@datagrok/bio 2.15.1 → 2.15.2

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (11) hide show
  1. package/CHANGELOG.md +4 -0
  2. package/dist/731.js +1 -1
  3. package/dist/731.js.map +1 -1
  4. package/dist/package-test.js +3 -3
  5. package/dist/package-test.js.map +1 -1
  6. package/dist/package.js +2 -2
  7. package/dist/package.js.map +1 -1
  8. package/package.json +7 -7
  9. package/src/tests/pepsea-tests.ts +1 -1
  10. package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +8 -1
  11. package/src/utils/pepsea.ts +2 -1
package/dist/package-test.js CHANGED
@@ -1,8 +1,8 @@
1
- var bio_test;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>i});var r=n(7362);class i extends r.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in i.aaSynonyms?i.aaSynonyms[e]:e;return super.get(t)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class s{static getPalette(e="grok"){switch(e){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",r="";for(const i of e)"("==i?t++:")"==i?t--:t?n+=i:r+=i;return isNaN(parseInt(n))?[r,n]:[r,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[r,i]=this.getInnerOuter(e);if(r=r.length>6?`${r.slice(0,3)}...`:r,i=i.length>6?`${i.slice(0,3)}...`:i,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,i,1]:[this.undefinedColor,r,i,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,i,2]:[this.undefinedColor,r,i,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,i,3]:[this.undefinedColor,r,i,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,i,4]:[this.undefinedColor,r,i,4]}return[this.undefinedColor,r,i,0]}}s.SemType="Aminoacids",s.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",s.undefinedColor="rgb(100,100,100)",s.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},s.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},s.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},s.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>i});var r=n(6082);async function i(){const e=r.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},9124:(e,t,n)=>{"use strict";n.d(t,{b:()=>s});var r=n(7389),i=n(6082);async function s(){const e="Helm",t=i.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}i.JsInputBase,r.input.helmAsync=async function(e,t){return(await s()).createHelmInput(e,t)}},4356:(e,t,n)=>{"use strict";n.d(t,{Es:()=>a,Eu:()=>u,so:()=>s,ub:()=>l,yZ:()=>d});var r=n(4328);const i="Libraries",s="System:AppData/Bio/monomer-libraries/",o={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}},a="System:AppData/Bio/monomer-sets/";let c=Promise.resolve();async function l(){let e;return c=c.then((async()=>{const t=await r.dapi.userDataStorage.getValue(i,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await c,e}async function u(e){c=c.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await r.dapi.userDataStorage.postValue(i,"Settings",JSON.stringify(e),!0)})),await c}async function d(){await u(o)}},6718:(e,t,n)=>{"use strict";n.d(t,{A7:()=>d,pj:()=>c,uL:()=>l});var r=n(6082),i=n(4328),s=n(6295),o=(n(3151),n(2738)),a=(n(826),n(3077));async function c(){const e=r.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function l(e,t){e instanceof r.Column&&(e=(0,a.R)(e).columns.toList());const n=(await c()).getMonomerLib(),s=new Array(e.length),l=e[0].length,u=new Float32Array(l);for(let a=0;a<e.length;++a){const c=a<t.length?t.getCanonical(a):o._S,d=n.getMonomer("PEPTIDE",c)?.smiles??"",h=e[a],p=h.getRawData(),m=h.categories,f=m.indexOf("");if(s[a]={categories:m,data:p,emptyIndex:f},void 0===c)continue;const g=r.Column.fromStrings("smiles",m.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(r.DataFrame.fromColumns([g]),await i.chem.getSimilarities(g,d)),w=y?y.getRawData():null;for(let e=0;e<l;++e){const t=p[e];c!==o._S&&t!==f?u[e]+=w[t]:c===o._S&&t===f&&(u[e]+=1)}}for(let n=0;n<u.length;++n){let i=u[n]/t.length;for(let o=0;o<e.length;++o){const e=s[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=r.FLOAT_NULL;break}}u[n]=i}return r.Column.fromFloat32Array("Similarity",u)}async function u(e){const t=(await c()).getMonomerLib(),n=[],s={},o=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=r.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){s[e[t]]=t;const r=o[t],c=""===r?new Array(o.length).fill(0):(await i.chem.getSimilarities(a,r)).getRawData();c[t]=1,n[t]=Array.from(c)}return{scoringMatrix:n,alphabetIndexes:s}}async function d(e,t="Morgan"){const n=(await c()).getMonomerLib(),i=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),o={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||"")),l=r.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await u(e);const d=r.Column.fromStrings("smiles",a),h=(r.DataFrame.fromColumns([d]),(await l.apply({col:d,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await u(e);for(let t=0;t<h.length;++t)if(i[t][t]=1,o[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(i[t][e]=i[e][t]=(0,s.$1)(h[t],h[e]));return{scoringMatrix:i,alphabetIndexes:o}}},7384:(e,t,n)=>{"use strict";n.d(t,{C4:()=>h});var r=n(4328),i=n(6082),s=n(1991),o=n.n(s),a=n(439),c=n(826);const l={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(3151);function d(e){return Math.round(l.PRECISION_FACTOR*e)/l.PRECISION_FACTOR}async function h(e,t,s){if(0===i.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==i.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${i.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let d=t;const h=c.GO.forColumn(t);h.isHelm()&&(d=h.convert(a.Hi.SEPARATOR,"."),d.name=t.name);const m=c.GO.forColumn(d).alphabet;let f;if(m===a.YI.PT||m===a.YI.UN)f="PEPTIDE";else{if(m!==a.YI.RNA&&m!==a.YI.DNA)return{col:null,warnings:[`Unexpected column's '${d.name}' alphabet '${m}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),i=c.GO.forColumn(e);let s=!1;for(let e=0;e<t;++e){const t=i.getSplitted(e);s||(s=0===t.length),n[e]=o()(t.canonicals).filter((e=>!i.isGap(e))).map((e=>e)).toArray()}return s&&r.shell.warning(`Some values in the "${e.name}" column are empty`),n}(d),y=await async function(e,t,n,i){const s=function(e,t,n){const r=new Map;for(const i of e.getMonomerSymbolsByType(t)){const s=e.getMonomer(t,i);if("RNA"===t&&("Branch"===s.monomerType||n===a.YI.DNA&&s.symbol===l.DEOXYRIBOSE||n===a.YI.RNA&&s.symbol===l.RIBOSE||s.symbol===l.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==s.monomerType){const e={};u.f6.forEach((t=>{e[t]=s[t]})),r.set(s.symbol,e)}}return r}(t,n,i),o=new Map,c=await r.functions.call("Chem:getRdKitModule"),d={value:null};if("RNA"===n){const e=i===a.YI.RNA?[l.RIBOSE,l.PHOSPHATE]:[l.DEOXYRIBOSE,l.PHOSPHATE];for(const t of e)p(o,t,s,c,n,d)}for(let t=0;t<e.length;++t){const r=e[t];for(const e of r)if(""!==e)try{p(o,e,s,c,n,d)}catch(t){const n=t instanceof Error?t.message:t.toString(),r=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${r}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return o}(g,s,f,m),w=d.length,{molfileList:b,molfileWarningList:v}=await async function(e,t,r,i,s){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(n.p+n.u(248),n.b)))),c=s/o;let l=[],u=[];const d=new Array(o);for(let n=0;n<o;n++){const l=Math.floor(n*c),u=n===o-1?s:Math.floor((n+1)*c);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:r,polymerType:i,start:l,end:u}),d[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(d)).forEach((e=>{l=l.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:l,molfileWarningList:u}}(g,y,m,f,w);if(v.length>.05*w)throw new Error("Too many errors getting molfiles.");const A=`molfile(${d.name})`,E=e.columns.getUnusedName(A),C=i.Column.fromStrings(E,b);return C.semType=i.SEMTYPE.MOLECULE,C.meta.units=i.UNITS.Molecule.MOLBLOCK,{col:C,warnings:v}}function p(e,t,n,r,i,s){if(!e.has(t)){const o=function(e,t,n,r,i){if(t.has(e)){const o=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(o.rgroups),c=(s=o.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let r;for(;null!==(r=n.exec(e));)r.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(r[1]),parseInt(r[3]));return t}(s):function(e){const t=new Map;let n=e.indexOf(l.V2K_A_LINE,0),r=n;for(;-1!==n;){r=e.indexOf("\n",n);const i=parseInt(e.substring(n,r).replace(/^A\s+/,""));n=e.indexOf("R",r),r=e.indexOf("\n",n);const s=parseInt(e.substring(n,r).replace(/^R/,""));t.set(i,s),n=e.indexOf(l.V2K_A_LINE,r)}for(n=e.indexOf(l.V2K_RGP_LINE,0),r=e.indexOf("\n",n);-1!==n;){n+=l.V2K_RGP_SHIFT,r=e.indexOf("\n",n);const i=e.substring(n,r).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<i.length;e+=2){if(t.has(i[e])&&t.get(i[e])!==i[e+1])throw new Error(`r-group index ${i[e]} has already been added with a different value`);t.set(i[e],i[e+1])}n=e.indexOf(l.V2K_RGP_LINE,r)}return t}(s),u=o.molfile.includes("V3000")?o.molfile:function(e,t){const n=t.get_mol(e),r=n.get_v3Kmolblock();return n.delete(),r}(function(e){let t=e.indexOf(l.V2K_A_LINE,0);-1===t&&(t=e.indexOf(l.V2K_RGP_LINE));const n=e.indexOf(l.V3K_END,t);return e.substring(0,t)+e.substring(n)}(o.molfile),n),h=function(e){let t=(e=e.replaceAll("\r","")).indexOf(l.V3K_BEGIN_COUNTS_LINE)+l.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const r=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:r,bondCount:parseInt(e.substring(t,n))}}(u),p=function(e,t){const n=new Array(t),r=new Float32Array(t),i=new Float32Array(t),s=new Array(t);let o=e.indexOf(l.V3K_BEGIN_ATOM_BLOCK);o=e.indexOf("\n",o);let a=o;for(let c=0;c<t;c++){o=e.indexOf(l.V3K_BEGIN_DATA_LINE,o)+l.V3K_IDX_SHIFT,a=e.indexOf(" ",o),o=a+1,a=e.indexOf(" ",o),n[c]=e.substring(o,a);const t=new Array(2);for(let n=0;n<2;++n)o=a+1,a=e.indexOf(" ",o),t[n]=parseFloat(e.substring(o,a));r[c]=t[0],i[c]=t[1],o=a,a=e.indexOf("\n",o)+1,s[c]=e.slice(o,a),o=a}return{atomTypes:n,x:r,y:i,kwargs:s}}(u,h.atomCount),g=function(e,t){const n=new Uint32Array(t),r=new Array(t),i=new Map,s=new Map;let o=e.indexOf(l.V3K_BEGIN_BOND_BLOCK);o=e.indexOf("\n",o);let a=o;for(let c=0;c<t;++c){const t=new Array(3);o=e.indexOf(l.V3K_BEGIN_DATA_LINE,a)+l.V3K_IDX_SHIFT,a=e.indexOf(" ",o);for(let n=0;n<3;++n)o=a+1,a=Math.min(e.indexOf("\n",o),e.indexOf(" ",o)),t[n]=parseInt(e.slice(o,a));n[c]=t[0],r[c]=t.slice(1);const u=e.indexOf("\n",o);let d=e.slice(a,u),h=d.indexOf(l.V3K_BOND_CONFIG);if(-1!==h){h=d.indexOf("=",h)+1;let e=d.indexOf(" ",h);-1===e&&(e=d.length);const t=parseInt(d.slice(h,e));i.set(c,t);const n=l.V3K_BOND_CONFIG+t.toString();d=d.replace(n,"")}d||s.set(c,d)}return{bondTypes:n,atomPairs:r,bondConfiguration:i,kwargs:s}}(u,h.bondCount),w=function(e,t,n,r){const i={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[r,i]of n)e.atomTypes[r-1]=t[i-1]}(e,n,r),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const r of[1,2])if(e.get(t.rNodes[n])===r){const e=t.rNodes[r-1];t.rNodes[r-1]=t.rNodes[n],t.rNodes[n]=e}}(r,i),m(t,i),i}(p,g,a,c),C=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const r=e.indexOf(")",n);t=t.concat(e.substring(n,r).split(" ").slice(1).map((e=>parseInt(e)))),n=r,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),T={atoms:p,bonds:g,meta:w,stereoAtoms:C};return"PEPTIDE"===r?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,r=e.atoms.x,i=e.atoms.y;E(e,-r[t],-i[t]);const s=b(r[n],i[n]);v(e.atoms,-s),r[e.meta.rNodes[1]-1]<0&&function(e){A(e,!1)}(e);const o=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const r=n[e],i=n[(e+1)%2];t.has(r)?t.get(r)?.push(i):t.set(r,new Array(1).fill(i))}return t}(e);let n=0;const r=e.atoms.atomTypes.length;let i=0;for(;0===n;){const s=t.get(e.meta.terminalNodes[1])[i];if(e.atoms.atomTypes[s-1]===l.OXYGEN&&s!==e.meta.rNodes[1]&&(n=s),i++,i>r)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${r}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){A(e,!0)}(e),v(e.atoms,-function(e,t){return b(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,o),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const r=t-1,i=n-1,s=e.atoms.x,o=e.atoms.y,a=s[r],c=o[r];s[r]=s[i],o[r]=o[i],s[i]=a,o[i]=c}(e,t,e.meta.rNodes[1])}(e,o)}(T):e===l.RIBOSE||e===l.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,r=e.atoms.y;let i=e.meta.terminalNodes[0]-1;const s=e.meta.rNodes[1]-1;E(e,-n[i],-r[i]);const o=b(n[s],r[s]);v(e.atoms,3*Math.PI/2-o),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,r=e.meta.rNodes[2]-1,i=e.meta.terminalNodes[2]-1,s=t[r]-t[i],o=n[r]-n[i];return Math.atan(o/s)+Math.PI/2}(e),i=e.meta.terminalNodes[0]-1,E(e,-n[i],-r[i])}(T,i):e===l.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,r=e.atoms.x,i=e.atoms.y;E(e,-r[t],-i[t]);const s=b(r[n],i[n]);v(e.atoms,Math.PI/2-s)}(T):function(e,t){const n=e.atoms.x,r=e.atoms.y,i=e.meta.terminalNodes[0]-1,s=e.meta.rNodes[0]-1;E(e,-n[i],-r[i]);const o=b(n[s],r[s]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");v(e.atoms,Math.PI-o+a);const c=function(e,t){return d(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:r[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:r[e.meta.terminalNodes[0]-1]});if(1!=c)for(let e=0;e<n.length;++e)n[e]=d(n[e]/c),r[e]=d(r[e]/c)}(T,i),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===l.RIBOSE||n===l.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],m(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===l.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],E(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(r,T,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===l.HYDROGEN&&(y(e,t+1),--t),++t}(T),T}var s;return null}(t,n,r,i,s);if(!o)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,o)}}function m(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const r=t.terminalNodes,i=e.atomPairs;let s=0,o=0;for(;s<i.length&&o<r.length;){for(let e=0;e<r.length;++e)for(let t=0;t<2;++t)i[s][t]===n[e]&&(r[e]=i[s][(t+1)%2],n.length,++o);++s}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[d(e.atoms.x[t]-e.atoms.x[n]),d(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,r=e.atoms,i=e.bonds,s=e.meta;r.atomTypes.splice(n,1),r.x=w(Float32Array,r.x,n,1),r.y=w(Float32Array,r.y,n,1),r.kwargs.splice(n,1);for(let e=0;e<s.terminalNodes.length;++e)s.terminalNodes[e]>t?--s.terminalNodes[e]:s.terminalNodes[e]===t&&(s.terminalNodes[e]=-1);for(let e=0;e<s.rNodes.length;++e)s.rNodes[e]>t?--s.rNodes[e]:s.rNodes[e]===t&&(s.rNodes[e]=-1);let o=0;for(;o<i.atomPairs.length;){const e=i.atomPairs[o][0],n=i.atomPairs[o][1];e===t||n===t?(i.atomPairs.splice(o,1),i.bondTypes=w(Uint32Array,i.bondTypes,o,1),i.bondConfiguration.has(o)&&i.bondConfiguration.delete(o),i.kwargs.has(o)&&i.kwargs.delete(o),--o):(i.atomPairs[o][0]=e>t?e-1:e,i.atomPairs[o][1]=n>t?n-1:n),++o}let a=Array.from(i.bondConfiguration.keys());a.forEach((e=>{if(i.bondConfiguration.has(e)&&e>n){const t=i.bondConfiguration.get(e);i.bondConfiguration.delete(e),i.bondConfiguration.set(e-1,t)}})),a=Array.from(i.kwargs.keys()),a.forEach((e=>{if(i.kwargs.has(e)&&e>n){const t=i.kwargs.get(e);i.kwargs.delete(e),i.kwargs.set(e-1,t)}}))}}function w(e,t,n,r){const i=new e(t.length-r);let s=0,o=0;for(;s<t.length;)s===n&&(s+=r),i[o]=t[s],++o,++s;return i}function b(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const r=t/e,i=Math.atan(r);n=e<0?Math.PI/2+i:-Math.PI/2+i}return n}function v(e,t){if(0!==t){const n=e.x,r=e.y,i=Math.cos(t),s=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=d(t*i-r[e]*s),r[e]=d(t*s+r[e]*i)}}}function A(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const r=1===t?3:1;n.set(e,r)}}function E(e,t,n){const r=e.atoms.x,i=e.atoms.y;for(let e=0;e<r.length;++e)r[e]=d(r[e]+t),void 0!==n&&(i[e]=d(i[e]+n))}},1093:(e,t,n)=>{"use strict";n.d(t,{A:()=>i,Q:()=>s});var r=n(7362);class i extends r.e{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new i({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class s{}s.SemType="Nucleotides",s.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",s.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>r});class r{static makePalette(e,t=!1,n=r){const i={};return e.forEach((e=>{const n=e[0],r=e[1];n.forEach(((e,n)=>{i[e]=this.colourPalette[r][t?0:n]}))})),new n(i)}constructor(e){this._palette=e}get(e){return this._palette[e]}}r.undefinedColor="rgb(100,100,100)",r.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4152:(e,t,n)=>{"use strict";n.d(t,{$u:()=>o,oT:()=>l});var r=n(6082),i=n(7362);class s{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class o{}class a extends o{get(e){return"#666666"}}class c extends o{static buildPalette(){return[].concat(...Object.values(i.e.colourPalette))}get(e){const t=s.hashCode(e)%c.palette.length;return function(e){if(null==e)return"rgb(100,100,100)";const t=r.Color.fromHtml(e),n=r.Color.g(t),i=r.Color.r(t),s=r.Color.b(t),o=Math.sqrt(Math.pow(0-i,2)+Math.pow(0-n,2)+Math.pow(0-s,2));return o>210?`rgb(${i/o*210},${n/o*210},${s/o*210})`:r.Color.toRgb(t)}(c.palette[t])}}c.palette=c.buildPalette();class l extends i.e{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new c),this.color}}},6642:(e,t,n)=>{"use strict";n.d(t,{h:()=>o,s:()=>a});var r=n(4328),i=n(1858),s=n(8070);function o(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const r=e.cell.column;if(t=t??r.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,r,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new i.Subject,this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.tableCol&&this.subs.push(r.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(r.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,s.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},6882:(e,t,n)=>{"use strict";n.d(t,{B:()=>u,J:()=>d});var r=n(6082),i=n(1991),s=n.n(i),o=n(826),a=n(6642),c=n(6718),l=n(9192);function u(e,t){let n,r=100,i=0,s=e.length-1;for(;i<=s;){if(n=Math.floor((s+i)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?s=n-1:i=n+1,--r<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}class d extends a.s{constructor(e,t,n,i,s){super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=s,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,c.pj)().then((e=>{if(this.destroyed)return;const t=e.getMonomerLib();this.subs.push(t.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset()}getCellMonomerLengths(e,t){if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,l.AP)(e);this.logger.error(t,void 0,n)}const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),r=new Array(n.length+1);r[0]=5;for(let e=1;e<r.length;e++)r[e]=r[e-1]+n[e-1];return[n,r]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),r=o.GO.forColumn(this.tableCol).getSplitted(e).originals,i=Math.min(n,r.length);let s=this._monomerLengthList[e];if(null===s||s.length<i){s=this._monomerLengthList[e]=new Array(r.length);let t=0;for(let e=0;e<i;++e){const n=r[e],i=this.props.monomerToShort(n,this.monomerLengthLimit),o=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+i.length*this.props.monomerCharWidth;if(s[e]=o,t+=o,t>this.colWidth)break}}return s}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:r}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),i=this.props.separatorWidth+1*this.props.monomerCharWidth,s=Math.ceil(this.colWidth/i);for(let e=n;e<r;e++){if(this._processedRows.get(e)&&s<=this._processedMaxVisibleSeqLength)continue;const n=o.GO.forColumn(this.tableCol).getSplitted(e,s).originals,r=Math.min(s,n.length);r>t.length&&t.push(...new Array(r-t.length).fill(i));let a=0;for(let e=0;e<r;++e){const r=n[e],i=this.props.monomerToShort(r,this.monomerLengthLimit),s=this.props.separatorWidth+i.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s)}return t}getPosition(e,t,n){const[r,i]=this.getCellMonomerLengths(e,n),a=o.GO.forColumn(this.tableCol);return 0===s()(a.getSplitted(e).originals).toArray().length?null:u(i,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.dirty=!0}setSeparatorWidth(e){this.props.separatorWidth=e,this.dirty=!0}isMsa(){return this.props.seqHandler.isMsa()}}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>s,f6:()=>r,q7:()=>i});const r=["symbol","molfile","rgroups","name"],i="p",s=new RegExp(`[rd]\\((\\w)\\)${i}?`,"g")},9192:(e,t,n)=>{"use strict";function r(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function i(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):void 0}function s(e){return[r(e),i(e)]}n.d(t,{AP:()=>s})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>o});var r=n(6082),i=n(826),s=n(439);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const r=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(r),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=r.Column.fromStrings("description",this.descriptionsArray),t=r.Column.fromStrings("sequence",this.sequencesArray);return t.semType=r.SEMTYPE.MACROMOLECULE,t.meta.units=s.Hi.FASTA,i.GO.forColumn(t),[r.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{dW:()=>o,fD:()=>s});var r=n(6082),i=(n(1991),n(2003));function s(){const e=[];return e.push(r.Column.fromList("string","MSA",new Array(10**6).fill("meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"))),e.push(r.Column.fromList(r.COLUMN_TYPE.FLOAT,"Activity",new Array(10**6).fill(5.30751))),e}function o(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=r.Column.fromList(r.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=r.SEMTYPE.MACROMOLECULE,n.meta.units=i.Hi.SEPARATOR,n.setTag(i.gp.separator,"/"),n.setTag(i.gp.alphabet,i.YI.UN),n.setTag(i.gp.alphabetIsMultichar,"true");const s=[];return s.push(n),s.push(r.Column.fromList(r.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),s}n(826),n(9322)},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>c,Hi:()=>r,Vl:()=>l,YI:()=>i,gp:()=>s,q7:()=>u,z1:()=>a});var r,i,s,o=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(r||(r={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(i||(i={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(s||(s={}));const a=", ",c=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,l=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new o.aD(i.PT,l.fasta.peptide,.5),new o.aD(i.DNA,l.fasta.dna,.55),new o.aD(i.RNA,l.fasta.rna,.55)]},2003:(e,t,n)=>{"use strict";n.d(t,{Hi:()=>r.Hi,J9:()=>i.J9,Qf:()=>i.Qf,SM:()=>i.SM,YI:()=>r.YI,dh:()=>i.dh,gp:()=>r.gp,mn:()=>i.mn,nq:()=>i.nq,ny:()=>i.ny,q7:()=>r.q7,qp:()=>i.qp,z1:()=>r.z1,zS:()=>i.zS});var r=n(439),i=n(9322)},2738:(e,t,n)=>{"use strict";n.d(t,{XN:()=>s,_S:()=>r,aD:()=>i});const r="";class i{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class s extends i{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},9322:(e,t,n)=>{"use strict";n.d(t,{Mu:()=>m,pc:()=>P,Qf:()=>_,nq:()=>x,ny:()=>$,Iv:()=>C,dh:()=>b,vZ:()=>g,zS:()=>S,SM:()=>M,mn:()=>N,J9:()=>y,tm:()=>w,qp:()=>E});var r=n(6082),i=n(1991),s=n.n(i),o=n(2738),a=n(439),c=n(826);class l extends Float32Array{}var u=n(3629),d=n(8924),h=n(1093),p=n(4152);class m{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===c.b9[a.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?o._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}function g(e,t,n){const r=e.categories;return function(e,t){const n={};let r=!0,i=null;for(const s of e)if(null==i?i=s.length:s.length!==i&&(r=!1),s.length>=t)for(const e of s.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:r}}(s().enumerate(e.getRawData()).map((([e,t])=>n(r[e]))),t)}const y=e=>{const t=s()(e.toString().matchAll(a.B5)).map((e=>e[2]??e[1])).toArray();return new m(t,c.b9[a.Hi.FASTA])},w=e=>e?new f(e):new m([],c.b9[a.Hi.FASTA]);function b(e,t=void 0){return n=>{if(n){let r;const i=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){i.lastIndex=0,r=new Array(Math.ceil(t));let e=null,s=0;for(;null!==(e=i.exec(n))&&s<t;)r[s++]=e[0].replace('"-"',"").replace("'-'","");r.splice(s)}else r=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new m(r,c.b9[a.Hi.SEPARATOR])}return new m([],c.b9[a.Hi.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,A=/\[([^\[\]]+)]/g,E=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,r=n?n.split("."):[];return new m(r.map((e=>{A.lastIndex=0;const t=A.exec(e);return t&&t.length>=2?t[1]:e})),c.b9[a.Hi.HELM])};function C(e,t,n=void 0){if(e.toLowerCase().startsWith(a.Hi.FASTA))return y;if(e.toLowerCase().startsWith(a.Hi.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.Hi.HELM))return E;throw new Error(`Unexpected units ${e} .`)}const T=/([^\W_]+)/g;function S(e,t){if(e.length<=t)return e;const n=e.match(T),r=e.length>t||(n?.length??0)>1,i=n?.[0]??" ";return r?i.substring(0,t-1)+"…":i}function _(e){switch(e){case a.YI.DNA:return a.Vl.fasta.dna;case a.YI.RNA:return a.Vl.fasta.rna;case a.YI.PT:return a.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function x(e,t,n="-"){const r=new Set([...new Set(Object.keys(e)),...t]);r.delete(n);const i=[],s=[];for(const n of r)i.push(n in e?e[n]:0),s.push(t.has(n)?1:0);const o=new l(i),a=new l(s);return(0,u.KE)(o,a)/((0,u.wQ)(o)*(0,u.wQ)(a))}function P(e,t,n="-"){const r=t.map((t=>{const r=x(e,t.alphabet,n);return new o.XN(t,e,r)}));let i;const s=Math.max(...r.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return i=s>0?r.find((e=>e.similarity===s)).name:a.YI.UN,i}function M(e,t=5){let n;return n=e.semType==r.SEMTYPE.MACROMOLECULE?c.GO.forColumn(e).alphabet:P(g(e,t,y).freq,a.q7),$(n)}function $(e){switch(e){case a.YI.PT:return d.X.GrokGroups;case a.YI.DNA:case a.YI.RNA:return h.A.Chromatogram;default:return p.oT.Color}}function N(e){const t=e.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},826:(e,t,n)=>{"use strict";n.d(t,{GO:()=>m,b9:()=>p});var r=n(6082),i=n(1991),s=n.n(i),o=n(2003),a=n(2738),c=n(9322),l=n(6863),u=n(6718),d=n(3151);const h=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},p={[o.Hi.FASTA]:"-",[o.Hi.SEPARATOR]:"",[o.Hi.HELM]:"*"};class m{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==r.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${r.TYPE.STRING}'.`);this._column=e;const t=this._column.meta.units;if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?p[o.Hi.FASTA]:this.isHelm()?p[o.Hi.HELM]:p[o.Hi.SEPARATOR],!this.column.tags.has(o.gp.aligned)||!this.column.tags.has(o.gp.alphabet)||!this.column.tags.has(o.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===o.YI.UN)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(o.gp.separator);m.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.meta.units}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(o.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(o.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${o.gp.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[h.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE||e.column.meta.units!==o.Hi.FASTA)throw new Error(`The column of notation '${o.Hi.FASTA}' must be '${r.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=o.Hi.FASTA,m.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE||e.column.meta.units!==o.Hi.SEPARATOR)throw new Error(`The column of notation '${o.Hi.SEPARATOR}' must be '${r.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${o.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=o.Hi.SEPARATOR,e.column.setTag(o.gp.separator,t),m.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.Hi.HELM}' must be '${r.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=o.Hi.HELM,m.setTags(e)}static setTags(e){const t=e.column.meta.units;if([o.Hi.FASTA,o.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(o.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(o.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(o.gp.aligned,t));let n=e.column.getTag(o.gp.alphabet);if(null===n&&(n=(0,c.pc)(e.stats.freq,o.q7),e.column.setTag(o.gp.alphabet,n)),n===o.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(o.gp.alphabetSize,t.toString()),e.column.setTag(o.gp.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(o.gp.separator)??void 0;if(this.notation===o.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(o.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(o.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(o.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==o.Hi.HELM||this.alphabet==o.YI.UN){const e=this.column.getTag(o.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case o.YI.PT:return 20;case o.YI.DNA:case o.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.Hi.HELM||this.alphabet===o.YI.UN&&"true"===this.column.getTag(o.gp.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}async getHelm(e,t){const n=this.column.get(e);return this.notationProvider?(await this.notationProvider.getHelm(this.column,t)).get(e):this.convertToHelm(n)}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const r=this.column.length;for(let i=0;i<r;++i){const r=this.getSplitted(i);null==n?n=r.length:r.length!==n&&(t=!1);for(const t of r.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...s().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(o.gp.positionNames);this._posList=e?e.split(o.z1).map((e=>e.trim())):s().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.Hi.FASTA}isSeparator(){return this.notation===o.Hi.SEPARATOR}isHelm(){return this.notation===o.Hi.HELM}isRna(){return this.alphabet===o.YI.RNA}isDna(){return this.alphabet===o.YI.DNA}isPeptide(){return this.alphabet===o.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(o.Hi.FASTA))return o.Hi.FASTA;if(this.units.toLowerCase().startsWith(o.Hi.SEPARATOR))return o.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(o.Hi.HELM))return o.Hi.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const s=this.column,a=e.toLowerCase()+"("+s.name+")",c=n??s.dataFrame.columns.getUnusedName(a),l=r.Column.fromList("string",c,i??new Array(this.column.length).fill(""));if(l.semType=r.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===o.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${o.Hi.SEPARATOR}' requires separator value.`);l.setTag(o.gp.separator,t)}l.setTag(r.TAGS.CELL_RENDERER,e===o.Hi.HELM?"helm":"sequence");const u=s.getTag(o.gp.aligned);u&&l.setTag(o.gp.aligned,u);let d=s.getTag(o.gp.alphabet);d||this.notation!==o.Hi.HELM||e===o.Hi.HELM||(d=o.YI.UN),null!=d&&l.setTag(o.gp.alphabet,d);let h=s.getTag(o.gp.alphabetSize);null!=d&&h&&l.setTag(o.gp.alphabetSize,h);const p=s.getTag(o.gp.alphabetIsMultichar);return null!=d&&void 0!==p&&l.setTag(o.gp.alphabetIsMultichar,p),e==o.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(o.gp.alphabetSize,h)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=m.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[o.Hi.FASTA,o.Hi.SEPARATOR,o.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!m.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=r.Column.fromList("string",t,new Array(e).fill(""));return i.semType=r.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(o.Hi.FASTA))return null===this.column.getTag(o.gp.alphabet)||this.getAlphabetIsMultichar()?o.J9:c.tm;if(this.units.toLowerCase().startsWith(o.Hi.SEPARATOR))return(0,o.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(o.Hi.HELM))return o.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return l.Z.HAMMING;switch(this.alphabet){case o.YI.DNA:case o.YI.RNA:case o.YI.PT:}return l.Z.LEVENSHTEIN}getDistanceFunction(){return l.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(o.gp.isHelmCompatible))return"true"===this.column.getTag(o.gp.isHelmCompatible);const e=(await(0,u.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,o.dh)(this.separator),new Set),r=this.column.length,i=this.column.getRawData();for(let e=0;e<r;++e){const r=i[e];if(!(r in n)){n.add(r);const i=this.getSplitted(e);for(const e of i.canonicals)if(!t.has(e))return this.column.setTag(o.gp.isHelmCompatible,"false"),!1}}return this.column.setTag(o.gp.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===o.Hi.FASTA}toSeparator(e){return e===o.Hi.SEPARATOR}toHelm(e){return e===o.Hi.HELM}convertHelmToFastaSeparator(e,t,n,r){r||(r=this.toFasta(t)?p[o.Hi.FASTA]:p[o.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const i=e.startsWith("RNA"),s=this.splitter(e),a=[];for(let e=0;e<s.length;++e){let n=s.getOriginal(e);if(i&&(n=n.replace(d.EK,"")),n===p[o.Hi.HELM])a.push(r);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),r=this.getNewColumn(e,t);return r.init((e=>{const t=this.getSplitted(e);return n(t)})),r}getRegion(e,t,n){const r=this.getNewColumn(this.notation,this.separator);r.name=n;const i=e??0,s=t??this.maxLength-1,a=this.getJoiner(),l=s-i+1,u=p[this.notation];r.init((e=>{const t=this.getSplitted(e),n=new Array(l);for(let e=0;e<l;++e){const r=i+e;n[e]=r<t.length?t.getOriginal(r):u}return a(new c.Mu(n,u))}));const d=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(l);for(let e=0;e<l;++e){const r=i+e;n[e]=r<t.length?t[r]:"?"}return n.join(o.z1)},h=this.column.getTag(o.gp.positionNames);h&&r.setTag(o.gp.positionNames,d(h));const m=this.column.getTag(o.gp.positionLabels);return m&&r.setTag(o.gp.positionLabels,d(m)),r}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let r;const i=this;switch(t){case o.Hi.FASTA:r=function(e){return i.joinToFasta(e,i.isHelm())};break;case o.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);r=function(e){return f(e,n,i.isHelm())};break;case o.Hi.HELM:{const e=i.alphabet===o.YI.DNA||i.alphabet===o.YI.RNA,t=i.getHelmWrappers();r=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return r}getConverter(e,t=void 0){if(e===o.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${o.Hi.SEPARATOR}'.`);const n=this;if(e===o.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===o.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===o.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[h.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[h.seqHandler]=new m(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let r=0;r<e.length;++r){const i=e.getOriginal(r);let s=e.getOriginal(r);t&&(s=s.replace(d.EK,"$1")),i===a._S?s=p[o.Hi.FASTA]:i===d.q7?s="":s.length>1&&(s="["+s+"]"),n[r]=s}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==o.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),r=e.startsWith("DNA"),i=e.startsWith("RNA");for(let e=0;e<t.length;++e){let s=t.getOriginal(e);(r||i)&&(s=s.replace(d.EK,"$1"),s=s===d.q7?null:s),n[e]=s||null}return new c.Mu(n.filter((e=>!!e)),p[o.Hi.HELM])}}function f(e,t,n){const r=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=e.getOriginal(t);n&&(s=s.replace(d.EK,"$1")),i===a._S?s=p[o.Hi.SEPARATOR]:i===d.q7&&(s=""),r[t]=s}return r.join(t)}function g(e,t,n){const[r,i,s,c]=t,l=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let c=e.getOriginal(t);r===a._S?c=p[o.Hi.HELM]:(n&&(c=c.replace(d.EK,"$1")),c=1===c.length?`${i}${c}${s}`:`${i}[${c}]${s}`),l[t]=c}return`${r}${l.join(".")}${c}`}},8312:(e,t,n)=>{"use strict";n.d(t,{Q:()=>i});var r=n(6082);async function i(){const e=r.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>s});var r=n(6082),i=n(826);function s(e){const t=e=>{const t=o.columns.addNewString((e+1).toString());return n.push(t),t},n=[],s=e.length,o=r.DataFrame.create(s),a=i.GO.forColumn(e);for(let e=0;e<s;++e){const r=a.getSplitted(e);for(let i=0;i<r.length;++i){const s=r.getOriginal(i);((n[i]??null)||t(i)).set(e,s,!1)}}return o}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>s});var r,i=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(r||(r={}));class s{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[r,s]=(0,i.AP)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${r}`,void 0,s),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},4326:(e,t,n)=>{"use strict";n.d(t,{Fo:()=>u,Lp:()=>s,P4:()=>o,fH:()=>i,gp:()=>r,lT:()=>c,mH:()=>a});var r,i,s,o,a,c,l=n(6082);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(r||(r={})),function(e){e.Entropy="Entropy",e.full="100%"}(i||(i={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(s||(s={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(o||(o={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(c||(c={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=l.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=i.Entropy,this.positionWidth=16,this.verticalAlignment=s.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=c.Filtered}}},5540:(e,t,n)=>{"use strict";e=n.hmd(e);var r,i=(r="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,i=void 0!==e?e:{};i.ready=new Promise((function(e,r){t=e,n=r}));var s,o=Object.assign({},i),a="object"==typeof window,c="function"==typeof importScripts,l=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||c)&&(c?l=self.location.href:"undefined"!=typeof document&&document.currentScript&&(l=document.currentScript.src),r&&(l=r),l=0!==l.indexOf("blob:")?l.substr(0,l.replace(/[?#].*/,"").lastIndexOf("/")+1):"",c&&(s=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),i.print||console.log.bind(console);var u,d,h=i.printErr||console.warn.bind(console);Object.assign(i,o),o=null,i.arguments&&i.arguments,i.thisProgram&&i.thisProgram,i.quit&&i.quit,i.wasmBinary&&(u=i.wasmBinary),i.noExitRuntime,"object"!=typeof WebAssembly&&T("no native wasm support detected");var p,m,f,g=!1;function y(){var e=d.buffer;i.HEAP8=p=new Int8Array(e),i.HEAP16=new Int16Array(e),i.HEAP32=new Int32Array(e),i.HEAPU8=m=new Uint8Array(e),i.HEAPU16=new Uint16Array(e),i.HEAPU32=f=new Uint32Array(e),i.HEAPF32=new Float32Array(e),i.HEAPF64=new Float64Array(e)}var w=[],b=[],v=[],A=0,E=null,C=null;function T(e){i.onAbort&&i.onAbort(e),h(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var S,_;function x(e){return e.startsWith("data:application/octet-stream;base64,")}function P(e){try{if(e==S&&u)return new Uint8Array(u);if(s)return s(e);throw"both async and sync fetching of the wasm failed"}catch(e){T(e)}}function M(e,t,n){return function(e){return u||!a&&!c||"function"!=typeof fetch?Promise.resolve().then((function(){return P(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return P(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){h("failed to asynchronously prepare wasm: "+e),T(e)}))}function $(e){for(;e.length>0;)e.shift()(i)}function N(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,p[this.ptr+12|0]=e},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(e){e=e?1:0,p[this.ptr+13|0]=e},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(U(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function L(e){var t=d.buffer;try{return d.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function I(e){return i["_"+e]}x(S="wasmDbscan.wasm")||(_=S,S=i.locateFile?i.locateFile(_,l):l+_);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(e,t,n,r,i){var s={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var r=e.charCodeAt(n);r<=127?t++:r<=2047?t+=2:r>=55296&&r<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=F(t);return function(e,t,n){!function(e,t,n,r){if(!(r>0))return 0;for(var i=n+r-1,s=0;s<e.length;++s){var o=e.charCodeAt(s);if(o>=55296&&o<=57343&&(o=65536+((1023&o)<<10)|1023&e.charCodeAt(++s)),o<=127){if(n>=i)break;t[n++]=o}else if(o<=2047){if(n+1>=i)break;t[n++]=192|o>>6,t[n++]=128|63&o}else if(o<=65535){if(n+2>=i)break;t[n++]=224|o>>12,t[n++]=128|o>>6&63,t[n++]=128|63&o}else{if(n+3>=i)break;t[n++]=240|o>>18,t[n++]=128|o>>12&63,t[n++]=128|o>>6&63,t[n++]=128|63&o}}t[n]=0}(e,m,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,r=F(e.length);return t=e,n=r,p.set(t,n),r}},o=I(e),a=[],c=0;if(r)for(var l=0;l<r.length;l++){var u=s[n[l]];u?(0===c&&(c=H()),a[l]=u(r[l])):a[l]=r[l]}var d=o.apply(null,a);return function(e){return 0!==c&&D(c),function(e){return"string"===t?(n=e)?function(e,t,n){for(var r=t+n,i=t;e[i]&&!(i>=r);)++i;if(i-t>16&&e.buffer&&R)return R.decode(e.subarray(t,i));for(var s="";t<i;){var o=e[t++];if(128&o){var a=63&e[t++];if(192!=(224&o)){var c=63&e[t++];if((o=224==(240&o)?(15&o)<<12|a<<6|c:(7&o)<<18|a<<12|c<<6|63&e[t++])<65536)s+=String.fromCharCode(o);else{var l=o-65536;s+=String.fromCharCode(55296|l>>10,56320|1023&l)}}else s+=String.fromCharCode((31&o)<<6|a)}else s+=String.fromCharCode(o)}return s}(m,n,r):"":"boolean"===t?Boolean(e):e;var n,r}(e)}(d)}var k,G={__cxa_throw:function(e,t,n){throw new N(e).init(t,n),e},abort:function(){T("")},emscripten_memcpy_big:function(e,t,n){m.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=m.length,r=2147483648;if((e>>>=0)>r)return!1;for(var i=1;i<=4;i*=2){var s=n*(1+.2/i);if(s=Math.min(s,e+100663296),L(Math.min(r,(t=Math.max(e,s))+(65536-t%65536)%65536)))return!0}return!1}},H=(function(){var e,t,r,s,o={env:G,wasi_snapshot_preview1:G};function a(e,t){var n,r=e.exports;return i.asm=r,d=i.asm.memory,y(),i.asm.__indirect_function_table,n=i.asm.__wasm_call_ctors,b.unshift(n),function(){if(A--,i.monitorRunDependencies&&i.monitorRunDependencies(A),0==A&&(null!==E&&(clearInterval(E),E=null),C)){var e=C;C=null,e()}}(),r}if(A++,i.monitorRunDependencies&&i.monitorRunDependencies(A),i.instantiateWasm)try{return i.instantiateWasm(o,a)}catch(e){h("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=S,r=o,s=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||x(t)||"function"!=typeof fetch?M(t,r,s):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,r).then(s,(function(e){return h("wasm streaming compile failed: "+e),h("falling back to ArrayBuffer instantiation"),M(t,r,s)}))}))).catch(n)}(),i._dbscan=function(){return(i._dbscan=i.asm.dbscan).apply(null,arguments)},i._malloc=function(){return(i._malloc=i.asm.malloc).apply(null,arguments)},i._free=function(){return(i._free=i.asm.free).apply(null,arguments)},function(){return(H=i.asm.stackSave).apply(null,arguments)}),D=function(){return(D=i.asm.stackRestore).apply(null,arguments)},F=function(){return(F=i.asm.stackAlloc).apply(null,arguments)},U=function(){return(U=i.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function e(){k||(k=!0,i.calledRun=!0,g||($(b),t(i),i.onRuntimeInitialized&&i.onRuntimeInitialized(),function(){if(i.postRun)for("function"==typeof i.postRun&&(i.postRun=[i.postRun]);i.postRun.length;)e=i.postRun.shift(),v.unshift(e);var e;$(v)}()))}A>0||(function(){if(i.preRun)for("function"==typeof i.preRun&&(i.preRun=[i.preRun]);i.preRun.length;)e=i.preRun.shift(),w.unshift(e);var e;$(w)}(),A>0||(i.setStatus?(i.setStatus("Running..."),setTimeout((function(){setTimeout((function(){i.setStatus("")}),1),e()}),1)):e()))}if(i.ccall=O,i.cwrap=function(e,t,n,r){var i=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&i&&!r?I(e):function(){return O(e,t,n,arguments)}},C=function e(){k||V(),k||(C=e)},i.preInit)for("function"==typeof i.preInit&&(i.preInit=[i.preInit]);i.preInit.length>0;)i.preInit.pop()();return V(),e.ready});"object"==typeof exports?e.exports=i:"function"==typeof define&&n.amdO?define([],(function(){return i})):"object"==typeof exports&&(exports.exportCppDbscanLib=i)},6295:(e,t,n)=>{"use strict";n.d(t,{$1:()=>a,Hr:()=>C,Ii:()=>m,T6:()=>E,TK:()=>v,a4:()=>h,be:()=>p,gt:()=>y,iS:()=>o,ij:()=>w,lO:()=>d,lP:()=>g,rR:()=>f,tO:()=>c,v_:()=>l,yK:()=>b,zn:()=>u});var r=n(8774),i=n(8498),s=n(6863);i.aT.Tanimoto,i.aT.Dice,i.aT.Asymmetric,i.aT.BraunBlanquet,i.aT.Cosine,i.aT.Kulczynski,i.aT.McConnaughey,i.aT.RogotGoldberg,i.aT.Russel,i.aT.Sokal,i.aT.Hamming,i.aT.Euclidean,i.aT.Tanimoto,i.aT.Dice,i.aT.Asymmetric,i.aT.BraunBlanquet,i.aT.Cosine,i.aT.Kulczynski,i.aT.McConnaughey,i.aT.RogotGoldberg,i.aT.Russel,i.aT.Sokal,i.aT.Hamming,i.aT.Euclidean;const o=[i.aT.Tanimoto,i.aT.Dice,i.aT.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const r=e.andWithCountBits(t,!0);return r/(n-r)}function c(e,t){return 1-a(e,t)}function l(e,t){return A(a(new r.A(e,32*e.length),new r.A(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function d(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function h(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function p(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function m(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),r=e.andWithCountBits(t,!0);return r/(2*n-3*r)}(e,t)}function f(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),r=e.trueCount()*t.trueCount();return 0==r?0:e.andWithCountBits(t,!0)*n/(2*r)}(e,t))}function g(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),r=e.trueCount()*t.trueCount();return 0==r?0:(e.andWithCountBits(t,!0)*n-r)/r}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function w(e,t){return A(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function b(e,t){return A(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function v(e,t){return A(function(e,t){const n=e.andWithCountBits(t,!0),r=e.countBits(!0)+t.countBits(!0),i=e.length,s=i-r+n;return n==i||s==i?1:n/r+s/(2*i-r)}(e,t))}function A(e){return 0===e?3402823e32:1/e-1}function E(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function C(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const r=e.length,i=n.length;let s=0,o=0,a=0;for(;o<r&&a<i;)e[o]===n[a]?(t?.has(e[o])||++s,++o,++a):e[o]<n[a]?++o:++a;return s}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}i.aT.Tanimoto,i.aT.Asymmetric,i.aT.Cosine,i.aT.Sokal,s.Z.HAMMING,s.Z.LEVENSHTEIN,s.Z.MONOMER_CHEMICAL_DISTANCE,s.Z.NEEDLEMANN_WUNSCH},684:(e,t,n)=>{"use strict";n.d(t,{C0:()=>s,GP:()=>r,Gi:()=>a,YP:()=>l,_X:()=>o,n3:()=>i,vb:()=>c});const r="dim-red-preprocessing-function",i="supportedSemTypes",s="supportedTypes",o="supportedUnits",a="supportedDistanceFunctions",c="bypassLargeDataWarning",l="show-scatterplot-progress"},6863:(e,t,n)=>{"use strict";function r(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,r=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,i=new Float32Array((n.length+r)*(n.length+r));return Object.entries(t).forEach((([e,r])=>{const s=n[r];Object.entries(t).forEach((([t,r])=>{i[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=s[r]}))})),(e,t)=>1-i[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,r)=>{let i=0;const s=e.length,o=r.length,a=Math.ceil(Math.max(s,o)*(1-n));s!==o&&(i=Math.abs(s-o));let c=0;for(let n=0;n<Math.min(s,o);n++)if(e[n]!==r[n]&&(c+=t(e[n],r[n]),c>a))return 1;return c+=i,c/=Math.max(s,o),c}}n.d(t,{Z:()=>o,V:()=>a});var i=n(2787);const s={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var o;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(o||(o={}));const a={[o.HAMMING]:r,[o.LEVENSHTEIN]:function(){return(e,t)=>(0,i.I)(e,t)/Math.max(e.length,t.length)},[o.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:r,scoringMatrix:i,alphabetIndexes:o}={...s,...e};Object.entries(o).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,s)=>{const o=new Array(e.length+1).fill(!1),c=new Array(e.length+1).fill(!1);let l=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-r-(t-1)*r,a[1][t]=0;a[0][0]=0;for(let d=1;d<s.length+1;d++){a[u][0]=-r-(d-1)*r;for(let h=1;h<e.length+1;h++){const p=a[l][h-1]+i[t[e.charCodeAt(h-1)]][t[s.charCodeAt(d-1)]],m=a[l][h]-(o[h]||1===d||d===s.length?r:n),f=a[u][h-1]-(c[h-1]||1===h||h===e.length?r:n);a[u][h]=Math.max(p,f,m),a[u][h]===p?(o[h]=!1,c[h]=!1):a[u][h]===f?(o[h]=!1,c[h]=!0):(o[h]=!0,c[h]=!1)}l=u,u=(u+1)%2}const d=Math.min(e.length,s.length);return(d-a[l][e.length])/d}},[o.MONOMER_CHEMICAL_DISTANCE]:r}},9039:(e,t,n)=>{"use strict";var r;n.d(t,{c:()=>r}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(r||(r={}))},8498:(e,t,n)=>{"use strict";var r,i,s,o,a,c,l;n.d(t,{EG:()=>a,Pn:()=>i,RR:()=>c,Wn:()=>l,aT:()=>s,m6:()=>o,xL:()=>r}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(r||(r={})),function(e){e.Euclidean="Euclidean"}(i||(i={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(s||(s={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(o||(o={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(c||(c={})),function(e){e.CommonItems="Common Items"}(l||(l={}))},2780:(e,t,n)=>{"use strict";n.d(t,{aT:()=>r.aT});var r=n(8498);n(9336)},9336:(e,t,n)=>{"use strict";var r=n(2787),i=n(944),s=n(6295),o=n(3629),a=n(6863),c=n(8498);const l={[c.Pn.Euclidean]:o.ou},u={[c.xL.Levenshtein]:r.I,[c.xL.JaroWinkler]:i.Vb,[c.xL.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let r=1;r<e.length;r++)n+=e[r]==t[r]?0:1;return n/e.length}},[c.xL.Onehot]:function(e,t){return e===t?0:1}},d={[c.aT.Tanimoto]:s.tO,[c.aT.Dice]:s.zn,[c.aT.Asymmetric]:s.gt,[c.aT.BraunBlanquet]:s.ij,[c.aT.Cosine]:s.lO,[c.aT.Kulczynski]:s.rR,[c.aT.McConnaughey]:s.lP,[c.aT.RogotGoldberg]:s.TK,[c.aT.Russel]:s.yK,[c.aT.Sokal]:s.Ii,[c.aT.Hamming]:s.be,[c.aT.Euclidean]:s.a4},h={[c.m6.TanimotoIntArray]:s.v_},p={[c.RR.Difference]:s.T6},m={[c.Wn.CommonItems]:s.Hr},f={[c.EG.Vector]:{[c.Pn.Euclidean]:l[c.Pn.Euclidean]},[c.EG.String]:{[c.xL.Levenshtein]:u[c.xL.Levenshtein],[c.xL.JaroWinkler]:u[c.xL.JaroWinkler],[c.xL.Manhattan]:u[c.xL.Manhattan],[c.xL.Onehot]:u[c.xL.Onehot]},[c.EG.BitArray]:{[c.aT.Tanimoto]:d[c.aT.Tanimoto],[c.aT.Dice]:d[c.aT.Dice],[c.aT.Asymmetric]:d[c.aT.Asymmetric],[c.aT.BraunBlanquet]:d[c.aT.BraunBlanquet],[c.aT.Cosine]:d[c.aT.Cosine],[c.aT.Kulczynski]:d[c.aT.Kulczynski],[c.aT.McConnaughey]:d[c.aT.McConnaughey],[c.aT.RogotGoldberg]:d[c.aT.RogotGoldberg],[c.aT.Russel]:d[c.aT.Russel],[c.aT.Sokal]:d[c.aT.Sokal]},[c.EG.MacroMolecule]:{[a.Z.HAMMING]:a.V[a.Z.HAMMING],[a.Z.LEVENSHTEIN]:a.V[a.Z.LEVENSHTEIN],[a.Z.NEEDLEMANN_WUNSCH]:a.V[a.Z.NEEDLEMANN_WUNSCH],[a.Z.MONOMER_CHEMICAL_DISTANCE]:a.V[a.Z.MONOMER_CHEMICAL_DISTANCE]},[c.EG.Number]:{[c.RR.Difference]:p[c.RR.Difference]},[c.EG.IntArray]:{[c.m6.TanimotoIntArray]:h[c.m6.TanimotoIntArray]},[c.EG.NumberArray]:{[c.Wn.CommonItems]:m[c.Wn.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},8774:(e,t,n)=>{"use strict";n.d(t,{A:()=>r});class r{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,i=r._createBuffer(n);if(t)for(let e=0;e<i.length;e++)i[e]=-1;this._data=i,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,r){if(e<t||e>n)throw new Error(`Argument ${r} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let r=0;r<n;r++)t[r]=e[r]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new r(e._length);n._length=e._length,n._data=r._createBuffer(n._length),n._version=0;const i=e.lengthInInts;for(let r=0;r<i;r++)n._data[r]=e._data[r]&t._data[r];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new r(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new r(e);for(let r=0;r<e;++r)n.setBit(r,t(r));return n._version=0,n}static fromString(e){return r.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new r(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new r(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let i=0,s=0;for(;t-s>=4;)n._data[i++]=255&e[s]|(255&e[s+1])<<8|(255&e[s+2])<<16|(255&e[s+3])<<24,s+=4;return t-s==3&&(n._data[i]=(255&e[s+2])<<16),t-s==2&&(n._data[i]|=(255&e[s+1])<<8),t-s==1&&(n._data[i]|=255&e[s]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new r(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,r=this.lengthInInts;for(let e=0;e<r;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,r=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(r)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,r=!0,i=!0){if(n&&i&&this.setAll(!t,!1),i)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(r)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let r=e;r<t;++r)n.push(this.getBit(r));return r.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let r=e;r<t;++r)n.push(this.getBit(r));return n}setRange(e,t,n,r=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const i=Math.min(e,t),s=Math.max(e,t);if(n)for(let e=i;e<=s;e++)this.setTrue(e);else for(let e=i;e<=s;e++)this.setFalse(e);return this.incrementVersion(r),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const r=this._length;this.setLength(this._length+t);for(let n=r-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let r=e;r<e+t;r++)this.setBit(r,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let r=-1;-1!=(r=e.findNext(r,!t));)this.setFast(n++,this.getBit(r));this._length=n,this._version++}return this}getBit(e){return!!(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=r._onBitCount[255&e];let n=this._data[t];const i=31&this._length;for(0!=i&&(n&=~(4294967295<<i));0!=n;n>>>=8)this._selectedCount+=r._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const i=this.lengthInInts;let s=0;for(;s<i-1;s++)for(let t=this._data[s]&e._data[s];0!=t;t>>>=8)n+=r._onBitCount[255&t];let o=this._data[s]&e._data[s];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)n+=r._onBitCount[255&o];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const i=this.lengthInInts;for(let s=Math.floor(e/32);s<i;s++){let i=t?this._data[s]:~this._data[s];if(0!=n)i&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==i)continue;for(let t=0;0!=i;t+=8,i>>>=8){const n=r._firstOnBit[255&i];if(n>=0)return(e=n+32*s+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let i=Math.floor(e/32);i>=0;i--){let e=t?this._data[i]:~this._data[i];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=r._lastOnBit[e>>>24];if(n>=0)return n+32*i+t}}return-1}}r._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),r._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),r._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(e,t,n)=>{"use strict";n.d(t,{Pl:()=>H,bk:()=>B,gM:()=>G,L1:()=>k,cb:()=>Y,E3:()=>L,J6:()=>O,Wj:()=>I,Xk:()=>R,N$:()=>F,t6:()=>N,PE:()=>M,rd:()=>$,Bl:()=>K,CN:()=>b});var r=n(4328),i=n(6082);n(9982);const s=i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,');s.columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var o=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function a(e,t,n,i,s,a,c,l,u=!0){return o(this,void 0,void 0,(function*(){let d=null;if(yield $(i,(n=>o(this,void 0,void 0,(function*(){let n=null;for(const r of e.viewers)r.type===t&&(n=r);if(!n)throw Error("Viewer hasn't been added");if(yield Promise.resolve(),a&&(yield a(n)),s){const t=null!=l?l:{};t.tv=e,t.viewer=n,d=yield s(t,u)}yield M(r.events.onViewerClosed,(()=>{L(n.subs.some((e=>!e.closed)),!1)}),(()=>n.close()),3e3)}))),(()=>o(this,void 0,void 0,(function*(){c?e.loadLayout(c):yield function(e,t,n){return o(this,void 0,void 0,(function*(){let r;return n?(r=yield e.dataFrame.plot.fromType(t),e.dockManager.dock(r)):r=e.addViewer(t),r}))}(e,t,n)}))),6e4,"TEST_EVENT_ASYNC"),d)return d}))}function c(e,t=!0){return o(this,void 0,void 0,(function*(){const n=e.tv.dataFrame,r=n.clone();Array.from(n.row(0).cells).forEach((e=>e.value=null));const i=n.rowCount<20?Math.floor(n.rowCount/2):10;n.rows.select((e=>e.idx>=0&&e.idx<i)),t&&(yield Y(50));for(let e=i;e<2*i;e++)n.filter.set(e,!1);t&&(yield Y(50)),n.currentRowIdx=1,n.columns.names().slice(0,Math.ceil(n.columns.length/2)).forEach((e=>n.columns.remove(e))),t&&(yield Y(100)),e.tv.dataFrame=r,yield Y(50)}))}function l(e,t=!0){return o(this,void 0,void 0,(function*(){const t=e.tv.dataFrame;setTimeout((()=>t.filter.set(0,!t.filter.get(0))),0)}))}function u(e,t=!0){return o(this,void 0,void 0,(function*(){let t,n;try{t=e.viewer.getOptions(!0).look}catch(e){throw new Error("Viewer's .getOptions() error.",{cause:e})}try{n=e.viewer.getProperties()}catch(e){throw new Error("Viewer's .getProperties() error.",{cause:e})}const r={};return Object.keys(t).filter((e=>"boolean"==typeof t[e])).forEach((e=>r[e]=!t[e])),n.filter((e=>null!==e.choices)).forEach((e=>r[e.name]=e.choices.find((n=>n!==t[e.name])))),e.viewer.setOptions(r),yield Y(300),{layout:e.tv.saveLayout(),savedProps:e.viewer.getOptions().look}}))}function d(e,t=!0){return o(this,void 0,void 0,(function*(){L(JSON.stringify(e.viewer.getOptions().look),JSON.stringify(e.savedProps))}))}var h=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};const p=3e4,m=108e5,f=console.log.bind(console),g=console.info.bind(console),y=console.warn.bind(console),w=console.error.bind(console),b={},v="Auto Tests",A="Demo",E="Detectors",C="Core",T={};let S;var _;!function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(_||(_={}));class x{constructor(e,t){this.catchUnhandled=!0,this.report=!1,void 0!==e&&(this.catchUnhandled=e),void 0!==t&&(this.report=t)}}class P{constructor(e,t,n,r){var i;this.category=e,this.name=t,null!=r||(r={}),null!==(i=r.timeout)&&void 0!==i||(r.timeout=p),this.options=r,this.test=()=>h(this,void 0,void 0,(function*(){return new Promise(((e,t)=>h(this,void 0,void 0,(function*(){let r="";try{r=yield n()}catch(e){t(e)}e(r)}))))}))}}function M(e,t,n,r=0,i="timeout"){return h(this,void 0,void 0,(function*(){return new Promise(((s,o)=>{const a=e.subscribe((e=>{try{t(e),s("OK")}catch(e){o(e)}finally{a.unsubscribe(),clearTimeout(c)}})),c=setTimeout((()=>{a.unsubscribe(),o(i)}),r);n()}))}))}function $(e,t,n,r=0,i="timeout"){return h(this,void 0,void 0,(function*(){return new Promise(((s,o)=>{const a=e.subscribe((e=>{t(e).then((()=>{s("OK")})).catch((e=>{o(e)})).finally((()=>{a.unsubscribe(),clearTimeout(c)}))})),c=setTimeout((()=>{a.unsubscribe(),o(i)}),r);n()}))}))}function N(e,t,n){null==b[S]&&(b[S]={}),null==b[S].tests&&(b[S].tests=[]),b[S].tests.push(new P(S,e,t,n))}function L(e,t=!0,n){if(n=n?`${n}, `:"",e!==t)throw new Error(`${n}Expected "${t}", got "${e}"`)}function I(e,t,n=.001,r){if(e===Number.POSITIVE_INFINITY&&t===Number.POSITIVE_INFINITY||e===Number.NEGATIVE_INFINITY&&t===Number.NEGATIVE_INFINITY||e===Number.NaN&&t===Number.NaN||isNaN(e)&&isNaN(t))return;const i=Math.abs(e-t)<n;if(L(i,!0,`${null!=r?r:""} (tolerance = ${n})`),!i)throw new Error(`Expected ${t}, got ${e} (tolerance = ${n})`)}function R(e,t){for(const[n,r]of Object.entries(t)){if(!e.hasOwnProperty(n))throw new Error(`Expected property "${n}" not found`);const t=e[n];if(t instanceof Array&&r instanceof Array)O(t,r);else if(t instanceof Object&&r instanceof Object)R(t,r);else if(Number.isFinite(t)&&Number.isFinite(r))I(t,r);else if(t!=r)throw new Error(`Expected (${r}) for key '${n}', got (${t})`)}}function O(e,t){const n=e.length,r=t.length;if(n!=r)throw new Error(`Arrays are of different length: actual array length is ${n} and expected array length is ${r}`);for(let r=0;r<n;r++)if(e[r]instanceof Array&&t[r]instanceof Array)O(e[r],t[r]);else if(e[r]instanceof Object&&t[r]instanceof Object)R(e[r],t[r]);else if(e[r]!=t[r])throw new Error(`Expected ${t[r]} at position ${r}, got ${e[r]}`)}function k(e,t,n){var r;S=e,t(),b[S]&&(b[S].clear=null===(r=null==n?void 0:n.clear)||void 0===r||r,b[S].timeout=null==n?void 0:n.timeout,b[S].benchmarks=null==n?void 0:n.benchmarks,b[S].stressTests=null==n?void 0:n.stressTests)}function G(e){null==b[S]&&(b[S]={}),b[S].before=e}function H(e){null==b[S]&&(b[S]={}),b[S].after=e}function D(e,t){return e.replace(new RegExp(t.name,"gi"),t.nqName)}function F(e){var t,n,o,a;return h(this,void 0,void 0,(function*(){const c=null===(n=null===(t=r.functions.getCurrentCall())||void 0===t?void 0:t.func)||void 0===n?void 0:n.package;yield function(e){var t,n,o,a;return h(this,void 0,void 0,(function*(){const c=e.id;if(T[c])return;const l=b;if(void 0!==l[v]||void 0!==l[A]||Object.keys(l).find((e=>e.startsWith(v)||e.startsWith(C))))return void(T[c]=!0);if("DevTools"===e.name)for(const e of window.dartTests){const r=e.name.split(/\s*\|\s*!/g);let i=null!==(t=r.pop())&&void 0!==t?t:e.name,s=r.length?C+": "+r.join(": "):C,c=i.split(" | ");i=c[c.length-1],c.unshift(s),c.pop(),s=c.join(": "),void 0===l[s]&&(l[s]={tests:[],clear:!0}),l[s].tests.push(new P(s,i,e.test,{isAggregated:!1,timeout:null!==(o=null===(n=e.options)||void 0===n?void 0:n.timeout)&&void 0!==o?o:p,skipReason:null===(a=e.options)||void 0===a?void 0:a.skipReason}))}const u=[],d=[],m=[],f=yield r.dapi.functions.filter(`package.id = "${c}"`).list(),g=new RegExp(/skip:\s*([^,\s]+)|wait:\s*(\d+)|cat:\s*([^,\s]+)|timeout:\s*(\d+)/g);for(const e of f){const t=e.options.test,n=e.options.demoPath;if(t&&Array.isArray(t)&&t.length)for(let n=0;n<t.length;n++){const s=t[n].matchAll(g),o={};Array.from(s).forEach((e=>{e[0].startsWith("skip")?o.skip=e[1]:e[0].startsWith("wait")?o.wait=parseInt(e[2]):e[0].startsWith("cat")?o.cat=e[3]:e[0].startsWith("timeout")&&(o.timeout=parseInt(e[4]))}));const a=new P(v,1===t.length?e.name:`${e.name} ${n+1}`,(()=>h(this,void 0,void 0,(function*(){const i=yield r.functions.eval(D(t[n],e));if(o.wait&&(yield Y(o.wait)),"boolean"==typeof i&&!i)throw`Failed: ${t[n]}, expected true, got ${i}`}))),{skipReason:o.skip,timeout:i.Test.isInBenchmark?o.benchmarkTimeout:o.timeout});if(o.cat){const e=v+": "+o.cat;a.category=e,void 0===l[e]&&(l[e]={tests:[],clear:!0}),l[e].tests.push(a)}else u.push(a)}if(n){const t=e.options.demoWait?parseInt(e.options.demoWait):void 0,n=new P(A,e.friendlyName,(()=>h(this,void 0,void 0,(function*(){r.shell.isInDemo=!0,void 0===r.shell.view(i.View.BROWSE)&&(r.shell.v=i.View.createByType(i.View.BROWSE)),yield Y(300),r.shell.clearLastError(),yield e.apply(),yield Y(t||2e3);const n=yield r.shell.lastError;if(n)throw new Error(n);r.shell.isInDemo=!1}))),{skipReason:e.options.demoSkip});d.push(n)}if(e.hasTag("semTypeDetector")){const t=new P(E,e.friendlyName,(()=>h(this,void 0,void 0,(function*(){const t=[];for(const n of s.clone().columns){const r=yield e.apply([n]);t.push(r||n.semType)}L(t.filter((e=>e)).length,1)}))),{skipReason:e.options.skipTest});m.push(t)}}T[c]=!0,u.length&&(l[v]={tests:u,clear:!0}),d.length&&(l[A]={tests:d,clear:!0}),m.length&&(l[E]={tests:m,clear:!1})}))}(c);const l=[];console.log("Running tests"),null!=e||(e={}),null!==(o=(a=e).testContext)&&void 0!==o||(a.testContext=new x),r.shell.clearLastError();const u=function(){const e=[];return console.log=(...t)=>{e.push(...t),f(...t)},console.info=(...t)=>{e.push(...t),g(...t)},console.warn=(...t)=>{e.push(...t),y(...t)},console.error=(...t)=>{e.push(...t),w(...t)},e}();(null==e?void 0:e.stressTest)?yield function(e){var t,n,r,s,o,a;return h(this,void 0,void 0,(function*(){let h=[];for(const[e,i]of Object.entries(b)){let e=null===(t=i.tests)||void 0===t?void 0:t.filter((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.stressTest}));i.stressTests&&(e=null===(n=i.tests)||void 0===n?void 0:n.filter((e=>{var t,n;return void 0===(null===(t=e.options)||void 0===t?void 0:t.stressTest)||!0===(null===(n=e.options)||void 0===n?void 0:n.stressTest)})));const o=null===(r=i.tests)||void 0===r?void 0:r.every((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.skipReason}));if(!o)for(let t of null!=e?e:[])null==(null===(s=t.options)||void 0===s?void 0:s.skipReason)&&h.push({test:t,value:i})}h=function(e){const t=e.slice();return t.sort((()=>Math.random()-.5)),t}(h);const p=[];for(let t of h){yield d(t.value.before,null!==(o=e.category)&&void 0!==o?o:"");let n=yield V(t.test,null==e?void 0:e.test,u,i.Test.isInBenchmark?t.value.benchmarkTimeout:t.value.timeout,c.name,e.verbose);n&&p.push(n),console.log(`Test: ${null==N?void 0:N.name}; result: ${n}`),yield d(t.value.after,null!==(a=e.category)&&void 0!==a?a:"")}l.push(...p)}))}(e):yield function(e,t){var n,s,o,a,p,m,b;return h(this,void 0,void 0,(function*(){try{for(const[h,g]of Object.entries(e)){if((null==t?void 0:t.category)&&!h.toLowerCase().startsWith(null==t?void 0:t.category.toLowerCase())||(null===(n=t.exclude)||void 0===n?void 0:n.some((e=>h.startsWith(e)))))continue;f(`Started ${h} category`);const e=null===(s=g.tests)||void 0===s?void 0:s.every((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.skipReason}));e||(g.beforeStatus=yield d(g.before,null!==(o=t.category)&&void 0!==o?o:""));const y=null!==(a=g.tests)&&void 0!==a?a:[],w=[];if(g.clear)for(let e=0;e<y.length;e++){y[e].options&&void 0===(null===(p=y[e].options)||void 0===p?void 0:p.benchmark)&&(y[e].options||(y[e].options={}),y[e].options.benchmark=null!==(m=g.benchmarks)&&void 0!==m&&m);let n=yield V(y[e],null==t?void 0:t.test,u,i.Test.isInBenchmark?g.benchmarkTimeout:g.timeout,c.name,t.verbose);n&&w.push(n),r.shell.closeAll(),i.Balloon.closeAll()}else for(let e=0;e<y.length;e++){let n=yield V(y[e],null==t?void 0:t.test,u,i.Test.isInBenchmark?g.benchmarkTimeout:g.timeout,c.name,t.verbose);n&&w.push(n)}const v=w.filter((e=>"skipped"!=e.result));e||(g.afterStatus=yield d(g.after,null!==(b=t.category)&&void 0!==b?b:"")),g.afterStatus&&v.push({date:(new Date).toISOString(),logs:"",category:h,name:"after",result:g.afterStatus,success:!1,ms:0,skipped:!1}),g.beforeStatus&&v.push({date:(new Date).toISOString(),logs:"",category:h,name:"before",result:g.beforeStatus,success:!1,ms:0,skipped:!1}),l.push(...v)}}finally{console.log=f,console.info=g,console.warn=y,console.error=w}if(t.testContext.catchUnhandled&&!i.Test.isInBenchmark){yield Y(1e3);const e=yield r.shell.lastError,t={logs:"",date:(new Date).toISOString(),category:"Unhandled exceptions",name:"Exception",result:null!=e?e:"",success:!e,ms:0,skipped:!1};l.push(t),t.package=c.name,null!=r.shell.reportTest?yield r.shell.reportTest("package",t):yield fetch(`${r.dapi.root}/log/tests/package`,{method:"POST",headers:{"Content-Type":"application/json"},credentials:"same-origin",body:JSON.stringify(t)})}}))}(b,e);for(let e of l)e.result=e.result.toString().replace(/"/g,"'"),null!=e.logs&&(e.logs=e.logs.toString().replace(/"/g,"'"));return l;function d(e,t){return h(this,void 0,void 0,(function*(){var n=void 0;try{void 0!==e&&(yield W((()=>h(this,void 0,void 0,(function*(){yield e()}))),1e5,`before ${t}: timeout error`))}catch(e){n=yield U(e)}return n}))}}))}function U(e){return h(this,void 0,void 0,(function*(){return`${e.toString()}\n${e.stack?yield i.Logger.translateStackTrace(e.stack):""}`}))}function V(e,t,n,s,o,a){var c,l,u,d,g,y,b,v;return h(this,void 0,void 0,(function*(){let h;n.length=0;let A="package";const E=null!=t&&e.name.toLowerCase()!==t.toLowerCase();let C=(null===(c=e.options)||void 0===c?void 0:c.skipReason)||E,T=E?"skipped":null===(l=e.options)||void 0===l?void 0:l.skipReason;if(i.Test.isInBenchmark&&!(null===(u=e.options)||void 0===u?void 0:u.benchmark))return void f(`SKIPPED: ${e.category} ${e.name} doesnt available in benchmark mode`);C||f(`Started ${e.category} ${e.name}`);const S=Date.now();try{if(C)h={date:(new Date).toISOString(),success:!0,result:T,ms:0,skipped:!0};else{let t=(null===(d=e.options)||void 0===d?void 0:d.timeout)===p&&s?s:null===(g=e.options)||void 0===g?void 0:g.timeout;t=t===p&&i.Test.isInBenchmark?m:t,h={date:(new Date).toISOString(),success:!0,result:null!==(y=yield W(e.test,t))&&void 0!==y?y:"OK",ms:0,skipped:!1}}}catch(e){w(e),h={date:(new Date).toISOString(),success:!1,result:yield U(e),ms:0,skipped:!1}}if((null===(b=e.options)||void 0===b?void 0:b.isAggregated)&&h.result.constructor===i.DataFrame){const e=h.result.col("success");if(e&&(h.success=e.stats.sum===e.length),!a){const e=h.result;e.columns.remove("stack"),e.rows.removeWhere((e=>e.get("success"))),h.result=e}h.result=h.result.toCsv()}if(h.logs=n.join("\n"),h.ms=Date.now()-S,C||f(`Finished ${e.category} ${e.name} for ${h.ms} ms`),h.category=e.category,h.name=e.name,!E){let t={success:h.success,result:h.result,ms:h.ms,skipped:h.skipped,package:o,category:e.category,name:e.name,logs:h.logs};if(h.result.constructor==Object){const e=Object.keys(h.result).reduce(((e,t)=>Object.assign(Object.assign({},e),{["result."+t]:h.result[t]})),{});t=Object.assign(Object.assign({},t),e)}t.result instanceof i.DataFrame&&(t.result=JSON.stringify(null===(v=t.result)||void 0===v?void 0:v.toJson())||""),null!=r.shell.reportTest?yield r.shell.reportTest(A,t):yield fetch(`${r.dapi.root}/log/tests/${A}`,{method:"POST",headers:{"Content-Type":"application/json"},credentials:"same-origin",body:JSON.stringify(t)})}return h}))}function Y(e){return h(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}function B(e,t="Timeout exceeded",n=500,r=50){return h(this,void 0,void 0,(function*(){return new Promise(((i,s)=>{setTimeout((()=>{clearInterval(o),s(new Error(t))}),n);const o=setInterval((()=>{e()&&(clearInterval(o),i())}),r)}))}))}function W(e,t,n="EXECUTION TIMEOUT"){return h(this,void 0,void 0,(function*(){let r=null;const i=new Promise(((e,i)=>{r=setTimeout((()=>{i(n)}),t)}));try{return yield Promise.race([e(),i])}finally{r&&clearTimeout(r)}}))}const j=i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])]);function K(e,t,n){var i;return h(this,void 0,void 0,(function*(){const s=null!==(i=null==n?void 0:n.packageName)&&void 0!==i?i:"";(null==n?void 0:n.detectSemanticTypes)&&(yield r.data.detectSemanticTypes(t));const o=r.shell.addTableView(t);try{yield a(o,e,s,r.events.onViewerAdded),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,void 0,n.awaitViewer)),(null==n?void 0:n.readOnly)||(yield a(o,e,s,r.events.onViewerAdded,c),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,c,n.awaitViewer)));let t=null;t=yield a(o,e,s,r.events.onViewerAdded,u),(null==n?void 0:n.awaitViewer)&&(t=yield a(o,e,s,r.events.onViewerAdded,u,n.awaitViewer)),yield a(o,e,s,r.events.onViewLayoutApplied,d,void 0,null==t?void 0:t.layout,{savedProps:null==t?void 0:t.savedProps}),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewLayoutApplied,d,n.awaitViewer,null==t?void 0:t.layout,{savedProps:null==t?void 0:t.savedProps})),!1!==(null==n?void 0:n.arbitraryDfTest)&&(o.dataFrame=j,yield Y(50),yield a(o,e,s,r.events.onViewerAdded),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,void 0,n.awaitViewer))),yield a(o,e,s,r.events.onViewerAdded,l),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,l,n.awaitViewer))}finally{}}))}},3629:(e,t,n)=>{"use strict";function r(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function i(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function s(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let r=0;r<e.length;r++)n+=e[r]*t[r];return n}function o(e,t){let n=0;const r=e.length;if(r!==t.length)throw new Error("The dimensionality of the vectors must match");for(let i=0;i<r;++i)n+=Math.pow(e[i]-t[i],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,r=0;for(let i=0;i<t;++i)n+=e[i],r+=Math.pow(e[i],2);const i=n/t,s=1/Math.sqrt(r/t-Math.pow(i,2));for(let n=0;n<t;++n)e[n]=(e[n]-i)*s;return e}n.d(t,{KE:()=>s,S8:()=>a,ou:()=>o,vA:()=>r,wQ:()=>i})},1913:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3282),i=n(9029),s=n(1520),o=n(2586),a=n(8708),c=n(2023),l="errorMessage",u=new r.Name("emUsed"),d={required:"missingProperty",dependencies:"property",dependentRequired:"property"},h=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:l,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:w}=t;if(!1===w.createErrors)return;const b=g,v=i.strConcat(c.default.instancePath,w.errorPath);function A(e,t){return i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,r._`${e}.instancePath === ${v}`,r._`${e}.keyword in ${t}`,r._`${e}.schemaPath.indexOf(${w.errSchemaPath}) === 0`,r._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${w.errSchemaPath.length}))`)}function E(e,t){const r=[];for(const n in e){const e=t[n];h.test(e)&&r.push([n,T(e)])}return n.object(...r)}function C(e){return h.test(e)?new s._Code(s.safeStringify(e).replace(p,((e,t)=>`" + JSON.stringify(${o.getData(t,w)}) + "`)).replace(m,"")):r.stringify(e)}function T(e){return r._`function(){return ${C(e)}}`}n.if(r._`${c.default.errors} > 0`,(()=>{if("object"==typeof b){const[s,o]=function(e){let t,n;for(const r in e){if("properties"===r||"items"===r)continue;const i=e[r];if("object"==typeof i){t||(t={});const e=t[r]={};for(const t in i)e[t]=[]}else n||(n={}),n[r]=[]}return[t,n]}(b);o&&function(i){const s=n.const("emErrors",r.stringify(i)),o=n.const("templates",E(i,g));n.forOf("err",c.default.vErrors,(e=>n.if(A(e,s),(()=>n.code(r._`${s}[${e}.keyword].push(${e})`).assign(r._`${e}.${u}`,!0)))));const{singleError:l}=e;if(l){const e=n.let("message",r._`""`),i=n.let("paramsErrors",r._`[]`);d((t=>{n.if(e,(()=>n.code(r._`${e} += ${"string"==typeof l?l:";"}`))),n.code(r._`${e} += ${h(t)}`),n.assign(i,r._`${i}.concat(${s}[${t}])`)})),a.reportError(t,{message:e,params:r._`{errors: ${i}}`})}else d((e=>a.reportError(t,{message:h(e),params:r._`{errors: ${s}[${e}]}`})));function d(e){n.forIn("key",s,(t=>n.if(r._`${s}[${t}].length`,(()=>e(t)))))}function h(e){return r._`${e} in ${o} ? ${o}[${e}]() : ${y}[${e}]`}}(o),s&&function(e){const i=n.const("emErrors",r.stringify(e)),s=[];for(const t in e)s.push([t,E(e[t],g[t])]);const o=n.const("templates",n.object(...s)),l=n.scopeValue("obj",{ref:d,code:r.stringify(d)}),h=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",c.default.vErrors,(e=>n.if(A(e,i),(()=>{n.assign(h,r._`${l}[${e}.keyword]`),n.assign(p,r._`${i}[${e}.keyword][${e}.params[${h}]]`),n.if(p,(()=>n.code(r._`${p}.push(${e})`).assign(r._`${e}.${u}`,!0)))})))),n.forIn("key",i,(e=>n.forIn("keyProp",r._`${i}[${e}]`,(s=>{n.assign(p,r._`${i}[${e}][${s}]`),n.if(r._`${p}.length`,(()=>{const i=n.const("tmpl",r._`${o}[${e}] && ${o}[${e}][${s}]`);a.reportError(t,{message:r._`${i} ? ${i}() : ${y}[${e}][${s}]`,params:r._`{errors: ${p}}`})}))}))))}(s),function(e){const{props:s,items:o}=e;if(!s&&!o)return;const d=r._`typeof ${f} == "object"`,h=r._`Array.isArray(${f})`,p=n.let("emErrors");let m,w;const b=n.let("templates");function A(e,t){n.assign(p,r.stringify(e)),n.assign(b,E(e,t))}s&&o?(m=n.let("emChildKwd"),n.if(d),n.if(h,(()=>{A(o,g.items),n.assign(m,r.str`items`)}),(()=>{A(s,g.properties),n.assign(m,r.str`properties`)})),w=r._`[${m}]`):o?(n.if(h),A(o,g.items),w=r._`.items`):s&&(n.if(i.and(d,i.not(h))),A(s,g.properties),w=r._`.properties`),n.forOf("err",c.default.vErrors,(e=>function(e,t,s){n.if(i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,r._`${e}.instancePath.indexOf(${v}) === 0`),(()=>{const i=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:r._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),o=n.const("emMatches",r._`${i}.exec(${e}.instancePath.slice(${v}.length))`),a=n.const("emChild",r._`${o} && ${o}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(r._`${a} !== undefined && ${a} in ${t}`,(()=>s(a)))}))}(e,p,(t=>n.code(r._`${p}[${t}].push(${e})`).assign(r._`${e}.${u}`,!0))))),n.forIn("key",p,(e=>n.if(r._`${p}[${e}].length`,(()=>{a.reportError(t,{message:r._`${e} in ${b} ? ${b}[${e}]() : ${y}${w}[${e}]`,params:r._`{errors: ${p}[${e}]}`}),n.assign(r._`${c.default.vErrors}[${c.default.errors}-1].instancePath`,r._`${v} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(b))}const s="string"==typeof b?b:b._;s&&function(e){const s=n.const("emErrs",r._`[]`);n.forOf("err",c.default.vErrors,(e=>n.if(function(e){return i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,i.or(r._`${e}.instancePath === ${v}`,i.and(r._`${e}.instancePath.indexOf(${v}) === 0`,r._`${e}.instancePath[${v}.length] === "/"`)),r._`${e}.schemaPath.indexOf(${w.errSchemaPath}) === 0`,r._`${e}.schemaPath[${w.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(r._`${s}.push(${e})`).assign(r._`${e}.${u}`,!0))))),n.if(r._`${s}.length`,(()=>a.reportError(t,{message:C(e),params:r._`{errors: ${s}}`})))}(s),e.keepErrors||function(){const e=n.const("emErrs",r._`[]`);n.forOf("err",c.default.vErrors,(t=>n.if(r._`!${t}.${u}`,(()=>n.code(r._`${e}.push(${t})`))))),n.assign(c.default.vErrors,e).assign(c.default.errors,r._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},7433:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv2020=void 0;const r=n(4042),i=n(6105),s=n(6653),o=n(9572),a="https://json-schema.org/draft/2020-12/schema";class c extends r.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),i.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(s.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(o.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}t.Ajv2020=c,e.exports=t=c,e.exports.Ajv2020=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var l=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return l.KeywordCxt}});var u=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var d=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var h=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return h.default}})},3282:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv=void 0;const r=n(4042),i=n(6144),s=n(6653),o=n(2079),a=["/properties"],c="http://json-schema.org/draft-07/schema";class l extends r.default{_addVocabularies(){super._addVocabularies(),i.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(s.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(o,a):o;this.addMetaSchema(e,c,!1),this.refs["http://json-schema.org/schema"]=c}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(c)?c:void 0)}}t.Ajv=l,e.exports=t=l,e.exports.Ajv=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var u=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var d=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return d._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return d.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return d.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return d.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return d.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return d.CodeGen}});var h=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var p=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class r extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=r;class i extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof r&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function s(e,...t){const n=[e[0]];let r=0;for(;r<t.length;)c(n,t[r]),n.push(e[++r]);return new i(n)}t._Code=i,t.nil=new i(""),t._=s;const o=new i("+");function a(e,...t){const n=[u(e[0])];let r=0;for(;r<t.length;)n.push(o),c(n,t[r]),n.push(o,u(e[++r]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===o){const n=l(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new i(n)}function c(e,t){var n;t instanceof i?e.push(...t._items):t instanceof r?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function l(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof r||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof r?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=c,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new i(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new i(`.${e}`):s`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new i(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new i(e.toString())}},9029:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const r=n(1520),i=n(7845);var s=n(1520);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return s._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return s.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return s.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return s.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return s.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return s.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return s.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return s.Name}});var o=n(7845);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return o.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return o.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return o.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return o.varKinds}}),t.operators={GT:new r._Code(">"),GTE:new r._Code(">="),LT:new r._Code("<"),LTE:new r._Code("<="),EQ:new r._Code("==="),NEQ:new r._Code("!=="),NOT:new r._Code("!"),OR:new r._Code("||"),AND:new r._Code("&&"),ADD:new r._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class c extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?i.varKinds.var:this.varKind,r=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${r};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof r._CodeOrName?this.rhs.names:{}}}class l extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof r.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return $(this.lhs instanceof r.Name?{}:{...this.lhs.names},this.rhs)}}class u extends l{constructor(e,t,n,r){super(e,n,r),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class p extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class m extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof r._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let r=n.length;for(;r--;){const i=n[r];i.optimizeNames(e,t)||(L(e,i.names),n.splice(r,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>M(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class w extends g{}w.kind="else";class b extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new w(e):e}return t?!1===e?t instanceof b?t:t.nodes:this.nodes.length?this:new b(I(e),t instanceof b?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return $(e,this.condition),this.else&&M(e,this.else.names),e}}b.kind="if";class v extends g{}v.kind="for";class A extends v{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return M(super.names,this.iteration.names)}}class E extends v{constructor(e,t,n,r){super(),this.varKind=e,this.name=t,this.from=n,this.to=r}render(e){const t=e.es5?i.varKinds.var:this.varKind,{name:n,from:r,to:s}=this;return`for(${t} ${n}=${r}; ${n}<${s}; ${n}++)`+super.render(e)}get names(){const e=$(super.names,this.from);return $(e,this.to)}}class C extends v{constructor(e,t,n,r){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=r}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return M(super.names,this.iterable.names)}}class T extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}T.kind="func";class S extends f{render(e){return"return "+super.render(e)}}S.kind="return";class _ extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,r;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(r=this.finally)||void 0===r||r.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&M(e,this.catch.names),this.finally&&M(e,this.finally.names),e}}class x extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}x.kind="catch";class P extends g{render(e){return"finally"+super.render(e)}}function M(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function $(e,t){return t instanceof r._CodeOrName?M(e,t.names):e}function N(e,t,n){return e instanceof r.Name?s(e):(i=e)instanceof r._Code&&i._items.some((e=>e instanceof r.Name&&1===t[e.str]&&void 0!==n[e.str]))?new r._Code(e._items.reduce(((e,t)=>(t instanceof r.Name&&(t=s(t)),t instanceof r._Code?e.push(...t._items):e.push(t),e)),[])):e;var i;function s(e){const r=n[e.str];return void 0===r||1!==t[e.str]?e:(delete t[e.str],r)}}function L(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function I(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:r._`!${G(e)}`}P.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new i.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,r){const i=this._scope.toName(t);return void 0!==n&&r&&(this._constants[i.str]=n),this._leafNode(new c(e,i,n)),i}const(e,t,n){return this._def(i.varKinds.const,e,t,n)}let(e,t,n){return this._def(i.varKinds.let,e,t,n)}var(e,t,n){return this._def(i.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new l(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==r.nil&&this._leafNode(new m(e)),this}object(...e){const t=["{"];for(const[n,i]of e)t.length>1&&t.push(","),t.push(n),(n!==i||this.opts.es5)&&(t.push(":"),(0,r.addCodeArg)(t,i));return t.push("}"),new r._Code(t)}if(e,t,n){if(this._blockNode(new b(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new b(e))}else(){return this._elseNode(new w)}endIf(){return this._endBlockNode(b,w)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new A(e),t)}forRange(e,t,n,r,s=(this.opts.es5?i.varKinds.var:i.varKinds.let)){const o=this._scope.toName(e);return this._for(new E(s,o,t,n),(()=>r(o)))}forOf(e,t,n,s=i.varKinds.const){const o=this._scope.toName(e);if(this.opts.es5){const e=t instanceof r.Name?t:this.var("_arr",t);return this.forRange("_i",0,r._`${e}.length`,(t=>{this.var(o,r._`${e}[${t}]`),n(o)}))}return this._for(new C("of",s,o,t),(()=>n(o)))}forIn(e,t,n,s=(this.opts.es5?i.varKinds.var:i.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,r._`Object.keys(${t})`,n);const o=this._scope.toName(e);return this._for(new C("in",s,o,t),(()=>n(o)))}endFor(){return this._endBlockNode(v)}label(e){return this._leafNode(new d(e))}break(e){return this._leafNode(new h(e))}return(e){const t=new S;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(S)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const r=new _;if(this._blockNode(r),this.code(e),t){const e=this.name("e");this._currNode=r.catch=new x(e),t(e)}return n&&(this._currNode=r.finally=new P,this.code(n)),this._endBlockNode(x,P)}throw(e){return this._leafNode(new p(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=r.nil,n,i){return this._blockNode(new T(e,t,n)),i&&this.code(i).endFunc(),this}endFunc(){return this._endBlockNode(T)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof b))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=I;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===r.nil?n:n===r.nil?t:r._`${G(t)} ${e} ${G(n)}`}function G(e){return e instanceof r.Name?e:r._`(${e})`}t.or=function(...e){return e.reduce(O)}},7845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const r=n(1520);class i extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var s;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(s||(t.UsedValueState=s={})),t.varKinds={const:new r.Name("const"),let:new r.Name("let"),var:new r.Name("var")};class o{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof r.Name?e:this.name(e)}name(e){return new r.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=o;class a extends r.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=r._`.${new r.Name(t)}[${n}]`}}t.ValueScopeName=a;const c=r._`\n`;t.ValueScope=class extends o{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?c:r.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const r=this.toName(e),{prefix:i}=r,s=null!==(n=t.key)&&void 0!==n?n:t.ref;let o=this._values[i];if(o){const e=o.get(s);if(e)return e}else o=this._values[i]=new Map;o.set(s,r);const a=this._scope[i]||(this._scope[i]=[]),c=a.length;return a[c]=t.ref,r.setValue(t,{property:i,itemIndex:c}),r}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return r._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,o={},a){let c=r.nil;for(const l in e){const u=e[l];if(!u)continue;const d=o[l]=o[l]||new Map;u.forEach((e=>{if(d.has(e))return;d.set(e,s.Started);let o=n(e);if(o){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;c=r._`${c}${n} ${e} = ${o};${this.opts._n}`}else{if(!(o=null==a?void 0:a(e)))throw new i(e);c=r._`${c}${o}${this.opts._n}`}d.set(e,s.Completed)}))}return c}}},8708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const r=n(9029),i=n(4227),s=n(2023);function o(e,t){const n=e.const("err",t);e.if(r._`${s.default.vErrors} === null`,(()=>e.assign(s.default.vErrors,r._`[${n}]`)),r._`${s.default.vErrors}.push(${n})`),e.code(r._`${s.default.errors}++`)}function a(e,t){const{gen:n,validateName:i,schemaEnv:s}=e;s.$async?n.throw(r._`new ${e.ValidationError}(${t})`):(n.assign(r._`${i}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>r.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?r.str`"${e}" keyword must be ${t} ($data)`:r.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,i,s){const{it:c}=e,{gen:u,compositeRule:d,allErrors:h}=c,p=l(e,n,i);(null!=s?s:d||h)?o(u,p):a(c,r._`[${p}]`)},t.reportExtraError=function(e,n=t.keywordError,r){const{it:i}=e,{gen:c,compositeRule:u,allErrors:d}=i;o(c,l(e,n,r)),u||d||a(i,s.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(s.default.errors,t),e.if(r._`${s.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(r._`${s.default.vErrors}.length`,t)),(()=>e.assign(s.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:i,errsCount:o,it:a}){if(void 0===o)throw new Error("ajv implementation error");const c=e.name("err");e.forRange("i",o,s.default.errors,(o=>{e.const(c,r._`${s.default.vErrors}[${o}]`),e.if(r._`${c}.instancePath === undefined`,(()=>e.assign(r._`${c}.instancePath`,(0,r.strConcat)(s.default.instancePath,a.errorPath)))),e.assign(r._`${c}.schemaPath`,r.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(r._`${c}.schema`,n),e.assign(r._`${c}.data`,i))}))};const c={keyword:new r.Name("keyword"),schemaPath:new r.Name("schemaPath"),params:new r.Name("params"),propertyName:new r.Name("propertyName"),message:new r.Name("message"),schema:new r.Name("schema"),parentSchema:new r.Name("parentSchema")};function l(e,t,n){const{createErrors:i}=e.it;return!1===i?r._`{}`:function(e,t,n={}){const{gen:i,it:o}=e,a=[u(o,n),d(e,n)];return function(e,{params:t,message:n},i){const{keyword:o,data:a,schemaValue:l,it:u}=e,{opts:d,propertyName:h,topSchemaRef:p,schemaPath:m}=u;i.push([c.keyword,o],[c.params,"function"==typeof t?t(e):t||r._`{}`]),d.messages&&i.push([c.message,"function"==typeof n?n(e):n]),d.verbose&&i.push([c.schema,l],[c.parentSchema,r._`${p}${m}`],[s.default.data,a]),h&&i.push([c.propertyName,h])}(e,t,a),i.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?r.str`${e}${(0,i.getErrorPath)(t,i.Type.Str)}`:e;return[s.default.instancePath,(0,r.strConcat)(s.default.instancePath,n)]}function d({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:s}){let o=s?t:r.str`${t}/${e}`;return n&&(o=r.str`${o}${(0,i.getErrorPath)(n,i.Type.Str)}`),[c.schemaPath,o]}},3835:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const r=n(9029),i=n(3558),s=n(2023),o=n(6939),a=n(4227),c=n(2586);class l{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,o.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=h.call(this,e);if(t)return t;const n=(0,o.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:l}=this.opts.code,{ownProperties:u}=this.opts,d=new r.CodeGen(this.scope,{es5:a,lines:l,ownProperties:u});let p;e.$async&&(p=d.scopeValue("Error",{ref:i.default,code:r._`require("ajv/dist/runtime/validation_error").default`}));const m=d.scopeName("validate");e.validateName=m;const f={gen:d,allErrors:this.opts.allErrors,data:s.default.data,parentData:s.default.parentData,parentDataProperty:s.default.parentDataProperty,dataNames:[s.default.data],dataPathArr:[r.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:d.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,r.stringify)(e.schema)}:{ref:e.schema}),validateName:m,ValidationError:p,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:r.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:r._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,c.validateFunctionCode)(f),d.optimize(this.opts.code.optimize);const t=d.toString();g=`${d.scopeRefs(s.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${s.default.self}`,`${s.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:t,scopeValues:d._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof r.Name?void 0:e,items:t instanceof r.Name?void 0:t,dynamicProps:e instanceof r.Name,dynamicItems:t instanceof r.Name},n.source&&(n.source.evaluated=(0,r.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function d(e){return(0,o.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function h(e){for(const r of this._compilations)if(n=e,(t=r).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return r;var t,n}function p(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||m.call(this,e,t)}function m(e,t){const n=this.opts.uriResolver.parse(t),r=(0,o._getFullPath)(this.opts.uriResolver,n);let i=(0,o.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&r===i)return g.call(this,n,e);const s=(0,o.normalizeId)(r),a=this.refs[s]||this.schemas[s];if("string"==typeof a){const t=m.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),s===(0,o.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,r=t[n];return r&&(i=(0,o.resolveUrl)(this.opts.uriResolver,i,r)),new l({schema:t,schemaId:n,root:e,baseId:i})}return g.call(this,n,a)}}t.SchemaEnv=l,t.compileSchema=u,t.resolveRef=function(e,t,n){var r;n=(0,o.resolveUrl)(this.opts.uriResolver,t,n);const i=e.refs[n];if(i)return i;let s=p.call(this,e,n);if(void 0===s){const i=null===(r=e.localRefs)||void 0===r?void 0:r[n],{schemaId:o}=this.opts;i&&(s=new l({schema:i,schemaId:o,root:e,baseId:t}))}return void 0!==s?e.refs[n]=d.call(this,s):void 0},t.getCompilingSchema=h,t.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:r}){var i;if("/"!==(null===(i=e.fragment)||void 0===i?void 0:i[0]))return;for(const r of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(r)];if(void 0===e)return;const i="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(r)&&i&&(t=(0,o.resolveUrl)(this.opts.uriResolver,t,i))}let s;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,o.resolveUrl)(this.opts.uriResolver,t,n.$ref);s=m.call(this,r,e)}const{schemaId:c}=this.opts;return s=s||new l({schema:n,schemaId:c,root:r,baseId:t}),s.schema!==s.root.schema?s:void 0}},2023:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={data:new r.Name("data"),valCxt:new r.Name("valCxt"),instancePath:new r.Name("instancePath"),parentData:new r.Name("parentData"),parentDataProperty:new r.Name("parentDataProperty"),rootData:new r.Name("rootData"),dynamicAnchors:new r.Name("dynamicAnchors"),vErrors:new r.Name("vErrors"),errors:new r.Name("errors"),this:new r.Name("this"),self:new r.Name("self"),scope:new r.Name("scope"),json:new r.Name("json"),jsonPos:new r.Name("jsonPos"),jsonLen:new r.Name("jsonLen"),jsonPart:new r.Name("jsonPart")};t.default=i},4551:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(6939);class i extends Error{constructor(e,t,n,i){super(i||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,r.resolveUrl)(e,t,n),this.missingSchema=(0,r.normalizeId)((0,r.getFullPath)(e,this.missingRef))}}t.default=i},6939:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const r=n(4227),i=n(2017),s=n(7106),o=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!c(e):!!t&&l(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function c(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(c))return!0;if("object"==typeof n&&c(n))return!0}return!1}function l(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!o.has(n)&&("object"==typeof e[n]&&(0,r.eachItem)(e[n],(e=>t+=l(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=p(t));const r=e.parse(t);return d(e,r)}function d(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=d;const h=/#\/?$/;function p(e){return e?e.replace(h,""):""}t.normalizeId=p,t.resolveUrl=function(e,t,n){return n=p(n),e.resolve(t,n)};const m=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:r}=this.opts,o=p(e[n]||t),a={"":o},c=u(r,o,!1),l={},d=new Set;return s(e,{allKeys:!0},((e,t,r,i)=>{if(void 0===i)return;const s=c+t;let o=a[i];function u(t){const n=this.opts.uriResolver.resolve;if(t=p(o?n(o,t):t),d.has(t))throw f(t);d.add(t);let r=this.refs[t];return"string"==typeof r&&(r=this.refs[r]),"object"==typeof r?h(e,r.schema,t):t!==p(s)&&("#"===t[0]?(h(e,l[t],t),l[t]=e):this.refs[t]=s),t}function g(e){if("string"==typeof e){if(!m.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(o=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=o})),l;function h(e,t,n){if(void 0!==t&&!i(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},396:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},4227:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const r=n(9029),i=n(1520);function s(e,t=e.schema){const{opts:n,self:r}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const i=r.RULES.keywords;for(const n in t)i[n]||m(e,`unknown keyword: "${n}"`)}function o(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function c(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function l({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:i}){return(s,o,a,c)=>{const l=void 0===a?o:a instanceof r.Name?(o instanceof r.Name?e(s,o,a):t(s,o,a),a):o instanceof r.Name?(t(s,a,o),o):n(o,a);return c!==r.Name||l instanceof r.Name?l:i(s,l)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",r._`{}`);return void 0!==t&&d(e,n,t),n}function d(e,t,n){Object.keys(n).forEach((n=>e.assign(r._`${t}${(0,r.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(s(e,t),!o(t,e.self.RULES.all))},t.checkUnknownRules=s,t.schemaHasRules=o,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,i,s){if(!s){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return r._`${n}`}return r._`${e}${t}${(0,r.getProperty)(i)}`},t.unescapeFragment=function(e){return c(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=c,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:l({mergeNames:(e,t,n)=>e.if(r._`${n} !== true && ${t} !== undefined`,(()=>{e.if(r._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,r._`${n} || {}`).code(r._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(r._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,r._`${n} || {}`),d(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:l({mergeNames:(e,t,n)=>e.if(r._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,r._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(r._`${n} !== true`,(()=>e.assign(n,!0===t||r._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=d;const h={};var p;function m(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:h[t.code]||(h[t.code]=new i._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(p||(t.Type=p={})),t.getErrorPath=function(e,t,n){if(e instanceof r.Name){const i=t===p.Num;return n?i?r._`"[" + ${e} + "]"`:r._`"['" + ${e} + "']"`:i?r._`"/" + ${e}`:r._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,r.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=m},7887:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>r(e,t)))}function r(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},r){const i=t.RULES.types[r];return i&&!0!==i&&n(e,i)},t.shouldUseGroup=n,t.shouldUseRule=r},8727:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const r=n(8708),i=n(9029),s=n(2023),o={message:"boolean schema is false"};function a(e,t){const{gen:n,data:i}=e,s={gen:n,keyword:"false schema",data:i,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,r.reportError)(s,o,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:r}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(s.default.data):(t.assign(i._`${r}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:r}=e;!1===r?(n.var(t,!1),a(e)):n.var(t,!0)}},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const r=n(396),i=n(7887),s=n(8708),o=n(9029),a=n(4227);var c;function l(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(r.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(c||(t.DataType=c={})),t.getSchemaTypes=function(e){const t=l(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=l,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:r,opts:s}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,s.coerceTypes),l=t.length>0&&!(0===a.length&&1===t.length&&(0,i.schemaHasRulesForType)(e,t[0]));if(l){const i=h(t,r,s.strictNumbers,c.Wrong);n.if(i,(()=>{a.length?function(e,t,n){const{gen:r,data:i,opts:s}=e,a=r.let("dataType",o._`typeof ${i}`),c=r.let("coerced",o._`undefined`);"array"===s.coerceTypes&&r.if(o._`${a} == 'object' && Array.isArray(${i}) && ${i}.length == 1`,(()=>r.assign(i,o._`${i}[0]`).assign(a,o._`typeof ${i}`).if(h(t,i,s.strictNumbers),(()=>r.assign(c,i))))),r.if(o._`${c} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===s.coerceTypes)&&l(e);function l(e){switch(e){case"string":return void r.elseIf(o._`${a} == "number" || ${a} == "boolean"`).assign(c,o._`"" + ${i}`).elseIf(o._`${i} === null`).assign(c,o._`""`);case"number":return void r.elseIf(o._`${a} == "boolean" || ${i} === null
1
+ var bio_test;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>i});var r=n(7362);class i extends r.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in i.aaSynonyms?i.aaSynonyms[e]:e;return super.get(t)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class s{static getPalette(e="grok"){switch(e){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",r="";for(const i of e)"("==i?t++:")"==i?t--:t?n+=i:r+=i;return isNaN(parseInt(n))?[r,n]:[r,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[r,i]=this.getInnerOuter(e);if(r=r.length>6?`${r.slice(0,3)}...`:r,i=i.length>6?`${i.slice(0,3)}...`:i,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,i,1]:[this.undefinedColor,r,i,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,i,2]:[this.undefinedColor,r,i,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,i,3]:[this.undefinedColor,r,i,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,i,4]:[this.undefinedColor,r,i,4]}return[this.undefinedColor,r,i,0]}}s.SemType="Aminoacids",s.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",s.undefinedColor="rgb(100,100,100)",s.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},s.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},s.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},s.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>i});var r=n(6082);async function i(){const e=r.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},9124:(e,t,n)=>{"use strict";n.d(t,{b:()=>s});var r=n(7389),i=n(6082);async function s(){const e="Helm",t=i.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}i.JsInputBase,r.input.helmAsync=async function(e,t){return(await s()).createHelmInput(e,t)}},4356:(e,t,n)=>{"use strict";n.d(t,{Es:()=>a,Eu:()=>u,so:()=>s,ub:()=>l,yZ:()=>d});var r=n(4328);const i="Libraries",s="System:AppData/Bio/monomer-libraries/",o={explicit:["HELMCoreLibrary.json","polytool-lib.json"],exclude:[],duplicateMonomerPreferences:{}},a="System:AppData/Bio/monomer-sets/";let c=Promise.resolve();async function l(){let e;return c=c.then((async()=>{const t=await r.dapi.userDataStorage.getValue(i,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await c,e}async function u(e){c=c.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await r.dapi.userDataStorage.postValue(i,"Settings",JSON.stringify(e),!0)})),await c}async function d(){await u(o)}},6718:(e,t,n)=>{"use strict";n.d(t,{A7:()=>d,pj:()=>c,uL:()=>l});var r=n(6082),i=n(4328),s=n(6295),o=(n(3151),n(2738)),a=(n(826),n(3077));async function c(){const e=r.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function l(e,t){e instanceof r.Column&&(e=(0,a.R)(e).columns.toList());const n=(await c()).getMonomerLib(),s=new Array(e.length),l=e[0].length,u=new Float32Array(l);for(let a=0;a<e.length;++a){const c=a<t.length?t.getCanonical(a):o._S,d=n.getMonomer("PEPTIDE",c)?.smiles??"",h=e[a],p=h.getRawData(),m=h.categories,f=m.indexOf("");if(s[a]={categories:m,data:p,emptyIndex:f},void 0===c)continue;const g=r.Column.fromStrings("smiles",m.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(r.DataFrame.fromColumns([g]),await i.chem.getSimilarities(g,d)),w=y?y.getRawData():null;for(let e=0;e<l;++e){const t=p[e];c!==o._S&&t!==f?u[e]+=w[t]:c===o._S&&t===f&&(u[e]+=1)}}for(let n=0;n<u.length;++n){let i=u[n]/t.length;for(let o=0;o<e.length;++o){const e=s[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){i=r.FLOAT_NULL;break}}u[n]=i}return r.Column.fromFloat32Array("Similarity",u)}async function u(e){const t=(await c()).getMonomerLib(),n=[],s={},o=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=r.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){s[e[t]]=t;const r=o[t],c=""===r?new Array(o.length).fill(0):(await i.chem.getSimilarities(a,r)).getRawData();c[t]=1,n[t]=Array.from(c)}return{scoringMatrix:n,alphabetIndexes:s}}async function d(e,t="Morgan"){const n=(await c()).getMonomerLib(),i=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),o={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||"")),l=r.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await u(e);const d=r.Column.fromStrings("smiles",a),h=(r.DataFrame.fromColumns([d]),(await l.apply({col:d,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await u(e);for(let t=0;t<h.length;++t)if(i[t][t]=1,o[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(i[t][e]=i[e][t]=(0,s.$1)(h[t],h[e]));return{scoringMatrix:i,alphabetIndexes:o}}},7384:(e,t,n)=>{"use strict";n.d(t,{C4:()=>h});var r=n(4328),i=n(6082),s=n(1991),o=n.n(s),a=n(439),c=n(826);const l={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(3151);function d(e){return Math.round(l.PRECISION_FACTOR*e)/l.PRECISION_FACTOR}async function h(e,t,s){if(0===i.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==i.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${i.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let d=t;const h=c.GO.forColumn(t);h.isHelm()&&(d=h.convert(a.Hi.SEPARATOR,"."),d.name=t.name);const m=c.GO.forColumn(d).alphabet;let f;if(m===a.YI.PT||m===a.YI.UN)f="PEPTIDE";else{if(m!==a.YI.RNA&&m!==a.YI.DNA)return{col:null,warnings:[`Unexpected column's '${d.name}' alphabet '${m}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),i=c.GO.forColumn(e);let s=!1;for(let e=0;e<t;++e){const t=i.getSplitted(e);s||(s=0===t.length),n[e]=o()(t.canonicals).filter((e=>!i.isGap(e))).map((e=>e)).toArray()}return s&&r.shell.warning(`Some values in the "${e.name}" column are empty`),n}(d),y=await async function(e,t,n,i){const s=function(e,t,n){const r=new Map;for(const i of e.getMonomerSymbolsByType(t)){const s=e.getMonomer(t,i);if("RNA"===t&&("Branch"===s.monomerType||n===a.YI.DNA&&s.symbol===l.DEOXYRIBOSE||n===a.YI.RNA&&s.symbol===l.RIBOSE||s.symbol===l.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==s.monomerType){const e={};u.f6.forEach((t=>{e[t]=s[t]})),r.set(s.symbol,e)}}return r}(t,n,i),o=new Map,c=await r.functions.call("Chem:getRdKitModule"),d={value:null};if("RNA"===n){const e=i===a.YI.RNA?[l.RIBOSE,l.PHOSPHATE]:[l.DEOXYRIBOSE,l.PHOSPHATE];for(const t of e)p(o,t,s,c,n,d)}for(let t=0;t<e.length;++t){const r=e[t];for(const e of r)if(""!==e)try{p(o,e,s,c,n,d)}catch(t){const n=t instanceof Error?t.message:t.toString(),r=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${r}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return o}(g,s,f,m),w=d.length,{molfileList:b,molfileWarningList:v}=await async function(e,t,r,i,s){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(n.p+n.u(248),n.b)))),c=s/o;let l=[],u=[];const d=new Array(o);for(let n=0;n<o;n++){const l=Math.floor(n*c),u=n===o-1?s:Math.floor((n+1)*c);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:r,polymerType:i,start:l,end:u}),d[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(d)).forEach((e=>{l=l.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:l,molfileWarningList:u}}(g,y,m,f,w);if(v.length>.05*w)throw new Error("Too many errors getting molfiles.");const A=`molfile(${d.name})`,E=e.columns.getUnusedName(A),C=i.Column.fromStrings(E,b);return C.semType=i.SEMTYPE.MOLECULE,C.meta.units=i.UNITS.Molecule.MOLBLOCK,{col:C,warnings:v}}function p(e,t,n,r,i,s){if(!e.has(t)){const o=function(e,t,n,r,i){if(t.has(e)){const o=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(o.rgroups),c=(s=o.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let r;for(;null!==(r=n.exec(e));)r.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(r[1]),parseInt(r[3]));return t}(s):function(e){const t=new Map;let n=e.indexOf(l.V2K_A_LINE,0),r=n;for(;-1!==n;){r=e.indexOf("\n",n);const i=parseInt(e.substring(n,r).replace(/^A\s+/,""));n=e.indexOf("R",r),r=e.indexOf("\n",n);const s=parseInt(e.substring(n,r).replace(/^R/,""));t.set(i,s),n=e.indexOf(l.V2K_A_LINE,r)}for(n=e.indexOf(l.V2K_RGP_LINE,0),r=e.indexOf("\n",n);-1!==n;){n+=l.V2K_RGP_SHIFT,r=e.indexOf("\n",n);const i=e.substring(n,r).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<i.length;e+=2){if(t.has(i[e])&&t.get(i[e])!==i[e+1])throw new Error(`r-group index ${i[e]} has already been added with a different value`);t.set(i[e],i[e+1])}n=e.indexOf(l.V2K_RGP_LINE,r)}return t}(s),u=o.molfile.includes("V3000")?o.molfile:function(e,t){const n=t.get_mol(e),r=n.get_v3Kmolblock();return n.delete(),r}(function(e){let t=e.indexOf(l.V2K_A_LINE,0);-1===t&&(t=e.indexOf(l.V2K_RGP_LINE));const n=e.indexOf(l.V3K_END,t);return e.substring(0,t)+e.substring(n)}(o.molfile),n),h=function(e){let t=(e=e.replaceAll("\r","")).indexOf(l.V3K_BEGIN_COUNTS_LINE)+l.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const r=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:r,bondCount:parseInt(e.substring(t,n))}}(u),p=function(e,t){const n=new Array(t),r=new Float32Array(t),i=new Float32Array(t),s=new Array(t);let o=e.indexOf(l.V3K_BEGIN_ATOM_BLOCK);o=e.indexOf("\n",o);let a=o;for(let c=0;c<t;c++){o=e.indexOf(l.V3K_BEGIN_DATA_LINE,o)+l.V3K_IDX_SHIFT,a=e.indexOf(" ",o),o=a+1,a=e.indexOf(" ",o),n[c]=e.substring(o,a);const t=new Array(2);for(let n=0;n<2;++n)o=a+1,a=e.indexOf(" ",o),t[n]=parseFloat(e.substring(o,a));r[c]=t[0],i[c]=t[1],o=a,a=e.indexOf("\n",o)+1,s[c]=e.slice(o,a),o=a}return{atomTypes:n,x:r,y:i,kwargs:s}}(u,h.atomCount),g=function(e,t){const n=new Uint32Array(t),r=new Array(t),i=new Map,s=new Map;let o=e.indexOf(l.V3K_BEGIN_BOND_BLOCK);o=e.indexOf("\n",o);let a=o;for(let c=0;c<t;++c){const t=new Array(3);o=e.indexOf(l.V3K_BEGIN_DATA_LINE,a)+l.V3K_IDX_SHIFT,a=e.indexOf(" ",o);for(let n=0;n<3;++n)o=a+1,a=Math.min(e.indexOf("\n",o),e.indexOf(" ",o)),t[n]=parseInt(e.slice(o,a));n[c]=t[0],r[c]=t.slice(1);const u=e.indexOf("\n",o);let d=e.slice(a,u),h=d.indexOf(l.V3K_BOND_CONFIG);if(-1!==h){h=d.indexOf("=",h)+1;let e=d.indexOf(" ",h);-1===e&&(e=d.length);const t=parseInt(d.slice(h,e));i.set(c,t);const n=l.V3K_BOND_CONFIG+t.toString();d=d.replace(n,"")}d||s.set(c,d)}return{bondTypes:n,atomPairs:r,bondConfiguration:i,kwargs:s}}(u,h.bondCount),w=function(e,t,n,r){const i={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[r,i]of n)e.atomTypes[r-1]=t[i-1]}(e,n,r),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const r of[1,2])if(e.get(t.rNodes[n])===r){const e=t.rNodes[r-1];t.rNodes[r-1]=t.rNodes[n],t.rNodes[n]=e}}(r,i),m(t,i),i}(p,g,a,c),C=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const r=e.indexOf(")",n);t=t.concat(e.substring(n,r).split(" ").slice(1).map((e=>parseInt(e)))),n=r,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),T={atoms:p,bonds:g,meta:w,stereoAtoms:C};return"PEPTIDE"===r?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,r=e.atoms.x,i=e.atoms.y;E(e,-r[t],-i[t]);const s=b(r[n],i[n]);v(e.atoms,-s),r[e.meta.rNodes[1]-1]<0&&function(e){A(e,!1)}(e);const o=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const r=n[e],i=n[(e+1)%2];t.has(r)?t.get(r)?.push(i):t.set(r,new Array(1).fill(i))}return t}(e);let n=0;const r=e.atoms.atomTypes.length;let i=0;for(;0===n;){const s=t.get(e.meta.terminalNodes[1])[i];if(e.atoms.atomTypes[s-1]===l.OXYGEN&&s!==e.meta.rNodes[1]&&(n=s),i++,i>r)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${r}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){A(e,!0)}(e),v(e.atoms,-function(e,t){return b(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,o),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const r=t-1,i=n-1,s=e.atoms.x,o=e.atoms.y,a=s[r],c=o[r];s[r]=s[i],o[r]=o[i],s[i]=a,o[i]=c}(e,t,e.meta.rNodes[1])}(e,o)}(T):e===l.RIBOSE||e===l.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,r=e.atoms.y;let i=e.meta.terminalNodes[0]-1;const s=e.meta.rNodes[1]-1;E(e,-n[i],-r[i]);const o=b(n[s],r[s]);v(e.atoms,3*Math.PI/2-o),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,r=e.meta.rNodes[2]-1,i=e.meta.terminalNodes[2]-1,s=t[r]-t[i],o=n[r]-n[i];return Math.atan(o/s)+Math.PI/2}(e),i=e.meta.terminalNodes[0]-1,E(e,-n[i],-r[i])}(T,i):e===l.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,r=e.atoms.x,i=e.atoms.y;E(e,-r[t],-i[t]);const s=b(r[n],i[n]);v(e.atoms,Math.PI/2-s)}(T):function(e,t){const n=e.atoms.x,r=e.atoms.y,i=e.meta.terminalNodes[0]-1,s=e.meta.rNodes[0]-1;E(e,-n[i],-r[i]);const o=b(n[s],r[s]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");v(e.atoms,Math.PI-o+a);const c=function(e,t){return d(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:r[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:r[e.meta.terminalNodes[0]-1]});if(1!=c)for(let e=0;e<n.length;++e)n[e]=d(n[e]/c),r[e]=d(r[e]/c)}(T,i),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===l.RIBOSE||n===l.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],m(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===l.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],E(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(r,T,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===l.HYDROGEN&&(y(e,t+1),--t),++t}(T),T}var s;return null}(t,n,r,i,s);if(!o)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,o)}}function m(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const r=t.terminalNodes,i=e.atomPairs;let s=0,o=0;for(;s<i.length&&o<r.length;){for(let e=0;e<r.length;++e)for(let t=0;t<2;++t)i[s][t]===n[e]&&(r[e]=i[s][(t+1)%2],n.length,++o);++s}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[d(e.atoms.x[t]-e.atoms.x[n]),d(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,r=e.atoms,i=e.bonds,s=e.meta;r.atomTypes.splice(n,1),r.x=w(Float32Array,r.x,n,1),r.y=w(Float32Array,r.y,n,1),r.kwargs.splice(n,1);for(let e=0;e<s.terminalNodes.length;++e)s.terminalNodes[e]>t?--s.terminalNodes[e]:s.terminalNodes[e]===t&&(s.terminalNodes[e]=-1);for(let e=0;e<s.rNodes.length;++e)s.rNodes[e]>t?--s.rNodes[e]:s.rNodes[e]===t&&(s.rNodes[e]=-1);let o=0;for(;o<i.atomPairs.length;){const e=i.atomPairs[o][0],n=i.atomPairs[o][1];e===t||n===t?(i.atomPairs.splice(o,1),i.bondTypes=w(Uint32Array,i.bondTypes,o,1),i.bondConfiguration.has(o)&&i.bondConfiguration.delete(o),i.kwargs.has(o)&&i.kwargs.delete(o),--o):(i.atomPairs[o][0]=e>t?e-1:e,i.atomPairs[o][1]=n>t?n-1:n),++o}let a=Array.from(i.bondConfiguration.keys());a.forEach((e=>{if(i.bondConfiguration.has(e)&&e>n){const t=i.bondConfiguration.get(e);i.bondConfiguration.delete(e),i.bondConfiguration.set(e-1,t)}})),a=Array.from(i.kwargs.keys()),a.forEach((e=>{if(i.kwargs.has(e)&&e>n){const t=i.kwargs.get(e);i.kwargs.delete(e),i.kwargs.set(e-1,t)}}))}}function w(e,t,n,r){const i=new e(t.length-r);let s=0,o=0;for(;s<t.length;)s===n&&(s+=r),i[o]=t[s],++o,++s;return i}function b(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const r=t/e,i=Math.atan(r);n=e<0?Math.PI/2+i:-Math.PI/2+i}return n}function v(e,t){if(0!==t){const n=e.x,r=e.y,i=Math.cos(t),s=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=d(t*i-r[e]*s),r[e]=d(t*s+r[e]*i)}}}function A(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const r=1===t?3:1;n.set(e,r)}}function E(e,t,n){const r=e.atoms.x,i=e.atoms.y;for(let e=0;e<r.length;++e)r[e]=d(r[e]+t),void 0!==n&&(i[e]=d(i[e]+n))}},1093:(e,t,n)=>{"use strict";n.d(t,{A:()=>i,Q:()=>s});var r=n(7362);class i extends r.e{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new i({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class s{}s.SemType="Nucleotides",s.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",s.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>r});class r{static makePalette(e,t=!1,n=r){const i={};return e.forEach((e=>{const n=e[0],r=e[1];n.forEach(((e,n)=>{i[e]=this.colourPalette[r][t?0:n]}))})),new n(i)}constructor(e){this._palette=e}get(e,t){return this._palette[e]}}r.undefinedColor="rgb(100,100,100)",r.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4152:(e,t,n)=>{"use strict";n.d(t,{$u:()=>c,oT:()=>d});var r=n(6082),i=n(7362),s=n(6718);function o(e){if(null==e)return"rgb(100,100,100)";const t=r.Color.fromHtml(e),n=r.Color.g(t),i=r.Color.r(t),s=r.Color.b(t),o=Math.sqrt(Math.pow(0-i,2)+Math.pow(0-n,2)+Math.pow(0-s,2));return o>210?`rgb(${i/o*210},${n/o*210},${s/o*210})`:r.Color.toRgb(t)}class a{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class c{}class l extends c{get(e,t){return"#666666"}}class u extends c{static buildPalette(){return(0,s.pj)().then((e=>{e.awaitLoaded().then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{u.customMonomerColors={},u.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const r of n){const n=t.getMonomer(e,r);n?.meta?.colors?.default?.background&&(this.customMonomerColors[r]||(this.customMonomerColors[r]={}),this.customMonomerColors[r][e]=o(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(i.e.colourPalette))}get(e,t){const n=u.customMonomerColors[e],r=t??"PEPTIDE";if(n&&n[r])return n[r];const i=a.hashCode(e)%u.palette.length;return o(u.palette[i])}}u.palette=u.buildPalette(),u.customMonomerColors={},u.polymerTypes=[];class d extends i.e{static get Gray(){return void 0===this.gray&&(this.gray=new l),this.gray}static get Color(){return void 0===this.color&&(this.color=new u),this.color}}},6642:(e,t,n)=>{"use strict";n.d(t,{h:()=>o,s:()=>a});var r=n(4328),i=n(1858),s=n(8070);function o(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const r=e.cell.column;if(t=t??r.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,r,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new i.Subject,this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.tableCol&&this.subs.push(r.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(r.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,s.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},6882:(e,t,n)=>{"use strict";n.d(t,{B:()=>u,J:()=>d});var r=n(6082),i=n(1991),s=n.n(i),o=n(826),a=n(6642),c=n(6718),l=n(9192);function u(e,t){let n,r=100,i=0,s=e.length-1;for(;i<=s;){if(n=Math.floor((s+i)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?s=n-1:i=n+1,--r<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}class d extends a.s{constructor(e,t,n,i,s){super(e,t,n),this.monomerLengthLimit=i,this.propsProvider=s,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=r.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,c.pj)().then((e=>{if(this.destroyed)return;const t=e.getMonomerLib();this.subs.push(t.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=r.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset()}getCellMonomerLengths(e,t){if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,l.AP)(e);this.logger.error(t,void 0,n)}const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),r=new Array(n.length+1);r[0]=5;for(let e=1;e<r.length;e++)r[e]=r[e-1]+n[e-1];return[n,r]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),r=o.GO.forColumn(this.tableCol).getSplitted(e).originals,i=Math.min(n,r.length);let s=this._monomerLengthList[e];if(null===s||s.length<i){s=this._monomerLengthList[e]=new Array(r.length);let t=0;for(let e=0;e<i;++e){const n=r[e],i=this.props.monomerToShort(n,this.monomerLengthLimit),o=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+i.length*this.props.monomerCharWidth;if(s[e]=o,t+=o,t>this.colWidth)break}}return s}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:r}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),i=this.props.separatorWidth+1*this.props.monomerCharWidth,s=Math.ceil(this.colWidth/i);for(let e=n;e<r;e++){if(this._processedRows.get(e)&&s<=this._processedMaxVisibleSeqLength)continue;const n=o.GO.forColumn(this.tableCol).getSplitted(e,s).originals,r=Math.min(s,n.length);r>t.length&&t.push(...new Array(r-t.length).fill(i));let a=0;for(let e=0;e<r;++e){const r=n[e],i=this.props.monomerToShort(r,this.monomerLengthLimit),s=this.props.separatorWidth+i.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,s),a+=s,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,s)}return t}getPosition(e,t,n){const[r,i]=this.getCellMonomerLengths(e,n),a=o.GO.forColumn(this.tableCol);return 0===s()(a.getSplitted(e).originals).toArray().length?null:u(i,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.dirty=!0}setSeparatorWidth(e){this.props.separatorWidth=e,this.dirty=!0}isMsa(){return this.props.seqHandler.isMsa()}}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>s,f6:()=>r,q7:()=>i});const r=["symbol","molfile","rgroups","name"],i="p",s=new RegExp(`[rd]\\((\\w)\\)${i}?`,"g")},9192:(e,t,n)=>{"use strict";function r(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function i(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):void 0}function s(e){return[r(e),i(e)]}n.d(t,{AP:()=>s})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>o});var r=n(6082),i=n(826),s=n(439);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const r=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(r),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=r.Column.fromStrings("description",this.descriptionsArray),t=r.Column.fromStrings("sequence",this.sequencesArray);return t.semType=r.SEMTYPE.MACROMOLECULE,t.meta.units=s.Hi.FASTA,i.GO.forColumn(t),[r.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{dW:()=>o,fD:()=>s});var r=n(6082),i=(n(1991),n(2003));function s(){const e=[];return e.push(r.Column.fromList("string","MSA",new Array(10**6).fill("meI/hHis/Aca/N/T/dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"))),e.push(r.Column.fromList(r.COLUMN_TYPE.FLOAT,"Activity",new Array(10**6).fill(5.30751))),e}function o(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=r.Column.fromList(r.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=r.SEMTYPE.MACROMOLECULE,n.meta.units=i.Hi.SEPARATOR,n.setTag(i.gp.separator,"/"),n.setTag(i.gp.alphabet,i.YI.UN),n.setTag(i.gp.alphabetIsMultichar,"true");const s=[];return s.push(n),s.push(r.Column.fromList(r.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),s}n(826),n(9322)},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>c,Hi:()=>r,Vl:()=>l,YI:()=>i,gp:()=>s,q7:()=>u,z1:()=>a});var r,i,s,o=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(r||(r={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(i||(i={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(s||(s={}));const a=", ",c=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,l=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new o.aD(i.PT,l.fasta.peptide,.5),new o.aD(i.DNA,l.fasta.dna,.55),new o.aD(i.RNA,l.fasta.rna,.55)]},2003:(e,t,n)=>{"use strict";n.d(t,{Hi:()=>r.Hi,J9:()=>i.J9,Qf:()=>i.Qf,SM:()=>i.SM,YI:()=>r.YI,dh:()=>i.dh,gp:()=>r.gp,mn:()=>i.mn,nq:()=>i.nq,ny:()=>i.ny,q7:()=>r.q7,qp:()=>i.qp,z1:()=>r.z1,zS:()=>i.zS});var r=n(439),i=n(9322)},2738:(e,t,n)=>{"use strict";n.d(t,{XN:()=>s,_S:()=>r,aD:()=>i});const r="";class i{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class s extends i{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},9322:(e,t,n)=>{"use strict";n.d(t,{Mu:()=>m,pc:()=>x,Qf:()=>_,nq:()=>P,ny:()=>$,Iv:()=>C,dh:()=>b,vZ:()=>g,zS:()=>S,SM:()=>M,mn:()=>N,J9:()=>y,tm:()=>w,qp:()=>E});var r=n(6082),i=n(1991),s=n.n(i),o=n(2738),a=n(439),c=n(826);class l extends Float32Array{}var u=n(3629),d=n(8924),h=n(1093),p=n(4152);class m{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===c.b9[a.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?o._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}function g(e,t,n){const r=e.categories;return function(e,t){const n={};let r=!0,i=null;for(const s of e)if(null==i?i=s.length:s.length!==i&&(r=!1),s.length>=t)for(const e of s.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:r}}(s().enumerate(e.getRawData()).map((([e,t])=>n(r[e]))),t)}const y=e=>{const t=s()(e.toString().matchAll(a.B5)).map((e=>e[2]??e[1])).toArray();return new m(t,c.b9[a.Hi.FASTA])},w=e=>e?new f(e):new m([],c.b9[a.Hi.FASTA]);function b(e,t=void 0){return n=>{if(n){let r;const i=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){i.lastIndex=0,r=new Array(Math.ceil(t));let e=null,s=0;for(;null!==(e=i.exec(n))&&s<t;)r[s++]=e[0].replace('"-"',"").replace("'-'","");r.splice(s)}else r=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new m(r,c.b9[a.Hi.SEPARATOR])}return new m([],c.b9[a.Hi.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,A=/\[([^\[\]]+)]/g,E=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,r=n?n.split("."):[];return new m(r.map((e=>{A.lastIndex=0;const t=A.exec(e);return t&&t.length>=2?t[1]:e})),c.b9[a.Hi.HELM])};function C(e,t,n=void 0){if(e.toLowerCase().startsWith(a.Hi.FASTA))return y;if(e.toLowerCase().startsWith(a.Hi.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.Hi.HELM))return E;throw new Error(`Unexpected units ${e} .`)}const T=/([^\W_]+)/g;function S(e,t){if(e.length<=t)return e;const n=e.match(T),r=e.length>t||(n?.length??0)>1,i=n?.[0]??" ";return r?i.substring(0,t-1)+"…":i}function _(e){switch(e){case a.YI.DNA:return a.Vl.fasta.dna;case a.YI.RNA:return a.Vl.fasta.rna;case a.YI.PT:return a.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function P(e,t,n="-"){const r=new Set([...new Set(Object.keys(e)),...t]);r.delete(n);const i=[],s=[];for(const n of r)i.push(n in e?e[n]:0),s.push(t.has(n)?1:0);const o=new l(i),a=new l(s);return(0,u.KE)(o,a)/((0,u.wQ)(o)*(0,u.wQ)(a))}function x(e,t,n="-"){const r=t.map((t=>{const r=P(e,t.alphabet,n);return new o.XN(t,e,r)}));let i;const s=Math.max(...r.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return i=s>0?r.find((e=>e.similarity===s)).name:a.YI.UN,i}function M(e,t=5){let n;return n=e.semType==r.SEMTYPE.MACROMOLECULE?c.GO.forColumn(e).alphabet:x(g(e,t,y).freq,a.q7),$(n)}function $(e){switch(e){case a.YI.PT:return d.X.GrokGroups;case a.YI.DNA:case a.YI.RNA:return h.A.Chromatogram;default:return p.oT.Color}}function N(e){const t=e.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},826:(e,t,n)=>{"use strict";n.d(t,{GO:()=>m,b9:()=>p});var r=n(6082),i=n(1991),s=n.n(i),o=n(2003),a=n(2738),c=n(9322),l=n(6863),u=n(6718),d=n(3151);const h=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},p={[o.Hi.FASTA]:"-",[o.Hi.SEPARATOR]:"",[o.Hi.HELM]:"*"};class m{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==r.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${r.TYPE.STRING}'.`);this._column=e;const t=this._column.meta.units;if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?p[o.Hi.FASTA]:this.isHelm()?p[o.Hi.HELM]:p[o.Hi.SEPARATOR],!this.column.tags.has(o.gp.aligned)||!this.column.tags.has(o.gp.alphabet)||!this.column.tags.has(o.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===o.YI.UN)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(o.gp.separator);m.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.meta.units}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(o.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(o.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${o.gp.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[h.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE||e.column.meta.units!==o.Hi.FASTA)throw new Error(`The column of notation '${o.Hi.FASTA}' must be '${r.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=o.Hi.FASTA,m.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE||e.column.meta.units!==o.Hi.SEPARATOR)throw new Error(`The column of notation '${o.Hi.SEPARATOR}' must be '${r.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${o.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=o.Hi.SEPARATOR,e.column.setTag(o.gp.separator,t),m.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.Hi.HELM}' must be '${r.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=o.Hi.HELM,m.setTags(e)}static setTags(e){const t=e.column.meta.units;if([o.Hi.FASTA,o.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(o.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(o.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(o.gp.aligned,t));let n=e.column.getTag(o.gp.alphabet);if(null===n&&(n=(0,c.pc)(e.stats.freq,o.q7),e.column.setTag(o.gp.alphabet,n)),n===o.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(o.gp.alphabetSize,t.toString()),e.column.setTag(o.gp.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(o.gp.separator)??void 0;if(this.notation===o.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(o.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(o.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(o.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==o.Hi.HELM||this.alphabet==o.YI.UN){const e=this.column.getTag(o.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case o.YI.PT:return 20;case o.YI.DNA:case o.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.Hi.HELM||this.alphabet===o.YI.UN&&"true"===this.column.getTag(o.gp.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}async getHelm(e,t){const n=this.column.get(e);return this.notationProvider?(await this.notationProvider.getHelm(this.column,t)).get(e):this.convertToHelm(n)}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const r=this.column.length;for(let i=0;i<r;++i){const r=this.getSplitted(i);null==n?n=r.length:r.length!==n&&(t=!1);for(const t of r.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...s().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(o.gp.positionNames);this._posList=e?e.split(o.z1).map((e=>e.trim())):s().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.Hi.FASTA}isSeparator(){return this.notation===o.Hi.SEPARATOR}isHelm(){return this.notation===o.Hi.HELM}isRna(){return this.alphabet===o.YI.RNA}isDna(){return this.alphabet===o.YI.DNA}isPeptide(){return this.alphabet===o.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(o.Hi.FASTA))return o.Hi.FASTA;if(this.units.toLowerCase().startsWith(o.Hi.SEPARATOR))return o.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(o.Hi.HELM))return o.Hi.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,i){const s=this.column,a=e.toLowerCase()+"("+s.name+")",c=n??s.dataFrame.columns.getUnusedName(a),l=r.Column.fromList("string",c,i??new Array(this.column.length).fill(""));if(l.semType=r.SEMTYPE.MACROMOLECULE,l.meta.units=e,e===o.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${o.Hi.SEPARATOR}' requires separator value.`);l.setTag(o.gp.separator,t)}l.setTag(r.TAGS.CELL_RENDERER,e===o.Hi.HELM?"helm":"sequence");const u=s.getTag(o.gp.aligned);u&&l.setTag(o.gp.aligned,u);let d=s.getTag(o.gp.alphabet);d||this.notation!==o.Hi.HELM||e===o.Hi.HELM||(d=o.YI.UN),null!=d&&l.setTag(o.gp.alphabet,d);let h=s.getTag(o.gp.alphabetSize);null!=d&&h&&l.setTag(o.gp.alphabetSize,h);const p=s.getTag(o.gp.alphabetIsMultichar);return null!=d&&void 0!==p&&l.setTag(o.gp.alphabetIsMultichar,p),e==o.Hi.HELM&&(h=this.getAlphabetSize().toString(),l.setTag(o.gp.alphabetSize,h)),l}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=m.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[o.Hi.FASTA,o.Hi.SEPARATOR,o.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!m.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const i=r.Column.fromList("string",t,new Array(e).fill(""));return i.semType=r.SEMTYPE.MACROMOLECULE,i.meta.units=n,i}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(o.Hi.FASTA))return null===this.column.getTag(o.gp.alphabet)||this.getAlphabetIsMultichar()?o.J9:c.tm;if(this.units.toLowerCase().startsWith(o.Hi.SEPARATOR))return(0,o.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(o.Hi.HELM))return o.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return l.Z.HAMMING;switch(this.alphabet){case o.YI.DNA:case o.YI.RNA:case o.YI.PT:}return l.Z.LEVENSHTEIN}getDistanceFunction(){return l.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(o.gp.isHelmCompatible))return"true"===this.column.getTag(o.gp.isHelmCompatible);const e=(await(0,u.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,o.dh)(this.separator),new Set),r=this.column.length,i=this.column.getRawData();for(let e=0;e<r;++e){const r=i[e];if(!(r in n)){n.add(r);const i=this.getSplitted(e);for(const e of i.canonicals)if(!t.has(e))return this.column.setTag(o.gp.isHelmCompatible,"false"),!1}}return this.column.setTag(o.gp.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===o.Hi.FASTA}toSeparator(e){return e===o.Hi.SEPARATOR}toHelm(e){return e===o.Hi.HELM}convertHelmToFastaSeparator(e,t,n,r){r||(r=this.toFasta(t)?p[o.Hi.FASTA]:p[o.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const i=e.startsWith("RNA"),s=this.splitter(e),a=[];for(let e=0;e<s.length;++e){let n=s.getOriginal(e);if(i&&(n=n.replace(d.EK,"")),n===p[o.Hi.HELM])a.push(r);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),r=this.getNewColumn(e,t);return r.init((e=>{const t=this.getSplitted(e);return n(t)})),r}getRegion(e,t,n){const r=this.getNewColumn(this.notation,this.separator);r.name=n;const i=e??0,s=t??this.maxLength-1,a=this.getJoiner(),l=s-i+1,u=p[this.notation];r.init((e=>{const t=this.getSplitted(e),n=new Array(l);for(let e=0;e<l;++e){const r=i+e;n[e]=r<t.length?t.getOriginal(r):u}return a(new c.Mu(n,u))}));const d=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(l);for(let e=0;e<l;++e){const r=i+e;n[e]=r<t.length?t[r]:"?"}return n.join(o.z1)},h=this.column.getTag(o.gp.positionNames);h&&r.setTag(o.gp.positionNames,d(h));const m=this.column.getTag(o.gp.positionLabels);return m&&r.setTag(o.gp.positionLabels,d(m)),r}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let r;const i=this;switch(t){case o.Hi.FASTA:r=function(e){return i.joinToFasta(e,i.isHelm())};break;case o.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);r=function(e){return f(e,n,i.isHelm())};break;case o.Hi.HELM:{const e=i.alphabet===o.YI.DNA||i.alphabet===o.YI.RNA,t=i.getHelmWrappers();r=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return r}getConverter(e,t=void 0){if(e===o.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${o.Hi.SEPARATOR}'.`);const n=this;if(e===o.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===o.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===o.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[h.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[h.seqHandler]=new m(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let r=0;r<e.length;++r){const i=e.getOriginal(r);let s=e.getOriginal(r);t&&(s=s.replace(d.EK,"$1")),i===a._S?s=p[o.Hi.FASTA]:i===d.q7?s="":s.length>1&&(s="["+s+"]"),n[r]=s}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==o.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),r=e.startsWith("DNA"),i=e.startsWith("RNA");for(let e=0;e<t.length;++e){let s=t.getOriginal(e);(r||i)&&(s=s.replace(d.EK,"$1"),s=s===d.q7?null:s),n[e]=s||null}return new c.Mu(n.filter((e=>!!e)),p[o.Hi.HELM])}}function f(e,t,n){const r=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let s=e.getOriginal(t);n&&(s=s.replace(d.EK,"$1")),i===a._S?s=p[o.Hi.SEPARATOR]:i===d.q7&&(s=""),r[t]=s}return r.join(t)}function g(e,t,n){const[r,i,s,c]=t,l=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let c=e.getOriginal(t);r===a._S?c=p[o.Hi.HELM]:(n&&(c=c.replace(d.EK,"$1")),c=1===c.length?`${i}${c}${s}`:`${i}[${c}]${s}`),l[t]=c}return`${r}${l.join(".")}${c}`}},8312:(e,t,n)=>{"use strict";n.d(t,{Q:()=>i});var r=n(6082);async function i(){const e=r.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>s});var r=n(6082),i=n(826);function s(e){const t=e=>{const t=o.columns.addNewString((e+1).toString());return n.push(t),t},n=[],s=e.length,o=r.DataFrame.create(s),a=i.GO.forColumn(e);for(let e=0;e<s;++e){const r=a.getSplitted(e);for(let i=0;i<r.length;++i){const s=r.getOriginal(i);((n[i]??null)||t(i)).set(e,s,!1)}}return o}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>s});var r,i=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(r||(r={}));class s{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[r,s]=(0,i.AP)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${r}`,void 0,s),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},4326:(e,t,n)=>{"use strict";n.d(t,{Fo:()=>u,Lp:()=>s,P4:()=>o,fH:()=>i,gp:()=>r,lT:()=>c,mH:()=>a});var r,i,s,o,a,c,l=n(6082);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(r||(r={})),function(e){e.Entropy="Entropy",e.full="100%"}(i||(i={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(s||(s={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(o||(o={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(c||(c={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=l.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=i.Entropy,this.positionWidth=16,this.verticalAlignment=s.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=c.Filtered}}},5540:(e,t,n)=>{"use strict";e=n.hmd(e);var r,i=(r="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,i=void 0!==e?e:{};i.ready=new Promise((function(e,r){t=e,n=r}));var s,o=Object.assign({},i),a="object"==typeof window,c="function"==typeof importScripts,l=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||c)&&(c?l=self.location.href:"undefined"!=typeof document&&document.currentScript&&(l=document.currentScript.src),r&&(l=r),l=0!==l.indexOf("blob:")?l.substr(0,l.replace(/[?#].*/,"").lastIndexOf("/")+1):"",c&&(s=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),i.print||console.log.bind(console);var u,d,h=i.printErr||console.warn.bind(console);Object.assign(i,o),o=null,i.arguments&&i.arguments,i.thisProgram&&i.thisProgram,i.quit&&i.quit,i.wasmBinary&&(u=i.wasmBinary),i.noExitRuntime,"object"!=typeof WebAssembly&&T("no native wasm support detected");var p,m,f,g=!1;function y(){var e=d.buffer;i.HEAP8=p=new Int8Array(e),i.HEAP16=new Int16Array(e),i.HEAP32=new Int32Array(e),i.HEAPU8=m=new Uint8Array(e),i.HEAPU16=new Uint16Array(e),i.HEAPU32=f=new Uint32Array(e),i.HEAPF32=new Float32Array(e),i.HEAPF64=new Float64Array(e)}var w=[],b=[],v=[],A=0,E=null,C=null;function T(e){i.onAbort&&i.onAbort(e),h(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var S,_;function P(e){return e.startsWith("data:application/octet-stream;base64,")}function x(e){try{if(e==S&&u)return new Uint8Array(u);if(s)return s(e);throw"both async and sync fetching of the wasm failed"}catch(e){T(e)}}function M(e,t,n){return function(e){return u||!a&&!c||"function"!=typeof fetch?Promise.resolve().then((function(){return x(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return x(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){h("failed to asynchronously prepare wasm: "+e),T(e)}))}function $(e){for(;e.length>0;)e.shift()(i)}function N(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,p[this.ptr+12|0]=e},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(e){e=e?1:0,p[this.ptr+13|0]=e},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(U(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function L(e){var t=d.buffer;try{return d.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function I(e){return i["_"+e]}P(S="wasmDbscan.wasm")||(_=S,S=i.locateFile?i.locateFile(_,l):l+_);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(e,t,n,r,i){var s={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var r=e.charCodeAt(n);r<=127?t++:r<=2047?t+=2:r>=55296&&r<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=F(t);return function(e,t,n){!function(e,t,n,r){if(!(r>0))return 0;for(var i=n+r-1,s=0;s<e.length;++s){var o=e.charCodeAt(s);if(o>=55296&&o<=57343&&(o=65536+((1023&o)<<10)|1023&e.charCodeAt(++s)),o<=127){if(n>=i)break;t[n++]=o}else if(o<=2047){if(n+1>=i)break;t[n++]=192|o>>6,t[n++]=128|63&o}else if(o<=65535){if(n+2>=i)break;t[n++]=224|o>>12,t[n++]=128|o>>6&63,t[n++]=128|63&o}else{if(n+3>=i)break;t[n++]=240|o>>18,t[n++]=128|o>>12&63,t[n++]=128|o>>6&63,t[n++]=128|63&o}}t[n]=0}(e,m,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,r=F(e.length);return t=e,n=r,p.set(t,n),r}},o=I(e),a=[],c=0;if(r)for(var l=0;l<r.length;l++){var u=s[n[l]];u?(0===c&&(c=H()),a[l]=u(r[l])):a[l]=r[l]}var d=o.apply(null,a);return function(e){return 0!==c&&D(c),function(e){return"string"===t?(n=e)?function(e,t,n){for(var r=t+n,i=t;e[i]&&!(i>=r);)++i;if(i-t>16&&e.buffer&&R)return R.decode(e.subarray(t,i));for(var s="";t<i;){var o=e[t++];if(128&o){var a=63&e[t++];if(192!=(224&o)){var c=63&e[t++];if((o=224==(240&o)?(15&o)<<12|a<<6|c:(7&o)<<18|a<<12|c<<6|63&e[t++])<65536)s+=String.fromCharCode(o);else{var l=o-65536;s+=String.fromCharCode(55296|l>>10,56320|1023&l)}}else s+=String.fromCharCode((31&o)<<6|a)}else s+=String.fromCharCode(o)}return s}(m,n,r):"":"boolean"===t?Boolean(e):e;var n,r}(e)}(d)}var k,G={__cxa_throw:function(e,t,n){throw new N(e).init(t,n),e},abort:function(){T("")},emscripten_memcpy_big:function(e,t,n){m.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=m.length,r=2147483648;if((e>>>=0)>r)return!1;for(var i=1;i<=4;i*=2){var s=n*(1+.2/i);if(s=Math.min(s,e+100663296),L(Math.min(r,(t=Math.max(e,s))+(65536-t%65536)%65536)))return!0}return!1}},H=(function(){var e,t,r,s,o={env:G,wasi_snapshot_preview1:G};function a(e,t){var n,r=e.exports;return i.asm=r,d=i.asm.memory,y(),i.asm.__indirect_function_table,n=i.asm.__wasm_call_ctors,b.unshift(n),function(){if(A--,i.monitorRunDependencies&&i.monitorRunDependencies(A),0==A&&(null!==E&&(clearInterval(E),E=null),C)){var e=C;C=null,e()}}(),r}if(A++,i.monitorRunDependencies&&i.monitorRunDependencies(A),i.instantiateWasm)try{return i.instantiateWasm(o,a)}catch(e){h("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=S,r=o,s=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||P(t)||"function"!=typeof fetch?M(t,r,s):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,r).then(s,(function(e){return h("wasm streaming compile failed: "+e),h("falling back to ArrayBuffer instantiation"),M(t,r,s)}))}))).catch(n)}(),i._dbscan=function(){return(i._dbscan=i.asm.dbscan).apply(null,arguments)},i._malloc=function(){return(i._malloc=i.asm.malloc).apply(null,arguments)},i._free=function(){return(i._free=i.asm.free).apply(null,arguments)},function(){return(H=i.asm.stackSave).apply(null,arguments)}),D=function(){return(D=i.asm.stackRestore).apply(null,arguments)},F=function(){return(F=i.asm.stackAlloc).apply(null,arguments)},U=function(){return(U=i.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function e(){k||(k=!0,i.calledRun=!0,g||($(b),t(i),i.onRuntimeInitialized&&i.onRuntimeInitialized(),function(){if(i.postRun)for("function"==typeof i.postRun&&(i.postRun=[i.postRun]);i.postRun.length;)e=i.postRun.shift(),v.unshift(e);var e;$(v)}()))}A>0||(function(){if(i.preRun)for("function"==typeof i.preRun&&(i.preRun=[i.preRun]);i.preRun.length;)e=i.preRun.shift(),w.unshift(e);var e;$(w)}(),A>0||(i.setStatus?(i.setStatus("Running..."),setTimeout((function(){setTimeout((function(){i.setStatus("")}),1),e()}),1)):e()))}if(i.ccall=O,i.cwrap=function(e,t,n,r){var i=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&i&&!r?I(e):function(){return O(e,t,n,arguments)}},C=function e(){k||V(),k||(C=e)},i.preInit)for("function"==typeof i.preInit&&(i.preInit=[i.preInit]);i.preInit.length>0;)i.preInit.pop()();return V(),e.ready});"object"==typeof exports?e.exports=i:"function"==typeof define&&n.amdO?define([],(function(){return i})):"object"==typeof exports&&(exports.exportCppDbscanLib=i)},6295:(e,t,n)=>{"use strict";n.d(t,{$1:()=>a,Hr:()=>C,Ii:()=>m,T6:()=>E,TK:()=>v,a4:()=>h,be:()=>p,gt:()=>y,iS:()=>o,ij:()=>w,lO:()=>d,lP:()=>g,rR:()=>f,tO:()=>c,v_:()=>l,yK:()=>b,zn:()=>u});var r=n(8774),i=n(8498),s=n(6863);i.aT.Tanimoto,i.aT.Dice,i.aT.Asymmetric,i.aT.BraunBlanquet,i.aT.Cosine,i.aT.Kulczynski,i.aT.McConnaughey,i.aT.RogotGoldberg,i.aT.Russel,i.aT.Sokal,i.aT.Hamming,i.aT.Euclidean,i.aT.Tanimoto,i.aT.Dice,i.aT.Asymmetric,i.aT.BraunBlanquet,i.aT.Cosine,i.aT.Kulczynski,i.aT.McConnaughey,i.aT.RogotGoldberg,i.aT.Russel,i.aT.Sokal,i.aT.Hamming,i.aT.Euclidean;const o=[i.aT.Tanimoto,i.aT.Dice,i.aT.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const r=e.andWithCountBits(t,!0);return r/(n-r)}function c(e,t){return 1-a(e,t)}function l(e,t){return A(a(new r.A(e,32*e.length),new r.A(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function d(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function h(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function p(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function m(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),r=e.andWithCountBits(t,!0);return r/(2*n-3*r)}(e,t)}function f(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),r=e.trueCount()*t.trueCount();return 0==r?0:e.andWithCountBits(t,!0)*n/(2*r)}(e,t))}function g(e,t){return A(function(e,t){const n=e.trueCount()+t.trueCount(),r=e.trueCount()*t.trueCount();return 0==r?0:(e.andWithCountBits(t,!0)*n-r)/r}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function w(e,t){return A(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function b(e,t){return A(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function v(e,t){return A(function(e,t){const n=e.andWithCountBits(t,!0),r=e.countBits(!0)+t.countBits(!0),i=e.length,s=i-r+n;return n==i||s==i?1:n/r+s/(2*i-r)}(e,t))}function A(e){return 0===e?3402823e32:1/e-1}function E(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function C(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const r=e.length,i=n.length;let s=0,o=0,a=0;for(;o<r&&a<i;)e[o]===n[a]?(t?.has(e[o])||++s,++o,++a):e[o]<n[a]?++o:++a;return s}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}i.aT.Tanimoto,i.aT.Asymmetric,i.aT.Cosine,i.aT.Sokal,s.Z.HAMMING,s.Z.LEVENSHTEIN,s.Z.MONOMER_CHEMICAL_DISTANCE,s.Z.NEEDLEMANN_WUNSCH},684:(e,t,n)=>{"use strict";n.d(t,{C0:()=>s,GP:()=>r,Gi:()=>a,YP:()=>l,_X:()=>o,n3:()=>i,vb:()=>c});const r="dim-red-preprocessing-function",i="supportedSemTypes",s="supportedTypes",o="supportedUnits",a="supportedDistanceFunctions",c="bypassLargeDataWarning",l="show-scatterplot-progress"},6863:(e,t,n)=>{"use strict";function r(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,r=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,i=new Float32Array((n.length+r)*(n.length+r));return Object.entries(t).forEach((([e,r])=>{const s=n[r];Object.entries(t).forEach((([t,r])=>{i[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=s[r]}))})),(e,t)=>1-i[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,r)=>{let i=0;const s=e.length,o=r.length,a=Math.ceil(Math.max(s,o)*(1-n));s!==o&&(i=Math.abs(s-o));let c=0;for(let n=0;n<Math.min(s,o);n++)if(e[n]!==r[n]&&(c+=t(e[n],r[n]),c>a))return 1;return c+=i,c/=Math.max(s,o),c}}n.d(t,{Z:()=>o,V:()=>a});var i=n(2787);const s={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var o;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(o||(o={}));const a={[o.HAMMING]:r,[o.LEVENSHTEIN]:function(){return(e,t)=>(0,i.I)(e,t)/Math.max(e.length,t.length)},[o.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:r,scoringMatrix:i,alphabetIndexes:o}={...s,...e};Object.entries(o).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,s)=>{const o=new Array(e.length+1).fill(!1),c=new Array(e.length+1).fill(!1);let l=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-r-(t-1)*r,a[1][t]=0;a[0][0]=0;for(let d=1;d<s.length+1;d++){a[u][0]=-r-(d-1)*r;for(let h=1;h<e.length+1;h++){const p=a[l][h-1]+i[t[e.charCodeAt(h-1)]][t[s.charCodeAt(d-1)]],m=a[l][h]-(o[h]||1===d||d===s.length?r:n),f=a[u][h-1]-(c[h-1]||1===h||h===e.length?r:n);a[u][h]=Math.max(p,f,m),a[u][h]===p?(o[h]=!1,c[h]=!1):a[u][h]===f?(o[h]=!1,c[h]=!0):(o[h]=!0,c[h]=!1)}l=u,u=(u+1)%2}const d=Math.min(e.length,s.length);return(d-a[l][e.length])/d}},[o.MONOMER_CHEMICAL_DISTANCE]:r}},9039:(e,t,n)=>{"use strict";var r;n.d(t,{c:()=>r}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(r||(r={}))},8498:(e,t,n)=>{"use strict";var r,i,s,o,a,c,l;n.d(t,{EG:()=>a,Pn:()=>i,RR:()=>c,Wn:()=>l,aT:()=>s,m6:()=>o,xL:()=>r}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(r||(r={})),function(e){e.Euclidean="Euclidean"}(i||(i={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(s||(s={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(o||(o={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(c||(c={})),function(e){e.CommonItems="Common Items"}(l||(l={}))},2780:(e,t,n)=>{"use strict";n.d(t,{aT:()=>r.aT});var r=n(8498);n(9336)},9336:(e,t,n)=>{"use strict";var r=n(2787),i=n(944),s=n(6295),o=n(3629),a=n(6863),c=n(8498);const l={[c.Pn.Euclidean]:o.ou},u={[c.xL.Levenshtein]:r.I,[c.xL.JaroWinkler]:i.Vb,[c.xL.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let r=1;r<e.length;r++)n+=e[r]==t[r]?0:1;return n/e.length}},[c.xL.Onehot]:function(e,t){return e===t?0:1}},d={[c.aT.Tanimoto]:s.tO,[c.aT.Dice]:s.zn,[c.aT.Asymmetric]:s.gt,[c.aT.BraunBlanquet]:s.ij,[c.aT.Cosine]:s.lO,[c.aT.Kulczynski]:s.rR,[c.aT.McConnaughey]:s.lP,[c.aT.RogotGoldberg]:s.TK,[c.aT.Russel]:s.yK,[c.aT.Sokal]:s.Ii,[c.aT.Hamming]:s.be,[c.aT.Euclidean]:s.a4},h={[c.m6.TanimotoIntArray]:s.v_},p={[c.RR.Difference]:s.T6},m={[c.Wn.CommonItems]:s.Hr},f={[c.EG.Vector]:{[c.Pn.Euclidean]:l[c.Pn.Euclidean]},[c.EG.String]:{[c.xL.Levenshtein]:u[c.xL.Levenshtein],[c.xL.JaroWinkler]:u[c.xL.JaroWinkler],[c.xL.Manhattan]:u[c.xL.Manhattan],[c.xL.Onehot]:u[c.xL.Onehot]},[c.EG.BitArray]:{[c.aT.Tanimoto]:d[c.aT.Tanimoto],[c.aT.Dice]:d[c.aT.Dice],[c.aT.Asymmetric]:d[c.aT.Asymmetric],[c.aT.BraunBlanquet]:d[c.aT.BraunBlanquet],[c.aT.Cosine]:d[c.aT.Cosine],[c.aT.Kulczynski]:d[c.aT.Kulczynski],[c.aT.McConnaughey]:d[c.aT.McConnaughey],[c.aT.RogotGoldberg]:d[c.aT.RogotGoldberg],[c.aT.Russel]:d[c.aT.Russel],[c.aT.Sokal]:d[c.aT.Sokal]},[c.EG.MacroMolecule]:{[a.Z.HAMMING]:a.V[a.Z.HAMMING],[a.Z.LEVENSHTEIN]:a.V[a.Z.LEVENSHTEIN],[a.Z.NEEDLEMANN_WUNSCH]:a.V[a.Z.NEEDLEMANN_WUNSCH],[a.Z.MONOMER_CHEMICAL_DISTANCE]:a.V[a.Z.MONOMER_CHEMICAL_DISTANCE]},[c.EG.Number]:{[c.RR.Difference]:p[c.RR.Difference]},[c.EG.IntArray]:{[c.m6.TanimotoIntArray]:h[c.m6.TanimotoIntArray]},[c.EG.NumberArray]:{[c.Wn.CommonItems]:m[c.Wn.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},8774:(e,t,n)=>{"use strict";n.d(t,{A:()=>r});class r{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,i=r._createBuffer(n);if(t)for(let e=0;e<i.length;e++)i[e]=-1;this._data=i,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,r){if(e<t||e>n)throw new Error(`Argument ${r} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let r=0;r<n;r++)t[r]=e[r]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new r(e._length);n._length=e._length,n._data=r._createBuffer(n._length),n._version=0;const i=e.lengthInInts;for(let r=0;r<i;r++)n._data[r]=e._data[r]&t._data[r];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new r(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new r(e);for(let r=0;r<e;++r)n.setBit(r,t(r));return n._version=0,n}static fromString(e){return r.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new r(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new r(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let i=0,s=0;for(;t-s>=4;)n._data[i++]=255&e[s]|(255&e[s+1])<<8|(255&e[s+2])<<16|(255&e[s+3])<<24,s+=4;return t-s==3&&(n._data[i]=(255&e[s+2])<<16),t-s==2&&(n._data[i]|=(255&e[s+1])<<8),t-s==1&&(n._data[i]|=255&e[s]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new r(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,r=this.lengthInInts;for(let e=0;e<r;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,r=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(r)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,r=!0,i=!0){if(n&&i&&this.setAll(!t,!1),i)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(r)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let r=e;r<t;++r)n.push(this.getBit(r));return r.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let r=e;r<t;++r)n.push(this.getBit(r));return n}setRange(e,t,n,r=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const i=Math.min(e,t),s=Math.max(e,t);if(n)for(let e=i;e<=s;e++)this.setTrue(e);else for(let e=i;e<=s;e++)this.setFalse(e);return this.incrementVersion(r),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const r=this._length;this.setLength(this._length+t);for(let n=r-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let r=e;r<e+t;r++)this.setBit(r,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let r=-1;-1!=(r=e.findNext(r,!t));)this.setFast(n++,this.getBit(r));this._length=n,this._version++}return this}getBit(e){return!!(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=r._onBitCount[255&e];let n=this._data[t];const i=31&this._length;for(0!=i&&(n&=~(4294967295<<i));0!=n;n>>>=8)this._selectedCount+=r._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const i=this.lengthInInts;let s=0;for(;s<i-1;s++)for(let t=this._data[s]&e._data[s];0!=t;t>>>=8)n+=r._onBitCount[255&t];let o=this._data[s]&e._data[s];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)n+=r._onBitCount[255&o];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const i=this.lengthInInts;for(let s=Math.floor(e/32);s<i;s++){let i=t?this._data[s]:~this._data[s];if(0!=n)i&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==i)continue;for(let t=0;0!=i;t+=8,i>>>=8){const n=r._firstOnBit[255&i];if(n>=0)return(e=n+32*s+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let i=Math.floor(e/32);i>=0;i--){let e=t?this._data[i]:~this._data[i];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=r._lastOnBit[e>>>24];if(n>=0)return n+32*i+t}}return-1}}r._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),r._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),r._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(e,t,n)=>{"use strict";n.d(t,{Pl:()=>H,bk:()=>B,gM:()=>G,L1:()=>k,cb:()=>Y,E3:()=>L,J6:()=>O,Wj:()=>I,Xk:()=>R,N$:()=>F,t6:()=>N,PE:()=>M,rd:()=>$,Bl:()=>K,CN:()=>b});var r=n(4328),i=n(6082);n(9982);const s=i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,');s.columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var o=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function a(e,t,n,i,s,a,c,l,u=!0){return o(this,void 0,void 0,(function*(){let d=null;if(yield $(i,(n=>o(this,void 0,void 0,(function*(){let n=null;for(const r of e.viewers)r.type===t&&(n=r);if(!n)throw Error("Viewer hasn't been added");if(yield Promise.resolve(),a&&(yield a(n)),s){const t=null!=l?l:{};t.tv=e,t.viewer=n,d=yield s(t,u)}yield M(r.events.onViewerClosed,(()=>{L(n.subs.some((e=>!e.closed)),!1)}),(()=>n.close()),3e3)}))),(()=>o(this,void 0,void 0,(function*(){c?e.loadLayout(c):yield function(e,t,n){return o(this,void 0,void 0,(function*(){let r;return n?(r=yield e.dataFrame.plot.fromType(t),e.dockManager.dock(r)):r=e.addViewer(t),r}))}(e,t,n)}))),6e4,"TEST_EVENT_ASYNC"),d)return d}))}function c(e,t=!0){return o(this,void 0,void 0,(function*(){const n=e.tv.dataFrame,r=n.clone();Array.from(n.row(0).cells).forEach((e=>e.value=null));const i=n.rowCount<20?Math.floor(n.rowCount/2):10;n.rows.select((e=>e.idx>=0&&e.idx<i)),t&&(yield Y(50));for(let e=i;e<2*i;e++)n.filter.set(e,!1);t&&(yield Y(50)),n.currentRowIdx=1,n.columns.names().slice(0,Math.ceil(n.columns.length/2)).forEach((e=>n.columns.remove(e))),t&&(yield Y(100)),e.tv.dataFrame=r,yield Y(50)}))}function l(e,t=!0){return o(this,void 0,void 0,(function*(){const t=e.tv.dataFrame;setTimeout((()=>t.filter.set(0,!t.filter.get(0))),0)}))}function u(e,t=!0){return o(this,void 0,void 0,(function*(){let t,n;try{t=e.viewer.getOptions(!0).look}catch(e){throw new Error("Viewer's .getOptions() error.",{cause:e})}try{n=e.viewer.getProperties()}catch(e){throw new Error("Viewer's .getProperties() error.",{cause:e})}const r={};return Object.keys(t).filter((e=>"boolean"==typeof t[e])).forEach((e=>r[e]=!t[e])),n.filter((e=>null!==e.choices)).forEach((e=>r[e.name]=e.choices.find((n=>n!==t[e.name])))),e.viewer.setOptions(r),yield Y(300),{layout:e.tv.saveLayout(),savedProps:e.viewer.getOptions().look}}))}function d(e,t=!0){return o(this,void 0,void 0,(function*(){L(JSON.stringify(e.viewer.getOptions().look),JSON.stringify(e.savedProps))}))}var h=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};const p=3e4,m=108e5,f=console.log.bind(console),g=console.info.bind(console),y=console.warn.bind(console),w=console.error.bind(console),b={},v="Auto Tests",A="Demo",E="Detectors",C="Core",T={};let S;var _;!function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(_||(_={}));class P{constructor(e,t){this.catchUnhandled=!0,this.report=!1,void 0!==e&&(this.catchUnhandled=e),void 0!==t&&(this.report=t)}}class x{constructor(e,t,n,r){var i;this.category=e,this.name=t,null!=r||(r={}),null!==(i=r.timeout)&&void 0!==i||(r.timeout=p),this.options=r,this.test=()=>h(this,void 0,void 0,(function*(){return new Promise(((e,t)=>h(this,void 0,void 0,(function*(){let r="";try{r=yield n()}catch(e){t(e)}e(r)}))))}))}}function M(e,t,n,r=0,i="timeout"){return h(this,void 0,void 0,(function*(){return new Promise(((s,o)=>{const a=e.subscribe((e=>{try{t(e),s("OK")}catch(e){o(e)}finally{a.unsubscribe(),clearTimeout(c)}})),c=setTimeout((()=>{a.unsubscribe(),o(i)}),r);n()}))}))}function $(e,t,n,r=0,i="timeout"){return h(this,void 0,void 0,(function*(){return new Promise(((s,o)=>{const a=e.subscribe((e=>{t(e).then((()=>{s("OK")})).catch((e=>{o(e)})).finally((()=>{a.unsubscribe(),clearTimeout(c)}))})),c=setTimeout((()=>{a.unsubscribe(),o(i)}),r);n()}))}))}function N(e,t,n){null==b[S]&&(b[S]={}),null==b[S].tests&&(b[S].tests=[]),b[S].tests.push(new x(S,e,t,n))}function L(e,t=!0,n){if(n=n?`${n}, `:"",e!==t)throw new Error(`${n}Expected "${t}", got "${e}"`)}function I(e,t,n=.001,r){if(e===Number.POSITIVE_INFINITY&&t===Number.POSITIVE_INFINITY||e===Number.NEGATIVE_INFINITY&&t===Number.NEGATIVE_INFINITY||e===Number.NaN&&t===Number.NaN||isNaN(e)&&isNaN(t))return;const i=Math.abs(e-t)<n;if(L(i,!0,`${null!=r?r:""} (tolerance = ${n})`),!i)throw new Error(`Expected ${t}, got ${e} (tolerance = ${n})`)}function R(e,t){for(const[n,r]of Object.entries(t)){if(!e.hasOwnProperty(n))throw new Error(`Expected property "${n}" not found`);const t=e[n];if(t instanceof Array&&r instanceof Array)O(t,r);else if(t instanceof Object&&r instanceof Object)R(t,r);else if(Number.isFinite(t)&&Number.isFinite(r))I(t,r);else if(t!=r)throw new Error(`Expected (${r}) for key '${n}', got (${t})`)}}function O(e,t){const n=e.length,r=t.length;if(n!=r)throw new Error(`Arrays are of different length: actual array length is ${n} and expected array length is ${r}`);for(let r=0;r<n;r++)if(e[r]instanceof Array&&t[r]instanceof Array)O(e[r],t[r]);else if(e[r]instanceof Object&&t[r]instanceof Object)R(e[r],t[r]);else if(e[r]!=t[r])throw new Error(`Expected ${t[r]} at position ${r}, got ${e[r]}`)}function k(e,t,n){var r;S=e,t(),b[S]&&(b[S].clear=null===(r=null==n?void 0:n.clear)||void 0===r||r,b[S].timeout=null==n?void 0:n.timeout,b[S].benchmarks=null==n?void 0:n.benchmarks,b[S].stressTests=null==n?void 0:n.stressTests)}function G(e){null==b[S]&&(b[S]={}),b[S].before=e}function H(e){null==b[S]&&(b[S]={}),b[S].after=e}function D(e,t){return e.replace(new RegExp(t.name,"gi"),t.nqName)}function F(e){var t,n,o,a;return h(this,void 0,void 0,(function*(){const c=null===(n=null===(t=r.functions.getCurrentCall())||void 0===t?void 0:t.func)||void 0===n?void 0:n.package;yield function(e){var t,n,o,a;return h(this,void 0,void 0,(function*(){const c=e.id;if(T[c])return;const l=b;if(void 0!==l[v]||void 0!==l[A]||Object.keys(l).find((e=>e.startsWith(v)||e.startsWith(C))))return void(T[c]=!0);if("DevTools"===e.name)for(const e of window.dartTests){const r=e.name.split(/\s*\|\s*!/g);let i=null!==(t=r.pop())&&void 0!==t?t:e.name,s=r.length?C+": "+r.join(": "):C,c=i.split(" | ");i=c[c.length-1],c.unshift(s),c.pop(),s=c.join(": "),void 0===l[s]&&(l[s]={tests:[],clear:!0}),l[s].tests.push(new x(s,i,e.test,{isAggregated:!1,timeout:null!==(o=null===(n=e.options)||void 0===n?void 0:n.timeout)&&void 0!==o?o:p,skipReason:null===(a=e.options)||void 0===a?void 0:a.skipReason}))}const u=[],d=[],m=[],f=yield r.dapi.functions.filter(`package.id = "${c}"`).list(),g=new RegExp(/skip:\s*([^,\s]+)|wait:\s*(\d+)|cat:\s*([^,\s]+)|timeout:\s*(\d+)/g);for(const e of f){const t=e.options.test,n=e.options.demoPath;if(t&&Array.isArray(t)&&t.length)for(let n=0;n<t.length;n++){const s=t[n].matchAll(g),o={};Array.from(s).forEach((e=>{e[0].startsWith("skip")?o.skip=e[1]:e[0].startsWith("wait")?o.wait=parseInt(e[2]):e[0].startsWith("cat")?o.cat=e[3]:e[0].startsWith("timeout")&&(o.timeout=parseInt(e[4]))}));const a=new x(v,1===t.length?e.name:`${e.name} ${n+1}`,(()=>h(this,void 0,void 0,(function*(){const i=yield r.functions.eval(D(t[n],e));if(o.wait&&(yield Y(o.wait)),"boolean"==typeof i&&!i)throw`Failed: ${t[n]}, expected true, got ${i}`}))),{skipReason:o.skip,timeout:i.Test.isInBenchmark?o.benchmarkTimeout:o.timeout});if(o.cat){const e=v+": "+o.cat;a.category=e,void 0===l[e]&&(l[e]={tests:[],clear:!0}),l[e].tests.push(a)}else u.push(a)}if(n){const t=e.options.demoWait?parseInt(e.options.demoWait):void 0,n=new x(A,e.friendlyName,(()=>h(this,void 0,void 0,(function*(){r.shell.isInDemo=!0,void 0===r.shell.view(i.View.BROWSE)&&(r.shell.v=i.View.createByType(i.View.BROWSE)),yield Y(300),r.shell.clearLastError(),yield e.apply(),yield Y(t||2e3);const n=yield r.shell.lastError;if(n)throw new Error(n);r.shell.isInDemo=!1}))),{skipReason:e.options.demoSkip});d.push(n)}if(e.hasTag("semTypeDetector")){const t=new x(E,e.friendlyName,(()=>h(this,void 0,void 0,(function*(){const t=[];for(const n of s.clone().columns){const r=yield e.apply([n]);t.push(r||n.semType)}L(t.filter((e=>e)).length,1)}))),{skipReason:e.options.skipTest});m.push(t)}}T[c]=!0,u.length&&(l[v]={tests:u,clear:!0}),d.length&&(l[A]={tests:d,clear:!0}),m.length&&(l[E]={tests:m,clear:!1})}))}(c);const l=[];console.log("Running tests"),null!=e||(e={}),null!==(o=(a=e).testContext)&&void 0!==o||(a.testContext=new P),r.shell.clearLastError();const u=function(){const e=[];return console.log=(...t)=>{e.push(...t),f(...t)},console.info=(...t)=>{e.push(...t),g(...t)},console.warn=(...t)=>{e.push(...t),y(...t)},console.error=(...t)=>{e.push(...t),w(...t)},e}();(null==e?void 0:e.stressTest)?yield function(e){var t,n,r,s,o,a;return h(this,void 0,void 0,(function*(){let h=[];for(const[e,i]of Object.entries(b)){let e=null===(t=i.tests)||void 0===t?void 0:t.filter((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.stressTest}));i.stressTests&&(e=null===(n=i.tests)||void 0===n?void 0:n.filter((e=>{var t,n;return void 0===(null===(t=e.options)||void 0===t?void 0:t.stressTest)||!0===(null===(n=e.options)||void 0===n?void 0:n.stressTest)})));const o=null===(r=i.tests)||void 0===r?void 0:r.every((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.skipReason}));if(!o)for(let t of null!=e?e:[])null==(null===(s=t.options)||void 0===s?void 0:s.skipReason)&&h.push({test:t,value:i})}h=function(e){const t=e.slice();return t.sort((()=>Math.random()-.5)),t}(h);const p=[];for(let t of h){yield d(t.value.before,null!==(o=e.category)&&void 0!==o?o:"");let n=yield V(t.test,null==e?void 0:e.test,u,i.Test.isInBenchmark?t.value.benchmarkTimeout:t.value.timeout,c.name,e.verbose);n&&p.push(n),console.log(`Test: ${null==N?void 0:N.name}; result: ${n}`),yield d(t.value.after,null!==(a=e.category)&&void 0!==a?a:"")}l.push(...p)}))}(e):yield function(e,t){var n,s,o,a,p,m,b;return h(this,void 0,void 0,(function*(){try{for(const[h,g]of Object.entries(e)){if((null==t?void 0:t.category)&&!h.toLowerCase().startsWith(null==t?void 0:t.category.toLowerCase())||(null===(n=t.exclude)||void 0===n?void 0:n.some((e=>h.startsWith(e)))))continue;f(`Started ${h} category`);const e=null===(s=g.tests)||void 0===s?void 0:s.every((e=>{var t;return null===(t=e.options)||void 0===t?void 0:t.skipReason}));e||(g.beforeStatus=yield d(g.before,null!==(o=t.category)&&void 0!==o?o:""));const y=null!==(a=g.tests)&&void 0!==a?a:[],w=[];if(g.clear)for(let e=0;e<y.length;e++){y[e].options&&void 0===(null===(p=y[e].options)||void 0===p?void 0:p.benchmark)&&(y[e].options||(y[e].options={}),y[e].options.benchmark=null!==(m=g.benchmarks)&&void 0!==m&&m);let n=yield V(y[e],null==t?void 0:t.test,u,i.Test.isInBenchmark?g.benchmarkTimeout:g.timeout,c.name,t.verbose);n&&w.push(n),r.shell.closeAll(),i.Balloon.closeAll()}else for(let e=0;e<y.length;e++){let n=yield V(y[e],null==t?void 0:t.test,u,i.Test.isInBenchmark?g.benchmarkTimeout:g.timeout,c.name,t.verbose);n&&w.push(n)}const v=w.filter((e=>"skipped"!=e.result));e||(g.afterStatus=yield d(g.after,null!==(b=t.category)&&void 0!==b?b:"")),g.afterStatus&&v.push({date:(new Date).toISOString(),logs:"",category:h,name:"after",result:g.afterStatus,success:!1,ms:0,skipped:!1}),g.beforeStatus&&v.push({date:(new Date).toISOString(),logs:"",category:h,name:"before",result:g.beforeStatus,success:!1,ms:0,skipped:!1}),l.push(...v)}}finally{console.log=f,console.info=g,console.warn=y,console.error=w}if(t.testContext.catchUnhandled&&!i.Test.isInBenchmark){yield Y(1e3);const e=yield r.shell.lastError,t={logs:"",date:(new Date).toISOString(),category:"Unhandled exceptions",name:"Exception",result:null!=e?e:"",success:!e,ms:0,skipped:!1};l.push(t),t.package=c.name,null!=r.shell.reportTest?yield r.shell.reportTest("package",t):yield fetch(`${r.dapi.root}/log/tests/package`,{method:"POST",headers:{"Content-Type":"application/json"},credentials:"same-origin",body:JSON.stringify(t)})}}))}(b,e);for(let e of l)e.result=e.result.toString().replace(/"/g,"'"),null!=e.logs&&(e.logs=e.logs.toString().replace(/"/g,"'"));return l;function d(e,t){return h(this,void 0,void 0,(function*(){var n=void 0;try{void 0!==e&&(yield W((()=>h(this,void 0,void 0,(function*(){yield e()}))),1e5,`before ${t}: timeout error`))}catch(e){n=yield U(e)}return n}))}}))}function U(e){return h(this,void 0,void 0,(function*(){return`${e.toString()}\n${e.stack?yield i.Logger.translateStackTrace(e.stack):""}`}))}function V(e,t,n,s,o,a){var c,l,u,d,g,y,b,v;return h(this,void 0,void 0,(function*(){let h;n.length=0;let A="package";const E=null!=t&&e.name.toLowerCase()!==t.toLowerCase();let C=(null===(c=e.options)||void 0===c?void 0:c.skipReason)||E,T=E?"skipped":null===(l=e.options)||void 0===l?void 0:l.skipReason;if(i.Test.isInBenchmark&&!(null===(u=e.options)||void 0===u?void 0:u.benchmark))return void f(`SKIPPED: ${e.category} ${e.name} doesnt available in benchmark mode`);C||f(`Started ${e.category} ${e.name}`);const S=Date.now();try{if(C)h={date:(new Date).toISOString(),success:!0,result:T,ms:0,skipped:!0};else{let t=(null===(d=e.options)||void 0===d?void 0:d.timeout)===p&&s?s:null===(g=e.options)||void 0===g?void 0:g.timeout;t=t===p&&i.Test.isInBenchmark?m:t,h={date:(new Date).toISOString(),success:!0,result:null!==(y=yield W(e.test,t))&&void 0!==y?y:"OK",ms:0,skipped:!1}}}catch(e){w(e),h={date:(new Date).toISOString(),success:!1,result:yield U(e),ms:0,skipped:!1}}if((null===(b=e.options)||void 0===b?void 0:b.isAggregated)&&h.result.constructor===i.DataFrame){const e=h.result.col("success");if(e&&(h.success=e.stats.sum===e.length),!a){const e=h.result;e.columns.remove("stack"),e.rows.removeWhere((e=>e.get("success"))),h.result=e}h.result=h.result.toCsv()}if(h.logs=n.join("\n"),h.ms=Date.now()-S,C||f(`Finished ${e.category} ${e.name} for ${h.ms} ms`),h.category=e.category,h.name=e.name,!E){let t={success:h.success,result:h.result,ms:h.ms,skipped:h.skipped,package:o,category:e.category,name:e.name,logs:h.logs};if(h.result.constructor==Object){const e=Object.keys(h.result).reduce(((e,t)=>Object.assign(Object.assign({},e),{["result."+t]:h.result[t]})),{});t=Object.assign(Object.assign({},t),e)}t.result instanceof i.DataFrame&&(t.result=JSON.stringify(null===(v=t.result)||void 0===v?void 0:v.toJson())||""),null!=r.shell.reportTest?yield r.shell.reportTest(A,t):yield fetch(`${r.dapi.root}/log/tests/${A}`,{method:"POST",headers:{"Content-Type":"application/json"},credentials:"same-origin",body:JSON.stringify(t)})}return h}))}function Y(e){return h(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}function B(e,t="Timeout exceeded",n=500,r=50){return h(this,void 0,void 0,(function*(){return new Promise(((i,s)=>{setTimeout((()=>{clearInterval(o),s(new Error(t))}),n);const o=setInterval((()=>{e()&&(clearInterval(o),i())}),r)}))}))}function W(e,t,n="EXECUTION TIMEOUT"){return h(this,void 0,void 0,(function*(){let r=null;const i=new Promise(((e,i)=>{r=setTimeout((()=>{i(n)}),t)}));try{return yield Promise.race([e(),i])}finally{r&&clearTimeout(r)}}))}const j=i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])]);function K(e,t,n){var i;return h(this,void 0,void 0,(function*(){const s=null!==(i=null==n?void 0:n.packageName)&&void 0!==i?i:"";(null==n?void 0:n.detectSemanticTypes)&&(yield r.data.detectSemanticTypes(t));const o=r.shell.addTableView(t);try{yield a(o,e,s,r.events.onViewerAdded),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,void 0,n.awaitViewer)),(null==n?void 0:n.readOnly)||(yield a(o,e,s,r.events.onViewerAdded,c),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,c,n.awaitViewer)));let t=null;t=yield a(o,e,s,r.events.onViewerAdded,u),(null==n?void 0:n.awaitViewer)&&(t=yield a(o,e,s,r.events.onViewerAdded,u,n.awaitViewer)),yield a(o,e,s,r.events.onViewLayoutApplied,d,void 0,null==t?void 0:t.layout,{savedProps:null==t?void 0:t.savedProps}),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewLayoutApplied,d,n.awaitViewer,null==t?void 0:t.layout,{savedProps:null==t?void 0:t.savedProps})),!1!==(null==n?void 0:n.arbitraryDfTest)&&(o.dataFrame=j,yield Y(50),yield a(o,e,s,r.events.onViewerAdded),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,void 0,n.awaitViewer))),yield a(o,e,s,r.events.onViewerAdded,l),(null==n?void 0:n.awaitViewer)&&(yield a(o,e,s,r.events.onViewerAdded,l,n.awaitViewer))}finally{}}))}},3629:(e,t,n)=>{"use strict";function r(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function i(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function s(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let r=0;r<e.length;r++)n+=e[r]*t[r];return n}function o(e,t){let n=0;const r=e.length;if(r!==t.length)throw new Error("The dimensionality of the vectors must match");for(let i=0;i<r;++i)n+=Math.pow(e[i]-t[i],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,r=0;for(let i=0;i<t;++i)n+=e[i],r+=Math.pow(e[i],2);const i=n/t,s=1/Math.sqrt(r/t-Math.pow(i,2));for(let n=0;n<t;++n)e[n]=(e[n]-i)*s;return e}n.d(t,{KE:()=>s,S8:()=>a,ou:()=>o,vA:()=>r,wQ:()=>i})},1913:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3282),i=n(9029),s=n(1520),o=n(2586),a=n(8708),c=n(2023),l="errorMessage",u=new r.Name("emUsed"),d={required:"missingProperty",dependencies:"property",dependentRequired:"property"},h=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:l,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:w}=t;if(!1===w.createErrors)return;const b=g,v=i.strConcat(c.default.instancePath,w.errorPath);function A(e,t){return i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,r._`${e}.instancePath === ${v}`,r._`${e}.keyword in ${t}`,r._`${e}.schemaPath.indexOf(${w.errSchemaPath}) === 0`,r._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${w.errSchemaPath.length}))`)}function E(e,t){const r=[];for(const n in e){const e=t[n];h.test(e)&&r.push([n,T(e)])}return n.object(...r)}function C(e){return h.test(e)?new s._Code(s.safeStringify(e).replace(p,((e,t)=>`" + JSON.stringify(${o.getData(t,w)}) + "`)).replace(m,"")):r.stringify(e)}function T(e){return r._`function(){return ${C(e)}}`}n.if(r._`${c.default.errors} > 0`,(()=>{if("object"==typeof b){const[s,o]=function(e){let t,n;for(const r in e){if("properties"===r||"items"===r)continue;const i=e[r];if("object"==typeof i){t||(t={});const e=t[r]={};for(const t in i)e[t]=[]}else n||(n={}),n[r]=[]}return[t,n]}(b);o&&function(i){const s=n.const("emErrors",r.stringify(i)),o=n.const("templates",E(i,g));n.forOf("err",c.default.vErrors,(e=>n.if(A(e,s),(()=>n.code(r._`${s}[${e}.keyword].push(${e})`).assign(r._`${e}.${u}`,!0)))));const{singleError:l}=e;if(l){const e=n.let("message",r._`""`),i=n.let("paramsErrors",r._`[]`);d((t=>{n.if(e,(()=>n.code(r._`${e} += ${"string"==typeof l?l:";"}`))),n.code(r._`${e} += ${h(t)}`),n.assign(i,r._`${i}.concat(${s}[${t}])`)})),a.reportError(t,{message:e,params:r._`{errors: ${i}}`})}else d((e=>a.reportError(t,{message:h(e),params:r._`{errors: ${s}[${e}]}`})));function d(e){n.forIn("key",s,(t=>n.if(r._`${s}[${t}].length`,(()=>e(t)))))}function h(e){return r._`${e} in ${o} ? ${o}[${e}]() : ${y}[${e}]`}}(o),s&&function(e){const i=n.const("emErrors",r.stringify(e)),s=[];for(const t in e)s.push([t,E(e[t],g[t])]);const o=n.const("templates",n.object(...s)),l=n.scopeValue("obj",{ref:d,code:r.stringify(d)}),h=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",c.default.vErrors,(e=>n.if(A(e,i),(()=>{n.assign(h,r._`${l}[${e}.keyword]`),n.assign(p,r._`${i}[${e}.keyword][${e}.params[${h}]]`),n.if(p,(()=>n.code(r._`${p}.push(${e})`).assign(r._`${e}.${u}`,!0)))})))),n.forIn("key",i,(e=>n.forIn("keyProp",r._`${i}[${e}]`,(s=>{n.assign(p,r._`${i}[${e}][${s}]`),n.if(r._`${p}.length`,(()=>{const i=n.const("tmpl",r._`${o}[${e}] && ${o}[${e}][${s}]`);a.reportError(t,{message:r._`${i} ? ${i}() : ${y}[${e}][${s}]`,params:r._`{errors: ${p}}`})}))}))))}(s),function(e){const{props:s,items:o}=e;if(!s&&!o)return;const d=r._`typeof ${f} == "object"`,h=r._`Array.isArray(${f})`,p=n.let("emErrors");let m,w;const b=n.let("templates");function A(e,t){n.assign(p,r.stringify(e)),n.assign(b,E(e,t))}s&&o?(m=n.let("emChildKwd"),n.if(d),n.if(h,(()=>{A(o,g.items),n.assign(m,r.str`items`)}),(()=>{A(s,g.properties),n.assign(m,r.str`properties`)})),w=r._`[${m}]`):o?(n.if(h),A(o,g.items),w=r._`.items`):s&&(n.if(i.and(d,i.not(h))),A(s,g.properties),w=r._`.properties`),n.forOf("err",c.default.vErrors,(e=>function(e,t,s){n.if(i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,r._`${e}.instancePath.indexOf(${v}) === 0`),(()=>{const i=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:r._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),o=n.const("emMatches",r._`${i}.exec(${e}.instancePath.slice(${v}.length))`),a=n.const("emChild",r._`${o} && ${o}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(r._`${a} !== undefined && ${a} in ${t}`,(()=>s(a)))}))}(e,p,(t=>n.code(r._`${p}[${t}].push(${e})`).assign(r._`${e}.${u}`,!0))))),n.forIn("key",p,(e=>n.if(r._`${p}[${e}].length`,(()=>{a.reportError(t,{message:r._`${e} in ${b} ? ${b}[${e}]() : ${y}${w}[${e}]`,params:r._`{errors: ${p}[${e}]}`}),n.assign(r._`${c.default.vErrors}[${c.default.errors}-1].instancePath`,r._`${v} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(b))}const s="string"==typeof b?b:b._;s&&function(e){const s=n.const("emErrs",r._`[]`);n.forOf("err",c.default.vErrors,(e=>n.if(function(e){return i.and(r._`${e}.keyword !== ${l}`,r._`!${e}.${u}`,i.or(r._`${e}.instancePath === ${v}`,i.and(r._`${e}.instancePath.indexOf(${v}) === 0`,r._`${e}.instancePath[${v}.length] === "/"`)),r._`${e}.schemaPath.indexOf(${w.errSchemaPath}) === 0`,r._`${e}.schemaPath[${w.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(r._`${s}.push(${e})`).assign(r._`${e}.${u}`,!0))))),n.if(r._`${s}.length`,(()=>a.reportError(t,{message:C(e),params:r._`{errors: ${s}}`})))}(s),e.keepErrors||function(){const e=n.const("emErrs",r._`[]`);n.forOf("err",c.default.vErrors,(t=>n.if(r._`!${t}.${u}`,(()=>n.code(r._`${e}.push(${t})`))))),n.assign(c.default.vErrors,e).assign(c.default.errors,r._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},7433:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv2020=void 0;const r=n(4042),i=n(6105),s=n(6653),o=n(9572),a="https://json-schema.org/draft/2020-12/schema";class c extends r.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),i.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(s.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(o.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}t.Ajv2020=c,e.exports=t=c,e.exports.Ajv2020=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var l=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return l.KeywordCxt}});var u=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var d=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var h=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return h.default}})},3282:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv=void 0;const r=n(4042),i=n(6144),s=n(6653),o=n(2079),a=["/properties"],c="http://json-schema.org/draft-07/schema";class l extends r.default{_addVocabularies(){super._addVocabularies(),i.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(s.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(o,a):o;this.addMetaSchema(e,c,!1),this.refs["http://json-schema.org/schema"]=c}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(c)?c:void 0)}}t.Ajv=l,e.exports=t=l,e.exports.Ajv=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var u=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var d=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return d._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return d.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return d.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return d.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return d.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return d.CodeGen}});var h=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var p=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class r extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=r;class i extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof r&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function s(e,...t){const n=[e[0]];let r=0;for(;r<t.length;)c(n,t[r]),n.push(e[++r]);return new i(n)}t._Code=i,t.nil=new i(""),t._=s;const o=new i("+");function a(e,...t){const n=[u(e[0])];let r=0;for(;r<t.length;)n.push(o),c(n,t[r]),n.push(o,u(e[++r]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===o){const n=l(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new i(n)}function c(e,t){var n;t instanceof i?e.push(...t._items):t instanceof r?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function l(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof r||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof r?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=c,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new i(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new i(`.${e}`):s`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new i(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new i(e.toString())}},9029:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const r=n(1520),i=n(7845);var s=n(1520);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return s._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return s.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return s.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return s.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return s.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return s.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return s.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return s.Name}});var o=n(7845);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return o.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return o.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return o.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return o.varKinds}}),t.operators={GT:new r._Code(">"),GTE:new r._Code(">="),LT:new r._Code("<"),LTE:new r._Code("<="),EQ:new r._Code("==="),NEQ:new r._Code("!=="),NOT:new r._Code("!"),OR:new r._Code("||"),AND:new r._Code("&&"),ADD:new r._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class c extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?i.varKinds.var:this.varKind,r=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${r};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof r._CodeOrName?this.rhs.names:{}}}class l extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof r.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return $(this.lhs instanceof r.Name?{}:{...this.lhs.names},this.rhs)}}class u extends l{constructor(e,t,n,r){super(e,n,r),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class p extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class m extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof r._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let r=n.length;for(;r--;){const i=n[r];i.optimizeNames(e,t)||(L(e,i.names),n.splice(r,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>M(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class w extends g{}w.kind="else";class b extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new w(e):e}return t?!1===e?t instanceof b?t:t.nodes:this.nodes.length?this:new b(I(e),t instanceof b?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return $(e,this.condition),this.else&&M(e,this.else.names),e}}b.kind="if";class v extends g{}v.kind="for";class A extends v{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return M(super.names,this.iteration.names)}}class E extends v{constructor(e,t,n,r){super(),this.varKind=e,this.name=t,this.from=n,this.to=r}render(e){const t=e.es5?i.varKinds.var:this.varKind,{name:n,from:r,to:s}=this;return`for(${t} ${n}=${r}; ${n}<${s}; ${n}++)`+super.render(e)}get names(){const e=$(super.names,this.from);return $(e,this.to)}}class C extends v{constructor(e,t,n,r){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=r}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return M(super.names,this.iterable.names)}}class T extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}T.kind="func";class S extends f{render(e){return"return "+super.render(e)}}S.kind="return";class _ extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,r;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(r=this.finally)||void 0===r||r.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&M(e,this.catch.names),this.finally&&M(e,this.finally.names),e}}class P extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}P.kind="catch";class x extends g{render(e){return"finally"+super.render(e)}}function M(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function $(e,t){return t instanceof r._CodeOrName?M(e,t.names):e}function N(e,t,n){return e instanceof r.Name?s(e):(i=e)instanceof r._Code&&i._items.some((e=>e instanceof r.Name&&1===t[e.str]&&void 0!==n[e.str]))?new r._Code(e._items.reduce(((e,t)=>(t instanceof r.Name&&(t=s(t)),t instanceof r._Code?e.push(...t._items):e.push(t),e)),[])):e;var i;function s(e){const r=n[e.str];return void 0===r||1!==t[e.str]?e:(delete t[e.str],r)}}function L(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function I(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:r._`!${G(e)}`}x.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new i.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,r){const i=this._scope.toName(t);return void 0!==n&&r&&(this._constants[i.str]=n),this._leafNode(new c(e,i,n)),i}const(e,t,n){return this._def(i.varKinds.const,e,t,n)}let(e,t,n){return this._def(i.varKinds.let,e,t,n)}var(e,t,n){return this._def(i.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new l(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==r.nil&&this._leafNode(new m(e)),this}object(...e){const t=["{"];for(const[n,i]of e)t.length>1&&t.push(","),t.push(n),(n!==i||this.opts.es5)&&(t.push(":"),(0,r.addCodeArg)(t,i));return t.push("}"),new r._Code(t)}if(e,t,n){if(this._blockNode(new b(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new b(e))}else(){return this._elseNode(new w)}endIf(){return this._endBlockNode(b,w)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new A(e),t)}forRange(e,t,n,r,s=(this.opts.es5?i.varKinds.var:i.varKinds.let)){const o=this._scope.toName(e);return this._for(new E(s,o,t,n),(()=>r(o)))}forOf(e,t,n,s=i.varKinds.const){const o=this._scope.toName(e);if(this.opts.es5){const e=t instanceof r.Name?t:this.var("_arr",t);return this.forRange("_i",0,r._`${e}.length`,(t=>{this.var(o,r._`${e}[${t}]`),n(o)}))}return this._for(new C("of",s,o,t),(()=>n(o)))}forIn(e,t,n,s=(this.opts.es5?i.varKinds.var:i.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,r._`Object.keys(${t})`,n);const o=this._scope.toName(e);return this._for(new C("in",s,o,t),(()=>n(o)))}endFor(){return this._endBlockNode(v)}label(e){return this._leafNode(new d(e))}break(e){return this._leafNode(new h(e))}return(e){const t=new S;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(S)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const r=new _;if(this._blockNode(r),this.code(e),t){const e=this.name("e");this._currNode=r.catch=new P(e),t(e)}return n&&(this._currNode=r.finally=new x,this.code(n)),this._endBlockNode(P,x)}throw(e){return this._leafNode(new p(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=r.nil,n,i){return this._blockNode(new T(e,t,n)),i&&this.code(i).endFunc(),this}endFunc(){return this._endBlockNode(T)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof b))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=I;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===r.nil?n:n===r.nil?t:r._`${G(t)} ${e} ${G(n)}`}function G(e){return e instanceof r.Name?e:r._`(${e})`}t.or=function(...e){return e.reduce(O)}},7845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const r=n(1520);class i extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var s;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(s||(t.UsedValueState=s={})),t.varKinds={const:new r.Name("const"),let:new r.Name("let"),var:new r.Name("var")};class o{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof r.Name?e:this.name(e)}name(e){return new r.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=o;class a extends r.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=r._`.${new r.Name(t)}[${n}]`}}t.ValueScopeName=a;const c=r._`\n`;t.ValueScope=class extends o{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?c:r.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const r=this.toName(e),{prefix:i}=r,s=null!==(n=t.key)&&void 0!==n?n:t.ref;let o=this._values[i];if(o){const e=o.get(s);if(e)return e}else o=this._values[i]=new Map;o.set(s,r);const a=this._scope[i]||(this._scope[i]=[]),c=a.length;return a[c]=t.ref,r.setValue(t,{property:i,itemIndex:c}),r}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return r._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,o={},a){let c=r.nil;for(const l in e){const u=e[l];if(!u)continue;const d=o[l]=o[l]||new Map;u.forEach((e=>{if(d.has(e))return;d.set(e,s.Started);let o=n(e);if(o){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;c=r._`${c}${n} ${e} = ${o};${this.opts._n}`}else{if(!(o=null==a?void 0:a(e)))throw new i(e);c=r._`${c}${o}${this.opts._n}`}d.set(e,s.Completed)}))}return c}}},8708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const r=n(9029),i=n(4227),s=n(2023);function o(e,t){const n=e.const("err",t);e.if(r._`${s.default.vErrors} === null`,(()=>e.assign(s.default.vErrors,r._`[${n}]`)),r._`${s.default.vErrors}.push(${n})`),e.code(r._`${s.default.errors}++`)}function a(e,t){const{gen:n,validateName:i,schemaEnv:s}=e;s.$async?n.throw(r._`new ${e.ValidationError}(${t})`):(n.assign(r._`${i}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>r.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?r.str`"${e}" keyword must be ${t} ($data)`:r.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,i,s){const{it:c}=e,{gen:u,compositeRule:d,allErrors:h}=c,p=l(e,n,i);(null!=s?s:d||h)?o(u,p):a(c,r._`[${p}]`)},t.reportExtraError=function(e,n=t.keywordError,r){const{it:i}=e,{gen:c,compositeRule:u,allErrors:d}=i;o(c,l(e,n,r)),u||d||a(i,s.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(s.default.errors,t),e.if(r._`${s.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(r._`${s.default.vErrors}.length`,t)),(()=>e.assign(s.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:i,errsCount:o,it:a}){if(void 0===o)throw new Error("ajv implementation error");const c=e.name("err");e.forRange("i",o,s.default.errors,(o=>{e.const(c,r._`${s.default.vErrors}[${o}]`),e.if(r._`${c}.instancePath === undefined`,(()=>e.assign(r._`${c}.instancePath`,(0,r.strConcat)(s.default.instancePath,a.errorPath)))),e.assign(r._`${c}.schemaPath`,r.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(r._`${c}.schema`,n),e.assign(r._`${c}.data`,i))}))};const c={keyword:new r.Name("keyword"),schemaPath:new r.Name("schemaPath"),params:new r.Name("params"),propertyName:new r.Name("propertyName"),message:new r.Name("message"),schema:new r.Name("schema"),parentSchema:new r.Name("parentSchema")};function l(e,t,n){const{createErrors:i}=e.it;return!1===i?r._`{}`:function(e,t,n={}){const{gen:i,it:o}=e,a=[u(o,n),d(e,n)];return function(e,{params:t,message:n},i){const{keyword:o,data:a,schemaValue:l,it:u}=e,{opts:d,propertyName:h,topSchemaRef:p,schemaPath:m}=u;i.push([c.keyword,o],[c.params,"function"==typeof t?t(e):t||r._`{}`]),d.messages&&i.push([c.message,"function"==typeof n?n(e):n]),d.verbose&&i.push([c.schema,l],[c.parentSchema,r._`${p}${m}`],[s.default.data,a]),h&&i.push([c.propertyName,h])}(e,t,a),i.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?r.str`${e}${(0,i.getErrorPath)(t,i.Type.Str)}`:e;return[s.default.instancePath,(0,r.strConcat)(s.default.instancePath,n)]}function d({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:s}){let o=s?t:r.str`${t}/${e}`;return n&&(o=r.str`${o}${(0,i.getErrorPath)(n,i.Type.Str)}`),[c.schemaPath,o]}},3835:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const r=n(9029),i=n(3558),s=n(2023),o=n(6939),a=n(4227),c=n(2586);class l{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,o.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=h.call(this,e);if(t)return t;const n=(0,o.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:l}=this.opts.code,{ownProperties:u}=this.opts,d=new r.CodeGen(this.scope,{es5:a,lines:l,ownProperties:u});let p;e.$async&&(p=d.scopeValue("Error",{ref:i.default,code:r._`require("ajv/dist/runtime/validation_error").default`}));const m=d.scopeName("validate");e.validateName=m;const f={gen:d,allErrors:this.opts.allErrors,data:s.default.data,parentData:s.default.parentData,parentDataProperty:s.default.parentDataProperty,dataNames:[s.default.data],dataPathArr:[r.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:d.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,r.stringify)(e.schema)}:{ref:e.schema}),validateName:m,ValidationError:p,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:r.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:r._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,c.validateFunctionCode)(f),d.optimize(this.opts.code.optimize);const t=d.toString();g=`${d.scopeRefs(s.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${s.default.self}`,`${s.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:t,scopeValues:d._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof r.Name?void 0:e,items:t instanceof r.Name?void 0:t,dynamicProps:e instanceof r.Name,dynamicItems:t instanceof r.Name},n.source&&(n.source.evaluated=(0,r.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function d(e){return(0,o.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function h(e){for(const r of this._compilations)if(n=e,(t=r).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return r;var t,n}function p(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||m.call(this,e,t)}function m(e,t){const n=this.opts.uriResolver.parse(t),r=(0,o._getFullPath)(this.opts.uriResolver,n);let i=(0,o.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&r===i)return g.call(this,n,e);const s=(0,o.normalizeId)(r),a=this.refs[s]||this.schemas[s];if("string"==typeof a){const t=m.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),s===(0,o.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,r=t[n];return r&&(i=(0,o.resolveUrl)(this.opts.uriResolver,i,r)),new l({schema:t,schemaId:n,root:e,baseId:i})}return g.call(this,n,a)}}t.SchemaEnv=l,t.compileSchema=u,t.resolveRef=function(e,t,n){var r;n=(0,o.resolveUrl)(this.opts.uriResolver,t,n);const i=e.refs[n];if(i)return i;let s=p.call(this,e,n);if(void 0===s){const i=null===(r=e.localRefs)||void 0===r?void 0:r[n],{schemaId:o}=this.opts;i&&(s=new l({schema:i,schemaId:o,root:e,baseId:t}))}return void 0!==s?e.refs[n]=d.call(this,s):void 0},t.getCompilingSchema=h,t.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:r}){var i;if("/"!==(null===(i=e.fragment)||void 0===i?void 0:i[0]))return;for(const r of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(r)];if(void 0===e)return;const i="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(r)&&i&&(t=(0,o.resolveUrl)(this.opts.uriResolver,t,i))}let s;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,o.resolveUrl)(this.opts.uriResolver,t,n.$ref);s=m.call(this,r,e)}const{schemaId:c}=this.opts;return s=s||new l({schema:n,schemaId:c,root:r,baseId:t}),s.schema!==s.root.schema?s:void 0}},2023:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={data:new r.Name("data"),valCxt:new r.Name("valCxt"),instancePath:new r.Name("instancePath"),parentData:new r.Name("parentData"),parentDataProperty:new r.Name("parentDataProperty"),rootData:new r.Name("rootData"),dynamicAnchors:new r.Name("dynamicAnchors"),vErrors:new r.Name("vErrors"),errors:new r.Name("errors"),this:new r.Name("this"),self:new r.Name("self"),scope:new r.Name("scope"),json:new r.Name("json"),jsonPos:new r.Name("jsonPos"),jsonLen:new r.Name("jsonLen"),jsonPart:new r.Name("jsonPart")};t.default=i},4551:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(6939);class i extends Error{constructor(e,t,n,i){super(i||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,r.resolveUrl)(e,t,n),this.missingSchema=(0,r.normalizeId)((0,r.getFullPath)(e,this.missingRef))}}t.default=i},6939:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const r=n(4227),i=n(2017),s=n(7106),o=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!c(e):!!t&&l(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function c(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(c))return!0;if("object"==typeof n&&c(n))return!0}return!1}function l(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!o.has(n)&&("object"==typeof e[n]&&(0,r.eachItem)(e[n],(e=>t+=l(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=p(t));const r=e.parse(t);return d(e,r)}function d(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=d;const h=/#\/?$/;function p(e){return e?e.replace(h,""):""}t.normalizeId=p,t.resolveUrl=function(e,t,n){return n=p(n),e.resolve(t,n)};const m=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:r}=this.opts,o=p(e[n]||t),a={"":o},c=u(r,o,!1),l={},d=new Set;return s(e,{allKeys:!0},((e,t,r,i)=>{if(void 0===i)return;const s=c+t;let o=a[i];function u(t){const n=this.opts.uriResolver.resolve;if(t=p(o?n(o,t):t),d.has(t))throw f(t);d.add(t);let r=this.refs[t];return"string"==typeof r&&(r=this.refs[r]),"object"==typeof r?h(e,r.schema,t):t!==p(s)&&("#"===t[0]?(h(e,l[t],t),l[t]=e):this.refs[t]=s),t}function g(e){if("string"==typeof e){if(!m.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(o=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=o})),l;function h(e,t,n){if(void 0!==t&&!i(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},396:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},4227:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const r=n(9029),i=n(1520);function s(e,t=e.schema){const{opts:n,self:r}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const i=r.RULES.keywords;for(const n in t)i[n]||m(e,`unknown keyword: "${n}"`)}function o(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function c(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function l({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:i}){return(s,o,a,c)=>{const l=void 0===a?o:a instanceof r.Name?(o instanceof r.Name?e(s,o,a):t(s,o,a),a):o instanceof r.Name?(t(s,a,o),o):n(o,a);return c!==r.Name||l instanceof r.Name?l:i(s,l)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",r._`{}`);return void 0!==t&&d(e,n,t),n}function d(e,t,n){Object.keys(n).forEach((n=>e.assign(r._`${t}${(0,r.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(s(e,t),!o(t,e.self.RULES.all))},t.checkUnknownRules=s,t.schemaHasRules=o,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,i,s){if(!s){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return r._`${n}`}return r._`${e}${t}${(0,r.getProperty)(i)}`},t.unescapeFragment=function(e){return c(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=c,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:l({mergeNames:(e,t,n)=>e.if(r._`${n} !== true && ${t} !== undefined`,(()=>{e.if(r._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,r._`${n} || {}`).code(r._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(r._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,r._`${n} || {}`),d(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:l({mergeNames:(e,t,n)=>e.if(r._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,r._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(r._`${n} !== true`,(()=>e.assign(n,!0===t||r._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=d;const h={};var p;function m(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:h[t.code]||(h[t.code]=new i._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(p||(t.Type=p={})),t.getErrorPath=function(e,t,n){if(e instanceof r.Name){const i=t===p.Num;return n?i?r._`"[" + ${e} + "]"`:r._`"['" + ${e} + "']"`:i?r._`"/" + ${e}`:r._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,r.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=m},7887:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>r(e,t)))}function r(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},r){const i=t.RULES.types[r];return i&&!0!==i&&n(e,i)},t.shouldUseGroup=n,t.shouldUseRule=r},8727:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const r=n(8708),i=n(9029),s=n(2023),o={message:"boolean schema is false"};function a(e,t){const{gen:n,data:i}=e,s={gen:n,keyword:"false schema",data:i,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,r.reportError)(s,o,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:r}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(s.default.data):(t.assign(i._`${r}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:r}=e;!1===r?(n.var(t,!1),a(e)):n.var(t,!0)}},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const r=n(396),i=n(7887),s=n(8708),o=n(9029),a=n(4227);var c;function l(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(r.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(c||(t.DataType=c={})),t.getSchemaTypes=function(e){const t=l(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=l,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:r,opts:s}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,s.coerceTypes),l=t.length>0&&!(0===a.length&&1===t.length&&(0,i.schemaHasRulesForType)(e,t[0]));if(l){const i=h(t,r,s.strictNumbers,c.Wrong);n.if(i,(()=>{a.length?function(e,t,n){const{gen:r,data:i,opts:s}=e,a=r.let("dataType",o._`typeof ${i}`),c=r.let("coerced",o._`undefined`);"array"===s.coerceTypes&&r.if(o._`${a} == 'object' && Array.isArray(${i}) && ${i}.length == 1`,(()=>r.assign(i,o._`${i}[0]`).assign(a,o._`typeof ${i}`).if(h(t,i,s.strictNumbers),(()=>r.assign(c,i))))),r.if(o._`${c} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===s.coerceTypes)&&l(e);function l(e){switch(e){case"string":return void r.elseIf(o._`${a} == "number" || ${a} == "boolean"`).assign(c,o._`"" + ${i}`).elseIf(o._`${i} === null`).assign(c,o._`""`);case"number":return void r.elseIf(o._`${a} == "boolean" || ${i} === null
2
2
  || (${a} == "string" && ${i} && ${i} == +${i})`).assign(c,o._`+${i}`);case"integer":return void r.elseIf(o._`${a} === "boolean" || ${i} === null
3
3
  || (${a} === "string" && ${i} && ${i} == +${i} && !(${i} % 1))`).assign(c,o._`+${i}`);case"boolean":return void r.elseIf(o._`${i} === "false" || ${i} === 0 || ${i} === null`).assign(c,!1).elseIf(o._`${i} === "true" || ${i} === 1`).assign(c,!0);case"null":return r.elseIf(o._`${i} === "" || ${i} === 0 || ${i} === false`),void r.assign(c,null);case"array":r.elseIf(o._`${a} === "string" || ${a} === "number"
4
- || ${a} === "boolean" || ${i} === null`).assign(c,o._`[${i}]`)}}r.else(),m(e),r.endIf(),r.if(o._`${c} !== undefined`,(()=>{r.assign(i,c),function({gen:e,parentData:t,parentDataProperty:n},r){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${n}]`,r)))}(e,c)}))}(e,t,a):m(e)}))}return l};const u=new Set(["string","number","integer","boolean","null"]);function d(e,t,n,r=c.Correct){const i=r===c.Correct?o.operators.EQ:o.operators.NEQ;let s;switch(e){case"null":return o._`${t} ${i} null`;case"array":s=o._`Array.isArray(${t})`;break;case"object":s=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":s=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":s=a();break;default:return o._`typeof ${t} ${i} ${e}`}return r===c.Correct?s:(0,o.not)(s);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,n?o._`isFinite(${t})`:o.nil)}}function h(e,t,n,r){if(1===e.length)return d(e[0],t,n,r);let i;const s=(0,a.toHash)(e);if(s.array&&s.object){const e=o._`typeof ${t} != "object"`;i=s.null?e:o._`!${t} || ${e}`,delete s.null,delete s.array,delete s.object}else i=o.nil;s.number&&delete s.integer;for(const e in s)i=(0,o.and)(i,d(e,t,n,r));return i}t.checkDataType=d,t.checkDataTypes=h;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:r}=e,i=(0,a.schemaRefOrVal)(e,r,"type");return{gen:t,keyword:"type",data:n,schema:r.type,schemaCode:i,schemaValue:i,parentSchema:r,params:{},it:e}}(e);(0,s.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const r=n(9029),i=n(4227);function s(e,t,n){const{gen:s,compositeRule:o,data:a,opts:c}=e;if(void 0===n)return;const l=r._`${a}${(0,r.getProperty)(t)}`;if(o)return void(0,i.checkStrictMode)(e,`default is ignored for: ${l}`);let u=r._`${l} === undefined`;"empty"===c.useDefaults&&(u=r._`${u} || ${l} === null || ${l} === ""`),s.if(u,r._`${l} = ${(0,r.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:r}=e.schema;if("object"===t&&n)for(const t in n)s(e,t,n[t].default);else"array"===t&&Array.isArray(r)&&r.forEach(((t,n)=>s(e,n,t.default)))}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const r=n(8727),i=n(208),s=n(7887),o=n(208),a=n(7870),c=n(3673),l=n(4495),u=n(9029),d=n(2023),h=n(6939),p=n(4227),m=n(8708);function f({gen:e,validateName:t,schema:n,schemaEnv:r,opts:i},s){i.code.es5?e.func(t,u._`${d.default.data}, ${d.default.valCxt}`,r.$async,(()=>{e.code(u._`"use strict"; ${g(n,i)}`),function(e,t){e.if(d.default.valCxt,(()=>{e.var(d.default.instancePath,u._`${d.default.valCxt}.${d.default.instancePath}`),e.var(d.default.parentData,u._`${d.default.valCxt}.${d.default.parentData}`),e.var(d.default.parentDataProperty,u._`${d.default.valCxt}.${d.default.parentDataProperty}`),e.var(d.default.rootData,u._`${d.default.valCxt}.${d.default.rootData}`),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`${d.default.valCxt}.${d.default.dynamicAnchors}`)}),(()=>{e.var(d.default.instancePath,u._`""`),e.var(d.default.parentData,u._`undefined`),e.var(d.default.parentDataProperty,u._`undefined`),e.var(d.default.rootData,d.default.data),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`{}`)}))}(e,i),e.code(s)})):e.func(t,u._`${d.default.data}, ${function(e){return u._`{${d.default.instancePath}="", ${d.default.parentData}, ${d.default.parentDataProperty}, ${d.default.rootData}=${d.default.data}${e.dynamicRef?u._`, ${d.default.dynamicAnchors}={}`:u.nil}}={}`}(i)}`,r.$async,(()=>e.code(g(n,i)).code(s)))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function w(e){return"boolean"!=typeof e.schema}function b(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:r,self:i}=e;t.$ref&&r.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,i.RULES)&&i.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function v(e,t){if(e.opts.jtd)return E(e,[],!1,t);const n=(0,i.getSchemaTypes)(e.schema);E(e,n,!(0,i.coerceAndCheckDataType)(e,n),t)}function A({gen:e,schemaEnv:t,schema:n,errSchemaPath:r,opts:i}){const s=n.$comment;if(!0===i.$comment)e.code(u._`${d.default.self}.logger.log(${s})`);else if("function"==typeof i.$comment){const n=u.str`${r}/$comment`,i=e.scopeValue("root",{ref:t.root});e.code(u._`${d.default.self}.opts.$comment(${s}, ${n}, ${i}.schema)`)}}function E(e,t,n,r){const{gen:i,schema:a,data:c,allErrors:l,opts:h,self:m}=e,{RULES:f}=m;function g(p){(0,s.shouldUseGroup)(a,p)&&(p.type?(i.if((0,o.checkDataType)(p.type,c,h.strictNumbers)),C(e,p),1===t.length&&t[0]===p.type&&n&&(i.else(),(0,o.reportTypeError)(e)),i.endIf()):C(e,p),l||i.if(u._`${d.default.errors} === ${r||0}`))}!a.$ref||!h.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(h.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{T(e.dataTypes,t)||S(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const r of e.dataTypes)T(t,r)?n.push(r):t.includes("integer")&&"number"===r&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&S(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const r in n){const i=n[r];if("object"==typeof i&&(0,s.shouldUseRule)(e.schema,i)){const{type:n}=i.definition;n.length&&!n.some((e=>{return r=e,(n=t).includes(r)||"number"===r&&n.includes("integer");var n,r}))&&S(e,`missing type "${n.join(",")}" for keyword "${r}"`)}}}(e,e.dataTypes))}(e,t),i.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):i.block((()=>x(e,"$ref",f.all.$ref.definition)))}function C(e,t){const{gen:n,schema:r,opts:{useDefaults:i}}=e;i&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,s.shouldUseRule)(r,n)&&x(e,n.keyword,n.definition,t.type)}))}function T(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function S(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){w(e)&&(b(e),y(e))?function(e){const{schema:t,opts:n,gen:r}=e;f(e,(()=>{n.$comment&&t.$comment&&A(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),r.let(d.default.vErrors,null),r.let(d.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),v(e),function(e){const{gen:t,schemaEnv:n,validateName:r,ValidationError:i,opts:s}=e;n.$async?t.if(u._`${d.default.errors} === 0`,(()=>t.return(d.default.data)),(()=>t.throw(u._`new ${i}(${d.default.vErrors})`))):(t.assign(u._`${r}.errors`,d.default.vErrors),s.unevaluated&&function({gen:e,evaluated:t,props:n,items:r}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),r instanceof u.Name&&e.assign(u._`${t}.items`,r)}(e),t.return(u._`${d.default.errors} === 0`))}(e)}))}(e):f(e,(()=>(0,r.topBoolOrEmptySchema)(e)))};class _{constructor(e,t,n){if((0,c.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",$(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,c.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",d.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?m.reportExtraError:m.reportError)(this,this.def.error,t)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:r,schemaType:i,def:s}=this;n.if((0,u.or)(u._`${r} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(i.length||s.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:r,it:i}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,o.checkDataTypes)(e,t,i.opts.strictNumbers,o.DataType.Wrong)}`}return u.nil}(),function(){if(r.validateSchema){const n=e.scopeValue("validate$data",{ref:r.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,l.getSubschema)(this.it,e);(0,l.extendSubschemaData)(n,this.it,e),(0,l.extendSubschemaMode)(n,e);const i={...this.it,...n,items:void 0,props:void 0};return function(e,t){w(e)&&(b(e),y(e))?function(e,t){const{schema:n,gen:r,opts:i}=e;i.$comment&&n.$comment&&A(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,h.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const s=r.const("_errs",d.default.errors);v(e,s),r.var(t,u._`${s} === ${d.default.errors}`)}(e,t):(0,r.boolOrEmptySchema)(e,t)}(i,t),i}mergeEvaluated(e,t){const{it:n,gen:r}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=p.mergeEvaluated.props(r,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=p.mergeEvaluated.items(r,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:r}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return r.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function x(e,t,n,r){const i=new _(e,n,t);"code"in n?n.code(i,r):i.$data&&n.validate?(0,c.funcKeywordCode)(i,n):"macro"in n?(0,c.macroKeywordCode)(i,n):(n.compile||n.validate)&&(0,c.funcKeywordCode)(i,n)}t.KeywordCxt=_;const P=/^\/(?:[^~]|~0|~1)*$/,M=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function $(e,{dataLevel:t,dataNames:n,dataPathArr:r}){let i,s;if(""===e)return d.default.rootData;if("/"===e[0]){if(!P.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);i=e,s=d.default.rootData}else{const o=M.exec(e);if(!o)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+o[1];if(i=o[2],"#"===i){if(a>=t)throw new Error(c("property/index",a));return r[t-a]}if(a>t)throw new Error(c("data",a));if(s=n[t-a],!i)return s}let o=s;const a=i.split("/");for(const e of a)e&&(s=u._`${s}${(0,u.getProperty)((0,p.unescapeJsonPointer)(e))}`,o=u._`${o} && ${s}`);return o;function c(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=$},3673:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const r=n(9029),i=n(2023),s=n(5765),o=n(8708);function a(e){const{gen:t,data:n,it:i}=e;t.if(i.parentData,(()=>t.assign(n,r._`${i.parentData}[${i.parentDataProperty}]`)))}function c(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,r.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:i,schema:s,parentSchema:o,it:a}=e,l=t.macro.call(a.self,s,o,a),u=c(n,i,l);!1!==a.opts.validateSchema&&a.self.validateSchema(l,!0);const d=n.name("valid");e.subschema({schema:l,schemaPath:r.nil,errSchemaPath:`${a.errSchemaPath}/${i}`,topSchemaRef:u,compositeRule:!0},d),e.pass(d,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:l,keyword:u,schema:d,parentSchema:h,$data:p,it:m}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(m,t);const f=!p&&t.compile?t.compile.call(m.self,d,h,m):t.validate,g=c(l,u,f),y=l.let("valid");function w(n=(t.async?r._`await `:r.nil)){const o=m.opts.passContext?i.default.this:i.default.self,a=!("compile"in t&&!p||!1===t.schema);l.assign(y,r._`${n}${(0,s.callValidateCode)(e,g,o,a)}`,t.modifying)}function b(e){var n;l.if((0,r.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)w(),t.modifying&&a(e),b((()=>e.error()));else{const n=t.async?function(){const e=l.let("ruleErrs",null);return l.try((()=>w(r._`await `)),(t=>l.assign(y,!1).if(r._`${t} instanceof ${m.ValidationError}`,(()=>l.assign(e,r._`${t}.errors`)),(()=>l.throw(t))))),e}():function(){const e=r._`${g}.errors`;return l.assign(e,null),w(r.nil),e}();t.modifying&&a(e),b((()=>function(e,t){const{gen:n}=e;n.if(r._`Array.isArray(${t})`,(()=>{n.assign(i.default.vErrors,r._`${i.default.vErrors} === null ? ${t} : ${i.default.vErrors}.concat(${t})`).assign(i.default.errors,r._`${i.default.vErrors}.length`),(0,o.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:r},i,s){if(Array.isArray(i.keyword)?!i.keyword.includes(s):i.keyword!==s)throw new Error("ajv implementation error");const o=i.dependencies;if(null==o?void 0:o.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${s}: ${o.join(",")}`);if(i.validateSchema&&!i.validateSchema(e[s])){const e=`keyword "${s}" value is invalid at path "${r}": `+n.errorsText(i.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},4495:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const r=n(9029),i=n(4227);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:s,schemaPath:o,errSchemaPath:a,topSchemaRef:c}){if(void 0!==t&&void 0!==s)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const s=e.schema[t];return void 0===n?{schema:s,schemaPath:r._`${e.schemaPath}${(0,r.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:s[n],schemaPath:r._`${e.schemaPath}${(0,r.getProperty)(t)}${(0,r.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,i.escapeFragment)(n)}`}}if(void 0!==s){if(void 0===o||void 0===a||void 0===c)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:s,schemaPath:o,topSchemaRef:c,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:s,data:o,dataTypes:a,propertyName:c}){if(void 0!==o&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:l}=t;if(void 0!==n){const{errorPath:o,dataPathArr:a,opts:c}=t;u(l.let("data",r._`${t.data}${(0,r.getProperty)(n)}`,!0)),e.errorPath=r.str`${o}${(0,i.getErrorPath)(n,s,c.jsPropertySyntax)}`,e.parentDataProperty=r._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==o&&(u(o instanceof r.Name?o:l.let("data",o,!0)),void 0!==c&&(e.propertyName=c)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:r,createErrors:i,allErrors:s}){void 0!==r&&(e.compositeRule=r),void 0!==i&&(e.createErrors=i),void 0!==s&&(e.allErrors=s),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var r=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return r.KeywordCxt}});var i=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return i._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return i.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return i.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return i.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return i.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return i.CodeGen}});const s=n(3558),o=n(4551),a=n(396),c=n(3835),l=n(9029),u=n(6939),d=n(208),h=n(4227),p=n(3837),m=n(5944),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),w={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},b={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function v(e){var t,n,r,i,s,o,a,c,l,u,d,h,p,g,y,w,b,v,A,E,C,T,S,_,x;const P=e.strict,M=null===(t=e.code)||void 0===t?void 0:t.optimize,$=!0===M||void 0===M?1:M||0,N=null!==(r=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==r?r:f,L=null!==(i=e.uriResolver)&&void 0!==i?i:m.default;return{strictSchema:null===(o=null!==(s=e.strictSchema)&&void 0!==s?s:P)||void 0===o||o,strictNumbers:null===(c=null!==(a=e.strictNumbers)&&void 0!==a?a:P)||void 0===c||c,strictTypes:null!==(u=null!==(l=e.strictTypes)&&void 0!==l?l:P)&&void 0!==u?u:"log",strictTuples:null!==(h=null!==(d=e.strictTuples)&&void 0!==d?d:P)&&void 0!==h?h:"log",strictRequired:null!==(g=null!==(p=e.strictRequired)&&void 0!==p?p:P)&&void 0!==g&&g,code:e.code?{...e.code,optimize:$,regExp:N}:{optimize:$,regExp:N},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(w=e.loopEnum)&&void 0!==w?w:200,meta:null===(b=e.meta)||void 0===b||b,messages:null===(v=e.messages)||void 0===v||v,inlineRefs:null===(A=e.inlineRefs)||void 0===A||A,schemaId:null!==(E=e.schemaId)&&void 0!==E?E:"$id",addUsedSchema:null===(C=e.addUsedSchema)||void 0===C||C,validateSchema:null===(T=e.validateSchema)||void 0===T||T,validateFormats:null===(S=e.validateFormats)||void 0===S||S,unicodeRegExp:null===(_=e.unicodeRegExp)||void 0===_||_,int32range:null===(x=e.int32range)||void 0===x||x,uriResolver:L}}class A{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...v(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new l.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return P;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const r=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),E.call(this,w,e,"NOT SUPPORTED"),E.call(this,b,e,"DEPRECATED","warn"),this._metaOpts=x.call(this),e.formats&&S.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),T.call(this),e.validateFormats=r}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let r=p;"id"===n&&(r={...p},r.id=r.$id,delete r.$id),t&&e&&this.addMetaSchema(r,r[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const r=n(t);return"$async"in n||(this.errors=n.errors),r}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return r.call(this,e,t);async function r(e,t){await i.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||s.call(this,n)}async function i(e){e&&!this.getSchema(e)&&await r.call(this,{$ref:e},!0)}async function s(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof o.default))throw t;return a.call(this,t),await c.call(this,t.missingSchema),s.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function c(e){const n=await l.call(this,e);this.refs[e]||await i.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function l(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,r=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,r);return this}let i;if("object"==typeof e){const{schemaId:t}=this.opts;if(i=e[t],void 0!==i&&"string"!=typeof i)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||i),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,r,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const r=this.validate(n,e);if(!r&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return r}getSchema(e){let t;for(;"string"==typeof(t=C.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,r=new c.SchemaEnv({schema:{},schemaId:n});if(t=c.resolveSchema.call(this,r,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=C.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if($.call(this,n,t),!t)return(0,h.eachItem)(n,(e=>N.call(this,e))),this;I.call(this,t);const r={...t,type:(0,d.getJSONTypes)(t.type),schemaType:(0,d.getJSONTypes)(t.schemaType)};return(0,h.eachItem)(n,0===r.type.length?e=>N.call(this,e,r):e=>r.type.forEach((t=>N.call(this,e,r,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const r of t){const t=r.split("/").slice(1);let i=e;for(const e of t)i=i[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:r}=t.definition,s=i[e];r&&s&&(i[e]=O(s))}}return e}_removeAllSchemas(e,t){for(const n in e){const r=e[n];t&&!t.test(n)||("string"==typeof r?delete e[n]:r&&!r.meta&&(this._cache.delete(r.schema),delete e[n]))}}_addSchema(e,t,n,r=this.opts.validateSchema,i=this.opts.addUsedSchema){let s;const{schemaId:o}=this.opts;if("object"==typeof e)s=e[o];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(s||n);const l=u.getSchemaRefs.call(this,e,n);return a=new c.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:n,localRefs:l}),this._cache.set(a.schema,a),i&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),r&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):c.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{c.compileSchema.call(this,e)}finally{this.opts=t}}}function E(e,t,n,r="error"){for(const i in e){const s=i;s in t&&this.logger[r](`${n}: option ${i}. ${e[s]}`)}}function C(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function T(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function S(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function _(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function x(){const e={...this.opts};for(const t of g)delete e[t];return e}A.ValidationError=s.default,A.MissingRefError=o.default,t.default=A;const P={log(){},warn(){},error(){}},M=/^[a-z_$][a-z0-9_$:-]*$/i;function $(e,t){const{RULES:n}=this;if((0,h.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!M.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function N(e,t,n){var r;const i=null==t?void 0:t.post;if(n&&i)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:s}=this;let o=i?s.post:s.rules.find((({type:e})=>e===n));if(o||(o={type:n,rules:[]},s.rules.push(o)),s.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,d.getJSONTypes)(t.type),schemaType:(0,d.getJSONTypes)(t.schemaType)}};t.before?L.call(this,o,a,t.before):o.rules.push(a),s.all[e]=a,null===(r=t.implements)||void 0===r||r.forEach((e=>this.addKeyword(e)))}function L(e,t,n){const r=e.rules.findIndex((e=>e.keyword===n));r>=0?e.rules.splice(r,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function I(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=O(t)),e.validateSchema=this.compile(t,!0))}const R={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(e){return{anyOf:[e,R]}}},9572:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(1678),i=n(7216),s=n(9547),o=n(8226),a=n(518),c=n(4588),l=n(5707),u=n(7082),d=["/properties"];t.default=function(e){return[r,i,s,o,a,t(this,c),l,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,d):n}}},6250:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2017);r.code='require("ajv/dist/runtime/equal").default',t.default=r},3853:(e,t)=>{"use strict";function n(e){const t=e.length;let n,r=0,i=0;for(;i<t;)r++,n=e.charCodeAt(i++),n>=55296&&n<=56319&&i<t&&(n=e.charCodeAt(i),56320==(64512&n)&&i++);return r}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(8343);r.code='require("ajv/dist/runtime/uri").default',t.default=r},3558:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},5457:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const r=n(9029),i=n(4227),s={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:r}=t;Array.isArray(r)?o(e,r):(0,i.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function o(e,t){const{gen:n,schema:s,data:o,keyword:a,it:c}=e;c.items=!0;const l=n.const("len",r._`${o}.length`);if(!1===s)e.setParams({len:t.length}),e.pass(r._`${l} <= ${t.length}`);else if("object"==typeof s&&!(0,i.alwaysValidSchema)(c,s)){const s=n.var("valid",r._`${l} <= ${t.length}`);n.if((0,r.not)(s),(()=>function(s){n.forRange("i",t.length,l,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:i.Type.Num},s),c.allErrors||n.if((0,r.not)(s),(()=>n.break()))}))}(s))),e.ok(s)}}t.validateAdditionalItems=o,t.default=s},8660:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(2023),o=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>i._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:c,errsCount:l,it:u}=e;if(!l)throw new Error("ajv implementation error");const{allErrors:d,opts:h}=u;if(u.props=!0,"all"!==h.removeAdditional&&(0,o.alwaysValidSchema)(u,n))return;const p=(0,r.allSchemaProperties)(a.properties),m=(0,r.allSchemaProperties)(a.patternProperties);function f(e){t.code(i._`delete ${c}[${e}]`)}function g(r){if("all"===h.removeAdditional||h.removeAdditional&&!1===n)f(r);else{if(!1===n)return e.setParams({additionalProperty:r}),e.error(),void(d||t.break());if("object"==typeof n&&!(0,o.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===h.removeAdditional?(y(r,n,!1),t.if((0,i.not)(n),(()=>{e.reset(),f(r)}))):(y(r,n),d||t.if((0,i.not)(n),(()=>t.break())))}}}function y(t,n,r){const i={keyword:"additionalProperties",dataProp:t,dataPropType:o.Type.Str};!1===r&&Object.assign(i,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(i,n)}t.forIn("key",c,(n=>{p.length||m.length?t.if(function(n){let s;if(p.length>8){const e=(0,o.schemaRefOrVal)(u,a.properties,"properties");s=(0,r.isOwnProperty)(t,e,n)}else s=p.length?(0,i.or)(...p.map((e=>i._`${n} === ${e}`))):i.nil;return m.length&&(s=(0,i.or)(s,...m.map((t=>i._`${(0,r.usePattern)(e,t)}.test(${n})`)))),(0,i.not)(s)}(n),(()=>g(n))):g(n)})),e.ok(i._`${l} === ${s.default.errors}`)}};t.default=a},5844:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:i}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const s=t.name("valid");n.forEach(((t,n)=>{if((0,r.alwaysValidSchema)(i,t))return;const o=e.subschema({keyword:"allOf",schemaProp:n},s);e.ok(s),e.mergeEvaluated(o)}))}};t.default=i},6505:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=r},2661:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?r.str`must contain at least ${e} valid item(s)`:r.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?r._`{minContains: ${e}}`:r._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:s,data:o,it:a}=e;let c,l;const{minContains:u,maxContains:d}=s;a.opts.next?(c=void 0===u?1:u,l=d):c=1;const h=t.const("len",r._`${o}.length`);if(e.setParams({min:c,max:l}),void 0===l&&0===c)return void(0,i.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==l&&c>l)return(0,i.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,i.alwaysValidSchema)(a,n)){let t=r._`${h} >= ${c}`;return void 0!==l&&(t=r._`${t} && ${h} <= ${l}`),void e.pass(t)}a.items=!0;const p=t.name("valid");function m(){const e=t.name("_valid"),n=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(r._`${e}++`),void 0===l?t.if(r._`${e} >= ${c}`,(()=>t.assign(p,!0).break())):(t.if(r._`${e} > ${l}`,(()=>t.assign(p,!1).break())),1===c?t.assign(p,!0):t.if(r._`${e} >= ${c}`,(()=>t.assign(p,!0))))}(n)))))}function f(n,r){t.forRange("i",0,h,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:i.Type.Num,compositeRule:!0},n),r()}))}void 0===l&&1===c?f(p,(()=>t.if(p,(()=>t.break())))):0===c?(t.let(p,!0),void 0!==l&&t.if(r._`${o}.length > 0`,m)):(t.let(p,!1),m()),e.result(p,(()=>e.reset()))}};t.default=s},3025:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const r=n(9029),i=n(4227),s=n(5765);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const i=1===t?"property":"properties";return r.str`must have ${i} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:i}})=>r._`{property: ${e},
4
+ || ${a} === "boolean" || ${i} === null`).assign(c,o._`[${i}]`)}}r.else(),m(e),r.endIf(),r.if(o._`${c} !== undefined`,(()=>{r.assign(i,c),function({gen:e,parentData:t,parentDataProperty:n},r){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${n}]`,r)))}(e,c)}))}(e,t,a):m(e)}))}return l};const u=new Set(["string","number","integer","boolean","null"]);function d(e,t,n,r=c.Correct){const i=r===c.Correct?o.operators.EQ:o.operators.NEQ;let s;switch(e){case"null":return o._`${t} ${i} null`;case"array":s=o._`Array.isArray(${t})`;break;case"object":s=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":s=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":s=a();break;default:return o._`typeof ${t} ${i} ${e}`}return r===c.Correct?s:(0,o.not)(s);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,n?o._`isFinite(${t})`:o.nil)}}function h(e,t,n,r){if(1===e.length)return d(e[0],t,n,r);let i;const s=(0,a.toHash)(e);if(s.array&&s.object){const e=o._`typeof ${t} != "object"`;i=s.null?e:o._`!${t} || ${e}`,delete s.null,delete s.array,delete s.object}else i=o.nil;s.number&&delete s.integer;for(const e in s)i=(0,o.and)(i,d(e,t,n,r));return i}t.checkDataType=d,t.checkDataTypes=h;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:r}=e,i=(0,a.schemaRefOrVal)(e,r,"type");return{gen:t,keyword:"type",data:n,schema:r.type,schemaCode:i,schemaValue:i,parentSchema:r,params:{},it:e}}(e);(0,s.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const r=n(9029),i=n(4227);function s(e,t,n){const{gen:s,compositeRule:o,data:a,opts:c}=e;if(void 0===n)return;const l=r._`${a}${(0,r.getProperty)(t)}`;if(o)return void(0,i.checkStrictMode)(e,`default is ignored for: ${l}`);let u=r._`${l} === undefined`;"empty"===c.useDefaults&&(u=r._`${u} || ${l} === null || ${l} === ""`),s.if(u,r._`${l} = ${(0,r.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:r}=e.schema;if("object"===t&&n)for(const t in n)s(e,t,n[t].default);else"array"===t&&Array.isArray(r)&&r.forEach(((t,n)=>s(e,n,t.default)))}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const r=n(8727),i=n(208),s=n(7887),o=n(208),a=n(7870),c=n(3673),l=n(4495),u=n(9029),d=n(2023),h=n(6939),p=n(4227),m=n(8708);function f({gen:e,validateName:t,schema:n,schemaEnv:r,opts:i},s){i.code.es5?e.func(t,u._`${d.default.data}, ${d.default.valCxt}`,r.$async,(()=>{e.code(u._`"use strict"; ${g(n,i)}`),function(e,t){e.if(d.default.valCxt,(()=>{e.var(d.default.instancePath,u._`${d.default.valCxt}.${d.default.instancePath}`),e.var(d.default.parentData,u._`${d.default.valCxt}.${d.default.parentData}`),e.var(d.default.parentDataProperty,u._`${d.default.valCxt}.${d.default.parentDataProperty}`),e.var(d.default.rootData,u._`${d.default.valCxt}.${d.default.rootData}`),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`${d.default.valCxt}.${d.default.dynamicAnchors}`)}),(()=>{e.var(d.default.instancePath,u._`""`),e.var(d.default.parentData,u._`undefined`),e.var(d.default.parentDataProperty,u._`undefined`),e.var(d.default.rootData,d.default.data),t.dynamicRef&&e.var(d.default.dynamicAnchors,u._`{}`)}))}(e,i),e.code(s)})):e.func(t,u._`${d.default.data}, ${function(e){return u._`{${d.default.instancePath}="", ${d.default.parentData}, ${d.default.parentDataProperty}, ${d.default.rootData}=${d.default.data}${e.dynamicRef?u._`, ${d.default.dynamicAnchors}={}`:u.nil}}={}`}(i)}`,r.$async,(()=>e.code(g(n,i)).code(s)))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function w(e){return"boolean"!=typeof e.schema}function b(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:r,self:i}=e;t.$ref&&r.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,i.RULES)&&i.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function v(e,t){if(e.opts.jtd)return E(e,[],!1,t);const n=(0,i.getSchemaTypes)(e.schema);E(e,n,!(0,i.coerceAndCheckDataType)(e,n),t)}function A({gen:e,schemaEnv:t,schema:n,errSchemaPath:r,opts:i}){const s=n.$comment;if(!0===i.$comment)e.code(u._`${d.default.self}.logger.log(${s})`);else if("function"==typeof i.$comment){const n=u.str`${r}/$comment`,i=e.scopeValue("root",{ref:t.root});e.code(u._`${d.default.self}.opts.$comment(${s}, ${n}, ${i}.schema)`)}}function E(e,t,n,r){const{gen:i,schema:a,data:c,allErrors:l,opts:h,self:m}=e,{RULES:f}=m;function g(p){(0,s.shouldUseGroup)(a,p)&&(p.type?(i.if((0,o.checkDataType)(p.type,c,h.strictNumbers)),C(e,p),1===t.length&&t[0]===p.type&&n&&(i.else(),(0,o.reportTypeError)(e)),i.endIf()):C(e,p),l||i.if(u._`${d.default.errors} === ${r||0}`))}!a.$ref||!h.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(h.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{T(e.dataTypes,t)||S(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const r of e.dataTypes)T(t,r)?n.push(r):t.includes("integer")&&"number"===r&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&S(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const r in n){const i=n[r];if("object"==typeof i&&(0,s.shouldUseRule)(e.schema,i)){const{type:n}=i.definition;n.length&&!n.some((e=>{return r=e,(n=t).includes(r)||"number"===r&&n.includes("integer");var n,r}))&&S(e,`missing type "${n.join(",")}" for keyword "${r}"`)}}}(e,e.dataTypes))}(e,t),i.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):i.block((()=>P(e,"$ref",f.all.$ref.definition)))}function C(e,t){const{gen:n,schema:r,opts:{useDefaults:i}}=e;i&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,s.shouldUseRule)(r,n)&&P(e,n.keyword,n.definition,t.type)}))}function T(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function S(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){w(e)&&(b(e),y(e))?function(e){const{schema:t,opts:n,gen:r}=e;f(e,(()=>{n.$comment&&t.$comment&&A(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),r.let(d.default.vErrors,null),r.let(d.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),v(e),function(e){const{gen:t,schemaEnv:n,validateName:r,ValidationError:i,opts:s}=e;n.$async?t.if(u._`${d.default.errors} === 0`,(()=>t.return(d.default.data)),(()=>t.throw(u._`new ${i}(${d.default.vErrors})`))):(t.assign(u._`${r}.errors`,d.default.vErrors),s.unevaluated&&function({gen:e,evaluated:t,props:n,items:r}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),r instanceof u.Name&&e.assign(u._`${t}.items`,r)}(e),t.return(u._`${d.default.errors} === 0`))}(e)}))}(e):f(e,(()=>(0,r.topBoolOrEmptySchema)(e)))};class _{constructor(e,t,n){if((0,c.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",$(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,c.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",d.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?m.reportExtraError:m.reportError)(this,this.def.error,t)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:r,schemaType:i,def:s}=this;n.if((0,u.or)(u._`${r} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(i.length||s.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:r,it:i}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,o.checkDataTypes)(e,t,i.opts.strictNumbers,o.DataType.Wrong)}`}return u.nil}(),function(){if(r.validateSchema){const n=e.scopeValue("validate$data",{ref:r.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,l.getSubschema)(this.it,e);(0,l.extendSubschemaData)(n,this.it,e),(0,l.extendSubschemaMode)(n,e);const i={...this.it,...n,items:void 0,props:void 0};return function(e,t){w(e)&&(b(e),y(e))?function(e,t){const{schema:n,gen:r,opts:i}=e;i.$comment&&n.$comment&&A(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,h.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const s=r.const("_errs",d.default.errors);v(e,s),r.var(t,u._`${s} === ${d.default.errors}`)}(e,t):(0,r.boolOrEmptySchema)(e,t)}(i,t),i}mergeEvaluated(e,t){const{it:n,gen:r}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=p.mergeEvaluated.props(r,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=p.mergeEvaluated.items(r,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:r}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return r.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function P(e,t,n,r){const i=new _(e,n,t);"code"in n?n.code(i,r):i.$data&&n.validate?(0,c.funcKeywordCode)(i,n):"macro"in n?(0,c.macroKeywordCode)(i,n):(n.compile||n.validate)&&(0,c.funcKeywordCode)(i,n)}t.KeywordCxt=_;const x=/^\/(?:[^~]|~0|~1)*$/,M=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function $(e,{dataLevel:t,dataNames:n,dataPathArr:r}){let i,s;if(""===e)return d.default.rootData;if("/"===e[0]){if(!x.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);i=e,s=d.default.rootData}else{const o=M.exec(e);if(!o)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+o[1];if(i=o[2],"#"===i){if(a>=t)throw new Error(c("property/index",a));return r[t-a]}if(a>t)throw new Error(c("data",a));if(s=n[t-a],!i)return s}let o=s;const a=i.split("/");for(const e of a)e&&(s=u._`${s}${(0,u.getProperty)((0,p.unescapeJsonPointer)(e))}`,o=u._`${o} && ${s}`);return o;function c(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=$},3673:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const r=n(9029),i=n(2023),s=n(5765),o=n(8708);function a(e){const{gen:t,data:n,it:i}=e;t.if(i.parentData,(()=>t.assign(n,r._`${i.parentData}[${i.parentDataProperty}]`)))}function c(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,r.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:i,schema:s,parentSchema:o,it:a}=e,l=t.macro.call(a.self,s,o,a),u=c(n,i,l);!1!==a.opts.validateSchema&&a.self.validateSchema(l,!0);const d=n.name("valid");e.subschema({schema:l,schemaPath:r.nil,errSchemaPath:`${a.errSchemaPath}/${i}`,topSchemaRef:u,compositeRule:!0},d),e.pass(d,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:l,keyword:u,schema:d,parentSchema:h,$data:p,it:m}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(m,t);const f=!p&&t.compile?t.compile.call(m.self,d,h,m):t.validate,g=c(l,u,f),y=l.let("valid");function w(n=(t.async?r._`await `:r.nil)){const o=m.opts.passContext?i.default.this:i.default.self,a=!("compile"in t&&!p||!1===t.schema);l.assign(y,r._`${n}${(0,s.callValidateCode)(e,g,o,a)}`,t.modifying)}function b(e){var n;l.if((0,r.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)w(),t.modifying&&a(e),b((()=>e.error()));else{const n=t.async?function(){const e=l.let("ruleErrs",null);return l.try((()=>w(r._`await `)),(t=>l.assign(y,!1).if(r._`${t} instanceof ${m.ValidationError}`,(()=>l.assign(e,r._`${t}.errors`)),(()=>l.throw(t))))),e}():function(){const e=r._`${g}.errors`;return l.assign(e,null),w(r.nil),e}();t.modifying&&a(e),b((()=>function(e,t){const{gen:n}=e;n.if(r._`Array.isArray(${t})`,(()=>{n.assign(i.default.vErrors,r._`${i.default.vErrors} === null ? ${t} : ${i.default.vErrors}.concat(${t})`).assign(i.default.errors,r._`${i.default.vErrors}.length`),(0,o.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:r},i,s){if(Array.isArray(i.keyword)?!i.keyword.includes(s):i.keyword!==s)throw new Error("ajv implementation error");const o=i.dependencies;if(null==o?void 0:o.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${s}: ${o.join(",")}`);if(i.validateSchema&&!i.validateSchema(e[s])){const e=`keyword "${s}" value is invalid at path "${r}": `+n.errorsText(i.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},4495:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const r=n(9029),i=n(4227);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:s,schemaPath:o,errSchemaPath:a,topSchemaRef:c}){if(void 0!==t&&void 0!==s)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const s=e.schema[t];return void 0===n?{schema:s,schemaPath:r._`${e.schemaPath}${(0,r.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:s[n],schemaPath:r._`${e.schemaPath}${(0,r.getProperty)(t)}${(0,r.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,i.escapeFragment)(n)}`}}if(void 0!==s){if(void 0===o||void 0===a||void 0===c)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:s,schemaPath:o,topSchemaRef:c,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:s,data:o,dataTypes:a,propertyName:c}){if(void 0!==o&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:l}=t;if(void 0!==n){const{errorPath:o,dataPathArr:a,opts:c}=t;u(l.let("data",r._`${t.data}${(0,r.getProperty)(n)}`,!0)),e.errorPath=r.str`${o}${(0,i.getErrorPath)(n,s,c.jsPropertySyntax)}`,e.parentDataProperty=r._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==o&&(u(o instanceof r.Name?o:l.let("data",o,!0)),void 0!==c&&(e.propertyName=c)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:r,createErrors:i,allErrors:s}){void 0!==r&&(e.compositeRule=r),void 0!==i&&(e.createErrors=i),void 0!==s&&(e.allErrors=s),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var r=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return r.KeywordCxt}});var i=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return i._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return i.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return i.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return i.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return i.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return i.CodeGen}});const s=n(3558),o=n(4551),a=n(396),c=n(3835),l=n(9029),u=n(6939),d=n(208),h=n(4227),p=n(3837),m=n(5944),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),w={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},b={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function v(e){var t,n,r,i,s,o,a,c,l,u,d,h,p,g,y,w,b,v,A,E,C,T,S,_,P;const x=e.strict,M=null===(t=e.code)||void 0===t?void 0:t.optimize,$=!0===M||void 0===M?1:M||0,N=null!==(r=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==r?r:f,L=null!==(i=e.uriResolver)&&void 0!==i?i:m.default;return{strictSchema:null===(o=null!==(s=e.strictSchema)&&void 0!==s?s:x)||void 0===o||o,strictNumbers:null===(c=null!==(a=e.strictNumbers)&&void 0!==a?a:x)||void 0===c||c,strictTypes:null!==(u=null!==(l=e.strictTypes)&&void 0!==l?l:x)&&void 0!==u?u:"log",strictTuples:null!==(h=null!==(d=e.strictTuples)&&void 0!==d?d:x)&&void 0!==h?h:"log",strictRequired:null!==(g=null!==(p=e.strictRequired)&&void 0!==p?p:x)&&void 0!==g&&g,code:e.code?{...e.code,optimize:$,regExp:N}:{optimize:$,regExp:N},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(w=e.loopEnum)&&void 0!==w?w:200,meta:null===(b=e.meta)||void 0===b||b,messages:null===(v=e.messages)||void 0===v||v,inlineRefs:null===(A=e.inlineRefs)||void 0===A||A,schemaId:null!==(E=e.schemaId)&&void 0!==E?E:"$id",addUsedSchema:null===(C=e.addUsedSchema)||void 0===C||C,validateSchema:null===(T=e.validateSchema)||void 0===T||T,validateFormats:null===(S=e.validateFormats)||void 0===S||S,unicodeRegExp:null===(_=e.unicodeRegExp)||void 0===_||_,int32range:null===(P=e.int32range)||void 0===P||P,uriResolver:L}}class A{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...v(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new l.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return x;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const r=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),E.call(this,w,e,"NOT SUPPORTED"),E.call(this,b,e,"DEPRECATED","warn"),this._metaOpts=P.call(this),e.formats&&S.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),T.call(this),e.validateFormats=r}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let r=p;"id"===n&&(r={...p},r.id=r.$id,delete r.$id),t&&e&&this.addMetaSchema(r,r[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const r=n(t);return"$async"in n||(this.errors=n.errors),r}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return r.call(this,e,t);async function r(e,t){await i.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||s.call(this,n)}async function i(e){e&&!this.getSchema(e)&&await r.call(this,{$ref:e},!0)}async function s(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof o.default))throw t;return a.call(this,t),await c.call(this,t.missingSchema),s.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function c(e){const n=await l.call(this,e);this.refs[e]||await i.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function l(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,r=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,r);return this}let i;if("object"==typeof e){const{schemaId:t}=this.opts;if(i=e[t],void 0!==i&&"string"!=typeof i)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||i),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,r,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const r=this.validate(n,e);if(!r&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return r}getSchema(e){let t;for(;"string"==typeof(t=C.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,r=new c.SchemaEnv({schema:{},schemaId:n});if(t=c.resolveSchema.call(this,r,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=C.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if($.call(this,n,t),!t)return(0,h.eachItem)(n,(e=>N.call(this,e))),this;I.call(this,t);const r={...t,type:(0,d.getJSONTypes)(t.type),schemaType:(0,d.getJSONTypes)(t.schemaType)};return(0,h.eachItem)(n,0===r.type.length?e=>N.call(this,e,r):e=>r.type.forEach((t=>N.call(this,e,r,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const r of t){const t=r.split("/").slice(1);let i=e;for(const e of t)i=i[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:r}=t.definition,s=i[e];r&&s&&(i[e]=O(s))}}return e}_removeAllSchemas(e,t){for(const n in e){const r=e[n];t&&!t.test(n)||("string"==typeof r?delete e[n]:r&&!r.meta&&(this._cache.delete(r.schema),delete e[n]))}}_addSchema(e,t,n,r=this.opts.validateSchema,i=this.opts.addUsedSchema){let s;const{schemaId:o}=this.opts;if("object"==typeof e)s=e[o];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(s||n);const l=u.getSchemaRefs.call(this,e,n);return a=new c.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:n,localRefs:l}),this._cache.set(a.schema,a),i&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),r&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):c.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{c.compileSchema.call(this,e)}finally{this.opts=t}}}function E(e,t,n,r="error"){for(const i in e){const s=i;s in t&&this.logger[r](`${n}: option ${i}. ${e[s]}`)}}function C(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function T(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function S(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function _(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function P(){const e={...this.opts};for(const t of g)delete e[t];return e}A.ValidationError=s.default,A.MissingRefError=o.default,t.default=A;const x={log(){},warn(){},error(){}},M=/^[a-z_$][a-z0-9_$:-]*$/i;function $(e,t){const{RULES:n}=this;if((0,h.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!M.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function N(e,t,n){var r;const i=null==t?void 0:t.post;if(n&&i)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:s}=this;let o=i?s.post:s.rules.find((({type:e})=>e===n));if(o||(o={type:n,rules:[]},s.rules.push(o)),s.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,d.getJSONTypes)(t.type),schemaType:(0,d.getJSONTypes)(t.schemaType)}};t.before?L.call(this,o,a,t.before):o.rules.push(a),s.all[e]=a,null===(r=t.implements)||void 0===r||r.forEach((e=>this.addKeyword(e)))}function L(e,t,n){const r=e.rules.findIndex((e=>e.keyword===n));r>=0?e.rules.splice(r,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function I(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=O(t)),e.validateSchema=this.compile(t,!0))}const R={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(e){return{anyOf:[e,R]}}},9572:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(1678),i=n(7216),s=n(9547),o=n(8226),a=n(518),c=n(4588),l=n(5707),u=n(7082),d=["/properties"];t.default=function(e){return[r,i,s,o,a,t(this,c),l,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,d):n}}},6250:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2017);r.code='require("ajv/dist/runtime/equal").default',t.default=r},3853:(e,t)=>{"use strict";function n(e){const t=e.length;let n,r=0,i=0;for(;i<t;)r++,n=e.charCodeAt(i++),n>=55296&&n<=56319&&i<t&&(n=e.charCodeAt(i),56320==(64512&n)&&i++);return r}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(8343);r.code='require("ajv/dist/runtime/uri").default',t.default=r},3558:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},5457:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const r=n(9029),i=n(4227),s={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:r}=t;Array.isArray(r)?o(e,r):(0,i.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function o(e,t){const{gen:n,schema:s,data:o,keyword:a,it:c}=e;c.items=!0;const l=n.const("len",r._`${o}.length`);if(!1===s)e.setParams({len:t.length}),e.pass(r._`${l} <= ${t.length}`);else if("object"==typeof s&&!(0,i.alwaysValidSchema)(c,s)){const s=n.var("valid",r._`${l} <= ${t.length}`);n.if((0,r.not)(s),(()=>function(s){n.forRange("i",t.length,l,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:i.Type.Num},s),c.allErrors||n.if((0,r.not)(s),(()=>n.break()))}))}(s))),e.ok(s)}}t.validateAdditionalItems=o,t.default=s},8660:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(2023),o=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>i._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:c,errsCount:l,it:u}=e;if(!l)throw new Error("ajv implementation error");const{allErrors:d,opts:h}=u;if(u.props=!0,"all"!==h.removeAdditional&&(0,o.alwaysValidSchema)(u,n))return;const p=(0,r.allSchemaProperties)(a.properties),m=(0,r.allSchemaProperties)(a.patternProperties);function f(e){t.code(i._`delete ${c}[${e}]`)}function g(r){if("all"===h.removeAdditional||h.removeAdditional&&!1===n)f(r);else{if(!1===n)return e.setParams({additionalProperty:r}),e.error(),void(d||t.break());if("object"==typeof n&&!(0,o.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===h.removeAdditional?(y(r,n,!1),t.if((0,i.not)(n),(()=>{e.reset(),f(r)}))):(y(r,n),d||t.if((0,i.not)(n),(()=>t.break())))}}}function y(t,n,r){const i={keyword:"additionalProperties",dataProp:t,dataPropType:o.Type.Str};!1===r&&Object.assign(i,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(i,n)}t.forIn("key",c,(n=>{p.length||m.length?t.if(function(n){let s;if(p.length>8){const e=(0,o.schemaRefOrVal)(u,a.properties,"properties");s=(0,r.isOwnProperty)(t,e,n)}else s=p.length?(0,i.or)(...p.map((e=>i._`${n} === ${e}`))):i.nil;return m.length&&(s=(0,i.or)(s,...m.map((t=>i._`${(0,r.usePattern)(e,t)}.test(${n})`)))),(0,i.not)(s)}(n),(()=>g(n))):g(n)})),e.ok(i._`${l} === ${s.default.errors}`)}};t.default=a},5844:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:i}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const s=t.name("valid");n.forEach(((t,n)=>{if((0,r.alwaysValidSchema)(i,t))return;const o=e.subschema({keyword:"allOf",schemaProp:n},s);e.ok(s),e.mergeEvaluated(o)}))}};t.default=i},6505:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=r},2661:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?r.str`must contain at least ${e} valid item(s)`:r.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?r._`{minContains: ${e}}`:r._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:s,data:o,it:a}=e;let c,l;const{minContains:u,maxContains:d}=s;a.opts.next?(c=void 0===u?1:u,l=d):c=1;const h=t.const("len",r._`${o}.length`);if(e.setParams({min:c,max:l}),void 0===l&&0===c)return void(0,i.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==l&&c>l)return(0,i.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,i.alwaysValidSchema)(a,n)){let t=r._`${h} >= ${c}`;return void 0!==l&&(t=r._`${t} && ${h} <= ${l}`),void e.pass(t)}a.items=!0;const p=t.name("valid");function m(){const e=t.name("_valid"),n=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(r._`${e}++`),void 0===l?t.if(r._`${e} >= ${c}`,(()=>t.assign(p,!0).break())):(t.if(r._`${e} > ${l}`,(()=>t.assign(p,!1).break())),1===c?t.assign(p,!0):t.if(r._`${e} >= ${c}`,(()=>t.assign(p,!0))))}(n)))))}function f(n,r){t.forRange("i",0,h,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:i.Type.Num,compositeRule:!0},n),r()}))}void 0===l&&1===c?f(p,(()=>t.if(p,(()=>t.break())))):0===c?(t.let(p,!0),void 0!==l&&t.if(r._`${o}.length > 0`,m)):(t.let(p,!1),m()),e.result(p,(()=>e.reset()))}};t.default=s},3025:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const r=n(9029),i=n(4227),s=n(5765);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const i=1===t?"property":"properties";return r.str`must have ${i} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:i}})=>r._`{property: ${e},
5
5
  missingProperty: ${i},
6
6
  depsCount: ${t},
7
- deps: ${n}}`};const o={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const r in e)"__proto__"!==r&&((Array.isArray(e[r])?t:n)[r]=e[r]);return[t,n]}(e);a(e,t),c(e,n)}};function a(e,t=e.schema){const{gen:n,data:i,it:o}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const c in t){const l=t[c];if(0===l.length)continue;const u=(0,s.propertyInData)(n,i,c,o.opts.ownProperties);e.setParams({property:c,depsCount:l.length,deps:l.join(", ")}),o.allErrors?n.if(u,(()=>{for(const t of l)(0,s.checkReportMissingProp)(e,t)})):(n.if(r._`${u} && (${(0,s.checkMissingProp)(e,l,a)})`),(0,s.reportMissingProp)(e,a),n.else())}}function c(e,t=e.schema){const{gen:n,data:r,keyword:o,it:a}=e,c=n.name("valid");for(const l in t)(0,i.alwaysValidSchema)(a,t[l])||(n.if((0,s.propertyInData)(n,r,l,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:o,schemaProp:l},c);e.mergeValidEvaluated(t,c)}),(()=>n.var(c,!0))),e.ok(c))}t.validatePropertyDeps=a,t.validateSchemaDeps=c,t.default=o},4845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3025),i={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,r.validateSchemaDeps)(e)};t.default=i},1239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>r.str`must match "${e.ifClause}" schema`,params:({params:e})=>r._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:s}=e;void 0===n.then&&void 0===n.else&&(0,i.checkStrictMode)(s,'"if" without "then" and "else" is ignored');const a=o(s,"then"),c=o(s,"else");if(!a&&!c)return;const l=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&c){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,d("then",n),d("else",n))}else a?t.if(u,d("then")):t.if((0,r.not)(u),d("else"));function d(n,i){return()=>{const s=e.subschema({keyword:n},u);t.assign(l,u),e.mergeValidEvaluated(s,l),i?t.assign(i,r._`${n}`):e.setParams({ifClause:n})}}e.pass(l,(()=>e.error(!0)))}};function o(e,t){const n=e.schema[t];return void 0!==n&&!(0,i.alwaysValidSchema)(e,n)}t.default=s},6378:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5457),i=n(5354),s=n(494),o=n(3966),a=n(2661),c=n(3025),l=n(9713),u=n(8660),d=n(117),h=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),w=n(4426);t.default=function(e=!1){const t=[p.default,m.default,f.default,g.default,y.default,w.default,l.default,u.default,c.default,d.default,h.default];return e?t.push(i.default,o.default):t.push(r.default,s.default),t.push(a.default),t}},494:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const r=n(9029),i=n(4227),s=n(5765),o={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,i.alwaysValidSchema)(n,t)||e.ok((0,s.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:s,parentSchema:o,data:a,keyword:c,it:l}=e;!function(e){const{opts:r,errSchemaPath:s}=l,o=n.length,a=o===e.minItems&&(o===e.maxItems||!1===e[t]);if(r.strictTuples&&!a){const e=`"${c}" is ${o}-tuple, but minItems or maxItems/${t} are not specified or different at path "${s}"`;(0,i.checkStrictMode)(l,e,r.strictTuples)}}(o),l.opts.unevaluated&&n.length&&!0!==l.items&&(l.items=i.mergeEvaluated.items(s,n.length,l.items));const u=s.name("valid"),d=s.const("len",r._`${a}.length`);n.forEach(((t,n)=>{(0,i.alwaysValidSchema)(l,t)||(s.if(r._`${d} > ${n}`,(()=>e.subschema({keyword:c,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=o},3966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(5765),o=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:r}=e,{prefixItems:a}=n;r.items=!0,(0,i.alwaysValidSchema)(r,t)||(a?(0,o.validateAdditionalItems)(e,a):e.ok((0,s.validateArray)(e)))}};t.default=a},7923:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:i}=e;if((0,r.alwaysValidSchema)(i,n))return void e.fail();const s=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},s),e.failResult(s,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=i},6163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>r._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:s,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(o.opts.discriminator&&s.discriminator)return;const a=n,c=t.let("valid",!1),l=t.let("passing",null),u=t.name("_valid");e.setParams({passing:l}),t.block((function(){a.forEach(((n,s)=>{let a;(0,i.alwaysValidSchema)(o,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:s,compositeRule:!0},u),s>0&&t.if(r._`${u} && ${c}`).assign(c,!1).assign(l,r._`[${l}, ${s}]`).else(),t.if(u,(()=>{t.assign(c,!0),t.assign(l,s),a&&e.mergeEvaluated(a,r.Name)}))}))})),e.result(c,(()=>e.reset()),(()=>e.error(!0)))}};t.default=s},5333:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(4227),o=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:c,it:l}=e,{opts:u}=l,d=(0,r.allSchemaProperties)(n),h=d.filter((e=>(0,s.alwaysValidSchema)(l,n[e])));if(0===d.length||h.length===d.length&&(!l.opts.unevaluated||!0===l.props))return;const p=u.strictSchema&&!u.allowMatchingProperties&&c.properties,m=t.name("valid");!0===l.props||l.props instanceof i.Name||(l.props=(0,o.evaluatedPropsToName)(t,l.props));const{props:f}=l;function g(e){for(const t in p)new RegExp(e).test(t)&&(0,s.checkStrictMode)(l,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(s=>{t.if(i._`${(0,r.usePattern)(e,n)}.test(${s})`,(()=>{const r=h.includes(n);r||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:s,dataPropType:o.Type.Str},m),l.opts.unevaluated&&!0!==f?t.assign(i._`${f}[${s}]`,!0):r||l.allErrors||t.if((0,i.not)(m),(()=>t.break()))}))}))}!function(){for(const e of d)p&&g(e),l.allErrors?y(e):(t.var(m,!0),y(e),t.if(m))}()}};t.default=a},5354:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(494),i={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,r.validateTuple)(e,"items")};t.default=i},117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2586),i=n(5765),s=n(4227),o=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:c,it:l}=e;"all"===l.opts.removeAdditional&&void 0===a.additionalProperties&&o.default.code(new r.KeywordCxt(l,o.default,"additionalProperties"));const u=(0,i.allSchemaProperties)(n);for(const e of u)l.definedProperties.add(e);l.opts.unevaluated&&u.length&&!0!==l.props&&(l.props=s.mergeEvaluated.props(t,(0,s.toHash)(u),l.props));const d=u.filter((e=>!(0,s.alwaysValidSchema)(l,n[e])));if(0===d.length)return;const h=t.name("valid");for(const n of d)p(n)?m(n):(t.if((0,i.propertyInData)(t,c,n,l.opts.ownProperties)),m(n),l.allErrors||t.else().var(h,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(h);function p(e){return l.opts.useDefaults&&!l.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},h)}}};t.default=a},9713:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>r._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:s,it:o}=e;if((0,i.alwaysValidSchema)(o,n))return;const a=t.name("valid");t.forIn("key",s,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,r.not)(a),(()=>{e.error(!0),o.allErrors||t.break()}))})),e.ok(a)}};t.default=s},4426:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,r.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=i},5765:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const r=n(9029),i=n(4227),s=n(2023),o=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:r._`Object.prototype.hasOwnProperty`})}function c(e,t,n){return r._`${a(e)}.call(${t}, ${n})`}function l(e,t,n,i){const s=r._`${t}${(0,r.getProperty)(n)} === undefined`;return i?(0,r.or)(s,(0,r.not)(c(e,t,n))):s}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:i,it:s}=e;n.if(l(n,i,t,s.opts.ownProperties),(()=>{e.setParams({missingProperty:r._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},i,s){return(0,r.or)(...i.map((i=>(0,r.and)(l(e,t,i,n.ownProperties),r._`${s} = ${i}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=c,t.propertyInData=function(e,t,n,i){const s=r._`${t}${(0,r.getProperty)(n)} !== undefined`;return i?r._`${s} && ${c(e,t,n)}`:s},t.noPropertyInData=l,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,i.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:i,schemaPath:o,errorPath:a},it:c},l,u,d){const h=d?r._`${e}, ${t}, ${i}${o}`:t,p=[[s.default.instancePath,(0,r.strConcat)(s.default.instancePath,a)],[s.default.parentData,c.parentData],[s.default.parentDataProperty,c.parentDataProperty],[s.default.rootData,s.default.rootData]];c.opts.dynamicRef&&p.push([s.default.dynamicAnchors,s.default.dynamicAnchors]);const m=r._`${h}, ${n.object(...p)}`;return u!==r.nil?r._`${l}.call(${u}, ${m})`:r._`${l}(${m})`};const d=r._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const i=t.unicodeRegExp?"u":"",{regExp:s}=t.code,a=s(n,i);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:r._`${"new RegExp"===s.code?d:(0,o.useFunc)(e,s)}(${n}, ${i})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:s,it:o}=e,a=t.name("valid");if(o.allErrors){const e=t.let("valid",!0);return c((()=>t.assign(e,!1))),e}return t.var(a,!0),c((()=>t.break())),a;function c(o){const c=t.const("len",r._`${n}.length`);t.forRange("i",0,c,(n=>{e.subschema({keyword:s,dataProp:n,dataPropType:i.Type.Num},a),t.if((0,r.not)(a),o)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:s,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,i.alwaysValidSchema)(o,e)))&&!o.opts.unevaluated)return;const a=t.let("valid",!1),c=t.name("_valid");t.block((()=>n.forEach(((n,i)=>{const o=e.subschema({keyword:s,schemaProp:i,compositeRule:!0},c);t.assign(a,r._`${a} || ${c}`),e.mergeValidEvaluated(o,c)||t.if((0,r.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},3463:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3463),i=n(3693),s=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",r.default,i.default];t.default=s},3693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const r=n(4551),i=n(5765),s=n(9029),o=n(2023),a=n(3835),c=n(4227),l={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:i}=e,{baseId:o,schemaEnv:c,validateName:l,opts:h,self:p}=i,{root:m}=c;if(("#"===n||"#/"===n)&&o===m.baseId)return function(){if(c===m)return d(e,l,c,c.$async);const n=t.scopeValue("root",{ref:m});return d(e,s._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,o,n);if(void 0===f)throw new r.default(i.opts.uriResolver,o,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);d(e,n,t,t.$async)}(f):function(r){const i=t.scopeValue("schema",!0===h.code.source?{ref:r,code:(0,s.stringify)(r)}:{ref:r}),o=t.name("valid"),a=e.subschema({schema:r,dataTypes:[],schemaPath:s.nil,topSchemaRef:i,errSchemaPath:n},o);e.mergeEvaluated(a),e.ok(o)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):s._`${n.scopeValue("wrapper",{ref:t})}.validate`}function d(e,t,n,r){const{gen:a,it:l}=e,{allErrors:u,schemaEnv:d,opts:h}=l,p=h.passContext?o.default.this:s.nil;function m(e){const t=s._`${e}.errors`;a.assign(o.default.vErrors,s._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`),a.assign(o.default.errors,s._`${o.default.vErrors}.length`)}function f(e){var t;if(!l.opts.unevaluated)return;const r=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==l.props)if(r&&!r.dynamicProps)void 0!==r.props&&(l.props=c.mergeEvaluated.props(a,r.props,l.props));else{const t=a.var("props",s._`${e}.evaluated.props`);l.props=c.mergeEvaluated.props(a,t,l.props,s.Name)}if(!0!==l.items)if(r&&!r.dynamicItems)void 0!==r.items&&(l.items=c.mergeEvaluated.items(a,r.items,l.items));else{const t=a.var("items",s._`${e}.evaluated.items`);l.items=c.mergeEvaluated.items(a,t,l.items,s.Name)}}r?function(){if(!d.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(s._`await ${(0,i.callValidateCode)(e,t,p)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(s._`!(${e} instanceof ${l.ValidationError})`,(()=>a.throw(e))),m(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,i.callValidateCode)(e,t,p),(()=>f(t)),(()=>m(t)))}t.getValidate=u,t.callRef=d,t.default=l},6653:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(7652),s=n(3835),o=n(4551),a=n(4227),c={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===i.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>r._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:c,parentSchema:l,it:u}=e,{oneOf:d}=l;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const h=c.propertyName;if("string"!=typeof h)throw new Error("discriminator: requires propertyName");if(c.mapping)throw new Error("discriminator: mapping is not supported");if(!d)throw new Error("discriminator: requires oneOf keyword");const p=t.let("valid",!1),m=t.const("tag",r._`${n}${(0,r.getProperty)(h)}`);function f(n){const i=t.name("valid"),s=e.subschema({keyword:"oneOf",schemaProp:n},i);return e.mergeEvaluated(s,r.Name),i}t.if(r._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=i(l);let r=!0;for(let t=0;t<d.length;t++){let l=d[t];if((null==l?void 0:l.$ref)&&!(0,a.schemaHasRulesButRef)(l,u.self.RULES)){const e=l.$ref;if(l=s.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),l instanceof s.SchemaEnv&&(l=l.schema),void 0===l)throw new o.default(u.opts.uriResolver,u.baseId,e)}const p=null===(e=null==l?void 0:l.properties)||void 0===e?void 0:e[h];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${h}"`);r=r&&(n||i(l)),c(p,t)}if(!r)throw new Error(`discriminator: "${h}" must be required`);return t;function i({required:e}){return Array.isArray(e)&&e.includes(h)}function c(e,t){if(e.const)p(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${h}" must have "const" or "enum"`);for(const n of e.enum)p(n,t)}}function p(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${h}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(r._`${m} === ${e}`),t.assign(p,f(n[e]));t.else(),e.error(!1,{discrError:i.DiscrError.Mapping,tag:m,tagName:h}),t.endIf()}()),(()=>e.error(!1,{discrError:i.DiscrError.Tag,tag:m,tagName:h}))),e.ok(p)}};t.default=c},7652:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2128),i=n(7060),s=n(6378),o=n(5520),a=n(5413),c=n(3265),l=n(7532),u=n(9857),d=[o.default,r.default,i.default,(0,s.default)(!0),l.default,u.metadataVocabulary,u.contentVocabulary,a.default,c.default];t.default=d},6144:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2128),i=n(7060),s=n(6378),o=n(7532),a=n(9857),c=[r.default,i.default,(0,s.default)(),o.default,a.metadataVocabulary,a.contentVocabulary];t.default=c},2476:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const r=n(9029),i=n(2023),s=n(3835),o=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>c(e,e.schema)};function c(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const c=r._`${i.default.dynamicAnchors}${(0,r.getProperty)(t)}`,l="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:r}=e.it,{root:i,baseId:a,localRefs:c,meta:l}=t.root,{schemaId:u}=r.opts,d=new s.SchemaEnv({schema:n,schemaId:u,root:i,baseId:a,localRefs:c,meta:l});return s.compileSchema.call(r,d),(0,o.getValidate)(e,d)}(e);n.if(r._`!${c}`,(()=>n.assign(c,l)))}t.dynamicAnchor=c,t.default=a},3252:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const r=n(9029),i=n(2023),s=n(3693),o={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:o,it:a}=e;if("#"!==t[0])throw new Error(`"${o}" only supports hash fragment reference`);const c=t.slice(1);if(a.allErrors)l();else{const t=n.let("valid",!1);l(t),e.ok(t)}function l(e){if(a.schemaEnv.root.dynamicAnchors[c]){const t=n.let("_v",r._`${i.default.dynamicAnchors}${(0,r.getProperty)(c)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,r){return r?()=>n.block((()=>{(0,s.callRef)(e,t),n.let(r,!0)})):()=>(0,s.callRef)(e,t)}}t.dynamicRef=a,t.default=o},5520:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2476),i=n(3252),s=n(2721),o=n(3799),a=[r.default,i.default,s.default,o.default];t.default=a},2721:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2476),i=n(4227),s={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,r.dynamicAnchor)(e,""):(0,i.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=s},3799:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3252),i={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,r.dynamicRef)(e,e.schema)};t.default=i},4737:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match format "${e}"`,params:({schemaCode:e})=>r._`{format: ${e}}`},code(e,t){const{gen:n,data:i,$data:s,schema:o,schemaCode:a,it:c}=e,{opts:l,errSchemaPath:u,schemaEnv:d,self:h}=c;l.validateFormats&&(s?function(){const s=n.scopeValue("formats",{ref:h.formats,code:l.code.formats}),o=n.const("fDef",r._`${s}[${a}]`),c=n.let("fType"),u=n.let("format");n.if(r._`typeof ${o} == "object" && !(${o} instanceof RegExp)`,(()=>n.assign(c,r._`${o}.type || "string"`).assign(u,r._`${o}.validate`)),(()=>n.assign(c,r._`"string"`).assign(u,o))),e.fail$data((0,r.or)(!1===l.strictSchema?r.nil:r._`${a} && !${u}`,function(){const e=d.$async?r._`(${o}.async ? await ${u}(${i}) : ${u}(${i}))`:r._`${u}(${i})`,n=r._`(typeof ${u} == "function" ? ${e} : ${u}.test(${i}))`;return r._`${u} && ${u} !== true && ${c} === ${t} && !${n}`}()))}():function(){const s=h.formats[o];if(!s)return void function(){if(!1!==l.strictSchema)throw new Error(e());function e(){return`unknown format "${o}" ignored in schema at path "${u}"`}h.logger.warn(e())}();if(!0===s)return;const[a,c,p]=function(e){const t=e instanceof RegExp?(0,r.regexpCode)(e):l.code.formats?r._`${l.code.formats}${(0,r.getProperty)(o)}`:void 0,i=n.scopeValue("formats",{key:o,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,i]:[e.type||"string",e.validate,r._`${i}.validate`]}(s);a===t&&e.pass(function(){if("object"==typeof s&&!(s instanceof RegExp)&&s.async){if(!d.$async)throw new Error("async format in sync schema");return r._`await ${p}(${i})`}return"function"==typeof c?r._`${p}(${i})`:r._`${p}.test(${i})`}())}())}};t.default=i},7532:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=[n(4737).default];t.default=r},9857:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(1846),i=n(4845),s=n(2626),o=[r.default,i.default,s.default];t.default=o},3265:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(392),i=n(3445),s=[r.default,i.default];t.default=s},3445:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:s,it:o}=e,a=o.items||0;if(!0===a)return;const c=t.const("len",r._`${s}.length`);if(!1===n)e.setParams({len:a}),e.fail(r._`${c} > ${a}`);else if("object"==typeof n&&!(0,i.alwaysValidSchema)(o,n)){const n=t.var("valid",r._`${c} <= ${a}`);t.if((0,r.not)(n),(()=>function(n,s){t.forRange("i",s,c,(s=>{e.subschema({keyword:"unevaluatedItems",dataProp:s,dataPropType:i.Type.Num},n),o.allErrors||t.if((0,r.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}o.items=!0}};t.default=s},392:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(2023),o={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>r._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:o,errsCount:a,it:c}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:l,props:u}=c;function d(s){if(!1===n)return e.setParams({unevaluatedProperty:s}),e.error(),void(l||t.break());if(!(0,i.alwaysValidSchema)(c,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:s,dataPropType:i.Type.Str},n),l||t.if((0,r.not)(n),(()=>t.break()))}}u instanceof r.Name?t.if(r._`${u} !== true`,(()=>t.forIn("key",o,(e=>t.if(function(e,t){return r._`!${e} || !${e}[${t}]`}(u,e),(()=>d(e))))))):!0!==u&&t.forIn("key",o,(e=>void 0===u?d(e):t.if(function(e,t){const n=[];for(const i in e)!0===e[i]&&n.push(r._`${t} !== ${i}`);return(0,r.and)(...n)}(u,e),(()=>d(e))))),c.props=!0,e.ok(r._`${a} === ${s.default.errors}`)}};t.default=o},7935:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(6250),o={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>r._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:o,schemaCode:a,schema:c}=e;o||c&&"object"==typeof c?e.fail$data(r._`!${(0,i.useFunc)(t,s.default)}(${n}, ${a})`):e.fail(r._`${c} !== ${n}`)}};t.default=o},1846:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3025),i={keyword:"dependentRequired",type:"object",schemaType:"object",error:r.error,code:e=>(0,r.validatePropertyDeps)(e)};t.default=i},8643:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(6250),o={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>r._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:o,schema:a,schemaCode:c,it:l}=e;if(!o&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=l.opts.loopEnum;let d;const h=()=>null!=d?d:d=(0,i.useFunc)(t,s.default);let p;if(u||o)p=t.let("valid"),e.block$data(p,(function(){t.assign(p,!1),t.forOf("v",c,(e=>t.if(r._`${h()}(${n}, ${e})`,(()=>t.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",c);p=(0,r.or)(...a.map(((t,i)=>function(e,t){const i=a[t];return"object"==typeof i&&null!==i?r._`${h()}(${n}, ${e}[${t}])`:r._`${n} === ${i}`}(e,i))))}e.pass(p)}};t.default=o},7060:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5882),i=n(3439),s=n(7307),o=n(422),a=n(4486),c=n(4003),l=n(1163),u=n(617),d=n(7935),h=n(8643),p=[r.default,i.default,s.default,o.default,a.default,c.default,l.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},d.default,h.default];t.default=p},2626:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,r.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=i},1163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:i}=e,s="maxItems"===t?r.operators.GT:r.operators.LT;e.fail$data(r._`${n}.length ${s} ${i}`)}};t.default=i},7307:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(3853),o={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o,it:a}=e,c="maxLength"===t?r.operators.GT:r.operators.LT,l=!1===a.opts.unicode?r._`${n}.length`:r._`${(0,i.useFunc)(e.gen,s.default)}(${n})`;e.fail$data(r._`${l} ${c} ${o}`)}};t.default=o},5882:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=r.operators,s={maximum:{okStr:"<=",ok:i.LTE,fail:i.GT},minimum:{okStr:">=",ok:i.GTE,fail:i.LT},exclusiveMaximum:{okStr:"<",ok:i.LT,fail:i.GTE},exclusiveMinimum:{okStr:">",ok:i.GT,fail:i.LTE}},o={message:({keyword:e,schemaCode:t})=>r.str`must be ${s[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>r._`{comparison: ${s[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(s),type:"number",schemaType:"number",$data:!0,error:o,code(e){const{keyword:t,data:n,schemaCode:i}=e;e.fail$data(r._`${n} ${s[t].fail} ${i} || isNaN(${n})`)}};t.default=a},4486:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:i}=e,s="maxProperties"===t?r.operators.GT:r.operators.LT;e.fail$data(r._`Object.keys(${n}).length ${s} ${i}`)}};t.default=i},3439:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>r.str`must be multiple of ${e}`,params:({schemaCode:e})=>r._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:i,it:s}=e,o=s.opts.multipleOfPrecision,a=t.let("res"),c=o?r._`Math.abs(Math.round(${a}) - ${a}) > 1e-${o}`:r._`${a} !== parseInt(${a})`;e.fail$data(r._`(${i} === 0 || (${a} = ${n}/${i}, ${c}))`)}};t.default=i},422:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match pattern "${e}"`,params:({schemaCode:e})=>i._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:s,schemaCode:o,it:a}=e,c=a.opts.unicodeRegExp?"u":"",l=n?i._`(new RegExp(${o}, ${c}))`:(0,r.usePattern)(e,s);e.fail$data(i._`!${l}.test(${t})`)}};t.default=s},4003:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(4227),o={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>i.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>i._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:o,data:a,$data:c,it:l}=e,{opts:u}=l;if(!c&&0===n.length)return;const d=n.length>=u.loopRequired;if(l.allErrors?function(){if(d||c)e.block$data(i.nil,h);else for(const t of n)(0,r.checkReportMissingProp)(e,t)}():function(){const s=t.let("missing");if(d||c){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,s){e.setParams({missingProperty:n}),t.forOf(n,o,(()=>{t.assign(s,(0,r.propertyInData)(t,a,n,u.ownProperties)),t.if((0,i.not)(s),(()=>{e.error(),t.break()}))}),i.nil)}(s,n))),e.ok(n)}else t.if((0,r.checkMissingProp)(e,n,s)),(0,r.reportMissingProp)(e,s),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:r}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!r.has(e)){const t=`required property "${e}" is not defined at "${l.schemaEnv.baseId+l.errSchemaPath}" (strictRequired)`;(0,s.checkStrictMode)(l,t,l.opts.strictRequired)}}function h(){t.forOf("prop",o,(n=>{e.setParams({missingProperty:n}),t.if((0,r.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=o},617:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(208),i=n(9029),s=n(4227),o=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>i.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>i._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:c,parentSchema:l,schemaCode:u,it:d}=e;if(!a&&!c)return;const h=t.let("valid"),p=l.items?(0,r.getSchemaTypes)(l.items):[];function m(s,o){const a=t.name("item"),c=(0,r.checkDataTypes)(p,a,d.opts.strictNumbers,r.DataType.Wrong),l=t.const("indices",i._`{}`);t.for(i._`;${s}--;`,(()=>{t.let(a,i._`${n}[${s}]`),t.if(c,i._`continue`),p.length>1&&t.if(i._`typeof ${a} == "string"`,i._`${a} += "_"`),t.if(i._`typeof ${l}[${a}] == "number"`,(()=>{t.assign(o,i._`${l}[${a}]`),e.error(),t.assign(h,!1).break()})).code(i._`${l}[${a}] = ${s}`)}))}function f(r,a){const c=(0,s.useFunc)(t,o.default),l=t.name("outer");t.label(l).for(i._`;${r}--;`,(()=>t.for(i._`${a} = ${r}; ${a}--;`,(()=>t.if(i._`${c}(${n}[${r}], ${n}[${a}])`,(()=>{e.error(),t.assign(h,!1).break(l)}))))))}e.block$data(h,(function(){const r=t.let("i",i._`${n}.length`),s=t.let("j");e.setParams({i:r,j:s}),t.assign(h,!0),t.if(i._`${r} > 1`,(()=>(p.length>0&&!p.some((e=>"object"===e||"array"===e))?m:f)(r,s)))}),i._`${u} === false`),e.ok(h)}};t.default=a},5488:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=o},5999:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},857:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}"],sourceRoot:""}]);const a=o},6369:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},7939:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=o},3017:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=o},6314:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",r=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),r&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),r&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,r,i,s){"string"==typeof e&&(e=[[null,e,void 0]]);var o={};if(r)for(var a=0;a<this.length;a++){var c=this[a][0];null!=c&&(o[c]=!0)}for(var l=0;l<e.length;l++){var u=[].concat(e[l]);r&&o[u[0]]||(void 0!==s&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=s),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),i&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=i):u[4]="".concat(i)),t.push(u))}},t}},1354:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var r=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),i="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(r),s="/*# ".concat(i," */");return[t].concat([s]).join("\n")}return[t].join("\n")}},2017:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var r,i,s;if(Array.isArray(t)){if((r=t.length)!=n.length)return!1;for(i=r;0!=i--;)if(!e(t[i],n[i]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((r=(s=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(i=r;0!=i--;)if(!Object.prototype.hasOwnProperty.call(n,s[i]))return!1;for(i=r;0!=i--;){var o=s[i];if(!e(t[o],n[o]))return!1}return!0}return t!=t&&n!=n}},9982:function(e,t,n){var r;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,r,i,s){for(var o,a,c,l,u,d,h,p,m,f,g,y,w;s>=64;){for(o=n[0],a=n[1],c=n[2],l=n[3],u=n[4],d=n[5],h=n[6],p=n[7],f=0;f<16;f++)g=i+4*f,e[f]=(255&r[g])<<24|(255&r[g+1])<<16|(255&r[g+2])<<8|255&r[g+3];for(f=16;f<64;f++)y=((m=e[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,w=((m=e[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,e[f]=(y+e[f-7]|0)+(w+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&d^~u&h)|0)+(p+(t[f]+e[f]|0)|0)|0,w=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&c^a&c)|0,p=h,h=d,d=u,u=l+y|0,l=c,c=a,a=o,o=y+w|0;n[0]+=o,n[1]+=a,n[2]+=c,n[3]+=l,n[4]+=u,n[5]+=d,n[6]+=h,n[7]+=p,i+=64,s-=64}return i}var r=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var r=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[r++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(r=n(this.temp,this.state,e,r,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[r++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,r=this.bufferLength,i=t/536870912|0,s=t<<3,o=t%64<56?64:128;this.buffer[r]=128;for(var a=r+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=i>>>24&255,this.buffer[o-7]=i>>>16&255,this.buffer[o-6]=i>>>8&255,this.buffer[o-5]=i>>>0&255,this.buffer[o-4]=s>>>24&255,this.buffer[o-3]=s>>>16&255,this.buffer[o-2]=s>>>8&255,this.buffer[o-1]=s>>>0&255,n(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=r;var i=function(){function e(e){this.inner=new r,this.outer=new r,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new r).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function s(e){var t=(new r).update(e),n=t.digest();return t.clean(),n}function o(e,t){var n=new i(e).update(t),r=n.digest();return n.clean(),r}function a(e,t,n,r){var i=r[0];if(0===i)throw new Error("hkdf: cannot expand more");t.reset(),i>1&&t.update(e),n&&t.update(n),t.update(r),t.finish(e),r[0]++}e.HMAC=i,e.hash=s,e.default=s,e.hmac=o;var c=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,r){void 0===t&&(t=c),void 0===r&&(r=32);for(var s=new Uint8Array([1]),l=o(t,e),u=new i(l),d=new Uint8Array(u.digestLength),h=d.length,p=new Uint8Array(r),m=0;m<r;m++)h===d.length&&(a(d,u,n,s),h=0),p[m]=d[h++];return u.clean(),d.fill(0),s.fill(0),p},e.pbkdf2=function(e,t,n,r){for(var s=new i(e),o=s.digestLength,a=new Uint8Array(4),c=new Uint8Array(o),l=new Uint8Array(o),u=new Uint8Array(r),d=0;d*o<r;d++){var h=d+1;a[0]=h>>>24&255,a[1]=h>>>16&255,a[2]=h>>>8&255,a[3]=h>>>0&255,s.reset(),s.update(t),s.update(a),s.finish(l);for(var p=0;p<o;p++)c[p]=l[p];for(p=2;p<=n;p++){s.reset(),s.update(l).finish(l);for(var m=0;m<o;m++)c[m]^=l[m]}for(p=0;p<o&&d*o+p<r;p++)u[d*o+p]=c[p]}for(d=0;d<o;d++)c[d]=l[d]=0;for(d=0;d<4;d++)a[d]=0;return s.clean(),u}}(t);var i=t.default;for(var s in t)i[s]=t[s];"object"==typeof e.exports?e.exports=i:void 0===(r=function(){return i}.call(t,n,t,e))||(e.exports=r)}()},2787:(e,t,n)=>{"use strict";n.d(t,{I:()=>i});const r=new Uint32Array(65536),i=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,i=t.length,s=1<<n-1;let o=-1,a=0,c=n,l=n;for(;l--;)r[e.charCodeAt(l)]|=1<<l;for(l=0;l<i;l++){let e=r[t.charCodeAt(l)];const n=e|a;e|=(e&o)+o^o,a|=~(e|o),o&=e,a&s&&c++,o&s&&c--,a=a<<1|1,o=o<<1|~(n|a),a&=n}for(l=n;l--;)r[e.charCodeAt(l)]=0;return c})(e,t):((e,t)=>{const n=t.length,i=e.length,s=[],o=[],a=Math.ceil(n/32),c=Math.ceil(i/32);for(let e=0;e<a;e++)o[e]=-1,s[e]=0;let l=0;for(;l<c-1;l++){let a=0,c=-1;const u=32*l,d=Math.min(32,i)+u;for(let t=u;t<d;t++)r[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=r[t.charCodeAt(e)],i=o[e/32|0]>>>e&1,l=s[e/32|0]>>>e&1,u=n|a,d=((n|l)&c)+c^c|n|l;let h=a|~(d|c),p=c&d;h>>>31^i&&(o[e/32|0]^=1<<e),p>>>31^l&&(s[e/32|0]^=1<<e),h=h<<1|i,p=p<<1|l,c=p|~(u|h),a=h&u}for(let t=u;t<d;t++)r[e.charCodeAt(t)]=0}let u=0,d=-1;const h=32*l,p=Math.min(32,i-h)+h;for(let t=h;t<p;t++)r[e.charCodeAt(t)]|=1<<t;let m=i;for(let e=0;e<n;e++){const n=r[t.charCodeAt(e)],a=o[e/32|0]>>>e&1,c=s[e/32|0]>>>e&1,l=n|u,h=((n|c)&d)+d^d|n|c;let p=u|~(h|d),f=d&h;m+=p>>>i-1&1,m-=f>>>i-1&1,p>>>31^a&&(o[e/32|0]^=1<<e),f>>>31^c&&(s[e/32|0]^=1<<e),p=p<<1|a,f=f<<1|c,d=f|~(l|p),u=p&l}for(let t=h;t<p;t++)r[e.charCodeAt(t)]=0;return m})(e,t)}},9937:e=>{e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(e,t)=>{t.assign=function(e){e=e||{};var t,n,r,i=Array.prototype.slice.call(arguments).slice(1);for(t=0,r=i.length;t<r;t++)if(i[t])for(n in i[t])e[n]=i[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,r=e.order,i=e.size,s={},o=new Float32Array(10*r),a=new Float32Array(3*i);return n=0,e.forEachNode((function(e,t){s[e]=n,o[n]=t.x,o[n+1]=t.y,o[n+2]=0,o[n+3]=0,o[n+4]=0,o[n+5]=0,o[n+6]=1,o[n+7]=1,o[n+8]=t.size||1,o[n+9]=t.fixed?1:0,n+=10})),n=0,e.forEachEdge((function(e,r,i,c,l,u,d){var h=s[i],p=s[c],m=t(e,r,i,c,l,u,d);o[h+6]+=m,o[p+6]+=m,a[n]=h,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:o,edges:a}},t.assignLayoutChanges=function(e,t,n){var r=0;e.updateEachNodeAttributes((function(e,i){return i.x=t[r],i.y=t[r+1],r+=10,n?n(e,i):i}))},t.readGraphPositions=function(e,t){var n=0;e.forEachNode((function(e,r){t[n]=r.x,t[n+1]=r.y,n+=10}))},t.collectLayoutChanges=function(e,t,n){for(var r=e.nodes(),i={},s=0,o=0,a=t.length;s<a;s+=10){if(n){var c=Object.assign({},e.getNodeAttributes(r[o]));c.x=t[s],c.y=t[s+1],c=n(r[o],c),i[r[o]]={x:c.x,y:c.y}}else i[r[o]]={x:t[s],y:t[s+1]};o++}return i},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),r=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),i=new Worker(r);return t.revokeObjectURL(r),i}},8903:(e,t,n)=>{var r=n(1736),i=n(8153).Fd,s=n(2561),o=n(1782),a=n(9937);function c(e,t,n){if(!r(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var c=n.iterations;if("number"!=typeof c)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(c<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var l=i("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,d=o.assign({},a,n.settings),h=o.validateSettings(d);if(h)throw new Error("graphology-layout-forceatlas2: "+h.message);var p,m=o.graphToByteArrays(t,l);for(p=0;p<c;p++)s(d,m.nodes,m.edges);if(!e)return o.collectLayoutChanges(t,m.nodes);o.assignLayoutChanges(t,m.nodes,u)}var l=c.bind(null,!1);l.assign=c.bind(null,!0),l.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=l},2561:e=>{var t=10;e.exports=function(e,n,r){var i,s,o,a,c,l,u,d,h,p,m,f,g,y,w,b,v,A,E,C,T,S,_,x=n.length,P=r.length,M=e.adjustSizes,$=e.barnesHutTheta*e.barnesHutTheta,N=[];for(o=0;o<x;o+=t)n[o+4]=n[o+2],n[o+5]=n[o+3],n[o+2]=0,n[o+3]=0;if(e.outboundAttractionDistribution){for(m=0,o=0;o<x;o+=t)m+=n[o+6];m/=x/t}if(e.barnesHutOptimize){var L,I,R,O=1/0,k=-1/0,G=1/0,H=-1/0;for(o=0;o<x;o+=t)O=Math.min(O,n[o+0]),k=Math.max(k,n[o+0]),G=Math.min(G,n[o+1]),H=Math.max(H,n[o+1]);var D=k-O,F=H-G;for(D>F?H=(G-=(D-F)/2)+D:k=(O-=(F-D)/2)+F,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+H)/2,N[3]=Math.max(k-O,H-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,i=1,o=0;o<x;o+=t)for(s=0,R=3;;){if(!(N[s+5]>=0)){if(N[s+0]<0){N[s+0]=o;break}if(N[s+5]=9*i,d=N[s+3]/2,N[(h=N[s+5])+0]=-1,N[h+1]=N[s+1]-d,N[h+2]=N[s+2]-d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]-d,N[h+2]=N[s+2]+d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]+d,N[h+2]=N[s+2]-d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]+d,N[h+2]=N[s+2]+d,N[h+3]=d,N[h+4]=N[s+4],N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,i+=4,L=n[N[s+0]+0]<N[s+1]?n[N[s+0]+1]<N[s+2]?N[s+5]:N[s+5]+9:n[N[s+0]+1]<N[s+2]?N[s+5]+18:N[s+5]+27,N[s+6]=n[N[s+0]+6],N[s+7]=n[N[s+0]+0],N[s+8]=n[N[s+0]+1],N[L+0]=N[s+0],N[s+0]=-1,L===(I=n[o+0]<N[s+1]?n[o+1]<N[s+2]?N[s+5]:N[s+5]+9:n[o+1]<N[s+2]?N[s+5]+18:N[s+5]+27)){if(R--){s=L;continue}R=3;break}N[I+0]=o;break}L=n[o+0]<N[s+1]?n[o+1]<N[s+2]?N[s+5]:N[s+5]+9:n[o+1]<N[s+2]?N[s+5]+18:N[s+5]+27,N[s+7]=(N[s+7]*N[s+6]+n[o+0]*n[o+6])/(N[s+6]+n[o+6]),N[s+8]=(N[s+8]*N[s+6]+n[o+1]*n[o+6])/(N[s+6]+n[o+6]),N[s+6]+=n[o+6],s=L}}if(e.barnesHutOptimize){for(f=e.scalingRatio,o=0;o<x;o+=t)for(s=0;;)if(N[s+5]>=0){if(b=Math.pow(n[o+0]-N[s+7],2)+Math.pow(n[o+1]-N[s+8],2),4*(p=N[s+3])*p/b<$){if(g=n[o+0]-N[s+7],y=n[o+1]-N[s+8],!0===M?b>0?(v=f*n[o+6]*N[s+6]/b,n[o+2]+=g*v,n[o+3]+=y*v):b<0&&(v=-f*n[o+6]*N[s+6]/Math.sqrt(b),n[o+2]+=g*v,n[o+3]+=y*v):b>0&&(v=f*n[o+6]*N[s+6]/b,n[o+2]+=g*v,n[o+3]+=y*v),(s=N[s+4])<0)break;continue}s=N[s+5]}else if((l=N[s+0])>=0&&l!==o&&(b=(g=n[o+0]-n[l+0])*g+(y=n[o+1]-n[l+1])*y,!0===M?b>0?(v=f*n[o+6]*n[l+6]/b,n[o+2]+=g*v,n[o+3]+=y*v):b<0&&(v=-f*n[o+6]*n[l+6]/Math.sqrt(b),n[o+2]+=g*v,n[o+3]+=y*v):b>0&&(v=f*n[o+6]*n[l+6]/b,n[o+2]+=g*v,n[o+3]+=y*v)),(s=N[s+4])<0)break}else for(f=e.scalingRatio,a=0;a<x;a+=t)for(c=0;c<a;c+=t)g=n[a+0]-n[c+0],y=n[a+1]-n[c+1],!0===M?(b=Math.sqrt(g*g+y*y)-n[a+8]-n[c+8])>0?(v=f*n[a+6]*n[c+6]/b/b,n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v):b<0&&(v=100*f*n[a+6]*n[c+6],n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v):(b=Math.sqrt(g*g+y*y))>0&&(v=f*n[a+6]*n[c+6]/b/b,n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v);for(h=e.gravity/e.scalingRatio,f=e.scalingRatio,o=0;o<x;o+=t)v=0,g=n[o+0],y=n[o+1],b=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.strongGravityMode?b>0&&(v=f*n[o+6]*h):b>0&&(v=f*n[o+6]*h/b),n[o+2]-=g*v,n[o+3]-=y*v;for(f=1*(e.outboundAttractionDistribution?m:1),u=0;u<P;u+=3)a=r[u+0],c=r[u+1],d=r[u+2],w=Math.pow(d,e.edgeWeightInfluence),g=n[a+0]-n[c+0],y=n[a+1]-n[c+1],!0===M?(b=Math.sqrt(g*g+y*y)-n[a+8]-n[c+8],e.linLogMode?e.outboundAttractionDistribution?b>0&&(v=-f*w*Math.log(1+b)/b/n[a+6]):b>0&&(v=-f*w*Math.log(1+b)/b):e.outboundAttractionDistribution?b>0&&(v=-f*w/n[a+6]):b>0&&(v=-f*w)):(b=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?b>0&&(v=-f*w*Math.log(1+b)/b/n[a+6]):b>0&&(v=-f*w*Math.log(1+b)/b):e.outboundAttractionDistribution?(b=1,v=-f*w/n[a+6]):(b=1,v=-f*w)),b>0&&(n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v);if(!0===M)for(o=0;o<x;o+=t)1!==n[o+9]&&((A=Math.sqrt(Math.pow(n[o+2],2)+Math.pow(n[o+3],2)))>10&&(n[o+2]=10*n[o+2]/A,n[o+3]=10*n[o+3]/A),E=n[o+6]*Math.sqrt((n[o+4]-n[o+2])*(n[o+4]-n[o+2])+(n[o+5]-n[o+3])*(n[o+5]-n[o+3])),C=Math.sqrt((n[o+4]+n[o+2])*(n[o+4]+n[o+2])+(n[o+5]+n[o+3])*(n[o+5]+n[o+3]))/2,T=.1*Math.log(1+C)/(1+Math.sqrt(E)),S=n[o+0]+n[o+2]*(T/e.slowDown),n[o+0]=S,_=n[o+1]+n[o+3]*(T/e.slowDown),n[o+1]=_);else for(o=0;o<x;o+=t)1!==n[o+9]&&(E=n[o+6]*Math.sqrt((n[o+4]-n[o+2])*(n[o+4]-n[o+2])+(n[o+5]-n[o+3])*(n[o+5]-n[o+3])),C=Math.sqrt((n[o+4]+n[o+2])*(n[o+4]+n[o+2])+(n[o+5]+n[o+3])*(n[o+5]+n[o+3]))/2,T=n[o+7]*Math.log(1+C)/(1+Math.sqrt(E)),n[o+7]=Math.min(1,Math.sqrt(T*(Math.pow(n[o+2],2)+Math.pow(n[o+3],2))/(1+Math.sqrt(E)))),S=n[o+0]+n[o+2]*(T/e.slowDown),n[o+0]=S,_=n[o+1]+n[o+3]*(T/e.slowDown),n[o+1]=_);return{}}},8153:(e,t)=>{function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},r=function(e){return void 0===e?t:e};"function"==typeof t&&(r=t);var i=function(t){return r(t[e])},s=function(){return r(void 0)};return"string"==typeof e?(n.fromAttributes=i,n.fromGraph=function(e,t){return i(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return i(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var i=t.extremities(n);return r(e(n,t.getEdgeAttributes(n),i[0],i[1],t.getNodeAttributes(i[0]),t.getNodeAttributes(i[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,i,s,o,a,c){return r(e(t,n,i,s,o,a,c))},n.fromPartialEntry=function(t,n,i,s){return r(e(t,n,i,s))},n.fromMinimalEntry=function(t,n){return r(e(t,n))}):(n.fromAttributes=s,n.fromGraph=s,n.fromEntry=s,n.fromMinimalEntry=s),n}(e,n)}},1736:e=>{e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934:function(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,r(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function r(e,t){return r=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},r(e,t)}function i(e,t,n){return i=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var i=[null];i.push.apply(i,t);var s=new(Function.bind.apply(e,i));return n&&r(s,n.prototype),s},i.apply(null,arguments)}function s(e){var t="function"==typeof Map?new Map:void 0;return s=function(e){if(null===e||(s=e,-1===Function.toString.call(s).indexOf("[native code]")))return e;var s;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,o)}function o(){return i(e,arguments,n(this).constructor)}return o.prototype=Object.create(e.prototype,{constructor:{value:o,enumerable:!1,writable:!0,configurable:!0}}),r(o,e)},s(e)}function o(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var r in arguments[t])e[r]=arguments[t][r];return e};function c(e,t,n,r){var i=e._nodes.get(t),s=null;return i?s="mixed"===r?i.out&&i.out[n]||i.undirected&&i.undirected[n]:"directed"===r?i.out&&i.out[n]:i.undirected&&i.undirected[n]:s}function l(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function d(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function h(e,t,n){var r={enumerable:!0,configurable:!0};"function"==typeof n?r.get=n:(r.value=n,r.writable=!1),Object.defineProperty(e,t,r)}function p(e){return!(!l(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var w=Number.isNaN||function(e){return e!=e};function b(){b.init.call(this)}f.exports=b,f.exports.once=function(e,t){return new Promise((function(n,r){function i(n){e.removeListener(t,s),r(n)}function s(){"function"==typeof e.removeListener&&e.removeListener("error",i),n([].slice.call(arguments))}M(e,t,s,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&M(e,"error",t,{once:!0})}(e,i)}))},b.EventEmitter=b,b.prototype._events=void 0,b.prototype._eventsCount=0,b.prototype._maxListeners=void 0;var v=10;function A(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function E(e){return void 0===e._maxListeners?b.defaultMaxListeners:e._maxListeners}function C(e,t,n,r){var i,s,o,a;if(A(n),void 0===(s=e._events)?(s=e._events=Object.create(null),e._eventsCount=0):(void 0!==s.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),s=e._events),o=s[t]),void 0===o)o=s[t]=n,++e._eventsCount;else if("function"==typeof o?o=s[t]=r?[n,o]:[o,n]:r?o.unshift(n):o.push(n),(i=E(e))>0&&o.length>i&&!o.warned){o.warned=!0;var c=new Error("Possible EventEmitter memory leak detected. "+o.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");c.name="MaxListenersExceededWarning",c.emitter=e,c.type=t,c.count=o.length,a=c,console&&console.warn&&console.warn(a)}return e}function T(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function S(e,t,n){var r={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},i=T.bind(r);return i.listener=n,r.wrapFn=i,i}function _(e,t,n){var r=e._events;if(void 0===r)return[];var i=r[t];return void 0===i?[]:"function"==typeof i?n?[i.listener||i]:[i]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(i):P(i,i.length)}function x(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function P(e,t){for(var n=new Array(t),r=0;r<t;++r)n[r]=e[r];return n}function M(e,t,n,r){if("function"==typeof e.on)r.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,(function i(s){r.once&&e.removeEventListener(t,i),n(s)}))}}function $(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(b,"defaultMaxListeners",{enumerable:!0,get:function(){return v},set:function(e){if("number"!=typeof e||e<0||w(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");v=e}}),b.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},b.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||w(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},b.prototype.getMaxListeners=function(){return E(this)},b.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var r="error"===e,i=this._events;if(void 0!==i)r=r&&void 0===i.error;else if(!r)return!1;if(r){var s;if(t.length>0&&(s=t[0]),s instanceof Error)throw s;var o=new Error("Unhandled error."+(s?" ("+s.message+")":""));throw o.context=s,o}var a=i[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var c=a.length,l=P(a,c);for(n=0;n<c;++n)y(l[n],this,t)}return!0},b.prototype.addListener=function(e,t){return C(this,e,t,!1)},b.prototype.on=b.prototype.addListener,b.prototype.prependListener=function(e,t){return C(this,e,t,!0)},b.prototype.once=function(e,t){return A(t),this.on(e,S(this,e,t)),this},b.prototype.prependOnceListener=function(e,t){return A(t),this.prependListener(e,S(this,e,t)),this},b.prototype.removeListener=function(e,t){var n,r,i,s,o;if(A(t),void 0===(r=this._events))return this;if(void 0===(n=r[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete r[e],r.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(i=-1,s=n.length-1;s>=0;s--)if(n[s]===t||n[s].listener===t){o=n[s].listener,i=s;break}if(i<0)return this;0===i?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,i),1===n.length&&(r[e]=n[0]),void 0!==r.removeListener&&this.emit("removeListener",e,o||t)}return this},b.prototype.off=b.prototype.removeListener,b.prototype.removeAllListeners=function(e){var t,n,r;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var i,s=Object.keys(n);for(r=0;r<s.length;++r)"removeListener"!==(i=s[r])&&this.removeAllListeners(i);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(r=t.length-1;r>=0;r--)this.removeListener(e,t[r]);return this},b.prototype.listeners=function(e){return _(this,e,!0)},b.prototype.rawListeners=function(e){return _(this,e,!1)},b.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):x.call(e,t)},b.prototype.listenerCount=x,b.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&($.prototype[Symbol.iterator]=function(){return this}),$.of=function(){var e=arguments,t=e.length,n=0;return new $((function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}}))},$.empty=function(){return new $((function(){return{done:!0}}))},$.fromSequence=function(e){var t=0,n=e.length;return new $((function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}}))},$.is=function(e){return e instanceof $||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=$,L={};L.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,L.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var I=N,R=L,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?I.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},H=G,D=function(e,t){for(var n,r=arguments.length>1?t:1/0,i=r!==1/0?new Array(r):[],s=0,o=H(e);;){if(s===r)return i;if((n=o.next()).done)return s!==t&&(i.length=s),i;i[s++]=n.value}},F=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(s(Error)),U=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F),V=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F),Y=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F);function B(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function j(e,t){this.key=e,this.attributes=t,this.clear()}function K(e,t,n,r,i){this.key=t,this.attributes=i,this.undirected=e,this.source=n,this.target=r}function q(e,t,n,r,i,s,o){var a,c,l,u;if(r=""+r,0===n){if(!(a=e._nodes.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" node in the graph.'));l=i,u=s}else if(3===n){if(i=""+i,!(c=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));var d=c.source.key,h=c.target.key;if(r===d)a=c.target;else{if(r!==h)throw new V("Graph.".concat(t,': the "').concat(r,'" node is not attached to the "').concat(i,'" edge (').concat(d,", ").concat(h,")."));a=c.source}l=s,u=o}else{if(!(c=e._edges.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" edge in the graph.'));a=1===n?c.source:c.target,l=i,u=s}return[a,l,u]}B.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},j.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},K.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,r=this.target.key;this.source[e][r]=this,this.undirected&&n===r||(this.target[t][n]=this)},K.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,r=this.target.key;this.undirected&&(e=t="undirected");var i=this.source[e],s=i[r];if(void 0===s)return i[r]=this,void(this.undirected&&n===r||(this.target[t][n]=this));s.previous=this,this.next=s,i[r]=this,this.target[t][n]=this},K.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",r="in";this.undirected&&(n=r="undirected"),delete this.source[n][t],delete this.target[r][e]},K.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",r="in";this.undirected&&(n=r="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[r][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[r][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return o.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){return q(this,t,n,e,r)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return o.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i,s){var o=q(this,t,n,e,r,i,s),a=o[0],c=o[1],l=o[2];return a.attributes[c]=l,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:c}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i,s){var o=q(this,t,n,e,r,i,s),a=o[0],c=o[1],l=o[2];if("function"!=typeof l)throw new U("Graph.".concat(t,": updater should be a function."));var u=a.attributes,d=l(u[c]);return u[c]=d,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:c}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return delete o.attributes[a],this.emit("nodeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];if(!l(a))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=a,this.emit("nodeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],c=s[1];if(!l(c))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,c),this.emit("nodeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:c}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];if("function"!=typeof a)throw new U("Graph.".concat(t,": provided updater is not a function."));return o.attributes=a(o.attributes),this.emit("nodeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes[r]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var i=""+e,s=""+arguments[1];if(!(r=c(this,i,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(i,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes.hasOwnProperty(r)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,a=""+r;if(r=arguments[2],i=arguments[3],!(s=c(this,o,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(s=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return s.attributes[r]=i,this.emit("edgeAttributesUpdated",{key:s.key,type:"set",attributes:s.attributes,name:r}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,a=""+r;if(r=arguments[2],i=arguments[3],!(s=c(this,o,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(s=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new U("Graph.".concat(t,": updater should be a function."));return s.attributes[r]=i(s.attributes[r]),this.emit("edgeAttributesUpdated",{key:s.key,type:"set",attributes:s.attributes,name:r}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete i.attributes[r],this.emit("edgeAttributesUpdated",{key:i.key,type:"remove",attributes:i.attributes,name:r}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!l(r))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return i.attributes=r,this.emit("edgeAttributesUpdated",{key:i.key,type:"replace",attributes:i.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!l(r))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return a(i.attributes,r),this.emit("edgeAttributesUpdated",{key:i.key,type:"merge",attributes:i.attributes,data:r}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof r)throw new U("Graph.".concat(t,": provided updater is not a function."));return i.attributes=r(i.attributes),this.emit("edgeAttributesUpdated",{key:i.key,type:"update",attributes:i.attributes}),this}}}],X=N,J=G,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var r=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(r=t.next()).done)break;t=null}return r}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,r){var i=!1;for(var s in t)if(s!==r){var o=t[s];if(i=n(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&i)return o.key}}function ne(e,t,n,r){var i,s,o,a=!1;for(var c in t)if(c!==r){i=t[c];do{if(s=i.source,o=i.target,a=n(i.key,i.attributes,s.key,o.key,s.attributes,o.attributes,i.undirected),e&&a)return i.key;i=i.next}while(void 0!==i)}}function re(e,t){var n,r=Object.keys(e),i=r.length,s=0;return new N((function(){do{if(n)n=n.next;else{if(s>=i)return{done:!0};var o=r[s++];if(o===t){n=void 0;continue}n=e[o]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function ie(e,t,n,r){var i=t[n];if(i){var s=i.source,o=i.target;return r(i.key,i.attributes,s.key,o.key,s.attributes,o.attributes,i.undirected)&&e?i.key:void 0}}function se(e,t,n,r){var i=t[n];if(i){var s=!1;do{if(s=r(i.key,i.attributes,i.source.key,i.target.key,i.source.attributes,i.target.attributes,i.undirected),e&&s)return i.key;i=i.next}while(void 0!==i)}}function oe(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,r){if(0!==t.size)for(var i,s,o="mixed"!==n&&n!==t.type,a="undirected"===n,c=!1,l=t._edges.values();!0!==(i=l.next()).done;)if(s=i.value,!o||s.undirected===a){var u=s,d=u.key,h=u.attributes,p=u.source,m=u.target;if(c=r(d,h,p.key,m.key,p.attributes,m.attributes,s.undirected),e&&c)return d}}function ce(e,t,n,r,i,s){var o,a=t?ne:te;if("undirected"!==n){if("out"!==r&&(o=a(e,i.in,s),e&&o))return o;if("in"!==r&&(o=a(e,i.out,s,r?void 0:i.key),e&&o))return o}if("directed"!==n&&(o=a(e,i.undirected,s),e&&o))return o}function le(e,t,n,r,i,s,o){var a,c=n?se:ie;if("undirected"!==t){if(void 0!==i.in&&"out"!==r&&(a=c(e,i.in,s,o),e&&a))return a;if(void 0!==i.out&&"in"!==r&&(r||i.key!==s)&&(a=c(e,i.out,s,o),e&&a))return a}if("directed"!==t&&void 0!==i.undirected&&(a=c(e,i.undirected,s,o),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function de(){this.A=null,this.B=null}function he(e,t,n,r,i){for(var s in r){var o=r[s],a=o.source,c=o.target,l=a===n?c:a;if(!t||!t.has(l.key)){var u=i(l.key,l.attributes);if(e&&u)return l.key}}}function pe(e,t,n,r,i){if("mixed"!==t){if("undirected"===t)return he(e,null,r,r.undirected,i);if("string"==typeof n)return he(e,null,r,r[n],i)}var s,o=new de;if("undirected"!==t){if("out"!==n){if(s=he(e,null,r,r.in,i),e&&s)return s;o.wrap(r.in)}if("in"!==n){if(s=he(e,o,r,r.out,i),e&&s)return s;o.wrap(r.out)}}if("directed"!==t&&(s=he(e,o,r,r.undirected,i),e&&s))return s}function me(e,t,n){var r=Object.keys(n),i=r.length,s=0;return new N((function(){var o=null;do{if(s>=i)return e&&e.wrap(n),{done:!0};var a=n[r[s++]],c=a.source,l=a.target;o=c===t?l:c,e&&e.has(o.key)&&(o=null)}while(null===o);return{done:!1,value:{neighbor:o.key,attributes:o.attributes}}}))}function fe(e,t,n,r,i){for(var s,o,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(s=h.next()).done;){var m=!1;if(o=s.value,"undirected"!==p)for(a in c=o.out){l=c[a];do{if(u=l.target,m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=o.undirected)if(!(t&&o.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=i(o.key,null,o.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new U('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new U("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!l(e))throw new U('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new U("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new U("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new U("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var we,be=(we=255&Math.floor(256*Math.random()),function(){return we++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ee={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ce(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Te(e,t,n,r,i,s,o,a){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,o=""+o,a=a||{},!e.allowSelfLoops&&s===o)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(s),u=e._nodes.get(o);if(!c)throw new V("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(o,'" not found.'));var d={key:null,undirected:r,source:s,target:o,attributes:a};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new Y("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[o]:void 0!==c.out[o]))throw new Y("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(o,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,i,c,u,a);e._edges.set(i,h);var p=s===o;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=i,e.emit("edgeAdded",d),i}function Se(e,t,n,r,i,s,o,c,u){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new U("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(s=""+s,o=""+o,u&&(d=c,c=void 0),!e.allowSelfLoops&&s===o)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(s),f=e._nodes.get(o);if(!n&&(h=e._edges.get(i))){if(!(h.source.key===s&&h.target.key===o||r&&h.source.key===o&&h.target.key===s))throw new Y("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(i,'" edge with "').concat(s,'" source & "').concat(o,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[o]:m.out[o]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var w={key:null,undirected:r,source:s,target:o,attributes:c};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new Y("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));var b=!1,v=!1;m||(m=Ce(e,s,{}),b=!0,s===o&&(f=m,v=!0)),f||(f=Ce(e,o,{}),v=!0),h=new K(r,i,m,f,c),e._edges.set(i,h);var A=s===o;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,w.key=i,e.emit("edgeAdded",w),[i,!0,b,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,i=t.attributes,s=t.undirected,o=n===r;s?(n.undirectedDegree--,r.undirectedDegree--,o&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,o&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:i,source:n.key,target:r.key,undirected:s})}var xe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ee,e)).multi)throw new U("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new U('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new U("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?B:"directed"===e.type?W:j;d(o(t),"NodeDataClass",r);var i="geid_"+be()+"_",s=0;return d(o(t),"_attributes",{}),d(o(t),"_nodes",new Map),d(o(t),"_edges",new Map),d(o(t),"_directedSize",0),d(o(t),"_undirectedSize",0),d(o(t),"_directedSelfLoopCount",0),d(o(t),"_undirectedSelfLoopCount",0),d(o(t),"_edgeKeyGenerator",(function(){var e;do{e=i+s++}while(t._edges.has(e));return e})),d(o(t),"_options",e),Ae.forEach((function(e){return d(o(t),e,t[e])})),h(o(t),"order",(function(){return t._nodes.size})),h(o(t),"size",(function(){return t._edges.size})),h(o(t),"directedSize",(function(){return t._directedSize})),h(o(t),"undirectedSize",(function(){return t._undirectedSize})),h(o(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(o(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(o(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(o(t),"multi",t._options.multi),h(o(t),"type",t._options.type),h(o(t),"allowSelfLoops",t._options.allowSelfLoops),h(o(t),"implementation",(function(){return"graphology"})),t}t(r,n);var i=r.prototype;return i._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},i.hasNode=function(e){return this._nodes.has(""+e)},i.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.out.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.undirected.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new U("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},i.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},i.edge=function(e,t){if(this.multi)throw new Y("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},i.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},i.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},i.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},i.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},i.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},i.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},i.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},i.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},i.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},i.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},i.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},i.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},i.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},i.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},i.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},i.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},i.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},i.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},i.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},i.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},i.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},i.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},i.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},i.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},i.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,i=n.target.key;if(e===r)return i;if(e===i)return r;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(i,")."))},i.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},i.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},i.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},i.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},i.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new U('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new Y('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},i.mergeNode=function(e,t){if(t&&!l(t))throw new U('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},i.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new U('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var i=t?t({}):{};return n=new this.NodeDataClass(e,i),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:i}),[e,!0]},i.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var i in n.in){t=n.in[i];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},i.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},i.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},i.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},i.getAttribute=function(e){return this._attributes[e]},i.getAttributes=function(){return this._attributes},i.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},i.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.updateAttribute=function(e,t){if("function"!=typeof t)throw new U("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},i.replaceAttributes=function(e){if(!l(e))throw new U("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},i.mergeAttributes=function(e){if(!l(e))throw new U("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},i.updateAttributes=function(e){if("function"!=typeof e)throw new U("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},i.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i=this._nodes.values();!0!==(n=i.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},i.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i,s,o=this._edges.values();!0!==(n=o.next()).done;)i=(r=n.value).source,s=r.target,r.attributes=e(r.key,r.attributes,i.key,s.key,i.attributes,s.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},i.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},i.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},i.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},i.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},i.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):D(this._nodes.keys(),this._nodes.size)},i.forEachNode=function(e){if("function"!=typeof e)throw new U("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},i.findNode=function(e){if("function"!=typeof e)throw new U("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},i.mapNodes=function(e){if("function"!=typeof e)throw new U("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),i=new Array(this.order),s=0;!0!==(t=r.next()).done;)n=t.value,i[s++]=e(n.key,n.attributes);return i},i.someNode=function(e){if("function"!=typeof e)throw new U("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},i.everyNode=function(e){if("function"!=typeof e)throw new U("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},i.filterNodes=function(e){if("function"!=typeof e)throw new U("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),i=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&i.push(n.key);return i},i.reduceNodes=function(e,t){if("function"!=typeof e)throw new U("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new U("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,i=t,s=this._nodes.values();!0!==(n=s.next()).done;)i=e(i,(r=n.value).key,r.attributes);return i},i.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},i.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,i){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,i,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},i.import=function(e){var t,n,i,s,o,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,i,s,o){c?o?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):o?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new U("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new U("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(i=e.nodes,!Array.isArray(i))throw new U("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=i.length;t<n;t++){ge(s=i[t]);var u=s,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),i=e.edges,!Array.isArray(i))throw new U("Graph.import: invalid edges. Expecting an array.");for(t=0,n=i.length;t<n;t++){ye(o=i[t]);var m=o,f=m.source,g=m.target,y=m.attributes,w=m.undirected,b=void 0===w?p:w;"key"in o?(c?b?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:b?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,o.key,f,g,y):(c?b?this.mergeUndirectedEdge:this.mergeDirectedEdge:b?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},i.nullCopy=function(e){var t=new r(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},i.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var r=a({},e.attributes);e=new t.NodeDataClass(n,r),t._nodes.set(n,e)})),t},i.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new Y('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new Y("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new Y("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,r=this.emptyCopy(e),i=this._edges.values();!0!==(t=i.next()).done;)Te(r,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return r},i.toJSON=function(){return this.export()},i.toString=function(){return"[object Graph]"},i.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var r={},i={};this._edges.forEach((function(e,n){var s,o=e.undirected?"--":"->",a="",c=e.source.key,l=e.target.key;e.undirected&&c>l&&(s=c,c=l,l=s);var u="(".concat(c,")").concat(o,"(").concat(l,")");n.startsWith("geid_")?t.multi&&(void 0===i[u]?i[u]=0:i[u]++,a+="".concat(i[u],". ")):a+="[".concat(n,"]: "),r[a+=u]=e.attributes}));var s={};for(var o in this)this.hasOwnProperty(o)&&!Ae.has(o)&&"function"!=typeof this[o]&&"symbol"!==e(o)&&(s[o]=this[o]);return s.attributes=this._attributes,s.nodes=n,s.edges=r,d(s,"constructor",this.constructor),s},r}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(xe.prototype[Symbol.for("nodejs.util.inspect.custom")]=xe.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(e){["add","merge","update"].forEach((function(t){var n=e.name(t),r="add"===t?Te:Se;e.generateKey?xe.prototype[n]=function(i,s,o){return r(this,n,!0,"undirected"===(e.type||this.type),null,i,s,o,"update"===t)}:xe.prototype[n]=function(i,s,o,a){return r(this,n,!1,"undirected"===(e.type||this.type),i,s,o,a,"update"===t)}}))})),function(e){z.forEach((function(t){var n=t.name,r=t.attacher;r(e,n("Node"),0),r(e,n("Source"),1),r(e,n("Target"),2),r(e,n("Opposite"),3)}))}(xe),function(e){Z.forEach((function(t){var n=t.name,r=t.attacher;r(e,n("Edge"),"mixed"),r(e,n("DirectedEdge"),"directed"),r(e,n("UndirectedEdge"),"undirected")}))}(xe),function(e){ee.forEach((function(t){!function(e,t){var n=t.name,r=t.type,i=t.direction;e.prototype[n]=function(e,t){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):D(e._edges.keys(),e._edges.size);for(var n,r,i="undirected"===t?e.undirectedSize:e.directedSize,s=new Array(i),o="undirected"===t,a=e._edges.values(),c=0;!0!==(n=a.next()).done;)(r=n.value).undirected===o&&(s[c++]=r.key);return s}(this,r);if(1===arguments.length){e=""+e;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,r){var i=[];return ce(!1,e,t,n,r,(function(e){i.push(e)})),i}(this.multi,"mixed"===r?this.type:r,i,s)}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);if(!o)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,r,i){var s=[];return le(!1,e,t,n,r,i,(function(e){s.push(e)})),s}(r,this.multi,i,o,t)}throw new U("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t,n){if("mixed"===r||"mixed"===this.type||r===this.type){if(1===arguments.length)return ae(!1,this,r,n=e);if(2===arguments.length){e=""+e,n=t;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return ce(!1,this.multi,"mixed"===r?this.type:r,i,o,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return le(!1,r,this.multi,i,a,t,n)}throw new U("Graph.".concat(s,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var o="map"+n[0].toUpperCase()+n.slice(1);e.prototype[o]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var i=0;"directed"!==r&&(i+=this.undirectedSize),"undirected"!==r&&(i+=this.directedSize),e=new Array(i);var o=0;t.push((function(t,r,i,s,a,c,l){e[o++]=n(t,r,i,s,a,c,l)}))}else e=[],t.push((function(t,r,i,s,o,a,c){e.push(n(t,r,i,s,o,a,c))}));return this[s].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push((function(e,r,i,s,o,a,c){t(e,r,i,s,o,a,c)&&n.push(e)})),this[s].apply(this,e),n};var c="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[c]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new U("Graph.".concat(c,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new U("Graph.".concat(c,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var r=t;return n.push((function(t,n,i,s,o,a,c){r=e(r,t,n,i,s,o,a,c)})),this[s].apply(this,n),r}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t,n){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return!1;if(1===arguments.length)return ae(!0,this,r,n=e);if(2===arguments.length){e=""+e,n=t;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return ce(!0,this.multi,"mixed"===r?this.type:r,i,o,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return le(!0,r,this.multi,i,a,t,n)}throw new U("Graph.".concat(s,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var o="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,r,i,s,o,a){return t(e,n,r,i,s,o,a)})),!!this[s].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,r,i,s,o,a){return!t(e,n,r,i,s,o,a)})),!this[s].apply(this,e)}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n.slice(0,-1)+"Entries";e.prototype[s]=function(e,t){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,r="undirected"===t,i=e._edges.values();return new N((function(){for(var e,t;;){if((e=i.next()).done)return e;if(t=e.value,!n||t.undirected===r)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}}))}(this,r);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var r=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(r=Q(r,re(n.in))),"in"!==t&&void 0!==n.out&&(r=Q(r,re(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(r=Q(r,re(n.undirected))),r}(r,i,n)}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);if(!o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,r){var i=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&r in n.in&&(i=Q(i,oe(n.in,r))),void 0!==n.out&&"in"!==t&&r in n.out&&(t||n.key!==r)&&(i=Q(i,oe(n.out,r)))),"directed"!==e&&void 0!==n.undirected&&r in n.undirected&&(i=Q(i,oe(n.undirected,r))),i}(r,i,o,t)}throw new U("Graph.".concat(s,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)}))}(xe),function(e){ue.forEach((function(t){(function(e,t){var n=t.name,r=t.type,i=t.direction;e.prototype[n]=function(e){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var r=[];return pe(!1,e,t,n,(function(e){r.push(e)})),r}("mixed"===r?this.type:r,i,t)}})(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t){if("mixed"===r||"mixed"===this.type||r===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));pe(!1,"mixed"===r?this.type:r,i,n,t)}};var o="map"+n[0].toUpperCase()+n.slice(1);e.prototype[o]=function(e,t){var n=[];return this[s](e,(function(e,r){n.push(t(e,r))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[s](e,(function(e,r){t(e,r)&&n.push(e)})),n};var c="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[c]=function(e,t,n){if(arguments.length<3)throw new U("Graph.".concat(c,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var r=n;return this[s](e,(function(e,n){r=t(r,e,n)})),r}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n[0].toUpperCase()+n.slice(1,-1),o="find"+s;e.prototype[o]=function(e,t){if("mixed"===r||"mixed"===this.type||r===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return pe(!0,"mixed"===r?this.type:r,i,n,t)}};var a="some"+s;e.prototype[a]=function(e,t){return!!this[o](e,t)};var c="every"+s;e.prototype[c]=function(e,t){return!this[o](e,(function(e,n){return!t(e,n)}))}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n.slice(0,-1)+"Entries";e.prototype[s]=function(e){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return me(null,n,n.undirected);if("string"==typeof t)return me(null,n,n[t])}var r=N.empty(),i=new de;return"undirected"!==e&&("out"!==t&&(r=Q(r,me(i,n,n.in))),"in"!==t&&(r=Q(r,me(i,n,n.out)))),"directed"!==e&&(r=Q(r,me(i,n,n.undirected))),r}("mixed"===r?this.type:r,i,t)}}(e,t)}))}(xe);var Pe=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new U("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new U('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(xe),Me=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new U("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new U('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(xe),$e=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(xe),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new U('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(xe),Le=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new U('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(xe);function Ie(e){e.from=function(t,n){var r=a({},t.options,n),i=new e(r);return i.import(t),i}}return Ie(xe),Ie(Pe),Ie(Me),Ie($e),Ie(Ne),Ie(Le),xe.Graph=xe,xe.DirectedGraph=Pe,xe.UndirectedGraph=Me,xe.MultiGraph=$e,xe.MultiDirectedGraph=Ne,xe.MultiUndirectedGraph=Le,xe.InvalidArgumentsGraphError=U,xe.NotFoundGraphError=V,xe.UsageGraphError=Y,xe}()},944:(e,t)=>{"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var r=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var r=0,i=e.length,s=t.length,o=Math.floor(Math.max(i,s)/2)-1,a=new Array(i),c=new Array(s),l=0;l<i;l++)for(var u=Math.max(0,l-o);u<=Math.min(s,l+o+1);u++)if(!a[l]&&!c[u]&&e[l]===t[u]){++r,a[l]=c[u]=!0;break}if(0===r)return 0;var d=0,h=0;for(l=0;l<i;l++)if(a[l]){for(;!c[h];)h++;e.charAt(l)!==t.charAt(h++)&&d++}return(r/i+r/s+(r-(d/=2))/r)/3}(e,t,n),i=0;if(r>.7){for(var s=Math.min(e.length,t.length),o=0;e[o]===t[o]&&o<4&&o<s;)++i,o++;r+=.1*i*(1-r)}return r}},7106:e=>{"use strict";var t=e.exports=function(e,t,r){"function"==typeof t&&(r=t,t={}),n(t,"function"==typeof(r=t.cb||r)?r:r.pre||function(){},r.post||function(){},e,"",e)};function n(e,r,i,s,o,a,c,l,u,d){if(s&&"object"==typeof s&&!Array.isArray(s)){for(var h in r(s,o,a,c,l,u,d),s){var p=s[h];if(Array.isArray(p)){if(h in t.arrayKeywords)for(var m=0;m<p.length;m++)n(e,r,i,p[m],o+"/"+h+"/"+m,a,o,h,s,m)}else if(h in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,r,i,p[f],o+"/"+h+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,o,h,s,f)}else(h in t.keywords||e.allKeys&&!(h in t.skipKeywords))&&n(e,r,i,p,o+"/"+h,a,o,h,s)}i(s,o,a,c,l,u,d)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:e=>{"use strict";var t=[];function n(e){for(var n=-1,r=0;r<t.length;r++)if(t[r].identifier===e){n=r;break}return n}function r(e,r){for(var s={},o=[],a=0;a<e.length;a++){var c=e[a],l=r.base?c[0]+r.base:c[0],u=s[l]||0,d="".concat(l," ").concat(u);s[l]=u+1;var h=n(d),p={css:c[1],media:c[2],sourceMap:c[3],supports:c[4],layer:c[5]};if(-1!==h)t[h].references++,t[h].updater(p);else{var m=i(p,r);r.byIndex=a,t.splice(a,0,{identifier:d,updater:m,references:1})}o.push(d)}return o}function i(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,i){var s=r(e=e||[],i=i||{});return function(e){e=e||[];for(var o=0;o<s.length;o++){var a=n(s[o]);t[a].references--}for(var c=r(e,i),l=0;l<s.length;l++){var u=n(s[l]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}s=c}}},7659:e=>{"use strict";var t={};e.exports=function(e,n){var r=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!r)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");r.appendChild(n)}},540:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var r="";n.supports&&(r+="@supports (".concat(n.supports,") {")),n.media&&(r+="@media ".concat(n.media," {"));var i=void 0!==n.layer;i&&(r+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),r+=n.css,i&&(r+="}"),n.media&&(r+="}"),n.supports&&(r+="}");var s=n.sourceMap;s&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(s))))," */")),t.styleTagTransform(r,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},1407:(e,t,n)=>{"use strict";n.d(t,{R:()=>l});var r=n(4328),i=n(6082),s=n(567),o=n(826),a=n(2738);const c=31;async function l(e,t=!1,n){const a=o.GO.forColumn(e);let l;n??=new Map;const d=a.isHelm()?(0,s.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<d.length;e++)n.has(d[e])||n.set(d[e],`${n.size+1}`);if(a.isHelm())l=await r.functions.call("HELM:getMolFiles",{col:e}),l=function(e,t,n=!1){const r=new Array(e.length);for(let i=0;i<e.length;i++){let s=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(i);s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1;const u=parseInt(l.substring(s,s+3)),d=parseInt(l.substring(s+3,s+6));a+=`M V30 COUNTS ${u} ${d} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){s=l.indexOf("\n",s)+1+c,o=l.indexOf(" ",s);const r=l.substring(s,o);a+=n?`M V30 ${e+1} R${t.get(r)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(r)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<d;e++){s=l.indexOf("\n",s)+1;const t=parseInt(l.substring(s,s+3).trim()),n=parseInt(l.substring(s+3,s+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(s+6,s+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",r[i]=a}return r}(l,n,t);else{l=new Array(e.length);for(let r=0;r<e.length;r++){const e=u(a.getSplitted(r),n,t);l[r]=e}}return i.Column.fromStrings("monomericMols",l)}function u(e,t,n=!1){let r="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";r+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,r+="M V30 BEGIN ATOM\n";for(let i=0;i<e.length;i++){const s=e.getCanonical(i);s!==a._S&&(r+=n?`M V30 ${i+1} R${t.get(s)} 0.000 0.000 0 0\n`:`M V30 ${i+1} At 0.000 0.000 0 0 MASS=${t.get(s)}\n`)}r+="M V30 END ATOM\n",r+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)r+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return r+="M V30 END BOND\n",r+="M V30 END CTAB\n",r+="M END",r}},567:(e,t,n)=>{"use strict";n.d(t,{_package:()=>Ct,activityCliffs:()=>xt,getHelmMonomers:()=>Nt,getMonomerLib:()=>_t,getMonomerLibHelper:()=>Tt,importFasta:()=>$t,sequenceIdentityScoring:()=>Lt,sequenceSimilarityScoring:()=>It,sequenceSpaceTopMenu:()=>Pt,toAtomicLevel:()=>Mt});var r,i,s=n(4328),o=n(7389),a=n(6082),c=n(684),l=n(9039);(i=r||(r={})).EUCLIDEAN="EUCLIDEAN",i.MANHATTAN="MANHATTAN";var u=n(1858),d=n(5072),h=n.n(d),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),w=n.n(y),b=n(540),v=n.n(b),A=n(1113),E=n.n(A),C=n(7939),T={};T.styleTagTransform=E(),T.setAttributes=w(),T.insert=g().bind(null,"head"),T.domAPI=m(),T.insertStyleElement=v(),h()(C.A,T),C.A&&C.A.locals&&C.A.locals;var S=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};let _=null,x=null;Promise.resolve(),n(934),n(8903);const P="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;const M=rxjs.operators;n(6295);const $=e=>null==e;function N(e,t,n,r){if(n>e[e.length-1])return;const i=e.findIndex((e=>n<e));e.pop(),e.splice(i,0,n),t.pop(),t.splice(i,0,r)}class L{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,i,s=[{}],o=[1],a=r.EUCLIDEAN){const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,s,o,a):0;i<u&&(console.log(`using threshold ${u}`),i=u),s.forEach(((e,t)=>s[t].threshold=i));const d=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)d[n]=new Promise(((r,u)=>{const d=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=d&&r({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),h[n].postMessage({values:e,startIdx:d,endIdx:p,threshold:i,fnNames:t,opts:s,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,i:t,j:i,distance:s}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),r({i:t,j:i,distance:s,idx:n}))}}));const p=await Promise.all(d),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let w=0;for(const e of p)f.set(e.i,w),g.set(e.j,w),y.set(e.distance,w),w+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,r={}){return await this.calcMultiColumn([e],[t],n,[r],[1])}async getKNN(e,t,n=15,r={}){return await this.multiColumnKNN([e],[t],n,[r],[1])}async getThresholdKNN(e,t,n=.8,r={}){return await this.multiColumnThresholdKnn([e],[t],n,[r],[1])}async multiColumnThresholdKnn(e,t,i=.8,s,o,a=r.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((r,u)=>{const h=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=h&&r({knnDistances:new Array(0),knnIndexes:new Array(0)}),d[n].postMessage({values:e,startIdx:h,endIdx:p,fnNames:t,opts:s,threshold:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),r({knnDistances:t,knnIndexes:i}))}}));const h=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of h)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of h)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnKNN(e,t,i=15,s,o,a=r.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((r,u)=>{const h=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=h&&r({knnDistances:new Array(0),knnIndexes:new Array(0)}),d[n].postMessage({values:e,startIdx:h,endIdx:p,fnNames:t,opts:s,nNeighbours:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),r({knnDistances:t,knnIndexes:i}))}}));const h=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(-1)))};for(const t of h)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)N(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,i=[],s,o=r.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,r=Math.floor(n/this._workerCount),c=1e6,l=Math.max(Math.min(n/1e3,c),Math.min(n,c)),u=Math.floor(l/this._workerCount),d=new Array(this._workerCount);for(let c=0;c<this._workerCount;c++)d[c]=new Promise(((l,d)=>{const h=c*r,p=c===this._workerCount-1?n:(c+1)*r;a[c].postMessage({values:e,startIdx:h,endIdx:p,sampleLength:u,fnNames:t,opts:i,weights:s,aggregationMethod:o}),a[c].onmessage=({data:{error:e,distance:t}})=>{a[c].terminate(),e?d(e):l({distance:t})}}));const h=await Promise.all(d),p=h.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of h)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],i,s=r.EUCLIDEAN){try{const r=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,n,i,s);return 1-o[Math.floor(7e7/r*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,r){const i=[],s=[],o=[];let a=0,c=0,l=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=$(e[c])||$(e[l])?1:n(e[c],e[l]);1-t>=r&&(i.push(c),s.push(l),o.push(t)),a++,l++,l===e.length&&(c++,l=c+1)}return{i:new Int32Array(i),j:new Int32Array(s),distance:new Float32Array(o)}}}var I,R,O=n(8774);(R=I||(I={})).none="none",R.bold="bold",R.dashed="dashed";class k{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,r,i=I.none){var s;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=i,this.updateLines(r),this.visibility=null!==(s=r.visibility)&&void 0!==s?s:new O.A(this.lines.from.length),r.visibility||this.visibility.setAll(!0,!1),r.arrowSize&&(this.arrowWidth=r.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,r,i,s,o,a,c,l,u,d,h,p,m,f,g;const y=this.sp.getOptions().look,w=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;w||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=y.sizeColumnName?this.sp.dataFrame.col(y.sizeColumnName):null,v=this.sp.dataFrame.filter,A=Math.pow(null!==(r=this.lines.shortLineThreshold)&&void 0!==r?r:5,2);for(let e=0;e<this.lines.from.length;e++)if(v.get(this.lines.from[e])&&v.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:n,sizeTo:r}=this.getMarkersSizes(y,b,e),v=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let E=null==v?void 0:v.x,C=null==v?void 0:v.y;const T=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let S=null==T?void 0:T.x,_=null==T?void 0:T.y;const x=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),E&&C&&S&&_&&Math.hypot(S-E,_-C)/x>.01){if(w){const t=(null===(i=this.lines.colors)||void 0===i?void 0:i[e])?null===(s=this.lines.colors)||void 0===s?void 0:s[e]:null!==(o=this.lines.color)&&void 0!==o?o:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(c=this.lines.opacities)||void 0===c?void 0:c[e]:null!==(l=this.lines.opacity)&&void 0!==l?l:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(d=this.lines.widths)||void 0===d?void 0:d[e]:null!==(h=this.lines.width)&&void 0!==h?h:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const y=this.multipleLinesCounts[e];let b=null;if(y){t=this.getLineLength(E,C,S,_);const i=this.getPointOnDistance(E,C,S,_,r,t),s=this.getPointOnDistance(S,_,E,C,n,t);E=i.x,C=i.y,S=s.x,_=s.y,b=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(y,E,C,S,_,e):this.findControlPoint(y,S,_,E,C,e),this.ctx.moveTo(E,C),this.ctx.quadraticCurveTo(b.x,b.y,S,_)}else(!this.lines.skipShortLines||Math.pow(S-E,2)+Math.pow(_-C,2)>A)&&(this.ctx.moveTo(E,C),this.ctx.lineTo(S,_));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(E,C,S,_)),t>this.arrowWidth)){const e=y?null:this.getPointOnDistance(E,C,S,_,r,t),n=y?b.x:E,i=y?b.y:C;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:E,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:C,n,i)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case I.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case I.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,n){let r=3,i=3;return t?(r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[n]))/2,i=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[n]))/2):e.markerDefaultSize&&(r=e.markerDefaultSize/2,i=e.markerDefaultSize/2),{sizeFrom:r,sizeTo:i}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,r=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],r=this.lines.to[t]):(n=this.lines.to[t],r=this.lines.from[t]),e[`${n}|${r}`]?(1===e[`${n}|${r}`].length&&(this.multipleLinesCounts[e[`${n}|${r}`][0]]=1,e[`${n}|${r}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${r}`][1]):e[`${n}|${r}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,r=null,i=null;const s=this.sp.getOptions().look,o=s.sizeColumnName?this.sp.dataFrame.col(s.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let c=0;c<this.lines.from.length;c++)if(a.get(this.lines.from[c])&&a.get(this.lines.to[c])&&this.visibility.getBit(c)){const{sizeFrom:a,sizeTo:l}=this.getMarkersSizes(s,o,c),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[c]),this.yAxisCol.get(this.lines.from[c])),d=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[c]),this.yAxisCol.get(this.lines.to[c]));if(this.multipleLinesCounts[c]){const n=this.getLineLength(u.x,u.y,d.x,d.y),r=this.getPointOnDistance(u.x,u.y,d.x,d.y,l,n),s=this.getPointOnDistance(d.x,d.y,null==u?void 0:u.x,null==u?void 0:u.y,a,n),o=this.lines.from[c]>this.lines.to[c]?this.findControlPoint(this.multipleLinesCounts[c],r.x,r.y,s.x,s.y,c):this.findControlPoint(this.multipleLinesCounts[c],s.x,s.y,r.x,r.y,c);i=this.calculateDistToCurveLine(c,e,t,r,s,o)}else i=this.calculateDistToStraightLine(e,t,u,d);(!r&&null!==i&&i<5||r&&null!==i&&i<r)&&(r=i,n=c)}return n}calculateDistToStraightLine(e,t,n,r){const i=Math.min(n.x,r.x),s=Math.max(n.x,r.x),o=Math.min(n.y,r.y),a=Math.max(n.y,r.y);return e>=i-2&&e<=s+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,r):null}distToStraightLineSegment(e,t,n,r){const i=(e,t,n,r)=>Math.pow(e-n,2)+Math.pow(t-r,2),s=i(n.x,n.y,r.x,r.y);if(0==s)return i(e,t,n.x,n.y);let o=((e-n.x)*(r.x-n.x)+(t-n.y)*(r.y-n.y))/s;return o=Math.max(0,Math.min(1,o)),i(e,t,n.x+o*(r.x-n.x),n.y+o*(r.y-n.y))}calculateDistToCurveLine(e,t,n,r,i,s){const o=Math.min(r.x,i.x,s.x),a=Math.max(r.x,i.x,s.x),c=Math.min(r.y,i.y,s.y),l=Math.max(r.y,i.y,s.y);if(t>=o-2&&t<=a+2&&n>=c-2&&n<=l+2){const e=a-o,u=l-c;return this.calculateDistToCurveInRect(t,n,r,s,i,e,u)}return null}calculateDistToCurveInRect(e,t,n,r,i,s,o){const a=Math.floor((s+o)/3),c=1/a,l=new Uint32Array(a),u=new Uint32Array(a),d=new Uint32Array(a);let h=null;const p=new O.A(a);for(let s=0;s<l.length;s++){const o=s*c,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*r.x+Math.pow(o,2)*i.x,p=Math.pow(1-o,2)*n.y+2*o*(1-o)*r.y+Math.pow(o,2)*i.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!h||h>g)&&(h=g),d[s]=Math.max(m,f),l[s]=a,u[s]=p}for(let e=0;e<l.length;e++)d[e]<h&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const r=Math.hypot(l[n]-e,u[n]-t);(!m||m>r)&&(m=r)}return m}getLineLength(e,t,n,r){return Math.sqrt(Math.pow(n-e,2)+Math.pow(r-t,2))}getPointOnDistance(e,t,n,r,i,s){const o=n-i*((n-e)/s),c=r-i*((r-t)/s);return new a.Point(o,c)}findControlPoint(e,t,n,r,i,s){const o=t+(r-t)/2,c=n+(i-n)/2;let l=o-t,u=c-n;const d=Math.sqrt(l*l+u*u);l/=d,u/=d;const h=50*Math.ceil(e/2);return e%2==0?new a.Point(o+h/2*u,c-h/2*l):new a.Point(o-h/2*u,c+h/2*l)}canvasArrow(e,t,n,r,i){const s=Math.atan2(r-t,i-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(s-Math.PI/10),n-this.arrowWidth*Math.cos(s-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(s+Math.PI/10),n-this.arrowWidth*Math.cos(s+Math.PI/10))}}const G="dimensionality-reducer-terminate-event";var H,D,F=n(3629);async function U(e,t,r,i,o,a,c){let l=await async function(e,t,r,i,o,a,c){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==i.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(l,u){const d=new Worker(new URL(n.p+n.u(234),n.b));d.postMessage({columnsData:e,distanceMetrics:t,method:r,options:a,weights:i,aggregationMethod:o});const h=s.events.onCustomEvent(G).subscribe((()=>{try{d?.terminate()}finally{h.unsubscribe()}}));d.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:r}})=>{$(n)||$(r)?(h.unsubscribe(),e?u(e):l(t),setTimeout((()=>d.terminate()),100)):c&&c(n,r,t)}}))}(e,r,t,i,o,a,c);return l=l.map((e=>(0,F.S8)(e))),l}(D=H||(H={})).EUCLIDEAN="EUCLIDEAN",D.MANHATTAN="MANHATTAN";const V={[H.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[H.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Y,B;(B=Y||(Y={})).HAMMING="Hamming",B.EUCLIDEAN="Euclidean",B.MANHATTAN="Manhattan",B.TANIMOTO="Tanimoto",B.LEVENSTEIN="Levenshtein",B.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",B.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",B.SOKAL="Sokal",B.COSINE="Cosine",B.ASYMMETRIC="Asymmetric",B.Difference="Difference",B.OneHot="One-Hot";const W={[Y.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Y.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[Y.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[Y.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Y.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Y.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Y.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Y.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Y.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Y.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Y.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Y.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},j={[Y.HAMMING]:e=>Math.ceil(e/30),[Y.EUCLIDEAN]:e=>Math.ceil(e/30),[Y.MANHATTAN]:e=>Math.ceil(e/30),[Y.TANIMOTO]:e=>Math.ceil(e/60),[Y.SOKAL]:e=>Math.ceil(e/60),[Y.COSINE]:e=>Math.ceil(e/60),[Y.ASYMMETRIC]:e=>Math.ceil(e/60),[Y.LEVENSTEIN]:e=>Math.ceil(e*e/60),[Y.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[Y.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[Y.Difference]:e=>1,[Y.OneHot]:e=>Math.ceil(e/40)},K={STRING:new Set([Y.HAMMING,Y.LEVENSTEIN,Y.NEEDLEMAN_WUNSCH,Y.MONOMER_CHEMICAL_DISTANCE,Y.OneHot]),UINT32ARRAY:new Set([Y.HAMMING,Y.EUCLIDEAN,Y.MANHATTAN,Y.MONOMER_CHEMICAL_DISTANCE,Y.LEVENSTEIN,Y.NEEDLEMAN_WUNSCH,Y.TANIMOTO,Y.COSINE,Y.SOKAL,Y.ASYMMETRIC,Y.OneHot,Y.Difference]),INT32ARRAY:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.OneHot,Y.Difference]),FLOAT32ARRAY:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.Difference]),NUMBER:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.Difference]),BITARRAY:new Set([Y.TANIMOTO,Y.COSINE,Y.SOKAL,Y.ASYMMETRIC])};var q=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function z(e,t,n,r){return e.map(((e,r)=>`\n fn distanceScript${r}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${r}[aIndex];\n let b = computeInfo.data${r}[bIndex];\n let maxDistance: f32 = ${n};\n ${W[e](t[r],r)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${V[r](e.length)}\n }\n \n `}let Z=0;const X="cliffsDf",J=new u.Subject,Q="activity_difference",ee="SALI_index",te="similarity",ne="line_index",re=["1_molecule","2_molecule"],ie="filterCliffs";async function se(e,t,r,i,c,l,u,d,h,p,m,f,g,y,w,b,v){Z++;const A=l/100;let E,C=!1;const T=f.inputs,$=await f.apply({[T[0].name]:t,[T[1].name]:u,...h.preprocessingFuncArgs??{}});let N=[];if(d===P){const t=await function(e,t,r,i,s,o,a=10,c=!1,l=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let d;return u.postMessage({data:e,threshold:t,weights:r,aggregationMethod:i,distanceFns:s,distanceFnArgs:o,maxIterations:a,useWebGPU:c,inflate:l}),{promise:new Promise(((e,t)=>{d=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{d(null),u.terminate()}catch(e){console.error(e)}}}}([$.entries],l,[1],"MANHATTAN",[u],[$.options??{}],h?.maxIterations??5,h.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),N=[t.embedX,t.embedY]}else N=await U([$.entries],d,[u],[1],"MANHATTAN",{...h,distanceFnArgs:[$.options??{}]});if(N.length!==r.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<N.length;++t)e.columns.addNewFloat(r[t]).init((e=>N[t][e]));let R=null;if(h.useWebGPU)try{R=await function(e,t=.8,n,r,i,s){return q(this,void 0,void 0,(function*(){const o=yield function(){return S(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==_))return null;let e=!1;if(x&&(x.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!x||e){const e=1e9,t=_.limits,n=t.maxBufferSize,r=t.maxStorageBufferBindingSize;try{return x=yield _.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(r,e)}}),x}catch(e){return console.error("Failed to create device with required limits",e),x=yield _.requestDevice(),x}}return x}))}();if(!o)return null;const a=Object.values(Y);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(H).includes(r))throw new Error("Invalid aggregation function provided: "+r);const c=1-t;if(s.length!==e.length||s.length!==n.length||s.length!==i.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const l=e.length,u=e[0].length,d=e.map(((e,t)=>function(e,t=Y.HAMMING,n,r={gapOpenPenalty:1,gapExtensionPenalty:.6}){var i,s;let o=null;const a=e.some((e=>"string"==typeof e))?(o="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(o="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(o="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(o="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(o="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(o="INT32ARRAY",e):void 0;if(!a||!o)throw new Error("Invalid entry type, could not determine entry type from input list");const c=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",l=new Uint32Array(a.map((e=>e.length)));if(!K[o]||!K[o].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${o}'`);const u=l.reduce(((e,t)=>Math.max(e,t)),0),d=j[t](u),h="INT32ARRAY"===c?Int32Array:"FLOAT32ARRAY"===c?Float32Array:Uint32Array,p=new h(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(t===Y.NEEDLEMAN_WUNSCH||t===Y.MONOMER_CHEMICAL_DISTANCE){let e=r.scoringMatrix&&r.alphabetIndexes?Object.keys(r.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!r.alphabetIndexes||!r.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);r.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),r.alphabetIndexes={};for(let e=0;e<r.scoringMatrix.length;e++)r.scoringMatrix[e][e]=1,r.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),o=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)o[t][t]=1;const a=r.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(o[e.charCodeAt(0)][t.charCodeAt(0)]=r.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(i=r.gapOpenPenalty)&&void 0!==i?i:1,y[1]=null!==(s=r.gapExtensionPenalty)&&void 0!==s?s:.6;let c=2;for(let e=0;e<o.length;e++)y.set(o[e],c),c+=o[e].length;m=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===Y.Difference){if(!r.range||"number"!=typeof r.range||r.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);r.range=t-e}r.range<=0&&(r.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([r.range]),m=`\n range${n}: f32`}const w=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",b=`data${n}: array<array<${w}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:l,complexity:d,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:o,dataTypeWGSL:w,dataStructWgsl:b,EncodedArrayConstructor:h}}(e,n[t],t,s[t])));if(0===l)throw new Error("No columns provided. Please provide at least one column of data.");1===l&&(r=H.MANHATTAN);let h=d.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;h&&""!=h.trim()||(p=!0,h="\ndummy: f32\n");const m=d.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(l*u);d.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,w=d.reduce(((e,t)=>e+t.complexity),0),b=Math.ceil(6e3/w),v=Math.ceil(Math.sqrt(Math.ceil(100))),A=10*v,E=u*(u-1)/2,C=Math.ceil(E/g),T=o.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${C} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${l}>,\n // the weights for each entry\n weights: array<f32, ${l}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${h}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${A} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${b}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${c}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${z(n,d.map((e=>e.maxEntryLen)),c,r)}\n\n\n `}),P=o.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),M=new Uint32Array(g),$=new Uint32Array(g),N=new Uint32Array(g),L=new Uint32Array(g),I=Math.floor(E/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?E-1:(e+1)*I,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),r=t-u*n+Math.floor((n+1)*(n+2)/2);M[e]=O,$[e]=R,N[e]=r,L[e]=n,R=n,O=r}console.timeEnd("GPUthreadStarts");const k=4e4+u*l+l+d.reduce(((e,t)=>e+t.sourceArraySize),0),G=d.reduce(((e,t)=>e+t.suppInfoSize),0),D=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let U=F;const V=15&F;0!==V&&(U+=16-V);const B=o.createBuffer({label:"compute info buffer",size:U,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=B.getMappedRange();let q=0;new Uint32Array(W,q,g).set(M),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set($),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set(N),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set(L),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f.length).set(f),q+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,q,l).set(i),q+=l*Float32Array.BYTES_PER_ELEMENT;for(const e of d){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,q,n).set(e.flatSourceArray),q+=n*t.BYTES_PER_ELEMENT}B.unmap();const Z=G*Uint32Array.BYTES_PER_ELEMENT;let X=Z;const J=15&Z;0!==J&&(X+=16-J),X=Math.max(X,16);const Q=o.createBuffer({label:"supp info buffer",size:X,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of d)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let re=ne;const ie=15&ne;0!==ie&&(re+=16-ie);const se=o.createBuffer({label:"results buffer",size:re,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),oe=o.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:P.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:B}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:se}}]}),ae=o.createBuffer({label:"results out buffer",size:se.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),ce=[],le=[],ue=[];let de=!1;for(;!de;){const e=o.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(P),t.setBindGroup(0,oe),t.dispatchWorkgroups(v,v),t.end(),e.copyBufferToBuffer(se,0,ae,0,ae.size);const n=e.finish();o.queue.submit([n]),yield o.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const r=ae.getMappedRange();let i=0;const s=new Uint32Array(r,i,D);i+=D*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(r,i,D);i+=D*Uint32Array.BYTES_PER_ELEMENT;const c=new Float32Array(r,i,D);i+=D*Float32Array.BYTES_PER_ELEMENT;const l=new Uint32Array(r,i,g);i+=g*Uint32Array.BYTES_PER_ELEMENT,de=new Uint32Array(r,i,g).every((e=>1===e));const u=l.reduce(((e,t)=>e+t),0),d=new Uint32Array(u),h=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<l.length;e++){const t=l[e];0!==t&&(d.set(s.subarray(e*y,e*y+t),m),h.set(a.subarray(e*y,e*y+t),m),p.set(c.subarray(e*y,e*y+t),m),m+=t)}ce.push(d),le.push(h),ue.push(p),ae.unmap()}const he=ce.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(he),me=new Uint32Array(he),fe=new Float32Array(he);let ge=0;for(let e=0;e<ce.length;e++)pe.set(ce[e],ge),me.set(le[e],ge),fe.set(ue[e],ge),ge+=ce[e].length;return B.destroy(),Q.destroy(),se.destroy(),ae.destroy(),{i:pe,j:me,distance:fe}}))}([$.entries],A,[u],H.MANHATTAN,[1],[$.options??{}])}catch(e){console.error(e)}R||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),R=await(new L).calc($.entries,u,A,$.options));const O=await async function(e,t){const n=e.distance.map(((n,r)=>{const i=Math.abs(t.get(e.i[r])-t.get(e.j[r]));return 0!=n?i/n:1/0})),r=e.distance.map((e=>1-e)),i=e.i,s=e.j,o=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{o.set(e.i[n],!0),o.set(e.j[n],!0)})),{simVals:r,saliVals:n,n1:i,n2:s,cliffsBitSet:o}}(R,c),G=function(e,t,n,r,i,s,o){const c=new Array(e).fill(0);for(let e=0;e!=r.length;++e)n[e]!=1/0&&(o.get(r[e])>o.get(i[e])?c[r[e]]+=n[e]:c[i[e]]+=n[e]);return a.Column.fromList("double",t,c)}(t.length,`sali_${r[0].substring(r[0].lastIndexOf("_"))}`,O.saliVals,O.n1,O.n2,0,c);e.columns.add(G);const D=O.cliffsBitSet,F=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}(O.saliVals),V=.8/(F.max-F.min),B=v?s.shell.view("Browse").preview:s.shell.getTableView(e.name),W=B.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:r[0],yColumnName:r[1],size:G.name,color:c.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:i}),se=function(e,t,n,r,i,s,o,c){const l={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)l.from[n]=t.n1[n],l.to[n]=t.n2[n],l.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-o.min)*c,l.colors[n]=e.selection.get(l.from[n])&&e.selection.get(l.to[n])?"255,255,0":"0,128,0",l.widths[n]=1;const u=a.DataFrame.create(l.from.length);return re.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?l.from[e]:l.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),s),u.col(e).semType=i})),u.columns.addNewFloat(Q).init((e=>Math.abs(r.get(l.from[e])-r.get(l.to[e])))),u.columns.addNewInt(ne).init((e=>e)),u.columns.addNewFloat(ee).init((e=>t.saliVals[e])),u.columns.addNewFloat(te).init((e=>t.simVals[e])),u.name=`${X}${Z}`,{lines:l,linesDf:u}}(e,O,t,c,p,m,F,V);se.lines.skipMultiLineCalculation=!0,se.linesDf.col(ee).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const oe=new k(W,r[0],r[1],se.lines,I.none),ae=w?w(se.linesDf,re).sort([ee],[!1]):se.linesDf.plot.grid().sort([ee],[!1]);ae.col(ne)&&(ae.col(ne).visible=!1),e.temp[".cliffsDfGrid"]=ae;const ce=o.button(`${se.linesDf.rowCount} cliffs`,(()=>{v&&B.addViewer(ae),B.dockManager.dock(ae,"down",null,"Activity cliffs",b??.2)}));ce.classList.add("scatter_plot_link","cliffs_grid"),W.root.append(ce);const le=o.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(W.dataFrame.setTag(ie,r[0]),e.filter.and(D),J.next(r[0])):(W.dataFrame.setTag(ie,""),e.filter.setAll(!0),J.next(""))}});le.root.classList.add("scatter_plot_link","show_only_cliffs"),W.root.append(le.root),J.subscribe((e=>{le.enabled=""===e||e===r[0]}));let ue=!1;W.onEvent("d4-before-draw-scene").subscribe((t=>{ue?ue=!1:le.value&&(setTimeout((()=>{e.filter.and(D)}),100),ue=!0)}));const de=s.events.onViewerClosed.subscribe((e=>{e.args.viewer===W&&(B.dockManager.close(ae.root),de.unsubscribe(),B.subs=B.subs.filter((e=>e!==de)))}));return B.subs.push(de),se.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<se.linesDf.rowCount;e++)se.lines.widths[e]=e===se.linesDf.currentRowIdx?3:1;oe.linesToRender=se.lines;const n=se.linesDf.currentCol&&se.linesDf.currentCol.name===re[1]?se.lines.to:se.lines.from,i=-1!==se.linesDf.currentRowIdx?se.linesDf.currentRowIdx:null;if(W.dataFrame.currentRowIdx=i?n[i]:-1,null!==i){const n=se.linesDf.currentRowIdx;oe.currentLineId=n;const{zoomLeft:a,zoomRight:l,zoomTop:u,zoomBottom:d}=function(e,t,n,r,i,s){const o=Math.abs(n-i),a=Math.abs(r-s),c=e/o,l=t/a,u=Math.min(c,l),d=e/u*5,h=t/u*5,p=(n<i?n:i)+o/2-d/2,m=(r>s?r:s)-a/2+h/2;return{zoomLeft:p,zoomRight:p+d,zoomTop:m,zoomBottom:m-h}}(W.viewport.width,W.viewport.height,W.dataFrame.get(r[0],se.lines.from[n]),W.dataFrame.get(r[1],se.lines.from[n]),W.dataFrame.get(r[0],se.lines.to[n]),W.dataFrame.get(r[1],se.lines.to[n]));W.zoom(a,u,l,d),le.value?e.filter.and(D):!0===le.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,r,i,a,c,l,u){const d=t.getPane("Cliff Details");o.empty(d.root);const h=u({points:[n,r],lineId:i,df:e,seqCol:a,activityCol:c,sali:l});d.root.append(h),setTimeout((()=>{s.shell.o=t.root}),500)}(e,E,se.lines.from[i],se.lines.to[i],i,t,c,se.linesDf.get(ee,i),y);const n=W.dataFrame.getSortedOrder(B.grid.sortByColumns,B.grid.sortTypes);B.grid.scrollToCell(t.name,n.indexOf(W.dataFrame.currentRowIdx))}),1e3)}})),se.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<se.linesDf.rowCount;e++){const n=se.linesDf.selection.get(e);n&&(t.set(se.lines.from[e],!0),t.set(se.lines.to[e],!0)),se.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),oe.linesToRender=se.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(C?C=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<se.lines.colors.length;e++)se.lines.colors[e]="0,128,0";oe.linesToRender=se.lines})(ae.dataFrame))})),oe.lineClicked.subscribe((t=>{if(C=!0,oe.currentLineId=t.id,-1!==t.id){const n=se.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),se.linesDf.selection.copyFrom(n)):(se.linesDf.currentRowIdx!==t.id&&(se.linesDf.currentRowIdx=t.id,e.currentRowIdx=se.lines.from[t.id]),se.linesDf.selection.copyFrom(n));const r=se.linesDf.getSortedOrder(ae.sortByColumns,ae.sortTypes);ae.scrollToCell(re[0],r.indexOf(t.id))}),500)}})),oe.lineHover.pipe((0,M.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(g({lineId:n.id,points:[se.lines.from[n.id],se.lines.to[n.id]],df:e,seqCol:t,activityCol:c}),n.x,n.y)})),W.addProperty("similarityLimit","double",A),E=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),s.shell.o=e.root,e}(),W}var oe,ae=n(2003),ce=n(826),le=n(3516),ue=n(6718),de=n(2738),he=n(3077);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(oe||(oe={}));var pe,me,fe,ge=n(9192),ye=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function we(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function be(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(pe||(pe={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(me||(me={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(fe||(fe={})),Object.prototype.toString,n(6873);var ve=n(4356),Ae=(n(6717),n(4870),n(1991)),Ee=n.n(Ae),Ce=n(9322);const Te="#808080",Se="rgb(0,0,0)",_e=Ce.zS;var xe,Pe;(xe||(xe={})).maxMonomerLength=".mm.cellRenderer.maxMonomerLength",function(e){e.MSA="MSA",e.classic="classic"}(Pe||(Pe={}));const Me=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=Pe.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function $e(e,t,n,r,i,s,o){var a,c,l;const u=Object.assign(Object.assign({},Me),o);o.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let d=t.substring(0),h=u.last?"":u.separator;u.drawStyle===Pe.MSA&&(h="");let p=!0,m=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(p=u.gridCell.cell.column.temp["color-code"]??!0,m=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];m&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=d==e?.3:u.transparencyRate),m&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=d!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(d=_e(d,u.maxLengthOfMonomer));const g=d+h;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));let w=u.monomerTextSizeMap[d].width;const b=s/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));const v=u.monomerTextSizeMap[h].width;function A(t,i){const s=p?u.color:Se;e.fillStyle=s,e.globalAlpha=u.transparencyRate,u.drawStyle===Pe.classic&&(e.fillText(d,n+t,r+b),e.fillStyle=Te,e.fillText(h,n+i,r+b)),u.drawStyle===Pe.MSA&&e.fillText(d,n+t,r+b)}y=y.width,u.drawStyle===Pe.MSA&&(w=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const E=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>i)return A(E,E+w),n+E+w+v;{const e=(i-y)/2;return A(e,e+w),n+E+e+w}}n(6882);var Ne=n(4152);function Le(e){const t=!Ee().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],r=t?"":" ";for(const[t,i]of Ee().enumerate(e)){let s=t;i<e.length&&(s+=`${t?"":"-"}${r}`),n.push(s)}return[n,t]}function Ie(e,t,n,r,i,s,o){const a=document.createElement("canvas"),c=a.getContext("2d");c.font="12px monospace";const l=c.measureText(Le([e]).join("")).width,u=c.measureText(Le([t]).join("")).width,d=Math.max(l,u);return a.height=o,a.width=d+4,c.font="12px monospace",c.textBaseline="top",$e(c,e,0,i-s,d,o,{color:n,pivot:0,left:!0}),$e(c,t,0,i+s,d,o,{color:r,pivot:0,left:!0}),a}ae.YI.DNA,ae.YI.RNA,ae.YI.PT,ae.YI.UN,n(6642),n(4139),ae.zS,a.GridCellRenderer,a.GridCellRenderer;var Re,Oe,ke,Ge=n(8070),He=n(4326);function De(e){const t=o.divH([],{style:{gap:"10px"}}),n=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const r=o.divText(e.activityCol.get(n).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(n)),r]))})),t}function Fe(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,r)=>{n[r]=e.activityCol.get(t)}));const r={},i=ce.GO.forColumn(e.seqCol),s=function(e,t,n,r){const i=document.createElement("canvas"),s=i.getContext("2d");return i.height=30,function(e,t,n,r,i,s,o,a,c,l){if(s.length!==o.length){const e=function(e,t){let n=0,r=0;const i=e.length>t.length?e:t,s=e.length>t.length?t:e;for(let e=0;e<s.length;e++)i[e]===s[e]&&n++;const o=i.length-s.length;for(let e=i.length-1;e>o;e--)i[e]===s[e-o]&&r++;const a=new Array(Math.abs(e.length-t.length)).fill(ce.b9[ae.Hi.FASTA]);function c(e){return n>r?e.concat(a):a.concat(e)}return e.length>t.length?t=c(Ee()(t).toArray()):e=c(Ee()(e).toArray()),{subParts1:e,subParts2:t}}(s,o);s=e.subParts1,o=e.subParts2}const u=e.measureText(Le(s).join("")),d=e.measureText(Le(o).join("")),h=Math.max(u.width,d.width);c&&(r=h+4*s.length,e.canvas.width=h+4*s.length);let p=Math.max(t,t+(r-(h+4*s.length))/2)+5;const m=Math.max(n,n+(i-28)/2);e.save(),e.beginPath(),e.rect(t,n,c?h+4*s.length:r,i),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Ne.oT.Color;"HELM"!==a&&(f=(0,ae.ny)(a.substring(a.length-2)));for(let t=0;t<s.length;t++){const n=s[t],a=o[t],c=f.get(n);if(n!=a){const s=f.get(a),o=$e(e,n,p,m-7,r,i,{color:c,pivot:0,left:!0}),u=$e(e,a,p,m+7,r,i,{color:s,pivot:0,left:!0});p=Math.max(u,o),l&&(l[t]=Ie(n,a,c,s,m,7,i))}else p=$e(e,n,p,m,r,i,{color:c,pivot:0,left:!0,transparencyRate:.5});p+=4}e.restore()}(s,0,0,0,30,Ee()(e.canonicals).toArray(),Ee()(t.canonicals).toArray(),n,!0,r),i}(i.getSplitted(e.points[0]),i.getSplitted(e.points[1]),i.units,r);return t.append(o.div(s,{style:{width:"300px",overflow:"scroll"}})),t.append(function(e){const t=o.div();if(Object.keys(e).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}(r)),t.append(Ue("Activity delta",Math.abs(n[0]-n[1]))),t.append(Ue("Cliff",e.sali)),t}function Ue(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function Ve(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ae.gp.separator,e.col(t[0]).getTag(ae.gp.separator)),e.columns.add(n);const r=e.plot.grid();return r.col(t[0]).visible=!1,r.col(t[1]).visible=!1,r}!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Re||(Re={})),new class{constructor(){this.regionTypes=[Re.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=He.fH.Entropy,this.filterSource=He.Fo.filterSource}},n(7602),n(8047),function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(Oe||(Oe={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ke||(ke={})),a.JsViewer,n(6863),n(2780),n(8115),a.JsViewer,n(1407);var Ye,Be,We=n(439);ce.b9[We.Hi.FASTA],n(5433),n(3890),n(1687),function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Ye||(Ye={}));class je{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const r=this.isWhitespace(n)?t:t-1;for(let e=0;e<r;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToAtomType(n),t[r]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let r=this.getAtomBlockIdx();for(let i=0;i<this.atomCount;i++){r=this.shiftIdxToXColumn(r);for(const s of[e,t,n])s[i]=this.parseFloatValue(r),r=this.getNextColumnIdx(r);r=this.getNextLineIdx(r)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const r=new Uint16Array(2);r[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),r[1]=this.parseIntValue(t),e[n]=r,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToBondType(n),t[r]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Ke extends je{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let r=0;r<t;r++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class qe extends Ke{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Ye.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,r]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,r)}}));const n=t.map(((e,t)=>{if(e.startsWith(Ye.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),r=n.map((e=>t[e])),i=n.map((e=>t[e+1]));r.forEach(((t,n)=>{const r=parseInt(t.split(/\s+/)[1])-1,s=parseInt(i[n].substring(1));if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,r)}));const s=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==s.length)throw new Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Ye.TYPE)&&-1!==e.indexOf(Ye.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Ye.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Ye.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Ye.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Ye.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Ye.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Ye.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class ze extends Ke{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const i=t[1];if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ze{constructor(){}static getInstance(e){if(Ze.isMolfileV2K(e))return new qe(e);if(Ze.isMolfileV3K(e))return new ze(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return qe.isValidMolfile(e)}static isMolfileV3K(e){return ze.isValidMolfile(e)}}!function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(Be||(Be={}));var Xe=n(5488),Je={};Je.styleTagTransform=E(),Je.setAttributes=w(),Je.insert=g().bind(null,"head"),Je.domAPI=m(),Je.insertStyleElement=v(),h()(Xe.A,Je),Xe.A&&Xe.A.locals&&Xe.A.locals;class Qe{source;error;_monomers={};_onChanged=new u.Subject;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){this.source=t,this.error=n,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t===ce.b9[ae.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:Ee().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ct.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=function(e){let t;switch(e){case Be.BASE:case Be.SUGAR:case Be.LINKER:case Be.NUCLEOTIDE:case"nucleotide":t="RNA";break;case Be.AA:t="PEPTIDE";break;case Be.CHEM:t="CHEM";break;case Be.BLOB:t="BLOB";break;default:t="PEPTIDE",console.warn(`Unexpected HelmType '${e}'`)}return t}(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=Ze.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateLibInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={}),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,ve.ub)().then((e=>{this.assignDuplicatePreferances(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferances(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const i=e.duplicateMonomerPreferences[n][r],s=this.duplicateMonomers[n][r].find((e=>e.lib?.source===i));s?this._monomers[n][r]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of Ee().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=o.div([],{classes:"ui-form ui-tooltip"}),r=this.getMonomer(e,t);if(r){const e=r.symbol;r.name,n.append(o.divH([o.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),o.div([r.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let i;i=r.molfile?s.chem.svgMol(r.molfile,void 0,void 0,t):r.smiles?o.divV([s.chem.svgMol(r.smiles,void 0,void 0,t),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),n.append(o.div(i,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(o.divText(r.lib?.source??"Missed in libraries"))}else n.append(o.divV([o.divText(`Monomer '${t}' of type '${e}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}class et{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,i){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=i;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,ge.AP)(e);this.error=t,this.monomers=[]}}}class tt{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nt=n(7433),rt=n.n(nt),it=n(1913),st=n.n(it);class ot{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(rt())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});st()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const i of e){const e=i.symbol??i.id??i.name??"#N/A";if(n=this.validateMonomerSchema(i),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,i,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${i.polymerType??""}-${e}`;r.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(s)}return n}}class at{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++at.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await s.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),i=JSON.parse(r),o=new ot(i);return new at(o,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(ve.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(ve.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(ve.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(ve.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(ve.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),i=await r.readAsText(t);n=JSON.parse(i);const s={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(s[t]={},o.push(t)),s[t][n]=e})),new Qe(s,t)}async loadSetFromFile(e,t,n){let r={};const i=new a.FileSource(t),s=await i.readAsText(n);r=JSON.parse(s);const o=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,i=n.polymerType,s=n.monomerType,o=n.set;return new et(e,r,i,s,o)}));return new tt(o,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(ve.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${ve.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ct.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ct.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ct.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(ve.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ct.logger.debug(`${e}, OUT`)})),Ct.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(ve.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ve.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(ve.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ve.Es.length)))}}class ct{constructor(){}static _instance;static getInstance(){return ct._instance||(ct._instance=new ct),ct._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,M.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class lt{logger;_monomerLib=new Qe({},"MAIN");_monomerSets=new tt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Ge.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++lt.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return lt.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferances(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await at.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,ve.ub)()]),i=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let s=0;const o=i.length,[a]=await Promise.all([Promise.all(i.map((e=>this.readLibrary(ve.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Qe({},e,n)})).finally((()=>{n.update(Math.round(100*++s/o),`Loading monomers ${s}/${o}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let r=0;const i=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(ve.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/i),`Loading monomers ${r}/${i}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,ve.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,ve.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new lt(Ct.logger);return e._eventManager=ct.getInstance(),e})()),e}}n(1757);var ut=n(3017),dt={};dt.styleTagTransform=E(),dt.setAttributes=w(),dt.insert=g().bind(null,"head"),dt.domAPI=m(),dt.insertStyleElement=v(),h()(ut.A,dt),ut.A&&ut.A.locals&&ut.A.locals,n(3151);new O.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),new O.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),new O.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048);new O.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),new O.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),new O.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048);var ht,pt=n(857),mt={};mt.styleTagTransform=E(),mt.setAttributes=w(),mt.insert=g().bind(null,"head"),mt.domAPI=m(),mt.insertStyleElement=v(),h()(pt.A,mt),pt.A&&pt.A.locals&&pt.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(ht||(ht={})),ht.MONOMER,a.COLUMN_TYPE.STRING,ht.SYMBOL,a.COLUMN_TYPE.STRING,ht.NAME,a.COLUMN_TYPE.STRING,ht.R_GROUPS,a.COLUMN_TYPE.STRING,ht.MONOMER_TYPE,a.COLUMN_TYPE.STRING,ht.POLYMER_TYPE,a.COLUMN_TYPE.STRING,ht.NATURAL_ANALOG,a.COLUMN_TYPE.STRING,ht.AUTHOR,a.COLUMN_TYPE.STRING,ht.CREATE_DATE,a.COLUMN_TYPE.DATE_TIME,ht.ID,a.COLUMN_TYPE.INT,ht.META,a.COLUMN_TYPE.STRING,ht.SOURCE,a.COLUMN_TYPE.STRING;var ft,gt=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};class yt{constructor(e,t,n=!1,r){var i;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>gt(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>gt(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>gt(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(i=null==r?void 0:r.autoStartFirstStep)&&void 0!==i&&i,this._progress.max=0,this._progress.value=1,yt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=o.iconFA("clock");this._isAutomatic||0===t&&(n=o.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const r=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),i=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=o.divH([n,r],"grok-tutorial-entry");this._activity.append(s,i)}}_initRoot(){var e,t,n;s.shell.windows.showContextPanel=!0,s.shell.windows.showHelp=!1;const r=s.shell.isInDemo?Array.from(s.shell.view("Browse").dockManager.rootNode.children)[0]:Array.from(s.shell.dockManager.rootNode.children)[0];this._node=s.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r,""),(null===(t=null===(e=r.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=r.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return gt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],r=this._activity.getElementsByClassName("grok-icon")[this._currentStep],i=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];r.className="grok-icon far fa-spinner-third fa-spin",i.classList.remove("hidden"),i.classList.add("visible");const c=n,l=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{yield this._steps[this._currentStep].func()}catch(e){s.shell.isInDemo=!1,console.error(e)}this._scrollTo(this._root,c.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,r,l),yield(0,Ge.cb)(l));const u=o.iconFA("check");if(r.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}if(s.shell.isInDemo){const e=s.shell.view("Browse");(null==e?void 0:e.preview)instanceof a.TableView&&(yield s.data.detectSemanticTypes(e.preview.dataFrame))}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return gt(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return gt(this,void 0,void 0,(function*(){const r=o.div([],"demo-script-countdown");t.classList.add("hidden");let i=n/1e3;const s=this._createSVGIndicator(i);r.append(s),e.prepend(r);const a=setInterval((()=>{i--,0===i&&(clearInterval(a),r.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return gt(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return gt(this,void 0,void 0,(function*(){s.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){s.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,yt.currentObject=null,s.shell.isInDemo=!1}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return gt(this,void 0,void 0,(function*(){this._initRoot(),s.shell.newView(this.name),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}yt.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(ft||(ft={})),n(8152);var wt=n(966);n(608),n(1619),n(5785),new class{tooltipHandlerTemp="tooltip-handler.Monomer"},a.GridCellRenderer;class bt{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}Map;class vt extends a.Package{_properties;_rdKitModule;get rdKitModule(){return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new bt(super.logger,e.debug)}completeInit(e){this._rdKitModule=e,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ge.AP)(e);s.shell.error(t),this.logger.error(t,void 0,n)}}n(2174),a.Widget,a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),["1","1A","1C","2","4","4A","4B","5","6"].join(ae.z1);var At=n(8754);async function Et(e,t,n,r){const i=await async function(e,t,n,r){const i=(0,he.R)(t),s=ce.GO.forColumn(t).getNewColumnFromList("ref",[n]),o=ce.GO.forColumn(s).getSplitted(0),c=r===oe.IDENTITY?function(e,t){const n=t.columns.length,r=new Array(n),i=new Array(n),s=new Array(n);for(let o=0;o<n;++o){const n=t.columns.byIndex(o);r[o]=n.getRawData(),i[o]=n.categories.indexOf("");const a=o<e.length?e.getOriginal(o):de._S;s[o]=n.categories.indexOf(a)}const o=a.Column.float("Identity",t.rowCount),c=o.getRawData();for(let n=0;n<t.rowCount;++n){c[n]=0;for(let t=0;t<e.length;++t)(r[t]?r[t][n]:0)===s[t]&&++c[n];c[n]/=e.length}return o}(o,i):r===oe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,ue.uL)(n,e)}(o,i):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${r}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,r);for(let e=0;e<i.length;e++)t.isNone(e)&&i.set(e,null,!1);return i}Ce.Mu,n(8312),n(9124),OCL,n(6956);const Ct=new vt;async function Tt(){return await lt.getInstance()}let St=null;function _t(){return St}async function xt(e,t,n,r,i,u,d,h,p){if(!(0,wt.V)(t,"Activity Cliffs"))return;const m=we(e),f={units:t.meta.units,aligned:t.getTag(ae.gp.aligned),separator:t.getTag(ae.gp.separator),alphabet:t.getTag(ae.gp.alphabet)},g=u,y=t,w=async()=>await se(e,y,m,"Activity cliffs",n,r,g,i,{...h??{}},a.SEMTYPE.MACROMOLECULE,f,d,De,Fe,Ve,void 0,p),b=i===l.c.UMAP?2e5:2e4,v=i===l.c.UMAP?5e3:2e3;if(e.rowCount>b)return void s.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${b}`);const A=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>v&&!h?.[c.vb]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{w().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():w().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,ge.AP)(e);throw Ct.logger.error(t,void 0,n),e})).finally((()=>{A.close()}))}async function Pt(e,t,r,i,l,u,d,h,p){const m=p?s.shell.view("Browse").preview:s.shell.tv.dataFrame==e?s.shell.tv:void 0;if((0,wt.V)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),d??={},await async function(e,t,r,i,l,u,d,h=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={}){const w={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==i.length||t.length!==u.length||t.length!==l.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const b=h?f.tableView??s.shell.tableView(e.name)??s.shell.addTableView(e):null,v=async()=>{const v=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const E=we(e);function C(n,i,s){let l=null,u=null;e.columns.names().includes(E[0])?(l=e.columns.byName(E[0]),u=e.columns.byName(E[1])):(l=e.columns.add(a.Column.float(E[0],e.rowCount)),u=e.columns.add(a.Column.float(E[1],e.rowCount)),h&&!A&&(A=b.scatterPlot({...w,x:E[0],y:E[1],title:f.scatterPlotName??be(t,r)}))),f[c.YP]&&(A?.root&&o.setUpdateIndicator(A.root,!1),l.init((e=>s[0]?s[0][e]:void 0)),u.init((e=>s[1]?s[1][e]:void 0)));const d=n/i*100;v.update(d,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${d.toFixed(0)}%`)}async function T(){e.columns.add(a.Column.float(E[0],e.rowCount)),e.columns.add(a.Column.float(E[1],e.rowCount));let n=null;h&&(A=b.scatterPlot({...w,x:E[0],y:E[1],title:f.scatterPlotName??be(t,r)}),o.setUpdateIndicator(A.root,!0));const p=s.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(s.events.fireCustomEvent(G,{}),p.unsubscribe(),n?.(),v.close())})),g=new Promise((async(e,s)=>{try{n=e;const s=[];for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const r=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:c}=await n.apply({[r]:t[e],[o]:i[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:c}),m.distanceFnArgs.push(c)}else{const n=t[e].toList(),r={};s.push({entries:n,options:r}),m.distanceFnArgs.push(r)}}e(await U(s.map((e=>e.entries)),r,i,l,d,m,f[c.vb]?void 0:C))}catch(e){s(e)}})),y=await g;return v.close(),p.unsubscribe(),y}const S=await T();if(p&&S){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const x=await function(e,t,r,i){return ye(this,void 0,void 0,(function*(){return new Promise((function(s,o){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:i,epsilon:r}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):s(t)}}))}))}(S[0],S[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),P=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(P).init((e=>x[e].toString())),A&&(A.props.colorColumnName=P)}catch(M){s.shell.error("Clustering embeddings failed"),console.error(M)}finally{_.close()}}if(S){const $=e.columns.byName(E[0]),N=e.columns.byName(E[1]);if($.init((e=>S[0][e])),N.init((e=>S[1][e])),g)try{const L=g.inputs[0].name,I=g.inputs[1].name;await g.prepare({[L]:$,[I]:N,...y}).call(!0)}catch(R){s.shell.error("Post-processing failed"),console.error(R)}if(A)return o.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(O){s.shell.error("Dimensionality reduction failed"),console.error(O),v.close(),A&&o.setUpdateIndicator(A.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[c.vb])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await v();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await v();t(e)}}catch(e){n(e)}}))}(e,[t],r,[i],[1],[u],"MANHATTAN",l,h??!1,{...d,preprocessingFuncArgs:[d.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:d?.[c.vb],tableView:m})}async function Mt(e,t,n){const r=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const r=(await Tt()).getMonomerLib();await(0,At.V)(e,t,n,r)}finally{r.close()}}function $t(e){return new le.m(e).importFasta()}function Nt(e){const t=ce.GO.forColumn(e).stats;return Object.keys(t.freq)}async function Lt(e,t,n){return Et(e,t,n,oe.IDENTITY)}async function It(e,t,n){return Et(e,t,n,oe.SIMILARITY)}},8115:(e,t,n)=>{"use strict";n.d(t,{if:()=>l,nI:()=>c});var r=n(4328),i=(n(7389),n(6082)),s=n(1407),o=(n(4870),n(8070)),a=n(2003);function c(e,t,n){const r=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),r=e.charAt(0)===t,i=e.charAt(e.length-1)===t,s=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return r?i?`${n}${s}${n}`:`${n}${s}${n}|${n}${s}$`:i?`^${s}${n}|${n}${s}${n}`:`^${s}${n}|${n}${s}${n}|${n}${s}$`}(e,n):e,s=i.BitSet.create(t.length);for(let n=0;n<t.length;n++){const i=t.get(n);(i.match(r)||i===e)&&s.set(n,!0,!1)}return s}async function l(e,t){t.version!==t.temp["last-invalidated-version"]&&await async function(e){const t=i.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,o.cb)(10);const t=new Map,n=await(0,s.R)(e,!0,t);e.temp["monomeric-mols"]=n,e.temp["monomers-dict"]=t,e.temp["last-invalidated-version"]=e.version}finally{t.close()}}(t);const n=i.Column.string("helm",1).init((t=>e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=a.Hi.HELM;const c=await(0,s.R)(n,!0,t.temp["monomers-dict"]);return(await r.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:c.get(0),molBlockFailover:""})).get(0)}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>o,l:()=>a});var r=n(4328),i=n(6082),s=n(826);function o(e,t,n=[],i=[],s=!0){const[o,c]=a(e,t,n,i);return s&&!o&&r.shell.warning(c),o}function a(e,t,n=[],o=[]){let a=!0,c="";const l=s.GO.forColumn(e);if(e.semType!==i.SEMTYPE.MACROMOLECULE)r.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=l.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))c=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!l.isHelm()){const e=l.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(c=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,c]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>d,J:()=>l,b9:()=>u,gN:()=>a,uF:()=>s});var r,i,s,o=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(r||(r={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(i||(i={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(s||(s={}));const a="MSA";var c,l;!function(e){e.CELL_CHANGING="isCellChanging"}(c||(c={})),function(e){e.SEPARATOR="."}(l||(l={}));const u="3.3.1",d={pepsea:{gapOpen:1.53,gapExtend:0,method:o.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{r:()=>s}),n(6082),n(7389);var r=n(4328),i=(n(1757),n(2003),n(826));async function s(e,t,n){const s=i.GO.forColumn(e).convert(t,n);e.dataFrame.columns.add(s);const o=await r.functions.call("Bio:detectMacromolecule",{col:s});return o&&(s.semType=o),await r.data.detectSemanticTypes(e.dataFrame),s}},6740:(e,t,n)=>{"use strict";n.d(t,{m8:()=>o});var r=n(4328),i=n(8070),s=n(8152);async function o(e=6e4){const t=await s.Nk.getDockerContainer();await async function(e,t=6e4){let n=e,s=!1;for(let o=0;o<t/200;++o){if(null===n&&(n=await r.dapi.docker.dockerContainers.find(e.id)),a(n)){s=!0;break}switch(n.status){case"stopped":await r.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,i.cb)(200)}if(!s)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>r});const r="H"},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>M});var r=n(4328),i=n(6082),s=n(7389),o=n(8070),a=n(2003),c=n(826),l=n(608),u=n(8152),d=n(966),h=n(4139),p=n(6740),m=n(567),f=n(5072),g=n.n(f),y=n(7825),w=n.n(y),b=n(7659),v=n.n(b),A=n(5056),E=n.n(A),C=n(540),T=n.n(C),S=n(1113),_=n.n(S),x=n(6369),P={};async function M(e={}){return new Promise((async(t,n)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const a=e.col?.dataFrame??r.shell.t,c=e.col??a.columns.bySemType(i.SEMTYPE.MACROMOLECULE);if(null==c){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return r.shell.warning(e),void n(new l.Ap(s.divText(e)))}const d=s.input.choice("Method",{value:e.pepsea.method,items:u.ZY});d.setTooltip("Alignment method");const p=s.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const m=s.p(`Kalign version: ${h.b9}`,"kalign-version"),f=s.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const g=s.input.float("Gap extend",{value:e.pepsea.gapExtend});g.setTooltip("Gap extension penalty to skip the alignment");const y=s.inputs([f,g,p]),w=s.button("Alignment parameters",(()=>{y.hidden=!y.hidden,[f,g,p].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),y.hidden=!0,w.prepend(s.icons.settings((()=>null)));const b=[d.root.style],v=[p.root.style,m.style];let A,E=c;const C=s.input.column("Sequence",{table:a,value:c,onValueChanged:async e=>{if(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,o.cb)(0),void(C.value=E);E=e,_.disabled=!1,A=await N(C.value,a,b,v,d,T,f,g,p)},filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE});C.setTooltip("Sequences column to use for alignment");const T=s.input.column("Clusters",{table:a,value:e.clustersCol});T.nullable=!0;const S=s.dialog("MSA").add(C).add(T).add(d).add(y).add(w).add(m).onOK((async()=>{await $(C,a,A,t,n)})),_=S.getButton("OK");if(C.fireChanged(),e.col)return A=await N(e.col,a,b,v,d,T,f,g,p),void await $(C,a,A,t,n);S.show()}))}async function $(e,t,n,s,o){let a=null;const c=i.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return o("PepSeA container has not started");t.columns.add(a),await r.data.detectSemanticTypes(t),s(a)}catch(e){o(e)}finally{c.close()}}async function N(e,t,n,s,o,f,g,y,w){try{if(e.semType!==i.SEMTYPE.MACROMOLECULE)return;const r=t.columns.getUnusedName(`msa(${e.name})`);if((0,d.V)(e,e.name,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT],!1)){L(n,s,"kalign"),g.value=null,y.value=null,w.value=null;const t=c.GO.forColumn(e),i=t.isFasta()?e:t.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(i,!1,r,f.value)}if((0,d.V)(e,e.name,[a.Hi.HELM],[],!1))return L(n,s,"pepsea"),g.value??=h.HX.pepsea.gapOpen,y.value??=h.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(e,r,o.value,g.value,y.value,f.value));if((0,d.V)(e,e.name,[a.Hi.SEPARATOR],[a.YI.UN],!1)){const t=c.GO.forColumn(e).convert(a.Hi.HELM);return L(n,s,"pepsea"),g.value??=h.HX.pepsea.gapOpen,y.value??=h.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(t,r,o.value,g.value,y.value,f.value))}return g.value=null,y.value=null,w.value=null,void L(n,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();r.shell.error(t),m._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}P.styleTagTransform=_(),P.setAttributes=E(),P.insert=v().bind(null,"head"),P.domAPI=w(),P.insertStyleElement=T(),g()(x.A,P),x.A&&x.A.locals&&x.A.locals},608:(e,t,n)=>{"use strict";n.d(t,{Ap:()=>G,aZ:()=>U,eE:()=>D});var r=n(7389),i=n(6082),s=n(1991),o=n.n(s),a=n(3516),c=n(2003);const l=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),d=Symbol("Comlink.releaseProxy"),h=Symbol("Comlink.thrown"),p=e=>"object"==typeof e&&null!==e||"function"==typeof e,m=new Map([["proxy",{canHandle:e=>p(e)&&e[l],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>p(e)&&h in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(r){if(!r||!r.data)return;const{id:i,type:s,path:o}=Object.assign({path:[]},r.data),a=(r.data.argumentList||[]).map(T);let c;try{const t=o.slice(0,-1).reduce(((e,t)=>e[t]),e),n=o.reduce(((e,t)=>e[t]),e);switch(s){case"GET":c=n;break;case"SET":t[o.slice(-1)[0]]=T(r.data.value),c=!0;break;case"APPLY":c=n.apply(t,a);break;case"CONSTRUCT":c=function(e){return Object.assign(e,{[l]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),c=function(e,t){return E.set(e,t),e}(t,[t])}break;case"RELEASE":c=void 0;break;default:return}}catch(e){c={value:e,[h]:0}}Promise.resolve(c).catch((e=>({value:e,[h]:0}))).then((e=>{const[r,o]=C(e);t.postMessage(Object.assign(Object.assign({},r),{id:i}),o),"RELEASE"===s&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return b(e,[],t)}function w(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,t=[],n=function(){}){let r=!1;const i=new Proxy(n,{get(n,s){if(w(r),s===d)return()=>S(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),r=!0}));if("then"===s){if(0===t.length)return{then:()=>i};const n=S(e,{type:"GET",path:t.map((e=>e.toString()))}).then(T);return n.then.bind(n)}return b(e,[...t,s])},set(n,i,s){w(r);const[o,a]=C(s);return S(e,{type:"SET",path:[...t,i].map((e=>e.toString())),value:o},a).then(T)},apply(n,i,s){w(r);const o=t[t.length-1];if(o===u)return S(e,{type:"ENDPOINT"}).then(T);if("bind"===o)return b(e,t.slice(0,-1));const[a,c]=A(s);return S(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},c).then(T)},construct(n,i){w(r);const[s,o]=A(i);return S(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:s},o).then(T)}});return i}function v(e){return Array.prototype.concat.apply([],e)}function A(e){const t=e.map(C);return[t.map((e=>e[0])),v(t.map((e=>e[1])))]}const E=new WeakMap;function C(e){for(const[t,n]of m)if(n.canHandle(e)){const[r,i]=n.serialize(e);return[{type:"HANDLER",name:t,value:r},i]}return[{type:"RAW",value:e},E.get(e)||[]]}function T(e){switch(e.type){case"HANDLER":return m.get(e.name).deserialize(e.value);case"RAW":return e.value}}function S(e,t,n){return new Promise((r=>{const i=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==i||(e.removeEventListener("message",t),r(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:i},t),n)}))}const _="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{e.stdout+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{stdout:i}})},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";e[s]+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{[s]:i}})}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",x=typeof window<"u"&&window.Blob&&new Blob([atob(_)],{type:"text/javascript;charset=utf-8"});function P(){const e=x&&(window.URL||window.webkitURL).createObjectURL(x);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+_)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const M={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class ${constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},M,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new P;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class L{static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}L.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class I{constructor(e="categorial"){this.aa2num=L.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const r=["NH2","COOH"];if(e.startsWith(r[0])){const n=r[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${r[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(r[1])){const t=r[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${r[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return I._dropDefises(I._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let r=0;r<t;++r){const t=e[r];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[r]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const r=e[n];(0,N.vA)(r in this.num2aa,`Unknown code '${r}' found in vector '${e}'`),t+=this.num2aa[r]}return t}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function H(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function D(e,t=!1,n="",r=null,s,o,l){let u=e.toList();t&&(u=u.map((e=>I.clean(e).replace(/\-/g,""))));const d=e.length;r??=i.Column.string("Clusters",d).init("0"),r.type!=i.COLUMN_TYPE.STRING&&(r=r.convertTo(i.TYPE.STRING)),r.compact();const h=r.categories,p=r.getRawData(),m=new Array(h.length),f=new Array(h.length);for(let e=0;e<d;++e){const t=p[e];(m[t]??=[]).push(u[e]),(f[t]??=[]).push(e)}U(f,h);const g=await new $(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=i.Column.string(n,d);for(let e=0;e<h.length;++e){const t=H(m[e]);await g.fs.writeFile(O,t);const n=`${void 0!==s?` --gpo ${s}`:""}${void 0!==o?` --gpe ${o}`:""}${void 0!==l?` --tgpe ${l}`:""}`,r=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(r);const i=await g.cat(k);if(!i){const e=F(r,1);throw new Error(e)}const c=new a.m(i).sequencesArray,u=f[e];for(let e=0;e<c.length;++e)y.set(u[e],c[e])}const w=e.meta.units,b=e.getTag(c.gp.alphabet);return y.meta.units=w,y.setTag(c.gp.aligned,"SEQ.MSA"),y.setTag(c.gp.alphabet,b),y.semType=i.SEMTYPE.MACROMOLECULE,y}function F(e,t){const n=[],r=/^.+ERROR : (.+)$/gm;let i;for(;null!=(i=r.exec(e))&&(void 0===t||n.length<t);)n.push(i[1]);return n.join("\n")}function U(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=r.div([r.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...o()(n).take(3).map((e=>{let i=t[e];return i.length>25&&(i=i.slice(0,25)+"..."),r.divText(`"${i}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[r.divText("...")]:[]]);throw new G(e)}}},8152:(e,t,n)=>{"use strict";n.d(t,{GD:()=>h,Nk:()=>l,ZY:()=>u});var r=n(4328),i=n(6082),s=n(2003),o=n(608),a=n(4139),c=n(567);const l=new class{dcName="bio";async getDockerContainer(){return await r.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],d=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(e,t,n="ginsi",r=1.53,c=0,u=null,h){const m=await l.getDockerContainer();if("started"!==m.status&&"checking"!==m.status)throw new Error("PepSeA container has not started yet");const f=e.length;u??=i.Column.int("Clusters",f).init(0),u.type!=i.COLUMN_TYPE.STRING&&(u=u.convertTo(i.TYPE.STRING));const g=u.categories,y=u.getRawData(),w=new Array(g.length),b=new Array(g.length);for(let t=0;t<f;++t){const n=y[t],r=g[n];if(""===r)continue;const i=g.indexOf(r),s=e.get(t);s&&((w[i]??=[]).push({ID:t.toString(),HELM:s}),(b[n]??=[]).push(t))}(0,o.aZ)(b,g);const v=new Array(f);for(const e of w){const t=(await p(m.id,e,n,r,c,h)).Alignment;for(const e of t)v[parseInt(e.ID)]=Object.entries(e).filter((e=>!d.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.J.SEPARATOR)}const A=i.Column.fromStrings(t,v);return A.meta.units=s.Hi.SEPARATOR,A.setTag(s.gp.separator,a.J.SEPARATOR),A.setTag(s.gp.aligned,"SEQ.MSA"),A.setTag(s.gp.alphabet,s.YI.UN),A.setTag(s.gp.alphabetIsMultichar,"true"),A.semType=i.SEMTYPE.MACROMOLECULE,A}async function p(e,t,n,i,s,o){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},l=`/align?method=${n}&gap_open=${i}&gap_extend=${s}`;let u;if("fetchProxy"in r.dapi.docker.dockerContainers){const t=window.performance.now(),n=await r.dapi.docker.dockerContainers.fetchProxy(e,l,a),i=window.performance.now();c._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${i-t} ms`);const s="application/json"===n.headers.get("content-type");if(!n.ok&&s){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const r=e["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`);throw new Error(n.statusText)}if(!n.ok&&!s){const e=await n.text();throw new Error(`Error: ${e}`)}if(!s){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await r.dapi.docker.dockerContainers.request(e,l,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const i=u["datagrok-error"];if(i)throw new Error(`Datagrok error: ${i}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];o?.warning(e)}return u}},3890:(e,t,n)=>{"use strict";n.d(t,{aS:()=>c,wz:()=>a}),n(6082),n(7389),n(4328);var r=n(1991),i=n.n(r),s=n(826);const o=60;function a(e,t,n=o,r="\n"){const i=s.GO.forColumn(t),a=[];for(let s=0;s<t.length;s++){const t=e.map((e=>e.get(s).toString())).join("|"),o=c(i.getSplitted(s),n);a.push(`>${t}${r}`);for(const e of o)a.push(`${e}${r}`)}return"".concat(...a)}function c(e,t=o){let n=0;const r=e.length,s=[];for(;n<r;){const r=i()(e.originals).slice(n,n+t).toArray(),o=r.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");s.push(o),n+=r.length}return s}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var r=n(4328),i=n(7384),s=n(826),o=n(2003),a=n(6717),c=n(8312),l=n(966);async function u(e,t,n,u){let d;try{d=await(0,a.j)()}catch(e){return r.shell.warning('Transformation to atomic level requires package "Chem" installed.'),null}let h=null;if(n){const n=await(0,c.Q)(),r=s.GO.forColumn(t);let i,a,l;r.isHelm()?a=t:(l=t.name,t.name=`__${l}`,a=r.convert(o.Hi.HELM),a.name=l,e.columns.add(a,!1));try{i=await n.helmToAtomicLevel(a,!0,!0)}finally{a!==t&&(e.columns.remove(a.name),t.name=l)}e.columns.add(i.molCol),e.columns.add(i.molHighlightCol),h=i.molCol}else{if(!(0,l.V)(t,"To Atomic Level"))return null;const n=await(0,i.C4)(e,t,u);null!==n.col&&(e.columns.add(n.col,!0),h=n.col)}return h&&await r.data.detectSemanticTypes(e),h}},5785:(e,t,n)=>{"use strict";n.d(t,{k:()=>u});var r=n(4328),i=n(6082),s=n(8070),o=n(966),a=n(3077),c=n(4139),l=n(439);async function u(e,t){if(await(0,s.cb)(10),!(0,o.V)(t,"Sequence space"))return e;const n=(0,a.R)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=c.uF.MONOMER,e.setTag(l.gp.alphabet,t.getTag(l.gp.alphabet));const d=/(\d+)(?: \((\d+)\))?/,h=e=>{d.lastIndex=0;const t=e.match(d);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const r=n.columns.byIndex(e);r.semType=c.uF.MONOMER,r.setTag(l.gp.alphabet,t.getTag(l.gp.alphabet));const i=100;let s=0;for(;u.columns.byName(r.name)&&s<i;)r.name=h(r.name),s++;u.columns.add(r)}await r.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(i.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4870:(e,t,n)=>{"use strict";function r(e,t){e.innerHTML="",e.append(t)}n.d(t,{K:()=>r}),n(4328),n(6082)},8047:(e,t,n)=>{"use strict";n.d(t,{VN:()=>p,n5:()=>c,Ue:()=>h,Tc:()=>d,eN:()=>m}),n(4328),n(7389);var r=n(6082),i=(n(1757),n(1991),n(1858),n(826),n(2003)),s=n(4326),o=n(2738);n(8070),n(7602);var a,c,l,u=n(2174);n(567),HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class d{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class h{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,r){this.pos=e,this.name=t,this._freqs=n??{},r?.sumRowCount&&(this.sumRowCount=r.sumRowCount),r?.sumValueForHeight&&(this.sumPlotValue=r.sumValueForHeight),r?.label&&(this._label=r.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new d),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===s.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const r=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-r*Math.log2(r)}}else if(e===s.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,a,c,l,u,d){const h=i===s.fH.Entropy?n*(a-this.sumPlotValueForHeight)/a:n;let p=d*u+(n-h-1);const m=Object.entries(this._freqs).sort(((e,t)=>e[0]!==o._S&&t[0]!==o._S?t[1].value-e[1].value:e[0]===o._S&&t[0]===o._S?0:e[0]===o._S?-1:1));for(const[n,i]of m){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,s){for(const[a,c]of Object.entries(this._freqs))if(a!==o._S){const o=(0,i.zS)(a,5),l=c.bounds,u=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(u,l.top,l.width,l.height),e.fillStyle=s.get(a)??s.get("other"),e.textAlign="left",e.font=t;const d=e.measureText(o);e.setTransform(l.width/d.width,0,0,l.height/r,u,l.top),e.fillText(o,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,u.F)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(a||(a={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(c||(c={})),s.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(l||(l={}));const p=new class{render=20};function m(e,t,n,r,i){let s=0,o=-1;for(;-1!=(o=n.findNext(o,!0));){const e=t.getSplitted(o),n=i.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&s++}return s}r.JsViewer},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>o,n:()=>s});var r=n(1858),i=n(567);class s{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(i._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{onChanged=new r.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>S,AR:()=>T});var r=n(7389),i=n(6082),s=n(4328),o=n(1991),a=n.n(o),c=n(1858),l=n(2003),u=n(8070),d=n(826),h=n(7602),p=n(8115),m=n(4577),f=n(1757),g=n.n(f),y=n(9124),w=n(9192),b=n(4870),v=n(567);class A extends m.O{emptyProps=new m.n("");helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++A.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,y.b)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,w.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,w.AP)(e),i=this._filterPanel;i.innerText="error",i.classList.add("d4-error"),r.tooltip.bind(i,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,b.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}const E="bio-substructure-filter";class C{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,i){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=i}}class T extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class S extends i.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++S.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(i.SEMTYPE.MACROMOLECULE)),d.GO.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new _:this.notation===l.Hi.SEPARATOR?new x(this.column.getTag(l.gp.separator)):new A,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(i.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(E).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=i.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(E,new C(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class x extends m.O{emptyProps=new T("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new T(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("")}get filterPanel(){return r.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,p.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>v});var r=n(7389),i=n(6082),s=(n(1991),n(2003),n(4152),n(5072)),o=n.n(s),a=n(7825),c=n.n(a),l=n(7659),u=n.n(l),d=n(5056),h=n.n(d),p=n(540),m=n.n(p),f=n(1113),g=n.n(f),y=n(5999),w={};w.styleTagTransform=g(),w.setAttributes=h(),w.insert=u().bind(null,"head"),w.domAPI=c(),w.insertStyleElement=m(),o()(y.A,w),y.A&&y.A.locals&&y.A.locals,n(826);var b=n(2738);function v(e,t){let n=0,s=null;for(const e of Object.values(t))n+=e,s=null===s?e:Math.max(s,e);const o=s/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,s])=>{const a=s/n,c=e.get(t),l=r.div("",{classes:"macromolecule-cell-comp-analysis-bar"});l.style.width=50*a/o+"px",l.style.backgroundColor=c,b._S===t&&(l.style.borderWidth="1px",l.style.borderStyle="solid",l.style.borderColor=i.Color.toHtml(i.Color.lightGray));const u=b._S===t?"-":t,d=r.div(`${(100*a).toFixed(2)}%`),h=r.div([l,d],{classes:"macromolecule-cell-comp-analysis-value"});return{[u]:h}}))),c=r.tableFromMap(a);return Array.from(c.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),c}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:r,normalizeIPv4:i,removeDotSegments:s,recomposeAuthority:o,normalizeComponentEncoding:a}=n(4834),c=n(343);function l(e,t,n,r){const i={};return r||(e=p(u(e,n),n),t=p(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(i.scheme=t.scheme,i.userinfo=t.userinfo,i.host=t.host,i.port=t.port,i.path=s(t.path||""),i.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(i.userinfo=t.userinfo,i.host=t.host,i.port=t.port,i.path=s(t.path||""),i.query=t.query):(t.path?("/"===t.path.charAt(0)?i.path=s(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?i.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:i.path=t.path:i.path="/"+t.path,i.path=s(i.path)),i.query=t.query):(i.path=e.path,void 0!==t.query?i.query=t.query:i.query=e.query),i.userinfo=e.userinfo,i.host=e.host,i.port=e.port),i.scheme=e.scheme),i.fragment=t.fragment,i}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},r=Object.assign({},t),i=[],a=c[(r.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,r),void 0!==n.path&&(r.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==r.reference&&n.scheme&&(i.push(n.scheme),i.push(":"));const l=o(n,r);if(void 0!==l&&("suffix"!==r.reference&&i.push("//"),i.push(l),n.path&&"/"!==n.path.charAt(0)&&i.push("/")),void 0!==n.path){let e=n.path;r.absolutePath||a&&a.absolutePath||(e=s(e)),void 0===l&&(e=e.replace(/^\/\//u,"/%2F")),i.push(e)}return void 0!==n.query&&(i.push("?"),i.push(n.query)),void 0!==n.fragment&&(i.push("#"),i.push(n.fragment)),i.join("")}const d=Array.from({length:127},((e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t)))),h=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(e,t){const n=Object.assign({},t),s={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},o=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const l=e.match(h);if(l){if(s.scheme=l[1],s.userinfo=l[3],s.host=l[4],s.port=parseInt(l[5],10),s.path=l[6]||"",s.query=l[7],s.fragment=l[8],isNaN(s.port)&&(s.port=l[5]),s.host){const e=i(s.host);if(!1===e.isIPV4){const t=r(e.host,{isIPV4:!1});s.host=t.host.toLowerCase(),a=t.isIPV6}else s.host=e.host,a=!0}void 0!==s.scheme||void 0!==s.userinfo||void 0!==s.host||void 0!==s.port||s.path||void 0!==s.query?void 0===s.scheme?s.reference="relative":void 0===s.fragment?s.reference="absolute":s.reference="uri":s.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==s.reference&&(s.error=s.error||"URI is not a "+n.reference+" reference.");const e=c[(n.scheme||s.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&s.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,r=e.length;n<r;++n)if(t=e.charCodeAt(n),t>126||d[t])return!0;return!1}(s.host))try{s.host=URL.domainToASCII(s.host.toLowerCase())}catch(e){s.error=s.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(o&&void 0!==s.scheme&&(s.scheme=unescape(s.scheme)),o&&void 0!==s.userinfo&&(s.userinfo=unescape(s.userinfo)),o&&void 0!==s.host&&(s.host=unescape(s.host)),void 0!==s.path&&s.path.length&&(s.path=escape(unescape(s.path))),void 0!==s.fragment&&s.fragment.length&&(s.fragment=encodeURI(decodeURIComponent(s.fragment)))),e&&e.parse&&e.parse(s,n)}else s.error=s.error||"URI can not be parsed.";return s}const m={SCHEMES:c,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const r=Object.assign({scheme:"null"},n);return u(l(p(e,r),p(t,r),r,!0),{...r,skipEscape:!0})},resolveComponents:l,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function r(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function i(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function s(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const o={scheme:"http",domainHost:!0,parse:i,serialize:s},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=r(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(r(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},c={http:o,https:{scheme:"https",domainHost:o.domainHost,parse:i,serialize:s},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const r=e.path.match(n);if(r){const n=t.scheme||e.scheme||"urn";e.nid=r[1].toLowerCase(),e.nss=r[2];const i=`${n}:${t.nid||e.nid}`,s=c[i];e.path=void 0,s&&(e=s.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",r=e.nid.toLowerCase(),i=`${n}:${t.nid||r}`,s=c[i];s&&(e=s.serialize(e,t));const o=e,a=e.nss;return o.path=`${r||t.nid}:${a}`,t.skipEscape=!0,o},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const r=e;return r.uuid=r.nss,r.nss=void 0,n.tolerant||r.uuid&&t.test(r.uuid)||(r.error=r.error||"UUID is not valid."),r},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=c},4914:e=>{"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(e,t,n)=>{"use strict";const{HEX:r}=n(4914);function i(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(/^(?:(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])\.){3}(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])$/u)||[],[n]=t;return n?{host:a(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function s(e,t=!1){let n="",i=!0;for(const t of e){if(void 0===r[t])return;"0"!==t&&!0===i&&(i=!1),i||(n+=t)}return t&&0===n.length&&(n="0"),n}function o(e,t={}){if(c(e,":")<2)return{host:e,isIPV6:!1};const n=function(e){let t=0;const n={error:!1,address:"",zone:""},r=[],i=[];let o=!1,a=!1,c=!1;function l(){if(i.length){if(!1===o){const e=s(i);if(void 0===e)return n.error=!0,!1;r.push(e)}i.length=0}return!0}for(let s=0;s<e.length;s++){const u=e[s];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!l())break;o=!0}else i.push(u);else{if(!0===a&&(c=!0),!l())break;if(t++,r.push(":"),t>7){n.error=!0;break}s-1>=0&&":"===e[s-1]&&(a=!0)}}return i.length&&(o?n.zone=i.join(""):c?r.push(i.join("")):r.push(s(i))),n.address=r.join(""),n}(e);if(n.error)return{host:e,isIPV6:!1};{let e=n.address,t=n.address;return n.zone&&(e+="%"+n.zone,t+="%25"+n.zone),{host:e,escapedHost:t,isIPV6:!0}}}function a(e,t){let n="",r=!0;const i=e.length;for(let s=0;s<i;s++){const o=e[s];"0"===o&&r?(s+1<=i&&e[s+1]===t||s+1===i)&&(n+=o,r=!1):(r=o===t,n+=o)}return n}function c(e,t){let n=0;for(let r=0;r<e.length;r++)e[r]===t&&n++;return n}const l=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,h=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e,t){const n=[];if(void 0!==e.userinfo&&(n.push(e.userinfo),n.push("@")),void 0!==e.host){let t=unescape(e.host);const r=i(t);if(r.isIPV4)t=r.host;else{const n=o(r.host,{isIPV4:!1});t=!0===n.isIPV6?`[${n.escapedHost}]`:e.host}n.push(t)}return"number"!=typeof e.port&&"string"!=typeof e.port||(n.push(":"),n.push(String(e.port))),n.length?n.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(l))e=e.replace(l,"");else if(e.match(u))e=e.replace(u,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(h);if(!n)throw new Error("Unexpected dot segment condition");{const r=n[0];e=e.slice(r.length),t.push(r)}}return t.join("")},normalizeIPv4:i,normalizeIPv6:o,stringArrayToHexStripped:s}},3837:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(r){var i=t[r];if(void 0!==i)return i.exports;var s=t[r]={id:r,loaded:!1,exports:{}};return e[r].call(s.exports,s,s.exports,n),s.loaded=!0,s.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var r=t.getElementsByTagName("script");if(r.length)for(var i=r.length-1;i>-1&&(!e||!/^http(s?):/.test(e));)e=r[i--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var r={};(()=>{"use strict";n.r(r),n.d(r,{_package:()=>_e,test:()=>xe,tests:()=>t.CN});var e=n(6082),t=n(8070);(0,t.L1)("_first",(()=>{(0,t.t6)("_first",(async()=>{}))}));var i=n(8924),s=n(7362),o=n(1093);(0,t.L1)("Palettes",(()=>{(0,t.t6)("testPaletteN",(async()=>{await async function(){const e=o.A.Chromatogram;(0,t.E3)(e instanceof s.e,!0),(0,t.E3)(e instanceof o.A,!0)}()})),(0,t.t6)("testPaletteAA",(async()=>{await async function(){const e=i.X.Lesk,n=i.X.RasMol,r=i.X.GrokGroups;(0,t.E3)(e instanceof s.e,!0),(0,t.E3)(n instanceof s.e,!0),(0,t.E3)(r instanceof s.e,!0),(0,t.E3)(e instanceof i.X,!0),(0,t.E3)(n instanceof i.X,!0),(0,t.E3)(r instanceof i.X,!0)}()})),(0,t.t6)("testPalettePtMe",(async()=>{const e=i.X.GrokGroups.get("MeNle"),n=i.X.GrokGroups.get("MeA"),r=i.X.GrokGroups.get("MeG"),s=i.X.GrokGroups.get("MeF"),o=i.X.GrokGroups.get("L"),a=i.X.GrokGroups.get("A"),c=i.X.GrokGroups.get("G"),l=i.X.GrokGroups.get("F");(0,t.E3)(e,o),(0,t.E3)(n,a),(0,t.E3)(r,c),(0,t.E3)(s,l)}))}));var a=n(4328),c=n(567),l=n(2003),u=n(826);class d{units;aligned;alphabet;alphabetSize;alphabetIsMultichar;separator;constructor(e,t,n,r,i,s){this.units=e,this.aligned=t,this.alphabet=n,this.alphabetSize=r,this.alphabetIsMultichar=i,this.separator=s}}async function h(t){const n=e.Column.fromList(e.TYPE.STRING,"col1",t);if(await a.functions.call("Bio:detectMacromolecule",{col:n}),n.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${n.semType}', units='${n.meta.units}'.`;throw new Error(e)}}async function p(t,n){const r=(await t()).getCol(n),i=await a.functions.call("Bio:detectMacromolecule",{col:r});if(i&&(r.semType=i),r.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${r.semType}', units='${r.meta.units}'.`;throw new Error(e)}}async function m(n,r,i,s,o,c,d=null){const h=e.Column.fromList(e.TYPE.STRING,"seq",n),p=await a.functions.call("Bio:detectMacromolecule",{col:h});p&&(h.semType=p),(0,t.E3)(h.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(h.meta.units,r),(0,t.E3)(h.getTag(l.gp.aligned),i),(0,t.E3)(h.getTag(l.gp.alphabet),s),d&&(0,t.E3)(h.getTag(l.gp.separator),d);const m=u.GO.forColumn(h);(0,t.E3)(m.getAlphabetSize(),o),(0,t.E3)(m.getAlphabetIsMultichar(),c),m.isHelm()||((0,t.E3)(m.aligned,i),(0,t.E3)(m.alphabet,s))}async function f(n,r,i,s,o,c,d,h=null){const p=(await n()).col(r),m=await a.functions.call("Bio:detectMacromolecule",{col:p});m&&(p.semType=m),(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,i),(0,t.E3)(p.getTag(l.gp.aligned),s),(0,t.E3)(p.getTag(l.gp.alphabet),o),h&&(0,t.E3)(p.getTag(l.gp.separator),h);const f=u.GO.forColumn(p);(0,t.E3)(f.getAlphabetSize(),c),(0,t.E3)(f.getAlphabetIsMultichar(),d),f.isHelm()||((0,t.E3)(f.aligned,s),(0,t.E3)(f.alphabet,o))}async function g(e,t){const n=await e(),r=[];for(const i of n.columns.names())if(i in t){const n=t[i];try{await f(e,i,n.units,n.aligned,n.alphabet,n.alphabetSize,n.alphabetIsMultichar,n.separator)}catch(e){const t=e.toString();r.push(`Positive col '${i}' failed: ${t}`)}}else try{await p(e,i)}catch(e){const t=e.toString();r.push(`Negative col '${i}' failed: ${t}`)}if(r.length>0)throw new Error(r.join("\n"))}(0,t.L1)("detectors",(()=>{const n={negEmpty:{csv:"id,col1\n1,\n2,\n3,\n4,\n5,",neg:["col1"]},negNum1:{csv:"col1\n1\n2\n3",neg:["col1"]},negNum2:{csv:"col1\n4\n5\n6\n7",neg:["col1"]},negNum3:{csv:"col1\n8\n9\n10\n11\n12",neg:["col1"]},negSmiles:{csv:"col1\nCCCCN1C(=O)CN=C(c2cc(F)ccc12)C3CCCCC3\nC1CCCCC1\nCCCCCC",neg:["col1"]},negSmilesWithSquareBrackets:{csv:"col1\nCl.c1ccc2nc3ccccc3cc2c1\nOc1cccc2cc3ccccc3cc12\n[SeH]c1ccc2ccccc2c1",neg:["col1"]},negFastaUnSingleChar:{csv:"col1\nAlanine\nCysteine\nAspartic acid\nGlutamic acid\nPhenylalanine",neg:["col1"]},fastaMsaSameLength:{csv:"seq\nFWPHEYFWPHEYYV\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1,void 0)}},fastaExtSameLength:{csv:"seq\nFW[Ac]PHEYFWPH\nYN[Re]VYNRQWYV\n[Me]EYVMPS[Et]",pos:{seq:new d(l.Hi.FASTA,"SEQ",l.YI.UN,16,!0,void 0)}},fastaMsaExtSameLength:{csv:"seq\nFW[Ac]PHEY[Re]WPH\nYN[Re]VYNR[Ac]WYV\n[Me]EYVMPSFW[Me]H",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.UN,14,!0,void 0)}},fastaMsaExtManyMinus:{csv:"seq\n[D-Tic]-------[D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]N[D-Orn][D-aThr]-[Phe_4Me]\n[Phe_2F]--------[Tyr_ab-dehydroMe][dV][Aca]N[D-Orn][D-aThr]-[Phe_4Me]\n[D-Tic]-[Hcy]QTWQ[Phe_4NH2][D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]----[Phe_4Me]",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.UN,17,!0,void 0)}},sepSameLength:{csv:"seq\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2",pos:{seq:new d(l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,5,!0,"-")}},sepMsaSameLength:{csv:"seq\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A(2)-A-A-A-C(2)-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2",pos:{seq:new d(l.Hi.SEPARATOR,"SEQ",l.YI.UN,5,!0,"-")}},helmSameLength:{csv:"seq\nPEPTIDE1{Ac(1).A.A.A.A.A.A.A.A.A.A.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ab(1).Y.V.K.H.P.F.W.R.W.Y.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ad(1).S.W.Y.C.K.H.P.M.W.A.A.A.A.C(1)-G-NH2}$$$$",pos:{seq:new d(l.Hi.HELM,null,null,19,void 0,void 0)}}};for(const[r,i]of Object.entries(n))(0,t.t6)(`csvData2-${r}`,(async()=>{const t=(s=r,async()=>{const t=n[s].csv,r=e.DataFrame.fromCsv(t);return await a.data.detectSemanticTypes(r),r});var s;for(const e of i.neg??[])await p(t,e);for(const[e,n]of Object.entries(i.pos??{}))await f(t,e,n.units,n.aligned,n.alphabet,n.alphabetSize,n.alphabetIsMultichar,n.separator)}));const r=new class{csvFastaDna1="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC";fastaRna1="seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC";fastaPt1="seq\nFWPHEY\nYNRQWYV\nMKPSEYV";fastaUn="seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]DN\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]";sepDna="seq\nA*C*G*T*C*A*C*G*T*C\nC*A*G*T*G*T*C*A*G*T*G*T\nT*T*C*A*A*C*T*T*C*A*A*C";sepRna="seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C";sepPt="seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V";sepUn1="seq\nabc-dfgg-abc1-cfr3-rty-wert-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-cfr3-wert-rut12";sepUn2="seq\nabc/dfgg/abc1/cfr3/rty/wert/abc/dfgg/abc1/cfr3/rty/wert\nrut12/her2/rty/wert//abc/abc1/dfgg/rut12/her2/rty/wert//abc/abc1/dfgg\nrut12/rty/her2/abc/cfr3//wert/rut12/rut12/rty/her2/abc/cfr3//wert/rut12";sepMsaDna1="seq\nA-C--G-T--C-T-A-C--G-T--C-T\nC-A-C--T--G-T-C-A-C--T--G-T\nA-C-C-G-T-A-C-T-A-C-C-G-T-A-C-T";sepMsaUnWEmpty="seq\nm1-M-m3-mon4-mon5-N-T-MON8-N9-m1-M-m3-mon4-mon5-N-T-MON8-N9\nm1-mon2-m3-mon4-mon5-Num--MON8-N9-m1-mon2-m3-mon4-mon5-Num--MON8-N9\n\nmon1-M-mon3-mon4-mon5---MON8-N9-mon1-M-mon3-mon4-mon5---MON8-N9";sepComplex="seq\nAc(1)-F-K(AEEA-AEEA-R-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2\nAc(1)-F-K(AEEA-ARRA-W-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2\nAc(1)-F-K(AEEA-AEEA-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2";fastaMsaDna1="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT";fastaMsaPt1="seq\nFWR-WYV-KHPFWR-WYV-KHP\nYNR-WYV-KHPYNR-WYV-KHP\nMWRSWY-CKHPMWRSWY-CKHP"},i={fastaPtCsv:"System:AppData/Bio/samples/FASTA_PT.csv",msaComplex:"System:AppData/Bio/samples/MSA.csv",fastaCsv:"System:AppData/Bio/samples/FASTA.csv",helmCsv:"System:AppData/Bio/samples/HELM.csv",peptidesComplex:"System:AppData/Bio/tests/peptides_complex_msa.csv",peptidesSimple:"System:AppData/Bio/tests/peptides_simple_msa.csv",testDemogCsv:"System:AppData/Bio/tests/testDemog.csv",testHelmCsv:"System:AppData/Bio/tests/testHelm.csv",testIdCsv:"System:AppData/Bio/tests/testId.csv",testSmilesCsv:"System:AppData/Bio/tests/testSmiles.csv",testSmiles2Csv:"System:AppData/Bio/tests/testSmiles2.csv",testSmilesShort:"System:AppData/Bio/tests/testSmilesShort.csv",testActivityCliffsCsv:"System:AppData/Bio/tests/testActivityCliffs.csv",testCerealCsv:"System:AppData/Bio/tests/testCereal.csv",testUnichemSources:"System:AppData/Bio/tests/testUnichemSources.csv",testDmvOffices:"System:AppData/Bio/tests/testDmvOffices.csv",testAlertCollection:"System:AppData/Bio/tests/testAlertCollection.csv",testSpgi100:"System:AppData/Bio/tests/testSpgi100.csv",testSpgi:"System:AppData/Bio/tests/SPGI-derived.csv",testUrl:"System:AppData/Bio/tests/testUrl.csv"},s={};function o(e,t=c){return async()=>(e in s||(s[e]=(async()=>await t(i[e]))().catch((t=>{throw delete s[e],t}))),s[e])}async function c(t){const n=await a.dapi.files.readAsText(t);return e.DataFrame.fromCsv(n)}const u=t=>async()=>{const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i};(0,t.t6)("NegativeStartEnd",(async()=>{await h(["START","END"])})),(0,t.t6)("NegativeStartEndIntermediate",(async()=>{await h(["START","END","INTERMEDIATE"])})),(0,t.t6)("FastaDna1",(async()=>{await f(u("csvFastaDna1"),"seq",l.Hi.FASTA,"SEQ",l.YI.DNA,4,!1)})),(0,t.t6)("FastaRna1",(async()=>{await f(u("fastaRna1"),"seq",l.Hi.FASTA,"SEQ",l.YI.RNA,4,!1)})),(0,t.t6)("FastaPt1",(async()=>{await f(u("fastaPt1"),"seq",l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})),(0,t.t6)("FastaPtGaps",(()=>m(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEYV"],l.Hi.FASTA,"SEQ",l.YI.PT,20,!1))),(0,t.t6)("FastaPtGapsMsa",(()=>m(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEY"],l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1))),(0,t.t6)("FastaUn",(async()=>{await f(u("fastaUn"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.UN,12,!0)})),(0,t.t6)("FastaMsaDna1",(async()=>{await f(u("fastaMsaDna1"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.DNA,4,!1)})),(0,t.t6)("FastaMsaPt1",(async()=>{await f(u("fastaMsaPt1"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1)})),(0,t.t6)("SepDna",(async()=>{await f(u("sepDna"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.DNA,4,!1,"*")})),(0,t.t6)("SepRna",(async()=>{await f(u("sepRna"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.RNA,4,!1,"*")})),(0,t.t6)("SepPt",(async()=>{await f(u("sepPt"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.PT,20,!1,"-")})),(0,t.t6)("SepUn1",(async()=>{await f(u("sepUn1"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,8,!0,"-")})),(0,t.t6)("SepUn2",(async()=>{await f(u("sepUn2"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,9,!0,"/")})),(0,t.t6)("SepMsaN1",(async()=>{await f(u("sepMsaDna1"),"seq",l.Hi.SEPARATOR,"SEQ.MSA",l.YI.DNA,4,!1,"-")})),(0,t.t6)("SepMsaUnWEmpty",(async()=>{await f(u("sepMsaUnWEmpty"),"seq",l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,14,!0)})),(0,t.t6)("SepComplex",(async()=>{await f(u("sepComplex"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,18,!0)})),(0,t.t6)("samplesFastaCsv",(async()=>{await g(o("fastaCsv"),{Sequence:new d(l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})})),(0,t.t6)("samplesPeptidesComplex",(async()=>{await g(o("peptidesComplex"),{})})),(0,t.t6)("samplesMsaComplex",(async()=>{await g(o("msaComplex"),{MSA:new d(l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,161,!0,"/")})})),(0,t.t6)("samplesIdCsv",(async()=>{await g(o("testIdCsv"),{})})),(0,t.t6)("samplesSarSmallCsv",(async()=>{await g(o("testSmilesCsv"),{})})),(0,t.t6)("samplesHelmCsv",(async()=>{await g(o("helmCsv"),{HELM:new d(l.Hi.HELM,null,null,160,!0)})})),(0,t.t6)("samplesTestHelmCsv",(async()=>{await g(o("testHelmCsv"),{"HELM string":new d(l.Hi.HELM,null,null,9,!0)})})),(0,t.t6)("samplesTestDemogCsv",(async()=>{await g(o("testDemogCsv"),{})})),(0,t.t6)("samplesTestSmiles2Csv",(async()=>{await g(o("testSmiles2Csv"),{})})),(0,t.t6)("samplesTestSmilesShort",(async()=>{await g(o("testSmilesShort"),{})})),(0,t.t6)("samplesTestActivityCliffsNegativeSmiles",(async()=>{await g(o("testActivityCliffsCsv"),{})})),(0,t.t6)("samplesFastaPtCsv",(async()=>{await g(o("fastaPtCsv"),{sequence:new d(l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})})),(0,t.t6)("samplesTestCerealCsv",(async()=>{await g(o("testCerealCsv"),{})})),(0,t.t6)("samplesTestUnichemSources",(async()=>{await g(o("testUnichemSources"),{})})),(0,t.t6)("samplesTestDmvOffices",(async()=>{await g(o("testDmvOffices"),{})})),(0,t.t6)("samplesTestAlertCollection",(async()=>{await g(o("testAlertCollection"),{})})),(0,t.t6)("samplesTestSpgi",(async()=>{await g(o("testSpgi"),{})})),(0,t.t6)("samplesTestSpgi100",(async()=>{await g(o("testSpgi100"),{})})),(0,t.t6)("samplesTestUrl",(async()=>{await g(o("testUrl"),{})}))})),(0,t.L1)("detectors:weak-and-likely",(()=>{const n={fastaDnaWeak1:"id,colName\n1,TTTTTTTTTT\n2,TTTTTTTTTT\n3,TTTTTTTTTT\n4,TTTTTTTTTT",fastaDnaWeak1LikelyName:"id,seq\n1,TTTTTTT\n2,TTTTTTT\n3,TTTTTTT\n4,TTTTTTT",fastaRnaWeak1:"id,colName\n1,UUUUUUUUUU\n2,UUUUUUUUUU\n3,UUUUUUUUUU\n4,UUUUUUUUUU",fastaRnaWeak1LikelyName:"id,seq\n1,UUUUUUU\n2,UUUUUUU\n3,UUUUUUU\n4,UUUUUUU",fastaPtWeak1:"id,colName\n1,SLSLSPGKSLSLSPGK\n2,SLSLSPGKSLSLSPGK\n3,SLSLSPGKSLSLSPGK\n4,SLSLSPGKSLSLSPGK",fastaPtWeak1LikelyName:"id,seq\n1,SLSLSPGKSLSLSPGK\n2,SLSLSPGKSLSLSPGK\n3,SLSLSPGKSLSLSPGK\n4,SLSLSPGKSLSLSPGK",fastaUn1:"id,colName\n1,word\n2,other\n3,some\n4,another",fastaUn1LikelyName:"id,seq\n1,word\n2,other\n3,some\n4,another",fastaUn2LikelyName:'protein\nBoombastic\nMegafantastic\n"just-a-random-thought,oy!"',fastaUnMsa1LikelyName:"id,seq\n1,word\n2,male\n3,bare\n4,core"},r=t=>async()=>{const r=n[t],i=e.DataFrame.fromCsv(r);return await a.data.detectSemanticTypes(i),i};(0,t.t6)("fastaDnaWeak1",(async()=>{await p(r("fastaDnaWeak1"),"colName")})),(0,t.t6)("fastaDnaWeak1LikelyName",(async()=>{await f(r("fastaDnaWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.DNA,4,!1)})),(0,t.t6)("fastaRnaWeak1",(async()=>{await p(r("fastaRnaWeak1"),"colName")})),(0,t.t6)("fastaRnaWeak1LikelyName",(async()=>{await f(r("fastaRnaWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.RNA,4,!1)})),(0,t.t6)("fastaPtWeak1",(async()=>{await p(r("fastaPtWeak1"),"colName")})),(0,t.t6)("fastaPtWeak1LikelyName",(async()=>{await f(r("fastaPtWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1)})),(0,t.t6)("fastaUn1",(async()=>{await p(r("fastaUn1"),"colName")})),(0,t.t6)("fastaUn1LikelyName",(async()=>{await p(r("fastaUn1LikelyName"),"seq")})),(0,t.t6)("fastaUn2LikelyName",(async()=>{await p(r("fastaUn2LikelyName"),"protein")})),(0,t.t6)("fastaUnMsa1LikelyName",(async()=>{await p(r("fastaUnMsa1LikelyName"),"seq")}))})),(0,t.L1)("detectorsBenchmark",(()=>{let n;async function r(r,s,o,a,c,d){return await async function(r){const h=await(async()=>{const t=function(t,n,r,i,s){let o;switch(t){case l.Hi.FASTA:o=e=>{let t="";for(let n=0;n<e.length;n++){const r=e[n];t+=1==r.length?r:`[${r}]`}return t};break;case l.Hi.SEPARATOR:o=(e,t)=>e.join(t);break;default:throw new Error(`Not supported notation '${t}'.`)}const a=(e,t)=>{const n=new Array(t);for(let r=0;r<t;r++)n[r]=e[Math.floor(Math.random()*e.length)];return o(n,s)},c=Array(i);for(let e=0;e<i;e++)c[e]=a(n,r);return e.Column.fromStrings("seq",c)}(s,[...(0,l.Qf)(o)],a,c,d),r=n.prepare({col:t});return i(r),r})(),p=Date.now(),m=i(h),f=Date.now();(function(e,n){const r=u.GO.forColumn(e);(0,t.E3)(e.semType===n.semType,!0),(0,t.E3)(r.notation===n.notation,!0),(0,t.E3)(r.alphabet===n.alphabet,!0),(0,t.E3)(r.separator===n.separator,!0)})(m,{semType:e.SEMTYPE.MACROMOLECULE,notation:s,alphabet:o,separator:d});const g=f-p;if(g>r){const e=`ET ${g} ms is more than max allowed ${r} ms.`;throw console.error(e),new Error(e)}return console.log(`ET ${g} ms is OK.`),g}(r)}function i(e){e.callSync();const t=e.getOutputParamValue(),n=e.inputs.col;return t&&(n.semType=t),n}(0,t.gM)((async()=>{const t=e.Func.find({package:"Bio",name:"detectMacromolecule"});n=t[0];const r=e.Column.fromStrings("seq",["ACGT","ACGT","ACGT"]);await n.prepare({col:r}).call()})),(0,t.t6)("fastaDnaShorts50Few50",(async()=>{await r(10,l.Hi.FASTA,l.YI.DNA,50,50)})),(0,t.t6)("fastaDnaShorts50Many1E6",(async()=>{await r(20,l.Hi.FASTA,l.YI.DNA,50,1e6)})),(0,t.t6)("fastaDnaLong1e6Few50",(async()=>{await r(20,l.Hi.FASTA,l.YI.DNA,1e6,50)})),(0,t.t6)("separatorDnaShorts50Few50",(async()=>{await r(10,l.Hi.SEPARATOR,l.YI.DNA,50,50,"/")})),(0,t.t6)("separatorDnaShorts50Many1E6",(async()=>{await r(20,l.Hi.SEPARATOR,l.YI.DNA,50,1e6,"/")})),(0,t.t6)("separatorDnaLong1e6Few50",(async()=>{await r(20,l.Hi.SEPARATOR,l.YI.DNA,1e6,50,"/")}))}));var y=n(608),w=n(1619),b=n(6740);async function v(n,r){const i=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(i);const s=e.DataFrame.fromCsv(r),o=i.getCol("seq");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const c=s.getCol("seq"),l=await(0,y.eE)(o,!0);(0,t.J6)(l.toList(),c.toList())}async function A(n,r,i,s,o,c){const u=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(u);const d=e.DataFrame.fromCsv(r).getCol("seq"),h=u.getCol("seq");(0,t.E3)(h.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(h.meta.units,i),o&&(0,t.E3)(h.getTag(l.gp.alphabet),o);const p=await(0,w.D)({col:h,pepsea:{method:c}});(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,s),(0,t.E3)(p.getTag(l.gp.aligned),"SEQ.MSA"),o&&(0,t.E3)(p.getTag(l.gp.alphabet),o),(0,t.J6)(p.toList(),d.toList())}(0,t.L1)("MSA",(async()=>{(0,t.t6)("isCorrect",(async()=>{await v("seq\nFWRWYVKHP\nYNRWYVKHP\nMWRSWYCKHP","seq\nFWR-WYVKHP\nYNR-WYVKHP\nMWRSWYCKHP")})),(0,t.t6)("isCorrectLong",(async()=>{await v("seq\nFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP","seq\nFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHP\nYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP")})),(0,t.t6)("isCorrectHelm",(async()=>{await(0,b.m8)(),await A("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2}$$$$\n PEPTIDE1{meI.Aca.N.T.dE.Thr_PO3H2}$$$$\n PEPTIDE1{hHis.Aca.N.T.dE.Thr_PO3H2}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2\n .meI.Aca.N.T.dE.Thr_PO3H2\n .hHis.Aca.N.T.dE.Thr_PO3H2",l.Hi.HELM,l.Hi.SEPARATOR,void 0,"mafft")}),{timeout:6e4}),(0,t.t6)("isCorrectHelmLong",(async()=>{await(0,b.m8)(),await A("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2}$$$$\n PEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\n PEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2\n meI.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me.\n Lys_Boc.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me.",l.Hi.HELM,l.Hi.SEPARATOR,void 0,"mafft")}),{timeout:6e4}),(0,t.t6)("isCorrectSeparator",(async()=>{await A("seq\n F-W-P-H-E-Y\n Y-N-R-Q-W-Y-V\n M-K-P-S-E-Y-V","seq\n FWPHEY-\n YNRQWYV\n MKPSEYV",l.Hi.SEPARATOR,l.Hi.FASTA,l.YI.PT)})),(0,t.t6)("isCorrectSeparatorLong",(async()=>{await A("seq\n M-I-E-V-F-L-F-G-I-V-L-G-L-I-P-I-T-L-A-G-L-F-V-T-A-Y-L-Q-Y-R-R-G-D-Q-L-D-L\n M-M-E-L-V-L-K-T-I-I-G-P-I-V-V-G-V-V-L-R-I-V-D-K-W-L-N-K-D-K\n M-D-R-T-D-E-V-S-N-H-T-H-D-K-P-T-L-T-W-F-E-E-I-F-E-E-Y-H-S-P-F-H-N","seq\n MIEV-FLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n MMEL-VLKTII-GPIVVGVVLRIVDKWLNKDK------\n MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN-----",l.Hi.SEPARATOR,l.Hi.FASTA,l.YI.PT)}))}));var E=n(1991),C=n.n(E),T=n(5785),S=n(6642);async function _(t){const n=await async function(e){return await _e.files.readAsText(e)}(t),r=e.DataFrame.fromCsv(n);return r.name=t.replace(".csv",""),r}async function x(e,n=5e3){await(0,t.cb)(0),await(0,t.PE)(e.onAfterDrawContent,(()=>{}),(()=>{e.invalidate()}),n);const r=e.columns.length;for(let t=0;t<r;++t){const n=e.columns.byIndex(t);if(n){const t=e.cell(n.name,0),[r,o,a]=(0,S.h)(t),c=(void 0,(s=i=a.rendererBack)&&void 0!==s.onRendered&&void 0!==s.invalidate&&void 0!==s.awaitRendered?i:null);c&&await c.awaitRendered()}}var i,s}var P=n(4139),M=n(9322);async function $(e,n){const r=(0,l.J9)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(r)} .`),(0,t.J6)(C()(r.originals).toArray(),n)}async function N(e,n){const r=(0,M.qp)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(r)} .`),(0,t.J6)(C()(r.originals).toArray(),n)}(0,t.L1)("splitters",(async()=>{(0,t.gM)((async()=>{})),(0,t.Pl)((async()=>{}));const n=["M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",["M","MeI","Y","K","E","T","L","L","MeF","P","K","T","D","F","P","M","R","G","G","L","MeA"]],r=["[meI][Pip][dK][Thr_PO3H2][L-hArg(Et,Et)][D-Tyr_Et][Tyr_ab-dehydroMe][dV]EN[D-Orn][D-aThr][Phe_4Me]",["meI","Pip","dK","Thr_PO3H2","L-hArg(Et,Et)","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],i=["PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],s=["PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.D-Dap.dV.E.N.pnG.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],o=["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[D-Dap].[dV].E.N.[pnG].[Phe_4Me]}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],u=["RNA1{R(U)P.R(T)P.R(G)P.R(C)P.R(A)}$$$$",["R(U)P","R(T)P","R(G)P","R(C)P","R(A)"]],d=["RNA1{P.R(U)P.R(T)}$$$$",["P","R(U)P","R(T)"]],h=["RNA1{P.R(U).P.R(T)}$$$$",["P","R(U)","P","R(T)"]];(0,t.t6)("fastaMulti",(async()=>{await $(n[0],n[1])})),(0,t.t6)("fastaFromHelm",(async()=>{await $(r[0],r[1])})),(0,t.t6)("helm1",(async()=>{await N(i[0],i[1])})),(0,t.t6)("helm2",(async()=>{await N(s[0],s[1])})),(0,t.t6)("helm3-multichar",(async()=>{await N(o[0],o[1])})),(0,t.t6)("testHelm1",(async()=>{await N(u[0],u[1])})),(0,t.t6)("testHelm2",(async()=>{await N(d[0],d[1])})),(0,t.t6)("testHelm3",(async()=>{await N(h[0],h[1])})),(0,t.t6)("splitToMonomers",(async()=>{const e=await a.dapi.files.readCsv("System:AppData/Bio/samples/MSA.csv"),n=e.getCol("MSA"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r),n.setTag(l.gp.aligned,P.gN);const i=await(0,T.k)(e,n);(0,t.E3)(i.columns.names().includes("17"),!0),await a.data.detectSemanticTypes(i);const s=a.shell.addTableView(i);await x(s.grid),(0,t.E3)(s.grid.dataFrame.id,e.id)})),(0,t.t6)("getHelmMonomers",(async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await a.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],r=t.getCol("HELM"),i=(0,c.getHelmMonomers)(r),s=n.filter((e=>!i.includes(e))),o=i.filter((e=>!n.includes(e)));if(s.length>0||o.length){const e=[];throw s.length>0&&e.push(`Missed monomers ${JSON.stringify(s)}.`),o.length>0&&e.push(`Unexpected monomers ${JSON.stringify(o)}.`),new Error(e.join(" "))}}))}));var L=n(6718),I=n(4356);const R={PEPTIDE:324,RNA:383,CHEM:0};(0,t.L1)("monomerLibraries",(()=>{let e,n=null;(0,t.gM)((async()=>{e=await(0,L.pj)(),n=(0,I.ub)()})),(0,t.Pl)((async()=>{await(0,I.Eu)(n)})),(0,t.t6)("default",(async()=>{await(0,I.Eu)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadLibraries(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await(0,I.yZ)(),await e.loadMonomerLib(!0),function(e){const n=R,r=e.getSummaryObj();for(const e in n)n[e]||delete n[e];for(const e in r)r[e]||delete r[e];if(0==Object.keys(n).length&&0!=Object.keys(r).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(n).length&&0==Object.keys(r).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(r,n),(0,t.Xk)(n,r)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(n)} does not match actual ${JSON.stringify(r)}.`)}}(e.getMonomerLib())})),(0,t.t6)("empty",(async()=>{const n=await(0,I.ub)(),r=await e.getFileManager();let i=r.getValidLibraryPaths();0===i.length&&(i=await r.getValidLibraryPathsAsynchronously()),n.exclude=i,n.explicit=[],await(0,I.Eu)(n),await e.loadMonomerLib(!0);const s=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===s.length,!0)}))}));var O=n(7389),k=n(1757),G=n.n(k),H=n(1858),D=n(6873),F=n(5433);async function U(n,r){const i=n(),s=e.DataFrame.fromColumns(i);await a.data.detectSemanticTypes(s);const o=Date.now(),c=(s.columns.byName("MSA"),a.shell.addTableView(s));await x(c.grid),(0,t.E3)(c.grid.dataFrame.id,s.id);const l=Date.now()-o;console.log(`Performance test: ${r}: ${l}ms`)}(0,t.L1)("renderers",(()=>{(0,t.t6)("long sequence performance ",(async()=>{await U(D.dW,"Long sequences")})),(0,t.t6)("many sequence performance",(async()=>{await U(D.fD,"Many sequences")})),(0,t.t6)("rendererMacromoleculeFasta",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("Sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await x(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await x(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await x(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,P.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),r=(0,c.importFasta)(n)[0],i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),console.log("Bio: tests/renderers/afterMsa, table view"),await x(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${i.semType}", units="${i.meta.units}", cell.renderer="${i.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(i.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(i.meta.units,l.Hi.FASTA),(0,t.E3)(i.getTag(l.gp.aligned),"SEQ"),(0,t.E3)(i.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"sequence");const d=await(0,w.D)({col:i});await x(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),(0,t.E3)(d.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(d.meta.units,l.Hi.FASTA),(0,t.E3)(d.getTag(l.gp.aligned),"SEQ.MSA"),(0,t.E3)(d.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(d.getTag(e.TAGS.CELL_RENDERER),"sequence"),u.GO.forColumn(d)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const c=await(0,F.r)(i,l.Hi.SEPARATOR,"/");await x(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const d=c.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),u.GO.forColumn(c)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const n=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),r=a.shell.addTableView(n);await x(r.grid);const i=n.getCol("sequence"),s=u.GO.forColumn(i).convert(l.Hi.HELM);n.columns.add(s),await x(r.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=P.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const i=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==i)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${i}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const r=e.DataFrame.fromCsv(n);r.currentRowIdx=0;const i=a.shell.addTableView(r),s=r.plot.scatter({x:"x",y:"y"});i.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),x(i.grid,500)]);const o=s.root.getBoundingClientRect(),c=s.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:o.left+c.x,clientY:o.top+c.y}),u=G()(s.root).find("canvas").get()[0];await(0,t.PE)((0,H.fromEvent)(u,"mousemove"),(()=>{_e.logger.debug(`Test: event, currentRowIdx=${r.currentRowIdx}`),(0,t.E3)(G()(O.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await x(i.grid,500)}()}));const n="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var V=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.awaitLoaded(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const i={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(i))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),i=new V.J(null,n,_e.logger,3,(()=>({seqHandler:u.GO.forColumn(n),monomerCharWidth:7,separatorWidth:12,monomerToShort:l.zS}))),s=r.testList;for(let e=0;e<n.length;++e)i.getCellMonomerLengths(e,1e4);const o=[];for(const[e,t]of C().enumerate(s)){const t={pos:i.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", \n"))}))})),(0,t.L1)("renderers: monomerPlacer",(()=>{const e=[10,20,30,40,50,60],n={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[r,i]of Object.entries(n))(0,t.t6)("hitBounds-"+r,(async()=>{const n=(0,V.B)(e,i.x);(0,t.E3)(n,i.tgt)}))})),(0,t.L1)("converters",(()=>{let n;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(n||(n={}));const r={[n.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[n.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[n.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[n.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[n.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[n.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[n.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[n.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[n.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[n.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[n.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[n.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[n.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[n.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[n.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[n.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[n.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[n.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},i=new Set(Object.values(l.gp));async function s(t){const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i}function o(e,n){if(e===l.Hi.SEPARATOR&&!n)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(r){const i=u.GO.forColumn(r).convert(e,n);return(0,t.E3)(i.meta.units,e),i}}async function c(e,n,r){const o=(await s(e)).getCol("seq"),a=n(o),c=(await s(r)).getCol("seq");(0,t.J6)(a.toList(),c.toList());const d=u.GO.forColumn(o),h=u.GO.forColumn(a);for(const[e,n]of Object.entries(c.tags)){if(!i.has(e)||d.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e)||h.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e))continue;const r=a.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await c(n.fastaPt,o(l.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testFastaDnaToSeparator",(async()=>{await c(n.fastaDna,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testFastaRnaToSeparator",(async()=>{await c(n.fastaRna,o(l.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testFastaGapsToSeparator",(async()=>{await c(n.fastaGaps,o(l.Hi.SEPARATOR,"/"),n.separatorGaps)})),(0,t.t6)("testFastaUnToSeparator",(async()=>{await c(n.fastaUn,o(l.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testFastaPtToHelm",(async()=>{await c(n.fastaPt,o(l.Hi.HELM),n.helmPt)})),(0,t.t6)("testFastaDnaToHelm",(async()=>{await c(n.fastaDna,o(l.Hi.HELM),n.helmDna)})),(0,t.t6)("testFastaRnaToHelm",(async()=>{await c(n.fastaRna,o(l.Hi.HELM),n.helmRna)})),(0,t.t6)("testFastaGapsToHelm",(async()=>{await c(n.fastaGaps,o(l.Hi.HELM),n.helmGaps)})),(0,t.t6)("testSeparatorPtToFasta",(async()=>{await c(n.separatorPt,o(l.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testSeparatorDnaToFasta",(async()=>{await c(n.separatorDna,o(l.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testSeparatorRnaToFasta",(async()=>{await c(n.separatorRna,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testSeparatorGapsToFasta",(async()=>{await c(n.separatorGaps,o(l.Hi.FASTA),n.fastaGaps)})),(0,t.t6)("testSeparatorUnToFasta",(async()=>{await c(n.separatorUn,o(l.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testSeparatorPtToHelm",(async()=>{await c(n.separatorPt,o(l.Hi.HELM),n.helmPt)})),(0,t.t6)("testSeparatorDnaToHelm",(async()=>{await c(n.separatorDna,o(l.Hi.HELM),n.helmDna)})),(0,t.t6)("testSeparatorRnaToHelm",(async()=>{await c(n.separatorRna,o(l.Hi.HELM),n.helmRna)})),(0,t.t6)("testSeparatorGapsToHelm",(async()=>{await c(n.separatorGaps,o(l.Hi.HELM),n.helmGaps)})),(0,t.t6)("testHelmDnaToFasta",(async()=>{await c(n.helmDna,o(l.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testHelmRnaToFasta",(async()=>{await c(n.helmRna,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmPtToFasta",(async()=>{await c(n.helmPt,o(l.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testHelmUnToFasta",(async()=>{await c(n.helmUn,o(l.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testHelmDnaToSeparator",(async()=>{await c(n.helmDna,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmRnaToSeparator",(async()=>{await c(n.helmRna,o(l.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testHelmPtToSeparator",(async()=>{await c(n.helmPt,o(l.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testHelmUnToSeparator",(async()=>{await c(n.helmUn,o(l.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testHelmLoneRibose",(async()=>{await c(n.helmLoneRibose,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmLoneDeoxyribose",(async()=>{await c(n.helmLoneDeoxyribose,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmLonePhosphorus",(async()=>{await c(n.helmLonePhosphorus,o(l.Hi.FASTA),n.fastaRna)}))}));var Y=n(3516);(0,t.L1)("fastaFileHandler",(()=>{const n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function i(e){const i=new Y.m(e),s=i.descriptionsArray,o=i.sequencesArray;(0,t.J6)([s,o],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{i(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{i(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n ")})),(0,t.t6)("testExtraNewlines",(async()=>{i(">description:1\n\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVF\nLFGIVLGLI\nPITLAGLFVTA\nYLQYRRGDQLDL\n\n>description:3\nM\nME\n\nLVLKTIIG\n\nPIVVGVVLRI\nVDKWLNKDK\n\n\n>description:4\n\nMDRT\n\nDEVSNHTHDKP\n\nTLTWFEEIFEE\n\n\n\nYHSPFHN\n")}))}));var B=n(3890);(0,t.L1)("fastaExport",(()=>{let n;!function(e){e.single="single",e.multi="multi"}(n||(n={}));const r={[n.single]:{src:"MDYKETLLMPKTDFPMRGGLP",tgt:["MDYKETLLMP","KTDFPMRGGL","P"]},[n.multi]:{src:"M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",tgt:["M[MeI]YKETLL[MeF]P","KTDFPMRGGL","[MeA]"]}};let i;!function(e){e.test1="test1",e.test2="test2"}(i||(i={}));const s={[i.test1]:{srcCsv:"id,seq\n1,MDYKETLLMP\n2,KTDFPMRGGL\n3,P",idCols:["id"],seqCol:"seq",lineWidth:10,tgtFasta:">1\nMDYKETLLMP\n>2\nKTDFPMRGGL\n>3\nP\n"},[i.test2]:{srcCsv:"id,id2,seq\n1,seqA,M[MeI]YKETLL[MeF]P\n2,seqB,KTDFPMRGGL\n3,seqC,[MeA]\n",idCols:["id2","id"],seqCol:"seq",lineWidth:5,tgtFasta:">seqA|1\nM[MeI]YKE\nTLL[MeF]P\n>seqB|2\nKTDFP\nMRGGL\n>seqC|3\n[MeA]\n"}};function o(n,i=10){const s=r[n].src,o=e.Column.fromStrings("src",[s]);o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=l.Hi.FASTA;const a=u.GO.forColumn(o).getSplitted(0),c=(0,B.aS)(a,i),d=r[n].tgt;(0,t.J6)(c,d)}async function a(n){const r=e.DataFrame.fromCsv(n.srcCsv),i=r.getCol(n.seqCol);i.semType=e.SEMTYPE.MACROMOLECULE,i.meta.units=l.Hi.FASTA;const s=n.idCols.map((e=>r.getCol(e))),o=(0,B.wz)(s,i,n.lineWidth);(0,t.E3)(o,n.tgtFasta)}(0,t.t6)("wrapSequenceSingle",(async()=>{o(n.single,10)})),(0,t.t6)("wrapSequenceMulti",(async()=>{o(n.multi,10)})),(0,t.t6)("saveAsFastaTest1",(async()=>{a(s[i.test1])})),(0,t.t6)("saveAsFastaTest2",(async()=>{a(s[i.test2])}))}));var W=n(4152),j=n(2738);const K=j._S;(0,t.L1)("bio",(()=>{const n="seq\nACGTCT\nCAGTGT\nTTCAAC";(0,t.t6)("testGetStatsHelm1",(async()=>{const n=e.DataFrame.fromCsv("seq\nPEPTIDE1{meI}$$$$").getCol("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.HELM;const r=(0,M.vZ)(n,1,l.qp);(0,t.Xk)(r.freq,{meI:1}),(0,t.E3)(r.sameLength,!0)})),(0,t.t6)("testGetStatsN1",(async()=>{await async function(n){const r=e.DataFrame.fromCsv(n).col("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA;const i=(0,M.vZ)(r,5,l.J9);(0,t.Xk)(i.freq,{A:4,C:5,G:3,T:6}),(0,t.E3)(i.sameLength,!0)}(n)})),(0,t.t6)("testGetAlphabetSimilarity",(async()=>{await async function(){const e={A:2041,C:3015,G:3015,T:2048,[K]:1e3},n=new Set(Object.keys(o.Q.Names)),r=(0,l.nq)(e,n);(0,t.E3)(r>.6,!0)}()})),(0,t.t6)("testPickupPaletteN1",(async()=>{await async function(n){const r=e.DataFrame.fromCsv(n).col("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA;const i=(0,l.SM)(r);(0,t.E3)(i instanceof o.A,!0)}(n)})),(0,t.t6)("testPickupPaletteN1e",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nACGTAT\nCAGTTG\nTTCG2C").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof o.A,!0)}()})),(0,t.t6)("testPickupPaletteAA1",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nFWPHEYV\nYNRQWYV\nMKPSEYV").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof i.X,!0)}()})),(0,t.t6)("testPickupPaletteX",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nXZJ{}2\n5Z4733\n3Z6></\n675687").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof W.$u,!0)}()}))})),(0,t.L1)("WebLogo.monomerToShort",(()=>{(0,t.t6)("longMonomerSingle",(async()=>{(0,t.E3)((0,l.zS)("S",5),"S")})),(0,t.t6)("longMonomerShort",(async()=>{(0,t.E3)((0,l.zS)("Short",5),"Short")})),(0,t.t6)("longMonomerLong56",(async()=>{(0,t.E3)((0,l.zS)("Long56",6),"Long56")})),(0,t.t6)("longMonomerComplexFirstPartShort",(async()=>{(0,t.E3)((0,l.zS)("Long-long",5),"Long…")})),(0,t.t6)("longMonomerComplexFirstPartLong56",(async()=>{(0,t.E3)((0,l.zS)("Long56-long",6),"Long5…")})),(0,t.t6)("monomerToShort",(async()=>{const e=[["AbC","AbC"],["AbCd","Ab…"],["ABc","ABc"],["ABcd","AB…"],["A_b","A_b"],["A_bc","A…"],["Ab_c","Ab…"],["A1_b","A1…"],["Abc_d","Ab…"],["Abcd_e","Ab…"],["A-b","A-b"],["A-bc","A…"],["Ab-c","Ab…"],["A1-b","A1…"],["Abc-d","Ab…"],["Abcd-e","Ab…"],["A","A"],["Ab","Ab"],["Abc","Abc"],["Ab…","Ab…"],["Abcd","Ab…"],["Abcde","Ab…"]],n=e.map((e=>e[0])),r=e.map((e=>e[1])),i=n.map((e=>(0,l.zS)(e,3)));(0,t.J6)(i,r)}))}));var q=n(8047);const z=j._S;function Z(e,n){(0,t.E3)(e.name,n.name),(0,t.J6)(e.getMonomers(),n.getMonomers());for(const r of e.getMonomers())(0,t.E3)(e.getFreq(r).rowCount,n.getFreq(r).rowCount)}(0,t.L1)("WebLogo-positions",(()=>{const n="seq\nATC-G-TTGC--\nATC-G-TTGC--\n-TC-G-TTGC--\n-TC-GCTTGC--\n-TC-GCTTGC--";(0,t.t6)("allPositions",(async()=>{const r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.DNA),s.setTag(l.gp.aligned,"SEQ.MSA");const o=await r.plot.fromType("WebLogo");await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,u=[new q.Ue(0,"1",{A:new q.Tc(2),[z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(5)}),new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(3,"4",{[z]:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)}),new q.Ue(7,"8",{T:new q.Tc(5)}),new q.Ue(8,"9",{G:new q.Tc(5)}),new q.Ue(9,"10",{C:new q.Tc(5)}),new q.Ue(10,"11",{[z]:new q.Tc(5)}),new q.Ue(11,"12",{[z]:new q.Tc(5)})];(0,t.E3)(c.length,u.length);for(let e=0;e<c.length;e++){(0,t.E3)(c[e].name,u[e].name);for(const n of c[e].getMonomers())(0,t.E3)(c[e].getFreq(n).rowCount,u[e].getFreq(n).rowCount)}await o.awaitRendered()})),(0,t.t6)("positions with shrinkEmptyTail option true (filtered)",(async()=>{const n=e.DataFrame.fromCsv("seq\n-TC-G-TTGC--\n-TC-GCTTGC--\n-T--C-GT-\n-T--C-GT-\n-T--C-GT-\n-T--CCGT-"),r=a.shell.addTableView(n),i=n.getCol("seq");i.semType=e.SEMTYPE.MACROMOLECULE,i.meta.units=l.Hi.FASTA,i.setTag(l.gp.alphabet,l.YI.DNA),i.setTag(l.gp.aligned,"SEQ"),n.filter.init((e=>e>2)),n.filter.fireChanged();const s=await n.plot.fromType("WebLogo",{shrinkEmptyTail:!0});await(0,t.PE)(s.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(s.root,e.DOCK_TYPE.DOWN)}),500);const o=s.positions,c=[new q.Ue(0,"1",{[z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(3)}),new q.Ue(2,"3",{[z]:new q.Tc(3)}),new q.Ue(3,"4",{[z]:new q.Tc(3)}),new q.Ue(4,"5",{C:new q.Tc(3)}),new q.Ue(5,"6",{[z]:new q.Tc(2),C:new q.Tc(1)}),new q.Ue(6,"7",{G:new q.Tc(3)}),new q.Ue(7,"8",{T:new q.Tc(3)}),new q.Ue(8,"9",{[z]:new q.Tc(3)})];(0,t.E3)(o.length,c.length);for(let e=0;e<o.length;e++){(0,t.E3)(o[e].name,c[e].name);for(const n of o[e].getMonomers())(0,t.E3)(o[e].getFreq(n).rowCount,c[e].getFreq(n).rowCount)}await s.awaitRendered()})),(0,t.t6)("positions with skipEmptyPositions option",(async()=>{const r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.DNA),s.setTag(l.gp.aligned,"SEQ.MSA");const o=await r.plot.fromType("WebLogo",{skipEmptyPositions:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,u=[new q.Ue(0,"1",{A:new q.Tc(2),[z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(5)}),new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)}),new q.Ue(7,"8",{T:new q.Tc(5)}),new q.Ue(8,"9",{G:new q.Tc(5)}),new q.Ue(9,"10",{C:new q.Tc(5)})];(0,t.E3)(c.length,u.length);for(let e=0;e<c.length;e++)Z(c[e],u[e]);await o.awaitRendered()})),(0,t.t6)("count sequences for monomer at position",(async()=>{const r=function(t,n,r){const i=e.DataFrame.fromCsv(t),s=i.getCol("seq");return s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=n,s.setTag(l.gp.alphabet,r),s.setTag(l.gp.aligned,"SEQ.MSA"),i}(n,l.Hi.FASTA,l.YI.DNA),i=r.getCol("seq"),s=a.shell.addTableView(r),o=await r.plot.fromType("WebLogo",{startPositionName:"3",endPositionName:"7",skipEmptyPositions:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{s.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,d=[new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)})];(0,t.E3)(c.length,d.length);for(let e=0;e<c.length;e++)Z(c[e],d[e]);const h=c[1],p=u.GO.forColumn(i),m=(0,q.eN)(r,p,r.filter,"G",h);(0,t.E3)(m,5),await o.awaitRendered()})),(0,t.t6)("empty",(async()=>{const n=e.DataFrame.fromColumns([(()=>{const t=e.Column.fromStrings("seq",[]);return t.semType=e.SEMTYPE.MACROMOLECULE,t.meta.units=l.Hi.FASTA,t.setTag(l.gp.alphabet,l.YI.DNA),t})()]),r=a.shell.addTableView(n),i=await n.plot.fromType("WebLogo");await(0,t.PE)(i.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(i.root,e.DOCK_TYPE.DOWN)}),500),i.positions,await i.awaitRendered()}))})),(0,t.L1)("WebLogo-project",(()=>{(0,t.t6)("fasta",(async()=>{const n="Tests.Bio.WebLogo-project.fasta",r=await _e.files.readCsv("tests/filter_FASTA.csv"),i=r.name,s=r.getCol("fasta");await a.data.detectSemanticTypes(r);const o=a.shell.addTableView(r),c=await r.plot.fromType("WebLogo",{sequenceColumnName:s.name});o.dockManager.dock(c),await c.awaitRendered(),await x(o.grid),await async function(t,n,r,i){const s=e.Project.create(),o=r.saveLayout();s.name=t,s.addChild(n),s.addChild(o),await a.dapi.layouts.save(r.saveLayout()),await a.dapi.tables.uploadDataFrame(i),await a.dapi.tables.save(n),await a.dapi.projects.save(s)}(n,r.getTableInfo(),o,r),a.shell.closeAll(),await(0,t.cb)(500),await a.dapi.projects.open(n);const l=a.shell.getTableView(i),u=C()(l.viewers).toArray();(0,t.E3)(u.length,2),(0,t.E3)(u.filter((e=>"Grid"===e.type)).length,1);const d=u.find((e=>"WebLogo"===e.type));(0,t.E3)(!!d,!0),await x(o.grid),await d.awaitRendered()}),{skipReason:"depends on 1.18"})})),(0,t.L1)("WebLogo-layout",(()=>{(0,t.t6)("fasta",(async()=>{const e=await _e.files.readCsv("tests/filter_FASTA.csv"),n=e.getCol("fasta");await a.data.detectSemanticTypes(e);const r=a.shell.addTableView(e),i=await e.plot.fromType("WebLogo",{sequenceColumnName:n.name});r.dockManager.dock(i),await(0,t.cb)(2*q.VN.render),await i.awaitRendered(),await x(r.grid);const s=r.saveLayout();s.toJson(),r.loadLayout(s),await(0,t.cb)(2*q.VN.render),await i.awaitRendered(),await x(r.grid);const o=C()(r.viewers).toArray();(0,t.E3)(o.length,2),(0,t.E3)(o.filter((e=>"Grid"===e.type)).length,1),(0,t.E3)(o.filter((e=>"WebLogo"===e.type)).length,1)}))}));var X=n(966);function J(e,t){let n=null;for(const r of e.viewers)r.type===t&&(n=r);return n}(0,t.L1)("checkInputColumn",(()=>{const n="seq\nseq1,\nseq2,\nseq3,\nseq4";(0,t.t6)("testMsaPos",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA,r.setTag(l.gp.alphabet,l.YI.DNA),r.setTag(l.gp.aligned,"SEQ");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!0)})),(0,t.t6)("testMsaNegHelm",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.HELM,r.setTag(l.gp.alphabetIsMultichar,"true");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!1)})),(0,t.t6)("testMsaNegUN",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA,r.setTag(l.gp.alphabet,"UN"),r.setTag(l.gp.alphabetSize,"11"),r.setTag(l.gp.alphabetIsMultichar,"true"),r.setTag(l.gp.aligned,"SEQ");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!1)})),(0,t.t6)("testGetActionFunctionMeta",(async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find((e=>"sequence"==e.name))}))})),(0,t.L1)("similarity/diversity",(async()=>{(0,t.t6)("similaritySearchViewer",(async()=>{await async function(){const n=await _e.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(r);const i=a.shell.addTableView(r),s=i.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const o=await i.dataFrame.plot.fromType("Sequence Similarity Search");let c=!1;if(o.computeCompleted.subscribe((e=>{e&&(c=!0)})),i.dockManager.dock(o,e.DOCK_TYPE.RIGHT,null,"Similarity"),await o.renderPromise,await(0,t.bk)((()=>void 0!==J(i,"Sequence Similarity Search")),"Sequence Similarity Search viewer has not been created",100),!o.initialized)throw new Error("The viewer is not initialized.");if(!o.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!o.beforeRender())throw new Error("The viewer is not able to render.");if(!o.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=o;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Similarity Search viewer grid has not been created",100);(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.scores.get(0),e.FLOAT_NULL),(0,t.E3)(l.idxs.get(0),0),(0,t.E3)(l.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(l.scores.get(1).toFixed(2),"0.73"),(0,t.E3)(l.idxs.get(1),4),(0,t.E3)(l.molCol.get(1),"Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"),i.dataFrame.currentRowIdx=1,await(0,t.bk)((()=>1===l.targetMoleculeIdx),"Target molecule has not been changed",5e3),await(0,t.bk)((()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===l.molCol.get(0)),"Incorrect first similar molecule",5e3)}()})),(0,t.t6)("diversitySearchViewer",(async()=>{await async function(){const n=await _e.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const s=i.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const o=await i.dataFrame.plot.fromType("Sequence Diversity Search");let c=!1;if(o.computeCompleted.subscribe((e=>{e&&(c=!0)})),i.dockManager.dock(o,e.DOCK_TYPE.DOWN,null,"Diversity"),await o.renderPromise,await(0,t.bk)((()=>void 0!==J(i,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!o.initialized)throw new Error("The viewer is not initialized.");if(!o.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!o.beforeRender())throw new Error("The viewer is not able to render.");if(!o.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=o;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.initialized,!0),(0,t.E3)(l.renderMolIds.length>0,!0)}()}))}));var Q=n(9124),ee=n(1687),te=n(4577);async function ne(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const n=new ee._i;return n.attach(t),n.applyState({columnName:e}),n.column=t.col(e),n.columnName=e,n}(0,t.L1)("bio-substructure-filters",(async()=>{let n,r,i;(0,t.gM)((async()=>{n=await(0,Q.b)(),r=await(0,L.pj)(),i=await(0,I.ub)(),await(0,I.yZ)(),await r.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("fasta",(async()=>{const e=await _("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=new ee._i;n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new te.n("MD")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,3),(0,t.E3)(n.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("separator",(async()=>{const e=await _("tests/filter_MSA.csv"),n=new ee._i;await a.data.detectSemanticTypes(e),n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"SeparatorBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("/meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI-hHis","-")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1)}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("helm-dialog",(async()=>{const e="Bio tests: substructureFilters/helm-dialog",n=await _("tests/filter_HELM.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n);_e.logger.debug(`${e}, filter attaching.`);const i=new ee._i;i.attach(n);const s=O.dialog("Test filters").add(i.root).show();await i.awaitRendered();try{const s=i.bioFilter;(0,t.E3)(null!==i.bioFilter,!0,"bioFilter is not created"),_e.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{A.C}$$$$V2.0")}),2e4),_e.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,1),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"0001"),_e.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{C}$$$$V2.0")}),2e4),await x(r.grid),_e.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,2),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"1001")}finally{s.close()}await i.awaitRendered(),await(0,t.cb)(3e3)})),(0,t.t6)("helm-view",(async()=>{const e=await _("tests/filter_HELM.csv");e.getCol("HELM string"),await a.data.detectSemanticTypes(e);const t=a.shell.addTableView(e);t.getFiltersGroup(),await x(t.grid)})),(0,t.t6)("sync-fasta",(async()=>{const e=await _e.files.readCsv("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=await ne("fasta",e),r=await ne("fasta",e);await Promise.all([n.awaitRendered(),r.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const i=n.bioFilter,s=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{i.props=new te.n("MD")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(s.props.substructure,"MD")}finally{n.detach(),r.detach()}await Promise.all([n.awaitRendered(),r.awaitRendered()])})),(0,t.t6)("sync-msa",(async()=>{const e=await _e.files.readCsv("tests/filter_MSA.csv");await a.data.detectSemanticTypes(e);const n="hHis-Aca",r=await ne("MSA",e),i=await ne("MSA",e);await Promise.all([r.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter");const s=r.bioFilter,o=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{s.props=new ee.AR(n,"-")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(o.props.substructure,n),(0,t.E3)(o.props.separator,"-")}finally{r.detach(),i.detach()}await Promise.all([r.awaitRendered(),i.awaitRendered()])})),(0,t.t6)("sync-helm",(async()=>{const e=await _e.files.readCsv("tests/filter_HELM.csv");await a.data.detectSemanticTypes(e);const n=a.shell.addTableView(e),r="PEPTIDE1{A.C}$$$$V2.0",i=await ne("HELM string",e),s=await ne("HELM string",e),o=O.dialog("Test filters").add(i.root).add(s.root).show();await Promise.all([i.awaitRendered(),s.awaitRendered()]);try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"HelmBioFilter"),(0,t.E3)(s.bioFilter.type,"HelmBioFilter");const o=i.bioFilter,a=s.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(r)}),6e4,"await onRowsFiltered"),await x(n.grid),_e.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*i.debounceTime),_e.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,1),await i.awaitRendered(),(0,t.E3)(a.props.substructure,r)}finally{i.detach(),s.detach(),o.close()}await Promise.all([i.awaitRendered(),s.awaitRendered()]),await x(n.grid),await(0,t.cb)(3e3)})),(0,t.t6)("two-columns-fasta",(async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="seq1",s="CGGCTG",o=n.getCol("trueSeq1").toList(),c="seq2",l="GCATT",u=n.getCol("trueSeq2").toList(),d=[{type:"Bio:bioSubstructureFilter",columnName:i},{type:"Bio:bioSubstructureFilter",columnName:c}],h=await n.plot.fromType(e.VIEWER.FILTERS,{filters:d});r.dockManager.dock(h,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await x(r.grid);const p=h.filters[0],m=h.filters[1];(0,t.E3)(p.column.name,i),(0,t.E3)(m.column.name,c);const f=p.bioFilter,g=m.bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n(s)}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n("")}),1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,o.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),o.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n(l)}),1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),u.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n("")}),1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n(s)}),5e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n(l)}),5e3,"testEvent onRowsFiltered on both");const y=C().count(0).take(n.rowCount).map((e=>o[e]*u[e])).toArray();(0,t.E3)(n.filter.trueCount,y.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),y.map((e=>e.toString())).join("")),await Promise.all([p.awaitRendered(),m.awaitRendered(),x(r.grid)])})),(0,t.t6)("reset-fasta",(async()=>{const n=await _("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="MD",s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});r.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await x(r.grid);const o=s.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(i)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(o.props.substructure,i),(0,t.E3)(o.substructureInput.value,i),G()(s.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await x(r.grid),(0,t.E3)(o.props.substructure,""),(0,t.E3)(o.substructureInput.value,"")})),(0,t.t6)("reopen",(async()=>{const n=await _e.files.readCsv("tests/filter_FASTA.csv"),r=a.shell.addTableView(n),i=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:i});r.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await x(r.grid),s.close(),await x(r.grid);const o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:i});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await x(r.grid)}))}));var re=n(8152);class ie{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var se=n(9192);(0,t.L1)("PepSeA",(()=>{(0,t.gM)((async()=>{await(0,b.m8)()})),(0,t.t6)("Basic alignment",(async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,re.GD)(n.getCol("HELM"),"msa(HELM)"),i=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==i.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new ie,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),i=await(0,re.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),s=r.getCol("MSA");(0,t.J6)(i.toList(),s.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")}),{timeout:6e4,stressTest:!0}),(0,t.t6)("error",(async()=>{const n=new ie;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,re.GD)(t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,r]=(0,se.AP)(e);n.error(t,void 0,r)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")}))})),(0,t.L1)("viewers",(()=>{const n=e.Func.find({package:"Bio",tags:["viewer"]}).map((e=>e.friendlyName));for(const e of n)(0,t.t6)(e,(async()=>{const n=await _("samples/FASTA_DNA.csv");await(0,t.Bl)(e,n,{detectSemanticTypes:!0})}),{skipReason:{"Sequence Similarity Search":"GROK-13162","Sequence Diversity Search":"GROK-13162",WebLogo:"GROK-13162",VdRegions:"GROK-13162"}[e]})}));const oe="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",ae="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",ce="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var le;(0,t.L1)("SeqHandler",(()=>{async function n(t){const n=e.DataFrame.fromCsv(t);await a.data.detectSemanticTypes(n);const r=u.GO.forColumn(n.getCol("seq"));return[n,r]}(0,t.t6)("Seq-Fasta",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA",(async()=>{const[e,r]=await n(ae);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!0)})),(0,t.t6)("Seq-Fasta-units",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA-units",(async()=>{const[e,r]=await n(ae);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!0)})),(0,t.t6)("Seq-Helm",(async()=>{const[e,r]=await n("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(r.notation,l.Hi.HELM),(0,t.E3)(r.isHelm(),!0)})),(0,t.t6)("Seq-UN",(async()=>{const[e,r]=await n(ce);(0,t.E3)(r.notation,l.Hi.SEPARATOR),(0,t.E3)(r.separator,"-"),(0,t.E3)(r.alphabet,l.YI.UN)})),(0,t.t6)("Seq-UN-auto",(async()=>{const[e,r]=await n(ce);(0,t.E3)(r.notation,l.Hi.SEPARATOR),(0,t.E3)(r.separator,"-"),(0,t.E3)(r.alphabet,l.YI.UN)})),(0,t.t6)("column-version",(async()=>{const n=e.DataFrame.fromCsv(oe);await a.data.detectSemanticTypes(n);const r=n.getCol("seq"),i=u.GO.forColumn(r),s=r.version,o=u.GO.forColumn(r),c=r.version;(0,t.E3)(s,c,"Unexpected column version changed"),(0,t.E3)(i,o,"Unexpected SeqHandler object changed"),n.rows.addNew(["TACCCCTTCAAC"]);const l=u.GO.forColumn(r),d=r.version;(0,t.E3)(c<d,!0,"Stalled column version on add row"),(0,t.E3)(o!==l,!0,"Stalled SeqHandler object on add row"),r.set(1,"CAGTGTCCCCGT");const h=u.GO.forColumn(r),p=r.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(l!==h,!0,"Stalled SeqHandler object on change data"),r.setTag("testTag","testValue");const m=u.GO.forColumn(r),f=r.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),function(e){e.fasta="fasta",e.fastaMsa="fastaMsa",e.separator="separator",e.separatorMsa="separatorMsa",e.helm="helm"}(le||(le={})),(0,t.L1)("SeqHandler",(()=>{u.b9[l.Hi.FASTA],u.b9[l.Hi.HELM];const n=u.b9[l.Hi.SEPARATOR],r={[le.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:l.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[le.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:l.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[le.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:l.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[le.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:l.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",n,"abc1","dfgg","rut12","her2","rty",n,"abc1","dfgg"],["rut2","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],["rut3","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],[n,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",n]]}},[le.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$"},tgt:{notation:l.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[n,i]of Object.entries(r))(0,t.t6)(`splitted-${n}`,(async()=>{const n=e.DataFrame.fromCsv(i.src.csv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r),(0,t.E3)(n.semType,e.SEMTYPE.MACROMOLECULE);const s=u.GO.forColumn(n);(0,t.E3)(s.notation,i.tgt.notation),(0,t.E3)(s.separator===i.tgt.separator,!0);const o=C().count(0).take(s.length).map((e=>C()(s.getSplitted(e).originals).toArray())).toArray();(0,t.J6)(o,i.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{const n={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:l.Hi.FASTA,alphabet:l.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:l.Hi.SEPARATOR,alphabet:l.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 3, 4, 4A, 4A, 4C",start:"4",end:null}},helm:{srcCsv:"seq\nPEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn]}$$$$\nPEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro]}$$$$\nPEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T}$$$$",startIdx:3,endIdx:6,tgtCsv:"seq\nPEPTIDE1{N.T.[dE].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.[dK].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.*.*}$$$$",units:l.Hi.HELM,alphabet:null,positionNames:{tag:null,start:"4",end:"7"}}};for(const[r,i]of Object.entries(n))(0,t.t6)(`${r}-idx`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=u.GO.forColumn(n).getRegion(i.startIdx,i.endIdx,"regSeq"),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(l.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(l.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())})),i.positionNames&&(0,t.t6)(`${r}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq");i.positionNames.tag&&n.setTag(l.gp.positionNames,i.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=await a.functions.call("Bio:getRegion",{sequence:n,start:i.positionNames.start,end:i.positionNames.end}),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(l.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(l.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const i={fasta:{src:{seq:"MDYKETMDYKET",notation:l.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:l.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:l.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:l.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(i))(0,t.t6)(e,(async()=>{await s(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function s(n,r,i,s){const o=e.Column.fromStrings("seq",[n]),c=e.DataFrame.fromColumns([o]);await a.data.detectSemanticTypes(c);const l=u.GO.forColumn(o),d=await l.getHelm(0,!1);(0,t.E3)(d,s)}}));var ue=n(7384),de=n(6717);const he=new e.FileSource("System:AppData/Bio"),pe={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},me="molfile(sequence)";async function fe(e,t="seq",n){await(0,de.j)();const r=e.getCol(t),i=n.getMonomerLib(),s=await(0,ue.C4)(e,r,i);return s.warnings.length>0&&_e.logger.warning(`_toAtomicLevel() warnings ${s.warnings.join("\n")}`),s.col}function ge(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map((e=>e.trimEnd())).join("\n")}(0,t.L1)("toAtomicLevel",(async()=>{const n={},r={};let i,s,o;async function d(e,n){const r=e.getCol("sequence");await(0,c.toAtomicLevel)(e,r,!1);const i=e.getCol(me),s=n.getCol(me),o=C()(i.values()).map((e=>ge(e))).toArray(),a=C()(s.values()).map((e=>ge(e))).toArray();(0,t.J6)(o,a)}(0,t.gM)((async()=>{i=await(0,L.pj)(),s=await(0,I.ub)(),await(0,I.yZ)(),await i.loadMonomerLib(!0);for(const[t,i]of Object.entries(pe))i.inPath,n[t]=e.DataFrame.fromCsv((await he.readAsText(i.inPath)).replace(/\n$/,"")),await a.data.detectSemanticTypes(n[t]),r[t]=e.DataFrame.fromCsv((await he.readAsText(i.outPath)).replace(/\n$/,""))})),(0,t.Pl)((async()=>{await(0,I.Eu)(s),await i.loadMonomerLib(!0)}));for(const[e,i]of Object.entries(pe))(0,t.t6)(`${e}`,(async()=>{await d(n[e],r[e])}));!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(o||(o={}));const h={[o.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[o.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[o.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[o.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[o.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[o.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[o.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[o.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[o.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function p(t){const n=h[t],r=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await a.data.detectSemanticTypes(r),r}(0,t.t6)("fastaDna",(async()=>{await fe(await p(o.fastaDna),"seq",i)})),(0,t.t6)("fastaRna",(async()=>{await fe(await p(o.fastaRna),"seq",i)})),(0,t.t6)("fastaPt",(async()=>{await fe(await p(o.fastaPt),"seq",i)})),(0,t.t6)("fastaUn",(async()=>{await fe(await p(o.fastaUn),"seq",i)})),(0,t.t6)("separatorDna",(async()=>{await fe(await p(o.separatorDna),"seq",i)})),(0,t.t6)("separatorDna",(async()=>{await fe(await p(o.separatorRna),"seq",i)})),(0,t.t6)("separatorPt",(async()=>{await fe(await p(o.separatorPt),"seq",i)})),(0,t.t6)("separatorUn",(async()=>{await fe(await p(o.separatorUn),"seq",i)})),(0,t.t6)("helm",(async()=>{await fe(await p(o.helm),"seq",i)})),(0,t.t6)("ptFasta2",(async()=>{const n=await _e.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),r=e.DataFrame.fromCsv("seq\nAR"),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.PT),u.GO.forColumn(s);const o=await fe(r,"seq",i);(0,t.E3)(ge(o.get(0)),ge(n))}))}));var ye=n(8754);(0,t.L1)("toAtomicLevel-ui",(()=>{let n,r,i;(0,t.gM)((async()=>{i=await(0,Q.b)(),n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const s="seq\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n";async function o(r,i,s){const o=await(0,ye.V)(r,i,s,n.getMonomerLib());(0,t.E3)(o.semType,e.SEMTYPE.MOLECULE)}(0,t.t6)("toAtomicLevel-fasta-linear",(async()=>{const t=e.DataFrame.fromCsv(s);await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!1)})),(0,t.t6)("toAtomicLevel-fasta-nonlinear",(async()=>{const t=e.DataFrame.fromCsv(s);await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!0)})),(0,t.t6)("toAtomicLevel-helm",(async()=>{const t=e.DataFrame.fromCsv("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.Aze.dV.E.N.dV.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.meM.D-Chg.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.D-Cit.N.D-Orn.D-aThr.Phe_4Me}$$$$\n");await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!0)}))}));var we=n(6863);async function be(t){const n=e.DataFrame.fromCsv(t),r=n.col("seq"),i=await a.functions.call("Bio:detectMacromolecule",{col:r});return i&&(r.semType=i),await a.data.detectSemanticTypes(n),u.GO.forColumn(r)}function ve(e,n,r,i){const s=r(e,n);(0,t.E3)(Number(s.toFixed(3)),Number(i.toFixed(3)))}(0,t.L1)("Distance",(async()=>{const n=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],r={F:0,W:1,R:2,Y:3},i="FWRWY",s="FWRWW",o="FWY",a="FWRWY",c="FWY",l="FWRRRRY";(0,t.t6)("protein-distance-function",(async()=>{const e=(await be("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP")).getDistanceFunctionName();(0,t.E3)(e,we.Z.LEVENSHTEIN)})),(0,t.t6)("DNA-distance-function",(async()=>{const e=(await be("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,we.Z.LEVENSHTEIN)})),(0,t.t6)("MSA-distance-function",(async()=>{const e=(await be("seq\nATAACATAAC\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,we.Z.HAMMING)})),(0,t.t6)("levenstein-sub",(async()=>{const e=we.V[we.Z.LEVENSHTEIN]();ve(i,s,e,.2)})),(0,t.t6)("levenstein-del",(async()=>{const e=we.V[we.Z.LEVENSHTEIN]();ve(o,a,e,.4)})),(0,t.t6)("hamming",(async()=>{const e=we.V[we.Z.HAMMING]();ve(o,a,e,.6)})),(0,t.t6)("needleman-blosum62",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});ve(i,s,e,-6)})),(0,t.t6)("needleman-blosum62-del",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});ve(o,a,e,-3.667)})),(0,t.t6)("needleman-custom-sub",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});ve(i,s,e,.2)})),(0,t.t6)("needleman-custom-del",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});ve(o,a,e,.667)})),(0,t.t6)("needleman-custom-zero-extend",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:0});ve(c,l,e,.333)})),(0,t.t6)("needleman-custom-half-extend",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:2,gapExtend:1});ve(c,l,e,1.667)})),(0,t.t6)("needleman-custom-same-extend",(async()=>{const t=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?ve(Array(1e3).fill(c).join(""),Array(1e3).fill(l).join(""),t,1.333):ve(c,l,t,1.333)}),{benchmark:!0})}));var Ae=n(684);async function Ee(e,n,r,i,s,o,l,u){await a.data.detectSemanticTypes(e);const d=await(0,c.activityCliffs)(e,e.getCol(r),e.getCol(i),s,n,l,u,{[`${Ae.vb}`]:!0});(0,t.E3)(null!=d,!0);const h=Array.from(d.root.children).find((e=>{const t=e.className.split(" ");return["ui-btn","ui-btn-ok"].every((e=>t.includes(e)))}));(0,t.E3)(h.innerText.toLowerCase(),`${o} cliffs`)}var Ce=n(2780),Te=n(9039);async function Se(n,r,i){const s=n.getCol(i),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const l=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!l)throw new Error("Preprocessing function not found");const u=await(0,c.sequenceSpaceTopMenu)(n,n.col(i),r,we.Z.LEVENSHTEIN,!0,l,{[Ae.vb]:!0});(0,t.E3)(null!=u,!0)}(0,t.L1)("activityCliffs",(async()=>{let n,r,i;const s=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],o=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)((async()=>{n=await(0,Q.b)(),r=await(0,L.pj)(),i=await(0,I.ub)(),await(0,I.yZ)(),await r.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("activityCliffsOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv",tgt:{cliffCount:53}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await _(t.fileName);a.shell.addTableView(n),await Ee(n,Te.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,we.Z.LEVENSHTEIN,s)}),{benchmark:!0}),(0,t.t6)("activityCliffsWithEmptyRows",(async()=>{const e=await _("tests/100_3_clustests_empty_vals.csv");a.shell.addTableView(e),await Ee(e,Te.c.UMAP,"sequence","Activity",90,3,we.Z.LEVENSHTEIN,s)})),(0,t.t6)("Helm",(async()=>{const e=await _e.files.readCsv("samples/HELM_50.csv");a.shell.addTableView(e),await Ee(e,Te.c.UMAP,"HELM","Activity",65,20,Ce.aT.Tanimoto,o)}))})),(0,t.L1)("sequenceSpace",(async()=>{let n,r,i,s;(0,t.t6)("sequenceSpaceOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await _(t.fileName),r=a.shell.addTableView(n),await Se(n,Te.c.UMAP,"sequence")}),{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",(async()=>{i=await _("tests/100_3_clustests_empty_vals.csv"),s=a.shell.addTableView(i),await Se(i,Te.c.UMAP,"sequence")}))})),(0,t.L1)("Scoring",(()=>{const n="sequence",r="expected_similarity",i="expected_identity",s=e.DataFrame.fromCsv(`${n},${r},${i}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.68,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.34,0.0`),o=s.getCol(n);o.meta.units=l.Hi.HELM,o.semType=e.SEMTYPE.MACROMOLECULE;const a=o.get(0);let u,d;(0,t.gM)((async()=>{u=await(0,c.getMonomerLibHelper)(),d=await(0,I.ub)(),await(0,I.yZ)(),await u.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(d),await u.loadMonomerLib(!0)})),(0,t.t6)("Identity",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,a);for(let n=0;n<e.length;n++){const r=e.get(n),o=s.get(i,n);(0,t.Wj)(r,o,.01,`Wrong identity score for sequence at position ${n}`)}})),(0,t.t6)("Identity-shortReference",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$");(0,t.E3)(C().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Identity-longReference",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$");(0,t.E3)(C().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Similarity",(async()=>{const e=await(0,c.sequenceSimilarityScoring)(s,o,a);for(let n=0;n<e.length;n++){const i=e.get(n),o=s.get(r,n);(0,t.Wj)(i,o,.01,`Wrong similarity score for sequence at position ${n}`)}}))}));const _e=new e.Package;async function xe(n,r,i,s){const o=await(0,t.N$)({category:n,test:r,testContext:i,stressTest:s});return e.DataFrame.fromObjects(o)}})(),bio_test=r})();
7
+ deps: ${n}}`};const o={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const r in e)"__proto__"!==r&&((Array.isArray(e[r])?t:n)[r]=e[r]);return[t,n]}(e);a(e,t),c(e,n)}};function a(e,t=e.schema){const{gen:n,data:i,it:o}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const c in t){const l=t[c];if(0===l.length)continue;const u=(0,s.propertyInData)(n,i,c,o.opts.ownProperties);e.setParams({property:c,depsCount:l.length,deps:l.join(", ")}),o.allErrors?n.if(u,(()=>{for(const t of l)(0,s.checkReportMissingProp)(e,t)})):(n.if(r._`${u} && (${(0,s.checkMissingProp)(e,l,a)})`),(0,s.reportMissingProp)(e,a),n.else())}}function c(e,t=e.schema){const{gen:n,data:r,keyword:o,it:a}=e,c=n.name("valid");for(const l in t)(0,i.alwaysValidSchema)(a,t[l])||(n.if((0,s.propertyInData)(n,r,l,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:o,schemaProp:l},c);e.mergeValidEvaluated(t,c)}),(()=>n.var(c,!0))),e.ok(c))}t.validatePropertyDeps=a,t.validateSchemaDeps=c,t.default=o},4845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3025),i={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,r.validateSchemaDeps)(e)};t.default=i},1239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>r.str`must match "${e.ifClause}" schema`,params:({params:e})=>r._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:s}=e;void 0===n.then&&void 0===n.else&&(0,i.checkStrictMode)(s,'"if" without "then" and "else" is ignored');const a=o(s,"then"),c=o(s,"else");if(!a&&!c)return;const l=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&c){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,d("then",n),d("else",n))}else a?t.if(u,d("then")):t.if((0,r.not)(u),d("else"));function d(n,i){return()=>{const s=e.subschema({keyword:n},u);t.assign(l,u),e.mergeValidEvaluated(s,l),i?t.assign(i,r._`${n}`):e.setParams({ifClause:n})}}e.pass(l,(()=>e.error(!0)))}};function o(e,t){const n=e.schema[t];return void 0!==n&&!(0,i.alwaysValidSchema)(e,n)}t.default=s},6378:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5457),i=n(5354),s=n(494),o=n(3966),a=n(2661),c=n(3025),l=n(9713),u=n(8660),d=n(117),h=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),w=n(4426);t.default=function(e=!1){const t=[p.default,m.default,f.default,g.default,y.default,w.default,l.default,u.default,c.default,d.default,h.default];return e?t.push(i.default,o.default):t.push(r.default,s.default),t.push(a.default),t}},494:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const r=n(9029),i=n(4227),s=n(5765),o={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,i.alwaysValidSchema)(n,t)||e.ok((0,s.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:s,parentSchema:o,data:a,keyword:c,it:l}=e;!function(e){const{opts:r,errSchemaPath:s}=l,o=n.length,a=o===e.minItems&&(o===e.maxItems||!1===e[t]);if(r.strictTuples&&!a){const e=`"${c}" is ${o}-tuple, but minItems or maxItems/${t} are not specified or different at path "${s}"`;(0,i.checkStrictMode)(l,e,r.strictTuples)}}(o),l.opts.unevaluated&&n.length&&!0!==l.items&&(l.items=i.mergeEvaluated.items(s,n.length,l.items));const u=s.name("valid"),d=s.const("len",r._`${a}.length`);n.forEach(((t,n)=>{(0,i.alwaysValidSchema)(l,t)||(s.if(r._`${d} > ${n}`,(()=>e.subschema({keyword:c,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=o},3966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(5765),o=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:r}=e,{prefixItems:a}=n;r.items=!0,(0,i.alwaysValidSchema)(r,t)||(a?(0,o.validateAdditionalItems)(e,a):e.ok((0,s.validateArray)(e)))}};t.default=a},7923:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:i}=e;if((0,r.alwaysValidSchema)(i,n))return void e.fail();const s=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},s),e.failResult(s,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=i},6163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>r._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:s,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(o.opts.discriminator&&s.discriminator)return;const a=n,c=t.let("valid",!1),l=t.let("passing",null),u=t.name("_valid");e.setParams({passing:l}),t.block((function(){a.forEach(((n,s)=>{let a;(0,i.alwaysValidSchema)(o,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:s,compositeRule:!0},u),s>0&&t.if(r._`${u} && ${c}`).assign(c,!1).assign(l,r._`[${l}, ${s}]`).else(),t.if(u,(()=>{t.assign(c,!0),t.assign(l,s),a&&e.mergeEvaluated(a,r.Name)}))}))})),e.result(c,(()=>e.reset()),(()=>e.error(!0)))}};t.default=s},5333:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(4227),o=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:c,it:l}=e,{opts:u}=l,d=(0,r.allSchemaProperties)(n),h=d.filter((e=>(0,s.alwaysValidSchema)(l,n[e])));if(0===d.length||h.length===d.length&&(!l.opts.unevaluated||!0===l.props))return;const p=u.strictSchema&&!u.allowMatchingProperties&&c.properties,m=t.name("valid");!0===l.props||l.props instanceof i.Name||(l.props=(0,o.evaluatedPropsToName)(t,l.props));const{props:f}=l;function g(e){for(const t in p)new RegExp(e).test(t)&&(0,s.checkStrictMode)(l,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(s=>{t.if(i._`${(0,r.usePattern)(e,n)}.test(${s})`,(()=>{const r=h.includes(n);r||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:s,dataPropType:o.Type.Str},m),l.opts.unevaluated&&!0!==f?t.assign(i._`${f}[${s}]`,!0):r||l.allErrors||t.if((0,i.not)(m),(()=>t.break()))}))}))}!function(){for(const e of d)p&&g(e),l.allErrors?y(e):(t.var(m,!0),y(e),t.if(m))}()}};t.default=a},5354:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(494),i={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,r.validateTuple)(e,"items")};t.default=i},117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2586),i=n(5765),s=n(4227),o=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:c,it:l}=e;"all"===l.opts.removeAdditional&&void 0===a.additionalProperties&&o.default.code(new r.KeywordCxt(l,o.default,"additionalProperties"));const u=(0,i.allSchemaProperties)(n);for(const e of u)l.definedProperties.add(e);l.opts.unevaluated&&u.length&&!0!==l.props&&(l.props=s.mergeEvaluated.props(t,(0,s.toHash)(u),l.props));const d=u.filter((e=>!(0,s.alwaysValidSchema)(l,n[e])));if(0===d.length)return;const h=t.name("valid");for(const n of d)p(n)?m(n):(t.if((0,i.propertyInData)(t,c,n,l.opts.ownProperties)),m(n),l.allErrors||t.else().var(h,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(h);function p(e){return l.opts.useDefaults&&!l.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},h)}}};t.default=a},9713:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>r._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:s,it:o}=e;if((0,i.alwaysValidSchema)(o,n))return;const a=t.name("valid");t.forIn("key",s,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,r.not)(a),(()=>{e.error(!0),o.allErrors||t.break()}))})),e.ok(a)}};t.default=s},4426:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,r.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=i},5765:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const r=n(9029),i=n(4227),s=n(2023),o=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:r._`Object.prototype.hasOwnProperty`})}function c(e,t,n){return r._`${a(e)}.call(${t}, ${n})`}function l(e,t,n,i){const s=r._`${t}${(0,r.getProperty)(n)} === undefined`;return i?(0,r.or)(s,(0,r.not)(c(e,t,n))):s}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:i,it:s}=e;n.if(l(n,i,t,s.opts.ownProperties),(()=>{e.setParams({missingProperty:r._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},i,s){return(0,r.or)(...i.map((i=>(0,r.and)(l(e,t,i,n.ownProperties),r._`${s} = ${i}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=c,t.propertyInData=function(e,t,n,i){const s=r._`${t}${(0,r.getProperty)(n)} !== undefined`;return i?r._`${s} && ${c(e,t,n)}`:s},t.noPropertyInData=l,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,i.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:i,schemaPath:o,errorPath:a},it:c},l,u,d){const h=d?r._`${e}, ${t}, ${i}${o}`:t,p=[[s.default.instancePath,(0,r.strConcat)(s.default.instancePath,a)],[s.default.parentData,c.parentData],[s.default.parentDataProperty,c.parentDataProperty],[s.default.rootData,s.default.rootData]];c.opts.dynamicRef&&p.push([s.default.dynamicAnchors,s.default.dynamicAnchors]);const m=r._`${h}, ${n.object(...p)}`;return u!==r.nil?r._`${l}.call(${u}, ${m})`:r._`${l}(${m})`};const d=r._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const i=t.unicodeRegExp?"u":"",{regExp:s}=t.code,a=s(n,i);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:r._`${"new RegExp"===s.code?d:(0,o.useFunc)(e,s)}(${n}, ${i})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:s,it:o}=e,a=t.name("valid");if(o.allErrors){const e=t.let("valid",!0);return c((()=>t.assign(e,!1))),e}return t.var(a,!0),c((()=>t.break())),a;function c(o){const c=t.const("len",r._`${n}.length`);t.forRange("i",0,c,(n=>{e.subschema({keyword:s,dataProp:n,dataPropType:i.Type.Num},a),t.if((0,r.not)(a),o)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:s,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,i.alwaysValidSchema)(o,e)))&&!o.opts.unevaluated)return;const a=t.let("valid",!1),c=t.name("_valid");t.block((()=>n.forEach(((n,i)=>{const o=e.subschema({keyword:s,schemaProp:i,compositeRule:!0},c);t.assign(a,r._`${a} || ${c}`),e.mergeValidEvaluated(o,c)||t.if((0,r.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},3463:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3463),i=n(3693),s=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",r.default,i.default];t.default=s},3693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const r=n(4551),i=n(5765),s=n(9029),o=n(2023),a=n(3835),c=n(4227),l={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:i}=e,{baseId:o,schemaEnv:c,validateName:l,opts:h,self:p}=i,{root:m}=c;if(("#"===n||"#/"===n)&&o===m.baseId)return function(){if(c===m)return d(e,l,c,c.$async);const n=t.scopeValue("root",{ref:m});return d(e,s._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,o,n);if(void 0===f)throw new r.default(i.opts.uriResolver,o,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);d(e,n,t,t.$async)}(f):function(r){const i=t.scopeValue("schema",!0===h.code.source?{ref:r,code:(0,s.stringify)(r)}:{ref:r}),o=t.name("valid"),a=e.subschema({schema:r,dataTypes:[],schemaPath:s.nil,topSchemaRef:i,errSchemaPath:n},o);e.mergeEvaluated(a),e.ok(o)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):s._`${n.scopeValue("wrapper",{ref:t})}.validate`}function d(e,t,n,r){const{gen:a,it:l}=e,{allErrors:u,schemaEnv:d,opts:h}=l,p=h.passContext?o.default.this:s.nil;function m(e){const t=s._`${e}.errors`;a.assign(o.default.vErrors,s._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`),a.assign(o.default.errors,s._`${o.default.vErrors}.length`)}function f(e){var t;if(!l.opts.unevaluated)return;const r=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==l.props)if(r&&!r.dynamicProps)void 0!==r.props&&(l.props=c.mergeEvaluated.props(a,r.props,l.props));else{const t=a.var("props",s._`${e}.evaluated.props`);l.props=c.mergeEvaluated.props(a,t,l.props,s.Name)}if(!0!==l.items)if(r&&!r.dynamicItems)void 0!==r.items&&(l.items=c.mergeEvaluated.items(a,r.items,l.items));else{const t=a.var("items",s._`${e}.evaluated.items`);l.items=c.mergeEvaluated.items(a,t,l.items,s.Name)}}r?function(){if(!d.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(s._`await ${(0,i.callValidateCode)(e,t,p)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(s._`!(${e} instanceof ${l.ValidationError})`,(()=>a.throw(e))),m(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,i.callValidateCode)(e,t,p),(()=>f(t)),(()=>m(t)))}t.getValidate=u,t.callRef=d,t.default=l},6653:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(7652),s=n(3835),o=n(4551),a=n(4227),c={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===i.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>r._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:c,parentSchema:l,it:u}=e,{oneOf:d}=l;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const h=c.propertyName;if("string"!=typeof h)throw new Error("discriminator: requires propertyName");if(c.mapping)throw new Error("discriminator: mapping is not supported");if(!d)throw new Error("discriminator: requires oneOf keyword");const p=t.let("valid",!1),m=t.const("tag",r._`${n}${(0,r.getProperty)(h)}`);function f(n){const i=t.name("valid"),s=e.subschema({keyword:"oneOf",schemaProp:n},i);return e.mergeEvaluated(s,r.Name),i}t.if(r._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=i(l);let r=!0;for(let t=0;t<d.length;t++){let l=d[t];if((null==l?void 0:l.$ref)&&!(0,a.schemaHasRulesButRef)(l,u.self.RULES)){const e=l.$ref;if(l=s.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),l instanceof s.SchemaEnv&&(l=l.schema),void 0===l)throw new o.default(u.opts.uriResolver,u.baseId,e)}const p=null===(e=null==l?void 0:l.properties)||void 0===e?void 0:e[h];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${h}"`);r=r&&(n||i(l)),c(p,t)}if(!r)throw new Error(`discriminator: "${h}" must be required`);return t;function i({required:e}){return Array.isArray(e)&&e.includes(h)}function c(e,t){if(e.const)p(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${h}" must have "const" or "enum"`);for(const n of e.enum)p(n,t)}}function p(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${h}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(r._`${m} === ${e}`),t.assign(p,f(n[e]));t.else(),e.error(!1,{discrError:i.DiscrError.Mapping,tag:m,tagName:h}),t.endIf()}()),(()=>e.error(!1,{discrError:i.DiscrError.Tag,tag:m,tagName:h}))),e.ok(p)}};t.default=c},7652:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2128),i=n(7060),s=n(6378),o=n(5520),a=n(5413),c=n(3265),l=n(7532),u=n(9857),d=[o.default,r.default,i.default,(0,s.default)(!0),l.default,u.metadataVocabulary,u.contentVocabulary,a.default,c.default];t.default=d},6144:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2128),i=n(7060),s=n(6378),o=n(7532),a=n(9857),c=[r.default,i.default,(0,s.default)(),o.default,a.metadataVocabulary,a.contentVocabulary];t.default=c},2476:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const r=n(9029),i=n(2023),s=n(3835),o=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>c(e,e.schema)};function c(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const c=r._`${i.default.dynamicAnchors}${(0,r.getProperty)(t)}`,l="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:r}=e.it,{root:i,baseId:a,localRefs:c,meta:l}=t.root,{schemaId:u}=r.opts,d=new s.SchemaEnv({schema:n,schemaId:u,root:i,baseId:a,localRefs:c,meta:l});return s.compileSchema.call(r,d),(0,o.getValidate)(e,d)}(e);n.if(r._`!${c}`,(()=>n.assign(c,l)))}t.dynamicAnchor=c,t.default=a},3252:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const r=n(9029),i=n(2023),s=n(3693),o={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:o,it:a}=e;if("#"!==t[0])throw new Error(`"${o}" only supports hash fragment reference`);const c=t.slice(1);if(a.allErrors)l();else{const t=n.let("valid",!1);l(t),e.ok(t)}function l(e){if(a.schemaEnv.root.dynamicAnchors[c]){const t=n.let("_v",r._`${i.default.dynamicAnchors}${(0,r.getProperty)(c)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,r){return r?()=>n.block((()=>{(0,s.callRef)(e,t),n.let(r,!0)})):()=>(0,s.callRef)(e,t)}}t.dynamicRef=a,t.default=o},5520:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2476),i=n(3252),s=n(2721),o=n(3799),a=[r.default,i.default,s.default,o.default];t.default=a},2721:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(2476),i=n(4227),s={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,r.dynamicAnchor)(e,""):(0,i.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=s},3799:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3252),i={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,r.dynamicRef)(e,e.schema)};t.default=i},4737:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match format "${e}"`,params:({schemaCode:e})=>r._`{format: ${e}}`},code(e,t){const{gen:n,data:i,$data:s,schema:o,schemaCode:a,it:c}=e,{opts:l,errSchemaPath:u,schemaEnv:d,self:h}=c;l.validateFormats&&(s?function(){const s=n.scopeValue("formats",{ref:h.formats,code:l.code.formats}),o=n.const("fDef",r._`${s}[${a}]`),c=n.let("fType"),u=n.let("format");n.if(r._`typeof ${o} == "object" && !(${o} instanceof RegExp)`,(()=>n.assign(c,r._`${o}.type || "string"`).assign(u,r._`${o}.validate`)),(()=>n.assign(c,r._`"string"`).assign(u,o))),e.fail$data((0,r.or)(!1===l.strictSchema?r.nil:r._`${a} && !${u}`,function(){const e=d.$async?r._`(${o}.async ? await ${u}(${i}) : ${u}(${i}))`:r._`${u}(${i})`,n=r._`(typeof ${u} == "function" ? ${e} : ${u}.test(${i}))`;return r._`${u} && ${u} !== true && ${c} === ${t} && !${n}`}()))}():function(){const s=h.formats[o];if(!s)return void function(){if(!1!==l.strictSchema)throw new Error(e());function e(){return`unknown format "${o}" ignored in schema at path "${u}"`}h.logger.warn(e())}();if(!0===s)return;const[a,c,p]=function(e){const t=e instanceof RegExp?(0,r.regexpCode)(e):l.code.formats?r._`${l.code.formats}${(0,r.getProperty)(o)}`:void 0,i=n.scopeValue("formats",{key:o,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,i]:[e.type||"string",e.validate,r._`${i}.validate`]}(s);a===t&&e.pass(function(){if("object"==typeof s&&!(s instanceof RegExp)&&s.async){if(!d.$async)throw new Error("async format in sync schema");return r._`await ${p}(${i})`}return"function"==typeof c?r._`${p}(${i})`:r._`${p}.test(${i})`}())}())}};t.default=i},7532:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=[n(4737).default];t.default=r},9857:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(1846),i=n(4845),s=n(2626),o=[r.default,i.default,s.default];t.default=o},3265:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(392),i=n(3445),s=[r.default,i.default];t.default=s},3445:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>r.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>r._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:s,it:o}=e,a=o.items||0;if(!0===a)return;const c=t.const("len",r._`${s}.length`);if(!1===n)e.setParams({len:a}),e.fail(r._`${c} > ${a}`);else if("object"==typeof n&&!(0,i.alwaysValidSchema)(o,n)){const n=t.var("valid",r._`${c} <= ${a}`);t.if((0,r.not)(n),(()=>function(n,s){t.forRange("i",s,c,(s=>{e.subschema({keyword:"unevaluatedItems",dataProp:s,dataPropType:i.Type.Num},n),o.allErrors||t.if((0,r.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}o.items=!0}};t.default=s},392:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(2023),o={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>r._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:o,errsCount:a,it:c}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:l,props:u}=c;function d(s){if(!1===n)return e.setParams({unevaluatedProperty:s}),e.error(),void(l||t.break());if(!(0,i.alwaysValidSchema)(c,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:s,dataPropType:i.Type.Str},n),l||t.if((0,r.not)(n),(()=>t.break()))}}u instanceof r.Name?t.if(r._`${u} !== true`,(()=>t.forIn("key",o,(e=>t.if(function(e,t){return r._`!${e} || !${e}[${t}]`}(u,e),(()=>d(e))))))):!0!==u&&t.forIn("key",o,(e=>void 0===u?d(e):t.if(function(e,t){const n=[];for(const i in e)!0===e[i]&&n.push(r._`${t} !== ${i}`);return(0,r.and)(...n)}(u,e),(()=>d(e))))),c.props=!0,e.ok(r._`${a} === ${s.default.errors}`)}};t.default=o},7935:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(6250),o={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>r._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:o,schemaCode:a,schema:c}=e;o||c&&"object"==typeof c?e.fail$data(r._`!${(0,i.useFunc)(t,s.default)}(${n}, ${a})`):e.fail(r._`${c} !== ${n}`)}};t.default=o},1846:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(3025),i={keyword:"dependentRequired",type:"object",schemaType:"object",error:r.error,code:e=>(0,r.validatePropertyDeps)(e)};t.default=i},8643:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(6250),o={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>r._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:o,schema:a,schemaCode:c,it:l}=e;if(!o&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=l.opts.loopEnum;let d;const h=()=>null!=d?d:d=(0,i.useFunc)(t,s.default);let p;if(u||o)p=t.let("valid"),e.block$data(p,(function(){t.assign(p,!1),t.forOf("v",c,(e=>t.if(r._`${h()}(${n}, ${e})`,(()=>t.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",c);p=(0,r.or)(...a.map(((t,i)=>function(e,t){const i=a[t];return"object"==typeof i&&null!==i?r._`${h()}(${n}, ${e}[${t}])`:r._`${n} === ${i}`}(e,i))))}e.pass(p)}};t.default=o},7060:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5882),i=n(3439),s=n(7307),o=n(422),a=n(4486),c=n(4003),l=n(1163),u=n(617),d=n(7935),h=n(8643),p=[r.default,i.default,s.default,o.default,a.default,c.default,l.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},d.default,h.default];t.default=p},2626:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(4227),i={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,r.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=i},1163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:i}=e,s="maxItems"===t?r.operators.GT:r.operators.LT;e.fail$data(r._`${n}.length ${s} ${i}`)}};t.default=i},7307:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=n(4227),s=n(3853),o={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o,it:a}=e,c="maxLength"===t?r.operators.GT:r.operators.LT,l=!1===a.opts.unicode?r._`${n}.length`:r._`${(0,i.useFunc)(e.gen,s.default)}(${n})`;e.fail$data(r._`${l} ${c} ${o}`)}};t.default=o},5882:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i=r.operators,s={maximum:{okStr:"<=",ok:i.LTE,fail:i.GT},minimum:{okStr:">=",ok:i.GTE,fail:i.LT},exclusiveMaximum:{okStr:"<",ok:i.LT,fail:i.GTE},exclusiveMinimum:{okStr:">",ok:i.GT,fail:i.LTE}},o={message:({keyword:e,schemaCode:t})=>r.str`must be ${s[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>r._`{comparison: ${s[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(s),type:"number",schemaType:"number",$data:!0,error:o,code(e){const{keyword:t,data:n,schemaCode:i}=e;e.fail$data(r._`${n} ${s[t].fail} ${i} || isNaN(${n})`)}};t.default=a},4486:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return r.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>r._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:i}=e,s="maxProperties"===t?r.operators.GT:r.operators.LT;e.fail$data(r._`Object.keys(${n}).length ${s} ${i}`)}};t.default=i},3439:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(9029),i={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>r.str`must be multiple of ${e}`,params:({schemaCode:e})=>r._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:i,it:s}=e,o=s.opts.multipleOfPrecision,a=t.let("res"),c=o?r._`Math.abs(Math.round(${a}) - ${a}) > 1e-${o}`:r._`${a} !== parseInt(${a})`;e.fail$data(r._`(${i} === 0 || (${a} = ${n}/${i}, ${c}))`)}};t.default=i},422:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match pattern "${e}"`,params:({schemaCode:e})=>i._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:s,schemaCode:o,it:a}=e,c=a.opts.unicodeRegExp?"u":"",l=n?i._`(new RegExp(${o}, ${c}))`:(0,r.usePattern)(e,s);e.fail$data(i._`!${l}.test(${t})`)}};t.default=s},4003:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(5765),i=n(9029),s=n(4227),o={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>i.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>i._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:o,data:a,$data:c,it:l}=e,{opts:u}=l;if(!c&&0===n.length)return;const d=n.length>=u.loopRequired;if(l.allErrors?function(){if(d||c)e.block$data(i.nil,h);else for(const t of n)(0,r.checkReportMissingProp)(e,t)}():function(){const s=t.let("missing");if(d||c){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,s){e.setParams({missingProperty:n}),t.forOf(n,o,(()=>{t.assign(s,(0,r.propertyInData)(t,a,n,u.ownProperties)),t.if((0,i.not)(s),(()=>{e.error(),t.break()}))}),i.nil)}(s,n))),e.ok(n)}else t.if((0,r.checkMissingProp)(e,n,s)),(0,r.reportMissingProp)(e,s),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:r}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!r.has(e)){const t=`required property "${e}" is not defined at "${l.schemaEnv.baseId+l.errSchemaPath}" (strictRequired)`;(0,s.checkStrictMode)(l,t,l.opts.strictRequired)}}function h(){t.forOf("prop",o,(n=>{e.setParams({missingProperty:n}),t.if((0,r.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=o},617:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const r=n(208),i=n(9029),s=n(4227),o=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>i.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>i._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:c,parentSchema:l,schemaCode:u,it:d}=e;if(!a&&!c)return;const h=t.let("valid"),p=l.items?(0,r.getSchemaTypes)(l.items):[];function m(s,o){const a=t.name("item"),c=(0,r.checkDataTypes)(p,a,d.opts.strictNumbers,r.DataType.Wrong),l=t.const("indices",i._`{}`);t.for(i._`;${s}--;`,(()=>{t.let(a,i._`${n}[${s}]`),t.if(c,i._`continue`),p.length>1&&t.if(i._`typeof ${a} == "string"`,i._`${a} += "_"`),t.if(i._`typeof ${l}[${a}] == "number"`,(()=>{t.assign(o,i._`${l}[${a}]`),e.error(),t.assign(h,!1).break()})).code(i._`${l}[${a}] = ${s}`)}))}function f(r,a){const c=(0,s.useFunc)(t,o.default),l=t.name("outer");t.label(l).for(i._`;${r}--;`,(()=>t.for(i._`${a} = ${r}; ${a}--;`,(()=>t.if(i._`${c}(${n}[${r}], ${n}[${a}])`,(()=>{e.error(),t.assign(h,!1).break(l)}))))))}e.block$data(h,(function(){const r=t.let("i",i._`${n}.length`),s=t.let("j");e.setParams({i:r,j:s}),t.assign(h,!0),t.if(i._`${r} > 1`,(()=>(p.length>0&&!p.some((e=>"object"===e||"array"===e))?m:f)(r,s)))}),i._`${u} === false`),e.ok(h)}};t.default=a},5488:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=o},5999:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},857:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}"],sourceRoot:""}]);const a=o},6369:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},7939:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=o},3017:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var r=n(1354),i=n.n(r),s=n(6314),o=n.n(s)()(i());o.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=o},6314:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",r=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),r&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),r&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,r,i,s){"string"==typeof e&&(e=[[null,e,void 0]]);var o={};if(r)for(var a=0;a<this.length;a++){var c=this[a][0];null!=c&&(o[c]=!0)}for(var l=0;l<e.length;l++){var u=[].concat(e[l]);r&&o[u[0]]||(void 0!==s&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=s),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),i&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=i):u[4]="".concat(i)),t.push(u))}},t}},1354:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var r=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),i="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(r),s="/*# ".concat(i," */");return[t].concat([s]).join("\n")}return[t].join("\n")}},2017:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var r,i,s;if(Array.isArray(t)){if((r=t.length)!=n.length)return!1;for(i=r;0!=i--;)if(!e(t[i],n[i]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((r=(s=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(i=r;0!=i--;)if(!Object.prototype.hasOwnProperty.call(n,s[i]))return!1;for(i=r;0!=i--;){var o=s[i];if(!e(t[o],n[o]))return!1}return!0}return t!=t&&n!=n}},9982:function(e,t,n){var r;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,r,i,s){for(var o,a,c,l,u,d,h,p,m,f,g,y,w;s>=64;){for(o=n[0],a=n[1],c=n[2],l=n[3],u=n[4],d=n[5],h=n[6],p=n[7],f=0;f<16;f++)g=i+4*f,e[f]=(255&r[g])<<24|(255&r[g+1])<<16|(255&r[g+2])<<8|255&r[g+3];for(f=16;f<64;f++)y=((m=e[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,w=((m=e[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,e[f]=(y+e[f-7]|0)+(w+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&d^~u&h)|0)+(p+(t[f]+e[f]|0)|0)|0,w=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&c^a&c)|0,p=h,h=d,d=u,u=l+y|0,l=c,c=a,a=o,o=y+w|0;n[0]+=o,n[1]+=a,n[2]+=c,n[3]+=l,n[4]+=u,n[5]+=d,n[6]+=h,n[7]+=p,i+=64,s-=64}return i}var r=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var r=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[r++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(r=n(this.temp,this.state,e,r,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[r++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,r=this.bufferLength,i=t/536870912|0,s=t<<3,o=t%64<56?64:128;this.buffer[r]=128;for(var a=r+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=i>>>24&255,this.buffer[o-7]=i>>>16&255,this.buffer[o-6]=i>>>8&255,this.buffer[o-5]=i>>>0&255,this.buffer[o-4]=s>>>24&255,this.buffer[o-3]=s>>>16&255,this.buffer[o-2]=s>>>8&255,this.buffer[o-1]=s>>>0&255,n(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=r;var i=function(){function e(e){this.inner=new r,this.outer=new r,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new r).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function s(e){var t=(new r).update(e),n=t.digest();return t.clean(),n}function o(e,t){var n=new i(e).update(t),r=n.digest();return n.clean(),r}function a(e,t,n,r){var i=r[0];if(0===i)throw new Error("hkdf: cannot expand more");t.reset(),i>1&&t.update(e),n&&t.update(n),t.update(r),t.finish(e),r[0]++}e.HMAC=i,e.hash=s,e.default=s,e.hmac=o;var c=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,r){void 0===t&&(t=c),void 0===r&&(r=32);for(var s=new Uint8Array([1]),l=o(t,e),u=new i(l),d=new Uint8Array(u.digestLength),h=d.length,p=new Uint8Array(r),m=0;m<r;m++)h===d.length&&(a(d,u,n,s),h=0),p[m]=d[h++];return u.clean(),d.fill(0),s.fill(0),p},e.pbkdf2=function(e,t,n,r){for(var s=new i(e),o=s.digestLength,a=new Uint8Array(4),c=new Uint8Array(o),l=new Uint8Array(o),u=new Uint8Array(r),d=0;d*o<r;d++){var h=d+1;a[0]=h>>>24&255,a[1]=h>>>16&255,a[2]=h>>>8&255,a[3]=h>>>0&255,s.reset(),s.update(t),s.update(a),s.finish(l);for(var p=0;p<o;p++)c[p]=l[p];for(p=2;p<=n;p++){s.reset(),s.update(l).finish(l);for(var m=0;m<o;m++)c[m]^=l[m]}for(p=0;p<o&&d*o+p<r;p++)u[d*o+p]=c[p]}for(d=0;d<o;d++)c[d]=l[d]=0;for(d=0;d<4;d++)a[d]=0;return s.clean(),u}}(t);var i=t.default;for(var s in t)i[s]=t[s];"object"==typeof e.exports?e.exports=i:void 0===(r=function(){return i}.call(t,n,t,e))||(e.exports=r)}()},2787:(e,t,n)=>{"use strict";n.d(t,{I:()=>i});const r=new Uint32Array(65536),i=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,i=t.length,s=1<<n-1;let o=-1,a=0,c=n,l=n;for(;l--;)r[e.charCodeAt(l)]|=1<<l;for(l=0;l<i;l++){let e=r[t.charCodeAt(l)];const n=e|a;e|=(e&o)+o^o,a|=~(e|o),o&=e,a&s&&c++,o&s&&c--,a=a<<1|1,o=o<<1|~(n|a),a&=n}for(l=n;l--;)r[e.charCodeAt(l)]=0;return c})(e,t):((e,t)=>{const n=t.length,i=e.length,s=[],o=[],a=Math.ceil(n/32),c=Math.ceil(i/32);for(let e=0;e<a;e++)o[e]=-1,s[e]=0;let l=0;for(;l<c-1;l++){let a=0,c=-1;const u=32*l,d=Math.min(32,i)+u;for(let t=u;t<d;t++)r[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=r[t.charCodeAt(e)],i=o[e/32|0]>>>e&1,l=s[e/32|0]>>>e&1,u=n|a,d=((n|l)&c)+c^c|n|l;let h=a|~(d|c),p=c&d;h>>>31^i&&(o[e/32|0]^=1<<e),p>>>31^l&&(s[e/32|0]^=1<<e),h=h<<1|i,p=p<<1|l,c=p|~(u|h),a=h&u}for(let t=u;t<d;t++)r[e.charCodeAt(t)]=0}let u=0,d=-1;const h=32*l,p=Math.min(32,i-h)+h;for(let t=h;t<p;t++)r[e.charCodeAt(t)]|=1<<t;let m=i;for(let e=0;e<n;e++){const n=r[t.charCodeAt(e)],a=o[e/32|0]>>>e&1,c=s[e/32|0]>>>e&1,l=n|u,h=((n|c)&d)+d^d|n|c;let p=u|~(h|d),f=d&h;m+=p>>>i-1&1,m-=f>>>i-1&1,p>>>31^a&&(o[e/32|0]^=1<<e),f>>>31^c&&(s[e/32|0]^=1<<e),p=p<<1|a,f=f<<1|c,d=f|~(l|p),u=p&l}for(let t=h;t<p;t++)r[e.charCodeAt(t)]=0;return m})(e,t)}},9937:e=>{e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(e,t)=>{t.assign=function(e){e=e||{};var t,n,r,i=Array.prototype.slice.call(arguments).slice(1);for(t=0,r=i.length;t<r;t++)if(i[t])for(n in i[t])e[n]=i[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,r=e.order,i=e.size,s={},o=new Float32Array(10*r),a=new Float32Array(3*i);return n=0,e.forEachNode((function(e,t){s[e]=n,o[n]=t.x,o[n+1]=t.y,o[n+2]=0,o[n+3]=0,o[n+4]=0,o[n+5]=0,o[n+6]=1,o[n+7]=1,o[n+8]=t.size||1,o[n+9]=t.fixed?1:0,n+=10})),n=0,e.forEachEdge((function(e,r,i,c,l,u,d){var h=s[i],p=s[c],m=t(e,r,i,c,l,u,d);o[h+6]+=m,o[p+6]+=m,a[n]=h,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:o,edges:a}},t.assignLayoutChanges=function(e,t,n){var r=0;e.updateEachNodeAttributes((function(e,i){return i.x=t[r],i.y=t[r+1],r+=10,n?n(e,i):i}))},t.readGraphPositions=function(e,t){var n=0;e.forEachNode((function(e,r){t[n]=r.x,t[n+1]=r.y,n+=10}))},t.collectLayoutChanges=function(e,t,n){for(var r=e.nodes(),i={},s=0,o=0,a=t.length;s<a;s+=10){if(n){var c=Object.assign({},e.getNodeAttributes(r[o]));c.x=t[s],c.y=t[s+1],c=n(r[o],c),i[r[o]]={x:c.x,y:c.y}}else i[r[o]]={x:t[s],y:t[s+1]};o++}return i},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),r=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),i=new Worker(r);return t.revokeObjectURL(r),i}},8903:(e,t,n)=>{var r=n(1736),i=n(8153).Fd,s=n(2561),o=n(1782),a=n(9937);function c(e,t,n){if(!r(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var c=n.iterations;if("number"!=typeof c)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(c<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var l=i("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,d=o.assign({},a,n.settings),h=o.validateSettings(d);if(h)throw new Error("graphology-layout-forceatlas2: "+h.message);var p,m=o.graphToByteArrays(t,l);for(p=0;p<c;p++)s(d,m.nodes,m.edges);if(!e)return o.collectLayoutChanges(t,m.nodes);o.assignLayoutChanges(t,m.nodes,u)}var l=c.bind(null,!1);l.assign=c.bind(null,!0),l.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=l},2561:e=>{var t=10;e.exports=function(e,n,r){var i,s,o,a,c,l,u,d,h,p,m,f,g,y,w,b,v,A,E,C,T,S,_,P=n.length,x=r.length,M=e.adjustSizes,$=e.barnesHutTheta*e.barnesHutTheta,N=[];for(o=0;o<P;o+=t)n[o+4]=n[o+2],n[o+5]=n[o+3],n[o+2]=0,n[o+3]=0;if(e.outboundAttractionDistribution){for(m=0,o=0;o<P;o+=t)m+=n[o+6];m/=P/t}if(e.barnesHutOptimize){var L,I,R,O=1/0,k=-1/0,G=1/0,H=-1/0;for(o=0;o<P;o+=t)O=Math.min(O,n[o+0]),k=Math.max(k,n[o+0]),G=Math.min(G,n[o+1]),H=Math.max(H,n[o+1]);var D=k-O,F=H-G;for(D>F?H=(G-=(D-F)/2)+D:k=(O-=(F-D)/2)+F,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+H)/2,N[3]=Math.max(k-O,H-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,i=1,o=0;o<P;o+=t)for(s=0,R=3;;){if(!(N[s+5]>=0)){if(N[s+0]<0){N[s+0]=o;break}if(N[s+5]=9*i,d=N[s+3]/2,N[(h=N[s+5])+0]=-1,N[h+1]=N[s+1]-d,N[h+2]=N[s+2]-d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]-d,N[h+2]=N[s+2]+d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]+d,N[h+2]=N[s+2]-d,N[h+3]=d,N[h+4]=h+9,N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,N[(h+=9)+0]=-1,N[h+1]=N[s+1]+d,N[h+2]=N[s+2]+d,N[h+3]=d,N[h+4]=N[s+4],N[h+5]=-1,N[h+6]=0,N[h+7]=0,N[h+8]=0,i+=4,L=n[N[s+0]+0]<N[s+1]?n[N[s+0]+1]<N[s+2]?N[s+5]:N[s+5]+9:n[N[s+0]+1]<N[s+2]?N[s+5]+18:N[s+5]+27,N[s+6]=n[N[s+0]+6],N[s+7]=n[N[s+0]+0],N[s+8]=n[N[s+0]+1],N[L+0]=N[s+0],N[s+0]=-1,L===(I=n[o+0]<N[s+1]?n[o+1]<N[s+2]?N[s+5]:N[s+5]+9:n[o+1]<N[s+2]?N[s+5]+18:N[s+5]+27)){if(R--){s=L;continue}R=3;break}N[I+0]=o;break}L=n[o+0]<N[s+1]?n[o+1]<N[s+2]?N[s+5]:N[s+5]+9:n[o+1]<N[s+2]?N[s+5]+18:N[s+5]+27,N[s+7]=(N[s+7]*N[s+6]+n[o+0]*n[o+6])/(N[s+6]+n[o+6]),N[s+8]=(N[s+8]*N[s+6]+n[o+1]*n[o+6])/(N[s+6]+n[o+6]),N[s+6]+=n[o+6],s=L}}if(e.barnesHutOptimize){for(f=e.scalingRatio,o=0;o<P;o+=t)for(s=0;;)if(N[s+5]>=0){if(b=Math.pow(n[o+0]-N[s+7],2)+Math.pow(n[o+1]-N[s+8],2),4*(p=N[s+3])*p/b<$){if(g=n[o+0]-N[s+7],y=n[o+1]-N[s+8],!0===M?b>0?(v=f*n[o+6]*N[s+6]/b,n[o+2]+=g*v,n[o+3]+=y*v):b<0&&(v=-f*n[o+6]*N[s+6]/Math.sqrt(b),n[o+2]+=g*v,n[o+3]+=y*v):b>0&&(v=f*n[o+6]*N[s+6]/b,n[o+2]+=g*v,n[o+3]+=y*v),(s=N[s+4])<0)break;continue}s=N[s+5]}else if((l=N[s+0])>=0&&l!==o&&(b=(g=n[o+0]-n[l+0])*g+(y=n[o+1]-n[l+1])*y,!0===M?b>0?(v=f*n[o+6]*n[l+6]/b,n[o+2]+=g*v,n[o+3]+=y*v):b<0&&(v=-f*n[o+6]*n[l+6]/Math.sqrt(b),n[o+2]+=g*v,n[o+3]+=y*v):b>0&&(v=f*n[o+6]*n[l+6]/b,n[o+2]+=g*v,n[o+3]+=y*v)),(s=N[s+4])<0)break}else for(f=e.scalingRatio,a=0;a<P;a+=t)for(c=0;c<a;c+=t)g=n[a+0]-n[c+0],y=n[a+1]-n[c+1],!0===M?(b=Math.sqrt(g*g+y*y)-n[a+8]-n[c+8])>0?(v=f*n[a+6]*n[c+6]/b/b,n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v):b<0&&(v=100*f*n[a+6]*n[c+6],n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v):(b=Math.sqrt(g*g+y*y))>0&&(v=f*n[a+6]*n[c+6]/b/b,n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v);for(h=e.gravity/e.scalingRatio,f=e.scalingRatio,o=0;o<P;o+=t)v=0,g=n[o+0],y=n[o+1],b=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.strongGravityMode?b>0&&(v=f*n[o+6]*h):b>0&&(v=f*n[o+6]*h/b),n[o+2]-=g*v,n[o+3]-=y*v;for(f=1*(e.outboundAttractionDistribution?m:1),u=0;u<x;u+=3)a=r[u+0],c=r[u+1],d=r[u+2],w=Math.pow(d,e.edgeWeightInfluence),g=n[a+0]-n[c+0],y=n[a+1]-n[c+1],!0===M?(b=Math.sqrt(g*g+y*y)-n[a+8]-n[c+8],e.linLogMode?e.outboundAttractionDistribution?b>0&&(v=-f*w*Math.log(1+b)/b/n[a+6]):b>0&&(v=-f*w*Math.log(1+b)/b):e.outboundAttractionDistribution?b>0&&(v=-f*w/n[a+6]):b>0&&(v=-f*w)):(b=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?b>0&&(v=-f*w*Math.log(1+b)/b/n[a+6]):b>0&&(v=-f*w*Math.log(1+b)/b):e.outboundAttractionDistribution?(b=1,v=-f*w/n[a+6]):(b=1,v=-f*w)),b>0&&(n[a+2]+=g*v,n[a+3]+=y*v,n[c+2]-=g*v,n[c+3]-=y*v);if(!0===M)for(o=0;o<P;o+=t)1!==n[o+9]&&((A=Math.sqrt(Math.pow(n[o+2],2)+Math.pow(n[o+3],2)))>10&&(n[o+2]=10*n[o+2]/A,n[o+3]=10*n[o+3]/A),E=n[o+6]*Math.sqrt((n[o+4]-n[o+2])*(n[o+4]-n[o+2])+(n[o+5]-n[o+3])*(n[o+5]-n[o+3])),C=Math.sqrt((n[o+4]+n[o+2])*(n[o+4]+n[o+2])+(n[o+5]+n[o+3])*(n[o+5]+n[o+3]))/2,T=.1*Math.log(1+C)/(1+Math.sqrt(E)),S=n[o+0]+n[o+2]*(T/e.slowDown),n[o+0]=S,_=n[o+1]+n[o+3]*(T/e.slowDown),n[o+1]=_);else for(o=0;o<P;o+=t)1!==n[o+9]&&(E=n[o+6]*Math.sqrt((n[o+4]-n[o+2])*(n[o+4]-n[o+2])+(n[o+5]-n[o+3])*(n[o+5]-n[o+3])),C=Math.sqrt((n[o+4]+n[o+2])*(n[o+4]+n[o+2])+(n[o+5]+n[o+3])*(n[o+5]+n[o+3]))/2,T=n[o+7]*Math.log(1+C)/(1+Math.sqrt(E)),n[o+7]=Math.min(1,Math.sqrt(T*(Math.pow(n[o+2],2)+Math.pow(n[o+3],2))/(1+Math.sqrt(E)))),S=n[o+0]+n[o+2]*(T/e.slowDown),n[o+0]=S,_=n[o+1]+n[o+3]*(T/e.slowDown),n[o+1]=_);return{}}},8153:(e,t)=>{function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},r=function(e){return void 0===e?t:e};"function"==typeof t&&(r=t);var i=function(t){return r(t[e])},s=function(){return r(void 0)};return"string"==typeof e?(n.fromAttributes=i,n.fromGraph=function(e,t){return i(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return i(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var i=t.extremities(n);return r(e(n,t.getEdgeAttributes(n),i[0],i[1],t.getNodeAttributes(i[0]),t.getNodeAttributes(i[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,i,s,o,a,c){return r(e(t,n,i,s,o,a,c))},n.fromPartialEntry=function(t,n,i,s){return r(e(t,n,i,s))},n.fromMinimalEntry=function(t,n){return r(e(t,n))}):(n.fromAttributes=s,n.fromGraph=s,n.fromEntry=s,n.fromMinimalEntry=s),n}(e,n)}},1736:e=>{e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934:function(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,r(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function r(e,t){return r=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},r(e,t)}function i(e,t,n){return i=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var i=[null];i.push.apply(i,t);var s=new(Function.bind.apply(e,i));return n&&r(s,n.prototype),s},i.apply(null,arguments)}function s(e){var t="function"==typeof Map?new Map:void 0;return s=function(e){if(null===e||(s=e,-1===Function.toString.call(s).indexOf("[native code]")))return e;var s;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,o)}function o(){return i(e,arguments,n(this).constructor)}return o.prototype=Object.create(e.prototype,{constructor:{value:o,enumerable:!1,writable:!0,configurable:!0}}),r(o,e)},s(e)}function o(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var r in arguments[t])e[r]=arguments[t][r];return e};function c(e,t,n,r){var i=e._nodes.get(t),s=null;return i?s="mixed"===r?i.out&&i.out[n]||i.undirected&&i.undirected[n]:"directed"===r?i.out&&i.out[n]:i.undirected&&i.undirected[n]:s}function l(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function d(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function h(e,t,n){var r={enumerable:!0,configurable:!0};"function"==typeof n?r.get=n:(r.value=n,r.writable=!1),Object.defineProperty(e,t,r)}function p(e){return!(!l(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var w=Number.isNaN||function(e){return e!=e};function b(){b.init.call(this)}f.exports=b,f.exports.once=function(e,t){return new Promise((function(n,r){function i(n){e.removeListener(t,s),r(n)}function s(){"function"==typeof e.removeListener&&e.removeListener("error",i),n([].slice.call(arguments))}M(e,t,s,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&M(e,"error",t,{once:!0})}(e,i)}))},b.EventEmitter=b,b.prototype._events=void 0,b.prototype._eventsCount=0,b.prototype._maxListeners=void 0;var v=10;function A(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function E(e){return void 0===e._maxListeners?b.defaultMaxListeners:e._maxListeners}function C(e,t,n,r){var i,s,o,a;if(A(n),void 0===(s=e._events)?(s=e._events=Object.create(null),e._eventsCount=0):(void 0!==s.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),s=e._events),o=s[t]),void 0===o)o=s[t]=n,++e._eventsCount;else if("function"==typeof o?o=s[t]=r?[n,o]:[o,n]:r?o.unshift(n):o.push(n),(i=E(e))>0&&o.length>i&&!o.warned){o.warned=!0;var c=new Error("Possible EventEmitter memory leak detected. "+o.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");c.name="MaxListenersExceededWarning",c.emitter=e,c.type=t,c.count=o.length,a=c,console&&console.warn&&console.warn(a)}return e}function T(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function S(e,t,n){var r={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},i=T.bind(r);return i.listener=n,r.wrapFn=i,i}function _(e,t,n){var r=e._events;if(void 0===r)return[];var i=r[t];return void 0===i?[]:"function"==typeof i?n?[i.listener||i]:[i]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(i):x(i,i.length)}function P(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function x(e,t){for(var n=new Array(t),r=0;r<t;++r)n[r]=e[r];return n}function M(e,t,n,r){if("function"==typeof e.on)r.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,(function i(s){r.once&&e.removeEventListener(t,i),n(s)}))}}function $(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(b,"defaultMaxListeners",{enumerable:!0,get:function(){return v},set:function(e){if("number"!=typeof e||e<0||w(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");v=e}}),b.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},b.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||w(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},b.prototype.getMaxListeners=function(){return E(this)},b.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var r="error"===e,i=this._events;if(void 0!==i)r=r&&void 0===i.error;else if(!r)return!1;if(r){var s;if(t.length>0&&(s=t[0]),s instanceof Error)throw s;var o=new Error("Unhandled error."+(s?" ("+s.message+")":""));throw o.context=s,o}var a=i[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var c=a.length,l=x(a,c);for(n=0;n<c;++n)y(l[n],this,t)}return!0},b.prototype.addListener=function(e,t){return C(this,e,t,!1)},b.prototype.on=b.prototype.addListener,b.prototype.prependListener=function(e,t){return C(this,e,t,!0)},b.prototype.once=function(e,t){return A(t),this.on(e,S(this,e,t)),this},b.prototype.prependOnceListener=function(e,t){return A(t),this.prependListener(e,S(this,e,t)),this},b.prototype.removeListener=function(e,t){var n,r,i,s,o;if(A(t),void 0===(r=this._events))return this;if(void 0===(n=r[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete r[e],r.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(i=-1,s=n.length-1;s>=0;s--)if(n[s]===t||n[s].listener===t){o=n[s].listener,i=s;break}if(i<0)return this;0===i?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,i),1===n.length&&(r[e]=n[0]),void 0!==r.removeListener&&this.emit("removeListener",e,o||t)}return this},b.prototype.off=b.prototype.removeListener,b.prototype.removeAllListeners=function(e){var t,n,r;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var i,s=Object.keys(n);for(r=0;r<s.length;++r)"removeListener"!==(i=s[r])&&this.removeAllListeners(i);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(r=t.length-1;r>=0;r--)this.removeListener(e,t[r]);return this},b.prototype.listeners=function(e){return _(this,e,!0)},b.prototype.rawListeners=function(e){return _(this,e,!1)},b.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):P.call(e,t)},b.prototype.listenerCount=P,b.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&($.prototype[Symbol.iterator]=function(){return this}),$.of=function(){var e=arguments,t=e.length,n=0;return new $((function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}}))},$.empty=function(){return new $((function(){return{done:!0}}))},$.fromSequence=function(e){var t=0,n=e.length;return new $((function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}}))},$.is=function(e){return e instanceof $||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=$,L={};L.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,L.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var I=N,R=L,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?I.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},H=G,D=function(e,t){for(var n,r=arguments.length>1?t:1/0,i=r!==1/0?new Array(r):[],s=0,o=H(e);;){if(s===r)return i;if((n=o.next()).done)return s!==t&&(i.length=s),i;i[s++]=n.value}},F=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(s(Error)),U=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F),V=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F),Y=function(e){function n(t){var r;return(r=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(o(r),n.prototype.constructor),r}return t(n,e),n}(F);function B(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function j(e,t){this.key=e,this.attributes=t,this.clear()}function K(e,t,n,r,i){this.key=t,this.attributes=i,this.undirected=e,this.source=n,this.target=r}function q(e,t,n,r,i,s,o){var a,c,l,u;if(r=""+r,0===n){if(!(a=e._nodes.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" node in the graph.'));l=i,u=s}else if(3===n){if(i=""+i,!(c=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));var d=c.source.key,h=c.target.key;if(r===d)a=c.target;else{if(r!==h)throw new V("Graph.".concat(t,': the "').concat(r,'" node is not attached to the "').concat(i,'" edge (').concat(d,", ").concat(h,")."));a=c.source}l=s,u=o}else{if(!(c=e._edges.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" edge in the graph.'));a=1===n?c.source:c.target,l=i,u=s}return[a,l,u]}B.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},j.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},K.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,r=this.target.key;this.source[e][r]=this,this.undirected&&n===r||(this.target[t][n]=this)},K.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,r=this.target.key;this.undirected&&(e=t="undirected");var i=this.source[e],s=i[r];if(void 0===s)return i[r]=this,void(this.undirected&&n===r||(this.target[t][n]=this));s.previous=this,this.next=s,i[r]=this,this.target[t][n]=this},K.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",r="in";this.undirected&&(n=r="undirected"),delete this.source[n][t],delete this.target[r][e]},K.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",r="in";this.undirected&&(n=r="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[r][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[r][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return o.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){return q(this,t,n,e,r)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return o.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i,s){var o=q(this,t,n,e,r,i,s),a=o[0],c=o[1],l=o[2];return a.attributes[c]=l,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:c}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i,s){var o=q(this,t,n,e,r,i,s),a=o[0],c=o[1],l=o[2];if("function"!=typeof l)throw new U("Graph.".concat(t,": updater should be a function."));var u=a.attributes,d=l(u[c]);return u[c]=d,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:c}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];return delete o.attributes[a],this.emit("nodeAttributesUpdated",{key:o.key,type:"remove",attributes:o.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];if(!l(a))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return o.attributes=a,this.emit("nodeAttributesUpdated",{key:o.key,type:"replace",attributes:o.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],c=s[1];if(!l(c))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return a(o.attributes,c),this.emit("nodeAttributesUpdated",{key:o.key,type:"merge",attributes:o.attributes,data:c}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s=q(this,t,n,e,r,i),o=s[0],a=s[1];if("function"!=typeof a)throw new U("Graph.".concat(t,": provided updater is not a function."));return o.attributes=a(o.attributes),this.emit("nodeAttributesUpdated",{key:o.key,type:"update",attributes:o.attributes}),this}}}],z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes[r]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var i=""+e,s=""+arguments[1];if(!(r=c(this,i,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(i,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes.hasOwnProperty(r)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,a=""+r;if(r=arguments[2],i=arguments[3],!(s=c(this,o,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(s=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return s.attributes[r]=i,this.emit("edgeAttributesUpdated",{key:s.key,type:"set",attributes:s.attributes,name:r}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r,i){var s;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,a=""+r;if(r=arguments[2],i=arguments[3],!(s=c(this,o,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(s=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new U("Graph.".concat(t,": updater should be a function."));return s.attributes[r]=i(s.attributes[r]),this.emit("edgeAttributesUpdated",{key:s.key,type:"set",attributes:s.attributes,name:r}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete i.attributes[r],this.emit("edgeAttributesUpdated",{key:i.key,type:"remove",attributes:i.attributes,name:r}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!l(r))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return i.attributes=r,this.emit("edgeAttributesUpdated",{key:i.key,type:"replace",attributes:i.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!l(r))throw new U("Graph.".concat(t,": provided attributes are not a plain object."));return a(i.attributes,r),this.emit("edgeAttributesUpdated",{key:i.key,type:"merge",attributes:i.attributes,data:r}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,r){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new Y("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new Y("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,o=""+r;if(r=arguments[2],!(i=c(this,s,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new Y("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof r)throw new U("Graph.".concat(t,": provided updater is not a function."));return i.attributes=r(i.attributes),this.emit("edgeAttributesUpdated",{key:i.key,type:"update",attributes:i.attributes}),this}}}],X=N,J=G,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var r=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(r=t.next()).done)break;t=null}return r}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,r){var i=!1;for(var s in t)if(s!==r){var o=t[s];if(i=n(o.key,o.attributes,o.source.key,o.target.key,o.source.attributes,o.target.attributes,o.undirected),e&&i)return o.key}}function ne(e,t,n,r){var i,s,o,a=!1;for(var c in t)if(c!==r){i=t[c];do{if(s=i.source,o=i.target,a=n(i.key,i.attributes,s.key,o.key,s.attributes,o.attributes,i.undirected),e&&a)return i.key;i=i.next}while(void 0!==i)}}function re(e,t){var n,r=Object.keys(e),i=r.length,s=0;return new N((function(){do{if(n)n=n.next;else{if(s>=i)return{done:!0};var o=r[s++];if(o===t){n=void 0;continue}n=e[o]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function ie(e,t,n,r){var i=t[n];if(i){var s=i.source,o=i.target;return r(i.key,i.attributes,s.key,o.key,s.attributes,o.attributes,i.undirected)&&e?i.key:void 0}}function se(e,t,n,r){var i=t[n];if(i){var s=!1;do{if(s=r(i.key,i.attributes,i.source.key,i.target.key,i.source.attributes,i.target.attributes,i.undirected),e&&s)return i.key;i=i.next}while(void 0!==i)}}function oe(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,r){if(0!==t.size)for(var i,s,o="mixed"!==n&&n!==t.type,a="undirected"===n,c=!1,l=t._edges.values();!0!==(i=l.next()).done;)if(s=i.value,!o||s.undirected===a){var u=s,d=u.key,h=u.attributes,p=u.source,m=u.target;if(c=r(d,h,p.key,m.key,p.attributes,m.attributes,s.undirected),e&&c)return d}}function ce(e,t,n,r,i,s){var o,a=t?ne:te;if("undirected"!==n){if("out"!==r&&(o=a(e,i.in,s),e&&o))return o;if("in"!==r&&(o=a(e,i.out,s,r?void 0:i.key),e&&o))return o}if("directed"!==n&&(o=a(e,i.undirected,s),e&&o))return o}function le(e,t,n,r,i,s,o){var a,c=n?se:ie;if("undirected"!==t){if(void 0!==i.in&&"out"!==r&&(a=c(e,i.in,s,o),e&&a))return a;if(void 0!==i.out&&"in"!==r&&(r||i.key!==s)&&(a=c(e,i.out,s,o),e&&a))return a}if("directed"!==t&&void 0!==i.undirected&&(a=c(e,i.undirected,s,o),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function de(){this.A=null,this.B=null}function he(e,t,n,r,i){for(var s in r){var o=r[s],a=o.source,c=o.target,l=a===n?c:a;if(!t||!t.has(l.key)){var u=i(l.key,l.attributes);if(e&&u)return l.key}}}function pe(e,t,n,r,i){if("mixed"!==t){if("undirected"===t)return he(e,null,r,r.undirected,i);if("string"==typeof n)return he(e,null,r,r[n],i)}var s,o=new de;if("undirected"!==t){if("out"!==n){if(s=he(e,null,r,r.in,i),e&&s)return s;o.wrap(r.in)}if("in"!==n){if(s=he(e,o,r,r.out,i),e&&s)return s;o.wrap(r.out)}}if("directed"!==t&&(s=he(e,o,r,r.undirected,i),e&&s))return s}function me(e,t,n){var r=Object.keys(n),i=r.length,s=0;return new N((function(){var o=null;do{if(s>=i)return e&&e.wrap(n),{done:!0};var a=n[r[s++]],c=a.source,l=a.target;o=c===t?l:c,e&&e.has(o.key)&&(o=null)}while(null===o);return{done:!1,value:{neighbor:o.key,attributes:o.attributes}}}))}function fe(e,t,n,r,i){for(var s,o,a,c,l,u,d,h=r._nodes.values(),p=r.type;!0!==(s=h.next()).done;){var m=!1;if(o=s.value,"undirected"!==p)for(a in c=o.out){l=c[a];do{if(u=l.target,m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if("directed"!==p)for(a in c=o.undirected)if(!(t&&o.key>a)){l=c[a];do{if((u=l.target).key!==a&&(u=l.source),m=!0,d=i(o.key,u.key,o.attributes,u.attributes,l.key,l.attributes,l.undirected),e&&d)return l;l=l.next}while(l)}if(n&&!m&&(d=i(o.key,null,o.attributes,null,null,null,null),e&&d))return null}}function ge(e){if(!l(e))throw new U('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new U("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!l(e))throw new U('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new U("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new U("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!l(e.attributes)||null===e.attributes))throw new U("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new U("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}de.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},de.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var we,be=(we=255&Math.floor(256*Math.random()),function(){return we++}),ve=new Set(["directed","undirected","mixed"]),Ae=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ee={allowSelfLoops:!0,multi:!1,type:"mixed"};function Ce(e,t,n){var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}function Te(e,t,n,r,i,s,o,a){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!l(a))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(s=""+s,o=""+o,a=a||{},!e.allowSelfLoops&&s===o)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var c=e._nodes.get(s),u=e._nodes.get(o);if(!c)throw new V("Graph.".concat(t,': source node "').concat(s,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(o,'" not found.'));var d={key:null,undirected:r,source:s,target:o,attributes:a};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new Y("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));if(!e.multi&&(r?void 0!==c.undirected[o]:void 0!==c.out[o]))throw new Y("Graph.".concat(t,': an edge linking "').concat(s,'" to "').concat(o,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var h=new K(r,i,c,u,a);e._edges.set(i,h);var p=s===o;return r?(c.undirectedDegree++,u.undirectedDegree++,p&&(c.undirectedLoops++,e._undirectedSelfLoopCount++)):(c.outDegree++,u.inDegree++,p&&(c.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,d.key=i,e.emit("edgeAdded",d),i}function Se(e,t,n,r,i,s,o,c,u){if(!r&&"undirected"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(r&&"directed"===e.type)throw new Y("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(c)if(u){if("function"!=typeof c)throw new U("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(c,'"'))}else if(!l(c))throw new U("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(c,'"'));var d;if(s=""+s,o=""+o,u&&(d=c,c=void 0),!e.allowSelfLoops&&s===o)throw new Y("Graph.".concat(t,': source & target are the same ("').concat(s,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var h,p,m=e._nodes.get(s),f=e._nodes.get(o);if(!n&&(h=e._edges.get(i))){if(!(h.source.key===s&&h.target.key===o||r&&h.source.key===o&&h.target.key===s))throw new Y("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(i,'" edge with "').concat(s,'" source & "').concat(o,'" target vs. ("').concat(h.source.key,'", "').concat(h.target.key,'").'));p=h}if(p||e.multi||!m||(p=r?m.undirected[o]:m.out[o]),p){var g=[p.key,!1,!1,!1];if(u?!d:!c)return g;if(u){var y=p.attributes;p.attributes=d(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,c),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:c});return g}c=c||{},u&&d&&(c=d(c));var w={key:null,undirected:r,source:s,target:o,attributes:c};if(n)i=e._edgeKeyGenerator();else if(i=""+i,e._edges.has(i))throw new Y("Graph.".concat(t,': the "').concat(i,'" edge already exists in the graph.'));var b=!1,v=!1;m||(m=Ce(e,s,{}),b=!0,s===o&&(f=m,v=!0)),f||(f=Ce(e,o,{}),v=!0),h=new K(r,i,m,f,c),e._edges.set(i,h);var A=s===o;return r?(m.undirectedDegree++,f.undirectedDegree++,A&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,A&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?h.attachMulti():h.attach(),r?e._undirectedSize++:e._directedSize++,w.key=i,e.emit("edgeAdded",w),[i,!0,b,v]}function _e(e,t){e._edges.delete(t.key);var n=t.source,r=t.target,i=t.attributes,s=t.undirected,o=n===r;s?(n.undirectedDegree--,r.undirectedDegree--,o&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,r.inDegree--,o&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),s?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:i,source:n.key,target:r.key,undirected:s})}var Pe=function(n){function r(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ee,e)).multi)throw new U("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!ve.has(e.type))throw new U('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new U("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var r="mixed"===e.type?B:"directed"===e.type?W:j;d(o(t),"NodeDataClass",r);var i="geid_"+be()+"_",s=0;return d(o(t),"_attributes",{}),d(o(t),"_nodes",new Map),d(o(t),"_edges",new Map),d(o(t),"_directedSize",0),d(o(t),"_undirectedSize",0),d(o(t),"_directedSelfLoopCount",0),d(o(t),"_undirectedSelfLoopCount",0),d(o(t),"_edgeKeyGenerator",(function(){var e;do{e=i+s++}while(t._edges.has(e));return e})),d(o(t),"_options",e),Ae.forEach((function(e){return d(o(t),e,t[e])})),h(o(t),"order",(function(){return t._nodes.size})),h(o(t),"size",(function(){return t._edges.size})),h(o(t),"directedSize",(function(){return t._directedSize})),h(o(t),"undirectedSize",(function(){return t._undirectedSize})),h(o(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),h(o(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),h(o(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),h(o(t),"multi",t._options.multi),h(o(t),"type",t._options.type),h(o(t),"allowSelfLoops",t._options.allowSelfLoops),h(o(t),"implementation",(function(){return"graphology"})),t}t(r,n);var i=r.prototype;return i._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},i.hasNode=function(e){return this._nodes.has(""+e)},i.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&!r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.out.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,r=this._edges.get(n);return!!r&&r.undirected}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&i.undirected.hasOwnProperty(t)}throw new U("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&(void 0!==r.out&&r.out.hasOwnProperty(t)||void 0!==r.undirected&&r.undirected.hasOwnProperty(t))}throw new U("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},i.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||void 0;return r?r.key:void 0}},i.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new Y("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.undirected&&n.undirected[t]||void 0;return r?r.key:void 0}},i.edge=function(e,t){if(this.multi)throw new Y("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var r=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(r)return r.key},i.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},i.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},i.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},i.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},i.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},i.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},i.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},i.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},i.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},i.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},i.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},i.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},i.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},i.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},i.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},i.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},i.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},i.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},i.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,r+=t.directedLoops),n-r},i.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,r+=t.directedLoops),n-r},i.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,r=0;return"directed"!==this.type&&(n+=t.undirectedDegree,r+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,r+=2*t.directedLoops),n-r},i.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},i.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},i.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},i.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var r=n.source.key,i=n.target.key;if(e===r)return i;if(e===i)return r;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(r,", ").concat(i,")."))},i.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},i.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},i.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},i.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},i.addNode=function(e,t){var n=function(e,t,n){if(n&&!l(n))throw new U('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new Y('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var r=new e.NodeDataClass(t,n);return e._nodes.set(t,r),e.emit("nodeAdded",{key:t,attributes:n}),r}(this,e,t);return n.key},i.mergeNode=function(e,t){if(t&&!l(t))throw new U('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},i.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new U('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var r=n.attributes;n.attributes=t(r),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var i=t?t({}):{};return n=new this.NodeDataClass(e,i),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:i}),[e,!0]},i.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var r in n.out){t=n.out[r];do{_e(this,t),t=t.next}while(t)}for(var i in n.in){t=n.in[i];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var s in n.undirected){t=n.undirected[s];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},i.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],r=""+arguments[1];if(!(t=c(this,n,r,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(r,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},i.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new Y("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new Y("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=c(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},i.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},i.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},i.getAttribute=function(e){return this._attributes[e]},i.getAttributes=function(){return this._attributes},i.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},i.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.updateAttribute=function(e,t){if("function"!=typeof t)throw new U("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},i.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},i.replaceAttributes=function(e){if(!l(e))throw new U("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},i.mergeAttributes=function(e){if(!l(e))throw new U("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},i.updateAttributes=function(e){if("function"!=typeof e)throw new U("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},i.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i=this._nodes.values();!0!==(n=i.next()).done;)(r=n.value).attributes=e(r.key,r.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},i.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new U("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new U("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,r,i,s,o=this._edges.values();!0!==(n=o.next()).done;)i=(r=n.value).source,s=r.target,r.attributes=e(r.key,r.attributes,i.key,s.key,i.attributes,s.attributes,r.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},i.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},i.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},i.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},i.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new U("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},i.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):D(this._nodes.keys(),this._nodes.size)},i.forEachNode=function(e){if("function"!=typeof e)throw new U("Graph.forEachNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)},i.findNode=function(e){if("function"!=typeof e)throw new U("Graph.findNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},i.mapNodes=function(e){if("function"!=typeof e)throw new U("Graph.mapNode: expecting a callback.");for(var t,n,r=this._nodes.values(),i=new Array(this.order),s=0;!0!==(t=r.next()).done;)n=t.value,i[s++]=e(n.key,n.attributes);return i},i.someNode=function(e){if("function"!=typeof e)throw new U("Graph.someNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},i.everyNode=function(e){if("function"!=typeof e)throw new U("Graph.everyNode: expecting a callback.");for(var t,n,r=this._nodes.values();!0!==(t=r.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},i.filterNodes=function(e){if("function"!=typeof e)throw new U("Graph.filterNodes: expecting a callback.");for(var t,n,r=this._nodes.values(),i=[];!0!==(t=r.next()).done;)e((n=t.value).key,n.attributes)&&i.push(n.key);return i},i.reduceNodes=function(e,t){if("function"!=typeof e)throw new U("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new U("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,r,i=t,s=this._nodes.values();!0!==(n=s.next()).done;)i=e(i,(r=n.value).key,r.attributes);return i},i.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},i.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,r){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(r,e)}));var r=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,i){r[n++]=function(e,t,n){var r={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(r.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(r.undirected=!0),r}(e.type,i,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:r}},i.import=function(e){var t,n,i,s,o,a=this,c=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof r)return e.forEachNode((function(e,t){c?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,r,i,s,o){c?o?a.mergeUndirectedEdgeWithKey(e,n,r,t):a.mergeDirectedEdgeWithKey(e,n,r,t):o?a.addUndirectedEdgeWithKey(e,n,r,t):a.addDirectedEdgeWithKey(e,n,r,t)})),this;if(!l(e))throw new U("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!l(e.attributes))throw new U("Graph.import: invalid attributes. Expecting a plain object.");c?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(i=e.nodes,!Array.isArray(i))throw new U("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=i.length;t<n;t++){ge(s=i[t]);var u=s,d=u.key,h=u.attributes;c?this.mergeNode(d,h):this.addNode(d,h)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),i=e.edges,!Array.isArray(i))throw new U("Graph.import: invalid edges. Expecting an array.");for(t=0,n=i.length;t<n;t++){ye(o=i[t]);var m=o,f=m.source,g=m.target,y=m.attributes,w=m.undirected,b=void 0===w?p:w;"key"in o?(c?b?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:b?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,o.key,f,g,y):(c?b?this.mergeUndirectedEdge:this.mergeDirectedEdge:b?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},i.nullCopy=function(e){var t=new r(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},i.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var r=a({},e.attributes);e=new t.NodeDataClass(n,r),t._nodes.set(n,e)})),t},i.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new Y('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new Y("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new Y("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,r=this.emptyCopy(e),i=this._edges.values();!0!==(t=i.next()).done;)Te(r,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return r},i.toJSON=function(){return this.export()},i.toString=function(){return"[object Graph]"},i.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var r={},i={};this._edges.forEach((function(e,n){var s,o=e.undirected?"--":"->",a="",c=e.source.key,l=e.target.key;e.undirected&&c>l&&(s=c,c=l,l=s);var u="(".concat(c,")").concat(o,"(").concat(l,")");n.startsWith("geid_")?t.multi&&(void 0===i[u]?i[u]=0:i[u]++,a+="".concat(i[u],". ")):a+="[".concat(n,"]: "),r[a+=u]=e.attributes}));var s={};for(var o in this)this.hasOwnProperty(o)&&!Ae.has(o)&&"function"!=typeof this[o]&&"symbol"!==e(o)&&(s[o]=this[o]);return s.attributes=this._attributes,s.nodes=n,s.edges=r,d(s,"constructor",this.constructor),s},r}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(Pe.prototype[Symbol.for("nodejs.util.inspect.custom")]=Pe.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(e){["add","merge","update"].forEach((function(t){var n=e.name(t),r="add"===t?Te:Se;e.generateKey?Pe.prototype[n]=function(i,s,o){return r(this,n,!0,"undirected"===(e.type||this.type),null,i,s,o,"update"===t)}:Pe.prototype[n]=function(i,s,o,a){return r(this,n,!1,"undirected"===(e.type||this.type),i,s,o,a,"update"===t)}}))})),function(e){Z.forEach((function(t){var n=t.name,r=t.attacher;r(e,n("Node"),0),r(e,n("Source"),1),r(e,n("Target"),2),r(e,n("Opposite"),3)}))}(Pe),function(e){z.forEach((function(t){var n=t.name,r=t.attacher;r(e,n("Edge"),"mixed"),r(e,n("DirectedEdge"),"directed"),r(e,n("UndirectedEdge"),"undirected")}))}(Pe),function(e){ee.forEach((function(t){!function(e,t){var n=t.name,r=t.type,i=t.direction;e.prototype[n]=function(e,t){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):D(e._edges.keys(),e._edges.size);for(var n,r,i="undirected"===t?e.undirectedSize:e.directedSize,s=new Array(i),o="undirected"===t,a=e._edges.values(),c=0;!0!==(n=a.next()).done;)(r=n.value).undirected===o&&(s[c++]=r.key);return s}(this,r);if(1===arguments.length){e=""+e;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,r){var i=[];return ce(!1,e,t,n,r,(function(e){i.push(e)})),i}(this.multi,"mixed"===r?this.type:r,i,s)}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);if(!o)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,r,i){var s=[];return le(!1,e,t,n,r,i,(function(e){s.push(e)})),s}(r,this.multi,i,o,t)}throw new U("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t,n){if("mixed"===r||"mixed"===this.type||r===this.type){if(1===arguments.length)return ae(!1,this,r,n=e);if(2===arguments.length){e=""+e,n=t;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return ce(!1,this.multi,"mixed"===r?this.type:r,i,o,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return le(!1,r,this.multi,i,a,t,n)}throw new U("Graph.".concat(s,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var o="map"+n[0].toUpperCase()+n.slice(1);e.prototype[o]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var i=0;"directed"!==r&&(i+=this.undirectedSize),"undirected"!==r&&(i+=this.directedSize),e=new Array(i);var o=0;t.push((function(t,r,i,s,a,c,l){e[o++]=n(t,r,i,s,a,c,l)}))}else e=[],t.push((function(t,r,i,s,o,a,c){e.push(n(t,r,i,s,o,a,c))}));return this[s].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push((function(e,r,i,s,o,a,c){t(e,r,i,s,o,a,c)&&n.push(e)})),this[s].apply(this,e),n};var c="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[c]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new U("Graph.".concat(c,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new U("Graph.".concat(c,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var r=t;return n.push((function(t,n,i,s,o,a,c){r=e(r,t,n,i,s,o,a,c)})),this[s].apply(this,n),r}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t,n){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return!1;if(1===arguments.length)return ae(!0,this,r,n=e);if(2===arguments.length){e=""+e,n=t;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return ce(!0,this.multi,"mixed"===r?this.type:r,i,o,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return le(!0,r,this.multi,i,a,t,n)}throw new U("Graph.".concat(s,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var o="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,r,i,s,o,a){return t(e,n,r,i,s,o,a)})),!!this[s].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,r,i,s,o,a){return!t(e,n,r,i,s,o,a)})),!this[s].apply(this,e)}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n.slice(0,-1)+"Entries";e.prototype[s]=function(e,t){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,r="undirected"===t,i=e._edges.values();return new N((function(){for(var e,t;;){if((e=i.next()).done)return e;if(t=e.value,!n||t.undirected===r)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}}))}(this,r);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var r=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(r=Q(r,re(n.in))),"in"!==t&&void 0!==n.out&&(r=Q(r,re(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(r=Q(r,re(n.undirected))),r}(r,i,n)}if(2===arguments.length){e=""+e,t=""+t;var o=this._nodes.get(e);if(!o)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(s,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,r){var i=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&r in n.in&&(i=Q(i,oe(n.in,r))),void 0!==n.out&&"in"!==t&&r in n.out&&(t||n.key!==r)&&(i=Q(i,oe(n.out,r)))),"directed"!==e&&void 0!==n.undirected&&r in n.undirected&&(i=Q(i,oe(n.undirected,r))),i}(r,i,o,t)}throw new U("Graph.".concat(s,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)}))}(Pe),function(e){ue.forEach((function(t){(function(e,t){var n=t.name,r=t.type,i=t.direction;e.prototype[n]=function(e){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var r=[];return pe(!1,e,t,n,(function(e){r.push(e)})),r}("mixed"===r?this.type:r,i,t)}})(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(e,t){if("mixed"===r||"mixed"===this.type||r===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));pe(!1,"mixed"===r?this.type:r,i,n,t)}};var o="map"+n[0].toUpperCase()+n.slice(1);e.prototype[o]=function(e,t){var n=[];return this[s](e,(function(e,r){n.push(t(e,r))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[s](e,(function(e,r){t(e,r)&&n.push(e)})),n};var c="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[c]=function(e,t,n){if(arguments.length<3)throw new U("Graph.".concat(c,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var r=n;return this[s](e,(function(e,n){r=t(r,e,n)})),r}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n[0].toUpperCase()+n.slice(1,-1),o="find"+s;e.prototype[o]=function(e,t){if("mixed"===r||"mixed"===this.type||r===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return pe(!0,"mixed"===r?this.type:r,i,n,t)}};var a="some"+s;e.prototype[a]=function(e,t){return!!this[o](e,t)};var c="every"+s;e.prototype[c]=function(e,t){return!this[o](e,(function(e,n){return!t(e,n)}))}}(e,t),function(e,t){var n=t.name,r=t.type,i=t.direction,s=n.slice(0,-1)+"Entries";e.prototype[s]=function(e){if("mixed"!==r&&"mixed"!==this.type&&r!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return me(null,n,n.undirected);if("string"==typeof t)return me(null,n,n[t])}var r=N.empty(),i=new de;return"undirected"!==e&&("out"!==t&&(r=Q(r,me(i,n,n.in))),"in"!==t&&(r=Q(r,me(i,n,n.out)))),"directed"!==e&&(r=Q(r,me(i,n,n.undirected))),r}("mixed"===r?this.type:r,i,t)}}(e,t)}))}(Pe);var xe=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new U("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new U('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Pe),Me=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new U("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new U('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Pe),$e=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Pe),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new U('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Pe),Le=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new U("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new U('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Pe);function Ie(e){e.from=function(t,n){var r=a({},t.options,n),i=new e(r);return i.import(t),i}}return Ie(Pe),Ie(xe),Ie(Me),Ie($e),Ie(Ne),Ie(Le),Pe.Graph=Pe,Pe.DirectedGraph=xe,Pe.UndirectedGraph=Me,Pe.MultiGraph=$e,Pe.MultiDirectedGraph=Ne,Pe.MultiUndirectedGraph=Le,Pe.InvalidArgumentsGraphError=U,Pe.NotFoundGraphError=V,Pe.UsageGraphError=Y,Pe}()},944:(e,t)=>{"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var r=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var r=0,i=e.length,s=t.length,o=Math.floor(Math.max(i,s)/2)-1,a=new Array(i),c=new Array(s),l=0;l<i;l++)for(var u=Math.max(0,l-o);u<=Math.min(s,l+o+1);u++)if(!a[l]&&!c[u]&&e[l]===t[u]){++r,a[l]=c[u]=!0;break}if(0===r)return 0;var d=0,h=0;for(l=0;l<i;l++)if(a[l]){for(;!c[h];)h++;e.charAt(l)!==t.charAt(h++)&&d++}return(r/i+r/s+(r-(d/=2))/r)/3}(e,t,n),i=0;if(r>.7){for(var s=Math.min(e.length,t.length),o=0;e[o]===t[o]&&o<4&&o<s;)++i,o++;r+=.1*i*(1-r)}return r}},7106:e=>{"use strict";var t=e.exports=function(e,t,r){"function"==typeof t&&(r=t,t={}),n(t,"function"==typeof(r=t.cb||r)?r:r.pre||function(){},r.post||function(){},e,"",e)};function n(e,r,i,s,o,a,c,l,u,d){if(s&&"object"==typeof s&&!Array.isArray(s)){for(var h in r(s,o,a,c,l,u,d),s){var p=s[h];if(Array.isArray(p)){if(h in t.arrayKeywords)for(var m=0;m<p.length;m++)n(e,r,i,p[m],o+"/"+h+"/"+m,a,o,h,s,m)}else if(h in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,r,i,p[f],o+"/"+h+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,o,h,s,f)}else(h in t.keywords||e.allKeys&&!(h in t.skipKeywords))&&n(e,r,i,p,o+"/"+h,a,o,h,s)}i(s,o,a,c,l,u,d)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:e=>{"use strict";var t=[];function n(e){for(var n=-1,r=0;r<t.length;r++)if(t[r].identifier===e){n=r;break}return n}function r(e,r){for(var s={},o=[],a=0;a<e.length;a++){var c=e[a],l=r.base?c[0]+r.base:c[0],u=s[l]||0,d="".concat(l," ").concat(u);s[l]=u+1;var h=n(d),p={css:c[1],media:c[2],sourceMap:c[3],supports:c[4],layer:c[5]};if(-1!==h)t[h].references++,t[h].updater(p);else{var m=i(p,r);r.byIndex=a,t.splice(a,0,{identifier:d,updater:m,references:1})}o.push(d)}return o}function i(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,i){var s=r(e=e||[],i=i||{});return function(e){e=e||[];for(var o=0;o<s.length;o++){var a=n(s[o]);t[a].references--}for(var c=r(e,i),l=0;l<s.length;l++){var u=n(s[l]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}s=c}}},7659:e=>{"use strict";var t={};e.exports=function(e,n){var r=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!r)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");r.appendChild(n)}},540:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var r="";n.supports&&(r+="@supports (".concat(n.supports,") {")),n.media&&(r+="@media ".concat(n.media," {"));var i=void 0!==n.layer;i&&(r+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),r+=n.css,i&&(r+="}"),n.media&&(r+="}"),n.supports&&(r+="}");var s=n.sourceMap;s&&"undefined"!=typeof btoa&&(r+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(s))))," */")),t.styleTagTransform(r,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},1407:(e,t,n)=>{"use strict";n.d(t,{R:()=>l});var r=n(4328),i=n(6082),s=n(567),o=n(826),a=n(2738);const c=31;async function l(e,t=!1,n){const a=o.GO.forColumn(e);let l;n??=new Map;const d=a.isHelm()?(0,s.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<d.length;e++)n.has(d[e])||n.set(d[e],`${n.size+1}`);if(a.isHelm())l=await r.functions.call("HELM:getMolFiles",{col:e}),l=function(e,t,n=!1){const r=new Array(e.length);for(let i=0;i<e.length;i++){let s=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(i);s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1,s=l.indexOf("\n",s)+1;const u=parseInt(l.substring(s,s+3)),d=parseInt(l.substring(s+3,s+6));a+=`M V30 COUNTS ${u} ${d} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){s=l.indexOf("\n",s)+1+c,o=l.indexOf(" ",s);const r=l.substring(s,o);a+=n?`M V30 ${e+1} R${t.get(r)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(r)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<d;e++){s=l.indexOf("\n",s)+1;const t=parseInt(l.substring(s,s+3).trim()),n=parseInt(l.substring(s+3,s+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(s+6,s+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",r[i]=a}return r}(l,n,t);else{l=new Array(e.length);for(let r=0;r<e.length;r++){const e=u(a.getSplitted(r),n,t);l[r]=e}}return i.Column.fromStrings("monomericMols",l)}function u(e,t,n=!1){let r="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";r+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,r+="M V30 BEGIN ATOM\n";for(let i=0;i<e.length;i++){const s=e.getCanonical(i);s!==a._S&&(r+=n?`M V30 ${i+1} R${t.get(s)} 0.000 0.000 0 0\n`:`M V30 ${i+1} At 0.000 0.000 0 0 MASS=${t.get(s)}\n`)}r+="M V30 END ATOM\n",r+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)r+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return r+="M V30 END BOND\n",r+="M V30 END CTAB\n",r+="M END",r}},567:(e,t,n)=>{"use strict";n.d(t,{_package:()=>Ct,activityCliffs:()=>Pt,getHelmMonomers:()=>Nt,getMonomerLib:()=>_t,getMonomerLibHelper:()=>Tt,importFasta:()=>$t,sequenceIdentityScoring:()=>Lt,sequenceSimilarityScoring:()=>It,sequenceSpaceTopMenu:()=>xt,toAtomicLevel:()=>Mt});var r,i,s=n(4328),o=n(7389),a=n(6082),c=n(684),l=n(9039);(i=r||(r={})).EUCLIDEAN="EUCLIDEAN",i.MANHATTAN="MANHATTAN";var u=n(1858),d=n(5072),h=n.n(d),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),w=n.n(y),b=n(540),v=n.n(b),A=n(1113),E=n.n(A),C=n(7939),T={};T.styleTagTransform=E(),T.setAttributes=w(),T.insert=g().bind(null,"head"),T.domAPI=m(),T.insertStyleElement=v(),h()(C.A,T),C.A&&C.A.locals&&C.A.locals;var S=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};let _=null,P=null;Promise.resolve(),n(934),n(8903);const x="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;const M=rxjs.operators;n(6295);const $=e=>null==e;function N(e,t,n,r){if(n>e[e.length-1])return;const i=e.findIndex((e=>n<e));e.pop(),e.splice(i,0,n),t.pop(),t.splice(i,0,r)}class L{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,i,s=[{}],o=[1],a=r.EUCLIDEAN){const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,s,o,a):0;i<u&&(console.log(`using threshold ${u}`),i=u),s.forEach(((e,t)=>s[t].threshold=i));const d=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)d[n]=new Promise(((r,u)=>{const d=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=d&&r({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),h[n].postMessage({values:e,startIdx:d,endIdx:p,threshold:i,fnNames:t,opts:s,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,i:t,j:i,distance:s}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),r({i:t,j:i,distance:s,idx:n}))}}));const p=await Promise.all(d),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let w=0;for(const e of p)f.set(e.i,w),g.set(e.j,w),y.set(e.distance,w),w+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,r={}){return await this.calcMultiColumn([e],[t],n,[r],[1])}async getKNN(e,t,n=15,r={}){return await this.multiColumnKNN([e],[t],n,[r],[1])}async getThresholdKNN(e,t,n=.8,r={}){return await this.multiColumnThresholdKnn([e],[t],n,[r],[1])}async multiColumnThresholdKnn(e,t,i=.8,s,o,a=r.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((r,u)=>{const h=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=h&&r({knnDistances:new Array(0),knnIndexes:new Array(0)}),d[n].postMessage({values:e,startIdx:h,endIdx:p,fnNames:t,opts:s,threshold:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),r({knnDistances:t,knnIndexes:i}))}}));const h=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of h)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of h)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnKNN(e,t,i=15,s,o,a=r.EUCLIDEAN){if(e.length!==t.length||e.length!==s.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const c=e[0].length*(e[0].length-1)/2,l=Math.floor(c/this._workerCount),u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((r,u)=>{const h=n*l,p=n===this._workerCount-1?c:(n+1)*l;p<=h&&r({knnDistances:new Array(0),knnIndexes:new Array(0)}),d[n].postMessage({values:e,startIdx:h,endIdx:p,fnNames:t,opts:s,nNeighbours:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),r({knnDistances:t,knnIndexes:i}))}}));const h=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(i).fill(-1)))};for(const t of h)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)N(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,i=[],s,o=r.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,r=Math.floor(n/this._workerCount),c=1e6,l=Math.max(Math.min(n/1e3,c),Math.min(n,c)),u=Math.floor(l/this._workerCount),d=new Array(this._workerCount);for(let c=0;c<this._workerCount;c++)d[c]=new Promise(((l,d)=>{const h=c*r,p=c===this._workerCount-1?n:(c+1)*r;a[c].postMessage({values:e,startIdx:h,endIdx:p,sampleLength:u,fnNames:t,opts:i,weights:s,aggregationMethod:o}),a[c].onmessage=({data:{error:e,distance:t}})=>{a[c].terminate(),e?d(e):l({distance:t})}}));const h=await Promise.all(d),p=h.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of h)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],i,s=r.EUCLIDEAN){try{const r=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,n,i,s);return 1-o[Math.floor(7e7/r*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,r){const i=[],s=[],o=[];let a=0,c=0,l=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=$(e[c])||$(e[l])?1:n(e[c],e[l]);1-t>=r&&(i.push(c),s.push(l),o.push(t)),a++,l++,l===e.length&&(c++,l=c+1)}return{i:new Int32Array(i),j:new Int32Array(s),distance:new Float32Array(o)}}}var I,R,O=n(8774);(R=I||(I={})).none="none",R.bold="bold",R.dashed="dashed";class k{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,r,i=I.none){var s;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=i,this.updateLines(r),this.visibility=null!==(s=r.visibility)&&void 0!==s?s:new O.A(this.lines.from.length),r.visibility||this.visibility.setAll(!0,!1),r.arrowSize&&(this.arrowWidth=r.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,r,i,s,o,a,c,l,u,d,h,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const w=this.sp.dataFrame.filter,b=Math.pow(null!==(r=this.lines.shortLineThreshold)&&void 0!==r?r:5,2);for(let e=0;e<this.lines.from.length;e++)if(w.get(this.lines.from[e])&&w.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,r=this.sp.getMarkerSize(this.lines.to[e])/2,w=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let v=null==w?void 0:w.x,A=null==w?void 0:w.y;const E=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let C=null==E?void 0:E.x,T=null==E?void 0:E.y;const S=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),v&&A&&C&&T&&Math.hypot(C-v,T-A)/S>.01){if(y){const t=(null===(i=this.lines.colors)||void 0===i?void 0:i[e])?null===(s=this.lines.colors)||void 0===s?void 0:s[e]:null!==(o=this.lines.color)&&void 0!==o?o:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(c=this.lines.opacities)||void 0===c?void 0:c[e]:null!==(l=this.lines.opacity)&&void 0!==l?l:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(d=this.lines.widths)||void 0===d?void 0:d[e]:null!==(h=this.lines.width)&&void 0!==h?h:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const w=this.multipleLinesCounts[e];let E=null;if(w){t=this.getLineLength(v,A,C,T);const i=this.getPointOnDistance(v,A,C,T,r,t),s=this.getPointOnDistance(C,T,v,A,n,t);v=i.x,A=i.y,C=s.x,T=s.y,E=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(w,v,A,C,T,e):this.findControlPoint(w,C,T,v,A,e),this.ctx.moveTo(v,A),this.ctx.quadraticCurveTo(E.x,E.y,C,T)}else(!this.lines.skipShortLines||Math.pow(C-v,2)+Math.pow(T-A,2)>b)&&(this.ctx.moveTo(v,A),this.ctx.lineTo(C,T));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(v,A,C,T)),t>this.arrowWidth)){const e=w?null:this.getPointOnDistance(v,A,C,T,r,t),n=w?E.x:v,i=w?E.y:A;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:v,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:A,n,i)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case I.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case I.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,r=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],r=this.lines.to[t]):(n=this.lines.to[t],r=this.lines.from[t]),e[`${n}|${r}`]?(1===e[`${n}|${r}`].length&&(this.multipleLinesCounts[e[`${n}|${r}`][0]]=1,e[`${n}|${r}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${r}`][1]):e[`${n}|${r}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,r=null,i=null;const s=this.sp.dataFrame.filter;for(let o=0;o<this.lines.from.length;o++)if(s.get(this.lines.from[o])&&s.get(this.lines.to[o])&&this.visibility.getBit(o)){const s=this.sp.getMarkerSize(this.lines.from[o])/2,a=this.sp.getMarkerSize(this.lines.to[o])/2,c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[o]),this.yAxisCol.get(this.lines.from[o])),l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[o]),this.yAxisCol.get(this.lines.to[o]));if(this.multipleLinesCounts[o]){const n=this.getLineLength(c.x,c.y,l.x,l.y),r=this.getPointOnDistance(c.x,c.y,l.x,l.y,a,n),u=this.getPointOnDistance(l.x,l.y,null==c?void 0:c.x,null==c?void 0:c.y,s,n),d=this.lines.from[o]>this.lines.to[o]?this.findControlPoint(this.multipleLinesCounts[o],r.x,r.y,u.x,u.y,o):this.findControlPoint(this.multipleLinesCounts[o],u.x,u.y,r.x,r.y,o);i=this.calculateDistToCurveLine(o,e,t,r,u,d)}else i=this.calculateDistToStraightLine(e,t,c,l);(!r&&null!==i&&i<5||r&&null!==i&&i<r)&&(r=i,n=o)}return n}calculateDistToStraightLine(e,t,n,r){const i=Math.min(n.x,r.x),s=Math.max(n.x,r.x),o=Math.min(n.y,r.y),a=Math.max(n.y,r.y);return e>=i-2&&e<=s+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,r):null}distToStraightLineSegment(e,t,n,r){const i=(e,t,n,r)=>Math.pow(e-n,2)+Math.pow(t-r,2),s=i(n.x,n.y,r.x,r.y);if(0==s)return i(e,t,n.x,n.y);let o=((e-n.x)*(r.x-n.x)+(t-n.y)*(r.y-n.y))/s;return o=Math.max(0,Math.min(1,o)),i(e,t,n.x+o*(r.x-n.x),n.y+o*(r.y-n.y))}calculateDistToCurveLine(e,t,n,r,i,s){const o=Math.min(r.x,i.x,s.x),a=Math.max(r.x,i.x,s.x),c=Math.min(r.y,i.y,s.y),l=Math.max(r.y,i.y,s.y);if(t>=o-2&&t<=a+2&&n>=c-2&&n<=l+2){const e=a-o,u=l-c;return this.calculateDistToCurveInRect(t,n,r,s,i,e,u)}return null}calculateDistToCurveInRect(e,t,n,r,i,s,o){const a=Math.floor((s+o)/3),c=1/a,l=new Uint32Array(a),u=new Uint32Array(a),d=new Uint32Array(a);let h=null;const p=new O.A(a);for(let s=0;s<l.length;s++){const o=s*c,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*r.x+Math.pow(o,2)*i.x,p=Math.pow(1-o,2)*n.y+2*o*(1-o)*r.y+Math.pow(o,2)*i.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!h||h>g)&&(h=g),d[s]=Math.max(m,f),l[s]=a,u[s]=p}for(let e=0;e<l.length;e++)d[e]<h&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const r=Math.hypot(l[n]-e,u[n]-t);(!m||m>r)&&(m=r)}return m}getLineLength(e,t,n,r){return Math.sqrt(Math.pow(n-e,2)+Math.pow(r-t,2))}getPointOnDistance(e,t,n,r,i,s){const o=n-i*((n-e)/s),c=r-i*((r-t)/s);return new a.Point(o,c)}findControlPoint(e,t,n,r,i,s){const o=t+(r-t)/2,c=n+(i-n)/2;let l=o-t,u=c-n;const d=Math.sqrt(l*l+u*u);l/=d,u/=d;const h=50*Math.ceil(e/2);return e%2==0?new a.Point(o+h/2*u,c-h/2*l):new a.Point(o-h/2*u,c+h/2*l)}canvasArrow(e,t,n,r,i){const s=Math.atan2(r-t,i-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(s-Math.PI/10),n-this.arrowWidth*Math.cos(s-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(s+Math.PI/10),n-this.arrowWidth*Math.cos(s+Math.PI/10))}}const G="dimensionality-reducer-terminate-event";var H,D,F=n(3629);async function U(e,t,r,i,o,a,c){let l=await async function(e,t,r,i,o,a,c){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==i.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(l,u){const d=new Worker(new URL(n.p+n.u(234),n.b));d.postMessage({columnsData:e,distanceMetrics:t,method:r,options:a,weights:i,aggregationMethod:o});const h=s.events.onCustomEvent(G).subscribe((()=>{try{d?.terminate()}finally{h.unsubscribe()}}));d.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:r}})=>{$(n)||$(r)?(h.unsubscribe(),e?u(e):l(t),setTimeout((()=>d.terminate()),100)):c&&c(n,r,t)}}))}(e,r,t,i,o,a,c);return l=l.map((e=>(0,F.S8)(e))),l}(D=H||(H={})).EUCLIDEAN="EUCLIDEAN",D.MANHATTAN="MANHATTAN";const V={[H.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[H.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Y,B;(B=Y||(Y={})).HAMMING="Hamming",B.EUCLIDEAN="Euclidean",B.MANHATTAN="Manhattan",B.TANIMOTO="Tanimoto",B.LEVENSTEIN="Levenshtein",B.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",B.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",B.SOKAL="Sokal",B.COSINE="Cosine",B.ASYMMETRIC="Asymmetric",B.Difference="Difference",B.OneHot="One-Hot";const W={[Y.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Y.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[Y.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[Y.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Y.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Y.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Y.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Y.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Y.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Y.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Y.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Y.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},j={[Y.HAMMING]:e=>Math.ceil(e/30),[Y.EUCLIDEAN]:e=>Math.ceil(e/30),[Y.MANHATTAN]:e=>Math.ceil(e/30),[Y.TANIMOTO]:e=>Math.ceil(e/60),[Y.SOKAL]:e=>Math.ceil(e/60),[Y.COSINE]:e=>Math.ceil(e/60),[Y.ASYMMETRIC]:e=>Math.ceil(e/60),[Y.LEVENSTEIN]:e=>Math.ceil(e*e/60),[Y.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[Y.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[Y.Difference]:e=>1,[Y.OneHot]:e=>Math.ceil(e/40)},K={STRING:new Set([Y.HAMMING,Y.LEVENSTEIN,Y.NEEDLEMAN_WUNSCH,Y.MONOMER_CHEMICAL_DISTANCE,Y.OneHot]),UINT32ARRAY:new Set([Y.HAMMING,Y.EUCLIDEAN,Y.MANHATTAN,Y.MONOMER_CHEMICAL_DISTANCE,Y.LEVENSTEIN,Y.NEEDLEMAN_WUNSCH,Y.TANIMOTO,Y.COSINE,Y.SOKAL,Y.ASYMMETRIC,Y.OneHot,Y.Difference]),INT32ARRAY:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.OneHot,Y.Difference]),FLOAT32ARRAY:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.Difference]),NUMBER:new Set([Y.EUCLIDEAN,Y.MANHATTAN,Y.Difference]),BITARRAY:new Set([Y.TANIMOTO,Y.COSINE,Y.SOKAL,Y.ASYMMETRIC])};var q=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function Z(e,t,n,r){return e.map(((e,r)=>`\n fn distanceScript${r}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${r}[aIndex];\n let b = computeInfo.data${r}[bIndex];\n let maxDistance: f32 = ${n};\n ${W[e](t[r],r)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${V[r](e.length)}\n }\n \n `}let z=0;const X="cliffsDf",J=new u.Subject,Q="activity_difference",ee="SALI_index",te="similarity",ne="line_index",re=["1_molecule","2_molecule"],ie="filterCliffs";async function se(e,t,r,i,c,l,u,d,h,p,m,f,g,y,w,b,v){z++;const A=l/100;let E,C=!1;const T=f.inputs,$=await f.apply({[T[0].name]:t,[T[1].name]:u,...h.preprocessingFuncArgs??{}});let N=[];if(d===x){const t=await function(e,t,r,i,s,o,a=10,c=!1,l=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let d;return u.postMessage({data:e,threshold:t,weights:r,aggregationMethod:i,distanceFns:s,distanceFnArgs:o,maxIterations:a,useWebGPU:c,inflate:l}),{promise:new Promise(((e,t)=>{d=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{d(null),u.terminate()}catch(e){console.error(e)}}}}([$.entries],l,[1],"MANHATTAN",[u],[$.options??{}],h?.maxIterations??5,h.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),N=[t.embedX,t.embedY]}else N=await U([$.entries],d,[u],[1],"MANHATTAN",{...h,distanceFnArgs:[$.options??{}]});if(N.length!==r.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<N.length;++t)e.columns.addNewFloat(r[t]).init((e=>N[t][e]));let R=null;if(h.useWebGPU)try{R=await function(e,t=.8,n,r,i,s){return q(this,void 0,void 0,(function*(){const o=yield function(){return S(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==_))return null;let e=!1;if(P&&(P.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!P||e){const e=1e9,t=_.limits,n=t.maxBufferSize,r=t.maxStorageBufferBindingSize;try{return P=yield _.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(r,e)}}),P}catch(e){return console.error("Failed to create device with required limits",e),P=yield _.requestDevice(),P}}return P}))}();if(!o)return null;const a=Object.values(Y);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(H).includes(r))throw new Error("Invalid aggregation function provided: "+r);const c=1-t;if(s.length!==e.length||s.length!==n.length||s.length!==i.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const l=e.length,u=e[0].length,d=e.map(((e,t)=>function(e,t=Y.HAMMING,n,r={gapOpenPenalty:1,gapExtensionPenalty:.6}){var i,s;let o=null;const a=e.some((e=>"string"==typeof e))?(o="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(o="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(o="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(o="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(o="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(o="INT32ARRAY",e):void 0;if(!a||!o)throw new Error("Invalid entry type, could not determine entry type from input list");const c=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",l=new Uint32Array(a.map((e=>e.length)));if(!K[o]||!K[o].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${o}'`);const u=l.reduce(((e,t)=>Math.max(e,t)),0),d=j[t](u),h="INT32ARRAY"===c?Int32Array:"FLOAT32ARRAY"===c?Float32Array:Uint32Array,p=new h(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(t===Y.NEEDLEMAN_WUNSCH||t===Y.MONOMER_CHEMICAL_DISTANCE){let e=r.scoringMatrix&&r.alphabetIndexes?Object.keys(r.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!r.alphabetIndexes||!r.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);r.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),r.alphabetIndexes={};for(let e=0;e<r.scoringMatrix.length;e++)r.scoringMatrix[e][e]=1,r.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),o=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)o[t][t]=1;const a=r.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(o[e.charCodeAt(0)][t.charCodeAt(0)]=r.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(i=r.gapOpenPenalty)&&void 0!==i?i:1,y[1]=null!==(s=r.gapExtensionPenalty)&&void 0!==s?s:.6;let c=2;for(let e=0;e<o.length;e++)y.set(o[e],c),c+=o[e].length;m=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===Y.Difference){if(!r.range||"number"!=typeof r.range||r.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);r.range=t-e}r.range<=0&&(r.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([r.range]),m=`\n range${n}: f32`}const w=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",b=`data${n}: array<array<${w}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:l,complexity:d,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:o,dataTypeWGSL:w,dataStructWgsl:b,EncodedArrayConstructor:h}}(e,n[t],t,s[t])));if(0===l)throw new Error("No columns provided. Please provide at least one column of data.");1===l&&(r=H.MANHATTAN);let h=d.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;h&&""!=h.trim()||(p=!0,h="\ndummy: f32\n");const m=d.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(l*u);d.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,w=d.reduce(((e,t)=>e+t.complexity),0),b=Math.ceil(6e3/w),v=Math.ceil(Math.sqrt(Math.ceil(100))),A=10*v,E=u*(u-1)/2,C=Math.ceil(E/g),T=o.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${C} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${l}>,\n // the weights for each entry\n weights: array<f32, ${l}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${h}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${A} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${b}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${c}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${Z(n,d.map((e=>e.maxEntryLen)),c,r)}\n\n\n `}),x=o.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:T,entryPoint:"calcSparseMatrix"}}),M=new Uint32Array(g),$=new Uint32Array(g),N=new Uint32Array(g),L=new Uint32Array(g),I=Math.floor(E/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?E-1:(e+1)*I,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),r=t-u*n+Math.floor((n+1)*(n+2)/2);M[e]=O,$[e]=R,N[e]=r,L[e]=n,R=n,O=r}console.timeEnd("GPUthreadStarts");const k=4e4+u*l+l+d.reduce(((e,t)=>e+t.sourceArraySize),0),G=d.reduce(((e,t)=>e+t.suppInfoSize),0),D=1e6,F=k*Uint32Array.BYTES_PER_ELEMENT;let U=F;const V=15&F;0!==V&&(U+=16-V);const B=o.createBuffer({label:"compute info buffer",size:U,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),W=B.getMappedRange();let q=0;new Uint32Array(W,q,g).set(M),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set($),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set(N),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,g).set(L),q+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(W,q,f.length).set(f),q+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(W,q,l).set(i),q+=l*Float32Array.BYTES_PER_ELEMENT;for(const e of d){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(W,q,n).set(e.flatSourceArray),q+=n*t.BYTES_PER_ELEMENT}B.unmap();const z=G*Uint32Array.BYTES_PER_ELEMENT;let X=z;const J=15&z;0!==J&&(X+=16-J),X=Math.max(X,16);const Q=o.createBuffer({label:"supp info buffer",size:X,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),ee=Q.getMappedRange();let te=0;for(const e of d)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(ee,te,e.suppInfoBuffer.length).set(e.suppInfoBuffer),te+=e.suppInfoBuffer.byteLength);0===te&&new Uint32Array(ee,0,4).set([1,1,1,1]),Q.unmap();const ne=302e4*Uint32Array.BYTES_PER_ELEMENT;let re=ne;const ie=15&ne;0!==ie&&(re+=16-ie);const se=o.createBuffer({label:"results buffer",size:re,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),oe=o.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:x.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:B}},{binding:1,resource:{buffer:Q}},{binding:2,resource:{buffer:se}}]}),ae=o.createBuffer({label:"results out buffer",size:se.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),ce=[],le=[],ue=[];let de=!1;for(;!de;){const e=o.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(x),t.setBindGroup(0,oe),t.dispatchWorkgroups(v,v),t.end(),e.copyBufferToBuffer(se,0,ae,0,ae.size);const n=e.finish();o.queue.submit([n]),yield o.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const r=ae.getMappedRange();let i=0;const s=new Uint32Array(r,i,D);i+=D*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(r,i,D);i+=D*Uint32Array.BYTES_PER_ELEMENT;const c=new Float32Array(r,i,D);i+=D*Float32Array.BYTES_PER_ELEMENT;const l=new Uint32Array(r,i,g);i+=g*Uint32Array.BYTES_PER_ELEMENT,de=new Uint32Array(r,i,g).every((e=>1===e));const u=l.reduce(((e,t)=>e+t),0),d=new Uint32Array(u),h=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<l.length;e++){const t=l[e];0!==t&&(d.set(s.subarray(e*y,e*y+t),m),h.set(a.subarray(e*y,e*y+t),m),p.set(c.subarray(e*y,e*y+t),m),m+=t)}ce.push(d),le.push(h),ue.push(p),ae.unmap()}const he=ce.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(he),me=new Uint32Array(he),fe=new Float32Array(he);let ge=0;for(let e=0;e<ce.length;e++)pe.set(ce[e],ge),me.set(le[e],ge),fe.set(ue[e],ge),ge+=ce[e].length;return B.destroy(),Q.destroy(),se.destroy(),ae.destroy(),{i:pe,j:me,distance:fe}}))}([$.entries],A,[u],H.MANHATTAN,[1],[$.options??{}])}catch(e){console.error(e)}R||(h.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),R=await(new L).calc($.entries,u,A,$.options));const O=await async function(e,t){const n=e.distance.map(((n,r)=>{const i=Math.abs(t.get(e.i[r])-t.get(e.j[r]));return 0!=n?i/n:1/0})),r=e.distance.map((e=>1-e)),i=e.i,s=e.j,o=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{o.set(e.i[n],!0),o.set(e.j[n],!0)})),{simVals:r,saliVals:n,n1:i,n2:s,cliffsBitSet:o}}(R,c),G=function(e,t,n,r,i,s,o){const c=new Array(e).fill(0);for(let e=0;e!=r.length;++e)n[e]!=1/0&&(o.get(r[e])>o.get(i[e])?c[r[e]]+=n[e]:c[i[e]]+=n[e]);return a.Column.fromList("double",t,c)}(t.length,`sali_${r[0].substring(r[0].lastIndexOf("_"))}`,O.saliVals,O.n1,O.n2,0,c);e.columns.add(G);const D=O.cliffsBitSet,F=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}(O.saliVals),V=.8/(F.max-F.min),B=v?s.shell.view("Browse").preview:s.shell.getTableView(e.name),W=B.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:r[0],yColumnName:r[1],size:G.name,color:c.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:i}),se=function(e,t,n,r,i,s,o,c){const l={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)l.from[n]=t.n1[n],l.to[n]=t.n2[n],l.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-o.min)*c,l.colors[n]=e.selection.get(l.from[n])&&e.selection.get(l.to[n])?"255,255,0":"0,128,0",l.widths[n]=1;const u=a.DataFrame.create(l.from.length);return re.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?l.from[e]:l.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),s),u.col(e).semType=i})),u.columns.addNewFloat(Q).init((e=>Math.abs(r.get(l.from[e])-r.get(l.to[e])))),u.columns.addNewInt(ne).init((e=>e)),u.columns.addNewFloat(ee).init((e=>t.saliVals[e])),u.columns.addNewFloat(te).init((e=>t.simVals[e])),u.name=`${X}${z}`,{lines:l,linesDf:u}}(e,O,t,c,p,m,F,V);se.lines.skipMultiLineCalculation=!0,se.linesDf.col(ee).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const oe=new k(W,r[0],r[1],se.lines,I.none),ae=w?w(se.linesDf,re).sort([ee],[!1]):se.linesDf.plot.grid().sort([ee],[!1]);ae.col(ne)&&(ae.col(ne).visible=!1),e.temp[".cliffsDfGrid"]=ae;const ce=o.button(`${se.linesDf.rowCount} cliffs`,(()=>{v&&B.addViewer(ae),B.dockManager.dock(ae,"down",null,"Activity cliffs",b??.2)}));ce.classList.add("scatter_plot_link","cliffs_grid"),W.root.append(ce);const le=o.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(W.dataFrame.setTag(ie,r[0]),e.filter.and(D),J.next(r[0])):(W.dataFrame.setTag(ie,""),e.filter.setAll(!0),J.next(""))}});le.root.classList.add("scatter_plot_link","show_only_cliffs"),W.root.append(le.root),J.subscribe((e=>{le.enabled=""===e||e===r[0]}));let ue=!1;W.onEvent("d4-before-draw-scene").subscribe((t=>{ue?ue=!1:le.value&&(setTimeout((()=>{e.filter.and(D)}),100),ue=!0)}));const de=s.events.onViewerClosed.subscribe((e=>{e.args.viewer===W&&(B.dockManager.close(ae.root),de.unsubscribe(),B.subs=B.subs.filter((e=>e!==de)))}));return B.subs.push(de),se.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<se.linesDf.rowCount;e++)se.lines.widths[e]=e===se.linesDf.currentRowIdx?3:1;oe.linesToRender=se.lines;const n=se.linesDf.currentCol&&se.linesDf.currentCol.name===re[1]?se.lines.to:se.lines.from,i=-1!==se.linesDf.currentRowIdx?se.linesDf.currentRowIdx:null;if(W.dataFrame.currentRowIdx=i?n[i]:-1,null!==i){const n=se.linesDf.currentRowIdx;oe.currentLineId=n;const{zoomLeft:a,zoomRight:l,zoomTop:u,zoomBottom:d}=function(e,t,n,r,i,s){const o=Math.abs(n-i),a=Math.abs(r-s),c=e/o,l=t/a,u=Math.min(c,l),d=e/u*5,h=t/u*5,p=(n<i?n:i)+o/2-d/2,m=(r>s?r:s)-a/2+h/2;return{zoomLeft:p,zoomRight:p+d,zoomTop:m,zoomBottom:m-h}}(W.viewport.width,W.viewport.height,W.dataFrame.get(r[0],se.lines.from[n]),W.dataFrame.get(r[1],se.lines.from[n]),W.dataFrame.get(r[0],se.lines.to[n]),W.dataFrame.get(r[1],se.lines.to[n]));W.zoom(a,u,l,d),le.value?e.filter.and(D):!0===le.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,r,i,a,c,l,u){const d=t.getPane("Cliff Details");o.empty(d.root);const h=u({points:[n,r],lineId:i,df:e,seqCol:a,activityCol:c,sali:l});d.root.append(h),setTimeout((()=>{s.shell.o=t.root}),500)}(e,E,se.lines.from[i],se.lines.to[i],i,t,c,se.linesDf.get(ee,i),y);const n=W.dataFrame.getSortedOrder(B.grid.sortByColumns,B.grid.sortTypes);B.grid.scrollToCell(t.name,n.indexOf(W.dataFrame.currentRowIdx))}),1e3)}})),se.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<se.linesDf.rowCount;e++){const n=se.linesDf.selection.get(e);n&&(t.set(se.lines.from[e],!0),t.set(se.lines.to[e],!0)),se.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),oe.linesToRender=se.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(C?C=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<se.lines.colors.length;e++)se.lines.colors[e]="0,128,0";oe.linesToRender=se.lines})(ae.dataFrame))})),oe.lineClicked.subscribe((t=>{if(C=!0,oe.currentLineId=t.id,-1!==t.id){const n=se.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),se.linesDf.selection.copyFrom(n)):(se.linesDf.currentRowIdx!==t.id&&(se.linesDf.currentRowIdx=t.id,e.currentRowIdx=se.lines.from[t.id]),se.linesDf.selection.copyFrom(n));const r=se.linesDf.getSortedOrder(ae.sortByColumns,ae.sortTypes);ae.scrollToCell(re[0],r.indexOf(t.id))}),500)}})),oe.lineHover.pipe((0,M.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(g({lineId:n.id,points:[se.lines.from[n.id],se.lines.to[n.id]],df:e,seqCol:t,activityCol:c}),n.x,n.y)})),W.addProperty("similarityLimit","double",A),E=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),s.shell.o=e.root,e}(),W}var oe,ae=n(2003),ce=n(826),le=n(3516),ue=n(6718),de=n(2738),he=n(3077);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(oe||(oe={}));var pe,me,fe,ge=n(9192),ye=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function we(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function be(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(pe||(pe={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(me||(me={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(fe||(fe={})),Object.prototype.toString,n(6873);var ve=n(4356),Ae=(n(6717),n(4870),n(1991)),Ee=n.n(Ae),Ce=n(9322);const Te="#808080",Se="rgb(0,0,0)",_e=Ce.zS;var Pe,xe;(Pe||(Pe={})).maxMonomerLength=".mm.cellRenderer.maxMonomerLength",function(e){e.MSA="MSA",e.classic="classic"}(xe||(xe={}));const Me=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=xe.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function $e(e,t,n,r,i,s,o){var a,c,l;const u=Object.assign(Object.assign({},Me),o);o.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let d=t.substring(0),h=u.last?"":u.separator;u.drawStyle===xe.MSA&&(h="");let p=!0,m=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(p=u.gridCell.cell.column.temp["color-code"]??!0,m=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];m&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=d==e?.3:u.transparencyRate),m&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=d!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(d=_e(d,u.maxLengthOfMonomer));const g=d+h;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));let w=u.monomerTextSizeMap[d].width;const b=s/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));const v=u.monomerTextSizeMap[h].width;function A(t,i){const s=p?u.color:Se;e.fillStyle=s,e.globalAlpha=u.transparencyRate,u.drawStyle===xe.classic&&(e.fillText(d,n+t,r+b),e.fillStyle=Te,e.fillText(h,n+i,r+b)),u.drawStyle===xe.MSA&&e.fillText(d,n+t,r+b)}y=y.width,u.drawStyle===xe.MSA&&(w=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const E=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>i)return A(E,E+w),n+E+w+v;{const e=(i-y)/2;return A(e,e+w),n+E+e+w}}n(6882);var Ne=n(4152);function Le(e){const t=!Ee().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],r=t?"":" ";for(const[t,i]of Ee().enumerate(e)){let s=t;i<e.length&&(s+=`${t?"":"-"}${r}`),n.push(s)}return[n,t]}function Ie(e,t,n,r,i,s,o){const a=document.createElement("canvas"),c=a.getContext("2d");c.font="12px monospace";const l=c.measureText(Le([e]).join("")).width,u=c.measureText(Le([t]).join("")).width,d=Math.max(l,u);return a.height=o,a.width=d+4,c.font="12px monospace",c.textBaseline="top",$e(c,e,0,i-s,d,o,{color:n,pivot:0,left:!0}),$e(c,t,0,i+s,d,o,{color:r,pivot:0,left:!0}),a}ae.YI.DNA,ae.YI.RNA,ae.YI.PT,ae.YI.UN,n(6642),n(4139),ae.zS,a.GridCellRenderer,a.GridCellRenderer;var Re,Oe,ke,Ge=n(8070),He=n(4326);function De(e){const t=o.divH([],{style:{gap:"10px"}}),n=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const r=o.divText(e.activityCol.get(n).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(n)),r]))})),t}function Fe(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,r)=>{n[r]=e.activityCol.get(t)}));const r={},i=ce.GO.forColumn(e.seqCol),s=function(e,t,n,r){const i=document.createElement("canvas"),s=i.getContext("2d");return i.height=30,function(e,t,n,r,i,s,o,a,c,l){if(s.length!==o.length){const e=function(e,t){let n=0,r=0;const i=e.length>t.length?e:t,s=e.length>t.length?t:e;for(let e=0;e<s.length;e++)i[e]===s[e]&&n++;const o=i.length-s.length;for(let e=i.length-1;e>o;e--)i[e]===s[e-o]&&r++;const a=new Array(Math.abs(e.length-t.length)).fill(ce.b9[ae.Hi.FASTA]);function c(e){return n>r?e.concat(a):a.concat(e)}return e.length>t.length?t=c(Ee()(t).toArray()):e=c(Ee()(e).toArray()),{subParts1:e,subParts2:t}}(s,o);s=e.subParts1,o=e.subParts2}const u=e.measureText(Le(s).join("")),d=e.measureText(Le(o).join("")),h=Math.max(u.width,d.width);c&&(r=h+4*s.length,e.canvas.width=h+4*s.length);let p=Math.max(t,t+(r-(h+4*s.length))/2)+5;const m=Math.max(n,n+(i-28)/2);e.save(),e.beginPath(),e.rect(t,n,c?h+4*s.length:r,i),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Ne.oT.Color;"HELM"!==a&&(f=(0,ae.ny)(a.substring(a.length-2)));for(let t=0;t<s.length;t++){const n=s[t],a=o[t],c=f.get(n);if(n!=a){const s=f.get(a),o=$e(e,n,p,m-7,r,i,{color:c,pivot:0,left:!0}),u=$e(e,a,p,m+7,r,i,{color:s,pivot:0,left:!0});p=Math.max(u,o),l&&(l[t]=Ie(n,a,c,s,m,7,i))}else p=$e(e,n,p,m,r,i,{color:c,pivot:0,left:!0,transparencyRate:.5});p+=4}e.restore()}(s,0,0,0,30,Ee()(e.canonicals).toArray(),Ee()(t.canonicals).toArray(),n,!0,r),i}(i.getSplitted(e.points[0]),i.getSplitted(e.points[1]),i.units,r);return t.append(o.div(s,{style:{width:"300px",overflow:"scroll"}})),t.append(function(e){const t=o.div();if(Object.keys(e).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}(r)),t.append(Ue("Activity delta",Math.abs(n[0]-n[1]))),t.append(Ue("Cliff",e.sali)),t}function Ue(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function Ve(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(ae.gp.separator,e.col(t[0]).getTag(ae.gp.separator)),e.columns.add(n);const r=e.plot.grid();return r.col(t[0]).visible=!1,r.col(t[1]).visible=!1,r}!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Re||(Re={})),new class{constructor(){this.regionTypes=[Re.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=He.fH.Entropy,this.filterSource=He.Fo.filterSource}},n(7602),n(8047),function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(Oe||(Oe={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(ke||(ke={})),a.JsViewer,n(6863),n(2780),n(8115),a.JsViewer,n(1407);var Ye,Be,We=n(439);ce.b9[We.Hi.FASTA],n(5433),n(3890),n(1687),function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Ye||(Ye={}));class je{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const r=this.isWhitespace(n)?t:t-1;for(let e=0;e<r;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToAtomType(n),t[r]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let r=this.getAtomBlockIdx();for(let i=0;i<this.atomCount;i++){r=this.shiftIdxToXColumn(r);for(const s of[e,t,n])s[i]=this.parseFloatValue(r),r=this.getNextColumnIdx(r);r=this.getNextLineIdx(r)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const r=new Uint16Array(2);r[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),r[1]=this.parseIntValue(t),e[n]=r,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let r=0;r<e;r++)n=this.shiftIdxToBondType(n),t[r]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Ke extends je{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let r=0;r<t;r++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class qe extends Ke{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Ye.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,r]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,r)}}));const n=t.map(((e,t)=>{if(e.startsWith(Ye.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),r=n.map((e=>t[e])),i=n.map((e=>t[e+1]));r.forEach(((t,n)=>{const r=parseInt(t.split(/\s+/)[1])-1,s=parseInt(i[n].substring(1));if(e.has(s))throw new Error(`R group ${s} is already in the map`);e.set(s,r)}));const s=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==s.length)throw new Error(`Unaccounted R group indices: ${s}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Ye.TYPE)&&-1!==e.indexOf(Ye.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Ye.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Ye.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Ye.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Ye.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Ye.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Ye.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ze extends Ke{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const r=t.match(/RGROUPS=\(([\d\s]+)\)/);if(r){const t=r[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const i=t[1];if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class ze{constructor(){}static getInstance(e){if(ze.isMolfileV2K(e))return new qe(e);if(ze.isMolfileV3K(e))return new Ze(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return qe.isValidMolfile(e)}static isMolfileV3K(e){return Ze.isValidMolfile(e)}}!function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(Be||(Be={}));var Xe=n(5488),Je={};Je.styleTagTransform=E(),Je.setAttributes=w(),Je.insert=g().bind(null,"head"),Je.domAPI=m(),Je.insertStyleElement=v(),h()(Xe.A,Je),Xe.A&&Xe.A.locals&&Xe.A.locals;class Qe{source;error;_monomers={};_onChanged=new u.Subject;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){this.source=t,this.error=n,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let r=t;return t===ce.b9[ae.Hi.HELM]?r="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(r="Any"),n[t]={symbol:t,name:r,molfile:"",author:"MISSING",id:-1,rgroups:Ee().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let r=null;if(e){const t=this._monomers[e];r=t?t[n]:null}else{Ct.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(r=t[n],r)break}return r}_monomerSets=null;getMonomerSet(e){const t=function(e){let t;switch(e){case Be.BASE:case Be.SUGAR:case Be.LINKER:case Be.NUCLEOTIDE:case"nucleotide":t="RNA";break;case Be.AA:t="PEPTIDE";break;case Be.CHEM:t="CHEM";break;case Be.BLOB:t="BLOB";break;default:t="PEPTIDE",console.warn(`Unexpected HelmType '${e}'`)}return t}(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let r=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return r=r.filter((e=>null!==e)),0===r.length?[]:(r=r.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var r;return r=ze.getInstance(t.molfile).atomTypes,r.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),r.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateLibInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={}),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,ve.ub)().then((e=>{this.assignDuplicatePreferances(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferances(e){let t=!0;for(const n in this.duplicateMonomers)for(const r in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[r]){const i=e.duplicateMonomerPreferences[n][r],s=this.duplicateMonomers[n][r].find((e=>e.lib?.source===i));s?this._monomers[n][r]=s:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,r]of Ee().enumerate(e))t[r]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=o.div([],{classes:"ui-form ui-tooltip"}),r=this.getMonomer(e,t);if(r){const e=r.symbol;r.name,n.append(o.divH([o.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),o.div([r.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let i;i=r.molfile?s.chem.svgMol(r.molfile,void 0,void 0,t):r.smiles?o.divV([s.chem.svgMol(r.smiles,void 0,void 0,t),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),n.append(o.div(i,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(o.divText(r.lib?.source??"Missed in libraries"))}else n.append(o.divV([o.divText(`Monomer '${t}' of type '${e}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}class et{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,r,i){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=r,this.monomerLinks=i;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,ge.AP)(e);this.error=t,this.monomers=[]}}}class tt{description;placeholders;source;error;constructor(e,t,n=void 0,r=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=r}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var nt=n(7433),rt=n.n(nt),it=n(1913),st=n.n(it);class ot{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(rt())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});st()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const r=new Set;for(const i of e){const e=i.symbol??i.id??i.name??"#N/A";if(n=this.validateMonomerSchema(i),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,i,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const s=`${i.polymerType??""}-${e}`;r.has(s)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),r.add(s)}return n}}class at{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,r){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=r,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++at.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const r=await s.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),i=JSON.parse(r),o=new ot(i);return new at(o,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await s.dapi.files.exists(ve.so+`${t}`))return void s.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await s.dapi.files.writeAsText(ve.so+`${t}`,e),await this.updateValidLibList(),await s.dapi.files.exists(ve.so+`${t}`)?s.shell.info(`Added ${t} HELM library`):s.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),s.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await s.dapi.files.delete(ve.so+`${e}`),await this.updateValidLibList(),s.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await s.dapi.files.exists(ve.so+`${e}`)?s.shell.error(`Failed to delete ${e} library`):s.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const r=new a.FileSource(e),i=await r.readAsText(t);n=JSON.parse(i);const s={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(s[t]={},o.push(t)),s[t][n]=e})),new Qe(s,t)}async loadSetFromFile(e,t,n){let r={};const i=new a.FileSource(t),s=await i.readAsText(n);r=JSON.parse(s);const o=r.description,c=Object.entries(r.placeholders).map((([t,n])=>{const r=t,i=n.polymerType,s=n.monomerType,o=n.set;return new et(e,r,i,s,o)}));return new tt(o,c)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await s.dapi.files.readAsText(ve.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const r=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(r)&&(this.eventManager.changeValidLibPathList(r),this.libHelper.loadMonomerLib(!0)),r.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${r}`),t.length>0){const e=`Invalid monomer library files in ${ve.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Ct.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Ct.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Ct.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await s.dapi.files.readAsText(ve.Es+`${e}`):t.push(e);const r=n.filter((e=>!t.includes(e)));this.setListHasChanged(r)&&(this.eventManager.changeValidSetPathList(r),this.libHelper.loadMonomerSets(!0)),Ct.logger.debug(`${e}, OUT`)})),Ct.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(ve.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ve.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await s.dapi.files.list(ve.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring(ve.Es.length)))}}class ct{constructor(){}static _instance;static getInstance(){return ct._instance||(ct._instance=new ct),ct._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,M.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class lt{logger;_monomerLib=new Qe({},"MAIN");_monomerSets=new tt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Ge.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++lt.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return lt.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferances(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await at.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],r]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,ve.ub)()]),i=t.filter((e=>{const t=!r.exclude.includes(e),n=0===r.explicit.length||r.explicit.includes(e);return t&&n}));let s=0;const o=i.length,[a]=await Promise.all([Promise.all(i.map((e=>this.readLibrary(ve.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Qe({},e,n)})).finally((()=>{n.update(Math.round(100*++s/o),`Loading monomers ${s}/${o}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let r=0;const i=n.length,[s]=await Promise.all([Promise.all(n.map((t=>this.readSet(ve.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new tt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++r/i),`Loading monomers ${r}/${i}`)})))))]);this._monomerSets.updateSets(s)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;s.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,ve.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,ve.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new lt(Ct.logger);return e._eventManager=ct.getInstance(),e})()),e}}n(1757);var ut=n(3017),dt={};dt.styleTagTransform=E(),dt.setAttributes=w(),dt.insert=g().bind(null,"head"),dt.domAPI=m(),dt.insertStyleElement=v(),h()(ut.A,dt),ut.A&&ut.A.locals&&ut.A.locals,n(3151);new O.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),new O.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),new O.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),new O.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),new O.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048);new O.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),new O.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),new O.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),new O.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048);var ht,pt=n(857),mt={};mt.styleTagTransform=E(),mt.setAttributes=w(),mt.insert=g().bind(null,"head"),mt.domAPI=m(),mt.insertStyleElement=v(),h()(pt.A,mt),pt.A&&pt.A.locals&&pt.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(ht||(ht={})),ht.MONOMER,a.COLUMN_TYPE.STRING,ht.SYMBOL,a.COLUMN_TYPE.STRING,ht.NAME,a.COLUMN_TYPE.STRING,ht.R_GROUPS,a.COLUMN_TYPE.STRING,ht.MONOMER_TYPE,a.COLUMN_TYPE.STRING,ht.POLYMER_TYPE,a.COLUMN_TYPE.STRING,ht.NATURAL_ANALOG,a.COLUMN_TYPE.STRING,ht.AUTHOR,a.COLUMN_TYPE.STRING,ht.CREATE_DATE,a.COLUMN_TYPE.DATE_TIME,ht.ID,a.COLUMN_TYPE.INT,ht.META,a.COLUMN_TYPE.STRING,ht.SOURCE,a.COLUMN_TYPE.STRING;var ft,gt=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};class yt{constructor(e,t,n=!1,r){var i;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>gt(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>gt(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>gt(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(i=null==r?void 0:r.autoStartFirstStep)&&void 0!==i&&i,this._progress.max=0,this._progress.value=1,yt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=o.iconFA("clock");this._isAutomatic||0===t&&(n=o.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const r=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),i=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),s=o.divH([n,r],"grok-tutorial-entry");this._activity.append(s,i)}}_initRoot(){var e,t,n;s.shell.windows.showContextPanel=!0,s.shell.windows.showHelp=!1;const r=s.shell.isInDemo?Array.from(s.shell.view("Browse").dockManager.rootNode.children)[0]:Array.from(s.shell.dockManager.rootNode.children)[0];this._node=s.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,r,""),(null===(t=null===(e=r.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=r.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return gt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],r=this._activity.getElementsByClassName("grok-icon")[this._currentStep],i=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];r.className="grok-icon far fa-spinner-third fa-spin",i.classList.remove("hidden"),i.classList.add("visible");const c=n,l=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{yield this._steps[this._currentStep].func()}catch(e){s.shell.isInDemo=!1,console.error(e)}this._scrollTo(this._root,c.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,r,l),yield(0,Ge.cb)(l));const u=o.iconFA("check");if(r.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}if(s.shell.isInDemo){const e=s.shell.view("Browse");(null==e?void 0:e.preview)instanceof a.TableView&&(yield s.data.detectSemanticTypes(e.preview.dataFrame))}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return gt(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return gt(this,void 0,void 0,(function*(){const r=o.div([],"demo-script-countdown");t.classList.add("hidden");let i=n/1e3;const s=this._createSVGIndicator(i);r.append(s),e.prepend(r);const a=setInterval((()=>{i--,0===i&&(clearInterval(a),r.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return gt(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return gt(this,void 0,void 0,(function*(){s.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){s.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,yt.currentObject=null,s.shell.isInDemo=!1}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return gt(this,void 0,void 0,(function*(){this._initRoot(),s.shell.newView(this.name),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}yt.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(ft||(ft={})),n(5437);var wt=n(966);n(608),n(1619),n(5785),new class{tooltipHandlerTemp="tooltip-handler.Monomer"},a.GridCellRenderer;class bt{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}Map;class vt extends a.Package{_properties;_rdKitModule;get rdKitModule(){return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new bt(super.logger,e.debug)}completeInit(e){this._rdKitModule=e,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,ge.AP)(e);s.shell.error(t),this.logger.error(t,void 0,n)}}n(2174),a.Widget,a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),["1","1A","1C","2","4","4A","4B","5","6"].join(ae.z1);var At=n(8754);async function Et(e,t,n,r){const i=await async function(e,t,n,r){const i=(0,he.R)(t),s=ce.GO.forColumn(t).getNewColumnFromList("ref",[n]),o=ce.GO.forColumn(s).getSplitted(0),c=r===oe.IDENTITY?function(e,t){const n=t.columns.length,r=new Array(n),i=new Array(n),s=new Array(n);for(let o=0;o<n;++o){const n=t.columns.byIndex(o);r[o]=n.getRawData(),i[o]=n.categories.indexOf("");const a=o<e.length?e.getOriginal(o):de._S;s[o]=n.categories.indexOf(a)}const o=a.Column.float("Identity",t.rowCount),c=o.getRawData();for(let n=0;n<t.rowCount;++n){c[n]=0;for(let t=0;t<e.length;++t)(r[t]?r[t][n]:0)===s[t]&&++c[n];c[n]/=e.length}return o}(o,i):r===oe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,ue.uL)(n,e)}(o,i):null;if(null===c)throw new Error(`In bio library: Unknown sequence scoring method: ${r}`);return c.name=e.columns.getUnusedName(c.name),e.columns.add(c),c}(e,t,n,r);for(let e=0;e<i.length;e++)t.isNone(e)&&i.set(e,null,!1);return i}Ce.Mu,n(8312),n(9124),OCL,n(6956);const Ct=new vt;async function Tt(){return await lt.getInstance()}let St=null;function _t(){return St}async function Pt(e,t,n,r,i,u,d,h,p){if(!(0,wt.V)(t,"Activity Cliffs"))return;const m=we(e),f={units:t.meta.units,aligned:t.getTag(ae.gp.aligned),separator:t.getTag(ae.gp.separator),alphabet:t.getTag(ae.gp.alphabet)},g=u,y=t,w=async()=>await se(e,y,m,"Activity cliffs",n,r,g,i,{...h??{}},a.SEMTYPE.MACROMOLECULE,f,d,De,Fe,Ve,void 0,p),b=i===l.c.UMAP?2e5:2e4,v=i===l.c.UMAP?5e3:2e3;if(e.rowCount>b)return void s.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${b}`);const A=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>v&&!h?.[c.vb]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{w().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():w().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,ge.AP)(e);throw Ct.logger.error(t,void 0,n),e})).finally((()=>{A.close()}))}async function xt(e,t,r,i,l,u,d,h,p){const m=p?s.shell.view("Browse").preview:s.shell.tv.dataFrame==e?s.shell.tv:void 0;if((0,wt.V)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),d??={},await async function(e,t,r,i,l,u,d,h=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={}){const w={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==i.length||t.length!==u.length||t.length!==l.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const b=h?f.tableView??s.shell.tableView(e.name)??s.shell.addTableView(e):null,v=async()=>{const v=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let A;try{const E=we(e);function C(n,i,s){let l=null,u=null;e.columns.names().includes(E[0])?(l=e.columns.byName(E[0]),u=e.columns.byName(E[1])):(l=e.columns.add(a.Column.float(E[0],e.rowCount)),u=e.columns.add(a.Column.float(E[1],e.rowCount)),h&&!A&&(A=b.scatterPlot({...w,x:E[0],y:E[1],title:f.scatterPlotName??be(t,r)}))),f[c.YP]&&(A?.root&&o.setUpdateIndicator(A.root,!1),l.init((e=>s[0]?s[0][e]:void 0)),u.init((e=>s[1]?s[1][e]:void 0)));const d=n/i*100;v.update(d,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${d.toFixed(0)}%`)}async function T(){e.columns.add(a.Column.float(E[0],e.rowCount)),e.columns.add(a.Column.float(E[1],e.rowCount));let n=null;h&&(A=b.scatterPlot({...w,x:E[0],y:E[1],title:f.scatterPlotName??be(t,r)}),o.setUpdateIndicator(A.root,!0));const p=s.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&A?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===A?.getOptions()?.look?.title&&(s.events.fireCustomEvent(G,{}),p.unsubscribe(),n?.(),v.close())})),g=new Promise((async(e,s)=>{try{n=e;const s=[];for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const r=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:c}=await n.apply({[r]:t[e],[o]:i[e],...m.preprocessingFuncArgs[e]??{}});s.push({entries:a,options:c}),m.distanceFnArgs.push(c)}else{const n=t[e].toList(),r={};s.push({entries:n,options:r}),m.distanceFnArgs.push(r)}}e(await U(s.map((e=>e.entries)),r,i,l,d,m,f[c.vb]?void 0:C))}catch(e){s(e)}})),y=await g;return v.close(),p.unsubscribe(),y}const S=await T();if(p&&S){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const P=await function(e,t,r,i){return ye(this,void 0,void 0,(function*(){return new Promise((function(s,o){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:i,epsilon:r}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):s(t)}}))}))}(S[0],S[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),x=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(x).init((e=>P[e].toString())),A&&(A.props.colorColumnName=x)}catch(M){s.shell.error("Clustering embeddings failed"),console.error(M)}finally{_.close()}}if(S){const $=e.columns.byName(E[0]),N=e.columns.byName(E[1]);if($.init((e=>S[0][e])),N.init((e=>S[1][e])),g)try{const L=g.inputs[0].name,I=g.inputs[1].name;await g.prepare({[L]:$,[I]:N,...y}).call(!0)}catch(R){s.shell.error("Post-processing failed"),console.error(R)}if(A)return o.setUpdateIndicator(A.root,!1),A.helpUrl="/help/compute/sequence-space",A}}catch(O){s.shell.error("Dimensionality reduction failed"),console.error(O),v.close(),A&&o.setUpdateIndicator(A.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[c.vb])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await v();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await v();t(e)}}catch(e){n(e)}}))}(e,[t],r,[i],[1],[u],"MANHATTAN",l,h??!1,{...d,preprocessingFuncArgs:[d.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:d?.[c.vb],tableView:m})}async function Mt(e,t,n){const r=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const r=(await Tt()).getMonomerLib();await(0,At.V)(e,t,n,r)}finally{r.close()}}function $t(e){return new le.m(e).importFasta()}function Nt(e){const t=ce.GO.forColumn(e).stats;return Object.keys(t.freq)}async function Lt(e,t,n){return Et(e,t,n,oe.IDENTITY)}async function It(e,t,n){return Et(e,t,n,oe.SIMILARITY)}},8115:(e,t,n)=>{"use strict";n.d(t,{if:()=>l,nI:()=>c});var r=n(4328),i=(n(7389),n(6082)),s=n(1407),o=(n(4870),n(8070)),a=n(2003);function c(e,t,n){const r=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),r=e.charAt(0)===t,i=e.charAt(e.length-1)===t,s=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return r?i?`${n}${s}${n}`:`${n}${s}${n}|${n}${s}$`:i?`^${s}${n}|${n}${s}${n}`:`^${s}${n}|${n}${s}${n}|${n}${s}$`}(e,n):e,s=i.BitSet.create(t.length);for(let n=0;n<t.length;n++){const i=t.get(n);(i.match(r)||i===e)&&s.set(n,!0,!1)}return s}async function l(e,t){t.version!==t.temp["last-invalidated-version"]&&await async function(e){const t=i.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,o.cb)(10);const t=new Map,n=await(0,s.R)(e,!0,t);e.temp["monomeric-mols"]=n,e.temp["monomers-dict"]=t,e.temp["last-invalidated-version"]=e.version}finally{t.close()}}(t);const n=i.Column.string("helm",1).init((t=>e));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=a.Hi.HELM;const c=await(0,s.R)(n,!0,t.temp["monomers-dict"]);return(await r.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:c.get(0),molBlockFailover:""})).get(0)}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>o,l:()=>a});var r=n(4328),i=n(6082),s=n(826);function o(e,t,n=[],i=[],s=!0){const[o,c]=a(e,t,n,i);return s&&!o&&r.shell.warning(c),o}function a(e,t,n=[],o=[]){let a=!0,c="";const l=s.GO.forColumn(e);if(e.semType!==i.SEMTYPE.MACROMOLECULE)r.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=l.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))c=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!l.isHelm()){const e=l.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(c=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,c]}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>d,J:()=>l,b9:()=>u,gN:()=>a,uF:()=>s});var r,i,s,o=n(5437);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(r||(r={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(i||(i={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(s||(s={}));const a="MSA";var c,l;!function(e){e.CELL_CHANGING="isCellChanging"}(c||(c={})),function(e){e.SEPARATOR="."}(l||(l={}));const u="3.3.1",d={pepsea:{gapOpen:1.53,gapExtend:0,method:o.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{r:()=>s}),n(6082),n(7389);var r=n(4328),i=(n(1757),n(2003),n(826));async function s(e,t,n){const s=i.GO.forColumn(e).convert(t,n);e.dataFrame.columns.add(s);const o=await r.functions.call("Bio:detectMacromolecule",{col:s});return o&&(s.semType=o),await r.data.detectSemanticTypes(e.dataFrame),s}},6740:(e,t,n)=>{"use strict";n.d(t,{m8:()=>o});var r=n(4328),i=n(8070),s=n(5437);async function o(e=6e4){const t=await s.Nk.getDockerContainer();await async function(e,t=6e4){let n=e,s=!1;for(let o=0;o<t/200;++o){if(null===n&&(n=await r.dapi.docker.dockerContainers.find(e.id)),a(n)){s=!0;break}switch(n.status){case"stopped":await r.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,i.cb)(200)}if(!s)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>r});const r="H"},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>M});var r=n(4328),i=n(6082),s=n(7389),o=n(8070),a=n(2003),c=n(826),l=n(608),u=n(5437),d=n(966),h=n(4139),p=n(6740),m=n(567),f=n(5072),g=n.n(f),y=n(7825),w=n.n(y),b=n(7659),v=n.n(b),A=n(5056),E=n.n(A),C=n(540),T=n.n(C),S=n(1113),_=n.n(S),P=n(6369),x={};async function M(e={}){return new Promise((async(t,n)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=h.HX.pepsea.method,e.pepsea.gapOpen??=h.HX.pepsea.gapOpen,e.pepsea.gapExtend??=h.HX.pepsea.gapExtend;const a=e.col?.dataFrame??r.shell.t,c=e.col??a.columns.bySemType(i.SEMTYPE.MACROMOLECULE);if(null==c){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return r.shell.warning(e),void n(new l.Ap(s.divText(e)))}const d=s.input.choice("Method",{value:e.pepsea.method,items:u.ZY});d.setTooltip("Alignment method");const p=s.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const m=s.p(`Kalign version: ${h.b9}`,"kalign-version"),f=s.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const g=s.input.float("Gap extend",{value:e.pepsea.gapExtend});g.setTooltip("Gap extension penalty to skip the alignment");const y=s.inputs([f,g,p]),w=s.button("Alignment parameters",(()=>{y.hidden=!y.hidden,[f,g,p].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");w.classList.add("msa-params-button"),y.hidden=!0,w.prepend(s.icons.settings((()=>null)));const b=[d.root.style],v=[p.root.style,m.style];let A,E=c;const C=s.input.column("Sequence",{table:a,value:c,onValueChanged:async e=>{if(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,o.cb)(0),void(C.value=E);E=e,_.disabled=!1,A=await N(C.value,a,b,v,d,T,f,g,p)},filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE});C.setTooltip("Sequences column to use for alignment");const T=s.input.column("Clusters",{table:a,value:e.clustersCol});T.nullable=!0;const S=s.dialog("MSA").add(C).add(T).add(d).add(y).add(w).add(m).onOK((async()=>{await $(C,a,A,t,n)})),_=S.getButton("OK");if(C.fireChanged(),e.col)return A=await N(e.col,a,b,v,d,T,f,g,p),void await $(C,a,A,t,n);S.show()}))}async function $(e,t,n,s,o){let a=null;const c=i.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return o("PepSeA container has not started");t.columns.add(a),await r.data.detectSemanticTypes(t),s(a)}catch(e){o(e)}finally{c.close()}}async function N(e,t,n,s,o,f,g,y,w){try{if(e.semType!==i.SEMTYPE.MACROMOLECULE)return;const r=t.columns.getUnusedName(`msa(${e.name})`);if((0,d.V)(e,e.name,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT],!1)){L(n,s,"kalign"),g.value=null,y.value=null,w.value=null;const t=c.GO.forColumn(e),i=t.isFasta()?e:t.convert(a.Hi.FASTA);return async()=>await(0,l.eE)(i,!1,r,f.value)}if((0,d.V)(e,e.name,[a.Hi.HELM],[],!1))return L(n,s,"pepsea"),g.value??=h.HX.pepsea.gapOpen,y.value??=h.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(e,r,o.value,g.value,y.value,f.value));if((0,d.V)(e,e.name,[a.Hi.SEPARATOR],[a.YI.UN],!1)){const t=c.GO.forColumn(e).convert(a.Hi.HELM);return L(n,s,"pepsea"),g.value??=h.HX.pepsea.gapOpen,y.value??=h.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(t,r,o.value,g.value,y.value,f.value))}return g.value=null,y.value=null,w.value=null,void L(n,s,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();r.shell.error(t),m._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}x.styleTagTransform=_(),x.setAttributes=E(),x.insert=v().bind(null,"head"),x.domAPI=w(),x.insertStyleElement=T(),g()(P.A,x),P.A&&P.A.locals&&P.A.locals},608:(e,t,n)=>{"use strict";n.d(t,{Ap:()=>G,aZ:()=>U,eE:()=>D});var r=n(7389),i=n(6082),s=n(1991),o=n.n(s),a=n(3516),c=n(2003);const l=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),d=Symbol("Comlink.releaseProxy"),h=Symbol("Comlink.thrown"),p=e=>"object"==typeof e&&null!==e||"function"==typeof e,m=new Map([["proxy",{canHandle:e=>p(e)&&e[l],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>p(e)&&h in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(r){if(!r||!r.data)return;const{id:i,type:s,path:o}=Object.assign({path:[]},r.data),a=(r.data.argumentList||[]).map(T);let c;try{const t=o.slice(0,-1).reduce(((e,t)=>e[t]),e),n=o.reduce(((e,t)=>e[t]),e);switch(s){case"GET":c=n;break;case"SET":t[o.slice(-1)[0]]=T(r.data.value),c=!0;break;case"APPLY":c=n.apply(t,a);break;case"CONSTRUCT":c=function(e){return Object.assign(e,{[l]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),c=function(e,t){return E.set(e,t),e}(t,[t])}break;case"RELEASE":c=void 0;break;default:return}}catch(e){c={value:e,[h]:0}}Promise.resolve(c).catch((e=>({value:e,[h]:0}))).then((e=>{const[r,o]=C(e);t.postMessage(Object.assign(Object.assign({},r),{id:i}),o),"RELEASE"===s&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return b(e,[],t)}function w(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,t=[],n=function(){}){let r=!1;const i=new Proxy(n,{get(n,s){if(w(r),s===d)return()=>S(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),r=!0}));if("then"===s){if(0===t.length)return{then:()=>i};const n=S(e,{type:"GET",path:t.map((e=>e.toString()))}).then(T);return n.then.bind(n)}return b(e,[...t,s])},set(n,i,s){w(r);const[o,a]=C(s);return S(e,{type:"SET",path:[...t,i].map((e=>e.toString())),value:o},a).then(T)},apply(n,i,s){w(r);const o=t[t.length-1];if(o===u)return S(e,{type:"ENDPOINT"}).then(T);if("bind"===o)return b(e,t.slice(0,-1));const[a,c]=A(s);return S(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},c).then(T)},construct(n,i){w(r);const[s,o]=A(i);return S(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:s},o).then(T)}});return i}function v(e){return Array.prototype.concat.apply([],e)}function A(e){const t=e.map(C);return[t.map((e=>e[0])),v(t.map((e=>e[1])))]}const E=new WeakMap;function C(e){for(const[t,n]of m)if(n.canHandle(e)){const[r,i]=n.serialize(e);return[{type:"HANDLER",name:t,value:r},i]}return[{type:"RAW",value:e},E.get(e)||[]]}function T(e){switch(e.type){case"HANDLER":return m.get(e.name).deserialize(e.value);case"RAW":return e.value}}function S(e,t,n){return new Promise((r=>{const i=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==i||(e.removeEventListener("message",t),r(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:i},t),n)}))}const _="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{e.stdout+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{stdout:i}})},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";e[s]+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{[s]:i}})}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",P=typeof window<"u"&&window.Blob&&new Blob([atob(_)],{type:"text/javascript;charset=utf-8"});function x(){const e=P&&(window.URL||window.webkitURL).createObjectURL(P);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+_)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const M={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class ${constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},M,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new x;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class L{static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}L.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class I{constructor(e="categorial"){this.aa2num=L.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const r=["NH2","COOH"];if(e.startsWith(r[0])){const n=r[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${r[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(r[1])){const t=r[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${r[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return I._dropDefises(I._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let r=0;r<t;++r){const t=e[r];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[r]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const r=e[n];(0,N.vA)(r in this.num2aa,`Unknown code '${r}' found in vector '${e}'`),t+=this.num2aa[r]}return t}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function H(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function D(e,t=!1,n="",r=null,s,o,l){let u=e.toList();t&&(u=u.map((e=>I.clean(e).replace(/\-/g,""))));const d=e.length;r??=i.Column.string("Clusters",d).init("0"),r.type!=i.COLUMN_TYPE.STRING&&(r=r.convertTo(i.TYPE.STRING)),r.compact();const h=r.categories,p=r.getRawData(),m=new Array(h.length),f=new Array(h.length);for(let e=0;e<d;++e){const t=p[e];(m[t]??=[]).push(u[e]),(f[t]??=[]).push(e)}U(f,h);const g=await new $(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=i.Column.string(n,d);for(let e=0;e<h.length;++e){const t=H(m[e]);await g.fs.writeFile(O,t);const n=`${void 0!==s?` --gpo ${s}`:""}${void 0!==o?` --gpe ${o}`:""}${void 0!==l?` --tgpe ${l}`:""}`,r=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(r);const i=await g.cat(k);if(!i){const e=F(r,1);throw new Error(e)}const c=new a.m(i).sequencesArray,u=f[e];for(let e=0;e<c.length;++e)y.set(u[e],c[e])}const w=e.meta.units,b=e.getTag(c.gp.alphabet);return y.meta.units=w,y.setTag(c.gp.aligned,"SEQ.MSA"),y.setTag(c.gp.alphabet,b),y.semType=i.SEMTYPE.MACROMOLECULE,y}function F(e,t){const n=[],r=/^.+ERROR : (.+)$/gm;let i;for(;null!=(i=r.exec(e))&&(void 0===t||n.length<t);)n.push(i[1]);return n.join("\n")}function U(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=r.div([r.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...o()(n).take(3).map((e=>{let i=t[e];return i.length>25&&(i=i.slice(0,25)+"..."),r.divText(`"${i}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[r.divText("...")]:[]]);throw new G(e)}}},5437:(e,t,n)=>{"use strict";n.d(t,{Nk:()=>d,ZY:()=>h,GD:()=>m});var r=n(4328),i=n(6082),s=n(2003),o=function(e,t,n,r){return new(n||(n=Promise))((function(i,s){function o(e){try{c(r.next(e))}catch(e){s(e)}}function a(e){try{c(r.throw(e))}catch(e){s(e)}}function c(e){var t;e.done?i(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}c((r=r.apply(e,t||[])).next())}))};function a(e){return o(this,void 0,void 0,(function*(){try{return yield e()}catch(e){throw console.error("Promise rejected"),new Error("Promise rejected")}}))}var c=n(608),l=n(4139),u=n(567);const d=new class{dcName="bio";async getDockerContainer(){return await r.dapi.docker.dockerContainers.filter(this.dcName).first()}},h=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],p=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function m(e,t,n="ginsi",r=1.53,o=0,u=null,h){const m=await d.getDockerContainer();if("started"!==m.status&&"checking"!==m.status)throw new Error("PepSeA container has not started yet");const g=e.length;u??=i.Column.int("Clusters",g).init(0),u.type!=i.COLUMN_TYPE.STRING&&(u=u.convertTo(i.TYPE.STRING));const y=u.categories,w=u.getRawData(),b=new Array(y.length),v=new Array(y.length);for(let t=0;t<g;++t){const n=w[t],r=y[n];if(""===r)continue;const i=y.indexOf(r),s=e.get(t);s&&((b[i]??=[]).push({ID:t.toString(),HELM:s}),(v[n]??=[]).push(t))}(0,c.aZ)(v,y);const A=new Array(g);for(const e of b){const t=(await a((()=>f(m.id,e,n,r,o,h)))).Alignment;for(const e of t)A[parseInt(e.ID)]=Object.entries(e).filter((e=>!p.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(l.J.SEPARATOR)}const E=i.Column.fromStrings(t,A);return E.meta.units=s.Hi.SEPARATOR,E.setTag(s.gp.separator,l.J.SEPARATOR),E.setTag(s.gp.aligned,"SEQ.MSA"),E.setTag(s.gp.alphabet,s.YI.UN),E.setTag(s.gp.alphabetIsMultichar,"true"),E.semType=i.SEMTYPE.MACROMOLECULE,E}async function f(e,t,n,i,s,o){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${i}&gap_extend=${s}`;let l;if("fetchProxy"in r.dapi.docker.dockerContainers){const t=window.performance.now(),n=await r.dapi.docker.dockerContainers.fetchProxy(e,c,a),i=window.performance.now();u._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${i-t} ms`);const s="application/json"===n.headers.get("content-type");if(!n.ok&&s){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const r=e["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`);throw new Error(n.statusText)}if(!n.ok&&!s){const e=await n.text();throw new Error(`Error: ${e}`)}if(!s){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}l=await n.json()}else{const t=await r.dapi.docker.dockerContainers.request(e,c,a);if(!t)throw new Error("Empty response");l=JSON.parse(t);const n=l["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const i=l["datagrok-error"];if(i)throw new Error(`Datagrok error: ${i}`)}if("pepsea-stderr"in l){const e=l["pepsea-stderr"];o?.warning(e)}return l}},3890:(e,t,n)=>{"use strict";n.d(t,{aS:()=>c,wz:()=>a}),n(6082),n(7389),n(4328);var r=n(1991),i=n.n(r),s=n(826);const o=60;function a(e,t,n=o,r="\n"){const i=s.GO.forColumn(t),a=[];for(let s=0;s<t.length;s++){const t=e.map((e=>e.get(s).toString())).join("|"),o=c(i.getSplitted(s),n);a.push(`>${t}${r}`);for(const e of o)a.push(`${e}${r}`)}return"".concat(...a)}function c(e,t=o){let n=0;const r=e.length,s=[];for(;n<r;){const r=i()(e.originals).slice(n,n+t).toArray(),o=r.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");s.push(o),n+=r.length}return s}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var r=n(4328),i=n(7384),s=n(826),o=n(2003),a=n(6717),c=n(8312),l=n(966);async function u(e,t,n,u){let d;try{d=await(0,a.j)()}catch(e){return r.shell.warning('Transformation to atomic level requires package "Chem" installed.'),null}let h=null;if(n){const n=await(0,c.Q)(),r=s.GO.forColumn(t);let i,a,l;r.isHelm()?a=t:(l=t.name,t.name=`__${l}`,a=r.convert(o.Hi.HELM),a.name=l,e.columns.add(a,!1));try{i=await n.helmToAtomicLevel(a,!0,!0)}finally{a!==t&&(e.columns.remove(a.name),t.name=l)}e.columns.add(i.molCol),e.columns.add(i.molHighlightCol),h=i.molCol}else{if(!(0,l.V)(t,"To Atomic Level"))return null;const n=await(0,i.C4)(e,t,u);null!==n.col&&(e.columns.add(n.col,!0),h=n.col)}return h&&await r.data.detectSemanticTypes(e),h}},5785:(e,t,n)=>{"use strict";n.d(t,{k:()=>u});var r=n(4328),i=n(6082),s=n(8070),o=n(966),a=n(3077),c=n(4139),l=n(439);async function u(e,t){if(await(0,s.cb)(10),!(0,o.V)(t,"Sequence space"))return e;const n=(0,a.R)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=c.uF.MONOMER,e.setTag(l.gp.alphabet,t.getTag(l.gp.alphabet));const d=/(\d+)(?: \((\d+)\))?/,h=e=>{d.lastIndex=0;const t=e.match(d);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const r=n.columns.byIndex(e);r.semType=c.uF.MONOMER,r.setTag(l.gp.alphabet,t.getTag(l.gp.alphabet));const i=100;let s=0;for(;u.columns.byName(r.name)&&s<i;)r.name=h(r.name),s++;u.columns.add(r)}await r.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(i.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4870:(e,t,n)=>{"use strict";function r(e,t){e.innerHTML="",e.append(t)}n.d(t,{K:()=>r}),n(4328),n(6082)},8047:(e,t,n)=>{"use strict";n.d(t,{VN:()=>p,n5:()=>c,Ue:()=>h,Tc:()=>d,eN:()=>m}),n(4328),n(7389);var r=n(6082),i=(n(1757),n(1991),n(1858),n(826),n(2003)),s=n(4326),o=n(2738);n(8070),n(7602);var a,c,l,u=n(2174);n(567),HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new r.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},r.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class d{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class h{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,r){this.pos=e,this.name=t,this._freqs=n??{},r?.sumRowCount&&(this.sumRowCount=r.sumRowCount),r?.sumValueForHeight&&(this.sumPlotValue=r.sumValueForHeight),r?.label&&(this._label=r.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new d),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?r.Column.fromFloat32Array(n,e):e instanceof Int32Array?r.Column.fromInt32Array(n,e):r.Column.fromList(r.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===s.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const r=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-r*Math.log2(r)}}else if(e===s.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,a,c,l,u,d){const h=i===s.fH.Entropy?n*(a-this.sumPlotValueForHeight)/a:n;let p=d*u+(n-h-1);const m=Object.entries(this._freqs).sort(((e,t)=>e[0]!==o._S&&t[0]!==o._S?t[1].value-e[1].value:e[0]===o._S&&t[0]===o._S?0:e[0]===o._S?-1:1));for(const[n,i]of m){const n=h*i.plotValue/this.sumPlotValue;i.bounds=new r.Rect((e-t)*u*c,p,l*u,n),p+=n}}render(e,t,n,r,s){for(const[a,c]of Object.entries(this._freqs))if(a!==o._S){const o=(0,i.zS)(a,5),l=c.bounds,u=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(u,l.top,l.width,l.height),e.fillStyle=s.get(a)??s.get("other"),e.textAlign="left",e.font=t;const d=e.measureText(o);e.setTransform(l.width/d.width,0,0,l.height/r,u,l.top),e.fillText(o,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,r])=>r.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,u.F)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(a||(a={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(c||(c={})),s.Fo,function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(l||(l={}));const p=new class{render=20};function m(e,t,n,r,i){let s=0,o=-1;for(;-1!=(o=n.findNext(o,!0));){const e=t.getSplitted(o),n=i.pos,a=n<e.length?e.getCanonical(n):null;null!==a&&a===r&&s++}return s}r.JsViewer},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>o,n:()=>s});var r=n(1858),i=n(567);class s{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(i._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{onChanged=new r.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>S,AR:()=>T});var r=n(7389),i=n(6082),s=n(4328),o=n(1991),a=n.n(o),c=n(1858),l=n(2003),u=n(8070),d=n(826),h=n(7602),p=n(8115),m=n(4577),f=n(1757),g=n.n(f),y=n(9124),w=n(9192),b=n(4870),v=n(567);class A extends m.O{emptyProps=new m.n("");helmEditor;_filterPanel=r.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++A.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.logger=v._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,y.b)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await r.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,c.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=r.div(),n=e.createWebEditorApp(t,this.props.substructure),r.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(r.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,w.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,w.AP)(e),i=this._filterPanel;i.innerText="error",i.classList.add("d4-error"),r.tooltip.bind(i,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=r.divText("Click to edit","helm-substructure-filter");(0,b.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}const E="bio-substructure-filter";class C{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,r,i){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=r,this.bitset=i}}class T extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class S extends i.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=r.divV([]),this.loader=r.loader(),this.calculating=!1,this.filterSyncer=new h.g(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++S.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(i.SEMTYPE.MACROMOLECULE)),d.GO.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===l.Hi.FASTA?new _:this.notation===l.Hi.SEPARATOR?new P(this.column.getTag(l.gp.separator)):new A,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(i.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(s.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(s.events.onCustomEvent(E).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=i.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),s.events.fireCustomEvent(E,new C(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new c.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const r=this.filterSyncer.resetErrors();if(r.length>0)throw r[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class P extends m.O{emptyProps=new T("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=r.input.string("",{value:"",onValueChanged:e=>{this.props=new T(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=r.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new T(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new T("")}get filterPanel(){return r.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,p.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>v});var r=n(7389),i=n(6082),s=(n(1991),n(2003),n(4152),n(5072)),o=n.n(s),a=n(7825),c=n.n(a),l=n(7659),u=n.n(l),d=n(5056),h=n.n(d),p=n(540),m=n.n(p),f=n(1113),g=n.n(f),y=n(5999),w={};w.styleTagTransform=g(),w.setAttributes=h(),w.insert=u().bind(null,"head"),w.domAPI=c(),w.insertStyleElement=m(),o()(y.A,w),y.A&&y.A.locals&&y.A.locals,n(826);var b=n(2738);function v(e,t){let n=0,s=null;for(const e of Object.values(t))n+=e,s=null===s?e:Math.max(s,e);const o=s/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,s])=>{const a=s/n,c=e.get(t),l=r.div("",{classes:"macromolecule-cell-comp-analysis-bar"});l.style.width=50*a/o+"px",l.style.backgroundColor=c,b._S===t&&(l.style.borderWidth="1px",l.style.borderStyle="solid",l.style.borderColor=i.Color.toHtml(i.Color.lightGray));const u=b._S===t?"-":t,d=r.div(`${(100*a).toFixed(2)}%`),h=r.div([l,d],{classes:"macromolecule-cell-comp-analysis-value"});return{[u]:h}}))),c=r.tableFromMap(a);return Array.from(c.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),c}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:r,normalizeIPv4:i,removeDotSegments:s,recomposeAuthority:o,normalizeComponentEncoding:a}=n(4834),c=n(343);function l(e,t,n,r){const i={};return r||(e=p(u(e,n),n),t=p(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(i.scheme=t.scheme,i.userinfo=t.userinfo,i.host=t.host,i.port=t.port,i.path=s(t.path||""),i.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(i.userinfo=t.userinfo,i.host=t.host,i.port=t.port,i.path=s(t.path||""),i.query=t.query):(t.path?("/"===t.path.charAt(0)?i.path=s(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?i.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:i.path=t.path:i.path="/"+t.path,i.path=s(i.path)),i.query=t.query):(i.path=e.path,void 0!==t.query?i.query=t.query:i.query=e.query),i.userinfo=e.userinfo,i.host=e.host,i.port=e.port),i.scheme=e.scheme),i.fragment=t.fragment,i}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},r=Object.assign({},t),i=[],a=c[(r.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,r),void 0!==n.path&&(r.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==r.reference&&n.scheme&&(i.push(n.scheme),i.push(":"));const l=o(n,r);if(void 0!==l&&("suffix"!==r.reference&&i.push("//"),i.push(l),n.path&&"/"!==n.path.charAt(0)&&i.push("/")),void 0!==n.path){let e=n.path;r.absolutePath||a&&a.absolutePath||(e=s(e)),void 0===l&&(e=e.replace(/^\/\//u,"/%2F")),i.push(e)}return void 0!==n.query&&(i.push("?"),i.push(n.query)),void 0!==n.fragment&&(i.push("#"),i.push(n.fragment)),i.join("")}const d=Array.from({length:127},((e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t)))),h=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(e,t){const n=Object.assign({},t),s={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},o=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const l=e.match(h);if(l){if(s.scheme=l[1],s.userinfo=l[3],s.host=l[4],s.port=parseInt(l[5],10),s.path=l[6]||"",s.query=l[7],s.fragment=l[8],isNaN(s.port)&&(s.port=l[5]),s.host){const e=i(s.host);if(!1===e.isIPV4){const t=r(e.host,{isIPV4:!1});s.host=t.host.toLowerCase(),a=t.isIPV6}else s.host=e.host,a=!0}void 0!==s.scheme||void 0!==s.userinfo||void 0!==s.host||void 0!==s.port||s.path||void 0!==s.query?void 0===s.scheme?s.reference="relative":void 0===s.fragment?s.reference="absolute":s.reference="uri":s.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==s.reference&&(s.error=s.error||"URI is not a "+n.reference+" reference.");const e=c[(n.scheme||s.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&s.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,r=e.length;n<r;++n)if(t=e.charCodeAt(n),t>126||d[t])return!0;return!1}(s.host))try{s.host=URL.domainToASCII(s.host.toLowerCase())}catch(e){s.error=s.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(o&&void 0!==s.scheme&&(s.scheme=unescape(s.scheme)),o&&void 0!==s.userinfo&&(s.userinfo=unescape(s.userinfo)),o&&void 0!==s.host&&(s.host=unescape(s.host)),void 0!==s.path&&s.path.length&&(s.path=escape(unescape(s.path))),void 0!==s.fragment&&s.fragment.length&&(s.fragment=encodeURI(decodeURIComponent(s.fragment)))),e&&e.parse&&e.parse(s,n)}else s.error=s.error||"URI can not be parsed.";return s}const m={SCHEMES:c,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const r=Object.assign({scheme:"null"},n);return u(l(p(e,r),p(t,r),r,!0),{...r,skipEscape:!0})},resolveComponents:l,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function r(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function i(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function s(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const o={scheme:"http",domainHost:!0,parse:i,serialize:s},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=r(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(r(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},c={http:o,https:{scheme:"https",domainHost:o.domainHost,parse:i,serialize:s},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const r=e.path.match(n);if(r){const n=t.scheme||e.scheme||"urn";e.nid=r[1].toLowerCase(),e.nss=r[2];const i=`${n}:${t.nid||e.nid}`,s=c[i];e.path=void 0,s&&(e=s.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",r=e.nid.toLowerCase(),i=`${n}:${t.nid||r}`,s=c[i];s&&(e=s.serialize(e,t));const o=e,a=e.nss;return o.path=`${r||t.nid}:${a}`,t.skipEscape=!0,o},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const r=e;return r.uuid=r.nss,r.nss=void 0,n.tolerant||r.uuid&&t.test(r.uuid)||(r.error=r.error||"UUID is not valid."),r},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=c},4914:e=>{"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(e,t,n)=>{"use strict";const{HEX:r}=n(4914);function i(e){if(c(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(/^(?:(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])\.){3}(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])$/u)||[],[n]=t;return n?{host:a(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function s(e,t=!1){let n="",i=!0;for(const t of e){if(void 0===r[t])return;"0"!==t&&!0===i&&(i=!1),i||(n+=t)}return t&&0===n.length&&(n="0"),n}function o(e,t={}){if(c(e,":")<2)return{host:e,isIPV6:!1};const n=function(e){let t=0;const n={error:!1,address:"",zone:""},r=[],i=[];let o=!1,a=!1,c=!1;function l(){if(i.length){if(!1===o){const e=s(i);if(void 0===e)return n.error=!0,!1;r.push(e)}i.length=0}return!0}for(let s=0;s<e.length;s++){const u=e[s];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!l())break;o=!0}else i.push(u);else{if(!0===a&&(c=!0),!l())break;if(t++,r.push(":"),t>7){n.error=!0;break}s-1>=0&&":"===e[s-1]&&(a=!0)}}return i.length&&(o?n.zone=i.join(""):c?r.push(i.join("")):r.push(s(i))),n.address=r.join(""),n}(e);if(n.error)return{host:e,isIPV6:!1};{let e=n.address,t=n.address;return n.zone&&(e+="%"+n.zone,t+="%25"+n.zone),{host:e,escapedHost:t,isIPV6:!0}}}function a(e,t){let n="",r=!0;const i=e.length;for(let s=0;s<i;s++){const o=e[s];"0"===o&&r?(s+1<=i&&e[s+1]===t||s+1===i)&&(n+=o,r=!1):(r=o===t,n+=o)}return n}function c(e,t){let n=0;for(let r=0;r<e.length;r++)e[r]===t&&n++;return n}const l=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,d=/^\/\.\.(?:\/|$)/u,h=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e,t){const n=[];if(void 0!==e.userinfo&&(n.push(e.userinfo),n.push("@")),void 0!==e.host){let t=unescape(e.host);const r=i(t);if(r.isIPV4)t=r.host;else{const n=o(r.host,{isIPV4:!1});t=!0===n.isIPV6?`[${n.escapedHost}]`:e.host}n.push(t)}return"number"!=typeof e.port&&"string"!=typeof e.port||(n.push(":"),n.push(String(e.port))),n.length?n.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(l))e=e.replace(l,"");else if(e.match(u))e=e.replace(u,"/");else if(e.match(d))e=e.replace(d,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(h);if(!n)throw new Error("Unexpected dot segment condition");{const r=n[0];e=e.slice(r.length),t.push(r)}}return t.join("")},normalizeIPv4:i,normalizeIPv6:o,stringArrayToHexStripped:s}},3837:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(r){var i=t[r];if(void 0!==i)return i.exports;var s=t[r]={id:r,loaded:!1,exports:{}};return e[r].call(s.exports,s,s.exports,n),s.loaded=!0,s.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var r in t)n.o(t,r)&&!n.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var r=t.getElementsByTagName("script");if(r.length)for(var i=r.length-1;i>-1&&(!e||!/^http(s?):/.test(e));)e=r[i--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var r={};(()=>{"use strict";n.r(r),n.d(r,{_package:()=>_e,test:()=>Pe,tests:()=>t.CN});var e=n(6082),t=n(8070);(0,t.L1)("_first",(()=>{(0,t.t6)("_first",(async()=>{}))}));var i=n(8924),s=n(7362),o=n(1093);(0,t.L1)("Palettes",(()=>{(0,t.t6)("testPaletteN",(async()=>{await async function(){const e=o.A.Chromatogram;(0,t.E3)(e instanceof s.e,!0),(0,t.E3)(e instanceof o.A,!0)}()})),(0,t.t6)("testPaletteAA",(async()=>{await async function(){const e=i.X.Lesk,n=i.X.RasMol,r=i.X.GrokGroups;(0,t.E3)(e instanceof s.e,!0),(0,t.E3)(n instanceof s.e,!0),(0,t.E3)(r instanceof s.e,!0),(0,t.E3)(e instanceof i.X,!0),(0,t.E3)(n instanceof i.X,!0),(0,t.E3)(r instanceof i.X,!0)}()})),(0,t.t6)("testPalettePtMe",(async()=>{const e=i.X.GrokGroups.get("MeNle"),n=i.X.GrokGroups.get("MeA"),r=i.X.GrokGroups.get("MeG"),s=i.X.GrokGroups.get("MeF"),o=i.X.GrokGroups.get("L"),a=i.X.GrokGroups.get("A"),c=i.X.GrokGroups.get("G"),l=i.X.GrokGroups.get("F");(0,t.E3)(e,o),(0,t.E3)(n,a),(0,t.E3)(r,c),(0,t.E3)(s,l)}))}));var a=n(4328),c=n(567),l=n(2003),u=n(826);class d{units;aligned;alphabet;alphabetSize;alphabetIsMultichar;separator;constructor(e,t,n,r,i,s){this.units=e,this.aligned=t,this.alphabet=n,this.alphabetSize=r,this.alphabetIsMultichar=i,this.separator=s}}async function h(t){const n=e.Column.fromList(e.TYPE.STRING,"col1",t);if(await a.functions.call("Bio:detectMacromolecule",{col:n}),n.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${n.semType}', units='${n.meta.units}'.`;throw new Error(e)}}async function p(t,n){const r=(await t()).getCol(n),i=await a.functions.call("Bio:detectMacromolecule",{col:r});if(i&&(r.semType=i),r.semType===e.SEMTYPE.MACROMOLECULE){const e=`Negative test detected semType='${r.semType}', units='${r.meta.units}'.`;throw new Error(e)}}async function m(n,r,i,s,o,c,d=null){const h=e.Column.fromList(e.TYPE.STRING,"seq",n),p=await a.functions.call("Bio:detectMacromolecule",{col:h});p&&(h.semType=p),(0,t.E3)(h.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(h.meta.units,r),(0,t.E3)(h.getTag(l.gp.aligned),i),(0,t.E3)(h.getTag(l.gp.alphabet),s),d&&(0,t.E3)(h.getTag(l.gp.separator),d);const m=u.GO.forColumn(h);(0,t.E3)(m.getAlphabetSize(),o),(0,t.E3)(m.getAlphabetIsMultichar(),c),m.isHelm()||((0,t.E3)(m.aligned,i),(0,t.E3)(m.alphabet,s))}async function f(n,r,i,s,o,c,d,h=null){const p=(await n()).col(r),m=await a.functions.call("Bio:detectMacromolecule",{col:p});m&&(p.semType=m),(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,i),(0,t.E3)(p.getTag(l.gp.aligned),s),(0,t.E3)(p.getTag(l.gp.alphabet),o),h&&(0,t.E3)(p.getTag(l.gp.separator),h);const f=u.GO.forColumn(p);(0,t.E3)(f.getAlphabetSize(),c),(0,t.E3)(f.getAlphabetIsMultichar(),d),f.isHelm()||((0,t.E3)(f.aligned,s),(0,t.E3)(f.alphabet,o))}async function g(e,t){const n=await e(),r=[];for(const i of n.columns.names())if(i in t){const n=t[i];try{await f(e,i,n.units,n.aligned,n.alphabet,n.alphabetSize,n.alphabetIsMultichar,n.separator)}catch(e){const t=e.toString();r.push(`Positive col '${i}' failed: ${t}`)}}else try{await p(e,i)}catch(e){const t=e.toString();r.push(`Negative col '${i}' failed: ${t}`)}if(r.length>0)throw new Error(r.join("\n"))}(0,t.L1)("detectors",(()=>{const n={negEmpty:{csv:"id,col1\n1,\n2,\n3,\n4,\n5,",neg:["col1"]},negNum1:{csv:"col1\n1\n2\n3",neg:["col1"]},negNum2:{csv:"col1\n4\n5\n6\n7",neg:["col1"]},negNum3:{csv:"col1\n8\n9\n10\n11\n12",neg:["col1"]},negSmiles:{csv:"col1\nCCCCN1C(=O)CN=C(c2cc(F)ccc12)C3CCCCC3\nC1CCCCC1\nCCCCCC",neg:["col1"]},negSmilesWithSquareBrackets:{csv:"col1\nCl.c1ccc2nc3ccccc3cc2c1\nOc1cccc2cc3ccccc3cc12\n[SeH]c1ccc2ccccc2c1",neg:["col1"]},negFastaUnSingleChar:{csv:"col1\nAlanine\nCysteine\nAspartic acid\nGlutamic acid\nPhenylalanine",neg:["col1"]},fastaMsaSameLength:{csv:"seq\nFWPHEYFWPHEYYV\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1,void 0)}},fastaExtSameLength:{csv:"seq\nFW[Ac]PHEYFWPH\nYN[Re]VYNRQWYV\n[Me]EYVMPS[Et]",pos:{seq:new d(l.Hi.FASTA,"SEQ",l.YI.UN,16,!0,void 0)}},fastaMsaExtSameLength:{csv:"seq\nFW[Ac]PHEY[Re]WPH\nYN[Re]VYNR[Ac]WYV\n[Me]EYVMPSFW[Me]H",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.UN,14,!0,void 0)}},fastaMsaExtManyMinus:{csv:"seq\n[D-Tic]-------[D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]N[D-Orn][D-aThr]-[Phe_4Me]\n[Phe_2F]--------[Tyr_ab-dehydroMe][dV][Aca]N[D-Orn][D-aThr]-[Phe_4Me]\n[D-Tic]-[Hcy]QTWQ[Phe_4NH2][D-Tyr_Et][Tyr_ab-dehydroMe][dV][Cys_SEt]----[Phe_4Me]",pos:{seq:new d(l.Hi.FASTA,"SEQ.MSA",l.YI.UN,17,!0,void 0)}},sepSameLength:{csv:"seq\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2",pos:{seq:new d(l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,5,!0,"-")}},sepMsaSameLength:{csv:"seq\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A(2)-A-A-A-C(2)-A-A-A-A-C(1)-G-NH2\nAc(1)-A-A-A-A-A-A-A-A-A-A-A-A-A-C(1)-G-NH2",pos:{seq:new d(l.Hi.SEPARATOR,"SEQ",l.YI.UN,5,!0,"-")}},helmSameLength:{csv:"seq\nPEPTIDE1{Ac(1).A.A.A.A.A.A.A.A.A.A.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ab(1).Y.V.K.H.P.F.W.R.W.Y.A.A.A.C(1).G.NH2}$$$$\nPEPTIDE1{Ad(1).S.W.Y.C.K.H.P.M.W.A.A.A.A.C(1)-G-NH2}$$$$",pos:{seq:new d(l.Hi.HELM,null,null,19,void 0,void 0)}}};for(const[r,i]of Object.entries(n))(0,t.t6)(`csvData2-${r}`,(async()=>{const t=(s=r,async()=>{const t=n[s].csv,r=e.DataFrame.fromCsv(t);return await a.data.detectSemanticTypes(r),r});var s;for(const e of i.neg??[])await p(t,e);for(const[e,n]of Object.entries(i.pos??{}))await f(t,e,n.units,n.aligned,n.alphabet,n.alphabetSize,n.alphabetIsMultichar,n.separator)}));const r=new class{csvFastaDna1="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC";fastaRna1="seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC";fastaPt1="seq\nFWPHEY\nYNRQWYV\nMKPSEYV";fastaUn="seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]DN\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Aca]";sepDna="seq\nA*C*G*T*C*A*C*G*T*C\nC*A*G*T*G*T*C*A*G*T*G*T\nT*T*C*A*A*C*T*T*C*A*A*C";sepRna="seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C";sepPt="seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V";sepUn1="seq\nabc-dfgg-abc1-cfr3-rty-wert-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-cfr3-wert-rut12";sepUn2="seq\nabc/dfgg/abc1/cfr3/rty/wert/abc/dfgg/abc1/cfr3/rty/wert\nrut12/her2/rty/wert//abc/abc1/dfgg/rut12/her2/rty/wert//abc/abc1/dfgg\nrut12/rty/her2/abc/cfr3//wert/rut12/rut12/rty/her2/abc/cfr3//wert/rut12";sepMsaDna1="seq\nA-C--G-T--C-T-A-C--G-T--C-T\nC-A-C--T--G-T-C-A-C--T--G-T\nA-C-C-G-T-A-C-T-A-C-C-G-T-A-C-T";sepMsaUnWEmpty="seq\nm1-M-m3-mon4-mon5-N-T-MON8-N9-m1-M-m3-mon4-mon5-N-T-MON8-N9\nm1-mon2-m3-mon4-mon5-Num--MON8-N9-m1-mon2-m3-mon4-mon5-Num--MON8-N9\n\nmon1-M-mon3-mon4-mon5---MON8-N9-mon1-M-mon3-mon4-mon5---MON8-N9";sepComplex="seq\nAc(1)-F-K(AEEA-AEEA-R-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2\nAc(1)-F-K(AEEA-ARRA-W-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2\nAc(1)-F-K(AEEA-AEEA-Ac)-L-mF-V-Y-mNle-D-W-N-mF-C(1)-G-NH2";fastaMsaDna1="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT";fastaMsaPt1="seq\nFWR-WYV-KHPFWR-WYV-KHP\nYNR-WYV-KHPYNR-WYV-KHP\nMWRSWY-CKHPMWRSWY-CKHP"},i={fastaPtCsv:"System:AppData/Bio/samples/FASTA_PT.csv",msaComplex:"System:AppData/Bio/samples/MSA.csv",fastaCsv:"System:AppData/Bio/samples/FASTA.csv",helmCsv:"System:AppData/Bio/samples/HELM.csv",peptidesComplex:"System:AppData/Bio/tests/peptides_complex_msa.csv",peptidesSimple:"System:AppData/Bio/tests/peptides_simple_msa.csv",testDemogCsv:"System:AppData/Bio/tests/testDemog.csv",testHelmCsv:"System:AppData/Bio/tests/testHelm.csv",testIdCsv:"System:AppData/Bio/tests/testId.csv",testSmilesCsv:"System:AppData/Bio/tests/testSmiles.csv",testSmiles2Csv:"System:AppData/Bio/tests/testSmiles2.csv",testSmilesShort:"System:AppData/Bio/tests/testSmilesShort.csv",testActivityCliffsCsv:"System:AppData/Bio/tests/testActivityCliffs.csv",testCerealCsv:"System:AppData/Bio/tests/testCereal.csv",testUnichemSources:"System:AppData/Bio/tests/testUnichemSources.csv",testDmvOffices:"System:AppData/Bio/tests/testDmvOffices.csv",testAlertCollection:"System:AppData/Bio/tests/testAlertCollection.csv",testSpgi100:"System:AppData/Bio/tests/testSpgi100.csv",testSpgi:"System:AppData/Bio/tests/SPGI-derived.csv",testUrl:"System:AppData/Bio/tests/testUrl.csv"},s={};function o(e,t=c){return async()=>(e in s||(s[e]=(async()=>await t(i[e]))().catch((t=>{throw delete s[e],t}))),s[e])}async function c(t){const n=await a.dapi.files.readAsText(t);return e.DataFrame.fromCsv(n)}const u=t=>async()=>{const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i};(0,t.t6)("NegativeStartEnd",(async()=>{await h(["START","END"])})),(0,t.t6)("NegativeStartEndIntermediate",(async()=>{await h(["START","END","INTERMEDIATE"])})),(0,t.t6)("FastaDna1",(async()=>{await f(u("csvFastaDna1"),"seq",l.Hi.FASTA,"SEQ",l.YI.DNA,4,!1)})),(0,t.t6)("FastaRna1",(async()=>{await f(u("fastaRna1"),"seq",l.Hi.FASTA,"SEQ",l.YI.RNA,4,!1)})),(0,t.t6)("FastaPt1",(async()=>{await f(u("fastaPt1"),"seq",l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})),(0,t.t6)("FastaPtGaps",(()=>m(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEYV"],l.Hi.FASTA,"SEQ",l.YI.PT,20,!1))),(0,t.t6)("FastaPtGapsMsa",(()=>m(["FW-PH-EYY","FYNRQWYV-","FKP-Q-SEY"],l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1))),(0,t.t6)("FastaUn",(async()=>{await f(u("fastaUn"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.UN,12,!0)})),(0,t.t6)("FastaMsaDna1",(async()=>{await f(u("fastaMsaDna1"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.DNA,4,!1)})),(0,t.t6)("FastaMsaPt1",(async()=>{await f(u("fastaMsaPt1"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1)})),(0,t.t6)("SepDna",(async()=>{await f(u("sepDna"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.DNA,4,!1,"*")})),(0,t.t6)("SepRna",(async()=>{await f(u("sepRna"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.RNA,4,!1,"*")})),(0,t.t6)("SepPt",(async()=>{await f(u("sepPt"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.PT,20,!1,"-")})),(0,t.t6)("SepUn1",(async()=>{await f(u("sepUn1"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,8,!0,"-")})),(0,t.t6)("SepUn2",(async()=>{await f(u("sepUn2"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,9,!0,"/")})),(0,t.t6)("SepMsaN1",(async()=>{await f(u("sepMsaDna1"),"seq",l.Hi.SEPARATOR,"SEQ.MSA",l.YI.DNA,4,!1,"-")})),(0,t.t6)("SepMsaUnWEmpty",(async()=>{await f(u("sepMsaUnWEmpty"),"seq",l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,14,!0)})),(0,t.t6)("SepComplex",(async()=>{await f(u("sepComplex"),"seq",l.Hi.SEPARATOR,"SEQ",l.YI.UN,18,!0)})),(0,t.t6)("samplesFastaCsv",(async()=>{await g(o("fastaCsv"),{Sequence:new d(l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})})),(0,t.t6)("samplesPeptidesComplex",(async()=>{await g(o("peptidesComplex"),{})})),(0,t.t6)("samplesMsaComplex",(async()=>{await g(o("msaComplex"),{MSA:new d(l.Hi.SEPARATOR,"SEQ.MSA",l.YI.UN,161,!0,"/")})})),(0,t.t6)("samplesIdCsv",(async()=>{await g(o("testIdCsv"),{})})),(0,t.t6)("samplesSarSmallCsv",(async()=>{await g(o("testSmilesCsv"),{})})),(0,t.t6)("samplesHelmCsv",(async()=>{await g(o("helmCsv"),{HELM:new d(l.Hi.HELM,null,null,160,!0)})})),(0,t.t6)("samplesTestHelmCsv",(async()=>{await g(o("testHelmCsv"),{"HELM string":new d(l.Hi.HELM,null,null,9,!0)})})),(0,t.t6)("samplesTestDemogCsv",(async()=>{await g(o("testDemogCsv"),{})})),(0,t.t6)("samplesTestSmiles2Csv",(async()=>{await g(o("testSmiles2Csv"),{})})),(0,t.t6)("samplesTestSmilesShort",(async()=>{await g(o("testSmilesShort"),{})})),(0,t.t6)("samplesTestActivityCliffsNegativeSmiles",(async()=>{await g(o("testActivityCliffsCsv"),{})})),(0,t.t6)("samplesFastaPtCsv",(async()=>{await g(o("fastaPtCsv"),{sequence:new d(l.Hi.FASTA,"SEQ",l.YI.PT,20,!1)})})),(0,t.t6)("samplesTestCerealCsv",(async()=>{await g(o("testCerealCsv"),{})})),(0,t.t6)("samplesTestUnichemSources",(async()=>{await g(o("testUnichemSources"),{})})),(0,t.t6)("samplesTestDmvOffices",(async()=>{await g(o("testDmvOffices"),{})})),(0,t.t6)("samplesTestAlertCollection",(async()=>{await g(o("testAlertCollection"),{})})),(0,t.t6)("samplesTestSpgi",(async()=>{await g(o("testSpgi"),{})})),(0,t.t6)("samplesTestSpgi100",(async()=>{await g(o("testSpgi100"),{})})),(0,t.t6)("samplesTestUrl",(async()=>{await g(o("testUrl"),{})}))})),(0,t.L1)("detectors:weak-and-likely",(()=>{const n={fastaDnaWeak1:"id,colName\n1,TTTTTTTTTT\n2,TTTTTTTTTT\n3,TTTTTTTTTT\n4,TTTTTTTTTT",fastaDnaWeak1LikelyName:"id,seq\n1,TTTTTTT\n2,TTTTTTT\n3,TTTTTTT\n4,TTTTTTT",fastaRnaWeak1:"id,colName\n1,UUUUUUUUUU\n2,UUUUUUUUUU\n3,UUUUUUUUUU\n4,UUUUUUUUUU",fastaRnaWeak1LikelyName:"id,seq\n1,UUUUUUU\n2,UUUUUUU\n3,UUUUUUU\n4,UUUUUUU",fastaPtWeak1:"id,colName\n1,SLSLSPGKSLSLSPGK\n2,SLSLSPGKSLSLSPGK\n3,SLSLSPGKSLSLSPGK\n4,SLSLSPGKSLSLSPGK",fastaPtWeak1LikelyName:"id,seq\n1,SLSLSPGKSLSLSPGK\n2,SLSLSPGKSLSLSPGK\n3,SLSLSPGKSLSLSPGK\n4,SLSLSPGKSLSLSPGK",fastaUn1:"id,colName\n1,word\n2,other\n3,some\n4,another",fastaUn1LikelyName:"id,seq\n1,word\n2,other\n3,some\n4,another",fastaUn2LikelyName:'protein\nBoombastic\nMegafantastic\n"just-a-random-thought,oy!"',fastaUnMsa1LikelyName:"id,seq\n1,word\n2,male\n3,bare\n4,core"},r=t=>async()=>{const r=n[t],i=e.DataFrame.fromCsv(r);return await a.data.detectSemanticTypes(i),i};(0,t.t6)("fastaDnaWeak1",(async()=>{await p(r("fastaDnaWeak1"),"colName")})),(0,t.t6)("fastaDnaWeak1LikelyName",(async()=>{await f(r("fastaDnaWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.DNA,4,!1)})),(0,t.t6)("fastaRnaWeak1",(async()=>{await p(r("fastaRnaWeak1"),"colName")})),(0,t.t6)("fastaRnaWeak1LikelyName",(async()=>{await f(r("fastaRnaWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.RNA,4,!1)})),(0,t.t6)("fastaPtWeak1",(async()=>{await p(r("fastaPtWeak1"),"colName")})),(0,t.t6)("fastaPtWeak1LikelyName",(async()=>{await f(r("fastaPtWeak1LikelyName"),"seq",l.Hi.FASTA,"SEQ.MSA",l.YI.PT,20,!1)})),(0,t.t6)("fastaUn1",(async()=>{await p(r("fastaUn1"),"colName")})),(0,t.t6)("fastaUn1LikelyName",(async()=>{await p(r("fastaUn1LikelyName"),"seq")})),(0,t.t6)("fastaUn2LikelyName",(async()=>{await p(r("fastaUn2LikelyName"),"protein")})),(0,t.t6)("fastaUnMsa1LikelyName",(async()=>{await p(r("fastaUnMsa1LikelyName"),"seq")}))})),(0,t.L1)("detectorsBenchmark",(()=>{let n;async function r(r,s,o,a,c,d){return await async function(r){const h=await(async()=>{const t=function(t,n,r,i,s){let o;switch(t){case l.Hi.FASTA:o=e=>{let t="";for(let n=0;n<e.length;n++){const r=e[n];t+=1==r.length?r:`[${r}]`}return t};break;case l.Hi.SEPARATOR:o=(e,t)=>e.join(t);break;default:throw new Error(`Not supported notation '${t}'.`)}const a=(e,t)=>{const n=new Array(t);for(let r=0;r<t;r++)n[r]=e[Math.floor(Math.random()*e.length)];return o(n,s)},c=Array(i);for(let e=0;e<i;e++)c[e]=a(n,r);return e.Column.fromStrings("seq",c)}(s,[...(0,l.Qf)(o)],a,c,d),r=n.prepare({col:t});return i(r),r})(),p=Date.now(),m=i(h),f=Date.now();(function(e,n){const r=u.GO.forColumn(e);(0,t.E3)(e.semType===n.semType,!0),(0,t.E3)(r.notation===n.notation,!0),(0,t.E3)(r.alphabet===n.alphabet,!0),(0,t.E3)(r.separator===n.separator,!0)})(m,{semType:e.SEMTYPE.MACROMOLECULE,notation:s,alphabet:o,separator:d});const g=f-p;if(g>r){const e=`ET ${g} ms is more than max allowed ${r} ms.`;throw console.error(e),new Error(e)}return console.log(`ET ${g} ms is OK.`),g}(r)}function i(e){e.callSync();const t=e.getOutputParamValue(),n=e.inputs.col;return t&&(n.semType=t),n}(0,t.gM)((async()=>{const t=e.Func.find({package:"Bio",name:"detectMacromolecule"});n=t[0];const r=e.Column.fromStrings("seq",["ACGT","ACGT","ACGT"]);await n.prepare({col:r}).call()})),(0,t.t6)("fastaDnaShorts50Few50",(async()=>{await r(10,l.Hi.FASTA,l.YI.DNA,50,50)})),(0,t.t6)("fastaDnaShorts50Many1E6",(async()=>{await r(20,l.Hi.FASTA,l.YI.DNA,50,1e6)})),(0,t.t6)("fastaDnaLong1e6Few50",(async()=>{await r(20,l.Hi.FASTA,l.YI.DNA,1e6,50)})),(0,t.t6)("separatorDnaShorts50Few50",(async()=>{await r(10,l.Hi.SEPARATOR,l.YI.DNA,50,50,"/")})),(0,t.t6)("separatorDnaShorts50Many1E6",(async()=>{await r(20,l.Hi.SEPARATOR,l.YI.DNA,50,1e6,"/")})),(0,t.t6)("separatorDnaLong1e6Few50",(async()=>{await r(20,l.Hi.SEPARATOR,l.YI.DNA,1e6,50,"/")}))}));var y=n(608),w=n(1619),b=n(6740);async function v(n,r){const i=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(i);const s=e.DataFrame.fromCsv(r),o=i.getCol("seq");(0,t.E3)(o.semType,e.SEMTYPE.MACROMOLECULE);const c=s.getCol("seq"),l=await(0,y.eE)(o,!0);(0,t.J6)(l.toList(),c.toList())}async function A(n,r,i,s,o,c){const u=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(u);const d=e.DataFrame.fromCsv(r).getCol("seq"),h=u.getCol("seq");(0,t.E3)(h.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(h.meta.units,i),o&&(0,t.E3)(h.getTag(l.gp.alphabet),o);const p=await(0,w.D)({col:h,pepsea:{method:c}});(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(p.meta.units,s),(0,t.E3)(p.getTag(l.gp.aligned),"SEQ.MSA"),o&&(0,t.E3)(p.getTag(l.gp.alphabet),o),(0,t.J6)(p.toList(),d.toList())}(0,t.L1)("MSA",(async()=>{(0,t.t6)("isCorrect",(async()=>{await v("seq\nFWRWYVKHP\nYNRWYVKHP\nMWRSWYCKHP","seq\nFWR-WYVKHP\nYNR-WYVKHP\nMWRSWYCKHP")})),(0,t.t6)("isCorrectLong",(async()=>{await v("seq\nFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP","seq\nFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHPFWR-WYVKHP\nYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHPYNR-WYVKHP\nMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHPMWRSWYCKHP")})),(0,t.t6)("isCorrectHelm",(async()=>{await(0,b.m8)(),await A("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2}$$$$\n PEPTIDE1{meI.Aca.N.T.dE.Thr_PO3H2}$$$$\n PEPTIDE1{hHis.Aca.N.T.dE.Thr_PO3H2}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2\n .meI.Aca.N.T.dE.Thr_PO3H2\n .hHis.Aca.N.T.dE.Thr_PO3H2",l.Hi.HELM,l.Hi.SEPARATOR,void 0,"mafft")}),{timeout:6e4}),(0,t.t6)("isCorrectHelmLong",(async()=>{await(0,b.m8)(),await A("seq\n PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2}$$$$\n PEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\n PEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$","seq\n meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.dV.E.N.D-Orn.D-aThr.Phe_4Me.Thr_PO3H2\n meI.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me.\n Lys_Boc.hHis.Aca.Cys_SEt.T.dK..Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me.",l.Hi.HELM,l.Hi.SEPARATOR,void 0,"mafft")}),{timeout:6e4}),(0,t.t6)("isCorrectSeparator",(async()=>{await A("seq\n F-W-P-H-E-Y\n Y-N-R-Q-W-Y-V\n M-K-P-S-E-Y-V","seq\n FWPHEY-\n YNRQWYV\n MKPSEYV",l.Hi.SEPARATOR,l.Hi.FASTA,l.YI.PT)})),(0,t.t6)("isCorrectSeparatorLong",(async()=>{await A("seq\n M-I-E-V-F-L-F-G-I-V-L-G-L-I-P-I-T-L-A-G-L-F-V-T-A-Y-L-Q-Y-R-R-G-D-Q-L-D-L\n M-M-E-L-V-L-K-T-I-I-G-P-I-V-V-G-V-V-L-R-I-V-D-K-W-L-N-K-D-K\n M-D-R-T-D-E-V-S-N-H-T-H-D-K-P-T-L-T-W-F-E-E-I-F-E-E-Y-H-S-P-F-H-N","seq\n MIEV-FLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n MMEL-VLKTII-GPIVVGVVLRIVDKWLNKDK------\n MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN-----",l.Hi.SEPARATOR,l.Hi.FASTA,l.YI.PT)}))}));var E=n(1991),C=n.n(E),T=n(5785),S=n(6642);async function _(t){const n=await async function(e){return await _e.files.readAsText(e)}(t),r=e.DataFrame.fromCsv(n);return r.name=t.replace(".csv",""),r}async function P(e,n=5e3){await(0,t.cb)(0),await(0,t.PE)(e.onAfterDrawContent,(()=>{}),(()=>{e.invalidate()}),n);const r=e.columns.length;for(let t=0;t<r;++t){const n=e.columns.byIndex(t);if(n){const t=e.cell(n.name,0),[r,o,a]=(0,S.h)(t),c=(void 0,(s=i=a.rendererBack)&&void 0!==s.onRendered&&void 0!==s.invalidate&&void 0!==s.awaitRendered?i:null);c&&await c.awaitRendered()}}var i,s}var x=n(4139),M=n(9322);async function $(e,n){const r=(0,l.J9)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(r)} .`),(0,t.J6)(C()(r.originals).toArray(),n)}async function N(e,n){const r=(0,M.qp)(e);console.debug(`Bio: tests: splitters: src=${JSON.stringify(e)}, res=${JSON.stringify(r)} .`),(0,t.J6)(C()(r.originals).toArray(),n)}(0,t.L1)("splitters",(async()=>{(0,t.gM)((async()=>{})),(0,t.Pl)((async()=>{}));const n=["M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",["M","MeI","Y","K","E","T","L","L","MeF","P","K","T","D","F","P","M","R","G","G","L","MeA"]],r=["[meI][Pip][dK][Thr_PO3H2][L-hArg(Et,Et)][D-Tyr_Et][Tyr_ab-dehydroMe][dV]EN[D-Orn][D-aThr][Phe_4Me]",["meI","Pip","dK","Thr_PO3H2","L-hArg(Et,Et)","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],i=["PEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Tyr_ab-dehydroMe","dV","E","N","D-Orn","D-aThr","Phe_4Me"]],s=["PEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.D-Dap.dV.E.N.pnG.Phe_4Me}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],o=["PEPTIDE1{[meI].[hHis].[Aca].N.T.[dK].[Thr_PO3H2].[Aca].[D-Tyr_Et].[D-Dap].[dV].E.N.[pnG].[Phe_4Me]}$$$",["meI","hHis","Aca","N","T","dK","Thr_PO3H2","Aca","D-Tyr_Et","D-Dap","dV","E","N","pnG","Phe_4Me"]],u=["RNA1{R(U)P.R(T)P.R(G)P.R(C)P.R(A)}$$$$",["R(U)P","R(T)P","R(G)P","R(C)P","R(A)"]],d=["RNA1{P.R(U)P.R(T)}$$$$",["P","R(U)P","R(T)"]],h=["RNA1{P.R(U).P.R(T)}$$$$",["P","R(U)","P","R(T)"]];(0,t.t6)("fastaMulti",(async()=>{await $(n[0],n[1])})),(0,t.t6)("fastaFromHelm",(async()=>{await $(r[0],r[1])})),(0,t.t6)("helm1",(async()=>{await N(i[0],i[1])})),(0,t.t6)("helm2",(async()=>{await N(s[0],s[1])})),(0,t.t6)("helm3-multichar",(async()=>{await N(o[0],o[1])})),(0,t.t6)("testHelm1",(async()=>{await N(u[0],u[1])})),(0,t.t6)("testHelm2",(async()=>{await N(d[0],d[1])})),(0,t.t6)("testHelm3",(async()=>{await N(h[0],h[1])})),(0,t.t6)("splitToMonomers",(async()=>{const e=await a.dapi.files.readCsv("System:AppData/Bio/samples/MSA.csv"),n=e.getCol("MSA"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r),n.setTag(l.gp.aligned,x.gN);const i=await(0,T.k)(e,n);(0,t.E3)(i.columns.names().includes("17"),!0),await a.data.detectSemanticTypes(i);const s=a.shell.addTableView(i);await P(s.grid),(0,t.E3)(s.grid.dataFrame.id,e.id)})),(0,t.t6)("getHelmMonomers",(async()=>{const t=e.DataFrame.fromCsv("HELM,Activity\nPEPTIDE1{hHis.N.T}$$$,5.30751\nPEPTIDE1{hHis.Aca.Cys_SEt}$$$,5.72388\n");await a.data.detectSemanticTypes(t);const n=["hHis","Aca","Cys_SEt","N","T"],r=t.getCol("HELM"),i=(0,c.getHelmMonomers)(r),s=n.filter((e=>!i.includes(e))),o=i.filter((e=>!n.includes(e)));if(s.length>0||o.length){const e=[];throw s.length>0&&e.push(`Missed monomers ${JSON.stringify(s)}.`),o.length>0&&e.push(`Unexpected monomers ${JSON.stringify(o)}.`),new Error(e.join(" "))}}))}));var L=n(6718),I=n(4356);const R={PEPTIDE:324,RNA:383,CHEM:0};(0,t.L1)("monomerLibraries",(()=>{let e,n=null;(0,t.gM)((async()=>{e=await(0,L.pj)(),n=(0,I.ub)()})),(0,t.Pl)((async()=>{await(0,I.Eu)(n)})),(0,t.t6)("default",(async()=>{await(0,I.Eu)({exclude:[],explicit:[],duplicateMonomerPreferences:{}}),await e.loadLibraries(!0);const n=e.getMonomerLib();(0,t.E3)(n.getPolymerTypes().length>0,!0)})),(0,t.t6)("forTests",(async()=>{await(0,I.yZ)(),await e.loadMonomerLib(!0),function(e){const n=R,r=e.getSummaryObj();for(const e in n)n[e]||delete n[e];for(const e in r)r[e]||delete r[e];if(0==Object.keys(n).length&&0!=Object.keys(r).length)throw new Error("Expected empty monomer lib, actual is not.");if(0!=Object.keys(n).length&&0==Object.keys(r).length)throw new Error("Expected non-empty monomer lib, actual is empty.");try{(0,t.Xk)(r,n),(0,t.Xk)(n,r)}catch(e){throw new Error(`Expected monomer lib ${JSON.stringify(n)} does not match actual ${JSON.stringify(r)}.`)}}(e.getMonomerLib())})),(0,t.t6)("empty",(async()=>{const n=await(0,I.ub)(),r=await e.getFileManager();let i=r.getValidLibraryPaths();0===i.length&&(i=await r.getValidLibraryPathsAsynchronously()),n.exclude=i,n.explicit=[],await(0,I.Eu)(n),await e.loadMonomerLib(!0);const s=e.getMonomerLib().getPolymerTypes();(0,t.E3)(0===s.length,!0)}))}));var O=n(7389),k=n(1757),G=n.n(k),H=n(1858),D=n(6873),F=n(5433);async function U(n,r){const i=n(),s=e.DataFrame.fromColumns(i);await a.data.detectSemanticTypes(s);const o=Date.now(),c=(s.columns.byName("MSA"),a.shell.addTableView(s));await P(c.grid),(0,t.E3)(c.grid.dataFrame.id,s.id);const l=Date.now()-o;console.log(`Performance test: ${r}: ${l}ms`)}(0,t.L1)("renderers",(()=>{(0,t.t6)("long sequence performance ",(async()=>{await U(D.dW,"Long sequences")})),(0,t.t6)("many sequence performance",(async()=>{await U(D.fD,"Many sequences")})),(0,t.t6)("rendererMacromoleculeFasta",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("Sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeSeparator",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/SEPARATOR_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const c=i.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(c,"sequence")}()})),(0,t.t6)("rendererMacromoleculeDifference",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=x.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),await P(i.grid),(0,t.E3)(i.grid.dataFrame.id,r.id);const s=n.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(s,x.uF.MACROMOLECULE_DIFFERENCE)}()})),(0,t.t6)("afterMsa",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA.fasta"),r=(0,c.importFasta)(n)[0],i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r),console.log("Bio: tests/renderers/afterMsa, table view"),await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),console.log(`Bio: tests/renderers/afterMsa, src before test semType="${i.semType}", units="${i.meta.units}", cell.renderer="${i.getTag(e.TAGS.CELL_RENDERER)}"`),(0,t.E3)(i.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(i.meta.units,l.Hi.FASTA),(0,t.E3)(i.getTag(l.gp.aligned),"SEQ"),(0,t.E3)(i.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(i.getTag(e.TAGS.CELL_RENDERER),"sequence");const d=await(0,w.D)({col:i});await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id),(0,t.E3)(d.semType,e.SEMTYPE.MACROMOLECULE),(0,t.E3)(d.meta.units,l.Hi.FASTA),(0,t.E3)(d.getTag(l.gp.aligned),"SEQ.MSA"),(0,t.E3)(d.getTag(l.gp.alphabet),l.YI.PT),(0,t.E3)(d.getTag(e.TAGS.CELL_RENDERER),"sequence"),u.GO.forColumn(d)}()})),(0,t.t6)("afterConvert",(async()=>{await async function(){const n=await a.dapi.files.readAsText("System:AppData/Bio/samples/FASTA_PT.csv"),r=e.DataFrame.fromCsv(n),i=r.getCol("sequence"),s=await a.functions.call("Bio:detectMacromolecule",{col:i});s&&(i.semType=s);const o=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const c=await(0,F.r)(i,l.Hi.SEPARATOR,"/");await P(o.grid),(0,t.E3)(o.grid.dataFrame.id,r.id);const d=c.getTag(e.TAGS.CELL_RENDERER);(0,t.E3)(d,"sequence"),u.GO.forColumn(c)}()})),(0,t.t6)("afterConvertToHelm",(async()=>{await async function(){const n=await a.dapi.files.readCsv("System:AppData/Bio/samples/FASTA_PT.csv"),r=a.shell.addTableView(n);await P(r.grid);const i=n.getCol("sequence"),s=u.GO.forColumn(i).convert(l.Hi.HELM);n.columns.add(s),await P(r.grid),(0,t.E3)(s.getTag(e.TAGS.CELL_RENDERER),"helm")}()})),(0,t.t6)("selectRendererBySemType",(async()=>{await async function(){const n=e.Column.fromStrings("SequencesDiff",["meI/hHis/Aca/N/T/dK/Thr_PO3H2/Aca#D-Tyr_Et/Tyr_ab-dehydroMe/meN/E/N/dV"]);n.meta.units=l.Hi.SEPARATOR,n.setTag(l.gp.separator,"/"),n.setTag(l.gp.aligned,"SEQ"),n.setTag(l.gp.alphabet,"UN"),n.setTag(l.gp.alphabetIsMultichar,"true"),n.semType=x.uF.MACROMOLECULE_DIFFERENCE;const r=e.DataFrame.fromColumns([n]);a.shell.addTableView(r),await(0,t.cb)(100);const i=n.getTag(e.TAGS.CELL_RENDERER);if("MacromoleculeDifference"!==i)throw new Error(`Units 'separator', separator '/' and semType 'MacromoleculeDifference' have been manually set on column but after df was added as table, view renderer has set to '${i}' instead of correct 'MacromoleculeDifference'.`)}()})),(0,t.t6)("scatterPlotTooltip",(async()=>{await async function(){const r=e.DataFrame.fromCsv(n);r.currentRowIdx=0;const i=a.shell.addTableView(r),s=r.plot.scatter({x:"x",y:"y"});i.dockManager.dock(s,e.DOCK_TYPE.RIGHT,null),await Promise.all([(0,t.PE)(s.onAfterDrawScene,(()=>{}),(()=>{s.invalidateCanvas()}),1e3),P(i.grid,500)]);const o=s.root.getBoundingClientRect(),c=s.worldToScreen(1,0),l=new MouseEvent("mousemove",{cancelable:!0,bubbles:!0,view:window,button:0,clientX:o.left+c.x,clientY:o.top+c.y}),u=G()(s.root).find("canvas").get()[0];await(0,t.PE)((0,H.fromEvent)(u,"mousemove"),(()=>{_e.logger.debug(`Test: event, currentRowIdx=${r.currentRowIdx}`),(0,t.E3)(G()(O.tooltip.root).find("div table.d4-row-tooltip-table tr td canvas").length,1),(0,t.E3)(s.hitTest(c.x,c.y),1)}),(()=>{u.dispatchEvent(l)}),500),await P(i.grid,500)}()}));const n="seq,x,y\nACGGTGTCGT,0,0\nCGGTATCCCT,1,0\nCTCGGCATGC,2,0\n"}));var V=n(6882);(0,t.L1)("renderers: monomerPlacer",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.awaitLoaded(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const i={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:5}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:5}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:297},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(i))(0,t.t6)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const n=t.getCol("seq"),i=new V.J(null,n,_e.logger,3,(()=>({seqHandler:u.GO.forColumn(n),monomerCharWidth:7,separatorWidth:12,monomerToShort:l.zS}))),s=r.testList;for(let e=0;e<n.length;++e)i.getCellMonomerLengths(e,1e4);const o=[];for(const[e,t]of C().enumerate(s)){const t={pos:i.getPosition(e.src.row,e.src.x,1e4)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", \n"))}))})),(0,t.L1)("renderers: monomerPlacer",(()=>{const e=[10,20,30,40,50,60],n={left:{x:3,tgt:null},c0left:{x:10,tgt:0},c0mid:{x:12,tgt:0},c0right:{x:19,tgt:0},c1left:{x:20,tgt:1},c2right:{x:39,tgt:2},c4left:{x:50,tgt:4},c4right:{x:59,tgt:4},max:{x:60,tgt:null},right:{x:65,tgt:null}};for(const[r,i]of Object.entries(n))(0,t.t6)("hitBounds-"+r,(async()=>{const n=(0,V.B)(e,i.x);(0,t.E3)(n,i.tgt)}))})),(0,t.L1)("converters",(()=>{let n;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(n||(n={}));const r={[n.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[n.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[n.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[n.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[n.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[n.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[n.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[n.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[n.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[n.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[n.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[n.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[n.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[n.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[n.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[n.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[n.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[n.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"},i=new Set(Object.values(l.gp));async function s(t){const n=r[t],i=e.DataFrame.fromCsv(n);return await a.data.detectSemanticTypes(i),i}function o(e,n){if(e===l.Hi.SEPARATOR&&!n)throw new Error(`Argument 'separator' is mandatory for target notation '${e.toString()}'.`);return function(r){const i=u.GO.forColumn(r).convert(e,n);return(0,t.E3)(i.meta.units,e),i}}async function c(e,n,r){const o=(await s(e)).getCol("seq"),a=n(o),c=(await s(r)).getCol("seq");(0,t.J6)(a.toList(),c.toList());const d=u.GO.forColumn(o),h=u.GO.forColumn(a);for(const[e,n]of Object.entries(c.tags)){if(!i.has(e)||d.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e)||h.notation===l.Hi.HELM&&[l.gp.alphabet,l.gp.alphabetIsMultichar].includes(e))continue;const r=a.getTag(e);(0,t.E3)(r,n,`Tag '${e}' expected value '${n}' is not equal to actual '${r}'.`)}}(0,t.t6)("testFastaPtToSeparator",(async()=>{await c(n.fastaPt,o(l.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testFastaDnaToSeparator",(async()=>{await c(n.fastaDna,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testFastaRnaToSeparator",(async()=>{await c(n.fastaRna,o(l.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testFastaGapsToSeparator",(async()=>{await c(n.fastaGaps,o(l.Hi.SEPARATOR,"/"),n.separatorGaps)})),(0,t.t6)("testFastaUnToSeparator",(async()=>{await c(n.fastaUn,o(l.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testFastaPtToHelm",(async()=>{await c(n.fastaPt,o(l.Hi.HELM),n.helmPt)})),(0,t.t6)("testFastaDnaToHelm",(async()=>{await c(n.fastaDna,o(l.Hi.HELM),n.helmDna)})),(0,t.t6)("testFastaRnaToHelm",(async()=>{await c(n.fastaRna,o(l.Hi.HELM),n.helmRna)})),(0,t.t6)("testFastaGapsToHelm",(async()=>{await c(n.fastaGaps,o(l.Hi.HELM),n.helmGaps)})),(0,t.t6)("testSeparatorPtToFasta",(async()=>{await c(n.separatorPt,o(l.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testSeparatorDnaToFasta",(async()=>{await c(n.separatorDna,o(l.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testSeparatorRnaToFasta",(async()=>{await c(n.separatorRna,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testSeparatorGapsToFasta",(async()=>{await c(n.separatorGaps,o(l.Hi.FASTA),n.fastaGaps)})),(0,t.t6)("testSeparatorUnToFasta",(async()=>{await c(n.separatorUn,o(l.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testSeparatorPtToHelm",(async()=>{await c(n.separatorPt,o(l.Hi.HELM),n.helmPt)})),(0,t.t6)("testSeparatorDnaToHelm",(async()=>{await c(n.separatorDna,o(l.Hi.HELM),n.helmDna)})),(0,t.t6)("testSeparatorRnaToHelm",(async()=>{await c(n.separatorRna,o(l.Hi.HELM),n.helmRna)})),(0,t.t6)("testSeparatorGapsToHelm",(async()=>{await c(n.separatorGaps,o(l.Hi.HELM),n.helmGaps)})),(0,t.t6)("testHelmDnaToFasta",(async()=>{await c(n.helmDna,o(l.Hi.FASTA),n.fastaDna)})),(0,t.t6)("testHelmRnaToFasta",(async()=>{await c(n.helmRna,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmPtToFasta",(async()=>{await c(n.helmPt,o(l.Hi.FASTA),n.fastaPt)})),(0,t.t6)("testHelmUnToFasta",(async()=>{await c(n.helmUn,o(l.Hi.FASTA),n.fastaUn)})),(0,t.t6)("testHelmDnaToSeparator",(async()=>{await c(n.helmDna,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmRnaToSeparator",(async()=>{await c(n.helmRna,o(l.Hi.SEPARATOR,"*"),n.separatorRna)})),(0,t.t6)("testHelmPtToSeparator",(async()=>{await c(n.helmPt,o(l.Hi.SEPARATOR,"-"),n.separatorPt)})),(0,t.t6)("testHelmUnToSeparator",(async()=>{await c(n.helmUn,o(l.Hi.SEPARATOR,"-"),n.separatorUn)})),(0,t.t6)("testHelmLoneRibose",(async()=>{await c(n.helmLoneRibose,o(l.Hi.FASTA),n.fastaRna)})),(0,t.t6)("testHelmLoneDeoxyribose",(async()=>{await c(n.helmLoneDeoxyribose,o(l.Hi.SEPARATOR,"/"),n.separatorDna)})),(0,t.t6)("testHelmLonePhosphorus",(async()=>{await c(n.helmLonePhosphorus,o(l.Hi.FASTA),n.fastaRna)}))}));var Y=n(3516);(0,t.L1)("fastaFileHandler",(()=>{const n=["description:1","description:2","description:3","description:4"],r=(e.Column.fromStrings("description",n),["MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW","MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL","MMELVLKTIIGPIVVGVVLRIVDKWLNKDK","MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN"]);function i(e){const i=new Y.m(e),s=i.descriptionsArray,o=i.sequencesArray;(0,t.J6)([s,o],[n,r])}(0,t.t6)("testNormalFormatting",(async()=>{i(">description:1\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\n\n>description:3\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n\n>description:4\nMDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN\n")})),(0,t.t6)("testExtraSpaces",(async()=>{i(">description:1\n MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMI EVF LFGIVLGLI PITLAGLFVTAY LQYRRGDQLDL\n\n>description:3\nM MELVLKTI IGPI VVGVVLR IVDKWLNKDK\n\n>description:4\nMDR TDEVSNHTHDKP TLTWFEEIFEEYHSPFHN\n ")})),(0,t.t6)("testExtraNewlines",(async()=>{i(">description:1\n\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\n\n>description:2\nMIEVF\nLFGIVLGLI\nPITLAGLFVTA\nYLQYRRGDQLDL\n\n>description:3\nM\nME\n\nLVLKTIIG\n\nPIVVGVVLRI\nVDKWLNKDK\n\n\n>description:4\n\nMDRT\n\nDEVSNHTHDKP\n\nTLTWFEEIFEE\n\n\n\nYHSPFHN\n")}))}));var B=n(3890);(0,t.L1)("fastaExport",(()=>{let n;!function(e){e.single="single",e.multi="multi"}(n||(n={}));const r={[n.single]:{src:"MDYKETLLMPKTDFPMRGGLP",tgt:["MDYKETLLMP","KTDFPMRGGL","P"]},[n.multi]:{src:"M[MeI]YKETLL[MeF]PKTDFPMRGGL[MeA]",tgt:["M[MeI]YKETLL[MeF]P","KTDFPMRGGL","[MeA]"]}};let i;!function(e){e.test1="test1",e.test2="test2"}(i||(i={}));const s={[i.test1]:{srcCsv:"id,seq\n1,MDYKETLLMP\n2,KTDFPMRGGL\n3,P",idCols:["id"],seqCol:"seq",lineWidth:10,tgtFasta:">1\nMDYKETLLMP\n>2\nKTDFPMRGGL\n>3\nP\n"},[i.test2]:{srcCsv:"id,id2,seq\n1,seqA,M[MeI]YKETLL[MeF]P\n2,seqB,KTDFPMRGGL\n3,seqC,[MeA]\n",idCols:["id2","id"],seqCol:"seq",lineWidth:5,tgtFasta:">seqA|1\nM[MeI]YKE\nTLL[MeF]P\n>seqB|2\nKTDFP\nMRGGL\n>seqC|3\n[MeA]\n"}};function o(n,i=10){const s=r[n].src,o=e.Column.fromStrings("src",[s]);o.semType=e.SEMTYPE.MACROMOLECULE,o.meta.units=l.Hi.FASTA;const a=u.GO.forColumn(o).getSplitted(0),c=(0,B.aS)(a,i),d=r[n].tgt;(0,t.J6)(c,d)}async function a(n){const r=e.DataFrame.fromCsv(n.srcCsv),i=r.getCol(n.seqCol);i.semType=e.SEMTYPE.MACROMOLECULE,i.meta.units=l.Hi.FASTA;const s=n.idCols.map((e=>r.getCol(e))),o=(0,B.wz)(s,i,n.lineWidth);(0,t.E3)(o,n.tgtFasta)}(0,t.t6)("wrapSequenceSingle",(async()=>{o(n.single,10)})),(0,t.t6)("wrapSequenceMulti",(async()=>{o(n.multi,10)})),(0,t.t6)("saveAsFastaTest1",(async()=>{a(s[i.test1])})),(0,t.t6)("saveAsFastaTest2",(async()=>{a(s[i.test2])}))}));var W=n(4152),j=n(2738);const K=j._S;(0,t.L1)("bio",(()=>{const n="seq\nACGTCT\nCAGTGT\nTTCAAC";(0,t.t6)("testGetStatsHelm1",(async()=>{const n=e.DataFrame.fromCsv("seq\nPEPTIDE1{meI}$$$$").getCol("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.HELM;const r=(0,M.vZ)(n,1,l.qp);(0,t.Xk)(r.freq,{meI:1}),(0,t.E3)(r.sameLength,!0)})),(0,t.t6)("testGetStatsN1",(async()=>{await async function(n){const r=e.DataFrame.fromCsv(n).col("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA;const i=(0,M.vZ)(r,5,l.J9);(0,t.Xk)(i.freq,{A:4,C:5,G:3,T:6}),(0,t.E3)(i.sameLength,!0)}(n)})),(0,t.t6)("testGetAlphabetSimilarity",(async()=>{await async function(){const e={A:2041,C:3015,G:3015,T:2048,[K]:1e3},n=new Set(Object.keys(o.Q.Names)),r=(0,l.nq)(e,n);(0,t.E3)(r>.6,!0)}()})),(0,t.t6)("testPickupPaletteN1",(async()=>{await async function(n){const r=e.DataFrame.fromCsv(n).col("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA;const i=(0,l.SM)(r);(0,t.E3)(i instanceof o.A,!0)}(n)})),(0,t.t6)("testPickupPaletteN1e",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nACGTAT\nCAGTTG\nTTCG2C").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof o.A,!0)}()})),(0,t.t6)("testPickupPaletteAA1",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nFWPHEYV\nYNRQWYV\nMKPSEYV").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof i.X,!0)}()})),(0,t.t6)("testPickupPaletteX",(async()=>{await async function(){const n=e.DataFrame.fromCsv("seq\nXZJ{}2\n5Z4733\n3Z6></\n675687").col("seq");n.semType=e.SEMTYPE.MACROMOLECULE,n.meta.units=l.Hi.FASTA;const r=(0,l.SM)(n);(0,t.E3)(r instanceof W.$u,!0)}()}))})),(0,t.L1)("WebLogo.monomerToShort",(()=>{(0,t.t6)("longMonomerSingle",(async()=>{(0,t.E3)((0,l.zS)("S",5),"S")})),(0,t.t6)("longMonomerShort",(async()=>{(0,t.E3)((0,l.zS)("Short",5),"Short")})),(0,t.t6)("longMonomerLong56",(async()=>{(0,t.E3)((0,l.zS)("Long56",6),"Long56")})),(0,t.t6)("longMonomerComplexFirstPartShort",(async()=>{(0,t.E3)((0,l.zS)("Long-long",5),"Long…")})),(0,t.t6)("longMonomerComplexFirstPartLong56",(async()=>{(0,t.E3)((0,l.zS)("Long56-long",6),"Long5…")})),(0,t.t6)("monomerToShort",(async()=>{const e=[["AbC","AbC"],["AbCd","Ab…"],["ABc","ABc"],["ABcd","AB…"],["A_b","A_b"],["A_bc","A…"],["Ab_c","Ab…"],["A1_b","A1…"],["Abc_d","Ab…"],["Abcd_e","Ab…"],["A-b","A-b"],["A-bc","A…"],["Ab-c","Ab…"],["A1-b","A1…"],["Abc-d","Ab…"],["Abcd-e","Ab…"],["A","A"],["Ab","Ab"],["Abc","Abc"],["Ab…","Ab…"],["Abcd","Ab…"],["Abcde","Ab…"]],n=e.map((e=>e[0])),r=e.map((e=>e[1])),i=n.map((e=>(0,l.zS)(e,3)));(0,t.J6)(i,r)}))}));var q=n(8047);const Z=j._S;function z(e,n){(0,t.E3)(e.name,n.name),(0,t.J6)(e.getMonomers(),n.getMonomers());for(const r of e.getMonomers())(0,t.E3)(e.getFreq(r).rowCount,n.getFreq(r).rowCount)}(0,t.L1)("WebLogo-positions",(()=>{const n="seq\nATC-G-TTGC--\nATC-G-TTGC--\n-TC-G-TTGC--\n-TC-GCTTGC--\n-TC-GCTTGC--";(0,t.t6)("allPositions",(async()=>{const r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.DNA),s.setTag(l.gp.aligned,"SEQ.MSA");const o=await r.plot.fromType("WebLogo");await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,u=[new q.Ue(0,"1",{A:new q.Tc(2),[Z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(5)}),new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(3,"4",{[Z]:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[Z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)}),new q.Ue(7,"8",{T:new q.Tc(5)}),new q.Ue(8,"9",{G:new q.Tc(5)}),new q.Ue(9,"10",{C:new q.Tc(5)}),new q.Ue(10,"11",{[Z]:new q.Tc(5)}),new q.Ue(11,"12",{[Z]:new q.Tc(5)})];(0,t.E3)(c.length,u.length);for(let e=0;e<c.length;e++){(0,t.E3)(c[e].name,u[e].name);for(const n of c[e].getMonomers())(0,t.E3)(c[e].getFreq(n).rowCount,u[e].getFreq(n).rowCount)}await o.awaitRendered()})),(0,t.t6)("positions with shrinkEmptyTail option true (filtered)",(async()=>{const n=e.DataFrame.fromCsv("seq\n-TC-G-TTGC--\n-TC-GCTTGC--\n-T--C-GT-\n-T--C-GT-\n-T--C-GT-\n-T--CCGT-"),r=a.shell.addTableView(n),i=n.getCol("seq");i.semType=e.SEMTYPE.MACROMOLECULE,i.meta.units=l.Hi.FASTA,i.setTag(l.gp.alphabet,l.YI.DNA),i.setTag(l.gp.aligned,"SEQ"),n.filter.init((e=>e>2)),n.filter.fireChanged();const s=await n.plot.fromType("WebLogo",{shrinkEmptyTail:!0});await(0,t.PE)(s.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(s.root,e.DOCK_TYPE.DOWN)}),500);const o=s.positions,c=[new q.Ue(0,"1",{[Z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(3)}),new q.Ue(2,"3",{[Z]:new q.Tc(3)}),new q.Ue(3,"4",{[Z]:new q.Tc(3)}),new q.Ue(4,"5",{C:new q.Tc(3)}),new q.Ue(5,"6",{[Z]:new q.Tc(2),C:new q.Tc(1)}),new q.Ue(6,"7",{G:new q.Tc(3)}),new q.Ue(7,"8",{T:new q.Tc(3)}),new q.Ue(8,"9",{[Z]:new q.Tc(3)})];(0,t.E3)(o.length,c.length);for(let e=0;e<o.length;e++){(0,t.E3)(o[e].name,c[e].name);for(const n of o[e].getMonomers())(0,t.E3)(o[e].getFreq(n).rowCount,c[e].getFreq(n).rowCount)}await s.awaitRendered()})),(0,t.t6)("positions with skipEmptyPositions option",(async()=>{const r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.DNA),s.setTag(l.gp.aligned,"SEQ.MSA");const o=await r.plot.fromType("WebLogo",{skipEmptyPositions:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{i.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,u=[new q.Ue(0,"1",{A:new q.Tc(2),[Z]:new q.Tc(3)}),new q.Ue(1,"2",{T:new q.Tc(5)}),new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[Z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)}),new q.Ue(7,"8",{T:new q.Tc(5)}),new q.Ue(8,"9",{G:new q.Tc(5)}),new q.Ue(9,"10",{C:new q.Tc(5)})];(0,t.E3)(c.length,u.length);for(let e=0;e<c.length;e++)z(c[e],u[e]);await o.awaitRendered()})),(0,t.t6)("count sequences for monomer at position",(async()=>{const r=function(t,n,r){const i=e.DataFrame.fromCsv(t),s=i.getCol("seq");return s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=n,s.setTag(l.gp.alphabet,r),s.setTag(l.gp.aligned,"SEQ.MSA"),i}(n,l.Hi.FASTA,l.YI.DNA),i=r.getCol("seq"),s=a.shell.addTableView(r),o=await r.plot.fromType("WebLogo",{startPositionName:"3",endPositionName:"7",skipEmptyPositions:!0});await(0,t.PE)(o.onLayoutCalculated,(()=>{}),(()=>{s.dockManager.dock(o.root,e.DOCK_TYPE.DOWN)}),500);const c=o.positions,d=[new q.Ue(2,"3",{C:new q.Tc(5)}),new q.Ue(4,"5",{G:new q.Tc(5)}),new q.Ue(5,"6",{[Z]:new q.Tc(3),C:new q.Tc(2)}),new q.Ue(6,"7",{T:new q.Tc(5)})];(0,t.E3)(c.length,d.length);for(let e=0;e<c.length;e++)z(c[e],d[e]);const h=c[1],p=u.GO.forColumn(i),m=(0,q.eN)(r,p,r.filter,"G",h);(0,t.E3)(m,5),await o.awaitRendered()})),(0,t.t6)("empty",(async()=>{const n=e.DataFrame.fromColumns([(()=>{const t=e.Column.fromStrings("seq",[]);return t.semType=e.SEMTYPE.MACROMOLECULE,t.meta.units=l.Hi.FASTA,t.setTag(l.gp.alphabet,l.YI.DNA),t})()]),r=a.shell.addTableView(n),i=await n.plot.fromType("WebLogo");await(0,t.PE)(i.onLayoutCalculated,(()=>{}),(()=>{r.dockManager.dock(i.root,e.DOCK_TYPE.DOWN)}),500),i.positions,await i.awaitRendered()}))})),(0,t.L1)("WebLogo-project",(()=>{(0,t.t6)("fasta",(async()=>{const n="Tests.Bio.WebLogo-project.fasta",r=await _e.files.readCsv("tests/filter_FASTA.csv"),i=r.name,s=r.getCol("fasta");await a.data.detectSemanticTypes(r);const o=a.shell.addTableView(r),c=await r.plot.fromType("WebLogo",{sequenceColumnName:s.name});o.dockManager.dock(c),await c.awaitRendered(),await P(o.grid),await async function(t,n,r,i){const s=e.Project.create(),o=r.saveLayout();s.name=t,s.addChild(n),s.addChild(o),await a.dapi.layouts.save(r.saveLayout()),await a.dapi.tables.uploadDataFrame(i),await a.dapi.tables.save(n),await a.dapi.projects.save(s)}(n,r.getTableInfo(),o,r),a.shell.closeAll(),await(0,t.cb)(500),await a.dapi.projects.open(n);const l=a.shell.getTableView(i),u=C()(l.viewers).toArray();(0,t.E3)(u.length,2),(0,t.E3)(u.filter((e=>"Grid"===e.type)).length,1);const d=u.find((e=>"WebLogo"===e.type));(0,t.E3)(!!d,!0),await P(o.grid),await d.awaitRendered()}),{skipReason:"depends on 1.18"})})),(0,t.L1)("WebLogo-layout",(()=>{(0,t.t6)("fasta",(async()=>{const e=await _e.files.readCsv("tests/filter_FASTA.csv"),n=e.getCol("fasta");await a.data.detectSemanticTypes(e);const r=a.shell.addTableView(e),i=await e.plot.fromType("WebLogo",{sequenceColumnName:n.name});r.dockManager.dock(i),await(0,t.cb)(2*q.VN.render),await i.awaitRendered(),await P(r.grid);const s=r.saveLayout();s.toJson(),r.loadLayout(s),await(0,t.cb)(2*q.VN.render),await i.awaitRendered(),await P(r.grid);const o=C()(r.viewers).toArray();(0,t.E3)(o.length,2),(0,t.E3)(o.filter((e=>"Grid"===e.type)).length,1),(0,t.E3)(o.filter((e=>"WebLogo"===e.type)).length,1)}))}));var X=n(966);function J(e,t){let n=null;for(const r of e.viewers)r.type===t&&(n=r);return n}(0,t.L1)("checkInputColumn",(()=>{const n="seq\nseq1,\nseq2,\nseq3,\nseq4";(0,t.t6)("testMsaPos",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA,r.setTag(l.gp.alphabet,l.YI.DNA),r.setTag(l.gp.aligned,"SEQ");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!0)})),(0,t.t6)("testMsaNegHelm",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.HELM,r.setTag(l.gp.alphabetIsMultichar,"true");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!1)})),(0,t.t6)("testMsaNegUN",(async()=>{const r=e.DataFrame.fromCsv(n).getCol("seq");r.semType=e.SEMTYPE.MACROMOLECULE,r.meta.units=l.Hi.FASTA,r.setTag(l.gp.alphabet,"UN"),r.setTag(l.gp.alphabetSize,"11"),r.setTag(l.gp.alphabetIsMultichar,"true"),r.setTag(l.gp.aligned,"SEQ");const[i,s]=(0,X.l)(r,"Test",[l.Hi.FASTA],[l.YI.DNA,l.YI.RNA,l.YI.PT]);(0,t.E3)(i,!1)})),(0,t.t6)("testGetActionFunctionMeta",(async()=>{e.Func.find({package:"Bio",name:"multipleSequenceAlignmentDialog"})[0].inputs.find((e=>"sequence"==e.name))}))})),(0,t.L1)("similarity/diversity",(async()=>{(0,t.t6)("similaritySearchViewer",(async()=>{await async function(){const n=await _e.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n);await a.data.detectSemanticTypes(r);const i=a.shell.addTableView(r),s=i.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const o=await i.dataFrame.plot.fromType("Sequence Similarity Search");let c=!1;if(o.computeCompleted.subscribe((e=>{e&&(c=!0)})),i.dockManager.dock(o,e.DOCK_TYPE.RIGHT,null,"Similarity"),await o.renderPromise,await(0,t.bk)((()=>void 0!==J(i,"Sequence Similarity Search")),"Sequence Similarity Search viewer has not been created",100),!o.initialized)throw new Error("The viewer is not initialized.");if(!o.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!o.beforeRender())throw new Error("The viewer is not able to render.");if(!o.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=o;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Similarity Search viewer grid has not been created",100);(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.scores.get(0),e.FLOAT_NULL),(0,t.E3)(l.idxs.get(0),0),(0,t.E3)(l.molCol.get(0),"D-Tyr_Et/Tyr_ab-dehydroMe/dV/E/N/D-Orn/D-aThr//Phe_4Me"),(0,t.E3)(l.scores.get(1).toFixed(2),"0.73"),(0,t.E3)(l.idxs.get(1),4),(0,t.E3)(l.molCol.get(1),"Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe/dV/Chg/N/D-Orn/D-aThr//Phe_4Me"),i.dataFrame.currentRowIdx=1,await(0,t.bk)((()=>1===l.targetMoleculeIdx),"Target molecule has not been changed",5e3),await(0,t.bk)((()=>"meI/hHis/Aca/Cys_SEt/T/dK/Thr_PO3H2/Aca/Tyr_PO3H2/D-Chg/dV/Phe_ab-dehydro/N/D-Orn/D-aThr//Phe_4Me"===l.molCol.get(0)),"Incorrect first similar molecule",5e3)}()})),(0,t.t6)("diversitySearchViewer",(async()=>{await async function(){const n=await _e.files.readAsText("tests/sample_MSA_data.csv"),r=e.DataFrame.fromCsv(n),i=a.shell.addTableView(r);await a.data.detectSemanticTypes(r);const s=i.dataFrame.getCol("MSA");(0,t.E3)(s.semType,e.SEMTYPE.MACROMOLECULE);const o=await i.dataFrame.plot.fromType("Sequence Diversity Search");let c=!1;if(o.computeCompleted.subscribe((e=>{e&&(c=!0)})),i.dockManager.dock(o,e.DOCK_TYPE.DOWN,null,"Diversity"),await o.renderPromise,await(0,t.bk)((()=>void 0!==J(i,"Sequence Diversity Search")),"Sequence Diversity Search viewer has not been created",100),!o.initialized)throw new Error("The viewer is not initialized.");if(!o.moleculeColumn)throw new Error("The viewer has not molecule column (onTableAttached).");if(!o.beforeRender())throw new Error("The viewer is not able to render.");if(!o.computeRequested)throw new Error("The viewer has not compute requested even.");if(!c)throw new Error("The viewer has not compute completed.");const l=o;await(0,t.bk)((()=>0!==l.root.getElementsByClassName("d4-grid").length),"Sequence Diversity Search viewer grid has not been created",100),(0,t.E3)(l.fingerprint,"Morgan"),(0,t.E3)(l.distanceMetric,"Tanimoto"),(0,t.E3)(l.initialized,!0),(0,t.E3)(l.renderMolIds.length>0,!0)}()}))}));var Q=n(9124),ee=n(1687),te=n(4577);async function ne(e,t){if(!t.columns.names().includes(e))throw new Error(`The column '${e}' not found. Available in data frame are ${JSON.stringify(t.columns.names())}`);const n=new ee._i;return n.attach(t),n.applyState({columnName:e}),n.column=t.col(e),n.columnName=e,n}(0,t.L1)("bio-substructure-filters",(async()=>{let n,r,i;(0,t.gM)((async()=>{n=await(0,Q.b)(),r=await(0,L.pj)(),i=await(0,I.ub)(),await(0,I.yZ)(),await r.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("fasta",(async()=>{const e=await _("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=new ee._i;n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new te.n("MD")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,3),(0,t.E3)(n.dataFrame?.filter.toBinaryString(),"10010000100000")}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("separator",(async()=>{const e=await _("tests/filter_MSA.csv"),n=new ee._i;await a.data.detectSemanticTypes(e),n.attach(e),await n.awaitRendered();try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"SeparatorBioFilter");const r=n.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("/meI")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,0),await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{r.props=new ee.AR("meI-hHis","-")}),5e3,"testEvent onRowsFiltered"),(0,t.E3)(n.dataFrame.filter.trueCount,7),(0,t.E3)(n.dataFrame.filter.get(2),!1)}finally{n.detach()}await n.awaitRendered()})),(0,t.t6)("helm-dialog",(async()=>{const e="Bio tests: substructureFilters/helm-dialog",n=await _("tests/filter_HELM.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n);_e.logger.debug(`${e}, filter attaching.`);const i=new ee._i;i.attach(n);const s=O.dialog("Test filters").add(i.root).show();await i.awaitRendered();try{const s=i.bioFilter;(0,t.E3)(null!==i.bioFilter,!0,"bioFilter is not created"),_e.logger.debug(`${e}, filter 1 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{A.C}$$$$V2.0")}),2e4),_e.logger.debug(`${e}, filter 1 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,1),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"0001"),_e.logger.debug(`${e}, filter 2 change awaiting...`),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{s.props=new te.n("PEPTIDE1{C}$$$$V2.0")}),2e4),await P(r.grid),_e.logger.debug(`${e}, filter 2 changed.`),(0,t.E3)(i.dataFrame.filter.trueCount,2),(0,t.E3)(i.dataFrame.filter.toBinaryString(),"1001")}finally{s.close()}await i.awaitRendered(),await(0,t.cb)(3e3)})),(0,t.t6)("helm-view",(async()=>{const e=await _("tests/filter_HELM.csv");e.getCol("HELM string"),await a.data.detectSemanticTypes(e);const t=a.shell.addTableView(e);t.getFiltersGroup(),await P(t.grid)})),(0,t.t6)("sync-fasta",(async()=>{const e=await _e.files.readCsv("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(e);const n=await ne("fasta",e),r=await ne("fasta",e);await Promise.all([n.awaitRendered(),r.awaitRendered()]);try{(0,t.E3)(!!n.bioFilter,!0),(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(n.bioFilter.type,"FastaBioFilter"),(0,t.E3)(r.bioFilter.type,"FastaBioFilter");const i=n.bioFilter,s=r.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{i.props=new te.n("MD")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,3),await n.awaitRendered(),(0,t.E3)(s.props.substructure,"MD")}finally{n.detach(),r.detach()}await Promise.all([n.awaitRendered(),r.awaitRendered()])})),(0,t.t6)("sync-msa",(async()=>{const e=await _e.files.readCsv("tests/filter_MSA.csv");await a.data.detectSemanticTypes(e);const n="hHis-Aca",r=await ne("MSA",e),i=await ne("MSA",e);await Promise.all([r.awaitRendered(),i.awaitRendered()]);try{(0,t.E3)(!!r.bioFilter,!0),(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(r.bioFilter.type,"SeparatorBioFilter"),(0,t.E3)(i.bioFilter.type,"SeparatorBioFilter");const s=r.bioFilter,o=i.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{s.props=new ee.AR(n,"-")}),1e4,"await onRowsFiltered"),(0,t.E3)(e.filter.trueCount,8),(0,t.E3)(o.props.substructure,n),(0,t.E3)(o.props.separator,"-")}finally{r.detach(),i.detach()}await Promise.all([r.awaitRendered(),i.awaitRendered()])})),(0,t.t6)("sync-helm",(async()=>{const e=await _e.files.readCsv("tests/filter_HELM.csv");await a.data.detectSemanticTypes(e);const n=a.shell.addTableView(e),r="PEPTIDE1{A.C}$$$$V2.0",i=await ne("HELM string",e),s=await ne("HELM string",e),o=O.dialog("Test filters").add(i.root).add(s.root).show();await Promise.all([i.awaitRendered(),s.awaitRendered()]);try{(0,t.E3)(!!i.bioFilter,!0),(0,t.E3)(!!s.bioFilter,!0),(0,t.E3)(i.bioFilter.type,"HelmBioFilter"),(0,t.E3)(s.bioFilter.type,"HelmBioFilter");const o=i.bioFilter,a=s.bioFilter;await(0,t.PE)(e.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(r)}),6e4,"await onRowsFiltered"),await P(n.grid),_e.logger.debug("Bio tests: substructureFilters/sync-helm, before changed event"),await(0,t.cb)(2*i.debounceTime),_e.logger.debug("Bio tests: substructureFilters/sync-helm, after changed event"),(0,t.E3)(e.filter.trueCount,1),await i.awaitRendered(),(0,t.E3)(a.props.substructure,r)}finally{i.detach(),s.detach(),o.close()}await Promise.all([i.awaitRendered(),s.awaitRendered()]),await P(n.grid),await(0,t.cb)(3e3)})),(0,t.t6)("two-columns-fasta",(async()=>{const n=e.DataFrame.fromCsv("id,seq1,seq2,trueSeq1,trueSeq2\n0,CGGCTACGGC,ATTGCATTCG,0,1,\n1,CGGCTGCCGC,ATAGCATTCG,1,1,\n2,CGGCTGCGCC,AATGCATACG,1,0,\n3,CGGCTGCATT,TTTGCATTCG,1,1,\n4,CGGCTGCATT,AAAGCATACG,1,0,\n");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="seq1",s="CGGCTG",o=n.getCol("trueSeq1").toList(),c="seq2",l="GCATT",u=n.getCol("trueSeq2").toList(),d=[{type:"Bio:bioSubstructureFilter",columnName:i},{type:"Bio:bioSubstructureFilter",columnName:c}],h=await n.plot.fromType(e.VIEWER.FILTERS,{filters:d});r.dockManager.dock(h,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid);const p=h.filters[0],m=h.filters[1];(0,t.E3)(p.column.name,i),(0,t.E3)(m.column.name,c);const f=p.bioFilter,g=m.bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n(s)}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n("")}),1e3,"testEvent onRowsFiltered on seq1"),(0,t.E3)(n.filter.trueCount,o.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),o.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n(l)}),1e3,"testEvent onRowsFiltered on seq2"),(0,t.E3)(n.filter.trueCount,u.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),u.map((e=>e.toString())).join("")),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n("")}),1e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n("")}),1e3,"testEvent onRowsFiltered on neither"),(0,t.E3)(n.filter.trueCount,n.rowCount),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{f.props=new te.n(s)}),5e3),await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{g.props=new te.n(l)}),5e3,"testEvent onRowsFiltered on both");const y=C().count(0).take(n.rowCount).map((e=>o[e]*u[e])).toArray();(0,t.E3)(n.filter.trueCount,y.filter((e=>1===e)).length),(0,t.E3)(n.filter.toBinaryString(),y.map((e=>e.toString())).join("")),await Promise.all([p.awaitRendered(),m.awaitRendered(),P(r.grid)])})),(0,t.t6)("reset-fasta",(async()=>{const n=await _("tests/filter_FASTA.csv");await a.data.detectSemanticTypes(n);const r=a.shell.addTableView(n),i="MD",s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}]});r.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid);const o=s.filters[0].bioFilter;await(0,t.PE)(n.onRowsFiltered,(()=>{}),(()=>{o.props=new te.n(i)}),1e3,"testEvent onRowsFiltered"),(0,t.E3)(n.filter.trueCount,3),(0,t.E3)(o.props.substructure,i),(0,t.E3)(o.substructureInput.value,i),G()(s.root).find('i[name="icon-arrow-rotate-left"]')[0].click(),await(0,t.cb)(100),await P(r.grid),(0,t.E3)(o.props.substructure,""),(0,t.E3)(o.substructureInput.value,"")})),(0,t.t6)("reopen",(async()=>{const n=await _e.files.readCsv("tests/filter_FASTA.csv"),r=a.shell.addTableView(n),i=[{type:"Bio:bioSubstructureFilter",columnName:"fasta"}],s=await n.plot.fromType(e.VIEWER.FILTERS,{filters:i});r.dockManager.dock(s,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid),s.close(),await P(r.grid);const o=await n.plot.fromType(e.VIEWER.FILTERS,{filters:i});r.dockManager.dock(o,e.DOCK_TYPE.LEFT),await(0,t.cb)(100),await P(r.grid)}))}));var re=n(5437);class ie{errorList=[];warningList=[];infoList=[];debugList=[];error(e,t,n){this.errorList.push({message:e,params:t,stackTrace:n})}warning(e,t){this.warningList.push({message:e,params:t})}info(e,t){this.infoList.push({message:e,params:t})}debug(e,t){this.debugList.push({message:e,params:t})}}var se=n(9192);(0,t.L1)("PepSeA",(()=>{(0,t.gM)((async()=>{await(0,b.m8)()})),(0,t.t6)("Basic alignment",(async()=>{const n=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.R.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.R.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.N.C}$$$$","F.L.R.G.Y.MeF.Y.W...N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n"PEPTIDE1{F.L.R.G.Y.[MeF].Y.W.S.N.D.C}$$$$","F.L.R.G.Y.MeF.Y.W.S.N.D.C"\n"PEPTIDE1{F.V.R.G.Y.[MeF].Y.W.S.N.C}$$$$","F.V.R.G.Y.MeF.Y.W.S..N.C"\n'),r=await(0,re.GD)(n.getCol("HELM"),"msa(HELM)"),i=n.getCol("MSA");for(let e=0;e<r.length;++e)(0,t.E3)(r.get(e)==i.get(e),!0)}),{timeout:6e4,stressTest:!0}),(0,t.t6)("stderr",(async()=>{const n=new ie,r=e.DataFrame.fromCsv('HELM,MSA\n"PEPTIDE1{F.L.Mis.G.W.[MeF].Y.S.N.N.C}$$$$","F.L.Mis.G.W.MeF.Y..S.N.N.C"\n"PEPTIDE1{F.L.Mis.G.Y.[MeF].Y.W.N.C}$$$$","F.L.Mis.G.Y.MeF.Y...W.N.C"\n"PEPTIDE1{F.G.Y.[MeF].Y.W.S.D.N.C}$$$$","F...G.Y.MeF.Y.W.S.D.N.C"\n'),i=await(0,re.GD)(r.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n),s=r.getCol("MSA");(0,t.J6)(i.toList(),s.toList()),(0,t.E3)(n.warningList[0].message,"Mis not found in Monomer Map\nMeF not found in Monomer Map\n")}),{timeout:6e4,stressTest:!0}),(0,t.t6)("error",(async()=>{const n=new ie;try{const t=e.DataFrame.fromCsv('HELM\n"PEPTIDE1{[NH2].*.A.Q.T.T.Y.K.N.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].M.A.N.T.T.Y.K.N.Y.R.N.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.C.Y.R.R.N.L.L.*.[COOH]}$$$$"\n"PEPTIDE1{[NH2].*.A.N.T.T.Y.K.F.Y.R.R.N.L.L.*.[COOH]}$$$$"\n');await(0,re.GD)(t.getCol("HELM"),"msa(HELM)",void 0,void 0,void 0,void 0,n)}catch(e){const[t,r]=(0,se.AP)(e);n.error(t,void 0,r)}(0,t.E3)(n.errorList[0].message,"PepSeA error: The pair (*,M) couldn't be found in the substitution matrix")}),{skipReason:"GROK-16699"})})),(0,t.L1)("viewers",(()=>{const n=e.Func.find({package:"Bio",tags:["viewer"]}).map((e=>e.friendlyName));for(const e of n)(0,t.t6)(e,(async()=>{const n=await _("samples/FASTA_DNA.csv");await(0,t.Bl)(e,n,{detectSemanticTypes:!0})}),{skipReason:{"Sequence Similarity Search":"GROK-13162","Sequence Diversity Search":"GROK-13162",WebLogo:"GROK-13162",VdRegions:"GROK-13162"}[e]})}));const oe="seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",ae="seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT",ce="seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc-abc1-dfgg\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3-wert-rut12";var le;(0,t.L1)("SeqHandler",(()=>{async function n(t){const n=e.DataFrame.fromCsv(t);await a.data.detectSemanticTypes(n);const r=u.GO.forColumn(n.getCol("seq"));return[n,r]}(0,t.t6)("Seq-Fasta",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA",(async()=>{const[e,r]=await n(ae);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!0)})),(0,t.t6)("Seq-Fasta-units",(async()=>{const[e,r]=await n(oe);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!1)})),(0,t.t6)("Seq-Fasta-MSA-units",(async()=>{const[e,r]=await n(ae);(0,t.E3)(r.notation,l.Hi.FASTA),(0,t.E3)(r.isMsa(),!0)})),(0,t.t6)("Seq-Helm",(async()=>{const[e,r]=await n("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Phe_ab-dehydro.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.D-Chg.dV.Thr_PO3H2.N.D-Orn.D-aThr.Phe_4Me}$$$$");(0,t.E3)(r.notation,l.Hi.HELM),(0,t.E3)(r.isHelm(),!0)})),(0,t.t6)("Seq-UN",(async()=>{const[e,r]=await n(ce);(0,t.E3)(r.notation,l.Hi.SEPARATOR),(0,t.E3)(r.separator,"-"),(0,t.E3)(r.alphabet,l.YI.UN)})),(0,t.t6)("Seq-UN-auto",(async()=>{const[e,r]=await n(ce);(0,t.E3)(r.notation,l.Hi.SEPARATOR),(0,t.E3)(r.separator,"-"),(0,t.E3)(r.alphabet,l.YI.UN)})),(0,t.t6)("column-version",(async()=>{const n=e.DataFrame.fromCsv(oe);await a.data.detectSemanticTypes(n);const r=n.getCol("seq"),i=u.GO.forColumn(r),s=r.version,o=u.GO.forColumn(r),c=r.version;(0,t.E3)(s,c,"Unexpected column version changed"),(0,t.E3)(i,o,"Unexpected SeqHandler object changed"),n.rows.addNew(["TACCCCTTCAAC"]);const l=u.GO.forColumn(r),d=r.version;(0,t.E3)(c<d,!0,"Stalled column version on add row"),(0,t.E3)(o!==l,!0,"Stalled SeqHandler object on add row"),r.set(1,"CAGTGTCCCCGT");const h=u.GO.forColumn(r),p=r.version;(0,t.E3)(d<p,!0,"Stalled column version on change data"),(0,t.E3)(l!==h,!0,"Stalled SeqHandler object on change data"),r.setTag("testTag","testValue");const m=u.GO.forColumn(r),f=r.version;(0,t.E3)(p<f,!0,"Stalled column version on set tag"),(0,t.E3)(h!==m,!0,"Stalled SeqHandler object on set tag")}))})),function(e){e.fasta="fasta",e.fastaMsa="fastaMsa",e.separator="separator",e.separatorMsa="separatorMsa",e.helm="helm"}(le||(le={})),(0,t.L1)("SeqHandler",(()=>{u.b9[l.Hi.FASTA],u.b9[l.Hi.HELM];const n=u.b9[l.Hi.SEPARATOR],r={[le.fasta]:{src:{csv:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC"},tgt:{notation:l.Hi.FASTA,splitted:[["A","C","G","T","C","A","C","G","T","C"],["C","A","G","T","G","T","C","A","G","T","G","T"],["T","T","C","A","A","C","T","T","C","A","A","C"]]}},[le.fastaMsa]:{src:{csv:"seq\nAC-GT-CTAC-GT-CT\nCAC-T-GTCAC-T-GT\nACCGTACTACCGTACT"},tgt:{notation:l.Hi.FASTA,splitted:[["A","C","-","G","T","-","C","T","A","C","-","G","T","-","C","T"],["C","A","C","-","T","-","G","T","C","A","C","-","T","-","G","T"],["A","C","C","G","T","A","C","T","A","C","C","G","T","A","C","T"]]}},[le.separator]:{src:{csv:"seq\nabc-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut12-her2-rty-wert-abc-abc1-dfgg-rut12-her2-rty-wert-abc\nrut12-rty-her2-abc-cfr3-wert-rut12-rut12-rty-her2-abc-cfr3"},tgt:{notation:l.Hi.SEPARATOR,separator:"-",splitted:[["abc","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut12","her2","rty","wert","abc","abc1","dfgg","rut12","her2","rty","wert","abc"],["rut12","rty","her2","abc","cfr3","wert","rut12","rut12","rty","her2","abc","cfr3"]]}},[le.separatorMsa]:{src:{csv:'seq\nrut0-dfgg-abc1-cfr3-rty-wert-abc-dfgg-abc1-cfr3-rty-wert\nrut1-her2-rty--abc1-dfgg-rut12-her2-rty--abc1-dfgg\nrut2-rty-her2---wert-rut12-rty-her2---wert\n"rut3-rty-her2-""-""-""-""-wert-rut12-rty-her2-""-""-""-""-wert"\n"""-""-rut4-her2-wert-rut12-rty-her2-wert"\n"rut5-rty-her2-wert-rut12-rty-her2-wert-""-"""'},tgt:{notation:l.Hi.SEPARATOR,separator:"-",splitted:[["rut0","dfgg","abc1","cfr3","rty","wert","abc","dfgg","abc1","cfr3","rty","wert"],["rut1","her2","rty",n,"abc1","dfgg","rut12","her2","rty",n,"abc1","dfgg"],["rut2","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],["rut3","rty","her2",n,n,"wert","rut12","rty","her2",n,n,"wert"],[n,"rut4","her2","wert","rut12","rty","her2","wert"],["rut5","rty","her2","wert","rut12","rty","her2","wert",n]]}},[le.helm]:{src:{csv:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D-Tyr_Et.Thr_PO3H2.Aca.D-Tyr_Et}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.dK.Thr_PO3H2.Aca}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.T.dK.Thr_PO3H2}$$$$"},tgt:{notation:l.Hi.HELM,splitted:[["meI","hHis","Aca","N","T","dE","Thr_PO3H2","Aca","D-Tyr_Et","Thr_PO3H2","Aca","D-Tyr_Et"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["Lys_Boc","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","Aca","dK","Thr_PO3H2","Aca"],["meI","hHis","Aca","Cys_SEt","T","dK","Thr_PO3H2","T","dK","Thr_PO3H2"]]}}};for(const[n,i]of Object.entries(r))(0,t.t6)(`splitted-${n}`,(async()=>{const n=e.DataFrame.fromCsv(i.src.csv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r),(0,t.E3)(n.semType,e.SEMTYPE.MACROMOLECULE);const s=u.GO.forColumn(n);(0,t.E3)(s.notation,i.tgt.notation),(0,t.E3)(s.separator===i.tgt.separator,!0);const o=C().count(0).take(s.length).map((e=>C()(s.getSplitted(e).originals).toArray())).toArray();(0,t.J6)(o,i.tgt.splitted)}))})),(0,t.L1)("SeqHandler: getRegion",(()=>{const n={fastaDna:{srcCsv:"seq\nATTCGT\nACTGCTC\nATTCCGTA",startIdx:2,endIdx:4,tgtCsv:"seq\nTCG\nTGC\nTCC",units:l.Hi.FASTA,alphabet:l.YI.DNA,positionNames:{tag:"a, b, c, d, e, f, g, h",start:"c",end:"e"}},separatorPt:{srcCsv:"seq\nM-D-Y-K-E-T-L\nM-I-E-V-F-L-F-G-I\nM-M-",startIdx:5,endIdx:null,tgtCsv:"seq\nT-L--\nL-F-G-I\n---",units:l.Hi.SEPARATOR,alphabet:l.YI.PT,positionNames:{tag:"1, 1A, 1B, 2, 3, 4, 4A, 4A, 4C",start:"4",end:null}},helm:{srcCsv:"seq\nPEPTIDE1{[meI].[hHis].[Aca].N.T.[dE].[Thr_PO3H2].[Aca].[D-Tyr_Et].[Tyr_ab-dehydroMe].[dV].E.N.[D-Orn]}$$$$\nPEPTIDE1{[meI].[hHis].[Aca].[Cys_SEt].T.[dK].[Thr_PO3H2].[Aca].[Tyr_PO3H2].[D-Chg].[dV].[Phe_ab-dehydro]}$$$$\nPEPTIDE1{[Lys_Boc].[hHis].[Aca].[Cys_SEt].T}$$$$",startIdx:3,endIdx:6,tgtCsv:"seq\nPEPTIDE1{N.T.[dE].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.[dK].[Thr_PO3H2]}$$$$\nPEPTIDE1{[Cys_SEt].T.*.*}$$$$",units:l.Hi.HELM,alphabet:null,positionNames:{tag:null,start:"4",end:"7"}}};for(const[r,i]of Object.entries(n))(0,t.t6)(`${r}-idx`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=u.GO.forColumn(n).getRegion(i.startIdx,i.endIdx,"regSeq"),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(l.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(l.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())})),i.positionNames&&(0,t.t6)(`${r}-positionNames`,(async()=>{const n=e.DataFrame.fromCsv(i.srcCsv).getCol("seq");i.positionNames.tag&&n.setTag(l.gp.positionNames,i.positionNames.tag);const r=await a.functions.call("Bio:detectMacromolecule",{col:n});r&&(n.semType=r);const s=await a.functions.call("Bio:getRegion",{sequence:n,start:i.positionNames.start,end:i.positionNames.end}),o=e.DataFrame.fromCsv(i.tgtCsv).getCol("seq");(0,t.E3)(n.meta.units,i.units),(0,t.E3)(s.meta.units,i.units),(0,t.E3)(n.getTag(l.gp.alphabet),i.alphabet),(0,t.E3)(s.getTag(l.gp.alphabet),i.alphabet),(0,t.J6)(s.toList(),o.toList())}))})),(0,t.L1)("SeqHandler: getHelm",(()=>{let n,r;(0,t.gM)((async()=>{n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const i={fasta:{src:{seq:"MDYKETMDYKET",notation:l.Hi.FASTA},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},separator:{src:{seq:"M-D-Y-K-E-T-M-D-Y-K-E-T",notation:l.Hi.SEPARATOR,separator:"-"},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T.M.D.Y.K.E.T}$$$$"}},helm:{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$$$$",notation:l.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$$$$"}},"helm-cyclic":{src:{seq:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0",notation:l.Hi.HELM},tgt:{helm:"PEPTIDE1{M.D.Y.K.E.T}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$V2.0"}}};for(const[e,n]of Object.entries(i))(0,t.t6)(e,(async()=>{await s(n.src.seq,n.src.notation,n.src.separator,n.tgt.helm)}));async function s(n,r,i,s){const o=e.Column.fromStrings("seq",[n]),c=e.DataFrame.fromColumns([o]);await a.data.detectSemanticTypes(c);const l=u.GO.forColumn(o),d=await l.getHelm(0,!1);(0,t.E3)(d,s)}}));var ue=n(7384),de=n(6717);const he=new e.FileSource("System:AppData/Bio"),pe={"peptides-fasta":{inPath:"tests/to-atomic-level-peptides-fasta-input.csv",outPath:"tests/to-atomic-level-peptides-fasta-output.csv"},"dna-fasta":{inPath:"tests/to-atomic-level-dna-fasta-input.csv",outPath:"tests/to-atomic-level-dna-fasta-output.csv"},"msa-separator":{inPath:"tests/to-atomic-level-msa-separator-input.csv",outPath:"tests/to-atomic-level-msa-separator-output.csv"},"msa-fasta":{inPath:"tests/to-atomic-level-msa-fasta-input.csv",outPath:"tests/to-atomic-level-msa-fasta-output.csv"}},me="molfile(sequence)";async function fe(e,t="seq",n){await(0,de.j)();const r=e.getCol(t),i=n.getMonomerLib(),s=await(0,ue.C4)(e,r,i);return s.warnings.length>0&&_e.logger.warning(`_toAtomicLevel() warnings ${s.warnings.join("\n")}`),s.col}function ge(e){return e.replaceAll("\r\n","\n").replace(/\n$/,"").split("\n").map((e=>e.trimEnd())).join("\n")}(0,t.L1)("toAtomicLevel",(async()=>{const n={},r={};let i,s,o;async function d(e,n){const r=e.getCol("sequence");await(0,c.toAtomicLevel)(e,r,!1);const i=e.getCol(me),s=n.getCol(me),o=C()(i.values()).map((e=>ge(e))).toArray(),a=C()(s.values()).map((e=>ge(e))).toArray();(0,t.J6)(o,a)}(0,t.gM)((async()=>{i=await(0,L.pj)(),s=await(0,I.ub)(),await(0,I.yZ)(),await i.loadMonomerLib(!0);for(const[t,i]of Object.entries(pe))i.inPath,n[t]=e.DataFrame.fromCsv((await he.readAsText(i.inPath)).replace(/\n$/,"")),await a.data.detectSemanticTypes(n[t]),r[t]=e.DataFrame.fromCsv((await he.readAsText(i.outPath)).replace(/\n$/,""))})),(0,t.Pl)((async()=>{await(0,I.Eu)(s),await i.loadMonomerLib(!0)}));for(const[e,i]of Object.entries(pe))(0,t.t6)(`${e}`,(async()=>{await d(n[e],r[e])}));!function(e){e.fastaDna="fastaDna",e.fastaRna="fastaRna",e.fastaPt="fastaPt",e.fastaUn="fastaUn",e.separatorDna="separatorDna",e.separatorRna="separatorRna",e.separatorPt="separatorPt",e.separatorUn="separatorUn",e.helm="helm"}(o||(o={}));const h={[o.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[o.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[o.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[o.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]",[o.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[o.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[o.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[o.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2",[o.helm]:"seq\nPEPTIDE1{meI.D-gGlu.Aca.N.T.dE.Thr_PO3H2.Aca.D.Thr_PO3H2.Aca.D}$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Thr_PO3H2.Aca.Tyr_PO3H2}$$$"};async function p(t){const n=h[t],r=e.DataFrame.fromCsv(n.replace(/\n$/,""));return await a.data.detectSemanticTypes(r),r}(0,t.t6)("fastaDna",(async()=>{await fe(await p(o.fastaDna),"seq",i)})),(0,t.t6)("fastaRna",(async()=>{await fe(await p(o.fastaRna),"seq",i)})),(0,t.t6)("fastaPt",(async()=>{await fe(await p(o.fastaPt),"seq",i)})),(0,t.t6)("fastaUn",(async()=>{await fe(await p(o.fastaUn),"seq",i)})),(0,t.t6)("separatorDna",(async()=>{await fe(await p(o.separatorDna),"seq",i)})),(0,t.t6)("separatorDna",(async()=>{await fe(await p(o.separatorRna),"seq",i)})),(0,t.t6)("separatorPt",(async()=>{await fe(await p(o.separatorPt),"seq",i)})),(0,t.t6)("separatorUn",(async()=>{await fe(await p(o.separatorUn),"seq",i)})),(0,t.t6)("helm",(async()=>{await fe(await p(o.helm),"seq",i)})),(0,t.t6)("ptFasta2",(async()=>{const n=await _e.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),r=e.DataFrame.fromCsv("seq\nAR"),s=r.getCol("seq");s.semType=e.SEMTYPE.MACROMOLECULE,s.meta.units=l.Hi.FASTA,s.setTag(l.gp.alphabet,l.YI.PT),u.GO.forColumn(s);const o=await fe(r,"seq",i);(0,t.E3)(ge(o.get(0)),ge(n))}))}));var ye=n(8754);(0,t.L1)("toAtomicLevel-ui",(()=>{let n,r,i;(0,t.gM)((async()=>{i=await(0,Q.b)(),n=await(0,L.pj)(),r=await(0,I.ub)(),await(0,I.yZ)(),await n.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(r),await n.loadMonomerLib(!0)}));const s="seq\nMDYKETLLMPKTDFPMRGGLPNKEPQIQEKW\nMIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL\nMMELVLKTIIGPIVVGVVLRIVDKWLNKDK\n";async function o(r,i,s){const o=await(0,ye.V)(r,i,s,n.getMonomerLib());(0,t.E3)(o.semType,e.SEMTYPE.MOLECULE)}(0,t.t6)("toAtomicLevel-fasta-linear",(async()=>{const t=e.DataFrame.fromCsv(s);await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!1)})),(0,t.t6)("toAtomicLevel-fasta-nonlinear",(async()=>{const t=e.DataFrame.fromCsv(s);await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!0)})),(0,t.t6)("toAtomicLevel-helm",(async()=>{const t=e.DataFrame.fromCsv("seq\nPEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.Aze.dV.E.N.dV.Phe_4Me}$$$$\nPEPTIDE1{meI.hHis.Aca.N.T.dK.Thr_PO3H2.Aca.meM.D-Chg.dV.E.N.D-Orn.D-aThr.Phe_4Me}$$$$\nPEPTIDE1{meI.Aca.N.T.dK.Thr_PO3H2.Aca.D-Tyr_Et.Tyr_ab-dehydroMe.dV.D-Cit.N.D-Orn.D-aThr.Phe_4Me}$$$$\n");await a.data.detectSemanticTypes(t);const n=t.getCol("seq");await o(t,n,!0)}))}));var we=n(6863);async function be(t){const n=e.DataFrame.fromCsv(t),r=n.col("seq"),i=await a.functions.call("Bio:detectMacromolecule",{col:r});return i&&(r.semType=i),await a.data.detectSemanticTypes(n),u.GO.forColumn(r)}function ve(e,n,r,i){const s=r(e,n);(0,t.E3)(Number(s.toFixed(3)),Number(i.toFixed(3)))}(0,t.L1)("Distance",(async()=>{const n=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],r={F:0,W:1,R:2,Y:3},i="FWRWY",s="FWRWW",o="FWY",a="FWRWY",c="FWY",l="FWRRRRY";(0,t.t6)("protein-distance-function",(async()=>{const e=(await be("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP")).getDistanceFunctionName();(0,t.E3)(e,we.Z.LEVENSHTEIN)})),(0,t.t6)("DNA-distance-function",(async()=>{const e=(await be("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,we.Z.LEVENSHTEIN)})),(0,t.t6)("MSA-distance-function",(async()=>{const e=(await be("seq\nATAACATAAC\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.E3)(e,we.Z.HAMMING)})),(0,t.t6)("levenstein-sub",(async()=>{const e=we.V[we.Z.LEVENSHTEIN]();ve(i,s,e,.2)})),(0,t.t6)("levenstein-del",(async()=>{const e=we.V[we.Z.LEVENSHTEIN]();ve(o,a,e,.4)})),(0,t.t6)("hamming",(async()=>{const e=we.V[we.Z.HAMMING]();ve(o,a,e,.6)})),(0,t.t6)("needleman-blosum62",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});ve(i,s,e,-6)})),(0,t.t6)("needleman-blosum62-del",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({gapOpen:8,gapExtend:2});ve(o,a,e,-3.667)})),(0,t.t6)("needleman-custom-sub",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});ve(i,s,e,.2)})),(0,t.t6)("needleman-custom-del",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});ve(o,a,e,.667)})),(0,t.t6)("needleman-custom-zero-extend",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:0});ve(c,l,e,.333)})),(0,t.t6)("needleman-custom-half-extend",(async()=>{const e=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:2,gapExtend:1});ve(c,l,e,1.667)})),(0,t.t6)("needleman-custom-same-extend",(async()=>{const t=we.V[we.Z.NEEDLEMANN_WUNSCH]({scoringMatrix:n,alphabetIndexes:r,gapOpen:1,gapExtend:1});e.Test.isInBenchmark?ve(Array(1e3).fill(c).join(""),Array(1e3).fill(l).join(""),t,1.333):ve(c,l,t,1.333)}),{benchmark:!0})}));var Ae=n(684);async function Ee(e,n,r,i,s,o,l,u){await a.data.detectSemanticTypes(e);const d=await(0,c.activityCliffs)(e,e.getCol(r),e.getCol(i),s,n,l,u,{[`${Ae.vb}`]:!0});(0,t.E3)(null!=d,!0);const h=Array.from(d.root.children).find((e=>{const t=e.className.split(" ");return["ui-btn","ui-btn-ok"].every((e=>t.includes(e)))}));(0,t.E3)(h.innerText.toLowerCase(),`${o} cliffs`)}var Ce=n(2780),Te=n(9039);async function Se(n,r,i){const s=n.getCol(i),o=await a.functions.call("Bio:detectMacromolecule",{col:s});o&&(s.semType=o);const l=e.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];if(!l)throw new Error("Preprocessing function not found");const u=await(0,c.sequenceSpaceTopMenu)(n,n.col(i),r,we.Z.LEVENSHTEIN,!0,l,{[Ae.vb]:!0});(0,t.E3)(null!=u,!0)}(0,t.L1)("activityCliffs",(async()=>{let n,r,i;const s=e.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0],o=e.Func.find({name:"helmPreprocessingFunction",package:"Bio"})[0];(0,t.gM)((async()=>{n=await(0,Q.b)(),r=await(0,L.pj)(),i=await(0,I.ub)(),await(0,I.yZ)(),await r.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(i),await r.loadMonomerLib(!0)})),(0,t.t6)("activityCliffsOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv",tgt:{cliffCount:53}}:{fileName:"tests/100_3_clustests.csv",tgt:{cliffCount:3}},n=await _(t.fileName);a.shell.addTableView(n),await Ee(n,Te.c.UMAP,"sequence","Activity",90,t.tgt.cliffCount,we.Z.LEVENSHTEIN,s)}),{benchmark:!0}),(0,t.t6)("activityCliffsWithEmptyRows",(async()=>{const e=await _("tests/100_3_clustests_empty_vals.csv");a.shell.addTableView(e),await Ee(e,Te.c.UMAP,"sequence","Activity",90,3,we.Z.LEVENSHTEIN,s)})),(0,t.t6)("Helm",(async()=>{const e=await _e.files.readCsv("samples/HELM_50.csv");a.shell.addTableView(e),await Ee(e,Te.c.UMAP,"HELM","Activity",65,20,Ce.aT.Tanimoto,o)}))})),(0,t.L1)("sequenceSpace",(async()=>{let n,r,i,s;(0,t.t6)("sequenceSpaceOpens",(async()=>{const t=e.Test.isInBenchmark?{fileName:"tests/peptides_motif-with-random_10000.csv"}:{fileName:"tests/100_3_clustests.csv"};n=await _(t.fileName),r=a.shell.addTableView(n),await Se(n,Te.c.UMAP,"sequence")}),{benchmark:!0}),(0,t.t6)("sequenceSpaceWithEmptyRows",(async()=>{i=await _("tests/100_3_clustests_empty_vals.csv"),s=a.shell.addTableView(i),await Se(i,Te.c.UMAP,"sequence")}))})),(0,t.L1)("Scoring",(()=>{const n="sequence",r="expected_similarity",i="expected_identity",s=e.DataFrame.fromCsv(`${n},${r},${i}\nPEPTIDE1{Aca.Orn.gGlu.Pqa.D-His_1Bn.dH.hHis.4Abz.D-Tic.D-Dap.Y.Iva.meS.F.P.F.D-1Nal}$$$$,1.0,1.0\nPEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC}$$$$,0.68,0.53\nPEPTIDE1{[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal].[1Nal]}$$$$V2.0,0.34,0.0`),o=s.getCol(n);o.meta.units=l.Hi.HELM,o.semType=e.SEMTYPE.MACROMOLECULE;const a=o.get(0);let u,d;(0,t.gM)((async()=>{u=await(0,c.getMonomerLibHelper)(),d=await(0,I.ub)(),await(0,I.yZ)(),await u.loadMonomerLib(!0)})),(0,t.Pl)((async()=>{await(0,I.Eu)(d),await u.loadMonomerLib(!0)})),(0,t.t6)("Identity",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,a);for(let n=0;n<e.length;n++){const r=e.get(n),o=s.get(i,n);(0,t.Wj)(r,o,.01,`Wrong identity score for sequence at position ${n}`)}})),(0,t.t6)("Identity-shortReference",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva}$$$$");(0,t.E3)(C().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Identity-longReference",(async()=>{const e=await(0,c.sequenceIdentityScoring)(s,o,"PEPTIDE1{Iva.Gly_allyl.gGlu.Pqa.D-Dip.dH.hHis.4Abz.D-aHyp.D-Dap.Y.Iva.I.Tyr_26diMe.P.Asu.meC.I.Tyr_26diMe.P.Asu.meC}$$$$");(0,t.E3)(C().count(0).take(e.length).map((t=>e.get(t))).every((e=>null!=e&&!isNaN(e))),!0)})),(0,t.t6)("Similarity",(async()=>{const e=await(0,c.sequenceSimilarityScoring)(s,o,a);for(let n=0;n<e.length;n++){const i=e.get(n),o=s.get(r,n);(0,t.Wj)(i,o,.01,`Wrong similarity score for sequence at position ${n}`)}}))}));const _e=new e.Package;async function Pe(n,r,i,s){const o=await(0,t.N$)({category:n,test:r,testContext:i,stressTest:s});return e.DataFrame.fromObjects(o)}})(),bio_test=r})();
8
8
  //# sourceMappingURL=package-test.js.map