@datagrok/bio 2.16.2 → 2.16.3

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Files changed (8) hide show
  1. package/CHANGELOG.md +6 -0
  2. package/dist/package-test.js +1 -1
  3. package/dist/package-test.js.map +1 -1
  4. package/dist/package.js +1 -1
  5. package/dist/package.js.map +1 -1
  6. package/package.json +2 -2
  7. package/src/utils/monomer-lib/library-file-manager/file-manager.ts +1 -1
  8. package/src/viewers/web-logo-viewer.ts +1 -0
package/dist/package-test.js CHANGED
@@ -4,5 +4,5 @@ var bio_test;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>s});var r=n(7
4
4
  || ${a} === "boolean" || ${s} === null`).assign(c,i._`[${s}]`)}}r.else(),m(e),r.endIf(),r.if(i._`${c} !== undefined`,(()=>{r.assign(s,c),function({gen:e,parentData:t,parentDataProperty:n},r){e.if(i._`${t} !== undefined`,(()=>e.assign(i._`${t}[${n}]`,r)))}(e,c)}))}(e,t,a):m(e)}))}return l};const u=new Set(["string","number","integer","boolean","null"]);function d(e,t,n,r=c.Correct){const s=r===c.Correct?i.operators.EQ:i.operators.NEQ;let o;switch(e){case"null":return i._`${t} ${s} null`;case"array":o=i._`Array.isArray(${t})`;break;case"object":o=i._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":o=a(i._`!(${t} % 1) && !isNaN(${t})`);break;case"number":o=a();break;default:return i._`typeof ${t} ${s} ${e}`}return r===c.Correct?o:(0,i.not)(o);function a(e=i.nil){return(0,i.and)(i._`typeof ${t} == "number"`,e,n?i._`isFinite(${t})`:i.nil)}}function h(e,t,n,r){if(1===e.length)return d(e[0],t,n,r);let s;const o=(0,a.toHash)(e);if(o.array&&o.object){const e=i._`typeof ${t} != "object"`;s=o.null?e:i._`!${t} || ${e}`,delete o.null,delete o.array,delete o.object}else s=i.nil;o.number&&delete o.integer;for(const e in o)s=(0,i.and)(s,d(e,t,n,r));return s}t.checkDataType=d,t.checkDataTypes=h;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?i._`{type: ${e}}`:i._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:r}=e,s=(0,a.schemaRefOrVal)(e,r,"type");return{gen:t,keyword:"type",data:n,schema:r.type,schemaCode:s,schemaValue:s,parentSchema:r,params:{},it:e}}(e);(0,o.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const r=n(9029),s=n(4227);function o(e,t,n){const{gen:o,compositeRule:i,data:a,opts:c}=e;if(void 0===n)return;const l=r._`${a}${(0,r.getProperty)(t)}`;if(i)return void(0,s.checkStrictMode)(e,`default is ignored for: ${l}`);let u=r._`${l} === 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${g(n,s)}`),function(e,t){e.if(d.default.valCxt,(()=>{e.var(d.default.instancePath,u._`${d.default.valCxt}.${d.default.instancePath}`),e.var(d.default.parentData,u._`${d.default.valCxt}.${d.default.parentData}`),e.var(d.default.parentDataProperty,u._`${d.default.valCxt}.${d.default.parentDataProperty}`),e.var(d.default.rootData,u._`${d.default.valCxt}.${d.default.rootData}`),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`${d.default.valCxt}.${d.default.dynamicAnchors}`)}),(()=>{e.var(d.default.instancePath,u._`""`),e.var(d.default.parentData,u._`undefined`),e.var(d.default.parentDataProperty,u._`undefined`),e.var(d.default.rootData,d.default.data),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`{}`)}))}(e,s),e.code(o)})):e.func(t,u._`${d.default.data}, ${function(e){return u._`{${d.default.instancePath}="", ${d.default.parentData}, ${d.default.parentDataProperty}, ${d.default.rootData}=${d.default.data}${e.dynamicRef?u._`, 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n=u.str`${r}/$comment`,s=e.scopeValue("root",{ref:t.root});e.code(u._`${d.default.self}.opts.$comment(${o}, ${n}, ${s}.schema)`)}}function E(e,t,n,r){const{gen:s,schema:a,data:c,allErrors:l,opts:h,self:m}=e,{RULES:f}=m;function g(p){(0,o.shouldUseGroup)(a,p)&&(p.type?(s.if((0,i.checkDataType)(p.type,c,h.strictNumbers)),T(e,p),1===t.length&&t[0]===p.type&&n&&(s.else(),(0,i.reportTypeError)(e)),s.endIf()):T(e,p),l||s.if(u._`${d.default.errors} === ${r||0}`))}!a.$ref||!h.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(h.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{C(e.dataTypes,t)||S(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const r of e.dataTypes)C(t,r)?n.push(r):t.includes("integer")&&"number"===r&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&S(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const r in n){const s=n[r];if("object"==typeof s&&(0,o.shouldUseRule)(e.schema,s)){const{type:n}=s.definition;n.length&&!n.some((e=>{return r=e,(n=t).includes(r)||"number"===r&&n.includes("integer");var n,r}))&&S(e,`missing type "${n.join(",")}" for keyword "${r}"`)}}}(e,e.dataTypes))}(e,t),s.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):s.block((()=>P(e,"$ref",f.all.$ref.definition)))}function T(e,t){const{gen:n,schema:r,opts:{useDefaults:s}}=e;s&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,o.shouldUseRule)(r,n)&&P(e,n.keyword,n.definition,t.type)}))}function C(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function S(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(w(e),y(e))?function(e){const{schema:t,opts:n,gen:r}=e;f(e,(()=>{n.$comment&&t.$comment&&A(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),r.let(d.default.vErrors,null),r.let(d.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),v(e),function(e){const{gen:t,schemaEnv:n,validateName:r,ValidationError:s,opts:o}=e;n.$async?t.if(u._`${d.default.errors} === 0`,(()=>t.return(d.default.data)),(()=>t.throw(u._`new 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c.SchemaEnv({schema:e,schemaId:i,meta:t,baseId:n,localRefs:l}),this._cache.set(a.schema,a),s&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),r&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):c.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{c.compileSchema.call(this,e)}finally{this.opts=t}}}function E(e,t,n,r="error"){for(const s in e){const o=s;o in t&&this.logger[r](`${n}: option ${s}. ${e[o]}`)}}function T(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function C(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function S(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function 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5
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6
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Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?B:"directed"===e.type?W:j;d(i(t),"NodeDataClass",r);var s="geid_"+we()+"_",o=0;return d(i(t),"_attributes",{}),d(i(t),"_nodes",new Map),d(i(t),"_edges",new Map),d(i(t),"_directedSize",0),d(i(t),"_undirectedSize",0),d(i(t),"_directedSelfLoopCount",0),d(i(t),"_undirectedSelfLoopCount",0),d(i(t),"_edgeKeyGenerator",(function(){var e;do{e=s+o++}while(t._edges.has(e));return e})),d(i(t),"_options",e),Ae.forEach((function(e){return d(i(t),e,t[e])})),h(i(t),"order",(function(){return t._nodes.size})),h(i(t),"size",(function(){return t._edges.size})),h(i(t),"directedSize",(function(){return t._directedSize})),h(i(t),"undirectedSize",(function(){return t._undirectedSize})),h(i(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(i(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(i(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(i(t),"multi",t._options.multi),h(i(t),"type",t._options.type),h(i(t),"allowSelfLoops",t._options.allowSelfLoops),h(i(t),"implementation",(function(){return"graphology"})),t}t(r,n);var s=r.prototype;return s._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},s.hasNode=function(e){return this._nodes.has(""+e)},s.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);return!!s&&s.out.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);return!!s&&s.undirected.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new V("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},s.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},s.edge=function(e,t){if(this.multi)throw new Y("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},s.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},s.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},s.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},s.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},s.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},s.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},s.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},s.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},s.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},s.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},s.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},s.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},s.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},s.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},s.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},s.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},s.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},s.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},s.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},s.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},s.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},s.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},s.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},s.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},s.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new U('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,s=n.target.key;if(e===r)return s;if(e===s)return r;throw new U('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(s,")."))},s.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new U('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},s.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},s.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},s.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},s.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new V('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new Y('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},s.mergeNode=function(e,t){if(t&&!l(t))throw new V('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},s.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new V('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var s=t?t({}):{};return n=new this.NodeDataClass(e,s),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:s}),[e,!0]},s.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new U('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var s in n.in){t=n.in[s];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},s.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new U('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new U('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},s.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new U('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},s.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new U('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},s.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},s.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},s.getAttribute=function(e){return this._attributes[e]},s.getAttributes=function(){return this._attributes},s.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},s.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},s.updateAttribute=function(e,t){if("function"!=typeof t)throw new V("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},s.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},s.replaceAttributes=function(e){if(!l(e))throw new V("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},s.mergeAttributes=function(e){if(!l(e))throw new V("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},s.updateAttributes=function(e){if("function"!=typeof e)throw new V("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},s.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,s=this._nodes.values();!0!==(n=s.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},s.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,s,o,i=this._edges.values();!0!==(n=i.next()).done;)s=(r=n.value).source,o=r.target,r.attributes=e(r.key,r.attributes,s.key,o.key,s.attributes,o.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},s.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},s.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},s.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},s.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},s.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},s.forEachNode=function(e){if("function"!=typeof e)throw new V("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},s.findNode=function(e){if("function"!=typeof e)throw new V("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},s.mapNodes=function(e){if("function"!=typeof e)throw new V("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),s=new Array(this.order),o=0;!0!==(t=r.next()).done;)n=t.value,s[o++]=e(n.key,n.attributes);return s},s.someNode=function(e){if("function"!=typeof e)throw new V("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},s.everyNode=function(e){if("function"!=typeof e)throw new V("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},s.filterNodes=function(e){if("function"!=typeof e)throw new V("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),s=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&s.push(n.key);return s},s.reduceNodes=function(e,t){if("function"!=typeof e)throw new V("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new V("Graph.reduceNodes: missing initial value. 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Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(j.TYPE)&&-1!==e.indexOf(j.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,j.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<j.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,j.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,j.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+j.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=j.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Q extends Z{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const s=t[1];if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class J{constructor(){}static getInstance(e){if(J.isMolfileV2K(e))return new X(e);if(J.isMolfileV3K(e))return new Q(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return X.isValidMolfile(e)}static isMolfileV3K(e){return Q.isValidMolfile(e)}}var ee=n(6197),te=n(9124),ne=n(3527),re=n(3629);class se{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",r=void 0,s=void 0,o=void 0,i){if(this.biotype=e,this.id=t,this.n=n,this.m=r,this.type=s,this.mt=o,this.smiles=i,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++se.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class oe extends se{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class ie extends se{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class ae extends se{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class ce extends se{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class le{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,r,s,o,i,a){this.id=e,this.m=t,this.n=n,this.na=r,this.type=s,this.mt=o,this.at=i,this.smiles=a}static fromMonomer(e,t,n){let r={};const s=t.symbol,o=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{r[e.label]=e.capGroupName}));else{if(!o){if(t.lib)return new ce(e,s);throw new Error("Unexpected missing monomer without .lib")}r=n.getRS(o)}const i=new le(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,r),a=n.getMonomerColors(e,t.symbol);return a&&(i.textcolor=a?.textcolor,i.linecolor=a?.linecolor,i.backgroundcolor=a?.backgroundcolor),i}}const ue={[U.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[U.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[U.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[U.o.CHEM]:{R:"#eeeeee"},[U.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},de=/[\w()]+/,he=RegExp(String.raw`\(${de}(,${de})+\)`),pe=new ne.Mi([255,255,255]),me=new ne.Mi([0,0,0]),fe=.7*(0,re.wQ)(pe);class ge{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length))}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t==H._S||t===H.b9[H.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:L().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ye.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}getWebEditorMonomer(e,t){const[n,r]=(0,te.fA)(e,t),s=(0,ee.Y)(n);let o=this.getMonomer(s,r);if(o&&n==U.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==U.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(s,r));let i=o.wem??null;return i||(r===H._S||"*"==r?i=o.wem=new oe(n):n===U.o.NUCLEOTIDE&&"N"===r||n===U.o.AA&&"X"===r||(U.o.CHEM,0)||he.test(r)?i=o.wem=new ie(n,r):o.lib||(i=o.wem=new ae(n,r,this.isEmpty)),i||(i=o.wem=le.fromMonomer(n,o,this))),i}getTooltip(e,t){const n=(0,ee.Y)(e),r=i.div([],{classes:"ui-form ui-tooltip"}),s=this.getMonomer(n,t);if(s){const n=s.symbol,a=(s.name,this.getWebEditorMonomer(e,t));a.backgroundcolor,r.append(i.divH([i.div([n],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:a.textcolor,backgroundColor:a.backgroundcolor,borderColor:a.linecolor,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),i.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const c={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let l;l=s.molfile?o.chem.svgMol(s.molfile,void 0,void 0,c):s.smiles?i.divV([o.chem.svgMol(s.smiles,void 0,void 0,c),i.divText("from smiles",{style:{fontSize:"smaller"}})]):i.divText("No structure",{style:{margin:"6px"}}),r.append(i.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=H._S&&r.append(i.divText(s.lib?.source??"Missed in libraries"))}else r.append(i.divV([i.divText(`Monomer '${t}' of type '${n}' not found.`),i.divText("Open the Context Panel, then expand Manage Libraries")]));return r}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),r=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},s=r(n.textcolor),o=new ne.Mi([...s.map((e=>e+1))]),i=(0,re.KE)(o,pe)/((0,re.wQ)(o)*(0,re.wQ)(pe)),c=r(n.backgroundcolor),l=new ne.Mi([...c.map((e=>e+.01))]);let u;u=(0,re.KE)(l,pe)/((0,re.wQ)(l)*(0,re.wQ)(pe))<i?c:s;let d=new ne.Mi(u);const h=(0,re.wQ)(d);return h>fe&&(d=(0,re.dC)(me,d,fe/h)),`rgb(${d[0]}, ${d[1]}, ${d[2]})`}getMonomerColors(e,t){const n="default";let r=n;const s=(0,ee.Y)(e),o=this.getMonomer(s,t);let i;if(o){if(o.meta&&o.meta.colors){const e=o.meta.colors;n in e||(r="default"),i=e[r]}if(!i){const t=ue[e],n=t?.[o.symbol];n&&(i={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=o.naturalAnalog;if(!i&&t)return this.getMonomerColors(e,t)}return i||(i={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:i.text??i.textColor,linecolor:i.line??i.lineColor,backgroundcolor:i.background??i.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let r,s="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){r=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(s+=t[e][n]);n["R"+r]=s,s=""}return n}}var ye=n(5488),be={};be.styleTagTransform=v(),be.setAttributes=g(),be.insert=m().bind(null,"head"),be.domAPI=h(),be.insertStyleElement=b(),u()(ye.A,be),ye.A&&ye.A.locals&&ye.A.locals;class we extends ge{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?.[n]??null}else{Ye.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=(0,ee.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=J.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,F.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const s=e.duplicateMonomerPreferences[n][r],o=this.duplicateMonomers[n][r].find((e=>e.lib?.source===s));o?this._monomers[n][r]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of L().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}override(e,t){return new ve(e,t,this)}}class ve extends ge{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Ae=n(9192);class Ee{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,s){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=s;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,Ae.AP)(e);this.error=t,this.monomers=[]}}}class Te{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var Ce=n(7433),Se=n.n(Ce),_e=n(1913),Pe=n.n(_e);class Ne{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Se())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Pe()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const s of e){const e=s.symbol??s.id??s.name??"#N/A";if(n=this.validateMonomerSchema(s),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,s,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${s.polymerType??""}-${e}`;r.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(o)}return n}}var Me=n(8604);class xe{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++xe.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await o.dapi.files.readAsText(Me.gt),s=JSON.parse(r),i=new Ne(s);return new xe(i,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists(Me.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText(Me.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists(Me.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete(Me.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists(Me.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),s=await r.readAsText(t);n=JSON.parse(s);const o={},i=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;i.includes(t)||(o[t]={},i.push(t)),o[t][n]=e})),new we(o,t)}async loadSetFromFile(e,t,n){let r={};const s=new a.FileSource(t),o=await s.readAsText(n);r=JSON.parse(o);const i=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,s=n.polymerType,o=n.monomerType,i=n.set;return new Ee(e,r,s,o,i)}));return new Te(i,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(Me.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${Me.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ye.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ye.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ye.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText(Me.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ye.logger.debug(`${e}, OUT`)})),Ye.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(Me.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Me.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(Me.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Me.Es.length)))}}class $e{constructor(){}static _instance;static getInstance(){return $e._instance||($e._instance=new $e),$e._instance}_libFilesUpdateSubject$=new c.BehaviorSubject([]);_setFilesUpdateSubject$=new c.BehaviorSubject([]);_addLibraryFilesSubject$=new 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A.meta.units=o.Hi.SEPARATOR,A.setTag(o.gp.separator,a.J.SEPARATOR),A.setTag(o.gp.aligned,"SEQ.MSA"),A.setTag(o.gp.alphabet,o.YI.UN),A.setTag(o.gp.alphabetIsMultichar,"true"),A.semType=s.SEMTYPE.MACROMOLECULE,A}async function p(e,t,n,s,o,i){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},l=`/align?method=${n}&gap_open=${s}&gap_extend=${o}`;let u;if("fetchProxy"in r.dapi.docker.dockerContainers){const t=window.performance.now(),n=await r.dapi.docker.dockerContainers.fetchProxy(e,l,a),s=window.performance.now();c._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${s-t} ms`);const o="application/json"===n.headers.get("content-type");if(!n.ok&&o){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const r=e["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`);throw new Error(n.statusText)}if(!n.ok&&!o){const e=await n.text();throw new Error(`Error: ${e}`)}if(!o){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await r.dapi.docker.dockerContainers.request(e,l,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const s=u["datagrok-error"];if(s)throw new Error(`Datagrok error: ${s}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];i?.warning(e)}return u}},3890:(e,t,n)=>{"use strict";n.d(t,{aS:()=>a,wz:()=>i}),n(6082),n(7389),n(4328);var r=n(1991),s=n.n(r);n(4374);const o=60;function i(e,t,n=o,r="\n"){const s=[];for(let o=0;o<t.length;o++){const i=e.map((e=>e.get(o).toString())).join("|"),c=a(t.getSplitted(o),n);s.push(`>${i}${r}`);for(const e of c)s.push(`${e}${r}`)}return"".concat(...s)}function a(e,t=o){let n=0;const r=e.length,i=[];for(;n<r;){const r=s().count(n).take(Math.min(e.length-n,t)).map((t=>e.getOriginal(t))).toArray(),o=r.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");i.push(o),n+=r.length}return i}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var r=n(4328),s=n(6077),o=n(2003),i=n(8312),a=n(310),c=n(966),l=n(330);async function u(e,t,n,u,d,h,p){let m;if(n){const n=await(0,i.Q)(),r=n.getSeqHandler(t);let s,a;r.isHelm()?s=t:(a=t.name,t.name=`__${a}`,s=r.convert(o.Hi.HELM),s.name=a,e.columns.add(s,!1));try{m=await n.helmToAtomicLevel(s,!0,!0)}finally{s!==t&&(e.columns.remove(s.name),t.name=a)}}else{if(!(0,c.l)(t,"To Atomic Level",h)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,s.C4)(e,t,d,h,p)}if(m.molCol){const n=(0,l.qj)(e,t.name);m.molCol.name=n,e.columns.add(m.molCol,!0),(0,a.Qc)(t,m.molCol,d,h,p),m.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await r.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";function r(e,t){e.innerHTML="",e.append(t)}n.d(t,{K:()=>r}),n(4328),n(6082)},8047:(e,t,n)=>{"use strict";n.d(t,{VN:()=>m,n5:()=>l,Ue:()=>p,Tc:()=>h,eN:()=>f}),n(4328),n(7389);var r=n(6082),s=(n(1757),n(1991),n(1858),n(2003)),o=n(4326);n(8070),n(7602);var i=n(439),a=n(6882);var c,l,u,d=n(2174);n(4374),HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class h{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class p{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,r){this.pos=e,this.name=t,this._freqs=n??{},r?.sumRowCount&&(this.sumRowCount=r.sumRowCount),r?.sumValueForHeight&&(this.sumPlotValue=r.sumValueForHeight),r?.label&&(this._label=r.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new h),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===o.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const r=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-r*Math.log2(r)}}else if(e===o.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,s,a,c,l,u,d){const h=s===o.fH.Entropy?n*(a-this.sumPlotValueForHeight)/a:n;let p=d*u+(n-h-1);const m=Object.entries(this._freqs).sort(((e,t)=>e[0]!==i._S&&t[0]!==i._S?t[1].value-e[1].value:e[0]===i._S&&t[0]===i._S?0:e[0]===i._S?-1:1));for(const[n,s]of m){const n=h*s.plotValue/this.sumPlotValue;s.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,o,c){for(const[l,u]of Object.entries(this._freqs))if(l!==i._S){const i=(0,s.zS)(l,5),d=u.bounds,h=d.left;let p=a.S$;c&&(p=c.getMonomerTextColor(o,l)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(h,d.top,d.width,d.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(i);e.setTransform(d.width/m.width,0,0,d.height/r,h,d.top),e.fillText(i,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,d.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(c||(c={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(l||(l={})),o.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(u||(u={}));const m=new class{render=20};function f(e,t,n,r,s){let o=0,i=-1;for(;-1!=(i=n.findNext(i,!0));){const e=t.getSplitted(i),n=s.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&o++}return o}r.JsViewer},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>i,n:()=>o});var r=n(1858),s=n(4374);class o{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(s._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class i{onChanged=new r.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>C,AR:()=>T});var r=n(7389),s=n(6082),o=n(4328),i=n(1991),a=n.n(i),c=n(1858),l=n(2003),u=n(8070),d=n(7602),h=n(8115),p=n(4577),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),w=n(4374);class v extends p.O{seqHelper;emptyProps=new p.n("");helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}})).onCancel((()=>{f()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),s=this._filterPanel;s.innerText="error",s.classList.add("d4-error"),r.tooltip.bind(s,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,b.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,h.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class E{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,s){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=s}}class T extends p.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class C extends s.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new d.g(this.logger)}static filterCounter=-1;filterId=++C.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(s.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new S:this.notation===l.Hi.SEPARATOR?new _(this.column.getTag(l.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(s.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=s.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(A,new E(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class S extends p.O{emptyProps=new p.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,h.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class _ extends p.O{emptyProps=new T("",void 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n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await e.loadMonomerLibForTests(),function(e,n){const r=n,s=e.getSummaryObj();for(const e in r)r[e]||delete r[e];for(const e in s)s[e]||delete s[e];if(0==Object.keys(r).length&&0!=Object.keys(s).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(r).length&&0==Object.keys(s).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(s,r),(0,t.Xk)(r,s)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(r)} does not match actual ${JSON.stringify(s)}.`)}}(e.getMonomerLib(),$.VV)})),(0,t.t6)("empty",(async()=>{const n=await(0,N.ub)(),r=await e.getFileManager();let s=r.getValidLibraryPaths();0===s.length&&(s=await r.getValidLibraryPathsAsynchronously()),n.exclude=s,n.explicit=[],await(0,N.Eu)(n),await e.loadMonomerLib(!0);const o=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===o.length,!0)})),(0,t.t6)("override",(async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},r=e.getMonomerLib(),s=r.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null===s,!0,`Unexpectedly found monomer '${n.symbol}' `);const o=r.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);(0,t.Xk)(o,n)}))}));var L=n(7389),I=n(1757),R=n.n(I),O=n(1858),k=n(6873),G=n(5433);async function D(n,r){const s=n(),o=e.DataFrame.fromColumns(s);await a.data.detectSemanticTypes(o);const i=Date.now(),c=(o.columns.byName("MSA"),a.shell.addTableView(o));await _(c.grid),(0,t.E3)(c.grid.dataFrame.id,o.id);const l=Date.now()-i;console.log(`Performance test: ${r}: ${l}ms`)}(0,t.L1)("renderers",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),(0,t.t6)("long sequence performance ",(async()=>{await D(k.dW,"Long sequences")})),(0,t.t6)("many sequence performance",(async()=>{await D(k.fD,"Many sequences")})),(0,t.t6)("rendererMacromoleculeFasta",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),s=r.getCol("Sequence"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=s.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),s=r.getCol("sequence"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=s.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),s=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(s.grid),(0,t.E3)(s.grid.dataFrame.id,r.id);const o=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(o,P.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),s=(await a.functions.call("Bio:importFasta",{fileContent:r}))[0],o=s.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:o});i&&(o.semType=i);const l=a.shell.addTableView(s);await a.data.detectSemanticTypes(s),console.log("Bio: tests/renderers/afterMsa, table view"),await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${o.semType}", units="${o.meta.units}", cell.renderer="${o.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(o.meta.units,c.Hi.FASTA),(0,t.E3)(o.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(o.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(o.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,y.D)({col:o},n);await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),s=e.DataFrame.fromCsv(r),o=s.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:o});i&&(o.semType=i);const l=a.shell.addTableView(s);await a.data.detectSemanticTypes(s);const u=await(0,G.r)(o,n,c.Hi.SEPARATOR,"/");await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id);const d=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const r=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),s=a.shell.addTableView(r);await _(s.grid);const o=r.getCol("sequence"),i=n.getSeqHandler(o).convert(c.Hi.HELM);r.columns.add(i),await _(s.grid),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const s=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==s)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${s}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const n=e.DataFrame.fromCsv(r);n.currentRowIdx=0;const s=a.shell.addTableView(n),o=n.plot.scatter({x:"x",y:"y"});s.dockManager.dock(o,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(o.onAfterDrawScene,(()=>{}),(()=>{o.invalidateCanvas()}),1e3),_(s.grid,500)]);const i=o.root.getBoundingClientRect(),c=o.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:i.left+c.x,clientY:i.top+c.y}),u=R()(o.root).find("canvas").get()[0];await(0,t.PE)((0,O.fromEvent)(u,"mousemove"),(()=>{Se.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(R()(L.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(o.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await _(s.grid,500)}()}));const r="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var H=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,T.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const s={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(s))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),s=new H.Jy(null,n,Se.logger,3,(()=>({monomerCharWidth:7,separatorWidth:12,monomerToShort:c.zS})));await s.init();const o=r.testList;for(let e=0;e<n.length;++e)s.getCellMonomerLengths(e,1e4);const i=[];for(const[e,t]of A().enumerate(o)){const t={pos:s.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&i.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(i.length>0)throw new Error("Test failed error(s):\n"+i.join(", \n"))}));const o=[10,20,30,40,50,60],i={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(i))(0,t.t6)("hitBounds-"+e,(async()=>{const e=(0,H.Bb)(o,n.x);(0,t.E3)(e,n.tgt)}))})),(0,t.L1)("converters",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,l.Q)()})),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(r||(r={}));const s={[r.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[r.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[r.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[r.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[r.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[r.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[r.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[r.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[r.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[r.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[r.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[r.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[r.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[r.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[r.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[r.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[r.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[r.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},o=new Set(Object.values(c.gp));async function i(t){const n=s[t],r=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(r),r}function u(e,r){if(e===c.Hi.SEPARATOR&&!r)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(s){const o=n.getSeqHandler(s).convert(e,r);return(0,t.E3)(o.meta.units,e),o}}async function d(e,r,s){const a=(await i(e)).getCol("seq"),l=r(a),u=(await i(s)).getCol("seq");(0,t.J6)(l.toList(),u.toList());const d=n.getSeqHandler(a),h=n.getSeqHandler(l);for(const[e,n]of Object.entries(u.tags)){if(!o.has(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const r=l.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await 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n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function s(e){const s=new F.m(e),o=s.descriptionsArray,i=s.sequencesArray;(0,t.J6)([o,i],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{s(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{s(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n 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i.awaitRendered()})),(0,t.t6)("positions with shrinkEmptyTail option true (filtered)",(async()=>{const n=e.DataFrame.fromCsv("seq\n-TC-G-TTGC--\n-TC-GCTTGC--\n-T--C-GT-\n-T--C-GT-\n-T--C-GT-\n-T--CCGT-"),r=a.shell.addTableView(n),s=n.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.DNA),s.setTag(c.gp.aligned,"SEQ"),n.filter.init((e=>e>2)),n.filter.fireChanged();const o=await n.plot.fromType("WebLogo",{shrinkEmptyTail:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const i=o.positions,l=[new W.Ue(0,"1",{[j]:new W.Tc(3)}),new W.Ue(1,"2",{T:new W.Tc(3)}),new W.Ue(2,"3",{[j]:new W.Tc(3)}),new W.Ue(3,"4",{[j]:new W.Tc(3)}),new W.Ue(4,"5",{C:new W.Tc(3)}),new W.Ue(5,"6",{[j]:new W.Tc(2),C:new W.Tc(1)}),new W.Ue(6,"7",{G:new W.Tc(3)}),new W.Ue(7,"8",{T:new W.Tc(3)}),new W.Ue(8,"9",{[j]:new W.Tc(3)})];(0,t.E3)(i.length,l.length);for(let e=0;e<i.length;e++){(0,t.E3)(i[e].name,l[e].name);for(const n of i[e].getMonomers())(0,t.E3)(i[e].getFreq(n).rowCount,l[e].getFreq(n).rowCount)}await o.awaitRendered()})),(0,t.t6)("positions with skipEmptyPositions option",(async()=>{const n=e.DataFrame.fromCsv(r),s=a.shell.addTableView(n),o=n.getCol("seq");o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=c.Hi.FASTA,o.setTag(c.gp.alphabet,c.YI.DNA),o.setTag(c.gp.aligned,"SEQ.MSA");const i=await n.plot.fromType("WebLogo",{skipEmptyPositions:!0});await(0,t.PE)(i.onLayoutCalculated,(()=>{}),(()=>{s.dockManager.dock(i.root,e.DOCK_TYPE.DOWN)}),500);const l=i.positions,u=[new W.Ue(0,"1",{A:new W.Tc(2),[j]:new W.Tc(3)}),new W.Ue(1,"2",{T:new W.Tc(5)}),new W.Ue(2,"3",{C:new W.Tc(5)}),new W.Ue(4,"5",{G:new W.Tc(5)}),new W.Ue(5,"6",{[j]:new W.Tc(3),C:new W.Tc(2)}),new W.Ue(6,"7",{T:new W.Tc(5)}),new W.Ue(7,"8",{T:new W.Tc(5)}),new W.Ue(8,"9",{G:new W.Tc(5)}),new W.Ue(9,"10",{C:new W.Tc(5)})];(0,t.E3)(l.length,u.length);for(let e=0;e<l.length;e++)K(l[e],u[e]);await i.awaitRendered()})),(0,t.t6)("count sequences for monomer at position",(async()=>{const s=function(t,n,r){const s=e.DataFrame.fromCsv(t),o=s.getCol("seq");return o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=n,o.setTag(c.gp.alphabet,r),o.setTag(c.gp.aligned,"SEQ.MSA"),s}(r,c.Hi.FASTA,c.YI.DNA),o=s.getCol("seq"),i=a.shell.addTableView(s),l=await s.plot.fromType("WebLogo",{startPositionName:"3",endPositionName:"7",skipEmptyPositions:!0});await(0,t.PE)(l.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(l.root,e.DOCK_TYPE.DOWN)}),500);const u=l.positions,d=[new W.Ue(2,"3",{C:new W.Tc(5)}),new W.Ue(4,"5",{G:new W.Tc(5)}),new W.Ue(5,"6",{[j]:new W.Tc(3),C:new W.Tc(2)}),new W.Ue(6,"7",{T:new W.Tc(5)})];(0,t.E3)(u.length,d.length);for(let e=0;e<u.length;e++)K(u[e],d[e]);const h=u[1],p=n.getSeqHandler(o),m=(0,W.eN)(s,p,s.filter,"G",h);(0,t.E3)(m,5),await l.awaitRendered()})),(0,t.t6)("empty",(async()=>{const n=e.DataFrame.fromColumns([(()=>{const 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a.dapi.projects.save(o)}(n,r.getTableInfo(),i,r),a.shell.closeAll(),await(0,t.cb)(500),await a.dapi.projects.open(n);const l=a.shell.getTableView(s),u=A()(l.viewers).toArray();(0,t.E3)(u.length,2),(0,t.E3)(u.filter((e=>"Grid"===e.type)).length,1);const d=u.find((e=>"WebLogo"===e.type));(0,t.E3)(!!d,!0),await _(i.grid),await d.awaitRendered()}),{skipReason:"depends on 1.18"})})),(0,t.L1)("WebLogo.layout",(()=>{(0,t.t6)("fasta",(async()=>{const e=await Se.files.readCsv("tests/filter_FASTA.csv"),n=e.getCol("fasta");await a.data.detectSemanticTypes(e);const r=a.shell.addTableView(e),s=await e.plot.fromType("WebLogo",{sequenceColumnName:n.name});r.dockManager.dock(s),await(0,t.cb)(2*W.VN.render),await s.awaitRendered(),await _(r.grid);const o=r.saveLayout();o.toJson(),r.loadLayout(o),await(0,t.cb)(2*W.VN.render),await s.awaitRendered(),await _(r.grid);const i=A()(r.viewers).toArray();(0,t.E3)(i.length,2),(0,t.E3)(i.filter((e=>"Grid"===e.type)).length,1),(0,t.E3)(i.filter((e=>"WebLogo"===e.type)).length,1)}))}));var q=n(966);function z(e,t){let n=null;for(const r of e.viewers)r.type===t&&(n=r);return n}(0,t.L1)("checkInputColumn",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r="seq\nseq1,\nseq2,\nseq3,\nseq4";(0,t.t6)("testMsaPos",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.DNA),s.setTag(c.gp.aligned,"SEQ");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!0)})),(0,t.t6)("testMsaNegHelm",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.HELM,s.setTag(c.gp.alphabetIsMultichar,"true");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!1)})),(0,t.t6)("testMsaNegUN",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,"UN"),s.setTag(c.gp.alphabetSize,"11"),s.setTag(c.gp.alphabetIsMultichar,"true"),s.setTag(c.gp.aligned,"SEQ");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!1)})),(0,t.t6)("testGetActionFunctionMeta",(async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find((e=>"sequence"==e.name))}))})),(0,t.L1)("similarity/diversity",(async()=>{(0,t.t6)("similaritySearchViewer",(async()=>{await async function(){const n=await Se.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(r);const s=a.shell.addTableView(r),o=s.dataFrame.getCol("MSA");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const i=await s.dataFrame.plot.fromType("Sequence Similarity Search");let c=!1;if(i.computeCompleted.subscribe((e=>{e&&(c=!0)})),s.dockManager.dock(i,e.DOCK_TYPE.RIGHT,null,"Similarity"),await i.renderPromise,await(0,t.bk)((()=>void 0!==z(s,"Sequence Similarity Search")),"Sequence Similarity Search viewer has not been created",100),!i.initialized)throw new Error("The viewer is not initialized.");if(!i.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!i.beforeRender())throw new Error("The viewer is not able to render.");if(!i.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=i;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Similarity Search viewer grid has not been created",100);(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.scores.get(0),e.FLOAT_NULL),(0,t.E3)(l.idxs.get(0),0),(0,t.E3)(l.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(l.scores.get(1).toFixed(2),"0.73"),(0,t.E3)(l.idxs.get(1),4),(0,t.E3)(l.molCol.get(1),"Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"),s.dataFrame.currentRowIdx=1,await(0,t.bk)((()=>1===l.targetMoleculeIdx),"Target molecule has not been changed",5e3),await(0,t.bk)((()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===l.molCol.get(0)),"Incorrect first similar molecule",5e3)}()})),(0,t.t6)("diversitySearchViewer",(async()=>{await async function(){const n=await Se.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n),s=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const o=s.dataFrame.getCol("MSA");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const i=await s.dataFrame.plot.fromType("Sequence Diversity Search");let c=!1;if(i.computeCompleted.subscribe((e=>{e&&(c=!0)})),s.dockManager.dock(i,e.DOCK_TYPE.DOWN,null,"Diversity"),await i.renderPromise,await(0,t.bk)((()=>void 0!==z(s,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!i.initialized)throw new Error("The viewer is not initialized.");if(!i.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!i.beforeRender())throw new Error("The viewer is not able to render.");if(!i.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=i;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.initialized,!0),(0,t.E3)(l.renderMolIds.length>0,!0)}()}))}));var Z=n(1687),X=n(4577);(0,t.L1)("bio-substructure-filters",(async()=>{let n,r,s;async function o(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const r=new Z._i(n,Se.logger);return r.attach(t),r.applyState({columnName:e}),r.column=t.col(e),r.columnName=e,r}(0,t.gM)((async()=>{n=await(0,l.Q)(),r=await(0,T.pj)(),s=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await r.loadMonomerLib(!0)})),(0,t.t6)("fasta",(async()=>{const e=await S("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const r=new Z._i(n,Se.logger);r.attach(e),await r.awaitRendered();try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const n=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("MD")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,3),(0,t.E3)(r.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{r.detach()}await r.awaitRendered()})),(0,t.t6)("separator",(async()=>{const e=await S("tests/filter_MSA.csv"),r=new Z._i(n,Se.logger);await a.data.detectSemanticTypes(e),r.attach(e),await r.awaitRendered();try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter");const n=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,7),(0,t.E3)(r.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("/meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("meI-hHis","-")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,7),(0,t.E3)(r.dataFrame.filter.get(2),!1)}finally{r.detach()}await r.awaitRendered()})),(0,t.t6)("helm-dialog",(async()=>{const e="Bio tests: substructureFilters/helm-dialog",r=await S("tests/filter_HELM.csv");await a.data.detectSemanticTypes(r);const s=a.shell.addTableView(r);Se.logger.debug(`${e}, filter attaching.`);const o=new Z._i(n,Se.logger);o.attach(r);const i=L.dialog("Test filters").add(o.root).show();await o.awaitRendered();try{const n=o.bioFilter;(0,t.E3)(null!==o.bioFilter,!0,"bioFilter is not created"),Se.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(r.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("PEPTIDE1{A.C}$$$$V2.0")}),2e4),Se.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(o.dataFrame.filter.trueCount,1),(0,t.E3)(o.dataFrame.filter.toBinaryString(),"0001"),Se.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(r.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("PEPTIDE1{C}$$$$V2.0")}),2e4),await _(s.grid),Se.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(o.dataFrame.filter.trueCount,2),(0,t.E3)(o.dataFrame.filter.toBinaryString(),"1001")}finally{i.close()}await o.awaitRendered(),await(0,t.cb)(3e3)})),(0,t.t6)("helm-view",(async()=>{const e=await S("tests/filter_HELM.csv");e.getCol("HELM string"),await a.data.detectSemanticTypes(e);const t=a.shell.addTableView(e);t.getFiltersGroup(),await _(t.grid)})),(0,t.t6)("sync-fasta",(async()=>{const e=await Se.files.readCsv("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=await o("fasta",e),r=await o("fasta",e);await Promise.all([n.awaitRendered(),r.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const s=n.bioFilter,o=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{s.props=new X.n("MD")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(o.props.substructure,"MD")}finally{n.detach(),r.detach()}await Promise.all([n.awaitRendered(),r.awaitRendered()])})),(0,t.t6)("sync-msa",(async()=>{const e=await Se.files.readCsv("tests/filter_MSA.csv");await a.data.detectSemanticTypes(e);const n="hHis-Aca",r=await o("MSA",e),s=await o("MSA",e);await Promise.all([r.awaitRendered(),s.awaitRendered()]);try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(s.bioFilter.type,"SeparatorBioFilter");const o=r.bioFilter,i=s.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new Z.AR(n,"-")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(i.props.substructure,n),(0,t.E3)(i.props.separator,"-")}finally{r.detach(),s.detach()}await Promise.all([r.awaitRendered(),s.awaitRendered()])})),(0,t.t6)("sync-helm",(async()=>{const e=await Se.files.readCsv("tests/filter_HELM.csv");await a.data.detectSemanticTypes(e);const n=a.shell.addTableView(e),r="PEPTIDE1{A.C}$$$$V2.0",s=await o("HELM string",e),i=await o("HELM string",e),c=L.dialog("Test filters").add(s.root).add(i.root).show();await Promise.all([s.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(s.bioFilter.type,"HelmBioFilter"),(0,t.E3)(i.bioFilter.type,"HelmBioFilter");const o=s.bioFilter,a=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new X.n(r)}),6e4,"await onRowsFiltered"),await _(n.grid),Se.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*s.debounceTime),Se.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,1),await s.awaitRendered(),(0,t.E3)(a.props.substructure,r)}finally{s.detach(),i.detach(),c.close()}await Promise.all([s.awaitRendered(),i.awaitRendered()]),await _(n.grid),await(0,t.cb)(3e3)})),(0,t.t6)("two-columns-fasta",(async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),s="seq1",o="CGGCTG",i=n.getCol("trueSeq1").toList(),c="seq2",l="GCATT",u=n.getCol("trueSeq2").toList(),d=[{type:"Bio:bioSubstructureFilter",columnName:s},{type:"Bio:bioSubstructureFilter",columnName:c}],h=await n.plot.fromType(e.VIEWER.FILTERS,{filters:d});r.dockManager.dock(h,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid);const p=h.filters[0],m=h.filters[1];(0,t.E3)(p.column.name,s),(0,t.E3)(m.column.name,c);const f=p.bioFilter,g=m.bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n(o)}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n("")}),1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,i.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),i.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n(l)}),1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),u.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n("")}),1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n(o)}),5e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n(l)}),5e3,"testEvent onRowsFiltered on both");const y=A().count(0).take(n.rowCount).map((e=>i[e]*u[e])).toArray();(0,t.E3)(n.filter.trueCount,y.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),y.map((e=>e.toString())).join("")),await Promise.all([p.awaitRendered(),m.awaitRendered(),_(r.grid)])})),(0,t.t6)("reset-fasta",(async()=>{const n=await S("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),s="MD",o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid);const i=o.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{i.props=new X.n(s)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(i.props.substructure,s),(0,t.E3)(i.substructureInput.value,s),R()(o.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await _(r.grid),(0,t.E3)(i.props.substructure,""),(0,t.E3)(i.substructureInput.value,"")})),(0,t.t6)("reopen",(async()=>{const n=await Se.files.readCsv("tests/filter_FASTA.csv"),r=a.shell.addTableView(n),s=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:s});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid),o.close(),await _(r.grid);const i=await n.plot.fromType(e.VIEWER.FILTERS,{filters:s});r.dockManager.dock(i,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid)}))}));var Q=n(8152);class J{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var ee=n(9192);(0,t.L1)("PepSeA",(()=>{(0,t.gM)((async()=>{await(0,b.m8)()})),(0,t.t6)("Basic alignment",(async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,Q.GD)(n.getCol("HELM"),"msa(HELM)"),s=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==s.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new J,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),s=await(0,Q.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),o=r.getCol("MSA");(0,t.J6)(s.toList(),o.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")}),{timeout:6e4,stressTest:!0}),(0,t.t6)("error",(async()=>{const n=new J;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,Q.GD)(t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,r]=(0,ee.AP)(e);n.error(t,void 0,r)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")}))})),(0,t.L1)("viewers",(()=>{const n=e.Func.find({package:"Bio",tags:["viewer"]}).map((e=>e.friendlyName));for(const e of n)(0,t.t6)(e,(async()=>{const n=await S("samples/FASTA_DNA.csv");await(0,t.Bl)(e,n,{detectSemanticTypes:!0})}),{skipReason:{"Sequence Similarity Search":"GROK-13162","Sequence Diversity Search":"GROK-13162",WebLogo:"GROK-13162",VdRegions:"GROK-13162"}[e]})}));const te="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",ne="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",re="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var se;(0,t.L1)("SeqHandler",(()=>{let n;async function r(t){const r=e.DataFrame.fromCsv(t);await a.data.detectSemanticTypes(r);const s=n.getSeqHandler(r.getCol("seq"));return[r,s]}(0,t.gM)((async()=>{n=await(0,l.Q)()})),(0,t.t6)("Seq-Fasta",(async()=>{const[e,n]=await r(te);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA",(async()=>{const[e,n]=await r(ne);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)})),(0,t.t6)("Seq-Fasta-units",(async()=>{const[e,n]=await r(te);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA-units",(async()=>{const[e,n]=await r(ne);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)})),(0,t.t6)("Seq-Helm",(async()=>{const[e,n]=await r("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(n.notation,c.Hi.HELM),(0,t.E3)(n.isHelm(),!0)})),(0,t.t6)("Seq-UN",(async()=>{const[e,n]=await r(re);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)})),(0,t.t6)("Seq-UN-auto",(async()=>{const[e,n]=await r(re);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)})),(0,t.t6)("column-version",(async()=>{const r=e.DataFrame.fromCsv(te);await a.data.detectSemanticTypes(r);const s=r.getCol("seq"),o=n.getSeqHandler(s),i=s.version,c=n.getSeqHandler(s),l=s.version;(0,t.E3)(i,l,"Unexpected column version changed"),(0,t.E3)(o,c,"Unexpected SeqHandler object changed"),r.rows.addNew(["TACCCCTTCAAC"]);const u=n.getSeqHandler(s),d=s.version;(0,t.E3)(l<d,!0,"Stalled column version on add row"),(0,t.E3)(c!==u,!0,"Stalled SeqHandler object on add row"),s.set(1,"CAGTGTCCCCGT");const h=n.getSeqHandler(s),p=s.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(u!==h,!0,"Stalled SeqHandler object on change data"),s.setTag("testTag","testValue");const m=n.getSeqHandler(s),f=s.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),function(e){e.fasta="fasta",e.fastaMsa="fastaMsa",e.separator="separator",e.separatorMsa="separatorMsa",e.helm="helm"}(se||(se={})),(0,t.L1)("SeqHandler: splitted",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),Y.b9[c.Hi.FASTA],Y.b9[c.Hi.HELM];const r=Y.b9[c.Hi.SEPARATOR],s={[se.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[se.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[se.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[se.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",r,"abc1","dfgg","rut12","her2","rty",r,"abc1","dfgg"],["rut2","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],["rut3","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],[r,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",r]]}},[se.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$"},tgt:{notation:c.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[r,o]of Object.entries(s))(0,t.t6)(`${r}`,(async()=>{const r=e.DataFrame.fromCsv(o.src.csv).getCol("seq"),s=await a.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s),(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const i=n.getSeqHandler(r);(0,t.E3)(i.notation,o.tgt.notation),(0,t.E3)(i.separator===o.tgt.separator,!0);const c=A().count(0).take(i.length).map((e=>{const t=i.getSplitted(e);return A().count(0).take(t.length).map((e=>t.getOriginal(e))).toArray()})).toArray();(0,t.J6)(c,o.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:c.Hi.FASTA,alphabet:c.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:c.Hi.SEPARATOR,alphabet:c.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 3, 4, 4A, 4A, 4C",start:"4",end:null}},helm:{srcCsv:"seq\nPEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn]}$$$$\nPEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro]}$$$$\nPEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T}$$$$",startIdx:3,endIdx:6,tgtCsv:"seq\nPEPTIDE1{N.T.[dE].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.[dK].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.*.*}$$$$",units:c.Hi.HELM,alphabet:null,positionNames:{tag:null,start:"4",end:"7"}}};for(const[s,o]of Object.entries(r))(0,t.t6)(`${s}-idx`,(async()=>{const r=e.DataFrame.fromCsv(o.srcCsv).getCol("seq"),s=await a.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const i=n.getSeqHandler(r).getRegion(o.startIdx,o.endIdx,"regSeq"),l=e.DataFrame.fromCsv(o.tgtCsv).getCol("seq");(0,t.E3)(r.meta.units,o.units),(0,t.E3)(i.meta.units,o.units),(0,t.E3)(r.getTag(c.gp.alphabet),o.alphabet),(0,t.E3)(i.getTag(c.gp.alphabet),o.alphabet),(0,t.J6)(i.toList(),l.toList())})),o.positionNames&&(0,t.t6)(`${s}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(o.srcCsv).getCol("seq");o.positionNames.tag&&n.setTag(c.gp.positionNames,o.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=await a.functions.call("Bio:getRegion",{sequence:n,start:o.positionNames.start,end:o.positionNames.end}),i=e.DataFrame.fromCsv(o.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,o.units),(0,t.E3)(s.meta.units,o.units),(0,t.E3)(n.getTag(c.gp.alphabet),o.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),o.alphabet),(0,t.J6)(s.toList(),i.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r,s;(0,t.gM)((async()=>{n=await(0,l.Q)(),r=await(0,T.pj)(),s=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await r.loadMonomerLib(!0)}));const o={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(o))(0,t.t6)(e,(async()=>{await i(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function i(r,s,o,i){const c=e.Column.fromStrings("seq",[r]),l=e.DataFrame.fromColumns([c]);await a.data.detectSemanticTypes(l);const u=n.getSeqHandler(c),d=(await u.getHelm(0)).value;(0,t.E3)(d,i)}}));var oe=n(6956);class ie{constructor(e){const t=e.split(oe.xe);t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],r=t.split(",");r[2].split("-").forEach(((e,t)=>{const s=r[t],o=e.split(":"),i={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:s,bond:i})})),e.push(n)})),e}}class ae{simplePolymer;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],r=[];return t.forEach((e=>{n.push(e),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const r=t[n],s=t[n+1];e.push([{monomerIdx:r,rGroupId:2},{monomerIdx:s,rGroupId:1}])}for(let t=0;t<n.length;t++){const r=n[t],s=r-1;e.push([{monomerIdx:s,rGroupId:3},{monomerIdx:r,rGroupId:1}])}return e}}class ce{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(oe.pk),n=t[0].split(oe.xe);this.simplePolymers=n.map((e=>new ae(e))),""!==t[1]&&(this.connectionList=new ie(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,r=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(r)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const r=Object.keys(t).find((e=>t[e]===n));return 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e={"single-linear":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T.[meI]}$$$$"},tgt:{simplePolymers:[6],bondedRGroups:[1,2,2,2,2,1]}},"single-cyclized-C-2-2":{src:{helm:"PEPTIDE1{R.F.C.Y.G.H.[GGaz].C.T.[meI]}$PEPTIDE1,PEPTIDE1,3:R3-8,R3$$$"},tgt:{simplePolymers:[10],bondedRGroups:[1,2,3,2,2,2,2,3,2,1]}},"single-cyclized-C-1-1":{src:{helm:"PEPTIDE1{F.C.Y.G.H.[GGaz].C.[meI]}$PEPTIDE1,PEPTIDE1,2:R3-7,R3$$$"},tgt:{simplePolymers:[8],bondedRGroups:[1,3,2,2,2,1,3,1]}},"single-cyclized-C-0-0":{src:{helm:"PEPTIDE1{C.Y.G.H.[GGaz].C}$PEPTIDE1,PEPTIDE1,2:R3-7,R3$$$"},tgt:{simplePolymers:[6],bondedRGroups:[2,2,2,2,2,2]}},"two-separated-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$$$$"},tgt:{simplePolymers:[5,1],bondedRGroups:[1,2,2,2,1,1]}},"two-separated-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$$$$"},tgt:{simplePolymers:[4,2],bondedRGroups:[1,2,2,1,1,1]}},"two-connected-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$PEPTIDE1,PEPTIDE2,5:R2-1,R1$$$"},tgt:{simplePolymers:[5,1],bondedRGroups:[1,2,2,2,2,1]}},"two-connected-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$PEPTIDE1,PEPTIDE2,4:R2-1,R1$$$"},tgt:{simplePolymers:[4,2],bondedRGroups:[1,2,2,2,2,1]}}};for(const[n,{src:r,tgt:s}]of Object.entries(e))(0,t.t6)(n,(async()=>{const e=new ce(r.helm),n=e.simplePolymers.map((e=>e.monomers.length)),o=n.reduce(((e,t)=>e+t),0);(0,t.E3)(n,s.simplePolymers);const i=A().count(0).take(e.bondedRGroupsMap.size).map((t=>e.bondedRGroupsMap.get(t).length)).toArray();(0,t.E3)(o,i.length)}),{skipReason:"new tests"})}));var le=n(6077),ue=n(6717);const de=new e.FileSource("System:AppData/Bio"),he={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},pe="molfile(sequence)";function me(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map((e=>e.trimEnd())).join("\n")}(0,t.L1)("toAtomicLevel",(async()=>{const n={},r={};let s,o,i,u,d,h;async function p(e,n){const r=e.getCol("sequence");await a.functions.call("Bio:toAtomicLevel",{table:e,seqCol:r,nonlinear:!1});const s=e.getCol(pe),o=n.getCol(pe),i=A()(s.values()).map((e=>me(e))).toArray(),c=A()(o.values()).map((e=>me(e))).toArray();(0,t.J6)(i,c)}(0,t.gM)((async()=>{d=await(0,ue.j)(),i=await(0,l.Q)(),s=await(0,T.pj)(),o=await(0,N.ub)(),await s.loadMonomerLibForTests(),u=s.getMonomerLib();for(const[t,s]of Object.entries(he))s.inPath,n[t]=e.DataFrame.fromCsv((await de.readAsText(s.inPath)).replace(/\n$/,"")),await a.data.detectSemanticTypes(n[t]),r[t]=e.DataFrame.fromCsv((await de.readAsText(s.outPath)).replace(/\n$/,""))})),(0,t.Pl)((async()=>{await(0,N.Eu)(o),await s.loadMonomerLib(!0)}));for(const[e,s]of Object.entries(he))(0,t.t6)(`${e}`,(async()=>{await p(n[e],r[e])}));!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(h||(h={}));const m={[h.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[h.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[h.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[h.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[h.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[h.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[h.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[h.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[h.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function f(t){const n=m[t],r=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await a.data.detectSemanticTypes(r),r}async function g(e,t="seq",n){const r=e.getCol(t),s=await(0,le.C4)(e,r,u,i,d);return s.warnings.length>0&&Se.logger.warning(`_toAtomicLevel() warnings ${s.warnings.join("\n")}`),s.molCol}(0,t.t6)("fastaDna",(async()=>{await g(await f(h.fastaDna),"seq")})),(0,t.t6)("fastaRna",(async()=>{await g(await f(h.fastaRna),"seq")})),(0,t.t6)("fastaPt",(async()=>{await g(await f(h.fastaPt),"seq")})),(0,t.t6)("fastaUn",(async()=>{await g(await f(h.fastaUn),"seq")})),(0,t.t6)("separatorDna",(async()=>{await g(await f(h.separatorDna),"seq")})),(0,t.t6)("separatorDna",(async()=>{await g(await f(h.separatorRna),"seq")})),(0,t.t6)("separatorPt",(async()=>{await g(await f(h.separatorPt),"seq")})),(0,t.t6)("separatorUn",(async()=>{await g(await f(h.separatorUn),"seq")})),(0,t.t6)("helm",(async()=>{await g(await f(h.helm),"seq")})),(0,t.t6)("ptFasta2",(async()=>{const n=await Se.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),r=e.DataFrame.fromCsv("seq\nAR"),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.PT),i.getSeqHandler(s);const o=await g(r,"seq");(0,t.E3)(me(o.get(0)),me(n))}))}));var fe=n(8754);(0,t.L1)("toAtomicLevel-ui",(()=>{let n,r,s,o,i;(0,t.gM)((async()=>{s=await(0,l.Q)(),i=await(0,ue.j)(),n=await(0,T.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests(),o=n.getMonomerLib()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const u={fasta:{src:{seq:"MDYKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},"fasta-with-gap":{src:{seq:"MD-YKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},helm:{src:{seq:"PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}},"helm-with-gap":{src:{seq:"PEPTIDE1{meI.hHis.*.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}}},d=async t=>{const n=t.src.seq,r=e.DataFrame.fromColumns([e.Column.fromList(e.COLUMN_TYPE.STRING,"seq",[n])]);return await a.data.detectSemanticTypes(r),r.getCol("seq")};for(const[e,n]of Object.entries(u))(0,t.t6)(`${e}-linear`,(async()=>{const e=await d(n);await h(e,!1,n.tgt)}));for(const[e,n]of Object.entries(u))(0,t.t6)(`${e}-nonlinear`,(async()=>{const e=await d(n);await h(e,!0,n.tgt)}));async function h(n,r,a){const c=await(0,fe.V)(n.dataFrame,n,r,!1,o,s,i);(0,t.E3)(c.molCol.semType,e.SEMTYPE.MOLECULE);const l=c.molCol.get(0),u=i.get_mol(l);(0,t.E3)(null!=u,!0,"No molecule generated");try{const e=u.get_num_atoms(),n=u.get_num_bonds();(0,t.E3)(e,a.atomCount),(0,t.E3)(n,a.bondCount)}finally{u.delete()}}}));var ge=n(6863);async function ye(t,n){const r=e.DataFrame.fromCsv(t),s=r.col("seq"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});return o&&(s.semType=o),await a.data.detectSemanticTypes(r),n.getSeqHandler(s)}function be(e,n,r,s){const 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r=Object.keys(n),s=r.length,o=0;return new $((function(){var i=null;do{if(o>=s)return e&&e.wrap(n),{done:!0};var a=n[r[o++]],c=a.source,l=a.target;i=c===t?l:c,e&&e.has(i.key)&&(i=null)}while(null===i);return{done:!1,value:{neighbor:i.key,attributes:i.attributes}}}))}function fe(e,t,n,r,s){for(var o,i,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(o=h.next()).done;){var m=!1;if(i=o.value,"undirected"!==p)for(a in c=i.out){l=c[a];do{if(u=l.target,m=!0,d=s(i.key,u.key,i.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=i.undirected)if(!(t&&i.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=s(i.key,u.key,i.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=s(i.key,null,i.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new V('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new V("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new V("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!l(e))throw new V('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new V("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new V("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new V("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new V("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ee={allowSelfLoops:!0,multi:!1,type:"mixed"};function Te(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Ce(e,t,n,r,s,o,i,a){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new V("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,i=""+i,a=a||{},!e.allowSelfLoops&&o===i)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(o),u=e._nodes.get(i);if(!c)throw new U("Graph.".concat(t,': source node "').concat(o,'" not found.'));if(!u)throw new U("Graph.".concat(t,': target node "').concat(i,'" not found.'));var d={key:null,undirected:r,source:o,target:i,attributes:a};if(n)s=e._edgeKeyGenerator();else if(s=""+s,e._edges.has(s))throw new Y("Graph.".concat(t,': the "').concat(s,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[i]:void 0!==c.out[i]))throw new Y("Graph.".concat(t,': an edge linking "').concat(o,'" to "').concat(i,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,s,c,u,a);e._edges.set(s,h);var p=o===i;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=s,e.emit("edgeAdded",d),s}function Se(e,t,n,r,s,o,i,c,u){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new V("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new V("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(o=""+o,i=""+i,u&&(d=c,c=void 0),!e.allowSelfLoops&&o===i)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(o),f=e._nodes.get(i);if(!n&&(h=e._edges.get(s))){if(!(h.source.key===o&&h.target.key===i||r&&h.source.key===i&&h.target.key===o))throw new Y("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(s,'" edge with "').concat(o,'" source & "').concat(i,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[i]:m.out[i]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var b={key:null,undirected:r,source:o,target:i,attributes:c};if(n)s=e._edgeKeyGenerator();else if(s=""+s,e._edges.has(s))throw new Y("Graph.".concat(t,': the "').concat(s,'" edge already exists in the graph.'));var w=!1,v=!1;m||(m=Te(e,o,{}),w=!0,o===i&&(f=m,v=!0)),f||(f=Te(e,i,{}),v=!0),h=new K(r,s,m,f,c),e._edges.set(s,h);var A=o===i;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,b.key=s,e.emit("edgeAdded",b),[s,!0,w,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,s=t.attributes,o=t.undirected,i=n===r;o?(n.undirectedDegree--,r.undirectedDegree--,i&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,i&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),o?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:s,source:n.key,target:r.key,undirected:o})}var Pe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ee,e)).multi)throw new V("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new V('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new V("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?B:"directed"===e.type?W:j;d(i(t),"NodeDataClass",r);var s="geid_"+we()+"_",o=0;return d(i(t),"_attributes",{}),d(i(t),"_nodes",new Map),d(i(t),"_edges",new Map),d(i(t),"_directedSize",0),d(i(t),"_undirectedSize",0),d(i(t),"_directedSelfLoopCount",0),d(i(t),"_undirectedSelfLoopCount",0),d(i(t),"_edgeKeyGenerator",(function(){var e;do{e=s+o++}while(t._edges.has(e));return e})),d(i(t),"_options",e),Ae.forEach((function(e){return d(i(t),e,t[e])})),h(i(t),"order",(function(){return t._nodes.size})),h(i(t),"size",(function(){return t._edges.size})),h(i(t),"directedSize",(function(){return t._directedSize})),h(i(t),"undirectedSize",(function(){return t._undirectedSize})),h(i(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(i(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(i(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(i(t),"multi",t._options.multi),h(i(t),"type",t._options.type),h(i(t),"allowSelfLoops",t._options.allowSelfLoops),h(i(t),"implementation",(function(){return"graphology"})),t}t(r,n);var s=r.prototype;return s._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},s.hasNode=function(e){return this._nodes.has(""+e)},s.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);return!!s&&s.out.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);return!!s&&s.undirected.hasOwnProperty(t)}throw new V("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new V("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},s.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},s.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new U('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},s.edge=function(e,t){if(this.multi)throw new Y("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new U('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},s.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},s.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},s.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},s.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},s.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},s.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},s.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new U('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},s.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},s.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},s.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},s.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},s.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},s.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},s.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},s.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},s.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},s.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},s.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},s.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},s.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},s.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new U('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},s.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},s.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},s.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},s.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new U('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,s=n.target.key;if(e===r)return s;if(e===s)return r;throw new U('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(s,")."))},s.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new U('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},s.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},s.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},s.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new U('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},s.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new V('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new Y('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},s.mergeNode=function(e,t){if(t&&!l(t))throw new V('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},s.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new V('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var s=t?t({}):{};return n=new this.NodeDataClass(e,s),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:s}),[e,!0]},s.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new U('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var s in n.in){t=n.in[s];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},s.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new U('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new U('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},s.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new U('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},s.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new U('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},s.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},s.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},s.getAttribute=function(e){return this._attributes[e]},s.getAttributes=function(){return this._attributes},s.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},s.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},s.updateAttribute=function(e,t){if("function"!=typeof t)throw new V("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},s.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},s.replaceAttributes=function(e){if(!l(e))throw new V("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},s.mergeAttributes=function(e){if(!l(e))throw new V("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},s.updateAttributes=function(e){if("function"!=typeof e)throw new V("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},s.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,s=this._nodes.values();!0!==(n=s.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},s.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new V("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new V("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,s,o,i=this._edges.values();!0!==(n=i.next()).done;)s=(r=n.value).source,o=r.target,r.attributes=e(r.key,r.attributes,s.key,o.key,s.attributes,o.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},s.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},s.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},s.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},s.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new V("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},s.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},s.forEachNode=function(e){if("function"!=typeof e)throw new V("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},s.findNode=function(e){if("function"!=typeof e)throw new V("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},s.mapNodes=function(e){if("function"!=typeof e)throw new V("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),s=new Array(this.order),o=0;!0!==(t=r.next()).done;)n=t.value,s[o++]=e(n.key,n.attributes);return s},s.someNode=function(e){if("function"!=typeof e)throw new V("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},s.everyNode=function(e){if("function"!=typeof e)throw new V("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},s.filterNodes=function(e){if("function"!=typeof e)throw new V("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),s=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&s.push(n.key);return s},s.reduceNodes=function(e,t){if("function"!=typeof e)throw new V("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new V("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,s=t,o=this._nodes.values();!0!==(n=o.next()).done;)s=e(s,(r=n.value).key,r.attributes);return s},s.nodeEntries=function(){var e=this._nodes.values();return new $((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},s.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,s){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,s,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},s.import=function(e){var t,n,s,o,i,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,s,o,i){c?i?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):i?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new V("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new V("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(s=e.nodes,!Array.isArray(s))throw new V("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=s.length;t<n;t++){ge(o=s[t]);var u=o,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),s=e.edges,!Array.isArray(s))throw new V("Graph.import: invalid edges. 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class{constructor(){this.regionTypes=[Y.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=q.fH.Entropy,this.filterSource=q.Fo.filterSource}},n(7602),n(8047),function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(B||(B={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(W||(W={})),a.JsViewer,n(6863),n(2780),n(8115),a.JsViewer,n(1407),H.b9[H.Hi.FASTA],n(5433),n(3890),n(1687),function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(j||(j={}));class z{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const r=this.isWhitespace(n)?t:t-1;for(let e=0;e<r;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToAtomType(n),t[r]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let r=this.getAtomBlockIdx();for(let s=0;s<this.atomCount;s++){r=this.shiftIdxToXColumn(r);for(const o of[e,t,n])o[s]=this.parseFloatValue(r),r=this.getNextColumnIdx(r);r=this.getNextLineIdx(r)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const r=new Uint16Array(2);r[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),r[1]=this.parseIntValue(t),e[n]=r,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToBondType(n),t[r]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Z extends z{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let r=0;r<t;r++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class X extends Z{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(j.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,r]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,r)}}));const n=t.map(((e,t)=>{if(e.startsWith(j.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),r=n.map((e=>t[e])),s=n.map((e=>t[e+1]));r.forEach(((t,n)=>{const r=parseInt(t.split(/\s+/)[1])-1,o=parseInt(s[n].substring(1));if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,r)}));const o=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(j.TYPE)&&-1!==e.indexOf(j.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,j.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<j.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,j.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,j.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+j.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=j.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Q extends Z{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const s=t[1];if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class J{constructor(){}static getInstance(e){if(J.isMolfileV2K(e))return new X(e);if(J.isMolfileV3K(e))return new Q(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return X.isValidMolfile(e)}static isMolfileV3K(e){return Q.isValidMolfile(e)}}var ee=n(6197),te=n(9124),ne=n(3527),re=n(3629);class se{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",r=void 0,s=void 0,o=void 0,i){if(this.biotype=e,this.id=t,this.n=n,this.m=r,this.type=s,this.mt=o,this.smiles=i,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++se.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class oe extends se{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class ie extends se{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class ae extends se{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class ce extends se{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class le{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,r,s,o,i,a){this.id=e,this.m=t,this.n=n,this.na=r,this.type=s,this.mt=o,this.at=i,this.smiles=a}static fromMonomer(e,t,n){let r={};const s=t.symbol,o=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{r[e.label]=e.capGroupName}));else{if(!o){if(t.lib)return new ce(e,s);throw new Error("Unexpected missing monomer without .lib")}r=n.getRS(o)}const i=new le(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,r),a=n.getMonomerColors(e,t.symbol);return a&&(i.textcolor=a?.textcolor,i.linecolor=a?.linecolor,i.backgroundcolor=a?.backgroundcolor),i}}const ue={[U.o.BASE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.NUCLEOTIDE]:{A:"#20E040",G:"#040404",T:"#FF8080",C:"#2060FF",U:"#FF8080"},[U.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[U.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[U.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[U.o.CHEM]:{R:"#eeeeee"},[U.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},de=/[\w()]+/,he=RegExp(String.raw`\(${de}(,${de})+\)`),pe=new ne.Mi([255,255,255]),me=new ne.Mi([0,0,0]),fe=.7*(0,re.wQ)(pe);class ge{_monomers;source;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new c.Subject;get onChanged(){return this._onChanged}constructor(e,t){this._monomers=e,this.source=t,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length))}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t==H._S||t===H.b9[H.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:L().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ye.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}getWebEditorMonomer(e,t){const[n,r]=(0,te.fA)(e,t),s=(0,ee.Y)(n);let o=this.getMonomer(s,r);if(o&&n==U.o.LINKER&&2!=o.rgroups.length)return null;if(o&&n==U.o.SUGAR&&3!=o.rgroups.length)return null;o||(o=this.addMissingMonomer(s,r));let i=o.wem??null;return i||(r===H._S||"*"==r?i=o.wem=new oe(n):n===U.o.NUCLEOTIDE&&"N"===r||n===U.o.AA&&"X"===r||(U.o.CHEM,0)||he.test(r)?i=o.wem=new ie(n,r):o.lib||(i=o.wem=new ae(n,r,this.isEmpty)),i||(i=o.wem=le.fromMonomer(n,o,this))),i}getTooltip(e,t){const n=(0,ee.Y)(e),r=i.div([],{classes:"ui-form ui-tooltip"}),s=this.getMonomer(n,t);if(s){const n=s.symbol,a=(s.name,this.getWebEditorMonomer(e,t));a.backgroundcolor,r.append(i.divH([i.div([n],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:a.textcolor,backgroundColor:a.backgroundcolor,borderColor:a.linecolor,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),i.div([s.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const c={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let l;l=s.molfile?o.chem.svgMol(s.molfile,void 0,void 0,c):s.smiles?i.divV([o.chem.svgMol(s.smiles,void 0,void 0,c),i.divText("from smiles",{style:{fontSize:"smaller"}})]):i.divText("No structure",{style:{margin:"6px"}}),r.append(i.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),s.symbol!=H._S&&r.append(i.divText(s.lib?.source??"Missed in libraries"))}else r.append(i.divV([i.divText(`Monomer '${t}' of type '${n}' not found.`),i.divText("Open the Context Panel, then expand Manage Libraries")]));return r}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),r=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const n=a.Color.fromHtml(e);return[a.Color.r(n),a.Color.g(n),a.Color.b(n)]},s=r(n.textcolor),o=new ne.Mi([...s.map((e=>e+1))]),i=(0,re.KE)(o,pe)/((0,re.wQ)(o)*(0,re.wQ)(pe)),c=r(n.backgroundcolor),l=new ne.Mi([...c.map((e=>e+.01))]);let u;u=(0,re.KE)(l,pe)/((0,re.wQ)(l)*(0,re.wQ)(pe))<i?c:s;let d=new ne.Mi(u);const h=(0,re.wQ)(d);return h>fe&&(d=(0,re.dC)(me,d,fe/h)),`rgb(${d[0]}, ${d[1]}, ${d[2]})`}getMonomerColors(e,t){const n="default";let r=n;const s=(0,ee.Y)(e),o=this.getMonomer(s,t);let i;if(o){if(o.meta&&o.meta.colors){const e=o.meta.colors;n in e||(r="default"),i=e[r]}if(!i){const t=ue[e],n=t?.[o.symbol];n&&(i={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=o.naturalAnalog;if(!i&&t)return this.getMonomerColors(e,t)}return i||(i={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:i.text??i.textColor,linecolor:i.line??i.lineColor,backgroundcolor:i.background??i.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let r,s="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){r=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(s+=t[e][n]);n["R"+r]=s,s=""}return n}}var ye=n(5488),be={};be.styleTagTransform=v(),be.setAttributes=g(),be.insert=m().bind(null,"head"),be.domAPI=h(),be.insertStyleElement=b(),u()(ye.A,be),ye.A&&ye.A.locals&&ye.A.locals;class we extends ge{error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t,n=void 0){super(e,t),this.error=n;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?.[n]??null}else{Ye.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=(0,ee.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=J.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,F.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const s=e.duplicateMonomerPreferences[n][r],o=this.duplicateMonomers[n][r].find((e=>e.lib?.source===s));o?this._monomers[n][r]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of L().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}override(e,t){return new ve(e,t,this)}}class ve extends ge{data;base;constructor(e,t,n){super(e,t),this.data=e,this.base=n}get onChanged(){return this.base.onChanged}getMonomerSymbolsByType(e){const t=this.base.getMonomerSymbolsByType(e);for(const n of Object.keys(this.data[e]??{}))t.includes(n)||t.push(n);return t}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}var Ae=n(9192);class Ee{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,s){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=s;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,Ae.AP)(e);this.error=t,this.monomers=[]}}}class Te{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var Ce=n(7433),Se=n.n(Ce),_e=n(1913),Pe=n.n(_e);class Ne{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Se())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Pe()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const s of e){const e=s.symbol??s.id??s.name??"#N/A";if(n=this.validateMonomerSchema(s),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,s,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${s.polymerType??""}-${e}`;r.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(o)}return n}}var Me=n(8604);class xe{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++xe.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await o.dapi.files.readAsText(Me.gt),s=JSON.parse(r),i=new Ne(s);return new xe(i,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists(Me.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText(Me.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists(Me.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete(Me.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists(Me.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),s=await r.readAsText(t);n=JSON.parse(s);const o={},i=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;i.includes(t)||(o[t]={},i.push(t)),o[t][n]=e})),new we(o,t)}async loadSetFromFile(e,t,n){let r={};const s=new a.FileSource(t),o=await s.readAsText(n);r=JSON.parse(o);const i=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,s=n.polymerType,o=n.monomerType,i=n.set;return new Ee(e,r,s,o,i)}));return new Te(i,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText(Me.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${Me.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ye.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ye.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ye.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText(Me.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ye.logger.debug(`${e}, OUT`)})),Ye.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(Me.so).then((e=>e.filter((e=>e.isFile)).map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Me.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list(Me.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(Me.Es.length)))}}class $e{constructor(){}static _instance;static getInstance(){return $e._instance||($e._instance=new $e),$e._instance}_libFilesUpdateSubject$=new c.BehaviorSubject([]);_setFilesUpdateSubject$=new c.BehaviorSubject([]);_addLibraryFilesSubject$=new c.Subject;_librarySelectionSubject$=new c.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,T.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Le{logger;_monomerLib=new we({},"MAIN");_monomerSets=new Te("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=1/0){return e=e===1/0?6e4:e,await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,K.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Le.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Le.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await xe.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,F.ub)()]),s=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let o=0;const i=s.length,[a]=await Promise.all([Promise.all(s.map((e=>this.readLibrary(Me.so,e).catch((t=>{const n=`Loading monomers from '${e}' 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s=n.length,[o]=await Promise.all([Promise.all(n.map((t=>this.readSet(Me.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new Te("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/s),`Loading monomers ${r}/${s}`)})))))]);this._monomerSets.updateSets(o)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the 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Error(`Error: ${e}`)}if(!o){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await r.dapi.docker.dockerContainers.request(e,l,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const s=u["datagrok-error"];if(s)throw new Error(`Datagrok error: ${s}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];i?.warning(e)}return u}},3890:(e,t,n)=>{"use strict";n.d(t,{aS:()=>a,wz:()=>i}),n(6082),n(7389),n(4328);var r=n(1991),s=n.n(r);n(4374);const o=60;function i(e,t,n=o,r="\n"){const s=[];for(let o=0;o<t.length;o++){const i=e.map((e=>e.get(o).toString())).join("|"),c=a(t.getSplitted(o),n);s.push(`>${i}${r}`);for(const e of c)s.push(`${e}${r}`)}return"".concat(...s)}function a(e,t=o){let n=0;const r=e.length,i=[];for(;n<r;){const r=s().count(n).take(Math.min(e.length-n,t)).map((t=>e.getOriginal(t))).toArray(),o=r.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");i.push(o),n+=r.length}return i}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var r=n(4328),s=n(6077),o=n(2003),i=n(8312),a=n(310),c=n(966),l=n(330);async function u(e,t,n,u,d,h,p){let m;if(n){const n=await(0,i.Q)(),r=n.getSeqHandler(t);let s,a;r.isHelm()?s=t:(a=t.name,t.name=`__${a}`,s=r.convert(o.Hi.HELM),s.name=a,e.columns.add(s,!1));try{m=await n.helmToAtomicLevel(s,!0,!0)}finally{s!==t&&(e.columns.remove(s.name),t.name=a)}}else{if(!(0,c.l)(t,"To Atomic Level",h)[0])return{molCol:null,warnings:["Column is not suitable"]};m=await(0,s.C4)(e,t,d,h,p)}if(m.molCol){const n=(0,l.qj)(e,t.name);m.molCol.name=n,e.columns.add(m.molCol,!0),(0,a.Qc)(t,m.molCol,d,h,p),m.molCol.setTag(".sequence-src-highlight-monomers",String(u)),await r.data.detectSemanticTypes(e)}return m}},4870:(e,t,n)=>{"use strict";function r(e,t){e.innerHTML="",e.append(t)}n.d(t,{K:()=>r}),n(4328),n(6082)},8047:(e,t,n)=>{"use strict";n.d(t,{VN:()=>m,n5:()=>l,Ue:()=>p,Tc:()=>h,eN:()=>f}),n(4328),n(7389);var r=n(6082),s=(n(1757),n(1991),n(1858),n(2003)),o=n(4326);n(8070),n(7602);var i=n(439),a=n(6882);var c,l,u,d=n(2174);n(4374),HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class h{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class p{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,r){this.pos=e,this.name=t,this._freqs=n??{},r?.sumRowCount&&(this.sumRowCount=r.sumRowCount),r?.sumValueForHeight&&(this.sumPlotValue=r.sumValueForHeight),r?.label&&(this._label=r.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new h),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===o.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const r=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-r*Math.log2(r)}}else if(e===o.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,s,a,c,l,u,d){const h=s===o.fH.Entropy?n*(a-this.sumPlotValueForHeight)/a:n;let p=d*u+(n-h-1);const m=Object.entries(this._freqs).sort(((e,t)=>e[0]!==i._S&&t[0]!==i._S?t[1].value-e[1].value:e[0]===i._S&&t[0]===i._S?0:e[0]===i._S?-1:1));for(const[n,s]of m){const n=h*s.plotValue/this.sumPlotValue;s.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,o,c){for(const[l,u]of Object.entries(this._freqs))if(l!==i._S){const i=(0,s.zS)(l,5),d=u.bounds,h=d.left;let p=a.S$;c&&(p=c.getMonomerTextColor(o,l)),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(h,d.top,d.width,d.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(i);e.setTransform(d.width/m.width,0,0,d.height/r,h,d.top),e.fillText(i,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,d.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(c||(c={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(l||(l={})),o.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(u||(u={}));const m=new class{render=20};function f(e,t,n,r,s){let o=0,i=-1;for(;-1!=(i=n.findNext(i,!0));){const e=t.getSplitted(i),n=s.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&o++}return o}r.JsViewer},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>i,n:()=>o});var r=n(1858),s=n(4374);class o{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(s._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class i{onChanged=new r.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>C,AR:()=>T});var r=n(7389),s=n(6082),o=n(4328),i=n(1991),a=n.n(i),c=n(1858),l=n(2003),u=n(8070),d=n(7602),h=n(8115),p=n(4577),m=n(1757),f=n.n(m),g=n(9124),y=n(9192),b=n(4870),w=n(4374);class v extends p.O{seqHelper;emptyProps=new p.n("");helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++v.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(e){super(),this.seqHelper=e,this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,g.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.n(e)}catch(e){this.logger.error(e)}finally{f()(t).empty(),t=null,n=null}})).onCancel((()=>{f()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.AP)(e),s=this._filterPanel;s.innerText="error",s.classList.add("d4-error"),r.tooltip.bind(s,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,b.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,h.if)(this.props.substructure,e,this.seqHelper)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class E{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,s){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=s}}class T extends p.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class C extends s.Filter{seqHelper;logger;bioFilter=null;bitset=null;loader;notation=void 0;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(e,t){super(),this.seqHelper=e,this.logger=t,this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new d.g(this.logger)}static filterCounter=-1;filterId=++C.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(s.SEMTYPE.MACROMOLECULE)),this.seqHelper.getSeqHandler(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new S:this.notation===l.Hi.SEPARATOR?new _(this.column.getTag(l.gp.separator)):new v(this.seqHelper),this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(s.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=s.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;this.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(A,new E(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(this.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{this.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,this.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;this.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class S extends p.O{emptyProps=new p.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new p.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,h.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class _ extends p.O{emptyProps=new T("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new T(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("")}get filterPanel(){return 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n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await e.loadMonomerLibForTests(),function(e,n){const r=n,s=e.getSummaryObj();for(const e in r)r[e]||delete r[e];for(const e in s)s[e]||delete s[e];if(0==Object.keys(r).length&&0!=Object.keys(s).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(r).length&&0==Object.keys(s).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(s,r),(0,t.Xk)(r,s)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(r)} does not match actual ${JSON.stringify(s)}.`)}}(e.getMonomerLib(),$.VV)})),(0,t.t6)("empty",(async()=>{const n=await(0,N.ub)(),r=await e.getFileManager();let s=r.getValidLibraryPaths();0===s.length&&(s=await r.getValidLibraryPathsAsynchronously()),n.exclude=s,n.explicit=[],await(0,N.Eu)(n),await e.loadMonomerLib(!0);const o=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===o.length,!0)})),(0,t.t6)("override",(async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test Author",id:0,rgroups:[],smiles:"",polymerType:"PEPTIDE",monomerType:"Backbone",createDate:null},r=e.getMonomerLib(),s=r.getMonomer(n.polymerType,n.symbol);(0,t.E3)(null===s,!0,`Unexpectedly found monomer '${n.symbol}' `);const o=r.override({[n.polymerType]:{[n.symbol]:n}},"test").getMonomer(n.polymerType,n.symbol);(0,t.Xk)(o,n)}))}));var L=n(7389),I=n(1757),R=n.n(I),O=n(1858),k=n(6873),G=n(5433);async function D(n,r){const s=n(),o=e.DataFrame.fromColumns(s);await a.data.detectSemanticTypes(o);const i=Date.now(),c=(o.columns.byName("MSA"),a.shell.addTableView(o));await _(c.grid),(0,t.E3)(c.grid.dataFrame.id,o.id);const l=Date.now()-i;console.log(`Performance test: ${r}: ${l}ms`)}(0,t.L1)("renderers",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),(0,t.t6)("long sequence performance ",(async()=>{await D(k.dW,"Long sequences")})),(0,t.t6)("many sequence performance",(async()=>{await D(k.fD,"Many sequences")})),(0,t.t6)("rendererMacromoleculeFasta",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),s=r.getCol("Sequence"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=s.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),s=r.getCol("sequence"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const c=s.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),s=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await _(s.grid),(0,t.E3)(s.grid.dataFrame.id,r.id);const o=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(o,P.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),s=(await a.functions.call("Bio:importFasta",{fileContent:r}))[0],o=s.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:o});i&&(o.semType=i);const l=a.shell.addTableView(s);await a.data.detectSemanticTypes(s),console.log("Bio: tests/renderers/afterMsa, table view"),await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${o.semType}", units="${o.meta.units}", cell.renderer="${o.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(o.meta.units,c.Hi.FASTA),(0,t.E3)(o.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(o.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(o.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,y.D)({col:o},n);await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const r=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),s=e.DataFrame.fromCsv(r),o=s.getCol("sequence"),i=await a.functions.call("Bio:detectMacromolecule",{col:o});i&&(o.semType=i);const l=a.shell.addTableView(s);await a.data.detectSemanticTypes(s);const u=await(0,G.r)(o,n,c.Hi.SEPARATOR,"/");await _(l.grid),(0,t.E3)(l.grid.dataFrame.id,s.id);const d=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),n.getSeqHandler(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const r=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),s=a.shell.addTableView(r);await _(s.grid);const o=r.getCol("sequence"),i=n.getSeqHandler(o).convert(c.Hi.HELM);r.columns.add(i),await _(s.grid),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const s=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==s)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${s}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const n=e.DataFrame.fromCsv(r);n.currentRowIdx=0;const s=a.shell.addTableView(n),o=n.plot.scatter({x:"x",y:"y"});s.dockManager.dock(o,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(o.onAfterDrawScene,(()=>{}),(()=>{o.invalidateCanvas()}),1e3),_(s.grid,500)]);const i=o.root.getBoundingClientRect(),c=o.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:i.left+c.x,clientY:i.top+c.y}),u=R()(o.root).find("canvas").get()[0];await(0,t.PE)((0,O.fromEvent)(u,"mousemove"),(()=>{Se.logger.debug(`Test: event, currentRowIdx=${n.currentRowIdx}`),(0,t.E3)(R()(L.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(o.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await _(s.grid,500)}()}));const r="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var H=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,T.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const s={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(s))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),s=new H.Jy(null,n,Se.logger,3,(()=>({monomerCharWidth:7,separatorWidth:12,monomerToShort:c.zS})));await s.init();const o=r.testList;for(let e=0;e<n.length;++e)s.getCellMonomerLengths(e,1e4);const i=[];for(const[e,t]of A().enumerate(o)){const t={pos:s.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&i.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(i.length>0)throw new Error("Test failed error(s):\n"+i.join(", \n"))}));const o=[10,20,30,40,50,60],i={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[e,n]of Object.entries(i))(0,t.t6)("hitBounds-"+e,(async()=>{const e=(0,H.Bb)(o,n.x);(0,t.E3)(e,n.tgt)}))})),(0,t.L1)("converters",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,l.Q)()})),function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(r||(r={}));const s={[r.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[r.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[r.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[r.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[r.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[r.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[r.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[r.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[r.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[r.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[r.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[r.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[r.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[r.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[r.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[r.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[r.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[r.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},o=new Set(Object.values(c.gp));async function i(t){const n=s[t],r=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(r),r}function u(e,r){if(e===c.Hi.SEPARATOR&&!r)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(s){const o=n.getSeqHandler(s).convert(e,r);return(0,t.E3)(o.meta.units,e),o}}async function d(e,r,s){const a=(await i(e)).getCol("seq"),l=r(a),u=(await i(s)).getCol("seq");(0,t.J6)(l.toList(),u.toList());const d=n.getSeqHandler(a),h=n.getSeqHandler(l);for(const[e,n]of Object.entries(u.tags)){if(!o.has(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const r=l.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await 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n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function s(e){const s=new F.m(e),o=s.descriptionsArray,i=s.sequencesArray;(0,t.J6)([o,i],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{s(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{s(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n 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i.awaitRendered()})),(0,t.t6)("positions with shrinkEmptyTail option true (filtered)",(async()=>{const n=e.DataFrame.fromCsv("seq\n-TC-G-TTGC--\n-TC-GCTTGC--\n-T--C-GT-\n-T--C-GT-\n-T--C-GT-\n-T--CCGT-"),r=a.shell.addTableView(n),s=n.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.DNA),s.setTag(c.gp.aligned,"SEQ"),n.filter.init((e=>e>2)),n.filter.fireChanged();const o=await n.plot.fromType("WebLogo",{shrinkEmptyTail:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const i=o.positions,l=[new W.Ue(0,"1",{[j]:new W.Tc(3)}),new W.Ue(1,"2",{T:new W.Tc(3)}),new W.Ue(2,"3",{[j]:new W.Tc(3)}),new W.Ue(3,"4",{[j]:new W.Tc(3)}),new W.Ue(4,"5",{C:new W.Tc(3)}),new W.Ue(5,"6",{[j]:new W.Tc(2),C:new W.Tc(1)}),new W.Ue(6,"7",{G:new W.Tc(3)}),new W.Ue(7,"8",{T:new W.Tc(3)}),new W.Ue(8,"9",{[j]:new W.Tc(3)})];(0,t.E3)(i.length,l.length);for(let e=0;e<i.length;e++){(0,t.E3)(i[e].name,l[e].name);for(const n of i[e].getMonomers())(0,t.E3)(i[e].getFreq(n).rowCount,l[e].getFreq(n).rowCount)}await o.awaitRendered()})),(0,t.t6)("positions with skipEmptyPositions option",(async()=>{const n=e.DataFrame.fromCsv(r),s=a.shell.addTableView(n),o=n.getCol("seq");o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=c.Hi.FASTA,o.setTag(c.gp.alphabet,c.YI.DNA),o.setTag(c.gp.aligned,"SEQ.MSA");const i=await n.plot.fromType("WebLogo",{skipEmptyPositions:!0});await(0,t.PE)(i.onLayoutCalculated,(()=>{}),(()=>{s.dockManager.dock(i.root,e.DOCK_TYPE.DOWN)}),500);const l=i.positions,u=[new W.Ue(0,"1",{A:new W.Tc(2),[j]:new W.Tc(3)}),new W.Ue(1,"2",{T:new W.Tc(5)}),new W.Ue(2,"3",{C:new W.Tc(5)}),new W.Ue(4,"5",{G:new W.Tc(5)}),new W.Ue(5,"6",{[j]:new W.Tc(3),C:new W.Tc(2)}),new W.Ue(6,"7",{T:new W.Tc(5)}),new W.Ue(7,"8",{T:new W.Tc(5)}),new W.Ue(8,"9",{G:new W.Tc(5)}),new W.Ue(9,"10",{C:new W.Tc(5)})];(0,t.E3)(l.length,u.length);for(let e=0;e<l.length;e++)K(l[e],u[e]);await i.awaitRendered()})),(0,t.t6)("count sequences for monomer at position",(async()=>{const s=function(t,n,r){const s=e.DataFrame.fromCsv(t),o=s.getCol("seq");return o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=n,o.setTag(c.gp.alphabet,r),o.setTag(c.gp.aligned,"SEQ.MSA"),s}(r,c.Hi.FASTA,c.YI.DNA),o=s.getCol("seq"),i=a.shell.addTableView(s),l=await s.plot.fromType("WebLogo",{startPositionName:"3",endPositionName:"7",skipEmptyPositions:!0});await(0,t.PE)(l.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(l.root,e.DOCK_TYPE.DOWN)}),500);const u=l.positions,d=[new W.Ue(2,"3",{C:new W.Tc(5)}),new W.Ue(4,"5",{G:new W.Tc(5)}),new W.Ue(5,"6",{[j]:new W.Tc(3),C:new W.Tc(2)}),new W.Ue(6,"7",{T:new W.Tc(5)})];(0,t.E3)(u.length,d.length);for(let e=0;e<u.length;e++)K(u[e],d[e]);const h=u[1],p=n.getSeqHandler(o),m=(0,W.eN)(s,p,s.filter,"G",h);(0,t.E3)(m,5),await l.awaitRendered()})),(0,t.t6)("empty",(async()=>{const n=e.DataFrame.fromColumns([(()=>{const 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a.dapi.projects.save(o)}(n,r.getTableInfo(),i,r),a.shell.closeAll(),await(0,t.cb)(500),await a.dapi.projects.open(n);const l=a.shell.getTableView(s),u=A()(l.viewers).toArray();(0,t.E3)(u.length,2),(0,t.E3)(u.filter((e=>"Grid"===e.type)).length,1);const d=u.find((e=>"WebLogo"===e.type));(0,t.E3)(!!d,!0),await _(i.grid),await d.awaitRendered()}),{skipReason:"depends on 1.18"})})),(0,t.L1)("WebLogo.layout",(()=>{(0,t.t6)("fasta",(async()=>{const e=await Se.files.readCsv("tests/filter_FASTA.csv"),n=e.getCol("fasta");await a.data.detectSemanticTypes(e);const r=a.shell.addTableView(e),s=await e.plot.fromType("WebLogo",{sequenceColumnName:n.name});r.dockManager.dock(s),await(0,t.cb)(2*W.VN.render),await s.awaitRendered(),await _(r.grid);const o=r.saveLayout();o.toJson(),r.loadLayout(o),await(0,t.cb)(2*W.VN.render),await s.awaitRendered(),await _(r.grid);const i=A()(r.viewers).toArray();(0,t.E3)(i.length,2),(0,t.E3)(i.filter((e=>"Grid"===e.type)).length,1),(0,t.E3)(i.filter((e=>"WebLogo"===e.type)).length,1)}))}));var q=n(966);function z(e,t){let n=null;for(const r of e.viewers)r.type===t&&(n=r);return n}(0,t.L1)("checkInputColumn",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r="seq\nseq1,\nseq2,\nseq3,\nseq4";(0,t.t6)("testMsaPos",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.DNA),s.setTag(c.gp.aligned,"SEQ");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!0)})),(0,t.t6)("testMsaNegHelm",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.HELM,s.setTag(c.gp.alphabetIsMultichar,"true");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!1)})),(0,t.t6)("testMsaNegUN",(async()=>{const s=e.DataFrame.fromCsv(r).getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,"UN"),s.setTag(c.gp.alphabetSize,"11"),s.setTag(c.gp.alphabetIsMultichar,"true"),s.setTag(c.gp.aligned,"SEQ");const[o,i]=(0,q.l)(s,"Test",n,[c.Hi.FASTA],[c.YI.DNA,c.YI.RNA,c.YI.PT]);(0,t.E3)(o,!1)})),(0,t.t6)("testGetActionFunctionMeta",(async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find((e=>"sequence"==e.name))}))})),(0,t.L1)("similarity/diversity",(async()=>{(0,t.t6)("similaritySearchViewer",(async()=>{await async function(){const n=await Se.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(r);const s=a.shell.addTableView(r),o=s.dataFrame.getCol("MSA");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const i=await s.dataFrame.plot.fromType("Sequence Similarity Search");let c=!1;if(i.computeCompleted.subscribe((e=>{e&&(c=!0)})),s.dockManager.dock(i,e.DOCK_TYPE.RIGHT,null,"Similarity"),await i.renderPromise,await(0,t.bk)((()=>void 0!==z(s,"Sequence Similarity Search")),"Sequence Similarity Search viewer has not been created",100),!i.initialized)throw new Error("The viewer is not initialized.");if(!i.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!i.beforeRender())throw new Error("The viewer is not able to render.");if(!i.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=i;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Similarity Search viewer grid has not been created",100);(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.scores.get(0),e.FLOAT_NULL),(0,t.E3)(l.idxs.get(0),0),(0,t.E3)(l.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(l.scores.get(1).toFixed(2),"0.73"),(0,t.E3)(l.idxs.get(1),4),(0,t.E3)(l.molCol.get(1),"Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"),s.dataFrame.currentRowIdx=1,await(0,t.bk)((()=>1===l.targetMoleculeIdx),"Target molecule has not been changed",5e3),await(0,t.bk)((()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===l.molCol.get(0)),"Incorrect first similar molecule",5e3)}()})),(0,t.t6)("diversitySearchViewer",(async()=>{await async function(){const n=await Se.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n),s=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const o=s.dataFrame.getCol("MSA");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const i=await s.dataFrame.plot.fromType("Sequence Diversity Search");let c=!1;if(i.computeCompleted.subscribe((e=>{e&&(c=!0)})),s.dockManager.dock(i,e.DOCK_TYPE.DOWN,null,"Diversity"),await i.renderPromise,await(0,t.bk)((()=>void 0!==z(s,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!i.initialized)throw new Error("The viewer is not initialized.");if(!i.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!i.beforeRender())throw new Error("The viewer is not able to render.");if(!i.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=i;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.initialized,!0),(0,t.E3)(l.renderMolIds.length>0,!0)}()}))}));var Z=n(1687),X=n(4577);(0,t.L1)("bio-substructure-filters",(async()=>{let n,r,s;async function o(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const r=new Z._i(n,Se.logger);return r.attach(t),r.applyState({columnName:e}),r.column=t.col(e),r.columnName=e,r}(0,t.gM)((async()=>{n=await(0,l.Q)(),r=await(0,T.pj)(),s=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await r.loadMonomerLib(!0)})),(0,t.t6)("fasta",(async()=>{const e=await S("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const r=new Z._i(n,Se.logger);r.attach(e),await r.awaitRendered();try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const n=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("MD")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,3),(0,t.E3)(r.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{r.detach()}await r.awaitRendered()})),(0,t.t6)("separator",(async()=>{const e=await S("tests/filter_MSA.csv"),r=new Z._i(n,Se.logger);await a.data.detectSemanticTypes(e),r.attach(e),await r.awaitRendered();try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter");const n=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,7),(0,t.E3)(r.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("/meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{n.props=new Z.AR("meI-hHis","-")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(r.dataFrame.filter.trueCount,7),(0,t.E3)(r.dataFrame.filter.get(2),!1)}finally{r.detach()}await r.awaitRendered()})),(0,t.t6)("helm-dialog",(async()=>{const e="Bio tests: substructureFilters/helm-dialog",r=await S("tests/filter_HELM.csv");await a.data.detectSemanticTypes(r);const s=a.shell.addTableView(r);Se.logger.debug(`${e}, filter attaching.`);const o=new Z._i(n,Se.logger);o.attach(r);const i=L.dialog("Test filters").add(o.root).show();await o.awaitRendered();try{const n=o.bioFilter;(0,t.E3)(null!==o.bioFilter,!0,"bioFilter is not created"),Se.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(r.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("PEPTIDE1{A.C}$$$$V2.0")}),2e4),Se.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(o.dataFrame.filter.trueCount,1),(0,t.E3)(o.dataFrame.filter.toBinaryString(),"0001"),Se.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(r.onRowsFiltered,(()=>{}),(()=>{n.props=new X.n("PEPTIDE1{C}$$$$V2.0")}),2e4),await _(s.grid),Se.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(o.dataFrame.filter.trueCount,2),(0,t.E3)(o.dataFrame.filter.toBinaryString(),"1001")}finally{i.close()}await o.awaitRendered(),await(0,t.cb)(3e3)})),(0,t.t6)("helm-view",(async()=>{const e=await S("tests/filter_HELM.csv");e.getCol("HELM string"),await a.data.detectSemanticTypes(e);const t=a.shell.addTableView(e);t.getFiltersGroup(),await _(t.grid)})),(0,t.t6)("sync-fasta",(async()=>{const e=await Se.files.readCsv("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=await o("fasta",e),r=await o("fasta",e);await Promise.all([n.awaitRendered(),r.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const s=n.bioFilter,o=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{s.props=new X.n("MD")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(o.props.substructure,"MD")}finally{n.detach(),r.detach()}await Promise.all([n.awaitRendered(),r.awaitRendered()])})),(0,t.t6)("sync-msa",(async()=>{const e=await Se.files.readCsv("tests/filter_MSA.csv");await a.data.detectSemanticTypes(e);const n="hHis-Aca",r=await o("MSA",e),s=await o("MSA",e);await Promise.all([r.awaitRendered(),s.awaitRendered()]);try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(s.bioFilter.type,"SeparatorBioFilter");const o=r.bioFilter,i=s.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new Z.AR(n,"-")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(i.props.substructure,n),(0,t.E3)(i.props.separator,"-")}finally{r.detach(),s.detach()}await Promise.all([r.awaitRendered(),s.awaitRendered()])})),(0,t.t6)("sync-helm",(async()=>{const e=await Se.files.readCsv("tests/filter_HELM.csv");await a.data.detectSemanticTypes(e);const n=a.shell.addTableView(e),r="PEPTIDE1{A.C}$$$$V2.0",s=await o("HELM string",e),i=await o("HELM string",e),c=L.dialog("Test filters").add(s.root).add(i.root).show();await Promise.all([s.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(s.bioFilter.type,"HelmBioFilter"),(0,t.E3)(i.bioFilter.type,"HelmBioFilter");const o=s.bioFilter,a=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new X.n(r)}),6e4,"await onRowsFiltered"),await _(n.grid),Se.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*s.debounceTime),Se.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,1),await s.awaitRendered(),(0,t.E3)(a.props.substructure,r)}finally{s.detach(),i.detach(),c.close()}await Promise.all([s.awaitRendered(),i.awaitRendered()]),await _(n.grid),await(0,t.cb)(3e3)})),(0,t.t6)("two-columns-fasta",(async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),s="seq1",o="CGGCTG",i=n.getCol("trueSeq1").toList(),c="seq2",l="GCATT",u=n.getCol("trueSeq2").toList(),d=[{type:"Bio:bioSubstructureFilter",columnName:s},{type:"Bio:bioSubstructureFilter",columnName:c}],h=await n.plot.fromType(e.VIEWER.FILTERS,{filters:d});r.dockManager.dock(h,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid);const p=h.filters[0],m=h.filters[1];(0,t.E3)(p.column.name,s),(0,t.E3)(m.column.name,c);const f=p.bioFilter,g=m.bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n(o)}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n("")}),1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,i.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),i.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n(l)}),1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),u.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n("")}),1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new X.n(o)}),5e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new X.n(l)}),5e3,"testEvent onRowsFiltered on both");const y=A().count(0).take(n.rowCount).map((e=>i[e]*u[e])).toArray();(0,t.E3)(n.filter.trueCount,y.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),y.map((e=>e.toString())).join("")),await Promise.all([p.awaitRendered(),m.awaitRendered(),_(r.grid)])})),(0,t.t6)("reset-fasta",(async()=>{const n=await S("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),s="MD",o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid);const i=o.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{i.props=new X.n(s)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(i.props.substructure,s),(0,t.E3)(i.substructureInput.value,s),R()(o.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await _(r.grid),(0,t.E3)(i.props.substructure,""),(0,t.E3)(i.substructureInput.value,"")})),(0,t.t6)("reopen",(async()=>{const n=await Se.files.readCsv("tests/filter_FASTA.csv"),r=a.shell.addTableView(n),s=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:s});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid),o.close(),await _(r.grid);const i=await n.plot.fromType(e.VIEWER.FILTERS,{filters:s});r.dockManager.dock(i,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await _(r.grid)}))}));var Q=n(8152);class J{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var ee=n(9192);(0,t.L1)("PepSeA",(()=>{(0,t.gM)((async()=>{await(0,b.m8)()})),(0,t.t6)("Basic alignment",(async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,Q.GD)(n.getCol("HELM"),"msa(HELM)"),s=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==s.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new J,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),s=await(0,Q.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),o=r.getCol("MSA");(0,t.J6)(s.toList(),o.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")}),{timeout:6e4,stressTest:!0}),(0,t.t6)("error",(async()=>{const n=new J;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,Q.GD)(t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,r]=(0,ee.AP)(e);n.error(t,void 0,r)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")}))})),(0,t.L1)("viewers",(()=>{const n=e.Func.find({package:"Bio",tags:["viewer"]}).map((e=>e.friendlyName));for(const e of n)(0,t.t6)(e,(async()=>{const n=await S("samples/FASTA_DNA.csv");await(0,t.Bl)(e,n,{detectSemanticTypes:!0})}),{skipReason:{"Sequence Similarity Search":"GROK-13162","Sequence Diversity Search":"GROK-13162",WebLogo:"GROK-13162",VdRegions:"GROK-13162"}[e]})}));const te="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",ne="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",re="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var se;(0,t.L1)("SeqHandler",(()=>{let n;async function r(t){const r=e.DataFrame.fromCsv(t);await a.data.detectSemanticTypes(r);const s=n.getSeqHandler(r.getCol("seq"));return[r,s]}(0,t.gM)((async()=>{n=await(0,l.Q)()})),(0,t.t6)("Seq-Fasta",(async()=>{const[e,n]=await r(te);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA",(async()=>{const[e,n]=await r(ne);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)})),(0,t.t6)("Seq-Fasta-units",(async()=>{const[e,n]=await r(te);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA-units",(async()=>{const[e,n]=await r(ne);(0,t.E3)(n.notation,c.Hi.FASTA),(0,t.E3)(n.isMsa(),!0)})),(0,t.t6)("Seq-Helm",(async()=>{const[e,n]=await r("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(n.notation,c.Hi.HELM),(0,t.E3)(n.isHelm(),!0)})),(0,t.t6)("Seq-UN",(async()=>{const[e,n]=await r(re);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)})),(0,t.t6)("Seq-UN-auto",(async()=>{const[e,n]=await r(re);(0,t.E3)(n.notation,c.Hi.SEPARATOR),(0,t.E3)(n.separator,"-"),(0,t.E3)(n.alphabet,c.YI.UN)})),(0,t.t6)("column-version",(async()=>{const r=e.DataFrame.fromCsv(te);await a.data.detectSemanticTypes(r);const s=r.getCol("seq"),o=n.getSeqHandler(s),i=s.version,c=n.getSeqHandler(s),l=s.version;(0,t.E3)(i,l,"Unexpected column version changed"),(0,t.E3)(o,c,"Unexpected SeqHandler object changed"),r.rows.addNew(["TACCCCTTCAAC"]);const u=n.getSeqHandler(s),d=s.version;(0,t.E3)(l<d,!0,"Stalled column version on add row"),(0,t.E3)(c!==u,!0,"Stalled SeqHandler object on add row"),s.set(1,"CAGTGTCCCCGT");const h=n.getSeqHandler(s),p=s.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(u!==h,!0,"Stalled SeqHandler object on change data"),s.setTag("testTag","testValue");const m=n.getSeqHandler(s),f=s.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),function(e){e.fasta="fasta",e.fastaMsa="fastaMsa",e.separator="separator",e.separatorMsa="separatorMsa",e.helm="helm"}(se||(se={})),(0,t.L1)("SeqHandler: splitted",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()})),Y.b9[c.Hi.FASTA],Y.b9[c.Hi.HELM];const r=Y.b9[c.Hi.SEPARATOR],s={[se.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[se.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[se.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[se.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",r,"abc1","dfgg","rut12","her2","rty",r,"abc1","dfgg"],["rut2","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],["rut3","rty","her2",r,r,"wert","rut12","rty","her2",r,r,"wert"],[r,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",r]]}},[se.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$"},tgt:{notation:c.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[r,o]of Object.entries(s))(0,t.t6)(`${r}`,(async()=>{const r=e.DataFrame.fromCsv(o.src.csv).getCol("seq"),s=await a.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s),(0,t.E3)(r.semType,e.SEMTYPE.MACROMOLECULE);const i=n.getSeqHandler(r);(0,t.E3)(i.notation,o.tgt.notation),(0,t.E3)(i.separator===o.tgt.separator,!0);const c=A().count(0).take(i.length).map((e=>{const t=i.getSplitted(e);return A().count(0).take(t.length).map((e=>t.getOriginal(e))).toArray()})).toArray();(0,t.J6)(c,o.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:c.Hi.FASTA,alphabet:c.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:c.Hi.SEPARATOR,alphabet:c.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 3, 4, 4A, 4A, 4C",start:"4",end:null}},helm:{srcCsv:"seq\nPEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn]}$$$$\nPEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro]}$$$$\nPEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T}$$$$",startIdx:3,endIdx:6,tgtCsv:"seq\nPEPTIDE1{N.T.[dE].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.[dK].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.*.*}$$$$",units:c.Hi.HELM,alphabet:null,positionNames:{tag:null,start:"4",end:"7"}}};for(const[s,o]of Object.entries(r))(0,t.t6)(`${s}-idx`,(async()=>{const r=e.DataFrame.fromCsv(o.srcCsv).getCol("seq"),s=await a.functions.call("Bio:detectMacromolecule",{col:r});s&&(r.semType=s);const i=n.getSeqHandler(r).getRegion(o.startIdx,o.endIdx,"regSeq"),l=e.DataFrame.fromCsv(o.tgtCsv).getCol("seq");(0,t.E3)(r.meta.units,o.units),(0,t.E3)(i.meta.units,o.units),(0,t.E3)(r.getTag(c.gp.alphabet),o.alphabet),(0,t.E3)(i.getTag(c.gp.alphabet),o.alphabet),(0,t.J6)(i.toList(),l.toList())})),o.positionNames&&(0,t.t6)(`${s}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(o.srcCsv).getCol("seq");o.positionNames.tag&&n.setTag(c.gp.positionNames,o.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=await a.functions.call("Bio:getRegion",{sequence:n,start:o.positionNames.start,end:o.positionNames.end}),i=e.DataFrame.fromCsv(o.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,o.units),(0,t.E3)(s.meta.units,o.units),(0,t.E3)(n.getTag(c.gp.alphabet),o.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),o.alphabet),(0,t.J6)(s.toList(),i.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r,s;(0,t.gM)((async()=>{n=await(0,l.Q)(),r=await(0,T.pj)(),s=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await r.loadMonomerLib(!0)}));const o={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(o))(0,t.t6)(e,(async()=>{await i(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function i(r,s,o,i){const c=e.Column.fromStrings("seq",[r]),l=e.DataFrame.fromColumns([c]);await a.data.detectSemanticTypes(l);const u=n.getSeqHandler(c),d=(await u.getHelm(0)).value;(0,t.E3)(d,i)}}));var oe=n(6956);class ie{constructor(e){const t=e.split(oe.xe);t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],r=t.split(",");r[2].split("-").forEach(((e,t)=>{const s=r[t],o=e.split(":"),i={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:s,bond:i})})),e.push(n)})),e}}class ae{simplePolymer;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],r=[];return t.forEach((e=>{n.push(e),r.push("Backbone")})),{monomers:n,monomerTypes:r}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const r=t[n],s=t[n+1];e.push([{monomerIdx:r,rGroupId:2},{monomerIdx:s,rGroupId:1}])}for(let t=0;t<n.length;t++){const r=n[t],s=r-1;e.push([{monomerIdx:s,rGroupId:3},{monomerIdx:r,rGroupId:1}])}return e}}class ce{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(oe.pk),n=t[0].split(oe.xe);this.simplePolymers=n.map((e=>new ae(e))),""!==t[1]&&(this.connectionList=new ie(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,r=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(r)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const r=Object.keys(t).find((e=>t[e]===n));return 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e={"single-linear":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T.[meI]}$$$$"},tgt:{simplePolymers:[6],bondedRGroups:[1,2,2,2,2,1]}},"single-cyclized-C-2-2":{src:{helm:"PEPTIDE1{R.F.C.Y.G.H.[GGaz].C.T.[meI]}$PEPTIDE1,PEPTIDE1,3:R3-8,R3$$$"},tgt:{simplePolymers:[10],bondedRGroups:[1,2,3,2,2,2,2,3,2,1]}},"single-cyclized-C-1-1":{src:{helm:"PEPTIDE1{F.C.Y.G.H.[GGaz].C.[meI]}$PEPTIDE1,PEPTIDE1,2:R3-7,R3$$$"},tgt:{simplePolymers:[8],bondedRGroups:[1,3,2,2,2,1,3,1]}},"single-cyclized-C-0-0":{src:{helm:"PEPTIDE1{C.Y.G.H.[GGaz].C}$PEPTIDE1,PEPTIDE1,2:R3-7,R3$$$"},tgt:{simplePolymers:[6],bondedRGroups:[2,2,2,2,2,2]}},"two-separated-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$$$$"},tgt:{simplePolymers:[5,1],bondedRGroups:[1,2,2,2,1,1]}},"two-separated-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$$$$"},tgt:{simplePolymers:[4,2],bondedRGroups:[1,2,2,1,1,1]}},"two-connected-1":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz].T}|PEPTIDE2{[meI]}$PEPTIDE1,PEPTIDE2,5:R2-1,R1$$$"},tgt:{simplePolymers:[5,1],bondedRGroups:[1,2,2,2,2,1]}},"two-connected-2":{src:{helm:"PEPTIDE1{R.F.Y.[GGaz]}|PEPTIDE2{T.[meI]}$PEPTIDE1,PEPTIDE2,4:R2-1,R1$$$"},tgt:{simplePolymers:[4,2],bondedRGroups:[1,2,2,2,2,1]}}};for(const[n,{src:r,tgt:s}]of Object.entries(e))(0,t.t6)(n,(async()=>{const e=new ce(r.helm),n=e.simplePolymers.map((e=>e.monomers.length)),o=n.reduce(((e,t)=>e+t),0);(0,t.E3)(n,s.simplePolymers);const i=A().count(0).take(e.bondedRGroupsMap.size).map((t=>e.bondedRGroupsMap.get(t).length)).toArray();(0,t.E3)(o,i.length)}),{skipReason:"new tests"})}));var le=n(6077),ue=n(6717);const de=new e.FileSource("System:AppData/Bio"),he={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},pe="molfile(sequence)";function me(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map((e=>e.trimEnd())).join("\n")}(0,t.L1)("toAtomicLevel",(async()=>{const n={},r={};let s,o,i,u,d,h;async function p(e,n){const r=e.getCol("sequence");await a.functions.call("Bio:toAtomicLevel",{table:e,seqCol:r,nonlinear:!1});const s=e.getCol(pe),o=n.getCol(pe),i=A()(s.values()).map((e=>me(e))).toArray(),c=A()(o.values()).map((e=>me(e))).toArray();(0,t.J6)(i,c)}(0,t.gM)((async()=>{d=await(0,ue.j)(),i=await(0,l.Q)(),s=await(0,T.pj)(),o=await(0,N.ub)(),await s.loadMonomerLibForTests(),u=s.getMonomerLib();for(const[t,s]of Object.entries(he))s.inPath,n[t]=e.DataFrame.fromCsv((await de.readAsText(s.inPath)).replace(/\n$/,"")),await a.data.detectSemanticTypes(n[t]),r[t]=e.DataFrame.fromCsv((await de.readAsText(s.outPath)).replace(/\n$/,""))})),(0,t.Pl)((async()=>{await(0,N.Eu)(o),await s.loadMonomerLib(!0)}));for(const[e,s]of Object.entries(he))(0,t.t6)(`${e}`,(async()=>{await p(n[e],r[e])}));!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(h||(h={}));const m={[h.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[h.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[h.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[h.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[h.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[h.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[h.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[h.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[h.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function f(t){const n=m[t],r=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await a.data.detectSemanticTypes(r),r}async function g(e,t="seq",n){const r=e.getCol(t),s=await(0,le.C4)(e,r,u,i,d);return s.warnings.length>0&&Se.logger.warning(`_toAtomicLevel() warnings ${s.warnings.join("\n")}`),s.molCol}(0,t.t6)("fastaDna",(async()=>{await g(await f(h.fastaDna),"seq")})),(0,t.t6)("fastaRna",(async()=>{await g(await f(h.fastaRna),"seq")})),(0,t.t6)("fastaPt",(async()=>{await g(await f(h.fastaPt),"seq")})),(0,t.t6)("fastaUn",(async()=>{await g(await f(h.fastaUn),"seq")})),(0,t.t6)("separatorDna",(async()=>{await g(await f(h.separatorDna),"seq")})),(0,t.t6)("separatorDna",(async()=>{await g(await f(h.separatorRna),"seq")})),(0,t.t6)("separatorPt",(async()=>{await g(await f(h.separatorPt),"seq")})),(0,t.t6)("separatorUn",(async()=>{await g(await f(h.separatorUn),"seq")})),(0,t.t6)("helm",(async()=>{await g(await f(h.helm),"seq")})),(0,t.t6)("ptFasta2",(async()=>{const n=await Se.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),r=e.DataFrame.fromCsv("seq\nAR"),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=c.Hi.FASTA,s.setTag(c.gp.alphabet,c.YI.PT),i.getSeqHandler(s);const o=await g(r,"seq");(0,t.E3)(me(o.get(0)),me(n))}))}));var fe=n(8754);(0,t.L1)("toAtomicLevel-ui",(()=>{let n,r,s,o,i;(0,t.gM)((async()=>{s=await(0,l.Q)(),i=await(0,ue.j)(),n=await(0,T.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests(),o=n.getMonomerLib()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const u={fasta:{src:{seq:"MDYKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},"fasta-with-gap":{src:{seq:"MD-YKETLLMPK",units:c.Hi.FASTA},tgt:{atomCount:94,bondCount:95}},helm:{src:{seq:"PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}},"helm-with-gap":{src:{seq:"PEPTIDE1{meI.hHis.*.Aca.N.T.dK.Thr_PO3H2}$$$$",units:c.Hi.HELM},tgt:{atomCount:68,bondCount:68}}},d=async t=>{const n=t.src.seq,r=e.DataFrame.fromColumns([e.Column.fromList(e.COLUMN_TYPE.STRING,"seq",[n])]);return await a.data.detectSemanticTypes(r),r.getCol("seq")};for(const[e,n]of Object.entries(u))(0,t.t6)(`${e}-linear`,(async()=>{const e=await d(n);await h(e,!1,n.tgt)}));for(const[e,n]of Object.entries(u))(0,t.t6)(`${e}-nonlinear`,(async()=>{const e=await d(n);await h(e,!0,n.tgt)}));async function h(n,r,a){const c=await(0,fe.V)(n.dataFrame,n,r,!1,o,s,i);(0,t.E3)(c.molCol.semType,e.SEMTYPE.MOLECULE);const l=c.molCol.get(0),u=i.get_mol(l);(0,t.E3)(null!=u,!0,"No molecule generated");try{const e=u.get_num_atoms(),n=u.get_num_bonds();(0,t.E3)(e,a.atomCount),(0,t.E3)(n,a.bondCount)}finally{u.delete()}}}));var ge=n(6863);async function ye(t,n){const r=e.DataFrame.fromCsv(t),s=r.col("seq"),o=await a.functions.call("Bio:detectMacromolecule",{col:s});return o&&(s.semType=o),await a.data.detectSemanticTypes(r),n.getSeqHandler(s)}function be(e,n,r,s){const o=r(e,n);(0,t.E3)(Number(o.toFixed(3)),Number(s.toFixed(3)))}(0,t.L1)("Distance",(async()=>{let n;(0,t.gM)((async()=>{n=await(0,l.Q)()}));const r=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],s={F:0,W:1,R:2,Y:3},o="FWRWY",i="FWRWW",a="FWY",c="FWRWY",u="FWY",d="FWRRRRY";(0,t.t6)("protein-distance-function",(async()=>{const e=(await ye("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP",n)).getDistanceFunctionName();(0,t.E3)(e,ge.Z.LEVENSHTEIN)})),(0,t.t6)("DNA-distance-function",(async()=>{const e=(await ye("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA",n)).getDistanceFunctionName();(0,t.E3)(e,ge.Z.LEVENSHTEIN)})),(0,t.t6)("MSA-distance-function",(async()=>{const e=(await ye("seq\nATAACATAAC\nATCGAATCGA\nATCGAATCGA",n)).getDistanceFunctionName();(0,t.E3)(e,ge.Z.HAMMING)})),(0,t.t6)("levenstein-sub",(async()=>{const e=ge.V[ge.Z.LEVENSHTEIN]();be(o,i,e,.2)})),(0,t.t6)("levenstein-del",(async()=>{const e=ge.V[ge.Z.LEVENSHTEIN]();be(a,c,e,.4)})),(0,t.t6)("hamming",(async()=>{const e=ge.V[ge.Z.HAMMING]();be(a,c,e,.6)})),(0,t.t6)("needleman-blosum62",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});be(o,i,e,-6)})),(0,t.t6)("needleman-blosum62-del",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});be(a,c,e,-3.667)})),(0,t.t6)("needleman-custom-sub",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:r,alphabetIndexes:s,gapOpen:1,gapExtend:1});be(o,i,e,.2)})),(0,t.t6)("needleman-custom-del",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:r,alphabetIndexes:s,gapOpen:1,gapExtend:1});be(a,c,e,.667)})),(0,t.t6)("needleman-custom-zero-extend",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:r,alphabetIndexes:s,gapOpen:1,gapExtend:0});be(u,d,e,.333)})),(0,t.t6)("needleman-custom-half-extend",(async()=>{const e=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:r,alphabetIndexes:s,gapOpen:2,gapExtend:1});be(u,d,e,1.667)})),(0,t.t6)("needleman-custom-same-extend",(async()=>{const t=ge.V[ge.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:r,alphabetIndexes:s,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?be(Array(1e3).fill(u).join(""),Array(1e3).fill(d).join(""),t,1.333):be(u,d,t,1.333)}),{benchmark:!0})}));var we=n(684);async function ve(e,n,r,s,o,i,c,l){await a.data.detectSemanticTypes(e);const u=await a.functions.call("Bio:activityCliffs",{table:e,molecules:e.getCol(r),activities:e.getCol(s),similarity:o,methodName:n,similarityMetric:c,preprocessingFunction:l,options:{[`${we.vb}`]:!0},demo:!1});(0,t.E3)(null!=u,!0);const d=Array.from(u.root.children).find((e=>{const t=e.className.split(" ");return["ui-btn","ui-btn-ok"].every((e=>t.includes(e)))}));(0,t.E3)(d.innerText.toLowerCase(),`${i} cliffs`)}var Ae=n(2780),Ee=n(9039),Te=n(9124);async function Ce(n,r,s){const o=n.getCol(s),i=await a.functions.call("Bio:detectMacromolecule",{col:o});i&&(o.semType=i);const c=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!c)throw new Error("Preprocessing function not found");const l=await a.functions.call("Bio:sequenceSpaceTopMenu",{table:n,molecules:n.col(s),methodName:r,similarityMetric:ge.Z.LEVENSHTEIN,plotEmbeddings:!0,preprocessingFunction:c,options:{[we.vb]:!0}});(0,t.E3)(null!=l,!0)}(0,t.L1)("activityCliffs",(async()=>{let n,r,s;const o=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],i=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)((async()=>{n=await(0,Te.b2)(),r=await(0,T.pj)(),s=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await r.loadMonomerLib(!0)})),(0,t.t6)("activityCliffsOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv",tgt:{cliffCount:53}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await S(t.fileName);a.shell.addTableView(n),await ve(n,Ee.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,ge.Z.LEVENSHTEIN,o)}),{benchmark:!0}),(0,t.t6)("activityCliffsWithEmptyRows",(async()=>{const e=await S("tests/100_3_clustests_empty_vals.csv");a.shell.addTableView(e),await ve(e,Ee.c.UMAP,"sequence","Activity",90,3,ge.Z.LEVENSHTEIN,o)})),(0,t.t6)("Helm",(async()=>{const e=await Se.files.readCsv("samples/HELM_50.csv");a.shell.addTableView(e),await ve(e,Ee.c.UMAP,"HELM","Activity",65,20,Ae.aT.Tanimoto,i)}))})),(0,t.L1)("sequenceSpace",(async()=>{let n,r,s,o;(0,t.t6)("sequenceSpaceOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await S(t.fileName),r=a.shell.addTableView(n),await Ce(n,Ee.c.UMAP,"sequence")}),{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",(async()=>{s=await S("tests/100_3_clustests_empty_vals.csv"),o=a.shell.addTableView(s),await Ce(s,Ee.c.UMAP,"sequence")}))})),(0,t.L1)("Scoring",(()=>{const n="sequence",r="expected_similarity",s="expected_identity",o=e.DataFrame.fromCsv(`${n},${r},${s}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.68,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.34,0.0`),i=o.getCol(n);i.meta.units=c.Hi.HELM,i.semType=e.SEMTYPE.MACROMOLECULE;const l=i.get(0);let u,d;(0,t.gM)((async()=>{u=await(0,T.pj)(),d=await(0,N.ub)(),await u.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(d),await u.loadMonomerLib(!0)})),(0,t.t6)("Identity",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:o,macromolecule:i,reference:l});for(let n=0;n<e.length;n++){const r=e.get(n),i=o.get(s,n);(0,t.Wj)(r,i,.01,`Wrong identity score for sequence at position ${n}`)}})),(0,t.t6)("Identity-shortReference",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:o,macromolecule:i,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$"});(0,t.E3)(A().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Identity-longReference",(async()=>{const e=await a.functions.call("Bio:sequenceIdentityScoring",{table:o,macromolecule:i,reference:"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$"});(0,t.E3)(A().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Similarity",(async()=>{const e=await a.functions.call("Bio:sequenceSimilarityScoring",{table:o,macromolecule:i,reference:l});for(let n=0;n<e.length;n++){const s=e.get(n),i=o.get(r,n);(0,t.Wj)(s,i,.01,`Wrong similarity score for sequence at position ${n}`)}}))}));const Se=new e.Package;async function _e(n,r,s,o){const i=await(0,t.N$)({category:n,test:r,testContext:s,stressTest:o});return e.DataFrame.fromObjects(i)}async function Pe(){await(0,t.Xb)(Se,Se.getModule("package-test.js"))}})(),bio_test=r})();
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