@datagrok/bio 2.20.2 → 2.20.4

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Files changed (10) hide show
  1. package/CHANGELOG.md +4 -0
  2. package/dist/455.js +1 -1
  3. package/dist/455.js.map +1 -1
  4. package/dist/package-test.js +2 -2
  5. package/dist/package-test.js.map +1 -1
  6. package/dist/package.js +2 -2
  7. package/dist/package.js.map +1 -1
  8. package/package.json +3 -3
  9. package/test-console-output-1.log +330 -381
  10. package/test-record-1.mp4 +0 -0
package/dist/package.js CHANGED
@@ -1,8 +1,8 @@
1
- var bio;(()=>{var e={8924:(e,t,n)=>{"use strict";var i=n(7362);class r extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in r.aaSynonyms?r.aaSynonyms[e]:e;return super.get(t)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(e="grok"){switch(e){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",i="";for(const r of e)"("==r?t++:")"==r?t--:t?n+=r:i+=r;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[i,r]=this.getInnerOuter(e);if(i=i.length>6?`${i.slice(0,3)}...`:i,r=r.length>6?`${r.slice(0,3)}...`:r,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,r,1]:[this.undefinedColor,i,r,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,r,2]:[this.undefinedColor,i,r,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,r,3]:[this.undefinedColor,i,r,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,r,4]:[this.undefinedColor,i,r,4]}return[this.undefinedColor,i,r,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>r});var i=n(6082);async function r(){const e=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},3599:(e,t,n)=>{"use strict";n.d(t,{o:()=>i.o});var i=n(6869)},9124:(e,t,n)=>{"use strict";n.d(t,{b2:()=>o,fA:()=>s});var i=n(7389),r=n(6082);async function o(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}function s(e,t){if(!e)throw new Error("Argument 'a' of type Atom or HelmType is mandatory.");let n,i;const r=e;return"ATOM"===r.T?(n=r.biotype(),i=r.elem):(n=e,i=t),[n,i]}r.JsInputBase,Error,i.input.helmAsync=async function(e,t){return(await o()).createHelmInput(e,t)}},8438:(e,t,n)=>{"use strict";function i(e){return e.startsWith("[")&&e.endsWith("]")?e.slice(1,-1):e}n.d(t,{D:()=>i})},8123:(e,t,n)=>{"use strict";n.d(t,{u:()=>i});const i={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:{polymerType:"RNA",symbol:"d"},RIBOSE:{polymerType:"RNA",symbol:"r"},PHOSPHATE:{polymerType:"RNA",symbol:"p"},OXYGEN:"O",HYDROGEN:"H"}},4356:(e,t,n)=>{"use strict";n.d(t,{Eu:()=>a,ub:()=>s});var i=n(4328);const r="Libraries";let o=Promise.resolve();async function s(){let e;return o=o.then((async()=>{const t=i.userSettings.getValue(r,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await o,e}async function a(e){o=o.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),i.userSettings.add(r,"Settings",JSON.stringify(e),!0)})),await o}},5553:(e,t,n)=>{"use strict";n.d(t,{Qc:()=>A,WN:()=>S});var i=n(1991),r=n.n(i);const o="object"==typeof performance&&performance&&"function"==typeof performance.now?performance:Date,s=new Set,a="object"==typeof process&&process?process:{},l=(e,t,n,i)=>{"function"==typeof a.emitWarning?a.emitWarning(e,t,n,i):console.error(`[${n}] ${t}: ${e}`)};let c=globalThis.AbortController,h=globalThis.AbortSignal;if(void 0===c){h=class{onabort;_onabort=[];reason;aborted=!1;addEventListener(e,t){this._onabort.push(t)}},c=class{constructor(){t()}signal=new h;abort(e){if(!this.signal.aborted){this.signal.reason=e,this.signal.aborted=!0;for(const t of this.signal._onabort)t(e);this.signal.onabort?.(e)}}};let e="1"!==a.env?.LRU_CACHE_IGNORE_AC_WARNING;const t=()=>{e&&(e=!1,l("AbortController is not defined. If using lru-cache in node 14, load an AbortController polyfill from the `node-abort-controller` package. A minimal polyfill is provided for use by LRUCache.fetch(), but it should not be relied upon in other contexts (eg, passing it to other APIs that use AbortController/AbortSignal might have undesirable effects). You may disable this with LRU_CACHE_IGNORE_AC_WARNING=1 in the env.","NO_ABORT_CONTROLLER","ENOTSUP",t))}}Symbol("type");const u=e=>e&&e===Math.floor(e)&&e>0&&isFinite(e),d=e=>u(e)?e<=Math.pow(2,8)?Uint8Array:e<=Math.pow(2,16)?Uint16Array:e<=Math.pow(2,32)?Uint32Array:e<=Number.MAX_SAFE_INTEGER?p:null:null;class p extends Array{constructor(e){super(e),this.fill(0)}}class m{heap;length;static#e=!1;static create(e){const t=d(e);if(!t)return[];m.#e=!0;const n=new m(e,t);return m.#e=!1,n}constructor(e,t){if(!m.#e)throw new TypeError("instantiate Stack using Stack.create(n)");this.heap=new t(e),this.length=0}push(e){this.heap[this.length++]=e}pop(){return this.heap[--this.length]}}class 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o().count(0).take(t.length).map((e=>({position:e,symbol:t.getCanonical(e),biotype:v}))).toArray()})).toArray();for(let e=0;e<m;e++){const n=f[e],i=Math.floor(e*g),o=e===m-1?d:Math.floor((e+1)*g);y[e]=new Promise((e=>{n.onmessage=t=>{e(t.data)}})),n.postMessage({seqList:w,monomersDict:t,alphabet:r,polymerType:l,start:i,end:o})}const C=[],A=[];await Promise.all(y).then((e=>{for(const t of e)C.push(...t.molfiles),A.push(...t.warnings)})),setTimeout((()=>{f.forEach((e=>{e.terminate()}))}),0);const S=(0,s.qj)(p,e.name),x=i.Column.fromType(i.COLUMN_TYPE.STRING,S,e.length).init((e=>C[e]?.molfile));return x.semType=i.SEMTYPE.MOLECULE,x.meta.units=i.UNITS.Molecule.MOLBLOCK,x.setTag(".sequence-src-col",e.name),{molCol:x,warnings:A}}function c(e,t){const n={},r={};for(const o of e){const e=t.getWebEditorMonomer(o.biotype,o.symbol).backgroundcolor,a=(0,s.vG)(e??i.Color.toRgb(i.Color.mouseOverRows))??[1,0,0,.7];for(const e of o.atoms)n[e]=a;for(const e of 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Array(2).fill(0),branchPositionShift:new Array(2).fill(0),backboneAttachNode:0,branchAttachNode:0,flipFactor:1},C={sugar:b,phosphate:v,seqLength:e.length,atomCount:c,bondCount:u},A=new r.Cg,S=[];let x=0;for(w.i=0;w.i<C.seqLength;++w.i){const n=e[w.i];if(n.symbol===s._S)continue;const i=(0,r.xb)(t,{symbol:n.symbol,polymerType:(0,a.Y)(n.biotype)}),o=w.nodeShift,l=w.bondShift;y(i,p,g,w,C),i.stereoAtoms?.forEach((e=>S.push(e+x))),x+=i.atoms.x.length;const c=w.nodeShift-o,h=new Array(c);for(let e=0;e<c;++e)h[e]=o+e;const u=w.bondShift-l,d=new Array(u);for(let e=0;e<u;++e)d[e]=l+e;A.set(w.i,{biotype:n.biotype,symbol:n.symbol,atoms:h,bonds:d})}!function(e,t,n,r){const o=n.nodeShift+1;e[r.atomCount]=i.u.V3K_BEGIN_DATA_LINE+o+" "+i.u.OXYGEN+" "+f(n.backbonePositionShift[0])+" "+n.flipFactor*f(n.backbonePositionShift[1])+" 0.000000 0\n";const s=n.backboneAttachNode,a=o;t[r.bondCount]=i.u.V3K_BEGIN_DATA_LINE+n.bondShift+" 1 "+s+" "+a+"\n"}(p,g,w,C);const E=i.u.V3K_BEGIN_COUNTS_LINE+c+" 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m(e,t,n,o,l){if(t.semType!==r.SEMTYPE.MACROMOLECULE)return{molCol:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let h=t;const p=o.getSeqHandler(t);let m,g;p.notation!==a.Hi.SEPARATOR&&(h=p.convert(a.Hi.SEPARATOR,"."),h.name=t.name);try{g=o.getSeqHandler(h).alphabet,m=(0,d.pz)(g)}catch(e){const[t,n]=(0,u.AP)(e);return{molCol:null,warnings:[t]}}const y=function(e,t){const n=e.length,r=new Array(n),o=t.getSeqHandler(e);let a=!1;const l=o.defaultBiotype;for(let e=0;e<n;++e){const t=o.getSplitted(e);a||(a=0===t.length),r[e]=s().count(0).take(t.length).filter((e=>!t.isGap(e))).map((e=>({position:e,biotype:l,symbol:t.getCanonical(e)}))).toArray()}return a&&i.shell.warning(`Some values in the "${e.name}" column are empty`),r}(h,o),b=f(y,m,g,n,l),v=h.length,w=await(0,c.R)(h,b,g,m,n,o,l);return w.warnings.length>.05*v&&i.shell.warning(`Molfile conversion resulted in ${w.warnings.length} errors`),w}function f(e,t,n,i,r){const o=(0,l.Hb)(i,t,n),s={},c={value:null};if("RNA"===t){const e=n===a.YI.RNA?[p.u.RIBOSE,p.u.PHOSPHATE]:[p.u.DEOXYRIBOSE,p.u.PHOSPHATE];for(const n of e)g(s,n.symbol,o,r,t,c)}for(let n=0;n<e.length;++n){const i=e[n];for(const e of i){const n=e.symbol;if(""!==n)try{if("RNA"===t&&3===n.split(/\(|\)/).filter((e=>!!e)).length){const e=n.split(/\(|\)/)[1];g(s,e,o,r,t,c),s[t]?.[e]&&(s[t][n]=s[t][e])}else g(s,n,o,r,t,c)}catch(e){const t=e instanceof Error?e.message:e.toString(),i=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${n}', error:\n${t}\n${i}`),new Error(`Can't get monomer '${n}' from library: ${t}`)}}}return s}function g(e,t,n,i,r,o){const s={polymerType:r,symbol:t};if(!(0,h.bq)(e,s)){const a=function(e,t,n,i,r){if(t.has(e)){const s=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(s.rgroups),c=(o=s.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(e));)i.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(i[1]),parseInt(i[3]));return t}(o):function(e){const t=new Map;let n=e.indexOf(p.u.V2K_A_LINE,0),i=n;for(;-1!==n;){i=e.indexOf("\n",n);const r=parseInt(e.substring(n,i).replace(/^A\s+/,""));n=e.indexOf("R",i),i=e.indexOf("\n",n);const o=parseInt(e.substring(n,i).replace(/^R/,""));t.set(r,o),n=e.indexOf(p.u.V2K_A_LINE,i)}for(n=e.indexOf(p.u.V2K_RGP_LINE,0),i=e.indexOf("\n",n);-1!==n;){n+=p.u.V2K_RGP_SHIFT,i=e.indexOf("\n",n);const r=e.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<r.length;e+=2){if(t.has(r[e])&&t.get(r[e])!==r[e+1])throw new Error(`r-group index ${r[e]} has already been added with a different value`);t.set(r[e],r[e+1])}n=e.indexOf(p.u.V2K_RGP_LINE,i)}return t}(o),h=s.molfile.includes("V3000")?s.molfile:function(e,t){const n=t.get_mol(e),i=n.get_v3Kmolblock();return n.delete(),i}(function(e){let t=e.indexOf(p.u.V2K_A_LINE,0);-1===t&&(t=e.indexOf(p.u.V2K_RGP_LINE));const n=e.indexOf(p.u.V3K_END,t);return e.substring(0,t)+e.substring(n)}(s.molfile),n),u=function(e){let t=(e=e.replaceAll("\r","")).indexOf(p.u.V3K_BEGIN_COUNTS_LINE)+p.u.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const i=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:i,bondCount:parseInt(e.substring(t,n))}}(h),d=function(e,t){const n=new Array(t),i=new Float32Array(t),r=new Float32Array(t),o=new Array(t);let s=e.indexOf(p.u.V3K_BEGIN_ATOM_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;l++){s=e.indexOf(p.u.V3K_BEGIN_DATA_LINE,s)+p.u.V3K_IDX_SHIFT,a=e.indexOf(" ",s),s=a+1,a=e.indexOf(" ",s),n[l]=e.substring(s,a);const t=new Array(2);for(let n=0;n<2;++n)s=a+1,a=e.indexOf(" 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function(e,t,n){for(const[i,r]of n)e.atomTypes[i-1]=t[r-1]}(e,n,i),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const i of[1,2])if(e.get(t.rNodes[n])===i){const e=t.rNodes[i-1];t.rNodes[i-1]=t.rNodes[n],t.rNodes[n]=e}}(i,r),y(t,r),r}(d,m,a,c),g=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=e.indexOf(")",n);t=t.concat(e.substring(n,i).split(" ").slice(1).map((e=>parseInt(e)))),n=i,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(h),v={atoms:d,bonds:m,meta:f,stereoAtoms:g};return"PEPTIDE"===i?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;_(e,-i[t],-r[t]);const o=A(i[n],r[n]);S(e.atoms,-o),i[e.meta.rNodes[1]-1]<0&&x(e);const s=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const i=n[e],r=n[(e+1)%2];t.has(i)?t.get(i)?.push(r):t.set(i,new Array(1).fill(r))}return t}(e);let n=0;const i=e.atoms.atomTypes.length;let r=0;if(e.meta.terminalNodes.length<2)return null;for(;0===n;){const o=t.get(e.meta.terminalNodes[1])[r];if(e.atoms.atomTypes[o-1]===p.u.OXYGEN&&o!==e.meta.rNodes[1]&&(n=o),r++,r>i)return null}return n}(e);null!=s&&(function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){E(e,!0)}(e),S(e.atoms,-function(e,t){return A(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,s),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const i=t-1,r=n-1,o=e.atoms.x,s=e.atoms.y,a=o[i],l=s[i];o[i]=o[r],s[i]=s[r],o[r]=a,s[r]=l}(e,t,e.meta.rNodes[1])}(e,s))}(v):e===p.u.RIBOSE.symbol||e===p.u.DEOXYRIBOSE.symbol?function(e,t){const n=e.atoms.x,i=e.atoms.y;let r=e.meta.terminalNodes[0]-1;const o=e.meta.rNodes[1]-1;_(e,-n[r],-i[r]);const s=A(n[e.meta.rNodes[2]-1],i[e.meta.rNodes[2]-1]);S(e.atoms,-s),n[e.meta.rNodes[0]-1]>n[e.meta.rNodes[1]-1]&&x(e);const a=A(n[o],i[o]);S(e.atoms,3*Math.PI/2-a),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,i=e.meta.rNodes[2]-1,r=e.meta.terminalNodes[2]-1,o=t[i]-t[r],s=n[i]-n[r];return Math.atan2(o,s)}(e),r=e.meta.terminalNodes[0]-1,_(e,-n[r],-i[r])}(v,r):e===p.u.PHOSPHATE.symbol?function(e){const t=e.meta.rNodes[1]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;_(e,-i[t],-r[t]);const o=A(i[n],r[n]);S(e.atoms,Math.PI/2-o)}(v):function(e,t){const n=e.atoms.x,i=e.atoms.y,r=e.meta.terminalNodes[0]-1,o=e.meta.rNodes[0]-1;_(e,-n[r],-i[r]);const s=A(n[o],i[o]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");S(e.atoms,Math.PI-s+a);const c=function(e,t){return(0,l.YN)(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:i[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:i[e.meta.terminalNodes[0]-1]});if(1!=c)for(let e=0;e<n.length;++e)n[e]=(0,l.YN)(n[e]/c),i[e]=(0,l.YN)(i[e]/c)}(v,r),function(e,t,n){"PEPTIDE"===e?(b(t,e),w(t,t.meta.rNodes[1])):n===p.u.RIBOSE.symbol||n===p.u.DEOXYRIBOSE.symbol?(w(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],y(t.bonds,t.meta),b(t,e),w(t,t.meta.rNodes[1]),w(t,t.meta.rNodes[0]),w(t,t.meta.rNodes[2])):n===p.u.PHOSPHATE.symbol&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],_(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),b(t,e),w(t,t.meta.rNodes[1]))}(i,v,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===p.u.HYDROGEN&&(w(e,t+1),--t),++t}(v),function(e){const t=" RGROUPS=(1 1)";for(let n=0;n<(e.atoms.kwargs?.length??0);n++){const i=e.atoms.kwargs[n];i&&i.includes(t)&&(e.atoms.kwargs[n]=i.replace(t,""))}}(v),v}var o;return null}(t,n,i,r,o);if(!a)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);(0,h.LQ)(e,s,a)}}function y(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const i=t.terminalNodes,r=e.atomPairs;let o=0,s=0;for(;o<r.length&&s<i.length;){for(let e=0;e<i.length;++e)for(let t=0;t<2;++t)r[o][t]===n[e]&&(i[e]=r[o][(t+1)%2],n.length,++s);++o}}function b(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=v(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=v(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function v(e,t,n){return[(0,l.YN)(e.atoms.x[t]-e.atoms.x[n]),(0,l.YN)(e.atoms.y[t]-e.atoms.y[n])]}function w(e,t){if(void 0!==t){const n=t-1,i=e.atoms,r=e.bonds,o=e.meta;i.atomTypes.splice(n,1),i.x=C(Float32Array,i.x,n,1),i.y=C(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let e=0;e<o.terminalNodes.length;++e)o.terminalNodes[e]>t?--o.terminalNodes[e]:o.terminalNodes[e]===t&&(o.terminalNodes[e]=-1);for(let e=0;e<o.rNodes.length;++e)o.rNodes[e]>t?--o.rNodes[e]:o.rNodes[e]===t&&(o.rNodes[e]=-1);let s=0;for(;s<r.atomPairs.length;){const 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get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,o.pj)().then((e=>{e.awaitLoaded(1/0).then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const i of n){const n=t.getMonomer(e,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][e]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(r.e.colourPalette))}get(e,t){const n=c.palette.length,i=c.customMonomerColors[e],r=t??"PEPTIDE";if(i&&i[r])return i[r];const o=a.hashCode(e)%n;return s(c.palette[o])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(e,t,n)=>{"use strict";n.d(t,{BG:()=>s,sD:()=>l});var i=n(4328),r=n(1858),o=n(8070);function s(e){let 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this.errors=[],e}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(e,t,n)=>{"use strict";n.d(t,{s:()=>i});const i={true:"1",false:"0"}},6882:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>y,S$:()=>g,U0:()=>b});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553);const g="rgb(100,100,100)";class y extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,o){super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.sysMonomerLib=null,this.padding=5,this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol&&this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{const e=this.tableCol.dataFrame;this.gridCol.grid,-1===e.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})))}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,h.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=5;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.seqHelper.getSeqHandler(this.tableCol),n=this.props.separatorWidth+1*this.props.fontCharWidth,i=Math.ceil(this.colWidth/n),r=t.getSplitted(e),o=Math.min(i,r.length);let s=this._monomerLengthList[e];if(null===s||s.length<o){s=this._monomerLengthList[e]=new Array(r.length);let n=0;for(let e=0;e<o;++e){const i=r.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),a=(t.isSeparator()?this.separatorWidth:this.props.separatorWidth)+o.length*this.props.fontCharWidth;if(s[e]=a,n+=a,n>this.colWidth)break}}return s}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=Math.ceil(t/i),o=n.splitter(e),s=Math.min(r,o.length),a=new Array(s);let l=0;for(let e=0;e<s;++e){const i=o.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),s=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(a[e]=s,l+=s,l>t)break}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/r);for(let e=n;e<i;e++){if(this._processedRows.get(e)&&o<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,o),i=Math.min(o,n.length);i>t.length&&t.push(...new Array(i-t.length).fill(r));let s=0;for(let e=0;e<i;++e){const i=n.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),o=this.props.separatorWidth+r.length*this.props.fontCharWidth;if(t[e]=Math.max(t[e]??0,o),s+=o,s>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,o)}return t}getPosition(e,t,n){const[i,r]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:function(e,t){let n,i=100,r=0,o=e.length-1;for(;r<=o;){if(n=Math.floor((o+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?o=n-1:r=n+1,--i<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}render(e,t,n,i,r,o,a){const c=o.grid?.canvas===e.canvas;if(!this.seqHelper)return;const h=this.gridCol,m=this.tableCol,f=window.devicePixelRatio,y=`${this.toLog()}.render()`;this.logger.debug(`${y}, start`);let v=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));v=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const 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S=m.meta.units,x=m.getTag(l.gp.aligned),E=m.getTag(l.gp.separator)??"",_=this.props.separatorWidth+1*this.props.fontCharWidth,M=Math.ceil(i/_),I=m.temp["reference-sequence"],T=this.tableCol.temp["current-word"];T&&-1===m?.dataFrame?.currentRowIdx&&(this.tableCol.temp["current-word"]=null);const L=(()=>{const e=a.getSplitter(M)(null!=I&&""!=I?I:T??"");return s().count(0).take(e.length).map((t=>e.getOriginal(t))).toArray()})(),N=c?a.getSplitted(C):a.splitter(w);c||(y=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(w,i)));let $=d.yg.classic;x&&x.includes("MSA")&&S==l.Hi.SEPARATOR&&($=d.yg.MSA);const P=Math.min(N.length,M);for(let s=0;s<P;++s){const l=N.getOriginal(s),c=N.getCanonical(s);let h=g;const u=this.getMonomerLib();if(u){const e=a.defaultBiotype;h=u.getMonomerTextColor(e,c)}e.fillStyle=g;const p={color:h,pivot:0,left:!0,transparencyRate:1,separator:E,last:s===N.length-1,drawStyle:$,maxWord:y,wordIdx:s,gridCell:o,referenceSequence:L,maxLengthOfMonomer:v,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};if((0,d.oZ)(e,l,t+this.padding,n,i,r,p),A>i)break}}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n),this.errors.push(e)}finally{e.restore()}}onMouseMove(e,t){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==e.tableRowIndex)return;const r=e.bounds,o=t.offsetX-e.gridColumn.left+(e.gridColumn.left-r.x),s=this.getPosition(e.tableRowIndex,o,r.width);this.logger.debug(`${n}, start, argsX: ${o}, left: ${s}`);const a=this.seqHelper.getSeqHandler(this.tableCol),c=a.getSplitted(e.tableRowIndex);if(null!==s&&s<c.length){const n=a.alphabet??l.YI.UN,r={position:s,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:c.getCanonical(s)},o=[];let h=this._monomerStructureMap[r.symbol];{const e=this.getMonomerLib();h=this._monomerStructureMap[r.symbol]=e?e.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}o.push(h),i.tooltip.show(i.divV(o),t.x+16,t.y+16),(0,f.WN)(e,r)}else i.tooltip.hide(),(0,f.WN)(e,null)}}function b(e,t,n,i,r){return e?Math.max(Math.min(e.canvas.width/r-n,i)):Math.max(t.canvas.width/r-n,0)}},3856:(e,t,n)=>{"use strict";n.d(t,{Mn:()=>l,gp:()=>a,oZ:()=>u,yg:()=>c});var i=n(7278);const r="#808080",o="rgb(0,0,0)",s=i.zS;var a,l,c;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(a||(a={})),function(e){e.applyToBackground=".m.cellRenderer.applyToBackground"}(l||(l={})),function(e){e.MSA="MSA",e.classic="classic"}(c||(c={}));const h=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=c.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function u(e,t,n,i,a,l,u){var d,p,m;const f=Object.assign(Object.assign({},h),u);u.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let g=t.substring(0),y=f.last?"":f.separator;f.drawStyle===c.MSA&&(y="");let b=!0,v=!0,w="difference";if(null!=f.gridCell&&null!=f.gridCell.cell.column&&(b=f.gridCell.cell.column.temp["color-code"]??!0,v=f.gridCell.cell.column.temp["compare-with-current"]??!0,w=f.gridCell.cell.column.temp["highlight-difference"]??"difference"),f.referenceSequence){const e=f.referenceSequence[f.wordIdx];v&&f.referenceSequence.length>0&&"difference"===w&&(f.transparencyRate=g==e?.3:f.transparencyRate),v&&f.referenceSequence.length>0&&"equal"===w&&(f.transparencyRate=g!=e?.3:f.transparencyRate)}null!=f.maxLengthOfMonomer&&(g=s(g,f.maxLengthOfMonomer));const C=g+y;(d=f.monomerTextSizeMap)[C]??(d[C]=e.measureText(C));let A=f.monomerTextSizeMap[C];(p=f.monomerTextSizeMap)[g]??(p[g]=e.measureText(g));let S=f.monomerTextSizeMap[g].width;const x=l/2-(A.fontBoundingBoxAscent+A.fontBoundingBoxDescent)/2+1;(m=f.monomerTextSizeMap)[y]??(m[y]=e.measureText(y));const E=f.monomerTextSizeMap[y].width;function _(t,s){const a=b?f.color:o;e.fillStyle=a,e.globalAlpha=f.transparencyRate,f.drawStyle===c.classic&&(e.fillText(g,n+t,i+x),e.fillStyle=r,e.fillText(y,n+s,i+x)),f.drawStyle===c.MSA&&e.fillText(g,n+t,i+x)}A=A.width,f.drawStyle===c.MSA&&(S=f.maxWord[f.wordIdx],A=f.maxWord[f.wordIdx]);const M=(f.maxWord[f.wordIdx]??0)-(f.maxWord[0]??0);if(f.left||A>a)return _(M,M+S),n+M+S+E;{const e=(a-A)/2;return _(e,e+S),n+M+e+S}}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>l,Ec:()=>o,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>r});const i=["symbol","molfile","rgroups","name"],r="MonomerName",o={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(e,t,n)=>{"use strict";function i(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function r(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):void 0}function o(e){return[i(e),r(e)]}n.d(t,{AP:()=>o})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>o});var i=n(6082),r=n(439);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const i=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=i.Column.fromStrings("description",this.descriptionsArray),t=i.Column.fromStrings("sequence",this.sequencesArray);return t.semType=i.SEMTYPE.MACROMOLECULE,t.meta.units=r.Hi.FASTA,[i.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>h,dW:()=>c});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(7278),l=n(439);function c(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function h(e,t=s.Hi.SEPARATOR,n=s.YI.PT,r=(t===s.Hi.SEPARATOR?"-":void 0),c=void 0,h="seq",u=100,d=10**6){const p=n===s.YI.UN?c?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(n)),m=p.length,f=i.Column.fromType(i.COLUMN_TYPE.STRING,h,u);f.semType=i.SEMTYPE.MACROMOLECULE,f.meta.units=t,f.setTag(s.gp.alphabet,n),t==s.Hi.SEPARATOR&&f.setTag(s.gp.separator,r);const g=e.getSeqHandler(f);for(let e=0;e<u;e++){const n=o().count(0).take(d).map((e=>p[Math.floor(Math.random()*m)])).toArray(),i=g.joiner(new a.Mu(n,l.b9[t]));f.set(e,i)}return f}},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>r,_S:()=>u,b9:()=>d,gp:()=>o,q7:()=>h,z1:()=>a});var i,r,o,s=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm",e.CUSTOM="custom"}(i||(i={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(r||(r={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(o||(o={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},h=[new s.a(r.PT,c.fasta.peptide,.5),new s.a(r.DNA,c.fasta.dna,.55),new s.a(r.RNA,c.fasta.rna,.55)],u="",d={[i.FASTA]:"-",[i.SEPARATOR]:"",[i.HELM]:"*"}},2003:(e,t,n)=>{"use 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this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class d{get length(){return this.seqS.length}isGap(e){return this.getOriginal(e)===c.b9[c.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?c._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}const p=e=>{const t=o()(e.toString().matchAll(c.B5)).map((e=>e[2]??e[1])).toArray();return new u(t,c.b9[c.Hi.FASTA])},m=e=>e?new d(e):new u([],c.b9[c.Hi.FASTA]);function f(e,t=void 0){return n=>{if(n){let i;const r=new RegExp(`(?<=^|\\${e})("-"|'-'|[^\\${e}]*)(?=\\${e}|$)`,"g");return void 0!==t?(r.lastIndex=0,i=o()(n.matchAll(r)).take(t).map((e=>e[0])).toArray()):i=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t),new u(i,c.b9[c.Hi.SEPARATOR])}return new u([],c.b9[c.Hi.SEPARATOR])}}const g=e=>{const t=e.split("$")[0].split("|"),n=o()(t.map((e=>(e.match(/(?<=\{).+(?=})/)?.[0]?.split(".")??[]).map((e=>(0,h.D)(e)))))).flatten().toArray();return new u(n,c.b9[c.Hi.HELM])};function y(e,t,n=void 0){if(e.toLowerCase().startsWith(c.Hi.FASTA))return p;if(e.toLowerCase().startsWith(c.Hi.SEPARATOR))return f(t,n);if(e.toLowerCase().startsWith(c.Hi.HELM))return g;throw new Error(`Unexpected units ${e} .`)}const b=/([^\W_]+)/g;function v(e,t){if(e.length<=t)return e;const n=e.match(b),i=e.length>t||(n?.length??0)>1,r=n?.[0]??" 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n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},8312:(e,t,n)=>{"use strict";n.d(t,{Q:()=>r});var i=n(6082);async function r(){const e=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>r});var i=n(6082);function r(e,t){const n=e=>{const t=s.columns.addNewString((e+1).toString());return r.push(t),t},r=[],o=e.length,s=i.DataFrame.create(o),a=t.getSeqHandler(e);for(let e=0;e<o;++e){const t=a.getSplitted(e);for(let i=0;i<t.length;++i){const o=t.getCanonical(i);((r[i]??null)||n(i)).set(e,o,!1)}}return s}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>o});var i,r=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(i||(i={}));class 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e=0;e<i.length;++e)i[e]=(0,l.YN)(i[e]+t),void 0!==n&&(r[e]=(0,l.YN)(r[e]+n))}},294:(e,t,n)=>{"use strict";function i(e,t){return e[t.polymerType]?.[t.symbol]}function r(e,t){return!!e[t.polymerType]?.[t.symbol]}function o(e,t,n){let i=e[t.polymerType];i||(i=e[t.polymerType]={}),i[t.symbol]=n}n.d(t,{Cg:()=>s,LQ:()=>o,bq:()=>r,vF:()=>a,xb:()=>i});class s extends Map{constructor(e){super(e)}}class a{constructor(e,t){this.molfile=e,this.monomers=t}static createEmpty(){return new a("",new s(null))}}},330:(e,t,n)=>{"use strict";n.d(t,{kA:()=>r,pz:()=>s,qj:()=>o,vG:()=>a});var i=n(2003);function r(e,t){return e?e.columns.getUnusedName(t):t}function o(e,t){return r(e,`molfile(${t})`)}function s(e){let t;if(e===i.YI.PT||e===i.YI.UN)t="PEPTIDE";else{if(e!==i.YI.RNA&&e!==i.YI.DNA)throw new Error(`Unexpected alphabet '${e}'.`);t="RNA"}return t}function a(e){const t=7===e.length?/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e):/^#?([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})([a-f\d]{2})$/i.exec(e);return t?[parseInt(t[1],16)/256,parseInt(t[2],16)/256,parseInt(t[3],16)/256,t.length>4?parseInt(t[4],16)/256:.3]:null}},1093:(e,t,n)=>{"use strict";n(7362);class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>i});class i{static makePalette(e,t=!1,n=i){const r={};return e.forEach((e=>{const n=e[0],i=e[1];n.forEach(((e,n)=>{r[e]=this.colourPalette[i][t?0:n]}))})),new n(r)}constructor(e){this._palette=e}get(e,t){return this._palette[e]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4574:(e,t,n)=>{"use strict";n.d(t,{O:()=>o,n:()=>r});var i=n(1858);class r{constructor(e,t=!0,n){return this.substructure=e,this.readOnly=t,this.logger=n,new Proxy(this,{set:(e,t,n)=>{if(this.logger?.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{constructor(){this.onChanged=new i.Subject,this._props=null,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&"logger"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},4152:(e,t,n)=>{"use strict";var i=n(6082),r=n(7362),o=n(6718);function s(e,t=!0){if(null==e)return"rgb(100,100,100)";const n=i.Color.fromHtml(e);if(t){const e=i.Color.g(n),t=i.Color.r(n),r=i.Color.b(n),o=Math.sqrt(Math.pow(0-t,2)+Math.pow(0-e,2)+Math.pow(0-r,2));if(o>210)return`rgb(${t/o*210},${e/o*210},${r/o*210})`}return i.Color.toRgb(n)}class a{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class l{}class c extends l{static get palette(){return c._pallete||(c._pallete=c.buildPalette()),c._pallete}static buildPalette(){return(0,o.pj)().then((e=>{e.awaitLoaded(1/0).then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{c.customMonomerColors={},c.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const i of n){const n=t.getMonomer(e,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][e]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(r.e.colourPalette))}get(e,t){const n=c.palette.length,i=c.customMonomerColors[e],r=t??"PEPTIDE";if(i&&i[r])return i[r];const o=a.hashCode(e)%n;return s(c.palette[o])}}c._pallete=null,c.customMonomerColors={},c.polymerTypes=[]},6642:(e,t,n)=>{"use strict";n.d(t,{BG:()=>s,sD:()=>l});var i=n(4328),r=n(1858),o=n(8070);function s(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const i=e.cell.column;if(t=t??(i?i.temp:null),!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,t]}class a{onKeyDown(e,t){}onKeyPress(e,t){}onMouseEnter(e,t){}onMouseLeave(e,t){}onMouseDown(e,t){}onMouseUp(e,t){}onMouseMove(e,t){}onClick(e,t){}onDoubleClick(e,t){}}class l extends a{constructor(e,t,n){super(),this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++l.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.tableCol&&this.tableCol.dataFrame&&(this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.subs.push(this.tableCol.dataFrame.onColumnsRemoved.subscribe((e=>{try{this.destroyed||!this.tableCol||this.tableCol.dataFrame||this.destroy()}catch(e){this.logger.error(e)}})))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,o.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}l.viewerCounter=-1},673:(e,t,n)=>{"use strict";n.d(t,{s:()=>i});const i={true:"1",false:"0"}},6882:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>y,S$:()=>g,U0:()=>b});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(8312),l=n(2003),c=n(6642),h=n(6718),u=n(9192),d=n(3856),p=n(673),m=n(3599),f=n(5553);const g="rgb(100,100,100)";class y extends c.sD{get separatorWidth(){return this.props?.fontCharWidth?this.props?.fontCharWidth:5}constructor(e,t,n,i,o){super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.sysMonomerLib=null,this.padding=5,this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),this.tableCol&&this.gridCol&&this.subs.push(this.tableCol.dataFrame.onCurrentRowChanged.subscribe((()=>{const e=this.tableCol.dataFrame;this.gridCol.grid,-1===e.currentRowIdx&&(this.tableCol.temp["reference-sequence"]=null,this.tableCol.temp["current-word"]=null,this.invalidateGrid())})))}async init(){await Promise.all([(async()=>{this.seqHelper=await(0,a.Q)(),this.invalidateGrid()})(),(async()=>{const e=await(0,h.pj)();this.sysMonomerLib=e.getMonomerLib()})()]),this.subs.push(this.sysMonomerLib.onChanged.subscribe((()=>{this.reset()}))),this.reset()}static getFontSettings(e){let t=12;return e&&e.temp[".mm.cellRenderer.fontSize"]&&"number"==typeof e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(t=Math.max(e.temp[".mm.cellRenderer.fontSize"],1)),{font:`${t}px monospace`,fontWidth:.6*t}}toLog(){return`MonomerPlacer<${this.viewerId}>`}getMonomerLib(){return this.tableCol.temp[".mm.cellRenderer.overriddenLibrary"]??this.sysMonomerLib}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset(),this.invalidateGrid()}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}getCellMonomerLengths(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol);if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n)}const i=n.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e);return[i,this.getSummedMonomerLengths(i)]}getSummedMonomerLengths(e){const t=new Array(e.length+1);t[0]=5;for(let n=1;n<t.length;n++)t[n]=t[n-1]+e[n-1];let n=t[0];for(let e=1;e<t.length;e++)t[e]?n=t[e]:t[e]=n;return t}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.seqHelper.getSeqHandler(this.tableCol),n=this.props.separatorWidth+1*this.props.fontCharWidth,i=Math.ceil(this.colWidth/n),r=t.getSplitted(e),o=Math.min(i,r.length);let s=this._monomerLengthList[e];if(null===s||s.length<o){s=this._monomerLengthList[e]=new Array(r.length);let n=0;for(let e=0;e<o;++e){const i=r.getOriginal(e),o=this.props.monomerToShort(i,this.monomerLengthLimit),a=(t.isSeparator()?this.separatorWidth:this.props.separatorWidth)+o.length*this.props.fontCharWidth;if(s[e]=a,n+=a,n>this.colWidth)break}}return s}getCellMonomerLengthsForSeqValue(e,t){const n=this.seqHelper.getSeqHandler(this.tableCol),i=this.props.separatorWidth+1*this.props.fontCharWidth,r=Math.ceil(t/i),o=n.splitter(e),s=Math.min(r,o.length),a=new Array(s);let l=0;for(let e=0;e<s;++e){const i=o.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),s=(n.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.fontCharWidth;if(a[e]=s,l+=s,l>t)break}return a}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.fontCharWidth,o=Math.ceil(this.colWidth/r);for(let e=n;e<i;e++){if(this._processedRows.get(e)&&o<=this._processedMaxVisibleSeqLength)continue;const n=this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e,o),i=Math.min(o,n.length);i>t.length&&t.push(...new Array(i-t.length).fill(r));let s=0;for(let e=0;e<i;++e){const i=n.getOriginal(e),r=this.props.monomerToShort(i,this.monomerLengthLimit),o=this.props.separatorWidth+r.length*this.props.fontCharWidth;if(t[e]=Math.max(t[e]??0,o),s+=o,s>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,o)}return t}getPosition(e,t,n){const[i,r]=this.getCellMonomerLengths(e,n);return 0===this.seqHelper.getSeqHandler(this.tableCol).getSplitted(e).length?null:function(e,t){let n,i=100,r=0,o=e.length-1;for(;r<=o;){if(n=Math.floor((o+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?o=n-1:r=n+1,--i<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit!=e&&(this.monomerLengthLimit=e,this.dirty=!0)}setSeparatorWidth(e){this.separatorWidth!=e&&(this.props.separatorWidth=e,this.dirty=!0)}render(e,t,n,i,r,o,a){const c=o.grid?.canvas===e.canvas;if(!this.seqHelper)return;const h=this.gridCol,m=this.tableCol,f=window.devicePixelRatio,y=`${this.toLog()}.render()`;this.logger.debug(`${y}, start`);let v=this.monomerLengthLimit;if(d.gp.maxMonomerLength in m.tags){const e=parseInt(m.getTag(d.gp.maxMonomerLength));v=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in m.temp){const e=m.temp[".mm.cellRenderer.maxMonomerLength"];v=!isNaN(e)&&e?e:50}e.save();try{const a=this.seqHelper.getSeqHandler(m);if(m.temp[".mm.cellRenderer.settingsChanged"]===p.s.true||this.monomerLengthLimit!=v){let e=0;const t=8;e=m.temp[".mm.cellRenderer.gapLength"]??e,this.setMonomerLengthLimit(v),this.setSeparatorWidth(a.isMsa()?t:e),m.temp[".mm.cellRenderer.settingsChanged"]=p.s.false}let[u,y]=this.getCellMonomerLengths(o.tableRowIndex,i);u.length;const w=o.cell.value,C=o.cell.rowIndex,A=(m.getTag(l.gp.alphabet),50);c&&(i=b(h?.grid,e,t,i,f)),e.beginPath(),e.rect(t+this.padding,n+this.padding,i-this.padding-1,r-2*this.padding),e.clip(),e.font=this.props?.font??"12px monospace",e.textBaseline="top";const S=m.meta.units,x=m.getTag(l.gp.aligned),E=m.getTag(l.gp.separator)??"",_=this.props.separatorWidth+1*this.props.fontCharWidth,M=Math.ceil(i/_),I=m.temp["reference-sequence"],T=this.tableCol.temp["current-word"];T&&-1===m?.dataFrame?.currentRowIdx&&(this.tableCol.temp["current-word"]=null);const L=(()=>{const e=a.getSplitter(M)(null!=I&&""!=I?I:T??"");return s().count(0).take(e.length).map((t=>e.getOriginal(t))).toArray()})(),N=c?a.getSplitted(C):a.splitter(w);c||(y=this.getSummedMonomerLengths(this.getCellMonomerLengthsForSeqValue(w,i)));let $=d.yg.classic;x&&x.includes("MSA")&&S==l.Hi.SEPARATOR&&($=d.yg.MSA);const P=Math.min(N.length,M);for(let s=0;s<P;++s){const l=N.getOriginal(s),c=N.getCanonical(s);let h=g;const u=this.getMonomerLib();if(u){const e=a.defaultBiotype;h=u.getMonomerTextColor(e,c)}e.fillStyle=g;const p={color:h,pivot:0,left:!0,transparencyRate:1,separator:E,last:s===N.length-1,drawStyle:$,maxWord:y,wordIdx:s,gridCell:o,referenceSequence:L,maxLengthOfMonomer:v,monomerTextSizeMap:this._monomerLengthMap,logger:this.logger};if((0,d.oZ)(e,l,t+this.padding,n,i,r,p),A>i)break}}catch(e){const[t,n]=(0,u.AP)(e);this.logger.error(t,void 0,n),this.errors.push(e)}finally{e.restore()}}onMouseMove(e,t){const n=`${this.toLog()}.onMouseMove()`;if(!this.seqHelper||null==e.tableRowIndex)return;const r=e.bounds,o=t.offsetX-e.gridColumn.left+(e.gridColumn.left-r.x),s=this.getPosition(e.tableRowIndex,o,r.width);this.logger.debug(`${n}, start, argsX: ${o}, left: ${s}`);const a=this.seqHelper.getSeqHandler(this.tableCol),c=a.getSplitted(e.tableRowIndex);if(null!==s&&s<c.length){const n=a.alphabet??l.YI.UN,r={position:s,biotype:n===l.YI.RNA||n===l.YI.DNA?m.o.NUCLEOTIDE:m.o.AA,symbol:c.getCanonical(s)},o=[];let h=this._monomerStructureMap[r.symbol];{const e=this.getMonomerLib();h=this._monomerStructureMap[r.symbol]=e?e.getTooltip(r.biotype,r.symbol):i.divText("Monomer library is not available")}o.push(h),i.tooltip.show(i.divV(o),t.x+16,t.y+16),(0,f.WN)(e,r)}else i.tooltip.hide(),(0,f.WN)(e,null)}}function b(e,t,n,i,r){return e?Math.max(Math.min(e.canvas.width/r-n,i)):Math.max(t.canvas.width/r-n,0)}},3856:(e,t,n)=>{"use strict";n.d(t,{Mn:()=>l,gp:()=>a,oZ:()=>u,yg:()=>c});var i=n(7278);const r="#808080",o="rgb(0,0,0)",s=i.zS;var 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i.if(t,(()=>this.mergeEvaluated(e,h.Name))),!0}}function M(e,t,n,i){const r=new _(e,n,t);"code"in n?n.code(r,i):r.$data&&n.validate?(0,l.funcKeywordCode)(r,n):"macro"in n?(0,l.macroKeywordCode)(r,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(r,n)}t.KeywordCxt=_;const I=/^\/(?:[^~]|~0|~1)*$/,T=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function L(e,{dataLevel:t,dataNames:n,dataPathArr:i}){let r,o;if(""===e)return u.default.rootData;if("/"===e[0]){if(!I.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);r=e,o=u.default.rootData}else{const s=T.exec(e);if(!s)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+s[1];if(r=s[2],"#"===r){if(a>=t)throw new Error(l("property/index",a));return i[t-a]}if(a>t)throw new Error(l("data",a));if(o=n[t-a],!r)return o}let s=o;const a=r.split("/");for(const e of a)e&&(o=h._`${o}${(0,h.getProperty)((0,p.unescapeJsonPointer)(e))}`,s=h._`${s} && ${o}`);return s;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is 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n;const{gen:c,keyword:h,schema:u,parentSchema:d,$data:p,it:m}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(m,t);const f=!p&&t.compile?t.compile.call(m.self,u,d,m):t.validate,g=l(c,h,f),y=c.let("valid");function b(n=(t.async?i._`await `:i.nil)){const s=m.opts.passContext?r.default.this:r.default.self,a=!("compile"in t&&!p||!1===t.schema);c.assign(y,i._`${n}${(0,o.callValidateCode)(e,g,s,a)}`,t.modifying)}function v(e){var n;c.if((0,i.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)b(),t.modifying&&a(e),v((()=>e.error()));else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try((()=>b(i._`await `)),(t=>c.assign(y,!1).if(i._`${t} instanceof ${m.ValidationError}`,(()=>c.assign(e,i._`${t}.errors`)),(()=>c.throw(t))))),e}():function(){const e=i._`${g}.errors`;return c.assign(e,null),b(i.nil),e}();t.modifying&&a(e),v((()=>function(e,t){const{gen:n}=e;n.if(i._`Array.isArray(${t})`,(()=>{n.assign(r.default.vErrors,i._`${r.default.vErrors} === null ? ${t} : ${r.default.vErrors}.concat(${t})`).assign(r.default.errors,i._`${r.default.vErrors}.length`),(0,s.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:i},r,o){if(Array.isArray(r.keyword)?!r.keyword.includes(o):r.keyword!==o)throw new Error("ajv implementation error");const s=r.dependencies;if(null==s?void 0:s.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${o}: ${s.join(",")}`);if(r.validateSchema&&!r.validateSchema(e[o])){const e=`keyword "${o}" value is 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0!==i&&(e.compositeRule=i),void 0!==r&&(e.createErrors=r),void 0!==o&&(e.allErrors=o),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var r=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return r.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return r.CodeGen}});const o=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),h=n(6939),u=n(208),d=n(4227),p=n(3837),m=n(5944),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as 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console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const i=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,e,"NOT SUPPORTED"),A.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=M.call(this),e.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),x.call(this),e.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let i=p;"id"===n&&(i={...p},i.id=i.$id,delete i.$id),t&&e&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const i=n(t);return"$async"in 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t;for(;"string"==typeof(t=S.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,i,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=S.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,h.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof 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n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var r,o,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var h=o,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,o.undirected),e&&l)return u}}function le(e,t,n,i,r,o){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,r.in,o),e&&s))return s;if("in"!==i&&(s=a(e,r.out,o,i?void 0:r.key),e&&s))return s}if("directed"!==n&&(s=a(e,r.undirected,o),e&&s))return s}function ce(e,t,n,i,r,o,s){var a,l=n?oe:re;if("undirected"!==t){if(void 0!==r.in&&"out"!==i&&(a=l(e,r.in,o,s),e&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(e,r.out,o,s),e&&a))return a}if("directed"!==t&&void 0!==r.undirected&&(a=l(e,r.undirected,o,s),e&&a))return a}var he=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ue(){this.A=null,this.B=null}function de(e,t,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var h=r(c.key,c.attributes);if(e&&h)return c.key}}}function pe(e,t,n,i,r){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,r);if("string"==typeof n)return de(e,null,i,i[n],r)}var o,s=new ue;if("undirected"!==t){if("out"!==n){if(o=de(e,null,i,i.in,r),e&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=de(e,s,i,i.out,r),e&&o)return o;s.wrap(i.out)}}if("directed"!==t&&(o=de(e,s,i,i.undirected,r),e&&o))return o}function me(e,t,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return e&&e.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function fe(e,t,n,i,r){for(var o,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=r(s.key,null,s.attributes,null,null,null,null),e&&u))return null}}function ge(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ue.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},ue.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,r,o,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(o),h=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(o,'" not found.'));if(!h)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,r,l,h,a);e._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,u.key=r,e.emit("edgeAdded",u),r}function Ee(e,t,n,i,r,o,s,l,h){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(o=""+o,s=""+s,h&&(u=l,l=void 0),!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(o),f=e._nodes.get(s);if(!n&&(d=e._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Se(e,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=Se(e,s,{}),w=!0),d=new z(i,r,m,f,l),e._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=r,e.emit("edgeAdded",b),[r,!0,v,w]}function _e(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,r=t.attributes,o=t.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),o?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:r,source:n.key,target:i.key,undirected:o})}var Me=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?U:"directed"===e.type?W:q;u(s(t),"NodeDataClass",i);var r="geid_"+ve()+"_",o=0;return u(s(t),"_attributes",{}),u(s(t),"_nodes",new Map),u(s(t),"_edges",new Map),u(s(t),"_directedSize",0),u(s(t),"_undirectedSize",0),u(s(t),"_directedSelfLoopCount",0),u(s(t),"_undirectedSelfLoopCount",0),u(s(t),"_edgeKeyGenerator",(function(){var e;do{e=r+o++}while(t._edges.has(e));return e})),u(s(t),"_options",e),Ce.forEach((function(e){return u(s(t),e,t[e])})),d(s(t),"order",(function(){return t._nodes.size})),d(s(t),"size",(function(){return t._edges.size})),d(s(t),"directedSize",(function(){return t._directedSize})),d(s(t),"undirectedSize",(function(){return t._undirectedSize})),d(s(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(s(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(s(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",(function(){return"graphology"})),t}t(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(e){return this._nodes.has(""+e)},r.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},r.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},r.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},r.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},r.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},r.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},r.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},r.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},r.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},r.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},r.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},r.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},r.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},r.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},r.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},r.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},r.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},r.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},r.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},r.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},r.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},r.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},r.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(e===i)return r;if(e===r)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},r.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},r.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},r.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},r.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},r.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},r.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var r=t?t({}):{};return n=new this.NodeDataClass(e,r),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:r}),[e,!0]},r.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{_e(this,t),t=t.next}while(t)}for(var r in n.in){t=n.in[r];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},r.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},r.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(e){return this._attributes[e]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},r.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},r.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},r.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},r.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=e(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},r.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},r.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},r.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},r.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},r.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(t=i.next()).done;)n=t.value,r[o++]=e(n.key,n.attributes);return r},r.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},r.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},r.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),r=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=t,o=this._nodes.values();!0!==(n=o.next()).done;)r=e(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return h(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,r){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,r,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},r.import=function(e){var t,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new D("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new D("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(r=e.nodes,!Array.isArray(r))throw new D("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=r.length;t<n;t++){ge(o=r[t]);var h=o,u=h.key,d=h.attributes;l?this.mergeNode(u,d):this.addNode(u,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),r=e.edges,!Array.isArray(r))throw new D("Graph.import: invalid edges. 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i=t[n],r="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(r.root),i.disable?(r.enabled=!1,s.tooltip.bind(r.input??r.root,i.disableTooltip??"")):s.tooltip.bind(r.input??r.root,i.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let r=2;r<t.inputs.length;r++){const o=t.inputs[r];(this.preprocessingFunctionSettings[o.name]||n.inputParams[t.inputs[r].name].value||o.defaultValue)&&(this.preprocessingFunctionSettings[o.name]=this.preprocessingFunctionSettings[o.name]??n.inputParams[o.name].value??o.defaultValue);const s=i.find((e=>e.property.name===o.name));s&&(null!==this.preprocessingFunctionSettings[o.name]&&void 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dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}const R=rxjs.operators;var O=n(6295);const k=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,i)}class F{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||o.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(u.set(o,i),s<m&&(m=s),a>f&&(f=a),e())}}))}await Promise.all(l),n&&u.forEach(((e,t)=>{u[t]=(e-m)/(f-m)})),i(u)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class H{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),r=e.distance.length,o=e.distance;for(let e=0;e<r;e++)i[Math.floor(o[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<r;e++)o[e]<m&&(l[p]=u[e],c[p]=d[e],h[p]=o[e],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(e,t,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,o,s,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),o.forEach(((e,t)=>o[t].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:u,endIdx:p,threshold:r,fnNames:t,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:o}})=>{e?(d[n].terminate(),h(e)):(d[n].terminate(),i({i:t,j:r,distance:o,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,r=.8,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,threshold:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,r,o=15,s,a,l=i.EUCLIDEAN){if(e.length!==r.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=e[0].length,d=e.map((e=>e[t])),p=Math.ceil(u/this._workerCount);for(let t=0;t<this._workerCount;t++)h[t]=new Promise(((n,i)=>{const h=t*p,m=t===this._workerCount-1?u:(t+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map((e=>e.slice(h,m))),target:d,fnNames:r,opts:s,nNeighbours:o,weights:a,aggregationMethod:l,startIdx:h}),c[t].onmessage=({data:{error:e,knnDistances:r,knnIndexes:o}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:r,knnIndexes:o}))}}));const m=await Promise.all(h),f={knnDistances:new Array(o).fill(99999),knnIndexes:new Array(o).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(f.knnDistances,f.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return f}async multiColumnKNN(e,t,r=15,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:h,fnNames:t,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}}));const d=await Promise.all(u),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of d)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,o=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=i&&(r.push(l),o.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,D,V=n(8774);(D=B||(B={})).none="none",D.bold="bold",D.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,r,o,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(r=this.lines.colors)||void 0===r?void 0:r[e])?null===(o=this.lines.colors)||void 0===o?void 0:o[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[e])?null===(u=this.lines.widths)||void 0===u?void 0:u[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const r=this.getPointOnDistance(w,C,S,x,i,t),o=this.getPointOnDistance(S,x,w,C,n,t);w=r.x,C=r.y,S=o.x,x=o.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,r=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:w,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:C,n,r)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case B.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,r=null;const o=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(o.get(this.lines.from[s])&&o.get(this.lines.to[s])&&this.visibility.getBit(s)){const o=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,o,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);r=this.calculateDistToCurveLine(s,e,t,i,h,u)}else r=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=r-2&&e<=o+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const r=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,h=c-l;return this.calculateDistToCurveInRect(t,n,i,o,r,e,h)}return null}calculateDistToCurveInRect(e,t,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!d||d>g)&&(d=g),u[o]=Math.max(m,f),c[o]=a,h[o]=p}for(let e=0;e<c.length;e++)u[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,h[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,r,o){const s=n-r*((n-e)/o),l=i-r*((i-t)/o);return new a.Point(s,l)}findControlPoint(e,t,n,i,r,o){const s=t+(i-t)/2,l=n+(r-n)/2;let c=s-t,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(e,t,n,i,r){const o=Math.atan2(i-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}var U,W,q=n(8060),z=n(3629);async function Y(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(q.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),e?h(e):c(t),setTimeout((()=>u.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,r,s,a,l);return c=c.map((e=>(0,z.S8)(e))),c}(W=U||(U={})).EUCLIDEAN="EUCLIDEAN",W.MANHATTAN="MANHATTAN";const K={[U.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[U.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.VECTOR_COSINE="Vector Cosine",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[Z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[Z.VECTOR_COSINE]:function(e,t){return`\n var dist: f32 = 0.0;\n var productSum: f32 = 0.0;\n var aSquareSum: f32 = 0.0;\n var bSquareSum: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n productSum = productSum + f32(a[i] * b[i]);\n aSquareSum = aSquareSum + f32(a[i] * a[i]);\n bSquareSum = bSquareSum + f32(b[i] * b[i]);\n }\n var sim = productSum / (sqrt(aSquareSum) * sqrt(bSquareSum));\n return (1.0 - sim) / 2.0;\n `},[Z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},Q={[Z.HAMMING]:e=>Math.ceil(e/30),[Z.EUCLIDEAN]:e=>Math.ceil(e/30),[Z.MANHATTAN]:e=>Math.ceil(e/30),[Z.TANIMOTO]:e=>Math.ceil(e/30),[Z.SOKAL]:e=>Math.ceil(e/30),[Z.COSINE]:e=>Math.ceil(e/30),[Z.ASYMMETRIC]:e=>Math.ceil(e/30),[Z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[Z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[Z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[Z.Difference]:e=>1,[Z.OneHot]:e=>Math.ceil(e/40),[Z.VECTOR_COSINE]:e=>Math.ceil(e/30)},ee={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.VECTOR_COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference,Z.VECTOR_COSINE]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference,Z.VECTOR_COSINE]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var te=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function ne(e,t,n,i){return e.map(((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${J[e](t[i],i)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${K[i](e.length)}\n }\n \n `}var ie=n(1991),re=n.n(ie);let oe=0;const se="cliffsDf",ae=new h.Subject,le="Δ activity",ce="SALI",he="Similarity",ue="line index",de=["From","To"],pe="filterCliffs";async function me(e,t,i,r,l,c,h,u,d,p,m,f,g,y,b,v,w){oe++;const C=c/100;let A,S=!1;const x=f.inputs,I=await f.apply({[x[0].name]:t,[x[1].name]:h,...d.preprocessingFuncArgs??{}});let T=[];if(u===N){const t=await function(e,t,i,r,o,s,a=10,l=!1,c=2){const h=new Worker(new URL(n.p+n.u(980),n.b));let u;return h.postMessage({data:e,threshold:t,weights:i,aggregationMethod:r,distanceFns:o,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{u=e,h.onmessage=t=>{setTimeout((()=>h.terminate()),100),e(t.data.res)},h.onerror=e=>{setTimeout((()=>h.terminate()),100),t(e)}})),terminate:()=>{try{u(null),h.terminate()}catch(e){console.error(e)}}}}([I.entries],c,[1],"MANHATTAN",[h],[I.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),T=[t.embedX,t.embedY]}else T=await Y([I.entries],u,[h],[1],"MANHATTAN",{...d,distanceFnArgs:[I.options??{}]});if(T.length!==i.length)throw new 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Float32Array([i.range]),m=`\n range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,o[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=u.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((e,t)=>{f.set(e.arraySizes,t*h)}));const g=1e4,y=100,b=u.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${h}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${h}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${ne(n,u.map((e=>e.maxEntryLen)),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),$=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=h-2-Math.floor(Math.sqrt(-8*t+4*h*(h-1)-7)/2-.5),i=t-h*n+Math.floor((n+1)*(n+2)/2);T[e]=O,L[e]=R,N[e]=i,$[e]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce(((e,t)=>e+t.sourceArraySize),0),G=u.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,H=k*Uint32Array.BYTES_PER_ELEMENT;let B=H;const D=15&H;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,g).set(T),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(L),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(N),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set($),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,f.length).set(f),W+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,W,c).set(r),W+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of u){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,W,n).set(e.flatSourceArray),W+=n*t.BYTES_PER_ELEMENT}V.unmap();const q=G*Uint32Array.BYTES_PER_ELEMENT;let z=q;const Y=15&q;0!==Y&&(z+=16-Y),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const e of u)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(X,J,e.suppInfoBuffer.length).set(e.suppInfoBuffer),J+=e.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const te=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=te;const re=15&te;0!==re&&(ie+=16-re);const oe=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:oe}}]}),ae=s.createBuffer({label:"results out buffer",size:oe.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],he=[];let ue=!1;for(;!ue;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(oe,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let r=0;const o=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new 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t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}($.saliVals),G=.8/(k.max-k.min),F=o.shell.getTableView(e.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:P.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(e,t,n,i,r,o,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return de.forEach(((e,t)=>{h.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(h.col(e),o),h.col(e).semType=r})),h.columns.addNewFloat(le).init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),h.columns.addNewInt(ue).init((e=>e)),h.columns.addNewFloat(ce).init((e=>t.saliVals[e])),h.columns.addNewFloat(he).init((e=>t.simVals[e])),h.name=`${se}${oe}`,{lines:c,linesDf:h}}(e,$,t,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ce).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const W=new j(D,i[0],i[1],V.lines,B.none),q=b?b(V.linesDf,de).sort([ce],[!1]):V.linesDf.plot.grid().sort([ce],[!1]);q.col(ue)&&(q.col(ue).visible=!1),e.temp[".cliffsDfGrid"]=q;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{const e=re()(F.viewers).some((e=>e.dataFrame.name===`${se}${oe}`));w&&!e&&F.addViewer(q),F.dockManager.dock(q,"down",null,"Activity cliffs",v??.2)}));z.classList.add("scatter_plot_link","cliffs_grid");const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(D.dataFrame.setTag(pe,i[0]),e.filter.and(O),ae.next(i[0])):(D.dataFrame.setTag(pe,""),e.filter.setAll(!0),ae.next(""))}});D.root.prepend(s.divH([z,K.root],"cliffs_div")),ae.subscribe((e=>{K.enabled=""===e||e===i[0]}));let X=!1;D.onEvent("d4-before-draw-scene").subscribe((t=>{X?X=!1:K.value&&(setTimeout((()=>{e.filter.and(O)}),100),X=!0)}));const J=o.events.onViewerClosed.subscribe((e=>{e.args.viewer===D&&(F.dockManager.close(q.root),J.unsubscribe(),F.subs=F.subs.filter((e=>e!==J)))}));return F.subs.push(J),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<V.linesDf.rowCount;e++)V.lines.widths[e]=e===V.linesDf.currentRowIdx?3:1;W.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===de[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;W.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(e,t,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=e/s,c=t/a,h=Math.min(l,c),u=e/h*5,d=t/h*5,p=(n<r?n:r)+s/2-u/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],V.lines.from[n]),D.dataFrame.get(i[1],V.lines.from[n]),D.dataFrame.get(i[0],V.lines.to[n]),D.dataFrame.get(i[1],V.lines.to[n]));D.zoom(a,h,c,u),K.value?e.filter.and(O):!0===K.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,r,a,l,c,h){const u=t.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{o.shell.o=t.root}),500)}(e,A,V.lines.from[r],V.lines.to[r],r,t,l,V.linesDf.get(ce,r),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(t.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<V.linesDf.rowCount;e++){const n=V.linesDf.selection.get(e);n&&(t.set(V.lines.from[e],!0),t.set(V.lines.to[e],!0)),V.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),W.linesToRender=V.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<V.lines.colors.length;e++)V.lines.colors[e]="0,128,0";W.linesToRender=V.lines})(q.dataFrame))})),W.lineClicked.subscribe((t=>{if(S=!0,W.currentLineId=t.id,-1!==t.id){const n=V.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==t.id&&(V.linesDf.currentRowIdx=t.id,e.currentRowIdx=V.lines.from[t.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(q.sortByColumns,q.sortTypes);q.scrollToCell(de[0],i.indexOf(t.id))}),500)}})),W.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),D.addProperty("similarityLimit","double",C),A=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),o.shell.o=e.root,e}(),D}var fe,ge=n(2003),ye=n(3516),be=n(6718),ve=n(3077),we=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var Ce=n(9192);class Ae{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Se extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ae}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var xe,Ee,_e,Me=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function Ie(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function Te(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(xe||(xe={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Ee||(Ee={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(_e||(_e={})),Object.prototype.toString;var Le=n(6873),Ne=n(4356),$e=n(6717),Pe=n(4870),Re=n(3856),Oe=n(6882),ke=n(7278),Ge=n(5553),Fe=n(6642),He=n(3599),Be=n(673),De=n(8312);class Ve extends Fe.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,Bi.logger),(0,be.pj)().then((e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,De.Q)().then((e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var je=n(4139);const Ue=ge.zS;function We(e){const t=!re().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,r]of re().enumerate(e)){let o=t;r<e.length&&(o+=`${t?"":"-"}${i}`),n.push(o)}return[n,t]}class qe extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=Bi.seqHelper}getRendererBack(e){const[t,n,i]=(0,Fe.BG)(e);if(n.meta.units!==ge.Hi.CUSTOM)return i.rendererBack;let r=null;return this.seqHelper&&(r=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),r}onClick(e,t){if(e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate(),e.cell.column.meta.units===ge.Hi.CUSTOM){const n=this.getRendererBack(e);n?.onClick(e,t)}}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Ge.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe((e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,r,o,s){const[a,l,c]=(0,Fe.BG)(o);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(Bi.properties?Bi.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new Oe.Jy(a,l,Bi.logger,d,(()=>{const{font:e,fontWidth:t}=Oe.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:u.isMsa()?8:0,monomerToShort:Ue}})),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,p.init().then((()=>{}))),p.render(e,t,n,i,r,o,s)}render(e,t,n,i,r,o,s){if(o.cell.column?.meta?.units!==ge.Hi.CUSTOM)this.renderInt(e,t,n,i,r,o,s);else{const a=this.getRendererBack(o);a?.render(e,t,n,i,r,o,s)}}}class ze extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell.value??"",h=this.tableCol.tags[ge.gp.separator],u=this.tableCol.meta.units;i=(0,Oe.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=(0,ke.Iv)(u,h),f=m(d),g=m(p),y=re().count(0).take(f.length).map((e=>f.getCanonical(e))).toArray(),b=re().count(0).take(g.length).map((e=>g.getCanonical(e))).toArray(),v=this.tableCol.getTag(ge.gp.alphabet);Ke(e,t,n,i,r,y,b,v===ge.YI.RNA||v===ge.YI.DNA?He.o.NUCLEOTIDE:He.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let r=i.rendererBack;return r||(r=i.rendererBack=new ze(t,n)),r}}class Ye extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return je.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,r,o,s){ze.getOrCreate(o).render(e,t,n,i,r,o,s)}}function Ke(e,t,n,i,r,o,s,a,l,c,h){if(o.length!==s.length){const e=function(e,t){let n=0,i=0;const r=e.length>t.length?e:t,o=e.length>t.length?t:e;for(let e=0;e<o.length;e++)r[e]===o[e]&&n++;const s=r.length-o.length;for(let e=r.length-1;e>s;e--)r[e]===o[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(we.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(re()(t).toArray()):e=l(re()(e).toArray()),{subParts1:e,subParts2:t}}(o,s);o=e.subParts1,s=e.subParts2}const u=e.measureText(We(o).join("")),d=e.measureText(We(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*o.length,e.canvas.width=p+4*o.length);let m=Math.max(t,t+(i-(p+4*o.length))/2)+5;const f=Math.max(n,n+(r-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*o.length:i,r),e.clip(),e.font="12px monospace",e.textBaseline="top";const u=7;for(let t=0;t<o.length;t++){const n=o[t],c=s[t];let d=Oe.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let o=Oe.S$;l&&(o=l.getMonomerTextColor(a,c));const s=(0,Re.oZ)(e,n,m,f-u,i,r,{color:d,pivot:0,left:!0}),p=(0,Re.oZ)(e,c,m,f+u,i,r,{color:o,pivot:0,left:!0});m=Math.max(p,s),h&&(h[t]=Ze(n,c,d,o,f,u,r))}else m=(0,Re.oZ)(e,n,m,f,i,r,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Ze(e,t,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(We([e]).join("")).width,h=l.measureText(We([t]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,r-o,u,s,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,r+o,u,s,{color:i,pivot:0,left:!0}),a}var Xe,Je=n(8070),Qe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Xe||(Xe={}));const et=new class{constructor(){this.regionTypes=[Xe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Qe.fH.Entropy,this.filterSource=Qe.Fo.filterSource}};var tt=n(7602),nt=n(8047);const it=Xe;var rt,ot;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(rt||(rt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ot||(ot={}));const st=et;class at extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ot.skipEmptyPositions,st.skipEmptyPositions,{category:rt.DATA}),this.regionTypes=this.stringList(ot.regionTypes,st.regionTypes,{category:rt.DATA,choices:Object.values(it).filter((e=>e!=it.Unknown))}),this.chains=this.stringList(ot.chains,st.chains,{category:rt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ot.fitWidth,st.fitWidth,{category:rt.LAYOUT}),this.positionWidth=this.float(ot.positionWidth,st.positionWidth,{category:rt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ot.positionHeight,st.positionHeight,{category:rt.LAYOUT,choices:Object.keys(Qe.fH)}),this.filterSource=this.string(ot.filterSource,st.filterSource,{category:rt.BEHAVIOR,choices:Object.values(Qe.lT)}),this.viewSyncer=new tt.g(Bi.logger)}static viewerCounter=-1;viewerId=++at.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case ot.regionTypes:case ot.chains:this.setData(this.regions)}switch(e.name){case ot.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ot.fitWidth:case ot.positionWidth:this.calcSize();break;case ot.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ot.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;Bi.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){Bi.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){Bi.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const o=t.find((t=>t.order==n[e]&&t.chain==r));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(Qe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Bi.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Bi.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,r=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[nt.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(ot.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[nt.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,Je.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}var lt=n(6625),ct=n(6863);async function ht(e,t,n="Morgan"){const i=e.length,r=Bi.seqHelper.getSeqHandler(e),o=Array(i);let s=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<i;t++){if(null===l[c[t]]||e.isNone(t)){o[t]=null;continue}o[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[t]+=a.get(i)}}let h={};if(t===ct.Z.MONOMER_CHEMICAL_DISTANCE||t===ct.Z.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,be.A7)(e,n),i={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{i[a.get(e)]=t}));const r=o.reduce(((e,t)=>Math.max(e,t.length)),0);h={scoringMatrix:t.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:h}}var ut=n(8115);function dt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))})),t}function pt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},r=Bi.seqHelper.getSeqHandler(e.seqCol),o=r.defaultBiotype,a=ft(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),o,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function ft(e,t,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");r.height=30;const s=Bi.monomerLib;return Ke(o,0,0,0,30,re().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),re().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),n,s,!0,i),r}function gt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function yt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class bt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{}}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>{this.gridSelect||this.render(e)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(e),this.debounceTimer=null}),100)}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class vt extends bt{distanceMetric;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;constructor(e,t){super(e,t),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS})}async onTableAttached(){super.onTableAttached(),this.dataFrame&&(this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3)}}const wt={gapPenalty:1,matchScore:1,gapSymbol:we.b9[we.Hi.FASTA],localAlignment:!1};class Ct extends vt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init((e=>this.targetColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.targetColumn.getTag(e))));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe((e=>{n&&clearTimeout(n),this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(t)}),300),this.gridSelect=!0})),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Pe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Pe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await ht(this.targetColumn,ct.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new H).getKNN(n,ct.Z.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,r=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(r),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(e.currentRowIdx),u=function(e,t,n={}){const i={...wt,...n},r=e.length,o=t.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,h=i.localAlignment?l[1]:o,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(e.getCanonical(c-1)),d.push(t.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(e.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(t.getCanonical(h-1)),h-=1):(u.push(e.getCanonical(c-1)),d.push(t.getCanonical(h-1)),c-=1,h-=1)}u=[...re().count(0).take(c).map((t=>e.getCanonical(t))),...u.reverse(),...i.localAlignment?re().count(l[0]).take(r).map((t=>e.getCanonical(t))):[]],d=[...re().count(0).take(h).map((e=>t.getCanonical(e))),...d.reverse(),...i.localAlignment?re().count(l[1]).take(o).map((e=>t.getCanonical(e))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new ke.Mu(u,i.gapSymbol),seq2Splitted:new ke.Mu(d,i.gapSymbol)}}(c,h),d=ft(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),o.shell.o=p.root}}var At=n(1407);class St extends vt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){const e=this.seqHelper.getSeqHandler(this.targetColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.targetColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.targetColumn.getTag(e))));const i=a.DataFrame.fromColumns([n]);n.temp[".mm.cellRenderer.maxMonomerLength"]=4,i.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]}));const r=i.plot.grid();(0,Pe.Kd)(r,n.name,450,30),(0,Pe.Ku)(this.root,r.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,At.R)(this.targetColumn,this.seqHelper);a.DataFrame.fromColumns([e]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await ht(this.targetColumn,ct.Z.LEVENSHTEIN)).seqList,t=new F(!0,!1),n=await t.calc(e,ct.Z.LEVENSHTEIN);t.terminate();const i=this.targetColumn.length,r=(o=i,(e,t)=>o*e+t-Math.floor((e+2)*(e+1)/2));var o;this.renderMolIds=function(e,t,n){function i(e,t){let n=null,i=null;for(const r of e){const e=t(r);(null==i||e>i)&&(n=r,i=e)}return n}const r=[(s=e-1,Math.floor(function(e){return Math.random()*e}(s)))],o=new Set;var s;for(let t=0;t<e;++t)r.includes(t)||o.add(t);for(;r.length<t;){const e=i(o.values(),(e=>Math.min.apply(Math,r.map((function(t,i){return n(e,t)})))));null!=e&&(r.push(e),o.delete(e))}return r}(i,Math.min(i,this.limit),((e,t)=>this.targetColumn.isNone(e)||this.targetColumn.isNone(t)?0:n[r(e,t)]))}}var xt,Et=n(5433),_t=n(3890),Mt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(xt||(xt={}));class It{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[e,t,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Tt extends It{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Lt extends Tt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(xt.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(xt.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),r=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(xt.TYPE)&&-1!==e.indexOf(xt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,xt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<xt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,xt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,xt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+xt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=xt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends Tt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Lt(e);if($t.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Lt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Pt=n(6197),Rt=n(9124),Ot=n(3527);class kt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,r=void 0,o=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=r,this.mt=o,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++kt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Gt extends kt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Ft extends kt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Ht extends kt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Bt extends kt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Dt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,r,o,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=r,this.mt=o,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const r=t.symbol,o=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{i[e.label]=e.capGroupName}));else{if(!o){if(t.lib)return new Bt(e,r);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(o)}const s=new Dt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Vt={[He.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[He.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[He.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[He.o.CHEM]:{R:"#eeeeee"},[He.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},jt=/[\w()]+/,Ut=RegExp(String.raw`\(${jt}(,${jt})+\)`),Wt=e=>{const t=s.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},qt=new Ot.Mi([255,255,255]),zt=new Ot.Mi([0,0,0]),Yt=.7*(0,z.wQ)(qt);class Kt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length));for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==we._S||t===we.b9[we.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:re().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{Bi.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,Rt.fA)(e,t),r=(0,Pt.Y)(n);let o=this.getMonomer(r,i);if(o&&n==He.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==He.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(r,i));let s=o.wem??null;return s||(i===we._S||"*"==i?s=o.wem=new Gt(n):n===He.o.NUCLEOTIDE&&"N"===i||n===He.o.AA&&"X"===i||(He.o.CHEM,0)||Ut.test(i)?s=o.wem=new Ft(n,i):o.lib||(s=o.wem=new Ht(n,i,this.isEmpty)),s||(s=o.wem=Dt.fromMonomer(n,o,this))),s}getTooltip(e,t){const n=(0,Pt.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),r=this.getWebEditorMonomer(e,t),o=this.getMonomer(n,t);if(o){const e=o.symbol,[t,n,a]=(o.name,r?[r.textcolor,r.backgroundcolor,r.linecolor]:["#202020","#A0A0A0","#202020"]);let l;i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([o.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=o.molfile?Wt(o.molfile):o.smiles?s.divV([Wt(o.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),o.symbol!=we._S&&i.append(s.divText(o.lib?.source??"Missed in libraries"))}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},r=i(n.textcolor),o=new Ot.Mi([...r.map((e=>e+1))]),s=(0,z.KE)(o,qt)/((0,z.wQ)(o)*(0,z.wQ)(qt)),l=i(n.backgroundcolor),c=new Ot.Mi([...l.map((e=>e+.01))]);let h;h=(0,z.KE)(c,qt)/((0,z.wQ)(c)*(0,z.wQ)(qt))<s?l:r;let u=new Ot.Mi(h);const d=(0,z.wQ)(u);return d>Yt&&(u=(0,z.dC)(zt,u,Yt/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(e,t){const n="default";let i=n;const r=(0,Pt.Y)(e),o=this.getMonomer(r,t);let s;if(o){if(o.meta&&o.meta.colors){const e=o.meta.colors;n in e||(i="default"),s=e[i]}if(!s){const t=Vt[e],n=t?.[o.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=o.naturalAnalog;if(!s&&t)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,r="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(r+=t[e][n]);n["R"+i]=r,r=""}return n}}var Zt=n(5488),Xt={};Xt.styleTagTransform=A(),Xt.setAttributes=b(),Xt.insert=g().bind(null,"head"),Xt.domAPI=m(),Xt.insertStyleElement=w(),d()(Zt.A,Xt),Zt.A&&Zt.A.locals&&Zt.A.locals;class Jt extends Kt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{Bi.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,Pt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Ne.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const r=e.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((e=>e.lib?.source===r));o?this._monomers[n][i]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of re().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}static overrideCounter=0;override(e,t){return new Qt(e,`override: ${++Jt.overrideCounter}, ${t}`,this)}}class Qt extends Kt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,r){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,Ce.AP)(e);this.error=t,this.monomers=[]}}}class tn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nn=n(7433),rn=n.n(nn),on=n(1913),sn=n.n(on);class an{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});sn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const r of e){const e=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,r,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${e}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}var ln=n(8604);class cn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let r;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let o=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((e=>r=e))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),o||(o=!0,r())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++cn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await o.dapi.files.readAsText(ln.gt),r=JSON.parse(i),s=new an(r);return new cn(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists(ln.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText(ln.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists(ln.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete(ln.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists(ln.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),r=await i.readAsText(t);n=JSON.parse(r);const o={},s=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(o[t]={},s.push(t)),o[t][n]=e})),new Jt(o,t)}async loadSetFromFile(e,t,n){let i={};const r=new a.FileSource(t),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,r=n.polymerType,o=n.monomerType,s=n.set;return new en(e,i,r,o,s)}));return new tn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(ln.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${ln.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Bi.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Bi.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Bi.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText(ln.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Bi.logger.debug(`${e}, OUT`)})),Bi.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(ln.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ln.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(ln.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ln.Es.length)))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class un{logger;_monomerLib=new Jt({},"MAIN");_monomerSets=new tn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Je.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++un.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return un.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await cn.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Ne.ub)()]),r=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((e=>this.readLibrary(ln.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Jt({},e,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((t=>this.readSet(ln.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const 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V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:bn};async function wn(e,t,n=0){if(!Object.keys(vn).includes(t))return null;const i=await async function(e){const t=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;const r=vn[t];let o=0,s=null;for(const[e,t]of Object.entries(r)){const r=(0,O.$1)(i,t);r>o&&r>=n&&(o=r,s=e)}return s}var Cn,An=n(857),Sn={};Sn.styleTagTransform=A(),Sn.setAttributes=b(),Sn.insert=g().bind(null,"head"),Sn.domAPI=m(),Sn.insertStyleElement=w(),d()(An.A,Sn),An.A&&An.A.locals&&An.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Cn||(Cn={}));const xn={[Cn.MONOMER]:a.COLUMN_TYPE.STRING,[Cn.SYMBOL]:a.COLUMN_TYPE.STRING,[Cn.NAME]:a.COLUMN_TYPE.STRING,[Cn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Cn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Cn.AUTHOR]:a.COLUMN_TYPE.STRING,[Cn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Cn.ID]:a.COLUMN_TYPE.INT,[Cn.META]:a.COLUMN_TYPE.STRING,[Cn.SOURCE]:a.COLUMN_TYPE.STRING};class En{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Cn.NAME).width=100,this.tv.grid.col(Cn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=gn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Ln(e,(()=>this.activeMonomerLib),(async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout((()=>{const n=t.col(Cn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new En(e)}return this.instance}static async getNewInstance(){const e=await un.getInstance();return await e.awaitLoaded(),await e.loadLibrariesPromise,new En(e)}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await o.dapi.files.writeAsText(ln.so+e,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(e)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)o.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(o.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(()=>{this.cloneMonomer(this.tv.dataFrame.rows.get(t))})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>On(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>On(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(()=>{const e=On(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter((e=>e.name===En.VIEW_NAME)).forEach((e=>e.close()))}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e?o.shell.v=e:En.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach(((e,t)=>{i[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((e=>e.length>0));const r=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.icons.edit((()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||this.cloneMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),c=s.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=t.map((e=>On(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=On(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(c,(()=>(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]).length>0?"Delete selected monomers":"Delete monomer"));const h=s.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{t=await o.dapi.files.readAsText(ln.so+e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");i.push([r,l,c,h]),this.tv.setRibbonPanels(i),this.tv.name=En.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const u=this._newMonomerForm.form;return u.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(u,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}cloneMonomer(e){return this._newMonomer=On(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(ln.so,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),a.DataFrame.create();const t=this.activeMonomerLib.getPolymerTypes().flatMap((e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map((t=>this.activeMonomerLib.getMonomer(e,t))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const r=Array.from(i);r.sort();for(const[e,t]of Object.entries(xn))if(n.columns.addNew(e,t),e===Cn.R_GROUPS)for(const e of r)n.columns.addNew(e,a.COLUMN_TYPE.STRING);n.col(Cn.SYMBOL).semType="Monomer",n.col(Cn.SYMBOL).setTag(Re.Mn.applyToBackground,"true");for(let e=0;e<t.length;e++){let i=$n(t[e].rgroups,t[e].smiles,t[e].molfile);i=_n(i),t[e].rgroups=Tn(t[e].rgroups);const o=r.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?In(i,"capGroupSmiles"):""}));n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...o,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,t[e].createDate,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""])}return n.col(Cn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((e=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;this.cloneMonomer(n.rows.get(n.currentRowIdx))}catch(e){console.error(e)}})),n}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const Mn=["alternateId","capGroupName","capGroupSMILES","label"];function In(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function Tn(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(Mn,e),n=In(t,"capGroupSMILES"),i=In(t,"alternateId"),r=In(t,"capGroupName"),o=In(t,"label")??"R1";if(n&&i&&r||o.length<2)return t;if(i&&-1!==i.indexOf(`${o}-`)){const e=i.replace(`${o}-`,"");r||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${o.substring(1)}][${e}]`)}else r&&(n||(t.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(t.alternateId=`${o}-${r}`));return t})).sort(((e,t)=>e.label?.localeCompare(t.label??"")??0))}class Ln{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new kn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=$n([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((e=>e[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items=i.sort(((e,t)=>e.label?.localeCompare(t.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const r=await wn(Rn(t,i),this.polymerTypeInput.value??"");r&&(this.monomerNaturalAnalogInput.value=r)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new yn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new yn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Tn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter((([e,t])=>"colors"!==e?.toLowerCase())).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),e.naturalAnalog||wn(Rn(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}));const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=$n(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await o.dapi.files.readAsText(ln.so+t);i=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const r=e.map((e=>Nn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=r.map((e=>i[e])),l=s.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await o.dapi.files.writeAsText(ln.so+t,JSON.stringify(i,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),u.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await o.dapi.files.readAsText(ln.so+t);n=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const i=Nn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),r=this.getMonomersDataFrame()?.col(Cn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{const i=n.findIndex((t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText(ln.so+t,JSON.stringify(n,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const e=On(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=$n([],e);let t=o.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=Pn(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(r,s):o.shell.warning("Monomer library source is not specified")}}function Nn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function $n(e,t,n){const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(r,e),r=_n(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function Pn(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")||e.includes("V3000"))),r=Number.parseInt(t[i].trim().split(" ")[0]),o={};for(let e=i+1;e<i+1+r;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const r=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(o[e-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[e-i]=s)}const s=Object.keys(o);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(o).map((([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`)).join("")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return s.filter((e=>!!Number.parseInt(e))).map((e=>Number.parseInt(e)+i)).forEach((e=>{const n=t[e].split(" "),i=n.findIndex((e=>"R#"===e));if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}})),t.join("\n")}function Rn(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=In(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}function On(e){const t=JSON.parse(e.get(Cn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e]));const n=e.get(Cn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=Pn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}return{symbol:e.get(Cn.SYMBOL),name:e.get(Cn.NAME),molfile:i,smiles:n,polymerType:e.get(Cn.POLYMER_TYPE),monomerType:e.get(Cn.MONOMER_TYPE),naturalAnalog:e.get(Cn.NATURAL_ANALOG),id:e.get(Cn.ID),rgroups:JSON.parse(e.get(Cn.R_GROUPS)??"[]"),meta:t,author:e.get(Cn.AUTHOR),createDate:e.get(Cn.CREATE_DATE)}}class kn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Gn(e)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,e),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),r.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Hn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Hn._instance||(Hn._instance=new Hn,await Hn._instance.refresh(),(await un.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Hn._instance.refresh()))),Hn._instance.refresh(),Hn._instance}async refresh(){this.settings=await(0,Ne.ub)();const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[t][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Ne.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),e.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Bn(){await Un.showDialog()}async function Dn(e=!0){return await Wn.showView(e)}class Vn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Vn.instancePromise&&(Vn.instancePromise=(async()=>{const e=new Vn,t=await(0,be.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Vn.instancePromise}static async reloadWidget(){const e=await Vn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,be.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await jn.createControlsForm();return pn()(e).addClass("monomer-lib-controls-form"),setTimeout((()=>{e&&pn()(e)&&pn()(e).removeClass("ui-form-condensed")}),200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class jn{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([e,t])=>{this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Bi.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,be.pj)().then((e=>e.getFileManager())),await(0,Ne.ub)()]);return new jn(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.wideForm(e,void 0);return pn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();pn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;Bi.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=s.icons.edit((async()=>{o.shell.v=await(await En.getInstance()).getViewRoot(e)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${e}`),i.addOptions(a),i.addOptions(r),Bi.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Ne.Eu)(this.userLibSettings);const n=await(0,be.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class Un{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){Un._instance||(Un._instance=new Un,Un._instance.closeDialogSubject$.subscribe((()=>{Un._instance.dialog=void 0}))),Un._instance.dialog||(Un._instance.dialog=await Un._instance.getDialog()),Un._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Vn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});pn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class Wn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Vn.getInstance()).widget,i=s.bigButton("Add",(()=>t.addLibraryFile()),"Upload new HELM monomer library"),r=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,r])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);return this._view=a.View.fromRoot(l),this._view.name=Wn.viewName,e&&o.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const e=Array.from(l.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;t.style.width=`${r}px`;const o=i-r;n.style.width=`${o}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((()=>{try{const e=Wn._instance;e&&e._view&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))})),this._view}static async showView(e=!0){return Wn._instance||(Wn._instance=new Wn),Wn._instance._duplicateManager||(Wn._instance._duplicateManager=await Hn.getInstance()),Wn._instance.libManager||(Wn._instance.libManager=await un.getInstance()),e&&Wn._instance._view&&Array.from(o.shell.views).find((e=>e.id&&e.id===Wn._instance._view.id))?(o.shell.v=Wn._instance._view,await Wn._instance._duplicateManager.refresh(),Wn._instance._view):(Wn.closeExistingViews(),Wn._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter((e=>e.name===Wn.viewName)).forEach((e=>e.close()))}async mergeSelectedLibs(){const e="Library with this name already exists",t=await un.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=h(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=r.value;return e.endsWith(".json")||(e+=".json"),e}function h(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}r.addValidator(h),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(t,e,!1);const n=await(0,Ne.ub)();n.exclude=l,await(0,Ne.Eu)(n),await this.libManager.loadLibraries(!0),await Vn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var qn,zn=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};class Yn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((e=>zn(this,void 0,void 0,(function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find((e=>e.text===t))})))),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",(()=>{o.shell.v.close(),o.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var r,o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>zn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>zn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>zn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._path=null!==(o=null==i?void 0:i.path)&&void 0!==o?o:"",this._progress.max=0,this._progress.value=1,Yn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return zn(this,void 0,void 0,(function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Je.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof a.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return zn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return zn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),e.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return zn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return zn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Yn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return zn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Yn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(qn||(qn={}));var Kn=n(966),Zn=n(608),Xn=n(1619);class Jn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=re()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Bi.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case nt.n5.fixWidth:case nt.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Qn{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ei=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};class ti extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,r,o,s){e.save();try{if(o.gridRow<0)return;const s=o.cell?.column&&"true"===o.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=o.cell.value;if(!a||a==we._S)return;let l=Oe.S$,c="rgb(255, 255, 255)";if(this.monomerLib){const e=this.tableCol.getTag(we.gp.alphabet),t=e===ge.YI.RNA||e===ge.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA;if(s){const e=this.monomerLib.getMonomerColors(t,a);l=e?.textcolor??l,c=e?.backgroundcolor??c}else l=this.monomerLib.getMonomerTextColor(t,a)}const h=Math.max(2,Math.floor(.15*i));s&&(e.fillStyle=c,e.fillRect(t,n,i,r)),e.fillStyle=l,e.fillText((0,ge.zS)(a,h),t+i/2,n+r/2,i)}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(we.gp.alphabet),i=e.cell.value,r=e.grid.canvas.getBoundingClientRect(),o=e.bounds.right+r.left-4,a=e.bounds.bottom+r.top-4;if(i==we._S)return s.tooltip.show(s.divText("gap"),o,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),o,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA,c=this.monomerLib.getTooltip(l,i);return s.tooltip.show(c,o,a),!0}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let r=i.rendererBack;return r||(r=i.rendererBack=new ti(t,n)),r}}class ni extends a.GridCellRenderer{get name(){return je.uF.MONOMER}get cellType(){return je.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,r,o,s){ti.getOrCreate(o).render(e,t,n,i,r,o,s)}onMouseMove(e,t){ti.getOrCreate(e).onMouseMove(e,t)}}class ii{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ri extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class oi extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ii(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Ce.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var si=n(2174);class ai extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=Bi.properties.tooltipWebLogo,n=this.seqCol.getTag(Qe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function li(e,t,n,i){const r=Bi.seqHelper.getSeqHandler(e);let o=null,s=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(o=e),r.posList[e]==n&&(s=e);if(null===o&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(o,s,a)}const ci={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class hi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??ci;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Bi.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ui{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),i.options.add(r)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const r=e.options[i],o=JSON.parse(r.value);o&&t===o.start&&n===o.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Bi.handleErrorUI(e)}))})).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=s.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Bi.handleErrorUI(e)}))}));return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var di=n(8754);async function pi(e,t,n,i,r){const o=await async function(e,t,n,i,r){const o=(0,ve.R)(t,r),s=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=r.getSeqHandler(s).getSplitted(0),c=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):we._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===o[t]&&++l[n];l[n]/=e.length}return s}(l,o):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,be.uL)(i,e,n)}(l,o,r):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,r);for(let e=0;e<o.length;e++)t.isNone(e)&&o.set(e,null,!1);return o}var mi=n(294),fi=n(330);const gi=OCL;var yi=n(9099);class bi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var vi=n(6956);class wi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===vi.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Ci{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,r=n*Math.cos(e)-i*Math.sin(e),o=n*Math.sin(e)+i*Math.cos(e);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:o}}))}}class Ai extends Ci{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Si{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class xi extends Si{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Ei extends bi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Ai(n),this.bonds=new xi(n),this.rGroups=new wi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class _i extends Ci{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,r,a)=>t+o+i+s+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Mi extends Si{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,r,o,s)=>`${n}${t[0]}${r}${t[1]}${s}`))}))}}class Ii extends bi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new _i(n),this.bonds=new Mi(n),this.rGroups=new wi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ti{static getInstance(e,t){if($t.isMolfileV2K(e))return new Ei(e,t);if($t.isMolfileV3K(e))return new Ii(e,t);throw new Error("Unsupported molfile version")}}class Li{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,r,o){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=Ti.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Li.molfileV2KToV3KCache.has(e))return Li.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Li.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ni{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new yi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===we.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,r=new Li(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(r)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new mi.Cg;for(const[n,r]of re().enumerate(this.monomerWrappers)){const o=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(r)?He.o.NUCLEOTIDE:He.o.AA;i.set(r,{biotype:a,symbol:n.monomerSymbol,atoms:re().count(o).take(n.atomCount).toArray(),bonds:re().count(s).take(n.bondCount).toArray()})}const r=e.length,o=t.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END BOND"].join("\n")}}class $i{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Pi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,r=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(r,n.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return gi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,Ce.AP)(e);return Bi.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;r.update(t,`${t?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const r=e.dataFrame,o=this.convertToMolfileV3KColumn(e).toList().map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),s=`molfile(${e.name})`,l=r?r.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(o,l):a.Column.fromStrings(l,o.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map((e=>e.molfile)),i=(0,fi.kA)(t,`molfileV2K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=mi.vF.createEmpty();continue}let r;try{r=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,Ce.AP)(e);Bi.logger.error(t,void 0,n),r=mi.vF.createEmpty()}t[n]=r}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const r=this.helmHelper.getMolfiles([n])[0],o=new $i(r),s=new Ni(n,this.rdKitModule,this.monomerLib);o.monomerSymbols.forEach(((e,t)=>{const n=o.getMonomerShifts(t);s.addMonomer(e,t,n)}));const a=s.compileToMolfile(),l=new mi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new mi.vF(a.molfile,l)}}const Ri=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class Oi extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(e){this.seqHandler.column.set(this.rowIdx,e)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===we.YI.DNA}isRna(){return this.seqHandler.alphabet===we.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===we.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(e,t){if(null==t.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=t.column.dataFrame.cell(e,t.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=e,this.seqHandler=t}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const e=(0,ke.qp)(this.helm),t=[],n=/\(|\)/;for(let i=0;i<e.length;i++){const r=e.getOriginal(i),o=r.split(n).filter((e=>!!e));3===o.length?(t.push(o[0]),t.push(o[1]),t.push(o[2])):t.push(r)}return new ke.Mu(t,this.seqHandler.defaultGapOriginal)}}class ki{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ri.notationProvider]??null);const i=this.isFasta()?we.b9[ge.Hi.FASTA]:this.isSeparator()?we.b9[ge.Hi.SEPARATOR]:this.isHelm()?we.b9[ge.Hi.HELM]:this.isCustom()?this.notationProvider.defaultGapOriginal:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,ke.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,ke.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?He.o.NUCLEOTIDE:He.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getValue(e,t){return this.column.get(e),new Oi(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...re().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map((e=>e.trim())):re().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const r=this.column,o=e.toLowerCase()+"("+r.name+")",s=n??r.dataFrame?.columns.getUnusedName(o)??o,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=r.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let h=r.getTag(ge.gp.alphabet);h||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(h=ge.YI.UN),null!=h&&l.setTag(ge.gp.alphabet,h);let u=r.getTag(ge.gp.alphabetSize);null!=h&&u&&l.setTag(ge.gp.alphabetSize,u);const d=r.getTag(ge.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,u)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!ki.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:ke.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ct.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return ct.Z.LEVENSHTEIN}getDistanceFunction(){return ct.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,be.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let e=0;e<i;++e){const i=r[e];if(!(i in n)){n.add(i);const r=this.getSplitted(e);for(let e=0;e<r.length;++e){const n=r.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?we.b9[ge.Hi.FASTA]:we.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),o=(0,ge.qp)(e),s=[];for(let e=0;e<o.length;++e){let n=o.getOriginal(e);if(r&&(n=n.replace(gn.EK,"$1")),n===we.b9[ge.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=e??0,o=t??this.maxLength-1,s=this.getJoiner(),a=o-r+1,l=we.b9[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=r+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new ke.Mu(n,l))}));const c=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(a);for(let e=0;e<a;++e){const i=r+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},h=this.column.getTag(ge.gp.positionNames);h&&i.setTag(ge.gp.positionNames,c(h));const u=this.column.getTag(ge.gp.positionLabels);return u&&i.setTag(ge.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const r=this;switch(t){case ge.Hi.FASTA:i=function(e){return r.joinToFasta(e,r.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Gi(e,n,r.isHelm())};break;case ge.Hi.HELM:{const e=r.alphabet===ge.YI.DNA||r.alphabet===ge.YI.RNA,t=r.getHelmWrappers();i=function(n){return Fi(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e,t){let n=e.temp[Ri.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Ri.seqHandler]=new ki(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const r=e.getOriginal(i);let o=e.getOriginal(i);t&&(o=o.replace(gn.EK,"$1")),r===we._S?o=we.b9[ge.Hi.FASTA]:r===gn.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Gi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return Fi(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let o=t.getOriginal(e);(i||r)&&(o=o.replace(gn.EK,"$1"),o=o===gn.q7?null:o),n[e]=o||null}return new ke.Mu(n.filter((e=>!!e)),we.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(e,t)),i}}function Gi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let o=e.getOriginal(t);n&&(o=o.replace(gn.EK,"$1")),r===we._S?o=we.b9[ge.Hi.SEPARATOR]:r===gn.q7&&(o=""),i[t]=o}return i.join(t)}function Fi(e,t,n){const[i,r,o,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=e.getOriginal(t);i===we._S?s=we.b9[ge.Hi.HELM]:(n&&(s=s.replace(gn.EK,"$1")),s=1===s.length?`${r}${s}${o}`:`${r}[${s}]${o}`),a[t]=s}return`${i}${a.join(".")}${s}`}class Hi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return ki.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Rt.b2)();return new Pi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return mi.vF.createEmpty();const r=t.convertToMolfileV3K([e])[0];if(!r||!r.molfile)return mi.vF.createEmpty();let o=null;try{let e=r.molfile;if(i){if(o=this.rdKitModule.get_mol(e),!o)return mi.vF.createEmpty();o.set_new_coords(),o.normalize_depiction(1),o.straighten_depiction(!0),e=o.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new mi.vF(e,r.monomers)}catch(e){const[t,n]=(0,Ce.AP)(e);return Bi.logger.error(t,void 0,n),mi.vF.createEmpty()}finally{o?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),o=e.dataFrame,s=(0,fi.qj)(o,e.name),l=await this.getHelmToMolfileConverter(r),c=e.toList(),h=new Array(e.length),u=a.Func.find({package:"Chem",name:"beautifyMols"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(c[n],l,t,!u).molfile;if(u){const t=await u.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}const d=a.Column.fromStrings(s,h);return d.semType=a.SEMTYPE.MOLECULE,d.meta.units=a.UNITS.Molecule.MOLBLOCK,d.setTag(".sequence-src-col",e.name),{molCol:d,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,ki.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.SEPARATOR)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),ki.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,ki.setTags(e)}}const Bi=new oi;async function Di(){return await un.getInstance()}class Vi{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}let ji=null;async function Ui(){null===ji&&(ji=async function(){const e="Bio: _package.initBio()";Bi.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,$e.j)(),i=await Bi.getProperties(),r=new ri(i);Bi.properties=r;const o=await un.getInstance(),s=await(0,Ne.ub)();s.explicit&&(s.explicit=[],await(0,Ne.Eu)(s)),await o.awaitLoaded(1/0),o.initialLoadCompleted||await o.loadMonomerLib(),o.loadMonomerSets();const a=o.getMonomerLib(),l=o.getMonomerSets(),c=window.performance.now();Bi.logger.debug(`${e}, loading ET: ${c-t} ms`);const h=new Hi(o,n);Bi.completeInit(h,a,l,n),Bi.logger.debug(`${e}, end`)}()),await ji}function Wi(e){const t=new ai(e,Bi.seqHelper);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)})),t}function qi(){return Bi.monomerLib}function zi(e){return Bi.seqHelper.getSeqHandler(e)}function Yi(e){const t="getRegionTopMenu",n=a.Func.find({package:Bi.name,name:t});if(1!==n.length)throw new Error(`Package '${Bi.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new ui(i,Bi.seqHelper).widget()}async function Ki(e){return async function(){const e=s.label("Manage monomer libraries");return pn()(e).addClass("d4-link-action"),e.onclick=async()=>await Bn(),new a.Widget(e)}()}function Zi(e){try{new ui(e,Bi.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),Bi.logger.error(t,void 0,n)}}function Xi(e){const t=new Qn;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function Ji(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function Qi(e){const t=new Se({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function er(){return new qe}function tr(){return new qe}function nr(){return new qe}function ir(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=Bi.properties?Bi.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let r=Bi.properties?Bi.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(r=e.temp[".mm.cellRenderer.fontSize"]);const o=s.input.int("Font Size",{value:r,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference 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h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(e,t,i,r,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==h.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=Ie(e);function x(n,r,o){let 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t=s.divText(""),n=a.Widget.fromRoot(t);try{if(!e||!e.value)return t.innerText="No sequence provided",n;if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t.innerText="Atomic level conversion requeires a sequence column",n;if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].includes(e.cell.column.meta.units?.toLowerCase()??""))return t.innerText="Unsupported sequence notation. please use Bio | Polytool | Convert",n;const i=(await ao()).getSeqHandler(e.cell.column);if(!i)return t.innerText="No sequence handler found",n;if((i.getSplitted(e.cell.rowIndex,50)?.length??100)>40)return t.innerText="Maximum number of monomers is 40",n;const r=a.Column.fromStrings("singleVal",[e.value]),l=a.DataFrame.fromColumns([r]);if(Object.entries(e.cell.column.tags).forEach((([e,t])=>{r.setTag(e,t)})),await fr(l,r,e.cell.column.meta.units===ge.Hi.HELM,!1),l.columns.length<2)return t.innerText="No structure generated",n;const c=l.columns.byIndex(1),h=c.get(0);if(!h)return t.innerText="No structure generated",n;c.semType=a.SEMTYPE.MOLECULE;const u=a.SemanticValue.fromTableCell(l.cell(0,c.name)),d=s.panels.infoPanel(u);let p=null;d&&(p=a.Widget.fromRoot(d.root));const m=o.chem.drawMolecule(h,300,300,!1);return m.style.cursor="pointer",s.tooltip.bind(m,"Click to expand"),m.onclick=()=>{const e=window.innerWidth-200,t=window.innerHeight-200,n=o.chem.drawMolecule(h,e,t,!1);s.dialog({title:"Molecule"}).add(n).showModal(!0)},p&&p.root.prepend(m),p??a.Widget.fromRoot(m)}catch(e){Bi.logger.error(e)}return t.innerText="No Structure generated",n}(e)}function br(){(0,Xn.D)({},Bi.seqHelper).catch((e=>{const[t,n]=(0,Ce.AP)(e);if(e instanceof Zn.Ap)return o.shell.warning(e.element),void Bi.logger.warning(t);o.shell.error(t),Bi.logger.error(t,void 0,n)}))}async function vr(e=null,t=null,n){return(0,Xn.D)({col:e,clustersCol:t,...n},Bi.seqHelper)}async function wr(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(Bi.seqHelper.getSeqHandler(e),!0))),n=async t=>{if(!(0,Kn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>Bi.seqHelper.getSeqHandler(e).isMsa())),r=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Cr(e){return new ye.m(e).importFasta()}function Ar(e){return console.log(e),[]}function Sr(){const e=(0,Pe.me)()[0];(0,Et.C)(e,Bi.seqHelper)}function xr(e){(0,Et.C)(e,Bi.seqHelper)}function Er(){return new ni}async function _r(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const t=await o.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${e}`,s}async function Mr(e,t){return await async function(e,t){if(await(0,Je.cb)(10),!(0,Kn.V)(t,"Sequence space"))return e;const n=Bi.seqHelper,i=(0,ve.R)(t,n);i.name="splitToMonomers";const r=t.dataFrame;for(const e of i.columns)e.semType=je.uF.MONOMER,e.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=e=>{s.lastIndex=0;const t=e.match(s);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=je.uF.MONOMER,n.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const o=100;let s=0;for(;r.columns.byName(n.name)&&s<o;)n.name=l(n.name),s++;r.columns.add(n)}await o.data.detectSemanticTypes(r);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return r}(e,t)}function Ir(e){return Bi.seqHelper.getSeqMonomers(e)}function Tr(){return new Ct(Bi.seqHelper)}function Lr(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function Nr(){return new St(Bi.seqHelper)}function $r(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function Pr(e){const t=(0,Pe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,Bi.seqHelper)}function Rr(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}async function Or(e,t,n){const i=Bi.seqHelper;return pi(e,t,n,fe.IDENTITY,i)}async function kr(e,t,n){const i=Bi.seqHelper;return pi(e,t,n,fe.SIMILARITY,i)}async function Gr(){Bn()}async function Fr(){await Dn()}async function Hr(){const e=await En.getInstance();await e.getViewRoot()}async function Br(){return await Dn(!1)}async function Dr(e,t){(await(await un.getInstance()).getFileManager()).getValidLibraryPaths().forEach((t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe((async()=>{const e=await En.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()}))}))}function Vr(){(0,_t.TE)()}function jr(){return new Mt._i(Bi.seqHelper,Bi.logger)}function Ur(){return new Mt._i(Bi.seqHelper,Bi.logger)}async function Wr(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Jn(e,"webLogoLargeApp"),n=await Bi.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function qr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Jn(e,"webLogoAggApp"),n=await Bi.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function zr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new hi(e,"getRegionApp");await t.init()}finally{e.close()}}async function Yr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await Bi.files.readCsv("samples/HELM_empty_vals.csv"),n=new hi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function Kr(){const e=a.DataFrame.fromColumns((0,Le.dW)());o.shell.addTableView(e)}function Zr(){const e=a.DataFrame.fromColumns([(0,Le.Hx)(Bi.seqHelper,ge.Hi.FASTA)]);o.shell.addTableView(e)}function Xr(){const e=a.DataFrame.fromColumns([(0,Le.Hx)(Bi.seqHelper,ge.Hi.HELM)]);o.shell.addTableView(e)}function Jr(e,t){!function(e,t,n){const i=n.getSeqHandler(e.column),r=Object.values(ge.Hi).filter((e=>e!==i.units));t.group("Copy").items(r,(t=>{const i=e.column,r=e.rowIndex,s=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?Bi.properties.defaultSeparator:void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t,Bi.seqHelper)}async function Qr(){await async function(){const e=await Bi.files.readCsv("samples/peptides-non-natural.csv");e.name="Similarity and Diversity Demo",e.col("activity").setTag("format","3 significant digits"),e.col("sequence").temp[".mm.cellRenderer.maxMonomerLength"]=4;const t=o.shell.addTableView(e);await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const n=t.addViewer("Sequence Similarity Search",{limit:20}),i=t.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.45);(0,Pe.Kd)(t.grid,"sequence",500,30);const r=t.addViewer("Sequence Diversity Search",{limit:20});t.dockManager.dock(r,a.DOCK_TYPE.DOWN,i,"Diversity search",.4),o.functions.call("Dendrogram:HierarchicalClustering",{df:o.shell.t,colNameList:["sequence"],distance:"euclidian",linkage:"complete"})}()}async function eo(){await async function(){const e=await o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function to(){await async function(){const e=await Bi.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await ur(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,ct.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),pn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const r=Array.from(t.viewers).find((e=>e!==t.grid&&e.type===a.VIEWER.GRID));r&&(r.props.rowHeight=40,r.col("seq_diff").width=600,t.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),Bi.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function no(){await async function(){const e=await Bi.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await fr(e,n,!0,!1),(0,Pe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Pe.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular structure.",{timeout:10}),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#get-atomic-level-structure")}()}async function io(e){const t=(0,be.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}async function ro(e,t){if(!e.trim())return"";try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"helm",[e]),i=a.DataFrame.fromColumns([n]),r=await o.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=(await Di()).getMonomerLib(),l=Bi.seqHelper,c=await(0,$e.j)(),h=(await(0,di.V)(i,n,t,!1,s,l,c))?.molCol?.get(0);return h??void 0}catch(e){const[t,n]=(0,Ce.AP)(e);throw Bi.logger.error(t,void 0,n),e}}async function oo(e,t){if(!e.trim())return null;try{const n=a.Column.fromList(a.COLUMN_TYPE.STRING,"seq",[e]),i=a.DataFrame.fromColumns([n]);if(!await o.functions.call("Bio:detectMacromolecule",{col:n}))throw new Error("Macromolecule required");return(await pi(i,n,t,fe.IDENTITY,Bi.seqHelper)).get(0)}catch(e){const[t,n]=(0,Ce.AP)(e);throw Bi.logger.error(t,void 0,n),e}}async function so(e,t,n){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(e),u=t?h.getCol(t):h.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Je.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}async function ao(){return await Ui(),Bi.seqHelper}function lo(e,t,n){return async function(e,t,n=!0,i){const r=Bi.seqHelper,o=(await r.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,Bi.rdKitModule,i);return 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const s=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>e&&(e=this.dpGrid[i][r].value,t=i,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}},8115:(e,t,n)=>{"use strict";n.d(t,{BQ:()=>m,a7:()=>u,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(8070),a=n(2003),l=n(1407),c=n(4870);const h="substr_helm";class u{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,c.Ku)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===a.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,c.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=o.DataFrame.create(1);t.columns.addNewString(h).init((e=>"")),t.col(h).semType=this.col.semType,t.col(h).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===a.Hi.HELM?t.get(h,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await p(n,this.col,this.seqHelper):d(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,r=e.charAt(e.length-1)===t,o=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(e,n):e,r=o.BitSet.create(t.length);for(let n=0;n<t.length;n++){const o=t.get(n);(o.match(i)||o===e)&&r.set(n,!0,!1)}return r}async function p(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await m(t,n,!0);const r=o.Column.string("helm",1).init((t=>e));r.semType=o.SEMTYPE.MACROMOLECULE,r.meta.units=a.Hi.HELM;const s=await(0,l.R)(r,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function m(e,t,n){const i=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,s.cb)(10);const i=new Map,r=await(0,l.R)(e,t,n,i);e.temp["monomeric-mols"]=r,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),r=n(6082),o=n(5605);function s(e,t,n=[],r=[],s=!0){const l=o._package.seqHelper,[c,h]=a(e,t,l,n,r);return s&&!c&&i.shell.warning(h),c}function a(e,t,n,o=[],s=[]){let a=!0,l="";if(e.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),r=i.notation;if(o.length>0&&!o.some((e=>r.toUpperCase()==e.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==o.length?"any notation":`notation${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{C:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(e,t){let n=e??o.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),u=s.notation;const d=r.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((e=>e!==u)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(r.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((e=>e!==u));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const e=v.value,i=e===l.Hi.SEPARATOR?y.value:void 0;await async function(e,t,n,i){const r=t.getSeqHandler(e).convert(n,i);e.dataFrame.columns.add(r);const s=await o.functions.call("Bio:detectMacromolecule",{col:r});return s&&(r.semType=s),await o.data.detectSemanticTypes(e.dataFrame),r}(n,t,e,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],c=null}))))}},536:(e,t,n)=>{"use strict";n.d(t,{Z:()=>r});var i=n(6956);class r{constructor(e){const t=e.split(i.xe).filter((e=>e));t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const r=i[t],o=e.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),e.push(n)})),e}}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},9099:(e,t,n)=>{"use strict";n.d(t,{f:()=>s});var i=n(536),r=n(6956),o=n(9034);class s{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(r.pk),n=t[0].split(r.xe);this.simplePolymers=n.map((e=>new o.d(e))),this.connectionList=new i.Z(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map((e=>e.monomers.length)).reduce(((e,t)=>e+t),0),t=Array.from({length:e},(()=>[]));return this.bondData.forEach((e=>{e.forEach((e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)}))})),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,i),t.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,i.push(r)})),t.push(i)})),t}}},9034:(e,t,n)=>{"use strict";n.d(t,{d:()=>r});var i=n(8438);class r{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],r=[];return t.forEach((e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter((e=>!!e)).map((e=>(0,i.D)(e)));n.push(...t),t.forEach(((e,t)=>r.push(t%3==1?"Branch":"Backbone")))}else n.push((0,i.D)(e)),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],r=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],r=i-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}},8604:(e,t,n)=>{"use strict";n.d(t,{Es:()=>r,G3:()=>s,gt:()=>o,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",r="System:AppData/Bio/monomer-sets/",o="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>M});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),h=n(966),u=n(4139),d=n(5072),p=n.n(d),m=n(7825),f=n.n(m),g=n(7659),y=n.n(g),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=C(),p()(x.A,E),x.A&&x.A.locals&&x.A.locals;var _=n(5605);async function M(e,t){return new Promise((async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=u.HX.pepsea.method,e.pepsea.gapOpen??=u.HX.pepsea.gapOpen,e.pepsea.gapExtend??=u.HX.pepsea.gapExtend;const h=e.col?.dataFrame??i.shell.t,d=e.col??h.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(e),void a(new l.Ap(o.divText(e)))}const p=o.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=o.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=o.p(`Kalign version: ${u.b9}`,"kalign-version"),g=o.input.float("Gap open",{value:e.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=o.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=o.inputs([g,y,m]),v=o.button("Alignment parameters",(()=>{b.hidden=!b.hidden,[g,y,m].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending 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i=n(4328),r=n(6077),o=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function h(e,t,n,h,u,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let r,a;i.isHelm()?r=t:(a=t.name,t.name=`__${a}`,r=i.convert(o.Hi.HELM),r.name=a,e.columns.add(r,!1));try{m=await n.helmToAtomicLevel(r,!0,!0,u)}finally{r!==t&&(e.columns.remove(r.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,r.C4)(e,t,u,d,p)}if(m.molCol){const r=(0,c.qj)(e,t.name);m.molCol.name=r,e.columns.add(m.molCol,!0),await(0,a.Qc)(t,m.molCol,u,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(h)),await i.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>o});var i=n(4328),r=n(6082);function o(){const e=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);return null===e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function 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A{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?o.Column.fromFloat32Array(n,e):e instanceof 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p=Object.entries(this._freqs).sort(((e,t)=>e[0]!==g._S&&t[0]!==g._S?t[1].value-e[1].value:e[0]===g._S&&t[0]===g._S?0:e[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((e-t)*l*s,u,a*l,n),u+=n}}render(e,t,n,i,r,o){for(const[s,a]of Object.entries(this._freqs))if(s!==g._S){const l=(0,u.zS)(s,5),c=a.bounds,h=c.left;let d=y.S$;o&&(d=o.getMonomerTextColor(r,s)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(h,c.top,c.width,c.height),e.fillStyle=d,e.textAlign="left",e.font=t;const p=e.measureText(l);e.setTransform(c.width/p.width,0,0,c.height/i,h,c.top),e.fillText(l,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol 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E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const _=new class{render=20};class M extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=C._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA,semType:o.SEMTYPE.MACROMOLECULE});const e=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],t=Object.values(o.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA,columnTypeFilter:"numerical"}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(d.fH)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(d.mH)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(d.lT)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,C.getMonomerLibHelper)().then((e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(E.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(C._package.logger)}static viewerCounter=-1;viewerId=++M.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const r=t>i;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,e.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(g._S)||e.getFreq(g._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new h.Subject;renderRequestSub;render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(u.gp.positionNames),t=this.seqCol.getTag(u.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(u.z1).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(u.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?g._S:i,o=this.positions[e],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),r=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===r?g._S:r,s=t.get(n);this.positions[e].getFreq(o).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const h=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=o.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,r,o,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=o[t],i=e.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const h=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],u=(l-s)*n*t+i*t/2,d=(r*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let e=r;e<=s;e++)this.positions[e].render(a,i,l,c,h,this.monomerLib)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[r.divText(`Position ${s.label}`)];if(this.valueAggrType===o.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=r.divV(t);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,r,o){const s=t.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(8115),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(5605);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}})).onCancel((()=>{f()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class S extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends r.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new _(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class _ extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new S(this.props.substructure,t,v._package.logger),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>E,j:()=>x});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(439),c=n(3599),h=n(5072),u=n.n(h),d=n(7825),p=n.n(d),m=n(7659),f=n.n(m),g=n(5056),y=n.n(g),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(5999),S={};function x(e,t,n){const o=i.div();o.classList.add("macromolecule-cell-comp-analysis-host");const l=e.cell.column.tags[a.gp.alphabet],h=l===a.YI.DNA||l===a.YI.RNA?c.o.NUCLEOTIDE:c.o.AA,u={},d=n.getSeqHandler(e.cell.column),p=e.cell.rowIndex,m=d.getSplitted(p);s().count(0).take(m.length).filter((e=>!m.isGap(e))).forEach((e=>{let t=m.getCanonical(e);h===c.o.NUCLEOTIDE&&d.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=u[t]||0;u[t]=n+1}));const f=E(u,h,t);return Array.from(f.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),o.appendChild(f),new r.Widget(o)}function E(e,t,n){let o=0,s=null;for(const t of Object.values(e))o+=t,s=null===s?t:Math.max(s,t);const a=s/o,c=Object.assign({},...Array.from(Object.entries(e)).sort(((e,t)=>t[1]-e[1])).map((([e,s])=>{const c=s/o,h=n.getWebEditorMonomer(t,e).backgroundcolor,u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/a+"px",u.style.backgroundColor=h,l._S===e&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=r.Color.toHtml(r.Color.lightGray));const d=l._S===e?"-":e,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),h}S.styleTagTransform=C(),S.setAttributes=y(),S.insert=f().bind(null,"head"),S.domAPI=p(),S.insertStyleElement=v(),u()(A.A,S),A.A&&A.A.locals&&A.A.locals},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use 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infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new D("Graph.".concat(t,": provided updater is not a function."));return r.attributes=i(r.attributes),this.emit("edgeAttributesUpdated",{key:r.key,type:"update",attributes:r.attributes}),this}}}],X=N,J=G,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var r=!1;for(var o in t)if(o!==i){var s=t[o];if(r=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&r)return s.key}}function ne(e,t,n,i){var r,o,s,a=!1;for(var l in t)if(l!==i){r=t[l];do{if(o=r.source,s=r.target,a=n(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected),e&&a)return r.key;r=r.next}while(void 0!==r)}}function ie(e,t){var n,i=Object.keys(e),r=i.length,o=0;return new N((function(){do{if(n)n=n.next;else{if(o>=r)return{done:!0};var s=i[o++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function re(e,t,n,i){var r=t[n];if(r){var o=r.source,s=r.target;return i(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected)&&e?r.key:void 0}}function oe(e,t,n,i){var r=t[n];if(r){var o=!1;do{if(o=i(r.key,r.attributes,r.source.key,r.target.key,r.source.attributes,r.target.attributes,r.undirected),e&&o)return r.key;r=r.next}while(void 0!==r)}}function se(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var r,o,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var h=o,u=h.key,d=h.attributes,p=h.source,m=h.target;if(l=i(u,d,p.key,m.key,p.attributes,m.attributes,o.undirected),e&&l)return u}}function le(e,t,n,i,r,o){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,r.in,o),e&&s))return s;if("in"!==i&&(s=a(e,r.out,o,i?void 0:r.key),e&&s))return s}if("directed"!==n&&(s=a(e,r.undirected,o),e&&s))return s}function ce(e,t,n,i,r,o,s){var a,l=n?oe:re;if("undirected"!==t){if(void 0!==r.in&&"out"!==i&&(a=l(e,r.in,o,s),e&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(e,r.out,o,s),e&&a))return a}if("directed"!==t&&void 0!==r.undirected&&(a=l(e,r.undirected,o,s),e&&a))return a}var he=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function ue(){this.A=null,this.B=null}function de(e,t,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var h=r(c.key,c.attributes);if(e&&h)return c.key}}}function pe(e,t,n,i,r){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,r);if("string"==typeof n)return de(e,null,i,i[n],r)}var o,s=new ue;if("undirected"!==t){if("out"!==n){if(o=de(e,null,i,i.in,r),e&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=de(e,s,i,i.out,r),e&&o)return o;s.wrap(i.out)}}if("directed"!==t&&(o=de(e,s,i,i.undirected,r),e&&o))return o}function me(e,t,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return e&&e.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function fe(e,t,n,i,r){for(var o,s,a,l,c,h,u,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(h=c.target,m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((h=c.target).key!==a&&(h=c.source),m=!0,u=r(s.key,h.key,s.attributes,h.attributes,c.key,c.attributes,c.undirected),e&&u)return c;c=c.next}while(c)}if(n&&!m&&(u=r(s.key,null,s.attributes,null,null,null,null),e&&u))return null}}function ge(e){if(!c(e))throw new D('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new D("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new D('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new D("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new D("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new D("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new D("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}ue.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},ue.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,r,o,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(o),h=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(o,'" not found.'));if(!h)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var u={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,r,l,h,a);e._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,h.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,h.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,u.key=r,e.emit("edgeAdded",u),r}function Ee(e,t,n,i,r,o,s,l,h){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(h){if("function"!=typeof l)throw new D("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new D("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var u;if(o=""+o,s=""+s,h&&(u=l,l=void 0),!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(o),f=e._nodes.get(s);if(!n&&(d=e._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(h?!u:!l)return g;if(h){var y=p.attributes;p.attributes=u(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},h&&u&&(l=u(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Se(e,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=Se(e,s,{}),w=!0),d=new z(i,r,m,f,l),e._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=r,e.emit("edgeAdded",b),[r,!0,v,w]}function _e(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,r=t.attributes,o=t.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),o?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:r,source:n.key,target:i.key,undirected:o})}var Me=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new D("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new D('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new D("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?U:"directed"===e.type?W:q;u(s(t),"NodeDataClass",i);var r="geid_"+ve()+"_",o=0;return u(s(t),"_attributes",{}),u(s(t),"_nodes",new Map),u(s(t),"_edges",new Map),u(s(t),"_directedSize",0),u(s(t),"_undirectedSize",0),u(s(t),"_directedSelfLoopCount",0),u(s(t),"_undirectedSelfLoopCount",0),u(s(t),"_edgeKeyGenerator",(function(){var e;do{e=r+o++}while(t._edges.has(e));return e})),u(s(t),"_options",e),Ce.forEach((function(e){return u(s(t),e,t[e])})),d(s(t),"order",(function(){return t._nodes.size})),d(s(t),"size",(function(){return t._edges.size})),d(s(t),"directedSize",(function(){return t._directedSize})),d(s(t),"undirectedSize",(function(){return t._undirectedSize})),d(s(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(s(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(s(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",(function(){return"graphology"})),t}t(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(e){return this._nodes.has(""+e)},r.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.out.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.undirected.hasOwnProperty(t)}throw new D("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new D("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},r.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},r.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},r.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},r.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},r.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},r.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},r.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},r.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},r.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},r.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},r.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},r.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},r.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},r.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},r.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},r.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},r.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},r.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},r.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},r.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},r.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},r.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(e===i)return r;if(e===r)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},r.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},r.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},r.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},r.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new D('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},r.mergeNode=function(e,t){if(t&&!c(t))throw new D('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},r.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new D('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var r=t?t({}):{};return n=new this.NodeDataClass(e,r),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:r}),[e,!0]},r.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{_e(this,t),t=t.next}while(t)}for(var r in n.in){t=n.in[r];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},r.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},r.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(e){return this._attributes[e]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},r.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.updateAttribute=function(e,t){if("function"!=typeof t)throw new D("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},r.replaceAttributes=function(e){if(!c(e))throw new D("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(e){if(!c(e))throw new D("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},r.updateAttributes=function(e){if("function"!=typeof e)throw new D("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},r.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new D("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new D("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=e(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},r.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},r.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},r.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new D("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(e){if("function"!=typeof e)throw new D("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},r.findNode=function(e){if("function"!=typeof e)throw new D("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},r.mapNodes=function(e){if("function"!=typeof e)throw new D("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(t=i.next()).done;)n=t.value,r[o++]=e(n.key,n.attributes);return r},r.someNode=function(e){if("function"!=typeof e)throw new D("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},r.everyNode=function(e){if("function"!=typeof e)throw new D("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},r.filterNodes=function(e){if("function"!=typeof e)throw new D("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),r=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(e,t){if("function"!=typeof e)throw new D("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new D("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=t,o=this._nodes.values();!0!==(n=o.next()).done;)r=e(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return h(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,r){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return h(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,r,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},r.import=function(e){var t,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new D("Graph.import: invalid argument. 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applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}const R=rxjs.operators;var O=n(6295);const k=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,i)}class F{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||o.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const h=c/this._workerCount,u=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*h),g=n===this._workerCount-1?c:Math.floor((n+1)*h),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(u.set(o,i),s<m&&(m=s),a>f&&(f=a),e())}}))}await Promise.all(l),n&&u.forEach(((e,t)=>{u[t]=(e-m)/(f-m)})),i(u)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class H{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}static pruneSparseMatrix(e,t=1e6){const n=200,i=new Uint32Array(n),r=e.distance.length,o=e.distance;for(let e=0;e<r;e++)i[Math.floor(o[e]*n)]++;let s=0,a=0;for(let e=0;e<n&&(s+=i[e],a=e,!(s>=t));e++);const l=new Uint32Array(s),c=new Uint32Array(s),h=new Float32Array(s),u=e.i,d=e.j;let p=0;const m=(a+1)/n;for(let e=0;e<r;e++)o[e]<m&&(l[p]=u[e],c[p]=d[e],h[p]=o[e],p++);return{i:l,j:c,distance:h}}async calcMultiColumn(e,t,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,o,s,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),o.forEach(((e,t)=>o[t].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,h)=>{const u=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=u&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:u,endIdx:p,threshold:r,fnNames:t,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:o}})=>{e?(d[n].terminate(),h(e)):(d[n].terminate(),i({i:t,j:r,distance:o,idx:n}))}}));const p=await Promise.all(u),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,r=.8,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,threshold:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnSingleValueKNN(e,t,r,o=15,s,a,l=i.EUCLIDEAN){if(e.length!==r.length||e.length!==s.length||e.length!==a.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(810),n.b)))),h=new Array(this._workerCount),u=e[0].length,d=e.map((e=>e[t])),p=Math.ceil(u/this._workerCount);for(let t=0;t<this._workerCount;t++)h[t]=new Promise(((n,i)=>{const h=t*p,m=t===this._workerCount-1?u:(t+1)*p;m<=h&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),c[t].postMessage({values:e.map((e=>e.slice(h,m))),target:d,fnNames:r,opts:s,nNeighbours:o,weights:a,aggregationMethod:l,startIdx:h}),c[t].onmessage=({data:{error:e,knnDistances:r,knnIndexes:o}})=>{e?(c[t].terminate(),i(e)):(c[t].terminate(),n({knnDistances:r,knnIndexes:o}))}}));const m=await Promise.all(h),f={knnDistances:new Array(o).fill(99999),knnIndexes:new Array(o).fill(-1)};for(const e of m)for(let t=0;t<(e.knnDistances?.length??0);++t)G(f.knnDistances,f.knnIndexes,e.knnDistances[t],e.knnIndexes[t]);return f}async multiColumnKNN(e,t,r=15,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,h)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),u[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[n].terminate(),h(e)):(u[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:h,fnNames:t,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}}));const d=await Promise.all(u),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of d)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,o=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=i&&(r.push(l),o.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,D,V=n(8774);(D=B||(B={})).none="none",D.bold="bold",D.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new h.Subject,this.lineHover=new h.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,r,o,s,a,l,c,h,u,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.pointToScreen(this.lines.from[e]);let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.pointToScreen(this.lines.to[e]);let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(r=this.lines.colors)||void 0===r?void 0:r[e])?null===(o=this.lines.colors)||void 0===o?void 0:o[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(h=this.lines.widths)||void 0===h?void 0:h[e])?null===(u=this.lines.widths)||void 0===u?void 0:u[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const r=this.getPointOnDistance(w,C,S,x,i,t),o=this.getPointOnDistance(S,x,w,C,n,t);w=r.x,C=r.y,S=o.x,x=o.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,r=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:w,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:C,n,r)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case B.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,r=null;const o=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(o.get(this.lines.from[s])&&o.get(this.lines.to[s])&&this.visibility.getBit(s)){const o=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),h=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,o,n),u=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,h.x,h.y,s):this.findControlPoint(this.multipleLinesCounts[s],h.x,h.y,i.x,i.y,s);r=this.calculateDistToCurveLine(s,e,t,i,h,u)}else r=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=r-2&&e<=o+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const r=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,h=c-l;return this.calculateDistToCurveInRect(t,n,i,o,r,e,h)}return null}calculateDistToCurveInRect(e,t,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!d||d>g)&&(d=g),u[o]=Math.max(m,f),c[o]=a,h[o]=p}for(let e=0;e<c.length;e++)u[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,h[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,r,o){const s=n-r*((n-e)/o),l=i-r*((i-t)/o);return new a.Point(s,l)}findControlPoint(e,t,n,i,r,o){const s=t+(i-t)/2,l=n+(r-n)/2;let c=s-t,h=l-n;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*h,l-d/2*c):new a.Point(s-d/2*h,l+d/2*c)}canvasArrow(e,t,n,i,r){const o=Math.atan2(i-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}var U,W,q=n(8060),z=n(3629);async function Y(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(n.p+n.u(234),n.b));u.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(q.S).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),e?h(e):c(t),setTimeout((()=>u.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,r,s,a,l);return c=c.map((e=>(0,z.S8)(e))),c}(W=U||(U={})).EUCLIDEAN="EUCLIDEAN",W.MANHATTAN="MANHATTAN";const K={[U.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[U.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.VECTOR_COSINE="Vector Cosine",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) 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(var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n 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a=Object.values(Z);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(U).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(o.length!==e.length||o.length!==n.length||o.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,h=e[0].length,u=e.map(((e,t)=>function(e,t=Z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,o;let s=null;const a=e.some((e=>"string"==typeof e))?(s="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(s="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(s="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(s="FLOAT32ARRAY",e):e.some((e=>e instanceof 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Float32Array([i.range]),m=`\n range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${h}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:h,arraySizes:c,complexity:u,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,o[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=U.MANHATTAN);let d=u.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=u.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*h);u.forEach(((e,t)=>{f.set(e.arraySizes,t*h)}));const g=1e4,y=100,b=u.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=h*(h-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${h}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${h}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${h}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${h}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${ne(n,u.map((e=>e.maxEntryLen)),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),$=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=h-2-Math.floor(Math.sqrt(-8*t+4*h*(h-1)-7)/2-.5),i=t-h*n+Math.floor((n+1)*(n+2)/2);T[e]=O,L[e]=R,N[e]=i,$[e]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+h*c+c+u.reduce(((e,t)=>e+t.sourceArraySize),0),G=u.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,H=k*Uint32Array.BYTES_PER_ELEMENT;let B=H;const D=15&H;0!==D&&(B+=16-D);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let W=0;new Uint32Array(j,W,g).set(T),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(L),W+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,W,g).set(N),W+=g*Uint32Array.BYTES_PER_ELEMENT,new 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t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}($.saliVals),G=.8/(k.max-k.min),F=o.shell.getTableView(e.name),D=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:P.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(e,t,n,i,r,o,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const h=a.DataFrame.create(c.from.length);return de.forEach(((e,t)=>{h.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(h.col(e),o),h.col(e).semType=r})),h.columns.addNewFloat(le).init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),h.columns.addNewInt(ue).init((e=>e)),h.columns.addNewFloat(ce).init((e=>t.saliVals[e])),h.columns.addNewFloat(he).init((e=>t.simVals[e])),h.name=`${se}${oe}`,{lines:c,linesDf:h}}(e,$,t,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ce).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const W=new j(D,i[0],i[1],V.lines,B.none),q=b?b(V.linesDf,de).sort([ce],[!1]):V.linesDf.plot.grid().sort([ce],[!1]);q.col(ue)&&(q.col(ue).visible=!1),e.temp[".cliffsDfGrid"]=q;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{const e=re()(F.viewers).some((e=>e.dataFrame.name===`${se}${oe}`));w&&!e&&F.addViewer(q),F.dockManager.dock(q,"down",null,"Activity 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n=V.linesDf.currentCol&&V.linesDf.currentCol.name===de[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(D.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;W.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:h,zoomBottom:u}=function(e,t,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=e/s,c=t/a,h=Math.min(l,c),u=e/h*5,d=t/h*5,p=(n<r?n:r)+s/2-u/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+u,zoomTop:m,zoomBottom:m-d}}(D.viewport.width,D.viewport.height,D.dataFrame.get(i[0],V.lines.from[n]),D.dataFrame.get(i[1],V.lines.from[n]),D.dataFrame.get(i[0],V.lines.to[n]),D.dataFrame.get(i[1],V.lines.to[n]));D.zoom(a,h,c,u),K.value?e.filter.and(O):!0===K.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,r,a,l,c,h){const u=t.getPane("Cliff Details");s.empty(u.root);const d=h({points:[n,i],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});u.root.append(d),setTimeout((()=>{o.shell.o=t.root}),500)}(e,A,V.lines.from[r],V.lines.to[r],r,t,l,V.linesDf.get(ce,r),y);const n=D.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(t.name,n.indexOf(D.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<V.linesDf.rowCount;e++){const n=V.linesDf.selection.get(e);n&&(t.set(V.lines.from[e],!0),t.set(V.lines.to[e],!0)),V.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),W.linesToRender=V.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<V.lines.colors.length;e++)V.lines.colors[e]="0,128,0";W.linesToRender=V.lines})(q.dataFrame))})),W.lineClicked.subscribe((t=>{if(S=!0,W.currentLineId=t.id,-1!==t.id){const 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fe,ge=n(2003),ye=n(3516),be=n(6718),ve=n(3077),we=n(439);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(fe||(fe={}));var Ce=n(9192);class Ae{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Se extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ae}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var xe,Ee,_e,Me=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function Ie(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function Te(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(xe||(xe={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(Ee||(Ee={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(_e||(_e={})),Object.prototype.toString;var Le=n(6873),Ne=n(4356),$e=n(6717),Pe=n(4870),Re=n(3856),Oe=n(6882),ke=n(7278),Ge=n(5553),Fe=n(6642),He=n(3599),Be=n(673),De=n(8312);class Ve extends Fe.sD{monomerLib=null;seqHelper=null;constructor(e,t){super(e,t,Bi.logger),(0,be.pj)().then((e=>{this.monomerLib=e.getMonomerLib(),this.dirty=!0,this.gridCol?.grid?.invalidate(),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))})),(0,De.Q)().then((e=>{this.seqHelper=e,this.dirty=!0,this.gridCol?.grid?.invalidate()}))}}var je=n(4139);const Ue=ge.zS;function We(e){const t=!re().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,r]of re().enumerate(e)){let o=t;r<e.length&&(o+=`${t?"":"-"}${i}`),n.push(o)}return[n,t]}class qe extends a.GridCellRenderer{seqHelper;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}hasMouseOver=!1;constructor(){super(),this.seqHelper=Bi.seqHelper}getRendererBack(e){const[t,n,i]=(0,Fe.BG)(e);if(n.meta.units!==ge.Hi.CUSTOM)return i.rendererBack;let r=null;return this.seqHelper&&(r=this.seqHelper.getSeqHandler(n).getRendererBack(t,n)),r}onClick(e,t){if(e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate(),e.cell.column.meta.units===ge.Hi.CUSTOM){const n=this.getRendererBack(e);n?.onClick(e,t)}}onMouseEnter(e,t){const n=this.getRendererBack(e);n?.onMouseEnter(e,t),this.hasMouseOver=!0}onMouseMove(e,t){const n=this.getRendererBack(e);n?.onMouseMove(e,t)}onMouseLeave(e,t){if((0,Ge.WN)(e,null),e?.grid){const t=e.grid.onEvent("d4-grid-show-tooltip").subscribe((e=>{t.unsubscribe(),this.hasMouseOver&&e.preventDefault()}))}this.hasMouseOver=!1}onDoubleClick(e,t){const n=this.getRendererBack(e);n?.onDoubleClick(e,t)}onKeyDown(e,t){const n=this.getRendererBack(e);n?.onKeyDown(e,t)}onKeyPress(e,t){const n=this.getRendererBack(e);n?.onKeyPress(e,t)}renderInt(e,t,n,i,r,o,s){const[a,l,c]=(0,Fe.BG)(o);if(!l)return;const h=l.temp,u=this.seqHelper.getSeqHandler(l);let d=(Bi.properties?Bi.properties.maxMonomerLength:4)??50;if(Re.gp.maxMonomerLength in l.tags){const e=parseInt(l.getTag(Re.gp.maxMonomerLength));d=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];d=!isNaN(e)&&e?e:50}let p=c.rendererBack;p||(p=c.rendererBack=new Oe.Jy(a,l,Bi.logger,d,(()=>{const{font:e,fontWidth:t}=Oe.Jy.getFontSettings(l);return{font:e,fontCharWidth:t,separatorWidth:u.isMsa()?8:0,monomerToShort:Ue}})),l.temp[".mm.cellRenderer.settingsChanged"],Be.s.true,p.init().then((()=>{}))),p.render(e,t,n,i,r,o,s)}render(e,t,n,i,r,o,s){if(o.cell.column?.meta?.units!==ge.Hi.CUSTOM)this.renderInt(e,t,n,i,r,o,s);else{const a=this.getRendererBack(o);a?.render(e,t,n,i,r,o,s)}}}class ze extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell.value??"",h=this.tableCol.tags[ge.gp.separator],u=this.tableCol.meta.units;i=(0,Oe.U0)(l,e,t,i,a);const[d,p]=c.split("#"),m=(0,ke.Iv)(u,h),f=m(d),g=m(p),y=re().count(0).take(f.length).map((e=>f.getCanonical(e))).toArray(),b=re().count(0).take(g.length).map((e=>g.getCanonical(e))).toArray(),v=this.tableCol.getTag(ge.gp.alphabet);Ke(e,t,n,i,r,y,b,v===ge.YI.RNA||v===ge.YI.DNA?He.o.NUCLEOTIDE:He.o.AA,this.monomerLib,void 0,void 0)}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let r=i.rendererBack;return r||(r=i.rendererBack=new ze(t,n)),r}}class Ye extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return je.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,r,o,s){ze.getOrCreate(o).render(e,t,n,i,r,o,s)}}function Ke(e,t,n,i,r,o,s,a,l,c,h){if(o.length!==s.length){const e=function(e,t){let n=0,i=0;const r=e.length>t.length?e:t,o=e.length>t.length?t:e;for(let e=0;e<o.length;e++)r[e]===o[e]&&n++;const s=r.length-o.length;for(let e=r.length-1;e>s;e--)r[e]===o[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(we.b9[ge.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(re()(t).toArray()):e=l(re()(e).toArray()),{subParts1:e,subParts2:t}}(o,s);o=e.subParts1,s=e.subParts2}const u=e.measureText(We(o).join("")),d=e.measureText(We(s).join("")),p=Math.max(u.width,d.width);c&&(i=p+4*o.length,e.canvas.width=p+4*o.length);let m=Math.max(t,t+(i-(p+4*o.length))/2)+5;const f=Math.max(n,n+(r-28)/2);e.save();try{e.beginPath(),e.rect(t,n,c?p+4*o.length:i,r),e.clip(),e.font="12px monospace",e.textBaseline="top";const u=7;for(let t=0;t<o.length;t++){const n=o[t],c=s[t];let d=Oe.S$;if(l&&(d=l.getMonomerTextColor(a,n)),n!=c){let o=Oe.S$;l&&(o=l.getMonomerTextColor(a,c));const s=(0,Re.oZ)(e,n,m,f-u,i,r,{color:d,pivot:0,left:!0}),p=(0,Re.oZ)(e,c,m,f+u,i,r,{color:o,pivot:0,left:!0});m=Math.max(p,s),h&&(h[t]=Ze(n,c,d,o,f,u,r))}else m=(0,Re.oZ)(e,n,m,f,i,r,{color:d,pivot:0,left:!0,transparencyRate:.5});m+=4}}finally{e.restore()}}function Ze(e,t,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(We([e]).join("")).width,h=l.measureText(We([t]).join("")).width,u=Math.max(c,h);return a.height=s,a.width=u+4,l.font="12px monospace",l.textBaseline="top",(0,Re.oZ)(l,e,0,r-o,u,s,{color:n,pivot:0,left:!0}),(0,Re.oZ)(l,t,0,r+o,u,s,{color:i,pivot:0,left:!0}),a}var Xe,Je=n(8070),Qe=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Xe||(Xe={}));const et=new class{constructor(){this.regionTypes=[Xe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Qe.fH.Entropy,this.filterSource=Qe.Fo.filterSource}};var tt=n(7602),nt=n(8047);const it=Xe;var rt,ot;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(rt||(rt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ot||(ot={}));const st=et;class at extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(ot.skipEmptyPositions,st.skipEmptyPositions,{category:rt.DATA}),this.regionTypes=this.stringList(ot.regionTypes,st.regionTypes,{category:rt.DATA,choices:Object.values(it).filter((e=>e!=it.Unknown))}),this.chains=this.stringList(ot.chains,st.chains,{category:rt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(ot.fitWidth,st.fitWidth,{category:rt.LAYOUT}),this.positionWidth=this.float(ot.positionWidth,st.positionWidth,{category:rt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(ot.positionHeight,st.positionHeight,{category:rt.LAYOUT,choices:Object.keys(Qe.fH)}),this.filterSource=this.string(ot.filterSource,st.filterSource,{category:rt.BEHAVIOR,choices:Object.values(Qe.lT)}),this.viewSyncer=new tt.g(Bi.logger)}static viewerCounter=-1;viewerId=++at.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,h.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case ot.regionTypes:case ot.chains:this.setData(this.regions)}switch(e.name){case ot.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case ot.fitWidth:case ot.positionWidth:this.calcSize();break;case ot.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionHeight]:this.positionHeight});this.calcSize();break;case ot.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;Bi.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){Bi.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){Bi.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const o=t.find((t=>t.order==n[e]&&t.chain==r));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(Qe.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Bi.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Bi.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,r=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[nt.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[nt.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(ot.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[nt.n5.filterSource]:this.filterSource})}}}))}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,Je.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}var lt=n(6625),ct=n(6863);async function ht(e,t,n="Morgan"){const i=e.length,r=Bi.seqHelper.getSeqHandler(e),o=Array(i);let s=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<i;t++){if(null===l[c[t]]||e.isNone(t)){o[t]=null;continue}o[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[t]+=a.get(i)}}let h={};if(t===ct.Z.MONOMER_CHEMICAL_DISTANCE||t===ct.Z.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,be.A7)(e,n),i={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{i[a.get(e)]=t}));const r=o.reduce(((e,t)=>Math.max(e,t.length)),0);h={scoringMatrix:t.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:h}}var ut=n(8115);function dt(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))})),t}function pt(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},r=Bi.seqHelper.getSeqHandler(e.seqCol),o=r.defaultBiotype,a=ft(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),o,i);return t.append(s.div(a,{style:{width:"300px",overflow:"scroll"}})),t.append(gt(i)),t.append(mt("Activity delta",Math.abs(n[0]-n[1]))),t.append(mt("Cliff",e.sali)),t}function mt(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function ft(e,t,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");r.height=30;const s=Bi.monomerLib;return Ke(o,0,0,0,30,re().count(0).take(e.length).map((t=>e.getCanonical(t))).toArray(),re().count(0).take(t.length).map((e=>t.getCanonical(e))).toArray(),n,s,!0,i),r}function gt(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function yt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ge.gp.separator,e.col(t[0]).getTag(ge.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class bt extends a.JsViewer{constructor(e,t){super(),this.name="",this.semType="",this.initialized=!1,this.gridSelect=!1,this.maxLimit=100,this.recomputeOnCurrentRowChange=!0,this.skipRecomputingProperies=[],this.debounceTimer=null,this.computeRequested=!1,this.renderPromise=Promise.resolve(),this.limit=this.int("limit",10,{min:1,max:this.maxLimit}),this.targetColumnName=this.string("targetColumnName",null,{...t?{semType:t}:{}}),this.name=e,this.semType=t}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>{this.gridSelect||this.render(e)}))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.targetColumnName??(this.targetColumnName=this.dataFrame.columns.bySemType(this.semType).name),this.targetColumn=this.dataFrame.col(this.targetColumnName),this.getProperty("limit").fromOptions({min:1,max:this.maxLimit})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("targetColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===this.semType&&(this.targetColumn=t)}this.debouncedRender()}}debouncedRender(e=!0){this.debounceTimer&&clearTimeout(this.debounceTimer),this.debounceTimer=setTimeout((()=>{this.render(e),this.debounceTimer=null}),100)}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.targetColumnName&&this.dataFrame.col(this.targetColumnName).semType!==this.semType&&(o.shell.error(`${this.targetColumnName} is not ${this.semType} type`),1))}}class vt extends bt{distanceMetric;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];tags=[a.TAGS.UNITS,ge.gp.aligned,ge.gp.separator,ge.gp.alphabet,"cell.renderer"];preComputeDistanceMatrix=!1;constructor(e,t){super(e,t),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS})}async onTableAttached(){super.onTableAttached(),this.dataFrame&&(this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3)}}const wt={gapPenalty:1,matchScore:1,gapSymbol:we.b9[we.Hi.FASTA],localAlignment:!1};class Ct extends vt{seqHelper;cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new h.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;analysisGrid;subInited=!1;constructor(e,t){super("similarity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=t}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.targetColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=(this.dataFrame.currentRowIdx??-1)<0?0:this.dataFrame.currentRowIdx,await this.computeByMM();const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.targetColumn})`;this.molCol=a.Column.string(e,this.idxs.length).init((e=>this.targetColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.targetColumn.getTag(e))));const t=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);await t.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(t),this.molCol.temp["reference-sequence"]=this.targetColumn.get(this.targetMoleculeIdx),this.molCol.temp[".mm.cellRenderer.maxMonomerLength"]=4;let n=null;t.onCurrentRowChanged.subscribe((e=>{n&&clearTimeout(n),this.dataFrame.currentRowIdx=t.col("indexes").get(t.currentRowIdx),n=setTimeout((()=>{this.createPropertyPanel(t)}),300),this.gridSelect=!0})),this.analysisGrid?(this.analysisGrid.dataFrame=t,this.analysisGrid.invalidate()):(this.analysisGrid=t.plot.grid(),(0,Pe.Ku)(this.root,this.analysisGrid.root)),this.analysisGrid.col("indexes").visible=!1,(0,Pe.Kd)(this.analysisGrid,this.molCol.name,450,30,!0);const i=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));this.analysisGrid.cell("score",i).cell.value=null;const r=o.shell.tv;this.subInited||(r.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),this.subInited=!0),this.computeCompleted.next(!0)}}async computeByMM(){const e=this.targetColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await ht(this.targetColumn,ct.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new H).getKNN(n,ct.Z.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,r=e.col(i),a=this.seqHelper.getSeqHandler(this.targetColumn),l=this.seqHelper.getSeqHandler(r),c=a.getSplitted(this.targetMoleculeIdx),h=l.getSplitted(e.currentRowIdx),u=function(e,t,n={}){const i={...wt,...n},r=e.length,o=t.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,h=i.localAlignment?l[1]:o,u=new Array(0),d=new Array(0);for(;c>0&&h>0;){const n=Math.max(s[c-1][h-1],s[c-1][h],s[c][h-1]);s[c][h]==s[c-1][h-1]+i.matchScore&&n==s[c-1][h-1]?(u.push(e.getCanonical(c-1)),d.push(t.getCanonical(h-1)),c-=1,h-=1):s[c][h]==s[c-1][h]-i.gapPenalty?(d.push(i.gapSymbol),u.push(e.getCanonical(c-1)),c-=1):s[c][h]==s[c][h-1]-i.gapPenalty?(u.push(i.gapSymbol),d.push(t.getCanonical(h-1)),h-=1):(u.push(e.getCanonical(c-1)),d.push(t.getCanonical(h-1)),c-=1,h-=1)}u=[...re().count(0).take(c).map((t=>e.getCanonical(t))),...u.reverse(),...i.localAlignment?re().count(l[0]).take(r).map((t=>e.getCanonical(t))):[]],d=[...re().count(0).take(h).map((e=>t.getCanonical(e))),...d.reverse(),...i.localAlignment?re().count(l[1]).take(o).map((e=>t.getCanonical(e))):[]];const p=c,m=h;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:u=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...u],d.length>u.length?u.push(...new Array(d.length-u.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(u.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:u.join(""),seq2:d.join(""),seq1Splitted:new ke.Mu(u,i.gapSymbol),seq2Splitted:new ke.Mu(d,i.gapSymbol)}}(c,h),d=ft(u.seq1Splitted,u.seq2Splitted,l.defaultBiotype,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==h.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${h.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(gt(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),o.shell.o=p.root}}var At=n(1407);class St extends vt{seqHelper;diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new h.Subject;constructor(e){super("diversity",a.SEMTYPE.MACROMOLECULE),this.seqHelper=e,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.targetColumn){const e=this.seqHelper.getSeqHandler(this.targetColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.targetColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.targetColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.targetColumn.getTag(e))));const i=a.DataFrame.fromColumns([n]);n.temp[".mm.cellRenderer.maxMonomerLength"]=4,i.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]}));const r=i.plot.grid();(0,Pe.Kd)(r,n.name,450,30),(0,Pe.Ku)(this.root,r.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,At.R)(this.targetColumn,this.seqHelper);a.DataFrame.fromColumns([e]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await ht(this.targetColumn,ct.Z.LEVENSHTEIN)).seqList,t=new F(!0,!1),n=await t.calc(e,ct.Z.LEVENSHTEIN);t.terminate();const i=this.targetColumn.length,r=(o=i,(e,t)=>o*e+t-Math.floor((e+2)*(e+1)/2));var o;this.renderMolIds=function(e,t,n){function i(e,t){let n=null,i=null;for(const r of e){const e=t(r);(null==i||e>i)&&(n=r,i=e)}return n}const r=[(s=e-1,Math.floor(function(e){return Math.random()*e}(s)))],o=new Set;var s;for(let t=0;t<e;++t)r.includes(t)||o.add(t);for(;r.length<t;){const e=i(o.values(),(e=>Math.min.apply(Math,r.map((function(t,i){return n(e,t)})))));null!=e&&(r.push(e),o.delete(e))}return r}(i,Math.min(i,this.limit),((e,t)=>this.targetColumn.isNone(e)||this.targetColumn.isNone(t)?0:n[r(e,t)]))}}var xt,Et=n(5433),_t=n(3890),Mt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(xt||(xt={}));class It{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[e,t,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Tt extends It{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Lt extends Tt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(xt.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(xt.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),r=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(xt.TYPE)&&-1!==e.indexOf(xt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,xt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<xt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,xt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,xt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+xt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=xt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends Tt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Lt(e);if($t.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Lt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Pt=n(6197),Rt=n(9124),Ot=n(3527);class kt{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",i=void 0,r=void 0,o=void 0,s){if(this.biotype=e,this.id=t,this.n=n,this.m=i,this.type=r,this.mt=o,this.smiles=s,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++kt.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Gt extends kt{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Ft extends kt{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Ht extends kt{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Bt extends kt{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class Dt{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,i,r,o,s,a){this.id=e,this.m=t,this.n=n,this.na=i,this.type=r,this.mt=o,this.at=s,this.smiles=a}static fromMonomer(e,t,n){let i={};const r=t.symbol,o=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{i[e.label]=e.capGroupName}));else{if(!o){if(t.lib)return new Bt(e,r);throw new Error("Unexpected missing monomer without .lib")}i=n.getRS(o)}const s=new Dt(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,i),a=n.getMonomerColors(e,t.symbol);return a&&(s.textcolor=a?.textcolor,s.linecolor=a?.linecolor,s.backgroundcolor=a?.backgroundcolor),s}}const Vt={[He.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[He.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[He.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[He.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[He.o.CHEM]:{R:"#eeeeee"},[He.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},jt=/[\w()]+/,Ut=RegExp(String.raw`\(${jt}(,${jt})+\)`),Wt=e=>{const t=s.canvas(250,250);return o.chem.canvasMol(0,0,250,250,t,e),t},qt=new Ot.Mi([255,255,255]),zt=new Ot.Mi([0,0,0]),Yt=.7*(0,z.wQ)(qt);class Kt{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new h.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length));for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t==we._S||t===we.b9[we.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:re().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{Bi.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}getWebEditorMonomer(e,t){const[n,i]=(0,Rt.fA)(e,t),r=(0,Pt.Y)(n);let o=this.getMonomer(r,i);if(o&&n==He.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==He.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(r,i));let s=o.wem??null;return s||(i===we._S||"*"==i?s=o.wem=new Gt(n):n===He.o.NUCLEOTIDE&&"N"===i||n===He.o.AA&&"X"===i||(He.o.CHEM,0)||Ut.test(i)?s=o.wem=new Ft(n,i):o.lib||(s=o.wem=new Ht(n,i,this.isEmpty)),s||(s=o.wem=Dt.fromMonomer(n,o,this))),s}getTooltip(e,t){const n=(0,Pt.Y)(e),i=s.div([],{classes:"ui-form ui-tooltip"}),r=this.getWebEditorMonomer(e,t),o=this.getMonomer(n,t);if(o){const e=o.symbol,[t,n,a]=(o.name,r?[r.textcolor,r.backgroundcolor,r.linecolor]:["#202020","#A0A0A0","#202020"]);let l;i.append(s.divH([s.div([e],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:t,backgroundColor:n,borderColor:a,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),s.div([o.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}})),l=o.molfile?Wt(o.molfile):o.smiles?s.divV([Wt(o.smiles),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),i.append(s.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),o.symbol!=we._S&&i.append(s.divText(o.lib?.source??"Missed in libraries"))}else i.append(s.divV([s.divText(`Monomer '${t}' of type '${n}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return i}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),i=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},r=i(n.textcolor),o=new Ot.Mi([...r.map((e=>e+1))]),s=(0,z.KE)(o,qt)/((0,z.wQ)(o)*(0,z.wQ)(qt)),l=i(n.backgroundcolor),c=new Ot.Mi([...l.map((e=>e+.01))]);let h;h=(0,z.KE)(c,qt)/((0,z.wQ)(c)*(0,z.wQ)(qt))<s?l:r;let u=new Ot.Mi(h);const d=(0,z.wQ)(u);return d>Yt&&(u=(0,z.dC)(zt,u,Yt/d)),`rgb(${u[0]}, ${u[1]}, ${u[2]})`}getMonomerColors(e,t){const n="default";let i=n;const r=(0,Pt.Y)(e),o=this.getMonomer(r,t);let s;if(o){if(o.meta&&o.meta.colors){const e=o.meta.colors;n in e||(i="default"),s=e[i]}if(!s){const t=Vt[e],n=t?.[o.symbol];n&&(s={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=o.naturalAnalog;if(!s&&t)return this.getMonomerColors(e,t)}return s||(s={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:s.text??s.textColor,linecolor:s.line??s.lineColor,backgroundcolor:s.background??s.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let i,r="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){i=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(r+=t[e][n]);n["R"+i]=r,r=""}return n}}var Zt=n(5488),Xt={};Xt.styleTagTransform=A(),Xt.setAttributes=b(),Xt.insert=g().bind(null,"head"),Xt.domAPI=m(),Xt.insertStyleElement=w(),d()(Zt.A,Xt),Zt.A&&Zt.A.locals&&Zt.A.locals;class Jt extends Kt{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?.[n]??null}else{Bi.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=(0,Pt.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=$t.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Ne.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const r=e.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((e=>e.lib?.source===r));o?this._monomers[n][i]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of re().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}static overrideCounter=0;override(e,t){return new Qt(e,`override: ${++Jt.overrideCounter}, ${t}`,this)}}class Qt extends Kt{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class en{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,r){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,Ce.AP)(e);this.error=t,this.monomers=[]}}}class tn{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nn=n(7433),rn=n.n(nn),on=n(1913),sn=n.n(on);class an{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(rn())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});sn()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const r of e){const e=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,r,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${e}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}var ln=n(8604);class cn{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();initializedPromise=Promise.resolve();constructor(e,t,n,i){let r;this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i;let o=!1;this.initializedPromise=Promise.race([a.delay(1e3),new Promise((e=>r=e))]),this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{})),o||(o=!0,r())})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++cn.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await o.dapi.files.readAsText(ln.gt),r=JSON.parse(i),s=new an(r);return new cn(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists(ln.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText(ln.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists(ln.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete(ln.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists(ln.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),r=await i.readAsText(t);n=JSON.parse(r);const o={},s=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(o[t]={},s.push(t)),o[t][n]=e})),new Jt(o,t)}async loadSetFromFile(e,t,n){let i={};const r=new a.FileSource(t),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,r=n.polymerType,o=n.monomerType,s=n.set;return new en(e,i,r,o,s)}));return new tn(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(ln.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),await this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${ln.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Bi.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Bi.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Bi.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText(ln.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Bi.logger.debug(`${e}, OUT`)})),Bi.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(ln.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ln.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(ln.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ln.Es.length)))}}class hn{constructor(){}static _instance;static getInstance(){return hn._instance||(hn._instance=new hn),hn._instance}_libFilesUpdateSubject$=new h.BehaviorSubject([]);_setFilesUpdateSubject$=new h.BehaviorSubject([]);_addLibraryFilesSubject$=new h.Subject;_librarySelectionSubject$=new h.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class un{logger;_monomerLib=new Jt({},"MAIN");_monomerSets=new tn("MAIN",[]);_initialLoadCompleted=!1;get initialLoadCompleted(){return this._initialLoadCompleted}_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Je.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++un.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return un.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>{const e=await cn.create(this,this._eventManager,this.logger);return await e.initializedPromise,e})()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Ne.ub)()]),r=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((e=>this.readLibrary(ln.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Jt({},e,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,e),this._initialLoadCompleted=!0}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((t=>this.readSet(ln.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tn("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const 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V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:bn};async function wn(e,t,n=0){if(!Object.keys(vn).includes(t))return null;const i=await async function(e){const t=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;const r=vn[t];let o=0,s=null;for(const[e,t]of Object.entries(r)){const r=(0,O.$1)(i,t);r>o&&r>=n&&(o=r,s=e)}return s}var Cn,An=n(857),Sn={};Sn.styleTagTransform=A(),Sn.setAttributes=b(),Sn.insert=g().bind(null,"head"),Sn.domAPI=m(),Sn.insertStyleElement=w(),d()(An.A,Sn),An.A&&An.A.locals&&An.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(Cn||(Cn={}));const xn={[Cn.MONOMER]:a.COLUMN_TYPE.STRING,[Cn.SYMBOL]:a.COLUMN_TYPE.STRING,[Cn.NAME]:a.COLUMN_TYPE.STRING,[Cn.R_GROUPS]:a.COLUMN_TYPE.STRING,[Cn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[Cn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[Cn.AUTHOR]:a.COLUMN_TYPE.STRING,[Cn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[Cn.ID]:a.COLUMN_TYPE.INT,[Cn.META]:a.COLUMN_TYPE.STRING,[Cn.SOURCE]:a.COLUMN_TYPE.STRING};class En{monomerLibManamger;adjustTable(){this.tv?.dataFrame&&(o.data.detectSemanticTypes(this.tv.dataFrame),this.tv.dataFrame.meta.detectSemanticTypes()),setTimeout((()=>{this.tv?.grid&&(this.tv.grid.props.allowEdit=!1,this.tv.grid.col(Cn.NAME).width=100,this.tv.grid.col(Cn.SYMBOL).width=70)}),200)}static VIEW_NAME="Manage Monomers";_newMonomer=gn.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new Ln(e,(()=>this.activeMonomerLib),(async e=>{const t=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=t,this.adjustTable(),null!=e&&setTimeout((()=>{const n=t.col(Cn.SYMBOL).toList().indexOf(e);-1!==n&&(this.tv?.grid.scrollToCell(t.columns.byIndex(0),n),t.currentRow=t.rows.get(n))}),500))}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new En(e)}return this.instance}static async getNewInstance(){const e=await un.getInstance();return await e.awaitLoaded(),await e.loadLibrariesPromise,new En(e)}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))),null,2);e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await o.dapi.files.writeAsText(ln.so+e,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(e)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)o.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e,t=!0){const n=await this.getMonomersDf(e);return this.tv=a.TableView.create(n,t),this.adjustTable(),this.tv.subs.push(o.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(()=>{this.cloneMonomer(this.tv.dataFrame.rows.get(t))})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>On(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>On(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(()=>{const e=On(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv.grid&&(this.tv.grid.props.allowEdit=!1),this.tv}static closeAllMonomerManagers(){Array.from(o.shell.tableViews??[]).filter((e=>e.name===En.VIEW_NAME)).forEach((e=>e.close()))}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e?o.shell.v=e:En.closeAllMonomerManagers(),e??null}_skipLibInputOnchange=!1;async getViewRoot(e,t=!0){const n=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),t&&(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){try{this._skipLibInputOnchange=!0,this.libInput&&(this.libInput.items=n),e&&(this.libInput.value=e)}catch(e){o.shell.error("Error updating library list"),console.error(e)}finally{this._skipLibInputOnchange=!1}const t=await this.getMonomersDf(e);return this.tv.dataFrame=t,this.adjustTable(),this.tv}e??=n[0],this.tv=await this.getMonomersTableView(e,t);let i=this.tv.getRibbonPanels();i.forEach(((e,t)=>{i[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),i=i.filter((e=>e.length>0));const r=s.icons.add((()=>{this._newMonomerForm.setEmptyMonomer()}),"Add New Monomer"),l=s.icons.edit((()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||this.cloneMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),c=s.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=t.map((e=>On(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=On(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(c,(()=>(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]).length>0?"Delete selected monomers":"Delete monomer"));const h=s.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{t=await o.dapi.files.readAsText(ln.so+e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");i.push([r,l,c,h]),this.tv.setRibbonPanels(i),this.tv.name=En.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:n,nullable:!1,onValueChanged:async()=>{try{if(this._skipLibInputOnchange)return;const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e,this.adjustTable()}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const u=this._newMonomerForm.form;return u.prepend(this.libInput.root),s.tools.waitForElementInDom(this.tv.root).then((()=>{this.tv.dockManager.dock(u,a.DOCK_TYPE.LEFT,null,void 0,.4)})),this.tv}cloneMonomer(e){return this._newMonomer=On(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary(ln.so,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),a.DataFrame.create();const t=this.activeMonomerLib.getPolymerTypes().flatMap((e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map((t=>this.activeMonomerLib.getMonomer(e,t))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const r=Array.from(i);r.sort();for(const[e,t]of Object.entries(xn))if(n.columns.addNew(e,t),e===Cn.R_GROUPS)for(const e of r)n.columns.addNew(e,a.COLUMN_TYPE.STRING);n.col(Cn.SYMBOL).semType="Monomer",n.col(Cn.SYMBOL).setTag(Re.Mn.applyToBackground,"true");for(let e=0;e<t.length;e++){let i=$n(t[e].rgroups,t[e].smiles,t[e].molfile);i=_n(i),t[e].rgroups=Tn(t[e].rgroups);const o=r.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?In(i,"capGroupSmiles"):""}));n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...o,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,t[e].createDate,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""])}return n.col(Cn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((e=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;this.cloneMonomer(n.rows.get(n.currentRowIdx))}catch(e){console.error(e)}})),n}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}resetCurrentRowFollowing(){this._newMonomerForm.molChanged=!1}}function _n(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const Mn=["alternateId","capGroupName","capGroupSMILES","label"];function In(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function Tn(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(Mn,e),n=In(t,"capGroupSMILES"),i=In(t,"alternateId"),r=In(t,"capGroupName"),o=In(t,"label")??"R1";if(n&&i&&r||o.length<2)return t;if(i&&-1!==i.indexOf(`${o}-`)){const e=i.replace(`${o}-`,"");r||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${o.substring(1)}][${e}]`)}else r&&(n||(t.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(t.alternateId=`${o}-${r}`));return t})).sort(((e,t)=>e.label?.localeCompare(t.label??"")??0))}class Ln{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;colors;colorsEditor;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}set molChanged(e){this._molChanged=e}saveValidationResult=null;triggerMolChange=!0;inputsTabControl;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.colors={line:"#000000",background:"#000000",text:"#000000"},this.colorsEditor=new kn(this.colors),this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));e&&e.header.style.removeProperty("background-color");let t=this.molSketcher.getSmiles();if(!t)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="Monomer molecule is required",void this.invalidateSaveButton();t=$n([],t);const n=this.findRgroupsInSmiles(t);if(0===n.length)return this.rgroupsGrid.items=[],this.rgroupsGrid.render(),this.saveValidationResult="At least one R-group is required",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();if(new Set(n.map((e=>e[0]))).size!==n.length)return this.saveValidationResult="Duplicate R-groups are not allowed",this.rgroupsGridRoot.style.display="flex",e&&e.header.style.setProperty("background-color","#ff000030"),void this.invalidateSaveButton();const i=n.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items=i.sort(((e,t)=>e.label?.localeCompare(t.label??"")??0)),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const r=await wn(Rn(t,i),this.polymerTypeInput.value??"");r&&(this.monomerNaturalAnalogInput.value=r)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new yn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new yn(l,[]),this.onMonomerInputChanged();const c=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]);this.inputsTabControl=s.tabControl({Monomer:c,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root]),Colors:this.colorsEditor.form},!1)}invalidateSaveButton(){this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled")}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.invalidateSaveButton();const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setEmptyMonomer(){this.triggerMolChange=!1,this.molSketcher.setSmiles(""),this.monomerSymbolInput.value="",this.monomerNameInput.value="",this.monomerIdInput.value=null,this.monomerNaturalAnalogInput.value=null,this.rgroupsGrid.items=[],this.metaGrid.items=[],this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="none",this.onMonomerInputChanged(),this.colorsEditor.colors={line:"#000000",background:"#000000",text:"#000000"}}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Tn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).filter((([e,t])=>"colors"!==e?.toLowerCase())).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),e.naturalAnalog||wn(Rn(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}));const t=e.meta?.colors??"";let n={};try{n=t?JSON.parse(t)?.default:{}}catch(e){console.error(e)}this.colorsEditor.colors={line:n.line??"#000000",background:n.background??"#000000",text:n.text??"#000000"}}validateInputs(){const e=this.inputsTabControl.panes.find((e=>"r-groups"===e.name?.toLowerCase()));if(e&&e.header.style.removeProperty("background-color"),!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;let t=null;if(this.rgroupsGrid.items.length<1&&(t="At least one R-group is required"),!t)e:for(const e of this.rgroupsGrid.items)for(const[n,i]of Object.entries(e))if(!i){t=`R-group ${n} field is required for ${e.label}`;break e}return!t&&this.rgroupsGrid.hasErrors()&&(t="R-group fields contain errors"),t?(e&&e.header.style.setProperty("background-color","#ff000030"),t):null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){this.inputsTabControl.root.classList.add("monomer-manager-form-tab-control"),this.inputsTabControl.header.style.marginBottom="10px";const e=s.buttonsInput([this.saveButton]);return s.tooltip.bind(e,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,this.inputsTabControl.root,e],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=$n(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await o.dapi.files.readAsText(ln.so+t);i=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const r=e.map((e=>Nn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=r.map((e=>i[e])),l=s.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,h=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,u=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(h)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await o.dapi.files.writeAsText(ln.so+t,JSON.stringify(i,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),u.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await o.dapi.files.readAsText(ln.so+t);n=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const i=Nn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),r=this.getMonomersDataFrame()?.col(Cn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{const i=n.findIndex((t=>t.symbol===e.symbol&&t.polymerType===e.polymerType));i>=0?n[i]={...e,lib:void 0,wem:void 0}:n.push({...e,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText(ln.so+t,JSON.stringify(n,null,2)),await(await un.getInstance()).loadLibraries(!0),await this.refreshTable(e.symbol),this._molChanged=!1,o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}this.onMonomerInputChanged()};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const e=On(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=$n([],e);let t=o.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=Pn(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i=this.metaGrid.addingItem;i&&i.Property&&i.Value&&(n[i.Property]=i.Value),"#000000"===this.colorsEditor.colors.line&&"#000000"===this.colorsEditor.colors.background&&"#000000"===this.colorsEditor.colors.text||(n.colors={default:this.colorsEditor.colors});const r={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},s=this.getMonomerLib()?.source;s?await this.addMonomerToLib(r,s):o.shell.warning("Monomer library source is not specified")}}function Nn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function $n(e,t,n){const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(r,e),r=_n(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function Pn(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")||e.includes("V3000"))),r=Number.parseInt(t[i].trim().split(" ")[0]),o={};for(let e=i+1;e<i+1+r;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const r=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(o[e-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[e-i]=s)}const s=Object.keys(o);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M RGP${s.length.toString().padStart(3," ")}${Object.entries(o).map((([e,t])=>`${e.toString().padStart(4," ")}${t.toString().padStart(4," ")}`)).join("")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return s.filter((e=>!!Number.parseInt(e))).map((e=>Number.parseInt(e)+i)).forEach((e=>{const n=t[e].split(" "),i=n.findIndex((e=>"R#"===e));if(-1!==i){for(let e=i+1;e<n.length;e++)n[e]&&1==n[e].length&&(Number.parseInt(n[e])??0)>0&&(n[e]="0");t[e]=n.join(" ")}})),t.join("\n")}function Rn(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=In(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}function On(e){const t=JSON.parse(e.get(Cn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e]));const n=e.get(Cn.MONOMER);if(!n)throw new Error("Monomer SMILES is empty");let i="";try{i=o.chem.convert(n,a.chem.Notation.Smiles,a.chem.Notation.MolBlock),i=Pn(i)}catch(e){o.shell.error(`Error converting SMILES to molfile, \n ${n}`),console.error(e)}return{symbol:e.get(Cn.SYMBOL),name:e.get(Cn.NAME),molfile:i,smiles:n,polymerType:e.get(Cn.POLYMER_TYPE),monomerType:e.get(Cn.MONOMER_TYPE),naturalAnalog:e.get(Cn.NATURAL_ANALOG),id:e.get(Cn.ID),rgroups:JSON.parse(e.get(Cn.R_GROUPS)??"[]"),meta:t,author:e.get(Cn.AUTHOR),createDate:e.get(Cn.CREATE_DATE)}}class kn{_colors;_colorInputs;constructor(e){this._colors=e,this._colorInputs={line:s.input.color("Line",{value:e.line,onValueChanged:e=>this._colors.line=e}),background:s.input.color("Background",{value:e.background,onValueChanged:e=>this._colors.background=e}),text:s.input.color("Text",{value:e.text,onValueChanged:e=>this._colors.text=e})}}get colors(){return this._colors}set colors(e){const t={line:a.Color.toHtml(a.Color.fromHtml(e.line??"#000000")),background:a.Color.toHtml(a.Color.fromHtml(e.background??"#000000")),text:a.Color.toHtml(a.Color.fromHtml(e.text??"#000000"))};this._colors=t;for(const e in this._colorInputs)this._colorInputs[e].value=t[e]}get colorsMetaFormat(){return{colors:{default:this._colors}}}get form(){return s.form(Object.values(this._colorInputs))}}class Gn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class Fn{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Gn(e)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,e),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),r.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Hn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Hn._instance||(Hn._instance=new Hn,await Hn._instance.refresh(),(await un.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Hn._instance.refresh()))),Hn._instance.refresh(),Hn._instance}async refresh(){this.settings=await(0,Ne.ub)();const e=await un.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new Fn(n,this.monomers[t][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,Ne.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),e.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Bn(){await Un.showDialog()}async function Dn(e=!0){return await Wn.showView(e)}class Vn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Vn.instancePromise&&(Vn.instancePromise=(async()=>{const e=new Vn,t=await(0,be.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Vn.instancePromise}static async reloadWidget(){const e=await Vn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,be.pj)()).eventManager.addLibraryFileRequested$.subscribe((()=>this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await jn.createControlsForm();return pn()(e).addClass("monomer-lib-controls-form"),setTimeout((()=>{e&&pn()(e)&&pn()(e).removeClass("ui-form-condensed")}),200),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class jn{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((([e,t])=>{this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Bi.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,be.pj)().then((e=>e.getFileManager())),await(0,Ne.ub)()]);return new jn(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.wideForm(e,void 0);return pn()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();pn()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;Bi.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=s.icons.edit((async()=>{o.shell.v=await(await En.getInstance()).getViewRoot(e)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${e}`),i.addOptions(a),i.addOptions(r),Bi.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Ne.Eu)(this.userLibSettings);const n=await(0,be.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class Un{constructor(){}static _instance;dialog;closeDialogSubject$=new h.Subject;static async showDialog(){Un._instance||(Un._instance=new Un,Un._instance.closeDialogSubject$.subscribe((()=>{Un._instance.dialog=void 0}))),Un._instance.dialog||(Un._instance.dialog=await Un._instance.getDialog()),Un._instance.dialog.show()}async getDialog(){const e=hn.getInstance(),t=(await Vn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});pn()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t);const i=n.onClose.subscribe((()=>{this.closeDialogSubject$.next(),i.unsubscribe()}));return n}}class Wn{constructor(){}static _instance;static viewName="Manage Monomer Libraries";_view;_duplicateManager;libManager;async getView(e=!0){const t=hn.getInstance(),n=(await Vn.getInstance()).widget,i=s.bigButton("Add",(()=>t.addLibraryFile()),"Upload new HELM monomer library"),r=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),l=s.splitH([s.divV([n.root,s.buttonsInput([i,r])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);return this._view=a.View.fromRoot(l),this._view.name=Wn.viewName,e&&o.shell.addView(this._view),s.tools.waitForElementInDom(l).then((()=>{setTimeout((()=>{const e=Array.from(l.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,r=.3*i;t.style.width=`${r}px`;const o=i-r;n.style.width=`${o}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((()=>{try{const e=Wn._instance;e&&e._view&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))})),this._view}static async showView(e=!0){return Wn._instance||(Wn._instance=new Wn),Wn._instance._duplicateManager||(Wn._instance._duplicateManager=await Hn.getInstance()),Wn._instance.libManager||(Wn._instance.libManager=await un.getInstance()),e&&Wn._instance._view&&Array.from(o.shell.views).find((e=>e.id&&e.id===Wn._instance._view.id))?(o.shell.v=Wn._instance._view,await Wn._instance._duplicateManager.refresh(),Wn._instance._view):(Wn.closeExistingViews(),Wn._instance.getView(e))}static closeExistingViews(){Array.from(o.shell.views).filter((e=>e.name===Wn.viewName)).forEach((e=>e.close()))}async mergeSelectedLibs(){const e="Library with this name already exists",t=await un.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=h(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=r.value;return e.endsWith(".json")||(e+=".json"),e}function h(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}r.addValidator(h),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(t,e,!1);const n=await(0,Ne.ub)();n.exclude=l,await(0,Ne.Eu)(n),await this.libManager.loadLibraries(!0),await Vn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var qn,zn=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};class Yn{_setBreadcrumbsInViewName(){var e,t;const n=["Home","Demo",...(null!==(e=this._path)&&void 0!==e?e:"").split("/")],i=s.breadcrumbs(n);if(i.onPathClick.subscribe((e=>zn(this,void 0,void 0,(function*(){const t=e[e.length-1];if(t===i.path[i.path.length-1])return;const n=o.shell.browsePanel.mainTree.getOrCreateGroup("Apps").getOrCreateGroup("Demo");n.currentItem="Demo"===t?n:n.items.find((e=>e.text===t))})))),o.shell.v){if(0!==i.path.length&&"Home"===i.path[0]){const e=s.iconFA("home",(()=>{o.shell.v.close(),o.shell.v=a.View.createByType(a.VIEW_TYPE.HOME)}));e.classList.add("demo-breadcrumbs-home-element"),i.root.firstElementChild.replaceWith(e)}const e=null===(t=o.shell.v.ribbonMenu.root.parentElement)||void 0===t?void 0:t.getElementsByClassName("d4-ribbon-name")[0];e&&(e.textContent="",e.appendChild(i.root))}}constructor(e,t,n=!1,i){var r,o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>zn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>zn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>zn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.DEMO_PATH="apps/Tutorials/Demo",this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._path=null!==(o=null==i?void 0:i.path)&&void 0!==o?o:"",this._progress.max=0,this._progress.value=1,Yn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1,this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_setViewParams(){var e;o.shell.v&&(o.shell.v.name=this.name,o.shell.v.path=`${this.DEMO_PATH}/${(null!==(e=this._path)&&void 0!==e?e:"").replaceAll(" ","-")}`,this._setBreadcrumbsInViewName())}_nextStep(){return zn(this,void 0,void 0,(function*(){var e,t;this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{this._setViewParams(),yield this._steps[this._currentStep].func(),this._setViewParams()}catch(e){console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,Je.cb)(c));const h=s.iconFA("check");if(i.replaceWith(h),h.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}o.shell.v instanceof a.TableView&&(yield o.data.detectSemanticTypes(o.shell.tv.dataFrame))}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return zn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return zn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),e.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return zn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return zn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Yn.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return zn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.v.name===this.name&&(o.shell.v.close(),this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,o.shell.dockManager.findNode(o.shell.browsePanel.root),this.name)),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Yn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(qn||(qn={}));var Kn=n(966),Zn=n(608),Xn=n(1619);class Jn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=re()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Bi.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case nt.n5.fixWidth:case nt.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Qn{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var ei=n(6869);new class{tooltipHandlerTemp="tooltip-handler.Monomer"};class ti extends Ve{constructor(e,t){super(e,t)}render(e,t,n,i,r,o,s){e.save();try{if(o.gridRow<0)return;const s=o.cell?.column&&"true"===o.cell.column.getTag(Re.Mn.applyToBackground);e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=o.cell.value;if(!a||a==we._S)return;let l=Oe.S$,c="rgb(255, 255, 255)";if(this.monomerLib){const e=this.tableCol.getTag(we.gp.alphabet),t=e===ge.YI.RNA||e===ge.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA;if(s){const e=this.monomerLib.getMonomerColors(t,a);l=e?.textcolor??l,c=e?.backgroundcolor??c}else l=this.monomerLib.getMonomerTextColor(t,a)}const h=Math.max(2,Math.floor(.15*i));s&&(e.fillStyle=c,e.fillRect(t,n,i,r)),e.fillStyle=l,e.fillText((0,ge.zS)(a,h),t+i/2,n+r/2,i)}finally{e.restore()}}onMouseMove(e,t){if(e.grid.dart!=this.gridCol?.grid.dart||e.gridColumn.dart!=this.gridCol?.dart||!e.tableColumn||!e.isTableCell)return!1;const n=e.tableColumn.getTag(we.gp.alphabet),i=e.cell.value,r=e.grid.canvas.getBoundingClientRect(),o=e.bounds.right+r.left-4,a=e.bounds.bottom+r.top-4;if(i==we._S)return s.tooltip.show(s.divText("gap"),o,a),!0;if(!this.monomerLib)return s.tooltip.show(s.divText("Monomer library is not available."),o,a),!0;const l=n===ge.YI.RNA||n===ge.YI.DNA?ei.o.NUCLEOTIDE:ei.o.AA,c=this.monomerLib.getTooltip(l,i);return s.tooltip.show(c,o,a),!0}async awaitRendered(e=1e4,t=`${e} timeout`){return Promise.resolve()}static getOrCreate(e){const[t,n,i]=(0,Fe.BG)(e);let r=i.rendererBack;return r||(r=i.rendererBack=new ti(t,n)),r}}class ni extends a.GridCellRenderer{get name(){return je.uF.MONOMER}get cellType(){return je.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,r,o,s){ti.getOrCreate(o).render(e,t,n,i,r,o,s)}onMouseMove(e,t){ti.getOrCreate(e).onMouseMove(e,t)}}class ii{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ri extends Map{_onPropertyChanged=new h.Subject;get onPropertyChanged(){return this._onPropertyChanged}get fontSize(){const e=super.get("FontSize");return e&&!isNaN(e)?Number.parseInt(e):12}set fontSize(e){super.set("FontSize",e),this._onPropertyChanged.next("FontSize")}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class oi extends a.Package{_properties;_seqHelper;get seqHelper(){if(!this._seqHelper)throw new Error("Package Bio .seqHelper is not initialized.");return this._seqHelper}_monomerLib;get monomerLib(){if(!this._monomerLib)throw new Error("Package Bio .monomerLib is not initialized.");return this._monomerLib}_monomerSets;get monomerSets(){if(!this._monomerSets)throw new Error("Package Bio .monomerSets is not initialized.");return this._monomerSets}_rdKitModule;get rdKitModule(){if(!this._rdKitModule)throw new Error("Package Bio .rdKitModule is not initialized.");return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ii(super.logger,e.debug)}completeInit(e,t,n,i){this._seqHelper=e,this._monomerLib=t,this._monomerSets=n,this._rdKitModule=i,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Ce.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var si=n(2174);class ai extends a.Widget{seqCol;seqHelper;viewed=!1;wlViewer=null;constructor(e,t){super(s.divV([])),this.seqCol=e,this.seqHelper=t}async init(){const e=this.seqHelper.getSeqHandler(this.seqCol),t=Bi.properties.tooltipWebLogo,n=this.seqCol.getTag(Qe.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function li(e,t,n,i){const r=Bi.seqHelper.getSeqHandler(e);let o=null,s=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(o=e),r.posList[e]==n&&(s=e);if(null===o&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(o,s,a)}const ci={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(ge.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class hi{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??ci;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(ge.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(ge.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Bi.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ui{call;seqHelper;inputs=new class{table;sequence;region;start;end;name};constructor(e,t){this.call=e,this.seqHelper=t;const n=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const i=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:i,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,n(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&this.seqHelper.getSeqHandler(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=this.seqHelper.getSeqHandler(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?this.seqHelper.getSeqHandler(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),i.options.add(r)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(ge.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const r=e.options[i],o=JSON.parse(r.value);o&&t===o.start&&n===o.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Bi.handleErrorUI(e)}))})).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=s.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Bi.handleErrorUI(e)}))}));return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var di=n(8754);async function pi(e,t,n,i,r){const o=await async function(e,t,n,i,r){const o=(0,ve.R)(t,r),s=r.getSeqHandler(t).getNewColumnFromList("ref",[n]),l=r.getSeqHandler(s).getSplitted(0),c=i===fe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):we._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===o[t]&&++l[n];l[n]/=e.length}return s}(l,o):i===fe.SIMILARITY?await async function(e,t,n){const i=t.columns.toList();return await(0,be.uL)(i,e,n)}(l,o,r):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,i,r);for(let e=0;e<o.length;e++)t.isNone(e)&&o.set(e,null,!1);return o}var mi=n(294),fi=n(330);const gi=OCL;var yi=n(9099);class bi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var vi=n(6956);class wi{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===vi.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Ci{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,r=n*Math.cos(e)-i*Math.sin(e),o=n*Math.sin(e)+i*Math.cos(e);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:o}}))}}class Ai extends Ci{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Si{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class xi extends Si{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Ei extends bi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Ai(n),this.bonds=new xi(n),this.rGroups=new wi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class _i extends Ci{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,r,a)=>t+o+i+s+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Mi extends Si{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,r,o,s)=>`${n}${t[0]}${r}${t[1]}${s}`))}))}}class Ii extends bi{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new _i(n),this.bonds=new Mi(n),this.rGroups=new wi(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ti{static getInstance(e,t){if($t.isMolfileV2K(e))return new Ei(e,t);if($t.isMolfileV3K(e))return new Ii(e,t);throw new Error("Unsupported molfile version")}}class Li{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];static molfileV2KToV3KCache=new Map;constructor(e,t,n,i,r,o){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=Ti.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),this.removeRGroups(n.bondedRGroupsMap[t]),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){if(Li.molfileV2KToV3KCache.has(e))return Li.molfileV2KToV3KCache.get(e);let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i){const t=i.get_v3Kmolblock();return Li.molfileV2KToV3KCache.set(e,t),t}throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ni{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new yi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){if(e===we.b9[ge.Hi.HELM])return;const i=this.monomerWrappers.length,r=new Li(e,i,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(r)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new mi.Cg;for(const[n,r]of re().enumerate(this.monomerWrappers)){const o=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines());const a="RNA"==this.helm.getPolymerTypeByMonomerIdx(r)?He.o.NUCLEOTIDE:He.o.AA;i.set(r,{biotype:a,symbol:n.monomerSymbol,atoms:re().count(o).take(n.atomCount).toArray(),bonds:re().count(s).take(n.bondCount).toArray()})}const r=e.length,o=t.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END BOND"].join("\n")}}class $i{constructor(e){this.molfileHandler=$t.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Pi{helmHelper;rdKitModule;monomerLib;constructor(e,t,n){this.helmHelper=e,this.rdKitModule=t,this.monomerLib=n}convertToSmiles(e){const t=e.dataFrame,n=this.getSmilesList(e),i=`smiles(${e.name})`,r=t?t.columns.getUnusedName(i):i;return a.Column.fromStrings(r,n.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}molV3KtoMolV3KOCL(e){try{if(!e)return"";return gi.Molecule.fromMolfile(e).toMolfileV3().replace("STERAC1","STEABS")}catch(e){const[t,n]=(0,Ce.AP)(e);return Bi.logger.error(t,void 0,n),""}}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){i[e]=this.molV3KtoMolV3KOCL(n[e]);const t=e/n.length*100;r.update(t,`${t?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t,n,i){const r=e.dataFrame,o=this.convertToMolfileV3KColumn(e).toList().map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),s=`molfile(${e.name})`,l=r?r.columns.getUnusedName(s):s;return t?this.getMolV3000ViaOCL(o,l):a.Column.fromStrings(l,o.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=e.dataFrame,n=this.convertToMolfileV3K(e.toList()).map((e=>e.molfile)),i=(0,fi.kA)(t,`molfileV2K(${e.name})`);return a.Column.fromList("string",i,n)}convertToMolfileV3K(e){const t=new Array(e.length);for(let n=0;n<e.length;++n){const i=e[n];if(!i){t[n]=mi.vF.createEmpty();continue}let r;try{r=this.getPolymerMolfile(i)}catch(e){const[t,n]=(0,Ce.AP)(e);Bi.logger.error(t,void 0,n),r=mi.vF.createEmpty()}t[n]=r}return t}getPolymerGraphColumn(e){const t=e.toList(),n=this.helmHelper.getMolfiles(t);return a.Column.fromStrings("mols",n)}getPolymerMolfile(e){const t=this.helmHelper.removeGaps(e),n=t.resHelm,i=new Map;for(const[e,n]of t.monomerMap?.entries()??[])i.set(n,e);const r=this.helmHelper.getMolfiles([n])[0],o=new $i(r),s=new Ni(n,this.rdKitModule,this.monomerLib);o.monomerSymbols.forEach(((e,t)=>{const n=o.getMonomerShifts(t);s.addMonomer(e,t,n)}));const a=s.compileToMolfile(),l=new mi.Cg;for(const[e,t]of a.monomers.entries()){const n=i.get(e);l.set(n,t)}return new mi.vF(a.molfile,l)}}const Ri=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}};class Oi extends a.SemanticValue{get value(){return this.seqHandler.column.get(this.rowIdx)}set value(e){this.seqHandler.column.set(this.rowIdx,e)}get helm(){return this.seqHandler.getHelm(this.rowIdx)}isDna(){return this.seqHandler.alphabet===we.YI.DNA}isRna(){return this.seqHandler.alphabet===we.YI.RNA}isNaturalPeptide(){return this.seqHandler.alphabet===we.YI.PT}isHelm(){return this.seqHandler.isHelm()}constructor(e,t){if(null==t.column.dataFrame)throw new Error("Attribute .dataFrame is required for SeqValueBase from cell");const n=t.column.dataFrame.cell(e,t.column.name);super(a.SemanticValue.fromTableCell(n).dart),this.rowIdx=e,this.seqHandler=t}getSplitted(){return this.seqHandler.getSplitted(this.rowIdx)}getSplittedWithSugarsAndPhosphates(){if(!this.isDna()&&!this.isRna())return this.getSplitted();const e=(0,ke.qp)(this.helm),t=[],n=/\(|\)/;for(let i=0;i<e.length;i++){const r=e.getOriginal(i),o=r.split(n).filter((e=>!!e));3===o.length?(t.push(o[0]),t.push(o[1]),t.push(o[2])):t.push(r)}return new ke.Mu(t,this.seqHandler.defaultGapOriginal)}}class ki{seqHelper;_column;_units;_notation;_defaultGapOriginal;notationProvider;_splitter=null;constructor(e,t){if(this.seqHelper=t,e.type!==a.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${a.TYPE.STRING}'.`);this._column=e;const n=this._column.meta.units;if(!n)throw new Error("Units are not specified in column");this._units=n,this._notation=this.getNotation(),this.isCustom()&&(this.notationProvider=this.column.temp[Ri.notationProvider]??null);const i=this.isFasta()?we.b9[ge.Hi.FASTA]:this.isSeparator()?we.b9[ge.Hi.SEPARATOR]:this.isHelm()?we.b9[ge.Hi.HELM]:this.isCustom()?this.notationProvider.defaultGapOriginal:void 0;if(null==i)throw new Error(`Unexpected defaultGapOriginal for notation '${this.notation}'`);if(this._defaultGapOriginal=i,!this.column.tags.has(ge.gp.aligned)||!this.column.tags.has(ge.gp.alphabet)||!this.column.tags.has(ge.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===ge.YI.UN)if(this.isFasta())this.seqHelper.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(ge.gp.separator);this.seqHelper.setUnitsToSeparatorColumn(this,t)}else if(this.isHelm())this.seqHelper.setUnitsToHelmColumn(this);else{if(!this.isCustom())throw new Error(`Unexpected units '${this.column.meta.units}'.`);this.notationProvider.setUnits(this)}if(!this.column.tags.has(ge.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(ge.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${ge.gp.alphabetIsMultichar}' is mandatory.`);this.columnVersion=this.column.version}static setTags(e){const t=e.column.meta.units;if([ge.Hi.FASTA,ge.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(ge.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(ge.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(ge.gp.aligned,t));let n=e.column.getTag(ge.gp.alphabet);if(null===n&&(n=(0,ke.pc)(e.stats.freq,ge.q7),e.column.setTag(ge.gp.alphabet,n)),n===ge.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(ge.gp.alphabetSize,t.toString()),e.column.setTag(ge.gp.alphabetIsMultichar,n?"true":"false")}}else if(t===ge.Hi.HELM){let t=e.column.getTag(ge.gp.alphabet);null===t&&(t=(0,ke.p0)(e.stats.freq,ge.q7,e.defaultGapOriginal),e.column.setTag(ge.gp.alphabet,t))}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(ge.gp.separator)??void 0;if(this.notation===ge.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(ge.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(ge.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get defaultBiotype(){return this.alphabet===ge.YI.RNA||this.alphabet===ge.YI.DNA?He.o.NUCLEOTIDE:He.o.AA}get helmCompatible(){return this.column.getTag(ge.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==ge.Hi.HELM||this.alphabet==ge.YI.UN){const e=this.column.getTag(ge.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case ge.YI.PT:return 20;case ge.YI.DNA:case ge.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===ge.Hi.HELM||this.alphabet===ge.YI.UN&&"true"===this.column.getTag(ge.gp.alphabetIsMultichar)}cached=!0;_splitted=null;columnVersion=null;getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}getValue(e,t){return this.column.get(e),new Oi(e,this)}getHelm(e){let t;const n=this.column.get(e);return t=this.notation===ge.Hi.HELM?n:this.notation===ge.Hi.CUSTOM?this.notationProvider.getHelm(n,{}):this.getConverter(ge.Hi.HELM)(n),t}_stats=null;get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(t=!1);for(let t=0;t<i.length;++t){const n=i.getCanonical(t);n in e||(e[n]=0),e[n]+=1}}this._stats={freq:e,sameLength:t}}return this._stats}_maxLength=null;get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...re().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}_posList=null;get posList(){if(null===this._posList){const e=this.column.getTag(ge.gp.positionNames);this._posList=e?e.split(ge.z1).map((e=>e.trim())):re().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===ge.Hi.FASTA}isSeparator(){return this.notation===ge.Hi.SEPARATOR||!!this.separator}isHelm(){return this.notation===ge.Hi.HELM}isCustom(){return this.notation===ge.Hi.CUSTOM}isRna(){return this.alphabet===ge.YI.RNA}isDna(){return this.alphabet===ge.YI.DNA}isPeptide(){return this.alphabet===ge.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return ge.Hi.FASTA;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return ge.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.Hi.HELM;if(this.units.toLowerCase().startsWith(ge.Hi.CUSTOM))return ge.Hi.CUSTOM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const r=this.column,o=e.toLowerCase()+"("+r.name+")",s=n??r.dataFrame?.columns.getUnusedName(o)??o,l=a.Column.fromList("string",s,i??new Array(this.column.length).fill(""));if(l.semType=a.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===ge.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${ge.Hi.SEPARATOR}' requires separator value.`);l.setTag(ge.gp.separator,t)}l.setTag(a.TAGS.CELL_RENDERER,e===ge.Hi.HELM?"helm":"sequence");const c=r.getTag(ge.gp.aligned);c&&l.setTag(ge.gp.aligned,c);let h=r.getTag(ge.gp.alphabet);h||this.notation!==ge.Hi.HELM||e===ge.Hi.HELM||(h=ge.YI.UN),null!=h&&l.setTag(ge.gp.alphabet,h);let u=r.getTag(ge.gp.alphabetSize);null!=h&&u&&l.setTag(ge.gp.alphabetSize,u);const d=r.getTag(ge.gp.alphabetIsMultichar);return null!=h&&void 0!==d&&l.setTag(ge.gp.alphabetIsMultichar,d),e==ge.Hi.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(ge.gp.alphabetSize,u)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static unitsStringIsValid(e){return e=e.toLowerCase(),[ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!ki.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=a.Column.fromList("string",t,new Array(e).fill(""));return i.semType=a.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(ge.Hi.FASTA))return null===this.column.getTag(ge.gp.alphabet)||this.getAlphabetIsMultichar()?ge.J9:ke.tm;if(this.units.toLowerCase().startsWith(ge.Hi.SEPARATOR))return(0,ge.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(ge.Hi.HELM))return ge.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return ct.Z.HAMMING;switch(this.alphabet){case ge.YI.DNA:case ge.YI.RNA:case ge.YI.PT:}return ct.Z.LEVENSHTEIN}getDistanceFunction(){return ct.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(ge.gp.isHelmCompatible))return"true"===this.column.getTag(ge.gp.isHelmCompatible);const e=(await(0,be.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,ge.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let e=0;e<i;++e){const i=r[e];if(!(i in n)){n.add(i);const r=this.getSplitted(e);for(let e=0;e<r.length;++e){const n=r.getCanonical(e);if(!t.has(n))return this.column.setTag(ge.gp.isHelmCompatible,"false"),!1}}}return this.column.setTag(ge.gp.isHelmCompatible,"true"),!0}toFasta(e){return e===ge.Hi.FASTA}toSeparator(e){return e===ge.Hi.SEPARATOR}toHelm(e){return e===ge.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?we.b9[ge.Hi.FASTA]:we.b9[ge.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),o=(0,ge.qp)(e),s=[];for(let e=0;e<o.length;++e){let n=o.getOriginal(e);if(r&&(n=n.replace(gn.EK,"$1")),n===we.b9[ge.Hi.HELM])s.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";s.push(e)}else s.push(n)}return s.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=e??0,o=t??this.maxLength-1,s=this.getJoiner(),a=o-r+1,l=we.b9[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(a);for(let e=0;e<a;++e){const i=r+e;n[e]=i<t.length?t.getOriginal(i):l}return s(new ke.Mu(n,l))}));const c=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(a);for(let e=0;e<a;++e){const i=r+e;n[e]=i<t.length?t[i]:"?"}return n.join(ge.z1)},h=this.column.getTag(ge.gp.positionNames);h&&i.setTag(ge.gp.positionNames,c(h));const u=this.column.getTag(ge.gp.positionLabels);return u&&i.setTag(ge.gp.positionLabels,c(u)),i}_joiner=void 0;get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const r=this;switch(t){case ge.Hi.FASTA:i=function(e){return r.joinToFasta(e,r.isHelm())};break;case ge.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return Gi(e,n,r.isHelm())};break;case ge.Hi.HELM:{const e=r.alphabet===ge.YI.DNA||r.alphabet===ge.YI.RNA,t=r.getHelmWrappers();i=function(n){return Fi(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===ge.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${ge.Hi.SEPARATOR}'.`);const n=this;if(e===ge.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===ge.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===ge.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e,t){let n=e.temp[Ri.seqHandler];return n&&n.columnVersion===e.version||(n=e.temp[Ri.seqHandler]=new ki(e,t)),n}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const r=e.getOriginal(i);let o=e.getOriginal(i);t&&(o=o.replace(gn.EK,"$1")),r===we._S?o=we.b9[ge.Hi.FASTA]:r===gn.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return Gi(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==ge.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return Fi(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let o=t.getOriginal(e);(i||r)&&(o=o.replace(gn.EK,"$1"),o=o===gn.q7?null:o),n[e]=o||null}return new ke.Mu(n.filter((e=>!!e)),we.b9[ge.Hi.HELM])}getRendererBack(e,t){const n=this.column.temp;let i=n.rendererBack;return i||(i=n.rendererBack=this.notationProvider.createCellRendererBack(e,t)),i}}function Gi(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let o=e.getOriginal(t);n&&(o=o.replace(gn.EK,"$1")),r===we._S?o=we.b9[ge.Hi.SEPARATOR]:r===gn.q7&&(o=""),i[t]=o}return i.join(t)}function Fi(e,t,n){const[i,r,o,s]=t,a=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=e.getOriginal(t);i===we._S?s=we.b9[ge.Hi.HELM]:(n&&(s=s.replace(gn.EK,"$1")),s=1===s.length?`${r}${s}${o}`:`${r}[${s}]${o}`),a[t]=s}return`${i}${a.join(".")}${s}`}class Hi{libHelper;rdKitModule;constructor(e,t){this.libHelper=e,this.rdKitModule=t}getSeqHandler(e){return ki.forColumn(e,this)}getSeqMonomers(e){const t=this.getSeqHandler(e);return Object.keys(t.stats.freq)}async getHelmToMolfileConverter(e){const t=await(0,Rt.b2)();return new Pi(t,this.rdKitModule,e)}helmToAtomicLevelSingle(e,t,n,i=!0){if(!e)return mi.vF.createEmpty();const r=t.convertToMolfileV3K([e])[0];if(!r||!r.molfile)return mi.vF.createEmpty();let o=null;try{let e=r.molfile;if(i){if(o=this.rdKitModule.get_mol(e),!o)return mi.vF.createEmpty();o.set_new_coords(),o.normalize_depiction(1),o.straighten_depiction(!0),e=o.get_v3Kmolblock()}return n&&(e=t.molV3KtoMolV3KOCL(e)),new mi.vF(e,r.monomers)}catch(e){const[t,n]=(0,Ce.AP)(e);return Bi.logger.error(t,void 0,n),mi.vF.createEmpty()}finally{o?.delete()}}async helmToAtomicLevel(e,t,n,i){const r=i??this.libHelper.getMonomerLib(),o=e.dataFrame,s=(0,fi.qj)(o,e.name),l=await this.getHelmToMolfileConverter(r),c=e.toList(),h=new Array(e.length),u=a.Func.find({package:"Chem",name:"beautifyMols"})[0];for(let n=0;n<e.length;n++)h[n]=this.helmToAtomicLevelSingle(c[n],l,t,!u).molfile;if(u){const t=await u.apply({mols:h});if(t&&Array.isArray(t)&&t.length===e.length)for(let n=0;n<e.length;n++)t[n]&&(h[n]=t[n])}const d=a.Column.fromStrings(s,h);return d.semType=a.SEMTYPE.MOLECULE,d.meta.units=a.UNITS.Molecule.MOLBLOCK,d.setTag(".sequence-src-col",e.name),{molCol:d,warnings:[]}}setUnitsToFastaColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.FASTA)throw new Error(`The column of notation '${ge.Hi.FASTA}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=ge.Hi.FASTA,ki.setTags(e)}setUnitsToSeparatorColumn(e,t){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE||e.column.meta.units!==ge.Hi.SEPARATOR)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must be '${a.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${ge.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=ge.Hi.SEPARATOR,e.column.setTag(ge.gp.separator,t),ki.setTags(e)}setUnitsToHelmColumn(e){if(e.column.semType!==a.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${ge.Hi.HELM}' must be '${a.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=ge.Hi.HELM,ki.setTags(e)}}const Bi=new oi;async function Di(){return await un.getInstance()}class Vi{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}let ji=null;async function Ui(){null===ji&&(ji=async function(){const e="Bio: _package.initBio()";Bi.logger.debug(`${e}, start`);const t=window.performance.now(),n=await(0,$e.j)(),i=await Bi.getProperties(),r=new ri(i);Bi.properties=r;const o=await un.getInstance(),s=await(0,Ne.ub)();s.explicit&&(s.explicit=[],await(0,Ne.Eu)(s)),await o.awaitLoaded(1/0),o.initialLoadCompleted||await o.loadMonomerLib(),o.loadMonomerSets();const a=o.getMonomerLib(),l=o.getMonomerSets(),c=window.performance.now();Bi.logger.debug(`${e}, loading ET: ${c-t} ms`);const h=new Hi(o,n);Bi.completeInit(h,a,l,n),Bi.logger.debug(`${e}, end`)}()),await ji}function Wi(e){const t=new ai(e,Bi.seqHelper);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)})),t}function qi(){return Bi.monomerLib}function zi(e){return Bi.seqHelper.getSeqHandler(e)}function Yi(e){const t="getRegionTopMenu",n=a.Func.find({package:Bi.name,name:t});if(1!==n.length)throw new Error(`Package '${Bi.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new ui(i,Bi.seqHelper).widget()}async function Ki(e){return async function(){const e=s.label("Manage monomer libraries");return pn()(e).addClass("d4-link-action"),e.onclick=async()=>await Bn(),new a.Widget(e)}()}function Zi(e){try{new ui(e,Bi.seqHelper).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),Bi.logger.error(t,void 0,n)}}function Xi(e){const t=new Qn;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function Ji(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function Qi(e){const t=new Se({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function er(){return new qe}function tr(){return new qe}function nr(){return new qe}function ir(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=Bi.properties?Bi.properties.maxMonomerLength:4;if(Re.gp.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Re.gp.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"});let r=Bi.properties?Bi.properties.fontSize:12;".mm.cellRenderer.fontSize"in e.temp&&e.temp[".mm.cellRenderer.fontSize"]&&!isNaN(e.temp[".mm.cellRenderer.fontSize"])&&(r=e.temp[".mm.cellRenderer.fontSize"]);const o=s.input.int("Font Size",{value:r,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(t&&t>0){const n=t??12;e.temp[".mm.cellRenderer.fontSize"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The font size of monomer symbol in sequence renderer"}),l=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Be.s.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),c=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),h=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),u=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),d=s.inputs([o,i,l,h,c,u]);return new a.Widget(d)}(e)}function rr(e){return(0,si.j)(e,Bi.monomerLib,Bi.seqHelper)}function or(){return new Ye}function sr(e,t,n,i,r){const o=new lt.$(i,r,n,t);return"Local alignment"==e?o.smithWaterman():o.needlemanWunsch()}function ar(){return new nt.oP}function lr(){return new at}function cr(e,t,n,i){return li(e,t??null,n??null,i??null)}async function hr(e,t,n,i,r){const s=li(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}async function ur(e,t,n,i,r,h,u,d,p){if(!(0,Kn.V)(t,"Activity Cliffs"))return;const m=Ie(e),f={units:t.meta.units,aligned:t.getTag(ge.gp.aligned),separator:t.getTag(ge.gp.separator),alphabet:t.getTag(ge.gp.alphabet)},g=h,y=t,b=async()=>await me(e,y,m,"Activity cliffs",n,i,g,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,u,dt,pt,yt,void 0,p),v=r===c.c.UMAP?2e5:2e4,w=r===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{b().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():b().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,Ce.AP)(e);throw Bi.logger.error(t,void 0,n),e})).finally((()=>{C.close()}))}async function dr(e,t,n=1,i=.6,r="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:o,options:s}=await ht(e,t,r);return{entries:o,options:{...s,gapOpen:n,gapExtend:i}}}async function pr(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ut.BQ)(e,Bi.seqHelper,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=V.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}async function mr(e,t,i,r,c,h,u,d,p){const m=o.shell.tv.dataFrame==e?o.shell.tv:void 0;if((0,Kn.V)(t,"Sequence Space"))return h||(h=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),u??={},await async function(e,t,i,r,c,h,u,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={},b){const v={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==h.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const w=d?f.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,C=async()=>{const C=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const S=Ie(e);function x(n,r,o){let c=null,h=null;e.columns.names().includes(S[0])?(c=e.columns.byName(S[0]),h=e.columns.byName(S[1])):(c=e.columns.add(a.Column.float(S[0],e.rowCount)),h=e.columns.add(a.Column.float(S[1],e.rowCount)),d&&!A&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Te(t,i)}))),f[l.YP]&&(A?.root&&s.setUpdateIndicator(A.root,!1),c.init((e=>o[0]?o[0][e]:void 0)),h.init((e=>o[1]?o[1][e]:void 0)));const u=n/r*100;C.update(u,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${u.toFixed(0)}%`)}async function E(){e.columns.add(a.Column.float(S[0],e.rowCount)),e.columns.add(a.Column.float(S[1],e.rowCount));let n=null;d&&(A=w.scatterPlot({...v,x:S[0],y:S[1],title:f.scatterPlotName??Te(t,i)}),s.setUpdateIndicator(A.root,!0));const p=o.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(o.events.fireCustomEvent(q.S,{}),p.unsubscribe(),n?.(),C.close())})),g=new Promise((async(o,s)=>{try{n=o;const s=[];let a=r,d=c,p=u;if(b&&t.every((e=>e.isNumerical))){const n=t.map((e=>e.toList())),i=new Array(e.rowCount).fill(0).map(((e,n)=>new Float32Array(t.length)));for(let r=0;r<t.length;++r)for(let t=0;t<e.rowCount;++t)i[t][r]=n[r][t];m.distanceFnArgs=[{}],s.push({entries:i,options:{}}),a=[b],d=[1],p="MANHATTAN"}else for(let e=0;e<h.length;++e){const n=h[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[o]:r[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};s.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}o(await Y(s.map((e=>e.entries)),i,a,d,u,m,f[l.vb]?void 0:x))}catch(e){s(e)}})),y=await g;return C.close(),p.unsubscribe(),y}const _=await E();if(p&&_){const M=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,i,r){return Me(this,void 0,void 0,(function*(){return new Promise((function(o,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):o(t)}}))}))}(_[0],_[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),T=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(T).init((e=>I[e].toString())),A&&(A.props.colorColumnName=T)}catch(L){o.shell.error("Clustering embeddings failed"),console.error(L)}finally{M.close()}}if(_){const N=e.columns.byName(S[0]),$=e.columns.byName(S[1]);if(N.init((e=>_[0][e])),$.init((e=>_[1][e])),g)try{const P=g.inputs[0].name,R=g.inputs[1].name;await g.prepare({[P]:N,[R]:$,...y}).call(!0)}catch(O){o.shell.error("Post-processing 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t=s.divText(""),n=a.Widget.fromRoot(t);try{if(!e||!e.value)return t.innerText="No sequence provided",n;if(!(e.cell&&e.cell.dart&&e.cell.dataFrame&&e.cell.column))return t.innerText="Atomic level conversion requeires a sequence column",n;if(![ge.Hi.FASTA,ge.Hi.SEPARATOR,ge.Hi.HELM].includes(e.cell.column.meta.units?.toLowerCase()??""))return t.innerText="Unsupported sequence notation. please use Bio | Polytool | Convert",n;const i=(await ao()).getSeqHandler(e.cell.column);if(!i)return t.innerText="No sequence handler found",n;if((i.getSplitted(e.cell.rowIndex,50)?.length??100)>40)return t.innerText="Maximum number of monomers is 40",n;const r=a.Column.fromStrings("singleVal",[e.value]),l=a.DataFrame.fromColumns([r]);if(Object.entries(e.cell.column.tags).forEach((([e,t])=>{r.setTag(e,t)})),await fr(l,r,e.cell.column.meta.units===ge.Hi.HELM,!1),l.columns.length<2)return t.innerText="No structure generated",n;const c=l.columns.byIndex(1),h=c.get(0);if(!h)return t.innerText="No structure generated",n;c.semType=a.SEMTYPE.MOLECULE;const u=a.SemanticValue.fromTableCell(l.cell(0,c.name)),d=s.panels.infoPanel(u);let p=null;d&&(p=a.Widget.fromRoot(d.root));const m=o.chem.drawMolecule(h,300,300,!1);return m.style.cursor="pointer",s.tooltip.bind(m,"Click to expand"),m.onclick=()=>{const e=window.innerWidth-200,t=window.innerHeight-200,n=o.chem.drawMolecule(h,e,t,!1);s.dialog({title:"Molecule"}).add(n).showModal(!0)},p&&p.root.prepend(m),p??a.Widget.fromRoot(m)}catch(e){Bi.logger.error(e)}return t.innerText="No Structure generated",n}(e)}function br(){(0,Xn.D)({},Bi.seqHelper).catch((e=>{const[t,n]=(0,Ce.AP)(e);if(e instanceof Zn.Ap)return o.shell.warning(e.element),void Bi.logger.warning(t);o.shell.error(t),Bi.logger.error(t,void 0,n)}))}async function vr(e=null,t=null,n){return(0,Xn.D)({col:e,clustersCol:t,...n},Bi.seqHelper)}async function wr(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(Bi.seqHelper.getSeqHandler(e),!0))),n=async t=>{if(!(0,Kn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>Bi.seqHelper.getSeqHandler(e).isMsa())),r=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Cr(e){return new ye.m(e).importFasta()}function Ar(e){return console.log(e),[]}function Sr(){const e=(0,Pe.me)()[0];(0,Et.C)(e,Bi.seqHelper)}function xr(e){(0,Et.C)(e,Bi.seqHelper)}function Er(){return new ni}async function _r(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const t=await o.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${e}`,s}async function Mr(e,t){return await async function(e,t){if(await(0,Je.cb)(10),!(0,Kn.V)(t,"Sequence space"))return e;const n=Bi.seqHelper,i=(0,ve.R)(t,n);i.name="splitToMonomers";const r=t.dataFrame;for(const e of i.columns)e.semType=je.uF.MONOMER,e.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const s=/(\d+)(?: \((\d+)\))?/,l=e=>{s.lastIndex=0;const t=e.match(s);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<i.columns.length;e++){const n=i.columns.byIndex(e);n.semType=je.uF.MONOMER,n.setTag(we.gp.alphabet,t.getTag(we.gp.alphabet));const o=100;let s=0;for(;r.columns.byName(n.name)&&s<o;)n.name=l(n.name),s++;r.columns.add(n)}await o.data.detectSemanticTypes(r);for(let e=0;e<i.columns.length;e++){const t=i.columns.byIndex(e);t.setTag(a.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return r}(e,t)}function Ir(e){return Bi.seqHelper.getSeqMonomers(e)}function Tr(){return new Ct(Bi.seqHelper)}function Lr(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function Nr(){return new St(Bi.seqHelper)}function $r(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function Pr(e){const t=(0,Pe.me)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ut.a7(t,Bi.seqHelper)}function Rr(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}async function Or(e,t,n){const i=Bi.seqHelper;return pi(e,t,n,fe.IDENTITY,i)}async function kr(e,t,n){const i=Bi.seqHelper;return pi(e,t,n,fe.SIMILARITY,i)}async function Gr(){Bn()}async function Fr(){await Dn()}async function Hr(){const e=await En.getInstance();await e.getViewRoot()}async function Br(){return await Dn(!1)}async function Dr(e,t){(await(await un.getInstance()).getFileManager()).getValidLibraryPaths().forEach((t=>{const n=t.endsWith(".json")?t.substring(0,t.length-5):t;e.item(n).onSelected.subscribe((async()=>{const e=await En.getInstance();await e.getViewRoot(t,!0),e.resetCurrentRowFollowing()}))}))}function Vr(){(0,_t.TE)()}function jr(){return new Mt._i(Bi.seqHelper,Bi.logger)}function Ur(){return new Mt._i(Bi.seqHelper,Bi.logger)}async function Wr(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Jn(e,"webLogoLargeApp"),n=await Bi.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function qr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Jn(e,"webLogoAggApp"),n=await Bi.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function zr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new hi(e,"getRegionApp");await t.init()}finally{e.close()}}async function Yr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await Bi.files.readCsv("samples/HELM_empty_vals.csv"),n=new hi(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function Kr(){const e=a.DataFrame.fromColumns((0,Le.dW)());o.shell.addTableView(e)}function Zr(){const e=a.DataFrame.fromColumns([(0,Le.Hx)(Bi.seqHelper,ge.Hi.FASTA)]);o.shell.addTableView(e)}function Xr(){const e=a.DataFrame.fromColumns([(0,Le.Hx)(Bi.seqHelper,ge.Hi.HELM)]);o.shell.addTableView(e)}function Jr(e,t){!function(e,t,n){const i=n.getSeqHandler(e.column),r=Object.values(ge.Hi).filter((e=>e!==i.units));t.group("Copy").items(r,(t=>{const i=e.column,r=e.rowIndex,s=n.getSeqHandler(i),a=t===ge.Hi.SEPARATOR?Bi.properties.defaultSeparator:void 0,l=s.getJoiner({notation:t,separator:a})(s.getSplitted(r));navigator.clipboard?(navigator.clipboard.writeText(l),o.shell.info(`Value of notation '${t}' copied to 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o.functions.eval("Bio:SeqSpaceDemo"),t=await o.dapi.projects.find(e.id);await t.open(),o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#sequence-space")}()}async function to(){await async function(){const e=await Bi.files.readCsv("tests/helm_cyclic_cliffs.csv");e.name="Activity Cliffs Demo",await o.data.detectSemanticTypes(e),await e.meta.detectSemanticTypes();const t=o.shell.addTableView(e);s.setUpdateIndicator(t.root,!0);try{const n=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=await ur(e,e.getCol("Sequence"),e.getCol("Activity"),96,c.c.UMAP,ct.Z.MONOMER_CHEMICAL_DISTANCE,n,{},!0);t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.65),await a.delay(100),pn()(i.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click(),await a.delay(100),t.grid.props.rowHeight=180,t.grid.col("sequence")&&(t.grid.col("sequence").width=300),t.grid.col("structure")&&(t.grid.col("structure").width=300);const r=Array.from(t.viewers).find((e=>e!==t.grid&&e.type===a.VIEWER.GRID));r&&(r.props.rowHeight=40,r.col("seq_diff").width=600,t.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Cliffs",.35),t.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.55))}catch(e){!function(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),Bi.logger.error(e.message,void 0,n)}(e)}finally{s.setUpdateIndicator(t.root,!1)}o.shell.windows.help.showHelp("/help/datagrok/solutions/domains/bio/bio.md#activity-cliffs")}()}async function no(){await async function(){const e=await Bi.files.readCsv("samples/HELM_BI_CYCLIC.csv");e.name="To Atomic Level",await e.meta.detectSemanticTypes(),await o.data.detectSemanticTypes(e);const t=o.shell.addTableView(e),n=e.col("HELM");await fr(e,n,!0,!1),(0,Pe.Kd)(t.grid,"molfile(HELM)",500,300,!0),(0,Pe.Kd)(t.grid,"HELM",500,void 0,!0),o.shell.info("Hover over monomers in HELM column to highlight them in molecular 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Bi.logger.error(t,void 0,n),e}}async function so(e,t,n){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const h=a.DataFrame.fromCsv(e),u=t?h.getCol(t):h.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:u})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Je.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}async function ao(){return await Ui(),Bi.seqHelper}function lo(e,t,n){return async function(e,t,n=!0,i){const r=Bi.seqHelper,o=(await r.getHelmToMolfileConverter(i)).convertToRdKitBeautifiedMolfileColumn(t,n,Bi.rdKitModule,i);return 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e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const s=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>e&&(e=this.dpGrid[i][r].value,t=i,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}},8115:(e,t,n)=>{"use strict";n.d(t,{BQ:()=>m,a7:()=>u,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(8070),a=n(2003),l=n(1407),c=n(4870);const h="substr_helm";class u{seqHelper;units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e,t){this.seqHelper=t,this.col=e[0],this.createUI()}editHelmLinkAction(){(0,c.Ku)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(h,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===a.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===a.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,c.Ku)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=o.DataFrame.create(1);t.columns.addNewString(h).init((e=>"")),t.col(h).semType=this.col.semType,t.col(h).meta.units=a.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(a.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===a.Hi.HELM?t.get(h,0):this.substructureInput.value;this.units===a.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===a.Hi.HELM?await p(n,this.col,this.seqHelper):d(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,r=e.charAt(e.length-1)===t,o=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(e,n):e,r=o.BitSet.create(t.length);for(let n=0;n<t.length;n++){const o=t.get(n);(o.match(i)||o===e)&&r.set(n,!0,!1)}return r}async function p(e,t,n){t.version!==t.temp["last-invalidated-version"]&&await m(t,n,!0);const r=o.Column.string("helm",1).init((t=>e));r.semType=o.SEMTYPE.MACROMOLECULE,r.meta.units=a.Hi.HELM;const s=await(0,l.R)(r,n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:s.get(0),molBlockFailover:""})).get(0)}async function m(e,t,n){const i=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,s.cb)(10);const i=new Map,r=await(0,l.R)(e,t,n,i);e.temp["monomeric-mols"]=r,e.temp["monomers-dict"]=i,e.temp["last-invalidated-version"]=e.version}finally{i.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>s,l:()=>a});var i=n(4328),r=n(6082),o=n(5605);function s(e,t,n=[],r=[],s=!0){const l=o._package.seqHelper,[c,h]=a(e,t,l,n,r);return s&&!c&&i.shell.warning(h),c}function a(e,t,n,o=[],s=[]){let a=!0,l="";if(e.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const i=n.getSeqHandler(e),r=i.notation;if(o.length>0&&!o.some((e=>r.toUpperCase()==e.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==o.length?"any notation":`notation${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!i.isHelm()){const e=i.alphabet;s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>h,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",h={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{C:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003);let c=null,h=[];function u(e,t){let n=e??o.shell.t.columns.bySemType("Macromolecule");if(!n)throw new Error("No column with Macromolecule semantic type found");let s=t.getSeqHandler(n),u=s.notation;const d=r.divText("Current notation: "+u,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:n,filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE,nullable:!1,onValueChanged:e=>(n=e,s=t.getSeqHandler(n),u=s.notation,u===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+u,g=p.filter((e=>e!==u)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),c?.clear(),void c?.add(r.div([d,m.root,v.root,y.root])))}),f=["-",".","/"];let g=p.filter((e=>e!==u));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==c&&(c=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const e=v.value,i=e===l.Hi.SEPARATOR?y.value:void 0;await async function(e,t,n,i){const r=t.getSeqHandler(e).convert(n,i);e.dataFrame.columns.add(r);const s=await o.functions.call("Bio:detectMacromolecule",{col:r});return s&&(r.semType=s),await o.data.detectSemanticTypes(e.dataFrame),r}(n,t,e,i)})).show({x:350,y:100}),h.push(c.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],c=null}))))}},536:(e,t,n)=>{"use strict";n.d(t,{Z:()=>r});var i=n(6956);class r{constructor(e){const t=e.split(i.xe).filter((e=>e));t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const r=i[t],o=e.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),e.push(n)})),e}}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},9099:(e,t,n)=>{"use strict";n.d(t,{f:()=>s});var i=n(536),r=n(6956),o=n(9034);class s{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(r.pk),n=t[0].split(r.xe);this.simplePolymers=n.map((e=>new o.d(e))),this.connectionList=new i.Z(t[1]),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=this.simplePolymers.map((e=>e.monomers.length)).reduce(((e,t)=>e+t),0),t=Array.from({length:e},(()=>[]));return this.bondData.forEach((e=>{e.forEach((e=>{const n=e.monomerIdx,i=e.rGroupId;t[n].push(i)}))})),t}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,i),t.push(...i)})),this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,i.push(r)})),t.push(i)})),t}}},9034:(e,t,n)=>{"use strict";n.d(t,{d:()=>r});var i=n(8438);class r{simplePolymer;isNucleotideSequence=!1;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.isNucleotideSequence="RNA"===this.polymerType,this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],r=[];return t.forEach((e=>{if(this.isNucleotideSequence){const t=e.split(/\(|\)/).filter((e=>!!e)).map((e=>(0,i.D)(e)));n.push(...t),t.forEach(((e,t)=>r.push(t%3==1?"Branch":"Backbone")))}else n.push((0,i.D)(e)),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],r=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],r=i-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}},8604:(e,t,n)=>{"use strict";n.d(t,{Es:()=>r,G3:()=>s,gt:()=>o,so:()=>i});const i="System:AppData/Bio/monomer-libraries/",r="System:AppData/Bio/monomer-sets/",o="System:AppData/Bio/tests/libraries/HELMmonomerSchema.json",s={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>M});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(608),c=n(8152),h=n(966),u=n(4139),d=n(5072),p=n.n(d),m=n(7825),f=n.n(m),g=n(7659),y=n.n(g),b=n(5056),v=n.n(b),w=n(540),C=n.n(w),A=n(1113),S=n.n(A),x=n(6369),E={};E.styleTagTransform=S(),E.setAttributes=v(),E.insert=y().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=C(),p()(x.A,E),x.A&&x.A.locals&&x.A.locals;var _=n(5605);async function M(e,t){return new Promise((async(n,a)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=u.HX.pepsea.method,e.pepsea.gapOpen??=u.HX.pepsea.gapOpen,e.pepsea.gapExtend??=u.HX.pepsea.gapExtend;const h=e.col?.dataFrame??i.shell.t,d=e.col??h.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==d){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(e),void a(new l.Ap(o.divText(e)))}const p=o.input.choice("Method",{value:e.pepsea.method,items:c.ZY});p.setTooltip("Alignment method");const m=o.input.float("Terminal gap",{value:e?.kalign?.terminalGap});m.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const f=o.p(`Kalign version: ${u.b9}`,"kalign-version"),g=o.input.float("Gap open",{value:e.pepsea.gapOpen});g.setTooltip("Gap opening penalty at group-to-group alignment");const y=o.input.float("Gap extend",{value:e.pepsea.gapExtend});y.setTooltip("Gap extension penalty to skip the alignment");const b=o.inputs([g,y,m]),v=o.button("Alignment parameters",(()=>{b.hidden=!b.hidden,[g,y,m].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending 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i=n(4328),r=n(6077),o=n(2003),s=n(8312),a=n(5553),l=n(966),c=n(330);async function h(e,t,n,h,u,d,p){let m;if(n){const n=await(0,s.Q)(),i=n.getSeqHandler(t);let r,a;i.isHelm()?r=t:(a=t.name,t.name=`__${a}`,r=i.convert(o.Hi.HELM),r.name=a,e.columns.add(r,!1));try{m=await n.helmToAtomicLevel(r,!0,!0,u)}finally{r!==t&&(e.columns.remove(r.name),t.name=a)}}else{if(!(0,l.l)(t,"To Atomic Level",d)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,r.C4)(e,t,u,d,p)}if(m.molCol){const r=(0,c.qj)(e,t.name);m.molCol.name=r,e.columns.add(m.molCol,!0),await(0,a.Qc)(t,m.molCol,u,d,p,n),m.molCol.setTag(".sequence-src-highlight-monomers",String(h)),await i.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";n.d(t,{Kd:()=>a,Ku:()=>s,me:()=>o});var i=n(4328),r=n(6082);function o(){const e=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);return null===e?(i.shell.error("Current table does not contain macromolecules"),[]):e}function 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A{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?o.Column.fromFloat32Array(n,e):e instanceof 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p=Object.entries(this._freqs).sort(((e,t)=>e[0]!==g._S&&t[0]!==g._S?t[1].value-e[1].value:e[0]===g._S&&t[0]===g._S?0:e[0]===g._S?-1:1));for(const[n,i]of p){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((e-t)*l*s,u,a*l,n),u+=n}}render(e,t,n,i,r,o){for(const[s,a]of Object.entries(this._freqs))if(s!==g._S){const l=(0,u.zS)(s,5),c=a.bounds,h=c.left;let d=y.S$;o&&(d=o.getMonomerTextColor(r,s)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(h,c.top,c.width,c.height),e.fillStyle=d,e.textAlign="left",e.font=t;const p=e.measureText(l);e.setTransform(c.width/p.width,0,0,c.height/i,h,c.top),e.fillText(l,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol 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E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const _=new class{render=20};class M extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHelper;seqHandler;initialized=!1;monomerLib=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===d.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===d.mH.ON?this.positionMargin:0}constructor(){super(),this.seqHelper=C._package.seqHelper,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA,semType:o.SEMTYPE.MACROMOLECULE});const e=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],t=Object.values(o.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA,columnTypeFilter:"numerical"}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(d.fH)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(d.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(d.P4)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(d.mH)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(d.lT)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",(0,C.getMonomerLibHelper)().then((e=>{this.monomerLib=e.getMonomerLib(),this.render(E.Render,"monomerLib"),this.subs.push(this.monomerLib.onChanged.subscribe((()=>{this.render(E.Render,"monomerLib changed")})))})),this.viewSyncer=new f.g(C._package.logger)}static viewerCounter=-1;viewerId=++M.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexGrow:"0",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,u.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1)}}getFilter(){let e;switch(this.filterSource){case d.lT.Filtered:e=this.dataFrame.filter;break;case d.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=d.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const r=t>i;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===d.Lp.TOP?"start":this.verticalAlignment===d.Lp.MIDDLE?"center":this.verticalAlignment===d.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}_onSizeChanged=new h.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new h.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new h.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,e.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(g._S)||e.getFreq(g._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new h.Subject;renderRequestSub;render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(u.gp.positionNames),t=this.seqCol.getTag(u.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(u.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(u.z1).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(u.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=this.seqHelper.getSeqHandler(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}this.dataFrame.rowCount;const l=i.getSelectedIndexes();for(let e=0;e<s;++e){for(const t of l){const n=this.seqHandler.getSplitted(t),i=e+this.startPosition<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?g._S:i,o=this.positions[e],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(const n of l){const i=this.seqHandler.getSplitted(n),r=e+this.startPosition<i.length?i.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,o=this.seqHandler.defaultGapOriginal===r?g._S:r,s=t.get(n);this.positions[e].getFreq(o).push(s)}this.positions[e].aggregate(this.valueAggrType)}}const h=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.seqHandler.getAlphabetSize();this.positionHeight==d.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=o.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,r,o,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=o[t],i=e.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const h=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],u=(l-s)*n*t+i*t/2,d=(r*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2,h=this.seqHandler.defaultBiotype;for(let e=r;e<=s;e++)this.positions[e].render(a,i,l,c,h,this.monomerLib)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===d.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===d.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){if(!this.monomerLib||!this.seqHandler)return;const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[r.divText(`Position ${s.label}`)];if(this.valueAggrType===o.AGG.TOTAL_COUNT){const t=this.seqHandler.defaultBiotype;e.push(s.buildCompositionTable(t,this.monomerLib))}const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=r.divV(t);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,r,o){const s=t.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new h.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,m.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>x});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),h=n(8070),u=n(7602),d=n(8115),p=n(4574),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),v=n(5605);class w extends p.O{seqHelper;emptyProps=new p.n("",void 0,v._package.logger);helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++w.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e,void 0,v._package.logger)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}})).onCancel((()=>{f()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Ku)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,b.Ku)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,h.cb)(10),await(0,d.if)(this.props.substructure,e,this.seqHelper)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class A{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class S extends p.n{separator;constructor(e,t,n){super(e,!1,n),this.separator=t,this.readOnly=!0}}class x extends r.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new u.g(this.logger)}static filterCounter=-1;filterId=++x.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new E:this.notation===c.Hi.SEPARATOR?new _(this.column.getTag(c.gp.separator)):new w(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,h.cb)(10),await(0,h.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class E extends p.O{emptyProps=new p.n("",void 0,v._package.logger);substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e,void 0,v._package.logger),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,d.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class _ extends p.O{emptyProps=new S("",void 0,v._package.logger);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new S(e,this.props.separator,v._package.logger),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new S(this.props.substructure,t,v._package.logger),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("",void 0,v._package.logger)}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,d.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>E,j:()=>x});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(439),c=n(3599),h=n(5072),u=n.n(h),d=n(7825),p=n.n(d),m=n(7659),f=n.n(m),g=n(5056),y=n.n(g),b=n(540),v=n.n(b),w=n(1113),C=n.n(w),A=n(5999),S={};function x(e,t,n){const o=i.div();o.classList.add("macromolecule-cell-comp-analysis-host");const l=e.cell.column.tags[a.gp.alphabet],h=l===a.YI.DNA||l===a.YI.RNA?c.o.NUCLEOTIDE:c.o.AA,u={},d=n.getSeqHandler(e.cell.column),p=e.cell.rowIndex,m=d.getSplitted(p);s().count(0).take(m.length).filter((e=>!m.isGap(e))).forEach((e=>{let t=m.getCanonical(e);h===c.o.NUCLEOTIDE&&d.isHelm()&&"("===t[1]&&")"===t[t.length-2]&&(t=t.substring(2,t.length-2));const n=u[t]||0;u[t]=n+1}));const f=E(u,h,t);return Array.from(f.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),o.appendChild(f),new r.Widget(o)}function E(e,t,n){let o=0,s=null;for(const t of Object.values(e))o+=t,s=null===s?t:Math.max(s,t);const a=s/o,c=Object.assign({},...Array.from(Object.entries(e)).sort(((e,t)=>t[1]-e[1])).map((([e,s])=>{const c=s/o,h=n.getWebEditorMonomer(t,e).backgroundcolor,u=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});u.style.width=50*c/a+"px",u.style.backgroundColor=h,l._S===e&&(u.style.borderWidth="1px",u.style.borderStyle="solid",u.style.borderColor=r.Color.toHtml(r.Color.lightGray));const d=l._S===e?"-":e,p=i.div(`${(100*c).toFixed(2)}%`),m=i.div([u,p],{classes:"macromolecule-cell-comp-analysis-value"});return{[d]:m}}))),h=i.tableFromMap(c);return Array.from(h.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),h}S.styleTagTransform=C(),S.setAttributes=y(),S.insert=f().bind(null,"head"),S.domAPI=p(),S.insertStyleElement=v(),u()(A.A,S),A.A&&A.A.locals&&A.A.locals},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use 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