillRect(n+e-4,r-5,g.monomerTextSizeMap[y].width+8,c+10),l=i.Color.toHtml(i.Color.setAlpha(i.Color.fromHtml(l),255))),t.fillStyle=l,t.globalAlpha=g.transparencyRate,g.drawStyle===h.classic&&(t.fillText(y,n+e,r+E),t.fillStyle=o,t.fillText(b,n+a,r+E)),g.drawStyle===h.MSA&&t.fillText(y,n+e,r+E)}S=S.width,g.drawStyle===h.MSA&&(x=g.maxWord[g.wordIdx],S=g.maxWord[g.wordIdx]);const I=(g.maxWord[g.wordIdx]??0)-(g.maxWord[0]??0);if(g.left||S>l)return _(I,I+x),n+I+x+M;{const t=(l-S)/2;return _(t,t+x),n+I+t+x}}},3151:(t,e,n)=>{"use strict";n.d(e,{EK:()=>l,Ec:()=>o,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>r});const i=["symbol","molfile","rgroups","name"],r="MonomerName",o={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(t,e,n)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function r(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?r(t.$thrownJsError):void 0}function o(t){return[i(t),r(t)]}n.d(e,{AP:()=>o})},3516:(t,e,n)=>{"use strict";n.d(e,{m:()=>o});var i=n(6082),r=n(439);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(t,e){return this._fileContent.slice(t,e).split(/\s/).join("")}parseColumns(){const t=/^>(.*)$/gm;let e,n=0;for(;e=t.exec(this._fileContent);){const i=this._fileContent.substring(e.index+1,t.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,e.index)),n=t.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const t=i.Column.fromStrings("description",this.descriptionsArray),e=i.Column.fromStrings("sequence",this.sequencesArray);return e.semType=i.SEMTYPE.MACROMOLECULE,e.meta.units=r.Hi.FASTA,[i.DataFrame.fromColumns([t,e])]}constructor(t){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=t,this.parseColumns()}}},6873:(t,e,n)=>{"use strict";n.d(e,{Hx:()=>h,dW:()=>c});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(7278),l=n(439);function c(t=10**5){const e="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(t/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function h(t,e=s.Hi.SEPARATOR,n=s.YI.PT,r=(e===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=e,f.setTag(s.gp.alphabet,n),e==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,r);const g=t.getSeqHandler(f);for(let t=0;t<u;t++){const n=o().count(0).take(d).map((t=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[e]));f.set(t,i)}return f}},439:(t,e,n)=>{"use strict";n.d(e,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>r,_S:()=>u,b9:()=>d,gp:()=>o,q7:()=>h,z1:()=>a});var i,r,o,s=n(2738);!function(t){t.FASTA="fasta",t.SEPARATOR="separator",t.HELM="helm",t.CUSTOM="custom"}(i||(i={})),function(t){t.DNA="DNA",t.RNA="RNA",t.PT="PT",t.UN="UN"}(r||(r={})),function(t){t.aligned="aligned",t.alphabet="alphabet",t.alphabetSize=".alphabetSize",t.alphabetIsMultichar=".alphabetIsMultichar",t.separator="separator",t.isHelmCompatible=".isHelmCompatible",t.positionNames=".positionNames",t.positionLabels=".positionLabels",t.regions=".regions",t.positionShift=".positionShift",t.selectedPosition=".selectedPosition"}(o||(o={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(r.PT,c.fasta.peptide,.5),new s.a(r.DNA,c.fasta.dna,.55),new s.a(r.RNA,c.fasta.rna,.55)],u="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"}},2003:(t,e,n)=>{"use strict";n.d(e,{Hi:()=>i.Hi,J9:()=>r.J9,Qf:()=>r.Qf,YI:()=>i.YI,dh:()=>r.dh,gp:()=>i.gp,mn:()=>r.mn,q7:()=>i.q7,qp:()=>r.qp,z1:()=>i.z1,zS:()=>r.zS});var i=n(439),r=n(7278)},2738:(t,e,n)=>{"use strict";n.d(e,{X:()=>r,a:()=>i});class i{constructor(t,e,n){this.name=t,this.alphabet=e,this.cutoff=n}}class r extends i{constructor(t,e,n){super(t.name,t.alphabet,t.cutoff),this.freq=e,this.similarity=n}}},7278:(t,e,n)=>{"use strict";n.d(e,{Iv:()=>y,J9:()=>p,Mu:()=>u,Qf:()=>w,dh:()=>f,mn:()=>S,p0:()=>A,pc:()=>C,qp:()=>g,tm:()=>m,zS:()=>v});var i=n(6082),r=n(1991),o=n.n(r),s=n(3527),a=n(3629),l=n(2738),c=n(439),h=(n(8924),n(1093),n(4152),n(8438));class u{get length(){return this.mList.length}isGap(t){return this.getOriginal(t)===this.gapOriginalMonomer}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");const e=this.mList[t];return e!==this.gapOriginalMonomer?e:c._S}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.mList[t]}constructor(t,e){this.mList=t,this.gapOriginalMonomer=e}}class d{get length(){return this.seqS.length}isGap(t){return this.getOriginal(t)===c.b9[c.Hi.FASTA]}getCanonical(t){if(this.length<=t)throw new Error("Index out of bounds");return this.isGap(t)?c._S:this.seqS[t]}getOriginal(t){if(this.length<=t)throw new Error("Index out of bounds");return this.seqS[t]}constructor(t){this.seqS=t}}const p=t=>{const e=o()(t.toString().matchAll(c.B5)).map((t=>t[2]??t[1])).toArray();return new u(e,c.b9[c.Hi.FASTA])},m=t=>t?new d(t):new u([],c.b9[c.Hi.FASTA]);function f(t,e=void 0){return n=>{if(n){let i;const r=new RegExp(`(?<=^|\\${t})("-"|'-'|[^\\${t}]*)(?=\\${t}|$)`,"g");return void 0!==e?(r.lastIndex=0,i=o()(n.matchAll(r)).take(e).map((t=>t[0])).toArray()):i=n.replaceAll('"-"',"").replaceAll("'-'","").split(t,e),new u(i,c.b9[c.Hi.SEPARATOR])}return new u([],c.b9[c.Hi.SEPARATOR])}}const g=t=>{const e=t.split("$")[0].split("|"),n=o()(e.map((t=>(t.match(/(?<=\{).+(?=})/)?.[0]?.split(".")??[]).map((t=>(0,h.D)(t)))))).flatten().toArray();return new u(n,c.b9[c.Hi.HELM])};function y(t,e,n=void 0){if(t.toLowerCase().startsWith(c.Hi.FASTA))return p;if(t.toLowerCase().startsWith(c.Hi.SEPARATOR))return f(e,n);if(t.toLowerCase().startsWith(c.Hi.HELM))return g;throw new Error(`Unexpected units ${t} .`)}const b=/([^\W_]+)/g;function v(t,e){if(t.length<=e)return t;const n=t.match(b),i=t.length>e||(n?.length??0)>1,r=n?.[0]??" ";return i?r.substring(0,e-1)+"…":r}function w(t){switch(t){case c.YI.DNA:return c.Vl.fasta.dna;case c.YI.RNA:return c.Vl.fasta.rna;case c.YI.PT:return c.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${t}'.`)}}function C(t,e,n="-"){const i=e.map((e=>{const i=function(t,e,n="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(n);const r=[],o=[];for(const n of i)r.push(n in t?t[n]:0),o.push(e.has(n)?1:0);const l=new s.Mi(r),c=new s.Mi(o);return(0,a.KE)(l,c)/((0,a.wQ)(l)*(0,a.wQ)(c))}(t,e.alphabet,n);return new l.X(e,t,i)}));let r;const o=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return r=o>0?i.find((t=>t.similarity===o)).name:c.YI.UN,r}function A(t,e,n="-"){const i=Object.keys(t),r=/\(|\)/;return C(i.filter((t=>3===t.split(r).filter((t=>!!t)).length)).length>.8*i.length?Object.entries(t).reduce(((t,[e,n])=>{const i=e.split(r)[1];return i&&(t[i]=n),t}),{}):t,e,n)}function S(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=e.find((t=>{const e=t.meta.units;return!!e&&-1!==e.indexOf("MSA")}))??null;return!n&&e.length>0&&(n=e[0]),n}},8312:(t,e,n)=>{"use strict";n.d(e,{Q:()=>r});var i=n(6082);async function r(){const t=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===t.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await t[0].prepare().call()).getOutputParamValue()}},3077:(t,e,n)=>{"use strict";n.d(e,{R:()=>r});var i=n(6082);function r(t,e){const n=t=>{const e=s.columns.addNewString((t+1).toString());return r.push(e),e},r=[],o=t.length,s=i.DataFrame.create(o),a=e.getSeqHandler(t);for(let t=0;t<o;++t){const e=a.getSplitted(t);for(let i=0;i<e.length;++i){const o=e.getCanonical(i);((r[i]??null)||n(i)).set(t,o,!1)}}return s}},7602:(t,e,n)=>{"use strict";n.d(e,{g:()=>o});var i,r=n(9192);!function(t){t[t.error=0]="error",t[t.warning=1]="warning",t[t.info=2]="info",t[t.debug=3]="debug"}(i||(i={}));class o{constructor(t){this.logger=t,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(t,e){const n=++this.syncCounter;this.logger.debug(`${t}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${t}, SYNC syncId = ${n}, START `),await e(),this.logger.debug(`${t}, SYNC syncId = ${n}, END `)})).catch((e=>{const[i,o]=(0,r.AP)(e);this.logger.error(`${t}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,o),this.errors.push(e)}))}resetErrors(){const t=this.errors;return this.errors=[],t}}},4326:(t,e,n)=>{"use strict";n.d(e,{Fo:()=>h,Lp:()=>o,P4:()=>s,fH:()=>r,gp:()=>i,lT:()=>l,mH:()=>a});var i,r,o,s,a,l,c=n(6082);!function(t){t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(r||(r={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(o||(o={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(s||(s={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=20,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=25,this.maxHeight=300,this.maxMonomerLetters=5,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},6869:(t,e,n)=>{"use strict";var i;n.d(e,{o:()=>i}),function(t){t.BASE="HELM_BASE",t.SUGAR="HELM_SUGAR",t.LINKER="HELM_LINKER",t.AA="HELM_AA",t.CHEM="HELM_CHEM",t.BLOB="HELM_BLOB",t.NUCLEOTIDE="HELM_NUCLETIDE"}(i||(i={}))},5540:(t,e,n)=>{"use strict";t=n.hmd(t);var i,r=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(t={}){var e,n,r=void 0!==t?t:{};r.ready=new Promise((function(t,i){e=t,n=i}));var o,s=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(o=t=>{var e=new XMLHttpRequest;return e.open("GET",t,!1),e.responseType="arraybuffer",e.send(null),new Uint8Array(e.response)})),r.print||console.log.bind(console);var h,u,d=r.printErr||console.warn.bind(console);Object.assign(r,s),s=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(h=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&M("no native wasm support detected");var p,m,f,g=!1;function y(){var t=u.buffer;r.HEAP8=p=new Int8Array(t),r.HEAP16=new Int16Array(t),r.HEAP32=new Int32Array(t),r.HEAPU8=m=new Uint8Array(t),r.HEAPU16=new Uint16Array(t),r.HEAPU32=f=new Uint32Array(t),r.HEAPF32=new Float32Array(t),r.HEAPF64=new Float64Array(t)}var b,v,w=[],C=[],A=[],S=0,x=null,E=null;function M(t){r.onAbort&&r.onAbort(t),d(t="Aborted("+t+")"),g=!0,t+=". Build with -sASSERTIONS for more info.";var e=new WebAssembly.RuntimeError(t);throw n(e),e}function _(t){return t.startsWith("data:application/octet-stream;base64,")}function I(t){try{if(t==b&&h)return new Uint8Array(h);if(o)return o(t);throw"both async and sync fetching of the wasm failed"}catch(t){M(t)}}function T(t,e,n){return function(t){return h||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return I(t)})):fetch(t,{credentials:"same-origin"}).then((function(e){if(!e.ok)throw"failed to load wasm binary file at '"+t+"'";return e.arrayBuffer()})).catch((function(){return I(t)}))}(t).then((function(t){return WebAssembly.instantiate(t,e)})).then((function(t){return t})).then(n,(function(t){d("failed to asynchronously prepare wasm: "+t),M(t)}))}function L(t){for(;t.length>0;)t.shift()(r)}function N(t){this.excPtr=t,this.ptr=t-24,this.set_type=function(t){f[this.ptr+4>>2]=t},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(t){f[this.ptr+8>>2]=t},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(t){t=t?1:0,p[this.ptr+12|0]=t},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(t){t=t?1:0,p[this.ptr+13|0]=t},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(t,e){this.set_adjusted_ptr(0),this.set_type(t),this.set_destructor(e)},this.set_adjusted_ptr=function(t){f[this.ptr+16>>2]=t},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(D(this.get_type()))return f[this.excPtr>>2];var t=this.get_adjusted_ptr();return 0!==t?t:this.excPtr}}function P(t){var e=u.buffer;try{return u.grow(t-e.byteLength+65535>>>16),y(),1}catch(t){}}function $(t){return r["_"+t]}_(b="wasmDbscan.wasm")||(v=b,b=r.locateFile?r.locateFile(v,c):c+v);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(t,e,n,i,r){var o={string:t=>{var e=0;return null!=t&&0!==t&&(e=function(t){var e=function(t){for(var e=0,n=0;n<t.length;++n){var i=t.charCodeAt(n);i<=127?e++:i<=2047?e+=2:i>=55296&&i<=57343?(e+=4,++n):e+=3}return e}(t)+1,n=B(e);return function(t,e,n){!function(t,e,n,i){if(!(i>0))return 0;for(var r=n+i-1,o=0;o<t.length;++o){var s=t.charCodeAt(o);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&t.charCodeAt(++o)),s<=127){if(n>=r)break;e[n++]=s}else if(s<=2047){if(n+1>=r)break;e[n++]=192|s>>6,e[n++]=128|63&s}else if(s<=65535){if(n+2>=r)break;e[n++]=224|s>>12,e[n++]=128|s>>6&63,e[n++]=128|63&s}else{if(n+3>=r)break;e[n++]=240|s>>18,e[n++]=128|s>>12&63,e[n++]=128|s>>6&63,e[n++]=128|63&s}}e[n]=0}(t,m,e,n)}(t,n,e),n}(t)),e},array:t=>{var e,n,i=B(t.length);return e=t,n=i,p.set(e,n),i}},s=$(t),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var h=o[n[c]];h?(0===l&&(l=F()),a[c]=h(i[c])):a[c]=i[c]}var u=s.apply(null,a);return function(t){return 0!==l&&H(l),function(t){return"string"===e?(n=t)?function(t,e,n){for(var i=e+n,r=e;t[r]&&!(r>=i);)++r;if(r-e>16&&t.buffer&&R)return R.decode(t.subarray(e,r));for(var o="";e<r;){var s=t[e++];if(128&s){var a=63&t[e++];if(192!=(224&s)){var l=63&t[e++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&t[e++])<65536)o+=String.fromCharCode(s);else{var c=s-65536;o+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else o+=String.fromCharCode((31&s)<<6|a)}else o+=String.fromCharCode(s)}return o}(m,n,i):"":"boolean"===e?Boolean(t):t;var n,i}(t)}(u)}var k,G={__cxa_throw:function(t,e,n){throw new N(t).init(e,n),t},abort:function(){M("")},emscripten_memcpy_big:function(t,e,n){m.copyWithin(t,e,e+n)},emscripten_resize_heap:function(t){var e,n=m.length,i=2147483648;if((t>>>=0)>i)return!1;for(var r=1;r<=4;r*=2){var o=n*(1+.2/r);if(o=Math.min(o,t+100663296),P(Math.min(i,(e=Math.max(t,o))+(65536-e%65536)%65536)))return!0}return!1}},F=(function(){var t,e,i,o,s={env:G,wasi_snapshot_preview1:G};function a(t,e){var n,i=t.exports;return r.asm=i,u=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,C.unshift(n),function(){if(S--,r.monitorRunDependencies&&r.monitorRunDependencies(S),0==S&&(null!==x&&(clearInterval(x),x=null),E)){var t=E;E=null,t()}}(),i}if(S++,r.monitorRunDependencies&&r.monitorRunDependencies(S),r.instantiateWasm)try{return r.instantiateWasm(s,a)}catch(t){d("Module.instantiateWasm callback failed with error: "+t),n(t)}(t=h,e=b,i=s,o=function(t){a(t.instance)},t||"function"!=typeof WebAssembly.instantiateStreaming||_(e)||"function"!=typeof fetch?T(e,i,o):fetch(e,{credentials:"same-origin"}).then((function(t){return WebAssembly.instantiateStreaming(t,i).then(o,(function(t){return d("wasm streaming compile failed: "+t),d("falling back to ArrayBuffer instantiation"),T(e,i,o)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(F=r.asm.stackSave).apply(null,arguments)}),H=function(){return(H=r.asm.stackRestore).apply(null,arguments)},B=function(){return(B=r.asm.stackAlloc).apply(null,arguments)},D=function(){return(D=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function t(){k||(k=!0,r.calledRun=!0,g||(L(C),e(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)t=r.postRun.shift(),A.unshift(t);var t;L(A)}()))}S>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)t=r.preRun.shift(),w.unshift(t);var t;L(w)}(),S>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),t()}),1)):t()))}if(r.ccall=O,r.cwrap=function(t,e,n,i){var r=!n||n.every((t=>"number"===t||"boolean"===t));return"string"!==e&&r&&!i?$(t):function(){return O(t,e,n,arguments)}},E=function t(){k||V(),k||(E=t)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return V(),t.ready});"object"==typeof exports?t.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6295:(t,e,n)=>{"use strict";n.d(e,{$1:()=>a,Hf:()=>u,Hr:()=>M,Ii:()=>y,Qj:()=>f,T6:()=>E,TK:()=>S,be:()=>g,gt:()=>w,iS:()=>s,ij:()=>C,jL:()=>h,lO:()=>m,lP:()=>v,rR:()=>b,tO:()=>l,v_:()=>c,w_:()=>d,yK:()=>A,zn:()=>p});var i=n(8774),r=n(8498),o=n(6863);r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean,r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean;const s=[r.aT.Tanimoto,r.aT.Dice,r.aT.Cosine];function a(t,e){const n=t.trueCount()+e.trueCount();if(0==n)return 1;const i=t.andWithCountBits(e,!0);return i/(n-i)}function l(t,e){return 1-a(t,e)}function c(t,e){return x(a(new i.A(t,32*t.length),new i.A(e,32*e.length)))}function h(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.pow(t[i]-e[i],2);return Math.sqrt(n)}function u(t,e){let n=0;for(let i=0;i<t.length;i++)n+=Math.abs(t[i]-e[i]);return n}function d(t,e){let n=0,i=0,r=0;for(let o=0;o<t.length;o++)n+=t[o]*e[o],i+=t[o]*t[o],r+=e[o]*e[o];return(1-n/(Math.sqrt(i)*Math.sqrt(r)))/2}function p(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount();return 0==n?0:2*t.andWithCountBits(e,!0)/n}(t,e)}function m(t,e){return 1-function(t,e){const n=t.trueCount()*e.trueCount();return 0==n?0:t.andWithCountBits(e,!0)/Math.sqrt(n)}(t,e)}function f(t,e){return Math.sqrt(t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0))}function g(t,e){return t.trueCount()+e.trueCount()-2*t.andWithCountBits(e,!0)}function y(t,e){return 1-function(t,e){const n=t.trueCount()+e.trueCount(),i=t.andWithCountBits(e,!0);return i/(2*n-3*i)}(t,e)}function b(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:t.andWithCountBits(e,!0)*n/(2*i)}(t,e))}function v(t,e){return x(function(t,e){const n=t.trueCount()+e.trueCount(),i=t.trueCount()*e.trueCount();return 0==i?0:(t.andWithCountBits(e,!0)*n-i)/i}(t,e))}function w(t,e){return 1-function(t,e){const n=Math.min(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e)}function C(t,e){return x(function(t,e){const n=Math.max(t.trueCount(),e.trueCount());return 0==n?0:t.andWithCountBits(e,!0)/n}(t,e))}function A(t,e){return x(function(t,e){return 0==t.length?0:t.andWithCountBits(e,!0)/t.length}(t,e))}function S(t,e){return x(function(t,e){const n=t.andWithCountBits(e,!0),i=t.countBits(!0)+e.countBits(!0),r=t.length,o=r-i+n;return n==r||o==r?1:n/i+o/(2*r-i)}(t,e))}function x(t){return t<=0?3402823e32:1/t-1}function E(t){if(t&&null!=t.range&&t.range>0){const e=t.range;return(t,n)=>Math.abs(t-n)/e}return(t,e)=>Math.abs(t-e)}function M(t){const e=function(t){const e=t?.mostCommon??new Set;return(t,n)=>{const i=t.length,r=n.length;let o=0,s=0,a=0;for(;s<i&&a<r;)t[s]===n[a]?(e?.has(t[s])||++o,++s,++a):t[s]<n[a]?++s:++a;return o}}(t);return(t,n)=>0===n.length||0===t.length?1e4:Math.min(t.length,n.length)/(e(t,n)+1e-4)}r.aT.Tanimoto,r.aT.Asymmetric,r.aT.Cosine,r.aT.Sokal,o.Z.HAMMING,o.Z.LEVENSHTEIN,o.Z.MONOMER_CHEMICAL_DISTANCE,o.Z.NEEDLEMANN_WUNSCH},684:(t,e,n)=>{"use strict";n.d(e,{C0:()=>o,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>r,vb:()=>l});const i="dim-red-preprocessing-function",r="supportedSemTypes",o="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(t,e,n)=>{"use strict";function i(t={}){const e=function(){if(!t||!t.scoringMatrix||!t.alphabetIndexes)return(t,e)=>t===e?0:1;if(t.scoringMatrix.length!==Object.keys(t.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const e=t.alphabetIndexes,n=t.scoringMatrix,i=Math.min(...Object.keys(e).map((t=>t.charCodeAt(0))))+1,r=new Float32Array((n.length+i)*(n.length+i));return Object.entries(e).forEach((([t,i])=>{const o=n[i];Object.entries(e).forEach((([e,i])=>{r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]=o[i]}))})),(t,e)=>1-r[t.charCodeAt(0)*n.length+e.charCodeAt(0)]}(),n=t?.threshold??0;return(t,i)=>{let r=0;const o=t.length,s=i.length,a=Math.ceil(Math.max(o,s)*(1-n));o!==s&&(r=Math.abs(o-s));let l=0;for(let n=0;n<Math.min(o,s);n++)if(t[n]!==i[n]&&(l+=e(t[n],i[n]),l>a))return 1;return l+=r,l/=Math.max(o,s),l}}n.d(e,{Z:()=>s,V:()=>a});var r=n(2787);const o={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(t){t.HAMMING="Hamming",t.LEVENSHTEIN="Levenshtein",t.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",t.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(t,e)=>(0,r.I)(t,e)/Math.max(t.length,e.length)},[s.NEEDLEMANN_WUNSCH]:function(t){const e=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:r,alphabetIndexes:s}={...o,...t};Object.entries(s).forEach((([t,n])=>e[t.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(t,o)=>{const s=new Array(t.length+1).fill(!1),l=new Array(t.length+1).fill(!1);let c=0,h=1;for(let e=1;e<t.length+1;e++)a[0][e]=-i-(e-1)*i,a[1][e]=0;a[0][0]=0;for(let u=1;u<o.length+1;u++){a[h][0]=-i-(u-1)*i;for(let d=1;d<t.length+1;d++){const p=a[c][d-1]+r[e[t.charCodeAt(d-1)]][e[o.charCodeAt(u-1)]],m=a[c][d]-(s[d]||1===u||u===o.length?i:n),f=a[h][d-1]-(l[d-1]||1===d||d===t.length?i:n);a[h][d]=Math.max(p,f,m),a[h][d]===p?(s[d]=!1,l[d]=!1):a[h][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=h,h=(h+1)%2}const u=Math.min(t.length,o.length);return(u-a[c][t.length])/u}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},8060:(t,e,n)=>{"use strict";n.d(e,{S:()=>i});const i="dimensionality-reducer-terminate-event"},9039:(t,e,n)=>{"use strict";var i;n.d(e,{c:()=>i}),function(t){t.UMAP="UMAP",t.T_SNE="t-SNE"}(i||(i={}))},8498:(t,e,n)=>{"use strict";var i,r,o,s,a,l,c;n.d(e,{EG:()=>a,Pn:()=>r,RR:()=>l,Wn:()=>c,aT:()=>o,m6:()=>s,xL:()=>i}),function(t){t.Levenshtein="Levenshtein",t.JaroWinkler="Jaro-Winkler",t.Manhattan="Manhattan String",t.Onehot="One-Hot"}(i||(i={})),function(t){t.Euclidean="Euclidean",t.Manhattan="Manhattan",t.Cosine="Vector Cosine"}(r||(r={})),function(t){t.Tanimoto="Tanimoto",t.Dice="Dice",t.Asymmetric="Asymmetric",t.BraunBlanquet="Braun-Blanquet",t.Cosine="Cosine",t.Kulczynski="Kulczynski",t.McConnaughey="Mc-Connaughey",t.RogotGoldberg="Rogot-Goldberg",t.Russel="Russel",t.Sokal="Sokal",t.Hamming="Hamming",t.Euclidean="Euclidean BitArray"}(o||(o={})),function(t){t.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(t){t.Vector="Vector",t.String="String",t.BitArray="BitArray",t.MacroMolecule="MacroMolecule",t.Number="Number",t.IntArray="IntArray",t.NumberArray="NumberArray"}(a||(a={})),function(t){t.Difference="Difference"}(l||(l={})),function(t){t.CommonItems="Common Items"}(c||(c={}))},2780:(t,e,n)=>{"use strict";n(8498),n(9336)},9336:(t,e,n)=>{"use strict";var i=n(2787),r=n(944),o=n(6295),s=n(6863),a=n(8498);const l={[a.Pn.Euclidean]:o.jL,[a.Pn.Manhattan]:o.Hf,[a.Pn.Cosine]:o.w_},c={[a.xL.Levenshtein]:i.I,[a.xL.JaroWinkler]:r.Vb,[a.xL.Manhattan]:function(t,e){if(t.length!==e.length)return 1;{let n=0;for(let i=1;i<t.length;i++)n+=t[i]==e[i]?0:1;return n/t.length}},[a.xL.Onehot]:function(t,e){return t===e?0:1}},h={[a.aT.Tanimoto]:o.tO,[a.aT.Dice]:o.zn,[a.aT.Asymmetric]:o.gt,[a.aT.BraunBlanquet]:o.ij,[a.aT.Cosine]:o.lO,[a.aT.Kulczynski]:o.rR,[a.aT.McConnaughey]:o.lP,[a.aT.RogotGoldberg]:o.TK,[a.aT.Russel]:o.yK,[a.aT.Sokal]:o.Ii,[a.aT.Hamming]:o.be,[a.aT.Euclidean]:o.Qj},u={[a.m6.TanimotoIntArray]:o.v_},d={[a.RR.Difference]:o.T6},p={[a.Wn.CommonItems]:o.Hr},m={[a.EG.Vector]:{[a.Pn.Euclidean]:l[a.Pn.Euclidean],[a.Pn.Manhattan]:l[a.Pn.Manhattan],[a.Pn.Cosine]:l[a.Pn.Cosine]},[a.EG.String]:{[a.xL.Levenshtein]:c[a.xL.Levenshtein],[a.xL.JaroWinkler]:c[a.xL.JaroWinkler],[a.xL.Manhattan]:c[a.xL.Manhattan],[a.xL.Onehot]:c[a.xL.Onehot]},[a.EG.BitArray]:{[a.aT.Tanimoto]:h[a.aT.Tanimoto],[a.aT.Dice]:h[a.aT.Dice],[a.aT.Asymmetric]:h[a.aT.Asymmetric],[a.aT.BraunBlanquet]:h[a.aT.BraunBlanquet],[a.aT.Cosine]:h[a.aT.Cosine],[a.aT.Kulczynski]:h[a.aT.Kulczynski],[a.aT.McConnaughey]:h[a.aT.McConnaughey],[a.aT.RogotGoldberg]:h[a.aT.RogotGoldberg],[a.aT.Russel]:h[a.aT.Russel],[a.aT.Sokal]:h[a.aT.Sokal]},[a.EG.MacroMolecule]:{[s.Z.HAMMING]:s.V[s.Z.HAMMING],[s.Z.LEVENSHTEIN]:s.V[s.Z.LEVENSHTEIN],[s.Z.NEEDLEMANN_WUNSCH]:s.V[s.Z.NEEDLEMANN_WUNSCH],[s.Z.MONOMER_CHEMICAL_DISTANCE]:s.V[s.Z.MONOMER_CHEMICAL_DISTANCE]},[a.EG.Number]:{[a.RR.Difference]:d[a.RR.Difference]},[a.EG.IntArray]:{[a.m6.TanimotoIntArray]:u[a.m6.TanimotoIntArray]},[a.EG.NumberArray]:{[a.Wn.CommonItems]:p[a.Wn.CommonItems]}};Object.keys(m).reduce(((t,e)=>{for(const n of Object.keys(m[e]))t[n]=e;return t}),{})},8774:(t,e,n)=>{"use strict";n.d(e,{A:()=>i});class i{constructor(t,e=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof t){const n=t,r=i._createBuffer(n);if(e)for(let t=0;t<r.length;t++)r[t]=-1;this._data=r,this._length=n}else{if(!(t instanceof Uint32Array))throw new Error("Invalid constructor");this._data=t,this._length=e}}getRawData(){return this._data}assureGoez(t,e){if(t<0)throw new Error(`${e} should be greater than zero`)}assureInRange(t,e,n,i){if(t<e||t>n)throw new Error(`Argument ${i} (${t}) out of range (${e}, ${n})`)}copy(t,e,n){for(let i=0;i<n;i++)e[i]=t[i]}copyFrom(t){if(this._length!=t._length)throw new Error(`Lengths differ (${this._length} != ${t._length})`);this.copy(t._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(t){this._data=t,this._version++}get version(){return this._version}set version(t){this._version=t}incrementVersion(t=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(t){this._versionedName=t,this._versionedNameVersion=this._version}get self(){return this}setLength(t){if(t<0)throw new Error("should be >= 0");if(t==this._length)return;const e=Math.floor((t+31)/32);if(e>this._data.length||e+this.SHRINK_THRESHOLD<this._data.length){const t=new Uint32Array(e);this.copy(this._data,t,e>this._data.length?this._data.length:e),this._data=t}t>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,e)),this._length=t,this._version++}static fromAnd(t,e){if(t._length!=e._length)throw new Error(`Lengths differ (${t._length} != ${e._length})`);const n=new i(t._length);n._length=t._length,n._data=i._createBuffer(n._length),n._version=0;const r=t.lengthInInts;for(let i=0;i<r;i++)n._data[i]=t._data[i]&e._data[i];return n}static _createBuffer(t){return new Uint32Array(Math.floor((t+31)/32))}static fromValues(t){const e=new i(t.length);e._version=0;for(let n=0;n<e._length;n++)t[n]&&(e._data[Math.floor(n/32)]|=1<<(n%32&31));return e}static fromSeq(t,e){const n=new i(t);for(let i=0;i<t;++i)n.setBit(i,e(i));return n._version=0,n}static fromString(t){return i.fromSeq(t.length,(e=>"1"==t.charAt(e)))}static fromUint32Array(t,e){const n=new i(t);return n._data=e,n}static fromBytes(t){const e=t.length,n=new i(8*e);n._data=new Uint32Array(Math.floor((e+3)/4)),n._length=8*e;let r=0,o=0;for(;e-o>=4;)n._data[r++]=255&t[o]|(255&t[o+1])<<8|(255&t[o+2])<<16|(255&t[o+3])<<24,o+=4;return e-o==3&&(n._data[r]=(255&t[o+2])<<16),e-o==2&&(n._data[r]|=(255&t[o+1])<<8),e-o==1&&(n._data[r]|=255&t[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(t){if(this==t)return!0;if(null==t)return!1;if(this._length!=t._length)return!1;if(0==this._length)return!0;for(let e=0;e<this._data.length-1;e++)if(this._data[e]!=t._data[e])return!1;for(let e=8*(this._data.length-1);e<this._length;e++)if(this.getBit(e)!=t.getBit(e))return!1;return!0}clone(){const t=new i(0,!1);return t._data=Uint32Array.from(this._data),t._length=this._length,t._version=this._version,t}init(t,e){this.setAll(!1,!1);for(let e=0;e<this._length;e++)t(e)&&(this._data[Math.floor(e/32)]|=1<<(e%32&31));return this.incrementVersion(e),this}invert(t=!0){for(let t=0;t<this._data.length;t++)this._data[t]^=-1;this.incrementVersion(t)}setAll(t,e=!1){const n=t?-1:0,i=this.lengthInInts;for(let t=0;t<i;t++)this._data[t]=n;this.incrementVersion(e)}setIndexes(t,e=!0,n=!0,i=!0){n&&this.setAll(!e,!1);for(const n of t)this.setFast(n,e);this.incrementVersion(i)}everyIndex(t,e=!0){for(const n of t)if(this.getBit(n)!=e)return!1;return!0}anyIndex(t,e=!0){for(const n of t)if(this.getBit(n)==e)return!0;return!1}setWhere(t,e=!0,n=!0,i=!0,r=!0){if(n&&r&&this.setAll(!e,!1),r)for(let n=0;n<this._length;n++)t(n)&&this.setFast(n,e);else for(let n=0;n<this._length;n++)this.setFast(n,t(n)?e:!e);this.incrementVersion(i)}getRange(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(t,e){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length,"to");const n=[];for(let i=t;i<e;++i)n.push(this.getBit(i));return n}setRange(t,e,n,i=!0){this.assureInRange(t,0,this._length-1,"from"),this.assureInRange(e,0,this._length-1,"to");const r=Math.min(t,e),o=Math.max(t,e);if(n)for(let t=r;t<=o;t++)this.setTrue(t);else for(let t=r;t<=o;t++)this.setFalse(t);return this.incrementVersion(i),this}setRandom(t,e,n=!0){if(t<0||t>this._length)throw new Error("n must be >= 0 && <= Count");t>this._length/2&&this.setRandom(this._length-t,!e),this.setAll(!e);for(let n=0;n<t;){const t=Math.floor(Math.random()*this._length);this.getBit(t)!=e&&(this.setFast(t,e),n++)}this.incrementVersion(n)}and(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]&=t._data[e];return this.incrementVersion(e),this}andNot(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let e=0;e<n;e++)this._data[e]&=~t._data[e];return this.incrementVersion(e),this}notAnd(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]=~this._data[e]&t._data[e];return this.incrementVersion(e),this}not(t=!0){for(let t=0,e=this.lengthInInts;t<e;t++)this._data[t]=~this._data[t];return this.incrementVersion(t),this}or(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]|=t._data[e];return this.incrementVersion(e),this}xor(t,e=!0){if(this._length!=t._length)throw new Error("Array lengths differ.");for(let e=0,n=this.lengthInInts;e<n;e++)this._data[e]^=t._data[e];return this.incrementVersion(e),this}insertAt(t,e,n=!1){if(this.assureInRange(t,0,this._length,"pos"),0==e)return;const i=this._length;this.setLength(this._length+e);for(let n=i-1;n>=t;n--)this.setBit(n+e,this.getBit(n));for(let i=t;i<t+e;i++)this.setBit(i,n)}removeAt(t,e=1){if(e<0)throw new Error("n cannot be negative");if(this.assureInRange(t,0,this._length-e,"pos"),this.contains(!0))for(let n=t;n<this._length-e;n++)this.setBit(n,this.getBit(n+e));this.setLength(this._length-e)}removeByMask(t,e=!0){if(this._length!=t.length)throw new Error("length != mask.length");if(t==this)this.setLength(t.countBits(!e)),this.setAll(!e);else{let n=0;for(let i=-1;-1!=(i=t.findNext(i,!e));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(t){return!!(this._data[Math.floor(t/32)]&1<<(31&t))}setBit(t,e,n=!0){this.setFast(t,e),this._version++}setFast(t,e){e?this._data[Math.floor(t/32)]|=1<<(31&t):this._data[Math.floor(t/32)]&=~(1<<(31&t))}setTrue(t){this._data[Math.floor(t/32)]|=1<<(31&t)}setFalse(t){this._data[Math.floor(t/32)]&=~(1<<(31&t))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(t){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const t=this.lengthInInts;let e=0;for(;e<t-1;e++)for(let t=this._data[e];0!=t;t>>>=8)this._selectedCount+=i._onBitCount[255&t];let n=this._data[e];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return t?this._selectedCount:this._length-this._selectedCount}countWhere(t){let e=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)e+=t(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)e+=t(n)?1:0;return e}andWithCountBits(t,e){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let o=0;for(;o<r-1;o++)for(let e=this._data[o]&t._data[o];0!=e;e>>>=8)n+=i._onBitCount[255&e];let s=this._data[o]&t._data[o];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return e?n:this._length-n}clear(){this.setLength(0)}contains(t){return this.findNext(-1,t)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(t,e=!0){if(this.assureInRange(t,-1,this._length,"index"),t>=this._length-1)return-1;let n=31&(t=t<0?0:t+1);const r=this.lengthInInts;for(let o=Math.floor(t/32);o<r;o++){let r=e?this._data[o]:~this._data[o];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!e&&-4294967296==r)continue;for(let e=0;0!=r;e+=8,r>>>=8){const n=i._firstOnBit[255&r];if(n>=0)return(t=n+32*o+e)>=this._length?-1:t}}return-1}findPrev(t,e=!0){if(0==t)return-1;this.assureInRange(t,-1,this._length,"index");let n=1+(t=t<0?this._length-1:t-1)&31;for(let r=Math.floor(t/32);r>=0;r--){let t=e?this._data[r]:~this._data[r];0!=n&&(t&=~(4294967295<<n),n=0);for(let e=24;0!=t;e-=8,t<<=8){const n=i._lastOnBit[t>>>24];if(n>=0)return n+32*r+e}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(t,e,n)=>{"use strict";n.d(e,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,o=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function s(t,e,n,i=0,r="timeout"){return o(this,void 0,void 0,(function*(){return new Promise(((o,s)=>{const a=t.subscribe((t=>{try{e(t),o("OK")}catch(t){s(t)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(r)}),i);n()}))}))}function a(t){return o(this,void 0,void 0,(function*(){yield new Promise((e=>setTimeout(e,t)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(t){t.notNull=function(t,e){if(null==t)throw new Error(`${null==e?"Value":e} not defined`)}}(r||(r={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3527:(t,e,n)=>{"use strict";n.d(e,{Mi:()=>i});class i extends Float32Array{}},3629:(t,e,n)=>{"use strict";n.d(e,{KE:()=>a,S8:()=>l,dC:()=>o,vA:()=>r,wQ:()=>s});var i=n(3527);function r(t=!1,e="Assertion error."){if(!t)throw new Error(e)}function o(t,e,n=1){const o=t.length;r(o==e.length,"Vector lengths do not match.");const s=new i.Mi(o);for(let i=0;i<t.length;++i)s[i]=t[i]+n*e[i];return s}function s(t){let e=0;for(let n=0;n<t.length;n++)e+=t[n]*t[n];return Math.sqrt(e)}function a(t,e){if(t.length!=e.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<t.length;i++)n+=t[i]*e[i];return n}function l(t){const e=t.length;let n=0,i=0;for(let r=0;r<e;++r)n+=t[r],i+=Math.pow(t[r],2);const r=n/e,o=1/Math.sqrt(i/e-Math.pow(r,2));for(let n=0;n<e;++n)t[n]=(t[n]-r)*o;return t}},1913:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3282),r=n(9029),o=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",h=new i.Name("emUsed"),u={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(t,e={})=>{if(!t.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(t.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return t.addKeyword(function(t){return{keyword:c,schemaType:["string","object"],post:!0,code(e){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=e;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(t,e){return r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath === ${w}`,i._`${t}.keyword in ${e}`,i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${t}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(t,e){const i=[];for(const n in t){const t=e[n];d.test(t)&&i.push([n,x(t)])}return n.object(...i)}function S(t){return d.test(t)?new o._Code(o.safeStringify(t).replace(p,((t,e)=>`" + JSON.stringify(${s.getData(e,b)}) + "`)).replace(m,"")):i.stringify(t)}function x(t){return i._`function(){return ${S(t)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[o,s]=function(t){let e,n;for(const i in t){if("properties"===i||"items"===i)continue;const r=t[i];if("object"==typeof r){e||(e={});const t=e[i]={};for(const e in r)t[e]=[]}else n||(n={}),n[i]=[]}return[e,n]}(v);s&&function(r){const o=n.const("emErrors",i.stringify(r)),s=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(t=>n.if(C(t,o),(()=>n.code(i._`${o}[${t}.keyword].push(${t})`).assign(i._`${t}.${h}`,!0)))));const{singleError:c}=t;if(c){const t=n.let("message",i._`""`),r=n.let("paramsErrors",i._`[]`);u((e=>{n.if(t,(()=>n.code(i._`${t} += ${"string"==typeof c?c:";"}`))),n.code(i._`${t} += ${d(e)}`),n.assign(r,i._`${r}.concat(${o}[${e}])`)})),a.reportError(e,{message:t,params:i._`{errors: ${r}}`})}else u((t=>a.reportError(e,{message:d(t),params:i._`{errors: ${o}[${t}]}`})));function u(t){n.forIn("key",o,(e=>n.if(i._`${o}[${e}].length`,(()=>t(e)))))}function d(t){return i._`${t} in ${s} ? ${s}[${t}]() : ${y}[${t}]`}}(s),o&&function(t){const r=n.const("emErrors",i.stringify(t)),o=[];for(const e in t)o.push([e,A(t[e],g[e])]);const s=n.const("templates",n.object(...o)),c=n.scopeValue("obj",{ref:u,code:i.stringify(u)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(t=>n.if(C(t,r),(()=>{n.assign(d,i._`${c}[${t}.keyword]`),n.assign(p,i._`${r}[${t}.keyword][${t}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${t})`).assign(i._`${t}.${h}`,!0)))})))),n.forIn("key",r,(t=>n.forIn("keyProp",i._`${r}[${t}]`,(o=>{n.assign(p,i._`${r}[${t}][${o}]`),n.if(i._`${p}.length`,(()=>{const r=n.const("tmpl",i._`${s}[${t}] && ${s}[${t}][${o}]`);a.reportError(e,{message:i._`${r} ? ${r}() : ${y}[${t}][${o}]`,params:i._`{errors: ${p}}`})}))}))))}(o),function(t){const{props:o,items:s}=t;if(!o&&!s)return;const u=i._`typeof ${f} == "object"`,d=i._`Array.isArray(${f})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(t,e){n.assign(p,i.stringify(t)),n.assign(v,A(t,e))}o&&s?(m=n.let("emChildKwd"),n.if(u),n.if(d,(()=>{C(s,g.items),n.assign(m,i.str`items`)}),(()=>{C(o,g.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,g.items),b=i._`.items`):o&&(n.if(r.and(u,r.not(d))),C(o,g.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(t=>function(t,e,o){n.if(r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,i._`${t}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${r}.exec(${t}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${e}`,(()=>o(a)))}))}(t,p,(e=>n.code(i._`${p}[${e}].push(${t})`).assign(i._`${t}.${h}`,!0))))),n.forIn("key",p,(t=>n.if(i._`${p}[${t}].length`,(()=>{a.reportError(e,{message:i._`${t} in ${v} ? ${v}[${t}]() : ${y}${b}[${t}]`,params:i._`{errors: ${p}[${t}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:t,items:e}){const n={};if(t){n.props={};for(const e in t)n.props[e]=[]}if(e){n.items={};for(let t=0;t<e.length;t++)n.items[t]=[]}return n}(v))}const o="string"==typeof v?v:v._;o&&function(t){const o=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(function(t){return r.and(i._`${t}.keyword !== ${c}`,i._`!${t}.${h}`,r.or(i._`${t}.instancePath === ${w}`,r.and(i._`${t}.instancePath.indexOf(${w}) === 0`,i._`${t}.instancePath[${w}.length] === "/"`)),i._`${t}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${t}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(t),(()=>n.code(i._`${o}.push(${t})`).assign(i._`${t}.${h}`,!0))))),n.if(i._`${o}.length`,(()=>a.reportError(e,{message:S(t),params:i._`{errors: ${o}}`})))}(o),t.keepErrors||function(){const t=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(i._`!${e}.${h}`,(()=>n.code(i._`${t}.push(${e})`))))),n.assign(l.default.vErrors,t).assign(l.default.errors,i._`${t}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(e))};e.default=f,t.exports=f,t.exports.default=f},7433:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv2020=void 0;const i=n(4042),r=n(6105),o=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(t={}){super({...t,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:t,meta:e}=this.opts;e&&(s.default.call(this,t),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}e.Ajv2020=l,t.exports=e=l,t.exports.Ajv2020=l,Object.defineProperty(e,"__esModule",{value:!0}),e.default=l;var c=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var h=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var u=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return u.default}});var d=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.MissingRefError=e.ValidationError=e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=e.Ajv=void 0;const i=n(4042),r=n(6144),o=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((t=>this.addVocabulary(t))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const t=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(t,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}e.Ajv=c,t.exports=e=c,t.exports.Ajv=c,Object.defineProperty(e,"__esModule",{value:!0}),e.default=c;var h=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return h.KeywordCxt}});var u=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var d=n(3558);Object.defineProperty(e,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(e,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.regexpCode=e.getEsmExportName=e.getProperty=e.safeStringify=e.stringify=e.strConcat=e.addCodeArg=e.str=e._=e.nil=e._Code=e.Name=e.IDENTIFIER=e._CodeOrName=void 0;class n{}e._CodeOrName=n,e.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(t){if(super(),!e.IDENTIFIER.test(t))throw new Error("CodeGen: name must be a valid identifier");this.str=t}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}e.Name=i;class r extends n{constructor(t){super(),this._items="string"==typeof t?[t]:t}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const t=this._items[0];return""===t||'""'===t}get str(){var t;return null!==(t=this._str)&&void 0!==t?t:this._str=this._items.reduce(((t,e)=>`${t}${e}`),"")}get names(){var t;return null!==(t=this._names)&&void 0!==t?t:this._names=this._items.reduce(((t,e)=>(e instanceof i&&(t[e.str]=(t[e.str]||0)+1),t)),{})}}function o(t,...e){const n=[t[0]];let i=0;for(;i<e.length;)l(n,e[i]),n.push(t[++i]);return new r(n)}e._Code=r,e.nil=new r(""),e._=o;const s=new r("+");function a(t,...e){const n=[h(t[0])];let i=0;for(;i<e.length;)n.push(s),l(n,e[i]),n.push(s,h(t[++i]));return function(t){let e=1;for(;e<t.length-1;){if(t[e]===s){const n=c(t[e-1],t[e+1]);if(void 0!==n){t.splice(e-1,3,n);continue}t[e++]="+"}e++}}(n),new r(n)}function l(t,e){var n;e instanceof r?t.push(...e._items):e instanceof i?t.push(e):t.push("number"==typeof(n=e)||"boolean"==typeof n||null===n?n:h(Array.isArray(n)?n.join(","):n))}function c(t,e){if('""'===e)return t;if('""'===t)return e;if("string"==typeof t){if(e instanceof i||'"'!==t[t.length-1])return;return"string"!=typeof e?`${t.slice(0,-1)}${e}"`:'"'===e[0]?t.slice(0,-1)+e.slice(1):void 0}return"string"!=typeof e||'"'!==e[0]||t instanceof i?void 0:`"${t}${e.slice(1)}`}function h(t){return JSON.stringify(t).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}e.str=a,e.addCodeArg=l,e.strConcat=function(t,e){return e.emptyStr()?t:t.emptyStr()?e:a`${t}${e}`},e.stringify=function(t){return new r(h(t))},e.safeStringify=h,e.getProperty=function(t){return"string"==typeof t&&e.IDENTIFIER.test(t)?new r(`.${t}`):o`[${t}]`},e.getEsmExportName=function(t){if("string"==typeof t&&e.IDENTIFIER.test(t))return new r(`${t}`);throw new Error(`CodeGen: invalid export name: ${t}, use explicit $id name mapping`)},e.regexpCode=function(t){return new r(t.toString())}},9029:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.or=e.and=e.not=e.CodeGen=e.operators=e.varKinds=e.ValueScopeName=e.ValueScope=e.Scope=e.Name=e.regexpCode=e.stringify=e.getProperty=e.nil=e.strConcat=e.str=e._=void 0;const i=n(1520),r=n(7845);var o=n(1520);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(e,"strConcat",{enumerable:!0,get:function(){return o.strConcat}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(e,"getProperty",{enumerable:!0,get:function(){return o.getProperty}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(e,"regexpCode",{enumerable:!0,get:function(){return o.regexpCode}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return o.Name}});var s=n(7845);Object.defineProperty(e,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(e,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(e,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(e,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),e.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(t,e){return this}}class l extends a{constructor(t,e,n){super(),this.varKind=t,this.name=e,this.rhs=n}render({es5:t,_n:e}){const n=t?r.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+e}optimizeNames(t,e){if(t[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,t,e)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(t,e,n){super(),this.lhs=t,this.rhs=e,this.sideEffects=n}render({_n:t}){return`${this.lhs} = ${this.rhs};`+t}optimizeNames(t,e){if(!(this.lhs instanceof i.Name)||t[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,t,e),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class h extends c{constructor(t,e,n,i){super(t,n,i),this.op=e}render({_n:t}){return`${this.lhs} ${this.op}= ${this.rhs};`+t}}class u extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`${this.label}:`+t}}class d extends a{constructor(t){super(),this.label=t,this.names={}}render({_n:t}){return`break${this.label?` ${this.label}`:""};`+t}}class p extends a{constructor(t){super(),this.error=t}render({_n:t}){return`throw ${this.error};`+t}get names(){return this.error.names}}class m extends a{constructor(t){super(),this.code=t}render({_n:t}){return`${this.code};`+t}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(t,e){return this.code=N(this.code,t,e),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class f extends a{constructor(t=[]){super(),this.nodes=t}render(t){return this.nodes.reduce(((e,n)=>e+n.render(t)),"")}optimizeNodes(){const{nodes:t}=this;let e=t.length;for(;e--;){const n=t[e].optimizeNodes();Array.isArray(n)?t.splice(e,1,...n):n?t[e]=n:t.splice(e,1)}return t.length>0?this:void 0}optimizeNames(t,e){const{nodes:n}=this;let i=n.length;for(;i--;){const r=n[i];r.optimizeNames(t,e)||(P(t,r.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((t,e)=>T(t,e.names)),{})}}class g extends f{render(t){return"{"+t._n+super.render(t)+"}"+t._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(t,e){super(e),this.condition=t}render(t){let e=`if(${this.condition})`+super.render(t);return this.else&&(e+="else "+this.else.render(t)),e}optimizeNodes(){super.optimizeNodes();const t=this.condition;if(!0===t)return this.nodes;let e=this.else;if(e){const t=e.optimizeNodes();e=this.else=Array.isArray(t)?new b(t):t}return e?!1===t?e instanceof v?e:e.nodes:this.nodes.length?this:new v($(t),e instanceof v?[e]:e.nodes):!1!==t&&this.nodes.length?this:void 0}optimizeNames(t,e){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(t,e),super.optimizeNames(t,e)||this.else)return this.condition=N(this.condition,t,e),this}get names(){const t=super.names;return L(t,this.condition),this.else&&T(t,this.else.names),t}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(t){super(),this.iteration=t}render(t){return`for(${this.iteration})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iteration=N(this.iteration,t,e),this}get names(){return T(super.names,this.iteration.names)}}class A extends w{constructor(t,e,n,i){super(),this.varKind=t,this.name=e,this.from=n,this.to=i}render(t){const e=t.es5?r.varKinds.var:this.varKind,{name:n,from:i,to:o}=this;return`for(${e} ${n}=${i}; ${n}<${o}; ${n}++)`+super.render(t)}get names(){const t=L(super.names,this.from);return L(t,this.to)}}class S extends w{constructor(t,e,n,i){super(),this.loop=t,this.varKind=e,this.name=n,this.iterable=i}render(t){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(t)}optimizeNames(t,e){if(super.optimizeNames(t,e))return this.iterable=N(this.iterable,t,e),this}get names(){return T(super.names,this.iterable.names)}}class x extends g{constructor(t,e,n){super(),this.name=t,this.args=e,this.async=n}render(t){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(t)}}x.kind="func";class E extends f{render(t){return"return "+super.render(t)}}E.kind="return";class M extends g{render(t){let e="try"+super.render(t);return this.catch&&(e+=this.catch.render(t)),this.finally&&(e+=this.finally.render(t)),e}optimizeNodes(){var t,e;return super.optimizeNodes(),null===(t=this.catch)||void 0===t||t.optimizeNodes(),null===(e=this.finally)||void 0===e||e.optimizeNodes(),this}optimizeNames(t,e){var n,i;return super.optimizeNames(t,e),null===(n=this.catch)||void 0===n||n.optimizeNames(t,e),null===(i=this.finally)||void 0===i||i.optimizeNames(t,e),this}get names(){const t=super.names;return this.catch&&T(t,this.catch.names),this.finally&&T(t,this.finally.names),t}}class _ extends g{constructor(t){super(),this.error=t}render(t){return`catch(${this.error})`+super.render(t)}}_.kind="catch";class I extends g{render(t){return"finally"+super.render(t)}}function T(t,e){for(const n in e)t[n]=(t[n]||0)+(e[n]||0);return t}function L(t,e){return e instanceof i._CodeOrName?T(t,e.names):t}function N(t,e,n){return t instanceof i.Name?o(t):(r=t)instanceof i._Code&&r._items.some((t=>t instanceof i.Name&&1===e[t.str]&&void 0!==n[t.str]))?new i._Code(t._items.reduce(((t,e)=>(e instanceof i.Name&&(e=o(e)),e instanceof i._Code?t.push(...e._items):t.push(e),t)),[])):t;var r;function o(t){const i=n[t.str];return void 0===i||1!==e[t.str]?t:(delete e[t.str],i)}}function P(t,e){for(const n in e)t[n]=(t[n]||0)-(e[n]||0)}function $(t){return"boolean"==typeof t||"number"==typeof t||null===t?!t:i._`!${G(t)}`}I.kind="finally",e.CodeGen=class{constructor(t,e={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...e,_n:e.lines?"\n":""},this._extScope=t,this._scope=new r.Scope({parent:t}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(t){return this._scope.name(t)}scopeName(t){return this._extScope.name(t)}scopeValue(t,e){const n=this._extScope.value(t,e);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(t,e){return this._extScope.getValue(t,e)}scopeRefs(t){return this._extScope.scopeRefs(t,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(t,e,n,i){const r=this._scope.toName(e);return void 0!==n&&i&&(this._constants[r.str]=n),this._leafNode(new l(t,r,n)),r}const(t,e,n){return this._def(r.varKinds.const,t,e,n)}let(t,e,n){return this._def(r.varKinds.let,t,e,n)}var(t,e,n){return this._def(r.varKinds.var,t,e,n)}assign(t,e,n){return this._leafNode(new c(t,e,n))}add(t,n){return this._leafNode(new h(t,e.operators.ADD,n))}code(t){return"function"==typeof t?t():t!==i.nil&&this._leafNode(new m(t)),this}object(...t){const e=["{"];for(const[n,r]of t)e.length>1&&e.push(","),e.push(n),(n!==r||this.opts.es5)&&(e.push(":"),(0,i.addCodeArg)(e,r));return e.push("}"),new i._Code(e)}if(t,e,n){if(this._blockNode(new v(t)),e&&n)this.code(e).else().code(n).endIf();else if(e)this.code(e).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(t){return this._elseNode(new v(t))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(t,e){return this._blockNode(t),e&&this.code(e).endFor(),this}for(t,e){return this._for(new C(t),e)}forRange(t,e,n,i,o=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const s=this._scope.toName(t);return this._for(new A(o,s,e,n),(()=>i(s)))}forOf(t,e,n,o=r.varKinds.const){const s=this._scope.toName(t);if(this.opts.es5){const t=e instanceof i.Name?e:this.var("_arr",e);return this.forRange("_i",0,i._`${t}.length`,(e=>{this.var(s,i._`${t}[${e}]`),n(s)}))}return this._for(new S("of",o,s,e),(()=>n(s)))}forIn(t,e,n,o=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(t,i._`Object.keys(${e})`,n);const s=this._scope.toName(t);return this._for(new S("in",o,s,e),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(t){return this._leafNode(new u(t))}break(t){return this._leafNode(new d(t))}return(t){const e=new E;if(this._blockNode(e),this.code(t),1!==e.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(t,e,n){if(!e&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new M;if(this._blockNode(i),this.code(t),e){const t=this.name("e");this._currNode=i.catch=new _(t),e(t)}return n&&(this._currNode=i.finally=new I,this.code(n)),this._endBlockNode(_,I)}throw(t){return this._leafNode(new p(t))}block(t,e){return this._blockStarts.push(this._nodes.length),t&&this.code(t).endBlock(e),this}endBlock(t){const e=this._blockStarts.pop();if(void 0===e)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-e;if(n<0||void 0!==t&&n!==t)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${t} expected`);return this._nodes.length=e,this}func(t,e=i.nil,n,r){return this._blockNode(new x(t,e,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(t=1){for(;t-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(t){return this._currNode.nodes.push(t),this}_blockNode(t){this._currNode.nodes.push(t),this._nodes.push(t)}_endBlockNode(t,e){const n=this._currNode;if(n instanceof t||e&&n instanceof e)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${e?`${t.kind}/${e.kind}`:t.kind}"`)}_elseNode(t){const e=this._currNode;if(!(e instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=e.else=t,this}get _root(){return this._nodes[0]}get _currNode(){const t=this._nodes;return t[t.length-1]}set _currNode(t){const e=this._nodes;e[e.length-1]=t}},e.not=$;const R=k(e.operators.AND);e.and=function(...t){return t.reduce(R)};const O=k(e.operators.OR);function k(t){return(e,n)=>e===i.nil?n:n===i.nil?e:i._`${G(e)} ${t} ${G(n)}`}function G(t){return t instanceof i.Name?t:i._`(${t})`}e.or=function(...t){return t.reduce(O)}},7845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.ValueScope=e.ValueScopeName=e.Scope=e.varKinds=e.UsedValueState=void 0;const i=n(1520);class r extends Error{constructor(t){super(`CodeGen: "code" for ${t} not defined`),this.value=t.value}}var o;!function(t){t[t.Started=0]="Started",t[t.Completed=1]="Completed"}(o||(e.UsedValueState=o={})),e.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:t,parent:e}={}){this._names={},this._prefixes=t,this._parent=e}toName(t){return t instanceof i.Name?t:this.name(t)}name(t){return new i.Name(this._newName(t))}_newName(t){return`${t}${(this._names[t]||this._nameGroup(t)).index++}`}_nameGroup(t){var e,n;if((null===(n=null===(e=this._parent)||void 0===e?void 0:e._prefixes)||void 0===n?void 0:n.has(t))||this._prefixes&&!this._prefixes.has(t))throw new Error(`CodeGen: prefix "${t}" is not allowed in this scope`);return this._names[t]={prefix:t,index:0}}}e.Scope=s;class a extends i.Name{constructor(t,e){super(e),this.prefix=t}setValue(t,{property:e,itemIndex:n}){this.value=t,this.scopePath=i._`.${new i.Name(e)}[${n}]`}}e.ValueScopeName=a;const l=i._`\n`;e.ValueScope=class extends s{constructor(t){super(t),this._values={},this._scope=t.scope,this.opts={...t,_n:t.lines?l:i.nil}}get(){return this._scope}name(t){return new a(t,this._newName(t))}value(t,e){var n;if(void 0===e.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(t),{prefix:r}=i,o=null!==(n=e.key)&&void 0!==n?n:e.ref;let s=this._values[r];if(s){const t=s.get(o);if(t)return t}else s=this._values[r]=new Map;s.set(o,i);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=e.ref,i.setValue(e,{property:r,itemIndex:l}),i}getValue(t,e){const n=this._values[t];if(n)return n.get(e)}scopeRefs(t,e=this._values){return this._reduceValues(e,(e=>{if(void 0===e.scopePath)throw new Error(`CodeGen: name "${e}" has no value`);return i._`${t}${e.scopePath}`}))}scopeCode(t=this._values,e,n){return this._reduceValues(t,(t=>{if(void 0===t.value)throw new Error(`CodeGen: name "${t}" has no value`);return t.value.code}),e,n)}_reduceValues(t,n,s={},a){let l=i.nil;for(const c in t){const h=t[c];if(!h)continue;const u=s[c]=s[c]||new Map;h.forEach((t=>{if(u.has(t))return;u.set(t,o.Started);let s=n(t);if(s){const n=this.opts.es5?e.varKinds.var:e.varKinds.const;l=i._`${l}${n} ${t} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(t)))throw new r(t);l=i._`${l}${s}${this.opts._n}`}u.set(t,o.Completed)}))}return l}}},8708:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.extendErrors=e.resetErrorsCount=e.reportExtraError=e.reportError=e.keyword$DataError=e.keywordError=void 0;const i=n(9029),r=n(4227),o=n(2023);function s(t,e){const n=t.const("err",e);t.if(i._`${o.default.vErrors} === null`,(()=>t.assign(o.default.vErrors,i._`[${n}]`)),i._`${o.default.vErrors}.push(${n})`),t.code(i._`${o.default.errors}++`)}function a(t,e){const{gen:n,validateName:r,schemaEnv:o}=t;o.$async?n.throw(i._`new ${t.ValidationError}(${e})`):(n.assign(i._`${r}.errors`,e),n.return(!1))}e.keywordError={message:({keyword:t})=>i.str`must pass "${t}" keyword validation`},e.keyword$DataError={message:({keyword:t,schemaType:e})=>e?i.str`"${t}" keyword must be ${e} ($data)`:i.str`"${t}" keyword is invalid ($data)`},e.reportError=function(t,n=e.keywordError,r,o){const{it:l}=t,{gen:h,compositeRule:u,allErrors:d}=l,p=c(t,n,r);(null!=o?o:u||d)?s(h,p):a(l,i._`[${p}]`)},e.reportExtraError=function(t,n=e.keywordError,i){const{it:r}=t,{gen:l,compositeRule:h,allErrors:u}=r;s(l,c(t,n,i)),h||u||a(r,o.default.vErrors)},e.resetErrorsCount=function(t,e){t.assign(o.default.errors,e),t.if(i._`${o.default.vErrors} !== null`,(()=>t.if(e,(()=>t.assign(i._`${o.default.vErrors}.length`,e)),(()=>t.assign(o.default.vErrors,null)))))},e.extendErrors=function({gen:t,keyword:e,schemaValue:n,data:r,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=t.name("err");t.forRange("i",s,o.default.errors,(s=>{t.const(l,i._`${o.default.vErrors}[${s}]`),t.if(i._`${l}.instancePath === undefined`,(()=>t.assign(i._`${l}.instancePath`,(0,i.strConcat)(o.default.instancePath,a.errorPath)))),t.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${e}`),a.opts.verbose&&(t.assign(i._`${l}.schema`,n),t.assign(i._`${l}.data`,r))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(t,e,n){const{createErrors:r}=t.it;return!1===r?i._`{}`:function(t,e,n={}){const{gen:r,it:s}=t,a=[h(s,n),u(t,n)];return function(t,{params:e,message:n},r){const{keyword:s,data:a,schemaValue:c,it:h}=t,{opts:u,propertyName:d,topSchemaRef:p,schemaPath:m}=h;r.push([l.keyword,s],[l.params,"function"==typeof e?e(t):e||i._`{}`]),u.messages&&r.push([l.message,"function"==typeof n?n(t):n]),u.verbose&&r.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[o.default.data,a]),d&&r.push([l.propertyName,d])}(t,e,a),r.object(...a)}(t,e,n)}function h({errorPath:t},{instancePath:e}){const n=e?i.str`${t}${(0,r.getErrorPath)(e,r.Type.Str)}`:t;return[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,n)]}function u({keyword:t,it:{errSchemaPath:e}},{schemaPath:n,parentSchema:o}){let s=o?e:i.str`${e}/${t}`;return n&&(s=i.str`${s}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,s]}},3835:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.resolveSchema=e.getCompilingSchema=e.resolveRef=e.compileSchema=e.SchemaEnv=void 0;const i=n(9029),r=n(3558),o=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(t){var e;let n;this.refs={},this.dynamicAnchors={},"object"==typeof t.schema&&(n=t.schema),this.schema=t.schema,this.schemaId=t.schemaId,this.root=t.root||this,this.baseId=null!==(e=t.baseId)&&void 0!==e?e:(0,s.normalizeId)(null==n?void 0:n[t.schemaId||"$id"]),this.schemaPath=t.schemaPath,this.localRefs=t.localRefs,this.meta=t.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function h(t){const e=d.call(this,t);if(e)return e;const n=(0,s.getFullPath)(this.opts.uriResolver,t.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:h}=this.opts,u=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:h});let p;t.$async&&(p=u.scopeValue("Error",{ref:r.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=u.scopeName("validate");t.validateName=m;const f={gen:u,allErrors:this.opts.allErrors,data:o.default.data,parentData:o.default.parentData,parentDataProperty:o.default.parentDataProperty,dataNames:[o.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:u.scopeValue("schema",!0===this.opts.code.source?{ref:t.schema,code:(0,i.stringify)(t.schema)}:{ref:t.schema}),validateName:m,ValidationError:p,schema:t.schema,schemaEnv:t,rootId:n,baseId:t.baseId||n,schemaPath:i.nil,errSchemaPath:t.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(t),(0,l.validateFunctionCode)(f),u.optimize(this.opts.code.optimize);const e=u.toString();g=`${u.scopeRefs(o.default.scope)}return ${e}`,this.opts.code.process&&(g=this.opts.code.process(g,t));const n=new Function(`${o.default.self}`,`${o.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=t.schema,n.schemaEnv=t,t.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:e,scopeValues:u._values}),this.opts.unevaluated){const{props:t,items:e}=f;n.evaluated={props:t instanceof i.Name?void 0:t,items:e instanceof i.Name?void 0:e,dynamicProps:t instanceof i.Name,dynamicItems:e instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return t.validate=n,t}catch(e){throw delete t.validate,delete t.validateName,g&&this.logger.error("Error compiling schema, function code:",g),e}finally{this._compilations.delete(t)}}function u(t){return(0,s.inlineRef)(t.schema,this.opts.inlineRefs)?t.schema:t.validate?t:h.call(this,t)}function d(t){for(const i of this._compilations)if(n=t,(e=i).schema===n.schema&&e.root===n.root&&e.baseId===n.baseId)return i;var e,n}function p(t,e){let n;for(;"string"==typeof(n=this.refs[e]);)e=n;return n||this.schemas[e]||m.call(this,t,e)}function m(t,e){const n=this.opts.uriResolver.parse(e),i=(0,s._getFullPath)(this.opts.uriResolver,n);let r=(0,s.getFullPath)(this.opts.uriResolver,t.baseId,void 0);if(Object.keys(t.schema).length>0&&i===r)return g.call(this,n,t);const o=(0,s.normalizeId)(i),a=this.refs[o]||this.schemas[o];if("string"==typeof a){const e=m.call(this,t,a);if("object"!=typeof(null==e?void 0:e.schema))return;return g.call(this,n,e)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||h.call(this,a),o===(0,s.normalizeId)(e)){const{schema:e}=a,{schemaId:n}=this.opts,i=e[n];return i&&(r=(0,s.resolveUrl)(this.opts.uriResolver,r,i)),new c({schema:e,schemaId:n,root:t,baseId:r})}return g.call(this,n,a)}}e.SchemaEnv=c,e.compileSchema=h,e.resolveRef=function(t,e,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,e,n);const r=t.refs[n];if(r)return r;let o=p.call(this,t,n);if(void 0===o){const r=null===(i=t.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;r&&(o=new c({schema:r,schemaId:s,root:t,baseId:e}))}return void 0!==o?t.refs[n]=u.call(this,o):void 0},e.getCompilingSchema=d,e.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(t,{baseId:e,schema:n,root:i}){var r;if("/"!==(null===(r=t.fragment)||void 0===r?void 0:r[0]))return;for(const i of t.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const t=n[(0,a.unescapeFragment)(i)];if(void 0===t)return;const r="object"==typeof(n=t)&&n[this.opts.schemaId];!f.has(i)&&r&&(e=(0,s.resolveUrl)(this.opts.uriResolver,e,r))}let o;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const t=(0,s.resolveUrl)(this.opts.uriResolver,e,n.$ref);o=m.call(this,i,t)}const{schemaId:l}=this.opts;return o=o||new c({schema:n,schemaId:l,root:i,baseId:e}),o.schema!==o.root.schema?o:void 0}},2023:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};e.default=r},4551:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(6939);class r extends Error{constructor(t,e,n,r){super(r||`can't resolve reference ${n} from id ${e}`),this.missingRef=(0,i.resolveUrl)(t,e,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(t,this.missingRef))}}e.default=r},6939:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getSchemaRefs=e.resolveUrl=e.normalizeId=e._getFullPath=e.getFullPath=e.inlineRef=void 0;const i=n(4227),r=n(2017),o=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);e.inlineRef=function(t,e=!0){return"boolean"==typeof t||(!0===e?!l(t):!!e&&c(t)<=e)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(t){for(const e in t){if(a.has(e))return!0;const n=t[e];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(t){let e=0;for(const n in t){if("$ref"===n)return 1/0;if(e++,!s.has(n)&&("object"==typeof t[n]&&(0,i.eachItem)(t[n],(t=>e+=c(t))),e===1/0))return 1/0}return e}function h(t,e="",n){!1!==n&&(e=p(e));const i=t.parse(e);return u(t,i)}function u(t,e){return t.serialize(e).split("#")[0]+"#"}e.getFullPath=h,e._getFullPath=u;const d=/#\/?$/;function p(t){return t?t.replace(d,""):""}e.normalizeId=p,e.resolveUrl=function(t,e,n){return n=p(n),t.resolve(e,n)};const m=/^[a-z_][-a-z0-9._]*$/i;e.getSchemaRefs=function(t,e){if("boolean"==typeof t)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(t[n]||e),a={"":s},l=h(i,s,!1),c={},u=new Set;return o(t,{allKeys:!0},((t,e,i,r)=>{if(void 0===r)return;const o=l+e;let s=a[r];function h(e){const n=this.opts.uriResolver.resolve;if(e=p(s?n(s,e):e),u.has(e))throw f(e);u.add(e);let i=this.refs[e];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(t,i.schema,e):e!==p(o)&&("#"===e[0]?(d(t,c[e],e),c[e]=t):this.refs[e]=o),e}function g(t){if("string"==typeof t){if(!m.test(t))throw new Error(`invalid anchor "${t}"`);h.call(this,`#${t}`)}}"string"==typeof t[n]&&(s=h.call(this,t[n])),g.call(this,t.$anchor),g.call(this,t.$dynamicAnchor),a[e]=s})),c;function d(t,e,n){if(void 0!==e&&!r(t,e))throw f(n)}function f(t){return new Error(`reference "${t}" resolves to more than one schema`)}}},396:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getRules=e.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);e.isJSONType=function(t){return"string"==typeof t&&n.has(t)},e.getRules=function(){const t={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...t,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},t.number,t.string,t.array,t.object],post:{rules:[]},all:{},keywords:{}}}},4227:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.checkStrictMode=e.getErrorPath=e.Type=e.useFunc=e.setEvaluated=e.evaluatedPropsToName=e.mergeEvaluated=e.eachItem=e.unescapeJsonPointer=e.escapeJsonPointer=e.escapeFragment=e.unescapeFragment=e.schemaRefOrVal=e.schemaHasRulesButRef=e.schemaHasRules=e.checkUnknownRules=e.alwaysValidSchema=e.toHash=void 0;const i=n(9029),r=n(1520);function o(t,e=t.schema){const{opts:n,self:i}=t;if(!n.strictSchema)return;if("boolean"==typeof e)return;const r=i.RULES.keywords;for(const n in e)r[n]||m(t,`unknown keyword: "${n}"`)}function s(t,e){if("boolean"==typeof t)return!t;for(const n in t)if(e[n])return!0;return!1}function a(t){return"number"==typeof t?`${t}`:t.replace(/~/g,"~0").replace(/\//g,"~1")}function l(t){return t.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:t,mergeToName:e,mergeValues:n,resultToName:r}){return(o,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?t(o,s,a):e(o,s,a),a):s instanceof i.Name?(e(o,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:r(o,c)}}function h(t,e){if(!0===e)return t.var("props",!0);const n=t.var("props",i._`{}`);return void 0!==e&&u(t,n,e),n}function u(t,e,n){Object.keys(n).forEach((n=>t.assign(i._`${e}${(0,i.getProperty)(n)}`,!0)))}e.toHash=function(t){const e={};for(const n of t)e[n]=!0;return e},e.alwaysValidSchema=function(t,e){return"boolean"==typeof e?e:0===Object.keys(e).length||(o(t,e),!s(e,t.self.RULES.all))},e.checkUnknownRules=o,e.schemaHasRules=s,e.schemaHasRulesButRef=function(t,e){if("boolean"==typeof t)return!t;for(const n in t)if("$ref"!==n&&e.all[n])return!0;return!1},e.schemaRefOrVal=function({topSchemaRef:t,schemaPath:e},n,r,o){if(!o){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${t}${e}${(0,i.getProperty)(r)}`},e.unescapeFragment=function(t){return l(decodeURIComponent(t))},e.escapeFragment=function(t){return encodeURIComponent(a(t))},e.escapeJsonPointer=a,e.unescapeJsonPointer=l,e.eachItem=function(t,e){if(Array.isArray(t))for(const n of t)e(n);else e(t)},e.mergeEvaluated={props:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>{t.if(i._`${e} === true`,(()=>t.assign(n,!0)),(()=>t.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${e})`)))})),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>{!0===e?t.assign(n,!0):(t.assign(n,i._`${n} || {}`),u(t,n,e))})),mergeValues:(t,e)=>!0===t||{...t,...e},resultToName:h}),items:c({mergeNames:(t,e,n)=>t.if(i._`${n} !== true && ${e} !== undefined`,(()=>t.assign(n,i._`${e} === true ? true : ${n} > ${e} ? ${n} : ${e}`))),mergeToName:(t,e,n)=>t.if(i._`${n} !== true`,(()=>t.assign(n,!0===e||i._`${n} > ${e} ? ${n} : ${e}`))),mergeValues:(t,e)=>!0===t||Math.max(t,e),resultToName:(t,e)=>t.var("items",e)})},e.evaluatedPropsToName=h,e.setEvaluated=u;const d={};var p;function m(t,e,n=t.opts.strictSchema){if(n){if(e=`strict mode: ${e}`,!0===n)throw new Error(e);t.self.logger.warn(e)}}e.useFunc=function(t,e){return t.scopeValue("func",{ref:e,code:d[e.code]||(d[e.code]=new r._Code(e.code))})},function(t){t[t.Num=0]="Num",t[t.Str=1]="Str"}(p||(e.Type=p={})),e.getErrorPath=function(t,e,n){if(t instanceof i.Name){const r=e===p.Num;return n?r?i._`"[" + ${t} + "]"`:i._`"['" + ${t} + "']"`:r?i._`"/" + ${t}`:i._`"/" + ${t}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(t).toString():"/"+a(t)},e.checkStrictMode=m},7887:(t,e)=>{"use strict";function n(t,e){return e.rules.some((e=>i(t,e)))}function i(t,e){var n;return void 0!==t[e.keyword]||(null===(n=e.definition.implements)||void 0===n?void 0:n.some((e=>void 0!==t[e])))}Object.defineProperty(e,"__esModule",{value:!0}),e.shouldUseRule=e.shouldUseGroup=e.schemaHasRulesForType=void 0,e.schemaHasRulesForType=function({schema:t,self:e},i){const r=e.RULES.types[i];return r&&!0!==r&&n(t,r)},e.shouldUseGroup=n,e.shouldUseRule=i},8727:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.boolOrEmptySchema=e.topBoolOrEmptySchema=void 0;const i=n(8708),r=n(9029),o=n(2023),s={message:"boolean schema is false"};function a(t,e){const{gen:n,data:r}=t,o={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:t};(0,i.reportError)(o,s,void 0,e)}e.topBoolOrEmptySchema=function(t){const{gen:e,schema:n,validateName:i}=t;!1===n?a(t,!1):"object"==typeof n&&!0===n.$async?e.return(o.default.data):(e.assign(r._`${i}.errors`,null),e.return(!0))},e.boolOrEmptySchema=function(t,e){const{gen:n,schema:i}=t;!1===i?(n.var(e,!1),a(t)):n.var(e,!0)}},208:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.reportTypeError=e.checkDataTypes=e.checkDataType=e.coerceAndCheckDataType=e.getJSONTypes=e.getSchemaTypes=e.DataType=void 0;const i=n(396),r=n(7887),o=n(8708),s=n(9029),a=n(4227);var l;function c(t){const e=Array.isArray(t)?t:t?[t]:[];if(e.every(i.isJSONType))return e;throw new Error("type must be JSONType or JSONType[]: "+e.join(","))}!function(t){t[t.Correct=0]="Correct",t[t.Wrong=1]="Wrong"}(l||(e.DataType=l={})),e.getSchemaTypes=function(t){const e=c(t.type);if(e.includes("null")){if(!1===t.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!e.length&&void 0!==t.nullable)throw new Error('"nullable" cannot be used without "type"');!0===t.nullable&&e.push("null")}return e},e.getJSONTypes=c,e.coerceAndCheckDataType=function(t,e){const{gen:n,data:i,opts:o}=t,a=function(t,e){return e?t.filter((t=>h.has(t)||"array"===e&&"array"===t)):[]}(e,o.coerceTypes),c=e.length>0&&!(0===a.length&&1===e.length&&(0,r.schemaHasRulesForType)(t,e[0]));if(c){const r=d(e,i,o.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(t,e,n){const{gen:i,data:r,opts:o}=t,a=i.let("dataType",s._`typeof ${r}`),l=i.let("coerced",s._`undefined`);"array"===o.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>i.assign(r,s._`${r}[0]`).assign(a,s._`typeof ${r}`).if(d(e,r,o.strictNumbers),(()=>i.assign(l,r))))),i.if(s._`${l} !== undefined`);for(const t of n)(h.has(t)||"array"===t&&"array"===o.coerceTypes)&&c(t);function c(t){switch(t){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${r}`).elseIf(s._`${r} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${r} === null
               || (${a} == "string" && ${r} && ${r} == +${r})`).assign(l,s._`+${r}`);case"integer":return void i.elseIf(s._`${a} === "boolean" || ${r} === null
               || (${a} === "string" && ${r} && ${r} == +${r} && !(${r} % 1))`).assign(l,s._`+${r}`);case"boolean":return void i.elseIf(s._`${r} === "false" || ${r} === 0 || ${r} === null`).assign(l,!1).elseIf(s._`${r} === "true" || ${r} === 1`).assign(l,!0);case"null":return i.elseIf(s._`${r} === "" || ${r} === 0 || ${r} === false`),void i.assign(l,null);case"array":i.elseIf(s._`${a} === "string" || ${a} === "number"
               || ${a} === "boolean" || ${r} === null`).assign(l,s._`[${r}]`)}}i.else(),m(t),i.endIf(),i.if(s._`${l} !== undefined`,(()=>{i.assign(r,l),function({gen:t,parentData:e,parentDataProperty:n},i){t.if(s._`${e} !== undefined`,(()=>t.assign(s._`${e}[${n}]`,i)))}(t,l)}))}(t,e,a):m(t)}))}return c};const h=new Set(["string","number","integer","boolean","null"]);function u(t,e,n,i=l.Correct){const r=i===l.Correct?s.operators.EQ:s.operators.NEQ;let o;switch(t){case"null":return s._`${e} ${r} null`;case"array":o=s._`Array.isArray(${e})`;break;case"object":o=s._`${e} && typeof ${e} == "object" && !Array.isArray(${e})`;break;case"integer":o=a(s._`!(${e} % 1) && !isNaN(${e})`);break;case"number":o=a();break;default:return s._`typeof ${e} ${r} ${t}`}return i===l.Correct?o:(0,s.not)(o);function a(t=s.nil){return(0,s.and)(s._`typeof ${e} == "number"`,t,n?s._`isFinite(${e})`:s.nil)}}function d(t,e,n,i){if(1===t.length)return u(t[0],e,n,i);let r;const o=(0,a.toHash)(t);if(o.array&&o.object){const t=s._`typeof ${e} != "object"`;r=o.null?t:s._`!${e} || ${t}`,delete o.null,delete o.array,delete o.object}else r=s.nil;o.number&&delete o.integer;for(const t in o)r=(0,s.and)(r,u(t,e,n,i));return r}e.checkDataType=u,e.checkDataTypes=d;const p={message:({schema:t})=>`must be ${t}`,params:({schema:t,schemaValue:e})=>"string"==typeof t?s._`{type: ${t}}`:s._`{type: ${e}}`};function m(t){const e=function(t){const{gen:e,data:n,schema:i}=t,r=(0,a.schemaRefOrVal)(t,i,"type");return{gen:e,keyword:"type",data:n,schema:i.type,schemaCode:r,schemaValue:r,parentSchema:i,params:{},it:t}}(t);(0,o.reportError)(e,p)}e.reportTypeError=m},7870:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.assignDefaults=void 0;const i=n(9029),r=n(4227);function o(t,e,n){const{gen:o,compositeRule:s,data:a,opts:l}=t;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(e)}`;if(s)return void(0,r.checkStrictMode)(t,`default is ignored for: ${c}`);let h=i._`${c} === undefined`;"empty"===l.useDefaults&&(h=i._`${h} || ${c} === null || ${c} === ""`),o.if(h,i._`${c} = ${(0,i.stringify)(n)}`)}e.assignDefaults=function(t,e){const{properties:n,items:i}=t.schema;if("object"===e&&n)for(const e in n)o(t,e,n[e].default);else"array"===e&&Array.isArray(i)&&i.forEach(((e,n)=>o(t,n,e.default)))}},2586:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.getData=e.KeywordCxt=e.validateFunctionCode=void 0;const i=n(8727),r=n(208),o=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),h=n(9029),u=n(2023),d=n(6939),p=n(4227),m=n(8708);function f({gen:t,validateName:e,schema:n,schemaEnv:i,opts:r},o){r.code.es5?t.func(e,h._`${u.default.data}, ${u.default.valCxt}`,i.$async,(()=>{t.code(h._`"use strict"; ${g(n,r)}`),function(t,e){t.if(u.default.valCxt,(()=>{t.var(u.default.instancePath,h._`${u.default.valCxt}.${u.default.instancePath}`),t.var(u.default.parentData,h._`${u.default.valCxt}.${u.default.parentData}`),t.var(u.default.parentDataProperty,h._`${u.default.valCxt}.${u.default.parentDataProperty}`),t.var(u.default.rootData,h._`${u.default.valCxt}.${u.default.rootData}`),e.dynamicRef&&t.var(u.default.dynamicAnchors,h._`${u.default.valCxt}.${u.default.dynamicAnchors}`)}),(()=>{t.var(u.default.instancePath,h._`""`),t.var(u.default.parentData,h._`undefined`),t.var(u.default.parentDataProperty,h._`undefined`),t.var(u.default.rootData,u.default.data),e.dynamicRef&&t.var(u.default.dynamicAnchors,h._`{}`)}))}(t,r),t.code(o)})):t.func(e,h._`${u.default.data}, ${function(t){return h._`{${u.default.instancePath}="", ${u.default.parentData}, ${u.default.parentDataProperty}, ${u.default.rootData}=${u.default.data}${t.dynamicRef?h._`, ${u.default.dynamicAnchors}={}`:h.nil}}={}`}(r)}`,i.$async,(()=>t.code(g(n,r)).code(o)))}function g(t,e){const n="object"==typeof t&&t[e.schemaId];return n&&(e.code.source||e.code.process)?h._`/*# sourceURL=${n} */`:h.nil}function y({schema:t,self:e}){if("boolean"==typeof t)return!t;for(const n in t)if(e.RULES.all[n])return!0;return!1}function b(t){return"boolean"!=typeof t.schema}function v(t){(0,p.checkUnknownRules)(t),function(t){const{schema:e,errSchemaPath:n,opts:i,self:r}=t;e.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(e,r.RULES)&&r.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(t)}function w(t,e){if(t.opts.jtd)return A(t,[],!1,e);const n=(0,r.getSchemaTypes)(t.schema);A(t,n,!(0,r.coerceAndCheckDataType)(t,n),e)}function C({gen:t,schemaEnv:e,schema:n,errSchemaPath:i,opts:r}){const o=n.$comment;if(!0===r.$comment)t.code(h._`${u.default.self}.logger.log(${o})`);else if("function"==typeof r.$comment){const n=h.str`${i}/$comment`,r=t.scopeValue("root",{ref:e.root});t.code(h._`${u.default.self}.opts.$comment(${o}, ${n}, ${r}.schema)`)}}function A(t,e,n,i){const{gen:r,schema:a,data:l,allErrors:c,opts:d,self:m}=t,{RULES:f}=m;function g(p){(0,o.shouldUseGroup)(a,p)&&(p.type?(r.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),S(t,p),1===e.length&&e[0]===p.type&&n&&(r.else(),(0,s.reportTypeError)(t)),r.endIf()):S(t,p),c||r.if(h._`${u.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(d.jtd||function(t,e){!t.schemaEnv.meta&&t.opts.strictTypes&&(function(t,e){e.length&&(t.dataTypes.length?(e.forEach((e=>{x(t.dataTypes,e)||E(t,`type "${e}" not allowed by context "${t.dataTypes.join(",")}"`)})),function(t,e){const n=[];for(const i of t.dataTypes)x(e,i)?n.push(i):e.includes("integer")&&"number"===i&&n.push("integer");t.dataTypes=n}(t,e)):t.dataTypes=e)}(t,e),t.opts.allowUnionTypes||function(t,e){e.length>1&&(2!==e.length||!e.includes("null"))&&E(t,"use allowUnionTypes to allow union type keyword")}(t,e),function(t,e){const n=t.self.RULES.all;for(const i in n){const r=n[i];if("object"==typeof r&&(0,o.shouldUseRule)(t.schema,r)){const{type:n}=r.definition;n.length&&!n.some((t=>{return i=t,(n=e).includes(i)||"number"===i&&n.includes("integer");var n,i}))&&E(t,`missing type "${n.join(",")}" for keyword "${i}"`)}}}(t,t.dataTypes))}(t,e),r.block((()=>{for(const t of f.rules)g(t);g(f.post)}))):r.block((()=>_(t,"$ref",f.all.$ref.definition)))}function S(t,e){const{gen:n,schema:i,opts:{useDefaults:r}}=t;r&&(0,a.assignDefaults)(t,e.type),n.block((()=>{for(const n of e.rules)(0,o.shouldUseRule)(i,n)&&_(t,n.keyword,n.definition,e.type)}))}function x(t,e){return t.includes(e)||"integer"===e&&t.includes("number")}function E(t,e){e+=` at "${t.schemaEnv.baseId+t.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(t,e,t.opts.strictTypes)}e.validateFunctionCode=function(t){b(t)&&(v(t),y(t))?function(t){const{schema:e,opts:n,gen:i}=t;f(t,(()=>{n.$comment&&e.$comment&&C(t),function(t){const{schema:e,opts:n}=t;void 0!==e.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(t,"default is ignored in the schema root")}(t),i.let(u.default.vErrors,null),i.let(u.default.errors,0),n.unevaluated&&function(t){const{gen:e,validateName:n}=t;t.evaluated=e.const("evaluated",h._`${n}.evaluated`),e.if(h._`${t.evaluated}.dynamicProps`,(()=>e.assign(h._`${t.evaluated}.props`,h._`undefined`))),e.if(h._`${t.evaluated}.dynamicItems`,(()=>e.assign(h._`${t.evaluated}.items`,h._`undefined`)))}(t),w(t),function(t){const{gen:e,schemaEnv:n,validateName:i,ValidationError:r,opts:o}=t;n.$async?e.if(h._`${u.default.errors} === 0`,(()=>e.return(u.default.data)),(()=>e.throw(h._`new ${r}(${u.default.vErrors})`))):(e.assign(h._`${i}.errors`,u.default.vErrors),o.unevaluated&&function({gen:t,evaluated:e,props:n,items:i}){n instanceof h.Name&&t.assign(h._`${e}.props`,n),i instanceof h.Name&&t.assign(h._`${e}.items`,i)}(t),e.return(h._`${u.default.errors} === 0`))}(t)}))}(t):f(t,(()=>(0,i.topBoolOrEmptySchema)(t)))};class M{constructor(t,e,n){if((0,l.validateKeywordUsage)(t,e,n),this.gen=t.gen,this.allErrors=t.allErrors,this.keyword=n,this.data=t.data,this.schema=t.schema[n],this.$data=e.$data&&t.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(t,this.schema,n,this.$data),this.schemaType=e.schemaType,this.parentSchema=t.schema,this.params={},this.it=t,this.def=e,this.$data)this.schemaCode=t.gen.const("vSchema",L(this.$data,t));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,e.schemaType,e.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(e.schemaType)}`);("code"in e?e.trackErrors:!1!==e.errors)&&(this.errsCount=t.gen.const("_errs",u.default.errors))}result(t,e,n){this.failResult((0,h.not)(t),e,n)}failResult(t,e,n){this.gen.if(t),n?n():this.error(),e?(this.gen.else(),e(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(t,e){this.failResult((0,h.not)(t),void 0,e)}fail(t){if(void 0===t)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(t),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(t){if(!this.$data)return this.fail(t);const{schemaCode:e}=this;this.fail(h._`${e} !== undefined && (${(0,h.or)(this.invalid$data(),t)})`)}error(t,e,n){if(e)return this.setParams(e),this._error(t,n),void this.setParams({});this._error(t,n)}_error(t,e){(t?m.reportExtraError:m.reportError)(this,this.def.error,e)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(t){this.allErrors||this.gen.if(t)}setParams(t,e){e?Object.assign(this.params,t):this.params=t}block$data(t,e,n=h.nil){this.gen.block((()=>{this.check$data(t,n),e()}))}check$data(t=h.nil,e=h.nil){if(!this.$data)return;const{gen:n,schemaCode:i,schemaType:r,def:o}=this;n.if((0,h.or)(h._`${i} === undefined`,e)),t!==h.nil&&n.assign(t,!0),(r.length||o.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),t!==h.nil&&n.assign(t,!1)),n.else()}invalid$data(){const{gen:t,schemaCode:e,schemaType:n,def:i,it:r}=this;return(0,h.or)(function(){if(n.length){if(!(e instanceof h.Name))throw new Error("ajv implementation error");const t=Array.isArray(n)?n:[n];return h._`${(0,s.checkDataTypes)(t,e,r.opts.strictNumbers,s.DataType.Wrong)}`}return h.nil}(),function(){if(i.validateSchema){const n=t.scopeValue("validate$data",{ref:i.validateSchema});return h._`!${n}(${e})`}return h.nil}())}subschema(t,e){const n=(0,c.getSubschema)(this.it,t);(0,c.extendSubschemaData)(n,this.it,t),(0,c.extendSubschemaMode)(n,t);const r={...this.it,...n,items:void 0,props:void 0};return function(t,e){b(t)&&(v(t),y(t))?function(t,e){const{schema:n,gen:i,opts:r}=t;r.$comment&&n.$comment&&C(t),function(t){const e=t.schema[t.opts.schemaId];e&&(t.baseId=(0,d.resolveUrl)(t.opts.uriResolver,t.baseId,e))}(t),function(t){if(t.schema.$async&&!t.schemaEnv.$async)throw new Error("async schema in sync schema")}(t);const o=i.const("_errs",u.default.errors);w(t,o),i.var(e,h._`${o} === ${u.default.errors}`)}(t,e):(0,i.boolOrEmptySchema)(t,e)}(r,e),r}mergeEvaluated(t,e){const{it:n,gen:i}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==t.props&&(n.props=p.mergeEvaluated.props(i,t.props,n.props,e)),!0!==n.items&&void 0!==t.items&&(n.items=p.mergeEvaluated.items(i,t.items,n.items,e)))}mergeValidEvaluated(t,e){const{it:n,gen:i}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return i.if(e,(()=>this.mergeEvaluated(t,h.Name))),!0}}function _(t,e,n,i){const r=new M(t,n,e);"code"in n?n.code(r,i):r.$data&&n.validate?(0,l.funcKeywordCode)(r,n):"macro"in n?(0,l.macroKeywordCode)(r,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(r,n)}e.KeywordCxt=M;const I=/^\/(?:[^~]|~0|~1)*$/,T=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function L(t,{dataLevel:e,dataNames:n,dataPathArr:i}){let r,o;if(""===t)return u.default.rootData;if("/"===t[0]){if(!I.test(t))throw new Error(`Invalid JSON-pointer: ${t}`);r=t,o=u.default.rootData}else{const s=T.exec(t);if(!s)throw new Error(`Invalid JSON-pointer: ${t}`);const a=+s[1];if(r=s[2],"#"===r){if(a>=e)throw new Error(l("property/index",a));return i[e-a]}if(a>e)throw new Error(l("data",a));if(o=n[e-a],!r)return o}let s=o;const a=r.split("/");for(const t of a)t&&(o=h._`${o}${(0,h.getProperty)((0,p.unescapeJsonPointer)(t))}`,s=h._`${s} && ${o}`);return s;function l(t,n){return`Cannot access ${t} ${n} levels up, current level is ${e}`}}e.getData=L},3673:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateKeywordUsage=e.validSchemaType=e.funcKeywordCode=e.macroKeywordCode=void 0;const i=n(9029),r=n(2023),o=n(5765),s=n(8708);function a(t){const{gen:e,data:n,it:r}=t;e.if(r.parentData,(()=>e.assign(n,i._`${r.parentData}[${r.parentDataProperty}]`)))}function l(t,e,n){if(void 0===n)throw new Error(`keyword "${e}" failed to compile`);return t.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,i.stringify)(n)})}e.macroKeywordCode=function(t,e){const{gen:n,keyword:r,schema:o,parentSchema:s,it:a}=t,c=e.macro.call(a.self,o,s,a),h=l(n,r,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const u=n.name("valid");t.subschema({schema:c,schemaPath:i.nil,errSchemaPath:`${a.errSchemaPath}/${r}`,topSchemaRef:h,compositeRule:!0},u),t.pass(u,(()=>t.error(!0)))},e.funcKeywordCode=function(t,e){var n;const{gen:c,keyword:h,schema:u,parentSchema:d,$data:p,it:m}=t;!function({schemaEnv:t},e){if(e.async&&!t.$async)throw new Error("async keyword in sync schema")}(m,e);const f=!p&&e.compile?e.compile.call(m.self,u,d,m):e.validate,g=l(c,h,f),y=c.let("valid");function b(n=(e.async?i._`await `:i.nil)){const s=m.opts.passContext?r.default.this:r.default.self,a=!("compile"in e&&!p||!1===e.schema);c.assign(y,i._`${n}${(0,o.callValidateCode)(t,g,s,a)}`,e.modifying)}function v(t){var n;c.if((0,i.not)(null!==(n=e.valid)&&void 0!==n?n:y),t)}t.block$data(y,(function(){if(!1===e.errors)b(),e.modifying&&a(t),v((()=>t.error()));else{const n=e.async?function(){const t=c.let("ruleErrs",null);return c.try((()=>b(i._`await `)),(e=>c.assign(y,!1).if(i._`${e} instanceof ${m.ValidationError}`,(()=>c.assign(t,i._`${e}.errors`)),(()=>c.throw(e))))),t}():function(){const t=i._`${g}.errors`;return c.assign(t,null),b(i.nil),t}();e.modifying&&a(t),v((()=>function(t,e){const{gen:n}=t;n.if(i._`Array.isArray(${e})`,(()=>{n.assign(r.default.vErrors,i._`${r.default.vErrors} === null ? ${e} : ${r.default.vErrors}.concat(${e})`).assign(r.default.errors,i._`${r.default.vErrors}.length`),(0,s.extendErrors)(t)}),(()=>t.error()))}(t,n)))}})),t.ok(null!==(n=e.valid)&&void 0!==n?n:y)},e.validSchemaType=function(t,e,n=!1){return!e.length||e.some((e=>"array"===e?Array.isArray(t):"object"===e?t&&"object"==typeof t&&!Array.isArray(t):typeof t==e||n&&void 0===t))},e.validateKeywordUsage=function({schema:t,opts:e,self:n,errSchemaPath:i},r,o){if(Array.isArray(r.keyword)?!r.keyword.includes(o):r.keyword!==o)throw new Error("ajv implementation error");const s=r.dependencies;if(null==s?void 0:s.some((e=>!Object.prototype.hasOwnProperty.call(t,e))))throw new Error(`parent schema must have dependencies of ${o}: ${s.join(",")}`);if(r.validateSchema&&!r.validateSchema(t[o])){const t=`keyword "${o}" value is invalid at path "${i}": `+n.errorsText(r.validateSchema.errors);if("log"!==e.validateSchema)throw new Error(t);n.logger.error(t)}}},4495:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.extendSubschemaMode=e.extendSubschemaData=e.getSubschema=void 0;const i=n(9029),r=n(4227);e.getSubschema=function(t,{keyword:e,schemaProp:n,schema:o,schemaPath:s,errSchemaPath:a,topSchemaRef:l}){if(void 0!==e&&void 0!==o)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==e){const o=t.schema[e];return void 0===n?{schema:o,schemaPath:i._`${t.schemaPath}${(0,i.getProperty)(e)}`,errSchemaPath:`${t.errSchemaPath}/${e}`}:{schema:o[n],schemaPath:i._`${t.schemaPath}${(0,i.getProperty)(e)}${(0,i.getProperty)(n)}`,errSchemaPath:`${t.errSchemaPath}/${e}/${(0,r.escapeFragment)(n)}`}}if(void 0!==o){if(void 0===s||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:o,schemaPath:s,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},e.extendSubschemaData=function(t,e,{dataProp:n,dataPropType:o,data:s,dataTypes:a,propertyName:l}){if(void 0!==s&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=e;if(void 0!==n){const{errorPath:s,dataPathArr:a,opts:l}=e;h(c.let("data",i._`${e.data}${(0,i.getProperty)(n)}`,!0)),t.errorPath=i.str`${s}${(0,r.getErrorPath)(n,o,l.jsPropertySyntax)}`,t.parentDataProperty=i._`${n}`,t.dataPathArr=[...a,t.parentDataProperty]}function h(n){t.data=n,t.dataLevel=e.dataLevel+1,t.dataTypes=[],e.definedProperties=new Set,t.parentData=e.data,t.dataNames=[...e.dataNames,n]}void 0!==s&&(h(s instanceof i.Name?s:c.let("data",s,!0)),void 0!==l&&(t.propertyName=l)),a&&(t.dataTypes=a)},e.extendSubschemaMode=function(t,{jtdDiscriminator:e,jtdMetadata:n,compositeRule:i,createErrors:r,allErrors:o}){void 0!==i&&(t.compositeRule=i),void 0!==r&&(t.createErrors=r),void 0!==o&&(t.allErrors=o),t.jtdDiscriminator=e,t.jtdMetadata=n}},4042:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.CodeGen=e.Name=e.nil=e.stringify=e.str=e._=e.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(e,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var r=n(9029);Object.defineProperty(e,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(e,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(e,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(e,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(e,"Name",{enumerable:!0,get:function(){return r.Name}}),Object.defineProperty(e,"CodeGen",{enumerable:!0,get:function(){return r.CodeGen}});const o=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),h=n(6939),u=n(208),d=n(4227),p=n(3837),m=n(5944),f=(t,e)=>new RegExp(t,e);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function w(t){var e,n,i,r,o,s,a,l,c,h,u,d,p,g,y,b,v,w,C,A,S,x,E,M,_;const I=t.strict,T=null===(e=t.code)||void 0===e?void 0:e.optimize,L=!0===T||void 0===T?1:T||0,N=null!==(i=null===(n=t.code)||void 0===n?void 0:n.regExp)&&void 0!==i?i:f,P=null!==(r=t.uriResolver)&&void 0!==r?r:m.default;return{strictSchema:null===(s=null!==(o=t.strictSchema)&&void 0!==o?o:I)||void 0===s||s,strictNumbers:null===(l=null!==(a=t.strictNumbers)&&void 0!==a?a:I)||void 0===l||l,strictTypes:null!==(h=null!==(c=t.strictTypes)&&void 0!==c?c:I)&&void 0!==h?h:"log",strictTuples:null!==(d=null!==(u=t.strictTuples)&&void 0!==u?u:I)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(p=t.strictRequired)&&void 0!==p?p:I)&&void 0!==g&&g,code:t.code?{...t.code,optimize:L,regExp:N}:{optimize:L,regExp:N},loopRequired:null!==(y=t.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(b=t.loopEnum)&&void 0!==b?b:200,meta:null===(v=t.meta)||void 0===v||v,messages:null===(w=t.messages)||void 0===w||w,inlineRefs:null===(C=t.inlineRefs)||void 0===C||C,schemaId:null!==(A=t.schemaId)&&void 0!==A?A:"$id",addUsedSchema:null===(S=t.addUsedSchema)||void 0===S||S,validateSchema:null===(x=t.validateSchema)||void 0===x||x,validateFormats:null===(E=t.validateFormats)||void 0===E||E,unicodeRegExp:null===(M=t.unicodeRegExp)||void 0===M||M,int32range:null===(_=t.int32range)||void 0===_||_,uriResolver:P}}class C{constructor(t={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,t=this.opts={...t,...w(t)};const{es5:e,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:e,lines:n}),this.logger=function(t){if(!1===t)return I;if(void 0===t)return console;if(t.log&&t.warn&&t.error)return t;throw new Error("logger must implement log, warn and error methods")}(t.logger);const i=t.validateFormats;t.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,t,"NOT SUPPORTED"),A.call(this,v,t,"DEPRECATED","warn"),this._metaOpts=_.call(this),t.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),t.keywords&&M.call(this,t.keywords),"object"==typeof t.meta&&this.addMetaSchema(t.meta),x.call(this),t.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:t,meta:e,schemaId:n}=this.opts;let i=p;"id"===n&&(i={...p},i.id=i.$id,delete i.$id),e&&t&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:t,schemaId:e}=this.opts;return this.opts.defaultMeta="object"==typeof t?t[e]||t:void 0}validate(t,e){let n;if("string"==typeof t){if(n=this.getSchema(t),!n)throw new Error(`no schema with key or ref "${t}"`)}else n=this.compile(t);const i=n(e);return"$async"in n||(this.errors=n.errors),i}compile(t,e){const n=this._addSchema(t,e);return n.validate||this._compileSchemaEnv(n)}compileAsync(t,e){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return i.call(this,t,e);async function i(t,e){await r.call(this,t.$schema);const n=this._addSchema(t,e);return n.validate||o.call(this,n)}async function r(t){t&&!this.getSchema(t)&&await i.call(this,{$ref:t},!0)}async function o(t){try{return this._compileSchemaEnv(t)}catch(e){if(!(e instanceof s.default))throw e;return a.call(this,e),await l.call(this,e.missingSchema),o.call(this,t)}}function a({missingSchema:t,missingRef:e}){if(this.refs[t])throw new Error(`AnySchema ${t} is loaded but ${e} cannot be resolved`)}async function l(t){const n=await c.call(this,t);this.refs[t]||await r.call(this,n.$schema),this.refs[t]||this.addSchema(n,t,e)}async function c(t){const e=this._loading[t];if(e)return e;try{return await(this._loading[t]=n(t))}finally{delete this._loading[t]}}}addSchema(t,e,n,i=this.opts.validateSchema){if(Array.isArray(t)){for(const e of t)this.addSchema(e,void 0,n,i);return this}let r;if("object"==typeof t){const{schemaId:e}=this.opts;if(r=t[e],void 0!==r&&"string"!=typeof r)throw new Error(`schema ${e} must be string`)}return e=(0,h.normalizeId)(e||r),this._checkUnique(e),this.schemas[e]=this._addSchema(t,n,e,i,!0),this}addMetaSchema(t,e,n=this.opts.validateSchema){return this.addSchema(t,e,!0,n),this}validateSchema(t,e){if("boolean"==typeof t)return!0;let n;if(n=t.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const i=this.validate(n,t);if(!i&&e){const t="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(t);this.logger.error(t)}return i}getSchema(t){let e;for(;"string"==typeof(e=S.call(this,t));)t=e;if(void 0===e){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(e=l.resolveSchema.call(this,i,t),!e)return;this.refs[t]=e}return e.validate||this._compileSchemaEnv(e)}removeSchema(t){if(t instanceof RegExp)return this._removeAllSchemas(this.schemas,t),this._removeAllSchemas(this.refs,t),this;switch(typeof t){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const e=S.call(this,t);return"object"==typeof e&&this._cache.delete(e.schema),delete this.schemas[t],delete this.refs[t],this}case"object":{const e=t;this._cache.delete(e);let n=t[this.opts.schemaId];return n&&(n=(0,h.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(t){for(const e of t)this.addKeyword(e);return this}addKeyword(t,e){let n;if("string"==typeof t)n=t,"object"==typeof e&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),e.keyword=n);else{if("object"!=typeof t||void 0!==e)throw new Error("invalid addKeywords parameters");if(n=(e=t).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(L.call(this,n,e),!e)return(0,d.eachItem)(n,(t=>N.call(this,t))),this;$.call(this,e);const i={...e,type:(0,u.getJSONTypes)(e.type),schemaType:(0,u.getJSONTypes)(e.schemaType)};return(0,d.eachItem)(n,0===i.type.length?t=>N.call(this,t,i):t=>i.type.forEach((e=>N.call(this,t,i,e)))),this}getKeyword(t){const e=this.RULES.all[t];return"object"==typeof e?e.definition:!!e}removeKeyword(t){const{RULES:e}=this;delete e.keywords[t],delete e.all[t];for(const n of e.rules){const e=n.rules.findIndex((e=>e.keyword===t));e>=0&&n.rules.splice(e,1)}return this}addFormat(t,e){return"string"==typeof e&&(e=new RegExp(e)),this.formats[t]=e,this}errorsText(t=this.errors,{separator:e=", ",dataVar:n="data"}={}){return t&&0!==t.length?t.map((t=>`${n}${t.instancePath} ${t.message}`)).reduce(((t,n)=>t+e+n)):"No errors"}$dataMetaSchema(t,e){const n=this.RULES.all;t=JSON.parse(JSON.stringify(t));for(const i of e){const e=i.split("/").slice(1);let r=t;for(const t of e)r=r[t];for(const t in n){const e=n[t];if("object"!=typeof e)continue;const{$data:i}=e.definition,o=r[t];i&&o&&(r[t]=O(o))}}return t}_removeAllSchemas(t,e){for(const n in t){const i=t[n];e&&!e.test(n)||("string"==typeof i?delete t[n]:i&&!i.meta&&(this._cache.delete(i.schema),delete t[n]))}}_addSchema(t,e,n,i=this.opts.validateSchema,r=this.opts.addUsedSchema){let o;const{schemaId:s}=this.opts;if("object"==typeof t)o=t[s];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof t)throw new Error("schema must be object or boolean")}let a=this._cache.get(t);if(void 0!==a)return a;n=(0,h.normalizeId)(o||n);const c=h.getSchemaRefs.call(this,t,n);return a=new l.SchemaEnv({schema:t,schemaId:s,meta:e,baseId:n,localRefs:c}),this._cache.set(a.schema,a),r&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),i&&this.validateSchema(t,!0),a}_checkUnique(t){if(this.schemas[t]||this.refs[t])throw new Error(`schema with key or id "${t}" already exists`)}_compileSchemaEnv(t){if(t.meta?this._compileMetaSchema(t):l.compileSchema.call(this,t),!t.validate)throw new Error("ajv implementation error");return t.validate}_compileMetaSchema(t){const e=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,t)}finally{this.opts=e}}}function A(t,e,n,i="error"){for(const r in t){const o=r;o in e&&this.logger[i](`${n}: option ${r}. ${t[o]}`)}}function S(t){return t=(0,h.normalizeId)(t),this.schemas[t]||this.refs[t]}function x(){const t=this.opts.schemas;if(t)if(Array.isArray(t))this.addSchema(t);else for(const e in t)this.addSchema(t[e],e)}function E(){for(const t in this.opts.formats){const e=this.opts.formats[t];e&&this.addFormat(t,e)}}function M(t){if(Array.isArray(t))this.addVocabulary(t);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const e in t){const n=t[e];n.keyword||(n.keyword=e),this.addKeyword(n)}}}function _(){const t={...this.opts};for(const e of g)delete t[e];return t}C.ValidationError=o.default,C.MissingRefError=s.default,e.default=C;const I={log(){},warn(){},error(){}},T=/^[a-z_$][a-z0-9_$:-]*$/i;function L(t,e){const{RULES:n}=this;if((0,d.eachItem)(t,(t=>{if(n.keywords[t])throw new Error(`Keyword ${t} is already defined`);if(!T.test(t))throw new Error(`Keyword ${t} has invalid name`)})),e&&e.$data&&!("code"in e)&&!("validate"in e))throw new Error('$data keyword must have "code" or "validate" function')}function N(t,e,n){var i;const r=null==e?void 0:e.post;if(n&&r)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:o}=this;let s=r?o.post:o.rules.find((({type:t})=>t===n));if(s||(s={type:n,rules:[]},o.rules.push(s)),o.keywords[t]=!0,!e)return;const a={keyword:t,definition:{...e,type:(0,u.getJSONTypes)(e.type),schemaType:(0,u.getJSONTypes)(e.schemaType)}};e.before?P.call(this,s,a,e.before):s.rules.push(a),o.all[t]=a,null===(i=e.implements)||void 0===i||i.forEach((t=>this.addKeyword(t)))}function P(t,e,n){const i=t.rules.findIndex((t=>t.keyword===n));i>=0?t.rules.splice(i,0,e):(t.rules.push(e),this.logger.warn(`rule ${n} is not defined`))}function $(t){let{metaSchema:e}=t;void 0!==e&&(t.$data&&this.opts.$data&&(e=O(e)),t.validateSchema=this.compile(e,!0))}const R={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(t){return{anyOf:[t,R]}}},9572:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(1678),r=n(7216),o=n(9547),s=n(8226),a=n(518),l=n(4588),c=n(5707),h=n(7082),u=["/properties"];e.default=function(t){return[i,r,o,s,a,e(this,l),c,e(this,h)].forEach((t=>this.addMetaSchema(t,void 0,!1))),this;function e(e,n){return t?e.$dataMetaSchema(n,u):n}}},6250:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2017);i.code='require("ajv/dist/runtime/equal").default',e.default=i},3853:(t,e)=>{"use strict";function n(t){const e=t.length;let n,i=0,r=0;for(;r<e;)i++,n=t.charCodeAt(r++),n>=55296&&n<=56319&&r<e&&(n=t.charCodeAt(r),56320==(64512&n)&&r++);return i}Object.defineProperty(e,"__esModule",{value:!0}),e.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(8343);i.code='require("ajv/dist/runtime/uri").default',e.default=i},3558:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});class n extends Error{constructor(t){super("validation failed"),this.errors=t,this.ajv=this.validation=!0}}e.default=n},5457:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateAdditionalItems=void 0;const i=n(9029),r=n(4227),o={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{parentSchema:e,it:n}=t,{items:i}=e;Array.isArray(i)?s(t,i):(0,r.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function s(t,e){const{gen:n,schema:o,data:s,keyword:a,it:l}=t;l.items=!0;const c=n.const("len",i._`${s}.length`);if(!1===o)t.setParams({len:e.length}),t.pass(i._`${c} <= ${e.length}`);else if("object"==typeof o&&!(0,r.alwaysValidSchema)(l,o)){const o=n.var("valid",i._`${c} <= ${e.length}`);n.if((0,i.not)(o),(()=>function(o){n.forRange("i",e.length,c,(e=>{t.subschema({keyword:a,dataProp:e,dataPropType:r.Type.Num},o),l.allErrors||n.if((0,i.not)(o),(()=>n.break()))}))}(o))),t.ok(o)}}e.validateAdditionalItems=s,e.default=o},8660:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(2023),s=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:t})=>r._`{additionalProperty: ${t.additionalProperty}}`},code(t){const{gen:e,schema:n,parentSchema:a,data:l,errsCount:c,it:h}=t;if(!c)throw new Error("ajv implementation error");const{allErrors:u,opts:d}=h;if(h.props=!0,"all"!==d.removeAdditional&&(0,s.alwaysValidSchema)(h,n))return;const p=(0,i.allSchemaProperties)(a.properties),m=(0,i.allSchemaProperties)(a.patternProperties);function f(t){e.code(r._`delete ${l}[${t}]`)}function g(i){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)f(i);else{if(!1===n)return t.setParams({additionalProperty:i}),t.error(),void(u||e.break());if("object"==typeof n&&!(0,s.alwaysValidSchema)(h,n)){const n=e.name("valid");"failing"===d.removeAdditional?(y(i,n,!1),e.if((0,r.not)(n),(()=>{t.reset(),f(i)}))):(y(i,n),u||e.if((0,r.not)(n),(()=>e.break())))}}}function y(e,n,i){const r={keyword:"additionalProperties",dataProp:e,dataPropType:s.Type.Str};!1===i&&Object.assign(r,{compositeRule:!0,createErrors:!1,allErrors:!1}),t.subschema(r,n)}e.forIn("key",l,(n=>{p.length||m.length?e.if(function(n){let o;if(p.length>8){const t=(0,s.schemaRefOrVal)(h,a.properties,"properties");o=(0,i.isOwnProperty)(e,t,n)}else o=p.length?(0,r.or)(...p.map((t=>r._`${n} === ${t}`))):r.nil;return m.length&&(o=(0,r.or)(o,...m.map((e=>r._`${(0,i.usePattern)(t,e)}.test(${n})`)))),(0,r.not)(o)}(n),(()=>g(n))):g(n)})),t.ok(r._`${c} === ${o.default.errors}`)}};e.default=a},5844:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:"allOf",schemaType:"array",code(t){const{gen:e,schema:n,it:r}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");const o=e.name("valid");n.forEach(((e,n)=>{if((0,i.alwaysValidSchema)(r,e))return;const s=t.subschema({keyword:"allOf",schemaProp:n},o);t.ok(o),t.mergeEvaluated(s)}))}};e.default=r},6505:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};e.default=i},2661:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:t,max:e}})=>void 0===e?i.str`must contain at least ${t} valid item(s)`:i.str`must contain at least ${t} and no more than ${e} valid item(s)`,params:({params:{min:t,max:e}})=>void 0===e?i._`{minContains: ${t}}`:i._`{minContains: ${t}, maxContains: ${e}}`},code(t){const{gen:e,schema:n,parentSchema:o,data:s,it:a}=t;let l,c;const{minContains:h,maxContains:u}=o;a.opts.next?(l=void 0===h?1:h,c=u):l=1;const d=e.const("len",i._`${s}.length`);if(t.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,r.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,r.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void t.fail();if((0,r.alwaysValidSchema)(a,n)){let e=i._`${d} >= ${l}`;return void 0!==c&&(e=i._`${e} && ${d} <= ${c}`),void t.pass(e)}a.items=!0;const p=e.name("valid");function m(){const t=e.name("_valid"),n=e.let("count",0);f(t,(()=>e.if(t,(()=>function(t){e.code(i._`${t}++`),void 0===c?e.if(i._`${t} >= ${l}`,(()=>e.assign(p,!0).break())):(e.if(i._`${t} > ${c}`,(()=>e.assign(p,!1).break())),1===l?e.assign(p,!0):e.if(i._`${t} >= ${l}`,(()=>e.assign(p,!0))))}(n)))))}function f(n,i){e.forRange("i",0,d,(e=>{t.subschema({keyword:"contains",dataProp:e,dataPropType:r.Type.Num,compositeRule:!0},n),i()}))}void 0===c&&1===l?f(p,(()=>e.if(p,(()=>e.break())))):0===l?(e.let(p,!0),void 0!==c&&e.if(i._`${s}.length > 0`,m)):(e.let(p,!1),m()),t.result(p,(()=>t.reset()))}};e.default=o},3025:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateSchemaDeps=e.validatePropertyDeps=e.error=void 0;const i=n(9029),r=n(4227),o=n(5765);e.error={message:({params:{property:t,depsCount:e,deps:n}})=>{const r=1===e?"property":"properties";return i.str`must have ${r} ${n} when property ${t} is present`},params:({params:{property:t,depsCount:e,deps:n,missingProperty:r}})=>i._`{property: ${t},
     missingProperty: ${r},
     depsCount: ${e},
-    deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:e.error,code(t){const[e,n]=function({schema:t}){const e={},n={};for(const i in t)"__proto__"!==i&&((Array.isArray(t[i])?e:n)[i]=t[i]);return[e,n]}(t);a(t,e),l(t,n)}};function a(t,e=t.schema){const{gen:n,data:r,it:s}=t;if(0===Object.keys(e).length)return;const a=n.let("missing");for(const l in e){const c=e[l];if(0===c.length)continue;const h=(0,o.propertyInData)(n,r,l,s.opts.ownProperties);t.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(h,(()=>{for(const e of c)(0,o.checkReportMissingProp)(t,e)})):(n.if(i._`${h} && (${(0,o.checkMissingProp)(t,c,a)})`),(0,o.reportMissingProp)(t,a),n.else())}}function l(t,e=t.schema){const{gen:n,data:i,keyword:s,it:a}=t,l=n.name("valid");for(const c in e)(0,r.alwaysValidSchema)(a,e[c])||(n.if((0,o.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const e=t.subschema({keyword:s,schemaProp:c},l);t.mergeValidEvaluated(e,l)}),(()=>n.var(l,!0))),t.ok(l))}e.validatePropertyDeps=a,e.validateSchemaDeps=l,e.default=s},4845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:t=>(0,i.validateSchemaDeps)(t)};e.default=r},1239:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:t})=>i.str`must match "${t.ifClause}" schema`,params:({params:t})=>i._`{failingKeyword: ${t.ifClause}}`},code(t){const{gen:e,parentSchema:n,it:o}=t;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(o,'"if" without "then" and "else" is ignored');const a=s(o,"then"),l=s(o,"else");if(!a&&!l)return;const c=e.let("valid",!0),h=e.name("_valid");if(function(){const e=t.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},h);t.mergeEvaluated(e)}(),t.reset(),a&&l){const n=e.let("ifClause");t.setParams({ifClause:n}),e.if(h,u("then",n),u("else",n))}else a?e.if(h,u("then")):e.if((0,i.not)(h),u("else"));function u(n,r){return()=>{const o=t.subschema({keyword:n},h);e.assign(c,h),t.mergeValidEvaluated(o,c),r?e.assign(r,i._`${n}`):t.setParams({ifClause:n})}}t.pass(c,(()=>t.error(!0)))}};function s(t,e){const n=t.schema[e];return void 0!==n&&!(0,r.alwaysValidSchema)(t,n)}e.default=o},6378:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5457),r=n(5354),o=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),h=n(8660),u=n(117),d=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),b=n(4426);e.default=function(t=!1){const e=[p.default,m.default,f.default,g.default,y.default,b.default,c.default,h.default,l.default,u.default,d.default];return t?e.push(r.default,s.default):e.push(i.default,o.default),e.push(a.default),e}},494:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateTuple=void 0;const i=n(9029),r=n(4227),o=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(t){const{schema:e,it:n}=t;if(Array.isArray(e))return a(t,"additionalItems",e);n.items=!0,(0,r.alwaysValidSchema)(n,e)||t.ok((0,o.validateArray)(t))}};function a(t,e,n=t.schema){const{gen:o,parentSchema:s,data:a,keyword:l,it:c}=t;!function(t){const{opts:i,errSchemaPath:o}=c,s=n.length,a=s===t.minItems&&(s===t.maxItems||!1===t[e]);if(i.strictTuples&&!a){const t=`"${l}" is ${s}-tuple, but minItems or maxItems/${e} are not specified or different at path "${o}"`;(0,r.checkStrictMode)(c,t,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(o,n.length,c.items));const h=o.name("valid"),u=o.const("len",i._`${a}.length`);n.forEach(((e,n)=>{(0,r.alwaysValidSchema)(c,e)||(o.if(i._`${u} > ${n}`,(()=>t.subschema({keyword:l,schemaProp:n,dataProp:n},h))),t.ok(h))}))}e.validateTuple=a,e.default=s},3966:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{schema:e,parentSchema:n,it:i}=t,{prefixItems:a}=n;i.items=!0,(0,r.alwaysValidSchema)(i,e)||(a?(0,s.validateAdditionalItems)(t,a):t.ok((0,o.validateArray)(t)))}};e.default=a},7923:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(t){const{gen:e,schema:n,it:r}=t;if((0,i.alwaysValidSchema)(r,n))return void t.fail();const o=e.name("valid");t.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},o),t.failResult(o,(()=>t.reset()),(()=>t.error()))},error:{message:"must NOT be valid"}};e.default=r},6163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:t})=>i._`{passingSchemas: ${t.passing}}`},code(t){const{gen:e,schema:n,parentSchema:o,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&o.discriminator)return;const a=n,l=e.let("valid",!1),c=e.let("passing",null),h=e.name("_valid");t.setParams({passing:c}),e.block((function(){a.forEach(((n,o)=>{let a;(0,r.alwaysValidSchema)(s,n)?e.var(h,!0):a=t.subschema({keyword:"oneOf",schemaProp:o,compositeRule:!0},h),o>0&&e.if(i._`${h} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${o}]`).else(),e.if(h,(()=>{e.assign(l,!0),e.assign(c,o),a&&t.mergeEvaluated(a,i.Name)}))}))})),t.result(l,(()=>t.reset()),(()=>t.error(!0)))}};e.default=o},5333:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,data:a,parentSchema:l,it:c}=t,{opts:h}=c,u=(0,i.allSchemaProperties)(n),d=u.filter((t=>(0,o.alwaysValidSchema)(c,n[t])));if(0===u.length||d.length===u.length&&(!c.opts.unevaluated||!0===c.props))return;const p=h.strictSchema&&!h.allowMatchingProperties&&l.properties,m=e.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,s.evaluatedPropsToName)(e,c.props));const{props:f}=c;function g(t){for(const e in p)new RegExp(t).test(e)&&(0,o.checkStrictMode)(c,`property ${e} matches pattern ${t} (use allowMatchingProperties)`)}function y(n){e.forIn("key",a,(o=>{e.if(r._`${(0,i.usePattern)(t,n)}.test(${o})`,(()=>{const i=d.includes(n);i||t.subschema({keyword:"patternProperties",schemaProp:n,dataProp:o,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==f?e.assign(r._`${f}[${o}]`,!0):i||c.allErrors||e.if((0,r.not)(m),(()=>e.break()))}))}))}!function(){for(const t of u)p&&g(t),c.allErrors?y(t):(e.var(m,!0),y(t),e.if(m))}()}};e.default=a},5354:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(494),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:t=>(0,i.validateTuple)(t,"items")};e.default=r},117:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2586),r=n(5765),o=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,parentSchema:a,data:l,it:c}=t;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const h=(0,r.allSchemaProperties)(n);for(const t of h)c.definedProperties.add(t);c.opts.unevaluated&&h.length&&!0!==c.props&&(c.props=o.mergeEvaluated.props(e,(0,o.toHash)(h),c.props));const u=h.filter((t=>!(0,o.alwaysValidSchema)(c,n[t])));if(0===u.length)return;const d=e.name("valid");for(const n of u)p(n)?m(n):(e.if((0,r.propertyInData)(e,l,n,c.opts.ownProperties)),m(n),c.allErrors||e.else().var(d,!0),e.endIf()),t.it.definedProperties.add(n),t.ok(d);function p(t){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[t].default}function m(e){t.subschema({keyword:"properties",schemaProp:e,dataProp:e},d)}}};e.default=a},2094:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:t})=>i._`{propertyName: ${t.propertyName}}`},code(t){const{gen:e,schema:n,data:o,it:s}=t;if((0,r.alwaysValidSchema)(s,n))return;const a=e.name("valid");e.forIn("key",o,(n=>{t.setParams({propertyName:n}),t.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),e.if((0,i.not)(a),(()=>{t.error(!0),s.allErrors||e.break()}))})),t.ok(a)}};e.default=o},4426:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:t,parentSchema:e,it:n}){void 0===e.if&&(0,i.checkStrictMode)(n,`"${t}" without "if" is ignored`)}};e.default=r},5765:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateUnion=e.validateArray=e.usePattern=e.callValidateCode=e.schemaProperties=e.allSchemaProperties=e.noPropertyInData=e.propertyInData=e.isOwnProperty=e.hasPropFunc=e.reportMissingProp=e.checkMissingProp=e.checkReportMissingProp=void 0;const i=n(9029),r=n(4227),o=n(2023),s=n(4227);function a(t){return t.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(t,e,n){return i._`${a(t)}.call(${e}, ${n})`}function c(t,e,n,r){const o=i._`${e}${(0,i.getProperty)(n)} === undefined`;return r?(0,i.or)(o,(0,i.not)(l(t,e,n))):o}function h(t){return t?Object.keys(t).filter((t=>"__proto__"!==t)):[]}e.checkReportMissingProp=function(t,e){const{gen:n,data:r,it:o}=t;n.if(c(n,r,e,o.opts.ownProperties),(()=>{t.setParams({missingProperty:i._`${e}`},!0),t.error()}))},e.checkMissingProp=function({gen:t,data:e,it:{opts:n}},r,o){return(0,i.or)(...r.map((r=>(0,i.and)(c(t,e,r,n.ownProperties),i._`${o} = ${r}`))))},e.reportMissingProp=function(t,e){t.setParams({missingProperty:e},!0),t.error()},e.hasPropFunc=a,e.isOwnProperty=l,e.propertyInData=function(t,e,n,r){const o=i._`${e}${(0,i.getProperty)(n)} !== undefined`;return r?i._`${o} && ${l(t,e,n)}`:o},e.noPropertyInData=c,e.allSchemaProperties=h,e.schemaProperties=function(t,e){return h(e).filter((n=>!(0,r.alwaysValidSchema)(t,e[n])))},e.callValidateCode=function({schemaCode:t,data:e,it:{gen:n,topSchemaRef:r,schemaPath:s,errorPath:a},it:l},c,h,u){const d=u?i._`${t}, ${e}, ${r}${s}`:e,p=[[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,a)],[o.default.parentData,l.parentData],[o.default.parentDataProperty,l.parentDataProperty],[o.default.rootData,o.default.rootData]];l.opts.dynamicRef&&p.push([o.default.dynamicAnchors,o.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return h!==i.nil?i._`${c}.call(${h}, ${m})`:i._`${c}(${m})`};const u=i._`new RegExp`;e.usePattern=function({gen:t,it:{opts:e}},n){const r=e.unicodeRegExp?"u":"",{regExp:o}=e.code,a=o(n,r);return t.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===o.code?u:(0,s.useFunc)(t,o)}(${n}, ${r})`})},e.validateArray=function(t){const{gen:e,data:n,keyword:o,it:s}=t,a=e.name("valid");if(s.allErrors){const t=e.let("valid",!0);return l((()=>e.assign(t,!1))),t}return e.var(a,!0),l((()=>e.break())),a;function l(s){const l=e.const("len",i._`${n}.length`);e.forRange("i",0,l,(n=>{t.subschema({keyword:o,dataProp:n,dataPropType:r.Type.Num},a),e.if((0,i.not)(a),s)}))}},e.validateUnion=function(t){const{gen:e,schema:n,keyword:o,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((t=>(0,r.alwaysValidSchema)(s,t)))&&!s.opts.unevaluated)return;const a=e.let("valid",!1),l=e.name("_valid");e.block((()=>n.forEach(((n,r)=>{const s=t.subschema({keyword:o,schemaProp:r,compositeRule:!0},l);e.assign(a,i._`${a} || ${l}`),t.mergeValidEvaluated(s,l)||e.if((0,i.not)(a))})))),t.result(a,(()=>t.reset()),(()=>t.error(!0)))}},3463:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};e.default=n},2128:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3463),r=n(3693),o=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,r.default];e.default=o},3693:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.callRef=e.getValidate=void 0;const i=n(4551),r=n(5765),o=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(t){const{gen:e,schema:n,it:r}=t,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=r,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return u(t,c,l,l.$async);const n=e.scopeValue("root",{ref:m});return u(t,o._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,s,n);if(void 0===f)throw new i.default(r.opts.uriResolver,s,n);return f instanceof a.SchemaEnv?function(e){const n=h(t,e);u(t,n,e,e.$async)}(f):function(i){const r=e.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,o.stringify)(i)}:{ref:i}),s=e.name("valid"),a=t.subschema({schema:i,dataTypes:[],schemaPath:o.nil,topSchemaRef:r,errSchemaPath:n},s);t.mergeEvaluated(a),t.ok(s)}(f)}};function h(t,e){const{gen:n}=t;return e.validate?n.scopeValue("validate",{ref:e.validate}):o._`${n.scopeValue("wrapper",{ref:e})}.validate`}function u(t,e,n,i){const{gen:a,it:c}=t,{allErrors:h,schemaEnv:u,opts:d}=c,p=d.passContext?s.default.this:o.nil;function m(t){const e=o._`${t}.errors`;a.assign(s.default.vErrors,o._`${s.default.vErrors} === null ? ${e} : ${s.default.vErrors}.concat(${e})`),a.assign(s.default.errors,o._`${s.default.vErrors}.length`)}function f(t){var e;if(!c.opts.unevaluated)return;const i=null===(e=null==n?void 0:n.validate)||void 0===e?void 0:e.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const e=a.var("props",o._`${t}.evaluated.props`);c.props=l.mergeEvaluated.props(a,e,c.props,o.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const e=a.var("items",o._`${t}.evaluated.items`);c.items=l.mergeEvaluated.items(a,e,c.items,o.Name)}}i?function(){if(!u.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(o._`await ${(0,r.callValidateCode)(t,e,p)}`),f(e),h||a.assign(n,!0)}),(t=>{a.if(o._`!(${t} instanceof ${c.ValidationError})`,(()=>a.throw(t))),m(t),h||a.assign(n,!1)})),t.ok(n)}():t.result((0,r.callValidateCode)(t,e,p),(()=>f(e)),(()=>m(e)))}e.getValidate=h,e.callRef=u,e.default=c},6653:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(7652),o=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:t,tagName:e}})=>t===r.DiscrError.Tag?`tag "${e}" must be string`:`value of tag "${e}" must be in oneOf`,params:({params:{discrError:t,tag:e,tagName:n}})=>i._`{error: ${t}, tag: ${n}, tagValue: ${e}}`},code(t){const{gen:e,data:n,schema:l,parentSchema:c,it:h}=t,{oneOf:u}=c;if(!h.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!u)throw new Error("discriminator: requires oneOf keyword");const p=e.let("valid",!1),m=e.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function f(n){const r=e.name("valid"),o=t.subschema({keyword:"oneOf",schemaProp:n},r);return t.mergeEvaluated(o,i.Name),r}e.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var t;const e={},n=r(c);let i=!0;for(let e=0;e<u.length;e++){let c=u[e];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,h.self.RULES)){const t=c.$ref;if(c=o.resolveRef.call(h.self,h.schemaEnv.root,h.baseId,t),c instanceof o.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(h.opts.uriResolver,h.baseId,t)}const p=null===(t=null==c?void 0:c.properties)||void 0===t?void 0:t[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||r(c)),l(p,e)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return e;function r({required:t}){return Array.isArray(t)&&t.includes(d)}function l(t,e){if(t.const)p(t.const,e);else{if(!t.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of t.enum)p(n,e)}}function p(t,n){if("string"!=typeof t||t in e)throw new Error(`discriminator: "${d}" values must be unique strings`);e[t]=n}}();e.if(!1);for(const t in n)e.elseIf(i._`${m} === ${t}`),e.assign(p,f(n[t]));e.else(),t.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:d}),e.endIf()}()),(()=>t.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:d}))),t.ok(p)}};e.default=l},7652:(t,e)=>{"use strict";var n;Object.defineProperty(e,"__esModule",{value:!0}),e.DiscrError=void 0,function(t){t.Tag="tag",t.Mapping="mapping"}(n||(e.DiscrError=n={}))},6105:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),h=n(9857),u=[s.default,i.default,r.default,(0,o.default)(!0),c.default,h.metadataVocabulary,h.contentVocabulary,a.default,l.default];e.default=u},6144:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(7532),a=n(9857),l=[i.default,r.default,(0,o.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];e.default=l},2476:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicAnchor=void 0;const i=n(9029),r=n(2023),o=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:t=>l(t,t.schema)};function l(t,e){const{gen:n,it:a}=t;a.schemaEnv.root.dynamicAnchors[e]=!0;const l=i._`${r.default.dynamicAnchors}${(0,i.getProperty)(e)}`,c="#"===a.errSchemaPath?a.validateName:function(t){const{schemaEnv:e,schema:n,self:i}=t.it,{root:r,baseId:a,localRefs:l,meta:c}=e.root,{schemaId:h}=i.opts,u=new o.SchemaEnv({schema:n,schemaId:h,root:r,baseId:a,localRefs:l,meta:c});return o.compileSchema.call(i,u),(0,s.getValidate)(t,u)}(t);n.if(i._`!${l}`,(()=>n.assign(l,c)))}e.dynamicAnchor=l,e.default=a},3252:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicRef=void 0;const i=n(9029),r=n(2023),o=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:t=>a(t,t.schema)};function a(t,e){const{gen:n,keyword:s,it:a}=t;if("#"!==e[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=e.slice(1);if(a.allErrors)c();else{const e=n.let("valid",!1);c(e),t.ok(e)}function c(t){if(a.schemaEnv.root.dynamicAnchors[l]){const e=n.let("_v",i._`${r.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(e,h(e,t),h(a.validateName,t))}else h(a.validateName,t)()}function h(e,i){return i?()=>n.block((()=>{(0,o.callRef)(t,e),n.let(i,!0)})):()=>(0,o.callRef)(t,e)}}e.dynamicRef=a,e.default=s},5520:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),r=n(3252),o=n(2721),s=n(3799),a=[i.default,r.default,o.default,s.default];e.default=a},2721:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),r=n(4227),o={keyword:"$recursiveAnchor",schemaType:"boolean",code(t){t.schema?(0,i.dynamicAnchor)(t,""):(0,r.checkStrictMode)(t.it,"$recursiveAnchor: false is ignored")}};e.default=o},3799:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3252),r={keyword:"$recursiveRef",schemaType:"string",code:t=>(0,i.dynamicRef)(t,t.schema)};e.default=r},4737:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>i.str`must match format "${t}"`,params:({schemaCode:t})=>i._`{format: ${t}}`},code(t,e){const{gen:n,data:r,$data:o,schema:s,schemaCode:a,it:l}=t,{opts:c,errSchemaPath:h,schemaEnv:u,self:d}=l;c.validateFormats&&(o?function(){const o=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${o}[${a}]`),l=n.let("fType"),h=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(h,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(h,s))),t.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${h}`,function(){const t=u.$async?i._`(${s}.async ? await ${h}(${r}) : ${h}(${r}))`:i._`${h}(${r})`,n=i._`(typeof ${h} == "function" ? ${t} : ${h}.test(${r}))`;return i._`${h} && ${h} !== true && ${l} === ${e} && !${n}`}()))}():function(){const o=d.formats[s];if(!o)return void function(){if(!1!==c.strictSchema)throw new Error(t());function t(){return`unknown format "${s}" ignored in schema at path "${h}"`}d.logger.warn(t())}();if(!0===o)return;const[a,l,p]=function(t){const e=t instanceof RegExp?(0,i.regexpCode)(t):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,r=n.scopeValue("formats",{key:s,ref:t,code:e});return"object"!=typeof t||t instanceof RegExp?["string",t,r]:[t.type||"string",t.validate,i._`${r}.validate`]}(o);a===e&&t.pass(function(){if("object"==typeof o&&!(o instanceof RegExp)&&o.async){if(!u.$async)throw new Error("async format in sync schema");return i._`await ${p}(${r})`}return"function"==typeof l?i._`${p}(${r})`:i._`${p}.test(${r})`}())}())}};e.default=r},7532:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=[n(4737).default];e.default=i},9857:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.contentVocabulary=e.metadataVocabulary=void 0,e.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],e.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(1846),r=n(4845),o=n(2626),s=[i.default,r.default,o.default];e.default=s},3265:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(392),r=n(3445),o=[i.default,r.default];e.default=o},3445:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{gen:e,schema:n,data:o,it:s}=t,a=s.items||0;if(!0===a)return;const l=e.const("len",i._`${o}.length`);if(!1===n)t.setParams({len:a}),t.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(s,n)){const n=e.var("valid",i._`${l} <= ${a}`);e.if((0,i.not)(n),(()=>function(n,o){e.forRange("i",o,l,(o=>{t.subschema({keyword:"unevaluatedItems",dataProp:o,dataPropType:r.Type.Num},n),s.allErrors||e.if((0,i.not)(n),(()=>e.break()))}))}(n,a))),t.ok(n)}s.items=!0}};e.default=o},392:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:t})=>i._`{unevaluatedProperty: ${t.unevaluatedProperty}}`},code(t){const{gen:e,schema:n,data:s,errsCount:a,it:l}=t;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:h}=l;function u(o){if(!1===n)return t.setParams({unevaluatedProperty:o}),t.error(),void(c||e.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=e.name("valid");t.subschema({keyword:"unevaluatedProperties",dataProp:o,dataPropType:r.Type.Str},n),c||e.if((0,i.not)(n),(()=>e.break()))}}h instanceof i.Name?e.if(i._`${h} !== true`,(()=>e.forIn("key",s,(t=>e.if(function(t,e){return i._`!${t} || !${t}[${e}]`}(h,t),(()=>u(t))))))):!0!==h&&e.forIn("key",s,(t=>void 0===h?u(t):e.if(function(t,e){const n=[];for(const r in t)!0===t[r]&&n.push(i._`${e} !== ${r}`);return(0,i.and)(...n)}(h,t),(()=>u(t))))),l.props=!0,t.ok(i._`${a} === ${o.default.errors}`)}};e.default=s},7935:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:t})=>i._`{allowedValue: ${t}}`},code(t){const{gen:e,data:n,$data:s,schemaCode:a,schema:l}=t;s||l&&"object"==typeof l?t.fail$data(i._`!${(0,r.useFunc)(e,o.default)}(${n}, ${a})`):t.fail(i._`${l} !== ${n}`)}};e.default=s},1846:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:t=>(0,i.validatePropertyDeps)(t)};e.default=r},8643:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:t})=>i._`{allowedValues: ${t}}`},code(t){const{gen:e,data:n,$data:s,schema:a,schemaCode:l,it:c}=t;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const h=a.length>=c.opts.loopEnum;let u;const d=()=>null!=u?u:u=(0,r.useFunc)(e,o.default);let p;if(h||s)p=e.let("valid"),t.block$data(p,(function(){e.assign(p,!1),e.forOf("v",l,(t=>e.if(i._`${d()}(${n}, ${t})`,(()=>e.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const t=e.const("vSchema",l);p=(0,i.or)(...a.map(((e,r)=>function(t,e){const r=a[e];return"object"==typeof r&&null!==r?i._`${d()}(${n}, ${t}[${e}])`:i._`${n} === ${r}`}(t,r))))}t.pass(p)}};e.default=s},7060:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5882),r=n(3439),o=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),h=n(617),u=n(7935),d=n(8643),p=[i.default,r.default,o.default,s.default,a.default,l.default,c.default,h.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},u.default,d.default];e.default=p},2626:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:t,parentSchema:e,it:n}){void 0===e.contains&&(0,i.checkStrictMode)(n,`"${t}" without "contains" is ignored`)}};e.default=r},1163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxItems"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} items`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:r}=t,o="maxItems"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`${n}.length ${o} ${r}`)}};e.default=r},7307:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxLength"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} characters`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:s,it:a}=t,l="maxLength"===e?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,r.useFunc)(t.gen,o.default)}(${n})`;t.fail$data(i._`${c} ${l} ${s}`)}};e.default=s},5882:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=i.operators,o={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},s={message:({keyword:t,schemaCode:e})=>i.str`must be ${o[t].okStr} ${e}`,params:({keyword:t,schemaCode:e})=>i._`{comparison: ${o[t].okStr}, limit: ${e}}`},a={keyword:Object.keys(o),type:"number",schemaType:"number",$data:!0,error:s,code(t){const{keyword:e,data:n,schemaCode:r}=t;t.fail$data(i._`${n} ${o[e].fail} ${r} || isNaN(${n})`)}};e.default=a},4486:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxProperties"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} properties`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:r}=t,o="maxProperties"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`Object.keys(${n}).length ${o} ${r}`)}};e.default=r},3439:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:t})=>i.str`must be multiple of ${t}`,params:({schemaCode:t})=>i._`{multipleOf: ${t}}`},code(t){const{gen:e,data:n,schemaCode:r,it:o}=t,s=o.opts.multipleOfPrecision,a=e.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;t.fail$data(i._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};e.default=r},422:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>r.str`must match pattern "${t}"`,params:({schemaCode:t})=>r._`{pattern: ${t}}`},code(t){const{data:e,$data:n,schema:o,schemaCode:s,it:a}=t,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(t,o);t.fail$data(r._`!${c}.test(${e})`)}};e.default=o},4003:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:t}})=>r.str`must have required property '${t}'`,params:({params:{missingProperty:t}})=>r._`{missingProperty: ${t}}`},code(t){const{gen:e,schema:n,schemaCode:s,data:a,$data:l,it:c}=t,{opts:h}=c;if(!l&&0===n.length)return;const u=n.length>=h.loopRequired;if(c.allErrors?function(){if(u||l)t.block$data(r.nil,d);else for(const e of n)(0,i.checkReportMissingProp)(t,e)}():function(){const o=e.let("missing");if(u||l){const n=e.let("valid",!0);t.block$data(n,(()=>function(n,o){t.setParams({missingProperty:n}),e.forOf(n,s,(()=>{e.assign(o,(0,i.propertyInData)(e,a,n,h.ownProperties)),e.if((0,r.not)(o),(()=>{t.error(),e.break()}))}),r.nil)}(o,n))),t.ok(n)}else e.if((0,i.checkMissingProp)(t,n,o)),(0,i.reportMissingProp)(t,o),e.else()}(),h.strictRequired){const e=t.parentSchema.properties,{definedProperties:i}=t.it;for(const t of n)if(void 0===(null==e?void 0:e[t])&&!i.has(t)){const e=`required property "${t}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,o.checkStrictMode)(c,e,c.opts.strictRequired)}}function d(){e.forOf("prop",s,(n=>{t.setParams({missingProperty:n}),e.if((0,i.noPropertyInData)(e,a,n,h.ownProperties),(()=>t.error()))}))}}};e.default=s},617:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(208),r=n(9029),o=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:t,j:e}})=>r.str`must NOT have duplicate items (items ## ${e} and ${t} are identical)`,params:({params:{i:t,j:e}})=>r._`{i: ${t}, j: ${e}}`},code(t){const{gen:e,data:n,$data:a,schema:l,parentSchema:c,schemaCode:h,it:u}=t;if(!a&&!l)return;const d=e.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(o,s){const a=e.name("item"),l=(0,i.checkDataTypes)(p,a,u.opts.strictNumbers,i.DataType.Wrong),c=e.const("indices",r._`{}`);e.for(r._`;${o}--;`,(()=>{e.let(a,r._`${n}[${o}]`),e.if(l,r._`continue`),p.length>1&&e.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),e.if(r._`typeof ${c}[${a}] == "number"`,(()=>{e.assign(s,r._`${c}[${a}]`),t.error(),e.assign(d,!1).break()})).code(r._`${c}[${a}] = ${o}`)}))}function f(i,a){const l=(0,o.useFunc)(e,s.default),c=e.name("outer");e.label(c).for(r._`;${i}--;`,(()=>e.for(r._`${a} = ${i}; ${a}--;`,(()=>e.if(r._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{t.error(),e.assign(d,!1).break(c)}))))))}t.block$data(d,(function(){const i=e.let("i",r._`${n}.length`),o=e.let("j");t.setParams({i,j:o}),e.assign(d,!0),e.if(r._`${i} > 1`,(()=>(p.length>0&&!p.some((t=>"object"===t||"array"===t))?m:f)(i,o)))}),r._`${h} === false`),t.ok(d)}};e.default=a},5488:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}"],sourceRoot:""}]);const a=s},857:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314:t=>{"use strict";t.exports=function(t){var e=[];return e.toString=function(){return this.map((function(e){var n="",i=void 0!==e[5];return e[4]&&(n+="@supports (".concat(e[4],") {")),e[2]&&(n+="@media ".concat(e[2]," {")),i&&(n+="@layer".concat(e[5].length>0?" ".concat(e[5]):""," {")),n+=t(e),i&&(n+="}"),e[2]&&(n+="}"),e[4]&&(n+="}"),n})).join("")},e.i=function(t,n,i,r,o){"string"==typeof t&&(t=[[null,t,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<t.length;c++){var h=[].concat(t[c]);i&&s[h[0]]||(void 0!==o&&(void 0===h[5]||(h[1]="@layer".concat(h[5].length>0?" ".concat(h[5]):""," {").concat(h[1],"}")),h[5]=o),n&&(h[2]?(h[1]="@media ".concat(h[2]," {").concat(h[1],"}"),h[2]=n):h[2]=n),r&&(h[4]?(h[1]="@supports (".concat(h[4],") {").concat(h[1],"}"),h[4]=r):h[4]="".concat(r)),e.push(h))}},e}},1354:t=>{"use strict";t.exports=function(t){var e=t[1],n=t[3];if(!n)return e;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),o="/*# ".concat(r," */");return[e].concat([o]).join("\n")}return[e].join("\n")}},2017:t=>{"use strict";t.exports=function t(e,n){if(e===n)return!0;if(e&&n&&"object"==typeof e&&"object"==typeof n){if(e.constructor!==n.constructor)return!1;var i,r,o;if(Array.isArray(e)){if((i=e.length)!=n.length)return!1;for(r=i;0!=r--;)if(!t(e[r],n[r]))return!1;return!0}if(e.constructor===RegExp)return e.source===n.source&&e.flags===n.flags;if(e.valueOf!==Object.prototype.valueOf)return e.valueOf()===n.valueOf();if(e.toString!==Object.prototype.toString)return e.toString()===n.toString();if((i=(o=Object.keys(e)).length)!==Object.keys(n).length)return!1;for(r=i;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,o[r]))return!1;for(r=i;0!=r--;){var s=o[r];if(!t(e[s],n[s]))return!1}return!0}return e!=e&&n!=n}},9982:function(t,e,n){var i;!function(){var e={};!function(t){"use strict";t.__esModule=!0,t.digestLength=32,t.blockSize=64;var e=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(t,n,i,r,o){for(var s,a,l,c,h,u,d,p,m,f,g,y,b;o>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],h=n[4],u=n[5],d=n[6],p=n[7],f=0;f<16;f++)g=r+4*f,t[f]=(255&i[g])<<24|(255&i[g+1])<<16|(255&i[g+2])<<8|255&i[g+3];for(f=16;f<64;f++)y=((m=t[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=t[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,t[f]=(y+t[f-7]|0)+(b+t[f-16]|0);for(f=0;f<64;f++)y=(((h>>>6|h<<26)^(h>>>11|h<<21)^(h>>>25|h<<7))+(h&u^~h&d)|0)+(p+(e[f]+t[f]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=u,u=h,h=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=h,n[5]+=u,n[6]+=d,n[7]+=p,r+=64,o-=64}return r}var i=function(){function e(){this.digestLength=t.digestLength,this.blockSize=t.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return e.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},e.prototype.clean=function(){for(var t=0;t<this.buffer.length;t++)this.buffer[t]=0;for(t=0;t<this.temp.length;t++)this.temp[t]=0;this.reset()},e.prototype.update=function(t,e){if(void 0===e&&(e=t.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=e,this.bufferLength>0){for(;this.bufferLength<64&&e>0;)this.buffer[this.bufferLength++]=t[i++],e--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(e>=64&&(i=n(this.temp,this.state,t,i,e),e%=64);e>0;)this.buffer[this.bufferLength++]=t[i++],e--;return this},e.prototype.finish=function(t){if(!this.finished){var e=this.bytesHashed,i=this.bufferLength,r=e/536870912|0,o=e<<3,s=e%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=r>>>24&255,this.buffer[s-7]=r>>>16&255,this.buffer[s-6]=r>>>8&255,this.buffer[s-5]=r>>>0&255,this.buffer[s-4]=o>>>24&255,this.buffer[s-3]=o>>>16&255,this.buffer[s-2]=o>>>8&255,this.buffer[s-1]=o>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)t[4*a+0]=this.state[a]>>>24&255,t[4*a+1]=this.state[a]>>>16&255,t[4*a+2]=this.state[a]>>>8&255,t[4*a+3]=this.state[a]>>>0&255;return this},e.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},e.prototype._saveState=function(t){for(var e=0;e<this.state.length;e++)t[e]=this.state[e]},e.prototype._restoreState=function(t,e){for(var n=0;n<this.state.length;n++)this.state[n]=t[n];this.bytesHashed=e,this.finished=!1,this.bufferLength=0},e}();t.Hash=i;var r=function(){function t(t){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var e=new Uint8Array(this.blockSize);if(t.length>this.blockSize)(new i).update(t).finish(e).clean();else for(var n=0;n<t.length;n++)e[n]=t[n];for(n=0;n<e.length;n++)e[n]^=54;for(this.inner.update(e),n=0;n<e.length;n++)e[n]^=106;for(this.outer.update(e),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<e.length;n++)e[n]=0}return t.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},t.prototype.clean=function(){for(var t=0;t<this.istate.length;t++)this.ostate[t]=this.istate[t]=0;this.inner.clean(),this.outer.clean()},t.prototype.update=function(t){return this.inner.update(t),this},t.prototype.finish=function(t){return this.outer.finished?this.outer.finish(t):(this.inner.finish(t),this.outer.update(t,this.digestLength).finish(t)),this},t.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},t}();function o(t){var e=(new i).update(t),n=e.digest();return e.clean(),n}function s(t,e){var n=new r(t).update(e),i=n.digest();return n.clean(),i}function a(t,e,n,i){var r=i[0];if(0===r)throw new Error("hkdf: cannot expand more");e.reset(),r>1&&e.update(t),n&&e.update(n),e.update(i),e.finish(t),i[0]++}t.HMAC=r,t.hash=o,t.default=o,t.hmac=s;var l=new Uint8Array(t.digestLength);t.hkdf=function(t,e,n,i){void 0===e&&(e=l),void 0===i&&(i=32);for(var o=new Uint8Array([1]),c=s(e,t),h=new r(c),u=new Uint8Array(h.digestLength),d=u.length,p=new Uint8Array(i),m=0;m<i;m++)d===u.length&&(a(u,h,n,o),d=0),p[m]=u[d++];return h.clean(),u.fill(0),o.fill(0),p},t.pbkdf2=function(t,e,n,i){for(var o=new r(t),s=o.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),h=new Uint8Array(i),u=0;u*s<i;u++){var d=u+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,o.reset(),o.update(e),o.update(a),o.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){o.reset(),o.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&u*s+p<i;p++)h[u*s+p]=l[p]}for(u=0;u<s;u++)l[u]=c[u]=0;for(u=0;u<4;u++)a[u]=0;return o.clean(),h}}(e);var r=e.default;for(var o in e)r[o]=e[o];"object"==typeof t.exports?t.exports=r:void 0===(i=function(){return r}.call(e,n,e,t))||(t.exports=i)}()},2787:(t,e,n)=>{"use strict";n.d(e,{I:()=>r});const i=new Uint32Array(65536),r=(t,e)=>{if(t.length<e.length){const n=e;e=t,t=n}return 0===e.length?t.length:t.length<=32?((t,e)=>{const n=t.length,r=e.length,o=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[t.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let t=i[e.charCodeAt(c)];const n=t|a;t|=(t&s)+s^s,a|=~(t|s),s&=t,a&o&&l++,s&o&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[t.charCodeAt(c)]=0;return l})(t,e):((t,e)=>{const n=e.length,r=t.length,o=[],s=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let t=0;t<a;t++)s[t]=-1,o[t]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const h=32*c,u=Math.min(32,r)+h;for(let e=h;e<u;e++)i[t.charCodeAt(e)]|=1<<e;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],r=s[t/32|0]>>>t&1,c=o[t/32|0]>>>t&1,h=n|a,u=((n|c)&l)+l^l|n|c;let d=a|~(u|l),p=l&u;d>>>31^r&&(s[t/32|0]^=1<<t),p>>>31^c&&(o[t/32|0]^=1<<t),d=d<<1|r,p=p<<1|c,l=p|~(h|d),a=d&h}for(let e=h;e<u;e++)i[t.charCodeAt(e)]=0}let h=0,u=-1;const d=32*c,p=Math.min(32,r-d)+d;for(let e=d;e<p;e++)i[t.charCodeAt(e)]|=1<<e;let m=r;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],a=s[t/32|0]>>>t&1,l=o[t/32|0]>>>t&1,c=n|h,d=((n|l)&u)+u^u|n|l;let p=h|~(d|u),f=u&d;m+=p>>>r-1&1,m-=f>>>r-1&1,p>>>31^a&&(s[t/32|0]^=1<<t),f>>>31^l&&(o[t/32|0]^=1<<t),p=p<<1|a,f=f<<1|l,u=f|~(c|p),h=p&c}for(let e=d;e<p;e++)i[t.charCodeAt(e)]=0;return m})(t,e)}},9937:t=>{t.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(t,e)=>{e.assign=function(t){t=t||{};var e,n,i,r=Array.prototype.slice.call(arguments).slice(1);for(e=0,i=r.length;e<i;e++)if(r[e])for(n in r[e])t[n]=r[e][n];return t},e.validateSettings=function(t){return"linLogMode"in t&&"boolean"!=typeof t.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in t&&"boolean"!=typeof t.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in t&&"boolean"!=typeof t.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in t&&"number"!=typeof t.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in t)||"number"==typeof t.scalingRatio&&t.scalingRatio>=0?"strongGravityMode"in t&&"boolean"!=typeof t.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in t)||"number"==typeof t.gravity&&t.gravity>=0?"slowDown"in t&&!("number"==typeof t.slowDown||t.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in t&&"boolean"!=typeof t.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in t)||"number"==typeof t.barnesHutTheta&&t.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},e.graphToByteArrays=function(t,e){var n,i=t.order,r=t.size,o={},s=new Float32Array(10*i),a=new Float32Array(3*r);return n=0,t.forEachNode((function(t,e){o[t]=n,s[n]=e.x,s[n+1]=e.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=e.size||1,s[n+9]=e.fixed?1:0,n+=10})),n=0,t.forEachEdge((function(t,i,r,l,c,h,u){var d=o[r],p=o[l],m=e(t,i,r,l,c,h,u);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},e.assignLayoutChanges=function(t,e,n){var i=0;t.updateEachNodeAttributes((function(t,r){return r.x=e[i],r.y=e[i+1],i+=10,n?n(t,r):r}))},e.readGraphPositions=function(t,e){var n=0;t.forEachNode((function(t,i){e[n]=i.x,e[n+1]=i.y,n+=10}))},e.collectLayoutChanges=function(t,e,n){for(var i=t.nodes(),r={},o=0,s=0,a=e.length;o<a;o+=10){if(n){var l=Object.assign({},t.getNodeAttributes(i[s]));l.x=e[o],l.y=e[o+1],l=n(i[s],l),r[i[s]]={x:l.x,y:l.y}}else r[i[s]]={x:e[o],y:e[o+1]};s++}return r},e.createWorker=function(t){var e=window.URL||window.webkitURL,n=t.toString(),i=e.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),r=new Worker(i);return e.revokeObjectURL(i),r}},8903:(t,e,n)=>{var i=n(1736),r=n(8153).Fd,o=n(2561),s=n(1782),a=n(9937);function l(t,e,n){if(!i(e))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=r("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,h="function"==typeof n.outputReducer?n.outputReducer:null,u=s.assign({},a,n.settings),d=s.validateSettings(u);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(e,c);for(p=0;p<l;p++)o(u,m.nodes,m.edges);if(!t)return s.collectLayoutChanges(e,m.nodes);s.assignLayoutChanges(e,m.nodes,h)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(t){var e="number"==typeof t?t:t.order;return{barnesHutOptimize:e>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(e)}},t.exports=c},2561:t=>{var e=10;t.exports=function(t,n,i){var r,o,s,a,l,c,h,u,d,p,m,f,g,y,b,v,w,C,A,S,x,E,M,_=n.length,I=i.length,T=t.adjustSizes,L=t.barnesHutTheta*t.barnesHutTheta,N=[];for(s=0;s<_;s+=e)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(t.outboundAttractionDistribution){for(m=0,s=0;s<_;s+=e)m+=n[s+6];m/=_/e}if(t.barnesHutOptimize){var P,$,R,O=1/0,k=-1/0,G=1/0,F=-1/0;for(s=0;s<_;s+=e)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),G=Math.min(G,n[s+1]),F=Math.max(F,n[s+1]);var H=k-O,B=F-G;for(H>B?F=(G-=(H-B)/2)+H:k=(O-=(B-H)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+F)/2,N[3]=Math.max(k-O,F-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,r=1,s=0;s<_;s+=e)for(o=0,R=3;;){if(!(N[o+5]>=0)){if(N[o+0]<0){N[o+0]=s;break}if(N[o+5]=9*r,u=N[o+3]/2,N[(d=N[o+5])+0]=-1,N[d+1]=N[o+1]-u,N[d+2]=N[o+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]-u,N[d+2]=N[o+2]+u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+u,N[d+2]=N[o+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+u,N[d+2]=N[o+2]+u,N[d+3]=u,N[d+4]=N[o+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,r+=4,P=n[N[o+0]+0]<N[o+1]?n[N[o+0]+1]<N[o+2]?N[o+5]:N[o+5]+9:n[N[o+0]+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+6]=n[N[o+0]+6],N[o+7]=n[N[o+0]+0],N[o+8]=n[N[o+0]+1],N[P+0]=N[o+0],N[o+0]=-1,P===($=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27)){if(R--){o=P;continue}R=3;break}N[$+0]=s;break}P=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+7]=(N[o+7]*N[o+6]+n[s+0]*n[s+6])/(N[o+6]+n[s+6]),N[o+8]=(N[o+8]*N[o+6]+n[s+1]*n[s+6])/(N[o+6]+n[s+6]),N[o+6]+=n[s+6],o=P}}if(t.barnesHutOptimize){for(f=t.scalingRatio,s=0;s<_;s+=e)for(o=0;;)if(N[o+5]>=0){if(v=Math.pow(n[s+0]-N[o+7],2)+Math.pow(n[s+1]-N[o+8],2),4*(p=N[o+3])*p/v<L){if(g=n[s+0]-N[o+7],y=n[s+1]-N[o+8],!0===T?v>0?(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*N[o+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w),(o=N[o+4])<0)break;continue}o=N[o+5]}else if((c=N[o+0])>=0&&c!==s&&(v=(g=n[s+0]-n[c+0])*g+(y=n[s+1]-n[c+1])*y,!0===T?v>0?(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w)),(o=N[o+4])<0)break}else for(f=t.scalingRatio,a=0;a<_;a+=e)for(l=0;l<a;l+=e)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=t.gravity/t.scalingRatio,f=t.scalingRatio,s=0;s<_;s+=e)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(t.outboundAttractionDistribution?m:1),h=0;h<I;h+=3)a=i[h+0],l=i[h+1],u=i[h+2],b=Math.pow(u,t.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===T)for(s=0;s<_;s+=e)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=M);else for(s=0;s<_;s+=e)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=M);return{}}},8153:(t,e)=>{function n(t){return"number"!=typeof t||isNaN(t)?1:t}e.Fd=function(t){return function(t,e){var n={},i=function(t){return void 0===t?e:t};"function"==typeof e&&(i=e);var r=function(e){return i(e[t])},o=function(){return i(void 0)};return"string"==typeof t?(n.fromAttributes=r,n.fromGraph=function(t,e){return r(t.getEdgeAttributes(e))},n.fromEntry=function(t,e){return r(e)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof t?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(e,n){var r=e.extremities(n);return i(t(n,e.getEdgeAttributes(n),r[0],r[1],e.getNodeAttributes(r[0]),e.getNodeAttributes(r[1]),e.isUndirected(n)))},n.fromEntry=function(e,n,r,o,s,a,l){return i(t(e,n,r,o,s,a,l))},n.fromPartialEntry=function(e,n,r,o){return i(t(e,n,r,o))},n.fromMinimalEntry=function(e,n){return i(t(e,n))}):(n.fromAttributes=o,n.fromGraph=o,n.fromEntry=o,n.fromMinimalEntry=o),n}(t,n)}},1736:t=>{t.exports=function(t){return null!==t&&"object"==typeof t&&"function"==typeof t.addUndirectedEdgeWithKey&&"function"==typeof t.dropNode&&"boolean"==typeof t.multi}},934:function(t){t.exports=function(){"use strict";function t(e){return(t="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(e)}function e(t,e){t.prototype=Object.create(e.prototype),t.prototype.constructor=t,i(t,e)}function n(t){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(t){return t.__proto__||Object.getPrototypeOf(t)},n(t)}function i(t,e){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(t,e){return t.__proto__=e,t},i(t,e)}function r(t,e,n){return r=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(t){return!1}}()?Reflect.construct.bind():function(t,e,n){var r=[null];r.push.apply(r,e);var o=new(Function.bind.apply(t,r));return n&&i(o,n.prototype),o},r.apply(null,arguments)}function o(t){var e="function"==typeof Map?new Map:void 0;return o=function(t){if(null===t||(o=t,-1===Function.toString.call(o).indexOf("[native code]")))return t;var o;if("function"!=typeof t)throw new TypeError("Super expression must either be null or a function");if(void 0!==e){if(e.has(t))return e.get(t);e.set(t,s)}function s(){return r(t,arguments,n(this).constructor)}return s.prototype=Object.create(t.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,t)},o(t)}function s(t){if(void 0===t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return t}var a=function(){for(var t=arguments[0],e=1,n=arguments.length;e<n;e++)if(arguments[e])for(var i in arguments[e])t[i]=arguments[e][i];return t};function l(t,e,n,i){var r=t._nodes.get(e),o=null;return r?o="mixed"===i?r.out&&r.out[n]||r.undirected&&r.undirected[n]:"directed"===i?r.out&&r.out[n]:r.undirected&&r.undirected[n]:o}function c(e){return"object"===t(e)&&null!==e}function h(t){var e;for(e in t)return!1;return!0}function u(t,e,n){Object.defineProperty(t,e,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(t,e,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(t,e,i)}function p(t){return!(!c(t)||t.attributes&&!Array.isArray(t.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(t,e,n){return Function.prototype.apply.call(t,e,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(t){return Object.getOwnPropertyNames(t).concat(Object.getOwnPropertySymbols(t))}:function(t){return Object.getOwnPropertyNames(t)};var b=Number.isNaN||function(t){return t!=t};function v(){v.init.call(this)}f.exports=v,f.exports.once=function(t,e){return new Promise((function(n,i){function r(n){t.removeListener(e,o),i(n)}function o(){"function"==typeof t.removeListener&&t.removeListener("error",r),n([].slice.call(arguments))}T(t,e,o,{once:!0}),"error"!==e&&function(t,e){"function"==typeof t.on&&T(t,"error",e,{once:!0})}(t,r)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(t){if("function"!=typeof t)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof t)}function A(t){return void 0===t._maxListeners?v.defaultMaxListeners:t._maxListeners}function S(t,e,n,i){var r,o,s,a;if(C(n),void 0===(o=t._events)?(o=t._events=Object.create(null),t._eventsCount=0):(void 0!==o.newListener&&(t.emit("newListener",e,n.listener?n.listener:n),o=t._events),s=o[e]),void 0===s)s=o[e]=n,++t._eventsCount;else if("function"==typeof s?s=o[e]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(r=A(t))>0&&s.length>r&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(e)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=t,l.type=e,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return t}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(t,e,n){var i={fired:!1,wrapFn:void 0,target:t,type:e,listener:n},r=x.bind(i);return r.listener=n,i.wrapFn=r,r}function M(t,e,n){var i=t._events;if(void 0===i)return[];var r=i[e];return void 0===r?[]:"function"==typeof r?n?[r.listener||r]:[r]:n?function(t){for(var e=new Array(t.length),n=0;n<e.length;++n)e[n]=t[n].listener||t[n];return e}(r):I(r,r.length)}function _(t){var e=this._events;if(void 0!==e){var n=e[t];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(t,e){for(var n=new Array(e),i=0;i<e;++i)n[i]=t[i];return n}function T(t,e,n,i){if("function"==typeof t.on)i.once?t.once(e,n):t.on(e,n);else{if("function"!=typeof t.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof t);t.addEventListener(e,(function r(o){i.once&&t.removeEventListener(e,r),n(o)}))}}function L(t){if("function"!=typeof t)throw new Error("obliterator/iterator: expecting a function!");this.next=t}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+t+".");w=t}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+t+".");return this._maxListeners=t,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(t){for(var e=[],n=1;n<arguments.length;n++)e.push(arguments[n]);var i="error"===t,r=this._events;if(void 0!==r)i=i&&void 0===r.error;else if(!i)return!1;if(i){var o;if(e.length>0&&(o=e[0]),o instanceof Error)throw o;var s=new Error("Unhandled error."+(o?" ("+o.message+")":""));throw s.context=o,s}var a=r[t];if(void 0===a)return!1;if("function"==typeof a)y(a,this,e);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,e)}return!0},v.prototype.addListener=function(t,e){return S(this,t,e,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(t,e){return S(this,t,e,!0)},v.prototype.once=function(t,e){return C(e),this.on(t,E(this,t,e)),this},v.prototype.prependOnceListener=function(t,e){return C(e),this.prependListener(t,E(this,t,e)),this},v.prototype.removeListener=function(t,e){var n,i,r,o,s;if(C(e),void 0===(i=this._events))return this;if(void 0===(n=i[t]))return this;if(n===e||n.listener===e)0==--this._eventsCount?this._events=Object.create(null):(delete i[t],i.removeListener&&this.emit("removeListener",t,n.listener||e));else if("function"!=typeof n){for(r=-1,o=n.length-1;o>=0;o--)if(n[o]===e||n[o].listener===e){s=n[o].listener,r=o;break}if(r<0)return this;0===r?n.shift():function(t,e){for(;e+1<t.length;e++)t[e]=t[e+1];t.pop()}(n,r),1===n.length&&(i[t]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",t,s||e)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(t){var e,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[t]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[t]),this;if(0===arguments.length){var r,o=Object.keys(n);for(i=0;i<o.length;++i)"removeListener"!==(r=o[i])&&this.removeAllListeners(r);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(e=n[t]))this.removeListener(t,e);else if(void 0!==e)for(i=e.length-1;i>=0;i--)this.removeListener(t,e[i]);return this},v.prototype.listeners=function(t){return M(this,t,!0)},v.prototype.rawListeners=function(t){return M(this,t,!1)},v.listenerCount=function(t,e){return"function"==typeof t.listenerCount?t.listenerCount(e):_.call(t,e)},v.prototype.listenerCount=_,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var t=arguments,e=t.length,n=0;return new L((function(){return n>=e?{done:!0}:{done:!1,value:t[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(t){var e=0,n=t.length;return new L((function(){return e>=n?{done:!0}:{done:!1,value:t[e++]}}))},L.is=function(t){return t instanceof L||"object"==typeof t&&null!==t&&"function"==typeof t.next};var N=L,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var $=N,R=P,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(t){var e=function(t){return"string"==typeof t||Array.isArray(t)||O&&ArrayBuffer.isView(t)?$.fromSequence(t):"object"!=typeof t||null===t?null:k&&"function"==typeof t[Symbol.iterator]?t[Symbol.iterator]():"function"==typeof t.next?t:null}(t);if(!e)throw new Error("obliterator: target is not iterable nor a valid iterator.");return e},F=G,H=function(t,e){for(var n,i=arguments.length>1?e:1/0,r=i!==1/0?new Array(i):[],o=0,s=F(t);;){if(o===i)return r;if((n=s.next()).done)return o!==e&&(r.length=o),r;r[o++]=n.value}},B=function(t){function n(e){var n;return(n=t.call(this)||this).name="GraphError",n.message=e,n}return e(n,t),n}(o(Error)),D=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B),V=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B),j=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B);function U(t,e){this.key=t,this.attributes=e,this.clear()}function W(t,e){this.key=t,this.attributes=e,this.clear()}function q(t,e){this.key=t,this.attributes=e,this.clear()}function z(t,e,n,i,r){this.key=e,this.attributes=r,this.undirected=t,this.source=n,this.target=i}function Y(t,e,n,i,r,o,s){var a,l,c,h;if(i=""+i,0===n){if(!(a=t._nodes.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" node in the graph.'));c=r,h=o}else if(3===n){if(r=""+r,!(l=t._edges.get(r)))throw new V("Graph.".concat(e,': could not find the "').concat(r,'" edge in the graph.'));var u=l.source.key,d=l.target.key;if(i===u)a=l.target;else{if(i!==d)throw new V("Graph.".concat(e,': the "').concat(i,'" node is not attached to the "').concat(r,'" edge (').concat(u,", ").concat(d,")."));a=l.source}c=o,h=s}else{if(!(l=t._edges.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=r,h=o}return[a,c,h]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},q.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var t="out",e="in";this.undirected&&(t=e="undirected");var n=this.source.key,i=this.target.key;this.source[t][i]=this,this.undirected&&n===i||(this.target[e][n]=this)},z.prototype.attachMulti=function(){var t="out",e="in",n=this.source.key,i=this.target.key;this.undirected&&(t=e="undirected");var r=this.source[t],o=r[i];if(void 0===o)return r[i]=this,void(this.undirected&&n===i||(this.target[e][n]=this));o.previous=this,this.next=o,r[i]=this,this.target[e][n]=this},z.prototype.detach=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][e],delete this.target[i][t]},z.prototype.detachMulti=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][e],delete this.target[i][t]):(this.next.previous=void 0,this.source[n][e]=this.next,this.target[i][t]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return s.attributes[a]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){return Y(this,e,n,t,i)[0].attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return s.attributes.hasOwnProperty(a)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r,o){var s=Y(this,e,n,t,i,r,o),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r,o){var s=Y(this,e,n,t,i,r,o),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new D("Graph.".concat(e,": updater should be a function."));var h=a.attributes,u=c(h[l]);return h[l]=u,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];if(!c(a))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],l=o[1];if(!c(l))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];if("function"!=typeof a)throw new D("Graph.".concat(e,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return r.attributes[i]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,o=""+arguments[1];if(!(i=l(this,r,o,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(i=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return i.attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return r.attributes.hasOwnProperty(i)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return o.attributes[i]=r,this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof r)throw new D("Graph.".concat(e,": updater should be a function."));return o.attributes[i]=r(o.attributes[i]),this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return delete r.attributes[i],this.emit("edgeAttributesUpdated",{key:r.key,type:"remove",attributes:r.attributes,name:i}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return r.attributes=i,this.emit("edgeAttributesUpdated",{key:r.key,type:"replace",attributes:r.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return a(r.attributes,i),this.emit("edgeAttributesUpdated",{key:r.key,type:"merge",attributes:r.attributes,data:i}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(e,": provided updater is not a function."));return r.attributes=i(r.attributes),this.emit("edgeAttributesUpdated",{key:r.key,type:"update",attributes:r.attributes}),this}}}],X=N,J=G,Q=function(){var t=arguments,e=null,n=-1;return new X((function(){for(var i=null;;){if(null===e){if(++n>=t.length)return{done:!0};e=J(t[n])}if(!0!==(i=e.next()).done)break;e=null}return i}))},tt=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function et(t,e,n,i){var r=!1;for(var o in e)if(o!==i){var s=e[o];if(r=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),t&&r)return s.key}}function nt(t,e,n,i){var r,o,s,a=!1;for(var l in e)if(l!==i){r=e[l];do{if(o=r.source,s=r.target,a=n(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected),t&&a)return r.key;r=r.next}while(void 0!==r)}}function it(t,e){var n,i=Object.keys(t),r=i.length,o=0;return new N((function(){do{if(n)n=n.next;else{if(o>=r)return{done:!0};var s=i[o++];if(s===e){n=void 0;continue}n=t[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function rt(t,e,n,i){var r=e[n];if(r){var o=r.source,s=r.target;return i(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected)&&t?r.key:void 0}}function ot(t,e,n,i){var r=e[n];if(r){var o=!1;do{if(o=i(r.key,r.attributes,r.source.key,r.target.key,r.source.attributes,r.target.attributes,r.undirected),t&&o)return r.key;r=r.next}while(void 0!==r)}}function st(t,e){var n=t[e];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var t={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:t}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function at(t,e,n,i){if(0!==e.size)for(var r,o,s="mixed"!==n&&n!==e.type,a="undirected"===n,l=!1,c=e._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var h=o,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,o.undirected),t&&l)return u}}function lt(t,e,n,i,r,o){var s,a=e?nt:et;if("undirected"!==n){if("out"!==i&&(s=a(t,r.in,o),t&&s))return s;if("in"!==i&&(s=a(t,r.out,o,i?void 0:r.key),t&&s))return s}if("directed"!==n&&(s=a(t,r.undirected,o),t&&s))return s}function ct(t,e,n,i,r,o,s){var a,l=n?ot:rt;if("undirected"!==e){if(void 0!==r.in&&"out"!==i&&(a=l(t,r.in,o,s),t&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(t,r.out,o,s),t&&a))return a}if("directed"!==e&&void 0!==r.undirected&&(a=l(t,r.undirected,o,s),t&&a))return a}var ht=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ut(){this.A=null,this.B=null}function dt(t,e,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!e||!e.has(c.key)){var h=r(c.key,c.attributes);if(t&&h)return c.key}}}function pt(t,e,n,i,r){if("mixed"!==e){if("undirected"===e)return dt(t,null,i,i.undirected,r);if("string"==typeof n)return dt(t,null,i,i[n],r)}var o,s=new ut;if("undirected"!==e){if("out"!==n){if(o=dt(t,null,i,i.in,r),t&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=dt(t,s,i,i.out,r),t&&o)return o;s.wrap(i.out)}}if("directed"!==e&&(o=dt(t,s,i,i.undirected,r),t&&o))return o}function mt(t,e,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return t&&t.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===e?c:l,t&&t.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ft(t,e,n,i,r){for(var o,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(e&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=r(s.key,null,s.attributes,null,null,null,null),t&&u))return null}}function gt(t){if(!c(t))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in t))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function yt(t){if(!c(t))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in t))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in t))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in t&&"boolean"!=typeof t.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ut.prototype.wrap=function(t){null===this.A?this.A=t:null===this.B&&(this.B=t)},ut.prototype.has=function(t){return null!==this.A&&t in this.A||null!==this.B&&t in this.B};var bt,vt=(bt=255&Math.floor(256*Math.random()),function(){return bt++}),wt=new Set(["directed","undirected","mixed"]),Ct=new Set(["domain","_events","_eventsCount","_maxListeners"]),At={allowSelfLoops:!0,multi:!1,type:"mixed"};function St(t,e,n){var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}function xt(t,e,n,i,r,o,s,a){if(!i&&"undirected"===t.type)throw new j("Graph.".concat(e,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new j("Graph.".concat(e,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!t.allowSelfLoops&&o===s)throw new j("Graph.".concat(e,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=t._nodes.get(o),h=t._nodes.get(s);if(!l)throw new V("Graph.".concat(e,': source node "').concat(o,'" not found.'));if(!h)throw new V("Graph.".concat(e,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=t._edgeKeyGenerator();else if(r=""+r,t._edges.has(r))throw new j("Graph.".concat(e,': the "').concat(r,'" edge already exists in the graph.'));if(!t.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(e,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,r,l,h,a);t._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,t._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,u.key=r,t.emit("edgeAdded",u),r}function Et(t,e,n,i,r,o,s,l,h){if(!i&&"undirected"===t.type)throw new j("Graph.".concat(e,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new j("Graph.".concat(e,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(e,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(o=""+o,s=""+s,h&&(u=l,l=void 0),!t.allowSelfLoops&&o===s)throw new j("Graph.".concat(e,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=t._nodes.get(o),f=t._nodes.get(s);if(!n&&(d=t._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(e,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||t.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),t.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),t.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=t._edgeKeyGenerator();else if(r=""+r,t._edges.has(r))throw new j("Graph.".concat(e,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=St(t,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=St(t,s,{}),w=!0),d=new z(i,r,m,f,l),t._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,t._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,b.key=r,t.emit("edgeAdded",b),[r,!0,v,w]}function Mt(t,e){t._edges.delete(e.key);var n=e.source,i=e.target,r=e.attributes,o=e.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,t._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,t._directedSelfLoopCount--)),t.multi?e.detachMulti():e.detach(),o?t._undirectedSize--:t._directedSize--,t.emit("edgeDropped",{key:e.key,attributes:r,source:n.key,target:i.key,undirected:o})}var _t=function(n){function i(t){var e;if(e=n.call(this)||this,"boolean"!=typeof(t=a({},At,t)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(t.multi,'".'));if(!wt.has(t.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(t.type,'".'));if("boolean"!=typeof t.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(t.allowSelfLoops,'".'));var i="mixed"===t.type?U:"directed"===t.type?W:q;u(s(e),"NodeDataClass",i);var r="geid_"+vt()+"_",o=0;return u(s(e),"_attributes",{}),u(s(e),"_nodes",new Map),u(s(e),"_edges",new Map),u(s(e),"_directedSize",0),u(s(e),"_undirectedSize",0),u(s(e),"_directedSelfLoopCount",0),u(s(e),"_undirectedSelfLoopCount",0),u(s(e),"_edgeKeyGenerator",(function(){var t;do{t=r+o++}while(e._edges.has(t));return t})),u(s(e),"_options",t),Ct.forEach((function(t){return u(s(e),t,e[t])})),d(s(e),"order",(function(){return e._nodes.size})),d(s(e),"size",(function(){return e._edges.size})),d(s(e),"directedSize",(function(){return e._directedSize})),d(s(e),"undirectedSize",(function(){return e._undirectedSize})),d(s(e),"selfLoopCount",(function(){return e._directedSelfLoopCount+e._undirectedSelfLoopCount})),d(s(e),"directedSelfLoopCount",(function(){return e._directedSelfLoopCount})),d(s(e),"undirectedSelfLoopCount",(function(){return e._undirectedSelfLoopCount})),d(s(e),"multi",e._options.multi),d(s(e),"type",e._options.type),d(s(e),"allowSelfLoops",e._options.allowSelfLoops),d(s(e),"implementation",(function(){return"graphology"})),e}e(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(t){return this._nodes.has(""+t)},r.hasDirectedEdge=function(t,e){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){t=""+t,e=""+e;var r=this._nodes.get(t);return!!r&&r.out.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(t,e){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){t=""+t,e=""+e;var r=this._nodes.get(t);return!!r&&r.undirected.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(t,e){if(1===arguments.length){var n=""+t;return this._edges.has(n)}if(2===arguments.length){t=""+t,e=""+e;var i=this._nodes.get(t);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(e)||void 0!==i.undirected&&i.undirected.hasOwnProperty(e))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(t,e){if("undirected"!==this.type){if(t=""+t,e=""+e,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.directedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(t,e){if("directed"!==this.type){if(t=""+t,e=""+e,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.undirected&&n.undirected[e]||void 0;return i?i.key:void 0}},r.edge=function(t,e){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.edge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.edge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||n.undirected&&n.undirected[e]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)},r.areOutNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out},r.areInNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in},r.areUndirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"directed"!==this.type&&e in n.undirected},r.areNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)||"directed"!==this.type&&e in n.undirected},r.areInboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in||"directed"!==this.type&&e in n.undirected},r.areOutboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out||"directed"!==this.type&&e in n.undirected},r.inDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree},r.outDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree},r.directedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree},r.undirectedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegree: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree},r.inboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree),n},r.outboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.outDegree),n},r.degree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree),n},r.inDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree-e.directedLoops},r.outDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree-e.directedLoops},r.directedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree-2*e.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree-2*e.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree,i+=e.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.outDegree,i+=e.directedLoops),n-i},r.degreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree,i+=2*e.directedLoops),n-i},r.source=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.source: could not find the "'.concat(t,'" edge in the graph.'));return e.source.key},r.target=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.target: could not find the "'.concat(t,'" edge in the graph.'));return e.target.key},r.extremities=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.extremities: could not find the "'.concat(t,'" edge in the graph.'));return[e.source.key,e.target.key]},r.opposite=function(t,e){t=""+t,e=""+e;var n=this._edges.get(e);if(!n)throw new V('Graph.opposite: could not find the "'.concat(e,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(t===i)return r;if(t===r)return i;throw new V('Graph.opposite: the "'.concat(t,'" node is not attached to the "').concat(e,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(t,e){t=""+t,e=""+e;var n=this._edges.get(t);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(t,'" edge in the graph.'));return n.source.key===e||n.target.key===e},r.isUndirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isUndirected: could not find the "'.concat(t,'" edge in the graph.'));return e.undirected},r.isDirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isDirected: could not find the "'.concat(t,'" edge in the graph.'));return!e.undirected},r.isSelfLoop=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isSelfLoop: could not find the "'.concat(t,'" edge in the graph.'));return e.source===e.target},r.addNode=function(t,e){var n=function(t,e,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(e=""+e,n=n||{},t._nodes.has(e))throw new j('Graph.addNode: the "'.concat(e,'" node already exist in the graph.'));var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}(this,t,e);return n.key},r.mergeNode=function(t,e){if(e&&!c(e))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(e,'"'));t=""+t,e=e||{};var n=this._nodes.get(t);return n?(e&&(a(n.attributes,e),this.emit("nodeAttributesUpdated",{type:"merge",key:t,attributes:n.attributes,data:e})),[t,!1]):(n=new this.NodeDataClass(t,e),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:e}),[t,!0])},r.updateNode=function(t,e){if(e&&"function"!=typeof e)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(e,'"'));t=""+t;var n=this._nodes.get(t);if(n){if(e){var i=n.attributes;n.attributes=e(i),this.emit("nodeAttributesUpdated",{type:"replace",key:t,attributes:n.attributes})}return[t,!1]}var r=e?e({}):{};return n=new this.NodeDataClass(t,r),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:r}),[t,!0]},r.dropNode=function(t){t=""+t;var e,n=this._nodes.get(t);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(t,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){e=n.out[i];do{Mt(this,e),e=e.next}while(e)}for(var r in n.in){e=n.in[r];do{Mt(this,e),e=e.next}while(e)}}if("directed"!==this.type)for(var o in n.undirected){e=n.undirected[o];do{Mt(this,e),e=e.next}while(e)}this._nodes.delete(t),this.emit("nodeDropped",{key:t,attributes:n.attributes})},r.dropEdge=function(t){var e;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(e=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(t=""+t,!(e=this._edges.get(t)))throw new V('Graph.dropEdge: could not find the "'.concat(t,'" edge in the graph.'));return Mt(this,e),this},r.dropDirectedEdge=function(t,e){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t=""+t,e=""+e,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},r.dropUndirectedEdge=function(t,e){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t,e,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var t,e=this._nodes.values();!0!==(t=e.next()).done;)t.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(t){return this._attributes[t]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(t){return this._attributes.hasOwnProperty(t)},r.setAttribute=function(t,e){return this._attributes[t]=e,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},r.updateAttribute=function(t,e){if("function"!=typeof e)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[t];return this._attributes[t]=e(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},r.removeAttribute=function(t){return delete this._attributes[t],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:t}),this},r.replaceAttributes=function(t){if(!c(t))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=t,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(t){if(!c(t))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,t),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:t}),this},r.updateAttributes=function(t){if("function"!=typeof t)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=t(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=t(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:e||null})},r.updateEachEdgeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=t(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:e||null})},r.forEachAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ft(!1,!1,!1,this,t)},r.forEachAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!1,!0,this,t)},r.forEachAssymetricAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ft(!1,!0,!1,this,t)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!0,!0,this,t)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(t){if("function"!=typeof t)throw new D("Graph.forEachNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)},r.findNode=function(t){if("function"!=typeof t)throw new D("Graph.findNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return n.key},r.mapNodes=function(t){if("function"!=typeof t)throw new D("Graph.mapNode: expecting a callback.");for(var e,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(e=i.next()).done;)n=e.value,r[o++]=t(n.key,n.attributes);return r},r.someNode=function(t){if("function"!=typeof t)throw new D("Graph.someNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return!0;return!1},r.everyNode=function(t){if("function"!=typeof t)throw new D("Graph.everyNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(!t((n=e.value).key,n.attributes))return!1;return!0},r.filterNodes=function(t){if("function"!=typeof t)throw new D("Graph.filterNodes: expecting a callback.");for(var e,n,i=this._nodes.values(),r=[];!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(t,e){if("function"!=typeof t)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=e,o=this._nodes.values();!0!==(n=o.next()).done;)r=t(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var t=this._nodes.values();return new N((function(){var e=t.next();if(e.done)return e;var n=e.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var t=this,e=new Array(this._nodes.size),n=0;this._nodes.forEach((function(t,i){e[n++]=function(t,e){var n={key:t};return h(e.attributes)||(n.attributes=a({},e.attributes)),n}(i,t)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(e,r){i[n++]=function(t,e,n){var i={key:e,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===t&&n.undirected&&(i.undirected=!0),i}(t.type,r,e)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:e,edges:i}},r.import=function(t){var e,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(t instanceof i)return t.forEachNode((function(t,e){l?a.mergeNode(t,e):a.addNode(t,e)})),t.forEachEdge((function(t,e,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(t,n,i,e):a.mergeDirectedEdgeWithKey(t,n,i,e):s?a.addUndirectedEdgeWithKey(t,n,i,e):a.addDirectedEdgeWithKey(t,n,i,e)})),this;if(!c(t))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(t.attributes){if(!c(t.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(t.attributes):this.replaceAttributes(t.attributes)}if(t.nodes){if(r=t.nodes,!Array.isArray(r))throw new D("Graph.import: invalid nodes. Expecting an array.");for(e=0,n=r.length;e<n;e++){gt(o=r[e]);var h=o,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(t.edges){var p=!1;if("undirected"===this.type&&(p=!0),r=t.edges,!Array.isArray(r))throw new D("Graph.import: invalid edges. Expecting an array.");for(e=0,n=r.length;e<n;e++){yt(s=r[e]);var m=s,f=m.source,g=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,f,g,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},r.nullCopy=function(t){var e=new i(a({},this._options,t));return e.replaceAttributes(a({},this.getAttributes())),e},r.emptyCopy=function(t){var e=this.nullCopy(t);return this._nodes.forEach((function(t,n){var i=a({},t.attributes);t=new e.NodeDataClass(n,i),e._nodes.set(n,t)})),e},r.copy=function(t){if("string"==typeof(t=t||{}).type&&t.type!==this.type&&"mixed"!==t.type)throw new j('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(t.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof t.multi&&t.multi!==this.multi&&!0!==t.multi)throw new j("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof t.allowSelfLoops&&t.allowSelfLoops!==this.allowSelfLoops&&!0!==t.allowSelfLoops)throw new j("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var e,n,i=this.emptyCopy(t),r=this._edges.values();!0!==(e=r.next()).done;)xt(i,"copy",!1,(n=e.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},r.toJSON=function(){return this.export()},r.toString=function(){return"[object Graph]"},r.inspect=function(){var e=this,n={};this._nodes.forEach((function(t,e){n[e]=t.attributes}));var i={},r={};this._edges.forEach((function(t,n){var o,s=t.undirected?"--":"->",a="",l=t.source.key,c=t.target.key;t.undirected&&l>c&&(o=l,l=c,c=o);var h="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?e.multi&&(void 0===r[h]?r[h]=0:r[h]++,a+="".concat(r[h],". ")):a+="[".concat(n,"]: "),i[a+=h]=t.attributes}));var o={};for(var s in this)this.hasOwnProperty(s)&&!Ct.has(s)&&"function"!=typeof this[s]&&"symbol"!==t(s)&&(o[s]=this[s]);return o.attributes=this._attributes,o.nodes=n,o.edges=i,u(o,"constructor",this.constructor),o},i}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(_t.prototype[Symbol.for("nodejs.util.inspect.custom")]=_t.prototype.inspect),[{name:function(t){return"".concat(t,"Edge")},generateKey:!0},{name:function(t){return"".concat(t,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(t){return"".concat(t,"EdgeWithKey")}},{name:function(t){return"".concat(t,"DirectedEdgeWithKey")},type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(t){["add","merge","update"].forEach((function(e){var n=t.name(e),i="add"===e?xt:Et;t.generateKey?_t.prototype[n]=function(r,o,s){return i(this,n,!0,"undirected"===(t.type||this.type),null,r,o,s,"update"===e)}:_t.prototype[n]=function(r,o,s,a){return i(this,n,!1,"undirected"===(t.type||this.type),r,o,s,a,"update"===e)}}))})),function(t){K.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Node"),0),i(t,n("Source"),1),i(t,n("Target"),2),i(t,n("Opposite"),3)}))}(_t),function(t){Z.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Edge"),"mixed"),i(t,n("DirectedEdge"),"directed"),i(t,n("UndirectedEdge"),"undirected")}))}(_t),function(t){tt.forEach((function(e){!function(t,e){var n=e.name,i=e.type,r=e.direction;t.prototype[n]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(t,e){if(0===t.size)return[];if("mixed"===e||e===t.type)return"function"==typeof Array.from?Array.from(t._edges.keys()):H(t._edges.keys(),t._edges.size);for(var n,i,r="undirected"===e?t.undirectedSize:t.directedSize,o=new Array(r),s="undirected"===e,a=t._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(o[l++]=i.key);return o}(this,i);if(1===arguments.length){t=""+t;var o=this._nodes.get(t);if(void 0===o)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n,i){var r=[];return lt(!1,t,e,n,i,(function(t){r.push(t)})),r}(this.multi,"mixed"===i?this.type:i,r,o)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(n,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(n,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i,r){var o=[];return ct(!1,t,e,n,i,r,(function(t){o.push(t)})),o}(i,this.multi,r,s,e)}throw new D("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return at(!1,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return lt(!1,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!1,i,this.multi,r,a,e,n)}throw new D("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(){var t,e=Array.prototype.slice.call(arguments),n=e.pop();if(0===e.length){var r=0;"directed"!==i&&(r+=this.undirectedSize),"undirected"!==i&&(r+=this.directedSize),t=new Array(r);var s=0;e.push((function(e,i,r,o,a,l,c){t[s++]=n(e,i,r,o,a,l,c)}))}else t=[],e.push((function(e,i,r,o,s,a,l){t.push(n(e,i,r,o,s,a,l))}));return this[o].apply(this,e),t};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop(),n=[];return t.push((function(t,i,r,o,s,a,l){e(t,i,r,o,s,a,l)&&n.push(t)})),this[o].apply(this,t),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(){var t,e,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new D("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(t=n[0],e=n[1],n=[]):3===n.length?(t=n[1],e=n[2],n=[n[0]]):4===n.length&&(t=n[2],e=n[3],n=[n[0],n[1]]);var i=e;return n.push((function(e,n,r,o,s,a,l){i=t(i,e,n,r,o,s,a,l)})),this[o].apply(this,n),i}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="find"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return at(!0,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return lt(!0,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!0,i,this.multi,r,a,e,n)}throw new D("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[s]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,r,o,s,a){return e(t,n,i,r,o,s,a)})),!!this[o].apply(this,t)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,r,o,s,a){return!e(t,n,i,r,o,s,a)})),!this[o].apply(this,t)}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n.slice(0,-1)+"Entries";t.prototype[o]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(t,e){if(0===t.size)return N.empty();var n="mixed"!==e&&e!==t.type,i="undirected"===e,r=t._edges.values();return new N((function(){for(var t,e;;){if((t=r.next()).done)return t;if(e=t.value,!n||e.undirected===i)break}return{value:{edge:e.key,attributes:e.attributes,source:e.source.key,target:e.target.key,sourceAttributes:e.source.attributes,targetAttributes:e.target.attributes,undirected:e.undirected},done:!1}}))}(this,i);if(1===arguments.length){t=""+t;var n=this._nodes.get(t);if(!n)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){var i=N.empty();return"undirected"!==t&&("out"!==e&&void 0!==n.in&&(i=Q(i,it(n.in))),"in"!==e&&void 0!==n.out&&(i=Q(i,it(n.out,e?void 0:n.key)))),"directed"!==t&&void 0!==n.undirected&&(i=Q(i,it(n.undirected))),i}(i,r,n)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i){var r=N.empty();return"undirected"!==t&&(void 0!==n.in&&"out"!==e&&i in n.in&&(r=Q(r,st(n.in,i))),void 0!==n.out&&"in"!==e&&i in n.out&&(e||n.key!==i)&&(r=Q(r,st(n.out,i)))),"directed"!==t&&void 0!==n.undirected&&i in n.undirected&&(r=Q(r,st(n.undirected,i))),r}(i,r,s,e)}throw new D("Graph.".concat(o,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e)}))}(_t),function(t){ht.forEach((function(e){(function(t,e){var n=e.name,i=e.type,r=e.direction;t.prototype[n]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return Object.keys(n.undirected);if("string"==typeof e)return Object.keys(n[e])}var i=[];return pt(!1,t,e,n,(function(t){i.push(t)})),i}("mixed"===i?this.type:i,r,e)}})(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));pt(!1,"mixed"===i?this.type:i,r,n,e)}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(t,e){var n=[];return this[o](t,(function(t,i){n.push(e(t,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(t,e){var n=[];return this[o](t,(function(t,i){e(t,i)&&n.push(t)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(t,e,n){if(arguments.length<3)throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[o](t,(function(t,n){i=e(i,t,n)})),i}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n[0].toUpperCase()+n.slice(1,-1),s="find"+o;t.prototype[s]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(t,'" node in the graph.'));return pt(!0,"mixed"===i?this.type:i,r,n,e)}};var a="some"+o;t.prototype[a]=function(t,e){return!!this[s](t,e)};var l="every"+o;t.prototype[l]=function(t,e){return!this[s](t,(function(t,n){return!e(t,n)}))}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n.slice(0,-1)+"Entries";t.prototype[o]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return mt(null,n,n.undirected);if("string"==typeof e)return mt(null,n,n[e])}var i=N.empty(),r=new ut;return"undirected"!==t&&("out"!==e&&(i=Q(i,mt(r,n,n.in))),"in"!==e&&(i=Q(i,mt(r,n,n.out)))),"directed"!==t&&(i=Q(i,mt(r,n,n.undirected))),i}("mixed"===i?this.type:i,r,e)}}(t,e)}))}(_t);var It=function(t){function n(e){var n=a({type:"directed"},e);if("multi"in n&&!1!==n.multi)throw new D("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new D('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Tt=function(t){function n(e){var n=a({type:"undirected"},e);if("multi"in n&&!1!==n.multi)throw new D("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new D('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Lt=function(t){function n(e){var n=a({multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return t.call(this,n)||this}return e(n,t),n}(_t),Nt=function(t){function n(e){var n=a({type:"directed",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new D('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Pt=function(t){function n(e){var n=a({type:"undirected",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new D('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t);function $t(t){t.from=function(e,n){var i=a({},e.options,n),r=new t(i);return r.import(e),r}}return $t(_t),$t(It),$t(Tt),$t(Lt),$t(Nt),$t(Pt),_t.Graph=_t,_t.DirectedGraph=It,_t.UndirectedGraph=Tt,_t.MultiGraph=Lt,_t.MultiDirectedGraph=Nt,_t.MultiUndirectedGraph=Pt,_t.InvalidArgumentsGraphError=D,_t.NotFoundGraphError=V,_t.UsageGraphError=j,_t}()},944:(t,e)=>{"use strict";e.Vb=void 0,e.Vb=function(t,e,n){var i=function(t,e,n){if(0===t.length||0===e.length)return 0;if(n&&!n.caseSensitive&&(t=t.toUpperCase(),e=e.toUpperCase()),t===e)return 1;for(var i=0,r=t.length,o=e.length,s=Math.floor(Math.max(r,o)/2)-1,a=new Array(r),l=new Array(o),c=0;c<r;c++)for(var h=Math.max(0,c-s);h<=Math.min(o,c+s+1);h++)if(!a[c]&&!l[h]&&t[c]===e[h]){++i,a[c]=l[h]=!0;break}if(0===i)return 0;var u=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;t.charAt(c)!==e.charAt(d++)&&u++}return(i/r+i/o+(i-(u/=2))/i)/3}(t,e,n),r=0;if(i>.7){for(var o=Math.min(t.length,e.length),s=0;t[s]===e[s]&&s<4&&s<o;)++r,s++;i+=.1*r*(1-i)}return i}},7106:t=>{"use strict";var e=t.exports=function(t,e,i){"function"==typeof e&&(i=e,e={}),n(e,"function"==typeof(i=e.cb||i)?i:i.pre||function(){},i.post||function(){},t,"",t)};function n(t,i,r,o,s,a,l,c,h,u){if(o&&"object"==typeof o&&!Array.isArray(o)){for(var d in i(o,s,a,l,c,h,u),o){var p=o[d];if(Array.isArray(p)){if(d in e.arrayKeywords)for(var m=0;m<p.length;m++)n(t,i,r,p[m],s+"/"+d+"/"+m,a,s,d,o,m)}else if(d in e.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(t,i,r,p[f],s+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,o,f)}else(d in e.keywords||t.allKeys&&!(d in e.skipKeywords))&&n(t,i,r,p,s+"/"+d,a,s,d,o)}r(o,s,a,l,c,h,u)}}e.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},e.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},e.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},e.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:t=>{"use strict";var e=[];function n(t){for(var n=-1,i=0;i<e.length;i++)if(e[i].identifier===t){n=i;break}return n}function i(t,i){for(var o={},s=[],a=0;a<t.length;a++){var l=t[a],c=i.base?l[0]+i.base:l[0],h=o[c]||0,u="".concat(c," ").concat(h);o[c]=h+1;var d=n(u),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)e[d].references++,e[d].updater(p);else{var m=r(p,i);i.byIndex=a,e.splice(a,0,{identifier:u,updater:m,references:1})}s.push(u)}return s}function r(t,e){var n=e.domAPI(e);return n.update(t),function(e){if(e){if(e.css===t.css&&e.media===t.media&&e.sourceMap===t.sourceMap&&e.supports===t.supports&&e.layer===t.layer)return;n.update(t=e)}else n.remove()}}t.exports=function(t,r){var o=i(t=t||[],r=r||{});return function(t){t=t||[];for(var s=0;s<o.length;s++){var a=n(o[s]);e[a].references--}for(var l=i(t,r),c=0;c<o.length;c++){var h=n(o[c]);0===e[h].references&&(e[h].updater(),e.splice(h,1))}o=l}}},7659:t=>{"use strict";var e={};t.exports=function(t,n){var i=function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(t){n=null}e[t]=n}return e[t]}(t);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:t=>{"use strict";t.exports=function(t){var e=document.createElement("style");return t.setAttributes(e,t.attributes),t.insert(e,t.options),e}},5056:(t,e,n)=>{"use strict";t.exports=function(t){var e=n.nc;e&&t.setAttribute("nonce",e)}},7825:t=>{"use strict";t.exports=function(t){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var e=t.insertStyleElement(t);return{update:function(n){!function(t,e,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,r&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var o=n.sourceMap;o&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(o))))," */")),e.styleTagTransform(i,t,e.options)}(e,t,n)},remove:function(){!function(t){if(null===t.parentNode)return!1;t.parentNode.removeChild(t)}(e)}}}},1113:t=>{"use strict";t.exports=function(t,e){if(e.styleSheet)e.styleSheet.cssText=t;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(t))}}},1407:(t,e,n)=>{"use strict";n.d(e,{R:()=>a});var i=n(4328),r=n(6082),o=n(439);const s=31;async function a(t,e,n=!1,o){const a=e.getSeqHandler(t);let c;o??=new Map;const h=a.isHelm()?e.getSeqMonomers(t):Object.keys(a.stats.freq).filter((t=>""!==t));for(let t=0;t<h.length;t++)o.has(h[t])||o.set(h[t],`${o.size+1}`);if(a.isHelm())c=await i.functions.call("HELM:getMolFiles",{col:t}),c=function(t,e,n=!1){const i=new Array(t.length);for(let r=0;r<t.length;r++){let o=0,a=0,l="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const c=t.get(r);o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1;const h=parseInt(c.substring(o,o+3)),u=parseInt(c.substring(o+3,o+6));l+=`M  V30 COUNTS ${h} ${u} 0 0 0\n`,l+="M  V30 BEGIN ATOM\n";for(let t=0;t<h;t++){o=c.indexOf("\n",o)+1+s,a=c.indexOf(" ",o);const i=c.substring(o,a);l+=n?`M  V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}l+="M  V30 END ATOM\n",l+="M  V30 BEGIN BOND\n";for(let t=0;t<u;t++){o=c.indexOf("\n",o)+1;const e=parseInt(c.substring(o,o+3).trim()),n=parseInt(c.substring(o+3,o+6).trim());l+=`M  V30 ${t+1} ${parseInt(c.substring(o+6,o+9).trim())} ${e} ${n}\n`}l+="M  V30 END BOND\n",l+="M  V30 END CTAB\n",l+="M  END",i[r]=l}return i}(c,o,n);else{c=new Array(t.length);for(let e=0;e<t.length;e++){const t=l(a.getSplitted(e),o,n);c[e]=t}}return r.Column.fromStrings("monomericMols",c)}function l(t,e,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let r=0;r<t.length;r++){const s=t.getCanonical(r);s!==o._S&&(i+=n?`M  V30 ${r+1} R${e.get(s)} 0.000 0.000 0 0\n`:`M  V30 ${r+1} At 0.000 0.000 0 0 MASS=${e.get(s)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M  V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}},6766:(t,e,n)=>{"use strict";n.r(e),n.d(e,{GetRegionEditor:()=>Xi,SeqActivityCliffsEditor:()=>tr,SeqPaletteCustom:()=>ji,SequenceSpaceEditor:()=>Qi,SplitToMonomersEditor:()=>Ji,SubsequenceSearchTopMenu:()=>Or,_package:()=>Di,activityCliffs:()=>dr,addCopyMenu:()=>Qr,alignSequences:()=>wr,bioSubstructureFilter:()=>Ur,bioSubstructureFilterTest:()=>Wr,compositionAnalysis:()=>Cr,compositionAnalysisWidget:()=>or,convertColumnAction:()=>Er,convertDialog:()=>xr,customSequenceCellRenderer:()=>er,demoBioActivityCliffs:()=>no,demoBioAtomicLevel:()=>io,demoBioSequenceSpace:()=>eo,demoBioSimilarityDiversity:()=>to,detectMacromoleculeProbe:()=>ao,diversitySearchTopMenu:()=>$r,diversitySearchViewer:()=>Pr,fastaSequenceCellRenderer:()=>nr,getBioLib:()=>zi,getHelmMonomers:()=>Tr,getMolFromHelm:()=>co,getMonomerLibHelper:()=>Vi,getRegion:()=>hr,getRegionApp:()=>Yr,getRegionHelmApp:()=>Kr,getRegionPanel:()=>Ki,getRegionTopMenu:()=>ur,getSeqHandler:()=>Yi,getSeqHelper:()=>lo,helmPreprocessingFunction:()=>mr,importBam:()=>Sr,importFasta:()=>Ar,initBio:()=>Wi,libraryPanel:()=>Zi,longSeqTableFasta:()=>Xr,longSeqTableHelm:()=>Jr,longSeqTableSeparator:()=>Zr,macroMolColumnPropertyPanel:()=>rr,macromoleculeDifferenceCellRenderer:()=>sr,macromoleculePreprocessingFunction:()=>pr,manageLibrariesApp:()=>Dr,manageLibrariesAppTreeBrowser:()=>Vr,manageLibrariesView:()=>Hr,manageMonomerLibraries:()=>Fr,manageMonomersView:()=>Br,monomerCellRenderer:()=>Mr,multipleSequenceAlignmentDialog:()=>vr,saveAsFasta:()=>jr,sdfToJsonLib:()=>ro,searchSubsequenceEditor:()=>Rr,separatorSequenceCellRenderer:()=>ir,seq2atomic:()=>oo,seqIdentity:()=>so,sequenceAlignment:()=>ar,sequenceIdentityScoring:()=>kr,sequenceSimilarityScoring:()=>Gr,sequenceSpaceTopMenu:()=>fr,sequenceTooltip:()=>qi,similaritySearchTopMenu:()=>Nr,similaritySearchViewer:()=>Lr,splitToMonomersTopMenu:()=>Ir,test1:()=>ho,testDetectMacromolecule:()=>_r,toAtomicLevel:()=>gr,toAtomicLevelAction:()=>yr,toAtomicLevelPanel:()=>br,vdRegionsViewer:()=>cr,webLogoAggApp:()=>zr,webLogoLargeApp:()=>qr,webLogoViewer:()=>lr});var i,r,o=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(r=i||(i={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var h=n(1858),u=n(5072),d=n.n(u),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),A=n.n(C),S=n(7939),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(S.A,x),S.A&&S.A.locals&&S.A.locals;var E=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};let M=null,_=null;function I(t,e){return t&&""!=t?t:e}n(2780);class T{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n    the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n  used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter(),null==M))return null;let t=null;return"info"in M&&(t=M.info),t?I(t.description,I(t.vendor,"No GPU description available")):"No GPU description available"}))}().then((t=>{t?(this.useWebGPU.tooltip+=` (${t})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class P{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class ${get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(t={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new T,[c.c.T_SNE]:new L},this.dbScanParams=new P,this.editorSettings=t,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((t=>{const e=t.options.get(l.n3)??"",n=t.friendlyName??t.name,i=t.options.get(l.C0)??"",r=t.options.get(l._X)??"",o=t.options.get(l.Gi)??"";this.editorSettings.semtype&&!e.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:t,semTypes:e?e.split(","):[],types:i?i.split(","):[],units:r?r.split(","):[],distanceFunctions:o?o.split(","):[]})})),this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let e=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:t=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[t])}}),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let h=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{h?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),h=!h}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const t=this.tableInput.value?.columns.toList().find((t=>!!this.columnFunctionsMap[t.name]))??null,e=s.input.column("Column",{table:this.tableInput.value,value:t,onValueChanged:()=>this.onColumnInputChanged(),filter:t=>!!this.columnFunctionsMap[t.name]});return this.colInputRoot||(this.colInputRoot=e.root),e}regenerateColInput(){let t=!1;this.colInputRoot&&(t=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),t&&Array.from(this.colInput.root.children).forEach((t=>this.colInputRoot.append(t))),this.onColumnInputChanged()}onTableInputChanged(){const t=this.tableInput.value;t&&(this.columnFunctionsMap={},t.columns.toList().forEach((t=>{Object.keys(this.supportedFunctions).forEach((e=>{const n=this.supportedFunctions[e].semTypes,i=this.supportedFunctions[e].types,r=this.supportedFunctions[e].units,o=!n.length||t.semType&&n.includes(t.semType),s=!i.length||i.includes(t.type),a=!r.length||t.meta.units&&r.includes(t.meta.units);o&&s&&a&&(this.columnFunctionsMap[t.name]||(this.columnFunctionsMap[t.name]=[]),this.columnFunctionsMap[t.name].push(e))}))})),this.regenerateColInput())}onColumnInputChanged(){const t=this.colInput.value;if(!t)return;const e=this.columnFunctionsMap[t.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:e[0],items:e,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const t=this.preprocessingFunctionInput.value,e=this.supportedFunctions[t].distanceFunctions;this.availableMetrics=[...e],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((t=>this.similarityMetricInputRoot.append(t))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[t].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],r="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:t=>{i.value=t}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:t=>{i.value=t}}):s.input.float(i.uiName,{value:i.value,onValueChanged:t=>{i.value=t}});t.append(r.root),i.disable?(r.enabled=!1,s.tooltip.bind(r.input??r.root,i.disableTooltip??"")):s.tooltip.bind(r.input??r.root,i.tooltip)})),t}async createPreprocessingFuncParamsDiv(t,e){if(s.empty(t),e.inputs.length<3)return s.div();const n=e.prepare(),i=await n.buildEditor(s.div());for(let r=2;r<e.inputs.length;r++){const o=e.inputs[r];(this.preprocessingFunctionSettings[o.name]||n.inputParams[e.inputs[r].name].value||o.defaultValue)&&(this.preprocessingFunctionSettings[o.name]=this.preprocessingFunctionSettings[o.name]??n.inputParams[o.name].value??o.defaultValue);const s=i.find((t=>t.property.name===o.name));s&&(null!==this.preprocessingFunctionSettings[o.name]&&void 0!==this.preprocessingFunctionSettings[o.name]&&(s.value=this.preprocessingFunctionSettings[o.name]),s.onChanged.subscribe((t=>{this.preprocessingFunctionSettings[o.name]=t})),t.append(s.root))}return t}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(t){try{const e=JSON.parse(t);await this.applyInput(e)}catch(t){o.shell.error("Error applying input from history"),console.error(t)}}async applyInput(t){try{const e=this.tableInput.value?.col(t.col);if(!e)throw new Error("Column not found");this.colInput.value=e,this.preprocessingFunctionInput.value=t.preprocessingFunction,this.similarityMetricInput.value=t.similarityMetric,this.plotEmbeddingsInput.value=t.plotEmbeddings,this.clusterEmbeddingsInput.value=t.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((e=>{null!=t.options[e]&&(this.methodsParams[t.methodName][e].value=t.options[e])})),this.methodInput.value=t.methodName,this.preprocessingFunctionSettings=t.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(t){o.shell.error("Error applying input from history"),console.error(t)}}}var R=n(9713),O=n(6295);const k=t=>null==t;function G(t,e,n,i){if(n>t[t.length-1])return;const r=t.findIndex((t=>n<t));t.pop(),t.splice(r,0,n),e.pop(),e.splice(r,0,i)}class F{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=e}async calc(t,e,n=!0,r){return await this.calcMulti([t],[e],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(t,e,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(t.length<1)throw new Error("values must contain at least one array");if(e.length!==t.length||r.length!==t.length||o.length!==t.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=t[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:t,fnNames:e,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((t,e)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?e(r):(u.set(o,i),s<m&&(m=s),a>f&&(f=a),t())}}))}await Promise.all(l),n&&u.forEach(((t,e)=>{u[e]=(t-m)/(f-m)})),i(u)}catch(t){a(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}class H{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(t,e=1e6){const n=200,i=new Uint32Array(n),r=t.distance.length,o=t.distance;for(let t=0;t<r;t++)i[Math.floor(o[t]*n)]++;let s=0,a=0;for(let t=0;t<n&&(s+=i[t],a=t,!(s>=e));t++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=t.i,d=t.j;let p=0;const m=(a+1)/n;for(let t=0;t<r;t++)o[t]<m&&(l[p]=u[t],c[p]=d[t],h[p]=o[t],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(t,e,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=t[0].length>2e4?await this.getMinimalThreshold(t,e,o,s,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),o.forEach(((t,e)=>o[e].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:t,startIdx:u,endIdx:p,threshold:r,fnNames:e,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:t,i:e,j:r,distance:o}})=>{t?(d[n].terminate(),h(t)):(d[n].terminate(),i({i:e,j:r,distance:o,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((t,e)=>t+e.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const t of p)f.set(t.i,b),g.set(t.j,b),y.set(t.distance,b),b+=t.i.length;return{i:f,j:g,distance:y}}async calc(t,e,n,i={}){return await this.calcMultiColumn([t],[e],n,[i],[1])}async getKNN(t,e,n=15,i={}){return await this.multiColumnKNN([t],[e],n,[i],[1])}async getThresholdKNN(t,e,n=.8,i={}){return await this.multiColumnThresholdKnn([t],[e],n,[i],[1])}async multiColumnThresholdKnn(t,e,r=.8,o,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==o.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:o,threshold:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:r}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:r}))}}));const d=await Promise.all(h),p=new Int32Array(t[0].length);for(const e of d)for(let n=0;n<t[0].length;++n)p[n]+=e.knnIndexes[n]?.length??0;const m={knnDistances:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e]))),knnIndexes:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e])))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)m.knnDistances[n][p[n]-1]=e.knnDistances[n][t],m.knnIndexes[n][p[n]-1]=e.knnIndexes[n][t],p[n]-=1;return m}async multiColumnSingleValueKNN(t,e,r,o=15,s,a,l=i.EUCLIDEAN){if(t.length!==r.length||t.length!==s.length||t.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=t[0].length,d=t.map((t=>t[e])),p=Math.ceil(u/this._workerCount);for(let e=0;e<this._workerCount;e++)h[e]=new Promise(((n,i)=>{const h=e*p,m=e===this._workerCount-1?u:(e+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[e].postMessage({values:t.map((t=>t.slice(h,m))),target:d,fnNames:r,opts:s,nNeighbours:o,weights:a,aggregationMethod:l,startIdx:h}),c[e].onmessage=({data:{error:t,knnDistances:r,knnIndexes:o}})=>{t?(c[e].terminate(),i(t)):(c[e].terminate(),n({knnDistances:r,knnIndexes:o}))}}));const m=await Promise.all(h),f={knnDistances:new Array(o).fill(99999),knnIndexes:new Array(o).fill(-1)};for(const t of m)for(let e=0;e<(t.knnDistances?.length??0);++e)G(f.knnDistances,f.knnIndexes,t.knnDistances[e],t.knnIndexes[e]);return f}async multiColumnKNN(t,e,r=15,o,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==o.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:r}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:r}))}}));const d=await Promise.all(h),p={knnDistances:new Array(t[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(t[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)G(p.knnDistances[n],p.knnIndexes[n],e.knnDistances[n][t],e.knnIndexes[n][t]);return p}async getSampleDistances(t,e,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=t[0].length*(t[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:t,startIdx:d,endIdx:p,sampleLength:h,fnNames:e,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:t,distance:e}})=>{a[l].terminate(),t?u(t):c({distance:e})}}));const d=await Promise.all(u),p=d.reduce(((t,e)=>t+e.distance.length),0),m=new Float32Array(p);let f=0;for(const t of d)m.set(t.distance,f),f+=t.distance.length;return m.sort(),m}catch(t){return a?.forEach((t=>t?.terminate())),console.error(t),new Float32Array(1).fill(.5)}}async getMinimalThreshold(t,e,n=[],r,o=i.EUCLIDEAN){try{const i=t.length*(t.length-1)/2,s=await this.getSampleDistances(t,e,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(t){return console.error(t),.5}}static calcSync(t,e,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const h=t.length*(t.length-1)/2;for(;a<h;){const e=k(t[l])||k(t[c])?1:n(t[l],t[c]);1-e>=i&&(r.push(l),o.push(c),s.push(e)),a++,c++,c===t.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,D,V=n(8774);(D=B||(B={})).none="none",D.bold="bold",D.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(t){t!==this._currentLineIdx&&(this._currentLineIdx=t,this.sp.render(this.ctx))}set linesToRender(t){this.updateLines(t),this.sp.render(this.ctx)}set linesVisibility(t){this.visibility=t,this.sp.render(this.ctx)}constructor(t,e,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=t,this.xAxisCol=this.sp.dataFrame.columns.byName(e),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=t=>{var e;(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(t.offsetX,t.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},this.canvas.onmousemove=t=>{var e;this.mouseOverLineId=(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)?-1:this.checkCoordsOnLine(t.offsetX,t.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},t.onEvent("d4-before-draw-scene").subscribe((t=>{this.renderLines()}))}updateLines(t){this.lines=t,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),t.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var t,e,n,i,r,o,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(t=this.lines.width)&&void 0!==t?t:1,this.ctx.strokeStyle=`rgba(${null!==(e=this.lines.color)&&void 0!==e?e:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let t=0;t<this.lines.from.length;t++)if(b.get(this.lines.from[t])&&b.get(this.lines.to[t])&&this.visibility.getBit(t)){let e=0;const n=this.sp.getMarkerSize(this.lines.from[t])/2,i=this.sp.getMarkerSize(this.lines.to[t])/2,b=this.sp.pointToScreen(this.lines.from[t]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[t]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const e=(null===(r=this.lines.colors)||void 0===r?void 0:r[t])?null===(o=this.lines.colors)||void 0===o?void 0:o[t]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[t])?null===(l=this.lines.opacities)||void 0===l?void 0:l[t]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${e},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[t])?null===(u=this.lines.widths)||void 0===u?void 0:u[t]:null!==(d=this.lines.width)&&void 0!==d?d:1}t===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[t];let A=null;if(b){e=this.getLineLength(w,C,S,x);const r=this.getPointOnDistance(w,C,S,x,i,e),o=this.getPointOnDistance(S,x,w,C,n,e);w=r.x,C=r.y,S=o.x,x=o.y,A=this.lines.from[t]>this.lines.to[t]?this.findControlPoint(b,w,C,S,x,t):this.findControlPoint(b,S,x,w,C,t),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(t))&&(e||(e=this.getLineLength(w,C,S,x)),e>this.arrowWidth)){const t=b?null:this.getPointOnDistance(w,C,S,x,i,e),n=b?A.x:w,r=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==t?void 0:t.x)&&void 0!==f?f:w,null!==(g=null==t?void 0:t.y)&&void 0!==g?g:C,n,r)}this.ctx.stroke(),this.ctx.closePath(),t===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(t){switch(this.currentLineStyle){case B.bold:t?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:t?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const t=new Path2D;t.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(t),this.ctx.closePath()}createMultiLinesIndices(){const t={};for(let e=0;e<this.lines.from.length;e++){let n=0,i=0;this.lines.from[e]<this.lines.to[e]?(n=this.lines.from[e],i=this.lines.to[e]):(n=this.lines.to[e],i=this.lines.from[e]),t[`${n}|${i}`]?(1===t[`${n}|${i}`].length&&(this.multipleLinesCounts[t[`${n}|${i}`][0]]=1,t[`${n}|${i}`].push(1)),this.multipleLinesCounts[e]=++t[`${n}|${i}`][1]):t[`${n}|${i}`]=[e]}}checkCoordsOnLine(t,e){let n=-1,i=null,r=null;const o=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(o.get(this.lines.from[s])&&o.get(this.lines.to[s])&&this.visibility.getBit(s)){const o=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,o,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);r=this.calculateDistToCurveLine(s,t,e,i,h,u)}else r=this.calculateDistToStraightLine(t,e,l,c);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=s)}return n}calculateDistToStraightLine(t,e,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return t>=r-2&&t<=o+2&&e>=s-2&&e<=a+2?this.distToStraightLineSegment(t,e,n,i):null}distToStraightLineSegment(t,e,n,i){const r=(t,e,n,i)=>Math.pow(t-n,2)+Math.pow(e-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(t,e,n.x,n.y);let s=((t-n.x)*(i.x-n.x)+(e-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(t,e,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(t,e,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(e>=s-2&&e<=a+2&&n>=l-2&&n<=c+2){const t=a-s,h=c-l;return this.calculateDistToCurveInRect(e,n,i,o,r,t,h)}return null}calculateDistToCurveInRect(t,e,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(t-a),f=Math.abs(e-p),g=m+f;(!d||d>g)&&(d=g),u[o]=Math.max(m,f),c[o]=a,h[o]=p}for(let t=0;t<c.length;t++)u[t]<d&&p.setBit(t,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-t,h[n]-e);(!m||m>i)&&(m=i)}return m}getLineLength(t,e,n,i){return Math.sqrt(Math.pow(n-t,2)+Math.pow(i-e,2))}getPointOnDistance(t,e,n,i,r,o){const s=n-r*((n-t)/o),l=i-r*((i-e)/o);return new a.Point(s,l)}findControlPoint(t,e,n,i,r,o){const s=e+(i-e)/2,l=n+(r-n)/2;let c=s-e,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(t/2);return t%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(t,e,n,i,r){const o=Math.atan2(i-e,r-n)+Math.PI;t.moveTo(e-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),t.lineTo(e,n),t.lineTo(e-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}var U,W,q=n(8060),z=n(3629);async function Y(t,e,i,r,s,a,l){let c=await async function(t,e,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==a.distanceFnArgs.length||t.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:t,distanceMetrics:e,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(q.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),t?h(t):c(e),setTimeout((()=>u.terminate()),100)):l&&l(n,i,e)}}))}(t,i,e,r,s,a,l);return c=c.map((t=>(0,z.S8)(t))),c}(W=U||(U={})).EUCLIDEAN="EUCLIDEAN",W.MANHATTAN="MANHATTAN";const K={[U.EUCLIDEAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[U.MANHATTAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.VECTOR_COSINE="Vector Cosine",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.EUCLIDEAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[Z.MANHATTAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[Z.VECTOR_COSINE]:function(t,e){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[Z.TANIMOTO]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[Z.LEVENSTEIN]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[Z.NEEDLEMAN_WUNSCH]:function(t,e){return`\n      let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${t+1}u>;\n      var horizontalGaps: array<u32, ${t+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${e};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${e};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${e}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${e}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.SOKAL]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[Z.COSINE]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[Z.ASYMMETRIC]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[Z.Difference]:function(t,e){return`\n    let range = suppInfo.range${e};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[Z.OneHot]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},Q={[Z.HAMMING]:t=>Math.ceil(t/30),[Z.EUCLIDEAN]:t=>Math.ceil(t/30),[Z.MANHATTAN]:t=>Math.ceil(t/30),[Z.TANIMOTO]:t=>Math.ceil(t/30),[Z.SOKAL]:t=>Math.ceil(t/30),[Z.COSINE]:t=>Math.ceil(t/30),[Z.ASYMMETRIC]:t=>Math.ceil(t/30),[Z.LEVENSTEIN]:t=>Math.ceil(t*t/60),[Z.NEEDLEMAN_WUNSCH]:t=>Math.ceil(t*t/60),[Z.MONOMER_CHEMICAL_DISTANCE]:t=>Math.ceil(t/25),[Z.Difference]:t=>1,[Z.OneHot]:t=>Math.ceil(t/40),[Z.VECTOR_COSINE]:t=>Math.ceil(t/30)},tt={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.VECTOR_COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference,Z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference,Z.VECTOR_COSINE]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var et=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function nt(t,e,n,i){return t.map(((t,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${J[t](e[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${t.length}>;\n        ${t.map(((t,e)=>`distances[${e}] = distanceScript${e}(aIndex, bIndex);`)).join("\n")}\n        ${K[i](t.length)}\n      }\n    \n    `}var it=n(1991),rt=n.n(it);let ot=0;const st="cliffsDf",at=new h.Subject,lt="Δ activity",ct="SALI",ht="Similarity",ut="line index",dt=["From","To"],pt="filterCliffs";async function mt(t,e,i,r,l,c,h,u,d,p,m,f,g,y,b,v,w){ot++;const C=c/100;let A,S=!1;const x=f.inputs,I=await f.apply({[x[0].name]:e,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let T=[];if(u===N){const e=await function(t,e,i,r,o,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:t,threshold:e,weights:i,aggregationMethod:r,distanceFns:o,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((t,e)=>{u=t,h.onmessage=e=>{setTimeout((()=>h.terminate()),100),t(e.data.res)},h.onerror=t=>{setTimeout((()=>h.terminate()),100),e(t)}})),terminate:()=>{try{u(null),h.terminate()}catch(t){console.error(t)}}}}([I.entries],c,[1],"MANHATTAN",[h],[I.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;t.columns.addNewInt(t.columns.getUnusedName("MCL Cluster")).init((t=>e.clusters[t])),T=[e.embedX,e.embedY]}else T=await Y([I.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[I.options??{}]});if(T.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let e=0;e<T.length;++e)t.columns.addNewFloat(i[e]).init((t=>T[e][t]));let L=null;if(d.useWebGPU)try{L=await function(t,e=.8,n,i,r,o){return et(this,void 0,void 0,(function*(){const s=yield function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==M))return null;let t=!1;if(_&&(_.lost.then((()=>{t=!0})),yield new Promise((t=>setTimeout(t,10)))),!_||t){const t=1e9,e=M.limits,n=e.maxBufferSize,i=e.maxStorageBufferBindingSize;try{return _=yield M.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,t),maxStorageBufferBindingSize:Math.min(i,t)}}),_}catch(t){return console.error("Failed to create device with required limits",t),_=yield M.requestDevice(),_}}return _}))}();if(!s)return null;const a=Object.values(Z);if(n.some((t=>!a.includes(t))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(U).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-e;if(o.length!==t.length||o.length!==n.length||o.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(t.some((e=>e.length!==t[0].length)))throw new Error("All entry lists must be the same length");const c=t.length,h=t[0].length,u=t.map(((t,e)=>function(t,e=Z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,o;let s=null;const a=t.some((t=>"string"==typeof t))?(s="STRING",t.map((t=>new Uint32Array(t.split("").map((t=>t.charCodeAt(0))))))):t.some((t=>"number"==typeof t))?(s="NUMBER",t.map((t=>new Float32Array([t])))):"object"==typeof t[0]&&t.some((t=>"_data"in t&&"_length"in t))?(s="BITARRAY",t.map((t=>t._data))):t.some((t=>t instanceof Float32Array))?(s="FLOAT32ARRAY",t):t.some((t=>t instanceof Uint32Array))?(s="UINT32ARRAY",t):t.some((t=>t instanceof Int32Array))?(s="INT32ARRAY",t):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((t=>t.length)));if(!tt[s]||!tt[s].has(e))throw new Error(`Distance metric '${e}' not supported for entry type '${s}'`);const h=c.reduce(((t,e)=>Math.max(t,e)),0),u=Q[e](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach(((t,e)=>{p.set(t,e*h)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(e===Z.NEEDLEMAN_WUNSCH||e===Z.MONOMER_CHEMICAL_DISTANCE){let t=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((t,e)=>Math.max(t,e.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let e=0;e<p.length;e++)p[e]>t&&(t=p[e]);i.scoringMatrix=new Array(t+1).fill(null).map((()=>new Array(t+1).fill(0))),i.alphabetIndexes={};for(let t=0;t<i.scoringMatrix.length;t++)i.scoringMatrix[t][t]=1,i.alphabetIndexes[String.fromCharCode(t)]=t}const e=(t+1)*(t+1),s=new Array(t+1).fill(null).map((()=>new Float32Array(t+1)));for(let e=0;e<t+1;e++)s[e][e]=1;const a=i.alphabetIndexes;for(const t of Object.keys(a))for(const e of Object.keys(a))t!==e&&(s[t.charCodeAt(0)][e.charCodeAt(0)]=i.scoringMatrix[a[t]][a[e]]);f=2+e,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=i.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(o=i.gapExtensionPenalty)&&void 0!==o?o:.6;let l=2;for(let t=0;t<s.length;t++)y.set(s[t],l),l+=s[t].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${t+1}>, ${t+1}>`}else if(e===Z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const t=p.reduce(((t,e)=>Math.min(t,e)),p[0]),e=p.reduce(((t,e)=>Math.max(t,e)),p[0]);i.range=e-t}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(t,n[e],e,o[e])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=u.map((t=>t.suppInfoStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((t=>t.dataStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((t,e)=>{f.set(t.arraySizes,e*h)}));const g=1e4,y=100,b=u.reduce(((t,e)=>t+e.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${S} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${nt(n,u.map((t=>t.maxEntryLen)),l,i)}\n\n\n    `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),$=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let t=0;t<g;t++){const e=9999===t?A-1:(t+1)*$,n=h-2-Math.floor(Math.sqrt(-8*e+4*h*(h-1)-7)/2-.5),i=e-h*n+Math.floor((n+1)*(n+2)/2);T[t]=O,L[t]=R,N[t]=i,P[t]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce(((t,e)=>t+e.sourceArraySize),0),G=u.reduce(((t,e)=>t+e.suppInfoSize),0),F=1e6,H=k*Uint32Array.BYTES_PER_ELEMENT;let B=H;const D=15&H;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,g).set(T),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(L),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(N),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(P),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f.length).set(f),W+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,W,c).set(r),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const t of u){const e=t.EncodedArrayConstructor,n=t.sourceArraySize;new e(j,W,n).set(t.flatSourceArray),W+=n*e.BYTES_PER_ELEMENT}V.unmap();const q=G*Uint32Array.BYTES_PER_ELEMENT;let z=q;const Y=15&q;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const t of u)t.suppInfoBuffer&&t.suppInfoBuffer.byteLength>0&&t.suppInfoSize>0&&(new("UINT32ARRAY"===t.suppInfoType?Uint32Array:Float32Array)(X,J,t.suppInfoBuffer.length).set(t.suppInfoBuffer),J+=t.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const et=302e4*Uint32Array.BYTES_PER_ELEMENT;let it=et;const rt=15&et;0!==rt&&(it+=16-rt);const ot=s.createBuffer({label:"results buffer",size:it,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),st=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:ot}}]}),at=s.createBuffer({label:"results out buffer",size:ot.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),lt=[],ct=[],ht=[];let ut=!1;for(;!ut;){const t=s.createCommandEncoder({label:"distance encoder"}),e=t.beginComputePass({label:"distance compute pass"});e.setPipeline(I),e.setBindGroup(0,st),e.dispatchWorkgroups(w,w),e.end(),t.copyBufferToBuffer(ot,0,at,0,at.size);const n=t.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield at.mapAsync(GPUMapMode.READ);const i=at.getMappedRange();let r=0;const o=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,ut=new Uint32Array(i,r,g).every((t=>1===t));const h=c.reduce(((t,e)=>t+e),0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let t=0;t<c.length;t++){const e=c[t];0!==e&&(u.set(o.subarray(t*y,t*y+e),m),d.set(a.subarray(t*y,t*y+e),m),p.set(l.subarray(t*y,t*y+e),m),m+=e)}lt.push(u),ct.push(d),ht.push(p),at.unmap()}const dt=lt.reduce(((t,e)=>t+e.length),0),pt=new Uint32Array(dt),mt=new Uint32Array(dt),ft=new Float32Array(dt);let gt=0;for(let t=0;t<lt.length;t++)pt.set(lt[t],gt),mt.set(ct[t],gt),ft.set(ht[t],gt),gt+=lt[t].length;return V.destroy(),K.destroy(),ot.destroy(),at.destroy(),{i:pt,j:mt,distance:ft}}))}([I.entries],C,[h],U.MANHATTAN,[1],[I.options??{}])}catch(t){console.error(t)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new H).calc(I.entries,h,C,I.options));const P=await async function(t,e){const n=t.distance.map(((n,i)=>{const r=Math.abs(e.get(t.i[i])-e.get(t.j[i]));return 0!=n?r/n:1/0})),i=t.distance.map((t=>1-t)),r=t.i,o=t.j,s=a.BitSet.create(e.length);return t.distance.forEach(((e,n)=>{s.set(t.i[n],!0),s.set(t.j[n],!0)})),{simVals:i,saliVals:n,n1:r,n2:o,cliffsBitSet:s}}(L,l),$=function(t,e,n,i,r,o,s){const l=new Array(t).fill(0);for(let t=0;t!=i.length;++t)n[t]!=1/0&&(s.get(i[t])>s.get(r[t])?l[i[t]]+=n[t]:l[r[t]]+=n[t]);return a.Column.fromList("double",e,l)}(e.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);t.columns.add($);const O=P.cliffsBitSet,k=function(t){const e=t.filter((t=>t!==1/0)),n=e.reduce(((t,e)=>Math.min(t,e)),Number.MAX_VALUE);return{max:e.reduce(((t,e)=>Math.max(t,e)),n),min:n}}(P.saliVals),G=.8/(k.max-k.min),F=o.shell.getTableView(t.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:$.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(t,e,n,i,r,o,s,l){const c={from:new Uint32Array(e.n1.length),to:new Uint32Array(e.n1.length),opacities:new Float32Array(e.n1.length),colors:new Array(e.n1.length),widths:new Float32Array(e.n1.length)};for(let n=0;n<e.n1.length;n++)c.from[n]=e.n1[n],c.to[n]=e.n2[n],c.opacities[n]=e.saliVals[n]===1/0?1:.2+(e.saliVals[n]-s.min)*l,c.colors[n]=t.selection.get(c.from[n])&&t.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return dt.forEach(((t,e)=>{h.columns.addNewString(t).init((t=>n.get(0===e?c.from[t]:c.to[t]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(h.col(t),o),h.col(t).semType=r})),h.columns.addNewFloat(lt).init((t=>Math.abs(i.get(c.from[t])-i.get(c.to[t])))),h.columns.addNewInt(ut).init((t=>t)),h.columns.addNewFloat(ct).init((t=>e.saliVals[t])),h.columns.addNewFloat(ht).init((t=>e.simVals[t])),h.name=`${st}${ot}`,{lines:c,linesDf:h}}(t,P,e,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ct).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const W=new j(D,i[0],i[1],V.lines,B.none),q=b?b(V.linesDf,dt).sort([ct],[!1]):V.linesDf.plot.grid().sort([ct],[!1]);q.col(ut)&&(q.col(ut).visible=!1),t.temp[".cliffsDfGrid"]=q;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{const t=rt()(F.viewers).some((t=>t.dataFrame.name===`${st}${ot}`));w&&!t&&F.addViewer(q),F.dockManager.dock(q,"down",null,"Activity cliffs",v??.2)}));z.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:e=>{e?(D.dataFrame.setTag(pt,i[0]),t.filter.and(O),at.next(i[0])):(D.dataFrame.setTag(pt,""),t.filter.setAll(!0),at.next(""))}});D.root.prepend(s.divH([z,K.root],"cliffs_div")),at.subscribe((t=>{K.enabled=""===t||t===i[0]}));let X=!1;D.onEvent("d4-before-draw-scene").subscribe((e=>{X?X=!1:K.value&&(setTimeout((()=>{t.filter.and(O)}),100),X=!0)}));const J=o.events.onViewerClosed.subscribe((t=>{t.args.viewer===D&&(F.dockManager.close(q.root),J.unsubscribe(),F.subs=F.subs.filter((t=>t!==J)))}));return F.subs.push(J),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let t=0;t<V.linesDf.rowCount;t++)V.lines.widths[t]=t===V.linesDf.currentRowIdx?3:1;W.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===dt[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;W.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(t,e,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=t/s,c=e/a,h=Math.min(l,c),u=t/h*5,d=e/h*5,p=(n<r?n:r)+s/2-u/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],V.lines.from[n]),D.dataFrame.get(i[1],V.lines.from[n]),D.dataFrame.get(i[0],V.lines.to[n]),D.dataFrame.get(i[1],V.lines.to[n]));D.zoom(a,h,c,u),K.value?t.filter.and(O):!0===K.enabled&&t.filter.setAll(!0),setTimeout((()=>{!function(t,e,n,i,r,a,l,c,h){const u=e.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:r,df:t,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{o.shell.o=e.root}),500)}(t,A,V.lines.from[r],V.lines.to[r],r,e,l,V.linesDf.get(ct,r),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(e.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((e=>{setTimeout((()=>(()=>{const e=a.BitSet.create(t.rowCount);for(let t=0;t<V.linesDf.rowCount;t++){const n=V.linesDf.selection.get(t);n&&(e.set(V.lines.from[t],!0),e.set(V.lines.to[t],!0)),V.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),W.linesToRender=V.lines})()),100)})),t.onSelectionChanged.subscribe((e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(S?S=!1:(t=>{t.selection.setAll(!1);for(let t=0;t<V.lines.colors.length;t++)V.lines.colors[t]="0,128,0";W.linesToRender=V.lines})(q.dataFrame))})),W.lineClicked.subscribe((e=>{if(S=!0,W.currentLineId=e.id,-1!==e.id){const n=V.linesDf.selection.clone();setTimeout((()=>{e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==e.id&&(V.linesDf.currentRowIdx=e.id,t.currentRowIdx=V.lines.from[e.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(q.sortByColumns,q.sortTypes);q.scrollToCell(dt[0],i.indexOf(e.id))}),500)}})),W.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===t.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:t,seqCol:e,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const t=s.accordion(),e=s.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(s.span([e,s.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),o.shell.o=t.root,t}(),D}var ft,gt=n(2003),yt=n(3516),bt=n(6718),vt=n(3077),wt=n(439);!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(ft||(ft={}));var Ct=n(9192);class At{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class St extends ${constructor(t={}){super({...t,enableMCL:!0});const e=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new At}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const t=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(t){super.applyInput(t),this.activitiesInput.value=this.tableInput.value.col(t.activityCol),this.similarityInput.value=t.simThreshold}}var xt,Et,Mt,_t=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function It(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function Tt(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map((t=>t.name)).join(", ")})`}n(5540),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(xt||(xt={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(Et||(Et={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(Mt||(Mt={})),Object.prototype.toString;var Lt=n(6873),Nt=n(4356),Pt=n(6717),$t=n(4870),Rt=n(3856),Ot=n(6882),kt=n(7278),Gt=n(5553),Ft=n(6642),Ht=n(3599),Bt=n(673),Dt=n(8312);class Vt extends Ft.sD{monomerLib=null;seqHelper=null;constructor(t,e){super(t,e,Di.logger),(0,bt.pj)().then((t=>{this.monomerLib=t.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Dt.Q)().then((t=>{this.seqHelper=t,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var jt=n(4139);const Ut=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class Wt extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(t){this.seqHandler.column.set(this.rowIdx,t)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===wt.YI.DNA}isRna(){return this.seqHandler.alphabet===wt.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===wt.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(t,e){if(null==e.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=e.column.dataFrame.cell(t,e.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=t,this.seqHandler=e}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const t=(0,kt.qp)(this.helm),e=[],n=/\(|\)/;for(let i=0;i<t.length;i++){const r=t.getOriginal(i),o=r.split(n).filter((t=>!!t));3===o.length?(e.push(o[0]),e.push(o[1]),e.push(o[2])):e.push(r)}return new kt.Mu(e,this.seqHandler.defaultGapOriginal)}}const qt=gt.zS;function zt(t){const e=!rt().enumerate(t).some((([e,n])=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";for(const[e,r]of rt().enumerate(t)){let o=e;r<t.length&&(o+=`${e?"":"-"}${i}`),n.push(o)}return[n,e]}class Yt extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=Di.seqHelper}getRendererBack(t){const[e,n,i]=(0,Ft.BG)(t);if(n.meta.units!==gt.Hi.CUSTOM)return i.rendererBack;let r=null;return this.seqHelper&&(r=this.seqHelper.getSeqHandler(n).getRendererBack(e,n)),r}onClick(t,e){if(t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate(),t.cell.column.meta.units===gt.Hi.CUSTOM){const n=this.getRendererBack(t);n?.onClick(t,e)}}onMouseEnter(t,e){const n=this.getRendererBack(t);n?.onMouseEnter(t,e),this.hasMouseOver=!0}onMouseMove(t,e){const n=this.getRendererBack(t);n?.onMouseMove(t,e)}onMouseLeave(t,e){if((0,Gt.WN)(t,null),t?.grid){const e=t.grid.onEvent("d4-grid-show-tooltip").subscribe((t=>{e.unsubscribe(),this.hasMouseOver&&t.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(t,e){const n=this.getRendererBack(t);n?.onDoubleClick(t,e)}onKeyDown(t,e){const n=this.getRendererBack(t);n?.onKeyDown(t,e)}onKeyPress(t,e){const n=this.getRendererBack(t);n?.onKeyPress(t,e)}renderInt(t,e,n,i,r,o,s){const[a,l,c]=(0,Ft.BG)(o);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(Di.properties?Di.properties.maxMonomerLength:4)??50;if(Rt.gp.maxMonomerLength in l.tags){const t=parseInt(l.getTag(Rt.gp.maxMonomerLength));d=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in h){const t=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(t)&&t?t:50}let p=c.rendererBack;p||(p=c.rendererBack=new Ot.Jy(a,l,Di.logger,d,(()=>{const{font:t,fontWidth:e}=Ot.Jy.getFontSettings(l);return{font:t,fontCharWidth:e,separatorWidth:u.isMsa()?8:0,monomerToShort:qt}})),l.temp[".mm.cellRenderer.settingsChanged"],Bt.s.true,p.init().then((()=>{}))),p.render(t,e,n,i,r,o,s)}render(t,e,n,i,r,o,s){if(o.cell.column?.meta?.units!==gt.Hi.CUSTOM)this.renderInt(t,e,n,i,r,o,s);else{const a=this.getRendererBack(o);a?.render(t,e,n,i,r,o,s)}}}class Kt extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell.value??"",h=this.tableCol.tags[gt.gp.separator],u=this.tableCol.meta.units;i=(0,Ot.U0)(l,t,e,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ut.notationProvider]?.separatorSplitter??(0,kt.Iv)(u,h),f=m(d),g=m(p),y=rt().count(0).take(f.length).map((t=>f.getCanonical(t))).toArray(),b=rt().count(0).take(g.length).map((t=>g.getCanonical(t))).toArray(),v=this.tableCol.getTag(gt.gp.alphabet);Xt(t,e,n,i,r,y,b,v===gt.YI.RNA||v===gt.YI.DNA?Ht.o.NUCLEOTIDE:Ht.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Ft.BG)(t);let r=i.rendererBack;return r||(r=i.rendererBack=new Kt(e,n)),r}}class Zt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return jt.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,r,o,s){Kt.getOrCreate(o).render(t,e,n,i,r,o,s)}}function Xt(t,e,n,i,r,o,s,a,l,c,h){if(o.length!==s.length){const t=function(t,e){let n=0,i=0;const r=t.length>e.length?t:e,o=t.length>e.length?e:t;for(let t=0;t<o.length;t++)r[t]===o[t]&&n++;const s=r.length-o.length;for(let t=r.length-1;t>s;t--)r[t]===o[t-s]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill(wt.b9[gt.Hi.FASTA]);function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(rt()(e).toArray()):t=l(rt()(t).toArray()),{subParts1:t,subParts2:e}}(o,s);o=t.subParts1,s=t.subParts2}const u=t.measureText(zt(o).join("")),d=t.measureText(zt(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*o.length,t.canvas.width=p+4*o.length);let m=Math.max(e,e+(i-(p+4*o.length))/2)+5;const f=Math.max(n,n+(r-28)/2);t.save();try{t.beginPath(),t.rect(e,n,c?p+4*o.length:i,r),t.clip(),t.font="12px monospace",t.textBaseline="top";const u=7;for(let e=0;e<o.length;e++){const n=o[e],c=s[e];let d=Ot.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let o=Ot.S$;l&&(o=l.getMonomerTextColor(a,c));const s=(0,Rt.oZ)(t,n,m,f-u,i,r,{color:d,pivot:0,left:!0}),p=(0,Rt.oZ)(t,c,m,f+u,i,r,{color:o,pivot:0,left:!0});m=Math.max(p,s),h&&(h[e]=Jt(n,c,d,o,f,u,r))}else m=(0,Rt.oZ)(t,n,m,f,i,r,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{t.restore()}}function Jt(t,e,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(zt([t]).join("")).width,h=l.measureText(zt([e]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Rt.oZ)(l,t,0,r-o,u,s,{color:n,pivot:0,left:!0}),(0,Rt.oZ)(l,e,0,r+o,u,s,{color:i,pivot:0,left:!0}),a}var Qt,te=n(8070),ee=n(4326);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(Qt||(Qt={}));const ne=new class{constructor(){this.regionTypes=[Qt.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ee.fH.Entropy,this.filterSource=ee.Fo.filterSource}};var ie=n(7602),re=n(250);const oe=Qt;var se,ae;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(se||(se={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(ae||(ae={}));const le=ne;class ce extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ae.skipEmptyPositions,le.skipEmptyPositions,{category:se.DATA}),this.regionTypes=this.stringList(ae.regionTypes,le.regionTypes,{category:se.DATA,choices:Object.values(oe).filter((t=>t!=oe.Unknown))}),this.chains=this.stringList(ae.chains,le.chains,{category:se.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ae.fitWidth,le.fitWidth,{category:se.LAYOUT}),this.positionWidth=this.float(ae.positionWidth,le.positionWidth,{category:se.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ae.positionHeight,le.positionHeight,{category:se.LAYOUT,choices:Object.keys(ee.fH)}),this.filterSource=this.string(ae.filterSource,le.filterSource,{category:se.BEHAVIOR,choices:Object.values(ee.lT)}),this.viewSyncer=new ie.g(Di.logger)}static viewerCounter=-1;viewerId=++ce.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=`${this.viewerToLog()}.detach()`,e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),e())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case ae.regionTypes:case ae.chains:this.setData(this.regions)}switch(t.name){case ae.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ae.fitWidth:case ae.positionWidth:this.calcSize();break;case ae.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ae.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){const e=`${this.viewerToLog()}.setData()`;Di.logger.debug(`${e}, in, regions.length = ${t.length}`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(t){Di.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Di.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<n.length;t++)for(const r of this.chains){const o=e.find((e=>e.order==n[t]&&e.chain==r));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,r,e]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let t=0;t<n.length;++t)this.logos[t]={};for(const[t,e,n]of r)this.logos[t][e]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(ee.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Di.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Di.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let n=0;n<this.logos.length;n++){for(const e of this.chains)this.logos[n][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[n][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,n=13,i=9,r=(this.root.clientWidth-t-(this.logos.length-1)*i-n)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const n=this.logos[t][e];n.setOptions({[re.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,e=this.filterSourceInput.value;this.viewSyncer.sync(`${t}`,(async()=>{if(this.filterSource!==e){this.props.getProperty(ae.filterSource).set(this,e);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const n=this.chains[e];this.logos[t][n].setOptions({[re.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.viewerToLog()}.invalidate(${t?` <- ${t} `:""})`;this.viewSyncer.sync(`${e}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,te.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}var he=n(6625),ue=n(6863);async function de(t,e,n="Morgan"){const i=t.length,r=Di.seqHelper.getSeqHandler(t),o=Array(i);let s=1;const a=new Map,l=t.categories,c=t.getRawData();for(let e=0;e<i;e++){if(null===l[c[e]]||t.isNone(e)){o[e]=null;continue}o[e]="";const n=r.getSplitted(e);for(let t=0;t<n.length;t++){const i=n.getCanonical(t);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[e]+=a.get(i)}}let h={};if(e===ue.Z.MONOMER_CHEMICAL_DISTANCE||e===ue.Z.NEEDLEMANN_WUNSCH){const t=Array.from(a.keys()),e=await(0,bt.A7)(t,n),i={};Object.entries(e.alphabetIndexes).forEach((([t,e])=>{i[a.get(t)]=e}));const r=o.reduce(((t,e)=>Math.max(t,e.length)),0);h={scoringMatrix:e.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:h}}var pe=n(8115);function me(t){const e=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.points.forEach((n=>{const i=s.divText(t.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),i]))})),e}function fe(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);t.points.forEach(((e,i)=>{n[i]=t.activityCol.get(e)}));const i={},r=Di.seqHelper.getSeqHandler(t.seqCol),o=r.defaultBiotype,a=ye(r.getSplitted(t.points[0]),r.getSplitted(t.points[1]),o,i);return e.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),e.append(be(i)),e.append(ge("Activity delta",Math.abs(n[0]-n[1]))),e.append(ge("Cliff",t.sali)),e}function ge(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function ye(t,e,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");r.height=30;const s=Di.monomerLib;return Xt(o,0,0,0,30,rt().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),rt().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),n,s,!0,i),r}function be(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function ve(t,e){const n=a.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=t.col(e[0]).meta.units,n.setTag(gt.gp.separator,t.col(e[0]).getTag(gt.gp.separator)),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}class we extends a.JsViewer{constructor(t,e){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...e?{semType:e}:{}}),this.name=t,this.semType=e}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>{this.gridSelect||this.render(t)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("targetColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===this.semType&&(this.targetColumn=e)}this.debouncedRender()}}debouncedRender(t=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(t),this.debounceTimer=null}),100)}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ce extends we{distanceMetric;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];tags=[a.TAGS.UNITS,gt.gp.aligned,gt.gp.separator,gt.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;constructor(t,e){super(t,e),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS})}async onTableAttached(){super.onTableAttached(),this.dataFrame&&(this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3)}}const Ae={gapPenalty:1,matchScore:1,gapSymbol:wt.b9[wt.Hi.FASTA],localAlignment:!1};class Se extends Ce{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;constructor(t,e){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.targetColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(t,this.idxs.length).init((t=>this.targetColumn?.get(this.idxs?.get(t)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.targetColumn.getTag(t))));const e=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;e.onCurrentRowChanged.subscribe((t=>{n&&clearTimeout(n),(e.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=e.col("indexes").get(e.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(e)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=e,this.analysisGrid.invalidate()):(this.analysisGrid=e.plot.grid(),(0,$t.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,$t.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}async computeByMM(){const t=this.targetColumn.length,e=Math.min(this.limit,t-1);if(!this.knn||this.kPrevNeighbors!==e){const n=(await de(this.targetColumn,ue.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=e,this.knn=await(new H).getKNN(n,ue.Z.LEVENSHTEIN,Math.min(this.limit,t-1))}const n=new Array(e).fill(0).map(((t,e)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][e],score:1-this.knn.knnDistances[this.targetMoleculeIdx][e]})));n.sort(((t,e)=>e.score-t.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",e+1).init((t=>n[t].idx)),this.scores=a.Column.float("score",e+1).init((t=>n[t].score))}createPropertyPanel(t){const e=s.div(),n={},i=this.molCol?.name,r=t.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(r),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(t.currentRowIdx),u=function(t,e,n={}){const i={...Ae,...n},r=t.length,o=e.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(t.getCanonical(n-1)===e.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,h=i.localAlignment?l[1]:o,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(t.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1)}u=[...rt().count(0).take(c).map((e=>t.getCanonical(e))),...u.reverse(),...i.localAlignment?rt().count(l[0]).take(r).map((e=>t.getCanonical(e))):[]],d=[...rt().count(0).take(h).map((t=>e.getCanonical(t))),...d.reverse(),...i.localAlignment?rt().count(l[1]).take(o).map((t=>e.getCanonical(t))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new kt.Mu(u,i.gapSymbol),seq2Splitted:new kt.Mu(d,i.gapSymbol)}}(c,h),d=ye(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(be(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>e),!0),o.shell.o=p.root}}var xe=n(1407);class Ee extends Ce{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;constructor(t){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.targetColumn){const t=this.seqHelper.getSeqHandler(this.targetColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,n=a.Column.string(e,this.renderMolIds.length).init((t=>this.targetColumn?.get(this.renderMolIds[t])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>n.setTag(t,this.targetColumn.getTag(t))));const i=a.DataFrame.fromColumns([n]);n.temp[".mm.cellRenderer.maxMonomerLength"]=4,i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]}));const r=i.plot.grid();(0,$t.Kd)(r,n.name,450,30),(0,$t.Ku)(this.root,r.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xe.R)(this.targetColumn,this.seqHelper);a.DataFrame.fromColumns([t]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=(await de(this.targetColumn,ue.Z.LEVENSHTEIN)).seqList,e=new F(!0,!1),n=await e.calc(t,ue.Z.LEVENSHTEIN);e.terminate();const i=this.targetColumn.length,r=(o=i,(t,e)=>o*t+e-Math.floor((t+2)*(t+1)/2));var o;this.renderMolIds=function(t,e,n){function i(t,e){let n=null,i=null;for(const r of t){const t=e(r);(null==i||t>i)&&(n=r,i=t)}return n}const r=[(s=t-1,Math.floor(function(t){return Math.random()*t}(s)))],o=new Set;var s;for(let e=0;e<t;++e)r.includes(e)||o.add(e);for(;r.length<e;){const t=i(o.values(),(t=>Math.min.apply(Math,r.map((function(e,i){return n(t,e)})))));null!=t&&(r.push(t),o.delete(t))}return r}(i,Math.min(i,this.limit),((t,e)=>this.targetColumn.isNone(t)||this.targetColumn.isNone(e)?0:n[r(t,e)]))}}var Me,_e=n(5433),Ie=n(3890),Te=n(1687);!function(t){t.TYPE="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t[t.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",t.RGP_LINE_START="M  RGP",t.ATOM_ALIAS_LINE_START="A  ",t.END="M  END"}(Me||(Me={}));class Le{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let n=t;const i=this.isWhitespace(n)?e:e-1;for(let t=0;t<i;t++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let n=this.getAtomBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToAtomType(n),e[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[t,e,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:n}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[n]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let n=this.getBondBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToBondType(n),e[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let n=e+1;for(;!this.isWhitespace(n);)++n;return t(this.fileContent.substring(e,n))}}class Ne extends Le{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,n=e;return this.isQuote(e)?(n=this.getNextIdenticalChar(e),e++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(e,n)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((n=this.fileContent.charCodeAt(e+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(n=this.shiftIdxToAtomType(n),t(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pe extends Ne{constructor(t){super(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map,e=this.fileContent.split("\n");e.filter((t=>t.startsWith(Me.RGP_LINE_START))).forEach((e=>{const n=this.getAtomIdxToRgpIdxList(e);for(const[e,i]of n){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,i)}}));const n=e.map(((t,e)=>{if(t.startsWith(Me.ATOM_ALIAS_LINE_START))return e})).filter((t=>void 0!==t)),i=n.map((t=>e[t])),r=n.map((t=>e[t+1]));i.forEach(((e,n)=>{const i=parseInt(e.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(t.has(o))throw new Error(`R group ${o} is already in the map`);t.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return t}getAtomIdxToRgpIdxList(t){const e=t.split(/\s+/).filter((t=>t)).slice(3).map((t=>parseInt(t))),n=new Array(e.length/2);for(let t=0;t<e.length;t+=2)n[t/2]=[e[t+1],e[t]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((t,e)=>{if(t.includes("R#"))return e})).filter((t=>void 0!==t))}static isValidMolfile(t){return-1!==t.indexOf(Me.TYPE)&&-1!==t.indexOf(Me.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,Me.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<Me.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,Me.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,Me.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+Me.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(t,e));return t=e,e+=Me.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class $e extends Ne{constructor(t){super(t),this.init(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map;return this.getAtomLines().forEach(((e,n)=>{const i=e.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const e=i[1].split(/\s+/).map((t=>parseInt(t)));if(e.length>2)throw new Error(`R group data ${e} has more than 2 elements`);const r=e[1];if(t.has(r))throw new Error(`R group ${r} is already in the map`);t.set(r,n)}})),t}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M  V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M  END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M  V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const n=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class Re{constructor(){}static getInstance(t){if(Re.isMolfileV2K(t))return new Pe(t);if(Re.isMolfileV3K(t))return new $e(t);throw new Error("Malformed molfile")}static isMolfileV2K(t){return Pe.isValidMolfile(t)}static isMolfileV3K(t){return $e.isValidMolfile(t)}}var Oe=n(6197),ke=n(9124),Ge=n(3527);class Fe{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(t,e,n="missing",i=void 0,r=void 0,o=void 0,s){if(this.biotype=t,this.id=e,this.n=n,this.m=i,this.type=r,this.mt=o,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Fe.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class He extends Fe{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(t){super(t,"*","gap")}}class Be extends Fe{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(t,e){super(t,e,"ambiguous")}}class De extends Fe{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(t,e,n){super(t,e,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Ve extends Fe{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(t,e){super(t,e,"broken")}}class je{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(t,e,n,i,r,o,s,a){this.id=t,this.m=e,this.n=n,this.na=i,this.type=r,this.mt=o,this.at=s,this.smiles=a}static fromMonomer(t,e,n){let i={};const r=e.symbol,o=e.smiles;if(e.rgroups.length>0)e.rgroups.forEach((t=>{i[t.label]=t.capGroupName}));else{if(!o){if(e.lib)return new Ve(t,r);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(o)}const s=new je(e.symbol,e.molfile,e.name,e.naturalAnalog,e.polymerType,e.monomerType,i),a=n.getMonomerColors(t,e.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Ue={[Ht.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ht.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ht.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ht.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ht.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ht.o.CHEM]:{R:"#eeeeee"},[Ht.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},We=/[\w()]+/,qe=RegExp(String.raw`\(${We}(,${We})+\)`),ze=t=>{const e=s.canvas(250,250);return o.chem.canvasMol(0,0,250,250,e,t),e},Ye=new Ge.Mi([255,255,255]),Ke=new Ge.Mi([0,0,0]),Ze=.7*(0,z.wQ)(Ye);class Xe{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(t,e){this._monomers=t,this.source=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([t,e])=>0===Object.keys(e).length));for(const[t,e]of Object.entries(this._monomers))for(const[t,n]of Object.entries(e))n.lib=this}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}addMissingMonomer(t,e){let n=this._monomers[t];n||(n=this._monomers[t]={});let i=e;return e==wt._S||e===wt.b9[wt.Hi.HELM]?i="Gap":("PEPTIDE"===t&&"X"===e||"RNA"===t&&"N"===e)&&(i="Any"),n[e]={symbol:e,name:i,molfile:"",author:"MISSING",id:-1,rgroups:rt().count(1).take(9).map((t=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${t.toString()}`}))).toArray(),smiles:"",polymerType:t,monomerType:void 0,createDate:null}}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?e[n]:null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}getWebEditorMonomer(t,e){const[n,i]=(0,ke.fA)(t,e),r=(0,Oe.Y)(n);let o=this.getMonomer(r,i);if(o&&n==Ht.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==Ht.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(r,i));let s=o.wem??null;return s||(i===wt._S||"*"==i?s=o.wem=new He(n):n===Ht.o.NUCLEOTIDE&&"N"===i||n===Ht.o.AA&&"X"===i||(Ht.o.CHEM,0)||qe.test(i)?s=o.wem=new Be(n,i):o.lib||(s=o.wem=new De(n,i,this.isEmpty)),s||(s=o.wem=je.fromMonomer(n,o,this))),s}getTooltip(t,e){const n=(0,Oe.Y)(t),i=s.div([],{classes:"ui-form ui-tooltip"}),r=this.getWebEditorMonomer(t,e),o=this.getMonomer(n,e);if(o){const t=o.symbol,[e,n,a]=(o.name,r?[r.textcolor,r.backgroundcolor,r.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([t],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:e,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([o.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=o.molfile?ze(o.molfile):o.smiles?s.divV([ze(o.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),o.symbol!=wt._S){let t=o.lib?.source;t?(t.endsWith(".json")&&(t=t.substring(0,t.length-5)),t=t.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(t))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${e}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(t,e){const n=this.getMonomerColors(t,e),i=t=>{const e=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(t);if(e)return[parseInt(e[1]),parseInt(e[2]),parseInt(e[3])];const n=a.Color.fromHtml(t);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},r=i(n.textcolor),o=new Ge.Mi([...r.map((t=>t+1))]),s=(0,z.KE)(o,Ye)/((0,z.wQ)(o)*(0,z.wQ)(Ye)),l=i(n.backgroundcolor),c=new Ge.Mi([...l.map((t=>t+.01))]);let h;h=(0,z.KE)(c,Ye)/((0,z.wQ)(c)*(0,z.wQ)(Ye))<s?l:r;let u=new Ge.Mi(h);const d=(0,z.wQ)(u);return d>Ze&&(u=(0,z.dC)(Ke,u,Ze/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(t,e){const n="default";let i=n;const r=(0,Oe.Y)(t),o=this.getMonomer(r,e);let s;if(o){if(o.meta&&o.meta.colors){const t=o.meta.colors;n in t||(i="default"),s=t[i]}if(!s){const e=Ue[t],n=e?.[o.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const e=o.naturalAnalog;if(!s&&e)return this.getMonomerColors(t,e)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(t){const e=t.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,r="";if(e)for(let t=0;t<e.length;t++)if(null!=e[t]&&/\d/.test(e[t])){i=e[t][e[t].length-1],e[t]=e[t].replace(/[0-9]/g,"");for(let n=0;n<e[t].length;n++)":"!=e[t][n]&&(r+=e[t][n]);n["R"+i]=r,r=""}return n}}var Je=n(5488),Qe={};Qe.styleTagTransform=A(),Qe.setAttributes=b(),Qe.insert=g().bind(null,"head"),Qe.domAPI=m(),Qe.insertStyleElement=w(),d()(Je.A,Qe),Je.A&&Je.A.locals&&Je.A.locals;class tn extends Xe{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(t,e,n=void 0){super(t,e),this.error=n}toJSON(){const t=[];for(const e of Object.values(this._monomers))for(const n of Object.values(e))t.push({...n,lib:void 0,wem:void 0});return t}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?.[n]??null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}_monomerSets=null;getMonomerSet(t){const e=(0,Oe.Y)(t);if(this._monomerSets||(this._monomerSets={}),!(t in this._monomerSets))for(const[t,n]of Object.entries(this._monomers[e]));return this._monomerSets[t]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((n=>{e[n]=this._monomers[t][n].molfile})),e}getMonomerSymbolsByRGroup(t,e,n){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let n=e?.rgroups.length>=t;var i;return i=Re.getInstance(e.molfile).atomTypes,i.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),n&&=!0,n})),i.map((t=>t?.symbol)))}_updateLibInt(t){const e=t.getPolymerTypes(),n=this.getPolymerTypes();e.forEach((e=>{n.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((n=>{this._monomers[e][n]&&(this._duplicateMonomers[e]??={},this._duplicateMonomers[e][n]??=[this._monomers[e][n]],this._duplicateMonomers[e][n].push(t.getMonomer(e,n))),this._monomers[e][n]=t.getMonomer(e,n)}))})),this._isEmpty=this.isEmpty&&t.isEmpty}updateLibs(t,e=!1){e&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const e of t)e.error||this._updateLibInt(e);Object.entries(this.duplicateMonomers).length>0?(0,Nt.ub)().then((t=>{this.assignDuplicatePreferences(t)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(t){let e=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(t.duplicateMonomerPreferences?.[n]?.[i]){const r=t.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((t=>t.lib?.source===r));o?this._monomers[n][i]=o:e=!1}else e=!1;return this._duplicatesHandled=e,e}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const t={},e=this.getPolymerTypes();for(const n of e)t[n]=this.getMonomerSymbolsByType(n).length;return t}getSummaryDf(){const t=this.getPolymerTypes(),e=new Array(t.length);for(const[n,i]of rt().enumerate(t))e[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",t),a.Column.fromList(a.COLUMN_TYPE.INT,"count",e)])}getSummary(){const t=this.getPolymerTypes();return 0==t.length?"empty":t.map((t=>`${t} ${this.getMonomerSymbolsByType(t).length}`)).join("\n")}static overrideCounter=0;override(t,e){return new en(t,`override: ${++tn.overrideCounter}, ${e}`,this)}}class en extends Xe{data;base;constructor(t,e,n){super(t,e),this.data=t,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(t){const e=this.base.getMonomerSymbolsByType(t);for(const n of Object.keys(this.data[t]??{}))e.includes(n)||e.push(n);return e}addMissingMonomer(t,e){return this.base.addMissingMonomer(t,e)}getMonomer(t,e){const n=this.data[t]?.[e];return n??this.base.getMonomer(t,e)}}class nn{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(t,e,n,i,r){this.monomerLib=t,this.symbol=e,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((t=>{const n=this.monomerLib.getMonomer(this.polymerType,t.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=t.source)throw new Error(`Monomer '${e}' found in different library.`);return n}))}catch(t){const[e,n]=(0,Ct.AP)(t);this.error=e,this.monomers=[]}}}class rn{description;placeholders;source;error;constructor(t,e,n=void 0,i=void 0){this.description=t,this.placeholders=e,this.source=n,this.error=i}updateSets(t,e=!1){e&&(this.placeholders=[]);for(const e of t)e.error||this._updateSetInt(e)}_updateSetInt(t){for(const e of t.placeholders)this.placeholders.push(e)}}var on=n(7433),sn=n.n(on),an=n(1913),ln=n.n(an);class cn{helmMonomerSchema;validateMonomerSchema;constructor(t){this.helmMonomerSchema=t;const e=new(sn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});ln()(e),this.validateMonomerSchema=e.compile(this.helmMonomerSchema)}validateFile(t,e){const n=this.parseJson(t,e);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,e):(console.warn(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(t,e){try{return JSON.parse(t)}catch(t){return console.error(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format:`,t),null}}validateJsonContent(t,e){let n=!0;const i=new Set;for(const r of t){const t=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' violating JSON schema:`,r,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${e} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${t}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}var hn=n(8604);class un{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(t,e,n,i){let r;this.fileValidator=t,this.libHelper=e,this.eventManager=n,this.logger=i;let o=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((t=>r=t))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),o||(o=!0,r())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++un.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(t,e,n){const i=await o.dapi.files.readAsText(hn.gt),r=JSON.parse(i),s=new cn(r);return new un(s,t,e,n)}async addLibraryFile(t,e,n=!0){try{if(await o.dapi.files.exists(hn.so+`${e}`))return void o.shell.error(`File ${e} already exists`);await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(hn.so+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(hn.so+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){console.error(t),o.shell.error(`Failed to add ${e} library`)}}async deleteLibraryFile(t){try{await o.dapi.files.delete(hn.so+`${t}`),await this.updateValidLibList(),o.shell.info(`Deleted ${t} library`)}catch(e){console.error(e),await o.dapi.files.exists(hn.so+`${t}`)?o.shell.error(`Failed to delete ${t} library`):o.shell.warning(`File ${t} already deleted, refresh the list`)}}async loadLibraryFromFile(t,e){let n=[];const i=new a.FileSource(t),r=await i.readAsText(e);n=JSON.parse(r);const o={},s=[];return n.forEach((t=>{const e=t.polymerType,n=t.symbol;s.includes(e)||(o[e]={},s.push(e)),o[e][n]=t})),new tn(o,e)}async loadSetFromFile(t,e,n){let i={};const r=new a.FileSource(e),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([e,n])=>{const i=e,r=n.polymerType,o=n.monomerType,s=n.set;return new nn(t,i,r,o,s)}));return new rn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const t=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${t}, end, not changed`);for(const t of n){if(!t.endsWith(".json")){e.push(t);continue}const n=await o.dapi.files.readAsText(hn.so+`${t}`);this.isValidHELMLibrary(n,t)||e.push(t)}const i=n.filter((t=>!e.includes(t)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((t=>!t.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),e.length>0){const t=`Invalid monomer library files in ${hn.so}, consider fixing or removing them: ${e.join(", ")}`;this.logger.warning(t)}this.logger.debug(`${t}, OUT`)})),this.logger.debug(`${t}, end`),this.filesPromise}async updateValidSetList(){const t=`${this.toLog()}.updateValidSetList()`;return Di.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{Di.logger.debug(`${t}, IN`);const e=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Di.logger.debug(`${t}, end, not changed`);for(const t of n)t.endsWith(".json")?await o.dapi.files.readAsText(hn.Es+`${t}`):e.push(t);const i=n.filter((t=>!e.includes(t)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Di.logger.debug(`${t}, OUT`)})),Di.logger.debug(`${t}, end`),this.filesPromise}libListHasChanged(t){const e=this.eventManager.getValidLibPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}setListHasChanged(t){const e=this.eventManager.getValidSetPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}async validateAgainstHELM(t,e){if(!this.isValidHELMLibrary(t,e))throw new Error(`File ${e} does not satisfy HELM standard`)}isValidHELMLibrary(t,e){return this.fileValidator.validateFile(t,e)}async getLibFileListAtLocation(){const t=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await o.dapi.files.list(hn.so).then((t=>t.filter((t=>t.isFile)).map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(hn.so.length)))}async getSetFileListAtLocation(){const t=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await o.dapi.files.list(hn.Es).then((t=>t.map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(hn.Es.length)))}}class dn{constructor(){}static _instance;static getInstance(){return dn._instance||(dn._instance=new dn),dn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((t=>{const e=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{t(n),e.unsubscribe()}))}))}changeValidLibPathList(t){this._libFilesUpdateSubject$.next(t)}changeValidSetPathList(t){this._setFilesUpdateSubject$.next(t)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(t,e){this._librarySelectionSubject$.next([t,e])}}class pn{logger;_monomerLib=new tn({},"MAIN");_monomerSets=new rn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(t=1/0){return t=t===1/0?6e4:t,await Promise.race([(async()=>{const t=await this.getFileManager();return await t.filesPromise,!0})(),(async()=>(await(0,te.cb)(t),!1))()]).then((e=>{if(!e)throw new Error(`Loading monomer libraries timeout ${t} ms.`)}))}constructor(t){this.logger=t}static objCounter=-1;objId=(()=>{if(++pn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return pn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(t){this._monomerLib.assignDuplicatePreferences(t)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const t=await un.create(this,this._eventManager,this.logger);return await t.initializedPromise,t})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(t=!1){const e=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${e}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[e],i]=await Promise.all([await this.getFileManager().then((t=>[t.getValidLibraryPaths()])),(0,Nt.ub)()]),r=e.filter((t=>{const e=!i.exclude.includes(t),n=0===i.explicit.length||i.explicit.includes(t);return e&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((t=>this.readLibrary(hn.so,t).catch((e=>{const n=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn({},t,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,t),this._initialLoadCompleted=!0}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;o.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{n.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadLibrariesPromise}async loadLibraries(t){return this.loadMonomerLib(t)}loadSetsPromise=Promise.resolve();async loadMonomerSets(t=!1){const e=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${e}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[e]]=await Promise.all([await this.getFileManager().then((t=>[t.getValidSetPaths()]))]),n=e.filter((t=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((e=>this.readSet(hn.Es,e).catch((t=>{const n=`Loading monomer sets from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new rn("Broken monomer set",[],e,n)})).finally((()=>{t.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(t){const e=`Loading monomer sets error: ${t instanceof Error?t.message:t.toString()}`;o.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{t.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadSetsPromise}async readLibrary(t,e){const n=await this.getFileManager();return await n.loadLibraryFromFile(t,e)}async readSet(t,e){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,t,e)}async selectSpecifiedLibraries(t){const e=await this.getInvalidFileNames(t);if(e.length>0)throw new Error(`Cannot select libraries ${e}: no such library in the list`);const n=await(0,Nt.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((e=>!t.includes(e))),await(0,Nt.Eu)(n)}async getInvalidFileNames(t){const e=(await this.getFileManager()).getValidLibraryPaths();return t.filter((t=>!e.includes(t)))}async loadMonomerLibForTests(){await(0,Nt.Eu)(hn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let t=window.$monomerLibHelperPromise;return null==t&&(t=window.$monomerLibHelperPromise=(async()=>{const t=new pn(Di.logger);return t._eventManager=dn.getInstance(),t})()),t}}var mn=n(1757),fn=n.n(mn),gn=n(3017),yn={};yn.styleTagTransform=A(),yn.setAttributes=b(),yn.insert=g().bind(null,"head"),yn.domAPI=m(),yn.insertStyleElement=w(),d()(gn.A,yn),gn.A&&gn.A.locals&&gn.A.locals;var bn=n(3151);class vn{constructor(t,e=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=t,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=e,this.render()}get root(){return this._root}get items(){return this._items}set items(t){this._items=t,this.render()}addItem(t,e=!0){this._items.push(t),this.render(),e&&this.onItemAdded.next(t)}removeItem(t,e=!0){-1!==this._items.indexOf(t)&&(this._items.splice(this._items.indexOf(t),1),this.render(),e&&this.onItemRemoved.next(t))}removeAtIndex(t,e=!0){if(t<0||t>=this._items.length)return;const n=this._items.splice(t,1);this.render(),e&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var t,e,n,i,r;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(t=n.caption)&&void 0!==t?t:n.name;(null===(e=this.options.customLabels)||void 0===e?void 0:e[n.name])&&(i=this.options.customLabels[n.name]);const r=s.divText(i);r.style.fontWeight="bold",this._root.appendChild(r)}for(const t of this._items){const e=this.getItemDiv(t);for(const t of e)this._root.appendChild(t)}if(this.options.allowAdd){const t=this.getItemDiv(null!==(r=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==r?r:void 0,!0);for(const e of t)this._root.appendChild(e)}}get addingItem(){const t={};return Object.keys(this.addingItemInputs).forEach((e=>{t[e]=this.addingItemInputs[e].value})),t}getItemDiv(t={},e){var n,i;const r=[],o={};let l=null;for(const c of this.properties){void 0===t[c.name]&&(t[c.name]=null);const h=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](t):s.input.forProperty(c,t),u=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];u&&h.addValidator(u),r.push(this.options.horizontalInputNames?h.root:this.hideLabel(h.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&h.input&&(h.input.style.width="100%"),o[c.name]=h,h.onChanged.subscribe((()=>{t[c.name]=h.value,e?this.onAddingItemChanged.next({item:t,fieldName:c.name}):this.onItemChanged.next({item:t,fieldName:c.name})})),h.root.style.alignItems="center",l=h}let c=null;if(e)this.addingItemInputs=o,c=s.icons.add((()=>{const t=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(o).forEach((e=>{t[e]=o[e].value})),this._items.push(t),this.onItemAdded.next(t),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return r;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(t),1),this.onItemRemoved.next(t),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",r}hideLabel(t){return t.getElementsByTagName("label")[0]&&t.removeChild(t.getElementsByTagName("label")[0]),t}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const wn={A:new V.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new V.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new V.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new V.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new V.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new V.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new V.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new V.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new V.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new V.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new V.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new V.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},Cn={RNA:{A:new V.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new V.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new V.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:wn};async function An(t,e,n=0){if(!Object.keys(Cn).includes(e))return null;const i=await async function(t){const e=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!e)return null;try{const n=(await e.apply({molString:t}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(t){return null}}(t);if(!i)return null;if(!Cn[e])return null;const r=Cn[e];let o=0,s=null;for(const[t,e]of Object.entries(r)){const r=(0,O.$1)(i,e);r>o&&r>=n&&(o=r,s=t)}return s}var Sn,xn=n(857),En={};En.styleTagTransform=A(),En.setAttributes=b(),En.insert=g().bind(null,"head"),En.domAPI=m(),En.insertStyleElement=w(),d()(xn.A,En),xn.A&&xn.A.locals&&xn.A.locals,function(t){t.MONOMER="Monomer",t.SYMBOL="Symbol",t.NAME="Name",t.R_GROUPS="~R-Groups",t.MONOMER_TYPE="Monomer Type",t.POLYMER_TYPE="Polymer Type",t.NATURAL_ANALOG="Natural Analog",t.AUTHOR="Author",t.CREATE_DATE="Create Date",t.ID="ID",t.META="Meta",t.SOURCE="Source"}(Sn||(Sn={}));const Mn={[Sn.MONOMER]:a.COLUMN_TYPE.STRING,[Sn.SYMBOL]:a.COLUMN_TYPE.STRING,[Sn.NAME]:a.COLUMN_TYPE.STRING,[Sn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Sn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Sn.AUTHOR]:a.COLUMN_TYPE.STRING,[Sn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Sn.ID]:a.COLUMN_TYPE.INT,[Sn.META]:a.COLUMN_TYPE.STRING,[Sn.SOURCE]:a.COLUMN_TYPE.STRING};class _n{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Sn.NAME).width=100,this.tv.grid.col(Sn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=bn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(t){this.monomerLibManamger=t,this.monomerLib=t.getBioLib(),this._newMonomerForm=new Pn(t,(()=>this.activeMonomerLib),(async t=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e,this.adjustTable(),null!=t&&setTimeout((()=>{const n=e.col(Sn.SYMBOL).toList().indexOf(t);-1!==n&&(this.tv?.grid.scrollToCell(e.columns.byIndex(0),n),e.currentRow=e.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const t=await pn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.instance=new _n(t)}return this.instance}static async getNewInstance(){const t=await pn.getInstance();return await t.awaitLoaded(),await t.loadLibrariesPromise,new _n(t)}async createNewMonomerLib(t,e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(e.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,t),await o.dapi.files.writeAsText(hn.so+t,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(t)}catch(t){o.shell.error("Error creating library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(t){const e=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const t=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!t)}});function i(t){return t&&t.trim()?t.endsWith(".json")&&e.includes(t)||e.includes(t+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const e=i(n.value);if(e)o.shell.warning(e);else{try{await this.createNewMonomerLib(function(){let t=n.value;return t.endsWith(".json")||(t+=".json"),t}(),t??[])}catch(t){o.shell.error("Error creating library"),console.error(t)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(t,e=!0){const n=await this.getMonomersDf(t);return this.tv=a.TableView.create(n,e),this.adjustTable(),this.tv.subs.push(o.events.onContextMenu.subscribe((({args:t})=>{if(!t||!t.menu||!t.context||t.context.type!==a.VIEWER.GRID||!t.context.tableView||t.context.tableView.id!==(this.tv.id??"")||!t.item||!t.item.isTableCell||(t.item.tableRowIndex??-1)<0)return;const e=t.item.tableRowIndex;t.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(e))})),this.tv.dataFrame.selection.trueCount>0?(t.menu.item("Remove Selected Monomers",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>Gn(this.tv.dataFrame.rows.get(t)))));this._newMonomerForm.removeMonomers(t,this.libInput.value)})),t.menu.item("Selection To New Library",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>Gn(this.tv.dataFrame.rows.get(t)))));this.createNewLibDialog(t)}))):t.menu.item("Remove Monomer",(async()=>{const t=await Gn(this.tv.dataFrame.rows.get(e));this._newMonomerForm.removeMonomers([t],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter((t=>t.name===_n.VIEW_NAME)).forEach((t=>t.close()))}findActiveManagerView(){if(!this.tv)return null;const t=Array.from(o.shell.tableViews??[]).find((t=>t.id===this.tv.id));return t?o.shell.v=t:_n.closeAllMonomerManagers(),t??null}_skipLibInputOnchange=!1;async getViewRoot(t,e=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),e&&(this.tv=this.findActiveManagerView())&&(t??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),t&&(this.libInput.value=t)}catch(t){o.shell.error("Error updating library list"),console.error(t)}finally{this._skipLibInputOnchange=!1}const e=await this.getMonomersDf(t);return this.tv.dataFrame=e,this.adjustTable(),this.tv}t??=n[0],this.tv=await this.getMonomersTableView(t,e);let i=this.tv.getRibbonPanels();i.forEach(((t,e)=>{i[e]=t.filter((t=>0!==t.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((t=>t.length>0));const r=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),c=s.icons.delete((async()=>{const t=this.tv?.dataFrame?.currentRowIdx??-1,e=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(t<0&&0===e.length)return;if(e.length>0){const t=await Promise.all(e.map((t=>Gn(this.tv.dataFrame.rows.get(t)))));return void await this._newMonomerForm.removeMonomers(t,this.libInput.value)}const n=await Gn(this.tv.dataFrame.rows.get(t));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(c,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const h=s.iconFA("arrow-to-bottom",(async()=>{const t=this.libInput.value;if(!t)return o.shell.error("No library selected");let e=null;try{e=await o.dapi.files.readAsText(hn.so+t)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}if(!e)return o.shell.error(`Library ${t} is empty`);a.Utils.download(t,e,"text/plain")}),"Download Monomer Library");i.push([r,l,c,h]),this.tv.setRibbonPanels(i),this.tv.name=_n.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:t,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const t=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=t,this.adjustTable()}catch(t){console.error(t)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const u=this._newMonomerForm.form;return u.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(u,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(t){return this._newMonomer=await Gn(t),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(t??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(hn.so,t),!this.activeMonomerLib)return o.shell.error(`Library ${t} not found`),a.DataFrame.create();const e=this.activeMonomerLib.getPolymerTypes().flatMap((t=>this.activeMonomerLib.getMonomerSymbolsByType(t).map((e=>this.activeMonomerLib.getMonomer(t,e))))),n=a.DataFrame.create(e.length),i=new Set;for(const t of e)t.rgroups.forEach((t=>{t.label&&i.add(t.label)}));const r=Array.from(i);r.sort();for(const[t,e]of Object.entries(Mn))if(n.columns.addNew(t,e),t===Sn.R_GROUPS)for(const t of r)n.columns.addNew(t,a.COLUMN_TYPE.STRING);n.col(Sn.SYMBOL).semType="Monomer",n.col(Sn.SYMBOL).setTag(Rt.Mn.applyToBackground,"true");for(let t=0;t<e.length;t++){let i=Rn(e[t].rgroups,e[t].smiles,e[t].molfile);i=In(i),e[t].rgroups=Nn(e[t].rgroups);const o=r.map((n=>{const i=e[t].rgroups.find((t=>t.label===n));return i?Ln(i,"capGroupSmiles"):""}));let s=null;if(e[t].createDate)try{s=Date.parse(e[t].createDate)}catch(n){console.error(`Error parsing date ${e[t].createDate}`)}n.rows.setValues(t,[i,e[t].symbol,e[t].name,JSON.stringify(e[t].rgroups??[]),...o,e[t].monomerType,e[t].polymerType,e[t].naturalAnalog,e[t].author,s,e[t].id,JSON.stringify(e[t].meta??{}),e[t].lib?.source??""]);try{s&&n.col(Sn.CREATE_DATE)?.set(t,s,!1)}catch(n){console.error(`Error setting date ${e[t].createDate}`)}}return n.col(Sn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((t=>{n.col(t).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((async t=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;await this.editMonomer(n.rows.get(n.currentRowIdx))}catch(t){console.error(t)}})),n}catch(t){throw o.shell.error("Error creating monomers dataframe"),console.error(t),t}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function In(t){let e=t.replaceAll(/\[R[1-9]\]/g,(t=>`[*:${t[2]}]`));return e=e.replaceAll(/\[\d\*\]/g,(t=>`[*:${t[1]}]`)),e.replaceAll(/\[\d\*\:\d\]/g,(t=>`[*:${t[1]}]`))}const Tn=["alternateId","capGroupName","capGroupSMILES","label"];function Ln(t,e){const n=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));if(n)return t[n]}function Nn(t){return t.map((t=>{const e=function(t,e){const n={};return t.forEach((t=>{const i=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));i&&(n[t]=e[i])})),n}(Tn,t),n=Ln(e,"capGroupSMILES"),i=Ln(e,"alternateId"),r=Ln(e,"capGroupName"),o=Ln(e,"label")??"R1";if(n&&i&&r||o.length<2)return e;if(i&&-1!==i.indexOf(`${o}-`)){const t=i.replace(`${o}-`,"");r||(e.capGroupName=t),n||(e.capGroupSMILES=`[*:${o.substring(1)}][${t}]`)}else r&&(n||(e.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(e.alternateId=`${o}-${r}`));return e})).sort(((t,e)=>t.label?.localeCompare(e.label??"")??0))}class Pn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(t){this._molChanged=t}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(t,e,n,i){this.monomerLibManager=t,this.getMonomerLib=e,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const t=this.validateInputs();t?o.shell.warning(t):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));t&&t.header.style.removeProperty("background-color");let e=this.molSketcher.getSmiles();if(!e)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();e=Rn([],e);const n=this.findRgroupsInSmiles(e);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((t=>t[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((t=>Number.parseInt(t[0].match(/[1-9]/g)[0]))).map((t=>this.rgroupsGrid.items.find((e=>e.label===`R${t}`))??{capGroupSMILES:`[*:${t}][H]`,alternateId:`R${t}-H`,capGroupName:"H",label:`R${t}`}));this.rgroupsGrid.items=i.sort(((t,e)=>t.label?.localeCompare(e.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const r=await An(kn(e,i),this.polymerTypeInput.value??"");r&&(this.monomerNaturalAnalogInput.value=r)}catch(t){console.error(t)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new vn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:t=>t?o.chem.checkSmiles(t)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:t=>t?null:"Alternate ID is required",capGroupName:t=>t?null:"Cap group name is required",label:t=>t?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new vn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const t=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=t?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(t){this.triggerMolChange=!1,this.molSketcher.setSmiles(t.smiles),this.polymerTypeInput.value=t.polymerType,this.monomerTypeInput.value=t.monomerType,this.monomerSymbolInput.value=t.symbol,this.monomerNameInput.value=t.name,this.monomerIdInput.value=t.id,this.monomerNaturalAnalogInput.value=t.naturalAnalog??null,this.rgroupsGrid.items=Nn(t.rgroups),this.metaGrid.items=Object.entries(t.meta??{}).filter((([t,e])=>"colors"!==t?.toLowerCase())).map((([t,e])=>({Property:t,Value:e}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!t.naturalAnalog&&t.polymerType&&An(kn(t.smiles,this.rgroupsGrid.items),t.polymerType).then((t=>{t&&(this.monomerNaturalAnalogInput.value=t)}));const e=t.meta?.colors??"";let n={};try{n=e?JSON.parse(e)?.default:{}}catch(t){console.error(t)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));if(t&&t.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const t of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==t.value||""===t.value)return`${t.caption} field is required`;let e=null;if(this.rgroupsGrid.items.length<1&&(e="At least one R-group is required"),!e)t:for(const t of this.rgroupsGrid.items)for(const[n,i]of Object.entries(t))if(!i){e=`R-group ${n} field is required for ${t.label}`;break t}return!e&&this.rgroupsGrid.hasErrors()&&(e="R-group fields contain errors"),e?(t&&t.header.style.setProperty("background-color","#ff000030"),e):null}findRgroupsInSmiles(t){return[...Array.from(t.matchAll(/\[[1-9]\*\]/g)),...Array.from(t.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const t=s.buttonsInput([this.saveButton]);return s.tooltip.bind(t,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,t],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(t){const e=Rn(t.rgroups,t.smiles,t.molfile),n=o.chem.drawMolecule(e,150,150),i=s.tableFromMap({name:t.name,author:t.author,createDate:t.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(t,e,n=!0){let i=[];try{const t=await o.dapi.files.readAsText(hn.so+e);i=JSON.parse(t)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}const r=t.map((t=>$n(i,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${t[n].symbol} not found in library ${e}`);const a=r.map((t=>i[t])),l=s.divV(a.map((t=>this.getMonomerInfoTable(t))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((t=>t.symbol)).join(", ")} from ${e} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${e} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((t=>!a.includes(t))),await o.dapi.files.writeAsText(hn.so+e,JSON.stringify(i,null,2)),await(await pn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((t=>t.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${e} library`),u.close()})).show()}async addMonomerToLib(t,e){let n=[];try{const t=await o.dapi.files.readAsText(hn.so+e);n=JSON.parse(t)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}const i=$n(n,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType)),r=this.getMonomersDataFrame()?.col(Sn.MONOMER)?.toList()?.findIndex((e=>e===t.smiles)),a=async()=>{try{const i=n.findIndex((e=>e.symbol===t.symbol&&e.polymerType===t.polymerType));i>=0?n[i]={...t,lib:void 0,wem:void 0}:n.push({...t,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText(hn.so+e,JSON.stringify(n,null,2)),await(await pn.getInstance()).loadLibraries(!0),await this.refreshTable(t.symbol),this._molChanged=!1,o.shell.info(`Monomer ${t.symbol} was successfully saved in library ${e}`)}catch(t){o.shell.error("Error saving monomer"),console.error(t)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${t.symbol}' already exists in library ${e}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const t=await Gn(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(t),c=`Monomer with the same structure already exists in library ${e} with different symbol (${t.symbol}).\nAre you sure you want to duplicate it?`}if(l){const t=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{t.close(),a()})).show()}else await a()}async saveMonomer(){let t=this.molSketcher.getSmiles();if(!t||!o.chem.checkSmiles(t))return void o.shell.warning("Invalid SMILES");t=Rn([],t);let e=o.chem.convert(t,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);e=On(e);const n={};this.metaGrid.items.filter((t=>!!t.Property&&!!t.Value)).forEach((t=>{n[t.Property]=t.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:e,smiles:t,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(r,s):o.shell.warning("Monomer library source is not specified")}}function $n(t,e){let n=-1;for(let i=t.length-1;i>=0;i--)if(e(t[i])){n=i;break}return n}function Rn(t,e,n){const i=!e||!o.chem.checkSmiles(e);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):e;return r=function(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=new RegExp(`\\[\\${t.capGroupName}:${e}\\]`,"g");n=n.replace(i,`[*:${e}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(t=>`[*:${t[1]}]`)),n}(r,t),r=In(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function On(t){const e=t.split("\n"),n=e.findIndex((t=>t.startsWith("M")&&t.includes("ISO")));if(-1!==n){const t=e[n].indexOf("ISO");e[n]=e[n].substring(0,t)+"RGP"+e[n].substring(t+3)}const i=e.findIndex((t=>t.includes("V2000")||t.includes("V3000"))),r=Number.parseInt(e[i].trim().split(" ")[0]),o={};for(let t=i+1;t<i+1+r;t++){const n=e[t].indexOf("R ");if(-1===n)continue;"#"!==e[t][n+1]&&(e[t]=e[t].replace("R ","R#"));const r=e[t].trim().split(" ").map((t=>t.trim())).filter(Boolean);if(o[t-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[t-i]=s)}const s=Object.keys(o);if(-1===e.findIndex((t=>t.startsWith("M")&&t.includes("RGP")))){const t=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(o).map((([t,e])=>`${t.toString().padStart(4," ")}${e.toString().padStart(4," ")}`)).join("")}`,n=e.findIndex((t=>t.startsWith("M")&&t.includes("END")));e.splice(n,0,t)}return s.filter((t=>!!Number.parseInt(t))).map((t=>Number.parseInt(t)+i)).forEach((t=>{const n=e[t].split(" "),i=n.findIndex((t=>"R#"===t));if(-1!==i){for(let t=i+1;t<n.length;t++)n[t]&&1==n[t].length&&(Number.parseInt(n[t])??0)>0&&(n[t]="0");e[t]=n.join(" ")}})),e.join("\n")}function kn(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=Ln(t,"capGroupName");n=n.replace(`[*:${e}]`,`[${i}]`)})),n}async function Gn(t){let e;try{e=JSON.parse(t.get(Sn.META)??"{}");for(const t in e)"object"==typeof e[t]&&(e[t]=JSON.stringify(e[t])),("string"!=typeof e[t]||e[t]!==a.INT_NULL.toString()&&e[t]!==a.FLOAT_NULL.toString())&&("number"!=typeof e[t]||e[t]!==a.INT_NULL&&e[t]!==a.FLOAT_NULL)||(e[t]=null)}catch(t){console.error(t)}const n=t.get(Sn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=On(i)}catch(t){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(t)}let r=t.get(Sn.NATURAL_ANALOG);const s=t.get(Sn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(t.get(Sn.R_GROUPS)??"[]"),!r&&s){const t=await An(kn(n,l),s);t&&(r=t)}}catch(t){l??=[]}return{symbol:t.get(Sn.SYMBOL),name:t.get(Sn.NAME),molfile:i,smiles:n,polymerType:s,monomerType:t.get(Sn.MONOMER_TYPE),naturalAnalog:r,id:t.get(Sn.ID),rgroups:l,meta:e,author:t.get(Sn.AUTHOR),createDate:t.get(Sn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(t){this._colors=t,this._colorInputs={line:s.input.color("Line",{value:t.line,onValueChanged:t=>this._colors.line=t}),background:s.input.color("Background",{value:t.background,onValueChanged:t=>this._colors.background=t}),text:s.input.color("Text",{value:t.text,onValueChanged:t=>this._colors.text=t})}}get colors(){return this._colors}set colors(t){const e={line:a.Color.toHtml(a.Color.fromHtml(t.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(t.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(t.text??"#000000"))};this._colors=e;for(const t in this._colorInputs)this._colorInputs[t].value=e[t]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Hn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(t){this._selected=t,this.root.style.border=t?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(t){this.monomer=t}render(){s.empty(this.root);const t=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(t);const e=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(e),s.tooltip.bind(e,this.monomer.name),this.monomer.lib?.source){const t=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(t),s.tooltip.bind(t,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Bn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(t,e,n,i){this.monomerSymbol=t,this.monomers=e,this.monomerCards=e.map((t=>new Hn(t)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(t,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,t),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((t=>{t.root.onclick=()=>{this.monomerCards.forEach((t=>t.selected=!1)),t.selected=!0,i(t.monomer)},n&&t.monomer===n&&(t.selected=!0),r.appendChild(t.root)}))}render(){this.monomerCards.forEach((t=>t.render()))}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await pn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Dn._instance.refresh()))),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Nt.ub)();const t=await pn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.monomers=t.duplicateMonomers,this.monomerCardRows=[];for(const e in this.monomers)for(const n in this.monomers[e]){const i=this.settings.duplicateMonomerPreferences?.[e]?.[n]??null,r=i?this.monomers[e][n].find((t=>t.lib?.source===i))??null:null;this.monomerCardRows.push(new Bn(n,this.monomers[e][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][n]=i.lib.source,await(0,Nt.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),t.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(t=>(this.monomerCardRows[t].render(),this.monomerCardRows[t].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>t(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const t=t=>{this.filteredMonomerRows=this.monomerCardRows.filter((e=>e.monomerSymbol.toLowerCase().includes(t.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)))}}}constructor(){}get root(){return this._root}}async function Vn(){await qn.showDialog()}async function jn(t=!0){return await zn.showView(t)}class Un{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Un.instancePromise&&(Un.instancePromise=(async()=>{const t=new Un,e=await(0,bt.pj)();return t._fileManager=await e.getFileManager(),t._widget=await t.createWidget(),t})()),Un.instancePromise}static async reloadWidget(){const t=await Un.getInstance();t._widget=await t.createWidget()}async createWidget(){const t=await this.getWidgetContent();return(await(0,bt.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(t)}async getWidgetContent(){const t=await Wn.createControlsForm();return fn()(t).addClass("monomer-lib-controls-form"),setTimeout((()=>{t&&fn()(t)&&fn()(t).removeClass("ui-form-condensed")}),200),s.divV([t])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async t=>{const e=await t.text(),n=t.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(e,n)}catch(t){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Wn{fileManager;userLibSettings;constructor(t,e){this.fileManager=t,this.userLibSettings=e,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([t,e])=>{this.updateLibrarySelectionStatus(e,t)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Di.logger.debug("LibraryControlsForm.createControlsForm(), start");const[t,e]=await Promise.all([(0,bt.pj)().then((t=>t.getFileManager())),await(0,Nt.ub)()]);return new Wn(t,e)._createControlsForm()}_createControlsForm(){const t=this.createLibraryControls(),e=s.wideForm(t,void 0);return fn()(e).addClass("monomer-lib-controls-form"),e}updateControlsForm(){const t=this._createControlsForm();fn()(".monomer-lib-controls-form").replaceWith(t)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((t=>this.createLibInput(t)))}createLibInput(t){const e=`${this.toLog()}.createLibInput()`;Di.logger.debug(`${e}, libFileName = '${t}', start`);const n=!this.userLibSettings.exclude.includes(t),i=s.input.bool(t,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(t,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${t}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(t))),a=s.icons.edit((async()=>{o.shell.v=await(await _n.getInstance()).getViewRoot(t)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${t}`),i.addOptions(a),i.addOptions(r),Di.logger.debug(`${e}, libFileName = '${t}', end`),i}async updateLibrarySelectionStatus(t,e){this.updateLibrarySettings(t,e),await(0,Nt.Eu)(this.userLibSettings);const n=await(0,bt.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(t,e){t?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((t=>t!==e)):this.userLibSettings.exclude.includes(e)||this.userLibSettings.exclude.push(e)}promptForLibraryDeletion(t){s.dialog("Warning").add(s.divText(`Delete file ${t}?`)).onOK((async()=>{try{const e=a.TaskBarProgressIndicator.create(`Deleting ${t} library`);await this.updateLibrarySelectionStatus(!1,t),await this.fileManager.deleteLibraryFile(t),e.close()}catch(e){console.error(e),o.shell.error(`Failed to delete ${t} library`)}})).showModal(!1)}}class qn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){qn._instance||(qn._instance=new qn,qn._instance.closeDialogSubject$.subscribe((()=>{qn._instance.dialog=void 0}))),qn._instance.dialog||(qn._instance.dialog=await qn._instance.getDialog()),qn._instance.dialog.show()}async getDialog(){const t=dn.getInstance(),e=(await Un.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});fn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>t.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class zn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(t=!0){const e=dn.getInstance(),n=(await Un.getInstance()).widget,i=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),r=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,r])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);return this._view=a.View.fromRoot(l),this._view.name=zn.viewName,t&&o.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const t=Array.from(l.children).filter((t=>t.classList.contains("ui-box")));if(2!==t.length)return;const[e,n]=t,i=e.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;e.style.width=`${r}px`;const o=i-r;n.style.width=`${o}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((()=>{try{const t=zn._instance;t&&t._view&&"id"in o.shell.v&&o.shell.v.id===t._view.id&&t._duplicateManager?.refresh()}catch(t){console.error(t)}})))})),this._view}static async showView(t=!0){return zn._instance||(zn._instance=new zn),zn._instance._duplicateManager||(zn._instance._duplicateManager=await Dn.getInstance()),zn._instance.libManager||(zn._instance.libManager=await pn.getInstance()),t&&zn._instance._view&&Array.from(o.shell.views).find((t=>t.id&&t.id===zn._instance._view.id))?(o.shell.v=zn._instance._view,await zn._instance._duplicateManager.refresh(),zn._instance._view):(zn.closeExistingViews(),zn._instance.getView(t))}static closeExistingViews(){Array.from(o.shell.views).filter((t=>t.name===zn.viewName)).forEach((t=>t.close()))}async mergeSelectedLibs(){const t="Library with this name already exists",e=await pn.getInstance();if(await e.awaitLoaded(),await e.loadLibrariesPromise,!e.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=e.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const e=h(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!e&&e!==t),i.getButton("Save")?.classList?.toggle("d4-disabled",!!e)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let t=r.value;return t.endsWith(".json")||(t+=".json"),t}function h(e){return e&&e.trim()?e.endsWith(".json")&&l.includes(e)||l.includes(e+".json")?t:null:"Library name cannot be empty"}r.addValidator(h),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const t=c(),e=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(e,t,!1);const n=await(0,Nt.ub)();n.exclude=l,await(0,Nt.Eu)(n),await this.libManager.loadLibraries(!0),await Un.reloadWidget()}catch(e){o.shell.error(`Failed to save library ${t}. see console for details.`),console.error(e)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Yn,Kn=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};class Zn{_setBreadcrumbsInViewName(){var t,e;const n=["Home","Demo",...(null!==(t=this._path)&&void 0!==t?t:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((t=>Kn(this,void 0,void 0,(function*(){const e=t[t.length-1];if(e===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===e?n:n.items.find((t=>t.text===e))})))),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const t=s.iconFA("home",(()=>{o.shell.v.close(),o.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));t.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(t)}const t=null===(e=o.shell.v.ribbonMenu.root.parentElement)||void 0===e?void 0:e.getElementsByClassName("d4-ribbon-name")[0];t&&(t.textContent="",t.appendChild(i.root))}}constructor(t,e,n=!1,i){var r,o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Kn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._path=null!==(o=null==i?void 0:i.path)&&void 0!==o?o:"",this._progress.max=0,this._progress.value=1,Zn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var t;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(t=this._path)&&void 0!==t?t:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Kn(this,void 0,void 0,(function*(){var t,e;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(t){console.error(t)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,te.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof a.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Kn(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Kn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){return Kn(this,void 0,void 0,(function*(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Kn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Zn.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Kn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Zn.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Yn||(Yn={}));var Xn=n(966),Jn=n(608),Qn=n(1619);class ti{urlParams;funcName;options;df;view;constructor(t,e,n={}){this.urlParams=t,this.funcName=e,this.options=n}async init(t){this.df=t,await this.buildView()}async buildView(){const t=rt()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}?${t}`;const e={...this.options,sequenceColumnName:"sequence"};for(const[t,n]of this.urlParams.entries())switch(t){case re.n5.fixWidth:case re.n5.fitArea:e[t]=["1","on","true"].includes(n.toLowerCase());break;default:e[t]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ei{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const t=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:t,filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ni=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};class ii extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,r,o,s){t.save();try{if(!o.isTableCell)return;const s=o.cell?.column&&o.cell.column?.dart&&"true"===o.cell.column.getTag(Rt.Mn.applyToBackground);t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=o.cell.value;if(!a||a==wt._S)return;let l=Ot.S$,c="rgb(255, 255, 255)";if(this.monomerLib){const t=this.tableCol.getTag(wt.gp.alphabet),e=t===gt.YI.RNA||t===gt.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA;if(s){const t=this.monomerLib.getMonomerColors(e,a);l=t?.textcolor??l,c=t?.backgroundcolor??c}else l=this.monomerLib.getMonomerTextColor(e,a)}const h=Math.max(2,Math.floor(.15*i));s&&(t.fillStyle=c,t.fillRect(e,n,i,r)),t.fillStyle=l,t.fillText((0,gt.zS)(a,h),e+i/2,n+r/2,i)}finally{t.restore()}}onMouseMove(t,e){if(t.grid.dart!=this.gridCol?.grid.dart||t.gridColumn.dart!=this.gridCol?.dart||!t.tableColumn||!t.isTableCell)return!1;const n=t.tableColumn.getTag(wt.gp.alphabet),i=t.cell.value,r=t.grid.canvas.getBoundingClientRect(),o=t.bounds.right+r.left-4,a=t.bounds.bottom+r.top-4;if(i==wt._S)return s.tooltip.show(s.divText("gap"),o,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),o,a),!0;const l=n===gt.YI.RNA||n===gt.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA,c=this.monomerLib.getTooltip(l,i);return s.tooltip.show(c,o,a),!0}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Ft.BG)(t);let r=i.rendererBack;return r||(r=i.rendererBack=new ii(e,n)),r}}class ri extends a.GridCellRenderer{get name(){return jt.uF.MONOMER}get cellType(){return jt.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,n,i,r,o,s){ii.getOrCreate(o).render(t,e,n,i,r,o,s)}onMouseMove(t,e){ii.getOrCreate(t).onMouseMove(t,e)}}class oi{constructor(t,e,n=""){this.target=t,this.debugEnabled=e,this.prefix=n}error(t,e,n){return this.target.error(this.prefix+t,e,n)}warning(t,e){return this.target.warning(this.prefix+t,e)}info(t,e){return this.target.info(this.prefix+t,e)}debug(t,e){if(this.debugEnabled)return this.target.debug(this.prefix+t,e)}}class si extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const t=super.get("FontSize");return t&&!isNaN(t)?Number.parseInt(t):12}set fontSize(t){super.set("FontSize",t),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const t=super.get("MaxMonomerLength");return"long"===t?null:parseInt(t)}set maxMonomerLength(t){const e=null===t?"long":t.toString();super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(t){this._properties=t}_initialized=!1;get initialized(){return this._initialized}constructor(t={debug:!1}){super(),super._logger=new oi(super.logger,t.debug)}completeInit(t,e,n,i){this._seqHelper=t,this._monomerLib=e,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(t){const[e,n]=(0,Ct.AP)(t);o.shell.error(e),this.logger.error(e,void 0,n)}}var li=n(2174);class ci extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(t,e){super(s.divV([])),this.seqCol=t,this.seqHelper=e}async init(){const t=this.seqHelper.getSeqHandler(this.seqCol),e=Di.properties.tooltipWebLogo,n=this.seqCol.getTag(ee.gp.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function hi(t,e,n,i){const r=Di.seqHelper.getSeqHandler(t);let o=null,s=null;for(let t=0;t<r.posList.length;++t)r.posList[t]==e&&(o=t),r.posList[t]==n&&(s=t);if(null===o&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${n??""})`;return r.getRegion(o,s,a)}const ui={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(gt.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class di{urlParams;funcName;view;data;constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??ui;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(gt.gp.positionNames,this.data.positionNames),this.data.regions&&e.setTag(gt.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class pi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(t,e){this.call=t,this.seqHelper=e;const n=t=>this.call.inputParams[t].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const t in this.call.inputParams)s.tooltip.bind(this.inputs[t].captionLabel,n(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&this.seqHelper.getSeqHandler(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?this.seqHelper.getSeqHandler(t):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),r=document.createElement("option");e.text=r.text=t,e.value=r.value=t,n.options.add(e),i.options.add(r)}n.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(gt.gp.regions):null,n=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const t of n){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const r=t.options[i],o=JSON.parse(r.value);o&&e===o.start&&n===o.end&&(t.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=e?`${n.name}(${e.name}): ${e.start}-${e.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(t).onOK((()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Di.handleErrorUI(t)}))})).show()}widget(){const t=s.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=s.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Di.handleErrorUI(t)}))}));return a.Widget.fromRoot(s.divV([t,s.div(e)]))}}var mi=n(8754);async function fi(t,e,n,i,r){const o=await async function(t,e,n,i,r){const o=(0,vt.R)(e,r),s=r.getSeqHandler(e).getNewColumnFromList("ref",[n]),l=r.getSeqHandler(s).getSplitted(0),c=i===ft.IDENTITY?function(t,e){const n=e.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=e.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<t.length?t.getOriginal(s):wt._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",e.rowCount),l=s.getRawData();for(let n=0;n<e.rowCount;++n){l[n]=0;for(let e=0;e<t.length;++e)(i[e]?i[e][n]:0)===o[e]&&++l[n];l[n]/=t.length}return s}(l,o):i===ft.SIMILARITY?await async function(t,e,n){const i=e.columns.toList();return await(0,bt.uL)(i,t,n)}(l,o,r):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=t.columns.getUnusedName(c.name),t.columns.add(c),c}(t,e,n,i,r);for(let t=0;t<o.length;t++)e.isNone(t)&&o.set(t,null,!1);return o}var gi=n(294),yi=n(330);const bi=OCL;var vi=n(9099);class wi{monomerSymbol;constructor(t){this.monomerSymbol=t}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const t=this.rGroups.getAtomicIdx(1);if(null===t)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:e,y:n}=this.atoms.atomCoordinates[t];this.atoms.shift({x:-e,y:-n})}alignR2AlongX(){const t=this.rGroups.getAtomicIdx(2);if(null===t)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const e=this.atoms.atomCoordinates[t],n=e.y/e.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(t){this.rGroups.deleteBondLineWithSpecifiedRGroup(t)}shiftCoordinates(t){this.atoms.shift(t)}rotateCoordinates(t){this.atoms.rotate(t)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(t){this.rGroups.removeRGroups(t)}replaceRGroupWithAttachmentAtom(t,e){this.rGroups.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.rGroups.getAttachmentAtomIdByRGroupId(t)}shiftBonds(t){this.bonds.shift(t)}capRGroups(t){this.rGroups.capRGroups(t)}}var Ci=n(6956);class Ai{atoms;bonds;constructor(t,e,n){this.atoms=e,this.bonds=n,this.rGroupIdToAtomicIndexMap=t.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(t){const e=this.rGroupIdToAtomicIndexMap.get(t);return void 0===e?null:e}removeRGroupsFromAtomBlock(t){t.forEach((t=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(t))throw new Error(`Cannot find atomic index for R group ${t}`)}));const e=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([e,n])=>t.includes(e))).map((([t,e])=>e));this.atoms.deleteAtoms(e)}removeRGroups(t){this.removeRGroupsFromAtomBlock(t),t.forEach((t=>{const e=this.replaceRGroupInBondsByDummy(t);this.rGroupBondPositionMap.set(t,e)}))}replaceRGroupInBondsByDummy(t){const e=this.rGroupIdToAtomicIndexMap.get(t);if(this.rGroupBondPositionMap.has(t))throw new Error(`R group ${t} is already handled`);const n=this.bonds.getPositionsInBonds(e+1);if(0===n.length)throw new Error(`Cannot find position for R group ${t}`);if(n.length>1)throw new Error(`More than one position for R group ${t}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(e+1),this.removeRGroupFromAtomicIdxMap(t,e),i}removeRGroupFromAtomicIdxMap(t,e){this.rGroupIdToAtomicIndexMap.delete(t);for(const[t,n]of this.rGroupIdToAtomicIndexMap)n>e&&this.rGroupIdToAtomicIndexMap.set(t,n-1)}deleteBondLineWithSpecifiedRGroup(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n}=e;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(t),this.rGroupIdToAtomicIndexMap.delete(t),this.rGroupBondPositionMap.forEach((t=>{t.bondLineIdx>n&&(t.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(t,e){const n=this.rGroupBondPositionMap.get(t);if(!n)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=e}getAttachmentAtomIdByRGroupId(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n,nodeIdx:i}=e;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(t){this.rGroupIdToAtomicIndexMap.forEach(((e,n)=>{const i=t[n-1];i===Ci.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(e,i)}))}}class Si{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(t,e){this.rawAtomLines[t]=this.rawAtomLines[t].replace("R#",e)}deleteAtoms(t){this.coordinates=this.coordinates.filter(((e,n)=>!t.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((e,n)=>!t.includes(n)))}shift(t){this.coordinates=this.coordinates.map((e=>{const n=e.x+t.x,i=e.y+t.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${t.x}, ${t.y}`);return{x:n,y:i}}))}rotate(t){this.coordinates=this.coordinates.map((e=>{const n=e.x,i=e.y,r=n*Math.cos(t)-i*Math.sin(t),o=n*Math.sin(t)+i*Math.cos(t);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${t}`);return{x:r,y:o}}))}}class xi extends Si{constructor(t){super(),this.rawAtomLines=t.getAtomLines(),this.coordinates=this.rawAtomLines.map((t=>({x:parseFloat(t.substring(0,10)),y:parseFloat(t.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((t,e)=>{const n=this.coordinates[e];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${t.substring(20)}`}))}}class Ei{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(t){this.rawBondLines=this.rawBondLines.filter(((e,n)=>!t.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((e,n)=>!t.includes(n)))}getPositionsInBonds(t){const e=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===t&&e.push({bondLineIdx:i,nodeIdx:r})}))})),e}replacePositionsInBondsByDummy(t,e){void 0===e&&(e=-1),t.forEach((t=>{const{bondLineIdx:n,nodeIdx:i}=t;this.bondedAtomPairs[n][i]=e}))}removeAtomIdFromBonds(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e>t?e-1:e))))}shift(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e+t))))}}class Mi extends Ei{constructor(t){super(),this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((t=>[parseInt(t.substring(0,3)),parseInt(t.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((t,e)=>{if(t.some((t=>-1===t)))throw new Error(`Bonded pair ${t} contains -1`);return`${t[0].toString().padStart(3," ")}${t[1].toString().padStart(3," ")}${this.rawBondLines[e].substring(6)}`}))}}class _i extends wi{constructor(t,e){super(e);const n=Re.getInstance(t);this.atoms=new xi(n),this.bonds=new Mi(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends Si{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawAtomLines=t.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const t=this.molfileHandler.x,e=this.molfileHandler.y;return Array.from(t).map(((t,n)=>({x:t,y:e[n]})))}get atomLines(){const t=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,e=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(t,((t,e,n,i,r,a)=>e+o+i+s+a)).replace(e,"")}))}replaceRGroupSymbolByElement(t,e){super.replaceRGroupSymbolByElement(t,e);const n=this.rawAtomLines[t].substring(3).split(" ");n.length>7&&(this.rawAtomLines[t]=`M  ${n.slice(0,7).join(" ")}`)}}class Ti extends Ei{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((t=>[t[0],t[1]]))}getBondLines(){const t=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((e,n)=>{if(e.some((t=>-1===t)))throw new Error(`Bonded pair ${e} contains -1`);return this.rawBondLines[n].replace(t,((t,n,i,r,o,s)=>`${n}${e[0]}${r}${e[1]}${s}`))}))}}class Li extends wi{constructor(t,e){super(e);const n=Re.getInstance(t);this.atoms=new Ii(n),this.bonds=new Ti(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni{static getInstance(t,e){if(Re.isMolfileV2K(t))return new _i(t,e);if(Re.isMolfileV3K(t))return new Li(t,e);throw new Error("Unsupported molfile version")}}class Pi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(t,e,n,i,r,o){this.monomerSymbol=t,this.monomerIdx=e,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;Re.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,t,r)),this.molfileWrapper=Ni.getInstance(a,t),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[e]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(t,e,n){if(Pi.molfileV2KToV3KCache.has(t))return Pi.molfileV2KToV3KCache.get(t);let i=null;try{if(i=n.get_mol(t,JSON.stringify({mergeQueryHs:!0})),i){const e=i.get_v3Kmolblock();return Pi.molfileV2KToV3KCache.set(t,e),e}throw new Error(`Cannot convert ${e} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const t=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),e=this.monomerLib.getMonomer(t,this.monomerSymbol);if(!e)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return e}getCapGroupElements(t){return t.rgroups.map((t=>(t.capGroupSmiles||t.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(t){this.molfileWrapper.shiftCoordinates(t)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(t){this.molfileWrapper.removeRGroups(t)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(t,e){this.molfileWrapper.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.molfileWrapper.getAttachmentAtomByRGroupId(t)}deleteBondLineWithSpecifiedRGroup(t){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(t)}shiftBonds(t){this.molfileWrapper.shiftBonds(t)}}class $i{rdKitModule;monomerLib;constructor(t,e,n){this.rdKitModule=e,this.monomerLib=n,this.helm=new vi.f(t)}monomerWrappers=[];helm;addMonomer(t,e,n){if(t===wt.b9[gt.Hi.HELM])return;const i=this.monomerWrappers.length,r=new Pi(t,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(r)}getAtomNumberShifts(){const t=[];let e=0;return this.monomerWrappers.forEach((n=>{t.push(e),e+=n.getAtomLines().length})),t}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((t=>{const e=t.map((t=>t.monomerIdx)),n=t.map((t=>t.rGroupId)),i=e.map((t=>this.monomerWrappers[t])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const t=[],e=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((t,e)=>{t.shiftBonds(n[e])})),this.restoreBondsBetweenMonomers();const i=new gi.Cg;for(const[n,r]of rt().enumerate(this.monomerWrappers)){const o=t.length,s=e.length;t.push(...n.getAtomLines()),e.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(r)?Ht.o.NUCLEOTIDE:Ht.o.AA;i.set(r,{biotype:a,symbol:n.monomerSymbol,atoms:rt().count(o).take(n.atomCount).toArray(),bonds:rt().count(s).take(n.bondCount).toArray()})}const r=t.length,o=e.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(t),this.getV3KBondBlock(e),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(t,e){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${t} ${e} 0 0 1`}getV3KAtomBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,r)=>e+i+r))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,r)=>e+i+r))})),"M  V30 END BOND"].join("\n")}}class Ri{constructor(t){this.molfileHandler=Re.getInstance(t)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(t){return{x:this.molfileHandler.x[t],y:this.molfileHandler.y[t]}}}class Oi{helmHelper;rdKitModule;monomerLib;constructor(t,e,n){this.helmHelper=t,this.rdKitModule=e,this.monomerLib=n}convertToSmiles(t){const e=t.dataFrame,n=this.getSmilesList(t),i=`smiles(${t.name})`,r=e?e.columns.getUnusedName(i):i;return a.Column.fromStrings(r,n.map((t=>null===t?"":t)))}getSmilesList(t){return this.convertToMolfileV3KColumn(t).toList().map((t=>a.chem.convert(t,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(t){try{if(!t)return"";return bi.Molecule.fromMolfile(t).toMolfileV3().replace("STERAC1","STEABS")}catch(t){const[e,n]=(0,Ct.AP)(t);return Di.logger.error(e,void 0,n),""}}getMolV3000ViaOCL(t,e){const n=t.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let t=0;t<n.length;t++){i[t]=this.molV3KtoMolV3KOCL(n[t]);const e=t/n.length*100;r.update(e,`${e?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(e,i)}convertToRdKitBeautifiedMolfileColumn(t,e,n,i){const r=t.dataFrame,o=this.convertToMolfileV3KColumn(t).toList().map((t=>{if(""===t)return null;const e=n.get_mol(t);return e?(e.set_new_coords(),e.normalize_depiction(1),e.straighten_depiction(!0),e):null})),s=`molfile(${t.name})`,l=r?r.columns.getUnusedName(s):s;return e?this.getMolV3000ViaOCL(o,l):a.Column.fromStrings(l,o.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})))}convertToMolfileV3KColumn(t){const e=t.dataFrame,n=this.convertToMolfileV3K(t.toList()).map((t=>t.molfile)),i=(0,yi.kA)(e,`molfileV3K(${t.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(t){const e=new Array(t.length);for(let n=0;n<t.length;++n){const i=t[n];if(!i){e[n]=gi.vF.createEmpty();continue}let r;try{r=this.getPolymerMolfile(i)}catch(t){const[e,n]=(0,Ct.AP)(t);Di.logger.error(e,void 0,n),r=gi.vF.createEmpty()}e[n]=r}return e}getPolymerGraphColumn(t){const e=t.toList(),n=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",n)}getPolymerMolfile(t){const e=this.helmHelper.removeGaps(t),n=e.resHelm,i=new Map;for(const[t,n]of e.monomerMap?.entries()??[])i.set(n,t);const r=this.helmHelper.getMolfiles([n])[0],o=new Ri(r),s=new $i(n,this.rdKitModule,this.monomerLib);o.monomerSymbols.forEach(((t,e)=>{const n=o.getMonomerShifts(e);s.addMonomer(t,e,n)}));const a=s.compileToMolfile(),l=new gi.Cg;for(const[t,e]of a.monomers.entries()){const n=i.get(t);l.set(n,e)}return new gi.vF(a.molfile,l)}}class ki{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(t,e){if(this.seqHelper=e,t.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${a.TYPE.STRING}'.`);this._column=t;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ut.notationProvider]??null);const i=this.isFasta()?wt.b9[gt.Hi.FASTA]:this.isSeparator()?wt.b9[gt.Hi.SEPARATOR]:this.isHelm()?wt.b9[gt.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??wt.b9[gt.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(gt.gp.aligned)||!this.column.tags.has(gt.gp.alphabet)||!this.column.tags.has(gt.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===gt.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag(gt.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,e)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(gt.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(gt.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${gt.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||t.temp.seqHandlerRefined||(this.refineSeparatorNotation(),t.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const t=((t,e,n)=>{const i={};let r=!0,o=null;for(const e of t){const t=e?n(e):[];if(null===o?o=t.length:t.length!==o&&(r=!1),t.length>=3)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:r}})([...new Set((this.column.length<100?rt().count(0).take(Math.min(100,this.column.length)).map((t=>this.column.get(t))):this.column.categories.slice(0,100)).map((t=>t?t.substring(0,500):"")).filter((t=>0!==t.length)))],0,(t=>t.split(this.separator)));let e=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const r=n[0].prepare({col:this.column,stats:t,separator:this.separator}),o=(await r.call()).getOutputParamValue();e||=o}catch(t){console.error(t)}e&&(delete this.column.temp[Ut.seqHandler],this.column.fireValuesChanged())}static setTags(t){const e=t.column.meta.units;if([gt.Hi.FASTA,gt.Hi.SEPARATOR].includes(e)){if(!t.column.getTag(gt.gp.alphabet)&&0===Object.keys(t.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let e=t.column.getTag(gt.gp.aligned);null===e&&(e=t.stats.sameLength?"SEQ.MSA":"SEQ",t.column.setTag(gt.gp.aligned,e));let n=t.column.getTag(gt.gp.alphabet);if(null===n&&(n=(0,kt.pc)(t.stats.freq,gt.q7),t.column.setTag(gt.gp.alphabet,n)),n===gt.YI.UN){const e=Object.keys(t.stats.freq).length,n=Object.keys(t.stats.freq).some((t=>t.length>1));t.column.setTag(gt.gp.alphabetSize,e.toString()),t.column.setTag(gt.gp.alphabetIsMultichar,n?"true":"false")}}else if(e===gt.Hi.HELM){let e=t.column.getTag(gt.gp.alphabet);null===e&&(e=(0,kt.p0)(t.stats.freq,gt.q7,t.defaultGapOriginal),t.column.setTag(gt.gp.alphabet,e))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const t=this.column.getTag(gt.gp.separator)??void 0;if(this.notation===gt.Hi.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag(gt.gp.aligned);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag(gt.gp.alphabet);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get defaultBiotype(){return this.alphabet===gt.YI.RNA||this.alphabet===gt.YI.DNA?Ht.o.NUCLEOTIDE:Ht.o.AA}get helmCompatible(){return this.column.getTag(gt.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==gt.Hi.HELM||this.alphabet==gt.YI.UN){const t=this.column.getTag(gt.gp.alphabetSize);let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case gt.YI.PT:return 20;case gt.YI.DNA:case gt.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===gt.Hi.HELM||this.alphabet===gt.YI.UN&&"true"===this.column.getTag(gt.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(t,e){if(this.cached&&void 0===e){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let e=this._splitted[t]?this._splitted[t].deref():void 0;if(!e){const n=this.column.get(t);e=this.splitter(n),this._splitted[t]=new WeakRef(e)}return e}{const n=this.column.get(t);return this.getSplitter(e)(n)}}getValue(t,e){return this.column.get(t),new Wt(t,this)}getHelm(t){let e;const n=this.column.get(t);return e=this.notation===gt.Hi.HELM?n:this.notation===gt.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(gt.Hi.HELM)(n),e}_stats=null;get stats(){if(null===this._stats){const t={};let e=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(e=!1);for(let e=0;e<i.length;++e){const n=i.getCanonical(e);n in t||(t[n]=0),t[n]+=1}}this._stats={freq:t,sameLength:e}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...rt().count(0).take(this.column.length).map((t=>this.getSplitted(t).length)))),this._maxLength}_posList=null;get posList(){if(null===this._posList){const t=this.column.getTag(gt.gp.positionNames);this._posList=t?t.split(gt.z1).map((t=>t.trim())):rt().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===gt.Hi.FASTA}isSeparator(){return this.notation===gt.Hi.SEPARATOR||!!this.separator}isHelm(){return this.notation===gt.Hi.HELM}isCustom(){return this.notation===gt.Hi.CUSTOM}isRna(){return this.alphabet===gt.YI.RNA}isDna(){return this.alphabet===gt.YI.DNA}isPeptide(){return this.alphabet===gt.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||t===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return gt.Hi.FASTA;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return gt.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.Hi.HELM;if(this.units.toLowerCase().startsWith(gt.Hi.CUSTOM))return gt.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e,n,i){const r=this.column,o=t.toLowerCase()+"("+r.name+")",s=n??r.dataFrame?.columns.getUnusedName(o)??o,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=t,t===gt.Hi.SEPARATOR){if(!e)throw new Error(`Notation '${gt.Hi.SEPARATOR}' requires separator value.`);l.setTag(gt.gp.separator,e)}l.setTag(a.TAGS.CELL_RENDERER,t===gt.Hi.HELM?"helm":"sequence");const c=r.getTag(gt.gp.aligned);c&&l.setTag(gt.gp.aligned,c);let h=r.getTag(gt.gp.alphabet);h||this.notation!==gt.Hi.HELM||t===gt.Hi.HELM||(h=gt.YI.UN),null!=h&&l.setTag(gt.gp.alphabet,h);let u=r.getTag(gt.gp.alphabetSize);null!=h&&u&&l.setTag(gt.gp.alphabetSize,u);const d=r.getTag(gt.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(gt.gp.alphabetIsMultichar,d),t==gt.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(gt.gp.alphabetSize,u)),l}getNewColumnFromList(t,e){return this.getNewColumn(this.notation,this.separator,t,e)}static unitsStringIsValid(t){return t=t.toLowerCase(),[gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!ki.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",e,new Array(t).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(t){let e=null;if(e=this.notationProvider?this.notationProvider.splitter:null,e)return e;if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return null===this.column.getTag(gt.gp.alphabet)||this.getAlphabetIsMultichar()?gt.J9:kt.tm;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return(0,gt.dh)(this.separator,t);if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.qp;throw new Error(`Unexpected units ${this.units} .`)}split(t){return this.splitter(t)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ue.Z.HAMMING;switch(this.alphabet){case gt.YI.DNA:case gt.YI.RNA:case gt.YI.PT:}return ue.Z.LEVENSHTEIN}getDistanceFunction(){return ue.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(gt.gp.isHelmCompatible))return"true"===this.column.getTag(gt.gp.isHelmCompatible);const t=(await(0,bt.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),e=new Set(t),n=((0,gt.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let t=0;t<i;++t){const i=r[t];if(!(i in n)){n.add(i);const r=this.getSplitted(t);for(let t=0;t<r.length;++t){const n=r.getCanonical(t);if(!e.has(n))return this.column.setTag(gt.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(gt.gp.isHelmCompatible,"true"),!0}toFasta(t){return t===gt.Hi.FASTA}toSeparator(t){return t===gt.Hi.SEPARATOR}toHelm(t){return t===gt.Hi.HELM}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?wt.b9[gt.Hi.FASTA]:wt.b9[gt.Hi.SEPARATOR]),n||(n=this.toFasta(e)?"":this.separator);const r=t.startsWith("RNA"),o=(0,gt.qp)(t),s=[];for(let t=0;t<o.length;++t){let n=o.getOriginal(t);if(r&&(n=n.replace(bn.EK,"$1")),n===wt.b9[gt.Hi.HELM])s.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join(n)}convert(t,e){const n=this.getJoiner({notation:t,separator:e}),i=this.getNewColumn(t,e);return i.init((t=>{const e=this.getSplitted(t);return n(e)})),i}getRegion(t,e,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=t??0,o=e??this.maxLength-1,s=this.getJoiner(),a=o-r+1,l=wt.b9[this.notation];i.init((t=>{const e=this.getSplitted(t),n=new Array(a);for(let t=0;t<a;++t){const i=r+t;n[t]=i<e.length?e.getOriginal(i):l}return s(new kt.Mu(n,l))}));const c=t=>{const e=t.split(",").map((t=>t.trim())),n=new Array(a);for(let t=0;t<a;++t){const i=r+t;n[t]=i<e.length?e[i]:"?"}return n.join(gt.z1)},h=this.column.getTag(gt.gp.positionNames);h&&i.setTag(gt.gp.positionNames,c(h));const u=this.column.getTag(gt.gp.positionLabels);return u&&i.setTag(gt.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(t){const e=t?t.notation:this.notation,n=t?t.separator:this.separator;let i;const r=this;switch(e){case gt.Hi.FASTA:i=function(t){return r.joinToFasta(t,r.isHelm())};break;case gt.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${e}'.`);i=function(t){return Gi(t,n,r.isHelm())};break;case gt.Hi.HELM:{const t=r.alphabet===gt.YI.DNA||r.alphabet===gt.YI.RNA,e=r.getHelmWrappers();i=function(n){return Fi(n,e,t)};break}default:throw new Error(`Unexpected notation '${e}'.`)}return i}getConverter(t,e=void 0){if(t===gt.Hi.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${gt.Hi.SEPARATOR}'.`);const n=this;if(t===gt.Hi.FASTA)return function(t){return n.convertToFasta(t)};if(t===gt.Hi.HELM)return function(t){return n.convertToHelm(t)};if(t===gt.Hi.SEPARATOR)return function(t){return n.convertToSeparator(t,e)};throw new Error}static forColumn(t,e){let n=t.temp[Ut.seqHandler];return n&&n.columnVersion===t.version||(n=t.temp[Ut.seqHandler]=new ki(t,e)),n}joinToFasta(t,e){const n=new Array(t.length);for(let i=0;i<t.length;++i){const r=t.getOriginal(i);let o=t.getOriginal(i);e&&(o=o.replace(bn.EK,"$1")),r===wt._S?o=wt.b9[gt.Hi.FASTA]:r===bn.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(t){const e=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(t):e(t);return this.joinToFasta(n,this.isHelm())}convertToSeparator(t,e){return Gi(this.isHelm()?this.splitterAsHelmNucl(t):this.splitter(t),e,this.isHelm())}convertToHelm(t){if(this.notation==gt.Hi.HELM)return t;const e=this.getHelmWrappers(),n=t.startsWith("DNA")||t.startsWith("RNA");return Fi(this.splitter(t),e,n)}splitterAsHelmNucl(t){const e=this.splitter(t),n=new Array(e.length),i=t.startsWith("DNA"),r=t.startsWith("RNA");for(let t=0;t<e.length;++t){let o=e.getOriginal(t);(i||r)&&(o=o.replace(bn.EK,"$1"),o=o===bn.q7?null:o),n[t]=o||null}return new kt.Mu(n.filter((t=>!!t)),wt.b9[gt.Hi.HELM])}getRendererBack(t,e){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(t,e)),i}}function Gi(t,e,n){const i=new Array(t.length);for(let e=0;e<t.length;++e){const r=t.getCanonical(e);let o=t.getOriginal(e);n&&(o=o.replace(bn.EK,"$1")),r===wt._S?o=wt.b9[gt.Hi.SEPARATOR]:r===bn.q7&&(o=""),i[e]=o}return i.join(e)}function Fi(t,e,n){const[i,r,o,s]=e,a=new Array(t.length);for(let e=0;e<t.length;++e){const i=t.getCanonical(e);let s=t.getOriginal(e);i===wt._S?s=wt.b9[gt.Hi.HELM]:(n&&(s=s.replace(bn.EK,"$1")),s=1===s.length?`${r}${s}${o}`:`${r}[${s}]${o}`),a[e]=s}return`${i}${a.join(".")}${s}`}class Hi{libHelper;rdKitModule;constructor(t,e){this.libHelper=t,this.rdKitModule=e}getSeqHandler(t){return ki.forColumn(t,this)}getSeqMonomers(t){const e=this.getSeqHandler(t);return Object.keys(e.stats.freq)}async getHelmToMolfileConverter(t){const e=await(0,ke.b2)();return new Oi(e,this.rdKitModule,t)}helmToAtomicLevelSingle(t,e,n,i=!0){if(!t)return gi.vF.createEmpty();const r=e.convertToMolfileV3K([t])[0];if(!r||!r.molfile)return gi.vF.createEmpty();let o=null;try{let t=r.molfile;if(i){if(o=this.rdKitModule.get_mol(t),!o)return gi.vF.createEmpty();o.set_new_coords(),o.normalize_depiction(1),o.straighten_depiction(!0),t=o.get_v3Kmolblock()}return n&&(t=e.molV3KtoMolV3KOCL(t)),new gi.vF(t,r.monomers)}catch(t){const[e,n]=(0,Ct.AP)(t);return Di.logger.error(e,void 0,n),gi.vF.createEmpty()}finally{o?.delete()}}async helmToAtomicLevel(t,e,n,i){const r=i??this.libHelper.getMonomerLib(),s=t.dataFrame,l=(0,yi.qj)(s,t.name),c=await this.getHelmToMolfileConverter(r),h=t.toList(),u=new Array(t.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<t.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,e&&!p,!d).molfile;if(d){const e=await d.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n])}if(e&&p){const e=await p.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n]);else o.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",t.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.FASTA)throw new Error(`The column of notation '${gt.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);t.column.meta.units=gt.Hi.FASTA,ki.setTags(t)}setUnitsToSeparatorColumn(t,e){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.SEPARATOR)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must have the separator tag.`);t.column.meta.units=gt.Hi.SEPARATOR,t.column.setTag(gt.gp.separator,e),ki.setTags(t)}setUnitsToHelmColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${gt.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);t.column.meta.units=gt.Hi.HELM,ki.setTags(t)}}class Bi{constructor(t){this.canvas=null,this.ctx=null,this.config={x:t.x||0,y:t.y||0,width:t.width||0,height:t.height||0,windowStartPosition:t.windowStartPosition||1,positionWidth:t.positionWidth||15,totalPositions:t.totalPositions||5e3,headerHeight:t.headerHeight||50,sliderHeight:t.sliderHeight||8,currentPosition:t.currentPosition||1,cellBackground:void 0===t.cellBackground||t.cellBackground,sliderColor:t.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:t.onPositionChange||((t,e)=>{}),...t},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.init()}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("canvas not found.");const t=this.canvas.getContext("2d");t?(this.ctx=t,this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))):console.error("Failed to get 2D context from canvas")}get isValid(){return!!this.canvas&&!!this.ctx&&this.config.height>=this.config.headerHeight}draw(t,e,n,i,r,o,s){if(this.config.x==t&&this.config.y==e&&this.config.width==n&&this.config.height==i&&this.config.currentPosition==r&&this.config.windowStartPosition==o||Object.assign(this.config,{x:t,y:e,width:n,height:i,currentPosition:r,windowStartPosition:o}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(t,e,n,i),this.ctx.translate(t,e),this.ctx.rect(0,0,n,i),this.ctx.clip();const a=n,l=i,c=this.config.headerHeight-this.config.sliderHeight;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(0,c,a,this.config.sliderHeight);const h=Math.floor(this.config.width/this.config.positionWidth),u=Math.max(1,this.config.windowStartPosition),d=this.config.totalPositions-h,p=d<=0?0:u/this.config.totalPositions*(a-this.sliderWidth),m=d<=0?a:this.sliderWidth;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(p,c,m,this.config.sliderHeight),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const t=(this.config.currentPosition-1)/(this.config.totalPositions-1),e=Math.round(t*a);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e-1,c-2,3,this.config.sliderHeight+4)}for(let t=0;t<h;t++){const e=u+t;if(e>this.config.totalPositions)break;const n=t*this.config.positionWidth,i=this.config.positionWidth,r=n+i/2;this.config.cellBackground&&(this.ctx.fillStyle=t%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(n,5,i,Math.min(this.config.headerHeight-5,l-5)-this.config.sliderHeight),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(n,5),this.ctx.lineTo(n,Math.min(this.config.headerHeight,l)-this.config.sliderHeight),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(r,10,1,0,2*Math.PI),this.ctx.fill(),(e===this.config.currentPosition||(1===e||e%10==0)&&Math.abs(e-this.config.currentPosition)>1)&&(this.ctx.fillStyle="#333333",this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e.toString(),r,20)),e===this.config.currentPosition&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(n,0,i,c))}this.ctx.restore(),s.preventDefault(),this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(t){const e=this.canvas.getBoundingClientRect();return{x:t.clientX-e.left-this.config.x,y:t.clientY-e.top-this.config.y}}isInHeaderArea(t){const{x:e,y:n}=this.getCoords(t);return e>=0&&e<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(t){this.config.positionWidth=t}isInSliderArea(t){const{y:e}=this.getCoords(t),n=this.config.headerHeight-this.config.sliderHeight;return e>n&&e<n+this.config.sliderHeight}get sliderWidth(){const t=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(t,20)}isInSliderDraggableArea(t){const{x:e,y:n}=this.getCoords(t),i=this.config.headerHeight-this.config.sliderHeight,r=(this.config.windowStartPosition-1)*((this.config.width-this.sliderWidth)/this.config.totalPositions),o=r+this.sliderWidth;return n>i&&n<i+this.config.sliderHeight&&e>=r&&e<o}handleMouseDown(t){if(!this.isValid)return;const{x:e}=this.getCoords(t);this.isInSliderDraggableArea(t)&&(this.state.isDragging=!0,this.state.dragStartX=e,this.handleSliderDrag(e),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation())}handleMouseWheel(t){if(this.isValid&&this.isInHeaderArea(t)){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e=t.shiftKey?Math.sign(t.deltaY):Math.sign(t.deltaX||t.deltaY),n=t.shiftKey?3:1,i=this.config.windowStartPosition+e*n,r=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-r+1;this.config.windowStartPosition=Math.max(1,Math.min(o,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(t){if(!this.state.isDragging||!this.isValid)return;const e=this.canvas.getBoundingClientRect(),n=t.clientX-e.left-this.config.x;this.handleSliderDrag(n),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}handleKeyDown(t){if(this.isValid&&!(this.config.currentPosition<1)){if("ArrowLeft"===t.key||"ArrowRight"===t.key){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e="ArrowLeft"===t.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+e,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition;(n<r||n>r+i-1)&&(this.config.windowStartPosition=e<0?n:Math.max(1,n-i+1))}else{if("Escape"!==t.key)return;this.config.currentPosition=-2,t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(t){if(!this.isValid)return;const e=this.sliderWidth,n=this.config.width-e,i=Math.max(0,Math.min(this.config.width,t)),r=n/this.config.totalPositions,o=Math.floor(this.config.width/this.config.positionWidth);this.config.windowStartPosition=Math.max(1,Math.min(Math.round((i-e/2)/r),this.config.totalPositions-o+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(t){this.config.headerHeight=t}handleClick(t){if(!this.isValid)return;const{x:e,y:n}=this.getCoords(t);if(n<this.config.headerHeight-this.config.sliderHeight&&n>=0){const t=this.config.positionWidth,n=Math.round(e/t-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(t){Object.assign(this.config,t),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(t){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}const Di=new ai;async function Vi(){return await pn.getInstance()}class ji{_palette;constructor(t){this._palette=t}get(t){return this._palette[t]}}let Ui=null;async function Wi(){null===Ui&&(Ui=async function(){const t="Bio: _package.initBio()";Di.logger.debug(`${t}, start`);const e=window.performance.now(),n=await(0,Pt.j)(),i=await Di.getProperties(),r=new si(i);Di.properties=r;const s=await pn.getInstance(),l=await(0,Nt.ub)();l.explicit&&(l.explicit=[],await(0,Nt.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),h=s.getMonomerSets(),u=window.performance.now();Di.logger.debug(`${t}, loading ET: ${u-e} ms`);const d=new Hi(s,n);Di.completeInit(d,c,h,n),Di.logger.debug(`${t}, end`),function(){const t=t=>{setTimeout((()=>{if(t.isDetached)return;const e=t.dataFrame;if(!e)return;const n=e.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const e of n){const n=Di.seqHelper.getSeqHandler(e);if(!n)continue;if(n.isHelm()||n.alphabet===gt.YI.UN)continue;const i=t.col(e.name);if(!i)continue;let r=!1;const o=(t,e)=>Number.isNaN(t)?e:t,s=()=>o(Math.max(Number.parseInt(e.getTag(gt.gp.positionShift)??"0"),0),0)+1,l=()=>o(Number.parseInt(e.getTag(gt.gp.selectedPosition)??"-2"),-2),c=()=>Ot.Jy.getFontSettings(e).fontWidth;let h=0;for(let t=0;t<Math.min(30,e.categories.length);t++){const t=Math.floor(Math.random()*e.categories.length-1),i=n.splitter(e.categories[t]);i&&(h=Math.max(h,i.length))}if(h<50)continue;const u=40,d=new Bi({canvas:t.overlay,headerHeight:u,totalPositions:h+1,onPositionChange:(n,i)=>{setTimeout((()=>{const o=s(),c=l();if(o!==i.start&&e.setTag(gt.gp.positionShift,(i.start-1).toString()),n>=0&&c!==n&&(e.setTag(gt.gp.selectedPosition,n.toString()),!r&&t.tableView)){r=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))}});t.props.colHeaderHeight=65,setTimeout((()=>{t.isDetached||(i.width=400)}),300),t.sub(t.onCellRender.subscribe((n=>{const r=n.cell;if(!r||!r.isColHeader||r?.gridColumn?.name!==i?.name)return;const o=n.bounds;if(!o||o.height<=50)return;const a=o.height-u;if(a>20){d.headerHeight=o.height-20;const n=t.overlay.getContext("2d");if(!n)return;n.save(),n.rect(o.x,o.y,o.width,20),n.clip(),n.font=t.props.colHeaderFont??"bold 13px Roboto, Roboto Local",n.fillStyle="#4a4a49",n.textAlign="center",n.textBaseline="middle";const i=o.x+o.width/2,r=o.y+10;n.fillText(e.name??"",i,r),n.restore()}else d.headerHeight=Math.max(u,o.height);const h=Math.max(0,a??0)>20?20:0,p=c();d.positionWidth=p+8;const m=s();d.draw(o.x,o.y+h,o.width,o.height-h,l(),m,n)})))}}),1e3)},e=(o.events.onViewerAdded.subscribe((e=>{if(!(e.args&&e.args.viewer instanceof a.Grid))return;const n=e.args.viewer;t(n)})),o.shell.tableViews);for(const n of e){const e=n?.grid;e&&t(e)}}()}()),await Ui}function qi(t){const e=new ci(t,Di.seqHelper);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();o.shell.error(e)})),e}function zi(){return Di.monomerLib}function Yi(t){return Di.seqHelper.getSeqHandler(t)}function Ki(t){const e="getRegionTopMenu",n=a.Func.find({package:Di.name,name:e});if(1!==n.length)throw new Error(`Package '${Di.name}' func '${e}' not found`);const i=n[0].prepare({table:t.dataFrame,sequence:t});return new pi(i,Di.seqHelper).widget()}async function Zi(t){return async function(){const t=s.label("Manage monomer libraries");return fn()(t).addClass("d4-link-action"),t.onclick=async()=>await Vn(),new a.Widget(t)}()}function Xi(t){try{new pi(t,Di.seqHelper).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;o.shell.error(`Get region editor error: ${e}`),Di.logger.error(e,void 0,n)}}function Ji(t){const e=new ei;s.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Qi(t){const e=new $({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function tr(t){const e=new St({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function er(){return new Yt}function nr(){return new Yt}function ir(){return new Yt}function rr(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===a.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);let n=Di.properties?Di.properties.maxMonomerLength:4;if(Rt.gp.maxMonomerLength in t.tags){const e=parseInt(t.getTag(Rt.gp.maxMonomerLength));n=isNaN(e)?n:e}if(".mm.cellRenderer.maxMonomerLength"in t.temp){const e=parseInt(t.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(e)?n:e}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(0==e)setTimeout((()=>{i.value=null}),0);else{const n=e??"",i=null==n?"":n.toString();t.temp[".mm.cellRenderer.maxMonomerLength"]=i,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let r=Di.properties?Di.properties.fontSize:12;".mm.cellRenderer.fontSize"in t.temp&&t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(r=t.temp[".mm.cellRenderer.fontSize"]);const o=s.input.int("Font Size",{value:r,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(e&&e>0){const n=e??12;t.temp[".mm.cellRenderer.fontSize"]=n,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:t.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==t?.temp["color-code"]||t.temp["color-code"],onValueChanged:e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],onValueChanged:e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),d=s.inputs([o,i,l,h,c,u]);return new a.Widget(d)}(t)}function or(t){return(0,li.j)(t,Di.monomerLib,Di.seqHelper)}function sr(){return new Zt}function ar(t,e,n,i,r){const o=new he.$(i,r,n,e);return"Local alignment"==t?o.smithWaterman():o.needlemanWunsch()}function lr(){return new re.oP}function cr(){return new ce}function hr(t,e,n,i){return hi(t,e??null,n??null,i??null)}async function ur(t,e,n,i,r){const s=hi(e,n??null,i??null,r??null);e.dataFrame.columns.add(s),await o.data.detectSemanticTypes(e.dataFrame)}async function dr(t,e,n,i,r,h,u,d,p){if(!(0,Xn.V)(e,"Activity Cliffs"))return;const m=It(t),f={units:e.meta.units,aligned:e.getTag(gt.gp.aligned),separator:e.getTag(gt.gp.separator),alphabet:e.getTag(gt.gp.alphabet)},g=h,y=e,b=async()=>await mt(t,y,m,"Activity cliffs",n,i,g,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,u,me,fe,ve,void 0,p),v=r===c.c.UMAP?2e5:2e4,w=r===c.c.UMAP?5e3:2e3;if(t.rowCount>v)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((e,n)=>{t.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((t=>e(t))).catch((t=>n(t)))})).onCancel((()=>{e(void 0)})).show():b().then((t=>e(t))).catch((t=>n(t)))})).catch((t=>{const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t})).finally((()=>{C.close()}))}async function pr(t,e,n=1,i=.6,r="Morgan"){if(t.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:t.toList(),options:{}};const{seqList:o,options:s}=await de(t,e,r);return{entries:o,options:{...s,gapOpen:n,gapExtend:i}}}async function mr(t,e){t.version!==t.temp["last-invalidated-version"]&&await(0,pe.BQ)(t,Di.seqHelper,!1);const n=t.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let t=0;t<i.length;t++){if(i.isNone(t)||!i.get(t))continue;const e=i.get(t);r[t]=V.A.fromUint32Array(e.length,new Uint32Array(e.getBuffer().buffer))}return{entries:r,options:{}}}async function fr(t,e,i,r,c,h,u,d,p){const m=o.shell.tv.dataFrame==t?o.shell.tv:void 0;if((0,Xn.V)(e,"Sequence Space"))return h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(t,e,i,r,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(e.length!==r.length||e.length!==h.length||e.length!==c.length||e.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??o.shell.tableView(t.name)??o.shell.addTableView(t):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=It(t);function x(n,r,o){let c=null,h=null;t.columns.names().includes(S[0])?(c=t.columns.byName(S[0]),h=t.columns.byName(S[1])):(c=t.columns.add(a.Column.float(S[0],t.rowCount)),h=t.columns.add(a.Column.float(S[1],t.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Tt(e,i)}))),f[l.YP]&&(A?.root&&s.setUpdateIndicator(A.root,!1),c.init((t=>o[0]?o[0][t]:void 0)),h.init((t=>o[1]?o[1][t]:void 0)));const u=n/r*100;C.update(u,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function E(){t.columns.add(a.Column.float(S[0],t.rowCount)),t.columns.add(a.Column.float(S[1],t.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Tt(e,i)}),s.setUpdateIndicator(A.root,!0));const p=o.events.onViewerClosed.subscribe((t=>{const e=t.args.viewer;e?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&e?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(q.S,{}),p.unsubscribe(),n?.(),C.close())})),g=new Promise((async(o,s)=>{try{n=o;const s=[];let a=r,d=c,p=u;if(b&&e.every((t=>t.isNumerical))){const n=e.map((t=>t.toList())),i=new Array(t.rowCount).fill(0).map(((t,n)=>new Float32Array(e.length)));for(let r=0;r<e.length;++r)for(let e=0;e<t.rowCount;++e)i[e][r]=n[r][e];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let t=0;t<h.length;++t){const n=h[t];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:e[t],[o]:r[t],...m.preprocessingFuncArgs[t]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=e[t].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}o(await Y(s.map((t=>t.entries)),i,a,d,u,m,f[l.vb]?void 0:x))}catch(t){s(t)}})),y=await g;return C.close(),p.unsubscribe(),y}const M=await E();if(p&&M){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(t,e,i,r){return _t(this,void 0,void 0,(function*(){return new Promise((function(o,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:t,embedY:e,minPts:r,epsilon:i}),a.onmessage=({data:{error:t,clusters:e}})=>{a.terminate(),t?s(t):o(e)}}))}))}(M[0],M[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),T=t.columns.getUnusedName("Cluster (DBSCAN)");t.columns.addNewString(T).init((t=>I[t].toString())),A&&(A.props.colorColumnName=T)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{_.close()}}if(M){const N=t.columns.byName(S[0]),P=t.columns.byName(S[1]);if(N.init((t=>M[0][t])),P.init((t=>M[1][t])),g)try{const $=g.inputs[0].name,R=g.inputs[1].name;await g.prepare({[$]:N,[R]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return s.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&s.setUpdateIndicator(A.root,!1)}};return new Promise((async(e,n)=>{try{if(f.fastRowCount&&t.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const t=await C();e(t)}catch(t){n(t)}})).onCancel((()=>e(void 0))).show();else{const t=await C();e(t)}}catch(t){n(t)}}))}(t,[e],i,[r],[1],[h],"MANHATTAN",c,d??!1,{...u,preprocessingFuncArgs:[u.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:u?.[l.vb],tableView:m})}async function gr(t,e,n,i=!1){const r=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ui;const r=e.temp[".mm.cellRenderer.overriddenLibrary"]??Di.monomerLib,o=Di.seqHelper,s=Di.rdKitModule;await(0,mi.V)(t,e,n,i,r,o,s)}finally{r.close()}}async function yr(t){if(!t?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const e=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!e)throw new Error("To Atomic level Function not found");e.prepare({table:t.dataFrame,seqCol:t}).edit()}async function br(t){return async function(t){const e=s.divText(""),n=a.Widget.fromRoot(e);try{if(!t||!t.value)return e.innerText="No sequence provided",n;if(!(t.cell&&t.cell.dart&&t.cell.dataFrame&&t.cell.column))return e.innerText="Atomic level conversion requeires a sequence column",n;if(![gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].includes(t.cell.column.meta.units?.toLowerCase()??""))return e.innerText="Unsupported sequence notation. please use Bio | Polytool | Convert",n;const i=(await lo()).getSeqHandler(t.cell.column);if(!i)return e.innerText="No sequence handler found",n;if((i.getSplitted(t.cell.rowIndex,50)?.length??100)>40)return e.innerText="Maximum number of monomers is 40",n;const r=a.Column.fromStrings("singleVal",[t.value]),l=a.DataFrame.fromColumns([r]);if(Object.entries(t.cell.column.tags).forEach((([t,e])=>{r.setTag(t,e)})),await gr(l,r,t.cell.column.meta.units===gt.Hi.HELM,!1),l.columns.length<2)return e.innerText="No structure generated",n;const c=l.columns.byIndex(1),h=c.get(0);if(!h)return e.innerText="No structure generated",n;c.semType=a.SEMTYPE.MOLECULE;const u=a.SemanticValue.fromTableCell(l.cell(0,c.name)),d=s.panels.infoPanel(u);let p=null;d&&(p=a.Widget.fromRoot(d.root));const m=o.chem.drawMolecule(h,300,300,!1);return m.style.cursor="pointer",s.tooltip.bind(m,"Click to expand"),m.onclick=()=>{const t=window.innerWidth-200,e=window.innerHeight-200,n=o.chem.drawMolecule(h,t,e,!1);s.dialog({title:"Molecule"}).add(n).showModal(!0)},p&&p.root.prepend(m),p??a.Widget.fromRoot(m)}catch(t){Di.logger.error(t)}return e.innerText="No Structure generated",n}(t)}function vr(){(0,Qn.D)({},Di.seqHelper).catch((t=>{const[e,n]=(0,Ct.AP)(t);if(t instanceof Jn.Ap)return o.shell.warning(t.element),void Di.logger.warning(e);o.shell.error(e),Di.logger.error(e,void 0,n)}))}async function wr(t=null,e=null,n){return(0,Qn.D)({col:t,clustersCol:e,...n},Di.seqHelper)}async function Cr(){const t=o.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==a.SEMTYPE.MACROMOLECULE&&(Di.seqHelper.getSeqHandler(t),!0))),n=async e=>{if(!(0,Xn.V)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>Di.seqHelper.getSeqHandler(t).isMsa())),r=s.input.choice("Column",{value:i?i.name:t[0],items:t});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await n(t)})).show()}else i=e[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Ar(t){return new yt.m(t).importFasta()}function Sr(t){return console.log(t),[]}function xr(){const t=(0,$t.me)()[0];(0,_e.C)(t,Di.seqHelper)}function Er(t){(0,_e.C)(t,Di.seqHelper)}function Mr(){return new ri}async function _r(t){const e=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const e=await o.dapi.files.readAsText(t+s.fullPath),n=a.DataFrame.fromCsv(e);for(const t of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:t})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:t.name,message:`units: ${t.meta.units}`})}catch(t){r.push({file:s.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${t}`,s}async function Ir(t,e){return await async function(t,e){if(await(0,te.cb)(10),!(0,Xn.V)(e,"Sequence space"))return t;const n=Di.seqHelper,i=(0,vt.R)(e,n);i.name="splitToMonomers";const r=e.dataFrame;for(const t of i.columns)t.semType=jt.uF.MONOMER,t.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=t=>{s.lastIndex=0;const e=t.match(s);return e?`${e[1]} (${parseInt(e[2]??"0")+1})`:t};for(let t=0;t<i.columns.length;t++){const n=i.columns.byIndex(t);n.semType=jt.uF.MONOMER,n.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const o=100;let s=0;for(;r.columns.byName(n.name)&&s<o;)n.name=l(n.name),s++;r.columns.add(n)}await o.data.detectSemanticTypes(r);for(let t=0;t<i.columns.length;t++){const e=i.columns.byIndex(t);e.setTag(a.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return r}(t,e)}function Tr(t){return Di.seqHelper.getSeqMonomers(t)}function Lr(){return new Se(Di.seqHelper)}function Nr(){const t=o.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Pr(){return new Ee(Di.seqHelper)}function $r(){const t=o.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Rr(t){const e=(0,$t.me)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new pe.a7(e,Di.seqHelper)}function Or(t){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),o.shell.tv.grid.scrollToCell(t,0)}async function kr(t,e,n){const i=Di.seqHelper;return fi(t,e,n,ft.IDENTITY,i)}async function Gr(t,e,n){const i=Di.seqHelper;return fi(t,e,n,ft.SIMILARITY,i)}async function Fr(){Vn()}async function Hr(){await jn()}async function Br(){const t=await _n.getInstance();await t.getViewRoot()}async function Dr(){return await jn(!1)}async function Vr(t,e){(await(await pn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((e=>{const n=e.endsWith(".json")?e.substring(0,e.length-5):e;t.item(n).onSelected.subscribe((async()=>{const t=await _n.getInstance();await t.getViewRoot(e,!0),t.resetCurrentRowFollowing()}))}))}function jr(){(0,Ie.TE)()}function Ur(){return new Te._i(Di.seqHelper,Di.logger)}function Wr(){return new Te._i(Di.seqHelper,Di.logger)}async function qr(){const t=a.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new ti(t,"webLogoLargeApp"),n=await Di.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function zr(){const t=a.TaskBarProgressIndicator.create("WebLogo ...");try{const t=new URLSearchParams(window.location.search),e=new ti(t,"webLogoAggApp"),n=await Di.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function Yr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new di(t,"getRegionApp");await e.init()}finally{t.close()}}async function Kr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await Di.files.readCsv("samples/HELM_empty_vals.csv"),n=new di(t,"getRegionHelmApp");await n.init({df:e,colName:"HELM"})}finally{t.close()}}function Zr(){const t=a.DataFrame.fromColumns((0,Lt.dW)());o.shell.addTableView(t)}function Xr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(Di.seqHelper,gt.Hi.FASTA)]);o.shell.addTableView(t)}function Jr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(Di.seqHelper,gt.Hi.HELM)]);o.shell.addTableView(t)}function Qr(t,e){!function(t,e,n){const i=n.getSeqHandler(t.column),r=Object.values(gt.Hi).filter((t=>t!==i.units));e.group("Copy").items(r,(e=>{const i=t.column,r=t.rowIndex,s=n.getSeqHandler(i),a=e===gt.Hi.SEPARATOR?Di.properties.defaultSeparator:void 0,l=s.getJoiner({notation:e,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${e}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e,Di.seqHelper)}async function to(){await async function(){const t=await Di.files.readCsv("samples/peptides-non-natural.csv");t.name="Similarity and Diversity Demo",t.col("activity").setTag("format","3 significant digits"),t.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const e=o.shell.addTableView(t);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t);const n=e.addViewer("Sequence Similarity Search",{limit:20}),i=e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,$t.Kd)(e.grid,"sequence",500,30);const r=e.addViewer("Sequence Diversity Search",{limit:20});e.dockManager.dock(r,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function eo(){await async function(){const t=await o.functions.eval("Bio:SeqSpaceDemo"),e=await o.dapi.projects.find(t.id);await e.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function no(){await async function(){const t=await Di.files.readCsv("tests/helm_cyclic_cliffs.csv");t.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(t),await t.meta.detectSemanticTypes();const e=o.shell.addTableView(t);s.setUpdateIndicator(e.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await dr(t,t.getCol("Sequence"),t.getCol("Activity"),96,c.c.UMAP,ue.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),fn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),e.grid.props.rowHeight=180,e.grid.col("sequence")&&(e.grid.col("sequence").width=300),e.grid.col("structure")&&(e.grid.col("structure").width=300);const r=Array.from(e.viewers).find((t=>t!==e.grid&&t.type===a.VIEWER.GRID));r&&(r.props.rowHeight=40,r.col("seq_diff").width=600,e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(t){!function(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;o.shell.error(e),Di.logger.error(t.message,void 0,n)}(t)}finally{s.setUpdateIndicator(e.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function io(){await async function(){const t=await Di.files.readCsv("samples/HELM_BI_CYCLIC.csv");t.name="To Atomic Level",await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t);const e=o.shell.addTableView(t),n=t.col("HELM");await gr(t,n,!0,!1),(0,$t.Kd)(e.grid,"molfile(HELM)",500,300,!0),(0,$t.Kd)(e.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function ro(t){const e=(0,bt.uX)(t),n=JSON.stringify(e);a.Utils.download(`${t.name}.json`,n)}async function oo(t,e){if(!t.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[t]),i=a.DataFrame.fromColumns([n]),r=await o.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=(await Vi()).getMonomerLib(),l=Di.seqHelper,c=await(0,Pt.j)(),h=(await(0,mi.V)(i,n,e,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(t){const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t}}async function so(t,e){if(!t.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[t]),i=a.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await fi(i,n,e,ft.IDENTITY,Di.seqHelper)).get(0)}catch(t){const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t}}async function ao(t,e,n){const i=await t.readAsString();await async function(t,e,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(t),u=e?h.getCol(e):h.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,te.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,e,n)}async function lo(){return await Wi(),Di.seqHelper}function co(t,e,n){return async function(t,e,n=!0,i){const r=Di.seqHelper,o=(await r.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(e,n,Di.rdKitModule,i);return o.semType=a.SEMTYPE.MOLECULE,o}(0,e,n,Di.monomerLib)}function ho(){return Di.logger.debug("Bio:test1() function"),{value:"value1"}}},6625:(t,e,n)=>{"use strict";n.d(e,{$:()=>o});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{seq1;seq2;score;constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class o{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",o="";const s=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)o+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=o+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=o+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:o+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:o+i);const r=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[r][e].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>t&&(t=this.dpGrid[i][r].value,e=i,n=r);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.setMethod(i),this.setSequences(t,e),this.setGap(n)}}},8115:(t,e,n)=>{"use strict";n.d(e,{BQ:()=>m,a7:()=>u,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(8070),a=n(2003),l=n(1407),c=n(4870);const h="substr_helm";class u{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(t,e){this.seqHelper=e,this.col=t[0],this.createUI()}editHelmLinkAction(){(0,c.Ku)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===a.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,c.Ku)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:t,value:this.col,onValueChanged:t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()},filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const e=o.DataFrame.create(1);e.columns.addNewString(h).init((t=>"")),e.col(h).semType=this.col.semType,e.col(h).meta.units=a.Hi.HELM,this.grid=e.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,n=this.units===a.Hi.HELM?e.get(h,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),t=this.units===a.Hi.HELM?await p(n,this.col,this.seqHelper):d(n,this.col),this.col.dataFrame.filter.and(t)})).show()}}function d(t,e,n){const i=n?function(t,e){const n=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,r=t.charAt(t.length-1)===e,o=t.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(t,n):t,r=o.BitSet.create(e.length);for(let n=0;n<e.length;n++){const o=e.get(n);(o.match(i)||o===t)&&r.set(n,!0,!1)}return r}async function p(t,e,n){e.version!==e.temp["last-invalidated-version"]&&await m(e,n,!0);const r=o.Column.string("helm",1).init((e=>t));r.semType=o.SEMTYPE.MACROMOLECULE,r.meta.units=a.Hi.HELM;const s=await(0,l.R)(r,n,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function m(t,e,n){const i=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);try{await(0,s.cb)(10);const i=new Map,r=await(0,l.R)(t,e,n,i);t.temp["monomeric-mols"]=r,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version}finally{i.close()}}},966:(t,e,n)=>{"use strict";n.d(e,{V:()=>s,l:()=>a});var i=n(4328),r=n(6082),o=n(6766);function s(t,e,n=[],r=[],s=!0){const l=o._package.seqHelper,[c,h]=a(t,e,l,n,r);return s&&!c&&i.shell.warning(h),c}function a(t,e,n,o=[],s=[]){let a=!0,l="";if(t.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(t),r=i.notation;if(o.length>0&&!o.some((t=>r.toUpperCase()==t.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==o.length?"any notation":`notation${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const t=i.alphabet;s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(t,e,n)=>{"use strict";n.d(e,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(8152);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(r||(r={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(t){t.CELL_CHANGING="isCellChanging"}(s||(s={})),function(t){t.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(t,e,n)=>{"use strict";n.d(e,{C:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(t,e){let n=t??o.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=e.getSeqHandler(n),u=s.notation;const d=r.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:n,filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:t=>(n=t,s=e.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((t=>t!==u)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(r.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((t=>t!==u));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const t=v.value,i=t===l.Hi.SEPARATOR?y.value:void 0;await async function(t,e,n,i){const r=e.getSeqHandler(t).convert(n,i);t.dataFrame.columns.add(r);const s=await o.functions.call("Bio:detectMacromolecule",{col:r});return s&&(r.semType=s),await o.data.detectSemanticTypes(t.dataFrame),r}(n,e,t,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((t=>{h.forEach((t=>{t.unsubscribe()})),h=[],c=null}))))}},536:(t,e,n)=>{"use strict";n.d(e,{Z:()=>r});var i=n(6956);class r{constructor(t){const e=t.split(i.xe).filter((t=>t));e.forEach((t=>this.validateConnectionItem(t))),this.connectionItems=e}connectionItems;validateConnectionItem(t){const e="(PEPTIDE|RNA)",n=new RegExp(`${e}[0-9]+,${e}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!t.match(n))throw new Error(`Cannot parse connection item from ${t}`)}getConnectionData(){const t=[];return this.connectionItems.forEach((e=>{const n=[],i=e.split(",");i[2].split("-").forEach(((t,e)=>{const r=i[e],o=t.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),t.push(n)})),t}}},6956:(t,e,n)=>{"use strict";n.d(e,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},9099:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(536),r=n(6956),o=n(9034);class s{helmString;constructor(t){this.helmString=t;const e=this.helmString.split(r.pk),n=e[0].split(r.xe);this.simplePolymers=n.map((t=>new o.d(t))),this.connectionList=new i.Z(e[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const t=this.simplePolymers.map((t=>t.monomers.length)).reduce(((t,e)=>t+e),0),e=Array.from({length:t},(()=>[]));return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e[n].push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(t){return this.getSimplePolymerByMonomerIdx(t).polymerType}getSimplePolymerByMonomerIdx(t){const e=this.getMonomerIdxShifts(),n=Object.values(e).sort(((t,e)=>t-e)).find((e=>t>=e));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${t}`);const i=Object.keys(e).find((t=>e[t]===n));return this.simplePolymers.find((t=>t.id===i))}shiftBondMonomerIds(t,e){e.forEach((e=>{e.forEach((e=>{e.monomerIdx+=t}))}))}getMonomerIdxShifts(){const t={};let e=0;return this.simplePolymers.forEach((n=>{t[n.id]=e,e+=n.monomers.length})),t}getBondData(){const t=this.getMonomerIdxShifts(),e=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=t[n.id];this.shiftBondMonomerIds(r,i),e.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((e=>{const n=t[e.polymerId],r=e.bond;r.monomerIdx+=n,i.push(r)})),e.push(i)})),e}}},9034:(t,e,n)=>{"use strict";n.d(e,{d:()=>r});var i=n(8438);class r{simplePolymer;isNucleotideSequence=!1;constructor(t){this.simplePolymer=t,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:e,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=e,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const t=new RegExp("(PEPTIDE|RNA)[0-9]+{"),e=this.simplePolymer.match(t);if(!e)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return e[1]}getIdx(){const t=new RegExp(`${this.polymerType}([0-9]+){`),e=this.simplePolymer.match(t);if(!e)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(e[1])}getMonomerSymbolsAndTypes(){const t=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),e=this.simplePolymer.replace(t,"").split("."),n=[],r=[];return e.forEach((t=>{if(this.isNucleotideSequence){const e=t.split(/\(|\)/).filter((t=>!!t)).map((t=>(0,i.D)(t)));n.push(...e),e.forEach(((t,e)=>r.push(e%3==1?"Branch":"Backbone")))}else n.push((0,i.D)(t)),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const t=[],e=this.monomerTypes.map(((t,e)=>{if("Backbone"===t)return e})).filter((t=>void 0!==t)),n=this.monomerTypes.map(((t,e)=>{if("Branch"===t)return e})).filter((t=>void 0!==t));for(let n=0;n<e.length-1;n++){const i=e[n],r=e[n+1];t.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let e=0;e<n.length;e++){const i=n[e],r=i-1;t.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return t}}},8604:(t,e,n)=>{"use strict";n.d(e,{Es:()=>r,G3:()=>s,gt:()=>o,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",r="System:AppData/Bio/monomer-sets/",o="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(t,e,n)=>{"use strict";n.d(e,{D:()=>_});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),h=n(966),u=n(4139),d=n(5072),p=n.n(d),m=n(7825),f=n.n(m),g=n(7659),y=n.n(g),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=C(),p()(x.A,E),x.A&&x.A.locals&&x.A.locals;var M=n(6766);async function _(t,e){return new Promise((async(n,a)=>{t.clustersCol??=null,t.pepsea??={},t.pepsea.method??=u.HX.pepsea.method,t.pepsea.gapOpen??=u.HX.pepsea.gapOpen,t.pepsea.gapExtend??=u.HX.pepsea.gapExtend;const h=t.col?.dataFrame??i.shell.t,d=t.col??h.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==d){const t="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(t),void a(new l.Ap(o.divText(t)))}const p=o.input.choice("Method",{value:t.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=o.input.float("Terminal gap",{value:t?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=o.p(`Kalign version: ${u.b9}`,"kalign-version"),g=o.input.float("Gap open",{value:t.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=o.input.float("Gap extend",{value:t.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=o.inputs([g,y,m]),v=o.button("Alignment parameters",(()=>{b.hidden=!b.hidden,[g,y,m].forEach((t=>{t.root.style.removeProperty("max-width"),t.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");v.classList.add("msa-params-button"),b.hidden=!0,v.prepend(o.icons.settings((()=>null)));const w=[p.root.style],C=[m.root.style,f.style];let A,S=d;const x=o.input.column("Sequence",{table:h,value:d,onValueChanged:async t=>{if(!t||t.semType!==r.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,s.cb)(0),void(x.value=S);S=t,_.disabled=!1,A=await T(x.value,h,e,w,C,p,E,g,y,m)},filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE});x.setTooltip("Sequences column to use for alignment");const E=o.input.column("Clusters",{table:h,value:t.clustersCol});E.nullable=!0;const M=o.dialog("MSA").add(x).add(E).add(p).add(b).add(v).add(f).onOK((async()=>{await I(x,h,A,n,a)})),_=M.getButton("OK");if(x.fireChanged(),t.col)return A=await T(t.col,h,e,w,C,p,E,g,y,m),void await I(x,h,A,n,a);M.show()}))}async function I(t,e,n,o,s){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(t.fireChanged(),t.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");e.columns.add(a),await i.data.detectSemanticTypes(e),o(a)}catch(t){s(t)}finally{l.close()}}async function T(t,e,n,o,s,d,p,m,f,g){try{if(t.semType!==r.SEMTYPE.MACROMOLECULE)return;const i=e.columns.getUnusedName(`msa(${t.name})`);if((0,h.l)(t,t.name,n,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT])[0]){L(o,s,"kalign"),m.value=null,f.value=null,g.value=null;const e=n.getSeqHandler(t),r=e.isFasta()?t:e.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(r,!1,i,p.value)}if((0,h.l)(t,t.name,n,[a.Hi.HELM],[])[0])return L(o,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,i,d.value,m.value,f.value,p.value);if((0,h.l)(t,t.name,n,[a.Hi.SEPARATOR],[a.YI.UN])[0]){const e=n.getSeqHandler(t).convert(a.Hi.HELM);return L(o,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(e,i,d.value,m.value,f.value,p.value)}return m.value=null,f.value=null,g.value=null,void L(o,s,"kalign")}catch(t){const e=t instanceof Error?t.message:t.toString();i.shell.error(e),M._package.logger.error(e)}}function L(t,e,n){if("kalign"===n){for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}else{for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}}},608:(t,e,n)=>{"use strict";n.d(e,{Ap:()=>G,aZ:()=>D,eE:()=>H});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),h=Symbol("Comlink.endpoint"),u=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=t=>"object"==typeof t&&null!==t||"function"==typeof t,m=new Map([["proxy",{canHandle:t=>p(t)&&t[c],serialize(t){const{port1:e,port2:n}=new MessageChannel;return f(t,e),[n,[n]]},deserialize:t=>(t.start(),y(t))}],["throw",{canHandle:t=>p(t)&&d in t,serialize({value:t}){let e;return e=t instanceof Error?{isError:!0,value:{message:t.message,name:t.name,stack:t.stack}}:{isError:!1,value:t},[e,[]]},deserialize(t){throw t.isError?Object.assign(new Error(t.value.message),t.value):t.value}}]]);function f(t,e=self){e.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:r,type:o,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const e=s.slice(0,-1).reduce(((t,e)=>t[e]),t),n=s.reduce(((t,e)=>t[e]),t);switch(o){case"GET":l=n;break;case"SET":e[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(e,a);break;case"CONSTRUCT":l=function(t){return Object.assign(t,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:e,port2:n}=new MessageChannel;f(t,n),l=function(t,e){return A.set(t,e),t}(e,[e])}break;case"RELEASE":l=void 0;break;default:return}}catch(t){l={value:t,[d]:0}}Promise.resolve(l).catch((t=>({value:t,[d]:0}))).then((t=>{const[i,s]=S(t);e.postMessage(Object.assign(Object.assign({},i),{id:r}),s),"RELEASE"===o&&(e.removeEventListener("message",n),g(e))}))})),e.start&&e.start()}function g(t){(function(t){return"MessagePort"===t.constructor.name})(t)&&t.close()}function y(t,e){return v(t,[],e)}function b(t){if(t)throw new Error("Proxy has been released and is not useable")}function v(t,e=[],n=function(){}){let i=!1;const r=new Proxy(n,{get(n,o){if(b(i),o===u)return()=>E(t,{type:"RELEASE",path:e.map((t=>t.toString()))}).then((()=>{g(t),i=!0}));if("then"===o){if(0===e.length)return{then:()=>r};const n=E(t,{type:"GET",path:e.map((t=>t.toString()))}).then(x);return n.then.bind(n)}return v(t,[...e,o])},set(n,r,o){b(i);const[s,a]=S(o);return E(t,{type:"SET",path:[...e,r].map((t=>t.toString())),value:s},a).then(x)},apply(n,r,o){b(i);const s=e[e.length-1];if(s===h)return E(t,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(t,e.slice(0,-1));const[a,l]=C(o);return E(t,{type:"APPLY",path:e.map((t=>t.toString())),argumentList:a},l).then(x)},construct(n,r){b(i);const[o,s]=C(r);return E(t,{type:"CONSTRUCT",path:e.map((t=>t.toString())),argumentList:o},s).then(x)}});return r}function w(t){return Array.prototype.concat.apply([],t)}function C(t){const e=t.map(S);return[e.map((t=>t[0])),w(e.map((t=>t[1])))]}const A=new WeakMap;function S(t){for(const[e,n]of m)if(n.canHandle(t)){const[i,r]=n.serialize(t);return[{type:"HANDLER",name:e,value:i},r]}return[{type:"RAW",value:t},A.get(t)||[]]}function x(t){switch(t.type){case"HANDLER":return m.get(t.name).deserialize(t.value);case"RAW":return t.value}}function E(t,e,n){return new Promise((i=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");t.addEventListener("message",(function e(n){!n.data||!n.data.id||n.data.id!==r||(t.removeEventListener("message",e),i(n.data))})),t.start&&t.start(),t.postMessage(Object.assign({id:r},e),n)}))}const M="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",_=typeof window<"u"&&window.Blob&&new Blob([atob(M)],{type:"text/javascript;charset=utf-8"});function I(){const t=_&&(window.URL||window.webkitURL).createObjectURL(_);try{return t?new Worker(t):new Worker("data:application/javascript;base64,"+M)}finally{t&&(window.URL||window.webkitURL).revokeObjectURL(t)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(t,e={}){if(null==t)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(t)||(t=[t]),e=Object.assign({},T,e),t=t.map(this._parseTool),"stg"===e.env&&(e.urlCDN=e.urlCDNStg),this.tools=t,this.config=e,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const t=new I;this.callback&&(t.onmessage=t=>{"biowasm"===t.data.type&&this.callback(t.data.value)});const e=y(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,N.vA)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class ${constructor(t="categorial"){this.aa2num=P.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,n=t.length;const i=["NH2","COOH"];if(t.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==t[n],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=n}if(t.endsWith(i[1])){const e=i[1].length+1;(0,N.vA)("-"==t[n-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),n-=e}return t.substring(e,n)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return $._dropDefises($._truncateSequence(t))}encode(t){const e=t.length,n=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,N.vA)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),n[i]=this.encodeLettter(e)}return n}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let n=0;n<t.length;++n){const i=t[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(t,e){super(t.innerText,e),this.element=t}}function F(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}async function H(t,e=!1,n="",i=null,o,s,c){let h=t.toList();e&&(h=h.map((t=>$.clean(t).replace(/\-/g,""))));const u=t.length;i??=r.Column.string("Clusters",u).init("0"),i.type!=r.COLUMN_TYPE.STRING&&(i=i.convertTo(r.TYPE.STRING)),i.compact();const d=i.categories,p=i.getRawData(),m=new Array(d.length),f=new Array(d.length);for(let t=0;t<u;++t){const e=p[t];(m[e]??=[]).push(h[t]),(f[e]??=[]).push(t)}D(f,d);const g=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=r.Column.string(n,u);for(let t=0;t<d.length;++t){const e=F(m[t]);await g.fs.writeFile(O,e);const n=`${void 0!==o?` --gpo ${o}`:""}${void 0!==s?` --gpe ${s}`:""}${void 0!==c?` --tgpe ${c}`:""}`,i=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(i);const r=await g.cat(k);if(!r){const t=B(i,1);throw new Error(t)}const l=new a.m(r).sequencesArray,h=f[t];for(let t=0;t<l.length;++t)y.set(h[t],l[t])}const b=t.meta.units,v=t.getTag(l.gp.alphabet);return y.meta.units=b,y.setTag(l.gp.aligned,"SEQ.MSA"),y.setTag(l.gp.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(t,e){const n=[],i=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=i.exec(t))&&(void 0===e||n.length<e);)n.push(r[1]);return n.join("\n")}function D(t,e){const n=t.map(((t,e)=>[t,e])).filter((([t,e])=>1==t.length)).map((([t,e])=>e));if(n.length>0){const t=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((t=>{let r=e[t];return r.length>25&&(r=r.slice(0,25)+"..."),i.divText(`"${r}"${t<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new G(t)}}},8152:(t,e,n)=>{"use strict";n.d(e,{GD:()=>d,ZY:()=>h});var i=n(4328),r=n(6082),o=n(2003),s=n(608),a=n(4139),l=n(6766);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],u=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(t,e,n="ginsi",i=1.53,l=0,h=null,d){const m=await c.getDockerContainer(),f=t.length;h??=r.Column.int("Clusters",f).init(0),h.type!=r.COLUMN_TYPE.STRING&&(h=h.convertTo(r.TYPE.STRING));const g=h.categories,y=h.getRawData(),b=new Array(g.length),v=new Array(g.length);for(let e=0;e<f;++e){const n=y[e],i=g[n];if(""===i)continue;const r=g.indexOf(i),o=t.get(e);o&&((b[r]??=[]).push({ID:e.toString(),HELM:o}),(v[n]??=[]).push(e))}(0,s.aZ)(v,g);const w=new Array(f);for(const t of b){const e=(await p(m.id,t,n,i,l,d)).Alignment;for(const t of e)w[parseInt(t.ID)]=Object.entries(t).filter((t=>!u.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(a.J.SEPARATOR)}const C=r.Column.fromStrings(e,w);return C.meta.units=o.Hi.SEPARATOR,C.setTag(o.gp.separator,a.J.SEPARATOR),C.setTag(o.gp.aligned,"SEQ.MSA"),C.setTag(o.gp.alphabet,o.YI.UN),C.setTag(o.gp.alphabetIsMultichar,"true"),C.semType=r.SEMTYPE.MACROMOLECULE,C}async function p(t,e,n,r,o,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},c=`/align?method=${n}&gap_open=${r}&gap_extend=${o}`,h=window.performance.now(),u=await i.dapi.docker.dockerContainers.fetchProxy(t,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-h} ms`);const p="application/json"===u.headers.get("content-type");if(!u.ok&&p){const t=await u.json(),e=t["pepsea-error"];if(e)throw new Error(`PepSeA error: ${e}`);const n=t["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(u.statusText)}if(!u.ok&&!p){const t=await u.text();throw new Error(`Error: ${t}`)}if(!p){const t=await u.text();throw new Error(`Error: PepSeA expected JSON response, got '${t}'.`)}const m=await u.json();if("pepsea-stderr"in m){const t=m["pepsea-stderr"];s?.warning(t)}return m}},3890:(t,e,n)=>{"use strict";n.d(e,{TE:()=>h});var i=n(6082),r=n(7389),o=n(4328),s=n(1991),a=n.n(s),l=n(6766);const c=60;function h(){const t=o.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],h=r.input.multiChoice("Seq id columns",{value:s,items:e.map((t=>t.name))}),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=r.input.choice("Seq column",{value:p,items:d.map((t=>t.name))}),f=r.input.int("FASTA line width",{value:c});r.dialog({title:"Save as FASTA"}).add(r.inputs([h,m,f])).onOK((()=>{const e=h.value?h.value.map((e=>t.columns.byName(e).column)):[],n=m.value?t.columns.byName(m.value).column:null,i=f.value??c;n||o.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(t,e,n=c,i="\n"){const r=[];for(let o=0;o<e.length;o++){const s=t.map((t=>t.get(o).toString())).join("|"),a=u(e.getSplitted(o),n);r.push(`>${s}${i}`);for(const t of a)r.push(`${t}${i}`)}return"".concat(...r)}(e,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),s.setAttribute("download",`${t.dataFrame.name}.fasta`),s.click()})).show()}function u(t,e=c){let n=0;const i=t.length,r=[];for(;n<i;){const i=a().count(n).take(Math.min(t.length-n,e)).map((e=>t.getOriginal(e))).toArray(),o=i.map((t=>t.length>1?`[${t}]`:t)).reduce(((t,e)=>t+e),"");r.push(o),n+=i.length}return r}},8754:(t,e,n)=>{"use strict";n.d(e,{V:()=>h});var i=n(4328),r=n(6077),o=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function h(t,e,n,h,u,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(e);let r,a;i.isHelm()?r=e:(a=e.name,e.name=`__${a}`,r=i.convert(o.Hi.HELM),r.name=a,t.columns.add(r,!1));try{m=await n.helmToAtomicLevel(r,!0,!0,u)}finally{r!==e&&(t.columns.remove(r.name),e.name=a)}}else{if(!(0,l.l)(e,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,r.C4)(t,e,u,d,p)}if(m.molCol){const r=(0,c.qj)(t,e.name);m.molCol.name=r,t.columns.add(m.molCol,!0),await(0,a.Qc)(e,m.molCol,u,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(h)),await i.data.detectSemanticTypes(t)}return m}},4870:(t,e,n)=>{"use strict";n.d(e,{Kd:()=>a,Ku:()=>s,me:()=>o});var i=n(4328),r=n(6082);function o(){const t=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);return null===t?(i.shell.error("Current table does not contain macromolecules"),[]):t}function s(t,e){t.innerHTML="",t.append(e)}function a(t,e,n,i,r){const o=()=>{const r=t.col(e);r&&(r.width=n),i&&(t.props.rowHeight=i)};if(r)return void o();const s=t.onAfterDrawOverlay.subscribe((()=>{s.unsubscribe(),setTimeout((()=>{o()}))}))}},250:(t,e,n)=>{"use strict";n.d(e,{n5:()=>v,oP:()=>I});var i=n(4328),r=n(7389),o=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),h=n(1858),u=n(2003),d=n(4326);function p(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?p(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var m=n(8070),f=n(7602),g=n(439),y=n(6882);var b,v,w=n(2174),C=n(6766);function A(t,e,n){return Math.abs(t-e)<=n}HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new o.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},o.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class S{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(t=0,e){this.value=this.rowCount=t,this.bounds=e}push(t){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=t,++this.valueIdx}aggregate(t){this.value=t(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(t,e,n,i){this.pos=t,this.name=e,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new S),e}aggregate(t){const e=function(t){return e=>{const n=function(t){let e;const n="agg";return e=t instanceof Float32Array?o.Column.fromFloat32Array(n,t):t instanceof Int32Array?o.Column.fromInt32Array(n,t):o.Column.fromList(o.COLUMN_TYPE.FLOAT,n,t),e}(e);return n.aggregate(t)}}(t);for(const[t,n]of Object.entries(this._freqs))n.aggregate(e)}getMinValue(){return Math.min(...Object.values(this._freqs).map((t=>t.value)))}calcPlotValue(t){for(const e of Object.values(this._freqs))e.plotValue=e.value-t}calcHeights(t){this.sumPlotValue=0;for(const t of Object.values(this._freqs))this.sumPlotValue+=t.plotValue;if(this.sumPlotValueForHeight=0,t===d.fH.Entropy){const t=Object.keys(this._freqs).length,e=.01*this.sumPlotValue,n=e/t;for(const t of Object.values(this._freqs)){const i=(t.plotValue+n)/(this.sumPlotValue+e);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(t===d.fH.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=t}}calcScreen(t,e,n,i,r,s,a,l,c){const h=i===d.fH.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort(((t,e)=>t[0]!==g._S&&e[0]!==g._S?e[1].value-t[1].value:t[0]===g._S&&e[0]===g._S?0:t[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((t-e)*l*s,u,a*l,n),u+=n}}render(t,e,n,i,r,o,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;o&&(p=o.getMonomerTextColor(r,a)),t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(d,h.top,h.width,h.height),t.fillStyle=p,t.textAlign="left",t.font=e;const m=t.measureText(c);t.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),t.fillText(c,0,-n)}}getMonomerAt(t,e){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(t,e)));return n?n[0]:void 0}buildCompositionTable(t,e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w.F)(Object.assign({},...Object.entries(this._freqs).map((([t,e])=>({[t]:e.rowCount})))),t,e)}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(b||(b={})),function(t){t.sequenceColumnName="sequenceColumnName",t.valueAggrType="valueAggrType",t.valueColumnName="valueColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.maxMonomerLetters="maxMonomerLetters",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(v||(v={}));const E=d.Fo;var M;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(M||(M={}));const _=new class{render=20};class I extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=C._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,E.sequenceColumnName,{category:b.DATA,semType:o.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const t=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],e=Object.values(o.AGG).filter((e=>!t.includes(e)));this.valueColumnName=this.string(v.valueColumnName,E.valueColumnName,{category:b.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(v.valueAggrType,E.valueAggrType,{category:b.DATA,choices:e,description:"Aggregation method for value column"}),this.startPositionName=this.string(v.startPositionName,E.startPositionName,{category:b.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(v.endPositionName,E.endPositionName,{category:b.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(v.skipEmptySequences,E.skipEmptySequences,{category:b.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,E.skipEmptyPositions,{category:b.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,E.shrinkEmptyTail,{category:b.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(v.backgroundColor,E.backgroundColor,{category:b.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(v.positionHeight,E.positionHeight,{category:b.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,E.positionWidth,{category:b.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(v.verticalAlignment,E.verticalAlignment,{category:b.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,E.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(v.fixWidth,E.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,E.fitArea,{category:b.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(v.minHeight,E.minHeight,{category:b.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(v.maxHeight,E.maxHeight,{category:b.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(v.maxMonomerLetters,E.maxMonomerLetters,{category:b.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(v.showPositionLabels,E.showPositionLabels,{category:b.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(v.positionMarginState,E.positionMarginState,{category:b.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(v.filterSource,E.filterSource,{category:b.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,C.getMonomerLibHelper)().then((t=>{this.monomerLib=t.getMonomerLib(),this.render(M.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(M.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(C._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const t=`${this.toLog()}.setData()`;C._package.logger.debug(`${t}, in`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${t}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(M.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(t){const e={width:t.target.clientWidth,height:t.target.clientHeight};this.lastSize.width==e.width&&this.lastSize.height==e.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(e)}, start `),this.render(M.Layout,"rootOnSizeChanged")),this.lastSize=e}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((t=>t.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(M.Freqs,"updateSeqCol()"),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let t;switch(this.filterSource){case d.lT.Filtered:t=this.dataFrame.filter;break;case d.lT.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=n*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;let e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e);this.fitArea&&e<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/e),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const r=e>n;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*t,this.canvas.height=i*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}safeUpdateSlider(t,e,n,i){A(t,this.slider.minRange,.1)&&A(e,this.slider.maxRange,.1)&&A(n,this.slider.min,.1)&&A(i,this.slider.max,.1)||this.slider.setValues(t,e,n,i)}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(M.Freqs,`onPropertyChanged( ${t.name} )`);break;case v.minHeight:case v.maxHeight:case v.maxMonomerLetters:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(M.Layout,`onPropertyChanged(${t.name})`);break;case v.backgroundColor:this.render(M.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const t=`${this.toLog()}.detach()`;C._package.logger.debug(`${t}, in`);const e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),e())})),C._package.logger.debug(`${t}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const n=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,t.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((t=>!t.hasMonomer(g._S)||t.getFreq(g._S).rowCount!==t.sumRowCount)).toArray())}requestedRenderLevel=M.Freqs;renderRequest=new h.Subject;renderRequestSub;render(t,e){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(t>=M.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.seqCol.getTag(u.gp.positionNames),e=this.seqCol.getTag(u.gp.positionLabels);let n;!t&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):t&&this.endPositionName&&(n=t.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((t=>{const e=this.seqHandler.getSplitted(t,n);return i.get(t)&&e?e.length:0})).reduce(((t,e)=>Math.max(t,e)),0);this.positionNames=t?t.split(u.z1).map((t=>t.trim())):[...Array(r).keys()].map((t=>`${t+1}`)),this.positionLabels=e?e.split(u.z1).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let t=0;t<s;t++){const e=this.positionNames[this.startPosition+t],n=this.positionLabels?this.positionLabels[this.startPosition+t]:void 0;this.positions[t]=new x(this.startPosition+t,e,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let t=0;t<s;++t){for(const e of l){const n=this.seqHandler.getSplitted(e),i=t+this.startPosition<n.length?n.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?g._S:i,o=this.positions[t],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let e=null;try{e=this.dataFrame.getCol(this.valueColumnName),e.matches("numerical")||(e=null)}catch{e=null}if(e){for(const n of l){const i=this.seqHandler.getSplitted(n),r=t+this.startPosition<i.length?i.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===r?g._S:r,s=e.get(n);this.positions[t].getFreq(o).push(s)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((t=>t.getMinValue()))));for(let t=0;t<s;++t)this.positions[t].calcPlotValue(h),this.positions[t].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));t>=M.Layout&&((t,e,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const t=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==t&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(t)}else a=Math.max(...c().count(t).takeWhile((t=>t<=e)).map((t=>this.positions[t].sumPlotValueForHeight)));for(let i=t;i<=e;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(t){const e=o.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const t=10*e;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${t.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(t,e,n,i,r,o,s,a){t.save();try{t.textAlign="center";let l=null,c=null;for(let e=Math.floor(s);e<=Math.floor(a);e++){const n=o[e],i=t.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const h=l<i*e-2?1:(i*e-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],u=(l-s)*n*e+i*e/2,d=(r*e-c)/2;t.setTransform(h,0,0,1,u,d),t.measureText(a.label),t.fillText(a.label,0,0)}}finally{t.restore()}}(a,e,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let t=r;t<=s;t++)this.positions[t].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${t} ), end`)}}renderRequestOnDebounce(t){const e=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=M.None,this.viewSyncer.sync(e,(async()=>{await this.renderInt(t)}))):C._package.logger.warning(`${e}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const e=t.max-t.min,n=this.canvas.offsetWidth/e-this.positionMarginValue;A(n,this.positionWidth,.1)?this.render(M.Layout,"sliderOnValuesChanged"):this.getProperty(v.positionWidth)?.set(this,n)}}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(M.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(M.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){if(!this.monomerLib||!this.seqHandler)return;const e=window.devicePixelRatio;try{const n=t,i=this.canvas.getCursorPosition(n,e),[s,a]=this.getMonomer(i,e),l=this.showPositionLabels?12*e:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const t=[r.divText(`Position ${s.label}`)];if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.seqHandler.defaultBiotype;t.push(s.buildCompositionTable(e,this.monomerLib))}const e=r.divV(t);e.style.maxHeight="80vh",r.tooltip.show(e,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=s.getFreq(a),e=[r.div(`${a}`),r.div(`${t.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&e.push(r.div(`${this.valueAggrType}: ${t.value.toFixed(3)}`));const i=r.divV(e);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(e,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=o.BitSet.create(this.dataFrame.selection.length,(t=>function(t,e,n,i,r,o){const s=e.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),t,r,i)));this.dataFrame.selection.init((e=>t.get(e)))}}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+e)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`invalidate(${t?` <- ${t} `:""})`,n=`${this.toLog()}.${e}`;this.render(M.None,e),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}},1687:(t,e,n)=>{"use strict";n.d(e,{_i:()=>x});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(8115),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(6766);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(t){super(),this.seqHelper=t,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const t of this.viewSubs)t.unsubscribe()}async attach(){this.viewerToLog();try{const t=await(0,g.b2)();let e,n;this.helmEditor=t.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{e=i.div(),n=t.createWebEditorApp(e,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{try{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(t,void 0,v._package.logger)}catch(t){this.logger.error(t)}finally{f()(e).empty(),e=null,n=null}})).onCancel((()=>{f()(e).empty(),e=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((t=>{try{if(n){const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(t)}}catch(t){const[e,n]=(0,y.AP)(t);this.logger.error(e,void 0,n)}})))}catch(t){const[e,n]=(0,y.AP)(t),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,e)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(t){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=e/2;if(t)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,n);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,t)}}async substructureSearch(t){const e=`${this.viewerToLog()}.substructureSearch( column = <${t.name}> )`;v._package.logger.debug(`${e}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,t,this.seqHelper)}finally{v._package.logger.debug(`${e}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(t,e,n,i,r){this.props=t,this.filterId=e,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class S extends p.n{separator;constructor(t,e,n){super(t,!1,n),this.separator=e,this.readOnly=!0}}class x extends r.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(t,e){super(),this.seqHelper=t,this.logger=e,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(t){const e=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{e(t),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=t.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const t=super.detach.bind(this),e=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(e,(async()=>{for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[],t(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(t){t.filterId!==this.filterId&&t.dataFrameId===this.dataFrame.id&&t.columnName===this.columnName&&(this.bioFilter.props=t.props)}applyFilter(){const t=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${t}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=`${this.filterToLog()}.saveState()`,e=super.saveState();return this.logger.debug(`${t}, super.state = ${JSON.stringify(e)}`),e.props=this.bioFilter.saveProps(),e}applyState(t){const e=`${this.filterToLog()}.applyState()`;super.applyState(t),this.filterSyncer.sync(e,(async()=>{t.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(t.props??{}))}))}fireFilterSync(){const t=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${t}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const t=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${t}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(t,(async()=>{this.calculating=!0;try{this.logger.debug(`${t}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${t}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${t}, end`)}}))}grokEventsOnResetFilterRequest(){const t=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${t}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.filterToLog()}.invalidate(${t?` <- ${t} `:""})`;this.filterSyncer.sync(e,(async()=>{this._onRendered.next()}))}async awaitRendered(t=1e4){const e=`awaitRendered( ${t} )`,n=`${this.filterToLog()}.${e}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(e)}),t,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{window.setTimeout((()=>{this.props=new p.n(t,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(t){return(0,d.nI)(this.props.substructure,t)}async attach(){}async detach(){await super.detach()}}class M extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(t){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{this.props=new S(t,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=t,onValueChanged:t=>{const e=t||"";this.props=new S(this.props.substructure,e,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const t=this.props.separator??this.colSeparator;this.separatorInput.value!==t&&(this.separatorInput.value=t)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,d.nI)(this.substructure,t,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(t,e,n)=>{"use strict";n.d(e,{F:()=>E,j:()=>x});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(439),c=n(3599),h=n(5072),u=n.n(h),d=n(7825),p=n.n(d),m=n(7659),f=n.n(m),g=n(5056),y=n.n(g),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(5999),S={};function x(t,e,n){const o=i.div();o.classList.add("macromolecule-cell-comp-analysis-host");const l=t.cell.column.tags[a.gp.alphabet],h=l===a.YI.DNA||l===a.YI.RNA?c.o.NUCLEOTIDE:c.o.AA,u={},d=n.getSeqHandler(t.cell.column),p=t.cell.rowIndex,m=d.getSplitted(p);s().count(0).take(m.length).filter((t=>!m.isGap(t))).forEach((t=>{let e=m.getCanonical(t);h===c.o.NUCLEOTIDE&&d.isHelm()&&"("===e[1]&&")"===e[e.length-2]&&(e=e.substring(2,e.length-2));const n=u[e]||0;u[e]=n+1}));const f=E(u,h,e);return Array.from(f.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),o.appendChild(f),new r.Widget(o)}function E(t,e,n){let o=0,s=null;for(const e of Object.values(t))o+=e,s=null===s?e:Math.max(s,e);const a=s/o,c=Object.assign({},...Array.from(Object.entries(t)).sort(((t,e)=>e[1]-t[1])).map((([t,s])=>{const c=s/o,h=n.getWebEditorMonomer(e,t).backgroundcolor,u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/a+"px",u.style.backgroundColor=h,l._S===t&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=r.Color.toHtml(r.Color.lightGray));const d=l._S===t?"-":t,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),h}S.styleTagTransform=C(),S.setAttributes=y(),S.insert=f().bind(null,"head"),S.domAPI=p(),S.insertStyleElement=v(),u()(A.A,S),A.A&&A.A.locals&&A.A.locals},1757:t=>{"use strict";t.exports=$},6082:t=>{"use strict";t.exports=DG},4328:t=>{"use strict";t.exports=grok},1858:t=>{"use strict";t.exports=rxjs},9713:t=>{"use strict";t.exports=rxjs.operators},7389:t=>{"use strict";t.exports=ui},1991:t=>{"use strict";t.exports=wu},8343:(t,e,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:r,removeDotSegments:o,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(t,e,n,i){const r={};return i||(t=p(h(t,n),n),e=p(h(e,n),n)),!(n=n||{}).tolerant&&e.scheme?(r.scheme=e.scheme,r.userinfo=e.userinfo,r.host=e.host,r.port=e.port,r.path=o(e.path||""),r.query=e.query):(void 0!==e.userinfo||void 0!==e.host||void 0!==e.port?(r.userinfo=e.userinfo,r.host=e.host,r.port=e.port,r.path=o(e.path||""),r.query=e.query):(e.path?("/"===e.path.charAt(0)?r.path=o(e.path):(void 0===t.userinfo&&void 0===t.host&&void 0===t.port||t.path?t.path?r.path=t.path.slice(0,t.path.lastIndexOf("/")+1)+e.path:r.path=e.path:r.path="/"+e.path,r.path=o(r.path)),r.query=e.query):(r.path=t.path,void 0!==e.query?r.query=e.query:r.query=t.query),r.userinfo=t.userinfo,r.host=t.host,r.port=t.port),r.scheme=t.scheme),r.fragment=e.fragment,r}function h(t,e){const n={host:t.host,scheme:t.scheme,userinfo:t.userinfo,port:t.port,path:t.path,query:t.query,nid:t.nid,nss:t.nss,uuid:t.uuid,fragment:t.fragment,reference:t.reference,resourceName:t.resourceName,secure:t.secure,error:""},i=Object.assign({},e),r=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&r.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&r.push("//"),r.push(c),n.path&&"/"!==n.path.charAt(0)&&r.push("/")),void 0!==n.path){let t=n.path;i.absolutePath||a&&a.absolutePath||(t=o(t)),void 0===c&&(t=t.replace(/^\/\//u,"/%2F")),r.push(t)}return void 0!==n.query&&r.push("?",n.query),void 0!==n.fragment&&r.push("#",n.fragment),r.join("")}const u=Array.from({length:127},((t,e)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(e)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(t,e){const n=Object.assign({},e),o={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==t.indexOf("%");let a=!1;"suffix"===n.reference&&(t=(n.scheme?n.scheme+":":"")+"//"+t);const c=t.match(d);if(c){if(o.scheme=c[1],o.userinfo=c[3],o.host=c[4],o.port=parseInt(c[5],10),o.path=c[6]||"",o.query=c[7],o.fragment=c[8],isNaN(o.port)&&(o.port=c[5]),o.host){const t=r(o.host);if(!1===t.isIPV4){const e=i(t.host);o.host=e.host.toLowerCase(),a=e.isIPV6}else o.host=t.host,a=!0}void 0!==o.scheme||void 0!==o.userinfo||void 0!==o.host||void 0!==o.port||void 0!==o.query||o.path?void 0===o.scheme?o.reference="relative":void 0===o.fragment?o.reference="absolute":o.reference="uri":o.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==o.reference&&(o.error=o.error||"URI is not a "+n.reference+" reference.");const t=l[(n.scheme||o.scheme||"").toLowerCase()];if(!(n.unicodeSupport||t&&t.unicodeSupport)&&o.host&&(n.domainHost||t&&t.domainHost)&&!1===a&&function(t){let e=0;for(let n=0,i=t.length;n<i;++n)if(e=t.charCodeAt(n),e>126||u[e])return!0;return!1}(o.host))try{o.host=URL.domainToASCII(o.host.toLowerCase())}catch(t){o.error=o.error||"Host's domain name can not be converted to ASCII: "+t}(!t||t&&!t.skipNormalize)&&(s&&void 0!==o.scheme&&(o.scheme=unescape(o.scheme)),s&&void 0!==o.host&&(o.host=unescape(o.host)),o.path&&(o.path=escape(unescape(o.path))),o.fragment&&(o.fragment=encodeURI(decodeURIComponent(o.fragment)))),t&&t.parse&&t.parse(o,n)}else o.error=o.error||"URI can not be parsed.";return o}const m={SCHEMES:l,normalize:function(t,e){return"string"==typeof t?t=h(p(t,e),e):"object"==typeof t&&(t=p(h(t,e),e)),t},resolve:function(t,e,n){const i=Object.assign({scheme:"null"},n);return h(c(p(t,i),p(e,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(t,e,n){return"string"==typeof t?(t=unescape(t),t=h(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=h(a(t,!0),{...n,skipEscape:!0})),"string"==typeof e?(e=unescape(e),e=h(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=h(a(e,!0),{...n,skipEscape:!0})),t.toLowerCase()===e.toLowerCase()},serialize:h,parse:p};t.exports=m,t.exports.default=m,t.exports.fastUri=m},343:t=>{"use strict";const e=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(t){return"boolean"==typeof t.secure?t.secure:"wss"===String(t.scheme).toLowerCase()}function r(t){return t.host||(t.error=t.error||"HTTP URIs must have a host."),t}function o(t){const e="https"===String(t.scheme).toLowerCase();return t.port!==(e?443:80)&&""!==t.port||(t.port=void 0),t.path||(t.path="/"),t}const s={scheme:"http",domainHost:!0,parse:r,serialize:o},a={scheme:"ws",domainHost:!0,parse:function(t){return t.secure=i(t),t.resourceName=(t.path||"/")+(t.query?"?"+t.query:""),t.path=void 0,t.query=void 0,t},serialize:function(t){if(t.port!==(i(t)?443:80)&&""!==t.port||(t.port=void 0),"boolean"==typeof t.secure&&(t.scheme=t.secure?"wss":"ws",t.secure=void 0),t.resourceName){const[e,n]=t.resourceName.split("?");t.path=e&&"/"!==e?e:void 0,t.query=n,t.resourceName=void 0}return t.fragment=void 0,t}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:r,serialize:o},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(t,e){if(!t.path)return t.error="URN can not be parsed",t;const i=t.path.match(n);if(i){const n=e.scheme||t.scheme||"urn";t.nid=i[1].toLowerCase(),t.nss=i[2];const r=`${n}:${e.nid||t.nid}`,o=l[r];t.path=void 0,o&&(t=o.parse(t,e))}else t.error=t.error||"URN can not be parsed.";return t},serialize:function(t,e){const n=e.scheme||t.scheme||"urn",i=t.nid.toLowerCase(),r=`${n}:${e.nid||i}`,o=l[r];o&&(t=o.serialize(t,e));const s=t,a=t.nss;return s.path=`${i||e.nid}:${a}`,e.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(t,n){const i=t;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&e.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(t){const e=t;return e.nss=(t.uuid||"").toLowerCase(),e},skipNormalize:!0}};t.exports=l},4914:t=>{"use strict";t.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(t,e,n)=>{"use strict";const{HEX:i}=n(4914),r=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function o(t){if(c(t,".")<3)return{host:t,isIPV4:!1};const e=t.match(r)||[],[n]=e;return n?{host:l(n,"."),isIPV4:!0}:{host:t,isIPV4:!1}}function s(t,e=!1){let n="",r=!0;for(const e of t){if(void 0===i[e])return;"0"!==e&&!0===r&&(r=!1),r||(n+=e)}return e&&0===n.length&&(n="0"),n}function a(t){if(c(t,":")<2)return{host:t,isIPV6:!1};const e=function(t){let e=0;const n={error:!1,address:"",zone:""},i=[],r=[];let o=!1,a=!1,l=!1;function c(){if(r.length){if(!1===o){const t=s(r);if(void 0===t)return n.error=!0,!1;i.push(t)}r.length=0}return!0}for(let s=0;s<t.length;s++){const h=t[s];if("["!==h&&"]"!==h)if(":"!==h)if("%"===h){if(!c())break;o=!0}else r.push(h);else{if(!0===a&&(l=!0),!c())break;if(e++,i.push(":"),e>7){n.error=!0;break}s-1>=0&&":"===t[s-1]&&(a=!0)}}return r.length&&(o?n.zone=r.join(""):l?i.push(r.join("")):i.push(s(r))),n.address=i.join(""),n}(t);if(e.error)return{host:t,isIPV6:!1};{let t=e.address,n=e.address;return e.zone&&(t+="%"+e.zone,n+="%25"+e.zone),{host:t,escapedHost:n,isIPV6:!0}}}function l(t,e){let n="",i=!0;const r=t.length;for(let o=0;o<r;o++){const s=t[o];"0"===s&&i?(o+1<=r&&t[o+1]===e||o+1===r)&&(n+=s,i=!1):(i=s===e,n+=s)}return n}function c(t,e){let n=0;for(let i=0;i<t.length;i++)t[i]===e&&n++;return n}const h=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,p=/^\/?(?:.|\n)*?(?=\/|$)/u;t.exports={recomposeAuthority:function(t){const e=[];if(void 0!==t.userinfo&&(e.push(t.userinfo),e.push("@")),void 0!==t.host){let n=unescape(t.host);const i=o(n);if(i.isIPV4)n=i.host;else{const e=a(i.host);n=!0===e.isIPV6?`[${e.escapedHost}]`:t.host}e.push(n)}return"number"!=typeof t.port&&"string"!=typeof t.port||(e.push(":"),e.push(String(t.port))),e.length?e.join(""):void 0},normalizeComponentEncoding:function(t,e){const n=!0!==e?escape:unescape;return void 0!==t.scheme&&(t.scheme=n(t.scheme)),void 0!==t.userinfo&&(t.userinfo=n(t.userinfo)),void 0!==t.host&&(t.host=n(t.host)),void 0!==t.path&&(t.path=n(t.path)),void 0!==t.query&&(t.query=n(t.query)),void 0!==t.fragment&&(t.fragment=n(t.fragment)),t},removeDotSegments:function(t){const e=[];for(;t.length;)if(t.match(h))t=t.replace(h,"");else if(t.match(u))t=t.replace(u,"/");else if(t.match(d))t=t.replace(d,"/"),e.pop();else if("."===t||".."===t)t="";else{const n=t.match(p);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];t=t.slice(i.length),e.push(i)}}return e.join("")},normalizeIPv4:o,normalizeIPv6:a,stringArrayToHexStripped:s}},3837:t=>{"use strict";t.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:t=>{"use strict";t.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},e={};function n(i){var r=e[i];if(void 0!==r)return r.exports;var o=e[i]={id:i,loaded:!1,exports:{}};return t[i].call(o.exports,o,o.exports,n),o.loaded=!0,o.exports}n.m=t,n.amdO={},n.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return n.d(e,{a:e}),e},n.d=(t,e)=>{for(var i in e)n.o(e,i)&&!n.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},n.u=t=>t+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),n.hmd=t=>((t=Object.create(t)).children||(t.children=[]),Object.defineProperty(t,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+t.id)}}),t),n.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),n.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;n.g.importScripts&&(t=n.g.location+"");var e=n.g.document;if(!t&&e&&(e.currentScript&&"SCRIPT"===e.currentScript.tagName.toUpperCase()&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var r=i.length-1;r>-1&&(!t||!/^http(s?):/.test(t));)t=i[r--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=t})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(6766);bio=i})();
+    deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:e.error,code(t){const[e,n]=function({schema:t}){const e={},n={};for(const i in t)"__proto__"!==i&&((Array.isArray(t[i])?e:n)[i]=t[i]);return[e,n]}(t);a(t,e),l(t,n)}};function a(t,e=t.schema){const{gen:n,data:r,it:s}=t;if(0===Object.keys(e).length)return;const a=n.let("missing");for(const l in e){const c=e[l];if(0===c.length)continue;const h=(0,o.propertyInData)(n,r,l,s.opts.ownProperties);t.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(h,(()=>{for(const e of c)(0,o.checkReportMissingProp)(t,e)})):(n.if(i._`${h} && (${(0,o.checkMissingProp)(t,c,a)})`),(0,o.reportMissingProp)(t,a),n.else())}}function l(t,e=t.schema){const{gen:n,data:i,keyword:s,it:a}=t,l=n.name("valid");for(const c in e)(0,r.alwaysValidSchema)(a,e[c])||(n.if((0,o.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const e=t.subschema({keyword:s,schemaProp:c},l);t.mergeValidEvaluated(e,l)}),(()=>n.var(l,!0))),t.ok(l))}e.validatePropertyDeps=a,e.validateSchemaDeps=l,e.default=s},4845:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:t=>(0,i.validateSchemaDeps)(t)};e.default=r},1239:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:t})=>i.str`must match "${t.ifClause}" schema`,params:({params:t})=>i._`{failingKeyword: ${t.ifClause}}`},code(t){const{gen:e,parentSchema:n,it:o}=t;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(o,'"if" without "then" and "else" is ignored');const a=s(o,"then"),l=s(o,"else");if(!a&&!l)return;const c=e.let("valid",!0),h=e.name("_valid");if(function(){const e=t.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},h);t.mergeEvaluated(e)}(),t.reset(),a&&l){const n=e.let("ifClause");t.setParams({ifClause:n}),e.if(h,u("then",n),u("else",n))}else a?e.if(h,u("then")):e.if((0,i.not)(h),u("else"));function u(n,r){return()=>{const o=t.subschema({keyword:n},h);e.assign(c,h),t.mergeValidEvaluated(o,c),r?e.assign(r,i._`${n}`):t.setParams({ifClause:n})}}t.pass(c,(()=>t.error(!0)))}};function s(t,e){const n=t.schema[e];return void 0!==n&&!(0,r.alwaysValidSchema)(t,n)}e.default=o},6378:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5457),r=n(5354),o=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(2094),h=n(8660),u=n(117),d=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),b=n(4426);e.default=function(t=!1){const e=[p.default,m.default,f.default,g.default,y.default,b.default,c.default,h.default,l.default,u.default,d.default];return t?e.push(r.default,s.default):e.push(i.default,o.default),e.push(a.default),e}},494:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateTuple=void 0;const i=n(9029),r=n(4227),o=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(t){const{schema:e,it:n}=t;if(Array.isArray(e))return a(t,"additionalItems",e);n.items=!0,(0,r.alwaysValidSchema)(n,e)||t.ok((0,o.validateArray)(t))}};function a(t,e,n=t.schema){const{gen:o,parentSchema:s,data:a,keyword:l,it:c}=t;!function(t){const{opts:i,errSchemaPath:o}=c,s=n.length,a=s===t.minItems&&(s===t.maxItems||!1===t[e]);if(i.strictTuples&&!a){const t=`"${l}" is ${s}-tuple, but minItems or maxItems/${e} are not specified or different at path "${o}"`;(0,r.checkStrictMode)(c,t,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(o,n.length,c.items));const h=o.name("valid"),u=o.const("len",i._`${a}.length`);n.forEach(((e,n)=>{(0,r.alwaysValidSchema)(c,e)||(o.if(i._`${u} > ${n}`,(()=>t.subschema({keyword:l,schemaProp:n,dataProp:n},h))),t.ok(h))}))}e.validateTuple=a,e.default=s},3966:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{schema:e,parentSchema:n,it:i}=t,{prefixItems:a}=n;i.items=!0,(0,r.alwaysValidSchema)(i,e)||(a?(0,s.validateAdditionalItems)(t,a):t.ok((0,o.validateArray)(t)))}};e.default=a},7923:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(t){const{gen:e,schema:n,it:r}=t;if((0,i.alwaysValidSchema)(r,n))return void t.fail();const o=e.name("valid");t.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},o),t.failResult(o,(()=>t.reset()),(()=>t.error()))},error:{message:"must NOT be valid"}};e.default=r},6163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:t})=>i._`{passingSchemas: ${t.passing}}`},code(t){const{gen:e,schema:n,parentSchema:o,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&o.discriminator)return;const a=n,l=e.let("valid",!1),c=e.let("passing",null),h=e.name("_valid");t.setParams({passing:c}),e.block((function(){a.forEach(((n,o)=>{let a;(0,r.alwaysValidSchema)(s,n)?e.var(h,!0):a=t.subschema({keyword:"oneOf",schemaProp:o,compositeRule:!0},h),o>0&&e.if(i._`${h} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${o}]`).else(),e.if(h,(()=>{e.assign(l,!0),e.assign(c,o),a&&t.mergeEvaluated(a,i.Name)}))}))})),t.result(l,(()=>t.reset()),(()=>t.error(!0)))}};e.default=o},5333:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,data:a,parentSchema:l,it:c}=t,{opts:h}=c,u=(0,i.allSchemaProperties)(n),d=u.filter((t=>(0,o.alwaysValidSchema)(c,n[t])));if(0===u.length||d.length===u.length&&(!c.opts.unevaluated||!0===c.props))return;const p=h.strictSchema&&!h.allowMatchingProperties&&l.properties,m=e.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,s.evaluatedPropsToName)(e,c.props));const{props:f}=c;function g(t){for(const e in p)new RegExp(t).test(e)&&(0,o.checkStrictMode)(c,`property ${e} matches pattern ${t} (use allowMatchingProperties)`)}function y(n){e.forIn("key",a,(o=>{e.if(r._`${(0,i.usePattern)(t,n)}.test(${o})`,(()=>{const i=d.includes(n);i||t.subschema({keyword:"patternProperties",schemaProp:n,dataProp:o,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==f?e.assign(r._`${f}[${o}]`,!0):i||c.allErrors||e.if((0,r.not)(m),(()=>e.break()))}))}))}!function(){for(const t of u)p&&g(t),c.allErrors?y(t):(e.var(m,!0),y(t),e.if(m))}()}};e.default=a},5354:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(494),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:t=>(0,i.validateTuple)(t,"items")};e.default=r},117:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2586),r=n(5765),o=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(t){const{gen:e,schema:n,parentSchema:a,data:l,it:c}=t;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const h=(0,r.allSchemaProperties)(n);for(const t of h)c.definedProperties.add(t);c.opts.unevaluated&&h.length&&!0!==c.props&&(c.props=o.mergeEvaluated.props(e,(0,o.toHash)(h),c.props));const u=h.filter((t=>!(0,o.alwaysValidSchema)(c,n[t])));if(0===u.length)return;const d=e.name("valid");for(const n of u)p(n)?m(n):(e.if((0,r.propertyInData)(e,l,n,c.opts.ownProperties)),m(n),c.allErrors||e.else().var(d,!0),e.endIf()),t.it.definedProperties.add(n),t.ok(d);function p(t){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[t].default}function m(e){t.subschema({keyword:"properties",schemaProp:e,dataProp:e},d)}}};e.default=a},2094:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:t})=>i._`{propertyName: ${t.propertyName}}`},code(t){const{gen:e,schema:n,data:o,it:s}=t;if((0,r.alwaysValidSchema)(s,n))return;const a=e.name("valid");e.forIn("key",o,(n=>{t.setParams({propertyName:n}),t.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),e.if((0,i.not)(a),(()=>{t.error(!0),s.allErrors||e.break()}))})),t.ok(a)}};e.default=o},4426:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:t,parentSchema:e,it:n}){void 0===e.if&&(0,i.checkStrictMode)(n,`"${t}" without "if" is ignored`)}};e.default=r},5765:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.validateUnion=e.validateArray=e.usePattern=e.callValidateCode=e.schemaProperties=e.allSchemaProperties=e.noPropertyInData=e.propertyInData=e.isOwnProperty=e.hasPropFunc=e.reportMissingProp=e.checkMissingProp=e.checkReportMissingProp=void 0;const i=n(9029),r=n(4227),o=n(2023),s=n(4227);function a(t){return t.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(t,e,n){return i._`${a(t)}.call(${e}, ${n})`}function c(t,e,n,r){const o=i._`${e}${(0,i.getProperty)(n)} === undefined`;return r?(0,i.or)(o,(0,i.not)(l(t,e,n))):o}function h(t){return t?Object.keys(t).filter((t=>"__proto__"!==t)):[]}e.checkReportMissingProp=function(t,e){const{gen:n,data:r,it:o}=t;n.if(c(n,r,e,o.opts.ownProperties),(()=>{t.setParams({missingProperty:i._`${e}`},!0),t.error()}))},e.checkMissingProp=function({gen:t,data:e,it:{opts:n}},r,o){return(0,i.or)(...r.map((r=>(0,i.and)(c(t,e,r,n.ownProperties),i._`${o} = ${r}`))))},e.reportMissingProp=function(t,e){t.setParams({missingProperty:e},!0),t.error()},e.hasPropFunc=a,e.isOwnProperty=l,e.propertyInData=function(t,e,n,r){const o=i._`${e}${(0,i.getProperty)(n)} !== undefined`;return r?i._`${o} && ${l(t,e,n)}`:o},e.noPropertyInData=c,e.allSchemaProperties=h,e.schemaProperties=function(t,e){return h(e).filter((n=>!(0,r.alwaysValidSchema)(t,e[n])))},e.callValidateCode=function({schemaCode:t,data:e,it:{gen:n,topSchemaRef:r,schemaPath:s,errorPath:a},it:l},c,h,u){const d=u?i._`${t}, ${e}, ${r}${s}`:e,p=[[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,a)],[o.default.parentData,l.parentData],[o.default.parentDataProperty,l.parentDataProperty],[o.default.rootData,o.default.rootData]];l.opts.dynamicRef&&p.push([o.default.dynamicAnchors,o.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return h!==i.nil?i._`${c}.call(${h}, ${m})`:i._`${c}(${m})`};const u=i._`new RegExp`;e.usePattern=function({gen:t,it:{opts:e}},n){const r=e.unicodeRegExp?"u":"",{regExp:o}=e.code,a=o(n,r);return t.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===o.code?u:(0,s.useFunc)(t,o)}(${n}, ${r})`})},e.validateArray=function(t){const{gen:e,data:n,keyword:o,it:s}=t,a=e.name("valid");if(s.allErrors){const t=e.let("valid",!0);return l((()=>e.assign(t,!1))),t}return e.var(a,!0),l((()=>e.break())),a;function l(s){const l=e.const("len",i._`${n}.length`);e.forRange("i",0,l,(n=>{t.subschema({keyword:o,dataProp:n,dataPropType:r.Type.Num},a),e.if((0,i.not)(a),s)}))}},e.validateUnion=function(t){const{gen:e,schema:n,keyword:o,it:s}=t;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((t=>(0,r.alwaysValidSchema)(s,t)))&&!s.opts.unevaluated)return;const a=e.let("valid",!1),l=e.name("_valid");e.block((()=>n.forEach(((n,r)=>{const s=t.subschema({keyword:o,schemaProp:r,compositeRule:!0},l);e.assign(a,i._`${a} || ${l}`),t.mergeValidEvaluated(s,l)||e.if((0,i.not)(a))})))),t.result(a,(()=>t.reset()),(()=>t.error(!0)))}},3463:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};e.default=n},2128:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3463),r=n(3693),o=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,r.default];e.default=o},3693:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.callRef=e.getValidate=void 0;const i=n(4551),r=n(5765),o=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(t){const{gen:e,schema:n,it:r}=t,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=r,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return u(t,c,l,l.$async);const n=e.scopeValue("root",{ref:m});return u(t,o._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,s,n);if(void 0===f)throw new i.default(r.opts.uriResolver,s,n);return f instanceof a.SchemaEnv?function(e){const n=h(t,e);u(t,n,e,e.$async)}(f):function(i){const r=e.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,o.stringify)(i)}:{ref:i}),s=e.name("valid"),a=t.subschema({schema:i,dataTypes:[],schemaPath:o.nil,topSchemaRef:r,errSchemaPath:n},s);t.mergeEvaluated(a),t.ok(s)}(f)}};function h(t,e){const{gen:n}=t;return e.validate?n.scopeValue("validate",{ref:e.validate}):o._`${n.scopeValue("wrapper",{ref:e})}.validate`}function u(t,e,n,i){const{gen:a,it:c}=t,{allErrors:h,schemaEnv:u,opts:d}=c,p=d.passContext?s.default.this:o.nil;function m(t){const e=o._`${t}.errors`;a.assign(s.default.vErrors,o._`${s.default.vErrors} === null ? ${e} : ${s.default.vErrors}.concat(${e})`),a.assign(s.default.errors,o._`${s.default.vErrors}.length`)}function f(t){var e;if(!c.opts.unevaluated)return;const i=null===(e=null==n?void 0:n.validate)||void 0===e?void 0:e.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const e=a.var("props",o._`${t}.evaluated.props`);c.props=l.mergeEvaluated.props(a,e,c.props,o.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const e=a.var("items",o._`${t}.evaluated.items`);c.items=l.mergeEvaluated.items(a,e,c.items,o.Name)}}i?function(){if(!u.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(o._`await ${(0,r.callValidateCode)(t,e,p)}`),f(e),h||a.assign(n,!0)}),(t=>{a.if(o._`!(${t} instanceof ${c.ValidationError})`,(()=>a.throw(t))),m(t),h||a.assign(n,!1)})),t.ok(n)}():t.result((0,r.callValidateCode)(t,e,p),(()=>f(e)),(()=>m(e)))}e.getValidate=h,e.callRef=u,e.default=c},6653:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(7652),o=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:t,tagName:e}})=>t===r.DiscrError.Tag?`tag "${e}" must be string`:`value of tag "${e}" must be in oneOf`,params:({params:{discrError:t,tag:e,tagName:n}})=>i._`{error: ${t}, tag: ${n}, tagValue: ${e}}`},code(t){const{gen:e,data:n,schema:l,parentSchema:c,it:h}=t,{oneOf:u}=c;if(!h.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!u)throw new Error("discriminator: requires oneOf keyword");const p=e.let("valid",!1),m=e.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function f(n){const r=e.name("valid"),o=t.subschema({keyword:"oneOf",schemaProp:n},r);return t.mergeEvaluated(o,i.Name),r}e.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var t;const e={},n=r(c);let i=!0;for(let e=0;e<u.length;e++){let c=u[e];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,h.self.RULES)){const t=c.$ref;if(c=o.resolveRef.call(h.self,h.schemaEnv.root,h.baseId,t),c instanceof o.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(h.opts.uriResolver,h.baseId,t)}const p=null===(t=null==c?void 0:c.properties)||void 0===t?void 0:t[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||r(c)),l(p,e)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return e;function r({required:t}){return Array.isArray(t)&&t.includes(d)}function l(t,e){if(t.const)p(t.const,e);else{if(!t.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of t.enum)p(n,e)}}function p(t,n){if("string"!=typeof t||t in e)throw new Error(`discriminator: "${d}" values must be unique strings`);e[t]=n}}();e.if(!1);for(const t in n)e.elseIf(i._`${m} === ${t}`),e.assign(p,f(n[t]));e.else(),t.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:d}),e.endIf()}()),(()=>t.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:d}))),t.ok(p)}};e.default=l},7652:(t,e)=>{"use strict";var n;Object.defineProperty(e,"__esModule",{value:!0}),e.DiscrError=void 0,function(t){t.Tag="tag",t.Mapping="mapping"}(n||(e.DiscrError=n={}))},6105:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),h=n(9857),u=[s.default,i.default,r.default,(0,o.default)(!0),c.default,h.metadataVocabulary,h.contentVocabulary,a.default,l.default];e.default=u},6144:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(7532),a=n(9857),l=[i.default,r.default,(0,o.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];e.default=l},2476:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicAnchor=void 0;const i=n(9029),r=n(2023),o=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:t=>l(t,t.schema)};function l(t,e){const{gen:n,it:a}=t;a.schemaEnv.root.dynamicAnchors[e]=!0;const l=i._`${r.default.dynamicAnchors}${(0,i.getProperty)(e)}`,c="#"===a.errSchemaPath?a.validateName:function(t){const{schemaEnv:e,schema:n,self:i}=t.it,{root:r,baseId:a,localRefs:l,meta:c}=e.root,{schemaId:h}=i.opts,u=new o.SchemaEnv({schema:n,schemaId:h,root:r,baseId:a,localRefs:l,meta:c});return o.compileSchema.call(i,u),(0,s.getValidate)(t,u)}(t);n.if(i._`!${l}`,(()=>n.assign(l,c)))}e.dynamicAnchor=l,e.default=a},3252:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.dynamicRef=void 0;const i=n(9029),r=n(2023),o=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:t=>a(t,t.schema)};function a(t,e){const{gen:n,keyword:s,it:a}=t;if("#"!==e[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=e.slice(1);if(a.allErrors)c();else{const e=n.let("valid",!1);c(e),t.ok(e)}function c(t){if(a.schemaEnv.root.dynamicAnchors[l]){const e=n.let("_v",i._`${r.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(e,h(e,t),h(a.validateName,t))}else h(a.validateName,t)()}function h(e,i){return i?()=>n.block((()=>{(0,o.callRef)(t,e),n.let(i,!0)})):()=>(0,o.callRef)(t,e)}}e.dynamicRef=a,e.default=s},5520:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),r=n(3252),o=n(2721),s=n(3799),a=[i.default,r.default,o.default,s.default];e.default=a},2721:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(2476),r=n(4227),o={keyword:"$recursiveAnchor",schemaType:"boolean",code(t){t.schema?(0,i.dynamicAnchor)(t,""):(0,r.checkStrictMode)(t.it,"$recursiveAnchor: false is ignored")}};e.default=o},3799:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3252),r={keyword:"$recursiveRef",schemaType:"string",code:t=>(0,i.dynamicRef)(t,t.schema)};e.default=r},4737:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>i.str`must match format "${t}"`,params:({schemaCode:t})=>i._`{format: ${t}}`},code(t,e){const{gen:n,data:r,$data:o,schema:s,schemaCode:a,it:l}=t,{opts:c,errSchemaPath:h,schemaEnv:u,self:d}=l;c.validateFormats&&(o?function(){const o=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${o}[${a}]`),l=n.let("fType"),h=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(h,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(h,s))),t.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${h}`,function(){const t=u.$async?i._`(${s}.async ? await ${h}(${r}) : ${h}(${r}))`:i._`${h}(${r})`,n=i._`(typeof ${h} == "function" ? ${t} : ${h}.test(${r}))`;return i._`${h} && ${h} !== true && ${l} === ${e} && !${n}`}()))}():function(){const o=d.formats[s];if(!o)return void function(){if(!1!==c.strictSchema)throw new Error(t());function t(){return`unknown format "${s}" ignored in schema at path "${h}"`}d.logger.warn(t())}();if(!0===o)return;const[a,l,p]=function(t){const e=t instanceof RegExp?(0,i.regexpCode)(t):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,r=n.scopeValue("formats",{key:s,ref:t,code:e});return"object"!=typeof t||t instanceof RegExp?["string",t,r]:[t.type||"string",t.validate,i._`${r}.validate`]}(o);a===e&&t.pass(function(){if("object"==typeof o&&!(o instanceof RegExp)&&o.async){if(!u.$async)throw new Error("async format in sync schema");return i._`await ${p}(${r})`}return"function"==typeof l?i._`${p}(${r})`:i._`${p}.test(${r})`}())}())}};e.default=r},7532:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=[n(4737).default];e.default=i},9857:(t,e)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0}),e.contentVocabulary=e.metadataVocabulary=void 0,e.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],e.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(1846),r=n(4845),o=n(2626),s=[i.default,r.default,o.default];e.default=s},3265:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(392),r=n(3445),o=[i.default,r.default];e.default=o},3445:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:t}})=>i.str`must NOT have more than ${t} items`,params:({params:{len:t}})=>i._`{limit: ${t}}`},code(t){const{gen:e,schema:n,data:o,it:s}=t,a=s.items||0;if(!0===a)return;const l=e.const("len",i._`${o}.length`);if(!1===n)t.setParams({len:a}),t.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(s,n)){const n=e.var("valid",i._`${l} <= ${a}`);e.if((0,i.not)(n),(()=>function(n,o){e.forRange("i",o,l,(o=>{t.subschema({keyword:"unevaluatedItems",dataProp:o,dataPropType:r.Type.Num},n),s.allErrors||e.if((0,i.not)(n),(()=>e.break()))}))}(n,a))),t.ok(n)}s.items=!0}};e.default=o},392:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:t})=>i._`{unevaluatedProperty: ${t.unevaluatedProperty}}`},code(t){const{gen:e,schema:n,data:s,errsCount:a,it:l}=t;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:h}=l;function u(o){if(!1===n)return t.setParams({unevaluatedProperty:o}),t.error(),void(c||e.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=e.name("valid");t.subschema({keyword:"unevaluatedProperties",dataProp:o,dataPropType:r.Type.Str},n),c||e.if((0,i.not)(n),(()=>e.break()))}}h instanceof i.Name?e.if(i._`${h} !== true`,(()=>e.forIn("key",s,(t=>e.if(function(t,e){return i._`!${t} || !${t}[${e}]`}(h,t),(()=>u(t))))))):!0!==h&&e.forIn("key",s,(t=>void 0===h?u(t):e.if(function(t,e){const n=[];for(const r in t)!0===t[r]&&n.push(i._`${e} !== ${r}`);return(0,i.and)(...n)}(h,t),(()=>u(t))))),l.props=!0,t.ok(i._`${a} === ${o.default.errors}`)}};e.default=s},7935:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:t})=>i._`{allowedValue: ${t}}`},code(t){const{gen:e,data:n,$data:s,schemaCode:a,schema:l}=t;s||l&&"object"==typeof l?t.fail$data(i._`!${(0,r.useFunc)(e,o.default)}(${n}, ${a})`):t.fail(i._`${l} !== ${n}`)}};e.default=s},1846:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:t=>(0,i.validatePropertyDeps)(t)};e.default=r},8643:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:t})=>i._`{allowedValues: ${t}}`},code(t){const{gen:e,data:n,$data:s,schema:a,schemaCode:l,it:c}=t;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const h=a.length>=c.opts.loopEnum;let u;const d=()=>null!=u?u:u=(0,r.useFunc)(e,o.default);let p;if(h||s)p=e.let("valid"),t.block$data(p,(function(){e.assign(p,!1),e.forOf("v",l,(t=>e.if(i._`${d()}(${n}, ${t})`,(()=>e.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const t=e.const("vSchema",l);p=(0,i.or)(...a.map(((e,r)=>function(t,e){const r=a[e];return"object"==typeof r&&null!==r?i._`${d()}(${n}, ${t}[${e}])`:i._`${n} === ${r}`}(t,r))))}t.pass(p)}};e.default=s},7060:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5882),r=n(3439),o=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),h=n(617),u=n(7935),d=n(8643),p=[i.default,r.default,o.default,s.default,a.default,l.default,c.default,h.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},u.default,d.default];e.default=p},2626:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(4227),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:t,parentSchema:e,it:n}){void 0===e.contains&&(0,i.checkStrictMode)(n,`"${t}" without "contains" is ignored`)}};e.default=r},1163:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxItems"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} items`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:r}=t,o="maxItems"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`${n}.length ${o} ${r}`)}};e.default=r},7307:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxLength"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} characters`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:s,it:a}=t,l="maxLength"===e?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,r.useFunc)(t.gen,o.default)}(${n})`;t.fail$data(i._`${c} ${l} ${s}`)}};e.default=s},5882:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r=i.operators,o={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},s={message:({keyword:t,schemaCode:e})=>i.str`must be ${o[t].okStr} ${e}`,params:({keyword:t,schemaCode:e})=>i._`{comparison: ${o[t].okStr}, limit: ${e}}`},a={keyword:Object.keys(o),type:"number",schemaType:"number",$data:!0,error:s,code(t){const{keyword:e,data:n,schemaCode:r}=t;t.fail$data(i._`${n} ${o[e].fail} ${r} || isNaN(${n})`)}};e.default=a},4486:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:t,schemaCode:e}){const n="maxProperties"===t?"more":"fewer";return i.str`must NOT have ${n} than ${e} properties`},params:({schemaCode:t})=>i._`{limit: ${t}}`},code(t){const{keyword:e,data:n,schemaCode:r}=t,o="maxProperties"===e?i.operators.GT:i.operators.LT;t.fail$data(i._`Object.keys(${n}).length ${o} ${r}`)}};e.default=r},3439:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(9029),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:t})=>i.str`must be multiple of ${t}`,params:({schemaCode:t})=>i._`{multipleOf: ${t}}`},code(t){const{gen:e,data:n,schemaCode:r,it:o}=t,s=o.opts.multipleOfPrecision,a=e.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;t.fail$data(i._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};e.default=r},422:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:t})=>r.str`must match pattern "${t}"`,params:({schemaCode:t})=>r._`{pattern: ${t}}`},code(t){const{data:e,$data:n,schema:o,schemaCode:s,it:a}=t,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(t,o);t.fail$data(r._`!${c}.test(${e})`)}};e.default=o},4003:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:t}})=>r.str`must have required property '${t}'`,params:({params:{missingProperty:t}})=>r._`{missingProperty: ${t}}`},code(t){const{gen:e,schema:n,schemaCode:s,data:a,$data:l,it:c}=t,{opts:h}=c;if(!l&&0===n.length)return;const u=n.length>=h.loopRequired;if(c.allErrors?function(){if(u||l)t.block$data(r.nil,d);else for(const e of n)(0,i.checkReportMissingProp)(t,e)}():function(){const o=e.let("missing");if(u||l){const n=e.let("valid",!0);t.block$data(n,(()=>function(n,o){t.setParams({missingProperty:n}),e.forOf(n,s,(()=>{e.assign(o,(0,i.propertyInData)(e,a,n,h.ownProperties)),e.if((0,r.not)(o),(()=>{t.error(),e.break()}))}),r.nil)}(o,n))),t.ok(n)}else e.if((0,i.checkMissingProp)(t,n,o)),(0,i.reportMissingProp)(t,o),e.else()}(),h.strictRequired){const e=t.parentSchema.properties,{definedProperties:i}=t.it;for(const t of n)if(void 0===(null==e?void 0:e[t])&&!i.has(t)){const e=`required property "${t}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,o.checkStrictMode)(c,e,c.opts.strictRequired)}}function d(){e.forOf("prop",s,(n=>{t.setParams({missingProperty:n}),e.if((0,i.noPropertyInData)(e,a,n,h.ownProperties),(()=>t.error()))}))}}};e.default=s},617:(t,e,n)=>{"use strict";Object.defineProperty(e,"__esModule",{value:!0});const i=n(208),r=n(9029),o=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:t,j:e}})=>r.str`must NOT have duplicate items (items ## ${e} and ${t} are identical)`,params:({params:{i:t,j:e}})=>r._`{i: ${t}, j: ${e}}`},code(t){const{gen:e,data:n,$data:a,schema:l,parentSchema:c,schemaCode:h,it:u}=t;if(!a&&!l)return;const d=e.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(o,s){const a=e.name("item"),l=(0,i.checkDataTypes)(p,a,u.opts.strictNumbers,i.DataType.Wrong),c=e.const("indices",r._`{}`);e.for(r._`;${o}--;`,(()=>{e.let(a,r._`${n}[${o}]`),e.if(l,r._`continue`),p.length>1&&e.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),e.if(r._`typeof ${c}[${a}] == "number"`,(()=>{e.assign(s,r._`${c}[${a}]`),t.error(),e.assign(d,!1).break()})).code(r._`${c}[${a}] = ${o}`)}))}function f(i,a){const l=(0,o.useFunc)(e,s.default),c=e.name("outer");e.label(c).for(r._`;${i}--;`,(()=>e.for(r._`${a} = ${i}; ${a}--;`,(()=>e.if(r._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{t.error(),e.assign(d,!1).break(c)}))))))}t.block$data(d,(function(){const i=e.let("i",r._`${n}.length`),o=e.let("j");t.setParams({i,j:o}),e.assign(d,!0),e.if(r._`${i} > 1`,(()=>(p.length>0&&!p.some((t=>"object"===t||"array"===t))?m:f)(i,o)))}),r._`${h} === false`),t.ok(d)}};e.default=a},5488:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n    /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n    margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n    max-height: 250px;\n    overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n    height: inherit;\n    display: block;\n    margin-top: 1.5px;\n    margin-bottom: 1.5px;\n    margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n    display: flex;\n}"],sourceRoot:""}]);const a=s},857:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB;;AAEA;IACI,qBAAqB;AACzB;;AAEA;IACI,4BAA4B;AAChC",sourcesContent:[".monomer-manager-root .grok-sketcher {\n    min-width: unset !important;\n}\n\n.monomer-manager-root {\n    width: 100% !important;\n    height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n    height: 100% !important;\n    width: unset !important;\n} \n\n.monomer-manager-root > div:first-child {\n    flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n    flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n    max-width: unset !important;\n}\n\n.monomer-card-info-row {\n    width: 100%;\n    overflow: hidden;\n    text-overflow: ellipsis;\n    margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n    white-space: nowrap;\n    overflow: hidden;\n    text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n    font-weight: bold;\n    margin-right: 5px;\n    text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n    visibility: visible !important;\n}\n\n.monomer-card-root {\n    border: 2px solid var(--grey-2);\n    border-radius: 5px;\n    padding: 5px;\n    margin: 5px;\n    overflow: hidden;\n    align-items: center;\n    cursor: pointer;\n    width: 200px;\n    height: 300px;\n    min-width: 200px;\n    min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n    width: 100% !important;\n    overflow-x: clip;\n    overflow-y: auto;\n}\n\n.monomer-manager-form-tab-control input.d4-invalid {\n    background: #ff000030;\n}\n\n.monomer-lib-controls-form .ui-input-root {\n    flex-wrap: nowrap !important;\n}"],sourceRoot:""}]);const a=s},6369:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n    margin-bottom: 0;\n    text-align: end;\n    font-size: 12px;\n    opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n    justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,WAAW;AACf;;AAEA;IACI,4BAA4B;IAC5B,yBAAyB;IACzB,eAAe;AACnB;;AAEA;GACG,mBAAmB;AACtB;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;AAChB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n    right: 10px;\n}\n\n.cliffs_div {\n    flex-grow: initial!important;\n    justify-content: flex-end;\n    flex-wrap: wrap;\n}\n\n.cliffs_grid {\n   margin: 0!important;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n    font-size: 18px;\n    position: absolute;\n    height: 28px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n    left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n    max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n    display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n    margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n    margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n    margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n    display: flex;\n    flex-direction: row;\n    align-items: center;\n    margin-bottom: 10px !important;\n    width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n    text-overflow: ellipsis;\n    overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n    margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n    padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(t,e,n)=>{"use strict";n.d(e,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([t.id,".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,gBAAgB;EAChB,WAAW;;AAEb",sourcesContent:[".monomer-lib-controls-form {\n  margin-left: auto;\n  margin-right: auto;\n  display: flex;\n  flex-direction: column;\n  align-items: center;\n  min-width: 220px;\n  width: 100%;\n\n}\n"],sourceRoot:""}]);const a=s},6314:t=>{"use strict";t.exports=function(t){var e=[];return e.toString=function(){return this.map((function(e){var n="",i=void 0!==e[5];return e[4]&&(n+="@supports (".concat(e[4],") {")),e[2]&&(n+="@media ".concat(e[2]," {")),i&&(n+="@layer".concat(e[5].length>0?" ".concat(e[5]):""," {")),n+=t(e),i&&(n+="}"),e[2]&&(n+="}"),e[4]&&(n+="}"),n})).join("")},e.i=function(t,n,i,r,o){"string"==typeof t&&(t=[[null,t,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<t.length;c++){var h=[].concat(t[c]);i&&s[h[0]]||(void 0!==o&&(void 0===h[5]||(h[1]="@layer".concat(h[5].length>0?" ".concat(h[5]):""," {").concat(h[1],"}")),h[5]=o),n&&(h[2]?(h[1]="@media ".concat(h[2]," {").concat(h[1],"}"),h[2]=n):h[2]=n),r&&(h[4]?(h[1]="@supports (".concat(h[4],") {").concat(h[1],"}"),h[4]=r):h[4]="".concat(r)),e.push(h))}},e}},1354:t=>{"use strict";t.exports=function(t){var e=t[1],n=t[3];if(!n)return e;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),o="/*# ".concat(r," */");return[e].concat([o]).join("\n")}return[e].join("\n")}},2017:t=>{"use strict";t.exports=function t(e,n){if(e===n)return!0;if(e&&n&&"object"==typeof e&&"object"==typeof n){if(e.constructor!==n.constructor)return!1;var i,r,o;if(Array.isArray(e)){if((i=e.length)!=n.length)return!1;for(r=i;0!=r--;)if(!t(e[r],n[r]))return!1;return!0}if(e.constructor===RegExp)return e.source===n.source&&e.flags===n.flags;if(e.valueOf!==Object.prototype.valueOf)return e.valueOf()===n.valueOf();if(e.toString!==Object.prototype.toString)return e.toString()===n.toString();if((i=(o=Object.keys(e)).length)!==Object.keys(n).length)return!1;for(r=i;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,o[r]))return!1;for(r=i;0!=r--;){var s=o[r];if(!t(e[s],n[s]))return!1}return!0}return e!=e&&n!=n}},9982:function(t,e,n){var i;!function(){var e={};!function(t){"use strict";t.__esModule=!0,t.digestLength=32,t.blockSize=64;var e=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(t,n,i,r,o){for(var s,a,l,c,h,u,d,p,m,f,g,y,b;o>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],h=n[4],u=n[5],d=n[6],p=n[7],f=0;f<16;f++)g=r+4*f,t[f]=(255&i[g])<<24|(255&i[g+1])<<16|(255&i[g+2])<<8|255&i[g+3];for(f=16;f<64;f++)y=((m=t[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=t[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,t[f]=(y+t[f-7]|0)+(b+t[f-16]|0);for(f=0;f<64;f++)y=(((h>>>6|h<<26)^(h>>>11|h<<21)^(h>>>25|h<<7))+(h&u^~h&d)|0)+(p+(e[f]+t[f]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=u,u=h,h=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=h,n[5]+=u,n[6]+=d,n[7]+=p,r+=64,o-=64}return r}var i=function(){function e(){this.digestLength=t.digestLength,this.blockSize=t.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return e.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},e.prototype.clean=function(){for(var t=0;t<this.buffer.length;t++)this.buffer[t]=0;for(t=0;t<this.temp.length;t++)this.temp[t]=0;this.reset()},e.prototype.update=function(t,e){if(void 0===e&&(e=t.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=e,this.bufferLength>0){for(;this.bufferLength<64&&e>0;)this.buffer[this.bufferLength++]=t[i++],e--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(e>=64&&(i=n(this.temp,this.state,t,i,e),e%=64);e>0;)this.buffer[this.bufferLength++]=t[i++],e--;return this},e.prototype.finish=function(t){if(!this.finished){var e=this.bytesHashed,i=this.bufferLength,r=e/536870912|0,o=e<<3,s=e%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=r>>>24&255,this.buffer[s-7]=r>>>16&255,this.buffer[s-6]=r>>>8&255,this.buffer[s-5]=r>>>0&255,this.buffer[s-4]=o>>>24&255,this.buffer[s-3]=o>>>16&255,this.buffer[s-2]=o>>>8&255,this.buffer[s-1]=o>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)t[4*a+0]=this.state[a]>>>24&255,t[4*a+1]=this.state[a]>>>16&255,t[4*a+2]=this.state[a]>>>8&255,t[4*a+3]=this.state[a]>>>0&255;return this},e.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},e.prototype._saveState=function(t){for(var e=0;e<this.state.length;e++)t[e]=this.state[e]},e.prototype._restoreState=function(t,e){for(var n=0;n<this.state.length;n++)this.state[n]=t[n];this.bytesHashed=e,this.finished=!1,this.bufferLength=0},e}();t.Hash=i;var r=function(){function t(t){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var e=new Uint8Array(this.blockSize);if(t.length>this.blockSize)(new i).update(t).finish(e).clean();else for(var n=0;n<t.length;n++)e[n]=t[n];for(n=0;n<e.length;n++)e[n]^=54;for(this.inner.update(e),n=0;n<e.length;n++)e[n]^=106;for(this.outer.update(e),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<e.length;n++)e[n]=0}return t.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},t.prototype.clean=function(){for(var t=0;t<this.istate.length;t++)this.ostate[t]=this.istate[t]=0;this.inner.clean(),this.outer.clean()},t.prototype.update=function(t){return this.inner.update(t),this},t.prototype.finish=function(t){return this.outer.finished?this.outer.finish(t):(this.inner.finish(t),this.outer.update(t,this.digestLength).finish(t)),this},t.prototype.digest=function(){var t=new Uint8Array(this.digestLength);return this.finish(t),t},t}();function o(t){var e=(new i).update(t),n=e.digest();return e.clean(),n}function s(t,e){var n=new r(t).update(e),i=n.digest();return n.clean(),i}function a(t,e,n,i){var r=i[0];if(0===r)throw new Error("hkdf: cannot expand more");e.reset(),r>1&&e.update(t),n&&e.update(n),e.update(i),e.finish(t),i[0]++}t.HMAC=r,t.hash=o,t.default=o,t.hmac=s;var l=new Uint8Array(t.digestLength);t.hkdf=function(t,e,n,i){void 0===e&&(e=l),void 0===i&&(i=32);for(var o=new Uint8Array([1]),c=s(e,t),h=new r(c),u=new Uint8Array(h.digestLength),d=u.length,p=new Uint8Array(i),m=0;m<i;m++)d===u.length&&(a(u,h,n,o),d=0),p[m]=u[d++];return h.clean(),u.fill(0),o.fill(0),p},t.pbkdf2=function(t,e,n,i){for(var o=new r(t),s=o.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),h=new Uint8Array(i),u=0;u*s<i;u++){var d=u+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,o.reset(),o.update(e),o.update(a),o.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){o.reset(),o.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&u*s+p<i;p++)h[u*s+p]=l[p]}for(u=0;u<s;u++)l[u]=c[u]=0;for(u=0;u<4;u++)a[u]=0;return o.clean(),h}}(e);var r=e.default;for(var o in e)r[o]=e[o];"object"==typeof t.exports?t.exports=r:void 0===(i=function(){return r}.call(e,n,e,t))||(t.exports=i)}()},2787:(t,e,n)=>{"use strict";n.d(e,{I:()=>r});const i=new Uint32Array(65536),r=(t,e)=>{if(t.length<e.length){const n=e;e=t,t=n}return 0===e.length?t.length:t.length<=32?((t,e)=>{const n=t.length,r=e.length,o=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[t.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let t=i[e.charCodeAt(c)];const n=t|a;t|=(t&s)+s^s,a|=~(t|s),s&=t,a&o&&l++,s&o&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[t.charCodeAt(c)]=0;return l})(t,e):((t,e)=>{const n=e.length,r=t.length,o=[],s=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let t=0;t<a;t++)s[t]=-1,o[t]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const h=32*c,u=Math.min(32,r)+h;for(let e=h;e<u;e++)i[t.charCodeAt(e)]|=1<<e;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],r=s[t/32|0]>>>t&1,c=o[t/32|0]>>>t&1,h=n|a,u=((n|c)&l)+l^l|n|c;let d=a|~(u|l),p=l&u;d>>>31^r&&(s[t/32|0]^=1<<t),p>>>31^c&&(o[t/32|0]^=1<<t),d=d<<1|r,p=p<<1|c,l=p|~(h|d),a=d&h}for(let e=h;e<u;e++)i[t.charCodeAt(e)]=0}let h=0,u=-1;const d=32*c,p=Math.min(32,r-d)+d;for(let e=d;e<p;e++)i[t.charCodeAt(e)]|=1<<e;let m=r;for(let t=0;t<n;t++){const n=i[e.charCodeAt(t)],a=s[t/32|0]>>>t&1,l=o[t/32|0]>>>t&1,c=n|h,d=((n|l)&u)+u^u|n|l;let p=h|~(d|u),f=u&d;m+=p>>>r-1&1,m-=f>>>r-1&1,p>>>31^a&&(s[t/32|0]^=1<<t),f>>>31^l&&(o[t/32|0]^=1<<t),p=p<<1|a,f=f<<1|l,u=f|~(c|p),h=p&c}for(let e=d;e<p;e++)i[t.charCodeAt(e)]=0;return m})(t,e)}},9937:t=>{t.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(t,e)=>{e.assign=function(t){t=t||{};var e,n,i,r=Array.prototype.slice.call(arguments).slice(1);for(e=0,i=r.length;e<i;e++)if(r[e])for(n in r[e])t[n]=r[e][n];return t},e.validateSettings=function(t){return"linLogMode"in t&&"boolean"!=typeof t.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in t&&"boolean"!=typeof t.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in t&&"boolean"!=typeof t.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in t&&"number"!=typeof t.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in t)||"number"==typeof t.scalingRatio&&t.scalingRatio>=0?"strongGravityMode"in t&&"boolean"!=typeof t.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in t)||"number"==typeof t.gravity&&t.gravity>=0?"slowDown"in t&&!("number"==typeof t.slowDown||t.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in t&&"boolean"!=typeof t.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in t)||"number"==typeof t.barnesHutTheta&&t.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},e.graphToByteArrays=function(t,e){var n,i=t.order,r=t.size,o={},s=new Float32Array(10*i),a=new Float32Array(3*r);return n=0,t.forEachNode((function(t,e){o[t]=n,s[n]=e.x,s[n+1]=e.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=e.size||1,s[n+9]=e.fixed?1:0,n+=10})),n=0,t.forEachEdge((function(t,i,r,l,c,h,u){var d=o[r],p=o[l],m=e(t,i,r,l,c,h,u);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},e.assignLayoutChanges=function(t,e,n){var i=0;t.updateEachNodeAttributes((function(t,r){return r.x=e[i],r.y=e[i+1],i+=10,n?n(t,r):r}))},e.readGraphPositions=function(t,e){var n=0;t.forEachNode((function(t,i){e[n]=i.x,e[n+1]=i.y,n+=10}))},e.collectLayoutChanges=function(t,e,n){for(var i=t.nodes(),r={},o=0,s=0,a=e.length;o<a;o+=10){if(n){var l=Object.assign({},t.getNodeAttributes(i[s]));l.x=e[o],l.y=e[o+1],l=n(i[s],l),r[i[s]]={x:l.x,y:l.y}}else r[i[s]]={x:e[o],y:e[o+1]};s++}return r},e.createWorker=function(t){var e=window.URL||window.webkitURL,n=t.toString(),i=e.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),r=new Worker(i);return e.revokeObjectURL(i),r}},8903:(t,e,n)=>{var i=n(1736),r=n(8153).Fd,o=n(2561),s=n(1782),a=n(9937);function l(t,e,n){if(!i(e))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=r("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,h="function"==typeof n.outputReducer?n.outputReducer:null,u=s.assign({},a,n.settings),d=s.validateSettings(u);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(e,c);for(p=0;p<l;p++)o(u,m.nodes,m.edges);if(!t)return s.collectLayoutChanges(e,m.nodes);s.assignLayoutChanges(e,m.nodes,h)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(t){var e="number"==typeof t?t:t.order;return{barnesHutOptimize:e>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(e)}},t.exports=c},2561:t=>{var e=10;t.exports=function(t,n,i){var r,o,s,a,l,c,h,u,d,p,m,f,g,y,b,v,w,C,A,S,x,E,M,_=n.length,I=i.length,T=t.adjustSizes,L=t.barnesHutTheta*t.barnesHutTheta,N=[];for(s=0;s<_;s+=e)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(t.outboundAttractionDistribution){for(m=0,s=0;s<_;s+=e)m+=n[s+6];m/=_/e}if(t.barnesHutOptimize){var P,$,R,O=1/0,k=-1/0,G=1/0,F=-1/0;for(s=0;s<_;s+=e)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),G=Math.min(G,n[s+1]),F=Math.max(F,n[s+1]);var H=k-O,B=F-G;for(H>B?F=(G-=(H-B)/2)+H:k=(O-=(B-H)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+F)/2,N[3]=Math.max(k-O,F-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,r=1,s=0;s<_;s+=e)for(o=0,R=3;;){if(!(N[o+5]>=0)){if(N[o+0]<0){N[o+0]=s;break}if(N[o+5]=9*r,u=N[o+3]/2,N[(d=N[o+5])+0]=-1,N[d+1]=N[o+1]-u,N[d+2]=N[o+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]-u,N[d+2]=N[o+2]+u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+u,N[d+2]=N[o+2]-u,N[d+3]=u,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+u,N[d+2]=N[o+2]+u,N[d+3]=u,N[d+4]=N[o+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,r+=4,P=n[N[o+0]+0]<N[o+1]?n[N[o+0]+1]<N[o+2]?N[o+5]:N[o+5]+9:n[N[o+0]+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+6]=n[N[o+0]+6],N[o+7]=n[N[o+0]+0],N[o+8]=n[N[o+0]+1],N[P+0]=N[o+0],N[o+0]=-1,P===($=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27)){if(R--){o=P;continue}R=3;break}N[$+0]=s;break}P=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+7]=(N[o+7]*N[o+6]+n[s+0]*n[s+6])/(N[o+6]+n[s+6]),N[o+8]=(N[o+8]*N[o+6]+n[s+1]*n[s+6])/(N[o+6]+n[s+6]),N[o+6]+=n[s+6],o=P}}if(t.barnesHutOptimize){for(f=t.scalingRatio,s=0;s<_;s+=e)for(o=0;;)if(N[o+5]>=0){if(v=Math.pow(n[s+0]-N[o+7],2)+Math.pow(n[s+1]-N[o+8],2),4*(p=N[o+3])*p/v<L){if(g=n[s+0]-N[o+7],y=n[s+1]-N[o+8],!0===T?v>0?(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*N[o+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w),(o=N[o+4])<0)break;continue}o=N[o+5]}else if((c=N[o+0])>=0&&c!==s&&(v=(g=n[s+0]-n[c+0])*g+(y=n[s+1]-n[c+1])*y,!0===T?v>0?(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w)),(o=N[o+4])<0)break}else for(f=t.scalingRatio,a=0;a<_;a+=e)for(l=0;l<a;l+=e)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=t.gravity/t.scalingRatio,f=t.scalingRatio,s=0;s<_;s+=e)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(t.outboundAttractionDistribution?m:1),h=0;h<I;h+=3)a=i[h+0],l=i[h+1],u=i[h+2],b=Math.pow(u,t.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),t.linLogMode?t.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):t.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===T)for(s=0;s<_;s+=e)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=M);else for(s=0;s<_;s+=e)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/t.slowDown),n[s+0]=E,M=n[s+1]+n[s+3]*(x/t.slowDown),n[s+1]=M);return{}}},8153:(t,e)=>{function n(t){return"number"!=typeof t||isNaN(t)?1:t}e.Fd=function(t){return function(t,e){var n={},i=function(t){return void 0===t?e:t};"function"==typeof e&&(i=e);var r=function(e){return i(e[t])},o=function(){return i(void 0)};return"string"==typeof t?(n.fromAttributes=r,n.fromGraph=function(t,e){return r(t.getEdgeAttributes(e))},n.fromEntry=function(t,e){return r(e)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof t?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(e,n){var r=e.extremities(n);return i(t(n,e.getEdgeAttributes(n),r[0],r[1],e.getNodeAttributes(r[0]),e.getNodeAttributes(r[1]),e.isUndirected(n)))},n.fromEntry=function(e,n,r,o,s,a,l){return i(t(e,n,r,o,s,a,l))},n.fromPartialEntry=function(e,n,r,o){return i(t(e,n,r,o))},n.fromMinimalEntry=function(e,n){return i(t(e,n))}):(n.fromAttributes=o,n.fromGraph=o,n.fromEntry=o,n.fromMinimalEntry=o),n}(t,n)}},1736:t=>{t.exports=function(t){return null!==t&&"object"==typeof t&&"function"==typeof t.addUndirectedEdgeWithKey&&"function"==typeof t.dropNode&&"boolean"==typeof t.multi}},934:function(t){t.exports=function(){"use strict";function t(e){return(t="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol&&t!==Symbol.prototype?"symbol":typeof t})(e)}function e(t,e){t.prototype=Object.create(e.prototype),t.prototype.constructor=t,i(t,e)}function n(t){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(t){return t.__proto__||Object.getPrototypeOf(t)},n(t)}function i(t,e){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(t,e){return t.__proto__=e,t},i(t,e)}function r(t,e,n){return r=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(t){return!1}}()?Reflect.construct.bind():function(t,e,n){var r=[null];r.push.apply(r,e);var o=new(Function.bind.apply(t,r));return n&&i(o,n.prototype),o},r.apply(null,arguments)}function o(t){var e="function"==typeof Map?new Map:void 0;return o=function(t){if(null===t||(o=t,-1===Function.toString.call(o).indexOf("[native code]")))return t;var o;if("function"!=typeof t)throw new TypeError("Super expression must either be null or a function");if(void 0!==e){if(e.has(t))return e.get(t);e.set(t,s)}function s(){return r(t,arguments,n(this).constructor)}return s.prototype=Object.create(t.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,t)},o(t)}function s(t){if(void 0===t)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return t}var a=function(){for(var t=arguments[0],e=1,n=arguments.length;e<n;e++)if(arguments[e])for(var i in arguments[e])t[i]=arguments[e][i];return t};function l(t,e,n,i){var r=t._nodes.get(e),o=null;return r?o="mixed"===i?r.out&&r.out[n]||r.undirected&&r.undirected[n]:"directed"===i?r.out&&r.out[n]:r.undirected&&r.undirected[n]:o}function c(e){return"object"===t(e)&&null!==e}function h(t){var e;for(e in t)return!1;return!0}function u(t,e,n){Object.defineProperty(t,e,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(t,e,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(t,e,i)}function p(t){return!(!c(t)||t.attributes&&!Array.isArray(t.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(t,e,n){return Function.prototype.apply.call(t,e,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(t){return Object.getOwnPropertyNames(t).concat(Object.getOwnPropertySymbols(t))}:function(t){return Object.getOwnPropertyNames(t)};var b=Number.isNaN||function(t){return t!=t};function v(){v.init.call(this)}f.exports=v,f.exports.once=function(t,e){return new Promise((function(n,i){function r(n){t.removeListener(e,o),i(n)}function o(){"function"==typeof t.removeListener&&t.removeListener("error",r),n([].slice.call(arguments))}T(t,e,o,{once:!0}),"error"!==e&&function(t,e){"function"==typeof t.on&&T(t,"error",e,{once:!0})}(t,r)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(t){if("function"!=typeof t)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof t)}function A(t){return void 0===t._maxListeners?v.defaultMaxListeners:t._maxListeners}function S(t,e,n,i){var r,o,s,a;if(C(n),void 0===(o=t._events)?(o=t._events=Object.create(null),t._eventsCount=0):(void 0!==o.newListener&&(t.emit("newListener",e,n.listener?n.listener:n),o=t._events),s=o[e]),void 0===s)s=o[e]=n,++t._eventsCount;else if("function"==typeof s?s=o[e]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(r=A(t))>0&&s.length>r&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(e)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=t,l.type=e,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return t}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(t,e,n){var i={fired:!1,wrapFn:void 0,target:t,type:e,listener:n},r=x.bind(i);return r.listener=n,i.wrapFn=r,r}function M(t,e,n){var i=t._events;if(void 0===i)return[];var r=i[e];return void 0===r?[]:"function"==typeof r?n?[r.listener||r]:[r]:n?function(t){for(var e=new Array(t.length),n=0;n<e.length;++n)e[n]=t[n].listener||t[n];return e}(r):I(r,r.length)}function _(t){var e=this._events;if(void 0!==e){var n=e[t];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(t,e){for(var n=new Array(e),i=0;i<e;++i)n[i]=t[i];return n}function T(t,e,n,i){if("function"==typeof t.on)i.once?t.once(e,n):t.on(e,n);else{if("function"!=typeof t.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof t);t.addEventListener(e,(function r(o){i.once&&t.removeEventListener(e,r),n(o)}))}}function L(t){if("function"!=typeof t)throw new Error("obliterator/iterator: expecting a function!");this.next=t}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+t+".");w=t}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(t){if("number"!=typeof t||t<0||b(t))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+t+".");return this._maxListeners=t,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(t){for(var e=[],n=1;n<arguments.length;n++)e.push(arguments[n]);var i="error"===t,r=this._events;if(void 0!==r)i=i&&void 0===r.error;else if(!i)return!1;if(i){var o;if(e.length>0&&(o=e[0]),o instanceof Error)throw o;var s=new Error("Unhandled error."+(o?" ("+o.message+")":""));throw s.context=o,s}var a=r[t];if(void 0===a)return!1;if("function"==typeof a)y(a,this,e);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,e)}return!0},v.prototype.addListener=function(t,e){return S(this,t,e,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(t,e){return S(this,t,e,!0)},v.prototype.once=function(t,e){return C(e),this.on(t,E(this,t,e)),this},v.prototype.prependOnceListener=function(t,e){return C(e),this.prependListener(t,E(this,t,e)),this},v.prototype.removeListener=function(t,e){var n,i,r,o,s;if(C(e),void 0===(i=this._events))return this;if(void 0===(n=i[t]))return this;if(n===e||n.listener===e)0==--this._eventsCount?this._events=Object.create(null):(delete i[t],i.removeListener&&this.emit("removeListener",t,n.listener||e));else if("function"!=typeof n){for(r=-1,o=n.length-1;o>=0;o--)if(n[o]===e||n[o].listener===e){s=n[o].listener,r=o;break}if(r<0)return this;0===r?n.shift():function(t,e){for(;e+1<t.length;e++)t[e]=t[e+1];t.pop()}(n,r),1===n.length&&(i[t]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",t,s||e)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(t){var e,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[t]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[t]),this;if(0===arguments.length){var r,o=Object.keys(n);for(i=0;i<o.length;++i)"removeListener"!==(r=o[i])&&this.removeAllListeners(r);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(e=n[t]))this.removeListener(t,e);else if(void 0!==e)for(i=e.length-1;i>=0;i--)this.removeListener(t,e[i]);return this},v.prototype.listeners=function(t){return M(this,t,!0)},v.prototype.rawListeners=function(t){return M(this,t,!1)},v.listenerCount=function(t,e){return"function"==typeof t.listenerCount?t.listenerCount(e):_.call(t,e)},v.prototype.listenerCount=_,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var t=arguments,e=t.length,n=0;return new L((function(){return n>=e?{done:!0}:{done:!1,value:t[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(t){var e=0,n=t.length;return new L((function(){return e>=n?{done:!0}:{done:!1,value:t[e++]}}))},L.is=function(t){return t instanceof L||"object"==typeof t&&null!==t&&"function"==typeof t.next};var N=L,P={};P.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,P.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var $=N,R=P,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(t){var e=function(t){return"string"==typeof t||Array.isArray(t)||O&&ArrayBuffer.isView(t)?$.fromSequence(t):"object"!=typeof t||null===t?null:k&&"function"==typeof t[Symbol.iterator]?t[Symbol.iterator]():"function"==typeof t.next?t:null}(t);if(!e)throw new Error("obliterator: target is not iterable nor a valid iterator.");return e},F=G,H=function(t,e){for(var n,i=arguments.length>1?e:1/0,r=i!==1/0?new Array(i):[],o=0,s=F(t);;){if(o===i)return r;if((n=s.next()).done)return o!==e&&(r.length=o),r;r[o++]=n.value}},B=function(t){function n(e){var n;return(n=t.call(this)||this).name="GraphError",n.message=e,n}return e(n,t),n}(o(Error)),D=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B),V=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B),j=function(t){function n(e){var i;return(i=t.call(this,e)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return e(n,t),n}(B);function U(t,e){this.key=t,this.attributes=e,this.clear()}function W(t,e){this.key=t,this.attributes=e,this.clear()}function q(t,e){this.key=t,this.attributes=e,this.clear()}function z(t,e,n,i,r){this.key=e,this.attributes=r,this.undirected=t,this.source=n,this.target=i}function Y(t,e,n,i,r,o,s){var a,l,c,h;if(i=""+i,0===n){if(!(a=t._nodes.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" node in the graph.'));c=r,h=o}else if(3===n){if(r=""+r,!(l=t._edges.get(r)))throw new V("Graph.".concat(e,': could not find the "').concat(r,'" edge in the graph.'));var u=l.source.key,d=l.target.key;if(i===u)a=l.target;else{if(i!==d)throw new V("Graph.".concat(e,': the "').concat(i,'" node is not attached to the "').concat(r,'" edge (').concat(u,", ").concat(d,")."));a=l.source}c=o,h=s}else{if(!(l=t._edges.get(i)))throw new V("Graph.".concat(e,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=r,h=o}return[a,c,h]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},q.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var t="out",e="in";this.undirected&&(t=e="undirected");var n=this.source.key,i=this.target.key;this.source[t][i]=this,this.undirected&&n===i||(this.target[e][n]=this)},z.prototype.attachMulti=function(){var t="out",e="in",n=this.source.key,i=this.target.key;this.undirected&&(t=e="undirected");var r=this.source[t],o=r[i];if(void 0===o)return r[i]=this,void(this.undirected&&n===i||(this.target[e][n]=this));o.previous=this,this.next=o,r[i]=this,this.target[e][n]=this},z.prototype.detach=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][e],delete this.target[i][t]},z.prototype.detachMulti=function(){var t=this.source.key,e=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][e],delete this.target[i][t]):(this.next.previous=void 0,this.source[n][e]=this.next,this.target[i][t]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return s.attributes[a]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){return Y(this,e,n,t,i)[0].attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return s.attributes.hasOwnProperty(a)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r,o){var s=Y(this,e,n,t,i,r,o),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r,o){var s=Y(this,e,n,t,i,r,o),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new D("Graph.".concat(e,": updater should be a function."));var h=a.attributes,u=c(h[l]);return h[l]=u,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];if(!c(a))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],l=o[1];if(!c(l))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o=Y(this,e,n,t,i,r),s=o[0],a=o[1];if("function"!=typeof a)throw new D("Graph.".concat(e,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(t){return"get".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return r.attributes[i]}}},{name:function(t){return"get".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+t,o=""+arguments[1];if(!(i=l(this,r,o,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(r,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(i=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return i.attributes}}},{name:function(t){return"has".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return r.attributes.hasOwnProperty(i)}}},{name:function(t){return"set".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return o.attributes[i]=r,this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(t){return"update".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+t,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(o=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof r)throw new D("Graph.".concat(e,": updater should be a function."));return o.attributes[i]=r(o.attributes[i]),this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(t){return"remove".concat(t,"Attribute")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}return delete r.attributes[i],this.emit("edgeAttributesUpdated",{key:r.key,type:"remove",attributes:r.attributes,name:i}),this}}},{name:function(t){return"replace".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return r.attributes=i,this.emit("edgeAttributesUpdated",{key:r.key,type:"replace",attributes:r.attributes}),this}}},{name:function(t){return"merge".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if(!c(i))throw new D("Graph.".concat(e,": provided attributes are not a plain object."));return a(r.attributes,i),this.emit("edgeAttributesUpdated",{key:r.key,type:"merge",attributes:r.attributes,data:i}),this}}},{name:function(t){return"update".concat(t,"Attributes")},attacher:function(t,e,n){t.prototype[e]=function(t,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(e,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(e,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+t,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(e,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(e,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(t=""+t,!(r=this._edges.get(t)))throw new V("Graph.".concat(e,': could not find the "').concat(t,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(e,": provided updater is not a function."));return r.attributes=i(r.attributes),this.emit("edgeAttributesUpdated",{key:r.key,type:"update",attributes:r.attributes}),this}}}],X=N,J=G,Q=function(){var t=arguments,e=null,n=-1;return new X((function(){for(var i=null;;){if(null===e){if(++n>=t.length)return{done:!0};e=J(t[n])}if(!0!==(i=e.next()).done)break;e=null}return i}))},tt=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function et(t,e,n,i){var r=!1;for(var o in e)if(o!==i){var s=e[o];if(r=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),t&&r)return s.key}}function nt(t,e,n,i){var r,o,s,a=!1;for(var l in e)if(l!==i){r=e[l];do{if(o=r.source,s=r.target,a=n(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected),t&&a)return r.key;r=r.next}while(void 0!==r)}}function it(t,e){var n,i=Object.keys(t),r=i.length,o=0;return new N((function(){do{if(n)n=n.next;else{if(o>=r)return{done:!0};var s=i[o++];if(s===e){n=void 0;continue}n=t[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function rt(t,e,n,i){var r=e[n];if(r){var o=r.source,s=r.target;return i(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected)&&t?r.key:void 0}}function ot(t,e,n,i){var r=e[n];if(r){var o=!1;do{if(o=i(r.key,r.attributes,r.source.key,r.target.key,r.source.attributes,r.target.attributes,r.undirected),t&&o)return r.key;r=r.next}while(void 0!==r)}}function st(t,e){var n=t[e];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var t={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:t}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function at(t,e,n,i){if(0!==e.size)for(var r,o,s="mixed"!==n&&n!==e.type,a="undirected"===n,l=!1,c=e._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var h=o,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,o.undirected),t&&l)return u}}function lt(t,e,n,i,r,o){var s,a=e?nt:et;if("undirected"!==n){if("out"!==i&&(s=a(t,r.in,o),t&&s))return s;if("in"!==i&&(s=a(t,r.out,o,i?void 0:r.key),t&&s))return s}if("directed"!==n&&(s=a(t,r.undirected,o),t&&s))return s}function ct(t,e,n,i,r,o,s){var a,l=n?ot:rt;if("undirected"!==e){if(void 0!==r.in&&"out"!==i&&(a=l(t,r.in,o,s),t&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(t,r.out,o,s),t&&a))return a}if("directed"!==e&&void 0!==r.undirected&&(a=l(t,r.undirected,o,s),t&&a))return a}var ht=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ut(){this.A=null,this.B=null}function dt(t,e,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!e||!e.has(c.key)){var h=r(c.key,c.attributes);if(t&&h)return c.key}}}function pt(t,e,n,i,r){if("mixed"!==e){if("undirected"===e)return dt(t,null,i,i.undirected,r);if("string"==typeof n)return dt(t,null,i,i[n],r)}var o,s=new ut;if("undirected"!==e){if("out"!==n){if(o=dt(t,null,i,i.in,r),t&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=dt(t,s,i,i.out,r),t&&o)return o;s.wrap(i.out)}}if("directed"!==e&&(o=dt(t,s,i,i.undirected,r),t&&o))return o}function mt(t,e,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return t&&t.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===e?c:l,t&&t.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function ft(t,e,n,i,r){for(var o,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(e&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),t&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=r(s.key,null,s.attributes,null,null,null,null),t&&u))return null}}function gt(t){if(!c(t))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in t))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function yt(t){if(!c(t))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in t))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in t))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in t&&(!c(t.attributes)||null===t.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in t&&"boolean"!=typeof t.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ut.prototype.wrap=function(t){null===this.A?this.A=t:null===this.B&&(this.B=t)},ut.prototype.has=function(t){return null!==this.A&&t in this.A||null!==this.B&&t in this.B};var bt,vt=(bt=255&Math.floor(256*Math.random()),function(){return bt++}),wt=new Set(["directed","undirected","mixed"]),Ct=new Set(["domain","_events","_eventsCount","_maxListeners"]),At={allowSelfLoops:!0,multi:!1,type:"mixed"};function St(t,e,n){var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}function xt(t,e,n,i,r,o,s,a){if(!i&&"undirected"===t.type)throw new j("Graph.".concat(e,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new j("Graph.".concat(e,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!t.allowSelfLoops&&o===s)throw new j("Graph.".concat(e,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=t._nodes.get(o),h=t._nodes.get(s);if(!l)throw new V("Graph.".concat(e,': source node "').concat(o,'" not found.'));if(!h)throw new V("Graph.".concat(e,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=t._edgeKeyGenerator();else if(r=""+r,t._edges.has(r))throw new j("Graph.".concat(e,': the "').concat(r,'" edge already exists in the graph.'));if(!t.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(e,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,r,l,h,a);t._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,t._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,u.key=r,t.emit("edgeAdded",u),r}function Et(t,e,n,i,r,o,s,l,h){if(!i&&"undirected"===t.type)throw new j("Graph.".concat(e,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===t.type)throw new j("Graph.".concat(e,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(e,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(e,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(o=""+o,s=""+s,h&&(u=l,l=void 0),!t.allowSelfLoops&&o===s)throw new j("Graph.".concat(e,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=t._nodes.get(o),f=t._nodes.get(s);if(!n&&(d=t._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(e,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||t.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),t.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),t.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=t._edgeKeyGenerator();else if(r=""+r,t._edges.has(r))throw new j("Graph.".concat(e,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=St(t,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=St(t,s,{}),w=!0),d=new z(i,r,m,f,l),t._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,t._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,t._directedSelfLoopCount++)),t.multi?d.attachMulti():d.attach(),i?t._undirectedSize++:t._directedSize++,b.key=r,t.emit("edgeAdded",b),[r,!0,v,w]}function Mt(t,e){t._edges.delete(e.key);var n=e.source,i=e.target,r=e.attributes,o=e.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,t._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,t._directedSelfLoopCount--)),t.multi?e.detachMulti():e.detach(),o?t._undirectedSize--:t._directedSize--,t.emit("edgeDropped",{key:e.key,attributes:r,source:n.key,target:i.key,undirected:o})}var _t=function(n){function i(t){var e;if(e=n.call(this)||this,"boolean"!=typeof(t=a({},At,t)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(t.multi,'".'));if(!wt.has(t.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(t.type,'".'));if("boolean"!=typeof t.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(t.allowSelfLoops,'".'));var i="mixed"===t.type?U:"directed"===t.type?W:q;u(s(e),"NodeDataClass",i);var r="geid_"+vt()+"_",o=0;return u(s(e),"_attributes",{}),u(s(e),"_nodes",new Map),u(s(e),"_edges",new Map),u(s(e),"_directedSize",0),u(s(e),"_undirectedSize",0),u(s(e),"_directedSelfLoopCount",0),u(s(e),"_undirectedSelfLoopCount",0),u(s(e),"_edgeKeyGenerator",(function(){var t;do{t=r+o++}while(e._edges.has(t));return t})),u(s(e),"_options",t),Ct.forEach((function(t){return u(s(e),t,e[t])})),d(s(e),"order",(function(){return e._nodes.size})),d(s(e),"size",(function(){return e._edges.size})),d(s(e),"directedSize",(function(){return e._directedSize})),d(s(e),"undirectedSize",(function(){return e._undirectedSize})),d(s(e),"selfLoopCount",(function(){return e._directedSelfLoopCount+e._undirectedSelfLoopCount})),d(s(e),"directedSelfLoopCount",(function(){return e._directedSelfLoopCount})),d(s(e),"undirectedSelfLoopCount",(function(){return e._undirectedSelfLoopCount})),d(s(e),"multi",e._options.multi),d(s(e),"type",e._options.type),d(s(e),"allowSelfLoops",e._options.allowSelfLoops),d(s(e),"implementation",(function(){return"graphology"})),e}e(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(t){return this._nodes.has(""+t)},r.hasDirectedEdge=function(t,e){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){t=""+t,e=""+e;var r=this._nodes.get(t);return!!r&&r.out.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(t,e){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+t,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){t=""+t,e=""+e;var r=this._nodes.get(t);return!!r&&r.undirected.hasOwnProperty(e)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(t,e){if(1===arguments.length){var n=""+t;return this._edges.has(n)}if(2===arguments.length){t=""+t,e=""+e;var i=this._nodes.get(t);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(e)||void 0!==i.undirected&&i.undirected.hasOwnProperty(e))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(t,e){if("undirected"!==this.type){if(t=""+t,e=""+e,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.directedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(t,e){if("directed"!==this.type){if(t=""+t,e=""+e,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(t);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.undirected&&n.undirected[e]||void 0;return i?i.key:void 0}},r.edge=function(t,e){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.edge: could not find the "'.concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V('Graph.edge: could not find the "'.concat(e,'" target node in the graph.'));var i=n.out&&n.out[e]||n.undirected&&n.undirected[e]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)},r.areOutNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out},r.areInNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in},r.areUndirectedNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"directed"!==this.type&&e in n.undirected},r.areNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&(e in n.in||e in n.out)||"directed"!==this.type&&e in n.undirected},r.areInboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.in||"directed"!==this.type&&e in n.undirected},r.areOutboundNeighbors=function(t,e){t=""+t,e=""+e;var n=this._nodes.get(t);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(t,'" node in the graph.'));return"undirected"!==this.type&&e in n.out||"directed"!==this.type&&e in n.undirected},r.inDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree},r.outDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree},r.directedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegree: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree},r.undirectedDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegree: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree},r.inboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree),n},r.outboundDegree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.outDegree),n},r.degree=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degree: could not find the "'.concat(t,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=e.undirectedDegree),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree),n},r.inDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree-e.directedLoops},r.outDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.outDegree-e.directedLoops},r.directedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"undirected"===this.type?0:e.inDegree+e.outDegree-2*e.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));return"directed"===this.type?0:e.undirectedDegree-2*e.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree,i+=e.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.outDegree,i+=e.directedLoops),n-i},r.degreeWithoutSelfLoops=function(t){t=""+t;var e=this._nodes.get(t);if(!e)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(t,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=e.undirectedDegree,i+=2*e.undirectedLoops),"undirected"!==this.type&&(n+=e.inDegree+e.outDegree,i+=2*e.directedLoops),n-i},r.source=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.source: could not find the "'.concat(t,'" edge in the graph.'));return e.source.key},r.target=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.target: could not find the "'.concat(t,'" edge in the graph.'));return e.target.key},r.extremities=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.extremities: could not find the "'.concat(t,'" edge in the graph.'));return[e.source.key,e.target.key]},r.opposite=function(t,e){t=""+t,e=""+e;var n=this._edges.get(e);if(!n)throw new V('Graph.opposite: could not find the "'.concat(e,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(t===i)return r;if(t===r)return i;throw new V('Graph.opposite: the "'.concat(t,'" node is not attached to the "').concat(e,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(t,e){t=""+t,e=""+e;var n=this._edges.get(t);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(t,'" edge in the graph.'));return n.source.key===e||n.target.key===e},r.isUndirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isUndirected: could not find the "'.concat(t,'" edge in the graph.'));return e.undirected},r.isDirected=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isDirected: could not find the "'.concat(t,'" edge in the graph.'));return!e.undirected},r.isSelfLoop=function(t){t=""+t;var e=this._edges.get(t);if(!e)throw new V('Graph.isSelfLoop: could not find the "'.concat(t,'" edge in the graph.'));return e.source===e.target},r.addNode=function(t,e){var n=function(t,e,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(e=""+e,n=n||{},t._nodes.has(e))throw new j('Graph.addNode: the "'.concat(e,'" node already exist in the graph.'));var i=new t.NodeDataClass(e,n);return t._nodes.set(e,i),t.emit("nodeAdded",{key:e,attributes:n}),i}(this,t,e);return n.key},r.mergeNode=function(t,e){if(e&&!c(e))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(e,'"'));t=""+t,e=e||{};var n=this._nodes.get(t);return n?(e&&(a(n.attributes,e),this.emit("nodeAttributesUpdated",{type:"merge",key:t,attributes:n.attributes,data:e})),[t,!1]):(n=new this.NodeDataClass(t,e),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:e}),[t,!0])},r.updateNode=function(t,e){if(e&&"function"!=typeof e)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(e,'"'));t=""+t;var n=this._nodes.get(t);if(n){if(e){var i=n.attributes;n.attributes=e(i),this.emit("nodeAttributesUpdated",{type:"replace",key:t,attributes:n.attributes})}return[t,!1]}var r=e?e({}):{};return n=new this.NodeDataClass(t,r),this._nodes.set(t,n),this.emit("nodeAdded",{key:t,attributes:r}),[t,!0]},r.dropNode=function(t){t=""+t;var e,n=this._nodes.get(t);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(t,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){e=n.out[i];do{Mt(this,e),e=e.next}while(e)}for(var r in n.in){e=n.in[r];do{Mt(this,e),e=e.next}while(e)}}if("directed"!==this.type)for(var o in n.undirected){e=n.undirected[o];do{Mt(this,e),e=e.next}while(e)}this._nodes.delete(t),this.emit("nodeDropped",{key:t,attributes:n.attributes})},r.dropEdge=function(t){var e;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(e=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(t=""+t,!(e=this._edges.get(t)))throw new V('Graph.dropEdge: could not find the "'.concat(t,'" edge in the graph.'));return Mt(this,e),this},r.dropDirectedEdge=function(t,e){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t=""+t,e=""+e,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},r.dropUndirectedEdge=function(t,e){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,t,e,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(t,'" -> "').concat(e,'" edge in the graph.'));return Mt(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var t,e=this._nodes.values();!0!==(t=e.next()).done;)t.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(t){return this._attributes[t]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(t){return this._attributes.hasOwnProperty(t)},r.setAttribute=function(t,e){return this._attributes[t]=e,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},r.updateAttribute=function(t,e){if("function"!=typeof e)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[t];return this._attributes[t]=e(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:t}),this},r.removeAttribute=function(t){return delete this._attributes[t],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:t}),this},r.replaceAttributes=function(t){if(!c(t))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=t,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(t){if(!c(t))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,t),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:t}),this},r.updateAttributes=function(t){if("function"!=typeof t)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=t(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=t(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:e||null})},r.updateEachEdgeAttributes=function(t,e){if("function"!=typeof t)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(e&&!p(e))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=t(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:e||null})},r.forEachAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");ft(!1,!1,!1,this,t)},r.forEachAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!1,!0,this,t)},r.forEachAssymetricAdjacencyEntry=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");ft(!1,!0,!1,this,t)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(t){if("function"!=typeof t)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");ft(!1,!0,!0,this,t)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(t){if("function"!=typeof t)throw new D("Graph.forEachNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)},r.findNode=function(t){if("function"!=typeof t)throw new D("Graph.findNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return n.key},r.mapNodes=function(t){if("function"!=typeof t)throw new D("Graph.mapNode: expecting a callback.");for(var e,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(e=i.next()).done;)n=e.value,r[o++]=t(n.key,n.attributes);return r},r.someNode=function(t){if("function"!=typeof t)throw new D("Graph.someNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(t((n=e.value).key,n.attributes))return!0;return!1},r.everyNode=function(t){if("function"!=typeof t)throw new D("Graph.everyNode: expecting a callback.");for(var e,n,i=this._nodes.values();!0!==(e=i.next()).done;)if(!t((n=e.value).key,n.attributes))return!1;return!0},r.filterNodes=function(t){if("function"!=typeof t)throw new D("Graph.filterNodes: expecting a callback.");for(var e,n,i=this._nodes.values(),r=[];!0!==(e=i.next()).done;)t((n=e.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(t,e){if("function"!=typeof t)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=e,o=this._nodes.values();!0!==(n=o.next()).done;)r=t(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var t=this._nodes.values();return new N((function(){var e=t.next();if(e.done)return e;var n=e.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var t=this,e=new Array(this._nodes.size),n=0;this._nodes.forEach((function(t,i){e[n++]=function(t,e){var n={key:t};return h(e.attributes)||(n.attributes=a({},e.attributes)),n}(i,t)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(e,r){i[n++]=function(t,e,n){var i={key:e,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===t&&n.undirected&&(i.undirected=!0),i}(t.type,r,e)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:e,edges:i}},r.import=function(t){var e,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(t instanceof i)return t.forEachNode((function(t,e){l?a.mergeNode(t,e):a.addNode(t,e)})),t.forEachEdge((function(t,e,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(t,n,i,e):a.mergeDirectedEdgeWithKey(t,n,i,e):s?a.addUndirectedEdgeWithKey(t,n,i,e):a.addDirectedEdgeWithKey(t,n,i,e)})),this;if(!c(t))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(t.attributes){if(!c(t.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(t.attributes):this.replaceAttributes(t.attributes)}if(t.nodes){if(r=t.nodes,!Array.isArray(r))throw new D("Graph.import: invalid nodes. Expecting an array.");for(e=0,n=r.length;e<n;e++){gt(o=r[e]);var h=o,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(t.edges){var p=!1;if("undirected"===this.type&&(p=!0),r=t.edges,!Array.isArray(r))throw new D("Graph.import: invalid edges. Expecting an array.");for(e=0,n=r.length;e<n;e++){yt(s=r[e]);var m=s,f=m.source,g=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,f,g,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},r.nullCopy=function(t){var e=new i(a({},this._options,t));return e.replaceAttributes(a({},this.getAttributes())),e},r.emptyCopy=function(t){var e=this.nullCopy(t);return this._nodes.forEach((function(t,n){var i=a({},t.attributes);t=new e.NodeDataClass(n,i),e._nodes.set(n,t)})),e},r.copy=function(t){if("string"==typeof(t=t||{}).type&&t.type!==this.type&&"mixed"!==t.type)throw new j('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(t.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof t.multi&&t.multi!==this.multi&&!0!==t.multi)throw new j("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof t.allowSelfLoops&&t.allowSelfLoops!==this.allowSelfLoops&&!0!==t.allowSelfLoops)throw new j("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var e,n,i=this.emptyCopy(t),r=this._edges.values();!0!==(e=r.next()).done;)xt(i,"copy",!1,(n=e.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},r.toJSON=function(){return this.export()},r.toString=function(){return"[object Graph]"},r.inspect=function(){var e=this,n={};this._nodes.forEach((function(t,e){n[e]=t.attributes}));var i={},r={};this._edges.forEach((function(t,n){var o,s=t.undirected?"--":"->",a="",l=t.source.key,c=t.target.key;t.undirected&&l>c&&(o=l,l=c,c=o);var h="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?e.multi&&(void 0===r[h]?r[h]=0:r[h]++,a+="".concat(r[h],". ")):a+="[".concat(n,"]: "),i[a+=h]=t.attributes}));var o={};for(var s in this)this.hasOwnProperty(s)&&!Ct.has(s)&&"function"!=typeof this[s]&&"symbol"!==t(s)&&(o[s]=this[s]);return o.attributes=this._attributes,o.nodes=n,o.edges=i,u(o,"constructor",this.constructor),o},i}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(_t.prototype[Symbol.for("nodejs.util.inspect.custom")]=_t.prototype.inspect),[{name:function(t){return"".concat(t,"Edge")},generateKey:!0},{name:function(t){return"".concat(t,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(t){return"".concat(t,"EdgeWithKey")}},{name:function(t){return"".concat(t,"DirectedEdgeWithKey")},type:"directed"},{name:function(t){return"".concat(t,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(t){["add","merge","update"].forEach((function(e){var n=t.name(e),i="add"===e?xt:Et;t.generateKey?_t.prototype[n]=function(r,o,s){return i(this,n,!0,"undirected"===(t.type||this.type),null,r,o,s,"update"===e)}:_t.prototype[n]=function(r,o,s,a){return i(this,n,!1,"undirected"===(t.type||this.type),r,o,s,a,"update"===e)}}))})),function(t){K.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Node"),0),i(t,n("Source"),1),i(t,n("Target"),2),i(t,n("Opposite"),3)}))}(_t),function(t){Z.forEach((function(e){var n=e.name,i=e.attacher;i(t,n("Edge"),"mixed"),i(t,n("DirectedEdge"),"directed"),i(t,n("UndirectedEdge"),"undirected")}))}(_t),function(t){tt.forEach((function(e){!function(t,e){var n=e.name,i=e.type,r=e.direction;t.prototype[n]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(t,e){if(0===t.size)return[];if("mixed"===e||e===t.type)return"function"==typeof Array.from?Array.from(t._edges.keys()):H(t._edges.keys(),t._edges.size);for(var n,i,r="undirected"===e?t.undirectedSize:t.directedSize,o=new Array(r),s="undirected"===e,a=t._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(o[l++]=i.key);return o}(this,i);if(1===arguments.length){t=""+t;var o=this._nodes.get(t);if(void 0===o)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n,i){var r=[];return lt(!1,t,e,n,i,(function(t){r.push(t)})),r}(this.multi,"mixed"===i?this.type:i,r,o)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(n,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(n,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i,r){var o=[];return ct(!1,t,e,n,i,r,(function(t){o.push(t)})),o}(i,this.multi,r,s,e)}throw new D("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return at(!1,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return lt(!1,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!1,i,this.multi,r,a,e,n)}throw new D("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(){var t,e=Array.prototype.slice.call(arguments),n=e.pop();if(0===e.length){var r=0;"directed"!==i&&(r+=this.undirectedSize),"undirected"!==i&&(r+=this.directedSize),t=new Array(r);var s=0;e.push((function(e,i,r,o,a,l,c){t[s++]=n(e,i,r,o,a,l,c)}))}else t=[],e.push((function(e,i,r,o,s,a,l){t.push(n(e,i,r,o,s,a,l))}));return this[o].apply(this,e),t};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop(),n=[];return t.push((function(t,i,r,o,s,a,l){e(t,i,r,o,s,a,l)&&n.push(t)})),this[o].apply(this,t),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(){var t,e,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new D("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(t=n[0],e=n[1],n=[]):3===n.length?(t=n[1],e=n[2],n=[n[0]]):4===n.length&&(t=n[2],e=n[3],n=[n[0],n[1]]);var i=e;return n.push((function(e,n,r,o,s,a,l){i=t(i,e,n,r,o,s,a,l)})),this[o].apply(this,n),i}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="find"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return at(!0,this,i,n=t);if(2===arguments.length){t=""+t,n=e;var s=this._nodes.get(t);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return lt(!0,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){t=""+t,e=""+e;var a=this._nodes.get(t);if(!a)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return ct(!0,i,this.multi,r,a,e,n)}throw new D("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[s]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,r,o,s,a){return e(t,n,i,r,o,s,a)})),!!this[o].apply(this,t)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[a]=function(){var t=Array.prototype.slice.call(arguments),e=t.pop();return t.push((function(t,n,i,r,o,s,a){return!e(t,n,i,r,o,s,a)})),!this[o].apply(this,t)}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n.slice(0,-1)+"Entries";t.prototype[o]=function(t,e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(t,e){if(0===t.size)return N.empty();var n="mixed"!==e&&e!==t.type,i="undirected"===e,r=t._edges.values();return new N((function(){for(var t,e;;){if((t=r.next()).done)return t;if(e=t.value,!n||e.undirected===i)break}return{value:{edge:e.key,attributes:e.attributes,source:e.source.key,target:e.target.key,sourceAttributes:e.source.attributes,targetAttributes:e.target.attributes,undirected:e.undirected},done:!1}}))}(this,i);if(1===arguments.length){t=""+t;var n=this._nodes.get(t);if(!n)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){var i=N.empty();return"undirected"!==t&&("out"!==e&&void 0!==n.in&&(i=Q(i,it(n.in))),"in"!==e&&void 0!==n.out&&(i=Q(i,it(n.out,e?void 0:n.key)))),"directed"!==t&&void 0!==n.undirected&&(i=Q(i,it(n.undirected))),i}(i,r,n)}if(2===arguments.length){t=""+t,e=""+e;var s=this._nodes.get(t);if(!s)throw new V("Graph.".concat(o,':  could not find the "').concat(t,'" source node in the graph.'));if(!this._nodes.has(e))throw new V("Graph.".concat(o,':  could not find the "').concat(e,'" target node in the graph.'));return function(t,e,n,i){var r=N.empty();return"undirected"!==t&&(void 0!==n.in&&"out"!==e&&i in n.in&&(r=Q(r,st(n.in,i))),void 0!==n.out&&"in"!==e&&i in n.out&&(e||n.key!==i)&&(r=Q(r,st(n.out,i)))),"directed"!==t&&void 0!==n.undirected&&i in n.undirected&&(r=Q(r,st(n.undirected,i))),r}(i,r,s,e)}throw new D("Graph.".concat(o,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(t,e)}))}(_t),function(t){ht.forEach((function(e){(function(t,e){var n=e.name,i=e.type,r=e.direction;t.prototype[n]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(n,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return Object.keys(n.undirected);if("string"==typeof e)return Object.keys(n[e])}var i=[];return pt(!1,t,e,n,(function(t){i.push(t)})),i}("mixed"===i?this.type:i,r,e)}})(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);t.prototype[o]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));pt(!1,"mixed"===i?this.type:i,r,n,e)}};var s="map"+n[0].toUpperCase()+n.slice(1);t.prototype[s]=function(t,e){var n=[];return this[o](t,(function(t,i){n.push(e(t,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);t.prototype[a]=function(t,e){var n=[];return this[o](t,(function(t,i){e(t,i)&&n.push(t)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);t.prototype[l]=function(t,e,n){if(arguments.length<3)throw new D("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[o](t,(function(t,n){i=e(i,t,n)})),i}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n[0].toUpperCase()+n.slice(1,-1),s="find"+o;t.prototype[s]=function(t,e){if("mixed"===i||"mixed"===this.type||i===this.type){t=""+t;var n=this._nodes.get(t);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(t,'" node in the graph.'));return pt(!0,"mixed"===i?this.type:i,r,n,e)}};var a="some"+o;t.prototype[a]=function(t,e){return!!this[s](t,e)};var l="every"+o;t.prototype[l]=function(t,e){return!this[s](t,(function(t,n){return!e(t,n)}))}}(t,e),function(t,e){var n=e.name,i=e.type,r=e.direction,o=n.slice(0,-1)+"Entries";t.prototype[o]=function(t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();t=""+t;var e=this._nodes.get(t);if(void 0===e)throw new V("Graph.".concat(o,': could not find the "').concat(t,'" node in the graph.'));return function(t,e,n){if("mixed"!==t){if("undirected"===t)return mt(null,n,n.undirected);if("string"==typeof e)return mt(null,n,n[e])}var i=N.empty(),r=new ut;return"undirected"!==t&&("out"!==e&&(i=Q(i,mt(r,n,n.in))),"in"!==e&&(i=Q(i,mt(r,n,n.out)))),"directed"!==t&&(i=Q(i,mt(r,n,n.undirected))),i}("mixed"===i?this.type:i,r,e)}}(t,e)}))}(_t);var It=function(t){function n(e){var n=a({type:"directed"},e);if("multi"in n&&!1!==n.multi)throw new D("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new D('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Tt=function(t){function n(e){var n=a({type:"undirected"},e);if("multi"in n&&!1!==n.multi)throw new D("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new D('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Lt=function(t){function n(e){var n=a({multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return t.call(this,n)||this}return e(n,t),n}(_t),Nt=function(t){function n(e){var n=a({type:"directed",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new D('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t),Pt=function(t){function n(e){var n=a({type:"undirected",multi:!0},e);if("multi"in n&&!0!==n.multi)throw new D("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new D('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return t.call(this,n)||this}return e(n,t),n}(_t);function $t(t){t.from=function(e,n){var i=a({},e.options,n),r=new t(i);return r.import(e),r}}return $t(_t),$t(It),$t(Tt),$t(Lt),$t(Nt),$t(Pt),_t.Graph=_t,_t.DirectedGraph=It,_t.UndirectedGraph=Tt,_t.MultiGraph=Lt,_t.MultiDirectedGraph=Nt,_t.MultiUndirectedGraph=Pt,_t.InvalidArgumentsGraphError=D,_t.NotFoundGraphError=V,_t.UsageGraphError=j,_t}()},944:(t,e)=>{"use strict";e.Vb=void 0,e.Vb=function(t,e,n){var i=function(t,e,n){if(0===t.length||0===e.length)return 0;if(n&&!n.caseSensitive&&(t=t.toUpperCase(),e=e.toUpperCase()),t===e)return 1;for(var i=0,r=t.length,o=e.length,s=Math.floor(Math.max(r,o)/2)-1,a=new Array(r),l=new Array(o),c=0;c<r;c++)for(var h=Math.max(0,c-s);h<=Math.min(o,c+s+1);h++)if(!a[c]&&!l[h]&&t[c]===e[h]){++i,a[c]=l[h]=!0;break}if(0===i)return 0;var u=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;t.charAt(c)!==e.charAt(d++)&&u++}return(i/r+i/o+(i-(u/=2))/i)/3}(t,e,n),r=0;if(i>.7){for(var o=Math.min(t.length,e.length),s=0;t[s]===e[s]&&s<4&&s<o;)++r,s++;i+=.1*r*(1-i)}return i}},7106:t=>{"use strict";var e=t.exports=function(t,e,i){"function"==typeof e&&(i=e,e={}),n(e,"function"==typeof(i=e.cb||i)?i:i.pre||function(){},i.post||function(){},t,"",t)};function n(t,i,r,o,s,a,l,c,h,u){if(o&&"object"==typeof o&&!Array.isArray(o)){for(var d in i(o,s,a,l,c,h,u),o){var p=o[d];if(Array.isArray(p)){if(d in e.arrayKeywords)for(var m=0;m<p.length;m++)n(t,i,r,p[m],s+"/"+d+"/"+m,a,s,d,o,m)}else if(d in e.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(t,i,r,p[f],s+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,o,f)}else(d in e.keywords||t.allKeys&&!(d in e.skipKeywords))&&n(t,i,r,p,s+"/"+d,a,s,d,o)}r(o,s,a,l,c,h,u)}}e.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},e.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},e.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},e.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:t=>{"use strict";var e=[];function n(t){for(var n=-1,i=0;i<e.length;i++)if(e[i].identifier===t){n=i;break}return n}function i(t,i){for(var o={},s=[],a=0;a<t.length;a++){var l=t[a],c=i.base?l[0]+i.base:l[0],h=o[c]||0,u="".concat(c," ").concat(h);o[c]=h+1;var d=n(u),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)e[d].references++,e[d].updater(p);else{var m=r(p,i);i.byIndex=a,e.splice(a,0,{identifier:u,updater:m,references:1})}s.push(u)}return s}function r(t,e){var n=e.domAPI(e);return n.update(t),function(e){if(e){if(e.css===t.css&&e.media===t.media&&e.sourceMap===t.sourceMap&&e.supports===t.supports&&e.layer===t.layer)return;n.update(t=e)}else n.remove()}}t.exports=function(t,r){var o=i(t=t||[],r=r||{});return function(t){t=t||[];for(var s=0;s<o.length;s++){var a=n(o[s]);e[a].references--}for(var l=i(t,r),c=0;c<o.length;c++){var h=n(o[c]);0===e[h].references&&(e[h].updater(),e.splice(h,1))}o=l}}},7659:t=>{"use strict";var e={};t.exports=function(t,n){var i=function(t){if(void 0===e[t]){var n=document.querySelector(t);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(t){n=null}e[t]=n}return e[t]}(t);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:t=>{"use strict";t.exports=function(t){var e=document.createElement("style");return t.setAttributes(e,t.attributes),t.insert(e,t.options),e}},5056:(t,e,n)=>{"use strict";t.exports=function(t){var e=n.nc;e&&t.setAttribute("nonce",e)}},7825:t=>{"use strict";t.exports=function(t){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var e=t.insertStyleElement(t);return{update:function(n){!function(t,e,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,r&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var o=n.sourceMap;o&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(o))))," */")),e.styleTagTransform(i,t,e.options)}(e,t,n)},remove:function(){!function(t){if(null===t.parentNode)return!1;t.parentNode.removeChild(t)}(e)}}}},1113:t=>{"use strict";t.exports=function(t,e){if(e.styleSheet)e.styleSheet.cssText=t;else{for(;e.firstChild;)e.removeChild(e.firstChild);e.appendChild(document.createTextNode(t))}}},1407:(t,e,n)=>{"use strict";n.d(e,{R:()=>a});var i=n(4328),r=n(6082),o=n(439);const s=31;async function a(t,e,n=!1,o){const a=e.getSeqHandler(t);let c;o??=new Map;const h=a.isHelm()?e.getSeqMonomers(t):Object.keys(a.stats.freq).filter((t=>""!==t));for(let t=0;t<h.length;t++)o.has(h[t])||o.set(h[t],`${o.size+1}`);if(a.isHelm())c=await i.functions.call("HELM:getMolFiles",{col:t}),c=function(t,e,n=!1){const i=new Array(t.length);for(let r=0;r<t.length;r++){let o=0,a=0,l="\n    Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";const c=t.get(r);o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1;const h=parseInt(c.substring(o,o+3)),u=parseInt(c.substring(o+3,o+6));l+=`M  V30 COUNTS ${h} ${u} 0 0 0\n`,l+="M  V30 BEGIN ATOM\n";for(let t=0;t<h;t++){o=c.indexOf("\n",o)+1+s,a=c.indexOf(" ",o);const i=c.substring(o,a);l+=n?`M  V30 ${t+1} R${e.get(i)} 0.000 0.000 0 0\n`:`M  V30 ${t+1} At 0.000 0.000 0 0 MASS=${e.get(i)}\n`}l+="M  V30 END ATOM\n",l+="M  V30 BEGIN BOND\n";for(let t=0;t<u;t++){o=c.indexOf("\n",o)+1;const e=parseInt(c.substring(o,o+3).trim()),n=parseInt(c.substring(o+3,o+6).trim());l+=`M  V30 ${t+1} ${parseInt(c.substring(o+6,o+9).trim())} ${e} ${n}\n`}l+="M  V30 END BOND\n",l+="M  V30 END CTAB\n",l+="M  END",i[r]=l}return i}(c,o,n);else{c=new Array(t.length);for(let e=0;e<t.length;e++){const t=l(a.getSplitted(e),o,n);c[e]=t}}return r.Column.fromStrings("monomericMols",c)}function l(t,e,n=!1){let i="\n  Datagrok macromolecule handler\n\n  0  0  0  0  0  0            999 V3000\nM  V30 BEGIN CTAB\n";i+=`M  V30 COUNTS ${t.length} ${t.length?t.length-1:0} 0 0 0\n`,i+="M  V30 BEGIN ATOM\n";for(let r=0;r<t.length;r++){const s=t.getCanonical(r);s!==o._S&&(i+=n?`M  V30 ${r+1} R${e.get(s)} 0.000 0.000 0 0\n`:`M  V30 ${r+1} At 0.000 0.000 0 0 MASS=${e.get(s)}\n`)}i+="M  V30 END ATOM\n",i+="M  V30 BEGIN BOND\n";for(let e=0;e<t.length-1;e++)i+=`M  V30 ${e+1} 1 ${e+1} ${e+2}\n`;return i+="M  V30 END BOND\n",i+="M  V30 END CTAB\n",i+="M  END",i}},6766:(t,e,n)=>{"use strict";n.r(e),n.d(e,{GetRegionEditor:()=>Xi,SeqActivityCliffsEditor:()=>tr,SeqPaletteCustom:()=>ji,SequenceSpaceEditor:()=>Qi,SplitToMonomersEditor:()=>Ji,SubsequenceSearchTopMenu:()=>Or,_package:()=>Di,activityCliffs:()=>dr,addCopyMenu:()=>Qr,alignSequences:()=>wr,bioSubstructureFilter:()=>Ur,bioSubstructureFilterTest:()=>Wr,compositionAnalysis:()=>Cr,compositionAnalysisWidget:()=>or,convertColumnAction:()=>Er,convertDialog:()=>xr,customSequenceCellRenderer:()=>er,demoBioActivityCliffs:()=>no,demoBioAtomicLevel:()=>io,demoBioSequenceSpace:()=>eo,demoBioSimilarityDiversity:()=>to,detectMacromoleculeProbe:()=>ao,diversitySearchTopMenu:()=>$r,diversitySearchViewer:()=>Pr,fastaSequenceCellRenderer:()=>nr,getBioLib:()=>zi,getHelmMonomers:()=>Tr,getMolFromHelm:()=>co,getMonomerLibHelper:()=>Vi,getRegion:()=>hr,getRegionApp:()=>Yr,getRegionHelmApp:()=>Kr,getRegionPanel:()=>Ki,getRegionTopMenu:()=>ur,getSeqHandler:()=>Yi,getSeqHelper:()=>lo,helmPreprocessingFunction:()=>mr,importBam:()=>Sr,importFasta:()=>Ar,initBio:()=>Wi,libraryPanel:()=>Zi,longSeqTableFasta:()=>Xr,longSeqTableHelm:()=>Jr,longSeqTableSeparator:()=>Zr,macroMolColumnPropertyPanel:()=>rr,macromoleculeDifferenceCellRenderer:()=>sr,macromoleculePreprocessingFunction:()=>pr,manageLibrariesApp:()=>Dr,manageLibrariesAppTreeBrowser:()=>Vr,manageLibrariesView:()=>Hr,manageMonomerLibraries:()=>Fr,manageMonomersView:()=>Br,monomerCellRenderer:()=>Mr,multipleSequenceAlignmentDialog:()=>vr,saveAsFasta:()=>jr,sdfToJsonLib:()=>ro,searchSubsequenceEditor:()=>Rr,separatorSequenceCellRenderer:()=>ir,seq2atomic:()=>oo,seqIdentity:()=>so,sequenceAlignment:()=>ar,sequenceIdentityScoring:()=>kr,sequenceSimilarityScoring:()=>Gr,sequenceSpaceTopMenu:()=>fr,sequenceTooltip:()=>qi,similaritySearchTopMenu:()=>Nr,similaritySearchViewer:()=>Lr,splitToMonomersTopMenu:()=>Ir,test1:()=>ho,testDetectMacromolecule:()=>_r,toAtomicLevel:()=>gr,toAtomicLevelAction:()=>yr,toAtomicLevelPanel:()=>br,vdRegionsViewer:()=>cr,webLogoAggApp:()=>zr,webLogoLargeApp:()=>qr,webLogoViewer:()=>lr});var i,r,o=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(r=i||(i={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var h=n(1858),u=n(5072),d=n.n(u),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),A=n.n(C),S=n(7939),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(S.A,x),S.A&&S.A.locals&&S.A.locals;var E=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};let M=null,_=null;function I(t,e){return t&&""!=t?t:e}n(2780);class T{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n    the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n  used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter(),null==M))return null;let t=null;return"info"in M&&(t=M.info),t?I(t.description,I(t.vendor,"No GPU description available")):"No GPU description available"}))}().then((t=>{t?(this.useWebGPU.tooltip+=` (${t})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class P{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class ${get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((n=>{null!=t[n].value&&(e[n]=t[n].value)})),e}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(t={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new T,[c.c.T_SNE]:new L},this.dbScanParams=new P,this.editorSettings=t,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((t=>{const e=t.options.get(l.n3)??"",n=t.friendlyName??t.name,i=t.options.get(l.C0)??"",r=t.options.get(l._X)??"",o=t.options.get(l.Gi)??"";this.editorSettings.semtype&&!e.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:t,semTypes:e?e.split(","):[],types:i?i.split(","):[],units:r?r.split(","):[],distanceFunctions:o?o.split(","):[]})})),this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let e=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:t=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[t])}}),this.methodSettingsIcon=s.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let h=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{h?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),h=!h}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const t=this.tableInput.value?.columns.toList().find((t=>!!this.columnFunctionsMap[t.name]))??null,e=s.input.column("Column",{table:this.tableInput.value,value:t,onValueChanged:()=>this.onColumnInputChanged(),filter:t=>!!this.columnFunctionsMap[t.name]});return this.colInputRoot||(this.colInputRoot=e.root),e}regenerateColInput(){let t=!1;this.colInputRoot&&(t=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),t&&Array.from(this.colInput.root.children).forEach((t=>this.colInputRoot.append(t))),this.onColumnInputChanged()}onTableInputChanged(){const t=this.tableInput.value;t&&(this.columnFunctionsMap={},t.columns.toList().forEach((t=>{Object.keys(this.supportedFunctions).forEach((e=>{const n=this.supportedFunctions[e].semTypes,i=this.supportedFunctions[e].types,r=this.supportedFunctions[e].units,o=!n.length||t.semType&&n.includes(t.semType),s=!i.length||i.includes(t.type),a=!r.length||t.meta.units&&r.includes(t.meta.units);o&&s&&a&&(this.columnFunctionsMap[t.name]||(this.columnFunctionsMap[t.name]=[]),this.columnFunctionsMap[t.name].push(e))}))})),this.regenerateColInput())}onColumnInputChanged(){const t=this.colInput.value;if(!t)return;const e=this.columnFunctionsMap[t.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:e[0],items:e,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((t=>this.preprocessingFunctionInputRoot.append(t)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const t=this.preprocessingFunctionInput.value,e=this.supportedFunctions[t].distanceFunctions;this.availableMetrics=[...e],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((t=>this.similarityMetricInputRoot.append(t))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[t].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(t,e){return s.empty(t),Object.keys(e).forEach((n=>{const i=e[n],r="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:t=>{i.value=t}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:t=>{i.value=t}}):s.input.float(i.uiName,{value:i.value,onValueChanged:t=>{i.value=t}});t.append(r.root),i.disable?(r.enabled=!1,s.tooltip.bind(r.input??r.root,i.disableTooltip??"")):s.tooltip.bind(r.input??r.root,i.tooltip)})),t}async createPreprocessingFuncParamsDiv(t,e){if(s.empty(t),e.inputs.length<3)return s.div();const n=e.prepare(),i=await n.buildEditor(s.div());for(let r=2;r<e.inputs.length;r++){const o=e.inputs[r];(this.preprocessingFunctionSettings[o.name]||n.inputParams[e.inputs[r].name].value||o.defaultValue)&&(this.preprocessingFunctionSettings[o.name]=this.preprocessingFunctionSettings[o.name]??n.inputParams[o.name].value??o.defaultValue);const s=i.find((t=>t.property.name===o.name));s&&(null!==this.preprocessingFunctionSettings[o.name]&&void 0!==this.preprocessingFunctionSettings[o.name]&&(s.value=this.preprocessingFunctionSettings[o.name]),s.onChanged.subscribe((t=>{this.preprocessingFunctionSettings[o.name]=t})),t.append(s.root))}return t}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(t){try{const e=JSON.parse(t);await this.applyInput(e)}catch(t){o.shell.error("Error applying input from history"),console.error(t)}}async applyInput(t){try{const e=this.tableInput.value?.col(t.col);if(!e)throw new Error("Column not found");this.colInput.value=e,this.preprocessingFunctionInput.value=t.preprocessingFunction,this.similarityMetricInput.value=t.similarityMetric,this.plotEmbeddingsInput.value=t.plotEmbeddings,this.clusterEmbeddingsInput.value=t.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((e=>{null!=t.options[e]&&(this.methodsParams[t.methodName][e].value=t.options[e])})),this.methodInput.value=t.methodName,this.preprocessingFunctionSettings=t.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(t){o.shell.error("Error applying input from history"),console.error(t)}}}var R=n(9713),O=n(6295);const k=t=>null==t;function G(t,e,n,i){if(n>t[t.length-1])return;const r=t.findIndex((t=>n<t));t.pop(),t.splice(r,0,n),e.pop(),e.splice(r,0,i)}class F{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=e}async calc(t,e,n=!0,r){return await this.calcMulti([t],[e],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(t,e,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(t.length<1)throw new Error("values must contain at least one array");if(e.length!==t.length||r.length!==t.length||o.length!==t.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=t[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:t,fnNames:e,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((t,e)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?e(r):(u.set(o,i),s<m&&(m=s),a>f&&(f=a),t())}}))}await Promise.all(l),n&&u.forEach(((t,e)=>{u[e]=(t-m)/(f-m)})),i(u)}catch(t){a(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}class H{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(t,e=1e6){const n=200,i=new Uint32Array(n),r=t.distance.length,o=t.distance;for(let t=0;t<r;t++)i[Math.floor(o[t]*n)]++;let s=0,a=0;for(let t=0;t<n&&(s+=i[t],a=t,!(s>=e));t++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=t.i,d=t.j;let p=0;const m=(a+1)/n;for(let t=0;t<r;t++)o[t]<m&&(l[p]=u[t],c[p]=d[t],h[p]=o[t],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(t,e,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=t[0].length>2e4?await this.getMinimalThreshold(t,e,o,s,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),o.forEach(((t,e)=>o[e].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:t,startIdx:u,endIdx:p,threshold:r,fnNames:e,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:t,i:e,j:r,distance:o}})=>{t?(d[n].terminate(),h(t)):(d[n].terminate(),i({i:e,j:r,distance:o,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((t,e)=>t+e.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const t of p)f.set(t.i,b),g.set(t.j,b),y.set(t.distance,b),b+=t.i.length;return{i:f,j:g,distance:y}}async calc(t,e,n,i={}){return await this.calcMultiColumn([t],[e],n,[i],[1])}async getKNN(t,e,n=15,i={}){return await this.multiColumnKNN([t],[e],n,[i],[1])}async getThresholdKNN(t,e,n=.8,i={}){return await this.multiColumnThresholdKnn([t],[e],n,[i],[1])}async multiColumnThresholdKnn(t,e,r=.8,o,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==o.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:o,threshold:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:r}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:r}))}}));const d=await Promise.all(h),p=new Int32Array(t[0].length);for(const e of d)for(let n=0;n<t[0].length;++n)p[n]+=e.knnIndexes[n]?.length??0;const m={knnDistances:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e]))),knnIndexes:new Array(t[0].length).fill(null).map(((t,e)=>new Array(p[e])))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)m.knnDistances[n][p[n]-1]=e.knnDistances[n][t],m.knnIndexes[n][p[n]-1]=e.knnIndexes[n][t],p[n]-=1;return m}async multiColumnSingleValueKNN(t,e,r,o=15,s,a,l=i.EUCLIDEAN){if(t.length!==r.length||t.length!==s.length||t.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=t[0].length,d=t.map((t=>t[e])),p=Math.ceil(u/this._workerCount);for(let e=0;e<this._workerCount;e++)h[e]=new Promise(((n,i)=>{const h=e*p,m=e===this._workerCount-1?u:(e+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[e].postMessage({values:t.map((t=>t.slice(h,m))),target:d,fnNames:r,opts:s,nNeighbours:o,weights:a,aggregationMethod:l,startIdx:h}),c[e].onmessage=({data:{error:t,knnDistances:r,knnIndexes:o}})=>{t?(c[e].terminate(),i(t)):(c[e].terminate(),n({knnDistances:r,knnIndexes:o}))}}));const m=await Promise.all(h),f={knnDistances:new Array(o).fill(99999),knnIndexes:new Array(o).fill(-1)};for(const t of m)for(let e=0;e<(t.knnDistances?.length??0);++e)G(f.knnDistances,f.knnIndexes,t.knnDistances[e],t.knnIndexes[e]);return f}async multiColumnKNN(t,e,r=15,o,s,a=i.EUCLIDEAN){if(t.length!==e.length||t.length!==o.length||t.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(t.some((e=>e.length!==t[0].length)))throw new Error("all values arrays should have the same length");const l=t[0].length*(t[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:t,startIdx:d,endIdx:p,fnNames:e,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:t,knnDistances:e,knnIndexes:r}})=>{t?(u[n].terminate(),h(t)):(u[n].terminate(),i({knnDistances:e,knnIndexes:r}))}}));const d=await Promise.all(h),p={knnDistances:new Array(t[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(t[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const e of d)for(let n=0;n<t[0].length;++n)for(let t=0;t<(e.knnDistances[n]?.length??0);++t)G(p.knnDistances[n],p.knnIndexes[n],e.knnDistances[n][t],e.knnIndexes[n][t]);return p}async getSampleDistances(t,e,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=t[0].length*(t[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:t,startIdx:d,endIdx:p,sampleLength:h,fnNames:e,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:t,distance:e}})=>{a[l].terminate(),t?u(t):c({distance:e})}}));const d=await Promise.all(u),p=d.reduce(((t,e)=>t+e.distance.length),0),m=new Float32Array(p);let f=0;for(const t of d)m.set(t.distance,f),f+=t.distance.length;return m.sort(),m}catch(t){return a?.forEach((t=>t?.terminate())),console.error(t),new Float32Array(1).fill(.5)}}async getMinimalThreshold(t,e,n=[],r,o=i.EUCLIDEAN){try{const i=t.length*(t.length-1)/2,s=await this.getSampleDistances(t,e,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(t){return console.error(t),.5}}static calcSync(t,e,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const h=t.length*(t.length-1)/2;for(;a<h;){const e=k(t[l])||k(t[c])?1:n(t[l],t[c]);1-e>=i&&(r.push(l),o.push(c),s.push(e)),a++,c++,c===t.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,D,V=n(8774);(D=B||(B={})).none="none",D.bold="bold",D.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(t){t!==this._currentLineIdx&&(this._currentLineIdx=t,this.sp.render(this.ctx))}set linesToRender(t){this.updateLines(t),this.sp.render(this.ctx)}set linesVisibility(t){this.visibility=t,this.sp.render(this.ctx)}constructor(t,e,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=t,this.xAxisCol=this.sp.dataFrame.columns.byName(e),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=t=>{var e;(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(t.offsetX,t.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},this.canvas.onmousemove=t=>{var e;this.mouseOverLineId=(null===(e=this.lines)||void 0===e?void 0:e.skipMouseOverDetection)?-1:this.checkCoordsOnLine(t.offsetX,t.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:t.clientX,y:t.clientY,id:this.mouseOverLineId,event:t})},t.onEvent("d4-before-draw-scene").subscribe((t=>{this.renderLines()}))}updateLines(t){this.lines=t,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),t.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var t,e,n,i,r,o,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(t=this.lines.width)&&void 0!==t?t:1,this.ctx.strokeStyle=`rgba(${null!==(e=this.lines.color)&&void 0!==e?e:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let t=0;t<this.lines.from.length;t++)if(b.get(this.lines.from[t])&&b.get(this.lines.to[t])&&this.visibility.getBit(t)){let e=0;const n=this.sp.getMarkerSize(this.lines.from[t])/2,i=this.sp.getMarkerSize(this.lines.to[t])/2,b=this.sp.pointToScreen(this.lines.from[t]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[t]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const e=(null===(r=this.lines.colors)||void 0===r?void 0:r[t])?null===(o=this.lines.colors)||void 0===o?void 0:o[t]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[t])?null===(l=this.lines.opacities)||void 0===l?void 0:l[t]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${e},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[t])?null===(u=this.lines.widths)||void 0===u?void 0:u[t]:null!==(d=this.lines.width)&&void 0!==d?d:1}t===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[t];let A=null;if(b){e=this.getLineLength(w,C,S,x);const r=this.getPointOnDistance(w,C,S,x,i,e),o=this.getPointOnDistance(S,x,w,C,n,e);w=r.x,C=r.y,S=o.x,x=o.y,A=this.lines.from[t]>this.lines.to[t]?this.findControlPoint(b,w,C,S,x,t):this.findControlPoint(b,S,x,w,C,t),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(t))&&(e||(e=this.getLineLength(w,C,S,x)),e>this.arrowWidth)){const t=b?null:this.getPointOnDistance(w,C,S,x,i,e),n=b?A.x:w,r=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==t?void 0:t.x)&&void 0!==f?f:w,null!==(g=null==t?void 0:t.y)&&void 0!==g?g:C,n,r)}this.ctx.stroke(),this.ctx.closePath(),t===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(t){switch(this.currentLineStyle){case B.bold:t?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:t?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const t=new Path2D;t.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(t),this.ctx.closePath()}createMultiLinesIndices(){const t={};for(let e=0;e<this.lines.from.length;e++){let n=0,i=0;this.lines.from[e]<this.lines.to[e]?(n=this.lines.from[e],i=this.lines.to[e]):(n=this.lines.to[e],i=this.lines.from[e]),t[`${n}|${i}`]?(1===t[`${n}|${i}`].length&&(this.multipleLinesCounts[t[`${n}|${i}`][0]]=1,t[`${n}|${i}`].push(1)),this.multipleLinesCounts[e]=++t[`${n}|${i}`][1]):t[`${n}|${i}`]=[e]}}checkCoordsOnLine(t,e){let n=-1,i=null,r=null;const o=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(o.get(this.lines.from[s])&&o.get(this.lines.to[s])&&this.visibility.getBit(s)){const o=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,o,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);r=this.calculateDistToCurveLine(s,t,e,i,h,u)}else r=this.calculateDistToStraightLine(t,e,l,c);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=s)}return n}calculateDistToStraightLine(t,e,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return t>=r-2&&t<=o+2&&e>=s-2&&e<=a+2?this.distToStraightLineSegment(t,e,n,i):null}distToStraightLineSegment(t,e,n,i){const r=(t,e,n,i)=>Math.pow(t-n,2)+Math.pow(e-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(t,e,n.x,n.y);let s=((t-n.x)*(i.x-n.x)+(e-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(t,e,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(t,e,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(e>=s-2&&e<=a+2&&n>=l-2&&n<=c+2){const t=a-s,h=c-l;return this.calculateDistToCurveInRect(e,n,i,o,r,t,h)}return null}calculateDistToCurveInRect(t,e,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(t-a),f=Math.abs(e-p),g=m+f;(!d||d>g)&&(d=g),u[o]=Math.max(m,f),c[o]=a,h[o]=p}for(let t=0;t<c.length;t++)u[t]<d&&p.setBit(t,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-t,h[n]-e);(!m||m>i)&&(m=i)}return m}getLineLength(t,e,n,i){return Math.sqrt(Math.pow(n-t,2)+Math.pow(i-e,2))}getPointOnDistance(t,e,n,i,r,o){const s=n-r*((n-t)/o),l=i-r*((i-e)/o);return new a.Point(s,l)}findControlPoint(t,e,n,i,r,o){const s=e+(i-e)/2,l=n+(r-n)/2;let c=s-e,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(t/2);return t%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(t,e,n,i,r){const o=Math.atan2(i-e,r-n)+Math.PI;t.moveTo(e-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),t.lineTo(e,n),t.lineTo(e-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}var U,W,q=n(8060),z=n(3629);async function Y(t,e,i,r,s,a,l){let c=await async function(t,e,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(t.length!==e.length||t.length!==a.distanceFnArgs.length||t.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:t,distanceMetrics:e,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(q.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:t,embedding:e,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),t?h(t):c(e),setTimeout((()=>u.terminate()),100)):l&&l(n,i,e)}}))}(t,i,e,r,s,a,l);return c=c.map((t=>(0,z.S8)(t))),c}(W=U||(U={})).EUCLIDEAN="EUCLIDEAN",W.MANHATTAN="MANHATTAN";const K={[U.EUCLIDEAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n        }\n        return sqrt(sum);\n    `},[U.MANHATTAN]:function(t){return`\n        var sum = 0.0;\n        for (var i = 0u; i < ${t}; i = i + 1u) {\n            sum = sum + abs(distances[i]) * computeInfo.weights[i];\n        }\n        return sum;\n    `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.VECTOR_COSINE="Vector Cosine",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + f32(a[i] != b[i]);\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.EUCLIDEAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n  }\n  return sqrt(dist);\n  `},[Z.MANHATTAN]:function(t,e){return`\n  var dist: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    dist = dist + abs(f32(a[i] - b[i]));\n  }\n  return dist;\n  `},[Z.VECTOR_COSINE]:function(t,e){return`\n  var dist: f32 = 0.0;\n  var productSum: f32 = 0.0;\n  var aSquareSum: f32 = 0.0;\n  var bSquareSum: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n    productSum = productSum + f32(a[i] * b[i]);\n    aSquareSum = aSquareSum + f32(a[i] * a[i]);\n    bSquareSum = bSquareSum + f32(b[i] * b[i]);\n  }\n  var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n  return (1.0 - sim) / 2.0;\n  `},[Z.TANIMOTO]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n\n  if (onBitsa == 0u && onBitsb == 0u) {\n      return 0.0;\n  }\n\n  let totalOnBits = onBitsa + onBitsb;\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n\n  return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n  `},[Z.LEVENSTEIN]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n\n  let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n  // we will store two arrays as matrix and swap the working indices per pass.\n  // this way we can reduce memory usage per computation to just O(aLength)\n  // the grid will have aLength + 1 columns and bLength + 1 rows\n  // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n  var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n  \n  var prevIndex: u32 = 0;\n  var curIndex: u32 = 1; // we will swap these indices per pass\n\n  // initialize the first row\n  for (var i = 0u; i <= aLength; i = i + 1u) {\n      dynamicPassMat[prevIndex][i] = f32(i);\n  }\n\n  // iterate over the rows\n  for (var i = 1u; i <= bLength; i = i + 1u) {\n      dynamicPassMat[curIndex][0] = f32(i);\n      var minEntry: f32 = f32(maxLength);\n      let prevRow = &dynamicPassMat[prevIndex];\n      let curRow = &dynamicPassMat[curIndex];\n      let bMon = u32(b[i - 1]);\n      for (var j = 1u; j <= aLength; j = j + 1u) {\n          var cost: f32 = f32(a[j - 1] != bMon);\n          var res: f32 = min(\n              min(\n                (*prevRow)[j] + 1.0, // deletion\n                (*curRow)[j - 1] + 1.0, // insertion\n              ),\n              (*prevRow)[j - 1] + cost // substitution\n              );\n              (*curRow)[j] = res;\n          if (res < minEntry) {\n              minEntry = res;\n          }\n      }\n      // swap the indices\n      let temp: u32 = prevIndex;\n      prevIndex = curIndex;\n      curIndex = temp;\n      if (minEntry > maxIntDistance) {\n          return 1.0;\n      }\n  }\n\n  return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n  `},[Z.NEEDLEMAN_WUNSCH]:function(t,e){return`\n      let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n      let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n      let maxLength: u32 = max(aLength, bLength);\n      let minLength: u32 = min(aLength, bLength);\n  \n      let maxIntDistance = ceil(maxDistance * f32(maxLength));\n      // we will store two arrays as matrix and swap the working indices per pass.\n      // this way we can reduce memory usage per computation to just O(aLength)\n      // the grid will have aLength + 1 columns and bLength + 1 rows\n      // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n      var dynamicPassMat: array<array<f32, ${t+1}u>, 2>; // initialize to 0\n      \n      // we need to keep track of which operation led to the current cell\n      // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n      var verticalGaps: array<u32, ${t+1}u>;\n      var horizontalGaps: array<u32, ${t+1}u>;\n\n      let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${e};\n      let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${e};\n      var prevIndex: u32 = 0;\n      var curIndex: u32 = 1; // we will swap these indices per pass\n      // initialize the first row\n      for (var i = 0u; i <= aLength; i = i + 1u) {\n          dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n          dynamicPassMat[curIndex][i] = 0.0;\n      }\n      dynamicPassMat[0][0] = 0.0;\n\n      let simMatrix = &suppInfo.similarityMatrix${e}; // using pointers make things faster\n      // iterate over the rows\n      for (var i = 1u; i <= bLength; i = i + 1u) {\n          let prevRow = &dynamicPassMat[prevIndex];\n          let curRow = &dynamicPassMat[curIndex];\n          (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n          var minEntry: f32 = f32(maxLength);\n          let monB = u32(b[i - 1]);\n          for (var j = 1u; j <= aLength; j = j + 1u) {\n              let monA = u32(a[j - 1]);\n              \n              let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n              var top = (*prevRow)[j]; // deletion\n              if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n                  top = top + gapExtensionPenalty;\n              } else {\n                  top = top + gapOpenPenalty;\n              }\n              var left = (*curRow)[j - 1]; // insertion\n              if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n                  left = left + gapExtensionPenalty;\n              } else {\n                  left = left + gapOpenPenalty;\n              }\n              var res: f32 = min(\n                  min(\n                      top, // deletion\n                      left, // insertion\n                  ),\n                  cost // substitution\n                  );\n                  (*curRow)[j] = res;\n              if (res < minEntry) {\n                  minEntry = res;\n              }\n              // update the horizontal and vertical gaps\n              if (res == cost) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 0;\n              } else if (res == left) {\n                  verticalGaps[j] = 0;\n                  horizontalGaps[j] = 1;\n              } else {\n                  verticalGaps[j] = 1;\n                  horizontalGaps[j] = 0;\n              }\n          }\n          // swap the indices\n          let temp: u32 = prevIndex;\n          prevIndex = curIndex;\n          curIndex = temp;\n          if (minEntry > maxIntDistance) {\n              return 1.0;\n          }\n      }\n      return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n  `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  let maxLength: u32 = max(aLength, bLength);\n  let minLength: u32 = min(aLength, bLength);\n  let sizeDiff: u32 = maxLength - minLength;\n  \n  let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n  let simMatrix = &(suppInfo.similarityMatrix${e}); // using pointers make things faster\n  var diff: f32 = 0.0;\n  for (var i = 0u; i < ${t}; i = i + 1u) {\n      diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n      if (diff > maxIntDistance) {\n            return 1.0;\n        }\n  }\n  diff += f32(sizeDiff);\n  return diff / ${t};\n  `},[Z.SOKAL]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa + onBitsb;\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n  `},[Z.COSINE]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n  if (total == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / sqrt(f32(total));\n  `},[Z.ASYMMETRIC]:function(t,e){return`\n  var onBitsa: u32 = 0u;\n  var onBitsb: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      onBitsa = onBitsa + countOneBits(a[i]);\n      onBitsb = onBitsb + countOneBits(b[i]);\n  }\n  let min = min(onBitsa, onBitsb);\n  if (min == 0u) {\n    return 1.0;\n  }\n  var commonBits: u32 = 0u;\n  for (var i = 0u; i < ${t}u; i = i + 1u) {\n      commonBits = commonBits + countOneBits(a[i] & b[i]);\n  }\n  return 1.0 - f32(commonBits) / f32(min);\n  `},[Z.Difference]:function(t,e){return`\n    let range = suppInfo.range${e};\n    return f32(abs(f32(a[0]) - f32(b[0])) / range);\n  `},[Z.OneHot]:function(t,e){return`\n  let aLength: u32 = computeInfo.entrySizes[${e}][aIndex];\n  let bLength: u32 = computeInfo.entrySizes[${e}][bIndex];\n  if (aLength != bLength) {\n    return 1.0;\n  }\n  for (var i = 0u; i < aLength; i = i + 1u) {\n    if(a[i] != b[i]) {\n      return 1.0;\n    }\n  }\n  return 0.0;\n  `}},Q={[Z.HAMMING]:t=>Math.ceil(t/30),[Z.EUCLIDEAN]:t=>Math.ceil(t/30),[Z.MANHATTAN]:t=>Math.ceil(t/30),[Z.TANIMOTO]:t=>Math.ceil(t/30),[Z.SOKAL]:t=>Math.ceil(t/30),[Z.COSINE]:t=>Math.ceil(t/30),[Z.ASYMMETRIC]:t=>Math.ceil(t/30),[Z.LEVENSTEIN]:t=>Math.ceil(t*t/60),[Z.NEEDLEMAN_WUNSCH]:t=>Math.ceil(t*t/60),[Z.MONOMER_CHEMICAL_DISTANCE]:t=>Math.ceil(t/25),[Z.Difference]:t=>1,[Z.OneHot]:t=>Math.ceil(t/40),[Z.VECTOR_COSINE]:t=>Math.ceil(t/30)},tt={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.VECTOR_COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference,Z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference,Z.VECTOR_COSINE]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var et=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function nt(t,e,n,i){return t.map(((t,i)=>`\n        fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n          let a = computeInfo.data${i}[aIndex];\n          let b = computeInfo.data${i}[bIndex];\n          let maxDistance: f32 = ${n};\n          ${J[t](e[i],i)}\n        }\n      `)).join("\n")+"\n"+`\n      fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n        var distances: array<f32, ${t.length}>;\n        ${t.map(((t,e)=>`distances[${e}] = distanceScript${e}(aIndex, bIndex);`)).join("\n")}\n        ${K[i](t.length)}\n      }\n    \n    `}var it=n(1991),rt=n.n(it);let ot=0;const st="cliffsDf",at=new h.Subject,lt="Δ activity",ct="SALI",ht="Similarity",ut="line index",dt=["From","To"],pt="filterCliffs";async function mt(t,e,i,r,l,c,h,u,d,p,m,f,g,y,b,v,w){ot++;const C=c/100;let A,S=!1;const x=f.inputs,I=await f.apply({[x[0].name]:e,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let T=[];if(u===N){const e=await function(t,e,i,r,o,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:t,threshold:e,weights:i,aggregationMethod:r,distanceFns:o,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((t,e)=>{u=t,h.onmessage=e=>{setTimeout((()=>h.terminate()),100),t(e.data.res)},h.onerror=t=>{setTimeout((()=>h.terminate()),100),e(t)}})),terminate:()=>{try{u(null),h.terminate()}catch(t){console.error(t)}}}}([I.entries],c,[1],"MANHATTAN",[h],[I.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;t.columns.addNewInt(t.columns.getUnusedName("MCL Cluster")).init((t=>e.clusters[t])),T=[e.embedX,e.embedY]}else T=await Y([I.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[I.options??{}]});if(T.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let e=0;e<T.length;++e)t.columns.addNewFloat(i[e]).init((t=>T[e][t]));let L=null;if(d.useWebGPU)try{L=await function(t,e=.8,n,i,r,o){return et(this,void 0,void 0,(function*(){const s=yield function(){return E(this,void 0,void 0,(function*(){if(!navigator.gpu)return console.error("WebGPU is not supported in this browser"),null;if(!M&&(M=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==M))return null;let t=!1;if(_&&(_.lost.then((()=>{t=!0})),yield new Promise((t=>setTimeout(t,10)))),!_||t){const t=1e9,e=M.limits,n=e.maxBufferSize,i=e.maxStorageBufferBindingSize;try{return _=yield M.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,t),maxStorageBufferBindingSize:Math.min(i,t)}}),_}catch(t){return console.error("Failed to create device with required limits",t),_=yield M.requestDevice(),_}}return _}))}();if(!s)return null;const a=Object.values(Z);if(n.some((t=>!a.includes(t))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(U).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-e;if(o.length!==t.length||o.length!==n.length||o.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(t.some((e=>e.length!==t[0].length)))throw new Error("All entry lists must be the same length");const c=t.length,h=t[0].length,u=t.map(((t,e)=>function(t,e=Z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,o;let s=null;const a=t.some((t=>"string"==typeof t))?(s="STRING",t.map((t=>new Uint32Array(t.split("").map((t=>t.charCodeAt(0))))))):t.some((t=>"number"==typeof t))?(s="NUMBER",t.map((t=>new Float32Array([t])))):"object"==typeof t[0]&&t.some((t=>"_data"in t&&"_length"in t))?(s="BITARRAY",t.map((t=>t._data))):t.some((t=>t instanceof Float32Array))?(s="FLOAT32ARRAY",t):t.some((t=>t instanceof Uint32Array))?(s="UINT32ARRAY",t):t.some((t=>t instanceof Int32Array))?(s="INT32ARRAY",t):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((t=>t.length)));if(!tt[s]||!tt[s].has(e))throw new Error(`Distance metric '${e}' not supported for entry type '${s}'`);const h=c.reduce(((t,e)=>Math.max(t,e)),0),u=Q[e](h),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*h);a.forEach(((t,e)=>{p.set(t,e*h)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(e===Z.NEEDLEMAN_WUNSCH||e===Z.MONOMER_CHEMICAL_DISTANCE){let t=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((t,e)=>Math.max(t,e.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let e=0;e<p.length;e++)p[e]>t&&(t=p[e]);i.scoringMatrix=new Array(t+1).fill(null).map((()=>new Array(t+1).fill(0))),i.alphabetIndexes={};for(let t=0;t<i.scoringMatrix.length;t++)i.scoringMatrix[t][t]=1,i.alphabetIndexes[String.fromCharCode(t)]=t}const e=(t+1)*(t+1),s=new Array(t+1).fill(null).map((()=>new Float32Array(t+1)));for(let e=0;e<t+1;e++)s[e][e]=1;const a=i.alphabetIndexes;for(const t of Object.keys(a))for(const e of Object.keys(a))t!==e&&(s[t.charCodeAt(0)][e.charCodeAt(0)]=i.scoringMatrix[a[t]][a[e]]);f=2+e,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=i.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(o=i.gapExtensionPenalty)&&void 0!==o?o:.6;let l=2;for(let t=0;t<s.length;t++)y.set(s[t],l),l+=s[t].length;m=`\n            gapOpenPenalty${n}: f32,\n            gapExtensionPenalty${n}: f32,\n            similarityMatrix${n}: array<array<f32, ${t+1}>, ${t+1}>`}else if(e===Z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const t=p.reduce(((t,e)=>Math.min(t,e)),p[0]),e=p.reduce(((t,e)=>Math.max(t,e)),p[0]);i.range=e-t}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n            range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(t,n[e],e,o[e])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=u.map((t=>t.suppInfoStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((t=>t.dataStructWgsl)).filter((t=>!!t&&""!=t)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((t,e)=>{f.set(t.arraySizes,e*h)}));const g=1e4,y=100,b=u.reduce(((t,e)=>t+e.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n    // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n    // in total, each thread will perform at most ${S} comparisons.\n    // first is the result struct, containing is, js, and distances. each array with length of 100,\n    // and also integer for how many pairs were found to be below threshold.\n    struct SparseResult {\n      i: array<array<u32, 100>, 10000>,\n      j: array<array<u32, 100>, 10000>,\n      distances: array<array<f32, 100>, 10000>,\n      found: array<u32, 10000>,\n      done: array<u32, 10000>\n    }\n    // struct for the data\n    struct ComputeInfo {\n      // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n      startAtCols: array<u32, 10000>,\n      startAtRows: array<u32, 10000>,\n      endAtCols: array<u32, 10000>,\n      endAtRows: array<u32, 10000>,\n\n      // the ACTUALLY sizes of each entry\n      entrySizes: array<array<u32, ${h}>, ${c}>,\n      // the weights for each entry\n      weights: array<f32, ${c}>,\n      // the data for each entry\n      ${m} // an example of the dataWgsl would be:\n      //data0: array<array<u32,20>,100>,\n      //data1: array<array<u32,20>,100>\n    }\n\n    // struct for the supplementary information\n    struct SuppInfo {\n      // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n      ${d}\n    };\n\n    @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n    @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n    @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n    @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n      @builtin(global_invocation_id) id: vec3<u32>\n    ) {\n      ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n      let threadCol = id.x;\n      let threadRow = id.y;\n      let linearIndex = threadRow * ${C} + threadCol;\n      if (linearIndex >= 10000) {\n        return; // if we are out of bounds, return\n      }      \n      var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n      var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n      let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n      let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n      let is = &results.i[linearIndex];\n      let js = &results.j[linearIndex];\n      let distances = &results.distances[linearIndex];\n      results.found[linearIndex] = 0; // initialize the found counter\n      var found: u32 = 0;\n      if (results.done[linearIndex] > 0) {\n        return; // if we are done, return\n      }\n      for (var i = 0; i < ${v}; i++) {\n        if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n          results.done[linearIndex] = 1;\n          break;\n        }\n        if (found >= 100) {\n          break;\n        }\n        let dist = combinedDistance(startAtCol, startAtRow);\n        if (dist <= ${l}) {\n          (*is)[found] = startAtCol;\n          (*js)[found] = startAtRow;\n          (*distances)[found] = dist;\n          found = found + 1;\n        }\n        startAtCol = startAtCol + 1;\n        if (startAtCol >= ${h}u) {\n          startAtRow += 1;\n          startAtCol = startAtRow + 1;\n        }\n      }\n      results.found[linearIndex] = found;\n      // update the startAtCols and startAtRows\n      computeInfo.startAtCols[linearIndex] = startAtCol;\n      computeInfo.startAtRows[linearIndex] = startAtRow;\n\n    }\n\n    // this will generate the distance script for each distance metric and then combine them into one\n    ${nt(n,u.map((t=>t.maxEntryLen)),l,i)}\n\n\n    `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),P=new Uint32Array(g),$=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let t=0;t<g;t++){const e=9999===t?A-1:(t+1)*$,n=h-2-Math.floor(Math.sqrt(-8*e+4*h*(h-1)-7)/2-.5),i=e-h*n+Math.floor((n+1)*(n+2)/2);T[t]=O,L[t]=R,N[t]=i,P[t]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce(((t,e)=>t+e.sourceArraySize),0),G=u.reduce(((t,e)=>t+e.suppInfoSize),0),F=1e6,H=k*Uint32Array.BYTES_PER_ELEMENT;let B=H;const D=15&H;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,g).set(T),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(L),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(N),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(P),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f.length).set(f),W+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,W,c).set(r),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const t of u){const e=t.EncodedArrayConstructor,n=t.sourceArraySize;new e(j,W,n).set(t.flatSourceArray),W+=n*e.BYTES_PER_ELEMENT}V.unmap();const q=G*Uint32Array.BYTES_PER_ELEMENT;let z=q;const Y=15&q;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const t of u)t.suppInfoBuffer&&t.suppInfoBuffer.byteLength>0&&t.suppInfoSize>0&&(new("UINT32ARRAY"===t.suppInfoType?Uint32Array:Float32Array)(X,J,t.suppInfoBuffer.length).set(t.suppInfoBuffer),J+=t.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const et=302e4*Uint32Array.BYTES_PER_ELEMENT;let it=et;const rt=15&et;0!==rt&&(it+=16-rt);const ot=s.createBuffer({label:"results buffer",size:it,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),st=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:ot}}]}),at=s.createBuffer({label:"results out buffer",size:ot.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),lt=[],ct=[],ht=[];let ut=!1;for(;!ut;){const t=s.createCommandEncoder({label:"distance encoder"}),e=t.beginComputePass({label:"distance compute pass"});e.setPipeline(I),e.setBindGroup(0,st),e.dispatchWorkgroups(w,w),e.end(),t.copyBufferToBuffer(ot,0,at,0,at.size);const n=t.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield at.mapAsync(GPUMapMode.READ);const i=at.getMappedRange();let r=0;const o=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,ut=new Uint32Array(i,r,g).every((t=>1===t));const h=c.reduce(((t,e)=>t+e),0),u=new Uint32Array(h),d=new Uint32Array(h),p=new Float32Array(h);let m=0;for(let t=0;t<c.length;t++){const e=c[t];0!==e&&(u.set(o.subarray(t*y,t*y+e),m),d.set(a.subarray(t*y,t*y+e),m),p.set(l.subarray(t*y,t*y+e),m),m+=e)}lt.push(u),ct.push(d),ht.push(p),at.unmap()}const dt=lt.reduce(((t,e)=>t+e.length),0),pt=new Uint32Array(dt),mt=new Uint32Array(dt),ft=new Float32Array(dt);let gt=0;for(let t=0;t<lt.length;t++)pt.set(lt[t],gt),mt.set(ct[t],gt),ft.set(ht[t],gt),gt+=lt[t].length;return V.destroy(),K.destroy(),ot.destroy(),at.destroy(),{i:pt,j:mt,distance:ft}}))}([I.entries],C,[h],U.MANHATTAN,[1],[I.options??{}])}catch(t){console.error(t)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new H).calc(I.entries,h,C,I.options));const P=await async function(t,e){const n=t.distance.map(((n,i)=>{const r=Math.abs(e.get(t.i[i])-e.get(t.j[i]));return 0!=n?r/n:1/0})),i=t.distance.map((t=>1-t)),r=t.i,o=t.j,s=a.BitSet.create(e.length);return t.distance.forEach(((e,n)=>{s.set(t.i[n],!0),s.set(t.j[n],!0)})),{simVals:i,saliVals:n,n1:r,n2:o,cliffsBitSet:s}}(L,l),$=function(t,e,n,i,r,o,s){const l=new Array(t).fill(0);for(let t=0;t!=i.length;++t)n[t]!=1/0&&(s.get(i[t])>s.get(r[t])?l[i[t]]+=n[t]:l[r[t]]+=n[t]);return a.Column.fromList("double",e,l)}(e.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,P.saliVals,P.n1,P.n2,0,l);t.columns.add($);const O=P.cliffsBitSet,k=function(t){const e=t.filter((t=>t!==1/0)),n=e.reduce(((t,e)=>Math.min(t,e)),Number.MAX_VALUE);return{max:e.reduce(((t,e)=>Math.max(t,e)),n),min:n}}(P.saliVals),G=.8/(k.max-k.min),F=o.shell.getTableView(t.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:$.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(t,e,n,i,r,o,s,l){const c={from:new Uint32Array(e.n1.length),to:new Uint32Array(e.n1.length),opacities:new Float32Array(e.n1.length),colors:new Array(e.n1.length),widths:new Float32Array(e.n1.length)};for(let n=0;n<e.n1.length;n++)c.from[n]=e.n1[n],c.to[n]=e.n2[n],c.opacities[n]=e.saliVals[n]===1/0?1:.2+(e.saliVals[n]-s.min)*l,c.colors[n]=t.selection.get(c.from[n])&&t.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return dt.forEach(((t,e)=>{h.columns.addNewString(t).init((t=>n.get(0===e?c.from[t]:c.to[t]))),function(t,e){Object.keys(e).forEach((n=>{t.tags[n]=e[n]}))}(h.col(t),o),h.col(t).semType=r})),h.columns.addNewFloat(lt).init((t=>Math.abs(i.get(c.from[t])-i.get(c.to[t])))),h.columns.addNewInt(ut).init((t=>t)),h.columns.addNewFloat(ct).init((t=>e.saliVals[t])),h.columns.addNewFloat(ht).init((t=>e.simVals[t])),h.name=`${st}${ot}`,{lines:c,linesDf:h}}(t,P,e,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ct).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const W=new j(D,i[0],i[1],V.lines,B.none),q=b?b(V.linesDf,dt).sort([ct],[!1]):V.linesDf.plot.grid().sort([ct],[!1]);q.col(ut)&&(q.col(ut).visible=!1),t.temp[".cliffsDfGrid"]=q;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{const t=rt()(F.viewers).some((t=>t.dataFrame.name===`${st}${ot}`));w&&!t&&F.addViewer(q),F.dockManager.dock(q,"down",null,"Activity cliffs",v??.2)}));z.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:e=>{e?(D.dataFrame.setTag(pt,i[0]),t.filter.and(O),at.next(i[0])):(D.dataFrame.setTag(pt,""),t.filter.setAll(!0),at.next(""))}});D.root.prepend(s.divH([z,K.root],"cliffs_div")),at.subscribe((t=>{K.enabled=""===t||t===i[0]}));let X=!1;D.onEvent("d4-before-draw-scene").subscribe((e=>{X?X=!1:K.value&&(setTimeout((()=>{t.filter.and(O)}),100),X=!0)}));const J=o.events.onViewerClosed.subscribe((t=>{t.args.viewer===D&&(F.dockManager.close(q.root),J.unsubscribe(),F.subs=F.subs.filter((t=>t!==J)))}));return F.subs.push(J),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let t=0;t<V.linesDf.rowCount;t++)V.lines.widths[t]=t===V.linesDf.currentRowIdx?3:1;W.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===dt[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;W.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(t,e,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=t/s,c=e/a,h=Math.min(l,c),u=t/h*5,d=e/h*5,p=(n<r?n:r)+s/2-u/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],V.lines.from[n]),D.dataFrame.get(i[1],V.lines.from[n]),D.dataFrame.get(i[0],V.lines.to[n]),D.dataFrame.get(i[1],V.lines.to[n]));D.zoom(a,h,c,u),K.value?t.filter.and(O):!0===K.enabled&&t.filter.setAll(!0),setTimeout((()=>{!function(t,e,n,i,r,a,l,c,h){const u=e.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:r,df:t,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{o.shell.o=e.root}),500)}(t,A,V.lines.from[r],V.lines.to[r],r,e,l,V.linesDf.get(ct,r),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(e.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((e=>{setTimeout((()=>(()=>{const e=a.BitSet.create(t.rowCount);for(let t=0;t<V.linesDf.rowCount;t++){const n=V.linesDf.selection.get(t);n&&(e.set(V.lines.from[t],!0),e.set(V.lines.to[t],!0)),V.lines.colors[t]=n?"255,255,0":"0,128,0"}t.selection.copyFrom(e),W.linesToRender=V.lines})()),100)})),t.onSelectionChanged.subscribe((e=>{!1===t.selection.anyTrue&&"number"==typeof e&&(S?S=!1:(t=>{t.selection.setAll(!1);for(let t=0;t<V.lines.colors.length;t++)V.lines.colors[t]="0,128,0";W.linesToRender=V.lines})(q.dataFrame))})),W.lineClicked.subscribe((e=>{if(S=!0,W.currentLineId=e.id,-1!==e.id){const n=V.linesDf.selection.clone();setTimeout((()=>{e.event.ctrlKey?(n.set(e.id,!n.get(e.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==e.id&&(V.linesDf.currentRowIdx=e.id,t.currentRowIdx=V.lines.from[e.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(q.sortByColumns,q.sortTypes);q.scrollToCell(dt[0],i.indexOf(e.id))}),500)}})),W.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===t.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:t,seqCol:e,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const t=s.accordion(),e=s.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(s.span([e,s.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),o.shell.o=t.root,t}(),D}var ft,gt=n(2003),yt=n(3516),bt=n(6718),vt=n(3077),wt=n(439);!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(ft||(ft={}));var Ct=n(9192);class At{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n      0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n      perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class St extends ${constructor(t={}){super({...t,enableMCL:!0});const e=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new At}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const t=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(t){super.applyInput(t),this.activitiesInput.value=this.tableInput.value.col(t.activityCol),this.similarityInput.value=t.simThreshold}}var xt,Et,Mt,_t=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};function It(t){const e=["Embed_X","Embed_Y"],n=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${n}`))}function Tt(t,e){return`${e} (${t.length>4?`${t.length} columns`:t.map((t=>t.name)).join(", ")})`}n(5540),function(t){t.ADD="ADD",t.SUB="SUB",t.MULT="MULT"}(xt||(xt={})),function(t){t.SQUARE="SQUARE",t.INVERSE="INVERSE",t.TRANSPOSE="TRANSPOSE",t.NORM="NORM",t.COLUMN_NORM="COLUMN_NORM"}(Et||(Et={})),function(t){t.SCALARMULT="SCALARMULT",t.SCALARADD="SCALARADD",t.SCALARPOW="SCALARPOW"}(Mt||(Mt={})),Object.prototype.toString;var Lt=n(6873),Nt=n(4356),Pt=n(6717),$t=n(4870),Rt=n(3856),Ot=n(6882),kt=n(7278),Gt=n(5553),Ft=n(6642),Ht=n(3599),Bt=n(673),Dt=n(8312);class Vt extends Ft.sD{monomerLib=null;seqHelper=null;constructor(t,e){super(t,e,Di.logger),(0,bt.pj)().then((t=>{this.monomerLib=t.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,Dt.Q)().then((t=>{this.seqHelper=t,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var jt=n(4139);const Ut=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class Wt extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(t){this.seqHandler.column.set(this.rowIdx,t)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===wt.YI.DNA}isRna(){return this.seqHandler.alphabet===wt.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===wt.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(t,e){if(null==e.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=e.column.dataFrame.cell(t,e.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=t,this.seqHandler=e}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const t=(0,kt.qp)(this.helm),e=[],n=/\(|\)/;for(let i=0;i<t.length;i++){const r=t.getOriginal(i),o=r.split(n).filter((t=>!!t));3===o.length?(e.push(o[0]),e.push(o[1]),e.push(o[2])):e.push(r)}return new kt.Mu(e,this.seqHandler.defaultGapOriginal)}}const qt=gt.zS;function zt(t){const e=!rt().enumerate(t).some((([e,n])=>e.length>1&&0!=n&&n!=t.length-1)),n=[],i=e?"":" ";for(const[e,r]of rt().enumerate(t)){let o=e;r<t.length&&(o+=`${e?"":"-"}${i}`),n.push(o)}return[n,e]}class Yt extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=Di.seqHelper}getRendererBack(t){const[e,n,i]=(0,Ft.BG)(t);if(n.meta.units!==gt.Hi.CUSTOM)return i.rendererBack;let r=null;return this.seqHelper&&(r=this.seqHelper.getSeqHandler(n).getRendererBack(e,n)),r}onClick(t,e){if(t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate(),t.cell.column.meta.units===gt.Hi.CUSTOM){const n=this.getRendererBack(t);n?.onClick(t,e)}}onMouseEnter(t,e){const n=this.getRendererBack(t);n?.onMouseEnter(t,e),this.hasMouseOver=!0}onMouseMove(t,e){const n=this.getRendererBack(t);n?.onMouseMove(t,e)}onMouseLeave(t,e){if((0,Gt.WN)(t,null),t?.grid){const e=t.grid.onEvent("d4-grid-show-tooltip").subscribe((t=>{e.unsubscribe(),this.hasMouseOver&&t.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(t,e){const n=this.getRendererBack(t);n?.onDoubleClick(t,e)}onKeyDown(t,e){const n=this.getRendererBack(t);n?.onKeyDown(t,e)}onKeyPress(t,e){const n=this.getRendererBack(t);n?.onKeyPress(t,e)}renderInt(t,e,n,i,r,o,s){const[a,l,c]=(0,Ft.BG)(o);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(Di.properties?Di.properties.maxMonomerLength:4)??50;if(Rt.gp.maxMonomerLength in l.tags){const t=parseInt(l.getTag(Rt.gp.maxMonomerLength));d=!isNaN(t)&&t?t:50}if(".mm.cellRenderer.maxMonomerLength"in h){const t=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(t)&&t?t:50}let p=c.rendererBack;p||(p=c.rendererBack=new Ot.Jy(a,l,Di.logger,d,(()=>{const{font:t,fontWidth:e}=Ot.Jy.getFontSettings(l);return{font:t,fontCharWidth:e,separatorWidth:u.isMsa()?8:0,monomerToShort:qt}})),l.temp[".mm.cellRenderer.settingsChanged"],Bt.s.true,p.init().then((()=>{}))),p.render(t,e,n,i,r,o,s)}render(t,e,n,i,r,o,s){if(o.cell.column?.meta?.units!==gt.Hi.CUSTOM)this.renderInt(t,e,n,i,r,o,s);else{const a=this.getRendererBack(o);a?.render(t,e,n,i,r,o,s)}}}class Kt extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell.value??"",h=this.tableCol.tags[gt.gp.separator],u=this.tableCol.meta.units;i=(0,Ot.U0)(l,t,e,i,a);const[d,p]=c.split("#"),m=this.tableCol.temp[Ut.notationProvider]?.separatorSplitter??(0,kt.Iv)(u,h),f=m(d),g=m(p),y=rt().count(0).take(f.length).map((t=>f.getCanonical(t))).toArray(),b=rt().count(0).take(g.length).map((t=>g.getCanonical(t))).toArray(),v=this.tableCol.getTag(gt.gp.alphabet);Xt(t,e,n,i,r,y,b,v===gt.YI.RNA||v===gt.YI.DNA?Ht.o.NUCLEOTIDE:Ht.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Ft.BG)(t);let r=i.rendererBack;return r||(r=i.rendererBack=new Kt(e,n)),r}}class Zt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return jt.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,n,i,r,o,s){Kt.getOrCreate(o).render(t,e,n,i,r,o,s)}}function Xt(t,e,n,i,r,o,s,a,l,c,h){if(o.length!==s.length){const t=function(t,e){let n=0,i=0;const r=t.length>e.length?t:e,o=t.length>e.length?e:t;for(let t=0;t<o.length;t++)r[t]===o[t]&&n++;const s=r.length-o.length;for(let t=r.length-1;t>s;t--)r[t]===o[t-s]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill(wt.b9[gt.Hi.FASTA]);function l(t){return n>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(rt()(e).toArray()):t=l(rt()(t).toArray()),{subParts1:t,subParts2:e}}(o,s);o=t.subParts1,s=t.subParts2}const u=t.measureText(zt(o).join("")),d=t.measureText(zt(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*o.length,t.canvas.width=p+4*o.length);let m=Math.max(e,e+(i-(p+4*o.length))/2)+5;const f=Math.max(n,n+(r-28)/2);t.save();try{t.beginPath(),t.rect(e,n,c?p+4*o.length:i,r),t.clip(),t.font="12px monospace",t.textBaseline="top";const u=7;for(let e=0;e<o.length;e++){const n=o[e],c=s[e];let d=Ot.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let o=Ot.S$;l&&(o=l.getMonomerTextColor(a,c));const s=(0,Rt.oZ)(t,n,m,f-u,i,r,{color:d,pivot:0,left:!0}),p=(0,Rt.oZ)(t,c,m,f+u,i,r,{color:o,pivot:0,left:!0});m=Math.max(p,s),h&&(h[e]=Jt(n,c,d,o,f,u,r))}else m=(0,Rt.oZ)(t,n,m,f,i,r,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{t.restore()}}function Jt(t,e,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(zt([t]).join("")).width,h=l.measureText(zt([e]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Rt.oZ)(l,t,0,r-o,u,s,{color:n,pivot:0,left:!0}),(0,Rt.oZ)(l,e,0,r+o,u,s,{color:i,pivot:0,left:!0}),a}var Qt,te=n(8070),ee=n(4326);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(Qt||(Qt={}));const ne=new class{constructor(){this.regionTypes=[Qt.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ee.fH.Entropy,this.filterSource=ee.Fo.filterSource}};var ie=n(7602),re=n(250);const oe=Qt;var se,ae;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(se||(se={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(ae||(ae={}));const le=ne;class ce extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ae.skipEmptyPositions,le.skipEmptyPositions,{category:se.DATA}),this.regionTypes=this.stringList(ae.regionTypes,le.regionTypes,{category:se.DATA,choices:Object.values(oe).filter((t=>t!=oe.Unknown))}),this.chains=this.stringList(ae.chains,le.chains,{category:se.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ae.fitWidth,le.fitWidth,{category:se.LAYOUT}),this.positionWidth=this.float(ae.positionWidth,le.positionWidth,{category:se.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ae.positionHeight,le.positionHeight,{category:se.LAYOUT,choices:Object.keys(ee.fH)}),this.filterSource=this.string(ae.filterSource,le.filterSource,{category:se.BEHAVIOR,choices:Object.values(ee.lT)}),this.viewSyncer=new ie.g(Di.logger)}static viewerCounter=-1;viewerId=++ce.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=`${this.viewerToLog()}.detach()`,e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),e())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case ae.regionTypes:case ae.chains:this.setData(this.regions)}switch(t.name){case ae.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ae.fitWidth:case ae.positionWidth:this.calcSize();break;case ae.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ae.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){const e=`${this.viewerToLog()}.setData()`;Di.logger.debug(`${e}, in, regions.length = ${t.length}`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(t){Di.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Di.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),n=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<n.length;t++)for(const r of this.chains){const o=e.find((e=>e.order==n[t]&&e.chain==r));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,r,e]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let t=0;t<n.length;++t)this.logos[t]={};for(const[t,e,n]of r)this.logos[t][e]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(t=>[...n.length>0?[s.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((e=>{const n=this.logos[e][t];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((t=>e.find((e=>e.order==n[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(ee.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Di.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Di.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let n=0;n<this.logos.length;n++){for(const e of this.chains)this.logos[n][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[n][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,n=13,i=9,r=(this.root.clientWidth-t-(this.logos.length-1)*i-n)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const n=this.logos[t][e];n.setOptions({[re.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[re.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,e=this.filterSourceInput.value;this.viewSyncer.sync(`${t}`,(async()=>{if(this.filterSource!==e){this.props.getProperty(ae.filterSource).set(this,e);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const n=this.chains[e];this.logos[t][n].setOptions({[re.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.viewerToLog()}.invalidate(${t?` <- ${t} `:""})`;this.viewSyncer.sync(`${e}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,te.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}var he=n(6625),ue=n(6863);async function de(t,e,n="Morgan"){const i=t.length,r=Di.seqHelper.getSeqHandler(t),o=Array(i);let s=1;const a=new Map,l=t.categories,c=t.getRawData();for(let e=0;e<i;e++){if(null===l[c[e]]||t.isNone(e)){o[e]=null;continue}o[e]="";const n=r.getSplitted(e);for(let t=0;t<n.length;t++){const i=n.getCanonical(t);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[e]+=a.get(i)}}let h={};if(e===ue.Z.MONOMER_CHEMICAL_DISTANCE||e===ue.Z.NEEDLEMANN_WUNSCH){const t=Array.from(a.keys()),e=await(0,bt.A7)(t,n),i={};Object.entries(e.alphabetIndexes).forEach((([t,e])=>{i[a.get(t)]=e}));const r=o.reduce(((t,e)=>Math.max(t,e.length)),0);h={scoringMatrix:e.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:h}}var pe=n(8115);function me(t){const e=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(t.seqCol.name),s.divText(t.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",e.append(n),t.points.forEach((n=>{const i=s.divText(t.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",e.append(s.divV([s.divText(t.seqCol.get(n)),i]))})),e}function fe(t){const e=s.div();e.append(s.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);t.points.forEach(((e,i)=>{n[i]=t.activityCol.get(e)}));const i={},r=Di.seqHelper.getSeqHandler(t.seqCol),o=r.defaultBiotype,a=ye(r.getSplitted(t.points[0]),r.getSplitted(t.points[1]),o,i);return e.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),e.append(be(i)),e.append(ge("Activity delta",Math.abs(n[0]-n[1]))),e.append(ge("Cliff",t.sali)),e}function ge(t,e){return s.divH([s.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function ye(t,e,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");r.height=30;const s=Di.monomerLib;return Xt(o,0,0,0,30,rt().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),rt().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),n,s,!0,i),r}function be(t){const e=s.div();if(Object.keys(t).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(n)}return e}function ve(t,e){const n=a.Column.string("seq_diff",t.rowCount).init((n=>`${t.get(e[0],n)}#${t.get(e[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=t.col(e[0]).meta.units,n.setTag(gt.gp.separator,t.col(e[0]).getTag(gt.gp.separator)),t.columns.add(n);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}class we extends a.JsViewer{constructor(t,e){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...e?{semType:e}:{}}),this.name=t,this.semType=e}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>{this.gridSelect||this.render(t)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("targetColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===this.semType&&(this.targetColumn=e)}this.debouncedRender()}}debouncedRender(t=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(t),this.debounceTimer=null}),100)}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class Ce extends we{distanceMetric;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];tags=[a.TAGS.UNITS,gt.gp.aligned,gt.gp.separator,gt.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;constructor(t,e){super(t,e),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS})}async onTableAttached(){super.onTableAttached(),this.dataFrame&&(this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3)}}const Ae={gapPenalty:1,matchScore:1,gapSymbol:wt.b9[wt.Hi.FASTA],localAlignment:!1};class Se extends Ce{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;constructor(t,e){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.targetColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(t,this.idxs.length).init((t=>this.targetColumn?.get(this.idxs?.get(t)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.targetColumn.getTag(t))));const e=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;e.onCurrentRowChanged.subscribe((t=>{n&&clearTimeout(n),(e.currentRowIdx??-1)<0||(this.dataFrame.currentRowIdx=e.col("indexes").get(e.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(e)}),300),this.gridSelect=!0)})),this.analysisGrid?(this.analysisGrid.dataFrame=e,this.analysisGrid.invalidate()):(this.analysisGrid=e.plot.grid(),(0,$t.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,$t.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}async computeByMM(){const t=this.targetColumn.length,e=Math.min(this.limit,t-1);if(!this.knn||this.kPrevNeighbors!==e){const n=(await de(this.targetColumn,ue.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=e,this.knn=await(new H).getKNN(n,ue.Z.LEVENSHTEIN,Math.min(this.limit,t-1))}const n=new Array(e).fill(0).map(((t,e)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][e],score:1-this.knn.knnDistances[this.targetMoleculeIdx][e]})));n.sort(((t,e)=>e.score-t.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",e+1).init((t=>n[t].idx)),this.scores=a.Column.float("score",e+1).init((t=>n[t].score))}createPropertyPanel(t){const e=s.div(),n={},i=this.molCol?.name,r=t.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(r),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(t.currentRowIdx),u=function(t,e,n={}){const i={...Ae,...n},r=t.length,o=e.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(t.getCanonical(n-1)===e.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,h=i.localAlignment?l[1]:o,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(t.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(e.getCanonical(h-1)),h-=1):(u.push(t.getCanonical(c-1)),d.push(e.getCanonical(h-1)),c-=1,h-=1)}u=[...rt().count(0).take(c).map((e=>t.getCanonical(e))),...u.reverse(),...i.localAlignment?rt().count(l[0]).take(r).map((e=>t.getCanonical(e))):[]],d=[...rt().count(0).take(h).map((t=>e.getCanonical(t))),...d.reverse(),...i.localAlignment?rt().count(l[1]).take(o).map((t=>e.getCanonical(t))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new kt.Mu(u,i.gapSymbol),seq2Splitted:new kt.Mu(d,i.gapSymbol)}}(c,h),d=ye(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);e.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&e.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(be(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>e),!0),o.shell.o=p.root}}var xe=n(1407);class Ee extends Ce{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;constructor(t){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=t,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.targetColumn){const t=this.seqHelper.getSeqHandler(this.targetColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,n=a.Column.string(e,this.renderMolIds.length).init((t=>this.targetColumn?.get(this.renderMolIds[t])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>n.setTag(t,this.targetColumn.getTag(t))));const i=a.DataFrame.fromColumns([n]);n.temp[".mm.cellRenderer.maxMonomerLength"]=4,i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]}));const r=i.plot.grid();(0,$t.Kd)(r,n.name,450,30),(0,$t.Ku)(this.root,r.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,xe.R)(this.targetColumn,this.seqHelper);a.DataFrame.fromColumns([t]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=(await de(this.targetColumn,ue.Z.LEVENSHTEIN)).seqList,e=new F(!0,!1),n=await e.calc(t,ue.Z.LEVENSHTEIN);e.terminate();const i=this.targetColumn.length,r=(o=i,(t,e)=>o*t+e-Math.floor((t+2)*(t+1)/2));var o;this.renderMolIds=function(t,e,n){function i(t,e){let n=null,i=null;for(const r of t){const t=e(r);(null==i||t>i)&&(n=r,i=t)}return n}const r=[(s=t-1,Math.floor(function(t){return Math.random()*t}(s)))],o=new Set;var s;for(let e=0;e<t;++e)r.includes(e)||o.add(e);for(;r.length<e;){const t=i(o.values(),(t=>Math.min.apply(Math,r.map((function(e,i){return n(t,e)})))));null!=t&&(r.push(t),o.delete(t))}return r}(i,Math.min(i,this.limit),((t,e)=>this.targetColumn.isNone(t)||this.targetColumn.isNone(e)?0:n[r(t,e)]))}}var Me,_e=n(5433),Ie=n(3890),Te=n(1687);!function(t){t.TYPE="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t[t.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",t.RGP_LINE_START="M  RGP",t.ATOM_ALIAS_LINE_START="A  ",t.END="M  END"}(Me||(Me={}));class Le{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let n=t;const i=this.isWhitespace(n)?e:e-1;for(let t=0;t<i;t++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let n=this.getAtomBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToAtomType(n),e[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[t,e,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:n}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[n]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let n=this.getBondBlockIdx();for(let i=0;i<t;i++)n=this.shiftIdxToBondType(n),e[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let n=e+1;for(;!this.isWhitespace(n);)++n;return t(this.fileContent.substring(e,n))}}class Ne extends Le{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,n=e;return this.isQuote(e)?(n=this.getNextIdenticalChar(e),e++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(e,n)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((n=this.fileContent.charCodeAt(e+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(n=this.shiftIdxToAtomType(n),t(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Pe extends Ne{constructor(t){super(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map,e=this.fileContent.split("\n");e.filter((t=>t.startsWith(Me.RGP_LINE_START))).forEach((e=>{const n=this.getAtomIdxToRgpIdxList(e);for(const[e,i]of n){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,i)}}));const n=e.map(((t,e)=>{if(t.startsWith(Me.ATOM_ALIAS_LINE_START))return e})).filter((t=>void 0!==t)),i=n.map((t=>e[t])),r=n.map((t=>e[t+1]));i.forEach(((e,n)=>{const i=parseInt(e.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(t.has(o))throw new Error(`R group ${o} is already in the map`);t.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return t}getAtomIdxToRgpIdxList(t){const e=t.split(/\s+/).filter((t=>t)).slice(3).map((t=>parseInt(t))),n=new Array(e.length/2);for(let t=0;t<e.length;t+=2)n[t/2]=[e[t+1],e[t]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((t,e)=>{if(t.includes("R#"))return e})).filter((t=>void 0!==t))}static isValidMolfile(t){return-1!==t.indexOf(Me.TYPE)&&-1!==t.indexOf(Me.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,Me.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<Me.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,Me.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,Me.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+Me.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(t,e));return t=e,e+=Me.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class $e extends Ne{constructor(t){super(t),this.init(t)}getAtomLines(){const t=this.getAtomBlockIdx(),e=this.getBondBlockIdx();return this.fileContent.substring(t,e).split("\n").slice(0,this.atomCount)}getBondLines(){const t=this.getBondBlockIdx();return this.fileContent.substring(t).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const t=new Map;return this.getAtomLines().forEach(((e,n)=>{const i=e.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const e=i[1].split(/\s+/).map((t=>parseInt(t)));if(e.length>2)throw new Error(`R group data ${e} has more than 2 elements`);const r=e[1];if(t.has(r))throw new Error(`R group ${r} is already in the map`);t.set(r,n)}})),t}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M  V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M  V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M  V30 BEGIN BOND"))}static isValidMolfile(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M  END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M  V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const n=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(t,e))}}}class Re{constructor(){}static getInstance(t){if(Re.isMolfileV2K(t))return new Pe(t);if(Re.isMolfileV3K(t))return new $e(t);throw new Error("Malformed molfile")}static isMolfileV2K(t){return Pe.isValidMolfile(t)}static isMolfileV3K(t){return $e.isValidMolfile(t)}}var Oe=n(6197),ke=n(9124),Ge=n(3527);class Fe{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(t,e,n="missing",i=void 0,r=void 0,o=void 0,s){if(this.biotype=t,this.id=e,this.n=n,this.m=i,this.type=r,this.mt=o,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++Fe.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class He extends Fe{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(t){super(t,"*","gap")}}class Be extends Fe{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(t,e){super(t,e,"ambiguous")}}class De extends Fe{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(t,e,n){super(t,e,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Ve extends Fe{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(t,e){super(t,e,"broken")}}class je{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(t,e,n,i,r,o,s,a){this.id=t,this.m=e,this.n=n,this.na=i,this.type=r,this.mt=o,this.at=s,this.smiles=a}static fromMonomer(t,e,n){let i={};const r=e.symbol,o=e.smiles;if(e.rgroups.length>0)e.rgroups.forEach((t=>{i[t.label]=t.capGroupName}));else{if(!o){if(e.lib)return new Ve(t,r);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(o)}const s=new je(e.symbol,e.molfile,e.name,e.naturalAnalog,e.polymerType,e.monomerType,i),a=n.getMonomerColors(t,e.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Ue={[Ht.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ht.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[Ht.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Ht.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Ht.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Ht.o.CHEM]:{R:"#eeeeee"},[Ht.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},We=/[\w()]+/,qe=RegExp(String.raw`\(${We}(,${We})+\)`),ze=t=>{const e=s.canvas(250,250);return o.chem.canvasMol(0,0,250,250,e,t),e},Ye=new Ge.Mi([255,255,255]),Ke=new Ge.Mi([0,0,0]),Ze=.7*(0,z.wQ)(Ye);class Xe{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(t,e){this._monomers=t,this.source=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([t,e])=>0===Object.keys(e).length));for(const[t,e]of Object.entries(this._monomers))for(const[t,n]of Object.entries(e))n.lib=this}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}addMissingMonomer(t,e){let n=this._monomers[t];n||(n=this._monomers[t]={});let i=e;return e==wt._S||e===wt.b9[wt.Hi.HELM]?i="Gap":("PEPTIDE"===t&&"X"===e||"RNA"===t&&"N"===e)&&(i="Any"),n[e]={symbol:e,name:i,molfile:"",author:"MISSING",id:-1,rgroups:rt().count(1).take(9).map((t=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${t.toString()}`}))).toArray(),smiles:"",polymerType:t,monomerType:void 0,createDate:null}}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?e[n]:null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}getWebEditorMonomer(t,e){const[n,i]=(0,ke.fA)(t,e),r=(0,Oe.Y)(n);let o=this.getMonomer(r,i);if(o&&n==Ht.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==Ht.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(r,i));let s=o.wem??null;return s||(i===wt._S||"*"==i?s=o.wem=new He(n):n===Ht.o.NUCLEOTIDE&&"N"===i||n===Ht.o.AA&&"X"===i||(Ht.o.CHEM,0)||qe.test(i)?s=o.wem=new Be(n,i):o.lib||(s=o.wem=new De(n,i,this.isEmpty)),s||(s=o.wem=je.fromMonomer(n,o,this))),s}getTooltip(t,e){const n=(0,Oe.Y)(t),i=s.div([],{classes:"ui-form ui-tooltip"}),r=this.getWebEditorMonomer(t,e),o=this.getMonomer(n,e);if(o){const t=o.symbol,[e,n,a]=(o.name,r?[r.textcolor,r.backgroundcolor,r.linecolor]:["#202020","#A0A0A0","#202020"]);let l;if(i.append(s.divH([s.div([t],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:e,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([o.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=o.molfile?ze(o.molfile):o.smiles?s.divV([ze(o.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),o.symbol!=wt._S){let t=o.lib?.source;t?(t.endsWith(".json")&&(t=t.substring(0,t.length-5)),t=t.replace(/_/g," ").replace(/-/g," ").replace(/([a-z])([a-z])([A-Z])/g,"$1$2 $3"),i.append(s.divText(t))):i.append(s.divText("Missed in libraries"))}}else i.append(s.divV([s.divText(`Monomer '${e}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(t,e){const n=this.getMonomerColors(t,e),i=t=>{const e=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(t);if(e)return[parseInt(e[1]),parseInt(e[2]),parseInt(e[3])];const n=a.Color.fromHtml(t);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},r=i(n.textcolor),o=new Ge.Mi([...r.map((t=>t+1))]),s=(0,z.KE)(o,Ye)/((0,z.wQ)(o)*(0,z.wQ)(Ye)),l=i(n.backgroundcolor),c=new Ge.Mi([...l.map((t=>t+.01))]);let h;h=(0,z.KE)(c,Ye)/((0,z.wQ)(c)*(0,z.wQ)(Ye))<s?l:r;let u=new Ge.Mi(h);const d=(0,z.wQ)(u);return d>Ze&&(u=(0,z.dC)(Ke,u,Ze/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(t,e){const n="default";let i=n;const r=(0,Oe.Y)(t),o=this.getMonomer(r,e);let s;if(o){if(o.meta&&o.meta.colors){const t=o.meta.colors;n in t||(i="default"),s=t[i]}if(!s){const e=Ue[t],n=e?.[o.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const e=o.naturalAnalog;if(!s&&e)return this.getMonomerColors(t,e)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(t){const e=t.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,r="";if(e)for(let t=0;t<e.length;t++)if(null!=e[t]&&/\d/.test(e[t])){i=e[t][e[t].length-1],e[t]=e[t].replace(/[0-9]/g,"");for(let n=0;n<e[t].length;n++)":"!=e[t][n]&&(r+=e[t][n]);n["R"+i]=r,r=""}return n}}var Je=n(5488),Qe={};Qe.styleTagTransform=A(),Qe.setAttributes=b(),Qe.insert=g().bind(null,"head"),Qe.domAPI=m(),Qe.insertStyleElement=w(),d()(Je.A,Qe),Je.A&&Je.A.locals&&Je.A.locals;class tn extends Xe{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(t,e,n=void 0){super(t,e),this.error=n}toJSON(){const t=[];for(const e of Object.values(this._monomers))for(const n of Object.values(e))t.push({...n,lib:void 0,wem:void 0});return t}getMonomer(t,e){let n=e;"RNA"==t&&"R"==n&&(n="r"),"RNA"==t&&"P"==n&&(n="p");let i=null;if(t){const e=this._monomers[t];i=e?.[n]??null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${e}', polymerType not specified.`);for(const[t,e]of Object.entries(this._monomers))if(i=e[n],i)break}return i}_monomerSets=null;getMonomerSet(t){const e=(0,Oe.Y)(t);if(this._monomerSets||(this._monomerSets={}),!(t in this._monomerSets))for(const[t,n]of Object.entries(this._monomers[e]));return this._monomerSets[t]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((n=>{e[n]=this._monomers[t][n].molfile})),e}getMonomerSymbolsByRGroup(t,e,n){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let n=e?.rgroups.length>=t;var i;return i=Re.getInstance(e.molfile).atomTypes,i.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),n&&=!0,n})),i.map((t=>t?.symbol)))}_updateLibInt(t){const e=t.getPolymerTypes(),n=this.getPolymerTypes();e.forEach((e=>{n.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((n=>{this._monomers[e][n]&&(this._duplicateMonomers[e]??={},this._duplicateMonomers[e][n]??=[this._monomers[e][n]],this._duplicateMonomers[e][n].push(t.getMonomer(e,n))),this._monomers[e][n]=t.getMonomer(e,n)}))})),this._isEmpty=this.isEmpty&&t.isEmpty}updateLibs(t,e=!1){e&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const e of t)e.error||this._updateLibInt(e);Object.entries(this.duplicateMonomers).length>0?(0,Nt.ub)().then((t=>{this.assignDuplicatePreferences(t)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(t){let e=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(t.duplicateMonomerPreferences?.[n]?.[i]){const r=t.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((t=>t.lib?.source===r));o?this._monomers[n][i]=o:e=!1}else e=!1;return this._duplicatesHandled=e,e}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const t={},e=this.getPolymerTypes();for(const n of e)t[n]=this.getMonomerSymbolsByType(n).length;return t}getSummaryDf(){const t=this.getPolymerTypes(),e=new Array(t.length);for(const[n,i]of rt().enumerate(t))e[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",t),a.Column.fromList(a.COLUMN_TYPE.INT,"count",e)])}getSummary(){const t=this.getPolymerTypes();return 0==t.length?"empty":t.map((t=>`${t} ${this.getMonomerSymbolsByType(t).length}`)).join("\n")}static overrideCounter=0;override(t,e){return new en(t,`override: ${++tn.overrideCounter}, ${e}`,this)}}class en extends Xe{data;base;constructor(t,e,n){super(t,e),this.data=t,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(t){const e=this.base.getMonomerSymbolsByType(t);for(const n of Object.keys(this.data[t]??{}))e.includes(n)||e.push(n);return e}addMissingMonomer(t,e){return this.base.addMissingMonomer(t,e)}getMonomer(t,e){const n=this.data[t]?.[e];return n??this.base.getMonomer(t,e)}}class nn{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(t,e,n,i,r){this.monomerLib=t,this.symbol=e,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((t=>{const n=this.monomerLib.getMonomer(this.polymerType,t.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=t.source)throw new Error(`Monomer '${e}' found in different library.`);return n}))}catch(t){const[e,n]=(0,Ct.AP)(t);this.error=e,this.monomers=[]}}}class rn{description;placeholders;source;error;constructor(t,e,n=void 0,i=void 0){this.description=t,this.placeholders=e,this.source=n,this.error=i}updateSets(t,e=!1){e&&(this.placeholders=[]);for(const e of t)e.error||this._updateSetInt(e)}_updateSetInt(t){for(const e of t.placeholders)this.placeholders.push(e)}}var on=n(7433),sn=n.n(on),an=n(1913),ln=n.n(an);class cn{helmMonomerSchema;validateMonomerSchema;constructor(t){this.helmMonomerSchema=t;const e=new(sn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});ln()(e),this.validateMonomerSchema=e.compile(this.helmMonomerSchema)}validateFile(t,e){const n=this.parseJson(t,e);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,e):(console.warn(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(t,e){try{return JSON.parse(t)}catch(t){return console.error(`Bio: Monomer Library File Validator file '${e}': Invalid JSON format:`,t),null}}validateJsonContent(t,e){let n=!0;const i=new Set;for(const r of t){const t=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' violating JSON schema:`,r,"\nError reason: ",JSON.stringify(this.validateMonomerSchema.errors??{}),`\nThere may be other errors in ${e} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${t}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${e}, monomer '${t}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}var hn=n(8604);class un{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(t,e,n,i){let r;this.fileValidator=t,this.libHelper=e,this.eventManager=n,this.logger=i;let o=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((t=>r=t))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),o||(o=!0,r())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++un.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(t,e,n){const i=await o.dapi.files.readAsText(hn.gt),r=JSON.parse(i),s=new cn(r);return new un(s,t,e,n)}async addLibraryFile(t,e,n=!0){try{if(await o.dapi.files.exists(hn.so+`${e}`))return void o.shell.error(`File ${e} already exists`);await this.validateAgainstHELM(t,e),await o.dapi.files.writeAsText(hn.so+`${e}`,t),await this.updateValidLibList(),await o.dapi.files.exists(hn.so+`${e}`)?o.shell.info(`Added ${e} HELM library`):o.shell.error(`Failed to add ${e} library`)}catch(t){console.error(t),o.shell.error(`Failed to add ${e} library`)}}async deleteLibraryFile(t){try{await o.dapi.files.delete(hn.so+`${t}`),await this.updateValidLibList(),o.shell.info(`Deleted ${t} library`)}catch(e){console.error(e),await o.dapi.files.exists(hn.so+`${t}`)?o.shell.error(`Failed to delete ${t} library`):o.shell.warning(`File ${t} already deleted, refresh the list`)}}async loadLibraryFromFile(t,e){let n=[];const i=new a.FileSource(t),r=await i.readAsText(e);n=JSON.parse(r);const o={},s=[];return n.forEach((t=>{const e=t.polymerType,n=t.symbol;s.includes(e)||(o[e]={},s.push(e)),o[e][n]=t})),new tn(o,e)}async loadSetFromFile(t,e,n){let i={};const r=new a.FileSource(e),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([e,n])=>{const i=e,r=n.polymerType,o=n.monomerType,s=n.set;return new nn(t,i,r,o,s)}));return new rn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const t=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${t}, end, not changed`);for(const t of n){if(!t.endsWith(".json")){e.push(t);continue}const n=await o.dapi.files.readAsText(hn.so+`${t}`);this.isValidHELMLibrary(n,t)||e.push(t)}const i=n.filter((t=>!e.includes(t)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((t=>!t.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),e.length>0){const t=`Invalid monomer library files in ${hn.so}, consider fixing or removing them: ${e.join(", ")}`;this.logger.warning(t)}this.logger.debug(`${t}, OUT`)})),this.logger.debug(`${t}, end`),this.filesPromise}async updateValidSetList(){const t=`${this.toLog()}.updateValidSetList()`;return Di.logger.debug(`${t}, start`),this.filesPromise=this.filesPromise.then((async()=>{Di.logger.debug(`${t}, IN`);const e=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Di.logger.debug(`${t}, end, not changed`);for(const t of n)t.endsWith(".json")?await o.dapi.files.readAsText(hn.Es+`${t}`):e.push(t);const i=n.filter((t=>!e.includes(t)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Di.logger.debug(`${t}, OUT`)})),Di.logger.debug(`${t}, end`),this.filesPromise}libListHasChanged(t){const e=this.eventManager.getValidLibPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}setListHasChanged(t){const e=this.eventManager.getValidSetPathList();return t.length!==e.length||t.some(((t,n)=>t!==e[n]))}async validateAgainstHELM(t,e){if(!this.isValidHELMLibrary(t,e))throw new Error(`File ${e} does not satisfy HELM standard`)}isValidHELMLibrary(t,e){return this.fileValidator.validateFile(t,e)}async getLibFileListAtLocation(){const t=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await o.dapi.files.list(hn.so).then((t=>t.filter((t=>t.isFile)).map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(hn.so.length)))}async getSetFileListAtLocation(){const t=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${t}, start`);const e=await o.dapi.files.list(hn.Es).then((t=>t.map((t=>t.fullPath)))),n=[];return n.push(...e),n.map((t=>t.substring(hn.Es.length)))}}class dn{constructor(){}static _instance;static getInstance(){return dn._instance||(dn._instance=new dn),dn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((t=>{const e=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{t(n),e.unsubscribe()}))}))}changeValidLibPathList(t){this._libFilesUpdateSubject$.next(t)}changeValidSetPathList(t){this._setFilesUpdateSubject$.next(t)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(t,e){this._librarySelectionSubject$.next([t,e])}}class pn{logger;_monomerLib=new tn({},"MAIN");_monomerSets=new rn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(t=1/0){return t=t===1/0?6e4:t,await Promise.race([(async()=>{const t=await this.getFileManager();return await t.filesPromise,!0})(),(async()=>(await(0,te.cb)(t),!1))()]).then((e=>{if(!e)throw new Error(`Loading monomer libraries timeout ${t} ms.`)}))}constructor(t){this.logger=t}static objCounter=-1;objId=(()=>{if(++pn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return pn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(t){this._monomerLib.assignDuplicatePreferences(t)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const t=await un.create(this,this._eventManager,this.logger);return await t.initializedPromise,t})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(t=!1){const e=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${e}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[e],i]=await Promise.all([await this.getFileManager().then((t=>[t.getValidLibraryPaths()])),(0,Nt.ub)()]),r=e.filter((t=>{const e=!i.exclude.includes(t),n=0===i.explicit.length||i.explicit.includes(t);return e&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((t=>this.readLibrary(hn.so,t).catch((e=>{const n=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn({},t,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,t),this._initialLoadCompleted=!0}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;o.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{n.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadLibrariesPromise}async loadLibraries(t){return this.loadMonomerLib(t)}loadSetsPromise=Promise.resolve();async loadMonomerSets(t=!1){const e=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${e}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[e]]=await Promise.all([await this.getFileManager().then((t=>[t.getValidSetPaths()]))]),n=e.filter((t=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((e=>this.readSet(hn.Es,e).catch((t=>{const n=`Loading monomer sets from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new rn("Broken monomer set",[],e,n)})).finally((()=>{t.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(t){const e=`Loading monomer sets error: ${t instanceof Error?t.message:t.toString()}`;o.shell.warning(e);const n=t instanceof Error?t.stack:void 0;this.logger.error(e,void 0,n)}finally{t.close(),this.logger.debug(`${e}, OUT`)}})),this.logger.debug(`${e}, end`),this.loadSetsPromise}async readLibrary(t,e){const n=await this.getFileManager();return await n.loadLibraryFromFile(t,e)}async readSet(t,e){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,t,e)}async selectSpecifiedLibraries(t){const e=await this.getInvalidFileNames(t);if(e.length>0)throw new Error(`Cannot select libraries ${e}: no such library in the list`);const n=await(0,Nt.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((e=>!t.includes(e))),await(0,Nt.Eu)(n)}async getInvalidFileNames(t){const e=(await this.getFileManager()).getValidLibraryPaths();return t.filter((t=>!e.includes(t)))}async loadMonomerLibForTests(){await(0,Nt.Eu)(hn.G3),await this.awaitLoaded(1e4),await this.loadMonomerLib(!0)}static async getInstance(){let t=window.$monomerLibHelperPromise;return null==t&&(t=window.$monomerLibHelperPromise=(async()=>{const t=new pn(Di.logger);return t._eventManager=dn.getInstance(),t})()),t}}var mn=n(1757),fn=n.n(mn),gn=n(3017),yn={};yn.styleTagTransform=A(),yn.setAttributes=b(),yn.insert=g().bind(null,"head"),yn.domAPI=m(),yn.insertStyleElement=w(),d()(gn.A,yn),gn.A&&gn.A.locals&&gn.A.locals;var bn=n(3151);class vn{constructor(t,e=[],n={}){this.onItemChanged=new h.Subject,this.onAddingItemChanged=new h.Subject,this.onItemAdded=new h.Subject,this.onItemRemoved=new h.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.addingItemInputs={},this.properties=t,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=e,this.render()}get root(){return this._root}get items(){return this._items}set items(t){this._items=t,this.render()}addItem(t,e=!0){this._items.push(t),this.render(),e&&this.onItemAdded.next(t)}removeItem(t,e=!0){-1!==this._items.indexOf(t)&&(this._items.splice(this._items.indexOf(t),1),this.render(),e&&this.onItemRemoved.next(t))}removeAtIndex(t,e=!0){if(t<0||t>=this._items.length)return;const n=this._items.splice(t,1);this.render(),e&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var t,e,n,i,r;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(t=n.caption)&&void 0!==t?t:n.name;(null===(e=this.options.customLabels)||void 0===e?void 0:e[n.name])&&(i=this.options.customLabels[n.name]);const r=s.divText(i);r.style.fontWeight="bold",this._root.appendChild(r)}for(const t of this._items){const e=this.getItemDiv(t);for(const t of e)this._root.appendChild(t)}if(this.options.allowAdd){const t=this.getItemDiv(null!==(r=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==r?r:void 0,!0);for(const e of t)this._root.appendChild(e)}}get addingItem(){const t={};return Object.keys(this.addingItemInputs).forEach((e=>{t[e]=this.addingItemInputs[e].value})),t}getItemDiv(t={},e){var n,i;const r=[],o={};let l=null;for(const c of this.properties){void 0===t[c.name]&&(t[c.name]=null);const h=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](t):s.input.forProperty(c,t),u=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];u&&h.addValidator(u),r.push(this.options.horizontalInputNames?h.root:this.hideLabel(h.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&h.input&&(h.input.style.width="100%"),o[c.name]=h,h.onChanged.subscribe((()=>{t[c.name]=h.value,e?this.onAddingItemChanged.next({item:t,fieldName:c.name}):this.onItemChanged.next({item:t,fieldName:c.name})})),h.root.style.alignItems="center",l=h}let c=null;if(e)this.addingItemInputs=o,c=s.icons.add((()=>{const t=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(o).forEach((e=>{t[e]=o[e].value})),this._items.push(t),this.onItemAdded.next(t),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return r;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(t),1),this.onItemRemoved.next(t),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",r}hideLabel(t){return t.getElementsByTagName("label")[0]&&t.removeChild(t.getElementsByTagName("label")[0]),t}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const wn={A:new V.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new V.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new V.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new V.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new V.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new V.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new V.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new V.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new V.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new V.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new V.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new V.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},Cn={RNA:{A:new V.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new V.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new V.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:wn};async function An(t,e,n=0){if(!Object.keys(Cn).includes(e))return null;const i=await async function(t){const e=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!e)return null;try{const n=(await e.apply({molString:t}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(t){return null}}(t);if(!i)return null;if(!Cn[e])return null;const r=Cn[e];let o=0,s=null;for(const[t,e]of Object.entries(r)){const r=(0,O.$1)(i,e);r>o&&r>=n&&(o=r,s=t)}return s}var Sn,xn=n(857),En={};En.styleTagTransform=A(),En.setAttributes=b(),En.insert=g().bind(null,"head"),En.domAPI=m(),En.insertStyleElement=w(),d()(xn.A,En),xn.A&&xn.A.locals&&xn.A.locals,function(t){t.MONOMER="Monomer",t.SYMBOL="Symbol",t.NAME="Name",t.R_GROUPS="~R-Groups",t.MONOMER_TYPE="Monomer Type",t.POLYMER_TYPE="Polymer Type",t.NATURAL_ANALOG="Natural Analog",t.AUTHOR="Author",t.CREATE_DATE="Create Date",t.ID="ID",t.META="Meta",t.SOURCE="Source"}(Sn||(Sn={}));const Mn={[Sn.MONOMER]:a.COLUMN_TYPE.STRING,[Sn.SYMBOL]:a.COLUMN_TYPE.STRING,[Sn.NAME]:a.COLUMN_TYPE.STRING,[Sn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Sn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Sn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Sn.AUTHOR]:a.COLUMN_TYPE.STRING,[Sn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Sn.ID]:a.COLUMN_TYPE.INT,[Sn.META]:a.COLUMN_TYPE.STRING,[Sn.SOURCE]:a.COLUMN_TYPE.STRING};class _n{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Sn.NAME).width=100,this.tv.grid.col(Sn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=bn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(t){this.monomerLibManamger=t,this.monomerLib=t.getBioLib(),this._newMonomerForm=new Pn(t,(()=>this.activeMonomerLib),(async t=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e,this.adjustTable(),null!=t&&setTimeout((()=>{const n=e.col(Sn.SYMBOL).toList().indexOf(t);-1!==n&&(this.tv?.grid.scrollToCell(e.columns.byIndex(0),n),e.currentRow=e.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const t=await pn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.instance=new _n(t)}return this.instance}static async getNewInstance(){const t=await pn.getInstance();return await t.awaitLoaded(),await t.loadLibrariesPromise,new _n(t)}async createNewMonomerLib(t,e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(e.map((t=>({...t,lib:void 0,wem:void 0}))),null,2);t.endsWith(".json")||(t+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,t),await o.dapi.files.writeAsText(hn.so+t,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(t)}catch(t){o.shell.error("Error creating library"),console.error(t)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(t){const e=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const t=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!t)}});function i(t){return t&&t.trim()?t.endsWith(".json")&&e.includes(t)||e.includes(t+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const e=i(n.value);if(e)o.shell.warning(e);else{try{await this.createNewMonomerLib(function(){let t=n.value;return t.endsWith(".json")||(t+=".json"),t}(),t??[])}catch(t){o.shell.error("Error creating library"),console.error(t)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(t,e=!0){const n=await this.getMonomersDf(t);return this.tv=a.TableView.create(n,e),this.adjustTable(),this.tv.subs.push(o.events.onContextMenu.subscribe((({args:t})=>{if(!t||!t.menu||!t.context||t.context.type!==a.VIEWER.GRID||!t.context.tableView||t.context.tableView.id!==(this.tv.id??"")||!t.item||!t.item.isTableCell||(t.item.tableRowIndex??-1)<0)return;const e=t.item.tableRowIndex;t.menu.item("Edit Monomer",(async()=>{await this.editMonomer(this.tv.dataFrame.rows.get(e))})),this.tv.dataFrame.selection.trueCount>0?(t.menu.item("Remove Selected Monomers",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>Gn(this.tv.dataFrame.rows.get(t)))));this._newMonomerForm.removeMonomers(t,this.libInput.value)})),t.menu.item("Selection To New Library",(async()=>{const t=await Promise.all(Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((t=>Gn(this.tv.dataFrame.rows.get(t)))));this.createNewLibDialog(t)}))):t.menu.item("Remove Monomer",(async()=>{const t=await Gn(this.tv.dataFrame.rows.get(e));this._newMonomerForm.removeMonomers([t],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter((t=>t.name===_n.VIEW_NAME)).forEach((t=>t.close()))}findActiveManagerView(){if(!this.tv)return null;const t=Array.from(o.shell.tableViews??[]).find((t=>t.id===this.tv.id));return t?o.shell.v=t:_n.closeAllMonomerManagers(),t??null}_skipLibInputOnchange=!1;async getViewRoot(t,e=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),e&&(this.tv=this.findActiveManagerView())&&(t??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),t&&(this.libInput.value=t)}catch(t){o.shell.error("Error updating library list"),console.error(t)}finally{this._skipLibInputOnchange=!1}const e=await this.getMonomersDf(t);return this.tv.dataFrame=e,this.adjustTable(),this.tv}t??=n[0],this.tv=await this.getMonomersTableView(t,e);let i=this.tv.getRibbonPanels();i.forEach(((t,e)=>{i[e]=t.filter((t=>0!==t.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((t=>t.length>0));const r=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.icons.edit((async()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||await this.editMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),c=s.icons.delete((async()=>{const t=this.tv?.dataFrame?.currentRowIdx??-1,e=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(t<0&&0===e.length)return;if(e.length>0){const t=await Promise.all(e.map((t=>Gn(this.tv.dataFrame.rows.get(t)))));return void await this._newMonomerForm.removeMonomers(t,this.libInput.value)}const n=await Gn(this.tv.dataFrame.rows.get(t));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(c,(()=>(this.tv?.dataFrame?.selection?.trueCount??0)>0?"Delete selected monomers":"Delete monomer"));const h=s.iconFA("arrow-to-bottom",(async()=>{const t=this.libInput.value;if(!t)return o.shell.error("No library selected");let e=null;try{e=await o.dapi.files.readAsText(hn.so+t)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}if(!e)return o.shell.error(`Library ${t} is empty`);a.Utils.download(t,e,"text/plain")}),"Download Monomer Library");i.push([r,l,c,h]),this.tv.setRibbonPanels(i),this.tv.name=_n.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:t,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const t=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=t,this.adjustTable()}catch(t){console.error(t)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const u=this._newMonomerForm.form;return u.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(u,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}async editMonomer(t){return this._newMonomer=await Gn(t),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(t??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(hn.so,t),!this.activeMonomerLib)return o.shell.error(`Library ${t} not found`),a.DataFrame.create();const e=this.activeMonomerLib.getPolymerTypes().flatMap((t=>this.activeMonomerLib.getMonomerSymbolsByType(t).map((e=>this.activeMonomerLib.getMonomer(t,e))))),n=a.DataFrame.create(e.length),i=new Set;for(const t of e)t.rgroups.forEach((t=>{t.label&&i.add(t.label)}));const r=Array.from(i);r.sort();for(const[t,e]of Object.entries(Mn))if(n.columns.addNew(t,e),t===Sn.R_GROUPS)for(const t of r)n.columns.addNew(t,a.COLUMN_TYPE.STRING);n.col(Sn.SYMBOL).semType="Monomer",n.col(Sn.SYMBOL).setTag(Rt.Mn.applyToBackground,"true");for(let t=0;t<e.length;t++){let i=Rn(e[t].rgroups,e[t].smiles,e[t].molfile);i=In(i),e[t].rgroups=Nn(e[t].rgroups);const o=r.map((n=>{const i=e[t].rgroups.find((t=>t.label===n));return i?Ln(i,"capGroupSmiles"):""}));let s=null;if(e[t].createDate)try{s=Date.parse(e[t].createDate)}catch(n){console.error(`Error parsing date ${e[t].createDate}`)}n.rows.setValues(t,[i,e[t].symbol,e[t].name,JSON.stringify(e[t].rgroups??[]),...o,e[t].monomerType,e[t].polymerType,e[t].naturalAnalog,e[t].author,s,e[t].id,JSON.stringify(e[t].meta??{}),e[t].lib?.source??""]);try{s&&n.col(Sn.CREATE_DATE)?.set(t,s,!1)}catch(n){console.error(`Error setting date ${e[t].createDate}`)}}return n.col(Sn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((t=>{n.col(t).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((async t=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;await this.editMonomer(n.rows.get(n.currentRowIdx))}catch(t){console.error(t)}})),n}catch(t){throw o.shell.error("Error creating monomers dataframe"),console.error(t),t}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function In(t){let e=t.replaceAll(/\[R[1-9]\]/g,(t=>`[*:${t[2]}]`));return e=e.replaceAll(/\[\d\*\]/g,(t=>`[*:${t[1]}]`)),e.replaceAll(/\[\d\*\:\d\]/g,(t=>`[*:${t[1]}]`))}const Tn=["alternateId","capGroupName","capGroupSMILES","label"];function Ln(t,e){const n=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));if(n)return t[n]}function Nn(t){return t.map((t=>{const e=function(t,e){const n={};return t.forEach((t=>{const i=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));i&&(n[t]=e[i])})),n}(Tn,t),n=Ln(e,"capGroupSMILES"),i=Ln(e,"alternateId"),r=Ln(e,"capGroupName"),o=Ln(e,"label")??"R1";if(n&&i&&r||o.length<2)return e;if(i&&-1!==i.indexOf(`${o}-`)){const t=i.replace(`${o}-`,"");r||(e.capGroupName=t),n||(e.capGroupSMILES=`[*:${o.substring(1)}][${t}]`)}else r&&(n||(e.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(e.alternateId=`${o}-${r}`));return e})).sort(((t,e)=>t.label?.localeCompare(e.label??"")??0))}class Pn{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(t){this._molChanged=t}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(t,e,n,i){this.monomerLibManager=t,this.getMonomerLib=e,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new Fn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const t=this.validateInputs();t?o.shell.warning(t):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));t&&t.header.style.removeProperty("background-color");let e=this.molSketcher.getSmiles();if(!e)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();e=Rn([],e);const n=this.findRgroupsInSmiles(e);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((t=>t[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",t&&t.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((t=>Number.parseInt(t[0].match(/[1-9]/g)[0]))).map((t=>this.rgroupsGrid.items.find((e=>e.label===`R${t}`))??{capGroupSMILES:`[*:${t}][H]`,alternateId:`R${t}-H`,capGroupName:"H",label:`R${t}`}));this.rgroupsGrid.items=i.sort(((t,e)=>t.label?.localeCompare(e.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const r=await An(kn(e,i),this.polymerTypeInput.value??"");r&&(this.monomerNaturalAnalogInput.value=r)}catch(t){console.error(t)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new vn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:t=>t?o.chem.checkSmiles(t)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:t=>t?null:"Alternate ID is required",capGroupName:t=>t?null:"Cap group name is required",label:t=>t?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new vn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const t=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=t?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(t){this.triggerMolChange=!1,this.molSketcher.setSmiles(t.smiles),this.polymerTypeInput.value=t.polymerType,this.monomerTypeInput.value=t.monomerType,this.monomerSymbolInput.value=t.symbol,this.monomerNameInput.value=t.name,this.monomerIdInput.value=t.id,this.monomerNaturalAnalogInput.value=t.naturalAnalog??null,this.rgroupsGrid.items=Nn(t.rgroups),this.metaGrid.items=Object.entries(t.meta??{}).filter((([t,e])=>"colors"!==t?.toLowerCase())).map((([t,e])=>({Property:t,Value:e}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),!t.naturalAnalog&&t.polymerType&&An(kn(t.smiles,this.rgroupsGrid.items),t.polymerType).then((t=>{t&&(this.monomerNaturalAnalogInput.value=t)}));const e=t.meta?.colors??"";let n={};try{n=e?JSON.parse(e)?.default:{}}catch(t){console.error(t)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const t=this.inputsTabControl.panes.find((t=>"r-groups"===t.name?.toLowerCase()));if(t&&t.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const t of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==t.value||""===t.value)return`${t.caption} field is required`;let e=null;if(this.rgroupsGrid.items.length<1&&(e="At least one R-group is required"),!e)t:for(const t of this.rgroupsGrid.items)for(const[n,i]of Object.entries(t))if(!i){e=`R-group ${n} field is required for ${t.label}`;break t}return!e&&this.rgroupsGrid.hasErrors()&&(e="R-group fields contain errors"),e?(t&&t.header.style.setProperty("background-color","#ff000030"),e):null}findRgroupsInSmiles(t){return[...Array.from(t.matchAll(/\[[1-9]\*\]/g)),...Array.from(t.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const t=s.buttonsInput([this.saveButton]);return s.tooltip.bind(t,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,t],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll",maxWidth:"unset"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(t){const e=Rn(t.rgroups,t.smiles,t.molfile),n=o.chem.drawMolecule(e,150,150),i=s.tableFromMap({name:t.name,author:t.author,createDate:t.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(t,e,n=!0){let i=[];try{const t=await o.dapi.files.readAsText(hn.so+e);i=JSON.parse(t)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}const r=t.map((t=>$n(i,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${t[n].symbol} not found in library ${e}`);const a=r.map((t=>i[t])),l=s.divV(a.map((t=>this.getMonomerInfoTable(t))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((t=>t.symbol)).join(", ")} from ${e} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${e} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((t=>!a.includes(t))),await o.dapi.files.writeAsText(hn.so+e,JSON.stringify(i,null,2)),await(await pn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((t=>t.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${e} library`),u.close()})).show()}async addMonomerToLib(t,e){let n=[];try{const t=await o.dapi.files.readAsText(hn.so+e);n=JSON.parse(t)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}const i=$n(n,(e=>e.symbol===t.symbol&&e.polymerType===t.polymerType)),r=this.getMonomersDataFrame()?.col(Sn.MONOMER)?.toList()?.findIndex((e=>e===t.smiles)),a=async()=>{try{const i=n.findIndex((e=>e.symbol===t.symbol&&e.polymerType===t.polymerType));i>=0?n[i]={...t,lib:void 0,wem:void 0}:n.push({...t,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText(hn.so+e,JSON.stringify(n,null,2)),await(await pn.getInstance()).loadLibraries(!0),await this.refreshTable(t.symbol),this._molChanged=!1,o.shell.info(`Monomer ${t.symbol} was successfully saved in library ${e}`)}catch(t){o.shell.error("Error saving monomer"),console.error(t)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${t.symbol}' already exists in library ${e}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const t=await Gn(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(t),c=`Monomer with the same structure already exists in library ${e} with different symbol (${t.symbol}).\nAre you sure you want to duplicate it?`}if(l){const t=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{t.close(),a()})).show()}else await a()}async saveMonomer(){let t=this.molSketcher.getSmiles();if(!t||!o.chem.checkSmiles(t))return void o.shell.warning("Invalid SMILES");t=Rn([],t);let e=o.chem.convert(t,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);e=On(e);const n={};this.metaGrid.items.filter((t=>!!t.Property&&!!t.Value)).forEach((t=>{n[t.Property]=t.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:e,smiles:t,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(r,s):o.shell.warning("Monomer library source is not specified")}}function $n(t,e){let n=-1;for(let i=t.length-1;i>=0;i--)if(e(t[i])){n=i;break}return n}function Rn(t,e,n){const i=!e||!o.chem.checkSmiles(e);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):e;return r=function(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=new RegExp(`\\[\\${t.capGroupName}:${e}\\]`,"g");n=n.replace(i,`[*:${e}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(t=>`[*:${t[1]}]`)),n}(r,t),r=In(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function On(t){const e=t.split("\n"),n=e.findIndex((t=>t.startsWith("M")&&t.includes("ISO")));if(-1!==n){const t=e[n].indexOf("ISO");e[n]=e[n].substring(0,t)+"RGP"+e[n].substring(t+3)}const i=e.findIndex((t=>t.includes("V2000")||t.includes("V3000"))),r=Number.parseInt(e[i].trim().split(" ")[0]),o={};for(let t=i+1;t<i+1+r;t++){const n=e[t].indexOf("R ");if(-1===n)continue;"#"!==e[t][n+1]&&(e[t]=e[t].replace("R ","R#"));const r=e[t].trim().split(" ").map((t=>t.trim())).filter(Boolean);if(o[t-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[t-i]=s)}const s=Object.keys(o);if(-1===e.findIndex((t=>t.startsWith("M")&&t.includes("RGP")))){const t=`M  RGP${s.length.toString().padStart(3," ")}${Object.entries(o).map((([t,e])=>`${t.toString().padStart(4," ")}${e.toString().padStart(4," ")}`)).join("")}`,n=e.findIndex((t=>t.startsWith("M")&&t.includes("END")));e.splice(n,0,t)}return s.filter((t=>!!Number.parseInt(t))).map((t=>Number.parseInt(t)+i)).forEach((t=>{const n=e[t].split(" "),i=n.findIndex((t=>"R#"===t));if(-1!==i){for(let t=i+1;t<n.length;t++)n[t]&&1==n[t].length&&(Number.parseInt(n[t])??0)>0&&(n[t]="0");e[t]=n.join(" ")}})),e.join("\n")}function kn(t,e){let n=t;return e.forEach((t=>{const e=t.label[1]??"1",i=Ln(t,"capGroupName");n=n.replace(`[*:${e}]`,`[${i}]`)})),n}async function Gn(t){let e;try{e=JSON.parse(t.get(Sn.META)??"{}");for(const t in e)"object"==typeof e[t]&&(e[t]=JSON.stringify(e[t])),("string"!=typeof e[t]||e[t]!==a.INT_NULL.toString()&&e[t]!==a.FLOAT_NULL.toString())&&("number"!=typeof e[t]||e[t]!==a.INT_NULL&&e[t]!==a.FLOAT_NULL)||(e[t]=null)}catch(t){console.error(t)}const n=t.get(Sn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=On(i)}catch(t){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(t)}let r=t.get(Sn.NATURAL_ANALOG);const s=t.get(Sn.POLYMER_TYPE);let l=[];try{if(l=JSON.parse(t.get(Sn.R_GROUPS)??"[]"),!r&&s){const t=await An(kn(n,l),s);t&&(r=t)}}catch(t){l??=[]}return{symbol:t.get(Sn.SYMBOL),name:t.get(Sn.NAME),molfile:i,smiles:n,polymerType:s,monomerType:t.get(Sn.MONOMER_TYPE),naturalAnalog:r,id:t.get(Sn.ID),rgroups:l,meta:e,author:t.get(Sn.AUTHOR),createDate:t.get(Sn.CREATE_DATE)}}class Fn{_colors;_colorInputs;constructor(t){this._colors=t,this._colorInputs={line:s.input.color("Line",{value:t.line,onValueChanged:t=>this._colors.line=t}),background:s.input.color("Background",{value:t.background,onValueChanged:t=>this._colors.background=t}),text:s.input.color("Text",{value:t.text,onValueChanged:t=>this._colors.text=t})}}get colors(){return this._colors}set colors(t){const e={line:a.Color.toHtml(a.Color.fromHtml(t.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(t.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(t.text??"#000000"))};this._colors=e;for(const t in this._colorInputs)this._colorInputs[t].value=e[t]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Hn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(t){this._selected=t,this.root.style.border=t?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(t){this.monomer=t}render(){s.empty(this.root);const t=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(t);const e=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(e),s.tooltip.bind(e,this.monomer.name),this.monomer.lib?.source){const t=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(t),s.tooltip.bind(t,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Bn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(t,e,n,i){this.monomerSymbol=t,this.monomers=e,this.monomerCards=e.map((t=>new Hn(t)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(t,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,t),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((t=>{t.root.onclick=()=>{this.monomerCards.forEach((t=>t.selected=!1)),t.selected=!0,i(t.monomer)},n&&t.monomer===n&&(t.selected=!0),r.appendChild(t.root)}))}render(){this.monomerCards.forEach((t=>t.render()))}}class Dn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Dn._instance||(Dn._instance=new Dn,await Dn._instance.refresh(),(await pn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Dn._instance.refresh()))),Dn._instance.refresh(),Dn._instance}async refresh(){this.settings=await(0,Nt.ub)();const t=await pn.getInstance();await t.awaitLoaded(),await t.loadLibrariesPromise,this.monomers=t.duplicateMonomers,this.monomerCardRows=[];for(const e in this.monomers)for(const n in this.monomers[e]){const i=this.settings.duplicateMonomerPreferences?.[e]?.[n]??null,r=i?this.monomers[e][n].find((t=>t.lib?.source===i))??null:null;this.monomerCardRows.push(new Bn(n,this.monomers[e][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[e]=this.settings.duplicateMonomerPreferences[e]??{},this.settings.duplicateMonomerPreferences[e][n]=i.lib.source,await(0,Nt.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),t.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(t=>(this.monomerCardRows[t].render(),this.monomerCardRows[t].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>t(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const t=t=>{this.filteredMonomerRows=this.monomerCardRows.filter((e=>e.monomerSymbol.toLowerCase().includes(t.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(t=>(this.filteredMonomerRows[t].render(),this.filteredMonomerRows[t].root)))}}}constructor(){}get root(){return this._root}}async function Vn(){await qn.showDialog()}async function jn(t=!0){return await zn.showView(t)}class Un{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Un.instancePromise&&(Un.instancePromise=(async()=>{const t=new Un,e=await(0,bt.pj)();return t._fileManager=await e.getFileManager(),t._widget=await t.createWidget(),t})()),Un.instancePromise}static async reloadWidget(){const t=await Un.getInstance();t._widget=await t.createWidget()}async createWidget(){const t=await this.getWidgetContent();return(await(0,bt.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(t)}async getWidgetContent(){const t=await Wn.createControlsForm();return fn()(t).addClass("monomer-lib-controls-form"),setTimeout((()=>{t&&fn()(t)&&fn()(t).removeClass("ui-form-condensed")}),200),s.divV([t])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async t=>{const e=await t.text(),n=t.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(e,n)}catch(t){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class Wn{fileManager;userLibSettings;constructor(t,e){this.fileManager=t,this.userLibSettings=e,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([t,e])=>{this.updateLibrarySelectionStatus(e,t)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Di.logger.debug("LibraryControlsForm.createControlsForm(), start");const[t,e]=await Promise.all([(0,bt.pj)().then((t=>t.getFileManager())),await(0,Nt.ub)()]);return new Wn(t,e)._createControlsForm()}_createControlsForm(){const t=this.createLibraryControls(),e=s.wideForm(t,void 0);return fn()(e).addClass("monomer-lib-controls-form"),e}updateControlsForm(){const t=this._createControlsForm();fn()(".monomer-lib-controls-form").replaceWith(t)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((t=>this.createLibInput(t)))}createLibInput(t){const e=`${this.toLog()}.createLibInput()`;Di.logger.debug(`${e}, libFileName = '${t}', start`);const n=!this.userLibSettings.exclude.includes(t),i=s.input.bool(t,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(t,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${t}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(t))),a=s.icons.edit((async()=>{o.shell.v=await(await _n.getInstance()).getViewRoot(t)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${t}`),i.addOptions(a),i.addOptions(r),Di.logger.debug(`${e}, libFileName = '${t}', end`),i}async updateLibrarySelectionStatus(t,e){this.updateLibrarySettings(t,e),await(0,Nt.Eu)(this.userLibSettings);const n=await(0,bt.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(t,e){t?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((t=>t!==e)):this.userLibSettings.exclude.includes(e)||this.userLibSettings.exclude.push(e)}promptForLibraryDeletion(t){s.dialog("Warning").add(s.divText(`Delete file ${t}?`)).onOK((async()=>{try{const e=a.TaskBarProgressIndicator.create(`Deleting ${t} library`);await this.updateLibrarySelectionStatus(!1,t),await this.fileManager.deleteLibraryFile(t),e.close()}catch(e){console.error(e),o.shell.error(`Failed to delete ${t} library`)}})).showModal(!1)}}class qn{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){qn._instance||(qn._instance=new qn,qn._instance.closeDialogSubject$.subscribe((()=>{qn._instance.dialog=void 0}))),qn._instance.dialog||(qn._instance.dialog=await qn._instance.getDialog()),qn._instance.dialog.show()}async getDialog(){const t=dn.getInstance(),e=(await Un.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});fn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>t.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(e);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class zn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(t=!0){const e=dn.getInstance(),n=(await Un.getInstance()).widget,i=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),r=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,r])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);return this._view=a.View.fromRoot(l),this._view.name=zn.viewName,t&&o.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const t=Array.from(l.children).filter((t=>t.classList.contains("ui-box")));if(2!==t.length)return;const[e,n]=t,i=e.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;e.style.width=`${r}px`;const o=i-r;n.style.width=`${o}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((()=>{try{const t=zn._instance;t&&t._view&&"id"in o.shell.v&&o.shell.v.id===t._view.id&&t._duplicateManager?.refresh()}catch(t){console.error(t)}})))})),this._view}static async showView(t=!0){return zn._instance||(zn._instance=new zn),zn._instance._duplicateManager||(zn._instance._duplicateManager=await Dn.getInstance()),zn._instance.libManager||(zn._instance.libManager=await pn.getInstance()),t&&zn._instance._view&&Array.from(o.shell.views).find((t=>t.id&&t.id===zn._instance._view.id))?(o.shell.v=zn._instance._view,await zn._instance._duplicateManager.refresh(),zn._instance._view):(zn.closeExistingViews(),zn._instance.getView(t))}static closeExistingViews(){Array.from(o.shell.views).filter((t=>t.name===zn.viewName)).forEach((t=>t.close()))}async mergeSelectedLibs(){const t="Library with this name already exists",e=await pn.getInstance();if(await e.awaitLoaded(),await e.loadLibrariesPromise,!e.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n        Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=e.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const e=h(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!e&&e!==t),i.getButton("Save")?.classList?.toggle("d4-disabled",!!e)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let t=r.value;return t.endsWith(".json")||(t+=".json"),t}function h(e){return e&&e.trim()?e.endsWith(".json")&&l.includes(e)||l.includes(e+".json")?t:null:"Library name cannot be empty"}r.addValidator(h),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const t=c(),e=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(e,t,!1);const n=await(0,Nt.ub)();n.exclude=l,await(0,Nt.Eu)(n),await this.libManager.loadLibraries(!0),await Un.reloadWidget()}catch(e){o.shell.error(`Failed to save library ${t}. see console for details.`),console.error(e)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var Yn,Kn=function(t,e,n,i){return new(n||(n=Promise))((function(r,o){function s(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?r(t.value):(e=t.value,e instanceof n?e:new n((function(t){t(e)}))).then(s,a)}l((i=i.apply(t,e||[])).next())}))};class Zn{_setBreadcrumbsInViewName(){var t,e;const n=["Home","Demo",...(null!==(t=this._path)&&void 0!==t?t:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((t=>Kn(this,void 0,void 0,(function*(){const e=t[t.length-1];if(e===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===e?n:n.items.find((t=>t.text===e))})))),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const t=s.iconFA("home",(()=>{o.shell.v.close(),o.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));t.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(t)}const t=null===(e=o.shell.v.ribbonMenu.root.parentElement)||void 0===e?void 0:e.getElementsByClassName("d4-ribbon-name")[0];t&&(t.textContent="",t.appendChild(i.root))}}constructor(t,e,n=!1,i){var r,o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>Kn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>Kn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=t,this.description=e,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._path=null!==(o=null==i?void 0:i.path)&&void 0!==o?o:"",this._progress.max=0,this._progress.value=1,Zn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let n=s.iconFA("clock");this._isAutomatic||0===e&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=s.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var t;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(t=this._path)&&void 0!==t?t:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return Kn(this,void 0,void 0,(function*(){var t,e;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(t){console.error(t)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,te.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=s.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof a.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Kn(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,n){return Kn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");e.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),t.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(n),e}_changeStopState(){return Kn(this,void 0,void 0,(function*(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return Kn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Zn.currentObject=null}step(t,e,n){return this._steps[this.steps.length]={name:t,func:e,options:n},this}start(){return Kn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Zn.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Yn||(Yn={}));var Xn=n(966),Jn=n(608),Qn=n(1619);class ti{urlParams;funcName;options;df;view;constructor(t,e,n={}){this.urlParams=t,this.funcName=e,this.options=n}async init(t){this.df=t,await this.buildView()}async buildView(){const t=rt()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}?${t}`;const e={...this.options,sequenceColumnName:"sequence"};for(const[t,n]of this.urlParams.entries())switch(t){case re.n5.fixWidth:case re.n5.fitArea:e[t]=["1","on","true"].includes(n.toLowerCase());break;default:e[t]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ei{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const t=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:t,filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ni=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};class ii extends Vt{constructor(t,e){super(t,e)}render(t,e,n,i,r,o,s){t.save();try{if(!o.isTableCell)return;const s=o.cell?.column&&o.cell.column?.dart&&"true"===o.cell.column.getTag(Rt.Mn.applyToBackground);t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=o.cell.value;if(!a||a==wt._S)return;let l=Ot.S$,c="rgb(255, 255, 255)";if(this.monomerLib){const t=this.tableCol.getTag(wt.gp.alphabet),e=t===gt.YI.RNA||t===gt.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA;if(s){const t=this.monomerLib.getMonomerColors(e,a);l=t?.textcolor??l,c=t?.backgroundcolor??c}else l=this.monomerLib.getMonomerTextColor(e,a)}const h=Math.max(2,Math.floor(.15*i));s&&(t.fillStyle=c,t.fillRect(e,n,i,r)),t.fillStyle=l,t.fillText((0,gt.zS)(a,h),e+i/2,n+r/2,i)}finally{t.restore()}}onMouseMove(t,e){if(t.grid.dart!=this.gridCol?.grid.dart||t.gridColumn.dart!=this.gridCol?.dart||!t.tableColumn||!t.isTableCell)return!1;const n=t.tableColumn.getTag(wt.gp.alphabet),i=t.cell.value,r=t.grid.canvas.getBoundingClientRect(),o=t.bounds.right+r.left-4,a=t.bounds.bottom+r.top-4;if(i==wt._S)return s.tooltip.show(s.divText("gap"),o,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),o,a),!0;const l=n===gt.YI.RNA||n===gt.YI.DNA?ni.o.NUCLEOTIDE:ni.o.AA,c=this.monomerLib.getTooltip(l,i);return s.tooltip.show(c,o,a),!0}async awaitRendered(t=1e4,e=`${t} timeout`){return Promise.resolve()}static getOrCreate(t){const[e,n,i]=(0,Ft.BG)(t);let r=i.rendererBack;return r||(r=i.rendererBack=new ii(e,n)),r}}class ri extends a.GridCellRenderer{get name(){return jt.uF.MONOMER}get cellType(){return jt.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,n,i,r,o,s){ii.getOrCreate(o).render(t,e,n,i,r,o,s)}onMouseMove(t,e){ii.getOrCreate(t).onMouseMove(t,e)}}class oi{constructor(t,e,n=""){this.target=t,this.debugEnabled=e,this.prefix=n}error(t,e,n){return this.target.error(this.prefix+t,e,n)}warning(t,e){return this.target.warning(this.prefix+t,e)}info(t,e){return this.target.info(this.prefix+t,e)}debug(t,e){if(this.debugEnabled)return this.target.debug(this.prefix+t,e)}}class si extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const t=super.get("FontSize");return t&&!isNaN(t)?Number.parseInt(t):12}set fontSize(t){super.set("FontSize",t),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const t=super.get("MaxMonomerLength");return"long"===t?null:parseInt(t)}set maxMonomerLength(t){const e=null===t?"long":t.toString();super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t))}}class ai extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(t){this._properties=t}_initialized=!1;get initialized(){return this._initialized}constructor(t={debug:!1}){super(),super._logger=new oi(super.logger,t.debug)}completeInit(t,e,n,i){this._seqHelper=t,this._monomerLib=e,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(t){const[e,n]=(0,Ct.AP)(t);o.shell.error(e),this.logger.error(e,void 0,n)}}var li=n(2174);class ci extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(t,e){super(s.divV([])),this.seqCol=t,this.seqHelper=e}async init(){const t=this.seqHelper.getSeqHandler(this.seqCol),e=Di.properties.tooltipWebLogo,n=this.seqCol.getTag(ee.gp.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function hi(t,e,n,i){const r=Di.seqHelper.getSeqHandler(t);let o=null,s=null;for(let t=0;t<r.posList.length;++t)r.posList[t]==e&&(o=t),r.posList[t]==n&&(s=t);if(null===o&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${n??""})`;return r.getRegion(o,s,a)}const ui={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(gt.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class di{urlParams;funcName;view;data;constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??ui;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(gt.gp.positionNames,this.data.positionNames),this.data.regions&&e.setTag(gt.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class pi{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(t,e){this.call=t,this.seqHelper=e;const n=t=>this.call.inputParams[t].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:t=>t.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const t in this.call.inputParams)s.tooltip.bind(this.inputs[t].captionLabel,n(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&this.seqHelper.getSeqHandler(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?this.seqHelper.getSeqHandler(t):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),r=document.createElement("option");e.text=r.text=t,e.value=r.value=t,n.options.add(e),i.options.add(r)}n.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(gt.gp.regions):null,n=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const t of n){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const r=t.options[i],o=JSON.parse(r.value);o&&e===o.start&&n===o.end&&(t.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=e?`${n.name}(${e.name}): ${e.start}-${e.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(t).onOK((()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Di.handleErrorUI(t)}))})).show()}widget(){const t=s.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=s.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Di.handleErrorUI(t)}))}));return a.Widget.fromRoot(s.divV([t,s.div(e)]))}}var mi=n(8754);async function fi(t,e,n,i,r){const o=await async function(t,e,n,i,r){const o=(0,vt.R)(e,r),s=r.getSeqHandler(e).getNewColumnFromList("ref",[n]),l=r.getSeqHandler(s).getSplitted(0),c=i===ft.IDENTITY?function(t,e){const n=e.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=e.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<t.length?t.getOriginal(s):wt._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",e.rowCount),l=s.getRawData();for(let n=0;n<e.rowCount;++n){l[n]=0;for(let e=0;e<t.length;++e)(i[e]?i[e][n]:0)===o[e]&&++l[n];l[n]/=t.length}return s}(l,o):i===ft.SIMILARITY?await async function(t,e,n){const i=e.columns.toList();return await(0,bt.uL)(i,t,n)}(l,o,r):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=t.columns.getUnusedName(c.name),t.columns.add(c),c}(t,e,n,i,r);for(let t=0;t<o.length;t++)e.isNone(t)&&o.set(t,null,!1);return o}var gi=n(294),yi=n(330);const bi=OCL;var vi=n(9099);class wi{monomerSymbol;constructor(t){this.monomerSymbol=t}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const t=this.rGroups.getAtomicIdx(1);if(null===t)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:e,y:n}=this.atoms.atomCoordinates[t];this.atoms.shift({x:-e,y:-n})}alignR2AlongX(){const t=this.rGroups.getAtomicIdx(2);if(null===t)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const e=this.atoms.atomCoordinates[t],n=e.y/e.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(t){this.rGroups.deleteBondLineWithSpecifiedRGroup(t)}shiftCoordinates(t){this.atoms.shift(t)}rotateCoordinates(t){this.atoms.rotate(t)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(t){this.rGroups.removeRGroups(t)}replaceRGroupWithAttachmentAtom(t,e){this.rGroups.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.rGroups.getAttachmentAtomIdByRGroupId(t)}shiftBonds(t){this.bonds.shift(t)}capRGroups(t){this.rGroups.capRGroups(t)}}var Ci=n(6956);class Ai{atoms;bonds;constructor(t,e,n){this.atoms=e,this.bonds=n,this.rGroupIdToAtomicIndexMap=t.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(t){const e=this.rGroupIdToAtomicIndexMap.get(t);return void 0===e?null:e}removeRGroupsFromAtomBlock(t){t.forEach((t=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(t))throw new Error(`Cannot find atomic index for R group ${t}`)}));const e=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([e,n])=>t.includes(e))).map((([t,e])=>e));this.atoms.deleteAtoms(e)}removeRGroups(t){this.removeRGroupsFromAtomBlock(t),t.forEach((t=>{const e=this.replaceRGroupInBondsByDummy(t);this.rGroupBondPositionMap.set(t,e)}))}replaceRGroupInBondsByDummy(t){const e=this.rGroupIdToAtomicIndexMap.get(t);if(this.rGroupBondPositionMap.has(t))throw new Error(`R group ${t} is already handled`);const n=this.bonds.getPositionsInBonds(e+1);if(0===n.length)throw new Error(`Cannot find position for R group ${t}`);if(n.length>1)throw new Error(`More than one position for R group ${t}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(e+1),this.removeRGroupFromAtomicIdxMap(t,e),i}removeRGroupFromAtomicIdxMap(t,e){this.rGroupIdToAtomicIndexMap.delete(t);for(const[t,n]of this.rGroupIdToAtomicIndexMap)n>e&&this.rGroupIdToAtomicIndexMap.set(t,n-1)}deleteBondLineWithSpecifiedRGroup(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n}=e;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(t),this.rGroupIdToAtomicIndexMap.delete(t),this.rGroupBondPositionMap.forEach((t=>{t.bondLineIdx>n&&(t.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(t,e){const n=this.rGroupBondPositionMap.get(t);if(!n)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=e}getAttachmentAtomIdByRGroupId(t){const e=this.rGroupBondPositionMap.get(t);if(!e)throw new Error(`Cannot find position for R group ${t}`);const{bondLineIdx:n,nodeIdx:i}=e;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(t){this.rGroupIdToAtomicIndexMap.forEach(((e,n)=>{const i=t[n-1];i===Ci.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(e,i)}))}}class Si{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(t,e){this.rawAtomLines[t]=this.rawAtomLines[t].replace("R#",e)}deleteAtoms(t){this.coordinates=this.coordinates.filter(((e,n)=>!t.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((e,n)=>!t.includes(n)))}shift(t){this.coordinates=this.coordinates.map((e=>{const n=e.x+t.x,i=e.y+t.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${t.x}, ${t.y}`);return{x:n,y:i}}))}rotate(t){this.coordinates=this.coordinates.map((e=>{const n=e.x,i=e.y,r=n*Math.cos(t)-i*Math.sin(t),o=n*Math.sin(t)+i*Math.cos(t);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${t}`);return{x:r,y:o}}))}}class xi extends Si{constructor(t){super(),this.rawAtomLines=t.getAtomLines(),this.coordinates=this.rawAtomLines.map((t=>({x:parseFloat(t.substring(0,10)),y:parseFloat(t.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((t,e)=>{const n=this.coordinates[e];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${t.substring(20)}`}))}}class Ei{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(t){this.rawBondLines=this.rawBondLines.filter(((e,n)=>!t.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((e,n)=>!t.includes(n)))}getPositionsInBonds(t){const e=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===t&&e.push({bondLineIdx:i,nodeIdx:r})}))})),e}replacePositionsInBondsByDummy(t,e){void 0===e&&(e=-1),t.forEach((t=>{const{bondLineIdx:n,nodeIdx:i}=t;this.bondedAtomPairs[n][i]=e}))}removeAtomIdFromBonds(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e>t?e-1:e))))}shift(t){this.bondedAtomPairs=this.bondedAtomPairs.map((e=>e.map((e=>e+t))))}}class Mi extends Ei{constructor(t){super(),this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((t=>[parseInt(t.substring(0,3)),parseInt(t.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((t,e)=>{if(t.some((t=>-1===t)))throw new Error(`Bonded pair ${t} contains -1`);return`${t[0].toString().padStart(3," ")}${t[1].toString().padStart(3," ")}${this.rawBondLines[e].substring(6)}`}))}}class _i extends wi{constructor(t,e){super(e);const n=Re.getInstance(t);this.atoms=new xi(n),this.bonds=new Mi(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends Si{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawAtomLines=t.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const t=this.molfileHandler.x,e=this.molfileHandler.y;return Array.from(t).map(((t,n)=>({x:t,y:e[n]})))}get atomLines(){const t=/^(M  V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,e=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(t,((t,e,n,i,r,a)=>e+o+i+s+a)).replace(e,"")}))}replaceRGroupSymbolByElement(t,e){super.replaceRGroupSymbolByElement(t,e);const n=this.rawAtomLines[t].substring(3).split(" ");n.length>7&&(this.rawAtomLines[t]=`M  ${n.slice(0,7).join(" ")}`)}}class Ti extends Ei{molfileHandler;constructor(t){super(),this.molfileHandler=t,this.rawBondLines=t.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((t=>[t[0],t[1]]))}getBondLines(){const t=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((e,n)=>{if(e.some((t=>-1===t)))throw new Error(`Bonded pair ${e} contains -1`);return this.rawBondLines[n].replace(t,((t,n,i,r,o,s)=>`${n}${e[0]}${r}${e[1]}${s}`))}))}}class Li extends wi{constructor(t,e){super(e);const n=Re.getInstance(t);this.atoms=new Ii(n),this.bonds=new Ti(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni{static getInstance(t,e){if(Re.isMolfileV2K(t))return new _i(t,e);if(Re.isMolfileV3K(t))return new Li(t,e);throw new Error("Unsupported molfile version")}}class Pi{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(t,e,n,i,r,o){this.monomerSymbol=t,this.monomerIdx=e,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;Re.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,t,r)),this.molfileWrapper=Ni.getInstance(a,t),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[e]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(t,e,n){if(Pi.molfileV2KToV3KCache.has(t))return Pi.molfileV2KToV3KCache.get(t);let i=null;try{if(i=n.get_mol(t,JSON.stringify({mergeQueryHs:!0})),i){const e=i.get_v3Kmolblock();return Pi.molfileV2KToV3KCache.set(t,e),e}throw new Error(`Cannot convert ${e} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const t=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),e=this.monomerLib.getMonomer(t,this.monomerSymbol);if(!e)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return e}getCapGroupElements(t){return t.rgroups.map((t=>(t.capGroupSmiles||t.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(t){this.molfileWrapper.shiftCoordinates(t)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(t){this.molfileWrapper.removeRGroups(t)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(t,e){this.molfileWrapper.replaceRGroupWithAttachmentAtom(t,e)}getAttachmentAtomByRGroupId(t){return this.molfileWrapper.getAttachmentAtomByRGroupId(t)}deleteBondLineWithSpecifiedRGroup(t){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(t)}shiftBonds(t){this.molfileWrapper.shiftBonds(t)}}class $i{rdKitModule;monomerLib;constructor(t,e,n){this.rdKitModule=e,this.monomerLib=n,this.helm=new vi.f(t)}monomerWrappers=[];helm;addMonomer(t,e,n){if(t===wt.b9[gt.Hi.HELM])return;const i=this.monomerWrappers.length,r=new Pi(t,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(r)}getAtomNumberShifts(){const t=[];let e=0;return this.monomerWrappers.forEach((n=>{t.push(e),e+=n.getAtomLines().length})),t}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((t=>{const e=t.map((t=>t.monomerIdx)),n=t.map((t=>t.rGroupId)),i=e.map((t=>this.monomerWrappers[t])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const t=[],e=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((t,e)=>{t.shiftBonds(n[e])})),this.restoreBondsBetweenMonomers();const i=new gi.Cg;for(const[n,r]of rt().enumerate(this.monomerWrappers)){const o=t.length,s=e.length;t.push(...n.getAtomLines()),e.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(r)?Ht.o.NUCLEOTIDE:Ht.o.AA;i.set(r,{biotype:a,symbol:n.monomerSymbol,atoms:rt().count(o).take(n.atomCount).toArray(),bonds:rt().count(s).take(n.bondCount).toArray()})}const r=t.length,o=e.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(t),this.getV3KBondBlock(e),"M  V30 END CTAB\nM  END"].join("\n"),monomers:i}}getV3KHeader(t,e){return`\n     Datagrok\n\n  0  0  0  0  0  0  0  0  0  0999 V3000\nM  V30 BEGIN CTAB\nM  V30 COUNTS ${t} ${e} 0 0 1`}getV3KAtomBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN ATOM",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,r)=>e+i+r))})),"M  V30 END ATOM"].join("\n")}getV3KBondBlock(t){const e=/^(M  V30 )(\d+)( .*)$/;return["M  V30 BEGIN BOND",...t.map(((t,n)=>{const i=n+1;return t.replace(e,((t,e,n,r)=>e+i+r))})),"M  V30 END BOND"].join("\n")}}class Ri{constructor(t){this.molfileHandler=Re.getInstance(t)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(t){return{x:this.molfileHandler.x[t],y:this.molfileHandler.y[t]}}}class Oi{helmHelper;rdKitModule;monomerLib;constructor(t,e,n){this.helmHelper=t,this.rdKitModule=e,this.monomerLib=n}convertToSmiles(t){const e=t.dataFrame,n=this.getSmilesList(t),i=`smiles(${t.name})`,r=e?e.columns.getUnusedName(i):i;return a.Column.fromStrings(r,n.map((t=>null===t?"":t)))}getSmilesList(t){return this.convertToMolfileV3KColumn(t).toList().map((t=>a.chem.convert(t,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(t){try{if(!t)return"";return bi.Molecule.fromMolfile(t).toMolfileV3().replace("STERAC1","STEABS")}catch(t){const[e,n]=(0,Ct.AP)(t);return Di.logger.error(e,void 0,n),""}}getMolV3000ViaOCL(t,e){const n=t.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let t=0;t<n.length;t++){i[t]=this.molV3KtoMolV3KOCL(n[t]);const e=t/n.length*100;r.update(e,`${e?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(e,i)}convertToRdKitBeautifiedMolfileColumn(t,e,n,i){const r=t.dataFrame,o=this.convertToMolfileV3KColumn(t).toList().map((t=>{if(""===t)return null;const e=n.get_mol(t);return e?(e.set_new_coords(),e.normalize_depiction(1),e.straighten_depiction(!0),e):null})),s=`molfile(${t.name})`,l=r?r.columns.getUnusedName(s):s;return e?this.getMolV3000ViaOCL(o,l):a.Column.fromStrings(l,o.map((t=>{if(null===t)return"";const e=t.get_v3Kmolblock();return t.delete(),e})))}convertToMolfileV3KColumn(t){const e=t.dataFrame,n=this.convertToMolfileV3K(t.toList()).map((t=>t.molfile)),i=(0,yi.kA)(e,`molfileV3K(${t.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(t){const e=new Array(t.length);for(let n=0;n<t.length;++n){const i=t[n];if(!i){e[n]=gi.vF.createEmpty();continue}let r;try{r=this.getPolymerMolfile(i)}catch(t){const[e,n]=(0,Ct.AP)(t);Di.logger.error(e,void 0,n),r=gi.vF.createEmpty()}e[n]=r}return e}getPolymerGraphColumn(t){const e=t.toList(),n=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",n)}getPolymerMolfile(t){const e=this.helmHelper.removeGaps(t),n=e.resHelm,i=new Map;for(const[t,n]of e.monomerMap?.entries()??[])i.set(n,t);const r=this.helmHelper.getMolfiles([n])[0],o=new Ri(r),s=new $i(n,this.rdKitModule,this.monomerLib);o.monomerSymbols.forEach(((t,e)=>{const n=o.getMonomerShifts(e);s.addMonomer(t,e,n)}));const a=s.compileToMolfile(),l=new gi.Cg;for(const[t,e]of a.monomers.entries()){const n=i.get(t);l.set(n,e)}return new gi.vF(a.molfile,l)}}class ki{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(t,e){if(this.seqHelper=e,t.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${a.TYPE.STRING}'.`);this._column=t;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ut.notationProvider]??null);const i=this.isFasta()?wt.b9[gt.Hi.FASTA]:this.isSeparator()?wt.b9[gt.Hi.SEPARATOR]:this.isHelm()?wt.b9[gt.Hi.HELM]:this.isCustom()?this.notationProvider?.defaultGapOriginal??wt.b9[gt.Hi.SEPARATOR]:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(gt.gp.aligned)||!this.column.tags.has(gt.gp.alphabet)||!this.column.tags.has(gt.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===gt.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag(gt.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,e)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(gt.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(gt.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${gt.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version,!this.isSeparator()||this.isCustom()&&this.notationProvider||t.temp.seqHandlerRefined||(this.refineSeparatorNotation(),t.temp.seqHandlerRefined=!0)}async refineSeparatorNotation(){const t=((t,e,n)=>{const i={};let r=!0,o=null;for(const e of t){const t=e?n(e):[];if(null===o?o=t.length:t.length!==o&&(r=!1),t.length>=3)for(const e of t)e in i||(i[e]=0),i[e]+=1}return{freq:i,sameLength:r}})([...new Set((this.column.length<100?rt().count(0).take(Math.min(100,this.column.length)).map((t=>this.column.get(t))):this.column.categories.slice(0,100)).map((t=>t?t.substring(0,500):"")).filter((t=>0!==t.length)))],0,(t=>t.split(this.separator)));let e=!1;const n=[{package:"SequenceTranslator",name:"refineNotationProviderForHarmonizedSequence"}];for(const i of n)try{const n=a.Func.find(i);if(0===n.length)continue;const r=n[0].prepare({col:this.column,stats:t,separator:this.separator}),o=(await r.call()).getOutputParamValue();e||=o}catch(t){console.error(t)}e&&(delete this.column.temp[Ut.seqHandler],this.column.fireValuesChanged())}static setTags(t){const e=t.column.meta.units;if([gt.Hi.FASTA,gt.Hi.SEPARATOR].includes(e)){if(!t.column.getTag(gt.gp.alphabet)&&0===Object.keys(t.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let e=t.column.getTag(gt.gp.aligned);null===e&&(e=t.stats.sameLength?"SEQ.MSA":"SEQ",t.column.setTag(gt.gp.aligned,e));let n=t.column.getTag(gt.gp.alphabet);if(null===n&&(n=(0,kt.pc)(t.stats.freq,gt.q7),t.column.setTag(gt.gp.alphabet,n)),n===gt.YI.UN){const e=Object.keys(t.stats.freq).length,n=Object.keys(t.stats.freq).some((t=>t.length>1));t.column.setTag(gt.gp.alphabetSize,e.toString()),t.column.setTag(gt.gp.alphabetIsMultichar,n?"true":"false")}}else if(e===gt.Hi.HELM){let e=t.column.getTag(gt.gp.alphabet);null===e&&(e=(0,kt.p0)(t.stats.freq,gt.q7,t.defaultGapOriginal),t.column.setTag(gt.gp.alphabet,e))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const t=this.column.getTag(gt.gp.separator)??void 0;if(this.notation===gt.Hi.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory  for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag(gt.gp.aligned);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag(gt.gp.alphabet);if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get defaultBiotype(){return this.alphabet===gt.YI.RNA||this.alphabet===gt.YI.DNA?Ht.o.NUCLEOTIDE:Ht.o.AA}get helmCompatible(){return this.column.getTag(gt.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==gt.Hi.HELM||this.alphabet==gt.YI.UN){const t=this.column.getTag(gt.gp.alphabetSize);let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case gt.YI.PT:return 20;case gt.YI.DNA:case gt.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===gt.Hi.HELM||this.alphabet===gt.YI.UN&&"true"===this.column.getTag(gt.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(t,e){if(this.cached&&void 0===e){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let e=this._splitted[t]?this._splitted[t].deref():void 0;if(!e){const n=this.column.get(t);e=this.splitter(n),this._splitted[t]=new WeakRef(e)}return e}{const n=this.column.get(t);return this.getSplitter(e)(n)}}getValue(t,e){return this.column.get(t),new Wt(t,this)}getHelm(t){let e;const n=this.column.get(t);return e=this.notation===gt.Hi.HELM?n:this.notation===gt.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(gt.Hi.HELM)(n),e}_stats=null;get stats(){if(null===this._stats){const t={};let e=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(e=!1);for(let e=0;e<i.length;++e){const n=i.getCanonical(e);n in t||(t[n]=0),t[n]+=1}}this._stats={freq:t,sameLength:e}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...rt().count(0).take(this.column.length).map((t=>this.getSplitted(t).length)))),this._maxLength}_posList=null;get posList(){if(null===this._posList){const t=this.column.getTag(gt.gp.positionNames);this._posList=t?t.split(gt.z1).map((t=>t.trim())):rt().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===gt.Hi.FASTA}isSeparator(){return this.notation===gt.Hi.SEPARATOR||!!this.separator}isHelm(){return this.notation===gt.Hi.HELM}isCustom(){return this.notation===gt.Hi.CUSTOM}isRna(){return this.alphabet===gt.YI.RNA}isDna(){return this.alphabet===gt.YI.DNA}isPeptide(){return this.alphabet===gt.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||t===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return gt.Hi.FASTA;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return gt.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.Hi.HELM;if(this.units.toLowerCase().startsWith(gt.Hi.CUSTOM))return gt.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e,n,i){const r=this.column,o=t.toLowerCase()+"("+r.name+")",s=n??r.dataFrame?.columns.getUnusedName(o)??o,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=t,t===gt.Hi.SEPARATOR){if(!e)throw new Error(`Notation '${gt.Hi.SEPARATOR}' requires separator value.`);l.setTag(gt.gp.separator,e)}l.setTag(a.TAGS.CELL_RENDERER,t===gt.Hi.HELM?"helm":"sequence");const c=r.getTag(gt.gp.aligned);c&&l.setTag(gt.gp.aligned,c);let h=r.getTag(gt.gp.alphabet);h||this.notation!==gt.Hi.HELM||t===gt.Hi.HELM||(h=gt.YI.UN),null!=h&&l.setTag(gt.gp.alphabet,h);let u=r.getTag(gt.gp.alphabetSize);null!=h&&u&&l.setTag(gt.gp.alphabetSize,u);const d=r.getTag(gt.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(gt.gp.alphabetIsMultichar,d),t==gt.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(gt.gp.alphabetSize,u)),l}getNewColumnFromList(t,e){return this.getNewColumn(this.notation,this.separator,t,e)}static unitsStringIsValid(t){return t=t.toLowerCase(),[gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,n){if(!ki.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",e,new Array(t).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(t){let e=null;if(e=this.notationProvider?this.notationProvider.splitter:null,e)return e;if(this.units.toLowerCase().startsWith(gt.Hi.FASTA))return null===this.column.getTag(gt.gp.alphabet)||this.getAlphabetIsMultichar()?gt.J9:kt.tm;if(this.units.toLowerCase().startsWith(gt.Hi.SEPARATOR))return(0,gt.dh)(this.separator,t);if(this.units.toLowerCase().startsWith(gt.Hi.HELM))return gt.qp;throw new Error(`Unexpected units ${this.units} .`)}split(t){return this.splitter(t)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ue.Z.HAMMING;switch(this.alphabet){case gt.YI.DNA:case gt.YI.RNA:case gt.YI.PT:}return ue.Z.LEVENSHTEIN}getDistanceFunction(){return ue.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(gt.gp.isHelmCompatible))return"true"===this.column.getTag(gt.gp.isHelmCompatible);const t=(await(0,bt.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),e=new Set(t),n=((0,gt.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let t=0;t<i;++t){const i=r[t];if(!(i in n)){n.add(i);const r=this.getSplitted(t);for(let t=0;t<r.length;++t){const n=r.getCanonical(t);if(!e.has(n))return this.column.setTag(gt.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(gt.gp.isHelmCompatible,"true"),!0}toFasta(t){return t===gt.Hi.FASTA}toSeparator(t){return t===gt.Hi.SEPARATOR}toHelm(t){return t===gt.Hi.HELM}convertHelmToFastaSeparator(t,e,n,i){i||(i=this.toFasta(e)?wt.b9[gt.Hi.FASTA]:wt.b9[gt.Hi.SEPARATOR]),n||(n=this.toFasta(e)?"":this.separator);const r=t.startsWith("RNA"),o=(0,gt.qp)(t),s=[];for(let t=0;t<o.length;++t){let n=o.getOriginal(t);if(r&&(n=n.replace(bn.EK,"$1")),n===wt.b9[gt.Hi.HELM])s.push(i);else if(this.toFasta(e)&&n.length>1){const t="["+n+"]";s.push(t)}else s.push(n)}return s.join(n)}convert(t,e){const n=this.getJoiner({notation:t,separator:e}),i=this.getNewColumn(t,e);return i.init((t=>{const e=this.getSplitted(t);return n(e)})),i}getRegion(t,e,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=t??0,o=e??this.maxLength-1,s=this.getJoiner(),a=o-r+1,l=wt.b9[this.notation];i.init((t=>{const e=this.getSplitted(t),n=new Array(a);for(let t=0;t<a;++t){const i=r+t;n[t]=i<e.length?e.getOriginal(i):l}return s(new kt.Mu(n,l))}));const c=t=>{const e=t.split(",").map((t=>t.trim())),n=new Array(a);for(let t=0;t<a;++t){const i=r+t;n[t]=i<e.length?e[i]:"?"}return n.join(gt.z1)},h=this.column.getTag(gt.gp.positionNames);h&&i.setTag(gt.gp.positionNames,c(h));const u=this.column.getTag(gt.gp.positionLabels);return u&&i.setTag(gt.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(t){const e=t?t.notation:this.notation,n=t?t.separator:this.separator;let i;const r=this;switch(e){case gt.Hi.FASTA:i=function(t){return r.joinToFasta(t,r.isHelm())};break;case gt.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${e}'.`);i=function(t){return Gi(t,n,r.isHelm())};break;case gt.Hi.HELM:{const t=r.alphabet===gt.YI.DNA||r.alphabet===gt.YI.RNA,e=r.getHelmWrappers();i=function(n){return Fi(n,e,t)};break}default:throw new Error(`Unexpected notation '${e}'.`)}return i}getConverter(t,e=void 0){if(t===gt.Hi.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${gt.Hi.SEPARATOR}'.`);const n=this;if(t===gt.Hi.FASTA)return function(t){return n.convertToFasta(t)};if(t===gt.Hi.HELM)return function(t){return n.convertToHelm(t)};if(t===gt.Hi.SEPARATOR)return function(t){return n.convertToSeparator(t,e)};throw new Error}static forColumn(t,e){let n=t.temp[Ut.seqHandler];return n&&n.columnVersion===t.version||(n=t.temp[Ut.seqHandler]=new ki(t,e)),n}joinToFasta(t,e){const n=new Array(t.length);for(let i=0;i<t.length;++i){const r=t.getOriginal(i);let o=t.getOriginal(i);e&&(o=o.replace(bn.EK,"$1")),r===wt._S?o=wt.b9[gt.Hi.FASTA]:r===bn.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(t){const e=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(t):e(t);return this.joinToFasta(n,this.isHelm())}convertToSeparator(t,e){return Gi(this.isHelm()?this.splitterAsHelmNucl(t):this.splitter(t),e,this.isHelm())}convertToHelm(t){if(this.notation==gt.Hi.HELM)return t;const e=this.getHelmWrappers(),n=t.startsWith("DNA")||t.startsWith("RNA");return Fi(this.splitter(t),e,n)}splitterAsHelmNucl(t){const e=this.splitter(t),n=new Array(e.length),i=t.startsWith("DNA"),r=t.startsWith("RNA");for(let t=0;t<e.length;++t){let o=e.getOriginal(t);(i||r)&&(o=o.replace(bn.EK,"$1"),o=o===bn.q7?null:o),n[t]=o||null}return new kt.Mu(n.filter((t=>!!t)),wt.b9[gt.Hi.HELM])}getRendererBack(t,e){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(t,e)),i}}function Gi(t,e,n){const i=new Array(t.length);for(let e=0;e<t.length;++e){const r=t.getCanonical(e);let o=t.getOriginal(e);n&&(o=o.replace(bn.EK,"$1")),r===wt._S?o=wt.b9[gt.Hi.SEPARATOR]:r===bn.q7&&(o=""),i[e]=o}return i.join(e)}function Fi(t,e,n){const[i,r,o,s]=e,a=new Array(t.length);for(let e=0;e<t.length;++e){const i=t.getCanonical(e);let s=t.getOriginal(e);i===wt._S?s=wt.b9[gt.Hi.HELM]:(n&&(s=s.replace(bn.EK,"$1")),s=1===s.length?`${r}${s}${o}`:`${r}[${s}]${o}`),a[e]=s}return`${i}${a.join(".")}${s}`}class Hi{libHelper;rdKitModule;constructor(t,e){this.libHelper=t,this.rdKitModule=e}getSeqHandler(t){return ki.forColumn(t,this)}getSeqMonomers(t){const e=this.getSeqHandler(t);return Object.keys(e.stats.freq)}async getHelmToMolfileConverter(t){const e=await(0,ke.b2)();return new Oi(e,this.rdKitModule,t)}helmToAtomicLevelSingle(t,e,n,i=!0){if(!t)return gi.vF.createEmpty();const r=e.convertToMolfileV3K([t])[0];if(!r||!r.molfile)return gi.vF.createEmpty();let o=null;try{let t=r.molfile;if(i){if(o=this.rdKitModule.get_mol(t),!o)return gi.vF.createEmpty();o.set_new_coords(),o.normalize_depiction(1),o.straighten_depiction(!0),t=o.get_v3Kmolblock()}return n&&(t=e.molV3KtoMolV3KOCL(t)),new gi.vF(t,r.monomers)}catch(t){const[e,n]=(0,Ct.AP)(t);return Di.logger.error(e,void 0,n),gi.vF.createEmpty()}finally{o?.delete()}}async helmToAtomicLevel(t,e,n,i){const r=i??this.libHelper.getMonomerLib(),s=t.dataFrame,l=(0,yi.qj)(s,t.name),c=await this.getHelmToMolfileConverter(r),h=t.toList(),u=new Array(t.length),d=a.Func.find({package:"Chem",name:"beautifyMols"})[0],p=a.Func.find({package:"Chem",name:"convertToV3KViaOCL"})[0];for(let n=0;n<t.length;n++)u[n]=this.helmToAtomicLevelSingle(h[n],c,e&&!p,!d).molfile;if(d){const e=await d.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n])}if(e&&p){const e=await p.apply({mols:u});if(e&&Array.isArray(e)&&e.length===t.length)for(let n=0;n<t.length;n++)e[n]&&(u[n]=e[n]);else o.shell.warning("OCL function returned an unexpected result")}const m=a.Column.fromStrings(l,u);return m.semType=a.SEMTYPE.MOLECULE,m.meta.units=a.UNITS.Molecule.MOLBLOCK,m.setTag(".sequence-src-col",t.name),{molCol:m,warnings:[]}}setUnitsToFastaColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.FASTA)throw new Error(`The column of notation '${gt.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);t.column.meta.units=gt.Hi.FASTA,ki.setTags(t)}setUnitsToSeparatorColumn(t,e){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE||t.column.meta.units!==gt.Hi.SEPARATOR)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${gt.Hi.SEPARATOR}' must have the separator tag.`);t.column.meta.units=gt.Hi.SEPARATOR,t.column.setTag(gt.gp.separator,e),ki.setTags(t)}setUnitsToHelmColumn(t){if(t.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${gt.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);t.column.meta.units=gt.Hi.HELM,ki.setTags(t)}}class Bi{constructor(t){this.canvas=null,this.ctx=null,this.config={x:t.x||0,y:t.y||0,width:t.width||0,height:t.height||0,windowStartPosition:t.windowStartPosition||1,positionWidth:t.positionWidth||15,totalPositions:t.totalPositions||5e3,headerHeight:t.headerHeight||50,sliderHeight:t.sliderHeight||8,currentPosition:t.currentPosition||1,cellBackground:void 0===t.cellBackground||t.cellBackground,sliderColor:t.sliderColor||"rgba(220, 220, 220, 0.4)",onPositionChange:t.onPositionChange||((t,e)=>{}),...t},this.eventElement=s.div(),this.eventElement.style.position="absolute",this.config.canvas.parentElement?.appendChild(this.eventElement),this.state={isDragging:!1,dragStartX:0},this.init()}init(){if(this.canvas=this.config.canvas,!this.canvas)return void console.error("canvas not found.");const t=this.canvas.getContext("2d");t?(this.ctx=t,this.eventElement.addEventListener("mousedown",this.handleMouseDown.bind(this)),this.eventElement.addEventListener("mousemove",this.handleMouseMove.bind(this)),this.eventElement.addEventListener("mouseup",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("mouseleave",this.handleMouseUp.bind(this)),this.eventElement.addEventListener("click",this.handleClick.bind(this)),this.eventElement.addEventListener("wheel",this.handleMouseWheel.bind(this)),window.addEventListener("keydown",this.handleKeyDown.bind(this))):console.error("Failed to get 2D context from canvas")}get isValid(){return!!this.canvas&&!!this.ctx&&this.config.height>=this.config.headerHeight}draw(t,e,n,i,r,o,s){if(this.config.x==t&&this.config.y==e&&this.config.width==n&&this.config.height==i&&this.config.currentPosition==r&&this.config.windowStartPosition==o||Object.assign(this.config,{x:t,y:e,width:n,height:i,currentPosition:r,windowStartPosition:o}),!this.isValid)return void(this.eventElement.style.display="none");this.ctx.save(),this.ctx.clearRect(t,e,n,i),this.ctx.translate(t,e),this.ctx.rect(0,0,n,i),this.ctx.clip();const a=n,l=i,c=this.config.headerHeight-this.config.sliderHeight;this.ctx.fillStyle=this.config.sliderColor,this.ctx.fillRect(0,c,a,this.config.sliderHeight);const h=Math.floor(this.config.width/this.config.positionWidth),u=Math.max(1,this.config.windowStartPosition),d=this.config.totalPositions-h,p=d<=0?0:u/d*(a-this.sliderWidth),m=d<=0?a:this.sliderWidth;if(this.ctx.fillStyle="rgba(150, 150, 150, 0.5)",this.ctx.fillRect(p,c,m,this.config.sliderHeight),this.config.currentPosition>=1&&this.config.currentPosition<=this.config.totalPositions){const t=(this.config.currentPosition-1)/(this.config.totalPositions-1),e=Math.round(t*a);this.ctx.fillStyle="#3CB173",this.ctx.fillRect(e-1,c-2,3,this.config.sliderHeight+4)}for(let t=0;t<h;t++){const e=u+t;if(e>this.config.totalPositions)break;const n=t*this.config.positionWidth,i=this.config.positionWidth,r=n+i/2;this.config.cellBackground&&(this.ctx.fillStyle=t%2==0?"rgba(248, 248, 248, 0.3)":"rgba(242, 242, 242, 0.2)",this.ctx.fillRect(n,5,i,Math.min(this.config.headerHeight-5,l-5)-this.config.sliderHeight),this.ctx.strokeStyle="rgba(220, 220, 220, 0.7)",this.ctx.beginPath(),this.ctx.moveTo(n,5),this.ctx.lineTo(n,Math.min(this.config.headerHeight,l)-this.config.sliderHeight),this.ctx.stroke()),this.ctx.fillStyle="#999999",this.ctx.beginPath(),this.ctx.arc(r,10,1,0,2*Math.PI),this.ctx.fill(),(e===this.config.currentPosition||(1===e||e%10==0)&&Math.abs(e-this.config.currentPosition)>1)&&(this.ctx.fillStyle="#333333",this.ctx.font="12px monospace",this.ctx.textAlign="center",this.ctx.textBaseline="middle",this.ctx.fillText(e.toString(),r,20)),e===this.config.currentPosition&&(this.ctx.fillStyle="rgba(60, 177, 115, 0.2)",this.ctx.fillRect(n,0,i,c))}this.ctx.restore(),s.preventDefault(),this.eventElement.style.display="block",this.eventElement.style.left=`${this.config.x}px`,this.eventElement.style.top=`${this.config.y}px`,this.eventElement.style.width=`${this.config.width}px`,this.eventElement.style.height=`${this.config.height}px`}getCoords(t){const e=this.canvas.getBoundingClientRect();return{x:t.clientX-e.left-this.config.x,y:t.clientY-e.top-this.config.y}}isInHeaderArea(t){const{x:e,y:n}=this.getCoords(t);return e>=0&&e<=this.config.width&&n>=0&&n<=this.config.headerHeight}get positionWidth(){return this.config.positionWidth}set positionWidth(t){this.config.positionWidth=t}isInSliderArea(t){const{y:e}=this.getCoords(t),n=this.config.headerHeight-this.config.sliderHeight;return e>n&&e<n+this.config.sliderHeight}get sliderWidth(){const t=this.config.width/this.config.totalPositions*(this.config.width/this.config.positionWidth);return Math.max(t,20)}isInSliderDraggableArea(t){const{x:e,y:n}=this.getCoords(t),i=this.config.headerHeight-this.config.sliderHeight,r=Math.floor(this.config.width/this.config.positionWidth),o=Math.max(1,this.config.windowStartPosition),s=this.config.totalPositions-r,a=s<=0?0:o/s*(this.config.width-this.sliderWidth);return n>i&&n<i+this.config.sliderHeight&&e>=a&&e<a+this.sliderWidth}handleMouseDown(t){if(!this.isValid)return;const{x:e}=this.getCoords(t);this.isInSliderDraggableArea(t)&&(this.state.isDragging=!0,this.state.dragStartX=e,this.handleSliderDrag(e),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation())}handleMouseWheel(t){if(this.isValid&&this.isInHeaderArea(t)){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e=t.shiftKey?Math.sign(t.deltaY):Math.sign(t.deltaX||t.deltaY),n=t.shiftKey?3:1,i=this.config.windowStartPosition+e*n,r=Math.floor(this.config.width/this.config.positionWidth),o=this.config.totalPositions-r+1;this.config.windowStartPosition=Math.max(1,Math.min(o,i)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseMove(t){if(!this.state.isDragging||!this.isValid)return;const e=this.canvas.getBoundingClientRect(),n=t.clientX-e.left-this.config.x;this.handleSliderDrag(n),t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}handleKeyDown(t){if(this.isValid&&!(this.config.currentPosition<1)){if("ArrowLeft"===t.key||"ArrowRight"===t.key){t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation();const e="ArrowLeft"===t.key?-1:1,n=Math.min(Math.max(this.config.currentPosition+e,1),this.config.totalPositions);if(n===this.config.currentPosition)return;this.config.currentPosition=n;const i=Math.floor(this.config.width/this.config.positionWidth),r=this.config.windowStartPosition;(n<r||n>r+i-1)&&(this.config.windowStartPosition=e<0?n:Math.max(1,n-i+1))}else{if("Escape"!==t.key)return;this.config.currentPosition=-2,t.preventDefault(),t.stopPropagation(),t.stopImmediatePropagation()}"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}handleMouseUp(){this.state.isDragging=!1}handleSliderDrag(t){if(!this.isValid)return;const e=this.sliderWidth,n=this.config.width-e,i=Math.max(0,Math.min(this.config.width,t)),r=Math.floor(this.config.width/this.config.positionWidth),o=Math.floor(this.config.width/this.config.positionWidth),s=this.config.totalPositions-o,a=Math.max(0,i-e/2)/n*s;this.config.windowStartPosition=Math.max(1,Math.min(a,this.config.totalPositions-r+1)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}get headerHeight(){return this.config.headerHeight}set headerHeight(t){this.config.headerHeight=t}handleClick(t){if(!this.isValid)return;const{x:e,y:n}=this.getCoords(t);if(n<this.config.headerHeight-this.config.sliderHeight&&n>=0){const t=this.config.positionWidth,n=Math.round(e/t-.5),i=this.config.windowStartPosition+n;i>=1&&i<=this.config.totalPositions&&(this.config.currentPosition=i,"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange()))}}getWindowRange(){return{start:this.config.windowStartPosition,end:Math.min(this.config.totalPositions,this.config.windowStartPosition+Math.floor(this.config.width/this.config.positionWidth))}}updateConfig(t){Object.assign(this.config,t),this.config.currentPosition=Math.min(this.config.currentPosition,this.config.totalPositions),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}getCurrentPosition(){return this.config.currentPosition}setCurrentPosition(t){this.config.currentPosition=Math.max(1,Math.min(this.config.totalPositions,t)),"function"==typeof this.config.onPositionChange&&this.config.onPositionChange(this.config.currentPosition,this.getWindowRange())}}const Di=new ai;async function Vi(){return await pn.getInstance()}class ji{_palette;constructor(t){this._palette=t}get(t){return this._palette[t]}}let Ui=null;async function Wi(){null===Ui&&(Ui=async function(){const t="Bio: _package.initBio()";Di.logger.debug(`${t}, start`);const e=window.performance.now(),n=await(0,Pt.j)(),i=await Di.getProperties(),r=new si(i);Di.properties=r;const s=await pn.getInstance(),l=await(0,Nt.ub)();l.explicit&&(l.explicit=[],await(0,Nt.Eu)(l)),await s.awaitLoaded(1/0),s.initialLoadCompleted||await s.loadMonomerLib(),s.loadMonomerSets();const c=s.getMonomerLib(),h=s.getMonomerSets(),u=window.performance.now();Di.logger.debug(`${t}, loading ET: ${u-e} ms`);const d=new Hi(s,n);Di.completeInit(d,c,h,n),Di.logger.debug(`${t}, end`),function(){const t=t=>{setTimeout((()=>{if(t.isDetached)return;const e=t.dataFrame;if(!e)return;const n=e.columns.bySemTypeAll(a.SEMTYPE.MACROMOLECULE);for(const e of n){const n=Di.seqHelper.getSeqHandler(e);if(!n)continue;if(n.isHelm()||n.alphabet===gt.YI.UN)continue;const i=t.col(e.name);if(!i)continue;let r=!!t.tableView&&Array.from(t.tableView.viewers).some((t=>"Sequence Position Statistics"===t.type));const o=n.isMsa(),s=(t,e)=>Number.isNaN(t)?e:t,l=()=>s(Math.max(Number.parseInt(e.getTag(gt.gp.positionShift)??"0"),0),0)+1,c=()=>s(Number.parseInt(e.getTag(gt.gp.selectedPosition)??"-2"),-2),h=()=>Ot.Jy.getFontSettings(e).fontWidth;let u=0,d=0;const p=e.categories;for(let t=0;t<p.length;t++){const e=p[t];e&&e.length>d&&(d=e.length,u=t)}const m=p[u],f=n.splitter(m),g=f?f.length:30;if(g<50)continue;const y=40,b=new Bi({canvas:t.overlay,headerHeight:y,totalPositions:g+1,onPositionChange:(n,i)=>{setTimeout((()=>{const o=l(),s=c();if(o!==i.start&&e.setTag(gt.gp.positionShift,(i.start-1).toString()),n>=0&&s!==n&&(e.setTag(gt.gp.selectedPosition,n.toString()),!r&&t.tableView)){r=!0;const n=t.tableView.addViewer("Sequence Position Statistics",{sequenceColumnName:e.name});t.tableView.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Sequence Position Statistics",.4)}}))}});t.props.colHeaderHeight=65,setTimeout((()=>{t.isDetached||(i.width=400)}),300),t.sub(t.onCellRender.subscribe((n=>{const r=n.cell;if(!r||!r.isColHeader||r?.gridColumn?.name!==i?.name)return;const s=n.bounds;if(!s||s.height<=50)return;const a=s.height-y;if(a>20){b.headerHeight=s.height-20;const n=t.overlay.getContext("2d");if(!n)return;n.save(),n.rect(s.x,s.y,s.width,20),n.clip(),n.font=t.props.colHeaderFont??"bold 13px Roboto, Roboto Local",n.fillStyle="#4a4a49",n.textAlign="center",n.textBaseline="middle";const i=s.x+s.width/2,r=s.y+10;n.fillText(e.name??"",i,r),n.restore()}else b.headerHeight=Math.max(y,s.height);const u=Math.max(0,a??0)>20?20:0,d=h();b.positionWidth=d+(o?8:0);const p=l(),m=o?0:4;b.draw(s.x+m,s.y+u,s.width-m,s.height-u,c(),p,n)})))}}),1e3)},e=(o.events.onViewerAdded.subscribe((e=>{if(!(e.args&&e.args.viewer instanceof a.Grid))return;const n=e.args.viewer;t(n)})),o.shell.tableViews);for(const n of e){const e=n?.grid;e&&t(e)}}()}()),await Ui}function qi(t){const e=new ci(t,Di.seqHelper);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();o.shell.error(e)})),e}function zi(){return Di.monomerLib}function Yi(t){return Di.seqHelper.getSeqHandler(t)}function Ki(t){const e="getRegionTopMenu",n=a.Func.find({package:Di.name,name:e});if(1!==n.length)throw new Error(`Package '${Di.name}' func '${e}' not found`);const i=n[0].prepare({table:t.dataFrame,sequence:t});return new pi(i,Di.seqHelper).widget()}async function Zi(t){return async function(){const t=s.label("Manage monomer libraries");return fn()(t).addClass("d4-link-action"),t.onclick=async()=>await Vn(),new a.Widget(t)}()}function Xi(t){try{new pi(t,Di.seqHelper).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;o.shell.error(`Get region editor error: ${e}`),Di.logger.error(e,void 0,n)}}function Ji(t){const e=new ei;s.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Qi(t){const e=new $({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function tr(t){const e=new St({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(e.getEditor()).onOK((async()=>{const n=e.getParams();return t.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:e.getStringInput()})),(t=>e.applyStringInput(t.editorSettings))),n.show()}function er(){return new Yt}function nr(){return new Yt}function ir(){return new Yt}function rr(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===a.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);let n=Di.properties?Di.properties.maxMonomerLength:4;if(Rt.gp.maxMonomerLength in t.tags){const e=parseInt(t.getTag(Rt.gp.maxMonomerLength));n=isNaN(e)?n:e}if(".mm.cellRenderer.maxMonomerLength"in t.temp){const e=parseInt(t.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(e)?n:e}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(0==e)setTimeout((()=>{i.value=null}),0);else{const n=e??"",i=null==n?"":n.toString();t.temp[".mm.cellRenderer.maxMonomerLength"]=i,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let r=Di.properties?Di.properties.fontSize:12;".mm.cellRenderer.fontSize"in t.temp&&t.temp[".mm.cellRenderer.fontSize"]&&!isNaN(t.temp[".mm.cellRenderer.fontSize"])&&(r=t.temp[".mm.cellRenderer.fontSize"]);const o=s.input.int("Font Size",{value:r,nullable:!0,min:1,max:50,step:1,onValueChanged:e=>{if(e&&e>0){const n=e??12;t.temp[".mm.cellRenderer.fontSize"]=n,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:t.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.temp[".mm.cellRenderer.settingsChanged"]=Bt.s.true,t.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==t?.temp["color-code"]||t.temp["color-code"],onValueChanged:e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],onValueChanged:e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),d=s.inputs([o,i,l,h,c,u]);return new a.Widget(d)}(t)}function or(t){return(0,li.j)(t,Di.monomerLib,Di.seqHelper)}function sr(){return new Zt}function ar(t,e,n,i,r){const o=new he.$(i,r,n,e);return"Local alignment"==t?o.smithWaterman():o.needlemanWunsch()}function lr(){return new re.oP}function cr(){return new ce}function hr(t,e,n,i){return hi(t,e??null,n??null,i??null)}async function ur(t,e,n,i,r){const s=hi(e,n??null,i??null,r??null);e.dataFrame.columns.add(s),await o.data.detectSemanticTypes(e.dataFrame)}async function dr(t,e,n,i,r,h,u,d,p){if(!(0,Xn.V)(e,"Activity Cliffs"))return;const m=It(t),f={units:e.meta.units,aligned:e.getTag(gt.gp.aligned),separator:e.getTag(gt.gp.separator),alphabet:e.getTag(gt.gp.alphabet)},g=h,y=e,b=async()=>await mt(t,y,m,"Activity cliffs",n,i,g,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,u,me,fe,ve,void 0,p),v=r===c.c.UMAP?2e5:2e4,w=r===c.c.UMAP?5e3:2e3;if(t.rowCount>v)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((e,n)=>{t.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n    Do you want to continue?")).onOK((async()=>{b().then((t=>e(t))).catch((t=>n(t)))})).onCancel((()=>{e(void 0)})).show():b().then((t=>e(t))).catch((t=>n(t)))})).catch((t=>{const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t})).finally((()=>{C.close()}))}async function pr(t,e,n=1,i=.6,r="Morgan"){if(t.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:t.toList(),options:{}};const{seqList:o,options:s}=await de(t,e,r);return{entries:o,options:{...s,gapOpen:n,gapExtend:i}}}async function mr(t,e){t.version!==t.temp["last-invalidated-version"]&&await(0,pe.BQ)(t,Di.seqHelper,!1);const n=t.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let t=0;t<i.length;t++){if(i.isNone(t)||!i.get(t))continue;const e=i.get(t);r[t]=V.A.fromUint32Array(e.length,new Uint32Array(e.getBuffer().buffer))}return{entries:r,options:{}}}async function fr(t,e,i,r,c,h,u,d,p){const m=o.shell.tv.dataFrame==t?o.shell.tv:void 0;if((0,Xn.V)(e,"Sequence Space"))return h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(t,e,i,r,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(e.length!==r.length||e.length!==h.length||e.length!==c.length||e.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??o.shell.tableView(t.name)??o.shell.addTableView(t):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=It(t);function x(n,r,o){let c=null,h=null;t.columns.names().includes(S[0])?(c=t.columns.byName(S[0]),h=t.columns.byName(S[1])):(c=t.columns.add(a.Column.float(S[0],t.rowCount)),h=t.columns.add(a.Column.float(S[1],t.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Tt(e,i)}))),f[l.YP]&&(A?.root&&s.setUpdateIndicator(A.root,!1),c.init((t=>o[0]?o[0][t]:void 0)),h.init((t=>o[1]?o[1][t]:void 0)));const u=n/r*100;C.update(u,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function E(){t.columns.add(a.Column.float(S[0],t.rowCount)),t.columns.add(a.Column.float(S[1],t.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Tt(e,i)}),s.setUpdateIndicator(A.root,!0));const p=o.events.onViewerClosed.subscribe((t=>{const e=t.args.viewer;e?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&e?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(q.S,{}),p.unsubscribe(),n?.(),C.close())})),g=new Promise((async(o,s)=>{try{n=o;const s=[];let a=r,d=c,p=u;if(b&&e.every((t=>t.isNumerical))){const n=e.map((t=>t.toList())),i=new Array(t.rowCount).fill(0).map(((t,n)=>new Float32Array(e.length)));for(let r=0;r<e.length;++r)for(let e=0;e<t.rowCount;++e)i[e][r]=n[r][e];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let t=0;t<h.length;++t){const n=h[t];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:e[t],[o]:r[t],...m.preprocessingFuncArgs[t]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=e[t].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}o(await Y(s.map((t=>t.entries)),i,a,d,u,m,f[l.vb]?void 0:x))}catch(t){s(t)}})),y=await g;return C.close(),p.unsubscribe(),y}const M=await E();if(p&&M){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(t,e,i,r){return _t(this,void 0,void 0,(function*(){return new Promise((function(o,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:t,embedY:e,minPts:r,epsilon:i}),a.onmessage=({data:{error:t,clusters:e}})=>{a.terminate(),t?s(t):o(e)}}))}))}(M[0],M[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),T=t.columns.getUnusedName("Cluster (DBSCAN)");t.columns.addNewString(T).init((t=>I[t].toString())),A&&(A.props.colorColumnName=T)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{_.close()}}if(M){const N=t.columns.byName(S[0]),P=t.columns.byName(S[1]);if(N.init((t=>M[0][t])),P.init((t=>M[1][t])),g)try{const $=g.inputs[0].name,R=g.inputs[1].name;await g.prepare({[$]:N,[R]:P,...y}).call(!0)}catch(O){o.shell.error("Post-processing failed"),console.error(O)}if(A)return s.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(k){o.shell.error("Dimensionality reduction failed"),console.error(k),C.close(),A&&s.setUpdateIndicator(A.root,!1)}};return new Promise((async(e,n)=>{try{if(f.fastRowCount&&t.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const t=await C();e(t)}catch(t){n(t)}})).onCancel((()=>e(void 0))).show();else{const t=await C();e(t)}}catch(t){n(t)}}))}(t,[e],i,[r],[1],[h],"MANHATTAN",c,d??!1,{...u,preprocessingFuncArgs:[u.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:u?.[l.vb],tableView:m})}async function gr(t,e,n,i=!1){const r=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await Ui;const r=e.temp[".mm.cellRenderer.overriddenLibrary"]??Di.monomerLib,o=Di.seqHelper,s=Di.rdKitModule;await(0,mi.V)(t,e,n,i,r,o,s)}finally{r.close()}}async function yr(t){if(!t?.dataFrame)throw new Error("Sequence column is not found or its data frame is not empty");const e=a.Func.find({name:"toAtomicLevel",package:"Bio"})[0];if(!e)throw new Error("To Atomic level Function not found");e.prepare({table:t.dataFrame,seqCol:t}).edit()}async function br(t){return async function(t){const e=s.divText(""),n=a.Widget.fromRoot(e);try{if(!t||!t.value)return e.innerText="No sequence provided",n;if(!(t.cell&&t.cell.dart&&t.cell.dataFrame&&t.cell.column))return e.innerText="Atomic level conversion requeires a sequence column",n;if(![gt.Hi.FASTA,gt.Hi.SEPARATOR,gt.Hi.HELM].includes(t.cell.column.meta.units?.toLowerCase()??""))return e.innerText="Unsupported sequence notation. please use Bio | Polytool | Convert",n;const i=(await lo()).getSeqHandler(t.cell.column);if(!i)return e.innerText="No sequence handler found",n;if((i.getSplitted(t.cell.rowIndex,50)?.length??100)>40)return e.innerText="Maximum number of monomers is 40",n;const r=a.Column.fromStrings("singleVal",[t.value]),l=a.DataFrame.fromColumns([r]);if(Object.entries(t.cell.column.tags).forEach((([t,e])=>{r.setTag(t,e)})),await gr(l,r,t.cell.column.meta.units===gt.Hi.HELM,!1),l.columns.length<2)return e.innerText="No structure generated",n;const c=l.columns.byIndex(1),h=c.get(0);if(!h)return e.innerText="No structure generated",n;c.semType=a.SEMTYPE.MOLECULE;const u=a.SemanticValue.fromTableCell(l.cell(0,c.name)),d=s.panels.infoPanel(u);let p=null;d&&(p=a.Widget.fromRoot(d.root));const m=o.chem.drawMolecule(h,300,300,!1);return m.style.cursor="pointer",s.tooltip.bind(m,"Click to expand"),m.onclick=()=>{const t=window.innerWidth-200,e=window.innerHeight-200,n=o.chem.drawMolecule(h,t,e,!1);s.dialog({title:"Molecule"}).add(n).showModal(!0)},p&&p.root.prepend(m),p??a.Widget.fromRoot(m)}catch(t){Di.logger.error(t)}return e.innerText="No Structure generated",n}(t)}function vr(){(0,Qn.D)({},Di.seqHelper).catch((t=>{const[e,n]=(0,Ct.AP)(t);if(t instanceof Jn.Ap)return o.shell.warning(t.element),void Di.logger.warning(e);o.shell.error(e),Di.logger.error(e,void 0,n)}))}async function wr(t=null,e=null,n){return(0,Qn.D)({col:t,clustersCol:e,...n},Di.seqHelper)}async function Cr(){const t=o.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==a.SEMTYPE.MACROMOLECULE&&(Di.seqHelper.getSeqHandler(t),!0))),n=async e=>{if(!(0,Xn.V)(e,"Composition"))return;const n=t.addViewer("WebLogo",{sequenceColumnName:e.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>Di.seqHelper.getSeqHandler(t).isMsa())),r=s.input.choice("Column",{value:i?i.name:t[0],items:t});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await n(t)})).show()}else i=e[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Ar(t){return new yt.m(t).importFasta()}function Sr(t){return console.log(t),[]}function xr(){const t=(0,$t.me)()[0];(0,_e.C)(t,Di.seqHelper)}function Er(t){(0,_e.C)(t,Di.seqHelper)}function Mr(){return new ri}async function _r(t){const e=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const e=await o.dapi.files.readAsText(t+s.fullPath),n=a.DataFrame.fromCsv(e);for(const t of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:t})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:t.name,message:`units: ${t.meta.units}`})}catch(t){r.push({file:s.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${t}`,s}async function Ir(t,e){return await async function(t,e){if(await(0,te.cb)(10),!(0,Xn.V)(e,"Sequence space"))return t;const n=Di.seqHelper,i=(0,vt.R)(e,n);i.name="splitToMonomers";const r=e.dataFrame;for(const t of i.columns)t.semType=jt.uF.MONOMER,t.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=t=>{s.lastIndex=0;const e=t.match(s);return e?`${e[1]} (${parseInt(e[2]??"0")+1})`:t};for(let t=0;t<i.columns.length;t++){const n=i.columns.byIndex(t);n.semType=jt.uF.MONOMER,n.setTag(wt.gp.alphabet,e.getTag(wt.gp.alphabet));const o=100;let s=0;for(;r.columns.byName(n.name)&&s<o;)n.name=l(n.name),s++;r.columns.add(n)}await o.data.detectSemanticTypes(r);for(let t=0;t<i.columns.length;t++){const e=i.columns.byIndex(t);e.setTag(a.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return r}(t,e)}function Tr(t){return Di.seqHelper.getSeqMonomers(t)}function Lr(){return new Se(Di.seqHelper)}function Nr(){const t=o.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Pr(){return new Ee(Di.seqHelper)}function $r(){const t=o.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Rr(t){const e=(0,$t.me)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new pe.a7(e,Di.seqHelper)}function Or(t){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),o.shell.tv.grid.scrollToCell(t,0)}async function kr(t,e,n){const i=Di.seqHelper;return fi(t,e,n,ft.IDENTITY,i)}async function Gr(t,e,n){const i=Di.seqHelper;return fi(t,e,n,ft.SIMILARITY,i)}async function Fr(){Vn()}async function Hr(){await jn()}async function Br(){const t=await _n.getInstance();await t.getViewRoot()}async function Dr(){return await jn(!1)}async function Vr(t,e){(await(await pn.getInstance()).getFileManager()).getValidLibraryPaths().forEach((e=>{const n=e.endsWith(".json")?e.substring(0,e.length-5):e;t.item(n).onSelected.subscribe((async()=>{const t=await _n.getInstance();await t.getViewRoot(e,!0),t.resetCurrentRowFollowing()}))}))}function jr(){(0,Ie.TE)()}function Ur(){return new Te._i(Di.seqHelper,Di.logger)}function Wr(){return new Te._i(Di.seqHelper,Di.logger)}async function qr(){const t=a.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new ti(t,"webLogoLargeApp"),n=await Di.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function zr(){const t=a.TaskBarProgressIndicator.create("WebLogo ...");try{const t=new URLSearchParams(window.location.search),e=new ti(t,"webLogoAggApp"),n=await Di.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await e.init(n)}finally{t.close()}}async function Yr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new di(t,"getRegionApp");await e.init()}finally{t.close()}}async function Kr(){const t=a.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await Di.files.readCsv("samples/HELM_empty_vals.csv"),n=new di(t,"getRegionHelmApp");await n.init({df:e,colName:"HELM"})}finally{t.close()}}function Zr(){const t=a.DataFrame.fromColumns((0,Lt.dW)());o.shell.addTableView(t)}function Xr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(Di.seqHelper,gt.Hi.FASTA)]);o.shell.addTableView(t)}function Jr(){const t=a.DataFrame.fromColumns([(0,Lt.Hx)(Di.seqHelper,gt.Hi.HELM)]);o.shell.addTableView(t)}function Qr(t,e){!function(t,e,n){const i=n.getSeqHandler(t.column),r=Object.values(gt.Hi).filter((t=>t!==i.units));e.group("Copy").items(r,(e=>{const i=t.column,r=t.rowIndex,s=n.getSeqHandler(i),a=e===gt.Hi.SEPARATOR?Di.properties.defaultSeparator:void 0,l=s.getJoiner({notation:e,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${e}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e,Di.seqHelper)}async function to(){await async function(){const t=await Di.files.readCsv("samples/peptides-non-natural.csv");t.name="Similarity and Diversity Demo",t.col("activity").setTag("format","3 significant digits"),t.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const e=o.shell.addTableView(t);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t);const n=e.addViewer("Sequence Similarity Search",{limit:20}),i=e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,$t.Kd)(e.grid,"sequence",500,30);const r=e.addViewer("Sequence Diversity Search",{limit:20});e.dockManager.dock(r,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function eo(){await async function(){const t=await o.functions.eval("Bio:SeqSpaceDemo"),e=await o.dapi.projects.find(t.id);await e.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function no(){await async function(){const t=await Di.files.readCsv("tests/helm_cyclic_cliffs.csv");t.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(t),await t.meta.detectSemanticTypes();const e=o.shell.addTableView(t);s.setUpdateIndicator(e.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await dr(t,t.getCol("Sequence"),t.getCol("Activity"),96,c.c.UMAP,ue.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),fn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),e.grid.props.rowHeight=180,e.grid.col("sequence")&&(e.grid.col("sequence").width=300),e.grid.col("structure")&&(e.grid.col("structure").width=300);const r=Array.from(e.viewers).find((t=>t!==e.grid&&t.type===a.VIEWER.GRID));r&&(r.props.rowHeight=40,r.col("seq_diff").width=600,e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(t){!function(t){const e=t instanceof Error?t.message:t.toString(),n=t instanceof Error?t.stack:void 0;o.shell.error(e),Di.logger.error(t.message,void 0,n)}(t)}finally{s.setUpdateIndicator(e.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function io(){await async function(){const t=await Di.files.readCsv("samples/HELM_BI_CYCLIC.csv");t.name="To Atomic Level",await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t);const e=o.shell.addTableView(t),n=t.col("HELM");await gr(t,n,!0,!1),(0,$t.Kd)(e.grid,"molfile(HELM)",500,300,!0),(0,$t.Kd)(e.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function ro(t){const e=(0,bt.uX)(t),n=JSON.stringify(e);a.Utils.download(`${t.name}.json`,n)}async function oo(t,e){if(!t.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[t]),i=a.DataFrame.fromColumns([n]),r=await o.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=(await Vi()).getMonomerLib(),l=Di.seqHelper,c=await(0,Pt.j)(),h=(await(0,mi.V)(i,n,e,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(t){const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t}}async function so(t,e){if(!t.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[t]),i=a.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await fi(i,n,e,ft.IDENTITY,Di.seqHelper)).get(0)}catch(t){const[e,n]=(0,Ct.AP)(t);throw Di.logger.error(e,void 0,n),t}}async function ao(t,e,n){const i=await t.readAsString();await async function(t,e,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(t),u=e?h.getCol(e):h.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,te.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,e,n)}async function lo(){return await Wi(),Di.seqHelper}function co(t,e,n){return async function(t,e,n=!0,i){const r=Di.seqHelper,o=(await r.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(e,n,Di.rdKitModule,i);return o.semType=a.SEMTYPE.MOLECULE,o}(0,e,n,Di.monomerLib)}function ho(){return Di.logger.debug("Bio:test1() function"),{value:"value1"}}},6625:(t,e,n)=>{"use strict";n.d(e,{$:()=>o});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{seq1;seq2;score;constructor(t,e,n){this.seq1=t,this.seq2=e,this.score=n}}class o{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let n="",i="",o="";const s=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)o+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(n=o+n,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=o+i,n=this.seq1.substr((t-1)*this.step,this.step)+n):(n=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+n:o+n,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:o+i);const r=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[r][e].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>t&&(t=this.dpGrid[i][r].value,e=i,n=r);return this.constructResult(e,n)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,n,i=""){this.setMethod(i),this.setSequences(t,e),this.setGap(n)}}},8115:(t,e,n)=>{"use strict";n.d(e,{BQ:()=>m,a7:()=>u,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(8070),a=n(2003),l=n(1407),c=n(4870);const h="substr_helm";class u{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(t,e){this.seqHelper=e,this.col=t[0],this.createUI()}editHelmLinkAction(){(0,c.Ku)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const t=this.units===a.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,c.Ku)(this.inputsDiv,t)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const t=this.dialog.root.getElementsByClassName("notation-text")[0];t&&(t.textContent=`Notation: ${this.units}`)}createUI(){const t=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:t,value:this.col,onValueChanged:t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()},filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const e=o.DataFrame.create(1);e.columns.addNewString(h).init((t=>"")),e.col(h).semType=this.col.semType,e.col(h).meta.units=a.Hi.HELM,this.grid=e.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,n=this.units===a.Hi.HELM?e.get(h,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),t=this.units===a.Hi.HELM?await p(n,this.col,this.seqHelper):d(n,this.col),this.col.dataFrame.filter.and(t)})).show()}}function d(t,e,n){const i=n?function(t,e){const n=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,r=t.charAt(t.length-1)===e,o=t.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(t,n):t,r=o.BitSet.create(e.length);for(let n=0;n<e.length;n++){const o=e.get(n);(o.match(i)||o===t)&&r.set(n,!0,!1)}return r}async function p(t,e,n){e.version!==e.temp["last-invalidated-version"]&&await m(e,n,!0);const r=o.Column.string("helm",1).init((e=>t));r.semType=o.SEMTYPE.MACROMOLECULE,r.meta.units=a.Hi.HELM;const s=await(0,l.R)(r,n,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function m(t,e,n){const i=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);try{await(0,s.cb)(10);const i=new Map,r=await(0,l.R)(t,e,n,i);t.temp["monomeric-mols"]=r,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version}finally{i.close()}}},966:(t,e,n)=>{"use strict";n.d(e,{V:()=>s,l:()=>a});var i=n(4328),r=n(6082),o=n(6766);function s(t,e,n=[],r=[],s=!0){const l=o._package.seqHelper,[c,h]=a(t,e,l,n,r);return s&&!c&&i.shell.warning(h),c}function a(t,e,n,o=[],s=[]){let a=!0,l="";if(t.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(t),r=i.notation;if(o.length>0&&!o.some((t=>r.toUpperCase()==t.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==o.length?"any notation":`notation${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const t=i.alphabet;s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(t,e,n)=>{"use strict";n.d(e,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(8152);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(r||(r={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(t){t.CELL_CHANGING="isCellChanging"}(s||(s={})),function(t){t.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(t,e,n)=>{"use strict";n.d(e,{C:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(t,e){let n=t??o.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=e.getSeqHandler(n),u=s.notation;const d=r.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:n,filter:t=>t.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:t=>(n=t,s=e.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((t=>t!==u)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(r.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((t=>t!==u));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const t=v.value,i=t===l.Hi.SEPARATOR?y.value:void 0;await async function(t,e,n,i){const r=e.getSeqHandler(t).convert(n,i);t.dataFrame.columns.add(r);const s=await o.functions.call("Bio:detectMacromolecule",{col:r});return s&&(r.semType=s),await o.data.detectSemanticTypes(t.dataFrame),r}(n,e,t,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((t=>{h.forEach((t=>{t.unsubscribe()})),h=[],c=null}))))}},536:(t,e,n)=>{"use strict";n.d(e,{Z:()=>r});var i=n(6956);class r{constructor(t){const e=t.split(i.xe).filter((t=>t));e.forEach((t=>this.validateConnectionItem(t))),this.connectionItems=e}connectionItems;validateConnectionItem(t){const e="(PEPTIDE|RNA)",n=new RegExp(`${e}[0-9]+,${e}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!t.match(n))throw new Error(`Cannot parse connection item from ${t}`)}getConnectionData(){const t=[];return this.connectionItems.forEach((e=>{const n=[],i=e.split(",");i[2].split("-").forEach(((t,e)=>{const r=i[e],o=t.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),t.push(n)})),t}}},6956:(t,e,n)=>{"use strict";n.d(e,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},9099:(t,e,n)=>{"use strict";n.d(e,{f:()=>s});var i=n(536),r=n(6956),o=n(9034);class s{helmString;constructor(t){this.helmString=t;const e=this.helmString.split(r.pk),n=e[0].split(r.xe);this.simplePolymers=n.map((t=>new o.d(t))),this.connectionList=new i.Z(e[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const t=this.simplePolymers.map((t=>t.monomers.length)).reduce(((t,e)=>t+e),0),e=Array.from({length:t},(()=>[]));return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e[n].push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(t){return this.getSimplePolymerByMonomerIdx(t).polymerType}getSimplePolymerByMonomerIdx(t){const e=this.getMonomerIdxShifts(),n=Object.values(e).sort(((t,e)=>t-e)).find((e=>t>=e));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${t}`);const i=Object.keys(e).find((t=>e[t]===n));return this.simplePolymers.find((t=>t.id===i))}shiftBondMonomerIds(t,e){e.forEach((e=>{e.forEach((e=>{e.monomerIdx+=t}))}))}getMonomerIdxShifts(){const t={};let e=0;return this.simplePolymers.forEach((n=>{t[n.id]=e,e+=n.monomers.length})),t}getBondData(){const t=this.getMonomerIdxShifts(),e=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=t[n.id];this.shiftBondMonomerIds(r,i),e.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((e=>{const n=t[e.polymerId],r=e.bond;r.monomerIdx+=n,i.push(r)})),e.push(i)})),e}}},9034:(t,e,n)=>{"use strict";n.d(e,{d:()=>r});var i=n(8438);class r{simplePolymer;isNucleotideSequence=!1;constructor(t){this.simplePolymer=t,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:e,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=e,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const t=new RegExp("(PEPTIDE|RNA)[0-9]+{"),e=this.simplePolymer.match(t);if(!e)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return e[1]}getIdx(){const t=new RegExp(`${this.polymerType}([0-9]+){`),e=this.simplePolymer.match(t);if(!e)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(e[1])}getMonomerSymbolsAndTypes(){const t=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),e=this.simplePolymer.replace(t,"").split("."),n=[],r=[];return e.forEach((t=>{if(this.isNucleotideSequence){const e=t.split(/\(|\)/).filter((t=>!!t)).map((t=>(0,i.D)(t)));n.push(...e),e.forEach(((t,e)=>r.push(e%3==1?"Branch":"Backbone")))}else n.push((0,i.D)(t)),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const t=[],e=this.monomerTypes.map(((t,e)=>{if("Backbone"===t)return e})).filter((t=>void 0!==t)),n=this.monomerTypes.map(((t,e)=>{if("Branch"===t)return e})).filter((t=>void 0!==t));for(let n=0;n<e.length-1;n++){const i=e[n],r=e[n+1];t.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let e=0;e<n.length;e++){const i=n[e],r=i-1;t.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return t}}},8604:(t,e,n)=>{"use strict";n.d(e,{Es:()=>r,G3:()=>s,gt:()=>o,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",r="System:AppData/Bio/monomer-sets/",o="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(t,e,n)=>{"use strict";n.d(e,{D:()=>_});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),h=n(966),u=n(4139),d=n(5072),p=n.n(d),m=n(7825),f=n.n(m),g=n(7659),y=n.n(g),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=C(),p()(x.A,E),x.A&&x.A.locals&&x.A.locals;var M=n(6766);async function _(t,e){return new Promise((async(n,a)=>{t.clustersCol??=null,t.pepsea??={},t.pepsea.method??=u.HX.pepsea.method,t.pepsea.gapOpen??=u.HX.pepsea.gapOpen,t.pepsea.gapExtend??=u.HX.pepsea.gapExtend;const h=t.col?.dataFrame??i.shell.t,d=t.col??h.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==d){const t="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(t),void a(new l.Ap(o.divText(t)))}const p=o.input.choice("Method",{value:t.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=o.input.float("Terminal gap",{value:t?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=o.p(`Kalign version: ${u.b9}`,"kalign-version"),g=o.input.float("Gap open",{value:t.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=o.input.float("Gap extend",{value:t.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=o.inputs([g,y,m]),v=o.button("Alignment parameters",(()=>{b.hidden=!b.hidden,[g,y,m].forEach((t=>{t.root.style.removeProperty("max-width"),t.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");v.classList.add("msa-params-button"),b.hidden=!0,v.prepend(o.icons.settings((()=>null)));const w=[p.root.style],C=[m.root.style,f.style];let A,S=d;const x=o.input.column("Sequence",{table:h,value:d,onValueChanged:async t=>{if(!t||t.semType!==r.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,s.cb)(0),void(x.value=S);S=t,_.disabled=!1,A=await T(x.value,h,e,w,C,p,E,g,y,m)},filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE});x.setTooltip("Sequences column to use for alignment");const E=o.input.column("Clusters",{table:h,value:t.clustersCol});E.nullable=!0;const M=o.dialog("MSA").add(x).add(E).add(p).add(b).add(v).add(f).onOK((async()=>{await I(x,h,A,n,a)})),_=M.getButton("OK");if(x.fireChanged(),t.col)return A=await T(t.col,h,e,w,C,p,E,g,y,m),void await I(x,h,A,n,a);M.show()}))}async function I(t,e,n,o,s){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(t.fireChanged(),t.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");e.columns.add(a),await i.data.detectSemanticTypes(e),o(a)}catch(t){s(t)}finally{l.close()}}async function T(t,e,n,o,s,d,p,m,f,g){try{if(t.semType!==r.SEMTYPE.MACROMOLECULE)return;const i=e.columns.getUnusedName(`msa(${t.name})`);if((0,h.l)(t,t.name,n,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT])[0]){L(o,s,"kalign"),m.value=null,f.value=null,g.value=null;const e=n.getSeqHandler(t),r=e.isFasta()?t:e.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(r,!1,i,p.value)}if((0,h.l)(t,t.name,n,[a.Hi.HELM],[])[0])return L(o,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(t,i,d.value,m.value,f.value,p.value);if((0,h.l)(t,t.name,n,[a.Hi.SEPARATOR],[a.YI.UN])[0]){const e=n.getSeqHandler(t).convert(a.Hi.HELM);return L(o,s,"pepsea"),m.value??=u.HX.pepsea.gapOpen,f.value??=u.HX.pepsea.gapExtend,async()=>(0,c.GD)(e,i,d.value,m.value,f.value,p.value)}return m.value=null,f.value=null,g.value=null,void L(o,s,"kalign")}catch(t){const e=t instanceof Error?t.message:t.toString();i.shell.error(e),M._package.logger.error(e)}}function L(t,e,n){if("kalign"===n){for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}else{for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}}},608:(t,e,n)=>{"use strict";n.d(e,{Ap:()=>G,aZ:()=>D,eE:()=>H});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),h=Symbol("Comlink.endpoint"),u=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=t=>"object"==typeof t&&null!==t||"function"==typeof t,m=new Map([["proxy",{canHandle:t=>p(t)&&t[c],serialize(t){const{port1:e,port2:n}=new MessageChannel;return f(t,e),[n,[n]]},deserialize:t=>(t.start(),y(t))}],["throw",{canHandle:t=>p(t)&&d in t,serialize({value:t}){let e;return e=t instanceof Error?{isError:!0,value:{message:t.message,name:t.name,stack:t.stack}}:{isError:!1,value:t},[e,[]]},deserialize(t){throw t.isError?Object.assign(new Error(t.value.message),t.value):t.value}}]]);function f(t,e=self){e.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:r,type:o,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const e=s.slice(0,-1).reduce(((t,e)=>t[e]),t),n=s.reduce(((t,e)=>t[e]),t);switch(o){case"GET":l=n;break;case"SET":e[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(e,a);break;case"CONSTRUCT":l=function(t){return Object.assign(t,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:e,port2:n}=new MessageChannel;f(t,n),l=function(t,e){return A.set(t,e),t}(e,[e])}break;case"RELEASE":l=void 0;break;default:return}}catch(t){l={value:t,[d]:0}}Promise.resolve(l).catch((t=>({value:t,[d]:0}))).then((t=>{const[i,s]=S(t);e.postMessage(Object.assign(Object.assign({},i),{id:r}),s),"RELEASE"===o&&(e.removeEventListener("message",n),g(e))}))})),e.start&&e.start()}function g(t){(function(t){return"MessagePort"===t.constructor.name})(t)&&t.close()}function y(t,e){return v(t,[],e)}function b(t){if(t)throw new Error("Proxy has been released and is not useable")}function v(t,e=[],n=function(){}){let i=!1;const r=new Proxy(n,{get(n,o){if(b(i),o===u)return()=>E(t,{type:"RELEASE",path:e.map((t=>t.toString()))}).then((()=>{g(t),i=!0}));if("then"===o){if(0===e.length)return{then:()=>r};const n=E(t,{type:"GET",path:e.map((t=>t.toString()))}).then(x);return n.then.bind(n)}return v(t,[...e,o])},set(n,r,o){b(i);const[s,a]=S(o);return E(t,{type:"SET",path:[...e,r].map((t=>t.toString())),value:s},a).then(x)},apply(n,r,o){b(i);const s=e[e.length-1];if(s===h)return E(t,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(t,e.slice(0,-1));const[a,l]=C(o);return E(t,{type:"APPLY",path:e.map((t=>t.toString())),argumentList:a},l).then(x)},construct(n,r){b(i);const[o,s]=C(r);return E(t,{type:"CONSTRUCT",path:e.map((t=>t.toString())),argumentList:o},s).then(x)}});return r}function w(t){return Array.prototype.concat.apply([],t)}function C(t){const e=t.map(S);return[e.map((t=>t[0])),w(e.map((t=>t[1])))]}const A=new WeakMap;function S(t){for(const[e,n]of m)if(n.canHandle(t)){const[i,r]=n.serialize(t);return[{type:"HANDLER",name:e,value:i},r]}return[{type:"RAW",value:t},A.get(t)||[]]}function x(t){switch(t.type){case"HANDLER":return m.get(t.name).deserialize(t.value);case"RAW":return t.value}}function E(t,e,n){return new Promise((i=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");t.addEventListener("message",(function e(n){!n.data||!n.data.id||n.data.id!==r||(t.removeEventListener("message",e),i(n.data))})),t.start&&t.start(),t.postMessage(Object.assign({id:r},e),n)}))}const M="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{t.config.printStream?postMessage({type:"biowasm",value:{stdout:i}}):e.stdout+=i+`
`},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";t.config.printStream?postMessage({type:"biowasm",value:{[s]:i}}):e[s]+=i+`
`}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",_=typeof window<"u"&&window.Blob&&new Blob([atob(M)],{type:"text/javascript;charset=utf-8"});function I(){const t=_&&(window.URL||window.webkitURL).createObjectURL(_);try{return t?new Worker(t):new Worker("data:application/javascript;base64,"+M)}finally{t&&(window.URL||window.webkitURL).revokeObjectURL(t)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(t,e={}){if(null==t)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(t)||(t=[t]),e=Object.assign({},T,e),t=t.map(this._parseTool),"stg"===e.env&&(e.urlCDN=e.urlCDNStg),this.tools=t,this.config=e,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const t=new I;this.callback&&(t.onmessage=t=>{"biowasm"===t.data.type&&this.callback(t.data.value)});const e=y(t);return e.tools=this.tools,e.config=this.config,await e.init(),e}_parseTool(t){if("string"!=typeof t)return t;const e=t.split("/");if(2!=e.length&&3!=e.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:e[0],program:3==e.length?e[1]:e[0],version:e[e.length-1]}}}var N=n(3629);class P{static getAvailableScales(){return Object.entries(this.scales).map((([t,e])=>t))}static getScale(t){return(0,N.vA)(!(void 0===this.scales[t]),`Scale '${t}' was not found.`),this.scales[t]}}P.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class ${constructor(t="categorial"){this.aa2num=P.getScale(t),this.num2aa={},Object.entries(this.aa2num).forEach((([t,e])=>this.num2aa[e]=t))}static _truncateSequence(t){let e=0,n=t.length;const i=["NH2","COOH"];if(t.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==t[n],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=n}if(t.endsWith(i[1])){const e=i[1].length+1;(0,N.vA)("-"==t[n-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),n-=e}return t.substring(e,n)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return $._dropDefises($._truncateSequence(t))}encode(t){const e=t.length,n=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,N.vA)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),n[i]=this.encodeLettter(e)}return n}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let n=0;n<t.length;++n){const i=t[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(t,e){super(t.innerText,e),this.element=t}}function F(t){return t.reduce(((t,e,n)=>t+`>sample${n+1}\n${e}\n`),"")}async function H(t,e=!1,n="",i=null,o,s,c){let h=t.toList();e&&(h=h.map((t=>$.clean(t).replace(/\-/g,""))));const u=t.length;i??=r.Column.string("Clusters",u).init("0"),i.type!=r.COLUMN_TYPE.STRING&&(i=i.convertTo(r.TYPE.STRING)),i.compact();const d=i.categories,p=i.getRawData(),m=new Array(d.length),f=new Array(d.length);for(let t=0;t<u;++t){const e=p[t];(m[e]??=[]).push(h[t]),(f[e]??=[]).push(t)}D(f,d);const g=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=r.Column.string(n,u);for(let t=0;t<d.length;++t){const e=F(m[t]);await g.fs.writeFile(O,e);const n=`${void 0!==o?` --gpo ${o}`:""}${void 0!==s?` --gpe ${s}`:""}${void 0!==c?` --tgpe ${c}`:""}`,i=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(i);const r=await g.cat(k);if(!r){const t=B(i,1);throw new Error(t)}const l=new a.m(r).sequencesArray,h=f[t];for(let t=0;t<l.length;++t)y.set(h[t],l[t])}const b=t.meta.units,v=t.getTag(l.gp.alphabet);return y.meta.units=b,y.setTag(l.gp.aligned,"SEQ.MSA"),y.setTag(l.gp.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(t,e){const n=[],i=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=i.exec(t))&&(void 0===e||n.length<e);)n.push(r[1]);return n.join("\n")}function D(t,e){const n=t.map(((t,e)=>[t,e])).filter((([t,e])=>1==t.length)).map((([t,e])=>e));if(n.length>0){const t=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((t=>{let r=e[t];return r.length>25&&(r=r.slice(0,25)+"..."),i.divText(`"${r}"${t<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new G(t)}}},8152:(t,e,n)=>{"use strict";n.d(e,{GD:()=>d,ZY:()=>h});var i=n(4328),r=n(6082),o=n(2003),s=n(608),a=n(4139),l=n(6766);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],u=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(t,e,n="ginsi",i=1.53,l=0,h=null,d){const m=await c.getDockerContainer(),f=t.length;h??=r.Column.int("Clusters",f).init(0),h.type!=r.COLUMN_TYPE.STRING&&(h=h.convertTo(r.TYPE.STRING));const g=h.categories,y=h.getRawData(),b=new Array(g.length),v=new Array(g.length);for(let e=0;e<f;++e){const n=y[e],i=g[n];if(""===i)continue;const r=g.indexOf(i),o=t.get(e);o&&((b[r]??=[]).push({ID:e.toString(),HELM:o}),(v[n]??=[]).push(e))}(0,s.aZ)(v,g);const w=new Array(f);for(const t of b){const e=(await p(m.id,t,n,i,l,d)).Alignment;for(const t of e)w[parseInt(t.ID)]=Object.entries(t).filter((t=>!u.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(a.J.SEPARATOR)}const C=r.Column.fromStrings(e,w);return C.meta.units=o.Hi.SEPARATOR,C.setTag(o.gp.separator,a.J.SEPARATOR),C.setTag(o.gp.aligned,"SEQ.MSA"),C.setTag(o.gp.alphabet,o.YI.UN),C.setTag(o.gp.alphabetIsMultichar,"true"),C.semType=r.SEMTYPE.MACROMOLECULE,C}async function p(t,e,n,r,o,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},c=`/align?method=${n}&gap_open=${r}&gap_extend=${o}`,h=window.performance.now(),u=await i.dapi.docker.dockerContainers.fetchProxy(t,c,a),d=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${d-h} ms`);const p="application/json"===u.headers.get("content-type");if(!u.ok&&p){const t=await u.json(),e=t["pepsea-error"];if(e)throw new Error(`PepSeA error: ${e}`);const n=t["datagrok-error"];if(n)throw new Error(`Datagrok error: ${n}`);throw new Error(u.statusText)}if(!u.ok&&!p){const t=await u.text();throw new Error(`Error: ${t}`)}if(!p){const t=await u.text();throw new Error(`Error: PepSeA expected JSON response, got '${t}'.`)}const m=await u.json();if("pepsea-stderr"in m){const t=m["pepsea-stderr"];s?.warning(t)}return m}},3890:(t,e,n)=>{"use strict";n.d(e,{TE:()=>h});var i=n(6082),r=n(7389),o=n(4328),s=n(1991),a=n.n(s),l=n(6766);const c=60;function h(){const t=o.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],h=r.input.multiChoice("Seq id columns",{value:s,items:e.map((t=>t.name))}),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&l._package.seqHelper.getSeqHandler(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=r.input.choice("Seq column",{value:p,items:d.map((t=>t.name))}),f=r.input.int("FASTA line width",{value:c});r.dialog({title:"Save as FASTA"}).add(r.inputs([h,m,f])).onOK((()=>{const e=h.value?h.value.map((e=>t.columns.byName(e).column)):[],n=m.value?t.columns.byName(m.value).column:null,i=f.value??c;n||o.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(t,e,n=c,i="\n"){const r=[];for(let o=0;o<e.length;o++){const s=t.map((t=>t.get(o).toString())).join("|"),a=u(e.getSplitted(o),n);r.push(`>${s}${i}`);for(const t of a)r.push(`${t}${i}`)}return"".concat(...r)}(e,l._package.seqHelper.getSeqHandler(n),i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),s.setAttribute("download",`${t.dataFrame.name}.fasta`),s.click()})).show()}function u(t,e=c){let n=0;const i=t.length,r=[];for(;n<i;){const i=a().count(n).take(Math.min(t.length-n,e)).map((e=>t.getOriginal(e))).toArray(),o=i.map((t=>t.length>1?`[${t}]`:t)).reduce(((t,e)=>t+e),"");r.push(o),n+=i.length}return r}},8754:(t,e,n)=>{"use strict";n.d(e,{V:()=>h});var i=n(4328),r=n(6077),o=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function h(t,e,n,h,u,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(e);let r,a;i.isHelm()?r=e:(a=e.name,e.name=`__${a}`,r=i.convert(o.Hi.HELM),r.name=a,t.columns.add(r,!1));try{m=await n.helmToAtomicLevel(r,!0,!0,u)}finally{r!==e&&(t.columns.remove(r.name),e.name=a)}}else{if(!(0,l.l)(e,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,r.C4)(t,e,u,d,p)}if(m.molCol){const r=(0,c.qj)(t,e.name);m.molCol.name=r,t.columns.add(m.molCol,!0),await(0,a.Qc)(e,m.molCol,u,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(h)),await i.data.detectSemanticTypes(t)}return m}},4870:(t,e,n)=>{"use strict";n.d(e,{Kd:()=>a,Ku:()=>s,me:()=>o});var i=n(4328),r=n(6082);function o(){const t=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);return null===t?(i.shell.error("Current table does not contain macromolecules"),[]):t}function s(t,e){t.innerHTML="",t.append(e)}function a(t,e,n,i,r){const o=()=>{const r=t.col(e);r&&(r.width=n),i&&(t.props.rowHeight=i)};if(r)return void o();const s=t.onAfterDrawOverlay.subscribe((()=>{s.unsubscribe(),setTimeout((()=>{o()}))}))}},250:(t,e,n)=>{"use strict";n.d(e,{n5:()=>v,oP:()=>I});var i=n(4328),r=n(7389),o=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),h=n(1858),u=n(2003),d=n(4326);function p(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?p(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var m=n(8070),f=n(7602),g=n(439),y=n(6882);var b,v,w=n(2174),C=n(6766);function A(t,e,n){return Math.abs(t-e)<=n}HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const n=this.getBoundingClientRect();return new o.Point((t.clientX-n.left)*e,(t.clientY-n.top)*e)},o.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class S{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(t=0,e){this.value=this.rowCount=t,this.bounds=e}push(t){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=t,++this.valueIdx}aggregate(t){this.value=t(this.valueList)??0,this.valueList=null}}class x{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(t,e,n,i){this.pos=t,this.name=e,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new S),e}aggregate(t){const e=function(t){return e=>{const n=function(t){let e;const n="agg";return e=t instanceof Float32Array?o.Column.fromFloat32Array(n,t):t instanceof Int32Array?o.Column.fromInt32Array(n,t):o.Column.fromList(o.COLUMN_TYPE.FLOAT,n,t),e}(e);return n.aggregate(t)}}(t);for(const[t,n]of Object.entries(this._freqs))n.aggregate(e)}getMinValue(){return Math.min(...Object.values(this._freqs).map((t=>t.value)))}calcPlotValue(t){for(const e of Object.values(this._freqs))e.plotValue=e.value-t}calcHeights(t){this.sumPlotValue=0;for(const t of Object.values(this._freqs))this.sumPlotValue+=t.plotValue;if(this.sumPlotValueForHeight=0,t===d.fH.Entropy){const t=Object.keys(this._freqs).length,e=.01*this.sumPlotValue,n=e/t;for(const t of Object.values(this._freqs)){const i=(t.plotValue+n)/(this.sumPlotValue+e);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(t===d.fH.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=t}}calcScreen(t,e,n,i,r,s,a,l,c){const h=i===d.fH.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let u=c*l+(n-h-1);const p=Object.entries(this._freqs).sort(((t,e)=>t[0]!==g._S&&e[0]!==g._S?e[1].value-t[1].value:t[0]===g._S&&e[0]===g._S?0:t[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((t-e)*l*s,u,a*l,n),u+=n}}render(t,e,n,i,r,o,s){for(const[a,l]of Object.entries(this._freqs))if(a!==g._S){const c=(0,u.zS)(a,s),h=l.bounds,d=h.left;let p=y.S$;o&&(p=o.getMonomerTextColor(r,a)),t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(d,h.top,h.width,h.height),t.fillStyle=p,t.textAlign="left",t.font=e;const m=t.measureText(c);t.setTransform(h.width/m.width,0,0,h.height/i,d,h.top),t.fillText(c,0,-n)}}getMonomerAt(t,e){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(t,e)));return n?n[0]:void 0}buildCompositionTable(t,e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w.F)(Object.assign({},...Object.entries(this._freqs).map((([t,e])=>({[t]:e.rowCount})))),t,e)}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(b||(b={})),function(t){t.sequenceColumnName="sequenceColumnName",t.valueAggrType="valueAggrType",t.valueColumnName="valueColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.maxMonomerLetters="maxMonomerLetters",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(v||(v={}));const E=d.Fo;var M;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(M||(M={}));const _=new class{render=20};class I extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;maxMonomerLetters;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=C._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,E.sequenceColumnName,{category:b.DATA,semType:o.SEMTYPE.MACROMOLECULE,description:"Column with sequences"});const t=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],e=Object.values(o.AGG).filter((e=>!t.includes(e)));this.valueColumnName=this.string(v.valueColumnName,E.valueColumnName,{category:b.DATA,columnTypeFilter:"numerical",description:"Column with values used in aggregation for position heights"}),this.valueAggrType=this.string(v.valueAggrType,E.valueAggrType,{category:b.DATA,choices:e,description:"Aggregation method for value column"}),this.startPositionName=this.string(v.startPositionName,E.startPositionName,{category:b.DATA,description:"Position or column name for start position. If column with given name is found, its values will be used as start position. If number is supplied, it will be used as start position of WebLogo."}),this.endPositionName=this.string(v.endPositionName,E.endPositionName,{category:b.DATA,description:"Position or column name for end position. If column with given name is found, its values will be used as end position. If number is supplied, it will be used as end position of WebLogo."}),this.skipEmptySequences=this.bool(v.skipEmptySequences,E.skipEmptySequences,{category:b.DATA,description:"Skip sequences which are empty in all positions"}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,E.skipEmptyPositions,{category:b.DATA,description:"Skip positions which are empty in all sequences"}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,E.shrinkEmptyTail,{category:b.DATA,description:"Skip empty tail (if found for all sequences within a subset) in WebLogo"}),this.backgroundColor=this.int(v.backgroundColor,E.backgroundColor,{category:b.STYLE,description:"Background color of WebLogo canvas"}),this.positionHeight=this.string(v.positionHeight,E.positionHeight,{category:b.STYLE,choices:Object.values(d.fH),description:"Monomer-Position height mode. Entropy of 100%(full height)"}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,E.positionWidth,{category:b.LAYOUT,editor:"slider",min:4,max:100,description:'Width of position in WebLogo. If "Fit Area" is enabled, width will be calculated to fit horizontal space'}),this.verticalAlignment=this.string(v.verticalAlignment,E.verticalAlignment,{category:b.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,E.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(v.fixWidth,E.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,E.fitArea,{category:b.LAYOUT,description:"Fit WebLogo to the horizontal space. Calculates position width as maximum between provided width value and value needed to fit whole horizontal space."}),this.minHeight=this.int(v.minHeight,E.minHeight,{category:b.LAYOUT,editor:"slider",min:10,max:250,description:"Minimum height of WebLogo"}),this.maxHeight=this.int(v.maxHeight,E.maxHeight,{category:b.LAYOUT,editor:"slider",min:25,max:Math.max(window.innerHeight??0,1e3),nullable:!0,description:"Maximum height of WebLogo"}),this.maxMonomerLetters=this.int(v.maxMonomerLetters,E.maxMonomerLetters,{category:b.LAYOUT,editor:"slider",min:1,max:40,description:"Maximum monomer letters to display before shortening"}),this.showPositionLabels=this.bool(v.showPositionLabels,E.showPositionLabels,{category:b.LAYOUT,description:"Show position labels on top of the weblogo"}),this.positionMarginState=this.string(v.positionMarginState,E.positionMarginState,{category:b.LAYOUT,choices:Object.values(d.mH),description:"Calculate optimal margins between positions or turn it on/off"});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:25,description:"Margin between positions in WebLogo"}),this.filterSource=this.string(v.filterSource,E.filterSource,{category:b.BEHAVIOR,choices:Object.values(d.lT),description:"Data source for weblogo. Selected or filtered rows."}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,C.getMonomerLibHelper)().then((t=>{this.monomerLib=t.getMonomerLib(),this.render(M.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(M.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(C._package.logger)}static viewerCounter=-1;viewerId=++I.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const t=`${this.toLog()}.setData()`;C._package.logger.debug(`${t}, in`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${t}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(M.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(t){const e={width:t.target.clientWidth,height:t.target.clientHeight};this.lastSize.width==e.width&&this.lastSize.height==e.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(e)}, start `),this.render(M.Layout,"rootOnSizeChanged")),this.lastSize=e}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((t=>t.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(M.Freqs,"updateSeqCol()"),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let t;switch(this.filterSource){case d.lT.Filtered:t=this.dataFrame.filter;break;case d.lT.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=n*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;let e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e);this.fitArea&&e<this.root.clientWidth&&(this._positionWidth=Math.floor(this._positionWidth*this.root.clientWidth/e),this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,e=this._positionWidthWithMargin*this.Length,n=Math.min(this.root.clientWidth,e));const i=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${i}px`,this.host.style.width=`${this.root.clientWidth}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+8}px`);const r=e>n;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.canvas.style.height=i-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.canvas.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*t,this.canvas.height=i*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight??this.root.clientHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+n,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-n),this.safeUpdateSlider(0,Math.max(0,this.Length-.001),t,e)}else this.safeUpdateSlider(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}safeUpdateSlider(t,e,n,i){A(t,this.slider.minRange,.1)&&A(e,this.slider.maxRange,.1)&&A(n,this.slider.min,.1)&&A(i,this.slider.max,.1)||this.slider.setValues(t,e,n,i)}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(M.Freqs,`onPropertyChanged( ${t.name} )`);break;case v.minHeight:case v.maxHeight:case v.maxMonomerLetters:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(M.Layout,`onPropertyChanged(${t.name})`);break;case v.backgroundColor:this.render(M.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const t=`${this.toLog()}.detach()`;C._package.logger.debug(`${t}, in`);const e=super.detach.bind(this);this.viewSyncer.sync(`${t}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),e())})),C._package.logger.debug(`${t}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const n=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,t.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((t=>!t.hasMonomer(g._S)||t.getFreq(g._S).rowCount!==t.sumRowCount)).toArray())}requestedRenderLevel=M.Freqs;renderRequest=new h.Subject;renderRequestSub;render(t,e){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(t>=M.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.seqCol.getTag(u.gp.positionNames),e=this.seqCol.getTag(u.gp.positionLabels);let n;!t&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):t&&this.endPositionName&&(n=t.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((t=>{const e=this.seqHandler.getSplitted(t,n);return i.get(t)&&e?e.length:0})).reduce(((t,e)=>Math.max(t,e)),0);this.positionNames=t?t.split(u.z1).map((t=>t.trim())):[...Array(r).keys()].map((t=>`${t+1}`)),this.positionLabels=e?e.split(u.z1).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let t=0;t<s;t++){const e=this.positionNames[this.startPosition+t],n=this.positionLabels?this.positionLabels[this.startPosition+t]:void 0;this.positions[t]=new x(this.startPosition+t,e,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let t=0;t<s;++t){for(const e of l){const n=this.seqHandler.getSplitted(e),i=t+this.startPosition<n.length?n.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?g._S:i,o=this.positions[t],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let e=null;try{e=this.dataFrame.getCol(this.valueColumnName),e.matches("numerical")||(e=null)}catch{e=null}if(e){for(const n of l){const i=this.seqHandler.getSplitted(n),r=t+this.startPosition<i.length?i.getCanonical(this.startPosition+t):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===r?g._S:r,s=e.get(n);this.positions[t].getFreq(o).push(s)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((t=>t.getMinValue()))));for(let t=0;t<s;++t)this.positions[t].calcPlotValue(h),this.positions[t].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));t>=M.Layout&&((t,e,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const t=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==t&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(t)}else a=Math.max(...c().count(t).takeWhile((t=>t<=e)).map((t=>this.positions[t].sumPlotValueForHeight)));for(let i=t;i<=e;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(t){const e=o.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const t=10*e;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${t.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(t,e,n,i,r,o,s,a){t.save();try{t.textAlign="center";let l=null,c=null;for(let e=Math.floor(s);e<=Math.floor(a);e++){const n=o[e],i=t.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const h=l<i*e-2?1:(i*e-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],u=(l-s)*n*e+i*e/2,d=(r*e-c)/2;t.setTransform(h,0,0,1,u,d),t.measureText(a.label),t.fillText(a.label,0,0)}}finally{t.restore()}}(a,e,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let t=r;t<=s;t++)this.positions[t].render(a,i,l,c,h,this.monomerLib,this.maxMonomerLetters)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${t} ), end`)}}renderRequestOnDebounce(t){const e=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=M.None,this.viewSyncer.sync(e,(async()=>{await this.renderInt(t)}))):C._package.logger.warning(`${e}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};if(this.canvas&&this.canvas.offsetWidth>0&&(this._positionWidthWithMargin??0)>0){const e=t.max-t.min,n=this.canvas.offsetWidth/e-this.positionMarginValue;A(n,this.positionWidth,.1)?this.render(M.Layout,"sliderOnValuesChanged"):this.getProperty(v.positionWidth)?.set(this,n)}}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(M.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(M.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){if(!this.monomerLib||!this.seqHandler)return;const e=window.devicePixelRatio;try{const n=t,i=this.canvas.getCursorPosition(n,e),[s,a]=this.getMonomer(i,e),l=this.showPositionLabels?12*e:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const t=[r.divText(`Position ${s.label}`)];if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.seqHandler.defaultBiotype;t.push(s.buildCompositionTable(e,this.monomerLib))}const e=r.divV(t);e.style.maxHeight="80vh",r.tooltip.show(e,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=s.getFreq(a),e=[r.div(`${a}`),r.div(`${t.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&e.push(r.div(`${this.valueAggrType}: ${t.value.toFixed(3)}`));const i=r.divV(e);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(e,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const t=o.BitSet.create(this.dataFrame.selection.length,(t=>function(t,e,n,i,r,o){const s=e.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),t,r,i)));this.dataFrame.selection.init((e=>t.get(e)))}}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=p(t);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+e)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`invalidate(${t?` <- ${t} `:""})`,n=`${this.toLog()}.${e}`;this.render(M.None,e),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(t=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),t);const e=this.viewSyncer.resetErrors();if(e.length>0)throw e[0]}}},1687:(t,e,n)=>{"use strict";n.d(e,{_i:()=>x});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(8115),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(6766);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(t){super(),this.seqHelper=t,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const t of this.viewSubs)t.unsubscribe()}async attach(){this.viewerToLog();try{const t=await(0,g.b2)();let e,n;this.helmEditor=t.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{e=i.div(),n=t.createWebEditorApp(e,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{try{const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(t,void 0,v._package.logger)}catch(t){this.logger.error(t)}finally{f()(e).empty(),e=null,n=null}})).onCancel((()=>{f()(e).empty(),e=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((t=>{try{if(n){const t=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(t)}}catch(t){const[e,n]=(0,y.AP)(t);this.logger.error(e,void 0,n)}})))}catch(t){const[e,n]=(0,y.AP)(t),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,e)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(t){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=e/2;if(t)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,n);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,t)}}async substructureSearch(t){const e=`${this.viewerToLog()}.substructureSearch( column = <${t.name}> )`;v._package.logger.debug(`${e}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,t,this.seqHelper)}finally{v._package.logger.debug(`${e}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(t,e,n,i,r){this.props=t,this.filterId=e,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class S extends p.n{separator;constructor(t,e,n){super(t,!1,n),this.separator=e,this.readOnly=!0}}class x extends r.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(t,e){super(),this.seqHelper=t,this.logger=e,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(t){const e=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{e(t),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=t.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const t=super.detach.bind(this),e=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(e,(async()=>{for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[],t(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(t){t.filterId!==this.filterId&&t.dataFrameId===this.dataFrame.id&&t.columnName===this.columnName&&(this.bioFilter.props=t.props)}applyFilter(){const t=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${t}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=`${this.filterToLog()}.saveState()`,e=super.saveState();return this.logger.debug(`${t}, super.state = ${JSON.stringify(e)}`),e.props=this.bioFilter.saveProps(),e}applyState(t){const e=`${this.filterToLog()}.applyState()`;super.applyState(t),this.filterSyncer.sync(e,(async()=>{t.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(t.props??{}))}))}fireFilterSync(){const t=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${t}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const t=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${t}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(t,(async()=>{this.calculating=!0;try{this.logger.debug(`${t}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${t}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${t}, end`)}}))}grokEventsOnResetFilterRequest(){const t=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${t}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(t){const e=`${this.filterToLog()}.invalidate(${t?` <- ${t} `:""})`;this.filterSyncer.sync(e,(async()=>{this._onRendered.next()}))}async awaitRendered(t=1e4){const e=`awaitRendered( ${t} )`,n=`${this.filterToLog()}.${e}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(e)}),t,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{window.setTimeout((()=>{this.props=new p.n(t,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(t){return(0,d.nI)(this.props.substructure,t)}async attach(){}async detach(){await super.detach()}}class M extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(t){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:t=>{this.props=new S(t,this.props.separator,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=t,onValueChanged:t=>{const e=t||"";this.props=new S(this.props.substructure,e,v._package.logger),setTimeout((()=>{this._propsChanging||this.onChanged.next()}))},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const t=this.props.separator??this.colSeparator;this.separatorInput.value!==t&&(this.separatorInput.value=t)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,d.nI)(this.substructure,t,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(t,e,n)=>{"use strict";n.d(e,{F:()=>E,j:()=>x});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(439),c=n(3599),h=n(5072),u=n.n(h),d=n(7825),p=n.n(d),m=n(7659),f=n.n(m),g=n(5056),y=n.n(g),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(5999),S={};function x(t,e,n){const o=i.div();o.classList.add("macromolecule-cell-comp-analysis-host");const l=t.cell.column.tags[a.gp.alphabet],h=l===a.YI.DNA||l===a.YI.RNA?c.o.NUCLEOTIDE:c.o.AA,u={},d=n.getSeqHandler(t.cell.column),p=t.cell.rowIndex,m=d.getSplitted(p);s().count(0).take(m.length).filter((t=>!m.isGap(t))).forEach((t=>{let e=m.getCanonical(t);h===c.o.NUCLEOTIDE&&d.isHelm()&&"("===e[1]&&")"===e[e.length-2]&&(e=e.substring(2,e.length-2));const n=u[e]||0;u[e]=n+1}));const f=E(u,h,e);return Array.from(f.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),o.appendChild(f),new r.Widget(o)}function E(t,e,n){let o=0,s=null;for(const e of Object.values(t))o+=e,s=null===s?e:Math.max(s,e);const a=s/o,c=Object.assign({},...Array.from(Object.entries(t)).sort(((t,e)=>e[1]-t[1])).map((([t,s])=>{const c=s/o,h=n.getWebEditorMonomer(e,t).backgroundcolor,u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/a+"px",u.style.backgroundColor=h,l._S===t&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=r.Color.toHtml(r.Color.lightGray));const d=l._S===t?"-":t,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),h}S.styleTagTransform=C(),S.setAttributes=y(),S.insert=f().bind(null,"head"),S.domAPI=p(),S.insertStyleElement=v(),u()(A.A,S),A.A&&A.A.locals&&A.A.locals},1757:t=>{"use strict";t.exports=$},6082:t=>{"use strict";t.exports=DG},4328:t=>{"use strict";t.exports=grok},1858:t=>{"use strict";t.exports=rxjs},9713:t=>{"use strict";t.exports=rxjs.operators},7389:t=>{"use strict";t.exports=ui},1991:t=>{"use strict";t.exports=wu},8343:(t,e,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:r,removeDotSegments:o,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(t,e,n,i){const r={};return i||(t=p(h(t,n),n),e=p(h(e,n),n)),!(n=n||{}).tolerant&&e.scheme?(r.scheme=e.scheme,r.userinfo=e.userinfo,r.host=e.host,r.port=e.port,r.path=o(e.path||""),r.query=e.query):(void 0!==e.userinfo||void 0!==e.host||void 0!==e.port?(r.userinfo=e.userinfo,r.host=e.host,r.port=e.port,r.path=o(e.path||""),r.query=e.query):(e.path?("/"===e.path.charAt(0)?r.path=o(e.path):(void 0===t.userinfo&&void 0===t.host&&void 0===t.port||t.path?t.path?r.path=t.path.slice(0,t.path.lastIndexOf("/")+1)+e.path:r.path=e.path:r.path="/"+e.path,r.path=o(r.path)),r.query=e.query):(r.path=t.path,void 0!==e.query?r.query=e.query:r.query=t.query),r.userinfo=t.userinfo,r.host=t.host,r.port=t.port),r.scheme=t.scheme),r.fragment=e.fragment,r}function h(t,e){const n={host:t.host,scheme:t.scheme,userinfo:t.userinfo,port:t.port,path:t.path,query:t.query,nid:t.nid,nss:t.nss,uuid:t.uuid,fragment:t.fragment,reference:t.reference,resourceName:t.resourceName,secure:t.secure,error:""},i=Object.assign({},e),r=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&r.push(n.scheme,":");const c=s(n);if(void 0!==c&&("suffix"!==i.reference&&r.push("//"),r.push(c),n.path&&"/"!==n.path.charAt(0)&&r.push("/")),void 0!==n.path){let t=n.path;i.absolutePath||a&&a.absolutePath||(t=o(t)),void 0===c&&(t=t.replace(/^\/\//u,"/%2F")),r.push(t)}return void 0!==n.query&&r.push("?",n.query),void 0!==n.fragment&&r.push("#",n.fragment),r.join("")}const u=Array.from({length:127},((t,e)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(e)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(t,e){const n=Object.assign({},e),o={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==t.indexOf("%");let a=!1;"suffix"===n.reference&&(t=(n.scheme?n.scheme+":":"")+"//"+t);const c=t.match(d);if(c){if(o.scheme=c[1],o.userinfo=c[3],o.host=c[4],o.port=parseInt(c[5],10),o.path=c[6]||"",o.query=c[7],o.fragment=c[8],isNaN(o.port)&&(o.port=c[5]),o.host){const t=r(o.host);if(!1===t.isIPV4){const e=i(t.host);o.host=e.host.toLowerCase(),a=e.isIPV6}else o.host=t.host,a=!0}void 0!==o.scheme||void 0!==o.userinfo||void 0!==o.host||void 0!==o.port||void 0!==o.query||o.path?void 0===o.scheme?o.reference="relative":void 0===o.fragment?o.reference="absolute":o.reference="uri":o.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==o.reference&&(o.error=o.error||"URI is not a "+n.reference+" reference.");const t=l[(n.scheme||o.scheme||"").toLowerCase()];if(!(n.unicodeSupport||t&&t.unicodeSupport)&&o.host&&(n.domainHost||t&&t.domainHost)&&!1===a&&function(t){let e=0;for(let n=0,i=t.length;n<i;++n)if(e=t.charCodeAt(n),e>126||u[e])return!0;return!1}(o.host))try{o.host=URL.domainToASCII(o.host.toLowerCase())}catch(t){o.error=o.error||"Host's domain name can not be converted to ASCII: "+t}(!t||t&&!t.skipNormalize)&&(s&&void 0!==o.scheme&&(o.scheme=unescape(o.scheme)),s&&void 0!==o.host&&(o.host=unescape(o.host)),o.path&&(o.path=escape(unescape(o.path))),o.fragment&&(o.fragment=encodeURI(decodeURIComponent(o.fragment)))),t&&t.parse&&t.parse(o,n)}else o.error=o.error||"URI can not be parsed.";return o}const m={SCHEMES:l,normalize:function(t,e){return"string"==typeof t?t=h(p(t,e),e):"object"==typeof t&&(t=p(h(t,e),e)),t},resolve:function(t,e,n){const i=Object.assign({scheme:"null"},n);return h(c(p(t,i),p(e,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(t,e,n){return"string"==typeof t?(t=unescape(t),t=h(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=h(a(t,!0),{...n,skipEscape:!0})),"string"==typeof e?(e=unescape(e),e=h(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=h(a(e,!0),{...n,skipEscape:!0})),t.toLowerCase()===e.toLowerCase()},serialize:h,parse:p};t.exports=m,t.exports.default=m,t.exports.fastUri=m},343:t=>{"use strict";const e=/^[\da-f]{8}-[\da-f]{4}-[\da-f]{4}-[\da-f]{4}-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(t){return"boolean"==typeof t.secure?t.secure:"wss"===String(t.scheme).toLowerCase()}function r(t){return t.host||(t.error=t.error||"HTTP URIs must have a host."),t}function o(t){const e="https"===String(t.scheme).toLowerCase();return t.port!==(e?443:80)&&""!==t.port||(t.port=void 0),t.path||(t.path="/"),t}const s={scheme:"http",domainHost:!0,parse:r,serialize:o},a={scheme:"ws",domainHost:!0,parse:function(t){return t.secure=i(t),t.resourceName=(t.path||"/")+(t.query?"?"+t.query:""),t.path=void 0,t.query=void 0,t},serialize:function(t){if(t.port!==(i(t)?443:80)&&""!==t.port||(t.port=void 0),"boolean"==typeof t.secure&&(t.scheme=t.secure?"wss":"ws",t.secure=void 0),t.resourceName){const[e,n]=t.resourceName.split("?");t.path=e&&"/"!==e?e:void 0,t.query=n,t.resourceName=void 0}return t.fragment=void 0,t}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:r,serialize:o},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(t,e){if(!t.path)return t.error="URN can not be parsed",t;const i=t.path.match(n);if(i){const n=e.scheme||t.scheme||"urn";t.nid=i[1].toLowerCase(),t.nss=i[2];const r=`${n}:${e.nid||t.nid}`,o=l[r];t.path=void 0,o&&(t=o.parse(t,e))}else t.error=t.error||"URN can not be parsed.";return t},serialize:function(t,e){const n=e.scheme||t.scheme||"urn",i=t.nid.toLowerCase(),r=`${n}:${e.nid||i}`,o=l[r];o&&(t=o.serialize(t,e));const s=t,a=t.nss;return s.path=`${i||e.nid}:${a}`,e.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(t,n){const i=t;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&e.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(t){const e=t;return e.nss=(t.uuid||"").toLowerCase(),e},skipNormalize:!0}};t.exports=l},4914:t=>{"use strict";t.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(t,e,n)=>{"use strict";const{HEX:i}=n(4914),r=/^(?:(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)\.){3}(?:25[0-5]|2[0-4]\d|1\d{2}|[1-9]\d|\d)$/u;function o(t){if(c(t,".")<3)return{host:t,isIPV4:!1};const e=t.match(r)||[],[n]=e;return n?{host:l(n,"."),isIPV4:!0}:{host:t,isIPV4:!1}}function s(t,e=!1){let n="",r=!0;for(const e of t){if(void 0===i[e])return;"0"!==e&&!0===r&&(r=!1),r||(n+=e)}return e&&0===n.length&&(n="0"),n}function a(t){if(c(t,":")<2)return{host:t,isIPV6:!1};const e=function(t){let e=0;const n={error:!1,address:"",zone:""},i=[],r=[];let o=!1,a=!1,l=!1;function c(){if(r.length){if(!1===o){const t=s(r);if(void 0===t)return n.error=!0,!1;i.push(t)}r.length=0}return!0}for(let s=0;s<t.length;s++){const h=t[s];if("["!==h&&"]"!==h)if(":"!==h)if("%"===h){if(!c())break;o=!0}else r.push(h);else{if(!0===a&&(l=!0),!c())break;if(e++,i.push(":"),e>7){n.error=!0;break}s-1>=0&&":"===t[s-1]&&(a=!0)}}return r.length&&(o?n.zone=r.join(""):l?i.push(r.join("")):i.push(s(r))),n.address=i.join(""),n}(t);if(e.error)return{host:t,isIPV6:!1};{let t=e.address,n=e.address;return e.zone&&(t+="%"+e.zone,n+="%25"+e.zone),{host:t,escapedHost:n,isIPV6:!0}}}function l(t,e){let n="",i=!0;const r=t.length;for(let o=0;o<r;o++){const s=t[o];"0"===s&&i?(o+1<=r&&t[o+1]===e||o+1===r)&&(n+=s,i=!1):(i=s===e,n+=s)}return n}function c(t,e){let n=0;for(let i=0;i<t.length;i++)t[i]===e&&n++;return n}const h=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,p=/^\/?(?:.|\n)*?(?=\/|$)/u;t.exports={recomposeAuthority:function(t){const e=[];if(void 0!==t.userinfo&&(e.push(t.userinfo),e.push("@")),void 0!==t.host){let n=unescape(t.host);const i=o(n);if(i.isIPV4)n=i.host;else{const e=a(i.host);n=!0===e.isIPV6?`[${e.escapedHost}]`:t.host}e.push(n)}return"number"!=typeof t.port&&"string"!=typeof t.port||(e.push(":"),e.push(String(t.port))),e.length?e.join(""):void 0},normalizeComponentEncoding:function(t,e){const n=!0!==e?escape:unescape;return void 0!==t.scheme&&(t.scheme=n(t.scheme)),void 0!==t.userinfo&&(t.userinfo=n(t.userinfo)),void 0!==t.host&&(t.host=n(t.host)),void 0!==t.path&&(t.path=n(t.path)),void 0!==t.query&&(t.query=n(t.query)),void 0!==t.fragment&&(t.fragment=n(t.fragment)),t},removeDotSegments:function(t){const e=[];for(;t.length;)if(t.match(h))t=t.replace(h,"");else if(t.match(u))t=t.replace(u,"/");else if(t.match(d))t=t.replace(d,"/"),e.pop();else if("."===t||".."===t)t="";else{const n=t.match(p);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];t=t.slice(i.length),e.push(i)}}return e.join("")},normalizeIPv4:o,normalizeIPv6:a,stringArrayToHexStripped:s}},3837:t=>{"use strict";t.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:t=>{"use strict";t.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:t=>{"use strict";t.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},e={};function n(i){var r=e[i];if(void 0!==r)return r.exports;var o=e[i]={id:i,loaded:!1,exports:{}};return t[i].call(o.exports,o,o.exports,n),o.loaded=!0,o.exports}n.m=t,n.amdO={},n.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return n.d(e,{a:e}),e},n.d=(t,e)=>{for(var i in e)n.o(e,i)&&!n.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},n.u=t=>t+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),n.hmd=t=>((t=Object.create(t)).children||(t.children=[]),Object.defineProperty(t,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+t.id)}}),t),n.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),n.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;n.g.importScripts&&(t=n.g.location+"");var e=n.g.document;if(!t&&e&&(e.currentScript&&"SCRIPT"===e.currentScript.tagName.toUpperCase()&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var r=i.length-1;r>-1&&(!t||!/^http(s?):/.test(t));)t=i[r--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=t})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(6766);bio=i})();
 //# sourceMappingURL=package.js.map