@datagrok/bio 2.15.11 → 2.15.13

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Files changed (8) hide show
  1. package/CHANGELOG.md +8 -0
  2. package/dist/package-test.js +1 -1
  3. package/dist/package-test.js.map +1 -1
  4. package/dist/package.js +1 -1
  5. package/dist/package.js.map +1 -1
  6. package/package.json +1 -1
  7. package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +14 -4
  8. package/src/viewers/web-logo-viewer.ts +2 -4
package/dist/package-test.js CHANGED
@@ -4,5 +4,5 @@ var bio_test;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>i});var r=n(7
4
4
  || ${a} === "boolean" || ${i} === null`).assign(c,o._`[${i}]`)}}r.else(),m(e),r.endIf(),r.if(o._`${c} !== undefined`,(()=>{r.assign(i,c),function({gen:e,parentData:t,parentDataProperty:n},r){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${n}]`,r)))}(e,c)}))}(e,t,a):m(e)}))}return l};const u=new Set(["string","number","integer","boolean","null"]);function d(e,t,n,r=c.Correct){const i=r===c.Correct?o.operators.EQ:o.operators.NEQ;let s;switch(e){case"null":return o._`${t} ${i} null`;case"array":s=o._`Array.isArray(${t})`;break;case"object":s=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":s=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":s=a();break;default:return o._`typeof ${t} ${i} ${e}`}return r===c.Correct?s:(0,o.not)(s);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,n?o._`isFinite(${t})`:o.nil)}}function h(e,t,n,r){if(1===e.length)return d(e[0],t,n,r);let i;const s=(0,a.toHash)(e);if(s.array&&s.object){const e=o._`typeof ${t} != "object"`;i=s.null?e:o._`!${t} || ${e}`,delete s.null,delete s.array,delete s.object}else i=o.nil;s.number&&delete s.integer;for(const e in s)i=(0,o.and)(i,d(e,t,n,r));return i}t.checkDataType=d,t.checkDataTypes=h;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:r}=e,i=(0,a.schemaRefOrVal)(e,r,"type");return{gen:t,keyword:"type",data:n,schema:r.type,schemaCode:i,schemaValue:i,parentSchema:r,params:{},it:e}}(e);(0,s.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const r=n(9029),i=n(4227);function s(e,t,n){const{gen:s,compositeRule:o,data:a,opts:c}=e;if(void 0===n)return;const l=r._`${a}${(0,r.getProperty)(t)}`;if(o)return void(0,i.checkStrictMode)(e,`default is ignored for: ${l}`);let u=r._`${l} === 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S(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(w(e),y(e))?function(e){const{schema:t,opts:n,gen:r}=e;f(e,(()=>{n.$comment&&t.$comment&&A(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),r.let(d.default.vErrors,null),r.let(d.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),v(e),function(e){const{gen:t,schemaEnv:n,validateName:r,ValidationError:i,opts:s}=e;n.$async?t.if(u._`${d.default.errors} === 0`,(()=>t.return(d.default.data)),(()=>t.throw(u._`new 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console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const r=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),C.call(this,b,e,"NOT SUPPORTED"),C.call(this,w,e,"DEPRECATED","warn"),this._metaOpts=x.call(this),e.formats&&S.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),T.call(this),e.validateFormats=r}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let r=p;"id"===n&&(r={...p},r.id=r.$id,delete r.$id),t&&e&&this.addMetaSchema(r,r[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const r=n(t);return"$async"in 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c.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:n,localRefs:l}),this._cache.set(a.schema,a),i&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),r&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):c.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{c.compileSchema.call(this,e)}finally{this.opts=t}}}function C(e,t,n,r="error"){for(const i in e){const s=i;s in t&&this.logger[r](`${n}: option ${i}. ${e[s]}`)}}function E(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function T(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function S(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function 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s=t.name("valid");n.forEach(((t,n)=>{if((0,r.alwaysValidSchema)(i,t))return;const o=e.subschema({keyword:"allOf",schemaProp:n},s);e.ok(s),e.mergeEvaluated(o)}))}};t.default=i},6505:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=r},2661:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?r.str`must contain at least ${e} valid item(s)`:r.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?r._`{minContains: ${e}}`:r._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:s,data:o,it:a}=e;let 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5
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0!==i.undirected&&(a=c(e,i.undirected,s,o),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function de(){this.A=null,this.B=null}function he(e,t,n,r,i){for(var s in r){var o=r[s],a=o.source,c=o.target,l=a===n?c:a;if(!t||!t.has(l.key)){var u=i(l.key,l.attributes);if(e&&u)return l.key}}}function pe(e,t,n,r,i){if("mixed"!==t){if("undirected"===t)return he(e,null,r,r.undirected,i);if("string"==typeof n)return he(e,null,r,r[n],i)}var s,o=new de;if("undirected"!==t){if("out"!==n){if(s=he(e,null,r,r.in,i),e&&s)return s;o.wrap(r.in)}if("in"!==n){if(s=he(e,o,r,r.out,i),e&&s)return s;o.wrap(r.out)}}if("directed"!==t&&(s=he(e,o,r,r.undirected,i),e&&s))return s}function me(e,t,n){var r=Object.keys(n),i=r.length,s=0;return new N((function(){var o=null;do{if(s>=i)return e&&e.wrap(n),{done:!0};var a=n[r[s++]],c=a.source,l=a.target;o=c===t?l:c,e&&e.has(o.key)&&(o=null)}while(null===o);return{done:!1,value:{neighbor:o.key,attributes:o.attributes}}}))}function fe(e,t,n,r,i){for(var s,o,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(s=h.next()).done;){var m=!1;if(o=s.value,"undirected"!==p)for(a in c=o.out){l=c[a];do{if(u=l.target,m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=o.undirected)if(!(t&&o.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=i(o.key,null,o.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new U('Graph.import: invalid serialized node. 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Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ce={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ee(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Te(e,t,n,r,i,s,o,a){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,o=""+o,a=a||{},!e.allowSelfLoops&&s===o)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(s),u=e._nodes.get(o);if(!c)throw new V("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(o,'" not found.'));var d={key:null,undirected:r,source:s,target:o,attributes:a};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new B("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[o]:void 0!==c.out[o]))throw new B("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(o,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,i,c,u,a);e._edges.set(i,h);var p=s===o;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=i,e.emit("edgeAdded",d),i}function Se(e,t,n,r,i,s,o,c,u){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new U("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(s=""+s,o=""+o,u&&(d=c,c=void 0),!e.allowSelfLoops&&s===o)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(s),f=e._nodes.get(o);if(!n&&(h=e._edges.get(i))){if(!(h.source.key===s&&h.target.key===o||r&&h.source.key===o&&h.target.key===s))throw new B("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(i,'" edge with "').concat(s,'" source & "').concat(o,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[o]:m.out[o]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var b={key:null,undirected:r,source:s,target:o,attributes:c};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new B("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));var w=!1,v=!1;m||(m=Ee(e,s,{}),w=!0,s===o&&(f=m,v=!0)),f||(f=Ee(e,o,{}),v=!0),h=new K(r,i,m,f,c),e._edges.set(i,h);var A=s===o;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,b.key=i,e.emit("edgeAdded",b),[i,!0,w,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,i=t.attributes,s=t.undirected,o=n===r;s?(n.undirectedDegree--,r.undirectedDegree--,o&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,o&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:i,source:n.key,target:r.key,undirected:s})}var xe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ce,e)).multi)throw new U("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new U('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new U("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?Y:"directed"===e.type?W:j;d(o(t),"NodeDataClass",r);var i="geid_"+we()+"_",s=0;return d(o(t),"_attributes",{}),d(o(t),"_nodes",new Map),d(o(t),"_edges",new Map),d(o(t),"_directedSize",0),d(o(t),"_undirectedSize",0),d(o(t),"_directedSelfLoopCount",0),d(o(t),"_undirectedSelfLoopCount",0),d(o(t),"_edgeKeyGenerator",(function(){var e;do{e=i+s++}while(t._edges.has(e));return e})),d(o(t),"_options",e),Ae.forEach((function(e){return d(o(t),e,t[e])})),h(o(t),"order",(function(){return t._nodes.size})),h(o(t),"size",(function(){return t._edges.size})),h(o(t),"directedSize",(function(){return t._directedSize})),h(o(t),"undirectedSize",(function(){return t._undirectedSize})),h(o(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(o(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(o(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(o(t),"multi",t._options.multi),h(o(t),"type",t._options.type),h(o(t),"allowSelfLoops",t._options.allowSelfLoops),h(o(t),"implementation",(function(){return"graphology"})),t}t(r,n);var i=r.prototype;return i._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},i.hasNode=function(e){return this._nodes.has(""+e)},i.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.out.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.undirected.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new U("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},i.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},i.edge=function(e,t){if(this.multi)throw new B("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},i.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},i.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},i.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},i.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},i.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},i.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},i.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},i.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},i.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},i.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},i.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},i.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},i.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},i.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},i.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},i.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},i.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},i.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},i.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},i.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},i.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},i.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},i.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},i.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},i.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,i=n.target.key;if(e===r)return i;if(e===i)return r;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(i,")."))},i.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},i.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},i.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},i.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},i.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new U('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new B('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},i.mergeNode=function(e,t){if(t&&!l(t))throw new U('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},i.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new U('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var i=t?t({}):{};return n=new this.NodeDataClass(e,i),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:i}),[e,!0]},i.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var i in n.in){t=n.in[i];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},i.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},i.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},i.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},i.getAttribute=function(e){return this._attributes[e]},i.getAttributes=function(){return this._attributes},i.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},i.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.updateAttribute=function(e,t){if("function"!=typeof t)throw new U("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},i.replaceAttributes=function(e){if(!l(e))throw new U("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},i.mergeAttributes=function(e){if(!l(e))throw new U("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},i.updateAttributes=function(e){if("function"!=typeof e)throw new U("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},i.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i=this._nodes.values();!0!==(n=i.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},i.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i,s,o=this._edges.values();!0!==(n=o.next()).done;)i=(r=n.value).source,s=r.target,r.attributes=e(r.key,r.attributes,i.key,s.key,i.attributes,s.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},i.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},i.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},i.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},i.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},i.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},i.forEachNode=function(e){if("function"!=typeof e)throw new U("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},i.findNode=function(e){if("function"!=typeof e)throw new U("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},i.mapNodes=function(e){if("function"!=typeof e)throw new U("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),i=new Array(this.order),s=0;!0!==(t=r.next()).done;)n=t.value,i[s++]=e(n.key,n.attributes);return i},i.someNode=function(e){if("function"!=typeof e)throw new U("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},i.everyNode=function(e){if("function"!=typeof e)throw new U("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},i.filterNodes=function(e){if("function"!=typeof e)throw new U("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),i=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&i.push(n.key);return i},i.reduceNodes=function(e,t){if("function"!=typeof e)throw new U("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new U("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,i=t,s=this._nodes.values();!0!==(n=s.next()).done;)i=e(i,(r=n.value).key,r.attributes);return i},i.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},i.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,i){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,i,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},i.import=function(e){var t,n,i,s,o,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,i,s,o){c?o?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):o?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new U("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new U("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(i=e.nodes,!Array.isArray(i))throw new U("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=i.length;t<n;t++){ge(s=i[t]);var u=s,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),i=e.edges,!Array.isArray(i))throw new U("Graph.import: invalid edges. 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r,i,s=n(4328),o=n(7389),a=n(6082),c=n(684),l=n(9039);(i=r||(r={})).EUCLIDEAN="EUCLIDEAN",i.MANHATTAN="MANHATTAN";var u=n(1858),d=n(5072),h=n.n(d),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),w=n(540),v=n.n(w),A=n(1113),C=n.n(A),E=n(7939),T={};T.styleTagTransform=C(),T.setAttributes=b(),T.insert=g().bind(null,"head"),T.domAPI=m(),T.insertStyleElement=v(),h()(E.A,T),E.A&&E.A.locals&&E.A.locals;var S=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};let _=null,x=null;Promise.resolve(),n(934),n(8903);const M="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;const P=rxjs.operators;n(6295);const L=e=>null==e;function N(e,t,n,r){if(n>e[e.length-1])return;const i=e.findIndex((e=>n<e));e.pop(),e.splice(i,0,n),t.pop(),t.splice(i,0,r)}class 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s=this.sp.getMarkerSize(this.lines.from[o])/2,a=this.sp.getMarkerSize(this.lines.to[o])/2,c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[o]),this.yAxisCol.get(this.lines.from[o])),l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[o]),this.yAxisCol.get(this.lines.to[o]));if(this.multipleLinesCounts[o]){const n=this.getLineLength(c.x,c.y,l.x,l.y),r=this.getPointOnDistance(c.x,c.y,l.x,l.y,a,n),u=this.getPointOnDistance(l.x,l.y,null==c?void 0:c.x,null==c?void 0:c.y,s,n),d=this.lines.from[o]>this.lines.to[o]?this.findControlPoint(this.multipleLinesCounts[o],r.x,r.y,u.x,u.y,o):this.findControlPoint(this.multipleLinesCounts[o],u.x,u.y,r.x,r.y,o);i=this.calculateDistToCurveLine(o,e,t,r,u,d)}else i=this.calculateDistToStraightLine(e,t,c,l);(!r&&null!==i&&i<5||r&&null!==i&&i<r)&&(r=i,n=o)}return n}calculateDistToStraightLine(e,t,n,r){const i=Math.min(n.x,r.x),s=Math.max(n.x,r.x),o=Math.min(n.y,r.y),a=Math.max(n.y,r.y);return e>=i-2&&e<=s+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,r):null}distToStraightLineSegment(e,t,n,r){const i=(e,t,n,r)=>Math.pow(e-n,2)+Math.pow(t-r,2),s=i(n.x,n.y,r.x,r.y);if(0==s)return i(e,t,n.x,n.y);let o=((e-n.x)*(r.x-n.x)+(t-n.y)*(r.y-n.y))/s;return o=Math.max(0,Math.min(1,o)),i(e,t,n.x+o*(r.x-n.x),n.y+o*(r.y-n.y))}calculateDistToCurveLine(e,t,n,r,i,s){const o=Math.min(r.x,i.x,s.x),a=Math.max(r.x,i.x,s.x),c=Math.min(r.y,i.y,s.y),l=Math.max(r.y,i.y,s.y);if(t>=o-2&&t<=a+2&&n>=c-2&&n<=l+2){const e=a-o,u=l-c;return this.calculateDistToCurveInRect(t,n,r,s,i,e,u)}return null}calculateDistToCurveInRect(e,t,n,r,i,s,o){const a=Math.floor((s+o)/3),c=1/a,l=new Uint32Array(a),u=new Uint32Array(a),d=new Uint32Array(a);let h=null;const p=new O.A(a);for(let s=0;s<l.length;s++){const o=s*c,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*r.x+Math.pow(o,2)*i.x,p=Math.pow(1-o,2)*n.y+2*o*(1-o)*r.y+Math.pow(o,2)*i.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!h||h>g)&&(h=g),d[s]=Math.max(m,f),l[s]=a,u[s]=p}for(let e=0;e<l.length;e++)d[e]<h&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const r=Math.hypot(l[n]-e,u[n]-t);(!m||m>r)&&(m=r)}return m}getLineLength(e,t,n,r){return Math.sqrt(Math.pow(n-e,2)+Math.pow(r-t,2))}getPointOnDistance(e,t,n,r,i,s){const o=n-i*((n-e)/s),c=r-i*((r-t)/s);return new a.Point(o,c)}findControlPoint(e,t,n,r,i,s){const o=t+(r-t)/2,c=n+(i-n)/2;let l=o-t,u=c-n;const d=Math.sqrt(l*l+u*u);l/=d,u/=d;const h=50*Math.ceil(e/2);return e%2==0?new a.Point(o+h/2*u,c-h/2*l):new a.Point(o-h/2*u,c+h/2*l)}canvasArrow(e,t,n,r,i){const s=Math.atan2(r-t,i-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(s-Math.PI/10),n-this.arrowWidth*Math.cos(s-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(s+Math.PI/10),n-this.arrowWidth*Math.cos(s+Math.PI/10))}}const D="dimensionality-reducer-terminate-event";var G,H,F=n(3629);async function U(e,t,r,i,o,a,c){let l=await async function(e,t,r,i,o,a,c){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==i.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(l,u){const d=new Worker(new URL(n.p+n.u(234),n.b));d.postMessage({columnsData:e,distanceMetrics:t,method:r,options:a,weights:i,aggregationMethod:o});const h=s.events.onCustomEvent(D).subscribe((()=>{try{d?.terminate()}finally{h.unsubscribe()}}));d.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:r}})=>{L(n)||L(r)?(h.unsubscribe(),e?u(e):l(t),setTimeout((()=>d.terminate()),100)):c&&c(n,r,t)}}))}(e,r,t,i,o,a,c);return l=l.map((e=>(0,F.S8)(e))),l}(H=G||(G={})).EUCLIDEAN="EUCLIDEAN",H.MANHATTAN="MANHATTAN";const V={[G.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[G.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var B,Y;(Y=B||(B={})).HAMMING="Hamming",Y.EUCLIDEAN="Euclidean",Y.MANHATTAN="Manhattan",Y.TANIMOTO="Tanimoto",Y.LEVENSTEIN="Levenshtein",Y.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Y.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Y.SOKAL="Sokal",Y.COSINE="Cosine",Y.ASYMMETRIC="Asymmetric",Y.Difference="Difference",Y.OneHot="One-Hot";const W={[B.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[B.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[B.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[B.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[B.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[B.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[B.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[B.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[B.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[B.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[B.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[B.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},j={[B.HAMMING]:e=>Math.ceil(e/30),[B.EUCLIDEAN]:e=>Math.ceil(e/30),[B.MANHATTAN]:e=>Math.ceil(e/30),[B.TANIMOTO]:e=>Math.ceil(e/60),[B.SOKAL]:e=>Math.ceil(e/60),[B.COSINE]:e=>Math.ceil(e/60),[B.ASYMMETRIC]:e=>Math.ceil(e/60),[B.LEVENSTEIN]:e=>Math.ceil(e*e/60),[B.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[B.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[B.Difference]:e=>1,[B.OneHot]:e=>Math.ceil(e/40)},K={STRING:new Set([B.HAMMING,B.LEVENSTEIN,B.NEEDLEMAN_WUNSCH,B.MONOMER_CHEMICAL_DISTANCE,B.OneHot]),UINT32ARRAY:new Set([B.HAMMING,B.EUCLIDEAN,B.MANHATTAN,B.MONOMER_CHEMICAL_DISTANCE,B.LEVENSTEIN,B.NEEDLEMAN_WUNSCH,B.TANIMOTO,B.COSINE,B.SOKAL,B.ASYMMETRIC,B.OneHot,B.Difference]),INT32ARRAY:new Set([B.EUCLIDEAN,B.MANHATTAN,B.OneHot,B.Difference]),FLOAT32ARRAY:new Set([B.EUCLIDEAN,B.MANHATTAN,B.Difference]),NUMBER:new Set([B.EUCLIDEAN,B.MANHATTAN,B.Difference]),BITARRAY:new Set([B.TANIMOTO,B.COSINE,B.SOKAL,B.ASYMMETRIC])};var z=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function q(e,t,n,r){return e.map(((e,r)=>`\n fn distanceScript${r}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${r}[aIndex];\n let b = computeInfo.data${r}[bIndex];\n let maxDistance: f32 = ${n};\n ${W[e](t[r],r)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${V[r](e.length)}\n }\n \n `}var Z=n(1991),X=n.n(Z);let J=0;const Q="cliffsDf",ee=new u.Subject,te="activity_difference",ne="SALI_index",re="similarity",ie="line_index",se=["1_molecule","2_molecule"],oe="filterCliffs";async function ae(e,t,r,i,c,l,u,d,h,p,m,f,g,y,b,w,v){J++;const A=l/100;let C,E=!1;const T=f.inputs,L=await f.apply({[T[0].name]:t,[T[1].name]:u,...h.preprocessingFuncArgs??{}});let N=[];if(d===M){const t=await function(e,t,r,i,s,o,a=10,c=!1,l=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let d;return u.postMessage({data:e,threshold:t,weights:r,aggregationMethod:i,distanceFns:s,distanceFnArgs:o,maxIterations:a,useWebGPU:c,inflate:l}),{promise:new Promise(((e,t)=>{d=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{d(null),u.terminate()}catch(e){console.error(e)}}}}([L.entries],l,[1],"MANHATTAN",[u],[L.options??{}],h?.maxIterations??5,h.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),N=[t.embedX,t.embedY]}else N=await U([L.entries],d,[u],[1],"MANHATTAN",{...h,distanceFnArgs:[L.options??{}]});if(N.length!==r.length)throw new Error("Number of axes 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array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${l}>,\n // the weights for each entry\n weights: array<f32, ${l}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${h}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> 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{\n return; // if we are done, return\n }\n for (var i = 0; i < ${w}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${c}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${q(n,d.map((e=>e.maxEntryLen)),c,r)}\n\n\n `}),M=o.createComputePipeline({label:"sparse matrix compute 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Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Re.TYPE)&&-1!==e.indexOf(Re.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Re.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Re.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Re.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Re.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Re.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Re.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ye extends Ve{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const i=t[1];if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class We{constructor(){}static getInstance(e){if(We.isMolfileV2K(e))return new Be(e);if(We.isMolfileV3K(e))return new Ye(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Be.isValidMolfile(e)}static isMolfileV3K(e){return Ye.isValidMolfile(e)}}var je=n(6197),Ke=n(9124),ze=n(3527);class qe{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",r=void 0,i=void 0,s=void 0,o){if(this.biotype=e,this.id=t,this.n=n,this.m=r,this.type=i,this.mt=s,this.smiles=o,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++qe.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ze extends qe{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Xe extends qe{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Je extends qe{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Qe extends qe{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class et{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,r,i,s,o,a){this.id=e,this.m=t,this.n=n,this.na=r,this.type=i,this.mt=s,this.at=o,this.smiles=a}static fromMonomer(e,t,n){let r={};const i=t.symbol,s=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{r[e.label]=e.capGroupName}));else{if(!s){if(t.lib)return new Qe(e,i);throw new Error("Unexpected missing monomer without .lib")}r=n.getRS(s)}const o=new et(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,r),a=n.getMonomerColors(e,t.symbol);return a&&(o.textcolor=a?.textcolor,o.linecolor=a?.linecolor,o.backgroundcolor=a?.backgroundcolor),o}}const tt={[Me.o.BASE]:{A:"green",G:"black",T:"red",C:"blue",U:"red"},[Me.o.NUCLEOTIDE]:{A:"green",G:"black",T:"red",C:"blue",U:"red"},[Me.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Me.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Me.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Me.o.CHEM]:{R:"#eeeeee"},[Me.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},nt=/[\w()]+/,rt=RegExp(String.raw`\(${nt}(,${nt})+\)`),it=new ze.Mi([255,255,255]),st=new ze.Mi([0,0,0]),ot=.7*(0,F.wQ)(it);class at{_monomers;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e){this._monomers=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length))}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t==fe._S||t===fe.b9[fe.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:X().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ot.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}getWebEditorMonomer(e,t){const[n,r]=(0,Ke.fA)(e,t),i=(0,je.Y)(n);let s=this.getMonomer(i,r);if(s&&n==Me.o.LINKER&&2!=s.rgroups.length)return null;if(s&&n==Me.o.SUGAR&&3!=s.rgroups.length)return null;s||(s=this.addMissingMonomer(i,r));let o=s.wem??null;return o||(r===fe._S||"*"==r?o=s.wem=new Ze(n):n===Me.o.NUCLEOTIDE&&"N"===r||n===Me.o.AA&&"X"===r||(Me.o.CHEM,0)||rt.test(r)?o=s.wem=new Xe(n,r):s.lib||(o=s.wem=new Je(n,r,this.isEmpty)),o||(o=s.wem=et.fromMonomer(n,s,this))),o}getTooltip(e,t){const n=(0,je.Y)(e),r=o.div([],{classes:"ui-form ui-tooltip"}),i=this.getMonomer(n,t);if(i){const n=i.symbol,a=(i.name,this.getWebEditorMonomer(e,t));a.backgroundcolor,r.append(o.divH([o.div([n],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:a.textcolor,backgroundColor:a.backgroundcolor,borderColor:a.linecolor,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),o.div([i.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const c={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let l;l=i.molfile?s.chem.svgMol(i.molfile,void 0,void 0,c):i.smiles?o.divV([s.chem.svgMol(i.smiles,void 0,void 0,c),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),r.append(o.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),i.symbol!=fe._S&&r.append(o.divText(i.lib?.source??"Missed in libraries"))}else r.append(o.divV([o.divText(`Monomer '${t}' of type '${n}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return r}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),r=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const r=a.Color.fromHtml(n.textcolor);return[a.Color.r(r),a.Color.g(r),a.Color.b(r)]},i=r(n.textcolor),s=new ze.Mi([...i.map((e=>e+1))]),o=(0,F.KE)(s,it)/((0,F.wQ)(s)*(0,F.wQ)(it)),c=r(n.backgroundcolor),l=new ze.Mi([...c.map((e=>e+.01))]);let u;u=(0,F.KE)(l,it)/((0,F.wQ)(l)*(0,F.wQ)(it))<o?c:i;let d=new ze.Mi(u);const h=(0,F.wQ)(d);return h>ot&&(d=(0,F.dC)(st,d,ot/h)),`rgb(${d[0]}, ${d[1]}, ${d[2]})`}getMonomerColors(e,t){const n="default";let r=n;const i=(0,je.Y)(e),s=this.getMonomer(i,t);let o;if(s){if(s.meta&&s.meta.colors){const e=s.meta.colors;n in e||(r="default"),o=e[r]}if(!o){const t=tt[e],n=t?.[s.symbol];n&&(o={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=s.naturalAnalog;if(!o&&t)return this.getMonomerColors(e,t)}return o||(o={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:o.text??o.textColor,linecolor:o.line??o.lineColor,backgroundcolor:o.background??o.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let r,i="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){r=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(i+=t[e][n]);n["R"+r]=i,i=""}return n}}var ct=n(5488),lt={};lt.styleTagTransform=C(),lt.setAttributes=b(),lt.insert=g().bind(null,"head"),lt.domAPI=m(),lt.insertStyleElement=v(),h()(ct.A,lt),ct.A&&ct.A.locals&&ct.A.locals;class ut extends at{source;error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){super(e),this.source=t,this.error=n;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?.[n]??null}else{Ot.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=(0,je.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=We.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Ee.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const i=e.duplicateMonomerPreferences[n][r],s=this.duplicateMonomers[n][r].find((e=>e.lib?.source===i));s?this._monomers[n][r]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of X().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}override(e){return new dt(e,this)}}class dt extends at{data;base;constructor(e,t){super(e),this.data=e,this.base=t}get onChanged(){return this.base.onChanged}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class ht{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,i){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=i;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class pt{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var mt=n(7433),ft=n.n(mt),gt=n(1913),yt=n.n(gt);class bt{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(ft())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});yt()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const i of e){const e=i.symbol??i.id??i.name??"#N/A";if(n=this.validateMonomerSchema(i),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,i,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${i.polymerType??""}-${e}`;r.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(s)}return n}}var wt=n(8604);class vt{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++vt.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await s.dapi.files.readAsText(wt.gt),i=JSON.parse(r),o=new bt(i);return new vt(o,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(wt.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(wt.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(wt.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(wt.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(wt.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),i=await r.readAsText(t);n=JSON.parse(i);const s={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(s[t]={},o.push(t)),s[t][n]=e})),new ut(s,t)}async loadSetFromFile(e,t,n){let r={};const i=new a.FileSource(t),s=await i.readAsText(n);r=JSON.parse(s);const o=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,i=n.polymerType,s=n.monomerType,o=n.set;return new ht(e,r,i,s,o)}));return new pt(o,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(wt.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${wt.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ot.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ot.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ot.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(wt.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ot.logger.debug(`${e}, OUT`)})),Ot.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(wt.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(wt.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(wt.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(wt.Es.length)))}}class At{constructor(){}static _instance;static getInstance(){return At._instance||(At._instance=new At),At._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,P.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Ct{logger;_monomerLib=new ut({},"MAIN");_monomerSets=new pt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=5e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Oe.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Ct.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Ct.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await vt.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Ee.ub)()]),i=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let s=0;const o=i.length,[a]=await Promise.all([Promise.all(i.map((e=>this.readLibrary(wt.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new ut({},e,n)})).finally((()=>{n.update(Math.round(100*++s/o),`Loading monomers ${s}/${o}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let r=0;const i=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(wt.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new pt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/i),`Loading monomers ${r}/${i}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await 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n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,s,c){for(const[l,u]of Object.entries(this._freqs))if(l!==o._S){const o=(0,i.zS)(l,5),d=u.bounds,h=d.left;let p=a.S$;c&&(p=c.getWebEditorMonomer(s,l).backgroundcolor),e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(h,d.top,d.width,d.height),e.fillStyle=p,e.textAlign="left",e.font=t;const m=e.measureText(o);e.setTransform(d.width/m.width,0,0,d.height/r,h,d.top),e.fillText(o,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e,t){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,d.F)(Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))),e,t)}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(c||(c={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(l||(l={})),s.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(u||(u={}));const m=new class{render=20};function f(e,t,n,r,i){let s=0,o=-1;for(;-1!=(o=n.findNext(o,!0));){const e=t.getSplitted(o),n=i.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&s++}return s}r.JsViewer},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>o,n:()=>s});var r=n(1858),i=n(3572);class s{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(i._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{onChanged=new r.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get 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r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,b.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,b.AP)(e),i=this._filterPanel;i.innerText="error",i.classList.add("d4-error"),r.tooltip.bind(i,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,w.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,w.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class E{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,i){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=i}}class T extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class S extends i.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++S.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(i.SEMTYPE.MACROMOLECULE)),d.G.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new _:this.notation===l.Hi.SEPARATOR?new x(this.column.getTag(l.gp.separator)):new A,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(i.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=i.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(C,new E(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class x extends m.O{emptyProps=new T("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new T(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("")}get filterPanel(){return 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a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("Sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=L.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,L.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),r=(0,p.importFasta)(n)[0],i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),console.log("Bio: tests/renderers/afterMsa, table view"),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${i.semType}", units="${i.meta.units}", cell.renderer="${i.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(i.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(i.meta.units,c.Hi.FASTA),(0,t.E3)(i.getTag(c.gp.aligned),"SEQ"),(0,t.E3)(i.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"sequence");const u=await(0,b.D)({col:i});await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),(0,t.E3)(u.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(u.meta.units,c.Hi.FASTA),(0,t.E3)(u.getTag(c.gp.aligned),"SEQ.MSA"),(0,t.E3)(u.getTag(c.gp.alphabet),c.YI.PT),(0,t.E3)(u.getTag(e.TAGS.CELL_RENDERER),"sequence"),l.G.forColumn(u)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const u=await(0,F.r)(i,c.Hi.SEPARATOR,"/");await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const d=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),l.G.forColumn(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const n=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),r=a.shell.addTableView(n);await P(r.grid);const i=n.getCol("sequence"),s=l.G.forColumn(i).convert(c.Hi.HELM);n.columns.add(s),await P(r.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=L.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const i=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==i)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${i}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const r=e.DataFrame.fromCsv(n);r.currentRowIdx=0;const i=a.shell.addTableView(r),s=r.plot.scatter({x:"x",y:"y"});i.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),P(i.grid,500)]);const o=s.root.getBoundingClientRect(),c=s.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:o.left+c.x,clientY:o.top+c.y}),u=D()(s.root).find("canvas").get()[0];await(0,t.PE)((0,G.fromEvent)(u,"mousemove"),(()=>{Se.logger.debug(`Test: event, currentRowIdx=${r.currentRowIdx}`),(0,t.E3)(D()(O.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await P(i.grid,500)}()}));const n="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var V=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,S.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const i={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(i))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),i=new V.Jy(null,n,Se.logger,3,(()=>({seqHandler:l.G.forColumn(n),monomerCharWidth:7,separatorWidth:12,monomerToShort:c.zS}))),s=r.testList;for(let e=0;e<n.length;++e)i.getCellMonomerLengths(e,1e4);const o=[];for(const[e,t]of E().enumerate(s)){const t={pos:i.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", \n"))}))})),(0,t.L1)("renderers: monomerPlacer",(()=>{const e=[10,20,30,40,50,60],n={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[r,i]of Object.entries(n))(0,t.t6)("hitBounds-"+r,(async()=>{const n=(0,V.Bb)(e,i.x);(0,t.E3)(n,i.tgt)}))})),(0,t.L1)("converters",(()=>{let n;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(n||(n={}));const r={[n.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[n.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[n.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[n.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[n.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[n.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[n.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[n.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[n.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[n.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[n.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[n.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[n.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[n.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[n.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[n.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[n.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[n.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},i=new Set(Object.values(c.gp));async function s(t){const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i}function o(e,n){if(e===c.Hi.SEPARATOR&&!n)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(r){const i=l.G.forColumn(r).convert(e,n);return(0,t.E3)(i.meta.units,e),i}}async function u(e,n,r){const o=(await s(e)).getCol("seq"),a=n(o),u=(await s(r)).getCol("seq");(0,t.J6)(a.toList(),u.toList());const d=l.G.forColumn(o),h=l.G.forColumn(a);for(const[e,n]of Object.entries(u.tags)){if(!i.has(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const r=a.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await u(n.fastaPt,o(c.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testFastaDnaToSeparator",(async()=>{await 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n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,re.GD)(n.getCol("HELM"),"msa(HELM)"),i=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==i.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new ie,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),i=await(0,re.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),s=r.getCol("MSA");(0,t.J6)(i.toList(),s.toList()),(0,t.E3)(n.warningList[0].message,"Mis not 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a.data.detectSemanticTypes(n);const r=n.getCol("seq"),i=l.G.forColumn(r),s=r.version,o=l.G.forColumn(r),c=r.version;(0,t.E3)(s,c,"Unexpected column version changed"),(0,t.E3)(i,o,"Unexpected SeqHandler object changed"),n.rows.addNew(["TACCCCTTCAAC"]);const u=l.G.forColumn(r),d=r.version;(0,t.E3)(c<d,!0,"Stalled column version on add row"),(0,t.E3)(o!==u,!0,"Stalled SeqHandler object on add row"),r.set(1,"CAGTGTCCCCGT");const h=l.G.forColumn(r),p=r.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(u!==h,!0,"Stalled SeqHandler object on change data"),r.setTag("testTag","testValue");const m=l.G.forColumn(r),f=r.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),function(e){e.fasta="fasta",e.fastaMsa="fastaMsa",e.separator="separator",e.separatorMsa="separatorMsa",e.helm="helm"}(le||(le={})),(0,t.L1)("SeqHandler",(()=>{j.b9[c.Hi.FASTA],j.b9[c.Hi.HELM];const n=j.b9[c.Hi.SEPARATOR],r={[le.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[le.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:c.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[le.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[le.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:c.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",n,"abc1","dfgg","rut12","her2","rty",n,"abc1","dfgg"],["rut2","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],["rut3","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],[n,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",n]]}},[le.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$"},tgt:{notation:c.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[n,i]of Object.entries(r))(0,t.t6)(`splitted-${n}`,(async()=>{const n=e.DataFrame.fromCsv(i.src.csv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r),(0,t.E3)(n.semType,e.SEMTYPE.MACROMOLECULE);const s=l.G.forColumn(n);(0,t.E3)(s.notation,i.tgt.notation),(0,t.E3)(s.separator===i.tgt.separator,!0);const o=E().count(0).take(s.length).map((e=>{const t=s.getSplitted(e);return E().count(0).take(t.length).map((e=>t.getOriginal(e))).toArray()})).toArray();(0,t.J6)(o,i.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{const n={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:c.Hi.FASTA,alphabet:c.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:c.Hi.SEPARATOR,alphabet:c.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 3, 4, 4A, 4A, 4C",start:"4",end:null}},helm:{srcCsv:"seq\nPEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn]}$$$$\nPEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro]}$$$$\nPEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T}$$$$",startIdx:3,endIdx:6,tgtCsv:"seq\nPEPTIDE1{N.T.[dE].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.[dK].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.*.*}$$$$",units:c.Hi.HELM,alphabet:null,positionNames:{tag:null,start:"4",end:"7"}}};for(const[r,i]of Object.entries(n))(0,t.t6)(`${r}-idx`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=l.G.forColumn(n).getRegion(i.startIdx,i.endIdx,"regSeq"),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(c.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())})),i.positionNames&&(0,t.t6)(`${r}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq");i.positionNames.tag&&n.setTag(c.gp.positionNames,i.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=await a.functions.call("Bio:getRegion",{sequence:n,start:i.positionNames.start,end:i.positionNames.end}),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(c.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(c.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,S.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const i={fasta:{src:{seq:"MDYKETMDYKET",notation:c.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:c.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:c.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(i))(0,t.t6)(e,(async()=>{await s(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function s(n,r,i,s){const o=e.Column.fromStrings("seq",[n]),c=e.DataFrame.fromColumns([o]);await a.data.detectSemanticTypes(c);const u=l.G.forColumn(o),d=await u.getHelm(0,!1);(0,t.E3)(d,s)}}));var ue=n(6077),de=n(6717);const he=new e.FileSource("System:AppData/Bio"),pe={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},me="molfile(sequence)";function fe(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map((e=>e.trimEnd())).join("\n")}(0,t.L1)("toAtomicLevel",(async()=>{const n={},r={};let i,s,o,u,d;async function h(e,n){const r=e.getCol("sequence");await a.functions.call("Bio:toAtomicLevel",{table:e,seqCol:r,nonlinear:!1});const i=e.getCol(me),s=n.getCol(me),o=E()(i.values()).map((e=>fe(e))).toArray(),c=E()(s.values()).map((e=>fe(e))).toArray();(0,t.J6)(o,c)}(0,t.gM)((async()=>{u=await(0,de.j)(),i=await(0,S.pj)(),s=await(0,N.ub)(),await i.loadMonomerLibForTests(),o=i.getMonomerLib();for(const[t,i]of Object.entries(pe))i.inPath,n[t]=e.DataFrame.fromCsv((await he.readAsText(i.inPath)).replace(/\n$/,"")),await a.data.detectSemanticTypes(n[t]),r[t]=e.DataFrame.fromCsv((await he.readAsText(i.outPath)).replace(/\n$/,""))})),(0,t.Pl)((async()=>{await(0,N.Eu)(s),await i.loadMonomerLib(!0)}));for(const[e,i]of Object.entries(pe))(0,t.t6)(`${e}`,(async()=>{await h(n[e],r[e])}));!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(d||(d={}));const p={[d.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[d.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[d.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[d.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[d.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[d.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[d.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[d.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[d.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async 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i.attributes[r],this.emit("edgeAttributesUpdated",{key:i.key,type:"remove",attributes:i.attributes,name:r}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new B("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new B("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new B("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!l(r))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return i.attributes=r,this.emit("edgeAttributesUpdated",{key:i.key,type:"replace",attributes:i.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new B("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new B("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - 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infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new B("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof r)throw new U("Graph.".concat(t,": provided updater is not a function."));return i.attributes=r(i.attributes),this.emit("edgeAttributesUpdated",{key:i.key,type:"update",attributes:i.attributes}),this}}}],X=N,J=D,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var r=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(r=t.next()).done)break;t=null}return r}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,r){var i=!1;for(var s in t)if(s!==r){var o=t[s];if(i=n(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&i)return o.key}}function ne(e,t,n,r){var i,s,o,a=!1;for(var c in t)if(c!==r){i=t[c];do{if(s=i.source,o=i.target,a=n(i.key,i.attributes,s.key,o.key,s.attributes,o.attributes,i.undirected),e&&a)return i.key;i=i.next}while(void 0!==i)}}function re(e,t){var n,r=Object.keys(e),i=r.length,s=0;return new N((function(){do{if(n)n=n.next;else{if(s>=i)return{done:!0};var o=r[s++];if(o===t){n=void 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n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,r){if(0!==t.size)for(var i,s,o="mixed"!==n&&n!==t.type,a="undirected"===n,c=!1,l=t._edges.values();!0!==(i=l.next()).done;)if(s=i.value,!o||s.undirected===a){var u=s,d=u.key,h=u.attributes,p=u.source,m=u.target;if(c=r(d,h,p.key,m.key,p.attributes,m.attributes,s.undirected),e&&c)return d}}function ce(e,t,n,r,i,s){var o,a=t?ne:te;if("undirected"!==n){if("out"!==r&&(o=a(e,i.in,s),e&&o))return o;if("in"!==r&&(o=a(e,i.out,s,r?void 0:i.key),e&&o))return o}if("directed"!==n&&(o=a(e,i.undirected,s),e&&o))return o}function le(e,t,n,r,i,s,o){var a,c=n?se:ie;if("undirected"!==t){if(void 0!==i.in&&"out"!==r&&(a=c(e,i.in,s,o),e&&a))return a;if(void 0!==i.out&&"in"!==r&&(r||i.key!==s)&&(a=c(e,i.out,s,o),e&&a))return a}if("directed"!==t&&void 0!==i.undirected&&(a=c(e,i.undirected,s,o),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function de(){this.A=null,this.B=null}function he(e,t,n,r,i){for(var s in r){var o=r[s],a=o.source,c=o.target,l=a===n?c:a;if(!t||!t.has(l.key)){var u=i(l.key,l.attributes);if(e&&u)return l.key}}}function pe(e,t,n,r,i){if("mixed"!==t){if("undirected"===t)return he(e,null,r,r.undirected,i);if("string"==typeof n)return he(e,null,r,r[n],i)}var s,o=new de;if("undirected"!==t){if("out"!==n){if(s=he(e,null,r,r.in,i),e&&s)return s;o.wrap(r.in)}if("in"!==n){if(s=he(e,o,r,r.out,i),e&&s)return s;o.wrap(r.out)}}if("directed"!==t&&(s=he(e,o,r,r.undirected,i),e&&s))return s}function me(e,t,n){var r=Object.keys(n),i=r.length,s=0;return new N((function(){var o=null;do{if(s>=i)return e&&e.wrap(n),{done:!0};var a=n[r[s++]],c=a.source,l=a.target;o=c===t?l:c,e&&e.has(o.key)&&(o=null)}while(null===o);return{done:!1,value:{neighbor:o.key,attributes:o.attributes}}}))}function fe(e,t,n,r,i){for(var s,o,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(s=h.next()).done;){var m=!1;if(o=s.value,"undirected"!==p)for(a in c=o.out){l=c[a];do{if(u=l.target,m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=o.undirected)if(!(t&&o.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=i(o.key,null,o.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new U('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new U("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!l(e))throw new U('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new U("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new U("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new U("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,we=(be=255&Math.floor(256*Math.random()),function(){return be++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ce={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ee(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Te(e,t,n,r,i,s,o,a){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,o=""+o,a=a||{},!e.allowSelfLoops&&s===o)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(s),u=e._nodes.get(o);if(!c)throw new V("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(o,'" not found.'));var d={key:null,undirected:r,source:s,target:o,attributes:a};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new B("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[o]:void 0!==c.out[o]))throw new B("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(o,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,i,c,u,a);e._edges.set(i,h);var p=s===o;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=i,e.emit("edgeAdded",d),i}function Se(e,t,n,r,i,s,o,c,u){if(!r&&"undirected"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new B("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new U("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(s=""+s,o=""+o,u&&(d=c,c=void 0),!e.allowSelfLoops&&s===o)throw new B("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(s),f=e._nodes.get(o);if(!n&&(h=e._edges.get(i))){if(!(h.source.key===s&&h.target.key===o||r&&h.source.key===o&&h.target.key===s))throw new B("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(i,'" edge with "').concat(s,'" source & "').concat(o,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[o]:m.out[o]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var b={key:null,undirected:r,source:s,target:o,attributes:c};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new B("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));var w=!1,v=!1;m||(m=Ee(e,s,{}),w=!0,s===o&&(f=m,v=!0)),f||(f=Ee(e,o,{}),v=!0),h=new K(r,i,m,f,c),e._edges.set(i,h);var A=s===o;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,b.key=i,e.emit("edgeAdded",b),[i,!0,w,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,i=t.attributes,s=t.undirected,o=n===r;s?(n.undirectedDegree--,r.undirectedDegree--,o&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,o&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:i,source:n.key,target:r.key,undirected:s})}var xe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ce,e)).multi)throw new U("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new U('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new U("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?Y:"directed"===e.type?W:j;d(o(t),"NodeDataClass",r);var i="geid_"+we()+"_",s=0;return d(o(t),"_attributes",{}),d(o(t),"_nodes",new Map),d(o(t),"_edges",new Map),d(o(t),"_directedSize",0),d(o(t),"_undirectedSize",0),d(o(t),"_directedSelfLoopCount",0),d(o(t),"_undirectedSelfLoopCount",0),d(o(t),"_edgeKeyGenerator",(function(){var e;do{e=i+s++}while(t._edges.has(e));return e})),d(o(t),"_options",e),Ae.forEach((function(e){return d(o(t),e,t[e])})),h(o(t),"order",(function(){return t._nodes.size})),h(o(t),"size",(function(){return t._edges.size})),h(o(t),"directedSize",(function(){return t._directedSize})),h(o(t),"undirectedSize",(function(){return t._undirectedSize})),h(o(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(o(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(o(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(o(t),"multi",t._options.multi),h(o(t),"type",t._options.type),h(o(t),"allowSelfLoops",t._options.allowSelfLoops),h(o(t),"implementation",(function(){return"graphology"})),t}t(r,n);var i=r.prototype;return i._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},i.hasNode=function(e){return this._nodes.has(""+e)},i.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.out.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.undirected.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new U("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},i.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new B("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},i.edge=function(e,t){if(this.multi)throw new B("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},i.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},i.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},i.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},i.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},i.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},i.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},i.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},i.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},i.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},i.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},i.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},i.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},i.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},i.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},i.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},i.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},i.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},i.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},i.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},i.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},i.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},i.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},i.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},i.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},i.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,i=n.target.key;if(e===r)return i;if(e===i)return r;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(i,")."))},i.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},i.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},i.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},i.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},i.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new U('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new B('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},i.mergeNode=function(e,t){if(t&&!l(t))throw new U('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},i.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new U('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var i=t?t({}):{};return n=new this.NodeDataClass(e,i),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:i}),[e,!0]},i.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var i in n.in){t=n.in[i];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},i.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},i.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new B("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new B("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},i.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},i.getAttribute=function(e){return this._attributes[e]},i.getAttributes=function(){return this._attributes},i.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},i.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.updateAttribute=function(e,t){if("function"!=typeof t)throw new U("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},i.replaceAttributes=function(e){if(!l(e))throw new U("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},i.mergeAttributes=function(e){if(!l(e))throw new U("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},i.updateAttributes=function(e){if("function"!=typeof e)throw new U("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},i.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i=this._nodes.values();!0!==(n=i.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},i.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i,s,o=this._edges.values();!0!==(n=o.next()).done;)i=(r=n.value).source,s=r.target,r.attributes=e(r.key,r.attributes,i.key,s.key,i.attributes,s.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},i.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},i.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},i.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},i.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},i.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):H(this._nodes.keys(),this._nodes.size)},i.forEachNode=function(e){if("function"!=typeof e)throw new U("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},i.findNode=function(e){if("function"!=typeof e)throw new U("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},i.mapNodes=function(e){if("function"!=typeof e)throw new U("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),i=new Array(this.order),s=0;!0!==(t=r.next()).done;)n=t.value,i[s++]=e(n.key,n.attributes);return i},i.someNode=function(e){if("function"!=typeof e)throw new U("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},i.everyNode=function(e){if("function"!=typeof e)throw new U("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},i.filterNodes=function(e){if("function"!=typeof e)throw new U("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),i=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&i.push(n.key);return i},i.reduceNodes=function(e,t){if("function"!=typeof e)throw new U("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new U("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,i=t,s=this._nodes.values();!0!==(n=s.next()).done;)i=e(i,(r=n.value).key,r.attributes);return i},i.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},i.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,i){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,i,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},i.import=function(e){var t,n,i,s,o,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,i,s,o){c?o?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):o?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new U("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new U("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(i=e.nodes,!Array.isArray(i))throw new U("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=i.length;t<n;t++){ge(s=i[t]);var u=s,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),i=e.edges,!Array.isArray(i))throw new U("Graph.import: invalid edges. Expecting an array.");for(t=0,n=i.length;t<n;t++){ye(o=i[t]);var m=o,f=m.source,g=m.target,y=m.attributes,b=m.undirected,w=void 0===b?p:b;"key"in o?(c?w?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:w?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,o.key,f,g,y):(c?w?this.mergeUndirectedEdge:this.mergeDirectedEdge:w?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},i.nullCopy=function(e){var t=new r(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},i.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var r=a({},e.attributes);e=new t.NodeDataClass(n,r),t._nodes.set(n,e)})),t},i.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new B('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new B("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new B("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,r=this.emptyCopy(e),i=this._edges.values();!0!==(t=i.next()).done;)Te(r,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return r},i.toJSON=function(){return this.export()},i.toString=function(){return"[object Graph]"},i.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var r={},i={};this._edges.forEach((function(e,n){var s,o=e.undirected?"--":"->",a="",c=e.source.key,l=e.target.key;e.undirected&&c>l&&(s=c,c=l,l=s);var u="(".concat(c,")").concat(o,"(").concat(l,")");n.startsWith("geid_")?t.multi&&(void 0===i[u]?i[u]=0:i[u]++,a+="".concat(i[u],". 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r,i,s=n(4328),o=n(7389),a=n(6082),c=n(684),l=n(9039);(i=r||(r={})).EUCLIDEAN="EUCLIDEAN",i.MANHATTAN="MANHATTAN";var u=n(1858),d=n(5072),h=n.n(d),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),w=n(540),v=n.n(w),A=n(1113),C=n.n(A),E=n(7939),T={};T.styleTagTransform=C(),T.setAttributes=b(),T.insert=g().bind(null,"head"),T.domAPI=m(),T.insertStyleElement=v(),h()(E.A,T),E.A&&E.A.locals&&E.A.locals;var S=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};let _=null,x=null;Promise.resolve(),n(934),n(8903);const M="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;const P=rxjs.operators;n(6295);const L=e=>null==e;function N(e,t,n,r){if(n>e[e.length-1])return;const i=e.findIndex((e=>n<e));e.pop(),e.splice(i,0,n),t.pop(),t.splice(i,0,r)}class 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multiColumnKNN(e,t,i=15,s,o,a=r.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((r,u)=>{const h=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=h&&r({knnDistances:new Array(0),knnIndexes:new Array(0)}),d[n].postMessage({values:e,startIdx:h,endIdx:p,fnNames:t,opts:s,nNeighbours:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),r({knnDistances:t,knnIndexes:i}))}}));const h=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(-1)))};for(const t of h)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)N(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,i=[],s,o=r.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,r=Math.floor(n/this._workerCount),c=1e6,l=Math.max(Math.min(n/1e3,c),Math.min(n,c)),u=Math.floor(l/this._workerCount),d=new Array(this._workerCount);for(let c=0;c<this._workerCount;c++)d[c]=new Promise(((l,d)=>{const h=c*r,p=c===this._workerCount-1?n:(c+1)*r;a[c].postMessage({values:e,startIdx:h,endIdx:p,sampleLength:u,fnNames:t,opts:i,weights:s,aggregationMethod:o}),a[c].onmessage=({data:{error:e,distance:t}})=>{a[c].terminate(),e?d(e):l({distance:t})}}));const h=await 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i=this.getPointOnDistance(v,A,E,T,r,t),s=this.getPointOnDistance(E,T,v,A,n,t);v=i.x,A=i.y,E=s.x,T=s.y,C=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,v,A,E,T,e):this.findControlPoint(b,E,T,v,A,e),this.ctx.moveTo(v,A),this.ctx.quadraticCurveTo(C.x,C.y,E,T)}else(!this.lines.skipShortLines||Math.pow(E-v,2)+Math.pow(T-A,2)>w)&&(this.ctx.moveTo(v,A),this.ctx.lineTo(E,T));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(v,A,E,T)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(v,A,E,T,r,t),n=b?C.x:v,i=b?C.y:A;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:v,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:A,n,i)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case 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s=this.sp.getMarkerSize(this.lines.from[o])/2,a=this.sp.getMarkerSize(this.lines.to[o])/2,c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[o]),this.yAxisCol.get(this.lines.from[o])),l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[o]),this.yAxisCol.get(this.lines.to[o]));if(this.multipleLinesCounts[o]){const n=this.getLineLength(c.x,c.y,l.x,l.y),r=this.getPointOnDistance(c.x,c.y,l.x,l.y,a,n),u=this.getPointOnDistance(l.x,l.y,null==c?void 0:c.x,null==c?void 0:c.y,s,n),d=this.lines.from[o]>this.lines.to[o]?this.findControlPoint(this.multipleLinesCounts[o],r.x,r.y,u.x,u.y,o):this.findControlPoint(this.multipleLinesCounts[o],u.x,u.y,r.x,r.y,o);i=this.calculateDistToCurveLine(o,e,t,r,u,d)}else i=this.calculateDistToStraightLine(e,t,c,l);(!r&&null!==i&&i<5||r&&null!==i&&i<r)&&(r=i,n=o)}return n}calculateDistToStraightLine(e,t,n,r){const i=Math.min(n.x,r.x),s=Math.max(n.x,r.x),o=Math.min(n.y,r.y),a=Math.max(n.y,r.y);return e>=i-2&&e<=s+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,r):null}distToStraightLineSegment(e,t,n,r){const i=(e,t,n,r)=>Math.pow(e-n,2)+Math.pow(t-r,2),s=i(n.x,n.y,r.x,r.y);if(0==s)return i(e,t,n.x,n.y);let o=((e-n.x)*(r.x-n.x)+(t-n.y)*(r.y-n.y))/s;return o=Math.max(0,Math.min(1,o)),i(e,t,n.x+o*(r.x-n.x),n.y+o*(r.y-n.y))}calculateDistToCurveLine(e,t,n,r,i,s){const o=Math.min(r.x,i.x,s.x),a=Math.max(r.x,i.x,s.x),c=Math.min(r.y,i.y,s.y),l=Math.max(r.y,i.y,s.y);if(t>=o-2&&t<=a+2&&n>=c-2&&n<=l+2){const e=a-o,u=l-c;return this.calculateDistToCurveInRect(t,n,r,s,i,e,u)}return null}calculateDistToCurveInRect(e,t,n,r,i,s,o){const a=Math.floor((s+o)/3),c=1/a,l=new Uint32Array(a),u=new Uint32Array(a),d=new Uint32Array(a);let h=null;const p=new O.A(a);for(let s=0;s<l.length;s++){const o=s*c,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*r.x+Math.pow(o,2)*i.x,p=Math.pow(1-o,2)*n.y+2*o*(1-o)*r.y+Math.pow(o,2)*i.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!h||h>g)&&(h=g),d[s]=Math.max(m,f),l[s]=a,u[s]=p}for(let e=0;e<l.length;e++)d[e]<h&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const r=Math.hypot(l[n]-e,u[n]-t);(!m||m>r)&&(m=r)}return m}getLineLength(e,t,n,r){return Math.sqrt(Math.pow(n-e,2)+Math.pow(r-t,2))}getPointOnDistance(e,t,n,r,i,s){const o=n-i*((n-e)/s),c=r-i*((r-t)/s);return new a.Point(o,c)}findControlPoint(e,t,n,r,i,s){const o=t+(r-t)/2,c=n+(i-n)/2;let l=o-t,u=c-n;const d=Math.sqrt(l*l+u*u);l/=d,u/=d;const h=50*Math.ceil(e/2);return e%2==0?new a.Point(o+h/2*u,c-h/2*l):new a.Point(o-h/2*u,c+h/2*l)}canvasArrow(e,t,n,r,i){const s=Math.atan2(r-t,i-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(s-Math.PI/10),n-this.arrowWidth*Math.cos(s-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(s+Math.PI/10),n-this.arrowWidth*Math.cos(s+Math.PI/10))}}const D="dimensionality-reducer-terminate-event";var G,H,F=n(3629);async function U(e,t,r,i,o,a,c){let l=await async function(e,t,r,i,o,a,c){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==i.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(l,u){const d=new Worker(new URL(n.p+n.u(234),n.b));d.postMessage({columnsData:e,distanceMetrics:t,method:r,options:a,weights:i,aggregationMethod:o});const h=s.events.onCustomEvent(D).subscribe((()=>{try{d?.terminate()}finally{h.unsubscribe()}}));d.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:r}})=>{L(n)||L(r)?(h.unsubscribe(),e?u(e):l(t),setTimeout((()=>d.terminate()),100)):c&&c(n,r,t)}}))}(e,r,t,i,o,a,c);return l=l.map((e=>(0,F.S8)(e))),l}(H=G||(G={})).EUCLIDEAN="EUCLIDEAN",H.MANHATTAN="MANHATTAN";const V={[G.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[G.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var B,Y;(Y=B||(B={})).HAMMING="Hamming",Y.EUCLIDEAN="Euclidean",Y.MANHATTAN="Manhattan",Y.TANIMOTO="Tanimoto",Y.LEVENSTEIN="Levenshtein",Y.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",Y.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",Y.SOKAL="Sokal",Y.COSINE="Cosine",Y.ASYMMETRIC="Asymmetric",Y.Difference="Difference",Y.OneHot="One-Hot";const W={[B.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[B.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[B.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[B.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[B.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[B.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[B.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[B.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[B.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[B.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[B.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[B.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},j={[B.HAMMING]:e=>Math.ceil(e/30),[B.EUCLIDEAN]:e=>Math.ceil(e/30),[B.MANHATTAN]:e=>Math.ceil(e/30),[B.TANIMOTO]:e=>Math.ceil(e/60),[B.SOKAL]:e=>Math.ceil(e/60),[B.COSINE]:e=>Math.ceil(e/60),[B.ASYMMETRIC]:e=>Math.ceil(e/60),[B.LEVENSTEIN]:e=>Math.ceil(e*e/60),[B.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[B.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[B.Difference]:e=>1,[B.OneHot]:e=>Math.ceil(e/40)},K={STRING:new Set([B.HAMMING,B.LEVENSTEIN,B.NEEDLEMAN_WUNSCH,B.MONOMER_CHEMICAL_DISTANCE,B.OneHot]),UINT32ARRAY:new Set([B.HAMMING,B.EUCLIDEAN,B.MANHATTAN,B.MONOMER_CHEMICAL_DISTANCE,B.LEVENSTEIN,B.NEEDLEMAN_WUNSCH,B.TANIMOTO,B.COSINE,B.SOKAL,B.ASYMMETRIC,B.OneHot,B.Difference]),INT32ARRAY:new Set([B.EUCLIDEAN,B.MANHATTAN,B.OneHot,B.Difference]),FLOAT32ARRAY:new Set([B.EUCLIDEAN,B.MANHATTAN,B.Difference]),NUMBER:new Set([B.EUCLIDEAN,B.MANHATTAN,B.Difference]),BITARRAY:new Set([B.TANIMOTO,B.COSINE,B.SOKAL,B.ASYMMETRIC])};var z=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function q(e,t,n,r){return e.map(((e,r)=>`\n fn distanceScript${r}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${r}[aIndex];\n let b = computeInfo.data${r}[bIndex];\n let maxDistance: f32 = ${n};\n ${W[e](t[r],r)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${V[r](e.length)}\n }\n \n `}var Z=n(1991),X=n.n(Z);let J=0;const Q="cliffsDf",ee=new u.Subject,te="activity_difference",ne="SALI_index",re="similarity",ie="line_index",se=["1_molecule","2_molecule"],oe="filterCliffs";async function ae(e,t,r,i,c,l,u,d,h,p,m,f,g,y,b,w,v){J++;const A=l/100;let C,E=!1;const T=f.inputs,L=await f.apply({[T[0].name]:t,[T[1].name]:u,...h.preprocessingFuncArgs??{}});let N=[];if(d===M){const t=await function(e,t,r,i,s,o,a=10,c=!1,l=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let d;return u.postMessage({data:e,threshold:t,weights:r,aggregationMethod:i,distanceFns:s,distanceFnArgs:o,maxIterations:a,useWebGPU:c,inflate:l}),{promise:new Promise(((e,t)=>{d=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{d(null),u.terminate()}catch(e){console.error(e)}}}}([L.entries],l,[1],"MANHATTAN",[u],[L.options??{}],h?.maxIterations??5,h.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),N=[t.embedX,t.embedY]}else N=await U([L.entries],d,[u],[1],"MANHATTAN",{...h,distanceFnArgs:[L.options??{}]});if(N.length!==r.length)throw new Error("Number of axes 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array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${l}>,\n // the weights for each entry\n weights: array<f32, ${l}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${h}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> 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this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Ve extends Ue{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let r=0;r<t;r++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Be extends Ve{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Re.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,r]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,r)}}));const n=t.map(((e,t)=>{if(e.startsWith(Re.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),r=n.map((e=>t[e])),i=n.map((e=>t[e+1]));r.forEach(((t,n)=>{const r=parseInt(t.split(/\s+/)[1])-1,s=parseInt(i[n].substring(1));if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,r)}));const s=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==s.length)throw new Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Re.TYPE)&&-1!==e.indexOf(Re.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Re.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Re.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Re.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Re.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Re.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Re.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ye extends Ve{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const i=t[1];if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class We{constructor(){}static getInstance(e){if(We.isMolfileV2K(e))return new Be(e);if(We.isMolfileV3K(e))return new Ye(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Be.isValidMolfile(e)}static isMolfileV3K(e){return Ye.isValidMolfile(e)}}var je=n(6197),Ke=n(9124),ze=n(3527);class qe{biotype;id;n;m;type;mt;smiles;get issmiles(){return!!this.smiles}at={R1:"H",R2:"H",R3:"H",R4:"H",R5:"H",R6:"H",R7:"H",R8:"H",R9:"H"};get rs(){return Object.keys(this.at).length}constructor(e,t,n="missing",r=void 0,i=void 0,s=void 0,o){if(this.biotype=e,this.id=t,this.n=n,this.m=r,this.type=i,this.mt=s,this.smiles=o,!this.id)throw new Error("Invalid arg undefined [id].")}static objCounter=-1;objId=++qe.objCounter;className="WebEditorMonomerDummy";toLog(){return`Helm: ${this.className}<${this.objId}>`}}class Ze extends qe{backgroundcolor="#FFFFFF";linecolor="#808080";textcolor="#808080";constructor(e){super(e,"*","gap")}}class Xe extends qe{backgroundcolor="#808080";linecolor="#000000";textcolor="#000000";constructor(e,t){super(e,t,"ambiguous")}}class Je extends qe{backgroundcolor="#FF4444";linecolor="#800000";textcolor="#FFFFFF";constructor(e,t,n){super(e,t,"missing"),n&&(this.backgroundcolor="#C0C0C0",this.linecolor="#404040",this.textcolor="#404040")}}class Qe extends qe{backgroundcolor="#FFFF44";linecolor="#800000";textcolor="#000000";constructor(e,t){super(e,t,"broken")}}class et{id;m;n;na;type;mt;at;smiles;get rs(){return Object.keys(this.at).length}get issmiles(){return!!this.smiles}linecolor;backgroundcolor;textcolor;constructor(e,t,n,r,i,s,o,a){this.id=e,this.m=t,this.n=n,this.na=r,this.type=i,this.mt=s,this.at=o,this.smiles=a}static fromMonomer(e,t,n){let r={};const i=t.symbol,s=t.smiles;if(t.rgroups.length>0)t.rgroups.forEach((e=>{r[e.label]=e.capGroupName}));else{if(!s){if(t.lib)return new Qe(e,i);throw new Error("Unexpected missing monomer without .lib")}r=n.getRS(s)}const o=new et(t.symbol,t.molfile,t.name,t.naturalAnalog,t.polymerType,t.monomerType,r),a=n.getMonomerColors(e,t.symbol);return a&&(o.textcolor=a?.textcolor,o.linecolor=a?.linecolor,o.backgroundcolor=a?.backgroundcolor),o}}const tt={[Me.o.BASE]:{A:"green",G:"black",T:"red",C:"blue",U:"red"},[Me.o.NUCLEOTIDE]:{A:"green",G:"black",T:"red",C:"blue",U:"red"},[Me.o.LINKER]:{P:"#9aa5e1",p:"#9aa5e1"},[Me.o.SUGAR]:{R:"#7a85c1",r:"#7a85c1"},[Me.o.AA]:{A:"rgb(44,160,44)",R:"rgb(23,190,207)",N:"rgb(235,137,70)",D:"rgb(31,119,180)",C:"rgb(188,189,34)",E:"rgb(31, 120, 150)",Q:"rgb(205, 111, 71)",G:"rgb(214,39,40)",H:"rgb(158,218,229)",I:"rgb(23,103,57)",L:"rgb(30,110,96)",K:"rgb(108, 218, 229)",M:"rgb(60,131,95)",F:"rgb(24,110,79)",P:"rgb(255,152,150)",S:"rgb(255,187,120)",T:"rgb(245,167,100)",W:"rgb(182, 223, 138)",Y:"rgb(152,223,138)",V:"rgb(74,160,74)"},[Me.o.CHEM]:{R:"#eeeeee"},[Me.o.BLOB]:{B:"#999999",G:"#e2e2e2"}},nt=/[\w()]+/,rt=RegExp(String.raw`\(${nt}(,${nt})+\)`),it=new ze.Mi([255,255,255]),st=new ze.Mi([0,0,0]),ot=.7*(0,F.wQ)(it);class at{_monomers;_isEmpty;get isEmpty(){return this._isEmpty}_onChanged=new u.Subject;get onChanged(){return this._onChanged}constructor(e){this._monomers=e,this._isEmpty=!this._monomers||0===Object.keys(this._monomers).length||Object.entries(this._monomers).every((([e,t])=>0===Object.keys(t).length))}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t==fe._S||t===fe.b9[fe.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:X().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ot.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}getWebEditorMonomer(e,t){const[n,r]=(0,Ke.fA)(e,t),i=(0,je.Y)(n);let s=this.getMonomer(i,r);if(s&&n==Me.o.LINKER&&2!=s.rgroups.length)return null;if(s&&n==Me.o.SUGAR&&3!=s.rgroups.length)return null;s||(s=this.addMissingMonomer(i,r));let o=s.wem??null;return o||(r===fe._S||"*"==r?o=s.wem=new Ze(n):n===Me.o.NUCLEOTIDE&&"N"===r||n===Me.o.AA&&"X"===r||(Me.o.CHEM,0)||rt.test(r)?o=s.wem=new Xe(n,r):s.lib||(o=s.wem=new Je(n,r,this.isEmpty)),o||(o=s.wem=et.fromMonomer(n,s,this))),o}getTooltip(e,t){const n=(0,je.Y)(e),r=o.div([],{classes:"ui-form ui-tooltip"}),i=this.getMonomer(n,t);if(i){const n=i.symbol,a=(i.name,this.getWebEditorMonomer(e,t));a.backgroundcolor,r.append(o.divH([o.div([n],{style:{textWrap:"nowrap",marginLeft:"4px",marginRight:"4px",color:a.textcolor,backgroundColor:a.backgroundcolor,borderColor:a.linecolor,borderWidth:"1px",borderStyle:"solid",borderRadius:"2px",padding:"3px",minWidth:"24px",textAlign:"center"}}),o.div([i.name],{style:{padding:"4px"}})],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const c={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let l;l=i.molfile?s.chem.svgMol(i.molfile,void 0,void 0,c):i.smiles?o.divV([s.chem.svgMol(i.smiles,void 0,void 0,c),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),r.append(o.div(l,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),i.symbol!=fe._S&&r.append(o.divText(i.lib?.source??"Missed in libraries"))}else r.append(o.divV([o.divText(`Monomer '${t}' of type '${n}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return r}getMonomerTextColor(e,t){const n=this.getMonomerColors(e,t),r=e=>{const t=/rgb\(\s*(\d+)\s*,\s*(\d+)\s*,\s*(\d+)\s*\)/.exec(e);if(t)return[parseInt(t[1]),parseInt(t[2]),parseInt(t[3])];const r=a.Color.fromHtml(n.textcolor);return[a.Color.r(r),a.Color.g(r),a.Color.b(r)]},i=r(n.textcolor),s=new ze.Mi([...i.map((e=>e+1))]),o=(0,F.KE)(s,it)/((0,F.wQ)(s)*(0,F.wQ)(it)),c=r(n.backgroundcolor),l=new ze.Mi([...c.map((e=>e+.01))]);let u;u=(0,F.KE)(l,it)/((0,F.wQ)(l)*(0,F.wQ)(it))<o?c:i;let d=new ze.Mi(u);const h=(0,F.wQ)(d);return h>ot&&(d=(0,F.dC)(st,d,ot/h)),`rgb(${d[0]}, ${d[1]}, ${d[2]})`}getMonomerColors(e,t){const n="default";let r=n;const i=(0,je.Y)(e),s=this.getMonomer(i,t);let o;if(s){if(s.meta&&s.meta.colors){const e=s.meta.colors;n in e||(r="default"),o=e[r]}if(!o){const t=tt[e],n=t?.[s.symbol];n&&(o={textColor:a.Color.toHtml(a.Color.getContrastColor(a.Color.fromHtml(n))),lineColor:"#202020",backgroundColor:n})}const t=s.naturalAnalog;if(!o&&t)return this.getMonomerColors(e,t)}return o||(o={textColor:"#202020",lineColor:"#202020",backgroundColor:"#A0A0A0"}),{textcolor:o.text??o.textColor,linecolor:o.line??o.lineColor,backgroundcolor:o.background??o.backgroundColor}}getRS(e){const t=e.match(/(?<=\[)[^\][]*(?=])/gm),n={};let r,i="";if(t)for(let e=0;e<t.length;e++)if(null!=t[e]&&/\d/.test(t[e])){r=t[e][t[e].length-1],t[e]=t[e].replace(/[0-9]/g,"");for(let n=0;n<t[e].length;n++)":"!=t[e][n]&&(i+=t[e][n]);n["R"+r]=i,i=""}return n}}var ct=n(5488),lt={};lt.styleTagTransform=C(),lt.setAttributes=b(),lt.insert=g().bind(null,"head"),lt.domAPI=m(),lt.insertStyleElement=v(),h()(ct.A,lt),ct.A&&ct.A.locals&&ct.A.locals;class ut extends at{source;error;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){super(e),this.source=t,this.error=n;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?.[n]??null}else{Ot.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=(0,je.Y)(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=We.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))})),this._isEmpty=this.isEmpty&&e.isEmpty}updateLibs(e,t=!1){t&&(this._monomers={},this._isEmpty=!0),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,Ee.ub)().then((e=>{this.assignDuplicatePreferences(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferences(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const i=e.duplicateMonomerPreferences[n][r],s=this.duplicateMonomers[n][r].find((e=>e.lib?.source===i));s?this._monomers[n][r]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of X().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}override(e){return new dt(e,this)}}class dt extends at{data;base;constructor(e,t){super(e),this.data=e,this.base=t}get onChanged(){return this.base.onChanged}addMissingMonomer(e,t){return this.base.addMissingMonomer(e,t)}getMonomer(e,t){const n=this.data[e]?.[t];return n??this.base.getMonomer(e,t)}}class ht{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,i){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=i;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class pt{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var mt=n(7433),ft=n.n(mt),gt=n(1913),yt=n.n(gt);class bt{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(ft())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});yt()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const i of e){const e=i.symbol??i.id??i.name??"#N/A";if(n=this.validateMonomerSchema(i),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,i,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${i.polymerType??""}-${e}`;r.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(s)}return n}}var wt=n(8604);class vt{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++vt.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await s.dapi.files.readAsText(wt.gt),i=JSON.parse(r),o=new bt(i);return new vt(o,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(wt.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(wt.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(wt.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(wt.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(wt.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),i=await r.readAsText(t);n=JSON.parse(i);const s={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(s[t]={},o.push(t)),s[t][n]=e})),new ut(s,t)}async loadSetFromFile(e,t,n){let r={};const i=new a.FileSource(t),s=await i.readAsText(n);r=JSON.parse(s);const o=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,i=n.polymerType,s=n.monomerType,o=n.set;return new ht(e,r,i,s,o)}));return new pt(o,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(wt.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${wt.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ot.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ot.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ot.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(wt.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ot.logger.debug(`${e}, OUT`)})),Ot.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(wt.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(wt.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(wt.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(wt.Es.length)))}}class At{constructor(){}static _instance;static getInstance(){return At._instance||(At._instance=new At),At._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,P.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Ct{logger;_monomerLib=new ut({},"MAIN");_monomerSets=new pt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=5e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Oe.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++Ct.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return Ct.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferences(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await vt.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,Ee.ub)()]),i=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let s=0;const o=i.length,[a]=await Promise.all([Promise.all(i.map((e=>this.readLibrary(wt.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new ut({},e,n)})).finally((()=>{n.update(Math.round(100*++s/o),`Loading monomers ${s}/${o}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let r=0;const i=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(wt.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new pt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/i),`Loading monomers ${r}/${i}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Ee.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,Ee.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}async loadMonomerLibForTests(){await(0,Ee.Eu)(wt.G3),await this.awaitLoaded(),await this.loadMonomerLib(!0)}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new Ct(Ot.logger);return e._eventManager=At.getInstance(),e})()),e}}n(1757);var Et=n(3017),Tt={};Tt.styleTagTransform=C(),Tt.setAttributes=b(),Tt.insert=g().bind(null,"head"),Tt.domAPI=m(),Tt.insertStyleElement=v(),h()(Et.A,Tt),Et.A&&Et.A.locals&&Et.A.locals,n(3151);new O.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),new O.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),new O.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048);new O.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),new O.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),new O.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048);var St,_t=n(857),xt={};xt.styleTagTransform=C(),xt.setAttributes=b(),xt.insert=g().bind(null,"head"),xt.domAPI=m(),xt.insertStyleElement=v(),h()(_t.A,xt),_t.A&&_t.A.locals&&_t.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(St||(St={})),St.MONOMER,a.COLUMN_TYPE.STRING,St.SYMBOL,a.COLUMN_TYPE.STRING,St.NAME,a.COLUMN_TYPE.STRING,St.R_GROUPS,a.COLUMN_TYPE.STRING,St.MONOMER_TYPE,a.COLUMN_TYPE.STRING,St.POLYMER_TYPE,a.COLUMN_TYPE.STRING,St.NATURAL_ANALOG,a.COLUMN_TYPE.STRING,St.AUTHOR,a.COLUMN_TYPE.STRING,St.CREATE_DATE,a.COLUMN_TYPE.DATE_TIME,St.ID,a.COLUMN_TYPE.INT,St.META,a.COLUMN_TYPE.STRING,St.SOURCE,a.COLUMN_TYPE.STRING;var Mt,Pt=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};class Lt{constructor(e,t,n=!1,r){var i;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>Pt(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>Pt(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>Pt(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(i=null==r?void 0:r.autoStartFirstStep)&&void 0!==i&&i,this._progress.max=0,this._progress.value=1,Lt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas 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r=s.shell.isInDemo?Array.from(s.shell.view("Browse").dockManager.rootNode.children)[0]:Array.from(s.shell.dockManager.rootNode.children)[0];this._node=s.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r,""),(null===(t=null===(e=r.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=r.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return Pt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const 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t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class ${static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}$.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class I{constructor(e="categorial"){this.aa2num=$.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const r=["NH2","COOH"];if(e.startsWith(r[0])){const n=r[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${r[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(r[1])){const t=r[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${r[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return I._dropDefises(I._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let r=0;r<t;++r){const t=e[r];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[r]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const r=e[n];(0,N.vA)(r in this.num2aa,`Unknown code '${r}' found in vector '${e}'`),t+=this.num2aa[r]}return t}}var R=n(4139);const O="input.fa",k="result.fasta";class D extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function G(e){return 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isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>S,AR:()=>T});var r=n(7389),i=n(6082),s=n(4328),o=n(1991),a=n.n(o),c=n(1858),l=n(2003),u=n(8070),d=n(826),h=n(7602),p=n(8115),m=n(4577),f=n(1757),g=n.n(f),y=n(9124),b=n(9192),w=n(4870),v=n(3572);class A extends m.O{emptyProps=new m.n("");helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++A.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,y.b2)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await 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0,n)}})))}catch(e){const[t,n]=(0,b.AP)(e),i=this._filterPanel;i.innerText="error",i.classList.add("d4-error"),r.tooltip.bind(i,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,w.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,w.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}const C="bio-substructure-filter";class E{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,i){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=i}}class T extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class S extends i.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++S.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(i.SEMTYPE.MACROMOLECULE)),d.G.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new _:this.notation===l.Hi.SEPARATOR?new x(this.column.getTag(l.gp.separator)):new A,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(i.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=i.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(C,new E(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class x extends m.O{emptyProps=new T("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new T(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("")}get filterPanel(){return 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0)}},fastaMsaExtManyMinus:{csv:"seq\n[D-Tic]-------[D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]N[D-Orn][D-aThr]-[Phe_4Me]\n[Phe_2F]--------[Tyr_ab-dehydroMe][dV][Aca]N[D-Orn][D-aThr]-[Phe_4Me]\n[D-Tic]-[Hcy]QTWQ[Phe_4NH2][D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]----[Phe_4Me]",pos:{seq:new u(c.Hi.FASTA,"SEQ.MSA",c.YI.UN,17,!0,void 0)}},sepSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-C-G-NH2",pos:{seq:new u(c.Hi.SEPARATOR,"SEQ.MSA",c.YI.UN,5,!0,"-")}},sepMsaSameLength:{csv:"seq\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2\nAca-A-Aca-A-A-A-meI-A-A-A-A-A-Aca-G-NH2\nAca-A-A-A-A-A-A-A-A-A-A-A-A-A-Aca-G-NH2",pos:{seq:new u(c.Hi.SEPARATOR,"SEQ",c.YI.UN,5,!0,"-")}},helmSameLength:{csv:"seq\nPEPTIDE1{Ac(1).A.A.A.A.A.A.A.A.A.A.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ab(1).Y.V.K.H.P.F.W.R.W.Y.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ad(1).S.W.Y.C.K.H.P.M.W.A.A.A.A.C(1)-G-NH2}$$$$",pos:{seq:new u(c.Hi.HELM,null,null,19,void 0,void 0)}},fastaNonDigitAlphabet:{csv:'flagC\n"NMe-pyridazineH"\n"Pyrrolo[2,3-c]pyridazineH"',neg:["flagC"]}};for(const[r,i]of Object.entries(n))(0,t.t6)(`csvData2-${r}`,(async()=>{const t=(s=r,async()=>{const t=n[s].csv,r=e.DataFrame.fromCsv(t);return await a.data.detectSemanticTypes(r),r});var s;for(const e of i.neg??[])await d(t,e);for(const[e,n]of Object.entries(i.pos??{}))await h(t,e,n.units,n.aligned,n.alphabet,n.alphabetSize,n.alphabetIsMultichar,n.separator)}));const r=new class{csvFastaDna1="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC";fastaRna1="seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC";fastaPt1="seq\nFWPHEY\nYNRQWYV\nMKPSEYV";fastaUn="seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]DN\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]";sepDna="seq\nA*C*G*T*C*A*C*G*T*C\nC*A*G*T*G*T*C*A*G*T*G*T\nT*T*C*A*A*C*T*T*C*A*A*C";sepRna="seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C";sepPt="seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V";sepUn1="seq\nabc-dfgg-abc1-cfr3-rty-wert-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-cfr3-wert-rut12";sepUn2="seq\nabc/dfgg/abc1/cfr3/rty/wert/abc/dfgg/abc1/cfr3/rty/wert\nrut12/her2/rty/wert//abc/abc1/dfgg/rut12/her2/rty/wert//abc/abc1/dfgg\nrut12/rty/her2/abc/cfr3//wert/rut12/rut12/rty/her2/abc/cfr3//wert/rut12";sepMsaDna1="seq\nA-C--G-T--C-T-A-C--G-T--C-T\nC-A-C--T--G-T-C-A-C--T--G-T\nA-C-C-G-T-A-C-T-A-C-C-G-T-A-C-T";sepMsaUnWEmpty="seq\nm1-M-m3-mon4-mon5-N-T-MON8-N9-m1-M-m3-mon4-mon5-N-T-MON8-N9\nm1-mon2-m3-mon4-mon5-Num--MON8-N9-m1-mon2-m3-mon4-mon5-Num--MON8-N9\n\nmon1-M-mon3-mon4-mon5---MON8-N9-mon1-M-mon3-mon4-mon5---MON8-N9";sepComplex="seq\nAca-F-K(AEEA-AEEA-R-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-ARRA-W-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2\nAca-F-K(AEEA-AEEA-Ac)-L-mF-V-Y-mNle-D-W-N-mF-Aca-G-NH2";fastaMsaDna1="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT";fastaMsaPt1="seq\nFWR-WYV-KHPFWR-WYV-KHP\nYNR-WYV-KHPYNR-WYV-KHP\nMWRSWY-CKHPMWRSWY-CKHP"},i={fastaPtCsv:"System:AppData/Bio/samples/FASTA_PT.csv",msaComplex:"System:AppData/Bio/samples/MSA.csv",fastaCsv:"System:AppData/Bio/samples/FASTA.csv",helmCsv:"System:AppData/Bio/samples/HELM.csv",peptidesComplex:"System:AppData/Bio/tests/peptides_complex_msa.csv",peptidesSimple:"System:AppData/Bio/tests/peptides_simple_msa.csv",testDemogCsv:"System:AppData/Bio/tests/testDemog.csv",testHelmCsv:"System:AppData/Bio/tests/testHelm.csv",testIdCsv:"System:AppData/Bio/tests/testId.csv",testSmilesCsv:"System:AppData/Bio/tests/testSmiles.csv",testSmiles2Csv:"System:AppData/Bio/tests/testSmiles2.csv",testSmilesShort:"System:AppData/Bio/tests/testSmilesShort.csv",testActivityCliffsCsv:"System:AppData/Bio/tests/testActivityCliffs.csv",testCerealCsv:"System:AppData/Bio/tests/testCereal.csv",testUnichemSources:"System:AppData/Bio/tests/testUnichemSources.csv",testDmvOffices:"System:AppData/Bio/tests/testDmvOffices.csv",testAlertCollection:"System:AppData/Bio/tests/testAlertCollection.csv",testSpgi100:"System:AppData/Bio/tests/testSpgi100.csv",testSpgi:"System:AppData/Bio/tests/SPGI-derived.csv",testUrl:"System:AppData/Bio/tests/testUrl.csv"},s={};function 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e.loadMonomerLibForTests(),function(e,n){const r=n,i=e.getSummaryObj();for(const e in r)r[e]||delete r[e];for(const e in i)i[e]||delete i[e];if(0==Object.keys(r).length&&0!=Object.keys(i).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(r).length&&0==Object.keys(i).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(i,r),(0,t.Xk)(r,i)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(r)} does not match actual ${JSON.stringify(i)}.`)}}(e.getMonomerLib(),R.VV)})),(0,t.t6)("empty",(async()=>{const n=await(0,N.ub)(),r=await e.getFileManager();let i=r.getValidLibraryPaths();0===i.length&&(i=await r.getValidLibraryPathsAsynchronously()),n.exclude=i,n.explicit=[],await(0,N.Eu)(n),await e.loadMonomerLib(!0);const s=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===s.length,!0)})),(0,t.t6)("override",(async()=>{const n={symbol:"over1",name:"Test override monomer 1",molfile:"",author:"Test 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n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=L.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,L.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),r=(0,p.importFasta)(n)[0],i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),console.log("Bio: tests/renderers/afterMsa, table view"),await 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a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const u=await(0,F.r)(i,c.Hi.SEPARATOR,"/");await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const d=u.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),l.G.forColumn(u)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const n=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),r=a.shell.addTableView(n);await P(r.grid);const i=n.getCol("sequence"),s=l.G.forColumn(i).convert(c.Hi.HELM);n.columns.add(s),await P(r.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=c.Hi.SEPARATOR,n.setTag(c.gp.separator,"/"),n.setTag(c.gp.aligned,"SEQ"),n.setTag(c.gp.alphabet,"UN"),n.setTag(c.gp.alphabetIsMultichar,"true"),n.semType=L.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const i=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==i)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${i}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const r=e.DataFrame.fromCsv(n);r.currentRowIdx=0;const i=a.shell.addTableView(r),s=r.plot.scatter({x:"x",y:"y"});i.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),P(i.grid,500)]);const o=s.root.getBoundingClientRect(),c=s.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:o.left+c.x,clientY:o.top+c.y}),u=D()(s.root).find("canvas").get()[0];await(0,t.PE)((0,G.fromEvent)(u,"mousemove"),(()=>{Se.logger.debug(`Test: event, currentRowIdx=${r.currentRowIdx}`),(0,t.E3)(D()(O.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await P(i.grid,500)}()}));const n="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var V=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,S.pj)(),r=await(0,N.ub)(),await n.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(r),await n.loadMonomerLib(!0)}));const i={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(i))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),i=new V.Jy(null,n,Se.logger,3,(()=>({seqHandler:l.G.forColumn(n),monomerCharWidth:7,separatorWidth:12,monomerToShort:c.zS}))),s=r.testList;for(let e=0;e<n.length;++e)i.getCellMonomerLengths(e,1e4);const o=[];for(const[e,t]of E().enumerate(s)){const t={pos:i.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", \n"))}))})),(0,t.L1)("renderers: monomerPlacer",(()=>{const e=[10,20,30,40,50,60],n={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[r,i]of Object.entries(n))(0,t.t6)("hitBounds-"+r,(async()=>{const n=(0,V.Bb)(e,i.x);(0,t.E3)(n,i.tgt)}))})),(0,t.L1)("converters",(()=>{let n;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(n||(n={}));const r={[n.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[n.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[n.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[n.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[n.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[n.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[n.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[n.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[n.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[n.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[n.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[n.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[n.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[n.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[n.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[n.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[n.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[n.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},i=new Set(Object.values(c.gp));async function s(t){const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i}function o(e,n){if(e===c.Hi.SEPARATOR&&!n)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(r){const i=l.G.forColumn(r).convert(e,n);return(0,t.E3)(i.meta.units,e),i}}async function u(e,n,r){const o=(await s(e)).getCol("seq"),a=n(o),u=(await s(r)).getCol("seq");(0,t.J6)(a.toList(),u.toList());const d=l.G.forColumn(o),h=l.G.forColumn(a);for(const[e,n]of Object.entries(u.tags)){if(!i.has(e)||d.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e)||h.notation===c.Hi.HELM&&[c.gp.alphabet,c.gp.alphabetIsMultichar].includes(e))continue;const r=a.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await u(n.fastaPt,o(c.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testFastaDnaToSeparator",(async()=>{await u(n.fastaDna,o(c.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testFastaRnaToSeparator",(async()=>{await u(n.fastaRna,o(c.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testFastaGapsToSeparator",(async()=>{await u(n.fastaGaps,o(c.Hi.SEPARATOR,"/"),n.separatorGaps)})),(0,t.t6)("testFastaUnToSeparator",(async()=>{await u(n.fastaUn,o(c.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testFastaPtToHelm",(async()=>{await u(n.fastaPt,o(c.Hi.HELM),n.helmPt)})),(0,t.t6)("testFastaDnaToHelm",(async()=>{await u(n.fastaDna,o(c.Hi.HELM),n.helmDna)})),(0,t.t6)("testFastaRnaToHelm",(async()=>{await u(n.fastaRna,o(c.Hi.HELM),n.helmRna)})),(0,t.t6)("testFastaGapsToHelm",(async()=>{await u(n.fastaGaps,o(c.Hi.HELM),n.helmGaps)})),(0,t.t6)("testSeparatorPtToFasta",(async()=>{await u(n.separatorPt,o(c.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testSeparatorDnaToFasta",(async()=>{await u(n.separatorDna,o(c.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testSeparatorRnaToFasta",(async()=>{await u(n.separatorRna,o(c.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testSeparatorGapsToFasta",(async()=>{await u(n.separatorGaps,o(c.Hi.FASTA),n.fastaGaps)})),(0,t.t6)("testSeparatorUnToFasta",(async()=>{await u(n.separatorUn,o(c.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testSeparatorPtToHelm",(async()=>{await u(n.separatorPt,o(c.Hi.HELM),n.helmPt)})),(0,t.t6)("testSeparatorDnaToHelm",(async()=>{await u(n.separatorDna,o(c.Hi.HELM),n.helmDna)})),(0,t.t6)("testSeparatorRnaToHelm",(async()=>{await u(n.separatorRna,o(c.Hi.HELM),n.helmRna)})),(0,t.t6)("testSeparatorGapsToHelm",(async()=>{await u(n.separatorGaps,o(c.Hi.HELM),n.helmGaps)})),(0,t.t6)("testHelmDnaToFasta",(async()=>{await u(n.helmDna,o(c.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testHelmRnaToFasta",(async()=>{await u(n.helmRna,o(c.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmPtToFasta",(async()=>{await u(n.helmPt,o(c.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testHelmUnToFasta",(async()=>{await u(n.helmUn,o(c.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testHelmDnaToSeparator",(async()=>{await u(n.helmDna,o(c.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmRnaToSeparator",(async()=>{await u(n.helmRna,o(c.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testHelmPtToSeparator",(async()=>{await u(n.helmPt,o(c.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testHelmUnToSeparator",(async()=>{await u(n.helmUn,o(c.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testHelmLoneRibose",(async()=>{await u(n.helmLoneRibose,o(c.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmLoneDeoxyribose",(async()=>{await u(n.helmLoneDeoxyribose,o(c.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmLonePhosphorus",(async()=>{await u(n.helmLonePhosphorus,o(c.Hi.FASTA),n.fastaRna)}))}));var B=n(3516);(0,t.L1)("fastaFileHandler",(()=>{const n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function i(e){const i=new B.m(e),s=i.descriptionsArray,o=i.sequencesArray;(0,t.J6)([s,o],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{i(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{i(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n ")})),(0,t.t6)("testExtraNewlines",(async()=>{i(">description:1\n\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVF\nLFGIVLGLI\nPITLAGLFVTA\nYLQYRRGDQLDL\n\n>description:3\nM\nME\n\nLVLKTIIG\n\nPIVVGVVLRI\nVDKWLNKDK\n\n\n>description:4\n\nMDRT\n\nDEVSNHTHDKP\n\nTLTWFEEIFEE\n\n\n\nYHSPFHN\n")}))}));var Y=n(3890);(0,t.L1)("fastaExport",(()=>{let n;!function(e){e.single="single",e.multi="multi"}(n||(n={}));const r={[n.single]:{src:"MDYKETLLMPKTDFPMRGGLP",tgt:["MDYKETLLMP","KTDFPMRGGL","P"]},[n.multi]:{src:"M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",tgt:["M[MeI]YKETLL[MeF]P","KTDFPMRGGL","[MeA]"]}};let i;!function(e){e.test1="test1",e.test2="test2"}(i||(i={}));const 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s=i.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const o=await i.dataFrame.plot.fromType("Sequence Diversity Search");let c=!1;if(o.computeCompleted.subscribe((e=>{e&&(c=!0)})),i.dockManager.dock(o,e.DOCK_TYPE.DOWN,null,"Diversity"),await o.renderPromise,await(0,t.bk)((()=>void 0!==J(i,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!o.initialized)throw new Error("The viewer is not initialized.");if(!o.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!o.beforeRender())throw new Error("The viewer is not able to render.");if(!o.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=o;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been 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Available in data frame are ${JSON.stringify(t.columns.names())}`);const n=new ee._i;return n.attach(t),n.applyState({columnName:e}),n.column=t.col(e),n.columnName=e,n}(0,t.L1)("bio-substructure-filters",(async()=>{let n,r,i;(0,t.gM)((async()=>{n=await(0,Q.b2)(),r=await(0,S.pj)(),i=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("fasta",(async()=>{const e=await M("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=new ee._i;n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new te.n("MD")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,3),(0,t.E3)(n.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("separator",(async()=>{const e=await M("tests/filter_MSA.csv"),n=new ee._i;await a.data.detectSemanticTypes(e),n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"SeparatorBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("/meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI-hHis","-")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1)}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("helm-dialog",(async()=>{const e="Bio tests: substructureFilters/helm-dialog",n=await M("tests/filter_HELM.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n);Se.logger.debug(`${e}, filter attaching.`);const i=new ee._i;i.attach(n);const s=O.dialog("Test filters").add(i.root).show();await i.awaitRendered();try{const s=i.bioFilter;(0,t.E3)(null!==i.bioFilter,!0,"bioFilter is not created"),Se.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{A.C}$$$$V2.0")}),2e4),Se.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,1),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"0001"),Se.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{C}$$$$V2.0")}),2e4),await P(r.grid),Se.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,2),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"1001")}finally{s.close()}await i.awaitRendered(),await(0,t.cb)(3e3)})),(0,t.t6)("helm-view",(async()=>{const e=await M("tests/filter_HELM.csv");e.getCol("HELM string"),await a.data.detectSemanticTypes(e);const t=a.shell.addTableView(e);t.getFiltersGroup(),await P(t.grid)})),(0,t.t6)("sync-fasta",(async()=>{const e=await Se.files.readCsv("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=await ne("fasta",e),r=await ne("fasta",e);await Promise.all([n.awaitRendered(),r.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const i=n.bioFilter,s=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{i.props=new te.n("MD")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(s.props.substructure,"MD")}finally{n.detach(),r.detach()}await Promise.all([n.awaitRendered(),r.awaitRendered()])})),(0,t.t6)("sync-msa",(async()=>{const e=await Se.files.readCsv("tests/filter_MSA.csv");await a.data.detectSemanticTypes(e);const n="hHis-Aca",r=await ne("MSA",e),i=await ne("MSA",e);await Promise.all([r.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter");const s=r.bioFilter,o=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{s.props=new ee.AR(n,"-")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(o.props.substructure,n),(0,t.E3)(o.props.separator,"-")}finally{r.detach(),i.detach()}await Promise.all([r.awaitRendered(),i.awaitRendered()])})),(0,t.t6)("sync-helm",(async()=>{const e=await Se.files.readCsv("tests/filter_HELM.csv");await a.data.detectSemanticTypes(e);const n=a.shell.addTableView(e),r="PEPTIDE1{A.C}$$$$V2.0",i=await ne("HELM string",e),s=await ne("HELM string",e),o=O.dialog("Test filters").add(i.root).add(s.root).show();await Promise.all([i.awaitRendered(),s.awaitRendered()]);try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"HelmBioFilter"),(0,t.E3)(s.bioFilter.type,"HelmBioFilter");const o=i.bioFilter,a=s.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(r)}),6e4,"await onRowsFiltered"),await P(n.grid),Se.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*i.debounceTime),Se.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,1),await i.awaitRendered(),(0,t.E3)(a.props.substructure,r)}finally{i.detach(),s.detach(),o.close()}await Promise.all([i.awaitRendered(),s.awaitRendered()]),await P(n.grid),await(0,t.cb)(3e3)})),(0,t.t6)("two-columns-fasta",(async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="seq1",s="CGGCTG",o=n.getCol("trueSeq1").toList(),c="seq2",l="GCATT",u=n.getCol("trueSeq2").toList(),d=[{type:"Bio:bioSubstructureFilter",columnName:i},{type:"Bio:bioSubstructureFilter",columnName:c}],h=await n.plot.fromType(e.VIEWER.FILTERS,{filters:d});r.dockManager.dock(h,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid);const p=h.filters[0],m=h.filters[1];(0,t.E3)(p.column.name,i),(0,t.E3)(m.column.name,c);const f=p.bioFilter,g=m.bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n(s)}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n("")}),1e3,"testEvent onRowsFiltered on 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y=E().count(0).take(n.rowCount).map((e=>o[e]*u[e])).toArray();(0,t.E3)(n.filter.trueCount,y.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),y.map((e=>e.toString())).join("")),await Promise.all([p.awaitRendered(),m.awaitRendered(),P(r.grid)])})),(0,t.t6)("reset-fasta",(async()=>{const n=await M("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="MD",s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});r.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid);const o=s.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(i)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(o.props.substructure,i),(0,t.E3)(o.substructureInput.value,i),D()(s.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await 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n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,re.GD)(n.getCol("HELM"),"msa(HELM)"),i=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==i.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new ie,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),i=await(0,re.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),s=r.getCol("MSA");(0,t.J6)(i.toList(),s.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")}),{timeout:6e4,stressTest:!0}),(0,t.t6)("error",(async()=>{const n=new ie;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,re.GD)(t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,r]=(0,se.AP)(e);n.error(t,void 0,r)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")}))})),(0,t.L1)("viewers",(()=>{const n=e.Func.find({package:"Bio",tags:["viewer"]}).map((e=>e.friendlyName));for(const e of n)(0,t.t6)(e,(async()=>{const n=await M("samples/FASTA_DNA.csv");await(0,t.Bl)(e,n,{detectSemanticTypes:!0})}),{skipReason:{"Sequence Similarity Search":"GROK-13162","Sequence Diversity Search":"GROK-13162",WebLogo:"GROK-13162",VdRegions:"GROK-13162"}[e]})}));const oe="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",ae="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",ce="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var le;(0,t.L1)("SeqHandler",(()=>{async function n(t){const n=e.DataFrame.fromCsv(t);await a.data.detectSemanticTypes(n);const r=l.G.forColumn(n.getCol("seq"));return[n,r]}(0,t.t6)("Seq-Fasta",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,c.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA",(async()=>{const[e,r]=await n(ae);(0,t.E3)(r.notation,c.Hi.FASTA),(0,t.E3)(r.isMsa(),!0)})),(0,t.t6)("Seq-Fasta-units",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,c.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA-units",(async()=>{const[e,r]=await 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p={[d.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[d.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[d.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[d.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[d.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[d.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[d.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[d.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[d.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async 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n=t.src.seq,r=e.DataFrame.fromColumns([e.Column.fromList(e.COLUMN_TYPE.STRING,"seq",[n])]);return await a.data.detectSemanticTypes(r),r.getCol("seq")};for(const[e,n]of Object.entries(o))(0,t.t6)(`${e}-linear`,(async()=>{const e=await l(n);await u(e,!1,n.tgt)}));for(const[e,n]of Object.entries(o))(0,t.t6)(`${e}-nonlinear`,(async()=>{const e=await l(n);await u(e,!0,n.tgt)}));async function u(n,r,o){const a=await(0,ge.V)(n.dataFrame,n,r,!1,i,s);(0,t.E3)(a.molCol.semType,e.SEMTYPE.MOLECULE);const c=a.molCol.get(0),l=s.get_mol(c);(0,t.E3)(null!=l,!0,"No molecule generated");try{const e=l.get_num_atoms(),n=l.get_num_bonds();(0,t.E3)(e,o.atomCount),(0,t.E3)(n,o.bondCount)}finally{l.delete()}}}));var ye=n(6863);async function be(t){const n=e.DataFrame.fromCsv(t),r=n.col("seq"),i=await a.functions.call("Bio:detectMacromolecule",{col:r});return i&&(r.semType=i),await a.data.detectSemanticTypes(n),l.G.forColumn(r)}function we(e,n,r,i){const s=r(e,n);(0,t.E3)(Number(s.toFixed(3)),Number(i.toFixed(3)))}(0,t.L1)("Distance",(async()=>{const n=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],r={F:0,W:1,R:2,Y:3},i="FWRWY",s="FWRWW",o="FWY",a="FWRWY",c="FWY",l="FWRRRRY";(0,t.t6)("protein-distance-function",(async()=>{const e=(await be("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP")).getDistanceFunctionName();(0,t.E3)(e,ye.Z.LEVENSHTEIN)})),(0,t.t6)("DNA-distance-function",(async()=>{const e=(await be("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,ye.Z.LEVENSHTEIN)})),(0,t.t6)("MSA-distance-function",(async()=>{const e=(await be("seq\nATAACATAAC\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,ye.Z.HAMMING)})),(0,t.t6)("levenstein-sub",(async()=>{const e=ye.V[ye.Z.LEVENSHTEIN]();we(i,s,e,.2)})),(0,t.t6)("levenstein-del",(async()=>{const e=ye.V[ye.Z.LEVENSHTEIN]();we(o,a,e,.4)})),(0,t.t6)("hamming",(async()=>{const e=ye.V[ye.Z.HAMMING]();we(o,a,e,.6)})),(0,t.t6)("needleman-blosum62",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});we(i,s,e,-6)})),(0,t.t6)("needleman-blosum62-del",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});we(o,a,e,-3.667)})),(0,t.t6)("needleman-custom-sub",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});we(i,s,e,.2)})),(0,t.t6)("needleman-custom-del",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});we(o,a,e,.667)})),(0,t.t6)("needleman-custom-zero-extend",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:0});we(c,l,e,.333)})),(0,t.t6)("needleman-custom-half-extend",(async()=>{const e=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:2,gapExtend:1});we(c,l,e,1.667)})),(0,t.t6)("needleman-custom-same-extend",(async()=>{const t=ye.V[ye.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?we(Array(1e3).fill(c).join(""),Array(1e3).fill(l).join(""),t,1.333):we(c,l,t,1.333)}),{benchmark:!0})}));var ve=n(684);async function Ae(e,n,r,i,s,o,c,l){await a.data.detectSemanticTypes(e);const u=await(0,p.activityCliffs)(e,e.getCol(r),e.getCol(i),s,n,c,l,{[`${ve.vb}`]:!0});(0,t.E3)(null!=u,!0);const d=Array.from(u.root.children).find((e=>{const t=e.className.split(" ");return["ui-btn","ui-btn-ok"].every((e=>t.includes(e)))}));(0,t.E3)(d.innerText.toLowerCase(),`${o} cliffs`)}var Ce=n(2780),Ee=n(9039);async function Te(n,r,i){const s=n.getCol(i),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const c=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!c)throw new Error("Preprocessing function not found");const l=await(0,p.sequenceSpaceTopMenu)(n,n.col(i),r,ye.Z.LEVENSHTEIN,!0,c,{[ve.vb]:!0});(0,t.E3)(null!=l,!0)}(0,t.L1)("activityCliffs",(async()=>{let n,r,i;const s=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],o=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)((async()=>{n=await(0,Q.b2)(),r=await(0,S.pj)(),i=await(0,N.ub)(),await r.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("activityCliffsOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv",tgt:{cliffCount:53}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await M(t.fileName);a.shell.addTableView(n),await Ae(n,Ee.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,ye.Z.LEVENSHTEIN,s)}),{benchmark:!0}),(0,t.t6)("activityCliffsWithEmptyRows",(async()=>{const e=await M("tests/100_3_clustests_empty_vals.csv");a.shell.addTableView(e),await Ae(e,Ee.c.UMAP,"sequence","Activity",90,3,ye.Z.LEVENSHTEIN,s)})),(0,t.t6)("Helm",(async()=>{const e=await Se.files.readCsv("samples/HELM_50.csv");a.shell.addTableView(e),await Ae(e,Ee.c.UMAP,"HELM","Activity",65,20,Ce.aT.Tanimoto,o)}))})),(0,t.L1)("sequenceSpace",(async()=>{let n,r,i,s;(0,t.t6)("sequenceSpaceOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await M(t.fileName),r=a.shell.addTableView(n),await Te(n,Ee.c.UMAP,"sequence")}),{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",(async()=>{i=await M("tests/100_3_clustests_empty_vals.csv"),s=a.shell.addTableView(i),await Te(i,Ee.c.UMAP,"sequence")}))})),(0,t.L1)("Scoring",(()=>{const n="sequence",r="expected_similarity",i="expected_identity",s=e.DataFrame.fromCsv(`${n},${r},${i}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.68,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.34,0.0`),o=s.getCol(n);o.meta.units=c.Hi.HELM,o.semType=e.SEMTYPE.MACROMOLECULE;const a=o.get(0);let l,u;(0,t.gM)((async()=>{l=await(0,p.getMonomerLibHelper)(),u=await(0,N.ub)(),await l.loadMonomerLibForTests()})),(0,t.Pl)((async()=>{await(0,N.Eu)(u),await l.loadMonomerLib(!0)})),(0,t.t6)("Identity",(async()=>{const e=await(0,p.sequenceIdentityScoring)(s,o,a);for(let n=0;n<e.length;n++){const r=e.get(n),o=s.get(i,n);(0,t.Wj)(r,o,.01,`Wrong identity score for sequence at position ${n}`)}})),(0,t.t6)("Identity-shortReference",(async()=>{const e=await(0,p.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$");(0,t.E3)(E().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Identity-longReference",(async()=>{const e=await(0,p.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$");(0,t.E3)(E().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Similarity",(async()=>{const e=await(0,p.sequenceSimilarityScoring)(s,o,a);for(let n=0;n<e.length;n++){const i=e.get(n),o=s.get(r,n);(0,t.Wj)(i,o,.01,`Wrong similarity score for sequence at position ${n}`)}}))}));const Se=new e.Package;async function _e(n,r,i,s){const o=await(0,t.N$)({category:n,test:r,testContext:i,stressTest:s});return e.DataFrame.fromObjects(o)}async function xe(){await(0,t.Xb)(Se,Se.getModule("package-test.js"))}})(),bio_test=r})();
8
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