@datagrok/bio 2.15.0 → 2.15.2

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (13) hide show
  1. package/CHANGELOG.md +11 -0
  2. package/dist/731.js +1 -1
  3. package/dist/731.js.map +1 -1
  4. package/dist/package-test.js +3 -3
  5. package/dist/package-test.js.map +1 -1
  6. package/dist/package.js +2 -2
  7. package/dist/package.js.map +1 -1
  8. package/package.json +7 -7
  9. package/src/tests/detectors-benchmark-tests.ts +16 -30
  10. package/src/tests/monomer-libraries-tests.ts +2 -4
  11. package/src/tests/pepsea-tests.ts +1 -1
  12. package/src/utils/monomer-lib/monomer-manager/monomer-manager.ts +8 -1
  13. package/src/utils/pepsea.ts +2 -1
package/dist/package.js CHANGED
@@ -1,8 +1,8 @@
1
- var bio;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>r});var i=n(7362);class r extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in r.aaSynonyms?r.aaSynonyms[e]:e;return super.get(t)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(e="grok"){switch(e){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",i="";for(const r of e)"("==r?t++:")"==r?t--:t?n+=r:i+=r;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[i,r]=this.getInnerOuter(e);if(i=i.length>6?`${i.slice(0,3)}...`:i,r=r.length>6?`${r.slice(0,3)}...`:r,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,r,1]:[this.undefinedColor,i,r,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,r,2]:[this.undefinedColor,i,r,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,r,3]:[this.undefinedColor,i,r,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,r,4]:[this.undefinedColor,i,r,4]}return[this.undefinedColor,i,r,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>r});var i=n(6082);async function r(){const e=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},9124:(e,t,n)=>{"use strict";n.d(t,{b:()=>o});var i=n(7389),r=n(6082);async function o(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}r.JsInputBase,i.input.helmAsync=async function(e,t){return(await o()).createHelmInput(e,t)}},4356:(e,t,n)=>{"use strict";n.d(t,{Es:()=>s,Eu:()=>c,so:()=>o,ub:()=>l});var i=n(4328);const r="Libraries",o="System:AppData/Bio/monomer-libraries/",s="System:AppData/Bio/monomer-sets/";let a=Promise.resolve();async function l(){let e;return a=a.then((async()=>{const t=await i.dapi.userDataStorage.getValue(r,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await a,e}async function c(e){a=a.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await i.dapi.userDataStorage.postValue(r,"Settings",JSON.stringify(e),!0)})),await a}},6718:(e,t,n)=>{"use strict";n.d(t,{A7:()=>p,pj:()=>u,uL:()=>h,uX:()=>c});var i=n(6082),r=n(4328),o=n(6295),s=n(3151),a=n(2738),l=(n(826),n(3077));function c(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(s.Ec).forEach((t=>{if("symbol"===t){const r=e.get(s.Ec[t],n);i[t]="."===r?e.get(s.yw,n):r}else if("rgroups"===t){const r=e.get(s.Ec[t],n).split("\n"),o=[];r.forEach((e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,o.push(t)})),i[t]=o}else s.Ec[t]&&(i[t]=e.get(s.Ec[t],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}async function u(){const e=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function h(e,t){e instanceof i.Column&&(e=(0,l.R)(e).columns.toList());const n=(await u()).getMonomerLib(),o=new Array(e.length),s=e[0].length,c=new Float32Array(s);for(let l=0;l<e.length;++l){const u=l<t.length?t.getCanonical(l):a._S,h=n.getMonomer("PEPTIDE",u)?.smiles??"",d=e[l],p=d.getRawData(),m=d.categories,f=m.indexOf("");if(o[l]={categories:m,data:p,emptyIndex:f},void 0===u)continue;const g=i.Column.fromStrings("smiles",m.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(i.DataFrame.fromColumns([g]),await r.chem.getSimilarities(g,h)),b=y?y.getRawData():null;for(let e=0;e<s;++e){const t=p[e];u!==a._S&&t!==f?c[e]+=b[t]:u===a._S&&t===f&&(c[e]+=1)}}for(let n=0;n<c.length;++n){let r=c[n]/t.length;for(let s=0;s<e.length;++s){const e=o[s];if(s>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&s<t.length){r=i.FLOAT_NULL;break}}c[n]=r}return i.Column.fromFloat32Array("Similarity",c)}async function d(e){const t=(await u()).getMonomerLib(),n=[],o={},s=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let t=0;t<s.length;++t){o[e[t]]=t;const i=s[t],l=""===i?new Array(s.length).fill(0):(await r.chem.getSimilarities(a,i)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:o}}async function p(e,t="Morgan"){const n=(await u()).getMonomerLib(),r=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),s={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(e);const c=i.Column.fromStrings("smiles",a),h=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await d(e);for(let t=0;t<h.length;++t)if(r[t][t]=1,s[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(r[t][e]=r[e][t]=(0,o.$1)(h[t],h[e]));return{scoringMatrix:r,alphabetIndexes:s}}},7384:(e,t,n)=>{"use strict";n.d(t,{C4:()=>d});var i=n(4328),r=n(6082),o=n(1991),s=n.n(o),a=n(439),l=n(826);const c={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(3151);function h(e){return Math.round(c.PRECISION_FACTOR*e)/c.PRECISION_FACTOR}async function d(e,t,o){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==r.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let h=t;const d=l.GO.forColumn(t);d.isHelm()&&(h=d.convert(a.Hi.SEPARATOR,"."),h.name=t.name);const m=l.GO.forColumn(h).alphabet;let f;if(m===a.YI.PT||m===a.YI.UN)f="PEPTIDE";else{if(m!==a.YI.RNA&&m!==a.YI.DNA)return{col:null,warnings:[`Unexpected column's '${h.name}' alphabet '${m}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),r=l.GO.forColumn(e);let o=!1;for(let e=0;e<t;++e){const t=r.getSplitted(e);o||(o=0===t.length),n[e]=s()(t.canonicals).filter((e=>!r.isGap(e))).map((e=>e)).toArray()}return o&&i.shell.warning(`Some values in the "${e.name}" column are empty`),n}(h),y=await async function(e,t,n,r){const o=function(e,t,n){const i=new Map;for(const r of e.getMonomerSymbolsByType(t)){const o=e.getMonomer(t,r);if("RNA"===t&&("Branch"===o.monomerType||n===a.YI.DNA&&o.symbol===c.DEOXYRIBOSE||n===a.YI.RNA&&o.symbol===c.RIBOSE||o.symbol===c.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==o.monomerType){const e={};u.f6.forEach((t=>{e[t]=o[t]})),i.set(o.symbol,e)}}return i}(t,n,r),s=new Map,l=await i.functions.call("Chem:getRdKitModule"),h={value:null};if("RNA"===n){const e=r===a.YI.RNA?[c.RIBOSE,c.PHOSPHATE]:[c.DEOXYRIBOSE,c.PHOSPHATE];for(const t of e)p(s,t,o,l,n,h)}for(let t=0;t<e.length;++t){const i=e[t];for(const e of i)if(""!==e)try{p(s,e,o,l,n,h)}catch(t){const n=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${i}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return s}(g,o,f,m),b=h.length,{molfileList:v,molfileWarningList:w}=await async function(e,t,i,r,o){const s=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(s).fill(null).map((()=>new Worker(new URL(n.p+n.u(248),n.b)))),l=o/s;let c=[],u=[];const h=new Array(s);for(let n=0;n<s;n++){const c=Math.floor(n*l),u=n===s-1?o:Math.floor((n+1)*l);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:i,polymerType:r,start:c,end:u}),h[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(h)).forEach((e=>{c=c.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:c,molfileWarningList:u}}(g,y,m,f,b);if(w.length>.05*b)throw new Error("Too many errors getting molfiles.");const C=`molfile(${h.name})`,A=e.columns.getUnusedName(C),S=r.Column.fromStrings(A,v);return S.semType=r.SEMTYPE.MOLECULE,S.meta.units=r.UNITS.Molecule.MOLBLOCK,{col:S,warnings:w}}function p(e,t,n,i,r,o){if(!e.has(t)){const s=function(e,t,n,i,r){if(t.has(e)){const s=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(s.rgroups),l=(o=s.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(e));)i.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(i[1]),parseInt(i[3]));return t}(o):function(e){const t=new Map;let n=e.indexOf(c.V2K_A_LINE,0),i=n;for(;-1!==n;){i=e.indexOf("\n",n);const r=parseInt(e.substring(n,i).replace(/^A\s+/,""));n=e.indexOf("R",i),i=e.indexOf("\n",n);const o=parseInt(e.substring(n,i).replace(/^R/,""));t.set(r,o),n=e.indexOf(c.V2K_A_LINE,i)}for(n=e.indexOf(c.V2K_RGP_LINE,0),i=e.indexOf("\n",n);-1!==n;){n+=c.V2K_RGP_SHIFT,i=e.indexOf("\n",n);const r=e.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<r.length;e+=2){if(t.has(r[e])&&t.get(r[e])!==r[e+1])throw new Error(`r-group index ${r[e]} has already been added with a different value`);t.set(r[e],r[e+1])}n=e.indexOf(c.V2K_RGP_LINE,i)}return t}(o),u=s.molfile.includes("V3000")?s.molfile:function(e,t){const n=t.get_mol(e),i=n.get_v3Kmolblock();return n.delete(),i}(function(e){let t=e.indexOf(c.V2K_A_LINE,0);-1===t&&(t=e.indexOf(c.V2K_RGP_LINE));const n=e.indexOf(c.V3K_END,t);return e.substring(0,t)+e.substring(n)}(s.molfile),n),d=function(e){let t=(e=e.replaceAll("\r","")).indexOf(c.V3K_BEGIN_COUNTS_LINE)+c.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const i=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:i,bondCount:parseInt(e.substring(t,n))}}(u),p=function(e,t){const n=new Array(t),i=new Float32Array(t),r=new Float32Array(t),o=new Array(t);let s=e.indexOf(c.V3K_BEGIN_ATOM_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;l++){s=e.indexOf(c.V3K_BEGIN_DATA_LINE,s)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",s),s=a+1,a=e.indexOf(" ",s),n[l]=e.substring(s,a);const t=new Array(2);for(let n=0;n<2;++n)s=a+1,a=e.indexOf(" ",s),t[n]=parseFloat(e.substring(s,a));i[l]=t[0],r[l]=t[1],s=a,a=e.indexOf("\n",s)+1,o[l]=e.slice(s,a),s=a}return{atomTypes:n,x:i,y:r,kwargs:o}}(u,d.atomCount),g=function(e,t){const n=new Uint32Array(t),i=new Array(t),r=new Map,o=new Map;let s=e.indexOf(c.V3K_BEGIN_BOND_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;++l){const t=new Array(3);s=e.indexOf(c.V3K_BEGIN_DATA_LINE,a)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(e.indexOf("\n",s),e.indexOf(" ",s)),t[n]=parseInt(e.slice(s,a));n[l]=t[0],i[l]=t.slice(1);const u=e.indexOf("\n",s);let h=e.slice(a,u),d=h.indexOf(c.V3K_BOND_CONFIG);if(-1!==d){d=h.indexOf("=",d)+1;let e=h.indexOf(" ",d);-1===e&&(e=h.length);const t=parseInt(h.slice(d,e));r.set(l,t);const n=c.V3K_BOND_CONFIG+t.toString();h=h.replace(n,"")}h||o.set(l,h)}return{bondTypes:n,atomPairs:i,bondConfiguration:r,kwargs:o}}(u,d.bondCount),b=function(e,t,n,i){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[i,r]of n)e.atomTypes[i-1]=t[r-1]}(e,n,i),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const i of[1,2])if(e.get(t.rNodes[n])===i){const e=t.rNodes[i-1];t.rNodes[i-1]=t.rNodes[n],t.rNodes[n]=e}}(i,r),m(t,r),r}(p,g,a,l),S=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=e.indexOf(")",n);t=t.concat(e.substring(n,i).split(" ").slice(1).map((e=>parseInt(e)))),n=i,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),x={atoms:p,bonds:g,meta:b,stereoAtoms:S};return"PEPTIDE"===i?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;A(e,-i[t],-r[t]);const o=v(i[n],r[n]);w(e.atoms,-o),i[e.meta.rNodes[1]-1]<0&&function(e){C(e,!1)}(e);const s=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const i=n[e],r=n[(e+1)%2];t.has(i)?t.get(i)?.push(r):t.set(i,new Array(1).fill(r))}return t}(e);let n=0;const i=e.atoms.atomTypes.length;let r=0;for(;0===n;){const o=t.get(e.meta.terminalNodes[1])[r];if(e.atoms.atomTypes[o-1]===c.OXYGEN&&o!==e.meta.rNodes[1]&&(n=o),r++,r>i)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${i}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){C(e,!0)}(e),w(e.atoms,-function(e,t){return v(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,s),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const i=t-1,r=n-1,o=e.atoms.x,s=e.atoms.y,a=o[i],l=s[i];o[i]=o[r],s[i]=s[r],o[r]=a,s[r]=l}(e,t,e.meta.rNodes[1])}(e,s)}(x):e===c.RIBOSE||e===c.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,i=e.atoms.y;let r=e.meta.terminalNodes[0]-1;const o=e.meta.rNodes[1]-1;A(e,-n[r],-i[r]);const s=v(n[o],i[o]);w(e.atoms,3*Math.PI/2-s),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,i=e.meta.rNodes[2]-1,r=e.meta.terminalNodes[2]-1,o=t[i]-t[r],s=n[i]-n[r];return Math.atan(s/o)+Math.PI/2}(e),r=e.meta.terminalNodes[0]-1,A(e,-n[r],-i[r])}(x,r):e===c.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;A(e,-i[t],-r[t]);const o=v(i[n],r[n]);w(e.atoms,Math.PI/2-o)}(x):function(e,t){const n=e.atoms.x,i=e.atoms.y,r=e.meta.terminalNodes[0]-1,o=e.meta.rNodes[0]-1;A(e,-n[r],-i[r]);const s=v(n[o],i[o]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");w(e.atoms,Math.PI-s+a);const l=function(e,t){return h(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:i[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:i[e.meta.terminalNodes[0]-1]});if(1!=l)for(let e=0;e<n.length;++e)n[e]=h(n[e]/l),i[e]=h(i[e]/l)}(x,r),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===c.RIBOSE||n===c.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],m(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===c.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],A(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(i,x,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===c.HYDROGEN&&(y(e,t+1),--t),++t}(x),x}var o;return null}(t,n,i,r,o);if(!s)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,s)}}function m(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const i=t.terminalNodes,r=e.atomPairs;let o=0,s=0;for(;o<r.length&&s<i.length;){for(let e=0;e<i.length;++e)for(let t=0;t<2;++t)r[o][t]===n[e]&&(i[e]=r[o][(t+1)%2],n.length,++s);++o}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[h(e.atoms.x[t]-e.atoms.x[n]),h(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,i=e.atoms,r=e.bonds,o=e.meta;i.atomTypes.splice(n,1),i.x=b(Float32Array,i.x,n,1),i.y=b(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let e=0;e<o.terminalNodes.length;++e)o.terminalNodes[e]>t?--o.terminalNodes[e]:o.terminalNodes[e]===t&&(o.terminalNodes[e]=-1);for(let e=0;e<o.rNodes.length;++e)o.rNodes[e]>t?--o.rNodes[e]:o.rNodes[e]===t&&(o.rNodes[e]=-1);let s=0;for(;s<r.atomPairs.length;){const e=r.atomPairs[s][0],n=r.atomPairs[s][1];e===t||n===t?(r.atomPairs.splice(s,1),r.bondTypes=b(Uint32Array,r.bondTypes,s,1),r.bondConfiguration.has(s)&&r.bondConfiguration.delete(s),r.kwargs.has(s)&&r.kwargs.delete(s),--s):(r.atomPairs[s][0]=e>t?e-1:e,r.atomPairs[s][1]=n>t?n-1:n),++s}let a=Array.from(r.bondConfiguration.keys());a.forEach((e=>{if(r.bondConfiguration.has(e)&&e>n){const t=r.bondConfiguration.get(e);r.bondConfiguration.delete(e),r.bondConfiguration.set(e-1,t)}})),a=Array.from(r.kwargs.keys()),a.forEach((e=>{if(r.kwargs.has(e)&&e>n){const t=r.kwargs.get(e);r.kwargs.delete(e),r.kwargs.set(e-1,t)}}))}}function b(e,t,n,i){const r=new e(t.length-i);let o=0,s=0;for(;o<t.length;)o===n&&(o+=i),r[s]=t[o],++s,++o;return r}function v(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const i=t/e,r=Math.atan(i);n=e<0?Math.PI/2+r:-Math.PI/2+r}return n}function w(e,t){if(0!==t){const n=e.x,i=e.y,r=Math.cos(t),o=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=h(t*r-i[e]*o),i[e]=h(t*o+i[e]*r)}}}function C(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const i=1===t?3:1;n.set(e,i)}}function A(e,t,n){const i=e.atoms.x,r=e.atoms.y;for(let e=0;e<i.length;++e)i[e]=h(i[e]+t),void 0!==n&&(r[e]=h(r[e]+n))}},1093:(e,t,n)=>{"use strict";n.d(t,{A:()=>r});var i=n(7362);class r extends i.e{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new r({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class o{}o.SemType="Nucleotides",o.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",o.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>i});class i{static makePalette(e,t=!1,n=i){const r={};return e.forEach((e=>{const n=e[0],i=e[1];n.forEach(((e,n)=>{r[e]=this.colourPalette[i][t?0:n]}))})),new n(r)}constructor(e){this._palette=e}get(e){return this._palette[e]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4152:(e,t,n)=>{"use strict";n.d(t,{oT:()=>c});var i=n(6082),r=n(7362);class o{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class s{}class a extends s{get(e){return"#666666"}}class l extends s{static buildPalette(){return[].concat(...Object.values(r.e.colourPalette))}get(e){const t=o.hashCode(e)%l.palette.length;return function(e){if(null==e)return"rgb(100,100,100)";const t=i.Color.fromHtml(e),n=i.Color.g(t),r=i.Color.r(t),o=i.Color.b(t),s=Math.sqrt(Math.pow(0-r,2)+Math.pow(0-n,2)+Math.pow(0-o,2));return s>210?`rgb(${r/s*210},${n/s*210},${o/s*210})`:i.Color.toRgb(t)}(l.palette[t])}}l.palette=l.buildPalette();class c extends r.e{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},6642:(e,t,n)=>{"use strict";n.d(t,{h:()=>s,s:()=>a});var i=n(4328),r=n(1858),o=n(8070);function s(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const i=e.cell.column;if(t=t??i.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,o.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},6882:(e,t,n)=>{"use strict";n.d(t,{J:()=>u});var i=n(6082),r=n(1991),o=n.n(r),s=n(826),a=n(6642),l=n(6718),c=n(9192);class u extends a.s{constructor(e,t,n,r,o){super(e,t,n),this.monomerLengthLimit=r,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=i.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,l.pj)().then((e=>{if(this.destroyed)return;const t=e.getMonomerLib();this.subs.push(t.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=i.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset()}getCellMonomerLengths(e,t){if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,c.AP)(e);this.logger.error(t,void 0,n)}const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),i=new Array(n.length+1);i[0]=5;for(let e=1;e<i.length;e++)i[e]=i[e-1]+n[e-1];return[n,i]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),i=s.GO.forColumn(this.tableCol).getSplitted(e).originals,r=Math.min(n,i.length);let o=this._monomerLengthList[e];if(null===o||o.length<r){o=this._monomerLengthList[e]=new Array(i.length);let t=0;for(let e=0;e<r;++e){const n=i[e],r=this.props.monomerToShort(n,this.monomerLengthLimit),s=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.monomerCharWidth;if(o[e]=s,t+=s,t>this.colWidth)break}}return o}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.monomerCharWidth,o=Math.ceil(this.colWidth/r);for(let e=n;e<i;e++){if(this._processedRows.get(e)&&o<=this._processedMaxVisibleSeqLength)continue;const n=s.GO.forColumn(this.tableCol).getSplitted(e,o).originals,i=Math.min(o,n.length);i>t.length&&t.push(...new Array(i-t.length).fill(r));let a=0;for(let e=0;e<i;++e){const i=n[e],r=this.props.monomerToShort(i,this.monomerLengthLimit),o=this.props.separatorWidth+r.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,o),a+=o,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,o)}return t}getPosition(e,t,n){const[i,r]=this.getCellMonomerLengths(e,n),a=s.GO.forColumn(this.tableCol);return 0===o()(a.getSplitted(e).originals).toArray().length?null:function(e,t){let n,i=100,r=0,o=e.length-1;for(;r<=o;){if(n=Math.floor((o+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?o=n-1:r=n+1,--i<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.dirty=!0}setSeparatorWidth(e){this.props.separatorWidth=e,this.dirty=!0}isMsa(){return this.props.seqHandler.isMsa()}}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>l,Ec:()=>o,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>r});const i=["symbol","molfile","rgroups","name"],r="MonomerName",o={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(e,t,n)=>{"use strict";function i(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function r(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):void 0}function o(e){return[i(e),r(e)]}n.d(t,{AP:()=>o})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>s});var i=n(6082),r=n(826),o=n(439);class s{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const i=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=i.Column.fromStrings("description",this.descriptionsArray),t=i.Column.fromStrings("sequence",this.sequencesArray);return t.semType=i.SEMTYPE.MACROMOLECULE,t.meta.units=o.Hi.FASTA,r.GO.forColumn(t),[i.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>u,dW:()=>c});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(826),l=n(9322);function c(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function u(e=s.Hi.SEPARATOR,t=s.YI.PT,n=(e===s.Hi.SEPARATOR?"-":void 0),r=void 0,c="seq",u=100,h=10**6){const d=t===s.YI.UN?r?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(t)),p=d.length,m=i.Column.fromType(i.COLUMN_TYPE.STRING,c,u);m.semType=i.SEMTYPE.MACROMOLECULE,m.meta.units=e,m.setTag(s.gp.alphabet,t),e==s.Hi.SEPARATOR&&m.setTag(s.gp.separator,n);const f=a.GO.forColumn(m);for(let t=0;t<u;t++){const n=o().count(0).take(h).map((e=>d[Math.floor(Math.random()*p)])).toArray(),i=f.joiner(new l.Mu(n,a.b9[e]));m.set(t,i)}return m}},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>r,gp:()=>o,q7:()=>u,z1:()=>a});var i,r,o,s=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(i||(i={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(r||(r={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(o||(o={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new s.aD(r.PT,c.fasta.peptide,.5),new s.aD(r.DNA,c.fasta.dna,.55),new s.aD(r.RNA,c.fasta.rna,.55)]},2003:(e,t,n)=>{"use strict";n.d(t,{Hi:()=>i.Hi,J9:()=>r.J9,Qf:()=>r.Qf,SM:()=>r.SM,YI:()=>i.YI,dh:()=>r.dh,gp:()=>i.gp,mn:()=>r.mn,ny:()=>r.ny,q7:()=>i.q7,qp:()=>r.qp,z1:()=>i.z1,zS:()=>r.zS});var i=n(439),r=n(9322)},2738:(e,t,n)=>{"use strict";n.d(t,{XN:()=>o,_S:()=>i,aD:()=>r});const i="";class r{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class o extends r{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},9322:(e,t,n)=>{"use strict";n.d(t,{Mu:()=>m,pc:()=>_,Qf:()=>E,ny:()=>I,Iv:()=>A,dh:()=>b,zS:()=>x,SM:()=>M,mn:()=>T,J9:()=>g,tm:()=>y,qp:()=>C});var i=n(6082),r=n(1991),o=n.n(r),s=n(2738),a=n(439),l=n(826);class c extends Float32Array{}var u=n(3629),h=n(8924),d=n(1093),p=n(4152);class m{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===l.b9[a.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?s._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}const g=e=>{const t=o()(e.toString().matchAll(a.B5)).map((e=>e[2]??e[1])).toArray();return new m(t,l.b9[a.Hi.FASTA])},y=e=>e?new f(e):new m([],l.b9[a.Hi.FASTA]);function b(e,t=void 0){return n=>{if(n){let i;const r=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){r.lastIndex=0,i=new Array(Math.ceil(t));let e=null,o=0;for(;null!==(e=r.exec(n))&&o<t;)i[o++]=e[0].replace('"-"',"").replace("'-'","");i.splice(o)}else i=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new m(i,l.b9[a.Hi.SEPARATOR])}return new m([],l.b9[a.Hi.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g,C=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,i=n?n.split("."):[];return new m(i.map((e=>{w.lastIndex=0;const t=w.exec(e);return t&&t.length>=2?t[1]:e})),l.b9[a.Hi.HELM])};function A(e,t,n=void 0){if(e.toLowerCase().startsWith(a.Hi.FASTA))return g;if(e.toLowerCase().startsWith(a.Hi.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.Hi.HELM))return C;throw new Error(`Unexpected units ${e} .`)}const S=/([^\W_]+)/g;function x(e,t){if(e.length<=t)return e;const n=e.match(S),i=e.length>t||(n?.length??0)>1,r=n?.[0]??" ";return i?r.substring(0,t-1)+"…":r}function E(e){switch(e){case a.YI.DNA:return a.Vl.fasta.dna;case a.YI.RNA:return a.Vl.fasta.rna;case a.YI.PT:return a.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function _(e,t,n="-"){const i=t.map((t=>{const i=function(e,t,n="-"){const i=new Set([...new Set(Object.keys(e)),...t]);i.delete(n);const r=[],o=[];for(const n of i)r.push(n in e?e[n]:0),o.push(t.has(n)?1:0);const s=new c(r),a=new c(o);return(0,u.KE)(s,a)/((0,u.wQ)(s)*(0,u.wQ)(a))}(e,t.alphabet,n);return new s.XN(t,e,i)}));let r;const o=Math.max(...i.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return r=o>0?i.find((e=>e.similarity===o)).name:a.YI.UN,r}function M(e,t=5){let n;if(e.semType==i.SEMTYPE.MACROMOLECULE)n=l.GO.forColumn(e).alphabet;else{const i=function(e,t,n){const i=e.categories;return function(e,t){const n={};let i=!0,r=null;for(const o of e)if(null==r?r=o.length:o.length!==r&&(i=!1),o.length>=t)for(const e of o.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:i}}(o().enumerate(e.getRawData()).map((([e,t])=>n(i[e]))),t)}(e,t,g);n=_(i.freq,a.q7)}return I(n)}function I(e){switch(e){case a.YI.PT:return h.X.GrokGroups;case a.YI.DNA:case a.YI.RNA:return d.A.Chromatogram;default:return p.oT.Color}}function T(e){const t=e.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},826:(e,t,n)=>{"use strict";n.d(t,{GO:()=>m,b9:()=>p,j8:()=>d});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(2738),l=n(9322),c=n(6863),u=n(6718),h=n(3151);const d=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},p={[s.Hi.FASTA]:"-",[s.Hi.SEPARATOR]:"",[s.Hi.HELM]:"*"};class m{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==i.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${i.TYPE.STRING}'.`);this._column=e;const t=this._column.meta.units;if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?p[s.Hi.FASTA]:this.isHelm()?p[s.Hi.HELM]:p[s.Hi.SEPARATOR],!this.column.tags.has(s.gp.aligned)||!this.column.tags.has(s.gp.alphabet)||!this.column.tags.has(s.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===s.YI.UN)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(s.gp.separator);m.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.meta.units}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(s.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(s.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${s.gp.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[d.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE||e.column.meta.units!==s.Hi.FASTA)throw new Error(`The column of notation '${s.Hi.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=s.Hi.FASTA,m.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE||e.column.meta.units!==s.Hi.SEPARATOR)throw new Error(`The column of notation '${s.Hi.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${s.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=s.Hi.SEPARATOR,e.column.setTag(s.gp.separator,t),m.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${s.Hi.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=s.Hi.HELM,m.setTags(e)}static setTags(e){const t=e.column.meta.units;if([s.Hi.FASTA,s.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(s.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(s.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(s.gp.aligned,t));let n=e.column.getTag(s.gp.alphabet);if(null===n&&(n=(0,l.pc)(e.stats.freq,s.q7),e.column.setTag(s.gp.alphabet,n)),n===s.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(s.gp.alphabetSize,t.toString()),e.column.setTag(s.gp.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(s.gp.separator)??void 0;if(this.notation===s.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(s.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(s.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(s.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==s.Hi.HELM||this.alphabet==s.YI.UN){const e=this.column.getTag(s.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case s.YI.PT:return 20;case s.YI.DNA:case s.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===s.Hi.HELM||this.alphabet===s.YI.UN&&"true"===this.column.getTag(s.gp.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}async getHelm(e,t){const n=this.column.get(e);return this.notationProvider?(await this.notationProvider.getHelm(this.column,t)).get(e):this.convertToHelm(n)}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(t=!1);for(const t of i.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...o().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(s.gp.positionNames);this._posList=e?e.split(s.z1).map((e=>e.trim())):o().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===s.Hi.FASTA}isSeparator(){return this.notation===s.Hi.SEPARATOR}isHelm(){return this.notation===s.Hi.HELM}isRna(){return this.alphabet===s.YI.RNA}isDna(){return this.alphabet===s.YI.DNA}isPeptide(){return this.alphabet===s.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(s.Hi.FASTA))return s.Hi.FASTA;if(this.units.toLowerCase().startsWith(s.Hi.SEPARATOR))return s.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(s.Hi.HELM))return s.Hi.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,r){const o=this.column,a=e.toLowerCase()+"("+o.name+")",l=n??o.dataFrame.columns.getUnusedName(a),c=i.Column.fromList("string",l,r??new Array(this.column.length).fill(""));if(c.semType=i.SEMTYPE.MACROMOLECULE,c.meta.units=e,e===s.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${s.Hi.SEPARATOR}' requires separator value.`);c.setTag(s.gp.separator,t)}c.setTag(i.TAGS.CELL_RENDERER,e===s.Hi.HELM?"helm":"sequence");const u=o.getTag(s.gp.aligned);u&&c.setTag(s.gp.aligned,u);let h=o.getTag(s.gp.alphabet);h||this.notation!==s.Hi.HELM||e===s.Hi.HELM||(h=s.YI.UN),null!=h&&c.setTag(s.gp.alphabet,h);let d=o.getTag(s.gp.alphabetSize);null!=h&&d&&c.setTag(s.gp.alphabetSize,d);const p=o.getTag(s.gp.alphabetIsMultichar);return null!=h&&void 0!==p&&c.setTag(s.gp.alphabetIsMultichar,p),e==s.Hi.HELM&&(d=this.getAlphabetSize().toString(),c.setTag(s.gp.alphabetSize,d)),c}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=m.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[s.Hi.FASTA,s.Hi.SEPARATOR,s.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!m.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const r=i.Column.fromList("string",t,new Array(e).fill(""));return r.semType=i.SEMTYPE.MACROMOLECULE,r.meta.units=n,r}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(s.Hi.FASTA))return null===this.column.getTag(s.gp.alphabet)||this.getAlphabetIsMultichar()?s.J9:l.tm;if(this.units.toLowerCase().startsWith(s.Hi.SEPARATOR))return(0,s.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(s.Hi.HELM))return s.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return c.Z.HAMMING;switch(this.alphabet){case s.YI.DNA:case s.YI.RNA:case s.YI.PT:}return c.Z.LEVENSHTEIN}getDistanceFunction(){return c.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(s.gp.isHelmCompatible))return"true"===this.column.getTag(s.gp.isHelmCompatible);const e=(await(0,u.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,s.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let e=0;e<i;++e){const i=r[e];if(!(i in n)){n.add(i);const r=this.getSplitted(e);for(const e of r.canonicals)if(!t.has(e))return this.column.setTag(s.gp.isHelmCompatible,"false"),!1}}return this.column.setTag(s.gp.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===s.Hi.FASTA}toSeparator(e){return e===s.Hi.SEPARATOR}toHelm(e){return e===s.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?p[s.Hi.FASTA]:p[s.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),o=this.splitter(e),a=[];for(let e=0;e<o.length;++e){let n=o.getOriginal(e);if(r&&(n=n.replace(h.EK,"")),n===p[s.Hi.HELM])a.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=e??0,o=t??this.maxLength-1,a=this.getJoiner(),c=o-r+1,u=p[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(c);for(let e=0;e<c;++e){const i=r+e;n[e]=i<t.length?t.getOriginal(i):u}return a(new l.Mu(n,u))}));const h=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(c);for(let e=0;e<c;++e){const i=r+e;n[e]=i<t.length?t[i]:"?"}return n.join(s.z1)},d=this.column.getTag(s.gp.positionNames);d&&i.setTag(s.gp.positionNames,h(d));const m=this.column.getTag(s.gp.positionLabels);return m&&i.setTag(s.gp.positionLabels,h(m)),i}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const r=this;switch(t){case s.Hi.FASTA:i=function(e){return r.joinToFasta(e,r.isHelm())};break;case s.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return f(e,n,r.isHelm())};break;case s.Hi.HELM:{const e=r.alphabet===s.YI.DNA||r.alphabet===s.YI.RNA,t=r.getHelmWrappers();i=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===s.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${s.Hi.SEPARATOR}'.`);const n=this;if(e===s.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===s.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===s.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[d.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[d.seqHandler]=new m(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const r=e.getOriginal(i);let o=e.getOriginal(i);t&&(o=o.replace(h.EK,"$1")),r===a._S?o=p[s.Hi.FASTA]:r===h.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==s.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let o=t.getOriginal(e);(i||r)&&(o=o.replace(h.EK,"$1"),o=o===h.q7?null:o),n[e]=o||null}return new l.Mu(n.filter((e=>!!e)),p[s.Hi.HELM])}}function f(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let o=e.getOriginal(t);n&&(o=o.replace(h.EK,"$1")),r===a._S?o=p[s.Hi.SEPARATOR]:r===h.q7&&(o=""),i[t]=o}return i.join(t)}function g(e,t,n){const[i,r,o,l]=t,c=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let l=e.getOriginal(t);i===a._S?l=p[s.Hi.HELM]:(n&&(l=l.replace(h.EK,"$1")),l=1===l.length?`${r}${l}${o}`:`${r}[${l}]${o}`),c[t]=l}return`${i}${c.join(".")}${l}`}},8312:(e,t,n)=>{"use strict";n.d(t,{P:()=>r,Q:()=>o});var i=n(6082);const r="substruct-col";async function o(){const e=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>o});var i=n(6082),r=n(826);function o(e){const t=e=>{const t=s.columns.addNewString((e+1).toString());return n.push(t),t},n=[],o=e.length,s=i.DataFrame.create(o),a=r.GO.forColumn(e);for(let e=0;e<o;++e){const i=a.getSplitted(e);for(let r=0;r<i.length;++r){const o=i.getOriginal(r);((n[r]??null)||t(r)).set(e,o,!1)}}return s}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>o});var i,r=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(i||(i={}));class o{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[i,o]=(0,r.AP)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,o),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},4326:(e,t,n)=>{"use strict";n.d(t,{Fo:()=>u,Lp:()=>o,P4:()=>s,fH:()=>r,gp:()=>i,lT:()=>l,mH:()=>a});var i,r,o,s,a,l,c=n(6082);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(e){e.Entropy="Entropy",e.full="100%"}(r||(r={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(o||(o={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(s||(s={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(l||(l={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=16,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},5540:(e,t,n)=>{"use strict";e=n.hmd(e);var i,r=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,r=void 0!==e?e:{};r.ready=new Promise((function(e,i){t=e,n=i}));var o,s=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(o=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),r.print||console.log.bind(console);var u,h,d=r.printErr||console.warn.bind(console);Object.assign(r,s),s=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(u=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&x("no native wasm support detected");var p,m,f,g=!1;function y(){var e=h.buffer;r.HEAP8=p=new Int8Array(e),r.HEAP16=new Int16Array(e),r.HEAP32=new Int32Array(e),r.HEAPU8=m=new Uint8Array(e),r.HEAPU16=new Uint16Array(e),r.HEAPU32=f=new Uint32Array(e),r.HEAPF32=new Float32Array(e),r.HEAPF64=new Float64Array(e)}var b=[],v=[],w=[],C=0,A=null,S=null;function x(e){r.onAbort&&r.onAbort(e),d(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var E,_;function M(e){return e.startsWith("data:application/octet-stream;base64,")}function I(e){try{if(e==E&&u)return new Uint8Array(u);if(o)return o(e);throw"both async and sync fetching of the wasm failed"}catch(e){x(e)}}function T(e,t,n){return function(e){return u||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return I(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return I(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){d("failed to asynchronously prepare wasm: "+e),x(e)}))}function L(e){for(;e.length>0;)e.shift()(r)}function N(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,p[this.ptr+12|0]=e},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(e){e=e?1:0,p[this.ptr+13|0]=e},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(H(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function $(e){var t=h.buffer;try{return h.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function P(e){return r["_"+e]}M(E="wasmDbscan.wasm")||(_=E,E=r.locateFile?r.locateFile(_,c):c+_);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(e,t,n,i,r){var o={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var i=e.charCodeAt(n);i<=127?t++:i<=2047?t+=2:i>=55296&&i<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=B(t);return function(e,t,n){!function(e,t,n,i){if(!(i>0))return 0;for(var r=n+i-1,o=0;o<e.length;++o){var s=e.charCodeAt(o);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&e.charCodeAt(++o)),s<=127){if(n>=r)break;t[n++]=s}else if(s<=2047){if(n+1>=r)break;t[n++]=192|s>>6,t[n++]=128|63&s}else if(s<=65535){if(n+2>=r)break;t[n++]=224|s>>12,t[n++]=128|s>>6&63,t[n++]=128|63&s}else{if(n+3>=r)break;t[n++]=240|s>>18,t[n++]=128|s>>12&63,t[n++]=128|s>>6&63,t[n++]=128|63&s}}t[n]=0}(e,m,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,i=B(e.length);return t=e,n=i,p.set(t,n),i}},s=P(e),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var u=o[n[c]];u?(0===l&&(l=F()),a[c]=u(i[c])):a[c]=i[c]}var h=s.apply(null,a);return function(e){return 0!==l&&D(l),function(e){return"string"===t?(n=e)?function(e,t,n){for(var i=t+n,r=t;e[r]&&!(r>=i);)++r;if(r-t>16&&e.buffer&&R)return R.decode(e.subarray(t,r));for(var o="";t<r;){var s=e[t++];if(128&s){var a=63&e[t++];if(192!=(224&s)){var l=63&e[t++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&e[t++])<65536)o+=String.fromCharCode(s);else{var c=s-65536;o+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else o+=String.fromCharCode((31&s)<<6|a)}else o+=String.fromCharCode(s)}return o}(m,n,i):"":"boolean"===t?Boolean(e):e;var n,i}(e)}(h)}var k,G={__cxa_throw:function(e,t,n){throw new N(e).init(t,n),e},abort:function(){x("")},emscripten_memcpy_big:function(e,t,n){m.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=m.length,i=2147483648;if((e>>>=0)>i)return!1;for(var r=1;r<=4;r*=2){var o=n*(1+.2/r);if(o=Math.min(o,e+100663296),$(Math.min(i,(t=Math.max(e,o))+(65536-t%65536)%65536)))return!0}return!1}},F=(function(){var e,t,i,o,s={env:G,wasi_snapshot_preview1:G};function a(e,t){var n,i=e.exports;return r.asm=i,h=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,v.unshift(n),function(){if(C--,r.monitorRunDependencies&&r.monitorRunDependencies(C),0==C&&(null!==A&&(clearInterval(A),A=null),S)){var e=S;S=null,e()}}(),i}if(C++,r.monitorRunDependencies&&r.monitorRunDependencies(C),r.instantiateWasm)try{return r.instantiateWasm(s,a)}catch(e){d("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=E,i=s,o=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||M(t)||"function"!=typeof fetch?T(t,i,o):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,i).then(o,(function(e){return d("wasm streaming compile failed: "+e),d("falling back to ArrayBuffer instantiation"),T(t,i,o)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(F=r.asm.stackSave).apply(null,arguments)}),D=function(){return(D=r.asm.stackRestore).apply(null,arguments)},B=function(){return(B=r.asm.stackAlloc).apply(null,arguments)},H=function(){return(H=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function e(){k||(k=!0,r.calledRun=!0,g||(L(v),t(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)e=r.postRun.shift(),w.unshift(e);var e;L(w)}()))}C>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)e=r.preRun.shift(),b.unshift(e);var e;L(b)}(),C>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),e()}),1)):e()))}if(r.ccall=O,r.cwrap=function(e,t,n,i){var r=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&r&&!i?P(e):function(){return O(e,t,n,arguments)}},S=function e(){k||V(),k||(S=e)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return V(),e.ready});"object"==typeof exports?e.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6295:(e,t,n)=>{"use strict";n.d(t,{$1:()=>a,Hr:()=>S,Ii:()=>m,T6:()=>A,TK:()=>w,a4:()=>d,be:()=>p,gt:()=>y,iS:()=>s,ij:()=>b,lO:()=>h,lP:()=>g,rR:()=>f,tO:()=>l,v_:()=>c,yK:()=>v,zn:()=>u});var i=n(8774),r=n(8498),o=n(6863);r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean,r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean;const s=[r.aT.Tanimoto,r.aT.Dice,r.aT.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const i=e.andWithCountBits(t,!0);return i/(n-i)}function l(e,t){return 1-a(e,t)}function c(e,t){return C(a(new i.A(e,32*e.length),new i.A(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function h(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function d(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function p(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function m(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),i=e.andWithCountBits(t,!0);return i/(2*n-3*i)}(e,t)}function f(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:e.andWithCountBits(t,!0)*n/(2*i)}(e,t))}function g(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:(e.andWithCountBits(t,!0)*n-i)/i}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function b(e,t){return C(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function v(e,t){return C(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function w(e,t){return C(function(e,t){const n=e.andWithCountBits(t,!0),i=e.countBits(!0)+t.countBits(!0),r=e.length,o=r-i+n;return n==r||o==r?1:n/i+o/(2*r-i)}(e,t))}function C(e){return 0===e?3402823e32:1/e-1}function A(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function S(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const i=e.length,r=n.length;let o=0,s=0,a=0;for(;s<i&&a<r;)e[s]===n[a]?(t?.has(e[s])||++o,++s,++a):e[s]<n[a]?++s:++a;return o}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}r.aT.Tanimoto,r.aT.Asymmetric,r.aT.Cosine,r.aT.Sokal,o.Z.HAMMING,o.Z.LEVENSHTEIN,o.Z.MONOMER_CHEMICAL_DISTANCE,o.Z.NEEDLEMANN_WUNSCH},684:(e,t,n)=>{"use strict";n.d(t,{C0:()=>o,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>r,vb:()=>l});const i="dim-red-preprocessing-function",r="supportedSemTypes",o="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(e,t,n)=>{"use strict";function i(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,i=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,r=new Float32Array((n.length+i)*(n.length+i));return Object.entries(t).forEach((([e,i])=>{const o=n[i];Object.entries(t).forEach((([t,i])=>{r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=o[i]}))})),(e,t)=>1-r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,i)=>{let r=0;const o=e.length,s=i.length,a=Math.ceil(Math.max(o,s)*(1-n));o!==s&&(r=Math.abs(o-s));let l=0;for(let n=0;n<Math.min(o,s);n++)if(e[n]!==i[n]&&(l+=t(e[n],i[n]),l>a))return 1;return l+=r,l/=Math.max(o,s),l}}n.d(t,{Z:()=>s,V:()=>a});var r=n(2787);const o={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,r.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:r,alphabetIndexes:s}={...o,...e};Object.entries(s).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,o)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let h=1;h<o.length+1;h++){a[u][0]=-i-(h-1)*i;for(let d=1;d<e.length+1;d++){const p=a[c][d-1]+r[t[e.charCodeAt(d-1)]][t[o.charCodeAt(h-1)]],m=a[c][d]-(s[d]||1===h||h===o.length?i:n),f=a[u][d-1]-(l[d-1]||1===d||d===e.length?i:n);a[u][d]=Math.max(p,f,m),a[u][d]===p?(s[d]=!1,l[d]=!1):a[u][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.min(e.length,o.length);return(h-a[c][e.length])/h}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},9039:(e,t,n)=>{"use strict";var i;n.d(t,{c:()=>i}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(i||(i={}))},8498:(e,t,n)=>{"use strict";var i,r,o,s,a,l,c;n.d(t,{EG:()=>a,Pn:()=>r,RR:()=>l,Wn:()=>c,aT:()=>o,m6:()=>s,xL:()=>i}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(i||(i={})),function(e){e.Euclidean="Euclidean"}(r||(r={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(o||(o={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(l||(l={})),function(e){e.CommonItems="Common Items"}(c||(c={}))},2780:(e,t,n)=>{"use strict";n.d(t,{xL:()=>i.xL});var i=n(8498);n(9336)},9336:(e,t,n)=>{"use strict";var i=n(2787),r=n(944),o=n(6295),s=n(3629),a=n(6863),l=n(8498);const c={[l.Pn.Euclidean]:s.ou},u={[l.xL.Levenshtein]:i.I,[l.xL.JaroWinkler]:r.Vb,[l.xL.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let i=1;i<e.length;i++)n+=e[i]==t[i]?0:1;return n/e.length}},[l.xL.Onehot]:function(e,t){return e===t?0:1}},h={[l.aT.Tanimoto]:o.tO,[l.aT.Dice]:o.zn,[l.aT.Asymmetric]:o.gt,[l.aT.BraunBlanquet]:o.ij,[l.aT.Cosine]:o.lO,[l.aT.Kulczynski]:o.rR,[l.aT.McConnaughey]:o.lP,[l.aT.RogotGoldberg]:o.TK,[l.aT.Russel]:o.yK,[l.aT.Sokal]:o.Ii,[l.aT.Hamming]:o.be,[l.aT.Euclidean]:o.a4},d={[l.m6.TanimotoIntArray]:o.v_},p={[l.RR.Difference]:o.T6},m={[l.Wn.CommonItems]:o.Hr},f={[l.EG.Vector]:{[l.Pn.Euclidean]:c[l.Pn.Euclidean]},[l.EG.String]:{[l.xL.Levenshtein]:u[l.xL.Levenshtein],[l.xL.JaroWinkler]:u[l.xL.JaroWinkler],[l.xL.Manhattan]:u[l.xL.Manhattan],[l.xL.Onehot]:u[l.xL.Onehot]},[l.EG.BitArray]:{[l.aT.Tanimoto]:h[l.aT.Tanimoto],[l.aT.Dice]:h[l.aT.Dice],[l.aT.Asymmetric]:h[l.aT.Asymmetric],[l.aT.BraunBlanquet]:h[l.aT.BraunBlanquet],[l.aT.Cosine]:h[l.aT.Cosine],[l.aT.Kulczynski]:h[l.aT.Kulczynski],[l.aT.McConnaughey]:h[l.aT.McConnaughey],[l.aT.RogotGoldberg]:h[l.aT.RogotGoldberg],[l.aT.Russel]:h[l.aT.Russel],[l.aT.Sokal]:h[l.aT.Sokal]},[l.EG.MacroMolecule]:{[a.Z.HAMMING]:a.V[a.Z.HAMMING],[a.Z.LEVENSHTEIN]:a.V[a.Z.LEVENSHTEIN],[a.Z.NEEDLEMANN_WUNSCH]:a.V[a.Z.NEEDLEMANN_WUNSCH],[a.Z.MONOMER_CHEMICAL_DISTANCE]:a.V[a.Z.MONOMER_CHEMICAL_DISTANCE]},[l.EG.Number]:{[l.RR.Difference]:p[l.RR.Difference]},[l.EG.IntArray]:{[l.m6.TanimotoIntArray]:d[l.m6.TanimotoIntArray]},[l.EG.NumberArray]:{[l.Wn.CommonItems]:m[l.Wn.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},8774:(e,t,n)=>{"use strict";n.d(t,{A:()=>i});class i{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,r=i._createBuffer(n);if(t)for(let e=0;e<r.length;e++)r[e]=-1;this._data=r,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,i){if(e<t||e>n)throw new Error(`Argument ${i} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let i=0;i<n;i++)t[i]=e[i]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new i(e._length);n._length=e._length,n._data=i._createBuffer(n._length),n._version=0;const r=e.lengthInInts;for(let i=0;i<r;i++)n._data[i]=e._data[i]&t._data[i];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new i(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new i(e);for(let i=0;i<e;++i)n.setBit(i,t(i));return n._version=0,n}static fromString(e){return i.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new i(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new i(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let r=0,o=0;for(;t-o>=4;)n._data[r++]=255&e[o]|(255&e[o+1])<<8|(255&e[o+2])<<16|(255&e[o+3])<<24,o+=4;return t-o==3&&(n._data[r]=(255&e[o+2])<<16),t-o==2&&(n._data[r]|=(255&e[o+1])<<8),t-o==1&&(n._data[r]|=255&e[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new i(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,i=this.lengthInInts;for(let e=0;e<i;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,i=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(i)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,i=!0,r=!0){if(n&&r&&this.setAll(!t,!1),r)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(i)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return n}setRange(e,t,n,i=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const r=Math.min(e,t),o=Math.max(e,t);if(n)for(let e=r;e<=o;e++)this.setTrue(e);else for(let e=r;e<=o;e++)this.setFalse(e);return this.incrementVersion(i),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const i=this._length;this.setLength(this._length+t);for(let n=i-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let i=e;i<e+t;i++)this.setBit(i,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let i=-1;-1!=(i=e.findNext(i,!t));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(e){return!!(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=i._onBitCount[255&e];let n=this._data[t];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let o=0;for(;o<r-1;o++)for(let t=this._data[o]&e._data[o];0!=t;t>>>=8)n+=i._onBitCount[255&t];let s=this._data[o]&e._data[o];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const r=this.lengthInInts;for(let o=Math.floor(e/32);o<r;o++){let r=t?this._data[o]:~this._data[o];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==r)continue;for(let t=0;0!=r;t+=8,r>>>=8){const n=i._firstOnBit[255&r];if(n>=0)return(e=n+32*o+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let r=Math.floor(e/32);r>=0;r--){let e=t?this._data[r]:~this._data[r];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=i._lastOnBit[e>>>24];if(n>=0)return n+32*r+t}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(e,t,n)=>{"use strict";n.d(t,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,o=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function s(e,t,n,i=0,r="timeout"){return o(this,void 0,void 0,(function*(){return new Promise(((o,s)=>{const a=e.subscribe((e=>{try{t(e),o("OK")}catch(e){s(e)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(r)}),i);n()}))}))}function a(e){return o(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(r||(r={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3629:(e,t,n)=>{"use strict";function i(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function r(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function o(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}function s(e,t){let n=0;const i=e.length;if(i!==t.length)throw new Error("The dimensionality of the vectors must match");for(let r=0;r<i;++r)n+=Math.pow(e[r]-t[r],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,i=0;for(let r=0;r<t;++r)n+=e[r],i+=Math.pow(e[r],2);const r=n/t,o=1/Math.sqrt(i/t-Math.pow(r,2));for(let n=0;n<t;++n)e[n]=(e[n]-r)*o;return e}n.d(t,{KE:()=>o,S8:()=>a,ou:()=>s,vA:()=>i,wQ:()=>r})},1913:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3282),r=n(9029),o=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",u=new i.Name("emUsed"),h={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:c,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=t;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(e,t){return r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath === ${w}`,i._`${e}.keyword in ${t}`,i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(e,t){const i=[];for(const n in e){const e=t[n];d.test(e)&&i.push([n,x(e)])}return n.object(...i)}function S(e){return d.test(e)?new o._Code(o.safeStringify(e).replace(p,((e,t)=>`" + JSON.stringify(${s.getData(t,b)}) + "`)).replace(m,"")):i.stringify(e)}function x(e){return i._`function(){return ${S(e)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[o,s]=function(e){let t,n;for(const i in e){if("properties"===i||"items"===i)continue;const r=e[i];if("object"==typeof r){t||(t={});const e=t[i]={};for(const t in r)e[t]=[]}else n||(n={}),n[i]=[]}return[t,n]}(v);s&&function(r){const o=n.const("emErrors",i.stringify(r)),s=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(e=>n.if(C(e,o),(()=>n.code(i._`${o}[${e}.keyword].push(${e})`).assign(i._`${e}.${u}`,!0)))));const{singleError:c}=e;if(c){const e=n.let("message",i._`""`),r=n.let("paramsErrors",i._`[]`);h((t=>{n.if(e,(()=>n.code(i._`${e} += ${"string"==typeof c?c:";"}`))),n.code(i._`${e} += ${d(t)}`),n.assign(r,i._`${r}.concat(${o}[${t}])`)})),a.reportError(t,{message:e,params:i._`{errors: ${r}}`})}else h((e=>a.reportError(t,{message:d(e),params:i._`{errors: ${o}[${e}]}`})));function h(e){n.forIn("key",o,(t=>n.if(i._`${o}[${t}].length`,(()=>e(t)))))}function d(e){return i._`${e} in ${s} ? ${s}[${e}]() : ${y}[${e}]`}}(s),o&&function(e){const r=n.const("emErrors",i.stringify(e)),o=[];for(const t in e)o.push([t,A(e[t],g[t])]);const s=n.const("templates",n.object(...o)),c=n.scopeValue("obj",{ref:h,code:i.stringify(h)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(e=>n.if(C(e,r),(()=>{n.assign(d,i._`${c}[${e}.keyword]`),n.assign(p,i._`${r}[${e}.keyword][${e}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${e})`).assign(i._`${e}.${u}`,!0)))})))),n.forIn("key",r,(e=>n.forIn("keyProp",i._`${r}[${e}]`,(o=>{n.assign(p,i._`${r}[${e}][${o}]`),n.if(i._`${p}.length`,(()=>{const r=n.const("tmpl",i._`${s}[${e}] && ${s}[${e}][${o}]`);a.reportError(t,{message:i._`${r} ? ${r}() : ${y}[${e}][${o}]`,params:i._`{errors: ${p}}`})}))}))))}(o),function(e){const{props:o,items:s}=e;if(!o&&!s)return;const h=i._`typeof ${f} == "object"`,d=i._`Array.isArray(${f})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(e,t){n.assign(p,i.stringify(e)),n.assign(v,A(e,t))}o&&s?(m=n.let("emChildKwd"),n.if(h),n.if(d,(()=>{C(s,g.items),n.assign(m,i.str`items`)}),(()=>{C(o,g.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,g.items),b=i._`.items`):o&&(n.if(r.and(h,r.not(d))),C(o,g.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(e=>function(e,t,o){n.if(r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${r}.exec(${e}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${t}`,(()=>o(a)))}))}(e,p,(t=>n.code(i._`${p}[${t}].push(${e})`).assign(i._`${e}.${u}`,!0))))),n.forIn("key",p,(e=>n.if(i._`${p}[${e}].length`,(()=>{a.reportError(t,{message:i._`${e} in ${v} ? ${v}[${e}]() : ${y}${b}[${e}]`,params:i._`{errors: ${p}[${e}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(v))}const o="string"==typeof v?v:v._;o&&function(e){const o=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(function(e){return r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,r.or(i._`${e}.instancePath === ${w}`,r.and(i._`${e}.instancePath.indexOf(${w}) === 0`,i._`${e}.instancePath[${w}.length] === "/"`)),i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${e}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(i._`${o}.push(${e})`).assign(i._`${e}.${u}`,!0))))),n.if(i._`${o}.length`,(()=>a.reportError(t,{message:S(e),params:i._`{errors: ${o}}`})))}(o),e.keepErrors||function(){const e=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(i._`!${t}.${u}`,(()=>n.code(i._`${e}.push(${t})`))))),n.assign(l.default.vErrors,e).assign(l.default.errors,i._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},7433:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv2020=void 0;const i=n(4042),r=n(6105),o=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(s.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}t.Ajv2020=l,e.exports=t=l,e.exports.Ajv2020=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var c=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var u=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var h=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var d=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv=void 0;const i=n(4042),r=n(6144),o=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(e,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}t.Ajv=c,e.exports=t=c,e.exports.Ajv=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var u=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var h=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var d=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=i;class r extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof i&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function o(e,...t){const n=[e[0]];let i=0;for(;i<t.length;)l(n,t[i]),n.push(e[++i]);return new r(n)}t._Code=r,t.nil=new r(""),t._=o;const s=new r("+");function a(e,...t){const n=[u(e[0])];let i=0;for(;i<t.length;)n.push(s),l(n,t[i]),n.push(s,u(e[++i]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===s){const n=c(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new r(n)}function l(e,t){var n;t instanceof r?e.push(...t._items):t instanceof i?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function c(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof i||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof i?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=l,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new r(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new r(`.${e}`):o`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new r(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new r(e.toString())}},9029:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const i=n(1520),r=n(7845);var o=n(1520);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return o.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return o.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return o.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return o.Name}});var s=n(7845);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),t.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class l extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?r.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof i.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class u extends c{constructor(e,t,n,i){super(e,n,i),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class p extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class m extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let i=n.length;for(;i--;){const r=n[i];r.optimizeNames(e,t)||($(e,r.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>T(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new b(e):e}return t?!1===e?t instanceof v?t:t.nodes:this.nodes.length?this:new v(P(e),t instanceof v?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return L(e,this.condition),this.else&&T(e,this.else.names),e}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return T(super.names,this.iteration.names)}}class A extends w{constructor(e,t,n,i){super(),this.varKind=e,this.name=t,this.from=n,this.to=i}render(e){const t=e.es5?r.varKinds.var:this.varKind,{name:n,from:i,to:o}=this;return`for(${t} ${n}=${i}; ${n}<${o}; ${n}++)`+super.render(e)}get names(){const e=L(super.names,this.from);return L(e,this.to)}}class S extends w{constructor(e,t,n,i){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=i}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return T(super.names,this.iterable.names)}}class x extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}x.kind="func";class E extends f{render(e){return"return "+super.render(e)}}E.kind="return";class _ extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,i;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(i=this.finally)||void 0===i||i.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&T(e,this.catch.names),this.finally&&T(e,this.finally.names),e}}class M extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}M.kind="catch";class I extends g{render(e){return"finally"+super.render(e)}}function T(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function L(e,t){return t instanceof i._CodeOrName?T(e,t.names):e}function N(e,t,n){return e instanceof i.Name?o(e):(r=e)instanceof i._Code&&r._items.some((e=>e instanceof i.Name&&1===t[e.str]&&void 0!==n[e.str]))?new i._Code(e._items.reduce(((e,t)=>(t instanceof i.Name&&(t=o(t)),t instanceof i._Code?e.push(...t._items):e.push(t),e)),[])):e;var r;function o(e){const i=n[e.str];return void 0===i||1!==t[e.str]?e:(delete t[e.str],i)}}function $(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function P(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:i._`!${G(e)}`}I.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new r.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,i){const r=this._scope.toName(t);return void 0!==n&&i&&(this._constants[r.str]=n),this._leafNode(new l(e,r,n)),r}const(e,t,n){return this._def(r.varKinds.const,e,t,n)}let(e,t,n){return this._def(r.varKinds.let,e,t,n)}var(e,t,n){return this._def(r.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new c(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==i.nil&&this._leafNode(new m(e)),this}object(...e){const t=["{"];for(const[n,r]of e)t.length>1&&t.push(","),t.push(n),(n!==r||this.opts.es5)&&(t.push(":"),(0,i.addCodeArg)(t,r));return t.push("}"),new i._Code(t)}if(e,t,n){if(this._blockNode(new v(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new v(e))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new C(e),t)}forRange(e,t,n,i,o=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const s=this._scope.toName(e);return this._for(new A(o,s,t,n),(()=>i(s)))}forOf(e,t,n,o=r.varKinds.const){const s=this._scope.toName(e);if(this.opts.es5){const e=t instanceof i.Name?t:this.var("_arr",t);return this.forRange("_i",0,i._`${e}.length`,(t=>{this.var(s,i._`${e}[${t}]`),n(s)}))}return this._for(new S("of",o,s,t),(()=>n(s)))}forIn(e,t,n,o=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,i._`Object.keys(${t})`,n);const s=this._scope.toName(e);return this._for(new S("in",o,s,t),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(e){return this._leafNode(new h(e))}break(e){return this._leafNode(new d(e))}return(e){const t=new E;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new _;if(this._blockNode(i),this.code(e),t){const e=this.name("e");this._currNode=i.catch=new M(e),t(e)}return n&&(this._currNode=i.finally=new I,this.code(n)),this._endBlockNode(M,I)}throw(e){return this._leafNode(new p(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=i.nil,n,r){return this._blockNode(new x(e,t,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=P;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===i.nil?n:n===i.nil?t:i._`${G(t)} ${e} ${G(n)}`}function G(e){return e instanceof i.Name?e:i._`(${e})`}t.or=function(...e){return e.reduce(O)}},7845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const i=n(1520);class r extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var o;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(o||(t.UsedValueState=o={})),t.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof i.Name?e:this.name(e)}name(e){return new i.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=s;class a extends i.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=i._`.${new i.Name(t)}[${n}]`}}t.ValueScopeName=a;const l=i._`\n`;t.ValueScope=class extends s{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?l:i.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(e),{prefix:r}=i,o=null!==(n=t.key)&&void 0!==n?n:t.ref;let s=this._values[r];if(s){const e=s.get(o);if(e)return e}else s=this._values[r]=new Map;s.set(o,i);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=t.ref,i.setValue(t,{property:r,itemIndex:l}),i}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return i._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,s={},a){let l=i.nil;for(const c in e){const u=e[c];if(!u)continue;const h=s[c]=s[c]||new Map;u.forEach((e=>{if(h.has(e))return;h.set(e,o.Started);let s=n(e);if(s){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;l=i._`${l}${n} ${e} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(e)))throw new r(e);l=i._`${l}${s}${this.opts._n}`}h.set(e,o.Completed)}))}return l}}},8708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const i=n(9029),r=n(4227),o=n(2023);function s(e,t){const n=e.const("err",t);e.if(i._`${o.default.vErrors} === null`,(()=>e.assign(o.default.vErrors,i._`[${n}]`)),i._`${o.default.vErrors}.push(${n})`),e.code(i._`${o.default.errors}++`)}function a(e,t){const{gen:n,validateName:r,schemaEnv:o}=e;o.$async?n.throw(i._`new ${e.ValidationError}(${t})`):(n.assign(i._`${r}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>i.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?i.str`"${e}" keyword must be ${t} ($data)`:i.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,r,o){const{it:l}=e,{gen:u,compositeRule:h,allErrors:d}=l,p=c(e,n,r);(null!=o?o:h||d)?s(u,p):a(l,i._`[${p}]`)},t.reportExtraError=function(e,n=t.keywordError,i){const{it:r}=e,{gen:l,compositeRule:u,allErrors:h}=r;s(l,c(e,n,i)),u||h||a(r,o.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(o.default.errors,t),e.if(i._`${o.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(i._`${o.default.vErrors}.length`,t)),(()=>e.assign(o.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:r,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=e.name("err");e.forRange("i",s,o.default.errors,(s=>{e.const(l,i._`${o.default.vErrors}[${s}]`),e.if(i._`${l}.instancePath === undefined`,(()=>e.assign(i._`${l}.instancePath`,(0,i.strConcat)(o.default.instancePath,a.errorPath)))),e.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(i._`${l}.schema`,n),e.assign(i._`${l}.data`,r))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(e,t,n){const{createErrors:r}=e.it;return!1===r?i._`{}`:function(e,t,n={}){const{gen:r,it:s}=e,a=[u(s,n),h(e,n)];return function(e,{params:t,message:n},r){const{keyword:s,data:a,schemaValue:c,it:u}=e,{opts:h,propertyName:d,topSchemaRef:p,schemaPath:m}=u;r.push([l.keyword,s],[l.params,"function"==typeof t?t(e):t||i._`{}`]),h.messages&&r.push([l.message,"function"==typeof n?n(e):n]),h.verbose&&r.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[o.default.data,a]),d&&r.push([l.propertyName,d])}(e,t,a),r.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?i.str`${e}${(0,r.getErrorPath)(t,r.Type.Str)}`:e;return[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,n)]}function h({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:o}){let s=o?t:i.str`${t}/${e}`;return n&&(s=i.str`${s}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,s]}},3835:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const i=n(9029),r=n(3558),o=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,s.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=d.call(this,e);if(t)return t;const n=(0,s.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:u}=this.opts,h=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:u});let p;e.$async&&(p=h.scopeValue("Error",{ref:r.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=h.scopeName("validate");e.validateName=m;const f={gen:h,allErrors:this.opts.allErrors,data:o.default.data,parentData:o.default.parentData,parentDataProperty:o.default.parentDataProperty,dataNames:[o.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:h.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,i.stringify)(e.schema)}:{ref:e.schema}),validateName:m,ValidationError:p,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:i.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,l.validateFunctionCode)(f),h.optimize(this.opts.code.optimize);const t=h.toString();g=`${h.scopeRefs(o.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${o.default.self}`,`${o.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:t,scopeValues:h._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof i.Name?void 0:e,items:t instanceof i.Name?void 0:t,dynamicProps:e instanceof i.Name,dynamicItems:t instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function h(e){return(0,s.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function d(e){for(const i of this._compilations)if(n=e,(t=i).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return i;var t,n}function p(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||m.call(this,e,t)}function m(e,t){const n=this.opts.uriResolver.parse(t),i=(0,s._getFullPath)(this.opts.uriResolver,n);let r=(0,s.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&i===r)return g.call(this,n,e);const o=(0,s.normalizeId)(i),a=this.refs[o]||this.schemas[o];if("string"==typeof a){const t=m.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),o===(0,s.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,i=t[n];return i&&(r=(0,s.resolveUrl)(this.opts.uriResolver,r,i)),new c({schema:t,schemaId:n,root:e,baseId:r})}return g.call(this,n,a)}}t.SchemaEnv=c,t.compileSchema=u,t.resolveRef=function(e,t,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,t,n);const r=e.refs[n];if(r)return r;let o=p.call(this,e,n);if(void 0===o){const r=null===(i=e.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;r&&(o=new c({schema:r,schemaId:s,root:e,baseId:t}))}return void 0!==o?e.refs[n]=h.call(this,o):void 0},t.getCompilingSchema=d,t.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:i}){var r;if("/"!==(null===(r=e.fragment)||void 0===r?void 0:r[0]))return;for(const i of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(i)];if(void 0===e)return;const r="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(i)&&r&&(t=(0,s.resolveUrl)(this.opts.uriResolver,t,r))}let o;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,s.resolveUrl)(this.opts.uriResolver,t,n.$ref);o=m.call(this,i,e)}const{schemaId:l}=this.opts;return o=o||new c({schema:n,schemaId:l,root:i,baseId:t}),o.schema!==o.root.schema?o:void 0}},2023:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};t.default=r},4551:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(6939);class r extends Error{constructor(e,t,n,r){super(r||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,i.resolveUrl)(e,t,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(e,this.missingRef))}}t.default=r},6939:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const i=n(4227),r=n(2017),o=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!l(e):!!t&&c(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!s.has(n)&&("object"==typeof e[n]&&(0,i.eachItem)(e[n],(e=>t+=c(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=p(t));const i=e.parse(t);return h(e,i)}function h(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=h;const d=/#\/?$/;function p(e){return e?e.replace(d,""):""}t.normalizeId=p,t.resolveUrl=function(e,t,n){return n=p(n),e.resolve(t,n)};const m=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(e[n]||t),a={"":s},l=u(i,s,!1),c={},h=new Set;return o(e,{allKeys:!0},((e,t,i,r)=>{if(void 0===r)return;const o=l+t;let s=a[r];function u(t){const n=this.opts.uriResolver.resolve;if(t=p(s?n(s,t):t),h.has(t))throw f(t);h.add(t);let i=this.refs[t];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(e,i.schema,t):t!==p(o)&&("#"===t[0]?(d(e,c[t],t),c[t]=e):this.refs[t]=o),t}function g(e){if("string"==typeof e){if(!m.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(s=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=s})),c;function d(e,t,n){if(void 0!==t&&!r(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},396:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},4227:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const i=n(9029),r=n(1520);function o(e,t=e.schema){const{opts:n,self:i}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const r=i.RULES.keywords;for(const n in t)r[n]||m(e,`unknown keyword: "${n}"`)}function s(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function l(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:r}){return(o,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?e(o,s,a):t(o,s,a),a):s instanceof i.Name?(t(o,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:r(o,c)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",i._`{}`);return void 0!==t&&h(e,n,t),n}function h(e,t,n){Object.keys(n).forEach((n=>e.assign(i._`${t}${(0,i.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(o(e,t),!s(t,e.self.RULES.all))},t.checkUnknownRules=o,t.schemaHasRules=s,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,r,o){if(!o){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${e}${t}${(0,i.getProperty)(r)}`},t.unescapeFragment=function(e){return l(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=l,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>{e.if(i._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,i._`${n} || {}`),h(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,i._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>e.assign(n,!0===t||i._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=h;const d={};var p;function m(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:d[t.code]||(d[t.code]=new r._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(p||(t.Type=p={})),t.getErrorPath=function(e,t,n){if(e instanceof i.Name){const r=t===p.Num;return n?r?i._`"[" + ${e} + "]"`:i._`"['" + ${e} + "']"`:r?i._`"/" + ${e}`:i._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=m},7887:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>i(e,t)))}function i(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},i){const r=t.RULES.types[i];return r&&!0!==r&&n(e,r)},t.shouldUseGroup=n,t.shouldUseRule=i},8727:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const i=n(8708),r=n(9029),o=n(2023),s={message:"boolean schema is false"};function a(e,t){const{gen:n,data:r}=e,o={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,i.reportError)(o,s,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:i}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(o.default.data):(t.assign(r._`${i}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:i}=e;!1===i?(n.var(t,!1),a(e)):n.var(t,!0)}},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const i=n(396),r=n(7887),o=n(8708),s=n(9029),a=n(4227);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(i.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l||(t.DataType=l={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:i,opts:o}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,o.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,r.schemaHasRulesForType)(e,t[0]));if(c){const r=d(t,i,o.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(e,t,n){const{gen:i,data:r,opts:o}=e,a=i.let("dataType",s._`typeof ${r}`),l=i.let("coerced",s._`undefined`);"array"===o.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>i.assign(r,s._`${r}[0]`).assign(a,s._`typeof ${r}`).if(d(t,r,o.strictNumbers),(()=>i.assign(l,r))))),i.if(s._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===o.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${r}`).elseIf(s._`${r} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${r} === null
1
+ var bio;(()=>{var e={8924:(e,t,n)=>{"use strict";n.d(t,{X:()=>r});var i=n(7362);class r extends i.e{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in r.aaSynonyms?r.aaSynonyms[e]:e;return super.get(t)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(e="grok"){switch(e){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",i="";for(const r of e)"("==r?t++:")"==r?t--:t?n+=r:i+=r;return isNaN(parseInt(n))?[i,n]:[i,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[i,r]=this.getInnerOuter(e);if(i=i.length>6?`${i.slice(0,3)}...`:i,r=r.length>6?`${r.slice(0,3)}...`:r,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,r,1]:[this.undefinedColor,i,r,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,r,2]:[this.undefinedColor,i,r,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,r,3]:[this.undefinedColor,i,r,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,r,4]:[this.undefinedColor,i,r,4]}return[this.undefinedColor,i,r,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6717:(e,t,n)=>{"use strict";n.d(t,{j:()=>r});var i=n(6082);async function r(){const e=i.Func.find({package:"Chem",name:"getRdKitModule"});if(0===e.length)throw new Error('Package "Chem" must be installed for getRdKitModule.');return(await e[0].prepare().call()).getOutputParamValue()}},9124:(e,t,n)=>{"use strict";n.d(t,{b:()=>o});var i=n(7389),r=n(6082);async function o(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}r.JsInputBase,i.input.helmAsync=async function(e,t){return(await o()).createHelmInput(e,t)}},4356:(e,t,n)=>{"use strict";n.d(t,{Es:()=>s,Eu:()=>c,so:()=>o,ub:()=>l});var i=n(4328);const r="Libraries",o="System:AppData/Bio/monomer-libraries/",s="System:AppData/Bio/monomer-sets/";let a=Promise.resolve();async function l(){let e;return a=a.then((async()=>{const t=await i.dapi.userDataStorage.getValue(r,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[],duplicateMonomerPreferences:{}},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],e.duplicateMonomerPreferences=e.duplicateMonomerPreferences instanceof Object?e.duplicateMonomerPreferences:{},console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await a,e}async function c(e){a=a.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await i.dapi.userDataStorage.postValue(r,"Settings",JSON.stringify(e),!0)})),await a}},6718:(e,t,n)=>{"use strict";n.d(t,{A7:()=>p,pj:()=>u,uL:()=>h,uX:()=>c});var i=n(6082),r=n(4328),o=n(6295),s=n(3151),a=n(2738),l=(n(826),n(3077));function c(e){const t=[];for(let n=0;n<e.rowCount;n++){const i={};Object.keys(s.Ec).forEach((t=>{if("symbol"===t){const r=e.get(s.Ec[t],n);i[t]="."===r?e.get(s.yw,n):r}else if("rgroups"===t){const r=e.get(s.Ec[t],n).split("\n"),o=[];r.forEach((e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),i=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${i}][H]`:`O[*:${i}]`,t.alternateId="H"===n?`R${i}-H`:`R${i}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${i}`,o.push(t)})),i[t]=o}else s.Ec[t]&&(i[t]=e.get(s.Ec[t],n))})),i.author??(i.author=""),i.id??(i.id=0),i.smiles??(i.smiles=""),i.monomerType??(i.monomerType="Backbone"),i.createDate??(i.createDate=null),t.push(i)}return t}async function u(){const e=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function h(e,t){e instanceof i.Column&&(e=(0,l.R)(e).columns.toList());const n=(await u()).getMonomerLib(),o=new Array(e.length),s=e[0].length,c=new Float32Array(s);for(let l=0;l<e.length;++l){const u=l<t.length?t.getCanonical(l):a._S,h=n.getMonomer("PEPTIDE",u)?.smiles??"",d=e[l],p=d.getRawData(),m=d.categories,f=m.indexOf("");if(o[l]={categories:m,data:p,emptyIndex:f},void 0===u)continue;const g=i.Column.fromStrings("smiles",m.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(i.DataFrame.fromColumns([g]),await r.chem.getSimilarities(g,h)),b=y?y.getRawData():null;for(let e=0;e<s;++e){const t=p[e];u!==a._S&&t!==f?c[e]+=b[t]:u===a._S&&t===f&&(c[e]+=1)}}for(let n=0;n<c.length;++n){let r=c[n]/t.length;for(let s=0;s<e.length;++s){const e=o[s];if(s>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&s<t.length){r=i.FLOAT_NULL;break}}c[n]=r}return i.Column.fromFloat32Array("Similarity",c)}async function d(e){const t=(await u()).getMonomerLib(),n=[],o={},s=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=i.Column.fromStrings("smiles",s);for(let t=0;t<s.length;++t){o[e[t]]=t;const i=s[t],l=""===i?new Array(s.length).fill(0):(await r.chem.getSimilarities(a,i)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:o}}async function p(e,t="Morgan"){const n=(await u()).getMonomerLib(),r=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),s={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.molfile||n.getMonomer("PEPTIDE",e)?.smiles||"")),l=i.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(e);const c=i.Column.fromStrings("smiles",a),h=(i.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await d(e);for(let t=0;t<h.length;++t)if(r[t][t]=1,s[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(r[t][e]=r[e][t]=(0,o.$1)(h[t],h[e]));return{scoringMatrix:r,alphabetIndexes:s}}},7384:(e,t,n)=>{"use strict";n.d(t,{C4:()=>d});var i=n(4328),r=n(6082),o=n(1991),s=n.n(o),a=n(439),l=n(826);const c={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(3151);function h(e){return Math.round(c.PRECISION_FACTOR*e)/c.PRECISION_FACTOR}async function d(e,t,o){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==r.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let h=t;const d=l.GO.forColumn(t);d.isHelm()&&(h=d.convert(a.Hi.SEPARATOR,"."),h.name=t.name);const m=l.GO.forColumn(h).alphabet;let f;if(m===a.YI.PT||m===a.YI.UN)f="PEPTIDE";else{if(m!==a.YI.RNA&&m!==a.YI.DNA)return{col:null,warnings:[`Unexpected column's '${h.name}' alphabet '${m}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),r=l.GO.forColumn(e);let o=!1;for(let e=0;e<t;++e){const t=r.getSplitted(e);o||(o=0===t.length),n[e]=s()(t.canonicals).filter((e=>!r.isGap(e))).map((e=>e)).toArray()}return o&&i.shell.warning(`Some values in the "${e.name}" column are empty`),n}(h),y=await async function(e,t,n,r){const o=function(e,t,n){const i=new Map;for(const r of e.getMonomerSymbolsByType(t)){const o=e.getMonomer(t,r);if("RNA"===t&&("Branch"===o.monomerType||n===a.YI.DNA&&o.symbol===c.DEOXYRIBOSE||n===a.YI.RNA&&o.symbol===c.RIBOSE||o.symbol===c.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==o.monomerType){const e={};u.f6.forEach((t=>{e[t]=o[t]})),i.set(o.symbol,e)}}return i}(t,n,r),s=new Map,l=await i.functions.call("Chem:getRdKitModule"),h={value:null};if("RNA"===n){const e=r===a.YI.RNA?[c.RIBOSE,c.PHOSPHATE]:[c.DEOXYRIBOSE,c.PHOSPHATE];for(const t of e)p(s,t,o,l,n,h)}for(let t=0;t<e.length;++t){const i=e[t];for(const e of i)if(""!==e)try{p(s,e,o,l,n,h)}catch(t){const n=t instanceof Error?t.message:t.toString(),i=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${i}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return s}(g,o,f,m),b=h.length,{molfileList:v,molfileWarningList:w}=await async function(e,t,i,r,o){const s=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(s).fill(null).map((()=>new Worker(new URL(n.p+n.u(248),n.b)))),l=o/s;let c=[],u=[];const h=new Array(s);for(let n=0;n<s;n++){const c=Math.floor(n*l),u=n===s-1?o:Math.floor((n+1)*l);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:i,polymerType:r,start:c,end:u}),h[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(h)).forEach((e=>{c=c.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:c,molfileWarningList:u}}(g,y,m,f,b);if(w.length>.05*b)throw new Error("Too many errors getting molfiles.");const C=`molfile(${h.name})`,A=e.columns.getUnusedName(C),S=r.Column.fromStrings(A,v);return S.semType=r.SEMTYPE.MOLECULE,S.meta.units=r.UNITS.Molecule.MOLBLOCK,{col:S,warnings:w}}function p(e,t,n,i,r,o){if(!e.has(t)){const s=function(e,t,n,i,r){if(t.has(e)){const s=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(s.rgroups),l=(o=s.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let i;for(;null!==(i=n.exec(e));)i.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(i[1]),parseInt(i[3]));return t}(o):function(e){const t=new Map;let n=e.indexOf(c.V2K_A_LINE,0),i=n;for(;-1!==n;){i=e.indexOf("\n",n);const r=parseInt(e.substring(n,i).replace(/^A\s+/,""));n=e.indexOf("R",i),i=e.indexOf("\n",n);const o=parseInt(e.substring(n,i).replace(/^R/,""));t.set(r,o),n=e.indexOf(c.V2K_A_LINE,i)}for(n=e.indexOf(c.V2K_RGP_LINE,0),i=e.indexOf("\n",n);-1!==n;){n+=c.V2K_RGP_SHIFT,i=e.indexOf("\n",n);const r=e.substring(n,i).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<r.length;e+=2){if(t.has(r[e])&&t.get(r[e])!==r[e+1])throw new Error(`r-group index ${r[e]} has already been added with a different value`);t.set(r[e],r[e+1])}n=e.indexOf(c.V2K_RGP_LINE,i)}return t}(o),u=s.molfile.includes("V3000")?s.molfile:function(e,t){const n=t.get_mol(e),i=n.get_v3Kmolblock();return n.delete(),i}(function(e){let t=e.indexOf(c.V2K_A_LINE,0);-1===t&&(t=e.indexOf(c.V2K_RGP_LINE));const n=e.indexOf(c.V3K_END,t);return e.substring(0,t)+e.substring(n)}(s.molfile),n),d=function(e){let t=(e=e.replaceAll("\r","")).indexOf(c.V3K_BEGIN_COUNTS_LINE)+c.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const i=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:i,bondCount:parseInt(e.substring(t,n))}}(u),p=function(e,t){const n=new Array(t),i=new Float32Array(t),r=new Float32Array(t),o=new Array(t);let s=e.indexOf(c.V3K_BEGIN_ATOM_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;l++){s=e.indexOf(c.V3K_BEGIN_DATA_LINE,s)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",s),s=a+1,a=e.indexOf(" ",s),n[l]=e.substring(s,a);const t=new Array(2);for(let n=0;n<2;++n)s=a+1,a=e.indexOf(" ",s),t[n]=parseFloat(e.substring(s,a));i[l]=t[0],r[l]=t[1],s=a,a=e.indexOf("\n",s)+1,o[l]=e.slice(s,a),s=a}return{atomTypes:n,x:i,y:r,kwargs:o}}(u,d.atomCount),g=function(e,t){const n=new Uint32Array(t),i=new Array(t),r=new Map,o=new Map;let s=e.indexOf(c.V3K_BEGIN_BOND_BLOCK);s=e.indexOf("\n",s);let a=s;for(let l=0;l<t;++l){const t=new Array(3);s=e.indexOf(c.V3K_BEGIN_DATA_LINE,a)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",s);for(let n=0;n<3;++n)s=a+1,a=Math.min(e.indexOf("\n",s),e.indexOf(" ",s)),t[n]=parseInt(e.slice(s,a));n[l]=t[0],i[l]=t.slice(1);const u=e.indexOf("\n",s);let h=e.slice(a,u),d=h.indexOf(c.V3K_BOND_CONFIG);if(-1!==d){d=h.indexOf("=",d)+1;let e=h.indexOf(" ",d);-1===e&&(e=h.length);const t=parseInt(h.slice(d,e));r.set(l,t);const n=c.V3K_BOND_CONFIG+t.toString();h=h.replace(n,"")}h||o.set(l,h)}return{bondTypes:n,atomPairs:i,bondConfiguration:r,kwargs:o}}(u,d.bondCount),b=function(e,t,n,i){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[i,r]of n)e.atomTypes[i-1]=t[r-1]}(e,n,i),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const i of[1,2])if(e.get(t.rNodes[n])===i){const e=t.rNodes[i-1];t.rNodes[i-1]=t.rNodes[n],t.rNodes[n]=e}}(i,r),m(t,r),r}(p,g,a,l),S=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const i=e.indexOf(")",n);t=t.concat(e.substring(n,i).split(" ").slice(1).map((e=>parseInt(e)))),n=i,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),x={atoms:p,bonds:g,meta:b,stereoAtoms:S};return"PEPTIDE"===i?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;A(e,-i[t],-r[t]);const o=v(i[n],r[n]);w(e.atoms,-o),i[e.meta.rNodes[1]-1]<0&&function(e){C(e,!1)}(e);const s=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const i=n[e],r=n[(e+1)%2];t.has(i)?t.get(i)?.push(r):t.set(i,new Array(1).fill(r))}return t}(e);let n=0;const i=e.atoms.atomTypes.length;let r=0;for(;0===n;){const o=t.get(e.meta.terminalNodes[1])[r];if(e.atoms.atomTypes[o-1]===c.OXYGEN&&o!==e.meta.rNodes[1]&&(n=o),r++,r>i)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${i}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){C(e,!0)}(e),w(e.atoms,-function(e,t){return v(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,s),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const i=t-1,r=n-1,o=e.atoms.x,s=e.atoms.y,a=o[i],l=s[i];o[i]=o[r],s[i]=s[r],o[r]=a,s[r]=l}(e,t,e.meta.rNodes[1])}(e,s)}(x):e===c.RIBOSE||e===c.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,i=e.atoms.y;let r=e.meta.terminalNodes[0]-1;const o=e.meta.rNodes[1]-1;A(e,-n[r],-i[r]);const s=v(n[o],i[o]);w(e.atoms,3*Math.PI/2-s),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,i=e.meta.rNodes[2]-1,r=e.meta.terminalNodes[2]-1,o=t[i]-t[r],s=n[i]-n[r];return Math.atan(s/o)+Math.PI/2}(e),r=e.meta.terminalNodes[0]-1,A(e,-n[r],-i[r])}(x,r):e===c.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,i=e.atoms.x,r=e.atoms.y;A(e,-i[t],-r[t]);const o=v(i[n],r[n]);w(e.atoms,Math.PI/2-o)}(x):function(e,t){const n=e.atoms.x,i=e.atoms.y,r=e.meta.terminalNodes[0]-1,o=e.meta.rNodes[0]-1;A(e,-n[r],-i[r]);const s=v(n[o],i[o]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");w(e.atoms,Math.PI-s+a);const l=function(e,t){return h(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:i[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:i[e.meta.terminalNodes[0]-1]});if(1!=l)for(let e=0;e<n.length;++e)n[e]=h(n[e]/l),i[e]=h(i[e]/l)}(x,r),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===c.RIBOSE||n===c.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],m(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===c.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],A(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(i,x,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===c.HYDROGEN&&(y(e,t+1),--t),++t}(x),x}var o;return null}(t,n,i,r,o);if(!s)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,s)}}function m(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const i=t.terminalNodes,r=e.atomPairs;let o=0,s=0;for(;o<r.length&&s<i.length;){for(let e=0;e<i.length;++e)for(let t=0;t<2;++t)r[o][t]===n[e]&&(i[e]=r[o][(t+1)%2],n.length,++s);++o}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[h(e.atoms.x[t]-e.atoms.x[n]),h(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,i=e.atoms,r=e.bonds,o=e.meta;i.atomTypes.splice(n,1),i.x=b(Float32Array,i.x,n,1),i.y=b(Float32Array,i.y,n,1),i.kwargs.splice(n,1);for(let e=0;e<o.terminalNodes.length;++e)o.terminalNodes[e]>t?--o.terminalNodes[e]:o.terminalNodes[e]===t&&(o.terminalNodes[e]=-1);for(let e=0;e<o.rNodes.length;++e)o.rNodes[e]>t?--o.rNodes[e]:o.rNodes[e]===t&&(o.rNodes[e]=-1);let s=0;for(;s<r.atomPairs.length;){const e=r.atomPairs[s][0],n=r.atomPairs[s][1];e===t||n===t?(r.atomPairs.splice(s,1),r.bondTypes=b(Uint32Array,r.bondTypes,s,1),r.bondConfiguration.has(s)&&r.bondConfiguration.delete(s),r.kwargs.has(s)&&r.kwargs.delete(s),--s):(r.atomPairs[s][0]=e>t?e-1:e,r.atomPairs[s][1]=n>t?n-1:n),++s}let a=Array.from(r.bondConfiguration.keys());a.forEach((e=>{if(r.bondConfiguration.has(e)&&e>n){const t=r.bondConfiguration.get(e);r.bondConfiguration.delete(e),r.bondConfiguration.set(e-1,t)}})),a=Array.from(r.kwargs.keys()),a.forEach((e=>{if(r.kwargs.has(e)&&e>n){const t=r.kwargs.get(e);r.kwargs.delete(e),r.kwargs.set(e-1,t)}}))}}function b(e,t,n,i){const r=new e(t.length-i);let o=0,s=0;for(;o<t.length;)o===n&&(o+=i),r[s]=t[o],++s,++o;return r}function v(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const i=t/e,r=Math.atan(i);n=e<0?Math.PI/2+r:-Math.PI/2+r}return n}function w(e,t){if(0!==t){const n=e.x,i=e.y,r=Math.cos(t),o=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=h(t*r-i[e]*o),i[e]=h(t*o+i[e]*r)}}}function C(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const i=1===t?3:1;n.set(e,i)}}function A(e,t,n){const i=e.atoms.x,r=e.atoms.y;for(let e=0;e<i.length;++e)i[e]=h(i[e]+t),void 0!==n&&(r[e]=h(r[e]+n))}},1093:(e,t,n)=>{"use strict";n.d(t,{A:()=>r});var i=n(7362);class r extends i.e{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new r({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class o{}o.SemType="Nucleotides",o.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",o.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},7362:(e,t,n)=>{"use strict";n.d(t,{e:()=>i});class i{static makePalette(e,t=!1,n=i){const r={};return e.forEach((e=>{const n=e[0],i=e[1];n.forEach(((e,n)=>{r[e]=this.colourPalette[i][t?0:n]}))})),new n(r)}constructor(e){this._palette=e}get(e,t){return this._palette[e]}}i.undefinedColor="rgb(100,100,100)",i.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},4152:(e,t,n)=>{"use strict";n.d(t,{oT:()=>h});var i=n(6082),r=n(7362),o=n(6718);function s(e){if(null==e)return"rgb(100,100,100)";const t=i.Color.fromHtml(e),n=i.Color.g(t),r=i.Color.r(t),o=i.Color.b(t),s=Math.sqrt(Math.pow(0-r,2)+Math.pow(0-n,2)+Math.pow(0-o,2));return s>210?`rgb(${r/s*210},${n/s*210},${o/s*210})`:i.Color.toRgb(t)}class a{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class l{}class c extends l{get(e,t){return"#666666"}}class u extends l{static buildPalette(){return(0,o.pj)().then((e=>{e.awaitLoaded().then((()=>{const t=e.getMonomerLib();t.onChanged.subscribe((()=>{u.customMonomerColors={},u.polymerTypes=t.getPolymerTypes();for(const e of this.polymerTypes){const n=t.getMonomerSymbolsByType(e);for(const i of n){const n=t.getMonomer(e,i);n?.meta?.colors?.default?.background&&(this.customMonomerColors[i]||(this.customMonomerColors[i]={}),this.customMonomerColors[i][e]=s(n.meta.colors.default.background))}}}))}))})),[].concat(...Object.values(r.e.colourPalette))}get(e,t){const n=u.customMonomerColors[e],i=t??"PEPTIDE";if(n&&n[i])return n[i];const r=a.hashCode(e)%u.palette.length;return s(u.palette[r])}}u.palette=u.buildPalette(),u.customMonomerColors={},u.polymerTypes=[];class h extends r.e{static get Gray(){return void 0===this.gray&&(this.gray=new c),this.gray}static get Color(){return void 0===this.color&&(this.color=new u),this.color}}},6642:(e,t,n)=>{"use strict";n.d(t,{h:()=>s,s:()=>a});var i=n(4328),r=n(1858),o=n(8070);function s(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const i=e.cell.column;if(t=t??i.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,i,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.dirty=!0,this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{this.dirty=!0}))),this.tableCol&&this.subs.push(i.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(i.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}reset(){this.dirty=!1}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,o.PE)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},6882:(e,t,n)=>{"use strict";n.d(t,{J:()=>u});var i=n(6082),r=n(1991),o=n.n(r),s=n(826),a=n(6642),l=n(6718),c=n(9192);class u extends a.s{constructor(e,t,n,r,o){super(e,t,n),this.monomerLengthLimit=r,this.propsProvider=o,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=i.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,l.pj)().then((e=>{if(this.destroyed)return;const t=e.getMonomerLib();this.subs.push(t.onChanged.subscribe((()=>{this.dirty=!0,this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=i.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={},super.reset()}getCellMonomerLengths(e,t){if(this.colWidth<t&&(this.colWidth=t,this.dirty=!0),this.dirty)try{this.reset()}catch(e){const[t,n]=(0,c.AP)(e);this.logger.error(t,void 0,n)}const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),i=new Array(n.length+1);i[0]=5;for(let e=1;e<i.length;e++)i[e]=i[e-1]+n[e-1];return[n,i]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),i=s.GO.forColumn(this.tableCol).getSplitted(e).originals,r=Math.min(n,i.length);let o=this._monomerLengthList[e];if(null===o||o.length<r){o=this._monomerLengthList[e]=new Array(i.length);let t=0;for(let e=0;e<r;++e){const n=i[e],r=this.props.monomerToShort(n,this.monomerLengthLimit),s=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.monomerCharWidth;if(o[e]=s,t+=s,t>this.colWidth)break}}return o}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:i}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.monomerCharWidth,o=Math.ceil(this.colWidth/r);for(let e=n;e<i;e++){if(this._processedRows.get(e)&&o<=this._processedMaxVisibleSeqLength)continue;const n=s.GO.forColumn(this.tableCol).getSplitted(e,o).originals,i=Math.min(o,n.length);i>t.length&&t.push(...new Array(i-t.length).fill(r));let a=0;for(let e=0;e<i;++e){const i=n[e],r=this.props.monomerToShort(i,this.monomerLengthLimit),o=this.props.separatorWidth+r.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,o),a+=o,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,o)}return t}getPosition(e,t,n){const[i,r]=this.getCellMonomerLengths(e,n),a=s.GO.forColumn(this.tableCol);return 0===o()(a.getSplitted(e).originals).toArray().length?null:function(e,t){let n,i=100,r=0,o=e.length-1;for(;r<=o;){if(n=Math.floor((o+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?o=n-1:r=n+1,--i<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.dirty=!0}setSeparatorWidth(e){this.props.separatorWidth=e,this.dirty=!0}isMsa(){return this.props.seqHandler.isMsa()}}},3151:(e,t,n)=>{"use strict";n.d(t,{EK:()=>l,Ec:()=>o,f6:()=>i,pe:()=>s,q7:()=>a,yw:()=>r});const i=["symbol","molfile","rgroups","name"],r="MonomerName",o={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},s={monomerType:"Backbone",smiles:"",name:"",author:"Datagrok",molfile:"",naturalAnalog:"",rgroups:[],createDate:null,id:0,polymerType:"PEPTIDE",symbol:""},a="p",l=new RegExp(`[rd]\\((\\w)\\)${a}?`,"g")},9192:(e,t,n)=>{"use strict";function i(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?i(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function r(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):void 0}function o(e){return[i(e),r(e)]}n.d(t,{AP:()=>o})},3516:(e,t,n)=>{"use strict";n.d(t,{m:()=>s});var i=n(6082),r=n(826),o=n(439);class s{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const i=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(i),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=i.Column.fromStrings("description",this.descriptionsArray),t=i.Column.fromStrings("sequence",this.sequencesArray);return t.semType=i.SEMTYPE.MACROMOLECULE,t.meta.units=o.Hi.FASTA,r.GO.forColumn(t),[i.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},6873:(e,t,n)=>{"use strict";n.d(t,{Hx:()=>u,dW:()=>c});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(826),l=n(9322);function c(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=i.Column.fromList(i.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=i.SEMTYPE.MACROMOLECULE,n.meta.units=s.Hi.SEPARATOR,n.setTag(s.gp.separator,"/"),n.setTag(s.gp.alphabet,s.YI.UN),n.setTag(s.gp.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(i.Column.fromList(i.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function u(e=s.Hi.SEPARATOR,t=s.YI.PT,n=(e===s.Hi.SEPARATOR?"-":void 0),r=void 0,c="seq",u=100,h=10**6){const d=t===s.YI.UN?r?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,s.Qf)(t)),p=d.length,m=i.Column.fromType(i.COLUMN_TYPE.STRING,c,u);m.semType=i.SEMTYPE.MACROMOLECULE,m.meta.units=e,m.setTag(s.gp.alphabet,t),e==s.Hi.SEPARATOR&&m.setTag(s.gp.separator,n);const f=a.GO.forColumn(m);for(let t=0;t<u;t++){const n=o().count(0).take(h).map((e=>d[Math.floor(Math.random()*p)])).toArray(),i=f.joiner(new l.Mu(n,a.b9[e]));m.set(t,i)}return m}},439:(e,t,n)=>{"use strict";n.d(t,{B5:()=>l,Hi:()=>i,Vl:()=>c,YI:()=>r,gp:()=>o,q7:()=>u,z1:()=>a});var i,r,o,s=n(2738);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(i||(i={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(r||(r={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(o||(o={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new s.aD(r.PT,c.fasta.peptide,.5),new s.aD(r.DNA,c.fasta.dna,.55),new s.aD(r.RNA,c.fasta.rna,.55)]},2003:(e,t,n)=>{"use strict";n.d(t,{Hi:()=>i.Hi,J9:()=>r.J9,Qf:()=>r.Qf,SM:()=>r.SM,YI:()=>i.YI,dh:()=>r.dh,gp:()=>i.gp,mn:()=>r.mn,ny:()=>r.ny,q7:()=>i.q7,qp:()=>r.qp,z1:()=>i.z1,zS:()=>r.zS});var i=n(439),r=n(9322)},2738:(e,t,n)=>{"use strict";n.d(t,{XN:()=>o,_S:()=>i,aD:()=>r});const i="";class r{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class o extends r{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},9322:(e,t,n)=>{"use strict";n.d(t,{Mu:()=>m,pc:()=>_,Qf:()=>E,ny:()=>I,Iv:()=>A,dh:()=>b,zS:()=>x,SM:()=>M,mn:()=>T,J9:()=>g,tm:()=>y,qp:()=>C});var i=n(6082),r=n(1991),o=n.n(r),s=n(2738),a=n(439),l=n(826);class c extends Float32Array{}var u=n(3629),h=n(8924),d=n(1093),p=n(4152);class m{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===l.b9[a.Hi.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?s._S:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}const g=e=>{const t=o()(e.toString().matchAll(a.B5)).map((e=>e[2]??e[1])).toArray();return new m(t,l.b9[a.Hi.FASTA])},y=e=>e?new f(e):new m([],l.b9[a.Hi.FASTA]);function b(e,t=void 0){return n=>{if(n){let i;const r=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){r.lastIndex=0,i=new Array(Math.ceil(t));let e=null,o=0;for(;null!==(e=r.exec(n))&&o<t;)i[o++]=e[0].replace('"-"',"").replace("'-'","");i.splice(o)}else i=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new m(i,l.b9[a.Hi.SEPARATOR])}return new m([],l.b9[a.Hi.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g,C=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,i=n?n.split("."):[];return new m(i.map((e=>{w.lastIndex=0;const t=w.exec(e);return t&&t.length>=2?t[1]:e})),l.b9[a.Hi.HELM])};function A(e,t,n=void 0){if(e.toLowerCase().startsWith(a.Hi.FASTA))return g;if(e.toLowerCase().startsWith(a.Hi.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.Hi.HELM))return C;throw new Error(`Unexpected units ${e} .`)}const S=/([^\W_]+)/g;function x(e,t){if(e.length<=t)return e;const n=e.match(S),i=e.length>t||(n?.length??0)>1,r=n?.[0]??" ";return i?r.substring(0,t-1)+"…":r}function E(e){switch(e){case a.YI.DNA:return a.Vl.fasta.dna;case a.YI.RNA:return a.Vl.fasta.rna;case a.YI.PT:return a.Vl.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function _(e,t,n="-"){const i=t.map((t=>{const i=function(e,t,n="-"){const i=new Set([...new Set(Object.keys(e)),...t]);i.delete(n);const r=[],o=[];for(const n of i)r.push(n in e?e[n]:0),o.push(t.has(n)?1:0);const s=new c(r),a=new c(o);return(0,u.KE)(s,a)/((0,u.wQ)(s)*(0,u.wQ)(a))}(e,t.alphabet,n);return new s.XN(t,e,i)}));let r;const o=Math.max(...i.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return r=o>0?i.find((e=>e.similarity===o)).name:a.YI.UN,r}function M(e,t=5){let n;if(e.semType==i.SEMTYPE.MACROMOLECULE)n=l.GO.forColumn(e).alphabet;else{const i=function(e,t,n){const i=e.categories;return function(e,t){const n={};let i=!0,r=null;for(const o of e)if(null==r?r=o.length:o.length!==r&&(i=!1),o.length>=t)for(const e of o.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:i}}(o().enumerate(e.getRawData()).map((([e,t])=>n(i[e]))),t)}(e,t,g);n=_(i.freq,a.q7)}return I(n)}function I(e){switch(e){case a.YI.PT:return h.X.GrokGroups;case a.YI.DNA:case a.YI.RNA:return d.A.Chromatogram;default:return p.oT.Color}}function T(e){const t=e.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.meta.units;return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},826:(e,t,n)=>{"use strict";n.d(t,{GO:()=>m,b9:()=>p,j8:()=>d});var i=n(6082),r=n(1991),o=n.n(r),s=n(2003),a=n(2738),l=n(9322),c=n(6863),u=n(6718),h=n(3151);const d=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},p={[s.Hi.FASTA]:"-",[s.Hi.SEPARATOR]:"",[s.Hi.HELM]:"*"};class m{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==i.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${i.TYPE.STRING}'.`);this._column=e;const t=this._column.meta.units;if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?p[s.Hi.FASTA]:this.isHelm()?p[s.Hi.HELM]:p[s.Hi.SEPARATOR],!this.column.tags.has(s.gp.aligned)||!this.column.tags.has(s.gp.alphabet)||!this.column.tags.has(s.gp.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===s.YI.UN)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(s.gp.separator);m.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.meta.units}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(s.gp.alphabetIsMultichar))if(this.isHelm())this.column.setTag(s.gp.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${s.gp.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[d.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE||e.column.meta.units!==s.Hi.FASTA)throw new Error(`The column of notation '${s.Hi.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);e.column.meta.units=s.Hi.FASTA,m.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE||e.column.meta.units!==s.Hi.SEPARATOR)throw new Error(`The column of notation '${s.Hi.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${s.Hi.SEPARATOR}' must have the separator tag.`);e.column.meta.units=s.Hi.SEPARATOR,e.column.setTag(s.gp.separator,t),m.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${s.Hi.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);e.column.meta.units=s.Hi.HELM,m.setTags(e)}static setTags(e){const t=e.column.meta.units;if([s.Hi.FASTA,s.Hi.SEPARATOR].includes(t)){if(!e.column.getTag(s.gp.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(s.gp.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(s.gp.aligned,t));let n=e.column.getTag(s.gp.alphabet);if(null===n&&(n=(0,l.pc)(e.stats.freq,s.q7),e.column.setTag(s.gp.alphabet,n)),n===s.YI.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(s.gp.alphabetSize,t.toString()),e.column.setTag(s.gp.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(s.gp.separator)??void 0;if(this.notation===s.Hi.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(s.gp.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(s.gp.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(s.gp.isHelmCompatible)}getAlphabetSize(){if(this.notation==s.Hi.HELM||this.alphabet==s.YI.UN){const e=this.column.getTag(s.gp.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case s.YI.PT:return 20;case s.YI.DNA:case s.YI.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===s.Hi.HELM||this.alphabet===s.YI.UN&&"true"===this.column.getTag(s.gp.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}async getHelm(e,t){const n=this.column.get(e);return this.notationProvider?(await this.notationProvider.getHelm(this.column,t)).get(e):this.convertToHelm(n)}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const i=this.column.length;for(let r=0;r<i;++r){const i=this.getSplitted(r);null==n?n=i.length:i.length!==n&&(t=!1);for(const t of i.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...o().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(s.gp.positionNames);this._posList=e?e.split(s.z1).map((e=>e.trim())):o().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===s.Hi.FASTA}isSeparator(){return this.notation===s.Hi.SEPARATOR}isHelm(){return this.notation===s.Hi.HELM}isRna(){return this.alphabet===s.YI.RNA}isDna(){return this.alphabet===s.YI.DNA}isPeptide(){return this.alphabet===s.YI.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(s.Hi.FASTA))return s.Hi.FASTA;if(this.units.toLowerCase().startsWith(s.Hi.SEPARATOR))return s.Hi.SEPARATOR;if(this.units.toLowerCase().startsWith(s.Hi.HELM))return s.Hi.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,r){const o=this.column,a=e.toLowerCase()+"("+o.name+")",l=n??o.dataFrame.columns.getUnusedName(a),c=i.Column.fromList("string",l,r??new Array(this.column.length).fill(""));if(c.semType=i.SEMTYPE.MACROMOLECULE,c.meta.units=e,e===s.Hi.SEPARATOR){if(!t)throw new Error(`Notation '${s.Hi.SEPARATOR}' requires separator value.`);c.setTag(s.gp.separator,t)}c.setTag(i.TAGS.CELL_RENDERER,e===s.Hi.HELM?"helm":"sequence");const u=o.getTag(s.gp.aligned);u&&c.setTag(s.gp.aligned,u);let h=o.getTag(s.gp.alphabet);h||this.notation!==s.Hi.HELM||e===s.Hi.HELM||(h=s.YI.UN),null!=h&&c.setTag(s.gp.alphabet,h);let d=o.getTag(s.gp.alphabetSize);null!=h&&d&&c.setTag(s.gp.alphabetSize,d);const p=o.getTag(s.gp.alphabetIsMultichar);return null!=h&&void 0!==p&&c.setTag(s.gp.alphabetIsMultichar,p),e==s.Hi.HELM&&(d=this.getAlphabetSize().toString(),c.setTag(s.gp.alphabetSize,d)),c}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=m.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[s.Hi.FASTA,s.Hi.SEPARATOR,s.Hi.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!m.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const r=i.Column.fromList("string",t,new Array(e).fill(""));return r.semType=i.SEMTYPE.MACROMOLECULE,r.meta.units=n,r}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(s.Hi.FASTA))return null===this.column.getTag(s.gp.alphabet)||this.getAlphabetIsMultichar()?s.J9:l.tm;if(this.units.toLowerCase().startsWith(s.Hi.SEPARATOR))return(0,s.dh)(this.separator,e);if(this.units.toLowerCase().startsWith(s.Hi.HELM))return s.qp;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return c.Z.HAMMING;switch(this.alphabet){case s.YI.DNA:case s.YI.RNA:case s.YI.PT:}return c.Z.LEVENSHTEIN}getDistanceFunction(){return c.V[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(s.gp.isHelmCompatible))return"true"===this.column.getTag(s.gp.isHelmCompatible);const e=(await(0,u.pj)()).getMonomerLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,s.dh)(this.separator),new Set),i=this.column.length,r=this.column.getRawData();for(let e=0;e<i;++e){const i=r[e];if(!(i in n)){n.add(i);const r=this.getSplitted(e);for(const e of r.canonicals)if(!t.has(e))return this.column.setTag(s.gp.isHelmCompatible,"false"),!1}}return this.column.setTag(s.gp.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===s.Hi.FASTA}toSeparator(e){return e===s.Hi.SEPARATOR}toHelm(e){return e===s.Hi.HELM}convertHelmToFastaSeparator(e,t,n,i){i||(i=this.toFasta(t)?p[s.Hi.FASTA]:p[s.Hi.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),o=this.splitter(e),a=[];for(let e=0;e<o.length;++e){let n=o.getOriginal(e);if(r&&(n=n.replace(h.EK,"")),n===p[s.Hi.HELM])a.push(i);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),i=this.getNewColumn(e,t);return i.init((e=>{const t=this.getSplitted(e);return n(t)})),i}getRegion(e,t,n){const i=this.getNewColumn(this.notation,this.separator);i.name=n;const r=e??0,o=t??this.maxLength-1,a=this.getJoiner(),c=o-r+1,u=p[this.notation];i.init((e=>{const t=this.getSplitted(e),n=new Array(c);for(let e=0;e<c;++e){const i=r+e;n[e]=i<t.length?t.getOriginal(i):u}return a(new l.Mu(n,u))}));const h=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(c);for(let e=0;e<c;++e){const i=r+e;n[e]=i<t.length?t[i]:"?"}return n.join(s.z1)},d=this.column.getTag(s.gp.positionNames);d&&i.setTag(s.gp.positionNames,h(d));const m=this.column.getTag(s.gp.positionLabels);return m&&i.setTag(s.gp.positionLabels,h(m)),i}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let i;const r=this;switch(t){case s.Hi.FASTA:i=function(e){return r.joinToFasta(e,r.isHelm())};break;case s.Hi.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);i=function(e){return f(e,n,r.isHelm())};break;case s.Hi.HELM:{const e=r.alphabet===s.YI.DNA||r.alphabet===s.YI.RNA,t=r.getHelmWrappers();i=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return i}getConverter(e,t=void 0){if(e===s.Hi.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${s.Hi.SEPARATOR}'.`);const n=this;if(e===s.Hi.FASTA)return function(e){return n.convertToFasta(e)};if(e===s.Hi.HELM)return function(e){return n.convertToHelm(e)};if(e===s.Hi.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[d.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[d.seqHandler]=new m(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let i=0;i<e.length;++i){const r=e.getOriginal(i);let o=e.getOriginal(i);t&&(o=o.replace(h.EK,"$1")),r===a._S?o=p[s.Hi.FASTA]:r===h.q7?o="":o.length>1&&(o="["+o+"]"),n[i]=o}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){if(this.notation==s.Hi.HELM)return e;const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),i=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let o=t.getOriginal(e);(i||r)&&(o=o.replace(h.EK,"$1"),o=o===h.q7?null:o),n[e]=o||null}return new l.Mu(n.filter((e=>!!e)),p[s.Hi.HELM])}}function f(e,t,n){const i=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let o=e.getOriginal(t);n&&(o=o.replace(h.EK,"$1")),r===a._S?o=p[s.Hi.SEPARATOR]:r===h.q7&&(o=""),i[t]=o}return i.join(t)}function g(e,t,n){const[i,r,o,l]=t,c=new Array(e.length);for(let t=0;t<e.length;++t){const i=e.getCanonical(t);let l=e.getOriginal(t);i===a._S?l=p[s.Hi.HELM]:(n&&(l=l.replace(h.EK,"$1")),l=1===l.length?`${r}${l}${o}`:`${r}[${l}]${o}`),c[t]=l}return`${i}${c.join(".")}${l}`}},8312:(e,t,n)=>{"use strict";n.d(t,{P:()=>r,Q:()=>o});var i=n(6082);const r="substruct-col";async function o(){const e=i.Func.find({package:"Bio",name:"getSeqHelper"});if(0===e.length)throw new Error("Package 'Bio' must be installed for SeqHelper.");return(await e[0].prepare().call()).getOutputParamValue()}},3077:(e,t,n)=>{"use strict";n.d(t,{R:()=>o});var i=n(6082),r=n(826);function o(e){const t=e=>{const t=s.columns.addNewString((e+1).toString());return n.push(t),t},n=[],o=e.length,s=i.DataFrame.create(o),a=r.GO.forColumn(e);for(let e=0;e<o;++e){const i=a.getSplitted(e);for(let r=0;r<i.length;++r){const o=i.getOriginal(r);((n[r]??null)||t(r)).set(e,o,!1)}}return s}},7602:(e,t,n)=>{"use strict";n.d(t,{g:()=>o});var i,r=n(9192);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(i||(i={}));class o{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[i,o]=(0,r.AP)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${i}`,void 0,o),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},4326:(e,t,n)=>{"use strict";n.d(t,{Fo:()=>u,Lp:()=>o,P4:()=>s,fH:()=>r,gp:()=>i,lT:()=>l,mH:()=>a});var i,r,o,s,a,l,c=n(6082);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(e){e.Entropy="Entropy",e.full="100%"}(r||(r={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(o||(o={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(s||(s={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(l||(l={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=16,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=s.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},5540:(e,t,n)=>{"use strict";e=n.hmd(e);var i,r=(i="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,r=void 0!==e?e:{};r.ready=new Promise((function(e,i){t=e,n=i}));var o,s=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),i&&(c=i),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(o=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),r.print||console.log.bind(console);var u,h,d=r.printErr||console.warn.bind(console);Object.assign(r,s),s=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(u=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&x("no native wasm support detected");var p,m,f,g=!1;function y(){var e=h.buffer;r.HEAP8=p=new Int8Array(e),r.HEAP16=new Int16Array(e),r.HEAP32=new Int32Array(e),r.HEAPU8=m=new Uint8Array(e),r.HEAPU16=new Uint16Array(e),r.HEAPU32=f=new Uint32Array(e),r.HEAPF32=new Float32Array(e),r.HEAPF64=new Float64Array(e)}var b=[],v=[],w=[],C=0,A=null,S=null;function x(e){r.onAbort&&r.onAbort(e),d(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var E,_;function M(e){return e.startsWith("data:application/octet-stream;base64,")}function I(e){try{if(e==E&&u)return new Uint8Array(u);if(o)return o(e);throw"both async and sync fetching of the wasm failed"}catch(e){x(e)}}function T(e,t,n){return function(e){return u||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return I(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return I(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){d("failed to asynchronously prepare wasm: "+e),x(e)}))}function L(e){for(;e.length>0;)e.shift()(r)}function N(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,p[this.ptr+12|0]=e},this.get_caught=function(){return 0!=p[this.ptr+12|0]},this.set_rethrown=function(e){e=e?1:0,p[this.ptr+13|0]=e},this.get_rethrown=function(){return 0!=p[this.ptr+13|0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(H(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function $(e){var t=h.buffer;try{return h.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function P(e){return r["_"+e]}M(E="wasmDbscan.wasm")||(_=E,E=r.locateFile?r.locateFile(_,c):c+_);var R="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function O(e,t,n,i,r){var o={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var i=e.charCodeAt(n);i<=127?t++:i<=2047?t+=2:i>=55296&&i<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=B(t);return function(e,t,n){!function(e,t,n,i){if(!(i>0))return 0;for(var r=n+i-1,o=0;o<e.length;++o){var s=e.charCodeAt(o);if(s>=55296&&s<=57343&&(s=65536+((1023&s)<<10)|1023&e.charCodeAt(++o)),s<=127){if(n>=r)break;t[n++]=s}else if(s<=2047){if(n+1>=r)break;t[n++]=192|s>>6,t[n++]=128|63&s}else if(s<=65535){if(n+2>=r)break;t[n++]=224|s>>12,t[n++]=128|s>>6&63,t[n++]=128|63&s}else{if(n+3>=r)break;t[n++]=240|s>>18,t[n++]=128|s>>12&63,t[n++]=128|s>>6&63,t[n++]=128|63&s}}t[n]=0}(e,m,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,i=B(e.length);return t=e,n=i,p.set(t,n),i}},s=P(e),a=[],l=0;if(i)for(var c=0;c<i.length;c++){var u=o[n[c]];u?(0===l&&(l=F()),a[c]=u(i[c])):a[c]=i[c]}var h=s.apply(null,a);return function(e){return 0!==l&&D(l),function(e){return"string"===t?(n=e)?function(e,t,n){for(var i=t+n,r=t;e[r]&&!(r>=i);)++r;if(r-t>16&&e.buffer&&R)return R.decode(e.subarray(t,r));for(var o="";t<r;){var s=e[t++];if(128&s){var a=63&e[t++];if(192!=(224&s)){var l=63&e[t++];if((s=224==(240&s)?(15&s)<<12|a<<6|l:(7&s)<<18|a<<12|l<<6|63&e[t++])<65536)o+=String.fromCharCode(s);else{var c=s-65536;o+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else o+=String.fromCharCode((31&s)<<6|a)}else o+=String.fromCharCode(s)}return o}(m,n,i):"":"boolean"===t?Boolean(e):e;var n,i}(e)}(h)}var k,G={__cxa_throw:function(e,t,n){throw new N(e).init(t,n),e},abort:function(){x("")},emscripten_memcpy_big:function(e,t,n){m.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=m.length,i=2147483648;if((e>>>=0)>i)return!1;for(var r=1;r<=4;r*=2){var o=n*(1+.2/r);if(o=Math.min(o,e+100663296),$(Math.min(i,(t=Math.max(e,o))+(65536-t%65536)%65536)))return!0}return!1}},F=(function(){var e,t,i,o,s={env:G,wasi_snapshot_preview1:G};function a(e,t){var n,i=e.exports;return r.asm=i,h=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,v.unshift(n),function(){if(C--,r.monitorRunDependencies&&r.monitorRunDependencies(C),0==C&&(null!==A&&(clearInterval(A),A=null),S)){var e=S;S=null,e()}}(),i}if(C++,r.monitorRunDependencies&&r.monitorRunDependencies(C),r.instantiateWasm)try{return r.instantiateWasm(s,a)}catch(e){d("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=E,i=s,o=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||M(t)||"function"!=typeof fetch?T(t,i,o):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,i).then(o,(function(e){return d("wasm streaming compile failed: "+e),d("falling back to ArrayBuffer instantiation"),T(t,i,o)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(F=r.asm.stackSave).apply(null,arguments)}),D=function(){return(D=r.asm.stackRestore).apply(null,arguments)},B=function(){return(B=r.asm.stackAlloc).apply(null,arguments)},H=function(){return(H=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function V(){function e(){k||(k=!0,r.calledRun=!0,g||(L(v),t(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)e=r.postRun.shift(),w.unshift(e);var e;L(w)}()))}C>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)e=r.preRun.shift(),b.unshift(e);var e;L(b)}(),C>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),e()}),1)):e()))}if(r.ccall=O,r.cwrap=function(e,t,n,i){var r=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&r&&!i?P(e):function(){return O(e,t,n,arguments)}},S=function e(){k||V(),k||(S=e)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return V(),e.ready});"object"==typeof exports?e.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6295:(e,t,n)=>{"use strict";n.d(t,{$1:()=>a,Hr:()=>S,Ii:()=>m,T6:()=>A,TK:()=>w,a4:()=>d,be:()=>p,gt:()=>y,iS:()=>s,ij:()=>b,lO:()=>h,lP:()=>g,rR:()=>f,tO:()=>l,v_:()=>c,yK:()=>v,zn:()=>u});var i=n(8774),r=n(8498),o=n(6863);r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean,r.aT.Tanimoto,r.aT.Dice,r.aT.Asymmetric,r.aT.BraunBlanquet,r.aT.Cosine,r.aT.Kulczynski,r.aT.McConnaughey,r.aT.RogotGoldberg,r.aT.Russel,r.aT.Sokal,r.aT.Hamming,r.aT.Euclidean;const s=[r.aT.Tanimoto,r.aT.Dice,r.aT.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const i=e.andWithCountBits(t,!0);return i/(n-i)}function l(e,t){return 1-a(e,t)}function c(e,t){return C(a(new i.A(e,32*e.length),new i.A(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function h(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function d(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function p(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function m(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),i=e.andWithCountBits(t,!0);return i/(2*n-3*i)}(e,t)}function f(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:e.andWithCountBits(t,!0)*n/(2*i)}(e,t))}function g(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),i=e.trueCount()*t.trueCount();return 0==i?0:(e.andWithCountBits(t,!0)*n-i)/i}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function b(e,t){return C(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function v(e,t){return C(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function w(e,t){return C(function(e,t){const n=e.andWithCountBits(t,!0),i=e.countBits(!0)+t.countBits(!0),r=e.length,o=r-i+n;return n==r||o==r?1:n/i+o/(2*r-i)}(e,t))}function C(e){return 0===e?3402823e32:1/e-1}function A(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function S(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const i=e.length,r=n.length;let o=0,s=0,a=0;for(;s<i&&a<r;)e[s]===n[a]?(t?.has(e[s])||++o,++s,++a):e[s]<n[a]?++s:++a;return o}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}r.aT.Tanimoto,r.aT.Asymmetric,r.aT.Cosine,r.aT.Sokal,o.Z.HAMMING,o.Z.LEVENSHTEIN,o.Z.MONOMER_CHEMICAL_DISTANCE,o.Z.NEEDLEMANN_WUNSCH},684:(e,t,n)=>{"use strict";n.d(t,{C0:()=>o,GP:()=>i,Gi:()=>a,YP:()=>c,_X:()=>s,n3:()=>r,vb:()=>l});const i="dim-red-preprocessing-function",r="supportedSemTypes",o="supportedTypes",s="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},6863:(e,t,n)=>{"use strict";function i(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,i=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,r=new Float32Array((n.length+i)*(n.length+i));return Object.entries(t).forEach((([e,i])=>{const o=n[i];Object.entries(t).forEach((([t,i])=>{r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=o[i]}))})),(e,t)=>1-r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,i)=>{let r=0;const o=e.length,s=i.length,a=Math.ceil(Math.max(o,s)*(1-n));o!==s&&(r=Math.abs(o-s));let l=0;for(let n=0;n<Math.min(o,s);n++)if(e[n]!==i[n]&&(l+=t(e[n],i[n]),l>a))return 1;return l+=r,l/=Math.max(o,s),l}}n.d(t,{Z:()=>s,V:()=>a});var r=n(2787);const o={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var s;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(s||(s={}));const a={[s.HAMMING]:i,[s.LEVENSHTEIN]:function(){return(e,t)=>(0,r.I)(e,t)/Math.max(e.length,t.length)},[s.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:i,scoringMatrix:r,alphabetIndexes:s}={...o,...e};Object.entries(s).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,o)=>{const s=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-i-(t-1)*i,a[1][t]=0;a[0][0]=0;for(let h=1;h<o.length+1;h++){a[u][0]=-i-(h-1)*i;for(let d=1;d<e.length+1;d++){const p=a[c][d-1]+r[t[e.charCodeAt(d-1)]][t[o.charCodeAt(h-1)]],m=a[c][d]-(s[d]||1===h||h===o.length?i:n),f=a[u][d-1]-(l[d-1]||1===d||d===e.length?i:n);a[u][d]=Math.max(p,f,m),a[u][d]===p?(s[d]=!1,l[d]=!1):a[u][d]===f?(s[d]=!1,l[d]=!0):(s[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.min(e.length,o.length);return(h-a[c][e.length])/h}},[s.MONOMER_CHEMICAL_DISTANCE]:i}},9039:(e,t,n)=>{"use strict";var i;n.d(t,{c:()=>i}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(i||(i={}))},8498:(e,t,n)=>{"use strict";var i,r,o,s,a,l,c;n.d(t,{EG:()=>a,Pn:()=>r,RR:()=>l,Wn:()=>c,aT:()=>o,m6:()=>s,xL:()=>i}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(i||(i={})),function(e){e.Euclidean="Euclidean"}(r||(r={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(o||(o={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(s||(s={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(l||(l={})),function(e){e.CommonItems="Common Items"}(c||(c={}))},2780:(e,t,n)=>{"use strict";n.d(t,{xL:()=>i.xL});var i=n(8498);n(9336)},9336:(e,t,n)=>{"use strict";var i=n(2787),r=n(944),o=n(6295),s=n(3629),a=n(6863),l=n(8498);const c={[l.Pn.Euclidean]:s.ou},u={[l.xL.Levenshtein]:i.I,[l.xL.JaroWinkler]:r.Vb,[l.xL.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let i=1;i<e.length;i++)n+=e[i]==t[i]?0:1;return n/e.length}},[l.xL.Onehot]:function(e,t){return e===t?0:1}},h={[l.aT.Tanimoto]:o.tO,[l.aT.Dice]:o.zn,[l.aT.Asymmetric]:o.gt,[l.aT.BraunBlanquet]:o.ij,[l.aT.Cosine]:o.lO,[l.aT.Kulczynski]:o.rR,[l.aT.McConnaughey]:o.lP,[l.aT.RogotGoldberg]:o.TK,[l.aT.Russel]:o.yK,[l.aT.Sokal]:o.Ii,[l.aT.Hamming]:o.be,[l.aT.Euclidean]:o.a4},d={[l.m6.TanimotoIntArray]:o.v_},p={[l.RR.Difference]:o.T6},m={[l.Wn.CommonItems]:o.Hr},f={[l.EG.Vector]:{[l.Pn.Euclidean]:c[l.Pn.Euclidean]},[l.EG.String]:{[l.xL.Levenshtein]:u[l.xL.Levenshtein],[l.xL.JaroWinkler]:u[l.xL.JaroWinkler],[l.xL.Manhattan]:u[l.xL.Manhattan],[l.xL.Onehot]:u[l.xL.Onehot]},[l.EG.BitArray]:{[l.aT.Tanimoto]:h[l.aT.Tanimoto],[l.aT.Dice]:h[l.aT.Dice],[l.aT.Asymmetric]:h[l.aT.Asymmetric],[l.aT.BraunBlanquet]:h[l.aT.BraunBlanquet],[l.aT.Cosine]:h[l.aT.Cosine],[l.aT.Kulczynski]:h[l.aT.Kulczynski],[l.aT.McConnaughey]:h[l.aT.McConnaughey],[l.aT.RogotGoldberg]:h[l.aT.RogotGoldberg],[l.aT.Russel]:h[l.aT.Russel],[l.aT.Sokal]:h[l.aT.Sokal]},[l.EG.MacroMolecule]:{[a.Z.HAMMING]:a.V[a.Z.HAMMING],[a.Z.LEVENSHTEIN]:a.V[a.Z.LEVENSHTEIN],[a.Z.NEEDLEMANN_WUNSCH]:a.V[a.Z.NEEDLEMANN_WUNSCH],[a.Z.MONOMER_CHEMICAL_DISTANCE]:a.V[a.Z.MONOMER_CHEMICAL_DISTANCE]},[l.EG.Number]:{[l.RR.Difference]:p[l.RR.Difference]},[l.EG.IntArray]:{[l.m6.TanimotoIntArray]:d[l.m6.TanimotoIntArray]},[l.EG.NumberArray]:{[l.Wn.CommonItems]:m[l.Wn.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},8774:(e,t,n)=>{"use strict";n.d(t,{A:()=>i});class i{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,r=i._createBuffer(n);if(t)for(let e=0;e<r.length;e++)r[e]=-1;this._data=r,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,i){if(e<t||e>n)throw new Error(`Argument ${i} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let i=0;i<n;i++)t[i]=e[i]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new i(e._length);n._length=e._length,n._data=i._createBuffer(n._length),n._version=0;const r=e.lengthInInts;for(let i=0;i<r;i++)n._data[i]=e._data[i]&t._data[i];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new i(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new i(e);for(let i=0;i<e;++i)n.setBit(i,t(i));return n._version=0,n}static fromString(e){return i.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new i(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new i(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let r=0,o=0;for(;t-o>=4;)n._data[r++]=255&e[o]|(255&e[o+1])<<8|(255&e[o+2])<<16|(255&e[o+3])<<24,o+=4;return t-o==3&&(n._data[r]=(255&e[o+2])<<16),t-o==2&&(n._data[r]|=(255&e[o+1])<<8),t-o==1&&(n._data[r]|=255&e[o]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new i(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,i=this.lengthInInts;for(let e=0;e<i;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,i=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(i)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,i=!0,r=!0){if(n&&r&&this.setAll(!t,!1),r)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(i)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return i.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let i=e;i<t;++i)n.push(this.getBit(i));return n}setRange(e,t,n,i=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const r=Math.min(e,t),o=Math.max(e,t);if(n)for(let e=r;e<=o;e++)this.setTrue(e);else for(let e=r;e<=o;e++)this.setFalse(e);return this.incrementVersion(i),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const i=this._length;this.setLength(this._length+t);for(let n=i-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let i=e;i<e+t;i++)this.setBit(i,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let i=-1;-1!=(i=e.findNext(i,!t));)this.setFast(n++,this.getBit(i));this._length=n,this._version++}return this}getBit(e){return!!(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=i._onBitCount[255&e];let n=this._data[t];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=i._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let o=0;for(;o<r-1;o++)for(let t=this._data[o]&e._data[o];0!=t;t>>>=8)n+=i._onBitCount[255&t];let s=this._data[o]&e._data[o];const a=31&this._length;for(0!=a&&(s&=~(4294967295<<a));0!=s;s>>>=8)n+=i._onBitCount[255&s];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const r=this.lengthInInts;for(let o=Math.floor(e/32);o<r;o++){let r=t?this._data[o]:~this._data[o];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==r)continue;for(let t=0;0!=r;t+=8,r>>>=8){const n=i._firstOnBit[255&r];if(n>=0)return(e=n+32*o+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let r=Math.floor(e/32);r>=0;r--){let e=t?this._data[r]:~this._data[r];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=i._lastOnBit[e>>>24];if(n>=0)return n+32*r+t}}return-1}}i._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),i._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),i._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},8070:(e,t,n)=>{"use strict";n.d(t,{cb:()=>a,PE:()=>s}),n(4328);var i=n(6082);n(9982),i.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(i.Column.fromList(i.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,o=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function s(e,t,n,i=0,r="timeout"){return o(this,void 0,void 0,(function*(){return new Promise(((o,s)=>{const a=e.subscribe((e=>{try{t(e),o("OK")}catch(e){s(e)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),s(r)}),i);n()}))}))}function a(e){return o(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(r||(r={})),i.DataFrame.fromColumns([i.Column.fromStrings("col",["val1","val2","val3"])])},3629:(e,t,n)=>{"use strict";function i(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function r(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function o(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let i=0;i<e.length;i++)n+=e[i]*t[i];return n}function s(e,t){let n=0;const i=e.length;if(i!==t.length)throw new Error("The dimensionality of the vectors must match");for(let r=0;r<i;++r)n+=Math.pow(e[r]-t[r],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,i=0;for(let r=0;r<t;++r)n+=e[r],i+=Math.pow(e[r],2);const r=n/t,o=1/Math.sqrt(i/t-Math.pow(r,2));for(let n=0;n<t;++n)e[n]=(e[n]-r)*o;return e}n.d(t,{KE:()=>o,S8:()=>a,ou:()=>s,vA:()=>i,wQ:()=>r})},1913:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3282),r=n(9029),o=n(1520),s=n(2586),a=n(8708),l=n(2023),c="errorMessage",u=new i.Name("emUsed"),h={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,p=/\$\{([^}]+)\}/g,m=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:c,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=t;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(e,t){return r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath === ${w}`,i._`${e}.keyword in ${t}`,i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(e,t){const i=[];for(const n in e){const e=t[n];d.test(e)&&i.push([n,x(e)])}return n.object(...i)}function S(e){return d.test(e)?new o._Code(o.safeStringify(e).replace(p,((e,t)=>`" + JSON.stringify(${s.getData(t,b)}) + "`)).replace(m,"")):i.stringify(e)}function x(e){return i._`function(){return ${S(e)}}`}n.if(i._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[o,s]=function(e){let t,n;for(const i in e){if("properties"===i||"items"===i)continue;const r=e[i];if("object"==typeof r){t||(t={});const e=t[i]={};for(const t in r)e[t]=[]}else n||(n={}),n[i]=[]}return[t,n]}(v);s&&function(r){const o=n.const("emErrors",i.stringify(r)),s=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(e=>n.if(C(e,o),(()=>n.code(i._`${o}[${e}.keyword].push(${e})`).assign(i._`${e}.${u}`,!0)))));const{singleError:c}=e;if(c){const e=n.let("message",i._`""`),r=n.let("paramsErrors",i._`[]`);h((t=>{n.if(e,(()=>n.code(i._`${e} += ${"string"==typeof c?c:";"}`))),n.code(i._`${e} += ${d(t)}`),n.assign(r,i._`${r}.concat(${o}[${t}])`)})),a.reportError(t,{message:e,params:i._`{errors: ${r}}`})}else h((e=>a.reportError(t,{message:d(e),params:i._`{errors: ${o}[${e}]}`})));function h(e){n.forIn("key",o,(t=>n.if(i._`${o}[${t}].length`,(()=>e(t)))))}function d(e){return i._`${e} in ${s} ? ${s}[${e}]() : ${y}[${e}]`}}(s),o&&function(e){const r=n.const("emErrors",i.stringify(e)),o=[];for(const t in e)o.push([t,A(e[t],g[t])]);const s=n.const("templates",n.object(...o)),c=n.scopeValue("obj",{ref:h,code:i.stringify(h)}),d=n.let("emPropParams"),p=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(e=>n.if(C(e,r),(()=>{n.assign(d,i._`${c}[${e}.keyword]`),n.assign(p,i._`${r}[${e}.keyword][${e}.params[${d}]]`),n.if(p,(()=>n.code(i._`${p}.push(${e})`).assign(i._`${e}.${u}`,!0)))})))),n.forIn("key",r,(e=>n.forIn("keyProp",i._`${r}[${e}]`,(o=>{n.assign(p,i._`${r}[${e}][${o}]`),n.if(i._`${p}.length`,(()=>{const r=n.const("tmpl",i._`${s}[${e}] && ${s}[${e}][${o}]`);a.reportError(t,{message:i._`${r} ? ${r}() : ${y}[${e}][${o}]`,params:i._`{errors: ${p}}`})}))}))))}(o),function(e){const{props:o,items:s}=e;if(!o&&!s)return;const h=i._`typeof ${f} == "object"`,d=i._`Array.isArray(${f})`,p=n.let("emErrors");let m,b;const v=n.let("templates");function C(e,t){n.assign(p,i.stringify(e)),n.assign(v,A(e,t))}o&&s?(m=n.let("emChildKwd"),n.if(h),n.if(d,(()=>{C(s,g.items),n.assign(m,i.str`items`)}),(()=>{C(o,g.properties),n.assign(m,i.str`properties`)})),b=i._`[${m}]`):s?(n.if(d),C(s,g.items),b=i._`.items`):o&&(n.if(r.and(h,r.not(d))),C(o,g.properties),b=i._`.properties`),n.forOf("err",l.default.vErrors,(e=>function(e,t,o){n.if(r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,i._`${e}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:i._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),s=n.const("emMatches",i._`${r}.exec(${e}.instancePath.slice(${w}.length))`),a=n.const("emChild",i._`${s} && ${s}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(i._`${a} !== undefined && ${a} in ${t}`,(()=>o(a)))}))}(e,p,(t=>n.code(i._`${p}[${t}].push(${e})`).assign(i._`${e}.${u}`,!0))))),n.forIn("key",p,(e=>n.if(i._`${p}[${e}].length`,(()=>{a.reportError(t,{message:i._`${e} in ${v} ? ${v}[${e}]() : ${y}${b}[${e}]`,params:i._`{errors: ${p}[${e}]}`}),n.assign(i._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,i._`${w} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(v))}const o="string"==typeof v?v:v._;o&&function(e){const o=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(function(e){return r.and(i._`${e}.keyword !== ${c}`,i._`!${e}.${u}`,r.or(i._`${e}.instancePath === ${w}`,r.and(i._`${e}.instancePath.indexOf(${w}) === 0`,i._`${e}.instancePath[${w}.length] === "/"`)),i._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,i._`${e}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(i._`${o}.push(${e})`).assign(i._`${e}.${u}`,!0))))),n.if(i._`${o}.length`,(()=>a.reportError(t,{message:S(e),params:i._`{errors: ${o}}`})))}(o),e.keepErrors||function(){const e=n.const("emErrs",i._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(i._`!${t}.${u}`,(()=>n.code(i._`${e}.push(${t})`))))),n.assign(l.default.vErrors,e).assign(l.default.errors,i._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},7433:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv2020=void 0;const i=n(4042),r=n(6105),o=n(6653),s=n(9572),a="https://json-schema.org/draft/2020-12/schema";class l extends i.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(s.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}t.Ajv2020=l,e.exports=t=l,e.exports.Ajv2020=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var c=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var u=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var h=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var d=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},3282:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=t.Ajv=void 0;const i=n(4042),r=n(6144),o=n(6653),s=n(2079),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends i.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(o.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(s,a):s;this.addMetaSchema(e,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}t.Ajv=c,e.exports=t=c,e.exports.Ajv=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var u=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var h=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var d=n(3558);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var p=n(4551);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return p.default}})},1520:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class i extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=i;class r extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof i&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function o(e,...t){const n=[e[0]];let i=0;for(;i<t.length;)l(n,t[i]),n.push(e[++i]);return new r(n)}t._Code=r,t.nil=new r(""),t._=o;const s=new r("+");function a(e,...t){const n=[u(e[0])];let i=0;for(;i<t.length;)n.push(s),l(n,t[i]),n.push(s,u(e[++i]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===s){const n=c(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new r(n)}function l(e,t){var n;t instanceof r?e.push(...t._items):t instanceof i?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function c(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof i||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof i?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=l,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new r(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new r(`.${e}`):o`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new r(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new r(e.toString())}},9029:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const i=n(1520),r=n(7845);var o=n(1520);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return o._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return o.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return o.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return o.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return o.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return o.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return o.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return o.Name}});var s=n(7845);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return s.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return s.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return s.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return s.varKinds}}),t.operators={GT:new i._Code(">"),GTE:new i._Code(">="),LT:new i._Code("<"),LTE:new i._Code("<="),EQ:new i._Code("==="),NEQ:new i._Code("!=="),NOT:new i._Code("!"),OR:new i._Code("||"),AND:new i._Code("&&"),ADD:new i._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class l extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?r.varKinds.var:this.varKind,i=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${i};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof i._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof i.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return L(this.lhs instanceof i.Name?{}:{...this.lhs.names},this.rhs)}}class u extends c{constructor(e,t,n,i){super(e,n,i),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class p extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class m extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof i._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let i=n.length;for(;i--;){const r=n[i];r.optimizeNames(e,t)||($(e,r.names),n.splice(i,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>T(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new b(e):e}return t?!1===e?t instanceof v?t:t.nodes:this.nodes.length?this:new v(P(e),t instanceof v?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return L(e,this.condition),this.else&&T(e,this.else.names),e}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return T(super.names,this.iteration.names)}}class A extends w{constructor(e,t,n,i){super(),this.varKind=e,this.name=t,this.from=n,this.to=i}render(e){const t=e.es5?r.varKinds.var:this.varKind,{name:n,from:i,to:o}=this;return`for(${t} ${n}=${i}; ${n}<${o}; ${n}++)`+super.render(e)}get names(){const e=L(super.names,this.from);return L(e,this.to)}}class S extends w{constructor(e,t,n,i){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=i}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return T(super.names,this.iterable.names)}}class x extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}x.kind="func";class E extends f{render(e){return"return "+super.render(e)}}E.kind="return";class _ extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,i;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(i=this.finally)||void 0===i||i.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&T(e,this.catch.names),this.finally&&T(e,this.finally.names),e}}class M extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}M.kind="catch";class I extends g{render(e){return"finally"+super.render(e)}}function T(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function L(e,t){return t instanceof i._CodeOrName?T(e,t.names):e}function N(e,t,n){return e instanceof i.Name?o(e):(r=e)instanceof i._Code&&r._items.some((e=>e instanceof i.Name&&1===t[e.str]&&void 0!==n[e.str]))?new i._Code(e._items.reduce(((e,t)=>(t instanceof i.Name&&(t=o(t)),t instanceof i._Code?e.push(...t._items):e.push(t),e)),[])):e;var r;function o(e){const i=n[e.str];return void 0===i||1!==t[e.str]?e:(delete t[e.str],i)}}function $(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function P(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:i._`!${G(e)}`}I.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new r.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,i){const r=this._scope.toName(t);return void 0!==n&&i&&(this._constants[r.str]=n),this._leafNode(new l(e,r,n)),r}const(e,t,n){return this._def(r.varKinds.const,e,t,n)}let(e,t,n){return this._def(r.varKinds.let,e,t,n)}var(e,t,n){return this._def(r.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new c(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==i.nil&&this._leafNode(new m(e)),this}object(...e){const t=["{"];for(const[n,r]of e)t.length>1&&t.push(","),t.push(n),(n!==r||this.opts.es5)&&(t.push(":"),(0,i.addCodeArg)(t,r));return t.push("}"),new i._Code(t)}if(e,t,n){if(this._blockNode(new v(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new v(e))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new C(e),t)}forRange(e,t,n,i,o=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const s=this._scope.toName(e);return this._for(new A(o,s,t,n),(()=>i(s)))}forOf(e,t,n,o=r.varKinds.const){const s=this._scope.toName(e);if(this.opts.es5){const e=t instanceof i.Name?t:this.var("_arr",t);return this.forRange("_i",0,i._`${e}.length`,(t=>{this.var(s,i._`${e}[${t}]`),n(s)}))}return this._for(new S("of",o,s,t),(()=>n(s)))}forIn(e,t,n,o=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,i._`Object.keys(${t})`,n);const s=this._scope.toName(e);return this._for(new S("in",o,s,t),(()=>n(s)))}endFor(){return this._endBlockNode(w)}label(e){return this._leafNode(new h(e))}break(e){return this._leafNode(new d(e))}return(e){const t=new E;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const i=new _;if(this._blockNode(i),this.code(e),t){const e=this.name("e");this._currNode=i.catch=new M(e),t(e)}return n&&(this._currNode=i.finally=new I,this.code(n)),this._endBlockNode(M,I)}throw(e){return this._leafNode(new p(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=i.nil,n,r){return this._blockNode(new x(e,t,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=P;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===i.nil?n:n===i.nil?t:i._`${G(t)} ${e} ${G(n)}`}function G(e){return e instanceof i.Name?e:i._`(${e})`}t.or=function(...e){return e.reduce(O)}},7845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const i=n(1520);class r extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var o;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(o||(t.UsedValueState=o={})),t.varKinds={const:new i.Name("const"),let:new i.Name("let"),var:new i.Name("var")};class s{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof i.Name?e:this.name(e)}name(e){return new i.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=s;class a extends i.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=i._`.${new i.Name(t)}[${n}]`}}t.ValueScopeName=a;const l=i._`\n`;t.ValueScope=class extends s{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?l:i.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const i=this.toName(e),{prefix:r}=i,o=null!==(n=t.key)&&void 0!==n?n:t.ref;let s=this._values[r];if(s){const e=s.get(o);if(e)return e}else s=this._values[r]=new Map;s.set(o,i);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=t.ref,i.setValue(t,{property:r,itemIndex:l}),i}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return i._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,s={},a){let l=i.nil;for(const c in e){const u=e[c];if(!u)continue;const h=s[c]=s[c]||new Map;u.forEach((e=>{if(h.has(e))return;h.set(e,o.Started);let s=n(e);if(s){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;l=i._`${l}${n} ${e} = ${s};${this.opts._n}`}else{if(!(s=null==a?void 0:a(e)))throw new r(e);l=i._`${l}${s}${this.opts._n}`}h.set(e,o.Completed)}))}return l}}},8708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const i=n(9029),r=n(4227),o=n(2023);function s(e,t){const n=e.const("err",t);e.if(i._`${o.default.vErrors} === null`,(()=>e.assign(o.default.vErrors,i._`[${n}]`)),i._`${o.default.vErrors}.push(${n})`),e.code(i._`${o.default.errors}++`)}function a(e,t){const{gen:n,validateName:r,schemaEnv:o}=e;o.$async?n.throw(i._`new ${e.ValidationError}(${t})`):(n.assign(i._`${r}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>i.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?i.str`"${e}" keyword must be ${t} ($data)`:i.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,r,o){const{it:l}=e,{gen:u,compositeRule:h,allErrors:d}=l,p=c(e,n,r);(null!=o?o:h||d)?s(u,p):a(l,i._`[${p}]`)},t.reportExtraError=function(e,n=t.keywordError,i){const{it:r}=e,{gen:l,compositeRule:u,allErrors:h}=r;s(l,c(e,n,i)),u||h||a(r,o.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(o.default.errors,t),e.if(i._`${o.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(i._`${o.default.vErrors}.length`,t)),(()=>e.assign(o.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:r,errsCount:s,it:a}){if(void 0===s)throw new Error("ajv implementation error");const l=e.name("err");e.forRange("i",s,o.default.errors,(s=>{e.const(l,i._`${o.default.vErrors}[${s}]`),e.if(i._`${l}.instancePath === undefined`,(()=>e.assign(i._`${l}.instancePath`,(0,i.strConcat)(o.default.instancePath,a.errorPath)))),e.assign(i._`${l}.schemaPath`,i.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(i._`${l}.schema`,n),e.assign(i._`${l}.data`,r))}))};const l={keyword:new i.Name("keyword"),schemaPath:new i.Name("schemaPath"),params:new i.Name("params"),propertyName:new i.Name("propertyName"),message:new i.Name("message"),schema:new i.Name("schema"),parentSchema:new i.Name("parentSchema")};function c(e,t,n){const{createErrors:r}=e.it;return!1===r?i._`{}`:function(e,t,n={}){const{gen:r,it:s}=e,a=[u(s,n),h(e,n)];return function(e,{params:t,message:n},r){const{keyword:s,data:a,schemaValue:c,it:u}=e,{opts:h,propertyName:d,topSchemaRef:p,schemaPath:m}=u;r.push([l.keyword,s],[l.params,"function"==typeof t?t(e):t||i._`{}`]),h.messages&&r.push([l.message,"function"==typeof n?n(e):n]),h.verbose&&r.push([l.schema,c],[l.parentSchema,i._`${p}${m}`],[o.default.data,a]),d&&r.push([l.propertyName,d])}(e,t,a),r.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?i.str`${e}${(0,r.getErrorPath)(t,r.Type.Str)}`:e;return[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,n)]}function h({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:o}){let s=o?t:i.str`${t}/${e}`;return n&&(s=i.str`${s}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,s]}},3835:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const i=n(9029),r=n(3558),o=n(2023),s=n(6939),a=n(4227),l=n(2586);class c{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,s.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=d.call(this,e);if(t)return t;const n=(0,s.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:u}=this.opts,h=new i.CodeGen(this.scope,{es5:a,lines:c,ownProperties:u});let p;e.$async&&(p=h.scopeValue("Error",{ref:r.default,code:i._`require("ajv/dist/runtime/validation_error").default`}));const m=h.scopeName("validate");e.validateName=m;const f={gen:h,allErrors:this.opts.allErrors,data:o.default.data,parentData:o.default.parentData,parentDataProperty:o.default.parentDataProperty,dataNames:[o.default.data],dataPathArr:[i.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:h.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,i.stringify)(e.schema)}:{ref:e.schema}),validateName:m,ValidationError:p,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:i.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:i._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,l.validateFunctionCode)(f),h.optimize(this.opts.code.optimize);const t=h.toString();g=`${h.scopeRefs(o.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${o.default.self}`,`${o.default.scope}`,g)(this,this.scope.get());if(this.scope.value(m,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:m,validateCode:t,scopeValues:h._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof i.Name?void 0:e,items:t instanceof i.Name?void 0:t,dynamicProps:e instanceof i.Name,dynamicItems:t instanceof i.Name},n.source&&(n.source.evaluated=(0,i.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function h(e){return(0,s.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function d(e){for(const i of this._compilations)if(n=e,(t=i).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return i;var t,n}function p(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||m.call(this,e,t)}function m(e,t){const n=this.opts.uriResolver.parse(t),i=(0,s._getFullPath)(this.opts.uriResolver,n);let r=(0,s.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&i===r)return g.call(this,n,e);const o=(0,s.normalizeId)(i),a=this.refs[o]||this.schemas[o];if("string"==typeof a){const t=m.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),o===(0,s.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,i=t[n];return i&&(r=(0,s.resolveUrl)(this.opts.uriResolver,r,i)),new c({schema:t,schemaId:n,root:e,baseId:r})}return g.call(this,n,a)}}t.SchemaEnv=c,t.compileSchema=u,t.resolveRef=function(e,t,n){var i;n=(0,s.resolveUrl)(this.opts.uriResolver,t,n);const r=e.refs[n];if(r)return r;let o=p.call(this,e,n);if(void 0===o){const r=null===(i=e.localRefs)||void 0===i?void 0:i[n],{schemaId:s}=this.opts;r&&(o=new c({schema:r,schemaId:s,root:e,baseId:t}))}return void 0!==o?e.refs[n]=h.call(this,o):void 0},t.getCompilingSchema=d,t.resolveSchema=m;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:i}){var r;if("/"!==(null===(r=e.fragment)||void 0===r?void 0:r[0]))return;for(const i of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(i)];if(void 0===e)return;const r="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(i)&&r&&(t=(0,s.resolveUrl)(this.opts.uriResolver,t,r))}let o;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,s.resolveUrl)(this.opts.uriResolver,t,n.$ref);o=m.call(this,i,e)}const{schemaId:l}=this.opts;return o=o||new c({schema:n,schemaId:l,root:i,baseId:t}),o.schema!==o.root.schema?o:void 0}},2023:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={data:new i.Name("data"),valCxt:new i.Name("valCxt"),instancePath:new i.Name("instancePath"),parentData:new i.Name("parentData"),parentDataProperty:new i.Name("parentDataProperty"),rootData:new i.Name("rootData"),dynamicAnchors:new i.Name("dynamicAnchors"),vErrors:new i.Name("vErrors"),errors:new i.Name("errors"),this:new i.Name("this"),self:new i.Name("self"),scope:new i.Name("scope"),json:new i.Name("json"),jsonPos:new i.Name("jsonPos"),jsonLen:new i.Name("jsonLen"),jsonPart:new i.Name("jsonPart")};t.default=r},4551:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(6939);class r extends Error{constructor(e,t,n,r){super(r||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,i.resolveUrl)(e,t,n),this.missingSchema=(0,i.normalizeId)((0,i.getFullPath)(e,this.missingRef))}}t.default=r},6939:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const i=n(4227),r=n(2017),o=n(7106),s=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!l(e):!!t&&c(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!s.has(n)&&("object"==typeof e[n]&&(0,i.eachItem)(e[n],(e=>t+=c(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=p(t));const i=e.parse(t);return h(e,i)}function h(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=h;const d=/#\/?$/;function p(e){return e?e.replace(d,""):""}t.normalizeId=p,t.resolveUrl=function(e,t,n){return n=p(n),e.resolve(t,n)};const m=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:i}=this.opts,s=p(e[n]||t),a={"":s},l=u(i,s,!1),c={},h=new Set;return o(e,{allKeys:!0},((e,t,i,r)=>{if(void 0===r)return;const o=l+t;let s=a[r];function u(t){const n=this.opts.uriResolver.resolve;if(t=p(s?n(s,t):t),h.has(t))throw f(t);h.add(t);let i=this.refs[t];return"string"==typeof i&&(i=this.refs[i]),"object"==typeof i?d(e,i.schema,t):t!==p(o)&&("#"===t[0]?(d(e,c[t],t),c[t]=e):this.refs[t]=o),t}function g(e){if("string"==typeof e){if(!m.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(s=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=s})),c;function d(e,t,n){if(void 0!==t&&!r(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},396:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},4227:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const i=n(9029),r=n(1520);function o(e,t=e.schema){const{opts:n,self:i}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const r=i.RULES.keywords;for(const n in t)r[n]||m(e,`unknown keyword: "${n}"`)}function s(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function l(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:r}){return(o,s,a,l)=>{const c=void 0===a?s:a instanceof i.Name?(s instanceof i.Name?e(o,s,a):t(o,s,a),a):s instanceof i.Name?(t(o,a,s),s):n(s,a);return l!==i.Name||c instanceof i.Name?c:r(o,c)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",i._`{}`);return void 0!==t&&h(e,n,t),n}function h(e,t,n){Object.keys(n).forEach((n=>e.assign(i._`${t}${(0,i.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(o(e,t),!s(t,e.self.RULES.all))},t.checkUnknownRules=o,t.schemaHasRules=s,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,r,o){if(!o){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return i._`${n}`}return i._`${e}${t}${(0,i.getProperty)(r)}`},t.unescapeFragment=function(e){return l(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=l,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>{e.if(i._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,i._`${n} || {}`).code(i._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,i._`${n} || {}`),h(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:c({mergeNames:(e,t,n)=>e.if(i._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,i._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(i._`${n} !== true`,(()=>e.assign(n,!0===t||i._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=h;const d={};var p;function m(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:d[t.code]||(d[t.code]=new r._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(p||(t.Type=p={})),t.getErrorPath=function(e,t,n){if(e instanceof i.Name){const r=t===p.Num;return n?r?i._`"[" + ${e} + "]"`:i._`"['" + ${e} + "']"`:r?i._`"/" + ${e}`:i._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,i.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=m},7887:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>i(e,t)))}function i(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},i){const r=t.RULES.types[i];return r&&!0!==r&&n(e,r)},t.shouldUseGroup=n,t.shouldUseRule=i},8727:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const i=n(8708),r=n(9029),o=n(2023),s={message:"boolean schema is false"};function a(e,t){const{gen:n,data:r}=e,o={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,i.reportError)(o,s,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:i}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(o.default.data):(t.assign(r._`${i}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:i}=e;!1===i?(n.var(t,!1),a(e)):n.var(t,!0)}},208:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const i=n(396),r=n(7887),o=n(8708),s=n(9029),a=n(4227);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(i.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l||(t.DataType=l={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:i,opts:o}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,o.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,r.schemaHasRulesForType)(e,t[0]));if(c){const r=d(t,i,o.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(e,t,n){const{gen:i,data:r,opts:o}=e,a=i.let("dataType",s._`typeof ${r}`),l=i.let("coerced",s._`undefined`);"array"===o.coerceTypes&&i.if(s._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>i.assign(r,s._`${r}[0]`).assign(a,s._`typeof ${r}`).if(d(t,r,o.strictNumbers),(()=>i.assign(l,r))))),i.if(s._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===o.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void i.elseIf(s._`${a} == "number" || ${a} == "boolean"`).assign(l,s._`"" + ${r}`).elseIf(s._`${r} === null`).assign(l,s._`""`);case"number":return void i.elseIf(s._`${a} == "boolean" || ${r} === null
2
2
  || (${a} == "string" && ${r} && ${r} == +${r})`).assign(l,s._`+${r}`);case"integer":return void i.elseIf(s._`${a} === "boolean" || ${r} === null
3
3
  || (${a} === "string" && ${r} && ${r} == +${r} && !(${r} % 1))`).assign(l,s._`+${r}`);case"boolean":return void i.elseIf(s._`${r} === "false" || ${r} === 0 || ${r} === null`).assign(l,!1).elseIf(s._`${r} === "true" || ${r} === 1`).assign(l,!0);case"null":return i.elseIf(s._`${r} === "" || ${r} === 0 || ${r} === false`),void i.assign(l,null);case"array":i.elseIf(s._`${a} === "string" || ${a} === "number"
4
4
  || ${a} === "boolean" || ${r} === null`).assign(l,s._`[${r}]`)}}i.else(),m(e),i.endIf(),i.if(s._`${l} !== undefined`,(()=>{i.assign(r,l),function({gen:e,parentData:t,parentDataProperty:n},i){e.if(s._`${t} !== undefined`,(()=>e.assign(s._`${t}[${n}]`,i)))}(e,l)}))}(e,t,a):m(e)}))}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,i=l.Correct){const r=i===l.Correct?s.operators.EQ:s.operators.NEQ;let o;switch(e){case"null":return s._`${t} ${r} null`;case"array":o=s._`Array.isArray(${t})`;break;case"object":o=s._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":o=a(s._`!(${t} % 1) && !isNaN(${t})`);break;case"number":o=a();break;default:return s._`typeof ${t} ${r} ${e}`}return i===l.Correct?o:(0,s.not)(o);function a(e=s.nil){return(0,s.and)(s._`typeof ${t} == "number"`,e,n?s._`isFinite(${t})`:s.nil)}}function d(e,t,n,i){if(1===e.length)return h(e[0],t,n,i);let r;const o=(0,a.toHash)(e);if(o.array&&o.object){const e=s._`typeof ${t} != "object"`;r=o.null?e:s._`!${t} || ${e}`,delete o.null,delete o.array,delete o.object}else r=s.nil;o.number&&delete o.integer;for(const e in o)r=(0,s.and)(r,h(e,t,n,i));return r}t.checkDataType=h,t.checkDataTypes=d;const p={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?s._`{type: ${e}}`:s._`{type: ${t}}`};function m(e){const t=function(e){const{gen:t,data:n,schema:i}=e,r=(0,a.schemaRefOrVal)(e,i,"type");return{gen:t,keyword:"type",data:n,schema:i.type,schemaCode:r,schemaValue:r,parentSchema:i,params:{},it:e}}(e);(0,o.reportError)(t,p)}t.reportTypeError=m},7870:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const i=n(9029),r=n(4227);function o(e,t,n){const{gen:o,compositeRule:s,data:a,opts:l}=e;if(void 0===n)return;const c=i._`${a}${(0,i.getProperty)(t)}`;if(s)return void(0,r.checkStrictMode)(e,`default is ignored for: ${c}`);let u=i._`${c} === undefined`;"empty"===l.useDefaults&&(u=i._`${u} || ${c} === null || ${c} === ""`),o.if(u,i._`${c} = ${(0,i.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:i}=e.schema;if("object"===t&&n)for(const t in n)o(e,t,n[t].default);else"array"===t&&Array.isArray(i)&&i.forEach(((t,n)=>o(e,n,t.default)))}},2586:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const i=n(8727),r=n(208),o=n(7887),s=n(208),a=n(7870),l=n(3673),c=n(4495),u=n(9029),h=n(2023),d=n(6939),p=n(4227),m=n(8708);function f({gen:e,validateName:t,schema:n,schemaEnv:i,opts:r},o){r.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,i.$async,(()=>{e.code(u._`"use strict"; ${g(n,r)}`),function(e,t){e.if(h.default.valCxt,(()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)}),(()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)}))}(e,r),e.code(o)})):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(r)}`,i.$async,(()=>e.code(g(n,r)).code(o)))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,p.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:i,self:r}=e;t.$ref&&i.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(t,r.RULES)&&r.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return A(e,[],!1,t);const n=(0,r.getSchemaTypes)(e.schema);A(e,n,!(0,r.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:i,opts:r}){const o=n.$comment;if(!0===r.$comment)e.code(u._`${h.default.self}.logger.log(${o})`);else if("function"==typeof r.$comment){const n=u.str`${i}/$comment`,r=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${o}, ${n}, ${r}.schema)`)}}function A(e,t,n,i){const{gen:r,schema:a,data:l,allErrors:c,opts:d,self:m}=e,{RULES:f}=m;function g(p){(0,o.shouldUseGroup)(a,p)&&(p.type?(r.if((0,s.checkDataType)(p.type,l,d.strictNumbers)),S(e,p),1===t.length&&t[0]===p.type&&n&&(r.else(),(0,s.reportTypeError)(e)),r.endIf()):S(e,p),c||r.if(u._`${h.default.errors} === ${i||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,p.schemaHasRulesButRef)(a,f)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{x(e.dataTypes,t)||E(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const i of e.dataTypes)x(t,i)?n.push(i):t.includes("integer")&&"number"===i&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&E(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const i in n){const r=n[i];if("object"==typeof r&&(0,o.shouldUseRule)(e.schema,r)){const{type:n}=r.definition;n.length&&!n.some((e=>{return i=e,(n=t).includes(i)||"number"===i&&n.includes("integer");var n,i}))&&E(e,`missing type "${n.join(",")}" for keyword "${i}"`)}}}(e,e.dataTypes))}(e,t),r.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):r.block((()=>M(e,"$ref",f.all.$ref.definition)))}function S(e,t){const{gen:n,schema:i,opts:{useDefaults:r}}=e;r&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,o.shouldUseRule)(i,n)&&M(e,n.keyword,n.definition,t.type)}))}function x(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function E(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,p.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:i}=e;f(e,(()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,p.checkStrictMode)(e,"default is ignored in the schema root")}(e),i.let(h.default.vErrors,null),i.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:i,ValidationError:r,opts:o}=e;n.$async?t.if(u._`${h.default.errors} === 0`,(()=>t.return(h.default.data)),(()=>t.throw(u._`new ${r}(${h.default.vErrors})`))):(t.assign(u._`${i}.errors`,h.default.vErrors),o.unevaluated&&function({gen:e,evaluated:t,props:n,items:i}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),i instanceof u.Name&&e.assign(u._`${t}.items`,i)}(e),t.return(u._`${h.default.errors} === 0`))}(e)}))}(e):f(e,(()=>(0,i.topBoolOrEmptySchema)(e)))};class _{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,p.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",L(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",h.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?m.reportExtraError:m.reportError)(this,this.def.error,t)}$dataError(){(0,m.reportError)(this,this.def.$dataError||m.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,m.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:i,schemaType:r,def:o}=this;n.if((0,u.or)(u._`${i} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(r.length||o.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:i,it:r}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,s.checkDataTypes)(e,t,r.opts.strictNumbers,s.DataType.Wrong)}`}return u.nil}(),function(){if(i.validateSchema){const n=e.scopeValue("validate$data",{ref:i.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,c.getSubschema)(this.it,e);(0,c.extendSubschemaData)(n,this.it,e),(0,c.extendSubschemaMode)(n,e);const r={...this.it,...n,items:void 0,props:void 0};return function(e,t){b(e)&&(v(e),y(e))?function(e,t){const{schema:n,gen:i,opts:r}=e;r.$comment&&n.$comment&&C(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,d.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const o=i.const("_errs",h.default.errors);w(e,o),i.var(t,u._`${o} === ${h.default.errors}`)}(e,t):(0,i.boolOrEmptySchema)(e,t)}(r,t),r}mergeEvaluated(e,t){const{it:n,gen:i}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=p.mergeEvaluated.props(i,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=p.mergeEvaluated.items(i,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:i}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return i.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function M(e,t,n,i){const r=new _(e,n,t);"code"in n?n.code(r,i):r.$data&&n.validate?(0,l.funcKeywordCode)(r,n):"macro"in n?(0,l.macroKeywordCode)(r,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(r,n)}t.KeywordCxt=_;const I=/^\/(?:[^~]|~0|~1)*$/,T=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function L(e,{dataLevel:t,dataNames:n,dataPathArr:i}){let r,o;if(""===e)return h.default.rootData;if("/"===e[0]){if(!I.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);r=e,o=h.default.rootData}else{const s=T.exec(e);if(!s)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+s[1];if(r=s[2],"#"===r){if(a>=t)throw new Error(l("property/index",a));return i[t-a]}if(a>t)throw new Error(l("data",a));if(o=n[t-a],!r)return o}let s=o;const a=r.split("/");for(const e of a)e&&(o=u._`${o}${(0,u.getProperty)((0,p.unescapeJsonPointer)(e))}`,s=u._`${s} && ${o}`);return s;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=L},3673:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const i=n(9029),r=n(2023),o=n(5765),s=n(8708);function a(e){const{gen:t,data:n,it:r}=e;t.if(r.parentData,(()=>t.assign(n,i._`${r.parentData}[${r.parentDataProperty}]`)))}function l(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,i.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:r,schema:o,parentSchema:s,it:a}=e,c=t.macro.call(a.self,o,s,a),u=l(n,r,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const h=n.name("valid");e.subschema({schema:c,schemaPath:i.nil,errSchemaPath:`${a.errSchemaPath}/${r}`,topSchemaRef:u,compositeRule:!0},h),e.pass(h,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:c,keyword:u,schema:h,parentSchema:d,$data:p,it:m}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(m,t);const f=!p&&t.compile?t.compile.call(m.self,h,d,m):t.validate,g=l(c,u,f),y=c.let("valid");function b(n=(t.async?i._`await `:i.nil)){const s=m.opts.passContext?r.default.this:r.default.self,a=!("compile"in t&&!p||!1===t.schema);c.assign(y,i._`${n}${(0,o.callValidateCode)(e,g,s,a)}`,t.modifying)}function v(e){var n;c.if((0,i.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)b(),t.modifying&&a(e),v((()=>e.error()));else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try((()=>b(i._`await `)),(t=>c.assign(y,!1).if(i._`${t} instanceof ${m.ValidationError}`,(()=>c.assign(e,i._`${t}.errors`)),(()=>c.throw(t))))),e}():function(){const e=i._`${g}.errors`;return c.assign(e,null),b(i.nil),e}();t.modifying&&a(e),v((()=>function(e,t){const{gen:n}=e;n.if(i._`Array.isArray(${t})`,(()=>{n.assign(r.default.vErrors,i._`${r.default.vErrors} === null ? ${t} : ${r.default.vErrors}.concat(${t})`).assign(r.default.errors,i._`${r.default.vErrors}.length`),(0,s.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:i},r,o){if(Array.isArray(r.keyword)?!r.keyword.includes(o):r.keyword!==o)throw new Error("ajv implementation error");const s=r.dependencies;if(null==s?void 0:s.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${o}: ${s.join(",")}`);if(r.validateSchema&&!r.validateSchema(e[o])){const e=`keyword "${o}" value is invalid at path "${i}": `+n.errorsText(r.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},4495:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const i=n(9029),r=n(4227);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:o,schemaPath:s,errSchemaPath:a,topSchemaRef:l}){if(void 0!==t&&void 0!==o)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const o=e.schema[t];return void 0===n?{schema:o,schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:o[n],schemaPath:i._`${e.schemaPath}${(0,i.getProperty)(t)}${(0,i.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,r.escapeFragment)(n)}`}}if(void 0!==o){if(void 0===s||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:o,schemaPath:s,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:o,data:s,dataTypes:a,propertyName:l}){if(void 0!==s&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=t;if(void 0!==n){const{errorPath:s,dataPathArr:a,opts:l}=t;u(c.let("data",i._`${t.data}${(0,i.getProperty)(n)}`,!0)),e.errorPath=i.str`${s}${(0,r.getErrorPath)(n,o,l.jsPropertySyntax)}`,e.parentDataProperty=i._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==s&&(u(s instanceof i.Name?s:c.let("data",s,!0)),void 0!==l&&(e.propertyName=l)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:i,createErrors:r,allErrors:o}){void 0!==i&&(e.compositeRule=i),void 0!==r&&(e.createErrors=r),void 0!==o&&(e.allErrors=o),e.jtdDiscriminator=t,e.jtdMetadata=n}},4042:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var i=n(2586);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return i.KeywordCxt}});var r=n(9029);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return r.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return r.CodeGen}});const o=n(3558),s=n(4551),a=n(396),l=n(3835),c=n(9029),u=n(6939),h=n(208),d=n(4227),p=n(3837),m=n(5944),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'};function w(e){var t,n,i,r,o,s,a,l,c,u,h,d,p,g,y,b,v,w,C,A,S,x,E,_,M;const I=e.strict,T=null===(t=e.code)||void 0===t?void 0:t.optimize,L=!0===T||void 0===T?1:T||0,N=null!==(i=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==i?i:f,$=null!==(r=e.uriResolver)&&void 0!==r?r:m.default;return{strictSchema:null===(s=null!==(o=e.strictSchema)&&void 0!==o?o:I)||void 0===s||s,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:I)||void 0===l||l,strictTypes:null!==(u=null!==(c=e.strictTypes)&&void 0!==c?c:I)&&void 0!==u?u:"log",strictTuples:null!==(d=null!==(h=e.strictTuples)&&void 0!==h?h:I)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(p=e.strictRequired)&&void 0!==p?p:I)&&void 0!==g&&g,code:e.code?{...e.code,optimize:L,regExp:N}:{optimize:L,regExp:N},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:200,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:200,meta:null===(v=e.meta)||void 0===v||v,messages:null===(w=e.messages)||void 0===w||w,inlineRefs:null===(C=e.inlineRefs)||void 0===C||C,schemaId:null!==(A=e.schemaId)&&void 0!==A?A:"$id",addUsedSchema:null===(S=e.addUsedSchema)||void 0===S||S,validateSchema:null===(x=e.validateSchema)||void 0===x||x,validateFormats:null===(E=e.validateFormats)||void 0===E||E,unicodeRegExp:null===(_=e.unicodeRegExp)||void 0===_||_,int32range:null===(M=e.int32range)||void 0===M||M,uriResolver:$}}class C{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...w(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return I;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const i=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,e,"NOT SUPPORTED"),A.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=M.call(this),e.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),x.call(this),e.validateFormats=i}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let i=p;"id"===n&&(i={...p},i.id=i.$id,delete i.$id),t&&e&&this.addMetaSchema(i,i[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const i=n(t);return"$async"in n||(this.errors=n.errors),i}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return i.call(this,e,t);async function i(e,t){await r.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||o.call(this,n)}async function r(e){e&&!this.getSchema(e)&&await i.call(this,{$ref:e},!0)}async function o(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof s.default))throw t;return a.call(this,t),await l.call(this,t.missingSchema),o.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function l(e){const n=await c.call(this,e);this.refs[e]||await r.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function c(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,i=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,i);return this}let r;if("object"==typeof e){const{schemaId:t}=this.opts;if(r=e[t],void 0!==r&&"string"!=typeof r)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||r),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,i,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const i=this.validate(n,e);if(!i&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return i}getSchema(e){let t;for(;"string"==typeof(t=S.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,i=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,i,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=S.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(L.call(this,n,t),!t)return(0,d.eachItem)(n,(e=>N.call(this,e))),this;P.call(this,t);const i={...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)};return(0,d.eachItem)(n,0===i.type.length?e=>N.call(this,e,i):e=>i.type.forEach((t=>N.call(this,e,i,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const i of t){const t=i.split("/").slice(1);let r=e;for(const e of t)r=r[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:i}=t.definition,o=r[e];i&&o&&(r[e]=O(o))}}return e}_removeAllSchemas(e,t){for(const n in e){const i=e[n];t&&!t.test(n)||("string"==typeof i?delete e[n]:i&&!i.meta&&(this._cache.delete(i.schema),delete e[n]))}}_addSchema(e,t,n,i=this.opts.validateSchema,r=this.opts.addUsedSchema){let o;const{schemaId:s}=this.opts;if("object"==typeof e)o=e[s];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(o||n);const c=u.getSchemaRefs.call(this,e,n);return a=new l.SchemaEnv({schema:e,schemaId:s,meta:t,baseId:n,localRefs:c}),this._cache.set(a.schema,a),r&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),i&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function A(e,t,n,i="error"){for(const r in e){const o=r;o in t&&this.logger[i](`${n}: option ${r}. ${e[o]}`)}}function S(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function x(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function E(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function _(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function M(){const e={...this.opts};for(const t of g)delete e[t];return e}C.ValidationError=o.default,C.MissingRefError=s.default,t.default=C;const I={log(){},warn(){},error(){}},T=/^[a-z_$][a-z0-9_$:-]*$/i;function L(e,t){const{RULES:n}=this;if((0,d.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!T.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function N(e,t,n){var i;const r=null==t?void 0:t.post;if(n&&r)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:o}=this;let s=r?o.post:o.rules.find((({type:e})=>e===n));if(s||(s={type:n,rules:[]},o.rules.push(s)),o.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)}};t.before?$.call(this,s,a,t.before):s.rules.push(a),o.all[e]=a,null===(i=t.implements)||void 0===i||i.forEach((e=>this.addKeyword(e)))}function $(e,t,n){const i=e.rules.findIndex((e=>e.keyword===n));i>=0?e.rules.splice(i,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function P(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=O(t)),e.validateSchema=this.compile(t,!0))}const R={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function O(e){return{anyOf:[e,R]}}},9572:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1678),r=n(7216),o=n(9547),s=n(8226),a=n(518),l=n(4588),c=n(5707),u=n(7082),h=["/properties"];t.default=function(e){return[i,r,o,s,a,t(this,l),c,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,h):n}}},6250:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2017);i.code='require("ajv/dist/runtime/equal").default',t.default=i},3853:(e,t)=>{"use strict";function n(e){const t=e.length;let n,i=0,r=0;for(;r<t;)i++,n=e.charCodeAt(r++),n>=55296&&n<=56319&&r<t&&(n=e.charCodeAt(r),56320==(64512&n)&&r++);return i}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},5944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(8343);i.code='require("ajv/dist/runtime/uri").default',t.default=i},3558:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},5457:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const i=n(9029),r=n(4227),o={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:i}=t;Array.isArray(i)?s(e,i):(0,r.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function s(e,t){const{gen:n,schema:o,data:s,keyword:a,it:l}=e;l.items=!0;const c=n.const("len",i._`${s}.length`);if(!1===o)e.setParams({len:t.length}),e.pass(i._`${c} <= ${t.length}`);else if("object"==typeof o&&!(0,r.alwaysValidSchema)(l,o)){const o=n.var("valid",i._`${c} <= ${t.length}`);n.if((0,i.not)(o),(()=>function(o){n.forRange("i",t.length,c,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:r.Type.Num},o),l.allErrors||n.if((0,i.not)(o),(()=>n.break()))}))}(o))),e.ok(o)}}t.validateAdditionalItems=s,t.default=o},8660:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(2023),s=n(4227),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>r._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:l,errsCount:c,it:u}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:h,opts:d}=u;if(u.props=!0,"all"!==d.removeAdditional&&(0,s.alwaysValidSchema)(u,n))return;const p=(0,i.allSchemaProperties)(a.properties),m=(0,i.allSchemaProperties)(a.patternProperties);function f(e){t.code(r._`delete ${l}[${e}]`)}function g(i){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)f(i);else{if(!1===n)return e.setParams({additionalProperty:i}),e.error(),void(h||t.break());if("object"==typeof n&&!(0,s.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===d.removeAdditional?(y(i,n,!1),t.if((0,r.not)(n),(()=>{e.reset(),f(i)}))):(y(i,n),h||t.if((0,r.not)(n),(()=>t.break())))}}}function y(t,n,i){const r={keyword:"additionalProperties",dataProp:t,dataPropType:s.Type.Str};!1===i&&Object.assign(r,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(r,n)}t.forIn("key",l,(n=>{p.length||m.length?t.if(function(n){let o;if(p.length>8){const e=(0,s.schemaRefOrVal)(u,a.properties,"properties");o=(0,i.isOwnProperty)(t,e,n)}else o=p.length?(0,r.or)(...p.map((e=>r._`${n} === ${e}`))):r.nil;return m.length&&(o=(0,r.or)(o,...m.map((t=>r._`${(0,i.usePattern)(e,t)}.test(${n})`)))),(0,r.not)(o)}(n),(()=>g(n))):g(n)})),e.ok(r._`${c} === ${o.default.errors}`)}};t.default=a},5844:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:r}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const o=t.name("valid");n.forEach(((t,n)=>{if((0,i.alwaysValidSchema)(r,t))return;const s=e.subschema({keyword:"allOf",schemaProp:n},o);e.ok(o),e.mergeEvaluated(s)}))}};t.default=r},6505:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(5765).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=i},2661:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?i.str`must contain at least ${e} valid item(s)`:i.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?i._`{minContains: ${e}}`:i._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:o,data:s,it:a}=e;let l,c;const{minContains:u,maxContains:h}=o;a.opts.next?(l=void 0===u?1:u,c=h):l=1;const d=t.const("len",i._`${s}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,r.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,r.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,r.alwaysValidSchema)(a,n)){let t=i._`${d} >= ${l}`;return void 0!==c&&(t=i._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const p=t.name("valid");function m(){const e=t.name("_valid"),n=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(i._`${e}++`),void 0===c?t.if(i._`${e} >= ${l}`,(()=>t.assign(p,!0).break())):(t.if(i._`${e} > ${c}`,(()=>t.assign(p,!1).break())),1===l?t.assign(p,!0):t.if(i._`${e} >= ${l}`,(()=>t.assign(p,!0))))}(n)))))}function f(n,i){t.forRange("i",0,d,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:r.Type.Num,compositeRule:!0},n),i()}))}void 0===c&&1===l?f(p,(()=>t.if(p,(()=>t.break())))):0===l?(t.let(p,!0),void 0!==c&&t.if(i._`${s}.length > 0`,m)):(t.let(p,!1),m()),e.result(p,(()=>e.reset()))}};t.default=o},3025:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const i=n(9029),r=n(4227),o=n(5765);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const r=1===t?"property":"properties";return i.str`must have ${r} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:r}})=>i._`{property: ${e},
5
5
  missingProperty: ${r},
6
6
  depsCount: ${t},
7
- deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const i in e)"__proto__"!==i&&((Array.isArray(e[i])?t:n)[i]=e[i]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:r,it:s}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,o.propertyInData)(n,r,l,s.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(u,(()=>{for(const t of c)(0,o.checkReportMissingProp)(e,t)})):(n.if(i._`${u} && (${(0,o.checkMissingProp)(e,c,a)})`),(0,o.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:i,keyword:s,it:a}=e,l=n.name("valid");for(const c in t)(0,r.alwaysValidSchema)(a,t[c])||(n.if((0,o.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:s,schemaProp:c},l);e.mergeValidEvaluated(t,l)}),(()=>n.var(l,!0))),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=s},4845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,i.validateSchemaDeps)(e)};t.default=r},1239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>i.str`must match "${e.ifClause}" schema`,params:({params:e})=>i._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:o}=e;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(o,'"if" without "then" and "else" is ignored');const a=s(o,"then"),l=s(o,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,i.not)(u),h("else"));function h(n,r){return()=>{const o=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(o,c),r?t.assign(r,i._`${n}`):e.setParams({ifClause:n})}}e.pass(c,(()=>e.error(!0)))}};function s(e,t){const n=e.schema[t];return void 0!==n&&!(0,r.alwaysValidSchema)(e,n)}t.default=o},6378:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5457),r=n(5354),o=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(9713),u=n(8660),h=n(117),d=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),b=n(4426);t.default=function(e=!1){const t=[p.default,m.default,f.default,g.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(r.default,s.default):t.push(i.default,o.default),t.push(a.default),t}},494:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const i=n(9029),r=n(4227),o=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,r.alwaysValidSchema)(n,t)||e.ok((0,o.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:o,parentSchema:s,data:a,keyword:l,it:c}=e;!function(e){const{opts:i,errSchemaPath:o}=c,s=n.length,a=s===e.minItems&&(s===e.maxItems||!1===e[t]);if(i.strictTuples&&!a){const e=`"${l}" is ${s}-tuple, but minItems or maxItems/${t} are not specified or different at path "${o}"`;(0,r.checkStrictMode)(c,e,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(o,n.length,c.items));const u=o.name("valid"),h=o.const("len",i._`${a}.length`);n.forEach(((t,n)=>{(0,r.alwaysValidSchema)(c,t)||(o.if(i._`${h} > ${n}`,(()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=s},3966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:i}=e,{prefixItems:a}=n;i.items=!0,(0,r.alwaysValidSchema)(i,t)||(a?(0,s.validateAdditionalItems)(e,a):e.ok((0,o.validateArray)(e)))}};t.default=a},7923:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:r}=e;if((0,i.alwaysValidSchema)(r,n))return void e.fail();const o=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},o),e.failResult(o,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=r},6163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>i._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:o,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&o.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block((function(){a.forEach(((n,o)=>{let a;(0,r.alwaysValidSchema)(s,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:o,compositeRule:!0},u),o>0&&t.if(i._`${u} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${o}]`).else(),t.if(u,(()=>{t.assign(l,!0),t.assign(c,o),a&&e.mergeEvaluated(a,i.Name)}))}))})),e.result(l,(()=>e.reset()),(()=>e.error(!0)))}};t.default=o},5333:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,i.allSchemaProperties)(n),d=h.filter((e=>(0,o.alwaysValidSchema)(c,n[e])));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const p=u.strictSchema&&!u.allowMatchingProperties&&l.properties,m=t.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,s.evaluatedPropsToName)(t,c.props));const{props:f}=c;function g(e){for(const t in p)new RegExp(e).test(t)&&(0,o.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(o=>{t.if(r._`${(0,i.usePattern)(e,n)}.test(${o})`,(()=>{const i=d.includes(n);i||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:o,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==f?t.assign(r._`${f}[${o}]`,!0):i||c.allErrors||t.if((0,r.not)(m),(()=>t.break()))}))}))}!function(){for(const e of h)p&&g(e),c.allErrors?y(e):(t.var(m,!0),y(e),t.if(m))}()}};t.default=a},5354:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(494),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,i.validateTuple)(e,"items")};t.default=r},117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),r=n(5765),o=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,r.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=o.mergeEvaluated.props(t,(0,o.toHash)(u),c.props));const h=u.filter((e=>!(0,o.alwaysValidSchema)(c,n[e])));if(0===h.length)return;const d=t.name("valid");for(const n of h)p(n)?m(n):(t.if((0,r.propertyInData)(t,l,n,c.opts.ownProperties)),m(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function p(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},9713:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>i._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:o,it:s}=e;if((0,r.alwaysValidSchema)(s,n))return;const a=t.name("valid");t.forIn("key",o,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,i.not)(a),(()=>{e.error(!0),s.allErrors||t.break()}))})),e.ok(a)}};t.default=o},4426:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,i.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=r},5765:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const i=n(9029),r=n(4227),o=n(2023),s=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return i._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,r){const o=i._`${t}${(0,i.getProperty)(n)} === undefined`;return r?(0,i.or)(o,(0,i.not)(l(e,t,n))):o}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:r,it:o}=e;n.if(c(n,r,t,o.opts.ownProperties),(()=>{e.setParams({missingProperty:i._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},r,o){return(0,i.or)(...r.map((r=>(0,i.and)(c(e,t,r,n.ownProperties),i._`${o} = ${r}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,r){const o=i._`${t}${(0,i.getProperty)(n)} !== undefined`;return r?i._`${o} && ${l(e,t,n)}`:o},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,r.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:r,schemaPath:s,errorPath:a},it:l},c,u,h){const d=h?i._`${e}, ${t}, ${r}${s}`:t,p=[[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,a)],[o.default.parentData,l.parentData],[o.default.parentDataProperty,l.parentDataProperty],[o.default.rootData,o.default.rootData]];l.opts.dynamicRef&&p.push([o.default.dynamicAnchors,o.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return u!==i.nil?i._`${c}.call(${u}, ${m})`:i._`${c}(${m})`};const h=i._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const r=t.unicodeRegExp?"u":"",{regExp:o}=t.code,a=o(n,r);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===o.code?h:(0,s.useFunc)(e,o)}(${n}, ${r})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:o,it:s}=e,a=t.name("valid");if(s.allErrors){const e=t.let("valid",!0);return l((()=>t.assign(e,!1))),e}return t.var(a,!0),l((()=>t.break())),a;function l(s){const l=t.const("len",i._`${n}.length`);t.forRange("i",0,l,(n=>{e.subschema({keyword:o,dataProp:n,dataPropType:r.Type.Num},a),t.if((0,i.not)(a),s)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:o,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,r.alwaysValidSchema)(s,e)))&&!s.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block((()=>n.forEach(((n,r)=>{const s=e.subschema({keyword:o,schemaProp:r,compositeRule:!0},l);t.assign(a,i._`${a} || ${l}`),e.mergeValidEvaluated(s,l)||t.if((0,i.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},3463:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3463),r=n(3693),o=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,r.default];t.default=o},3693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const i=n(4551),r=n(5765),o=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:r}=e,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=r,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:m});return h(e,o._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,s,n);if(void 0===f)throw new i.default(r.opts.uriResolver,s,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(f):function(i){const r=t.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,o.stringify)(i)}:{ref:i}),s=t.name("valid"),a=e.subschema({schema:i,dataTypes:[],schemaPath:o.nil,topSchemaRef:r,errSchemaPath:n},s);e.mergeEvaluated(a),e.ok(s)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):o._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,i){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,p=d.passContext?s.default.this:o.nil;function m(e){const t=o._`${e}.errors`;a.assign(s.default.vErrors,o._`${s.default.vErrors} === null ? ${t} : ${s.default.vErrors}.concat(${t})`),a.assign(s.default.errors,o._`${s.default.vErrors}.length`)}function f(e){var t;if(!c.opts.unevaluated)return;const i=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const t=a.var("props",o._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,o.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const t=a.var("items",o._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,o.Name)}}i?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(o._`await ${(0,r.callValidateCode)(e,t,p)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(o._`!(${e} instanceof ${c.ValidationError})`,(()=>a.throw(e))),m(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,r.callValidateCode)(e,t,p),(()=>f(t)),(()=>m(t)))}t.getValidate=u,t.callRef=h,t.default=c},6653:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(7652),o=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===r.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>i._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:l,parentSchema:c,it:u}=e,{oneOf:h}=c;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!h)throw new Error("discriminator: requires oneOf keyword");const p=t.let("valid",!1),m=t.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function f(n){const r=t.name("valid"),o=e.subschema({keyword:"oneOf",schemaProp:n},r);return e.mergeEvaluated(o,i.Name),r}t.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=r(c);let i=!0;for(let t=0;t<h.length;t++){let c=h[t];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,u.self.RULES)){const e=c.$ref;if(c=o.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),c instanceof o.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(u.opts.uriResolver,u.baseId,e)}const p=null===(e=null==c?void 0:c.properties)||void 0===e?void 0:e[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||r(c)),l(p,t)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return t;function r({required:e}){return Array.isArray(e)&&e.includes(d)}function l(e,t){if(e.const)p(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of e.enum)p(n,t)}}function p(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${d}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(i._`${m} === ${e}`),t.assign(p,f(n[e]));t.else(),e.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:d}),t.endIf()}()),(()=>e.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:d}))),e.ok(p)}};t.default=l},7652:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),u=n(9857),h=[s.default,i.default,r.default,(0,o.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},6144:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(7532),a=n(9857),l=[i.default,r.default,(0,o.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},2476:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const i=n(9029),r=n(2023),o=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=i._`${r.default.dynamicAnchors}${(0,i.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:i}=e.it,{root:r,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=i.opts,h=new o.SchemaEnv({schema:n,schemaId:u,root:r,baseId:a,localRefs:l,meta:c});return o.compileSchema.call(i,h),(0,s.getValidate)(e,h)}(e);n.if(i._`!${l}`,(()=>n.assign(l,c)))}t.dynamicAnchor=l,t.default=a},3252:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const i=n(9029),r=n(2023),o=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:s,it:a}=e;if("#"!==t[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",i._`${r.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,i){return i?()=>n.block((()=>{(0,o.callRef)(e,t),n.let(i,!0)})):()=>(0,o.callRef)(e,t)}}t.dynamicRef=a,t.default=s},5520:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),r=n(3252),o=n(2721),s=n(3799),a=[i.default,r.default,o.default,s.default];t.default=a},2721:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),r=n(4227),o={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,i.dynamicAnchor)(e,""):(0,r.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=o},3799:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3252),r={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,i.dynamicRef)(e,e.schema)};t.default=r},4737:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match format "${e}"`,params:({schemaCode:e})=>i._`{format: ${e}}`},code(e,t){const{gen:n,data:r,$data:o,schema:s,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(o?function(){const o=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${o}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(u,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(u,s))),e.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${u}`,function(){const e=h.$async?i._`(${s}.async ? await ${u}(${r}) : ${u}(${r}))`:i._`${u}(${r})`,n=i._`(typeof ${u} == "function" ? ${e} : ${u}.test(${r}))`;return i._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const o=d.formats[s];if(!o)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${s}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===o)return;const[a,l,p]=function(e){const t=e instanceof RegExp?(0,i.regexpCode)(e):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,r=n.scopeValue("formats",{key:s,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,r]:[e.type||"string",e.validate,i._`${r}.validate`]}(o);a===t&&e.pass(function(){if("object"==typeof o&&!(o instanceof RegExp)&&o.async){if(!h.$async)throw new Error("async format in sync schema");return i._`await ${p}(${r})`}return"function"==typeof l?i._`${p}(${r})`:i._`${p}.test(${r})`}())}())}};t.default=r},7532:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=[n(4737).default];t.default=i},9857:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1846),r=n(4845),o=n(2626),s=[i.default,r.default,o.default];t.default=s},3265:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(392),r=n(3445),o=[i.default,r.default];t.default=o},3445:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:o,it:s}=e,a=s.items||0;if(!0===a)return;const l=t.const("len",i._`${o}.length`);if(!1===n)e.setParams({len:a}),e.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(s,n)){const n=t.var("valid",i._`${l} <= ${a}`);t.if((0,i.not)(n),(()=>function(n,o){t.forRange("i",o,l,(o=>{e.subschema({keyword:"unevaluatedItems",dataProp:o,dataPropType:r.Type.Num},n),s.allErrors||t.if((0,i.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}s.items=!0}};t.default=o},392:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>i._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:s,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(o){if(!1===n)return e.setParams({unevaluatedProperty:o}),e.error(),void(c||t.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:o,dataPropType:r.Type.Str},n),c||t.if((0,i.not)(n),(()=>t.break()))}}u instanceof i.Name?t.if(i._`${u} !== true`,(()=>t.forIn("key",s,(e=>t.if(function(e,t){return i._`!${e} || !${e}[${t}]`}(u,e),(()=>h(e))))))):!0!==u&&t.forIn("key",s,(e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const r in e)!0===e[r]&&n.push(i._`${t} !== ${r}`);return(0,i.and)(...n)}(u,e),(()=>h(e))))),l.props=!0,e.ok(i._`${a} === ${o.default.errors}`)}};t.default=s},7935:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>i._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:s,schemaCode:a,schema:l}=e;s||l&&"object"==typeof l?e.fail$data(i._`!${(0,r.useFunc)(t,o.default)}(${n}, ${a})`):e.fail(i._`${l} !== ${n}`)}};t.default=s},1846:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:e=>(0,i.validatePropertyDeps)(e)};t.default=r},8643:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>i._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:s,schema:a,schemaCode:l,it:c}=e;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,r.useFunc)(t,o.default);let p;if(u||s)p=t.let("valid"),e.block$data(p,(function(){t.assign(p,!1),t.forOf("v",l,(e=>t.if(i._`${d()}(${n}, ${e})`,(()=>t.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);p=(0,i.or)(...a.map(((t,r)=>function(e,t){const r=a[t];return"object"==typeof r&&null!==r?i._`${d()}(${n}, ${e}[${t}])`:i._`${n} === ${r}`}(e,r))))}e.pass(p)}};t.default=s},7060:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5882),r=n(3439),o=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),u=n(617),h=n(7935),d=n(8643),p=[i.default,r.default,o.default,s.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=p},2626:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,i.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=r},1163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,o="maxItems"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`${n}.length ${o} ${r}`)}};t.default=r},7307:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:s,it:a}=e,l="maxLength"===t?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,r.useFunc)(e.gen,o.default)}(${n})`;e.fail$data(i._`${c} ${l} ${s}`)}};t.default=s},5882:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=i.operators,o={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},s={message:({keyword:e,schemaCode:t})=>i.str`must be ${o[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>i._`{comparison: ${o[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(o),type:"number",schemaType:"number",$data:!0,error:s,code(e){const{keyword:t,data:n,schemaCode:r}=e;e.fail$data(i._`${n} ${o[t].fail} ${r} || isNaN(${n})`)}};t.default=a},4486:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,o="maxProperties"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`Object.keys(${n}).length ${o} ${r}`)}};t.default=r},3439:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>i.str`must be multiple of ${e}`,params:({schemaCode:e})=>i._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:r,it:o}=e,s=o.opts.multipleOfPrecision,a=t.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;e.fail$data(i._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};t.default=r},422:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match pattern "${e}"`,params:({schemaCode:e})=>r._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:o,schemaCode:s,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(e,o);e.fail$data(r._`!${c}.test(${t})`)}};t.default=o},4003:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>r.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>r._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:s,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(r.nil,d);else for(const t of n)(0,i.checkReportMissingProp)(e,t)}():function(){const o=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,o){e.setParams({missingProperty:n}),t.forOf(n,s,(()=>{t.assign(o,(0,i.propertyInData)(t,a,n,u.ownProperties)),t.if((0,r.not)(o),(()=>{e.error(),t.break()}))}),r.nil)}(o,n))),e.ok(n)}else t.if((0,i.checkMissingProp)(e,n,o)),(0,i.reportMissingProp)(e,o),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:i}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!i.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,o.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",s,(n=>{e.setParams({missingProperty:n}),t.if((0,i.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=s},617:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(208),r=n(9029),o=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>r.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>r._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(o,s){const a=t.name("item"),l=(0,i.checkDataTypes)(p,a,h.opts.strictNumbers,i.DataType.Wrong),c=t.const("indices",r._`{}`);t.for(r._`;${o}--;`,(()=>{t.let(a,r._`${n}[${o}]`),t.if(l,r._`continue`),p.length>1&&t.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),t.if(r._`typeof ${c}[${a}] == "number"`,(()=>{t.assign(s,r._`${c}[${a}]`),e.error(),t.assign(d,!1).break()})).code(r._`${c}[${a}] = ${o}`)}))}function f(i,a){const l=(0,o.useFunc)(t,s.default),c=t.name("outer");t.label(c).for(r._`;${i}--;`,(()=>t.for(r._`${a} = ${i}; ${a}--;`,(()=>t.if(r._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{e.error(),t.assign(d,!1).break(c)}))))))}e.block$data(d,(function(){const i=t.let("i",r._`${n}.length`),o=t.let("j");e.setParams({i,j:o}),t.assign(d,!0),t.if(r._`${i} > 1`,(()=>(p.length>0&&!p.some((e=>"object"===e||"array"===e))?m:f)(i,o)))}),r._`${u} === false`),e.ok(d)}};t.default=a},5488:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=s},857:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}"],sourceRoot:""}]);const a=s},6369:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=s},6314:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",i=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),i&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),i&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,i,r,o){"string"==typeof e&&(e=[[null,e,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);i&&s[u[0]]||(void 0!==o&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=o),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),r&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=r):u[4]="".concat(r)),t.push(u))}},t}},1354:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),o="/*# ".concat(r," */");return[t].concat([o]).join("\n")}return[t].join("\n")}},2017:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var i,r,o;if(Array.isArray(t)){if((i=t.length)!=n.length)return!1;for(r=i;0!=r--;)if(!e(t[r],n[r]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((i=(o=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(r=i;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,o[r]))return!1;for(r=i;0!=r--;){var s=o[r];if(!e(t[s],n[s]))return!1}return!0}return t!=t&&n!=n}},9982:function(e,t,n){var i;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,i,r,o){for(var s,a,l,c,u,h,d,p,m,f,g,y,b;o>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],p=n[7],f=0;f<16;f++)g=r+4*f,e[f]=(255&i[g])<<24|(255&i[g+1])<<16|(255&i[g+2])<<8|255&i[g+3];for(f=16;f<64;f++)y=((m=e[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=e[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,e[f]=(y+e[f-7]|0)+(b+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(p+(t[f]+e[f]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=h,h=u,u=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=p,r+=64,o-=64}return r}var i=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[i++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(i=n(this.temp,this.state,e,i,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[i++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,i=this.bufferLength,r=t/536870912|0,o=t<<3,s=t%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=r>>>24&255,this.buffer[s-7]=r>>>16&255,this.buffer[s-6]=r>>>8&255,this.buffer[s-5]=r>>>0&255,this.buffer[s-4]=o>>>24&255,this.buffer[s-3]=o>>>16&255,this.buffer[s-2]=o>>>8&255,this.buffer[s-1]=o>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=i;var r=function(){function e(e){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new i).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function o(e){var t=(new i).update(e),n=t.digest();return t.clean(),n}function s(e,t){var n=new r(e).update(t),i=n.digest();return n.clean(),i}function a(e,t,n,i){var r=i[0];if(0===r)throw new Error("hkdf: cannot expand more");t.reset(),r>1&&t.update(e),n&&t.update(n),t.update(i),t.finish(e),i[0]++}e.HMAC=r,e.hash=o,e.default=o,e.hmac=s;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,i){void 0===t&&(t=l),void 0===i&&(i=32);for(var o=new Uint8Array([1]),c=s(t,e),u=new r(c),h=new Uint8Array(u.digestLength),d=h.length,p=new Uint8Array(i),m=0;m<i;m++)d===h.length&&(a(h,u,n,o),d=0),p[m]=h[d++];return u.clean(),h.fill(0),o.fill(0),p},e.pbkdf2=function(e,t,n,i){for(var o=new r(e),s=o.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),u=new Uint8Array(i),h=0;h*s<i;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,o.reset(),o.update(t),o.update(a),o.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){o.reset(),o.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&h*s+p<i;p++)u[h*s+p]=l[p]}for(h=0;h<s;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return o.clean(),u}}(t);var r=t.default;for(var o in t)r[o]=t[o];"object"==typeof e.exports?e.exports=r:void 0===(i=function(){return r}.call(t,n,t,e))||(e.exports=i)}()},2787:(e,t,n)=>{"use strict";n.d(t,{I:()=>r});const i=new Uint32Array(65536),r=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,r=t.length,o=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[e.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let e=i[t.charCodeAt(c)];const n=e|a;e|=(e&s)+s^s,a|=~(e|s),s&=e,a&o&&l++,s&o&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,r=e.length,o=[],s=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let e=0;e<a;e++)s[e]=-1,o[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,r)+u;for(let t=u;t<h;t++)i[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],r=s[e/32|0]>>>e&1,c=o[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),p=l&h;d>>>31^r&&(s[e/32|0]^=1<<e),p>>>31^c&&(o[e/32|0]^=1<<e),d=d<<1|r,p=p<<1|c,l=p|~(u|d),a=d&u}for(let t=u;t<h;t++)i[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,p=Math.min(32,r-d)+d;for(let t=d;t<p;t++)i[e.charCodeAt(t)]|=1<<t;let m=r;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],a=s[e/32|0]>>>e&1,l=o[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let p=u|~(d|h),f=h&d;m+=p>>>r-1&1,m-=f>>>r-1&1,p>>>31^a&&(s[e/32|0]^=1<<e),f>>>31^l&&(o[e/32|0]^=1<<e),p=p<<1|a,f=f<<1|l,h=f|~(c|p),u=p&c}for(let t=d;t<p;t++)i[e.charCodeAt(t)]=0;return m})(e,t)}},9937:e=>{e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(e,t)=>{t.assign=function(e){e=e||{};var t,n,i,r=Array.prototype.slice.call(arguments).slice(1);for(t=0,i=r.length;t<i;t++)if(r[t])for(n in r[t])e[n]=r[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,i=e.order,r=e.size,o={},s=new Float32Array(10*i),a=new Float32Array(3*r);return n=0,e.forEachNode((function(e,t){o[e]=n,s[n]=t.x,s[n+1]=t.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=t.size||1,s[n+9]=t.fixed?1:0,n+=10})),n=0,e.forEachEdge((function(e,i,r,l,c,u,h){var d=o[r],p=o[l],m=t(e,i,r,l,c,u,h);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},t.assignLayoutChanges=function(e,t,n){var i=0;e.updateEachNodeAttributes((function(e,r){return r.x=t[i],r.y=t[i+1],i+=10,n?n(e,r):r}))},t.readGraphPositions=function(e,t){var n=0;e.forEachNode((function(e,i){t[n]=i.x,t[n+1]=i.y,n+=10}))},t.collectLayoutChanges=function(e,t,n){for(var i=e.nodes(),r={},o=0,s=0,a=t.length;o<a;o+=10){if(n){var l=Object.assign({},e.getNodeAttributes(i[s]));l.x=t[o],l.y=t[o+1],l=n(i[s],l),r[i[s]]={x:l.x,y:l.y}}else r[i[s]]={x:t[o],y:t[o+1]};s++}return r},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),i=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),r=new Worker(i);return t.revokeObjectURL(i),r}},8903:(e,t,n)=>{var i=n(1736),r=n(8153).Fd,o=n(2561),s=n(1782),a=n(9937);function l(e,t,n){if(!i(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=r("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,h=s.assign({},a,n.settings),d=s.validateSettings(h);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(t,c);for(p=0;p<l;p++)o(h,m.nodes,m.edges);if(!e)return s.collectLayoutChanges(t,m.nodes);s.assignLayoutChanges(t,m.nodes,u)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=c},2561:e=>{var t=10;e.exports=function(e,n,i){var r,o,s,a,l,c,u,h,d,p,m,f,g,y,b,v,w,C,A,S,x,E,_,M=n.length,I=i.length,T=e.adjustSizes,L=e.barnesHutTheta*e.barnesHutTheta,N=[];for(s=0;s<M;s+=t)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(e.outboundAttractionDistribution){for(m=0,s=0;s<M;s+=t)m+=n[s+6];m/=M/t}if(e.barnesHutOptimize){var $,P,R,O=1/0,k=-1/0,G=1/0,F=-1/0;for(s=0;s<M;s+=t)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),G=Math.min(G,n[s+1]),F=Math.max(F,n[s+1]);var D=k-O,B=F-G;for(D>B?F=(G-=(D-B)/2)+D:k=(O-=(B-D)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+F)/2,N[3]=Math.max(k-O,F-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,r=1,s=0;s<M;s+=t)for(o=0,R=3;;){if(!(N[o+5]>=0)){if(N[o+0]<0){N[o+0]=s;break}if(N[o+5]=9*r,h=N[o+3]/2,N[(d=N[o+5])+0]=-1,N[d+1]=N[o+1]-h,N[d+2]=N[o+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]-h,N[d+2]=N[o+2]+h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+h,N[d+2]=N[o+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+h,N[d+2]=N[o+2]+h,N[d+3]=h,N[d+4]=N[o+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,r+=4,$=n[N[o+0]+0]<N[o+1]?n[N[o+0]+1]<N[o+2]?N[o+5]:N[o+5]+9:n[N[o+0]+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+6]=n[N[o+0]+6],N[o+7]=n[N[o+0]+0],N[o+8]=n[N[o+0]+1],N[$+0]=N[o+0],N[o+0]=-1,$===(P=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27)){if(R--){o=$;continue}R=3;break}N[P+0]=s;break}$=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+7]=(N[o+7]*N[o+6]+n[s+0]*n[s+6])/(N[o+6]+n[s+6]),N[o+8]=(N[o+8]*N[o+6]+n[s+1]*n[s+6])/(N[o+6]+n[s+6]),N[o+6]+=n[s+6],o=$}}if(e.barnesHutOptimize){for(f=e.scalingRatio,s=0;s<M;s+=t)for(o=0;;)if(N[o+5]>=0){if(v=Math.pow(n[s+0]-N[o+7],2)+Math.pow(n[s+1]-N[o+8],2),4*(p=N[o+3])*p/v<L){if(g=n[s+0]-N[o+7],y=n[s+1]-N[o+8],!0===T?v>0?(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*N[o+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w),(o=N[o+4])<0)break;continue}o=N[o+5]}else if((c=N[o+0])>=0&&c!==s&&(v=(g=n[s+0]-n[c+0])*g+(y=n[s+1]-n[c+1])*y,!0===T?v>0?(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w)),(o=N[o+4])<0)break}else for(f=e.scalingRatio,a=0;a<M;a+=t)for(l=0;l<a;l+=t)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,f=e.scalingRatio,s=0;s<M;s+=t)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(e.outboundAttractionDistribution?m:1),u=0;u<I;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===T)for(s=0;s<M;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,_=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=_);else for(s=0;s<M;s+=t)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,_=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=_);return{}}},8153:(e,t)=>{function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},i=function(e){return void 0===e?t:e};"function"==typeof t&&(i=t);var r=function(t){return i(t[e])},o=function(){return i(void 0)};return"string"==typeof e?(n.fromAttributes=r,n.fromGraph=function(e,t){return r(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return r(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var r=t.extremities(n);return i(e(n,t.getEdgeAttributes(n),r[0],r[1],t.getNodeAttributes(r[0]),t.getNodeAttributes(r[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,r,o,s,a,l){return i(e(t,n,r,o,s,a,l))},n.fromPartialEntry=function(t,n,r,o){return i(e(t,n,r,o))},n.fromMinimalEntry=function(t,n){return i(e(t,n))}):(n.fromAttributes=o,n.fromGraph=o,n.fromEntry=o,n.fromMinimalEntry=o),n}(e,n)}},1736:e=>{e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934:function(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,i(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function i(e,t){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},i(e,t)}function r(e,t,n){return r=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var r=[null];r.push.apply(r,t);var o=new(Function.bind.apply(e,r));return n&&i(o,n.prototype),o},r.apply(null,arguments)}function o(e){var t="function"==typeof Map?new Map:void 0;return o=function(e){if(null===e||(o=e,-1===Function.toString.call(o).indexOf("[native code]")))return e;var o;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,s)}function s(){return r(e,arguments,n(this).constructor)}return s.prototype=Object.create(e.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,e)},o(e)}function s(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var i in arguments[t])e[i]=arguments[t][i];return e};function l(e,t,n,i){var r=e._nodes.get(t),o=null;return r?o="mixed"===i?r.out&&r.out[n]||r.undirected&&r.undirected[n]:"directed"===i?r.out&&r.out[n]:r.undirected&&r.undirected[n]:o}function c(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function h(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(e,t,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(e,t,i)}function p(e){return!(!c(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var b=Number.isNaN||function(e){return e!=e};function v(){v.init.call(this)}f.exports=v,f.exports.once=function(e,t){return new Promise((function(n,i){function r(n){e.removeListener(t,o),i(n)}function o(){"function"==typeof e.removeListener&&e.removeListener("error",r),n([].slice.call(arguments))}T(e,t,o,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&T(e,"error",t,{once:!0})}(e,r)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function A(e){return void 0===e._maxListeners?v.defaultMaxListeners:e._maxListeners}function S(e,t,n,i){var r,o,s,a;if(C(n),void 0===(o=e._events)?(o=e._events=Object.create(null),e._eventsCount=0):(void 0!==o.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),o=e._events),s=o[t]),void 0===s)s=o[t]=n,++e._eventsCount;else if("function"==typeof s?s=o[t]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(r=A(e))>0&&s.length>r&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=e,l.type=t,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return e}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(e,t,n){var i={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},r=x.bind(i);return r.listener=n,i.wrapFn=r,r}function _(e,t,n){var i=e._events;if(void 0===i)return[];var r=i[t];return void 0===r?[]:"function"==typeof r?n?[r.listener||r]:[r]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(r):I(r,r.length)}function M(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(e,t){for(var n=new Array(t),i=0;i<t;++i)n[i]=e[i];return n}function T(e,t,n,i){if("function"==typeof e.on)i.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,(function r(o){i.once&&e.removeEventListener(t,r),n(o)}))}}function L(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");w=e}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var i="error"===e,r=this._events;if(void 0!==r)i=i&&void 0===r.error;else if(!i)return!1;if(i){var o;if(t.length>0&&(o=t[0]),o instanceof Error)throw o;var s=new Error("Unhandled error."+(o?" ("+o.message+")":""));throw s.context=o,s}var a=r[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,t)}return!0},v.prototype.addListener=function(e,t){return S(this,e,t,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(e,t){return S(this,e,t,!0)},v.prototype.once=function(e,t){return C(t),this.on(e,E(this,e,t)),this},v.prototype.prependOnceListener=function(e,t){return C(t),this.prependListener(e,E(this,e,t)),this},v.prototype.removeListener=function(e,t){var n,i,r,o,s;if(C(t),void 0===(i=this._events))return this;if(void 0===(n=i[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete i[e],i.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(r=-1,o=n.length-1;o>=0;o--)if(n[o]===t||n[o].listener===t){s=n[o].listener,r=o;break}if(r<0)return this;0===r?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,r),1===n.length&&(i[e]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",e,s||t)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(e){var t,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var r,o=Object.keys(n);for(i=0;i<o.length;++i)"removeListener"!==(r=o[i])&&this.removeAllListeners(r);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(i=t.length-1;i>=0;i--)this.removeListener(e,t[i]);return this},v.prototype.listeners=function(e){return _(this,e,!0)},v.prototype.rawListeners=function(e){return _(this,e,!1)},v.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):M.call(e,t)},v.prototype.listenerCount=M,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var e=arguments,t=e.length,n=0;return new L((function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(e){var t=0,n=e.length;return new L((function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}}))},L.is=function(e){return e instanceof L||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=L,$={};$.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,$.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var P=N,R=$,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?P.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},F=G,D=function(e,t){for(var n,i=arguments.length>1?t:1/0,r=i!==1/0?new Array(i):[],o=0,s=F(e);;){if(o===i)return r;if((n=s.next()).done)return o!==t&&(r.length=o),r;r[o++]=n.value}},B=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(o(Error)),H=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),V=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),j=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B);function U(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function Y(e,t){this.key=e,this.attributes=t,this.clear()}function z(e,t,n,i,r){this.key=t,this.attributes=r,this.undirected=e,this.source=n,this.target=i}function q(e,t,n,i,r,o,s){var a,l,c,u;if(i=""+i,0===n){if(!(a=e._nodes.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" node in the graph.'));c=r,u=o}else if(3===n){if(r=""+r,!(l=e._edges.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" edge in the graph.'));var h=l.source.key,d=l.target.key;if(i===h)a=l.target;else{if(i!==d)throw new V("Graph.".concat(t,': the "').concat(i,'" node is not attached to the "').concat(r,'" edge (').concat(h,", ").concat(d,")."));a=l.source}c=o,u=s}else{if(!(l=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=r,u=o}return[a,c,u]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},Y.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},z.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,i=this.target.key;this.source[e][i]=this,this.undirected&&n===i||(this.target[t][n]=this)},z.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,i=this.target.key;this.undirected&&(e=t="undirected");var r=this.source[e],o=r[i];if(void 0===o)return r[i]=this,void(this.undirected&&n===i||(this.target[t][n]=this));o.previous=this,this.next=o,r[i]=this,this.target[t][n]=this},z.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][t],delete this.target[i][e]},z.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[i][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[i][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],a=o[1];return s.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){return q(this,t,n,e,i)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],a=o[1];return s.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r,o){var s=q(this,t,n,e,i,r,o),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r,o){var s=q(this,t,n,e,i,r,o),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new H("Graph.".concat(t,": updater should be a function."));var u=a.attributes,h=c(u[l]);return u[l]=h,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],a=o[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],a=o[1];if(!c(a))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],l=o[1];if(!c(l))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=q(this,t,n,e,i,r),s=o[0],a=o[1];if("function"!=typeof a)throw new H("Graph.".concat(t,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,o=""+arguments[1];if(!(i=l(this,r,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes[i]=r,this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof r)throw new H("Graph.".concat(t,": updater should be a function."));return o.attributes[i]=r(o.attributes[i]),this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete r.attributes[i],this.emit("edgeAttributesUpdated",{key:r.key,type:"remove",attributes:r.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return r.attributes=i,this.emit("edgeAttributesUpdated",{key:r.key,type:"replace",attributes:r.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return a(r.attributes,i),this.emit("edgeAttributesUpdated",{key:r.key,type:"merge",attributes:r.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new H("Graph.".concat(t,": provided updater is not a function."));return r.attributes=i(r.attributes),this.emit("edgeAttributesUpdated",{key:r.key,type:"update",attributes:r.attributes}),this}}}],X=N,J=G,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var r=!1;for(var o in t)if(o!==i){var s=t[o];if(r=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&r)return s.key}}function ne(e,t,n,i){var r,o,s,a=!1;for(var l in t)if(l!==i){r=t[l];do{if(o=r.source,s=r.target,a=n(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected),e&&a)return r.key;r=r.next}while(void 0!==r)}}function ie(e,t){var n,i=Object.keys(e),r=i.length,o=0;return new N((function(){do{if(n)n=n.next;else{if(o>=r)return{done:!0};var s=i[o++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function re(e,t,n,i){var r=t[n];if(r){var o=r.source,s=r.target;return i(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected)&&e?r.key:void 0}}function oe(e,t,n,i){var r=t[n];if(r){var o=!1;do{if(o=i(r.key,r.attributes,r.source.key,r.target.key,r.source.attributes,r.target.attributes,r.undirected),e&&o)return r.key;r=r.next}while(void 0!==r)}}function se(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var r,o,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var u=o,h=u.key,d=u.attributes,p=u.source,m=u.target;if(l=i(h,d,p.key,m.key,p.attributes,m.attributes,o.undirected),e&&l)return h}}function le(e,t,n,i,r,o){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,r.in,o),e&&s))return s;if("in"!==i&&(s=a(e,r.out,o,i?void 0:r.key),e&&s))return s}if("directed"!==n&&(s=a(e,r.undirected,o),e&&s))return s}function ce(e,t,n,i,r,o,s){var a,l=n?oe:re;if("undirected"!==t){if(void 0!==r.in&&"out"!==i&&(a=l(e,r.in,o,s),e&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(e,r.out,o,s),e&&a))return a}if("directed"!==t&&void 0!==r.undirected&&(a=l(e,r.undirected,o,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=r(c.key,c.attributes);if(e&&u)return c.key}}}function pe(e,t,n,i,r){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,r);if("string"==typeof n)return de(e,null,i,i[n],r)}var o,s=new he;if("undirected"!==t){if("out"!==n){if(o=de(e,null,i,i.in,r),e&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=de(e,s,i,i.out,r),e&&o)return o;s.wrap(i.out)}}if("directed"!==t&&(o=de(e,s,i,i.undirected,r),e&&o))return o}function me(e,t,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return e&&e.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function fe(e,t,n,i,r){for(var o,s,a,l,c,u,h,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(u=c.target,m=!0,h=r(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),m=!0,h=r(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!m&&(h=r(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function ge(e){if(!c(e))throw new H('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new H("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new H("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new H('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new H("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new H("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new H("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new H("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,r,o,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new H("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(o),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(o,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new z(i,r,l,u,a);e._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,u.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=r,e.emit("edgeAdded",h),r}function Ee(e,t,n,i,r,o,s,l,u){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new H("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new H("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(o=""+o,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(o),f=e._nodes.get(s);if(!n&&(d=e._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(u?!h:!l)return g;if(u){var y=p.attributes;p.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Se(e,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=Se(e,s,{}),w=!0),d=new z(i,r,m,f,l),e._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=r,e.emit("edgeAdded",b),[r,!0,v,w]}function _e(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,r=t.attributes,o=t.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),o?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:r,source:n.key,target:i.key,undirected:o})}var Me=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new H("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new H('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new H("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?U:"directed"===e.type?W:Y;h(s(t),"NodeDataClass",i);var r="geid_"+ve()+"_",o=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",(function(){var e;do{e=r+o++}while(t._edges.has(e));return e})),h(s(t),"_options",e),Ce.forEach((function(e){return h(s(t),e,t[e])})),d(s(t),"order",(function(){return t._nodes.size})),d(s(t),"size",(function(){return t._edges.size})),d(s(t),"directedSize",(function(){return t._directedSize})),d(s(t),"undirectedSize",(function(){return t._undirectedSize})),d(s(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(s(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(s(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",(function(){return"graphology"})),t}t(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(e){return this._nodes.has(""+e)},r.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.out.hasOwnProperty(t)}throw new H("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.undirected.hasOwnProperty(t)}throw new H("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new H("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},r.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},r.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},r.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},r.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},r.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},r.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},r.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},r.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},r.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},r.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},r.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},r.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},r.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},r.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},r.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},r.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},r.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},r.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},r.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},r.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},r.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},r.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(e===i)return r;if(e===r)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},r.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},r.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},r.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},r.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new H('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},r.mergeNode=function(e,t){if(t&&!c(t))throw new H('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},r.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new H('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var r=t?t({}):{};return n=new this.NodeDataClass(e,r),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:r}),[e,!0]},r.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{_e(this,t),t=t.next}while(t)}for(var r in n.in){t=n.in[r];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},r.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},r.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(e){return this._attributes[e]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},r.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.updateAttribute=function(e,t){if("function"!=typeof t)throw new H("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},r.replaceAttributes=function(e){if(!c(e))throw new H("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(e){if(!c(e))throw new H("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},r.updateAttributes=function(e){if("function"!=typeof e)throw new H("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new H("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new H("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},r.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new H("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new H("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=e(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},r.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new H("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},r.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new H("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},r.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new H("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new H("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):D(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(e){if("function"!=typeof e)throw new H("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},r.findNode=function(e){if("function"!=typeof e)throw new H("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},r.mapNodes=function(e){if("function"!=typeof e)throw new H("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(t=i.next()).done;)n=t.value,r[o++]=e(n.key,n.attributes);return r},r.someNode=function(e){if("function"!=typeof e)throw new H("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},r.everyNode=function(e){if("function"!=typeof e)throw new H("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},r.filterNodes=function(e){if("function"!=typeof e)throw new H("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),r=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(e,t){if("function"!=typeof e)throw new H("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new H("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=t,o=this._nodes.values();!0!==(n=o.next()).done;)r=e(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,r){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,r,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},r.import=function(e){var t,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new H("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new H("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(r=e.nodes,!Array.isArray(r))throw new H("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=r.length;t<n;t++){ge(o=r[t]);var u=o,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),r=e.edges,!Array.isArray(r))throw new H("Graph.import: invalid edges. Expecting an array.");for(t=0,n=r.length;t<n;t++){ye(s=r[t]);var m=s,f=m.source,g=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,f,g,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},r.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},r.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)})),t},r.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new j('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new j("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new j("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),r=this._edges.values();!0!==(t=r.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},r.toJSON=function(){return this.export()},r.toString=function(){return"[object Graph]"},r.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var i={},r={};this._edges.forEach((function(e,n){var o,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(o=l,l=c,c=o);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===r[u]?r[u]=0:r[u]++,a+="".concat(r[u],". ")):a+="[".concat(n,"]: "),i[a+=u]=e.attributes}));var o={};for(var s in this)this.hasOwnProperty(s)&&!Ce.has(s)&&"function"!=typeof this[s]&&"symbol"!==e(s)&&(o[s]=this[s]);return o.attributes=this._attributes,o.nodes=n,o.edges=i,h(o,"constructor",this.constructor),o},i}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(Me.prototype[Symbol.for("nodejs.util.inspect.custom")]=Me.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(e){["add","merge","update"].forEach((function(t){var n=e.name(t),i="add"===t?xe:Ee;e.generateKey?Me.prototype[n]=function(r,o,s){return i(this,n,!0,"undirected"===(e.type||this.type),null,r,o,s,"update"===t)}:Me.prototype[n]=function(r,o,s,a){return i(this,n,!1,"undirected"===(e.type||this.type),r,o,s,a,"update"===t)}}))})),function(e){K.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Node"),0),i(e,n("Source"),1),i(e,n("Target"),2),i(e,n("Opposite"),3)}))}(Me),function(e){Z.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Edge"),"mixed"),i(e,n("DirectedEdge"),"directed"),i(e,n("UndirectedEdge"),"undirected")}))}(Me),function(e){ee.forEach((function(t){!function(e,t){var n=t.name,i=t.type,r=t.direction;e.prototype[n]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):D(e._edges.keys(),e._edges.size);for(var n,i,r="undirected"===t?e.undirectedSize:e.directedSize,o=new Array(r),s="undirected"===t,a=e._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(o[l++]=i.key);return o}(this,i);if(1===arguments.length){e=""+e;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,i){var r=[];return le(!1,e,t,n,i,(function(e){r.push(e)})),r}(this.multi,"mixed"===i?this.type:i,r,o)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i,r){var o=[];return ce(!1,e,t,n,i,r,(function(e){o.push(e)})),o}(i,this.multi,r,s,t)}throw new H("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return ae(!1,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return le(!1,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return ce(!1,i,this.multi,r,a,t,n)}throw new H("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var r=0;"directed"!==i&&(r+=this.undirectedSize),"undirected"!==i&&(r+=this.directedSize),e=new Array(r);var s=0;t.push((function(t,i,r,o,a,l,c){e[s++]=n(t,i,r,o,a,l,c)}))}else e=[],t.push((function(t,i,r,o,s,a,l){e.push(n(t,i,r,o,s,a,l))}));return this[o].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push((function(e,i,r,o,s,a,l){t(e,i,r,o,s,a,l)&&n.push(e)})),this[o].apply(this,e),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new H("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new H("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var i=t;return n.push((function(t,n,r,o,s,a,l){i=e(i,t,n,r,o,s,a,l)})),this[o].apply(this,n),i}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return ae(!0,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return le(!0,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return ce(!0,i,this.multi,r,a,t,n)}throw new H("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,r,o,s,a){return t(e,n,i,r,o,s,a)})),!!this[o].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,r,o,s,a){return!t(e,n,i,r,o,s,a)})),!this[o].apply(this,e)}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n.slice(0,-1)+"Entries";e.prototype[o]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,i="undirected"===t,r=e._edges.values();return new N((function(){for(var e,t;;){if((e=r.next()).done)return e;if(t=e.value,!n||t.undirected===i)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}}))}(this,i);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var i=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(i=Q(i,ie(n.in))),"in"!==t&&void 0!==n.out&&(i=Q(i,ie(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(i=Q(i,ie(n.undirected))),i}(i,r,n)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i){var r=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&i in n.in&&(r=Q(r,se(n.in,i))),void 0!==n.out&&"in"!==t&&i in n.out&&(t||n.key!==i)&&(r=Q(r,se(n.out,i)))),"directed"!==e&&void 0!==n.undirected&&i in n.undirected&&(r=Q(r,se(n.undirected,i))),r}(i,r,s,t)}throw new H("Graph.".concat(o,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)}))}(Me),function(e){ue.forEach((function(t){(function(e,t){var n=t.name,i=t.type,r=t.direction;e.prototype[n]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var i=[];return pe(!1,e,t,n,(function(e){i.push(e)})),i}("mixed"===i?this.type:i,r,t)}})(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));pe(!1,"mixed"===i?this.type:i,r,n,t)}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(e,t){var n=[];return this[o](e,(function(e,i){n.push(t(e,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[o](e,(function(e,i){t(e,i)&&n.push(e)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(e,t,n){if(arguments.length<3)throw new H("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[o](e,(function(e,n){i=t(i,e,n)})),i}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n[0].toUpperCase()+n.slice(1,-1),s="find"+o;e.prototype[s]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return pe(!0,"mixed"===i?this.type:i,r,n,t)}};var a="some"+o;e.prototype[a]=function(e,t){return!!this[s](e,t)};var l="every"+o;e.prototype[l]=function(e,t){return!this[s](e,(function(e,n){return!t(e,n)}))}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n.slice(0,-1)+"Entries";e.prototype[o]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return me(null,n,n.undirected);if("string"==typeof t)return me(null,n,n[t])}var i=N.empty(),r=new he;return"undirected"!==e&&("out"!==t&&(i=Q(i,me(r,n,n.in))),"in"!==t&&(i=Q(i,me(r,n,n.out)))),"directed"!==e&&(i=Q(i,me(r,n,n.undirected))),i}("mixed"===i?this.type:i,r,t)}}(e,t)}))}(Me);var Ie=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new H("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new H('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),Te=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new H("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new H('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),Le=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Me),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new H('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),$e=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new H('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me);function Pe(e){e.from=function(t,n){var i=a({},t.options,n),r=new e(i);return r.import(t),r}}return Pe(Me),Pe(Ie),Pe(Te),Pe(Le),Pe(Ne),Pe($e),Me.Graph=Me,Me.DirectedGraph=Ie,Me.UndirectedGraph=Te,Me.MultiGraph=Le,Me.MultiDirectedGraph=Ne,Me.MultiUndirectedGraph=$e,Me.InvalidArgumentsGraphError=H,Me.NotFoundGraphError=V,Me.UsageGraphError=j,Me}()},944:(e,t)=>{"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var i=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var i=0,r=e.length,o=t.length,s=Math.floor(Math.max(r,o)/2)-1,a=new Array(r),l=new Array(o),c=0;c<r;c++)for(var u=Math.max(0,c-s);u<=Math.min(o,c+s+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++i,a[c]=l[u]=!0;break}if(0===i)return 0;var h=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(i/r+i/o+(i-(h/=2))/i)/3}(e,t,n),r=0;if(i>.7){for(var o=Math.min(e.length,t.length),s=0;e[s]===t[s]&&s<4&&s<o;)++r,s++;i+=.1*r*(1-i)}return i}},7106:e=>{"use strict";var t=e.exports=function(e,t,i){"function"==typeof t&&(i=t,t={}),n(t,"function"==typeof(i=t.cb||i)?i:i.pre||function(){},i.post||function(){},e,"",e)};function n(e,i,r,o,s,a,l,c,u,h){if(o&&"object"==typeof o&&!Array.isArray(o)){for(var d in i(o,s,a,l,c,u,h),o){var p=o[d];if(Array.isArray(p)){if(d in t.arrayKeywords)for(var m=0;m<p.length;m++)n(e,i,r,p[m],s+"/"+d+"/"+m,a,s,d,o,m)}else if(d in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,i,r,p[f],s+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,o,f)}else(d in t.keywords||e.allKeys&&!(d in t.skipKeywords))&&n(e,i,r,p,s+"/"+d,a,s,d,o)}r(o,s,a,l,c,u,h)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:e=>{"use strict";var t=[];function n(e){for(var n=-1,i=0;i<t.length;i++)if(t[i].identifier===e){n=i;break}return n}function i(e,i){for(var o={},s=[],a=0;a<e.length;a++){var l=e[a],c=i.base?l[0]+i.base:l[0],u=o[c]||0,h="".concat(c," ").concat(u);o[c]=u+1;var d=n(h),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(p);else{var m=r(p,i);i.byIndex=a,t.splice(a,0,{identifier:h,updater:m,references:1})}s.push(h)}return s}function r(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,r){var o=i(e=e||[],r=r||{});return function(e){e=e||[];for(var s=0;s<o.length;s++){var a=n(o[s]);t[a].references--}for(var l=i(e,r),c=0;c<o.length;c++){var u=n(o[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}o=l}}},7659:e=>{"use strict";var t={};e.exports=function(e,n){var i=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,r&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var o=n.sourceMap;o&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(o))))," */")),t.styleTagTransform(i,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},1407:(e,t,n)=>{"use strict";n.d(t,{R:()=>c});var i=n(4328),r=n(6082),o=n(567),s=n(826),a=n(2738);const l=31;async function c(e,t=!1,n){const a=s.GO.forColumn(e);let c;n??=new Map;const h=a.isHelm()?(0,o.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<h.length;e++)n.has(h[e])||n.set(h[e],`${n.size+1}`);if(a.isHelm())c=await i.functions.call("HELM:getMolFiles",{col:e}),c=function(e,t,n=!1){const i=new Array(e.length);for(let r=0;r<e.length;r++){let o=0,s=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const c=e.get(r);o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1;const u=parseInt(c.substring(o,o+3)),h=parseInt(c.substring(o+3,o+6));a+=`M V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){o=c.indexOf("\n",o)+1+l,s=c.indexOf(" ",o);const i=c.substring(o,s);a+=n?`M V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<h;e++){o=c.indexOf("\n",o)+1;const t=parseInt(c.substring(o,o+3).trim()),n=parseInt(c.substring(o+3,o+6).trim());a+=`M V30 ${e+1} ${parseInt(c.substring(o+6,o+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",i[r]=a}return i}(c,n,t);else{c=new Array(e.length);for(let i=0;i<e.length;i++){const e=u(a.getSplitted(i),n,t);c[i]=e}}return r.Column.fromStrings("monomericMols",c)}function u(e,t,n=!1){let i="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";i+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,i+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++){const o=e.getCanonical(r);o!==a._S&&(i+=n?`M V30 ${r+1} R${t.get(o)} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(o)}\n`)}i+="M V30 END ATOM\n",i+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)i+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return i+="M V30 END BOND\n",i+="M V30 END CTAB\n",i+="M END",i}},567:(e,t,n)=>{"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>Ji,SeqActivityCliffsEditor:()=>tr,SeqPaletteCustom:()=>Vi,SequenceSpaceEditor:()=>er,SplitToMonomersEditor:()=>Qi,SubsequenceSearchTopMenu:()=>Pr,_package:()=>Di,activityCliffs:()=>pr,addCopyMenu:()=>zr,alignSequences:()=>vr,applyNotationProviderForCyclized:()=>io,applyNotationProviderForDimerized:()=>ro,bioSubstructureFilter:()=>Dr,compositionAnalysis:()=>wr,compositionAnalysisWidget:()=>rr,convertDialog:()=>Sr,demoBioActivityCliffs:()=>Zr,demoBioAtomicLevel:()=>Xr,demoBioHelmMsaSequenceSpace:()=>Jr,demoBioSequenceSpace:()=>Kr,demoBioSimilarityDiversity:()=>qr,detectMacromoleculeProbe:()=>eo,diversitySearchTopMenu:()=>Nr,diversitySearchViewer:()=>Lr,fastaSequenceCellRenderer:()=>nr,getBioLib:()=>zi,getHelmMonomers:()=>Mr,getMolFromHelm:()=>no,getMonomerLib:()=>qi,getMonomerLibHelper:()=>Bi,getRegion:()=>ur,getRegionApp:()=>Vr,getRegionHelmApp:()=>jr,getRegionPanel:()=>Zi,getRegionTopMenu:()=>dr,getSeqHandler:()=>Ki,getSeqHelper:()=>to,helmPreprocessingFunction:()=>fr,hydrophobPalette:()=>Hi,importBam:()=>Ar,importFasta:()=>Cr,initBio:()=>Wi,libraryPanel:()=>Xi,longSeqTableFasta:()=>Wr,longSeqTableHelm:()=>Yr,longSeqTableSeparator:()=>Ur,macroMolColumnPropertyPanel:()=>ir,macromoleculeDifferenceCellRenderer:()=>sr,macromoleculePreprocessingFunction:()=>mr,manageLibrariesView:()=>Gr,manageMonomerLibraries:()=>kr,manageMonomersView:()=>hr,monomerCellRenderer:()=>xr,multipleSequenceAlignmentDialog:()=>br,saveAsFasta:()=>Fr,sdfToJsonLib:()=>Qr,searchSubsequenceEditor:()=>$r,separatorSequenceCellRenderer:()=>or,sequenceAlignment:()=>ar,sequenceIdentityScoring:()=>Rr,sequenceSimilarityScoring:()=>Or,sequenceSpaceTopMenu:()=>gr,sequenceTooltip:()=>Yi,similaritySearchTopMenu:()=>Tr,similaritySearchViewer:()=>Ir,splitToMonomersTopMenu:()=>_r,testDetectMacromolecule:()=>Er,toAtomicLevel:()=>yr,vdRegionsViewer:()=>cr,webLogoAggApp:()=>Hr,webLogoLargeApp:()=>Br,webLogoViewer:()=>lr});var i,r,o=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(r=i||(i={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var u=n(1858),h=n(5072),d=n.n(h),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),A=n.n(C),S=n(7939),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(S.A,x),S.A&&S.A.locals&&S.A.locals;var E=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};let _=null,M=null;function I(e,t){return e&&""!=e?e:t}class T{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter(),null==_))return null;const e=yield _.requestAdapterInfo();return e?I(e.description,I(e.vendor,"No GPU description available")):null}))}().then((e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class ${constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach((n=>{null!=e[n].value&&(t[n]=e[n].value)})),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new T,[c.c.T_SNE]:new L},this.dbScanParams=new $,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((e=>{const t=e.options.get(l.n3)??"",n=e.friendlyName??e.name,i=e.options.get(l.C0)??"",r=e.options.get(l._X)??"",o=e.options.get(l.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:r?r.split(","):[],distanceFunctions:o?o.split(","):[]})})),this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings((()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{u?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find((e=>!!this.columnFunctionsMap[e.name]))??null,t=s.input.column("Column",{table:this.tableInput.value,value:e,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach((e=>this.colInputRoot.append(e))),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;e&&(this.columnFunctionsMap={},e.columns.toList().forEach((e=>{Object.keys(this.supportedFunctions).forEach((t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,r=this.supportedFunctions[t].units,o=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!r.length||e.meta.units&&r.includes(e.meta.units);o&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))}))})),this.regenerateColInput())}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((e=>this.similarityMetricInputRoot.append(e))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach((n=>{const i=t[n],r="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(r.root),i.disable?(r.enabled=!1,s.tooltip.bind(r.input??r.root,i.disableTooltip??"")):s.tooltip.bind(r.input??r.root,i.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let r=2;r<t.inputs.length;r++){const o=t.inputs[r];(this.preprocessingFunctionSettings[o.name]||n.inputParams[t.inputs[r].name].value||o.defaultValue)&&(this.preprocessingFunctionSettings[o.name]=this.preprocessingFunctionSettings[o.name]??n.inputParams[o.name].value??o.defaultValue);const s=i.find((e=>e.property.name===o.name));s&&(null!==this.preprocessingFunctionSettings[o.name]&&void 0!==this.preprocessingFunctionSettings[o.name]&&(s.value=this.preprocessingFunctionSettings[o.name]),s.onChanged.subscribe((e=>{this.preprocessingFunctionSettings[o.name]=e})),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}const R=rxjs.operators;var O=n(6295);const k=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,i)}class F{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||o.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),g=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(h.set(o,i),s<m&&(m=s),a>f&&(f=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-m)/(f-m)})),i(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,o,s,a):0;r<u&&(console.log(`using threshold ${u}`),r=u),o.forEach(((e,t)=>o[t].threshold=r));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,u)=>{const h=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:p,threshold:r,fnNames:t,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:o}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:r,distance:o,idx:n}))}}));const p=await Promise.all(h),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,r=.8,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,threshold:r,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnKNN(e,t,r=15,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:u,fnNames:t,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of d)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,o=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=i&&(r.push(l),o.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,H,V=n(8774);(H=B||(B={})).none="none",H.bold="bold",H.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,r,o,s,a,l,c,u,h,d,p,m,f,g;const y=this.sp.getOptions().look,b=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;b||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const v=y.sizeColumnName?this.sp.dataFrame.col(y.sizeColumnName):null,w=this.sp.dataFrame.filter,C=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(w.get(this.lines.from[e])&&w.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:n,sizeTo:i}=this.getMarkersSizes(y,v,e),w=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let A=null==w?void 0:w.x,S=null==w?void 0:w.y;const x=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let E=null==x?void 0:x.x,_=null==x?void 0:x.y;const M=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),A&&S&&E&&_&&Math.hypot(E-A,_-S)/M>.01){if(b){const t=(null===(r=this.lines.colors)||void 0===r?void 0:r[e])?null===(o=this.lines.colors)||void 0===o?void 0:o[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const y=this.multipleLinesCounts[e];let v=null;if(y){t=this.getLineLength(A,S,E,_);const r=this.getPointOnDistance(A,S,E,_,i,t),o=this.getPointOnDistance(E,_,A,S,n,t);A=r.x,S=r.y,E=o.x,_=o.y,v=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(y,A,S,E,_,e):this.findControlPoint(y,E,_,A,S,e),this.ctx.moveTo(A,S),this.ctx.quadraticCurveTo(v.x,v.y,E,_)}else(!this.lines.skipShortLines||Math.pow(E-A,2)+Math.pow(_-S,2)>C)&&(this.ctx.moveTo(A,S),this.ctx.lineTo(E,_));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(A,S,E,_)),t>this.arrowWidth)){const e=y?null:this.getPointOnDistance(A,S,E,_,i,t),n=y?v.x:A,r=y?v.y:S;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:A,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:S,n,r)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case B.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,n){let i=3,r=3;return t?(i=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[n]))/2,r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[n]))/2):e.markerDefaultSize&&(i=e.markerDefaultSize/2,r=e.markerDefaultSize/2),{sizeFrom:i,sizeTo:r}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,r=null;const o=this.sp.getOptions().look,s=o.sizeColumnName?this.sp.dataFrame.col(o.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let l=0;l<this.lines.from.length;l++)if(a.get(this.lines.from[l])&&a.get(this.lines.to[l])&&this.visibility.getBit(l)){const{sizeFrom:a,sizeTo:c}=this.getMarkersSizes(o,s,l),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[l]),this.yAxisCol.get(this.lines.from[l])),h=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[l]),this.yAxisCol.get(this.lines.to[l]));if(this.multipleLinesCounts[l]){const n=this.getLineLength(u.x,u.y,h.x,h.y),i=this.getPointOnDistance(u.x,u.y,h.x,h.y,c,n),o=this.getPointOnDistance(h.x,h.y,null==u?void 0:u.x,null==u?void 0:u.y,a,n),s=this.lines.from[l]>this.lines.to[l]?this.findControlPoint(this.multipleLinesCounts[l],i.x,i.y,o.x,o.y,l):this.findControlPoint(this.multipleLinesCounts[l],o.x,o.y,i.x,i.y,l);r=this.calculateDistToCurveLine(l,e,t,i,o,s)}else r=this.calculateDistToStraightLine(e,t,u,h);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=l)}return n}calculateDistToStraightLine(e,t,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=r-2&&e<=o+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const r=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,o,r,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!d||d>g)&&(d=g),h[o]=Math.max(m,f),c[o]=a,u[o]=p}for(let e=0;e<c.length;e++)h[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,r,o){const s=n-r*((n-e)/o),l=i-r*((i-t)/o);return new a.Point(s,l)}findControlPoint(e,t,n,i,r,o){const s=t+(i-t)/2,l=n+(r-n)/2;let c=s-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*u,l-d/2*c):new a.Point(s-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,r){const o=Math.atan2(i-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}const U="dimensionality-reducer-terminate-event";var W,Y,z=n(3629);async function q(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(U).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,r,s,a,l);return c=c.map((e=>(0,z.S8)(e))),c}(Y=W||(W={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const K={[W.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[W.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[Z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[Z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},Q={[Z.HAMMING]:e=>Math.ceil(e/30),[Z.EUCLIDEAN]:e=>Math.ceil(e/30),[Z.MANHATTAN]:e=>Math.ceil(e/30),[Z.TANIMOTO]:e=>Math.ceil(e/60),[Z.SOKAL]:e=>Math.ceil(e/60),[Z.COSINE]:e=>Math.ceil(e/60),[Z.ASYMMETRIC]:e=>Math.ceil(e/60),[Z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[Z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[Z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[Z.Difference]:e=>1,[Z.OneHot]:e=>Math.ceil(e/40)},ee={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var te=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function ne(e,t,n,i){return e.map(((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${J[e](t[i],i)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${K[i](e.length)}\n }\n \n `}let ie=0;const re="cliffsDf",oe=new u.Subject,se="activity_difference",ae="SALI_index",le="similarity",ce="line_index",ue=["1_molecule","2_molecule"],he="filterCliffs";async function de(e,t,i,r,l,c,u,h,d,p,m,f,g,y,b,v,w){ie++;const C=c/100;let A,S=!1;const x=f.inputs,I=await f.apply({[x[0].name]:t,[x[1].name]:u,...d.preprocessingFuncArgs??{}});let T=[];if(h===N){const t=await function(e,t,i,r,o,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:r,distanceFns:o,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([I.entries],c,[1],"MANHATTAN",[u],[I.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),T=[t.embedX,t.embedY]}else T=await q([I.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[I.options??{}]});if(T.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<T.length;++t)e.columns.addNewFloat(i[t]).init((e=>T[t][e]));let L=null;if(d.useWebGPU)try{L=await function(e,t=.8,n,i,r,o){return te(this,void 0,void 0,(function*(){const s=yield function(){return E(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==_))return null;let e=!1;if(M&&(M.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!M||e){const e=1e9,t=_.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield _.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield _.requestDevice(),M}}return M}))}();if(!s)return null;const a=Object.values(Z);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(W).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(o.length!==e.length||o.length!==n.length||o.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=Z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,o;let s=null;const a=e.some((e=>"string"==typeof e))?(s="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(s="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(s="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(s="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(s="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!ee[s]||!ee[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=Q[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(t===Z.NEEDLEMAN_WUNSCH||t===Z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=i.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(o=i.gapExtensionPenalty)&&void 0!==o?o:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===Z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);i.range=t-e}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,o[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=W.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*u);h.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${ne(n,h.map((e=>e.maxEntryLen)),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),$=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);T[e]=O,L[e]=R,N[e]=i,$[e]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),G=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,D=k*Uint32Array.BYTES_PER_ELEMENT;let B=D;const H=15&D;0!==H&&(B+=16-H);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let U=0;new Uint32Array(j,U,g).set(T),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set(L),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set(N),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set($),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f.length).set(f),U+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,U,c).set(r),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const Y=G*Uint32Array.BYTES_PER_ELEMENT;let z=Y;const q=15&Y;0!==q&&(z+=16-q),z=Math.max(z,16);const K=s.createBuffer({label:"supp info buffer",size:z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(X,J,e.suppInfoBuffer.length).set(e.suppInfoBuffer),J+=e.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const te=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=te;const re=15&te;0!==re&&(ie+=16-re);const oe=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:oe}}]}),ae=s.createBuffer({label:"results out buffer",size:oe.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(oe,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let r=0;const o=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,r,g).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(o.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(h),ce.push(d),ue.push(p),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(de),me=new Uint32Array(de),fe=new Float32Array(de);let ge=0;for(let e=0;e<le.length;e++)pe.set(le[e],ge),me.set(ce[e],ge),fe.set(ue[e],ge),ge+=le[e].length;return V.destroy(),K.destroy(),oe.destroy(),ae.destroy(),{i:pe,j:me,distance:fe}}))}([I.entries],C,[u],W.MANHATTAN,[1],[I.options??{}])}catch(e){console.error(e)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new D).calc(I.entries,u,C,I.options));const $=await async function(e,t){const n=e.distance.map(((n,i)=>{const r=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?r/n:1/0})),i=e.distance.map((e=>1-e)),r=e.i,o=e.j,s=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{s.set(e.i[n],!0),s.set(e.j[n],!0)})),{simVals:i,saliVals:n,n1:r,n2:o,cliffsBitSet:s}}(L,l),P=function(e,t,n,i,r,o,s){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(s.get(i[e])>s.get(r[e])?l[i[e]]+=n[e]:l[r[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,$.saliVals,$.n1,$.n2,0,l);e.columns.add(P);const O=$.cliffsBitSet,k=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}($.saliVals),G=.8/(k.max-k.min),F=w?o.shell.view("Browse").preview:o.shell.getTableView(e.name),H=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:P.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(e,t,n,i,r,o,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return ue.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),o),u.col(e).semType=r})),u.columns.addNewFloat(se).init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),u.columns.addNewInt(ce).init((e=>e)),u.columns.addNewFloat(ae).init((e=>t.saliVals[e])),u.columns.addNewFloat(le).init((e=>t.simVals[e])),u.name=`${re}${ie}`,{lines:c,linesDf:u}}(e,$,t,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ae).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(H,i[0],i[1],V.lines,B.none),Y=b?b(V.linesDf,ue).sort([ae],[!1]):V.linesDf.plot.grid().sort([ae],[!1]);Y.col(ce)&&(Y.col(ce).visible=!1),e.temp[".cliffsDfGrid"]=Y;const z=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{w&&F.addViewer(Y),F.dockManager.dock(Y,"down",null,"Activity cliffs",v??.2)}));z.classList.add("scatter_plot_link","cliffs_grid"),H.root.append(z);const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(H.dataFrame.setTag(he,i[0]),e.filter.and(O),oe.next(i[0])):(H.dataFrame.setTag(he,""),e.filter.setAll(!0),oe.next(""))}});K.root.classList.add("scatter_plot_link","show_only_cliffs"),H.root.append(K.root),oe.subscribe((e=>{K.enabled=""===e||e===i[0]}));let X=!1;H.onEvent("d4-before-draw-scene").subscribe((t=>{X?X=!1:K.value&&(setTimeout((()=>{e.filter.and(O)}),100),X=!0)}));const J=o.events.onViewerClosed.subscribe((e=>{e.args.viewer===H&&(F.dockManager.close(Y.root),J.unsubscribe(),F.subs=F.subs.filter((e=>e!==J)))}));return F.subs.push(J),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<V.linesDf.rowCount;e++)V.lines.widths[e]=e===V.linesDf.currentRowIdx?3:1;U.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===ue[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,p=(n<r?n:r)+s/2-h/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+h,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],V.lines.from[n]),H.dataFrame.get(i[1],V.lines.from[n]),H.dataFrame.get(i[0],V.lines.to[n]),H.dataFrame.get(i[1],V.lines.to[n]));H.zoom(a,u,c,h),K.value?e.filter.and(O):!0===K.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,r,a,l,c,u){const h=t.getPane("Cliff Details");s.empty(h.root);const d=u({points:[n,i],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{o.shell.o=t.root}),500)}(e,A,V.lines.from[r],V.lines.to[r],r,t,l,V.linesDf.get(ae,r),y);const n=H.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<V.linesDf.rowCount;e++){const n=V.linesDf.selection.get(e);n&&(t.set(V.lines.from[e],!0),t.set(V.lines.to[e],!0)),V.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),U.linesToRender=V.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<V.lines.colors.length;e++)V.lines.colors[e]="0,128,0";U.linesToRender=V.lines})(Y.dataFrame))})),U.lineClicked.subscribe((t=>{if(S=!0,U.currentLineId=t.id,-1!==t.id){const n=V.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==t.id&&(V.linesDf.currentRowIdx=t.id,e.currentRowIdx=V.lines.from[t.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(Y.sortByColumns,Y.sortTypes);Y.scrollToCell(ue[0],i.indexOf(t.id))}),500)}})),U.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),H.addProperty("similarityLimit","double",C),A=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),o.shell.o=e.root,e}(),H}var pe,me=n(2003),fe=n(826),ge=n(3516),ye=n(6718),be=n(2738),ve=n(3077);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var we=n(9192);class Ce{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ae extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ce}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Se=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function xe(e,t,i){return Se(this,void 0,void 0,(function*(){return new Promise((function(r,o){const s=new Worker(new URL(n.p+n.u(705),n.b));s.postMessage({distMatArray:e,n:t,methodCode:i}),s.onmessage=({data:{error:e,clusterMatrix:t}})=>{s.terminate(),e?o(e):r(t)}}))}))}var Ee,_e,Me,Ie=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function Te(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function Le(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ee||(Ee={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(_e||(_e={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Me||(Me={})),Object.prototype.toString;var Ne=n(6873),$e=n(4356),Pe=n(6717),Re=n(4870),Oe=n(1991),ke=n.n(Oe),Ge=n(9322);const Fe="#808080",De="rgb(0,0,0)",Be=Ge.zS;var He,Ve;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(He||(He={})),function(e){e.MSA="MSA",e.classic="classic"}(Ve||(Ve={}));const je=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=Ve.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function Ue(e,t,n,i,r,o,s){var a,l,c;const u=Object.assign(Object.assign({},je),s);s.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let h=t.substring(0),d=u.last?"":u.separator;u.drawStyle===Ve.MSA&&(d="");let p=!0,m=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(p=u.gridCell.cell.column.temp["color-code"]??!0,m=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];m&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=h==e?.3:u.transparencyRate),m&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=h!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(h=Be(h,u.maxLengthOfMonomer));const g=h+d;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));let b=u.monomerTextSizeMap[h].width;const v=o/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));const w=u.monomerTextSizeMap[d].width;function C(t,r){const o=p?u.color:De;e.fillStyle=o,e.globalAlpha=u.transparencyRate,u.drawStyle===Ve.classic&&(e.fillText(h,n+t,i+v),e.fillStyle=Fe,e.fillText(d,n+r,i+v)),u.drawStyle===Ve.MSA&&e.fillText(h,n+t,i+v)}y=y.width,u.drawStyle===Ve.MSA&&(b=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const A=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>r)return C(A,A+b),n+A+b+w;{const e=(r-y)/2;return C(e,e+b),n+A+e+b}}var We=n(6882),Ye=n(4152);const ze={[me.YI.DNA]:"RNA",[me.YI.RNA]:"RNA",[me.YI.PT]:"PEPTIDE",[me.YI.UN]:"PEPTIDE"};var qe=n(6642);const Ke={true:"1",false:"0"};var Ze=n(4139);const Xe="rgb(100,100,100)",Je=me.zS;function Qe(e,t,n,i,r){return e?Math.max(Math.min(e.canvas.width/r-n,i)):Math.max(t.canvas.width/r-n,0)}function et(e){const t=!ke().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,r]of ke().enumerate(e)){let o=t;r<e.length&&(o+=`${t?"":"-"}${i}`),n.push(o)}return[n,t]}class tt extends a.GridCellRenderer{padding=5;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const[n,i,r]=(0,qe.h)(e),o=r.rendererBack;if(!o)return;const a=e.bounds,l=t.offsetX-e.gridColumn.left+(e.gridColumn.left-a.x),c=o.getPosition(e.tableRowIndex,l,a.width),u=fe.GO.forColumn(i).getSplitted(e.tableRowIndex).canonicals;if(null!==c&&c<u.length){const e=u[c],n=[];let r=o._monomerStructureMap[e];r=o._monomerStructureMap[e]=(()=>{const t=fe.GO.forColumn(i).alphabet??me.YI.UN,n=ze[t],r=qi();return r?r.getTooltip(n,e):s.divText("Monomer library is not available")})(),n.push(r),s.tooltip.show(s.divV(n),t.x+16,t.y+16)}else s.tooltip.hide()}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,[l,c,u]=(0,qe.h)(o);if(!c)return;const h=c.temp;let d=0,p=(Di.properties?Di.properties.maxMonomerLength:4)??50;if(He.maxMonomerLength in c.tags){const e=parseInt(c.getTag(He.maxMonomerLength));p=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];p=!isNaN(e)&&e?e:50}const[m,f,g]=(0,qe.h)(o);let y=g.rendererBack;y||(y=g.rendererBack=new We.J(l,c,Di.logger,p,(()=>{const e=fe.GO.forColumn(c);return{seqHandler:e,monomerCharWidth:7,separatorWidth:e.isMsa()?8:d,monomerToShort:Je}}))),e.save();try{c.temp[".mm.cellRenderer.settingsChanged"]!==Ke.true&&y.monomerLengthLimit==p||(d=h[".mm.cellRenderer.gapLength"]??d,y.setMonomerLengthLimit(p),y.setSeparatorWidth(y.isMsa()?8:d),c.temp[".mm.cellRenderer.settingsChanged"]=Ke.false);const[s,u]=y.getCellMonomerLengths(o.tableRowIndex,i),m=(s.length,o.cell.value,o.cell.rowIndex),f=c.getTag(me.gp.alphabet),g=50;i=Qe(l?.grid,e,t,i,a),e.beginPath(),e.rect(t+this.padding,n+this.padding,i-this.padding-1,r-2*this.padding),e.clip(),e.font="12px monospace",e.textBaseline="top";const b=c.meta.units,v=c.getTag(me.gp.aligned),w=(0,me.ny)(f),C=c.getTag(me.gp.separator)??"",A=y.props.separatorWidth+1*y.props.monomerCharWidth,S=Math.ceil(i/A),x=fe.GO.forColumn(c),E=h["reference-sequence"],_=h["current-word"];_&&-1===c?.dataFrame?.currentRowIdx&&(h["current-word"]=null);const M=(()=>{const e=x.getSplitter(S);return ke()(e(null!=E&&""!=E?E:_??"").originals).toArray()})(),I=x.getSplitted(m);let T=Xe,L=Ve.classic;v&&v.includes("MSA")&&b==me.Hi.SEPARATOR&&(L=Ve.MSA);const N=Math.min(I.length,S);for(let s=0;s<N;++s){const a=I.getOriginal(s);T=w.get(a),e.fillStyle=Xe;const l={color:T,pivot:0,left:!0,transparencyRate:1,separator:C,last:s===I.length-1,drawStyle:L,maxWord:u,wordIdx:s,gridCell:o,referenceSequence:M,maxLengthOfMonomer:p,monomerTextSizeMap:y._monomerLengthMap,logger:Di.logger};if(Ue(e,a,t+this.padding,n,i,r,l),g>i)break}}catch(e){const[t,n]=(0,we.AP)(e);y.logger.error(t,void 0,n),y.errors.push(e)}finally{e.restore()}}}class nt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ze.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell,u=o.tableColumn,h=c.value??"",d=u.tags[me.gp.separator],p=u.meta.units;i=Qe(l,e,t,i,a);const[m,f]=h.split("#"),g=(0,Ge.Iv)(p,d);it(e,t,n,i,r,ke()(g(m).canonicals).toArray(),ke()(g(f).canonicals).toArray(),p)}}function it(e,t,n,i,r,o,s,a,l,c){if(o.length!==s.length){const e=function(e,t){let n=0,i=0;const r=e.length>t.length?e:t,o=e.length>t.length?t:e;for(let e=0;e<o.length;e++)r[e]===o[e]&&n++;const s=r.length-o.length;for(let e=r.length-1;e>s;e--)r[e]===o[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(fe.b9[me.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ke()(t).toArray()):e=l(ke()(e).toArray()),{subParts1:e,subParts2:t}}(o,s);o=e.subParts1,s=e.subParts2}const u=e.measureText(et(o).join("")),h=e.measureText(et(s).join("")),d=Math.max(u.width,h.width);l&&(i=d+4*o.length,e.canvas.width=d+4*o.length);let p=Math.max(t,t+(i-(d+4*o.length))/2)+5;const m=Math.max(n,n+(r-28)/2);e.save(),e.beginPath(),e.rect(t,n,l?d+4*o.length:i,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Ye.oT.Color;"HELM"!==a&&(f=(0,me.ny)(a.substring(a.length-2)));for(let t=0;t<o.length;t++){const n=o[t],a=s[t],l=f.get(n);if(n!=a){const o=f.get(a),s=Ue(e,n,p,m-7,i,r,{color:l,pivot:0,left:!0}),u=Ue(e,a,p,m+7,i,r,{color:o,pivot:0,left:!0});p=Math.max(u,s),c&&(c[t]=rt(n,a,l,o,m,7,r))}else p=Ue(e,n,p,m,i,r,{color:l,pivot:0,left:!0,transparencyRate:.5});p+=4}e.restore()}function rt(e,t,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(et([e]).join("")).width,u=l.measureText(et([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",Ue(l,e,0,r-o,h,s,{color:n,pivot:0,left:!0}),Ue(l,t,0,r+o,h,s,{color:i,pivot:0,left:!0}),a}var ot,st=n(8070),at=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ot||(ot={}));const lt=new class{constructor(){this.regionTypes=[ot.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=at.fH.Entropy,this.filterSource=at.Fo.filterSource}};var ct=n(7602),ut=n(8047);const ht=ot;var dt,pt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(dt||(dt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(pt||(pt={}));const mt=lt;class ft extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(pt.skipEmptyPositions,mt.skipEmptyPositions,{category:dt.DATA}),this.regionTypes=this.stringList(pt.regionTypes,mt.regionTypes,{category:dt.DATA,choices:Object.values(ht).filter((e=>e!=ht.Unknown))}),this.chains=this.stringList(pt.chains,mt.chains,{category:dt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(pt.fitWidth,mt.fitWidth,{category:dt.LAYOUT}),this.positionWidth=this.float(pt.positionWidth,mt.positionWidth,{category:dt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(pt.positionHeight,mt.positionHeight,{category:dt.LAYOUT,choices:Object.keys(at.fH)}),this.filterSource=this.string(pt.filterSource,mt.filterSource,{category:dt.BEHAVIOR,choices:Object.values(at.lT)}),this.viewSyncer=new ct.g(Di.logger)}static viewerCounter=-1;viewerId=++ft.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case pt.regionTypes:case pt.chains:this.setData(this.regions)}switch(e.name){case pt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case pt.fitWidth:case pt.positionWidth:this.calcSize();break;case pt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.positionHeight]:this.positionHeight});this.calcSize();break;case pt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;Di.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){Di.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){Di.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const o=t.find((t=>t.order==n[e]&&t.chain==r));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(at.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Di.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Di.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,r=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[ut.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(pt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[ut.n5.filterSource]:this.filterSource})}}}))}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,st.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}var gt=n(6625),yt=n(6863);async function bt(e,t,n="Morgan"){const i=e.length,r=fe.GO.forColumn(e),o=Array(i);let s=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<i;t++){if(null===l[c[t]]||e.isNone(t)){o[t]=null;continue}o[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[t]+=a.get(i)}}let u={};if(t===yt.Z.MONOMER_CHEMICAL_DISTANCE||t===yt.Z.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,ye.A7)(e,n),i={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{i[a.get(e)]=t}));const r=o.reduce(((e,t)=>Math.max(e,t.length)),0);u={scoringMatrix:t.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:u}}var vt=n(2780),wt=n(8115);function Ct(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))})),t}function At(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},r=fe.GO.forColumn(e.seqCol),o=xt(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),r.units,i);return t.append(s.div(o,{style:{width:"300px",overflow:"scroll"}})),t.append(Et(i)),t.append(St("Activity delta",Math.abs(n[0]-n[1]))),t.append(St("Cliff",e.sali)),t}function St(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function xt(e,t,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");return r.height=30,it(o,0,0,0,30,ke()(e.canonicals).toArray(),ke()(t.canonicals).toArray(),n,!0,i),r}function Et(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function _t(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(me.gp.separator,e.col(t[0]).getTag(me.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class Mt extends a.JsViewer{name="";distanceMetric;limit;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];moleculeColumn;moleculeColumnName;initialized=!1;tags=[a.TAGS.UNITS,me.gp.aligned,me.gp.separator,me.gp.alphabet];preComputeDistanceMatrix=!1;constructor(e){super(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}computeRequested;renderPromise=Promise.resolve();render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(o.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var It=n(1407),Tt=n(439);const Lt={gapPenalty:1,matchScore:1,gapSymbol:fe.b9[Tt.Hi.FASTA],localAlignment:!1};class Nt extends Mt{cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new u.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;constructor(e){super("similarity"),this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=fe.GO.forColumn(this.moleculeColumn);await(e.isHelm()?this.computeByChem():this.computeByMM());const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=a.Column.string(t,this.idxs.length).init((e=>this.moleculeColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.moleculeColumn.getTag(e))));const n=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const i=n.plot.grid();i.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));i.cell("score",r).cell.value=null,(this.demo?o.shell.view("Browse").preview:o.shell.v).grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),(0,Re.K)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,It.R)(this.moleculeColumn),t=(a.DataFrame.fromColumns([e]),await o.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:e,molecule:e.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=t.getCol("indexes"),this.scores=t.getCol("score")}async computeByMM(){const e=this.moleculeColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await bt(this.moleculeColumn,yt.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new D).getKNN(n,yt.Z.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,r=e.col(i),a=fe.GO.forColumn(this.moleculeColumn),l=fe.GO.forColumn(r),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...Lt,...n},r=e.length,o=t.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,u=i.localAlignment?l[1]:o,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(s[c-1][u-1],s[c-1][u],s[c][u-1]);s[c][u]==s[c-1][u-1]+i.matchScore&&n==s[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):s[c][u]==s[c-1][u]-i.gapPenalty?(d.push(i.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):s[c][u]==s[c][u-1]-i.gapPenalty?(h.push(i.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...Array.from(e.canonicals).splice(0,c),...h.reverse(),...i.localAlignment?Array.from(e.canonicals).splice(l[0],r):[]],d=[...Array.from(t.canonicals).splice(0,u),...d.reverse(),...i.localAlignment?Array.from(t.canonicals).splice(l[1],o):[]];const p=c,m=u;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:h=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Ge.Mu(h,i.gapSymbol),seq2Splitted:new Ge.Mu(d,i.gapSymbol)}}(c,u),d=xt(h.seq1Splitted,h.seq2Splitted,l.units,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(Et(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),o.shell.o=p.root}}class $t extends Mt{diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new u.Subject;constructor(){super("diversity"),this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.moleculeColumn){const e=fe.GO.forColumn(this.moleculeColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.moleculeColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.moleculeColumn.getTag(e))));const i=a.DataFrame.fromColumns([n]);i.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Re.K)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,It.R)(this.moleculeColumn);a.DataFrame.fromColumns([e]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await bt(this.moleculeColumn,yt.Z.LEVENSHTEIN)).seqList,t=new F(!0,!1),n=await t.calc(e,yt.Z.LEVENSHTEIN);t.terminate();const i=this.moleculeColumn.length,r=(o=i,(e,t)=>o*e+t-Math.floor((e+2)*(e+1)/2));var o;this.renderMolIds=function(e,t,n){function i(e,t){let n=null,i=null;for(const r of e){const e=t(r);(null==i||e>i)&&(n=r,i=e)}return n}const r=[(s=e-1,Math.floor(function(e){return Math.random()*e}(s)))],o=new Set;var s;for(let t=0;t<e;++t)r.includes(t)||o.add(t);for(;r.length<t;){const e=i(o.values(),(e=>Math.min.apply(Math,r.map((function(t,i){return n(e,t)})))));null!=e&&(r.push(e),o.delete(e))}return r}(i,Math.min(i,this.limit),((e,t)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(t)?0:n[r(e,t)]))}}var Pt,Rt,Ot=n(5433),kt=n(3890),Gt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Pt||(Pt={}));class Ft{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[e,t,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Dt extends Ft{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Bt extends Dt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Pt.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(Pt.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),r=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Pt.TYPE)&&-1!==e.indexOf(Pt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Pt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Pt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Pt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Pt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Pt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Pt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ht extends Dt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Vt{constructor(){}static getInstance(e){if(Vt.isMolfileV2K(e))return new Bt(e);if(Vt.isMolfileV3K(e))return new Ht(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Bt.isValidMolfile(e)}static isMolfileV3K(e){return Ht.isValidMolfile(e)}}!function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(Rt||(Rt={}));class jt{constructor(e){this.monomerLib=e}getCappedRotatedMonomer(e,t){const n=this.monomerLib.getMonomer(e,t);return n?n.molfile:null}}var Ut=n(5488),Wt={};Wt.styleTagTransform=A(),Wt.setAttributes=b(),Wt.insert=g().bind(null,"head"),Wt.domAPI=m(),Wt.insertStyleElement=w(),d()(Ut.A,Wt),Ut.A&&Ut.A.locals&&Ut.A.locals;class Yt{source;error;_monomers={};_onChanged=new u.Subject;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){this.source=t,this.error=n,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t===fe.b9[me.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ke().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=function(e){let t;switch(e){case Rt.BASE:case Rt.SUGAR:case Rt.LINKER:case Rt.NUCLEOTIDE:case"nucleotide":t="RNA";break;case Rt.AA:t="PEPTIDE";break;case Rt.CHEM:t="CHEM";break;case Rt.BLOB:t="BLOB";break;default:t="PEPTIDE",console.warn(`Unexpected HelmType '${e}'`)}return t}(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Vt.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateLibInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={}),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,$e.ub)().then((e=>{this.assignDuplicatePreferances(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferances(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const r=e.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((e=>e.lib?.source===r));o?this._monomers[n][i]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ke().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=s.div([],{classes:"ui-form ui-tooltip"}),i=this.getMonomer(e,t);if(i){const e=i.symbol;i.name,n.append(s.divH([s.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),s.div([i.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let r;r=i.molfile?o.chem.svgMol(i.molfile,void 0,void 0,t):i.smiles?s.divV([o.chem.svgMol(i.smiles,void 0,void 0,t),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),n.append(s.div(r,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(s.divText(i.lib?.source??"Missed in libraries"))}else n.append(s.divV([s.divText(`Monomer '${t}' of type '${e}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}class zt{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,r){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class qt{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var Kt=n(7433),Zt=n.n(Kt),Xt=n(1913),Jt=n.n(Xt);class Qt{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Zt())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Jt()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const r of e){const e=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,r,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${e}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}class en{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,i){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++en.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await o.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),r=JSON.parse(i),s=new Qt(r);return new en(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists($e.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText($e.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists($e.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete($e.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists($e.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),r=await i.readAsText(t);n=JSON.parse(r);const o={},s=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(o[t]={},s.push(t)),o[t][n]=e})),new Yt(o,t)}async loadSetFromFile(e,t,n){let i={};const r=new a.FileSource(t),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,r=n.polymerType,o=n.monomerType,s=n.set;return new zt(e,i,r,o,s)}));return new qt(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText($e.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${$e.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Di.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Di.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Di.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText($e.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Di.logger.debug(`${e}, OUT`)})),Di.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list($e.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring($e.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list($e.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring($e.Es.length)))}}class tn{constructor(){}static _instance;static getInstance(){return tn._instance||(tn._instance=new tn),tn._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class nn{logger;_monomerLib=new Yt({},"MAIN");_monomerSets=new qt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,st.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++nn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return nn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferances(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await en.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,$e.ub)()]),r=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((e=>this.readLibrary($e.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Yt({},e,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((t=>this.readSet($e.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new qt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,$e.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,$e.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new nn(Di.logger);return e._eventManager=tn.getInstance(),e})()),e}}var rn=n(1757),on=n.n(rn),sn=n(3017),an={};an.styleTagTransform=A(),an.setAttributes=b(),an.insert=g().bind(null,"head"),an.domAPI=m(),an.insertStyleElement=w(),d()(sn.A,an),sn.A&&sn.A.locals&&sn.A.locals;var ln=n(3151);class cn{constructor(e,t=[],n={}){this.onItemChanged=new u.Subject,this.onAddingItemChanged=new u.Subject,this.onItemAdded=new u.Subject,this.onItemRemoved=new u.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,r;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const r=s.divText(i);r.style.fontWeight="bold",this._root.appendChild(r)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(r=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==r?r:void 0,!0);for(const t of e)this._root.appendChild(t)}}getItemDiv(e={},t){var n,i;const r=[],o={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):s.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),r.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),o[c.name]=u,u.onChanged.subscribe((()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})})),u.root.style.alignItems="center",l=u}let c=null;if(t)c=s.icons.add((()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(o).forEach((t=>{e[t]=o[t].value})),this._items.push(e),this.onItemAdded.next(e),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return r;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",r}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const un={A:new V.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new V.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new V.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new V.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new V.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new V.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new V.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new V.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new V.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new V.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new V.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new V.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},hn={RNA:{A:new V.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new V.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new V.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:un};async function dn(e,t,n=0){if(!Object.keys(hn).includes(t))return null;const i=await async function(e){const t=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;const r=hn[t];let o=0,s=null;for(const[e,t]of Object.entries(r)){const r=(0,O.$1)(i,t);r>o&&r>=n&&(o=r,s=e)}return s}var pn,mn=n(857),fn={};fn.styleTagTransform=A(),fn.setAttributes=b(),fn.insert=g().bind(null,"head"),fn.domAPI=m(),fn.insertStyleElement=w(),d()(mn.A,fn),mn.A&&mn.A.locals&&mn.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(pn||(pn={}));const gn={[pn.MONOMER]:a.COLUMN_TYPE.STRING,[pn.SYMBOL]:a.COLUMN_TYPE.STRING,[pn.NAME]:a.COLUMN_TYPE.STRING,[pn.R_GROUPS]:a.COLUMN_TYPE.STRING,[pn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[pn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[pn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[pn.AUTHOR]:a.COLUMN_TYPE.STRING,[pn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[pn.ID]:a.COLUMN_TYPE.INT,[pn.META]:a.COLUMN_TYPE.STRING,[pn.SOURCE]:a.COLUMN_TYPE.STRING};class yn{monomerLibManamger;static VIEW_NAME="Manage Monomers";_newMonomer=ln.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new An(e,(()=>this.activeMonomerLib),(async()=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e)}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await nn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new yn(e)}return this.instance}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))));e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await o.dapi.files.writeAsText($e.so+e,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(e)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)o.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e){const t=await this.getMonomersDf(e);return this.tv=a.TableView.create(t,!0),this.tv.grid.col(pn.NAME).width=100,this.tv.subs.push(o.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(()=>{this.cloneMonomer(this.tv.dataFrame.rows.get(t))})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>_n(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>_n(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(()=>{const e=_n(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e&&(o.shell.v=e),e??null}async getViewRoot(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){this.libInput&&(this.libInput.items=t),e&&(this.libInput.value=e);const n=await this.getMonomersDf(e);return this.tv.dataFrame=n,this.tv.grid.col(pn.NAME).width=100,this.tv}e??=t[0],this.tv=await this.getMonomersTableView(e);let n=this.tv.getRibbonPanels();n.forEach(((e,t)=>{n[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),n=n.filter((e=>e.length>0));const i=s.icons.edit((()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||this.cloneMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),r=s.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=t.map((e=>_n(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=_n(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(r,(()=>(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]).length>0?"Delete selected monomers":"Delete monomer"));const l=s.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{t=await o.dapi.files.readAsText($e.so+e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");n.push([i,r,l]),this.tv.setRibbonPanels(n),this.tv.name=yn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:t,nullable:!1,onValueChanged:async()=>{try{const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const c=this._newMonomerForm.form;return c.prepend(this.libInput.root),this.tv.dockManager.dock(c,a.DOCK_TYPE.LEFT,null,void 0,.4),this.tv}cloneMonomer(e){return this._newMonomer=_n(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary($e.so,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),a.DataFrame.create();const t=this.activeMonomerLib.getPolymerTypes().flatMap((e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map((t=>this.activeMonomerLib.getMonomer(e,t))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const r=Array.from(i);r.sort();for(const[e,t]of Object.entries(gn))if(n.columns.addNew(e,t),e===pn.R_GROUPS)for(const e of r)n.columns.addNew(e,a.COLUMN_TYPE.STRING);for(let e=0;e<t.length;e++){let i=xn(t[e].rgroups,t[e].smiles,t[e].molfile);i=bn(i),t[e].rgroups=Cn(t[e].rgroups);const o=r.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?wn(i,"capGroupSmiles"):""}));n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...o,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,t[e].createDate,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""])}return n.col(pn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((e=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;this.cloneMonomer(n.rows.get(n.currentRowIdx))}catch(e){console.error(e)}})),n}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}}function bn(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const vn=["alternateId","capGroupName","capGroupSMILES","label"];function wn(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function Cn(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(vn,e),n=wn(t,"capGroupSMILES"),i=wn(t,"alternateId"),r=wn(t,"capGroupName"),o=wn(t,"label")??"R1";if(n&&i&&r||o.length<2)return t;if(i&&-1!==i.indexOf(`${o}-`)){const e=i.replace(`${o}-`,"");r||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${o.substring(1)}][${e}]`)}else r&&(n||(t.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(t.alternateId=`${o}-${r}`));return t}))}class An{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}saveValidationResult=null;triggerMolChange=!0;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";let e=this.molSketcher.getSmiles();if(!e)return void(this.rgroupsGrid.items=[]);e=xn([],e);const t=this.findRgroupsInSmiles(e);if(0===t.length)return this.rgroupsGrid.items=[],void this.rgroupsGrid.render();const n=t.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items.length!==n.length&&(this.rgroupsGrid.items=n),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const i=await dn(En(e,n),this.polymerTypeInput.value??"");i&&(this.monomerNaturalAnalogInput.value=i)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new cn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new cn(l,[]),this.onMonomerInputChanged()}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled");const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Cn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),e.naturalAnalog||dn(En(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}))}validateInputs(){if(!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;if(this.rgroupsGrid.items.length<1)return"At least 1 R-group is required";for(const e of this.rgroupsGrid.items)for(const[t,n]of Object.entries(e))if(!n)return`R-group ${t} field is required for ${e.label}`;return this.rgroupsGrid.hasErrors()?"R-group fields contain errors":null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){const e=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]),t=s.tabControl({Monomer:e,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root])},!1);t.header.style.marginBottom="10px";const n=s.buttonsInput([this.saveButton]);return s.tooltip.bind(n,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,t.root,n],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=xn(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await o.dapi.files.readAsText($e.so+t);i=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const r=e.map((e=>Sn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=r.map((e=>i[e])),l=s.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,u=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,h=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(u)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await o.dapi.files.writeAsText($e.so+t,JSON.stringify(i)),await(await nn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),h.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await o.dapi.files.readAsText($e.so+t);n=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const i=Sn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),r=this.getMonomersDataFrame()?.col(pn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{n=n.filter((t=>t.symbol!==e.symbol||t.polymerType!==e.polymerType)),n.push({...e,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText($e.so+t,JSON.stringify(n)),await(await nn.getInstance()).loadLibraries(!0),await this.refreshTable(),o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const e=_n(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=xn([],e);let t=o.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=function(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")||e.includes("V3000"))),r=Number.parseInt(t[i].trim().split(" ")[0]),o={};for(let e=i+1;e<i+1+r;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const r=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(o[e-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[e-i]=s)}const s=Object.values(o);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M RGP ${s.length} ${Object.entries(o).map((([e,t])=>`${e} ${t}`)).join(" ")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return t.join("\n")}(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},r=this.getMonomerLib()?.source;r?await this.addMonomerToLib(i,r):o.shell.warning("Monomer library source is not specified")}}function Sn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function xn(e,t,n){const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(r,e),r=bn(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function En(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=wn(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}function _n(e){return{symbol:e.get(pn.SYMBOL),name:e.get(pn.NAME),molfile:"",smiles:e.get(pn.MONOMER),polymerType:e.get(pn.POLYMER_TYPE),monomerType:e.get(pn.MONOMER_TYPE),naturalAnalog:e.get(pn.NATURAL_ANALOG),id:e.get(pn.ID),rgroups:JSON.parse(e.get(pn.R_GROUPS)??"[]"),meta:JSON.parse(e.get(pn.META)??"{}"),author:e.get(pn.AUTHOR),createDate:e.get(pn.CREATE_DATE)}}class Mn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class In{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Mn(e)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,e),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),r.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Tn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Tn._instance||(Tn._instance=new Tn,await Tn._instance.refresh(),(await nn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Tn._instance.refresh()))),Tn._instance.refresh(),Tn._instance}async refresh(){this.settings=await(0,$e.ub)();const e=await nn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new In(n,this.monomers[t][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,$e.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),e.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Ln(){await Pn.showDialog()}class Nn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Nn.instancePromise&&(Nn.instancePromise=(async()=>{const e=new Nn,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Nn.instancePromise}static async reloadWidget(){const e=await Nn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe((async()=>await this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await $n.createControlsForm();return on()(e).addClass("monomer-lib-controls-form"),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class $n{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((async([e,t])=>{await this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Di.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then((e=>e.getFileManager())),await(0,$e.ub)()]);return new $n(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.form(e);return on()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();on()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;Di.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=s.icons.edit((async()=>{o.shell.v=await(await yn.getInstance()).getViewRoot(e)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${e}`),i.addOptions(a),i.addOptions(r),Di.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,$e.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class Pn{constructor(){}static _instance;dialog;closeDialogSubject$=new u.Subject;static async showDialog(){Pn._instance||(Pn._instance=new Pn,Pn._instance.closeDialogSubject$.subscribe((()=>{Pn._instance.dialog=void 0}))),Pn._instance.dialog||(Pn._instance.dialog=await Pn._instance.getDialog()),Pn._instance.dialog.show()}async getDialog(){const e=tn.getInstance(),t=(await Nn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});return on()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t),n.onClose.subscribe((()=>this.closeDialogSubject$.next())),n}}class Rn{constructor(){}static _instance;_view;_duplicateManager;libManager;async getView(){const e=tn.getInstance(),t=(await Nn.getInstance()).widget,n=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),i=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),r=s.splitH([s.divV([t.root,s.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);this._view=o.shell.newView("Manage Monomer Libraries",[r]),s.tools.waitForElementInDom(r).then((()=>{setTimeout((()=>{const e=Array.from(r.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const s=i-o;n.style.width=`${s}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((async()=>{try{const e=Rn._instance;e&&e._view&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))}))}static async showView(){if(Rn._instance||(Rn._instance=new Rn),Rn._instance._duplicateManager||(Rn._instance._duplicateManager=await Tn.getInstance()),Rn._instance.libManager||(Rn._instance.libManager=await nn.getInstance()),Rn._instance._view&&Array.from(o.shell.views).find((e=>e.id&&e.id===Rn._instance._view.id)))return o.shell.v=Rn._instance._view,void await Rn._instance._duplicateManager.refresh();Rn._instance.getView()}async mergeSelectedLibs(){const e="Library with this name already exists",t=await nn.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=u(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=r.value;return e.endsWith(".json")||(e+=".json"),e}function u(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}r.addValidator(u),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(t,e,!1);const n=await(0,$e.ub)();n.exclude=l,await(0,$e.Eu)(n),await this.libManager.loadLibraries(!0),await Nn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var On,kn=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};class Gn{constructor(e,t,n=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>kn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>kn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>kn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Gn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var e,t,n;o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1;const i=o.shell.isInDemo?Array.from(o.shell.view("Browse").dockManager.rootNode.children)[0]:Array.from(o.shell.dockManager.rootNode.children)[0];this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,i,""),(null===(t=null===(e=i.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=i.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return kn(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{yield this._steps[this._currentStep].func()}catch(e){o.shell.isInDemo=!1,console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,st.cb)(c));const u=s.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}if(o.shell.isInDemo){const e=o.shell.view("Browse");(null==e?void 0:e.preview)instanceof a.TableView&&(yield o.data.detectSemanticTypes(e.preview.dataFrame))}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return kn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return kn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),e.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return kn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return kn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Gn.currentObject=null,o.shell.isInDemo=!1}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return kn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.newView(this.name),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Fn(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),Di.logger.error(e.message,void 0,n)}Gn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(On||(On={}));const Dn="samples/FASTA_PT_activity.csv";async function Bn(){const e="Dendrogram",t=a.Func.find({package:e,name:"getTreeHelper"});if(0===t.length)throw new Error(`Package "${e}" must be installed for TreeHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}async function Hn(){return await o.functions.call("Dendrogram:getDendrogramService",{})}const Vn="samples/FASTA_PT_activity.csv",jn="sequence";const Un="samples/FASTA_PT_activity.csv";var Wn=n(8152);const Yn="samples/HELM.csv";var zn=n(966),qn=n(608),Kn=n(1619);class Zn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ke()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case ut.n5.fixWidth:case ut.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Xn{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var Jn=n(5785);const Qn=new class{tooltipHandlerTemp="tooltip-handler.Monomer"},ei={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class ti{gridCol;constructor(e){this.gridCol=e,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(e,t,n){if(e.grid.dart!=this.gridCol.grid.dart||e.gridColumn.dart!=this.gridCol.dart||!e.tableColumn||!e.isTableCell)return!1;const i=e.tableColumn.getTag(Tt.gp.alphabet),r=e.cell.value,a=e.grid.canvas.getBoundingClientRect(),l=e.bounds.right+a.left-4,c=e.bounds.bottom+a.top-4,u=qi();if(!u)return s.tooltip.show(s.divText("Monomer library is not available."),l,c),!0;const h=new jt(u),d=i===me.YI.DNA||i===me.YI.RNA?"RNA":(me.YI.PT,"PEPTIDE"),p=h.getCappedRotatedMonomer(d,r),m=s.div(r),f=p?o.chem.svgMol(p,void 0,void 0,ei):null;return s.tooltip.show(s.divV([m,...f?[f]:[]]),l,c),!0}static getOrCreate(e){let t=e.temp[Qn.tooltipHandlerTemp];return t||(t=e.temp[Qn.tooltipHandlerTemp]=new ti(e)),t}}class ni extends a.GridCellRenderer{get name(){return Ze.uF.MONOMER}get cellType(){return Ze.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,r,o,s){if(o.gridRow<0)return;ti.getOrCreate(o.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,me.ny)(o.cell.column.getTag(Tt.gp.alphabet)),l=o.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c;const u=Math.max(2,Math.floor(.15*i));e.fillText((0,me.zS)(l,u),t+i/2,n+r/2,i)}}class ii{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ri extends Map{_onPropertyChanged=new u.Subject;get onPropertyChanged(){return this._onPropertyChanged}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class oi extends a.Package{_properties;_rdKitModule;get rdKitModule(){return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ii(super.logger,e.debug)}completeInit(e){this._rdKitModule=e,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,we.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var si=n(2174);class ai extends a.Widget{viewed=!1;seqCol;wlViewer=null;constructor(e){super(s.divV([])),this.seqCol=e}async init(){const e=fe.GO.forColumn(this.seqCol),t=Di.properties.tooltipWebLogo,n=this.seqCol.getTag(at.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function li(e,t,n,i){const r=fe.GO.forColumn(e);let o=null,s=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(o=e),r.posList[e]==n&&(s=e);if(null===o&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(o,s,a)}const ci={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(me.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class ui{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??ci;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(me.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(me.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class hi{call;inputs=new class{table;sequence;region;start;end;name};constructor(e){this.call=e;const t=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const n=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:n,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,t(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&fe.GO.forColumn(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=fe.GO.forColumn(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?fe.GO.forColumn(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),i.options.add(r)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(me.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const r=e.options[i],o=JSON.parse(r.value);o&&t===o.start&&n===o.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Di.handleErrorUI(e)}))})).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=s.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Di.handleErrorUI(e)}))}));return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var di=n(8754);class pi{separator;separatorSplitter;splitter;constructor(e){this.separator=e,this.separatorSplitter=(0,Ge.dh)(this.separator),this.splitter=this._splitter.bind(this)}_splitter(e){const t=this.separatorSplitter(e);return new mi(t.originals,fe.b9[me.Hi.SEPARATOR])}async getHelm(e,t){const n="SequenceTranslator",i=a.Func.find({package:n,name:"polyToolConvert2"});if(0==i.length)throw new Error(`Package '${n}' must be installed for Cyclized notation provider.`);const r=i[0],o=await r.prepare({table:e.dataFrame,seqCol:e,...t}),s=a.Func.find({package:n,name:"getPolyToolConvertEditor"})[0];return(await s.prepare({call:o}).call()).getOutputParamValue()}}class mi extends Ge.Mu{seqCList;_canonicals=null;get canonicals(){if(!this._canonicals){const e=this.length;this._canonicals=new Array(e);for(let t=0;t<e;++t)this._canonicals[t]=this.getCanonical(t)}return this._canonicals}getCanonical(e){if(this.isGap(e))return be._S;let t=this.seqCList[e];if(null===t){const n=this.getOriginal(e);t=n,")"===n[n.length-1]&&(t=this.seqCList[e]=n.replace(/\(\d+\)$/,""))}return t}constructor(e,t){super(e,t),this.seqCList=new Array(this.length).fill(null)}}class fi extends pi{}var gi=n(8312),yi=n(9124);const bi=OCL;var vi=n(2582);class wi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var Ci=n(6956);class Ai{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===Ci.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Si{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,r=n*Math.cos(e)-i*Math.sin(e),o=n*Math.sin(e)+i*Math.cos(e);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:o}}))}}class xi extends Si{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Ei{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class _i extends Ei{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Mi extends wi{constructor(e,t){super(t);const n=Vt.getInstance(e);this.atoms=new xi(n),this.bonds=new _i(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends Si{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,r,a)=>t+o+i+s+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Ti extends Ei{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,r,o,s)=>`${n}${t[0]}${r}${t[1]}${s}`))}))}}class Li extends wi{constructor(e,t){super(t);const n=Vt.getInstance(e);this.atoms=new Ii(n),this.bonds=new Ti(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni{static getInstance(e,t){if(Vt.isMolfileV2K(e))return new Mi(e,t);if(Vt.isMolfileV3K(e))return new Li(e,t);throw new Error("Unsupported molfile version")}}class $i{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];constructor(e,t,n,i,r,o){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;Vt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=Ni.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),n.bondedRGroupsMap.has(t)&&this.removeRGroups(n.bondedRGroupsMap.get(t)),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i)return i.get_v3Kmolblock();throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Pi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new vi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){const i=new $i(e,t,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(i)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new Array(this.monomerWrappers.length);for(const[n,r]of ke().enumerate(this.monomerWrappers)){const o=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines()),i[r]={position:r,symbol:n.monomerSymbol,atoms:ke().count(o).take(n.atomCount).toArray(),bonds:ke().count(s).take(n.bondCount).toArray()}}const r=e.length,o=t.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END BOND"].join("\n")}}class Ri{constructor(e){this.molfileHandler=Vt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}var Oi=n(1054);class ki{helmColumn;df;libHelper;helmHelper;constructor(e,t,n,i){this.helmColumn=e,this.df=t,this.libHelper=n,this.helmHelper=i}convertToSmiles(e){const t=this.getSmilesList(e),n=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(n,t.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){const t=bi.Molecule.fromMolfile(n[e]).toMolfileV3();i[e]=t.replace("STERAC1","STEABS");const o=e/n.length*100;r.update(o,`${o?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t){const n=this.convertToMolfileV3KColumn(t).toList().map((e=>{if(""===e)return null;const n=t.get_mol(e);return n?(n.set_new_coords(),n.normalize_depiction(1),n.straighten_depiction(!0),n):null})),i=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return e?this.getMolV3000ViaOCL(n,i):a.Column.fromStrings(i,n.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=this.getPolymerGraphColumn(),n=this.libHelper.getMonomerLib(),i=t.toList().map(((t,i)=>{const r=this.helmColumn.get(i);if(!r)return"";let o;try{o=this.getPolymerMolfile(r,t,e,n)}catch(e){const[t,n]=(0,we.AP)(e);Di.logger.error(t,void 0,n),o=Oi.v.empty()}return o.molfile})),r=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",r,i)}convertToMolfileV3K(e){const t=this.getPolymerGraphColumn(),n=this.libHelper.getMonomerLib(),i=t.toList().map(((t,i)=>{const r=this.helmColumn.get(i);if(!r)return{molfile:"",monomers:[]};let o;try{o=this.getPolymerMolfile(r,t,e,n)}catch(e){const[t,n]=(0,we.AP)(e);Di.logger.error(t,void 0,n),o=Oi.v.empty()}return o}));return i}getPolymerGraphColumn(){const e=this.helmColumn.toList(),t=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",t)}getPolymerMolfile(e,t,n,i){const r=new Ri(t),o=new Pi(e,n,i);return r.monomerSymbols.forEach(((e,t)=>{const n=r.getMonomerShifts(t);o.addMonomer(e,t,n)})),o.compileToMolfile()}}class Gi{libHelper;helmHelper;rdKitModule;constructor(e,t,n){this.libHelper=e,this.helmHelper=t,this.rdKitModule=n}getHelmToMolfileConverter(e,t){return new ki(t,e,this.libHelper,this.helmHelper)}async helmToAtomicLevel(e,t,n){const i=(e,t)=>e?e.columns.getUnusedName(t):t,r=e.dataFrame,o=i(r,`molfile(${e})`),s=i(r,`~${o}-hl`),l=this.getHelmToMolfileConverter(r,e),c=l.convertToMolfileV3K(this.rdKitModule),u=c.map((e=>{const t=e.molfile;if(""===t)return null;const n=this.rdKitModule.get_mol(t);return n?(n.set_new_coords(),n.normalize_depiction(1),n.straighten_depiction(!0),n):null}));let h;h=t?l.getMolV3000ViaOCL(u,o).toList():u.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}));const d=c.map((e=>{const t=e.monomers,n={},i={};for(const[e,r]of ke().enumerate(t)){if(r>=2)continue;const t=[Math.random(),Math.random(),Math.random(),.3];for(const i of e.atoms)n[i]=t;for(const n of e.bonds)i[n]=t}return{atoms:Object.keys(n).map((e=>parseInt(e))),bonds:Object.keys(i).map((e=>parseInt(e))),highlightAtomColors:n,highlightBondColors:i}})),p=a.Column.fromStrings(o,h);p.semType="Molecule",p.temp[gi.P]=s;const m=a.Column.fromList(a.COLUMN_TYPE.OBJECT,s,d);return m.semType="Molecule-substruct",{molCol:p,molHighlightCol:m}}static getInstance(){let e=window.$seqHelperPromise;return null==e&&(e=window.$seqHelperPromise=(async()=>{if(!Di.initialized)throw new Error("Bio package is not initialized, call Bio:getSeqHelper");return new Gi(await nn.getInstance(),await(0,yi.b)(),Di.rdKitModule)})()),e}}async function Fi(e,t,n,i){const r=await async function(e,t,n,i){const r=(0,ve.R)(t),o=fe.GO.forColumn(t).getNewColumnFromList("ref",[n]),s=fe.GO.forColumn(o).getSplitted(0),l=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):be._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===o[t]&&++l[n];l[n]/=e.length}return s}(s,r):i===pe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,ye.uL)(n,e)}(s,r):null;if(null===l)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return l.name=e.columns.getUnusedName(l.name),e.columns.add(l),l}(e,t,n,i);for(let e=0;e<r.length;e++)t.isNone(e)&&r.set(e,null,!1);return r}const Di=new oi;async function Bi(){return await nn.getInstance()}let Hi=null;class Vi{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}let ji=null,Ui=null;async function Wi(){const e="Bio: _package.initBio()";let t,n;Di.logger.debug(`${e}, start`);const i=window.performance.now();await Promise.all([(async()=>{n=await nn.getInstance();const e=await(0,$e.ub)();e.explicit&&(e.explicit=[],await(0,$e.Eu)(e)),await Promise.all([n.loadMonomerLib(),n.loadMonomerSets()]),ji=n.getMonomerLib(),Ui=n.getMonomerSets()})(),(async()=>{const e=await Di.getProperties(),t=new ri(e);Di.properties=t})(),(async()=>{t=await(0,Pe.j)()})()]).finally((()=>{const t=window.performance.now();Di.logger.debug(`${e}, loading ET: ${t-i} ms`)})),Di.completeInit(t);const r=[],o=[],s=ji.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(s).forEach((e=>{r.push(e);const n=s[e].replaceAll("#R","O "),i=t.get_mol(n),a=JSON.parse(i.get_descriptors()).CrippenClogP;o.push(a),i?.delete()}));const a=o.reduce(((e,t)=>e+t),0)/o.length||0,l={};for(let e=0;e<r.length;e++)l[r[e]]=o[e]<a?"#4682B4":"#DC143C";Hi=new Vi(l),Di.logger.debug(`${e}, end`)}function Yi(e){const t=new ai(e);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)})),t}function zi(){return ji}function qi(){return ji}function Ki(e){return fe.GO.forColumn(e)}function Zi(e){const t="getRegionTopMenu",n=a.Func.find({package:Di.name,name:t});if(1!==n.length)throw new Error(`Package '${Di.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new hi(i).widget()}async function Xi(e){return async function(){const e=s.label("Manage monomer libraries");return on()(e).addClass("d4-link-action"),e.onclick=async()=>await Ln(),new a.Widget(e)}()}function Ji(e){try{new hi(e).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),Di.logger.error(t,void 0,n)}}function Qi(e){const t=new Xn;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function er(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function tr(e){const t=new Ae({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function nr(){return new tt}function ir(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=Di.properties?Di.properties.maxMonomerLength:4;if(He.maxMonomerLength in e.tags){const t=parseInt(e.getTag(He.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Ke.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"}),r=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Ke.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),o=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),l=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),c=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),u=s.inputs([i,r,l,o,c]);return new a.Widget(u)}(e)}function rr(e){return(0,si.j)(e)}function or(){return new tt}function sr(){return new nt}function ar(e,t,n,i,r){const o=new gt.$(i,r,n,t);return"Local alignment"==e?o.smithWaterman():o.needlemanWunsch()}function lr(){return new ut.oP}function cr(){return new ft}function ur(e,t,n,i){return li(e,t??null,n??null,i??null)}async function hr(){const e=await yn.getInstance();await e.getViewRoot()}async function dr(e,t,n,i,r){const s=li(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}async function pr(e,t,n,i,r,u,h,d,p){if(!(0,zn.V)(t,"Activity Cliffs"))return;const m=Te(e),f={units:t.meta.units,aligned:t.getTag(me.gp.aligned),separator:t.getTag(me.gp.separator),alphabet:t.getTag(me.gp.alphabet)},g=u,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,g,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,h,Ct,At,_t,void 0,p),v=r===c.c.UMAP?2e5:2e4,w=r===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{b().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():b().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,we.AP)(e);throw Di.logger.error(t,void 0,n),e})).finally((()=>{C.close()}))}async function mr(e,t,n=1,i=.6,r="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:o,options:s}=await bt(e,t,r);return{entries:o,options:{...s,gapOpen:n,gapExtend:i}}}async function fr(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,wt.BQ)(e,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=V.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}async function gr(e,t,i,r,c,u,h,d,p){const m=p?o.shell.view("Browse").preview:o.shell.tv.dataFrame==e?o.shell.tv:void 0;if((0,zn.V)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??={},await async function(e,t,i,r,c,u,h,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={}){const b={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==u.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?f.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,w=async()=>{const w=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let C;try{const A=Te(e);function S(n,r,o){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!C&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??Le(t,i)}))),f[l.YP]&&(C?.root&&s.setUpdateIndicator(C.root,!1),c.init((e=>o[0]?o[0][e]:void 0)),u.init((e=>o[1]?o[1][e]:void 0)));const h=n/r*100;w.update(h,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function x(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??Le(t,i)}),s.setUpdateIndicator(C.root,!0));const p=o.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&C?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===C?.getOptions()?.look?.title&&(o.events.fireCustomEvent(U,{}),p.unsubscribe(),n?.(),w.close())})),g=new Promise((async(e,o)=>{try{n=e;const o=[];for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,s=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[s]:r[e],...m.preprocessingFuncArgs[e]??{}});o.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};o.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}e(await q(o.map((e=>e.entries)),i,r,c,h,m,f[l.vb]?void 0:S))}catch(e){o(e)}})),y=await g;return w.close(),p.unsubscribe(),y}const E=await x();if(p&&E){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const M=await function(e,t,i,r){return Ie(this,void 0,void 0,(function*(){return new Promise((function(o,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):o(t)}}))}))}(E[0],E[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init((e=>M[e].toString())),C&&(C.props.colorColumnName=I)}catch(T){o.shell.error("Clustering embeddings failed"),console.error(T)}finally{_.close()}}if(E){const L=e.columns.byName(A[0]),N=e.columns.byName(A[1]);if(L.init((e=>E[0][e])),N.init((e=>E[1][e])),g)try{const $=g.inputs[0].name,P=g.inputs[1].name;await g.prepare({[$]:L,[P]:N,...y}).call(!0)}catch(R){o.shell.error("Post-processing failed"),console.error(R)}if(C)return s.setUpdateIndicator(C.root,!1),C.helpUrl="/help/compute/sequence-space",C}}catch(O){o.shell.error("Dimensionality reduction failed"),console.error(O),w.close(),C&&s.setUpdateIndicator(C.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await w();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await w();t(e)}}catch(e){n(e)}}))}(e,[t],i,[r],[1],[u],"MANHATTAN",c,d??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[l.vb],tableView:m})}async function yr(e,t,n){const i=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const i=(await Bi()).getMonomerLib();await(0,di.V)(e,t,n,i)}finally{i.close()}}function br(){(0,Kn.D)().catch((e=>{const[t,n]=(0,we.AP)(e);if(e instanceof qn.Ap)return o.shell.warning(e.element),void Di.logger.warning(t);o.shell.error(t),Di.logger.error(t,void 0,n)}))}async function vr(e=null,t=null){return(0,Kn.D)({col:e,clustersCol:t})}async function wr(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(fe.GO.forColumn(e),!0))),n=async t=>{if(!(0,zn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>fe.GO.forColumn(e).isMsa())),r=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Cr(e){return new ge.m(e).importFasta()}function Ar(e){return console.log(e),[]}function Sr(){const e=(0,Re.m)()[0];(0,Ot.C)(e)}function xr(){return new ni}async function Er(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const t=await o.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${e}`,s}async function _r(e,t){await(0,Jn.k)(e,t)}function Mr(e){const t=fe.GO.forColumn(e).stats;return Object.keys(t.freq)}function Ir(){return new Nt}function Tr(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function Lr(){return new $t}function Nr(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function $r(e){const t=(0,Re.m)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new wt.a7(t)}function Pr(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}async function Rr(e,t,n){return Fi(e,t,n,pe.IDENTITY)}async function Or(e,t,n){return Fi(e,t,n,pe.SIMILARITY)}async function kr(){Ln()}async function Gr(){await async function(){await Rn.showView()}()}function Fr(){(0,kt.TE)()}function Dr(){return new Gt._i}async function Br(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Zn(e,"webLogoLargeApp"),n=await Di.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function Hr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Zn(e,"webLogoAggApp"),n=await Di.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function Vr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new ui(e,"getRegionApp");await t.init()}finally{e.close()}}async function jr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await Di.files.readCsv("samples/HELM_empty_vals.csv"),n=new ui(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function Ur(){const e=a.DataFrame.fromColumns((0,Ne.dW)());o.shell.addTableView(e)}function Wr(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(me.Hi.FASTA)]);o.shell.addTableView(e)}function Yr(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(me.Hi.HELM)]);o.shell.addTableView(e)}function zr(e,t){!function(e,t){const n=fe.GO.forColumn(e.column),i=Object.values(me.Hi).filter((e=>e!==n.units));t.group("Copy").items(i,(t=>{const n=e.column,i=e.rowIndex,r=fe.GO.forColumn(n),s=t===me.Hi.SEPARATOR?Di.properties.defaultSeparator:void 0,a=r.getJoiner({notation:t,separator:s})(r.getSplitted(i));navigator.clipboard?(navigator.clipboard.writeText(a),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t)}async function qr(){await async function(){let e,t;try{const n=new Gn("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity",!1,{autoStartFirstStep:!0});await n.step("Load DNA sequences",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,t=await Di.files.readCsv(Dn),e=o.shell.addTableView(t),e.grid.columns.byName("cluster").visible=!1,e.grid.columns.byName("sequence_id").visible=!1,e.grid.columns.byName("sequence").width=300,e.grid.columns.byName("activity").visible=!1,e.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const t=new Nt(!0);e.addViewer(t,{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"}),e.dockManager.dock(t,a.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await t.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});e.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{t.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{t.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Kr(){await async function(){let e,t,n,i,r;try{const s=new Gn("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results",!1,{autoStartFirstStep:!0});await s.step("Load DNA sequences",(async()=>{[i,e,t]=await Promise.all([Di.files.readCsv(Vn),Bn(),Hn()]),n=o.shell.addTableView(i),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(e,t,n){let i;{const e=Object.values(On);for(let n=0;n<e.length;n++){const i=e[n];if(!t.col(i)){const r=n==e.length-1;t.columns.add(a.Column.float(i,t.rowCount),r)}}if(t.rowCount>=1){const i=t.getCol(n).toList(),r=Date.now();Di.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const o=await q([i],"UMAP",[vt.xL.Levenshtein],[1],"MANHATTAN",{distanceFnArgs:[{}]}),s=Date.now();Di.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(s-r)/1e3} s`);for(let n=0;n<e.length;n++){const i=e[n],r=t.getCol(i),s=o[n];r.init((e=>s[e]))}const a=Date.now();Di.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-s)/1e3} s`)}i=await t.plot.fromType(a.VIEWER.SCATTER_PLOT,{xColumnName:On.X,yColumnName:On.Y,lassoTool:!0})}return e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(n,i,jn),r.setOptions({color:"activity"})}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const r=await e.calcDistanceMatrix(i,[jn]),o=await xe(r.data,i.rowCount,1),s=e.parseClusterMatrix(o);t.injectTreeForGrid(n.grid,s,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.set(65,!0)}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{[67,72,77,82,83,84,85,91,93].forEach((e=>i.selection.set(e,!0))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Zr(){await async function(){let e,t,n,i,r;const s=c.c.UMAP;try{const l=new Gn("Activity Cliffs","Activity Cliffs analysis on Macromolecules data",!1,{autoStartFirstStep:!0});await l.step("Load DNA sequences",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,[n,e,t]=await Promise.all([Di.files.readCsv(Un),Bn(),Hn()]),i=o.shell.addTableView(n),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{const e=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];r=await pr(n,n.getCol("Sequence"),n.getCol("Activity"),80,s,yt.Z.LEVENSHTEIN,e,{},!0),i.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),on()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const r=a.TaskBarProgressIndicator.create("Running sequence clustering..."),o=await e.calcDistanceMatrix(n,["sequence"]),s=await xe(o.data,n.rowCount,1),l=e.parseClusterMatrix(s);r.close(),t.injectTreeForGrid(i.grid,l,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const e=r.dataFrame.temp[".cliffsDfGrid"];e.dataFrame.rowCount>0&&(e.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Xr(){await async function(){const e="HELM";let t,n,i;try{await new Gn("Atomic Level","Atomic level structure of Macromolecules",!1,{autoStartFirstStep:!0}).step("Loading Macromolecules notation 'Helm'",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,t=await Di.files.readCsv("samples/HELM.csv"),n=o.shell.addTableView(t);for(let t=0;t<n.grid.columns.length;t++){const i=n.grid.columns.byIndex(t);[e,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=t.getCol(e);await yr(t,n,!1)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${e})`;t.currentCell=t.cell(1,n);const r=t.currentCell.value,o=new a.chem.Sketcher(a.chem.SKETCHER_MODE.INPLACE);o.setMolFile(r),i=s.dialog().add(o).show(),await(0,st.cb)(3e3),i.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Jr(){await async function(){let e,t,n,i,r,s;const l="msa(HELM)",h=c.c.UMAP,d=(await Wn.Nk.getDockerContainer()).id,p=Wn.Nk.getDockerContainer();let m,f;try{const c=new Gn("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data",!1,{autoStartFirstStep:!0});await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{[m,t]=await Promise.all([(async()=>(await p).status)(),Di.files.readCsv(Yn)]),e=o.shell.addTableView(t),o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,"started"===m||"checking"===m?(Di.logger.debug(`demoBio05UI(), PepSeA ('${Wn.Nk.dcName}') docker container status = '${m}'.`),f=Promise.resolve()):(Di.logger.warning(`demoBio05UI(), PepSeA ('${Wn.Nk.dcName}') docker container is trying to start...`),await o.dapi.docker.dockerContainers.run(d),f=async function(e,t,n=3e4,i){const r=window.performance.now(),s=new u.Subject,a=async()=>{const n=await o.dapi.docker.dockerContainers.find(e);return n.status===t&&s.next(n),n};let l;try{await(0,st.PE)(s,(e=>{const n=window.performance.now();i.debug(`awaitStatus(), docker container ('${e.name}') GET status = '${t}' in ${n-r} ms.`)}),(async()=>{const e=await a();i.debug(`awaitStatus(), docker container ('${e.name}') HAS status = '${e.status}'.`),l=window.setInterval(a,200)}),n)}finally{window.clearInterval(l)}}(d,"started",3e4,Di.logger))}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{const e=a.TaskBarProgressIndicator.create("MSA by PepSeA ...");try{await f,n=t.getCol("HELM");const e=Wn.ZY[0],r=1.53,s=0;if(i=await(0,Wn.GD)(n,l,e,r,s,void 0),!i)throw new Error("Empty MSA result.");t.columns.add(i),await o.data.detectSemanticTypes(t)}finally{e.close()}}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{const n=a.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];s=await gr(t,i,h,yt.Z.LEVENSHTEIN,!0,n,void 0,void 0,!0),e.dockManager.dock(s,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await t.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Qr(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}async function eo(e,t,n){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,st.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}async function to(){return Gi.getInstance()}function no(e,t,n){return async function(e,t,n=!0){const i=(await Gi.getInstance()).getHelmToMolfileConverter(e,t).convertToRdKitBeautifiedMolfileColumn(n,Di.rdKitModule);return i.semType=a.SEMTYPE.MOLECULE,i}(e,t,n)}function io(e,t){e.temp[fe.j8.notationProvider]=new pi(t)}function ro(e,t){e.temp[fe.j8.notationProvider]=new fi(t)}},6625:(e,t,n)=>{"use strict";n.d(t,{$:()=>o});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class o{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const s=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>e&&(e=this.dpGrid[i][r].value,t=i,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}},8115:(e,t,n)=>{"use strict";n.d(t,{BQ:()=>m,a7:()=>h,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(1407),a=n(4870),l=n(8070),c=n(2003);const u="substr_helm";class h{units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e){this.col=e[0],this.createUI()}editHelmLinkAction(){(0,a.K)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(u,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===c.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===c.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,a.K)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(c.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=o.DataFrame.create(1);t.columns.addNewString(u).init((e=>"")),t.col(u).semType=this.col.semType,t.col(u).meta.units=c.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(c.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===c.Hi.HELM?t.get(u,0):this.substructureInput.value;this.units===c.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===c.Hi.HELM?await p(n,this.col):d(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,r=e.charAt(e.length-1)===t,o=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(e,n):e,r=o.BitSet.create(t.length);for(let n=0;n<t.length;n++){const o=t.get(n);(o.match(i)||o===e)&&r.set(n,!0,!1)}return r}async function p(e,t){t.version!==t.temp["last-invalidated-version"]&&await m(t,!0);const n=o.Column.string("helm",1).init((t=>e));n.semType=o.SEMTYPE.MACROMOLECULE,n.meta.units=c.Hi.HELM;const r=await(0,s.R)(n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:r.get(0),molBlockFailover:""})).get(0)}async function m(e,t){const n=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,l.cb)(10);const n=new Map,i=await(0,s.R)(e,t,n);e.temp["monomeric-mols"]=i,e.temp["monomers-dict"]=n,e.temp["last-invalidated-version"]=e.version}finally{n.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>s});var i=n(4328),r=n(6082),o=n(826);function s(e,t,n=[],s=[],a=!0){const[l,c]=function(e,t,n=[],s=[]){let a=!0,l="";const c=o.GO.forColumn(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(e,t,n,s);return a&&!l&&i.shell.warning(c),l}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>u,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(8152);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{C:()=>d});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(826);let u=null,h=[];function d(e){let t=e??o.shell.t.columns.bySemType("Macromolecule");if(!t)throw new Error("No column with Macromolecule semantic type found");let n=c.GO.forColumn(t),s=n.notation;const d=r.divText("Current notation: "+s,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:t,onValueChanged:e=>{var o;(o=e).semType===i.SEMTYPE.MACROMOLECULE?(t=o,n=c.GO.forColumn(t),s=n.notation,s===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+s,g=p.filter((e=>e!==s)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),u?.clear(),u?.add(r.div([d,m.root,v.root,y.root]))):m.value=t}}),f=["-",".","/"];let g=p.filter((e=>e!==s));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==u&&(u=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const e=v.value,n=e===l.Hi.SEPARATOR?y.value:void 0;await async function(e,t,n){const i=c.GO.forColumn(e).convert(t,n);e.dataFrame.columns.add(i);const r=await o.functions.call("Bio:detectMacromolecule",{col:i});return r&&(i.semType=r),await o.data.detectSemanticTypes(e.dataFrame),i}(t,e,n)})).show({x:350,y:100}),h.push(u.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],u=null}))))}},6740:(e,t,n)=>{"use strict";n.d(t,{m8:()=>s});var i=n(4328),r=n(8070),o=n(8152);async function s(e=6e4){const t=await o.Nk.getDockerContainer();await async function(e,t=6e4){let n=e,o=!1;for(let s=0;s<t/200;++s){if(null===n&&(n=await i.dapi.docker.dockerContainers.find(e.id)),a(n)){o=!0;break}switch(n.status){case"stopped":await i.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,r.cb)(200)}if(!o)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>s});var i=n(6956);class r{constructor(e){const t=e.split(i.xe);t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const r=i[t],o=e.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),e.push(n)})),e}}class o{simplePolymer;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach((e=>{n.push(e),i.push("Backbone")})),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],r=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],r=i-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class s{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(i.pk),n=t[0].split(i.xe);this.simplePolymers=n.map((e=>new o(e))),""!==t[1]&&(this.connectionList=new r(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,i),t.push(...i)})),this.connectionList&&this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,i.push(r)})),t.push(i)})),t}}},1054:(e,t,n)=>{"use strict";n.d(t,{v:()=>i});class i{molfile;monomers;constructor(e,t){this.molfile=e,this.monomers=t}static empty(){return new i("",[])}}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>T});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(826),c=n(608),u=n(8152),h=n(966),d=n(4139),p=n(6740),m=n(567),f=n(5072),g=n.n(f),y=n(7825),b=n.n(y),v=n(7659),w=n.n(v),C=n(5056),A=n.n(C),S=n(540),x=n.n(S),E=n(1113),_=n.n(E),M=n(6369),I={};async function T(e={}){return new Promise((async(t,n)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=d.HX.pepsea.method,e.pepsea.gapOpen??=d.HX.pepsea.gapOpen,e.pepsea.gapExtend??=d.HX.pepsea.gapExtend;const a=e.col?.dataFrame??i.shell.t,l=e.col??a.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==l){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(e),void n(new c.Ap(o.divText(e)))}const h=o.input.choice("Method",{value:e.pepsea.method,items:u.ZY});h.setTooltip("Alignment method");const p=o.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const m=o.p(`Kalign version: ${d.b9}`,"kalign-version"),f=o.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const g=o.input.float("Gap extend",{value:e.pepsea.gapExtend});g.setTooltip("Gap extension penalty to skip the alignment");const y=o.inputs([f,g,p]),b=o.button("Alignment parameters",(()=>{y.hidden=!y.hidden,[f,g,p].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");b.classList.add("msa-params-button"),y.hidden=!0,b.prepend(o.icons.settings((()=>null)));const v=[h.root.style],w=[p.root.style,m.style];let C,A=l;const S=o.input.column("Sequence",{table:a,value:l,onValueChanged:async e=>{if(!e||e.semType!==r.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,s.cb)(0),void(S.value=A);A=e,_.disabled=!1,C=await N(S.value,a,v,w,h,x,f,g,p)},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE});S.setTooltip("Sequences column to use for alignment");const x=o.input.column("Clusters",{table:a,value:e.clustersCol});x.nullable=!0;const E=o.dialog("MSA").add(S).add(x).add(h).add(y).add(b).add(m).onOK((async()=>{await L(S,a,C,t,n)})),_=E.getButton("OK");if(S.fireChanged(),e.col)return C=await N(e.col,a,v,w,h,x,f,g,p),void await L(S,a,C,t,n);E.show()}))}async function L(e,t,n,o,s){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");t.columns.add(a),await i.data.detectSemanticTypes(t),o(a)}catch(e){s(e)}finally{l.close()}}async function N(e,t,n,o,s,f,g,y,b){try{if(e.semType!==r.SEMTYPE.MACROMOLECULE)return;const i=t.columns.getUnusedName(`msa(${e.name})`);if((0,h.V)(e,e.name,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT],!1)){$(n,o,"kalign"),g.value=null,y.value=null,b.value=null;const t=l.GO.forColumn(e),r=t.isFasta()?e:t.convert(a.Hi.FASTA);return async()=>await(0,c.eE)(r,!1,i,f.value)}if((0,h.V)(e,e.name,[a.Hi.HELM],[],!1))return $(n,o,"pepsea"),g.value??=d.HX.pepsea.gapOpen,y.value??=d.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(e,i,s.value,g.value,y.value,f.value));if((0,h.V)(e,e.name,[a.Hi.SEPARATOR],[a.YI.UN],!1)){const t=l.GO.forColumn(e).convert(a.Hi.HELM);return $(n,o,"pepsea"),g.value??=d.HX.pepsea.gapOpen,y.value??=d.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(t,i,s.value,g.value,y.value,f.value))}return g.value=null,y.value=null,b.value=null,void $(n,o,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),m._package.logger.error(t)}}function $(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}I.styleTagTransform=_(),I.setAttributes=A(),I.insert=w().bind(null,"head"),I.domAPI=b(),I.insertStyleElement=x(),g()(M.A,I),M.A&&M.A.locals&&M.A.locals},608:(e,t,n)=>{"use strict";n.d(t,{Ap:()=>G,aZ:()=>H,eE:()=>D});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=e=>"object"==typeof e&&null!==e||"function"==typeof e,m=new Map([["proxy",{canHandle:e=>p(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>p(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:r,type:o,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const t=s.slice(0,-1).reduce(((e,t)=>e[t]),e),n=s.reduce(((e,t)=>e[t]),e);switch(o){case"GET":l=n;break;case"SET":t[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch((e=>({value:e,[d]:0}))).then((e=>{const[i,s]=S(e);t.postMessage(Object.assign(Object.assign({},i),{id:r}),s),"RELEASE"===o&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let i=!1;const r=new Proxy(n,{get(n,o){if(b(i),o===h)return()=>E(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),i=!0}));if("then"===o){if(0===t.length)return{then:()=>r};const n=E(e,{type:"GET",path:t.map((e=>e.toString()))}).then(x);return n.then.bind(n)}return v(e,[...t,o])},set(n,r,o){b(i);const[s,a]=S(o);return E(e,{type:"SET",path:[...t,r].map((e=>e.toString())),value:s},a).then(x)},apply(n,r,o){b(i);const s=t[t.length-1];if(s===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(e,t.slice(0,-1));const[a,l]=C(o);return E(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},l).then(x)},construct(n,r){b(i);const[o,s]=C(r);return E(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:o},s).then(x)}});return r}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map((e=>e[0])),w(t.map((e=>e[1])))]}const A=new WeakMap;function S(e){for(const[t,n]of m)if(n.canHandle(e)){const[i,r]=n.serialize(e);return[{type:"HANDLER",name:t,value:i},r]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return m.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise((i=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==r||(e.removeEventListener("message",t),i(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:r},t),n)}))}const _="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{e.stdout+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{stdout:i}})},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";e[s]+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{[s]:i}})}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",M=typeof window<"u"&&window.Blob&&new Blob([atob(_)],{type:"text/javascript;charset=utf-8"});function I(){const e=M&&(window.URL||window.webkitURL).createObjectURL(M);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+_)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},T,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new I;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class ${static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}$.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class P{constructor(e="categorial"){this.aa2num=$.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const i=["NH2","COOH"];if(e.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${i[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(i[1])){const t=i[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${i[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return P._dropDefises(P._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let i=0;i<t;++i){const t=e[i];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[i]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const i=e[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${e}'`),t+=this.num2aa[i]}return t}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function F(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function D(e,t=!1,n="",i=null,o,s,c){let u=e.toList();t&&(u=u.map((e=>P.clean(e).replace(/\-/g,""))));const h=e.length;i??=r.Column.string("Clusters",h).init("0"),i.type!=r.COLUMN_TYPE.STRING&&(i=i.convertTo(r.TYPE.STRING)),i.compact();const d=i.categories,p=i.getRawData(),m=new Array(d.length),f=new Array(d.length);for(let e=0;e<h;++e){const t=p[e];(m[t]??=[]).push(u[e]),(f[t]??=[]).push(e)}H(f,d);const g=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=r.Column.string(n,h);for(let e=0;e<d.length;++e){const t=F(m[e]);await g.fs.writeFile(O,t);const n=`${void 0!==o?` --gpo ${o}`:""}${void 0!==s?` --gpe ${s}`:""}${void 0!==c?` --tgpe ${c}`:""}`,i=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(i);const r=await g.cat(k);if(!r){const e=B(i,1);throw new Error(e)}const l=new a.m(r).sequencesArray,u=f[e];for(let e=0;e<l.length;++e)y.set(u[e],l[e])}const b=e.meta.units,v=e.getTag(l.gp.alphabet);return y.meta.units=b,y.setTag(l.gp.aligned,"SEQ.MSA"),y.setTag(l.gp.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=i.exec(e))&&(void 0===t||n.length<t);)n.push(r[1]);return n.join("\n")}function H(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((e=>{let r=t[e];return r.length>25&&(r=r.slice(0,25)+"..."),i.divText(`"${r}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new G(e)}}},8152:(e,t,n)=>{"use strict";n.d(t,{GD:()=>d,Nk:()=>c,ZY:()=>u});var i=n(4328),r=n(6082),o=n(2003),s=n(608),a=n(4139),l=n(567);const c=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n="ginsi",i=1.53,l=0,u=null,d){const m=await c.getDockerContainer();if("started"!==m.status&&"checking"!==m.status)throw new Error("PepSeA container has not started yet");const f=e.length;u??=r.Column.int("Clusters",f).init(0),u.type!=r.COLUMN_TYPE.STRING&&(u=u.convertTo(r.TYPE.STRING));const g=u.categories,y=u.getRawData(),b=new Array(g.length),v=new Array(g.length);for(let t=0;t<f;++t){const n=y[t],i=g[n];if(""===i)continue;const r=g.indexOf(i),o=e.get(t);o&&((b[r]??=[]).push({ID:t.toString(),HELM:o}),(v[n]??=[]).push(t))}(0,s.aZ)(v,g);const w=new Array(f);for(const e of b){const t=(await p(m.id,e,n,i,l,d)).Alignment;for(const e of t)w[parseInt(e.ID)]=Object.entries(e).filter((e=>!h.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.J.SEPARATOR)}const C=r.Column.fromStrings(t,w);return C.meta.units=o.Hi.SEPARATOR,C.setTag(o.gp.separator,a.J.SEPARATOR),C.setTag(o.gp.aligned,"SEQ.MSA"),C.setTag(o.gp.alphabet,o.YI.UN),C.setTag(o.gp.alphabetIsMultichar,"true"),C.semType=r.SEMTYPE.MACROMOLECULE,C}async function p(e,t,n,r,o,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${r}&gap_extend=${o}`;let u;if("fetchProxy"in i.dapi.docker.dockerContainers){const t=window.performance.now(),n=await i.dapi.docker.dockerContainers.fetchProxy(e,c,a),r=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${r-t} ms`);const o="application/json"===n.headers.get("content-type");if(!n.ok&&o){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const i=e["datagrok-error"];if(i)throw new Error(`Datagrok error: ${i}`);throw new Error(n.statusText)}if(!n.ok&&!o){const e=await n.text();throw new Error(`Error: ${e}`)}if(!o){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await i.dapi.docker.dockerContainers.request(e,c,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const r=u["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];s?.warning(e)}return u}},3890:(e,t,n)=>{"use strict";n.d(t,{TE:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1991),a=n.n(s),l=n(826);const c=60;function u(){const e=o.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],u=r.input.multiChoice("Seq id columns",{value:s,items:t.map((e=>e.name))}),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const t=e.column;return!(!t||t.semType!==i.SEMTYPE.MACROMOLECULE)&&l.GO.forColumn(t).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=r.input.choice("Seq column",{value:p,items:d.map((e=>e.name))}),f=r.input.int("FASTA line width",{value:c});r.dialog({title:"Save as FASTA"}).add(r.inputs([u,m,f])).onOK((()=>{const t=u.value?u.value.map((t=>e.columns.byName(t).column)):[],n=m.value?e.columns.byName(m.value).column:null,i=f.value??c;n||o.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(e,t,n=c,i="\n"){const r=l.GO.forColumn(t),o=[];for(let s=0;s<t.length;s++){const t=e.map((e=>e.get(s).toString())).join("|"),a=h(r.getSplitted(s),n);o.push(`>${t}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,n,i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()})).show()}function h(e,t=c){let n=0;const i=e.length,r=[];for(;n<i;){const i=a()(e.originals).slice(n,n+t).toArray(),o=i.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");r.push(o),n+=i.length}return r}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var i=n(4328),r=n(7384),o=n(826),s=n(2003),a=n(6717),l=n(8312),c=n(966);async function u(e,t,n,u){let h;try{h=await(0,a.j)()}catch(e){return i.shell.warning('Transformation to atomic level requires package "Chem" installed.'),null}let d=null;if(n){const n=await(0,l.Q)(),i=o.GO.forColumn(t);let r,a,c;i.isHelm()?a=t:(c=t.name,t.name=`__${c}`,a=i.convert(s.Hi.HELM),a.name=c,e.columns.add(a,!1));try{r=await n.helmToAtomicLevel(a,!0,!0)}finally{a!==t&&(e.columns.remove(a.name),t.name=c)}e.columns.add(r.molCol),e.columns.add(r.molHighlightCol),d=r.molCol}else{if(!(0,c.V)(t,"To Atomic Level"))return null;const n=await(0,r.C4)(e,t,u);null!==n.col&&(e.columns.add(n.col,!0),d=n.col)}return d&&await i.data.detectSemanticTypes(e),d}},5785:(e,t,n)=>{"use strict";n.d(t,{k:()=>u});var i=n(4328),r=n(6082),o=n(8070),s=n(966),a=n(3077),l=n(4139),c=n(439);async function u(e,t){if(await(0,o.cb)(10),!(0,s.V)(t,"Sequence space"))return e;const n=(0,a.R)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=l.uF.MONOMER,e.setTag(c.gp.alphabet,t.getTag(c.gp.alphabet));const h=/(\d+)(?: \((\d+)\))?/,d=e=>{h.lastIndex=0;const t=e.match(h);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const i=n.columns.byIndex(e);i.semType=l.uF.MONOMER,i.setTag(c.gp.alphabet,t.getTag(c.gp.alphabet));const r=100;let o=0;for(;u.columns.byName(i.name)&&o<r;)i.name=d(i.name),o++;u.columns.add(i)}await i.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(r.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4870:(e,t,n)=>{"use strict";n.d(t,{K:()=>s,m:()=>o});var i=n(4328),r=n(6082);function o(){const e=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);if(null!==e)return e;i.shell.error("Current table does not contain macromolecules")}function s(e,t){e.innerHTML="",e.append(t)}},8047:(e,t,n)=>{"use strict";n.d(t,{n5:()=>v,oP:()=>M});var i=n(4328),r=n(7389),o=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(826),d=n(2003),p=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var f=n(2738),g=n(8070),y=n(7602);var b,v,w=n(2174),C=n(567);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new o.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},o.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class A{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?o.Column.fromFloat32Array(n,e):e instanceof Int32Array?o.Column.fromInt32Array(n,e):o.Column.fromList(o.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===p.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===p.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,r,s,a,l,c){const u=i===p.fH.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let h=c*l+(n-u-1);const d=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1));for(const[n,i]of d){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,r){for(const[o,s]of Object.entries(this._freqs))if(o!==f._S){const a=(0,d.zS)(o,5),l=s.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=r.get(o)??r.get("other"),e.textAlign="left",e.font=t;const u=e.measureText(a);e.setTransform(l.width/u.width,0,0,l.height/i,c,l.top),e.fillText(a,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w.F)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(v||(v={}));const x=p.Fo;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const _=new class{render=20};class M extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHandler;initialized=!1;palette=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===p.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===p.mH.ON?this.positionMargin:0}constructor(){super(),this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA});const e=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],t=Object.values(o.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(p.fH)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(p.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(p.P4)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(p.mH)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(p.lT)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.g(C._package.logger)}static viewerCounter=-1;viewerId=++M.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=h.GO.forColumn(this.seqCol),this.palette=(0,d.SM)(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case p.lT.Filtered:e=this.dataFrame.filter;break;case p.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=p.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===p.Lp.TOP?"start":this.verticalAlignment===p.Lp.MIDDLE?"center":this.verticalAlignment===p.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const r=t>i;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===p.Lp.TOP?"start":this.verticalAlignment===p.Lp.MIDDLE?"center":this.verticalAlignment===p.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,e.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(d.gp.positionNames),t=this.seqCol.getTag(d.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(d.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(d.z1).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(d.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=h.GO.forColumn(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}const l=this.dataFrame.rowCount;for(let e=0;e<s;++e){for(let t=0;t<l;++t)if(i.get(t)){const n=this.seqHandler.getSplitted(t),i=e<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?f._S:i,o=this.positions[e],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(let n=0;n<l;++n)if(i.get(n)){const i=this.seqHandler.getSplitted(n).getCanonical(this.startPosition+e),r=t.get(n);this.positions[e].getFreq(i).push(r)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==p.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=o.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,r,o,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=o[t],i=e.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],h=(l-s)*n*t+i*t/2,d=(r*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=s;e++)this.positions[e].render(a,i,l,c,this.palette)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;getAlphabetSize(){return this.seqHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===p.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===p.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[r.divText(`Position ${s.label}`)];this.valueAggrType===o.AGG.TOTAL_COUNT&&e.push(s.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=r.divV(t);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,r,o){const s=t.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>s,n:()=>o});var i=n(1858),r=n(567);class o{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class s{onChanged=new i.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>E});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(826),d=n(7602),p=n(8115),m=n(4577),f=n(1757),g=n.n(f),y=n(9124),b=n(9192),v=n(4870),w=n(567);class C extends m.O{emptyProps=new m.n("");helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++C.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,y.b)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,b.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,b.AP)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,v.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,v.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class x extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class E extends r.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new d.g(this.logger=w._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++E.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),h.GO.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new _:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new C,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;w._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(A,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(w._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{w._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),w._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,w._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;w._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new x("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new x(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new x(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new x("")}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,p.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>_,j:()=>E});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(4152),c=n(5072),u=n.n(c),h=n(7825),d=n.n(h),p=n(7659),m=n.n(p),f=n(5056),g=n.n(f),y=n(540),b=n.n(y),v=n(1113),w=n.n(v),C=n(5999),A={};A.styleTagTransform=w(),A.setAttributes=g(),A.insert=m().bind(null,"head"),A.domAPI=d(),A.insertStyleElement=b(),u()(C.A,A),C.A&&C.A.locals&&C.A.locals;var S=n(826),x=n(2738);function E(e){const t=i.div();t.classList.add("macromolecule-cell-comp-analysis-host");const n=e.cell.column.tags[a.gp.alphabet];let o=l.oT.Color;switch(n){case a.YI.DNA:case a.YI.RNA:o=(0,a.ny)(a.YI.DNA);break;case a.YI.PT:o=(0,a.ny)(a.YI.PT)}const c={},u=S.GO.forColumn(e.cell.column),h=e.cell.rowIndex,d=u.getSplitted(h);s()(d.canonicals).filter((e=>e!==x._S)).forEach((e=>{const t=c[e]||0;c[e]=t+1}));const p=_(o,c);return Array.from(p.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),t.appendChild(p),new r.Widget(t)}function _(e,t){let n=0,o=null;for(const e of Object.values(t))n+=e,o=null===o?e:Math.max(o,e);const s=o/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,o])=>{const a=o/n,l=e.get(t),c=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});c.style.width=50*a/s+"px",c.style.backgroundColor=l,x._S===t&&(c.style.borderWidth="1px",c.style.borderStyle="solid",c.style.borderColor=r.Color.toHtml(r.Color.lightGray));const u=x._S===t?"-":t,h=i.div(`${(100*a).toFixed(2)}%`),d=i.div([c,h],{classes:"macromolecule-cell-comp-analysis-value"});return{[u]:d}}))),l=i.tableFromMap(a);return Array.from(l.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),l}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:r,removeDotSegments:o,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const r={};return i||(e=p(u(e,n),n),t=p(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(r.scheme=t.scheme,r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(t.path?("/"===t.path.charAt(0)?r.path=o(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?r.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:r.path=t.path:r.path="/"+t.path,r.path=o(r.path)),r.query=t.query):(r.path=e.path,void 0!==t.query?r.query=t.query:r.query=e.query),r.userinfo=e.userinfo,r.host=e.host,r.port=e.port),r.scheme=e.scheme),r.fragment=t.fragment,r}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),r=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&(r.push(n.scheme),r.push(":"));const c=s(n,i);if(void 0!==c&&("suffix"!==i.reference&&r.push("//"),r.push(c),n.path&&"/"!==n.path.charAt(0)&&r.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=o(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),r.push(e)}return void 0!==n.query&&(r.push("?"),r.push(n.query)),void 0!==n.fragment&&(r.push("#"),r.push(n.fragment)),r.join("")}const h=Array.from({length:127},((e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(e,t){const n=Object.assign({},t),o={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(o.scheme=c[1],o.userinfo=c[3],o.host=c[4],o.port=parseInt(c[5],10),o.path=c[6]||"",o.query=c[7],o.fragment=c[8],isNaN(o.port)&&(o.port=c[5]),o.host){const e=r(o.host);if(!1===e.isIPV4){const t=i(e.host,{isIPV4:!1});o.host=t.host.toLowerCase(),a=t.isIPV6}else o.host=e.host,a=!0}void 0!==o.scheme||void 0!==o.userinfo||void 0!==o.host||void 0!==o.port||o.path||void 0!==o.query?void 0===o.scheme?o.reference="relative":void 0===o.fragment?o.reference="absolute":o.reference="uri":o.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==o.reference&&(o.error=o.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||o.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&o.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(o.host))try{o.host=URL.domainToASCII(o.host.toLowerCase())}catch(e){o.error=o.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==o.scheme&&(o.scheme=unescape(o.scheme)),s&&void 0!==o.userinfo&&(o.userinfo=unescape(o.userinfo)),s&&void 0!==o.host&&(o.host=unescape(o.host)),void 0!==o.path&&o.path.length&&(o.path=escape(unescape(o.path))),void 0!==o.fragment&&o.fragment.length&&(o.fragment=encodeURI(decodeURIComponent(o.fragment)))),e&&e.parse&&e.parse(o,n)}else o.error=o.error||"URI can not be parsed.";return o}const m={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(p(e,i),p(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function r(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function o(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:r,serialize:o},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:r,serialize:o},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const r=`${n}:${t.nid||e.nid}`,o=l[r];e.path=void 0,o&&(e=o.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),r=`${n}:${t.nid||i}`,o=l[r];o&&(e=o.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914:e=>{"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(e,t,n)=>{"use strict";const{HEX:i}=n(4914);function r(e){if(l(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(/^(?:(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])\.){3}(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])$/u)||[],[n]=t;return n?{host:a(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function o(e,t=!1){let n="",r=!0;for(const t of e){if(void 0===i[t])return;"0"!==t&&!0===r&&(r=!1),r||(n+=t)}return t&&0===n.length&&(n="0"),n}function s(e,t={}){if(l(e,":")<2)return{host:e,isIPV6:!1};const n=function(e){let t=0;const n={error:!1,address:"",zone:""},i=[],r=[];let s=!1,a=!1,l=!1;function c(){if(r.length){if(!1===s){const e=o(r);if(void 0===e)return n.error=!0,!1;i.push(e)}r.length=0}return!0}for(let o=0;o<e.length;o++){const u=e[o];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!c())break;s=!0}else r.push(u);else{if(!0===a&&(l=!0),!c())break;if(t++,i.push(":"),t>7){n.error=!0;break}o-1>=0&&":"===e[o-1]&&(a=!0)}}return r.length&&(s?n.zone=r.join(""):l?i.push(r.join("")):i.push(o(r))),n.address=i.join(""),n}(e);if(n.error)return{host:e,isIPV6:!1};{let e=n.address,t=n.address;return n.zone&&(e+="%"+n.zone,t+="%25"+n.zone),{host:e,escapedHost:t,isIPV6:!0}}}function a(e,t){let n="",i=!0;const r=e.length;for(let o=0;o<r;o++){const s=e[o];"0"===s&&i?(o+1<=r&&e[o+1]===t||o+1===r)&&(n+=s,i=!1):(i=s===t,n+=s)}return n}function l(e,t){let n=0;for(let i=0;i<e.length;i++)e[i]===t&&n++;return n}const c=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,h=/^\/\.\.(?:\/|$)/u,d=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e,t){const n=[];if(void 0!==e.userinfo&&(n.push(e.userinfo),n.push("@")),void 0!==e.host){let t=unescape(e.host);const i=r(t);if(i.isIPV4)t=i.host;else{const n=s(i.host,{isIPV4:!1});t=!0===n.isIPV6?`[${n.escapedHost}]`:e.host}n.push(t)}return"number"!=typeof e.port&&"string"!=typeof e.port||(n.push(":"),n.push(String(e.port))),n.length?n.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(c))e=e.replace(c,"");else if(e.match(u))e=e.replace(u,"/");else if(e.match(h))e=e.replace(h,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(d);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:s,stringArrayToHexStripped:o}},3837:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(i){var r=t[i];if(void 0!==r)return r.exports;var o=t[i]={id:i,loaded:!1,exports:{}};return e[i].call(o.exports,o,o.exports,n),o.loaded=!0,o.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var i in t)n.o(t,i)&&!n.o(e,i)&&Object.defineProperty(e,i,{enumerable:!0,get:t[i]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var i=t.getElementsByTagName("script");if(i.length)for(var r=i.length-1;r>-1&&(!e||!/^http(s?):/.test(e));)e=i[r--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(567);bio=i})();
7
+ deps: ${n}}`};const s={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const i in e)"__proto__"!==i&&((Array.isArray(e[i])?t:n)[i]=e[i]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:r,it:s}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,o.propertyInData)(n,r,l,s.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),s.allErrors?n.if(u,(()=>{for(const t of c)(0,o.checkReportMissingProp)(e,t)})):(n.if(i._`${u} && (${(0,o.checkMissingProp)(e,c,a)})`),(0,o.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:i,keyword:s,it:a}=e,l=n.name("valid");for(const c in t)(0,r.alwaysValidSchema)(a,t[c])||(n.if((0,o.propertyInData)(n,i,c,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:s,schemaProp:c},l);e.mergeValidEvaluated(t,l)}),(()=>n.var(l,!0))),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=s},4845:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,i.validateSchemaDeps)(e)};t.default=r},1239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>i.str`must match "${e.ifClause}" schema`,params:({params:e})=>i._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:o}=e;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(o,'"if" without "then" and "else" is ignored');const a=s(o,"then"),l=s(o,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,i.not)(u),h("else"));function h(n,r){return()=>{const o=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(o,c),r?t.assign(r,i._`${n}`):e.setParams({ifClause:n})}}e.pass(c,(()=>e.error(!0)))}};function s(e,t){const n=e.schema[t];return void 0!==n&&!(0,r.alwaysValidSchema)(e,n)}t.default=o},6378:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5457),r=n(5354),o=n(494),s=n(3966),a=n(2661),l=n(3025),c=n(9713),u=n(8660),h=n(117),d=n(5333),p=n(7923),m=n(6505),f=n(6163),g=n(5844),y=n(1239),b=n(4426);t.default=function(e=!1){const t=[p.default,m.default,f.default,g.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(r.default,s.default):t.push(i.default,o.default),t.push(a.default),t}},494:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const i=n(9029),r=n(4227),o=n(5765),s={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,r.alwaysValidSchema)(n,t)||e.ok((0,o.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:o,parentSchema:s,data:a,keyword:l,it:c}=e;!function(e){const{opts:i,errSchemaPath:o}=c,s=n.length,a=s===e.minItems&&(s===e.maxItems||!1===e[t]);if(i.strictTuples&&!a){const e=`"${l}" is ${s}-tuple, but minItems or maxItems/${t} are not specified or different at path "${o}"`;(0,r.checkStrictMode)(c,e,i.strictTuples)}}(s),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(o,n.length,c.items));const u=o.name("valid"),h=o.const("len",i._`${a}.length`);n.forEach(((t,n)=>{(0,r.alwaysValidSchema)(c,t)||(o.if(i._`${h} > ${n}`,(()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=s},3966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(5765),s=n(5457),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:i}=e,{prefixItems:a}=n;i.items=!0,(0,r.alwaysValidSchema)(i,t)||(a?(0,s.validateAdditionalItems)(e,a):e.ok((0,o.validateArray)(e)))}};t.default=a},7923:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:r}=e;if((0,i.alwaysValidSchema)(r,n))return void e.fail();const o=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},o),e.failResult(o,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=r},6163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>i._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:o,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(s.opts.discriminator&&o.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block((function(){a.forEach(((n,o)=>{let a;(0,r.alwaysValidSchema)(s,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:o,compositeRule:!0},u),o>0&&t.if(i._`${u} && ${l}`).assign(l,!1).assign(c,i._`[${c}, ${o}]`).else(),t.if(u,(()=>{t.assign(l,!0),t.assign(c,o),a&&e.mergeEvaluated(a,i.Name)}))}))})),e.result(l,(()=>e.reset()),(()=>e.error(!0)))}};t.default=o},5333:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s=n(4227),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,i.allSchemaProperties)(n),d=h.filter((e=>(0,o.alwaysValidSchema)(c,n[e])));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const p=u.strictSchema&&!u.allowMatchingProperties&&l.properties,m=t.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,s.evaluatedPropsToName)(t,c.props));const{props:f}=c;function g(e){for(const t in p)new RegExp(e).test(t)&&(0,o.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(o=>{t.if(r._`${(0,i.usePattern)(e,n)}.test(${o})`,(()=>{const i=d.includes(n);i||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:o,dataPropType:s.Type.Str},m),c.opts.unevaluated&&!0!==f?t.assign(r._`${f}[${o}]`,!0):i||c.allErrors||t.if((0,r.not)(m),(()=>t.break()))}))}))}!function(){for(const e of h)p&&g(e),c.allErrors?y(e):(t.var(m,!0),y(e),t.if(m))}()}};t.default=a},5354:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(494),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,i.validateTuple)(e,"items")};t.default=r},117:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2586),r=n(5765),o=n(4227),s=n(8660),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&s.default.code(new i.KeywordCxt(c,s.default,"additionalProperties"));const u=(0,r.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=o.mergeEvaluated.props(t,(0,o.toHash)(u),c.props));const h=u.filter((e=>!(0,o.alwaysValidSchema)(c,n[e])));if(0===h.length)return;const d=t.name("valid");for(const n of h)p(n)?m(n):(t.if((0,r.propertyInData)(t,l,n,c.opts.ownProperties)),m(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function p(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function m(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},9713:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>i._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:o,it:s}=e;if((0,r.alwaysValidSchema)(s,n))return;const a=t.name("valid");t.forIn("key",o,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,i.not)(a),(()=>{e.error(!0),s.allErrors||t.break()}))})),e.ok(a)}};t.default=o},4426:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,i.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=r},5765:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const i=n(9029),r=n(4227),o=n(2023),s=n(4227);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:i._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return i._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,r){const o=i._`${t}${(0,i.getProperty)(n)} === undefined`;return r?(0,i.or)(o,(0,i.not)(l(e,t,n))):o}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:r,it:o}=e;n.if(c(n,r,t,o.opts.ownProperties),(()=>{e.setParams({missingProperty:i._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},r,o){return(0,i.or)(...r.map((r=>(0,i.and)(c(e,t,r,n.ownProperties),i._`${o} = ${r}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,r){const o=i._`${t}${(0,i.getProperty)(n)} !== undefined`;return r?i._`${o} && ${l(e,t,n)}`:o},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,r.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:r,schemaPath:s,errorPath:a},it:l},c,u,h){const d=h?i._`${e}, ${t}, ${r}${s}`:t,p=[[o.default.instancePath,(0,i.strConcat)(o.default.instancePath,a)],[o.default.parentData,l.parentData],[o.default.parentDataProperty,l.parentDataProperty],[o.default.rootData,o.default.rootData]];l.opts.dynamicRef&&p.push([o.default.dynamicAnchors,o.default.dynamicAnchors]);const m=i._`${d}, ${n.object(...p)}`;return u!==i.nil?i._`${c}.call(${u}, ${m})`:i._`${c}(${m})`};const h=i._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const r=t.unicodeRegExp?"u":"",{regExp:o}=t.code,a=o(n,r);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:i._`${"new RegExp"===o.code?h:(0,s.useFunc)(e,o)}(${n}, ${r})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:o,it:s}=e,a=t.name("valid");if(s.allErrors){const e=t.let("valid",!0);return l((()=>t.assign(e,!1))),e}return t.var(a,!0),l((()=>t.break())),a;function l(s){const l=t.const("len",i._`${n}.length`);t.forRange("i",0,l,(n=>{e.subschema({keyword:o,dataProp:n,dataPropType:r.Type.Num},a),t.if((0,i.not)(a),s)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:o,it:s}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,r.alwaysValidSchema)(s,e)))&&!s.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block((()=>n.forEach(((n,r)=>{const s=e.subschema({keyword:o,schemaProp:r,compositeRule:!0},l);t.assign(a,i._`${a} || ${l}`),e.mergeValidEvaluated(s,l)||t.if((0,i.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},3463:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},2128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3463),r=n(3693),o=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",i.default,r.default];t.default=o},3693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const i=n(4551),r=n(5765),o=n(9029),s=n(2023),a=n(3835),l=n(4227),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:r}=e,{baseId:s,schemaEnv:l,validateName:c,opts:d,self:p}=r,{root:m}=l;if(("#"===n||"#/"===n)&&s===m.baseId)return function(){if(l===m)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:m});return h(e,o._`${n}.validate`,m,m.$async)}();const f=a.resolveRef.call(p,m,s,n);if(void 0===f)throw new i.default(r.opts.uriResolver,s,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(f):function(i){const r=t.scopeValue("schema",!0===d.code.source?{ref:i,code:(0,o.stringify)(i)}:{ref:i}),s=t.name("valid"),a=e.subschema({schema:i,dataTypes:[],schemaPath:o.nil,topSchemaRef:r,errSchemaPath:n},s);e.mergeEvaluated(a),e.ok(s)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):o._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,i){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,p=d.passContext?s.default.this:o.nil;function m(e){const t=o._`${e}.errors`;a.assign(s.default.vErrors,o._`${s.default.vErrors} === null ? ${t} : ${s.default.vErrors}.concat(${t})`),a.assign(s.default.errors,o._`${s.default.vErrors}.length`)}function f(e){var t;if(!c.opts.unevaluated)return;const i=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(i&&!i.dynamicProps)void 0!==i.props&&(c.props=l.mergeEvaluated.props(a,i.props,c.props));else{const t=a.var("props",o._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,o.Name)}if(!0!==c.items)if(i&&!i.dynamicItems)void 0!==i.items&&(c.items=l.mergeEvaluated.items(a,i.items,c.items));else{const t=a.var("items",o._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,o.Name)}}i?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(o._`await ${(0,r.callValidateCode)(e,t,p)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(o._`!(${e} instanceof ${c.ValidationError})`,(()=>a.throw(e))),m(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,r.callValidateCode)(e,t,p),(()=>f(t)),(()=>m(t)))}t.getValidate=u,t.callRef=h,t.default=c},6653:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(7652),o=n(3835),s=n(4551),a=n(4227),l={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===r.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>i._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:l,parentSchema:c,it:u}=e,{oneOf:h}=c;if(!u.opts.discriminator)throw new Error("discriminator: requires discriminator option");const d=l.propertyName;if("string"!=typeof d)throw new Error("discriminator: requires propertyName");if(l.mapping)throw new Error("discriminator: mapping is not supported");if(!h)throw new Error("discriminator: requires oneOf keyword");const p=t.let("valid",!1),m=t.const("tag",i._`${n}${(0,i.getProperty)(d)}`);function f(n){const r=t.name("valid"),o=e.subschema({keyword:"oneOf",schemaProp:n},r);return e.mergeEvaluated(o,i.Name),r}t.if(i._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=r(c);let i=!0;for(let t=0;t<h.length;t++){let c=h[t];if((null==c?void 0:c.$ref)&&!(0,a.schemaHasRulesButRef)(c,u.self.RULES)){const e=c.$ref;if(c=o.resolveRef.call(u.self,u.schemaEnv.root,u.baseId,e),c instanceof o.SchemaEnv&&(c=c.schema),void 0===c)throw new s.default(u.opts.uriResolver,u.baseId,e)}const p=null===(e=null==c?void 0:c.properties)||void 0===e?void 0:e[d];if("object"!=typeof p)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${d}"`);i=i&&(n||r(c)),l(p,t)}if(!i)throw new Error(`discriminator: "${d}" must be required`);return t;function r({required:e}){return Array.isArray(e)&&e.includes(d)}function l(e,t){if(e.const)p(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${d}" must have "const" or "enum"`);for(const n of e.enum)p(n,t)}}function p(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${d}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(i._`${m} === ${e}`),t.assign(p,f(n[e]));t.else(),e.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:d}),t.endIf()}()),(()=>e.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:d}))),e.ok(p)}};t.default=l},7652:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,function(e){e.Tag="tag",e.Mapping="mapping"}(n||(t.DiscrError=n={}))},6105:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(5520),a=n(5413),l=n(3265),c=n(7532),u=n(9857),h=[s.default,i.default,r.default,(0,o.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},6144:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2128),r=n(7060),o=n(6378),s=n(7532),a=n(9857),l=[i.default,r.default,(0,o.default)(),s.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},2476:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const i=n(9029),r=n(2023),o=n(3835),s=n(3693),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=i._`${r.default.dynamicAnchors}${(0,i.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:i}=e.it,{root:r,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=i.opts,h=new o.SchemaEnv({schema:n,schemaId:u,root:r,baseId:a,localRefs:l,meta:c});return o.compileSchema.call(i,h),(0,s.getValidate)(e,h)}(e);n.if(i._`!${l}`,(()=>n.assign(l,c)))}t.dynamicAnchor=l,t.default=a},3252:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const i=n(9029),r=n(2023),o=n(3693),s={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:s,it:a}=e;if("#"!==t[0])throw new Error(`"${s}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",i._`${r.default.dynamicAnchors}${(0,i.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,i){return i?()=>n.block((()=>{(0,o.callRef)(e,t),n.let(i,!0)})):()=>(0,o.callRef)(e,t)}}t.dynamicRef=a,t.default=s},5520:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),r=n(3252),o=n(2721),s=n(3799),a=[i.default,r.default,o.default,s.default];t.default=a},2721:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(2476),r=n(4227),o={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,i.dynamicAnchor)(e,""):(0,r.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=o},3799:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3252),r={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,i.dynamicRef)(e,e.schema)};t.default=r},4737:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>i.str`must match format "${e}"`,params:({schemaCode:e})=>i._`{format: ${e}}`},code(e,t){const{gen:n,data:r,$data:o,schema:s,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(o?function(){const o=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),s=n.const("fDef",i._`${o}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(i._`typeof ${s} == "object" && !(${s} instanceof RegExp)`,(()=>n.assign(l,i._`${s}.type || "string"`).assign(u,i._`${s}.validate`)),(()=>n.assign(l,i._`"string"`).assign(u,s))),e.fail$data((0,i.or)(!1===c.strictSchema?i.nil:i._`${a} && !${u}`,function(){const e=h.$async?i._`(${s}.async ? await ${u}(${r}) : ${u}(${r}))`:i._`${u}(${r})`,n=i._`(typeof ${u} == "function" ? ${e} : ${u}.test(${r}))`;return i._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const o=d.formats[s];if(!o)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${s}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===o)return;const[a,l,p]=function(e){const t=e instanceof RegExp?(0,i.regexpCode)(e):c.code.formats?i._`${c.code.formats}${(0,i.getProperty)(s)}`:void 0,r=n.scopeValue("formats",{key:s,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,r]:[e.type||"string",e.validate,i._`${r}.validate`]}(o);a===t&&e.pass(function(){if("object"==typeof o&&!(o instanceof RegExp)&&o.async){if(!h.$async)throw new Error("async format in sync schema");return i._`await ${p}(${r})`}return"function"==typeof l?i._`${p}(${r})`:i._`${p}.test(${r})`}())}())}};t.default=r},7532:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=[n(4737).default];t.default=i},9857:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},5413:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(1846),r=n(4845),o=n(2626),s=[i.default,r.default,o.default];t.default=s},3265:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(392),r=n(3445),o=[i.default,r.default];t.default=o},3445:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>i.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>i._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:o,it:s}=e,a=s.items||0;if(!0===a)return;const l=t.const("len",i._`${o}.length`);if(!1===n)e.setParams({len:a}),e.fail(i._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(s,n)){const n=t.var("valid",i._`${l} <= ${a}`);t.if((0,i.not)(n),(()=>function(n,o){t.forRange("i",o,l,(o=>{e.subschema({keyword:"unevaluatedItems",dataProp:o,dataPropType:r.Type.Num},n),s.allErrors||t.if((0,i.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}s.items=!0}};t.default=o},392:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(2023),s={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>i._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:s,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(o){if(!1===n)return e.setParams({unevaluatedProperty:o}),e.error(),void(c||t.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:o,dataPropType:r.Type.Str},n),c||t.if((0,i.not)(n),(()=>t.break()))}}u instanceof i.Name?t.if(i._`${u} !== true`,(()=>t.forIn("key",s,(e=>t.if(function(e,t){return i._`!${e} || !${e}[${t}]`}(u,e),(()=>h(e))))))):!0!==u&&t.forIn("key",s,(e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const r in e)!0===e[r]&&n.push(i._`${t} !== ${r}`);return(0,i.and)(...n)}(u,e),(()=>h(e))))),l.props=!0,e.ok(i._`${a} === ${o.default.errors}`)}};t.default=s},7935:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>i._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:s,schemaCode:a,schema:l}=e;s||l&&"object"==typeof l?e.fail$data(i._`!${(0,r.useFunc)(t,o.default)}(${n}, ${a})`):e.fail(i._`${l} !== ${n}`)}};t.default=s},1846:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(3025),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:i.error,code:e=>(0,i.validatePropertyDeps)(e)};t.default=r},8643:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(6250),s={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>i._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:s,schema:a,schemaCode:l,it:c}=e;if(!s&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,r.useFunc)(t,o.default);let p;if(u||s)p=t.let("valid"),e.block$data(p,(function(){t.assign(p,!1),t.forOf("v",l,(e=>t.if(i._`${d()}(${n}, ${e})`,(()=>t.assign(p,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);p=(0,i.or)(...a.map(((t,r)=>function(e,t){const r=a[t];return"object"==typeof r&&null!==r?i._`${d()}(${n}, ${e}[${t}])`:i._`${n} === ${r}`}(e,r))))}e.pass(p)}};t.default=s},7060:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5882),r=n(3439),o=n(7307),s=n(422),a=n(4486),l=n(4003),c=n(1163),u=n(617),h=n(7935),d=n(8643),p=[i.default,r.default,o.default,s.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=p},2626:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(4227),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,i.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=r},1163:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,o="maxItems"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`${n}.length ${o} ${r}`)}};t.default=r},7307:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=n(4227),o=n(3853),s={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:s,it:a}=e,l="maxLength"===t?i.operators.GT:i.operators.LT,c=!1===a.opts.unicode?i._`${n}.length`:i._`${(0,r.useFunc)(e.gen,o.default)}(${n})`;e.fail$data(i._`${c} ${l} ${s}`)}};t.default=s},5882:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r=i.operators,o={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},s={message:({keyword:e,schemaCode:t})=>i.str`must be ${o[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>i._`{comparison: ${o[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(o),type:"number",schemaType:"number",$data:!0,error:s,code(e){const{keyword:t,data:n,schemaCode:r}=e;e.fail$data(i._`${n} ${o[t].fail} ${r} || isNaN(${n})`)}};t.default=a},4486:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return i.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>i._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,o="maxProperties"===t?i.operators.GT:i.operators.LT;e.fail$data(i._`Object.keys(${n}).length ${o} ${r}`)}};t.default=r},3439:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(9029),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>i.str`must be multiple of ${e}`,params:({schemaCode:e})=>i._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:r,it:o}=e,s=o.opts.multipleOfPrecision,a=t.let("res"),l=s?i._`Math.abs(Math.round(${a}) - ${a}) > 1e-${s}`:i._`${a} !== parseInt(${a})`;e.fail$data(i._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};t.default=r},422:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match pattern "${e}"`,params:({schemaCode:e})=>r._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:o,schemaCode:s,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${s}, ${l}))`:(0,i.usePattern)(e,o);e.fail$data(r._`!${c}.test(${t})`)}};t.default=o},4003:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(5765),r=n(9029),o=n(4227),s={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>r.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>r._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:s,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(r.nil,d);else for(const t of n)(0,i.checkReportMissingProp)(e,t)}():function(){const o=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,o){e.setParams({missingProperty:n}),t.forOf(n,s,(()=>{t.assign(o,(0,i.propertyInData)(t,a,n,u.ownProperties)),t.if((0,r.not)(o),(()=>{e.error(),t.break()}))}),r.nil)}(o,n))),e.ok(n)}else t.if((0,i.checkMissingProp)(e,n,o)),(0,i.reportMissingProp)(e,o),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:i}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!i.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,o.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",s,(n=>{e.setParams({missingProperty:n}),t.if((0,i.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=s},617:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const i=n(208),r=n(9029),o=n(4227),s=n(6250),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>r.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>r._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),p=c.items?(0,i.getSchemaTypes)(c.items):[];function m(o,s){const a=t.name("item"),l=(0,i.checkDataTypes)(p,a,h.opts.strictNumbers,i.DataType.Wrong),c=t.const("indices",r._`{}`);t.for(r._`;${o}--;`,(()=>{t.let(a,r._`${n}[${o}]`),t.if(l,r._`continue`),p.length>1&&t.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),t.if(r._`typeof ${c}[${a}] == "number"`,(()=>{t.assign(s,r._`${c}[${a}]`),e.error(),t.assign(d,!1).break()})).code(r._`${c}[${a}] = ${o}`)}))}function f(i,a){const l=(0,o.useFunc)(t,s.default),c=t.name("outer");t.label(c).for(r._`;${i}--;`,(()=>t.for(r._`${a} = ${i}; ${a}--;`,(()=>t.if(r._`${l}(${n}[${i}], ${n}[${a}])`,(()=>{e.error(),t.assign(d,!1).break(c)}))))))}e.block$data(d,(function(){const i=t.let("i",r._`${n}.length`),o=t.let("j");e.setParams({i,j:o}),t.assign(d,!0),t.if(r._`${i} > 1`,(()=>(p.length>0&&!p.some((e=>"object"===e||"array"===e))?m:f)(i,o)))}),r._`${u} === false`),e.ok(d)}};t.default=a},5488:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=s},5999:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=s},857:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}","",{version:3,sources:["webpack://./css/monomer-manager.css"],names:[],mappings:"AAAA;IACI,2BAA2B;AAC/B;;AAEA;IACI,sBAAsB;IACtB,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;AAC3B;;AAEA;IACI,0BAA0B;AAC9B;AACA;IACI,0BAA0B;AAC9B;;AAEA;IACI,2BAA2B;AAC/B;;AAEA;IACI,WAAW;IACX,gBAAgB;IAChB,uBAAuB;IACvB,mBAAmB;AACvB;;AAEA;IACI,mBAAmB;IACnB,gBAAgB;IAChB,uBAAuB;AAC3B;;AAEA;IACI,iBAAiB;IACjB,iBAAiB;IACjB,iBAAiB;AACrB;;AAEA;IACI,8BAA8B;AAClC;;AAEA;IACI,+BAA+B;IAC/B,kBAAkB;IAClB,YAAY;IACZ,WAAW;IACX,gBAAgB;IAChB,mBAAmB;IACnB,eAAe;IACf,YAAY;IACZ,aAAa;IACb,gBAAgB;IAChB,iBAAiB;AACrB;;AAEA;IACI,sBAAsB;IACtB,gBAAgB;IAChB,gBAAgB;AACpB",sourcesContent:[".monomer-manager-root .grok-sketcher {\n min-width: unset !important;\n}\n\n.monomer-manager-root {\n width: 100% !important;\n height: 100% !important;\n}\n\n.monomer-manager-sketcher .ketcher-host {\n height: 100% !important;\n} \n\n.monomer-manager-root > div:first-child {\n flex-basis: 40% !important;\n}\n.monomer-manager-root > div:nth-child(2) {\n flex-basis: 60% !important;\n}\n\n.monomer-manager-root > div:first-child > .ui-form {\n max-width: unset !important;\n}\n\n.monomer-card-info-row {\n width: 100%;\n overflow: hidden;\n text-overflow: ellipsis;\n margin-bottom: 10px;\n}\n\n.monomer-card-info-row > div:nth-child(2) {\n white-space: nowrap;\n overflow: hidden;\n text-overflow: ellipsis;\n}\n\n.monomer-card-info-row > div:nth-child(1) {\n font-weight: bold;\n margin-right: 5px;\n text-wrap: nowrap;\n}\n\n.duplicate-monomer-symbol-row {\n visibility: visible !important;\n}\n\n.monomer-card-root {\n border: 2px solid var(--grey-2);\n border-radius: 5px;\n padding: 5px;\n margin: 5px;\n overflow: hidden;\n align-items: center;\n cursor: pointer;\n width: 200px;\n height: 300px;\n min-width: 200px;\n min-height: 300px;\n}\n\n.duplicate-monomers-virtual-view {\n width: 100% !important;\n overflow-x: clip;\n overflow-y: auto;\n}"],sourceRoot:""}]);const a=s},6369:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=s},7939:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=s},3017:(e,t,n)=>{"use strict";n.d(t,{A:()=>a});var i=n(1354),r=n.n(i),o=n(6314),s=n.n(o)()(r());s.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=s},6314:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",i=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),i&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),i&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,i,r,o){"string"==typeof e&&(e=[[null,e,void 0]]);var s={};if(i)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(s[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);i&&s[u[0]]||(void 0!==o&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=o),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),r&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=r):u[4]="".concat(r)),t.push(u))}},t}},1354:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var i=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(i),o="/*# ".concat(r," */");return[t].concat([o]).join("\n")}return[t].join("\n")}},2017:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var i,r,o;if(Array.isArray(t)){if((i=t.length)!=n.length)return!1;for(r=i;0!=r--;)if(!e(t[r],n[r]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((i=(o=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(r=i;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,o[r]))return!1;for(r=i;0!=r--;){var s=o[r];if(!e(t[s],n[s]))return!1}return!0}return t!=t&&n!=n}},9982:function(e,t,n){var i;!function(){var t={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,i,r,o){for(var s,a,l,c,u,h,d,p,m,f,g,y,b;o>=64;){for(s=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],p=n[7],f=0;f<16;f++)g=r+4*f,e[f]=(255&i[g])<<24|(255&i[g+1])<<16|(255&i[g+2])<<8|255&i[g+3];for(f=16;f<64;f++)y=((m=e[f-2])>>>17|m<<15)^(m>>>19|m<<13)^m>>>10,b=((m=e[f-15])>>>7|m<<25)^(m>>>18|m<<14)^m>>>3,e[f]=(y+e[f-7]|0)+(b+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(p+(t[f]+e[f]|0)|0)|0,b=((s>>>2|s<<30)^(s>>>13|s<<19)^(s>>>22|s<<10))+(s&a^s&l^a&l)|0,p=d,d=h,h=u,u=c+y|0,c=l,l=a,a=s,s=y+b|0;n[0]+=s,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=p,r+=64,o-=64}return r}var i=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var i=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[i++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(i=n(this.temp,this.state,e,i,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[i++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,i=this.bufferLength,r=t/536870912|0,o=t<<3,s=t%64<56?64:128;this.buffer[i]=128;for(var a=i+1;a<s-8;a++)this.buffer[a]=0;this.buffer[s-8]=r>>>24&255,this.buffer[s-7]=r>>>16&255,this.buffer[s-6]=r>>>8&255,this.buffer[s-5]=r>>>0&255,this.buffer[s-4]=o>>>24&255,this.buffer[s-3]=o>>>16&255,this.buffer[s-2]=o>>>8&255,this.buffer[s-1]=o>>>0&255,n(this.temp,this.state,this.buffer,0,s),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=i;var r=function(){function e(e){this.inner=new i,this.outer=new i,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new i).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function o(e){var t=(new i).update(e),n=t.digest();return t.clean(),n}function s(e,t){var n=new r(e).update(t),i=n.digest();return n.clean(),i}function a(e,t,n,i){var r=i[0];if(0===r)throw new Error("hkdf: cannot expand more");t.reset(),r>1&&t.update(e),n&&t.update(n),t.update(i),t.finish(e),i[0]++}e.HMAC=r,e.hash=o,e.default=o,e.hmac=s;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,i){void 0===t&&(t=l),void 0===i&&(i=32);for(var o=new Uint8Array([1]),c=s(t,e),u=new r(c),h=new Uint8Array(u.digestLength),d=h.length,p=new Uint8Array(i),m=0;m<i;m++)d===h.length&&(a(h,u,n,o),d=0),p[m]=h[d++];return u.clean(),h.fill(0),o.fill(0),p},e.pbkdf2=function(e,t,n,i){for(var o=new r(e),s=o.digestLength,a=new Uint8Array(4),l=new Uint8Array(s),c=new Uint8Array(s),u=new Uint8Array(i),h=0;h*s<i;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,o.reset(),o.update(t),o.update(a),o.finish(c);for(var p=0;p<s;p++)l[p]=c[p];for(p=2;p<=n;p++){o.reset(),o.update(c).finish(c);for(var m=0;m<s;m++)l[m]^=c[m]}for(p=0;p<s&&h*s+p<i;p++)u[h*s+p]=l[p]}for(h=0;h<s;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return o.clean(),u}}(t);var r=t.default;for(var o in t)r[o]=t[o];"object"==typeof e.exports?e.exports=r:void 0===(i=function(){return r}.call(t,n,t,e))||(e.exports=i)}()},2787:(e,t,n)=>{"use strict";n.d(t,{I:()=>r});const i=new Uint32Array(65536),r=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,r=t.length,o=1<<n-1;let s=-1,a=0,l=n,c=n;for(;c--;)i[e.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let e=i[t.charCodeAt(c)];const n=e|a;e|=(e&s)+s^s,a|=~(e|s),s&=e,a&o&&l++,s&o&&l--,a=a<<1|1,s=s<<1|~(n|a),a&=n}for(c=n;c--;)i[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,r=e.length,o=[],s=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let e=0;e<a;e++)s[e]=-1,o[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,r)+u;for(let t=u;t<h;t++)i[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],r=s[e/32|0]>>>e&1,c=o[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),p=l&h;d>>>31^r&&(s[e/32|0]^=1<<e),p>>>31^c&&(o[e/32|0]^=1<<e),d=d<<1|r,p=p<<1|c,l=p|~(u|d),a=d&u}for(let t=u;t<h;t++)i[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,p=Math.min(32,r-d)+d;for(let t=d;t<p;t++)i[e.charCodeAt(t)]|=1<<t;let m=r;for(let e=0;e<n;e++){const n=i[t.charCodeAt(e)],a=s[e/32|0]>>>e&1,l=o[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let p=u|~(d|h),f=h&d;m+=p>>>r-1&1,m-=f>>>r-1&1,p>>>31^a&&(s[e/32|0]^=1<<e),f>>>31^l&&(o[e/32|0]^=1<<e),p=p<<1|a,f=f<<1|l,h=f|~(c|p),u=p&c}for(let t=d;t<p;t++)i[e.charCodeAt(t)]=0;return m})(e,t)}},9937:e=>{e.exports={linLogMode:!1,outboundAttractionDistribution:!1,adjustSizes:!1,edgeWeightInfluence:1,scalingRatio:1,strongGravityMode:!1,gravity:1,slowDown:1,barnesHutOptimize:!1,barnesHutTheta:.5}},1782:(e,t)=>{t.assign=function(e){e=e||{};var t,n,i,r=Array.prototype.slice.call(arguments).slice(1);for(t=0,i=r.length;t<i;t++)if(r[t])for(n in r[t])e[n]=r[t][n];return e},t.validateSettings=function(e){return"linLogMode"in e&&"boolean"!=typeof e.linLogMode?{message:"the `linLogMode` setting should be a boolean."}:"outboundAttractionDistribution"in e&&"boolean"!=typeof e.outboundAttractionDistribution?{message:"the `outboundAttractionDistribution` setting should be a boolean."}:"adjustSizes"in e&&"boolean"!=typeof e.adjustSizes?{message:"the `adjustSizes` setting should be a boolean."}:"edgeWeightInfluence"in e&&"number"!=typeof e.edgeWeightInfluence?{message:"the `edgeWeightInfluence` setting should be a number."}:!("scalingRatio"in e)||"number"==typeof e.scalingRatio&&e.scalingRatio>=0?"strongGravityMode"in e&&"boolean"!=typeof e.strongGravityMode?{message:"the `strongGravityMode` setting should be a boolean."}:!("gravity"in e)||"number"==typeof e.gravity&&e.gravity>=0?"slowDown"in e&&!("number"==typeof e.slowDown||e.slowDown>=0)?{message:"the `slowDown` setting should be a number >= 0."}:"barnesHutOptimize"in e&&"boolean"!=typeof e.barnesHutOptimize?{message:"the `barnesHutOptimize` setting should be a boolean."}:!("barnesHutTheta"in e)||"number"==typeof e.barnesHutTheta&&e.barnesHutTheta>=0?null:{message:"the `barnesHutTheta` setting should be a number >= 0."}:{message:"the `gravity` setting should be a number >= 0."}:{message:"the `scalingRatio` setting should be a number >= 0."}},t.graphToByteArrays=function(e,t){var n,i=e.order,r=e.size,o={},s=new Float32Array(10*i),a=new Float32Array(3*r);return n=0,e.forEachNode((function(e,t){o[e]=n,s[n]=t.x,s[n+1]=t.y,s[n+2]=0,s[n+3]=0,s[n+4]=0,s[n+5]=0,s[n+6]=1,s[n+7]=1,s[n+8]=t.size||1,s[n+9]=t.fixed?1:0,n+=10})),n=0,e.forEachEdge((function(e,i,r,l,c,u,h){var d=o[r],p=o[l],m=t(e,i,r,l,c,u,h);s[d+6]+=m,s[p+6]+=m,a[n]=d,a[n+1]=p,a[n+2]=m,n+=3})),{nodes:s,edges:a}},t.assignLayoutChanges=function(e,t,n){var i=0;e.updateEachNodeAttributes((function(e,r){return r.x=t[i],r.y=t[i+1],i+=10,n?n(e,r):r}))},t.readGraphPositions=function(e,t){var n=0;e.forEachNode((function(e,i){t[n]=i.x,t[n+1]=i.y,n+=10}))},t.collectLayoutChanges=function(e,t,n){for(var i=e.nodes(),r={},o=0,s=0,a=t.length;o<a;o+=10){if(n){var l=Object.assign({},e.getNodeAttributes(i[s]));l.x=t[o],l.y=t[o+1],l=n(i[s],l),r[i[s]]={x:l.x,y:l.y}}else r[i[s]]={x:t[o],y:t[o+1]};s++}return r},t.createWorker=function(e){var t=window.URL||window.webkitURL,n=e.toString(),i=t.createObjectURL(new Blob(["("+n+").call(this);"],{type:"text/javascript"})),r=new Worker(i);return t.revokeObjectURL(i),r}},8903:(e,t,n)=>{var i=n(1736),r=n(8153).Fd,o=n(2561),s=n(1782),a=n(9937);function l(e,t,n){if(!i(t))throw new Error("graphology-layout-forceatlas2: the given graph is not a valid graphology instance.");"number"==typeof n&&(n={iterations:n});var l=n.iterations;if("number"!=typeof l)throw new Error("graphology-layout-forceatlas2: invalid number of iterations.");if(l<=0)throw new Error("graphology-layout-forceatlas2: you should provide a positive number of iterations.");var c=r("getEdgeWeight"in n?n.getEdgeWeight:"weight").fromEntry,u="function"==typeof n.outputReducer?n.outputReducer:null,h=s.assign({},a,n.settings),d=s.validateSettings(h);if(d)throw new Error("graphology-layout-forceatlas2: "+d.message);var p,m=s.graphToByteArrays(t,c);for(p=0;p<l;p++)o(h,m.nodes,m.edges);if(!e)return s.collectLayoutChanges(t,m.nodes);s.assignLayoutChanges(t,m.nodes,u)}var c=l.bind(null,!1);c.assign=l.bind(null,!0),c.inferSettings=function(e){var t="number"==typeof e?e:e.order;return{barnesHutOptimize:t>2e3,strongGravityMode:!0,gravity:.05,scalingRatio:10,slowDown:1+Math.log(t)}},e.exports=c},2561:e=>{var t=10;e.exports=function(e,n,i){var r,o,s,a,l,c,u,h,d,p,m,f,g,y,b,v,w,C,A,S,x,E,_,M=n.length,I=i.length,T=e.adjustSizes,L=e.barnesHutTheta*e.barnesHutTheta,N=[];for(s=0;s<M;s+=t)n[s+4]=n[s+2],n[s+5]=n[s+3],n[s+2]=0,n[s+3]=0;if(e.outboundAttractionDistribution){for(m=0,s=0;s<M;s+=t)m+=n[s+6];m/=M/t}if(e.barnesHutOptimize){var $,P,R,O=1/0,k=-1/0,G=1/0,F=-1/0;for(s=0;s<M;s+=t)O=Math.min(O,n[s+0]),k=Math.max(k,n[s+0]),G=Math.min(G,n[s+1]),F=Math.max(F,n[s+1]);var D=k-O,B=F-G;for(D>B?F=(G-=(D-B)/2)+D:k=(O-=(B-D)/2)+B,N[0]=-1,N[1]=(O+k)/2,N[2]=(G+F)/2,N[3]=Math.max(k-O,F-G),N[4]=-1,N[5]=-1,N[6]=0,N[7]=0,N[8]=0,r=1,s=0;s<M;s+=t)for(o=0,R=3;;){if(!(N[o+5]>=0)){if(N[o+0]<0){N[o+0]=s;break}if(N[o+5]=9*r,h=N[o+3]/2,N[(d=N[o+5])+0]=-1,N[d+1]=N[o+1]-h,N[d+2]=N[o+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]-h,N[d+2]=N[o+2]+h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+h,N[d+2]=N[o+2]-h,N[d+3]=h,N[d+4]=d+9,N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,N[(d+=9)+0]=-1,N[d+1]=N[o+1]+h,N[d+2]=N[o+2]+h,N[d+3]=h,N[d+4]=N[o+4],N[d+5]=-1,N[d+6]=0,N[d+7]=0,N[d+8]=0,r+=4,$=n[N[o+0]+0]<N[o+1]?n[N[o+0]+1]<N[o+2]?N[o+5]:N[o+5]+9:n[N[o+0]+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+6]=n[N[o+0]+6],N[o+7]=n[N[o+0]+0],N[o+8]=n[N[o+0]+1],N[$+0]=N[o+0],N[o+0]=-1,$===(P=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27)){if(R--){o=$;continue}R=3;break}N[P+0]=s;break}$=n[s+0]<N[o+1]?n[s+1]<N[o+2]?N[o+5]:N[o+5]+9:n[s+1]<N[o+2]?N[o+5]+18:N[o+5]+27,N[o+7]=(N[o+7]*N[o+6]+n[s+0]*n[s+6])/(N[o+6]+n[s+6]),N[o+8]=(N[o+8]*N[o+6]+n[s+1]*n[s+6])/(N[o+6]+n[s+6]),N[o+6]+=n[s+6],o=$}}if(e.barnesHutOptimize){for(f=e.scalingRatio,s=0;s<M;s+=t)for(o=0;;)if(N[o+5]>=0){if(v=Math.pow(n[s+0]-N[o+7],2)+Math.pow(n[s+1]-N[o+8],2),4*(p=N[o+3])*p/v<L){if(g=n[s+0]-N[o+7],y=n[s+1]-N[o+8],!0===T?v>0?(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*N[o+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*N[o+6]/v,n[s+2]+=g*w,n[s+3]+=y*w),(o=N[o+4])<0)break;continue}o=N[o+5]}else if((c=N[o+0])>=0&&c!==s&&(v=(g=n[s+0]-n[c+0])*g+(y=n[s+1]-n[c+1])*y,!0===T?v>0?(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w):v<0&&(w=-f*n[s+6]*n[c+6]/Math.sqrt(v),n[s+2]+=g*w,n[s+3]+=y*w):v>0&&(w=f*n[s+6]*n[c+6]/v,n[s+2]+=g*w,n[s+3]+=y*w)),(o=N[o+4])<0)break}else for(f=e.scalingRatio,a=0;a<M;a+=t)for(l=0;l<a;l+=t)g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8])>0?(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):v<0&&(w=100*f*n[a+6]*n[l+6],n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w):(v=Math.sqrt(g*g+y*y))>0&&(w=f*n[a+6]*n[l+6]/v/v,n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);for(d=e.gravity/e.scalingRatio,f=e.scalingRatio,s=0;s<M;s+=t)w=0,g=n[s+0],y=n[s+1],v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.strongGravityMode?v>0&&(w=f*n[s+6]*d):v>0&&(w=f*n[s+6]*d/v),n[s+2]-=g*w,n[s+3]-=y*w;for(f=1*(e.outboundAttractionDistribution?m:1),u=0;u<I;u+=3)a=i[u+0],l=i[u+1],h=i[u+2],b=Math.pow(h,e.edgeWeightInfluence),g=n[a+0]-n[l+0],y=n[a+1]-n[l+1],!0===T?(v=Math.sqrt(g*g+y*y)-n[a+8]-n[l+8],e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?v>0&&(w=-f*b/n[a+6]):v>0&&(w=-f*b)):(v=Math.sqrt(Math.pow(g,2)+Math.pow(y,2)),e.linLogMode?e.outboundAttractionDistribution?v>0&&(w=-f*b*Math.log(1+v)/v/n[a+6]):v>0&&(w=-f*b*Math.log(1+v)/v):e.outboundAttractionDistribution?(v=1,w=-f*b/n[a+6]):(v=1,w=-f*b)),v>0&&(n[a+2]+=g*w,n[a+3]+=y*w,n[l+2]-=g*w,n[l+3]-=y*w);if(!0===T)for(s=0;s<M;s+=t)1!==n[s+9]&&((C=Math.sqrt(Math.pow(n[s+2],2)+Math.pow(n[s+3],2)))>10&&(n[s+2]=10*n[s+2]/C,n[s+3]=10*n[s+3]/C),A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=.1*Math.log(1+S)/(1+Math.sqrt(A)),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,_=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=_);else for(s=0;s<M;s+=t)1!==n[s+9]&&(A=n[s+6]*Math.sqrt((n[s+4]-n[s+2])*(n[s+4]-n[s+2])+(n[s+5]-n[s+3])*(n[s+5]-n[s+3])),S=Math.sqrt((n[s+4]+n[s+2])*(n[s+4]+n[s+2])+(n[s+5]+n[s+3])*(n[s+5]+n[s+3]))/2,x=n[s+7]*Math.log(1+S)/(1+Math.sqrt(A)),n[s+7]=Math.min(1,Math.sqrt(x*(Math.pow(n[s+2],2)+Math.pow(n[s+3],2))/(1+Math.sqrt(A)))),E=n[s+0]+n[s+2]*(x/e.slowDown),n[s+0]=E,_=n[s+1]+n[s+3]*(x/e.slowDown),n[s+1]=_);return{}}},8153:(e,t)=>{function n(e){return"number"!=typeof e||isNaN(e)?1:e}t.Fd=function(e){return function(e,t){var n={},i=function(e){return void 0===e?t:e};"function"==typeof t&&(i=t);var r=function(t){return i(t[e])},o=function(){return i(void 0)};return"string"==typeof e?(n.fromAttributes=r,n.fromGraph=function(e,t){return r(e.getEdgeAttributes(t))},n.fromEntry=function(e,t){return r(t)},n.fromPartialEntry=n.fromEntry,n.fromMinimalEntry=n.fromEntry):"function"==typeof e?(n.fromAttributes=function(){throw new Error("graphology-utils/getters/createEdgeValueGetter: irrelevant usage.")},n.fromGraph=function(t,n){var r=t.extremities(n);return i(e(n,t.getEdgeAttributes(n),r[0],r[1],t.getNodeAttributes(r[0]),t.getNodeAttributes(r[1]),t.isUndirected(n)))},n.fromEntry=function(t,n,r,o,s,a,l){return i(e(t,n,r,o,s,a,l))},n.fromPartialEntry=function(t,n,r,o){return i(e(t,n,r,o))},n.fromMinimalEntry=function(t,n){return i(e(t,n))}):(n.fromAttributes=o,n.fromGraph=o,n.fromEntry=o,n.fromMinimalEntry=o),n}(e,n)}},1736:e=>{e.exports=function(e){return null!==e&&"object"==typeof e&&"function"==typeof e.addUndirectedEdgeWithKey&&"function"==typeof e.dropNode&&"boolean"==typeof e.multi}},934:function(e){e.exports=function(){"use strict";function e(t){return(e="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(e){return typeof e}:function(e){return e&&"function"==typeof Symbol&&e.constructor===Symbol&&e!==Symbol.prototype?"symbol":typeof e})(t)}function t(e,t){e.prototype=Object.create(t.prototype),e.prototype.constructor=e,i(e,t)}function n(e){return n=Object.setPrototypeOf?Object.getPrototypeOf.bind():function(e){return e.__proto__||Object.getPrototypeOf(e)},n(e)}function i(e,t){return i=Object.setPrototypeOf?Object.setPrototypeOf.bind():function(e,t){return e.__proto__=t,e},i(e,t)}function r(e,t,n){return r=function(){if("undefined"==typeof Reflect||!Reflect.construct)return!1;if(Reflect.construct.sham)return!1;if("function"==typeof Proxy)return!0;try{return Boolean.prototype.valueOf.call(Reflect.construct(Boolean,[],(function(){}))),!0}catch(e){return!1}}()?Reflect.construct.bind():function(e,t,n){var r=[null];r.push.apply(r,t);var o=new(Function.bind.apply(e,r));return n&&i(o,n.prototype),o},r.apply(null,arguments)}function o(e){var t="function"==typeof Map?new Map:void 0;return o=function(e){if(null===e||(o=e,-1===Function.toString.call(o).indexOf("[native code]")))return e;var o;if("function"!=typeof e)throw new TypeError("Super expression must either be null or a function");if(void 0!==t){if(t.has(e))return t.get(e);t.set(e,s)}function s(){return r(e,arguments,n(this).constructor)}return s.prototype=Object.create(e.prototype,{constructor:{value:s,enumerable:!1,writable:!0,configurable:!0}}),i(s,e)},o(e)}function s(e){if(void 0===e)throw new ReferenceError("this hasn't been initialised - super() hasn't been called");return e}var a=function(){for(var e=arguments[0],t=1,n=arguments.length;t<n;t++)if(arguments[t])for(var i in arguments[t])e[i]=arguments[t][i];return e};function l(e,t,n,i){var r=e._nodes.get(t),o=null;return r?o="mixed"===i?r.out&&r.out[n]||r.undirected&&r.undirected[n]:"directed"===i?r.out&&r.out[n]:r.undirected&&r.undirected[n]:o}function c(t){return"object"===e(t)&&null!==t}function u(e){var t;for(t in e)return!1;return!0}function h(e,t,n){Object.defineProperty(e,t,{enumerable:!1,configurable:!1,writable:!0,value:n})}function d(e,t,n){var i={enumerable:!0,configurable:!0};"function"==typeof n?i.get=n:(i.value=n,i.writable=!1),Object.defineProperty(e,t,i)}function p(e){return!(!c(e)||e.attributes&&!Array.isArray(e.attributes))}"function"==typeof Object.assign&&(a=Object.assign);var m,f={exports:{}},g="object"==typeof Reflect?Reflect:null,y=g&&"function"==typeof g.apply?g.apply:function(e,t,n){return Function.prototype.apply.call(e,t,n)};m=g&&"function"==typeof g.ownKeys?g.ownKeys:Object.getOwnPropertySymbols?function(e){return Object.getOwnPropertyNames(e).concat(Object.getOwnPropertySymbols(e))}:function(e){return Object.getOwnPropertyNames(e)};var b=Number.isNaN||function(e){return e!=e};function v(){v.init.call(this)}f.exports=v,f.exports.once=function(e,t){return new Promise((function(n,i){function r(n){e.removeListener(t,o),i(n)}function o(){"function"==typeof e.removeListener&&e.removeListener("error",r),n([].slice.call(arguments))}T(e,t,o,{once:!0}),"error"!==t&&function(e,t){"function"==typeof e.on&&T(e,"error",t,{once:!0})}(e,r)}))},v.EventEmitter=v,v.prototype._events=void 0,v.prototype._eventsCount=0,v.prototype._maxListeners=void 0;var w=10;function C(e){if("function"!=typeof e)throw new TypeError('The "listener" argument must be of type Function. Received type '+typeof e)}function A(e){return void 0===e._maxListeners?v.defaultMaxListeners:e._maxListeners}function S(e,t,n,i){var r,o,s,a;if(C(n),void 0===(o=e._events)?(o=e._events=Object.create(null),e._eventsCount=0):(void 0!==o.newListener&&(e.emit("newListener",t,n.listener?n.listener:n),o=e._events),s=o[t]),void 0===s)s=o[t]=n,++e._eventsCount;else if("function"==typeof s?s=o[t]=i?[n,s]:[s,n]:i?s.unshift(n):s.push(n),(r=A(e))>0&&s.length>r&&!s.warned){s.warned=!0;var l=new Error("Possible EventEmitter memory leak detected. "+s.length+" "+String(t)+" listeners added. Use emitter.setMaxListeners() to increase limit");l.name="MaxListenersExceededWarning",l.emitter=e,l.type=t,l.count=s.length,a=l,console&&console.warn&&console.warn(a)}return e}function x(){if(!this.fired)return this.target.removeListener(this.type,this.wrapFn),this.fired=!0,0===arguments.length?this.listener.call(this.target):this.listener.apply(this.target,arguments)}function E(e,t,n){var i={fired:!1,wrapFn:void 0,target:e,type:t,listener:n},r=x.bind(i);return r.listener=n,i.wrapFn=r,r}function _(e,t,n){var i=e._events;if(void 0===i)return[];var r=i[t];return void 0===r?[]:"function"==typeof r?n?[r.listener||r]:[r]:n?function(e){for(var t=new Array(e.length),n=0;n<t.length;++n)t[n]=e[n].listener||e[n];return t}(r):I(r,r.length)}function M(e){var t=this._events;if(void 0!==t){var n=t[e];if("function"==typeof n)return 1;if(void 0!==n)return n.length}return 0}function I(e,t){for(var n=new Array(t),i=0;i<t;++i)n[i]=e[i];return n}function T(e,t,n,i){if("function"==typeof e.on)i.once?e.once(t,n):e.on(t,n);else{if("function"!=typeof e.addEventListener)throw new TypeError('The "emitter" argument must be of type EventEmitter. Received type '+typeof e);e.addEventListener(t,(function r(o){i.once&&e.removeEventListener(t,r),n(o)}))}}function L(e){if("function"!=typeof e)throw new Error("obliterator/iterator: expecting a function!");this.next=e}Object.defineProperty(v,"defaultMaxListeners",{enumerable:!0,get:function(){return w},set:function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "defaultMaxListeners" is out of range. It must be a non-negative number. Received '+e+".");w=e}}),v.init=function(){void 0!==this._events&&this._events!==Object.getPrototypeOf(this)._events||(this._events=Object.create(null),this._eventsCount=0),this._maxListeners=this._maxListeners||void 0},v.prototype.setMaxListeners=function(e){if("number"!=typeof e||e<0||b(e))throw new RangeError('The value of "n" is out of range. It must be a non-negative number. Received '+e+".");return this._maxListeners=e,this},v.prototype.getMaxListeners=function(){return A(this)},v.prototype.emit=function(e){for(var t=[],n=1;n<arguments.length;n++)t.push(arguments[n]);var i="error"===e,r=this._events;if(void 0!==r)i=i&&void 0===r.error;else if(!i)return!1;if(i){var o;if(t.length>0&&(o=t[0]),o instanceof Error)throw o;var s=new Error("Unhandled error."+(o?" ("+o.message+")":""));throw s.context=o,s}var a=r[e];if(void 0===a)return!1;if("function"==typeof a)y(a,this,t);else{var l=a.length,c=I(a,l);for(n=0;n<l;++n)y(c[n],this,t)}return!0},v.prototype.addListener=function(e,t){return S(this,e,t,!1)},v.prototype.on=v.prototype.addListener,v.prototype.prependListener=function(e,t){return S(this,e,t,!0)},v.prototype.once=function(e,t){return C(t),this.on(e,E(this,e,t)),this},v.prototype.prependOnceListener=function(e,t){return C(t),this.prependListener(e,E(this,e,t)),this},v.prototype.removeListener=function(e,t){var n,i,r,o,s;if(C(t),void 0===(i=this._events))return this;if(void 0===(n=i[e]))return this;if(n===t||n.listener===t)0==--this._eventsCount?this._events=Object.create(null):(delete i[e],i.removeListener&&this.emit("removeListener",e,n.listener||t));else if("function"!=typeof n){for(r=-1,o=n.length-1;o>=0;o--)if(n[o]===t||n[o].listener===t){s=n[o].listener,r=o;break}if(r<0)return this;0===r?n.shift():function(e,t){for(;t+1<e.length;t++)e[t]=e[t+1];e.pop()}(n,r),1===n.length&&(i[e]=n[0]),void 0!==i.removeListener&&this.emit("removeListener",e,s||t)}return this},v.prototype.off=v.prototype.removeListener,v.prototype.removeAllListeners=function(e){var t,n,i;if(void 0===(n=this._events))return this;if(void 0===n.removeListener)return 0===arguments.length?(this._events=Object.create(null),this._eventsCount=0):void 0!==n[e]&&(0==--this._eventsCount?this._events=Object.create(null):delete n[e]),this;if(0===arguments.length){var r,o=Object.keys(n);for(i=0;i<o.length;++i)"removeListener"!==(r=o[i])&&this.removeAllListeners(r);return this.removeAllListeners("removeListener"),this._events=Object.create(null),this._eventsCount=0,this}if("function"==typeof(t=n[e]))this.removeListener(e,t);else if(void 0!==t)for(i=t.length-1;i>=0;i--)this.removeListener(e,t[i]);return this},v.prototype.listeners=function(e){return _(this,e,!0)},v.prototype.rawListeners=function(e){return _(this,e,!1)},v.listenerCount=function(e,t){return"function"==typeof e.listenerCount?e.listenerCount(t):M.call(e,t)},v.prototype.listenerCount=M,v.prototype.eventNames=function(){return this._eventsCount>0?m(this._events):[]},"undefined"!=typeof Symbol&&(L.prototype[Symbol.iterator]=function(){return this}),L.of=function(){var e=arguments,t=e.length,n=0;return new L((function(){return n>=t?{done:!0}:{done:!1,value:e[n++]}}))},L.empty=function(){return new L((function(){return{done:!0}}))},L.fromSequence=function(e){var t=0,n=e.length;return new L((function(){return t>=n?{done:!0}:{done:!1,value:e[t++]}}))},L.is=function(e){return e instanceof L||"object"==typeof e&&null!==e&&"function"==typeof e.next};var N=L,$={};$.ARRAY_BUFFER_SUPPORT="undefined"!=typeof ArrayBuffer,$.SYMBOL_SUPPORT="undefined"!=typeof Symbol;var P=N,R=$,O=R.ARRAY_BUFFER_SUPPORT,k=R.SYMBOL_SUPPORT,G=function(e){var t=function(e){return"string"==typeof e||Array.isArray(e)||O&&ArrayBuffer.isView(e)?P.fromSequence(e):"object"!=typeof e||null===e?null:k&&"function"==typeof e[Symbol.iterator]?e[Symbol.iterator]():"function"==typeof e.next?e:null}(e);if(!t)throw new Error("obliterator: target is not iterable nor a valid iterator.");return t},F=G,D=function(e,t){for(var n,i=arguments.length>1?t:1/0,r=i!==1/0?new Array(i):[],o=0,s=F(e);;){if(o===i)return r;if((n=s.next()).done)return o!==t&&(r.length=o),r;r[o++]=n.value}},B=function(e){function n(t){var n;return(n=e.call(this)||this).name="GraphError",n.message=t,n}return t(n,e),n}(o(Error)),H=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="InvalidArgumentsGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),V=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="NotFoundGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B),j=function(e){function n(t){var i;return(i=e.call(this,t)||this).name="UsageGraphError","function"==typeof Error.captureStackTrace&&Error.captureStackTrace(s(i),n.prototype.constructor),i}return t(n,e),n}(B);function U(e,t){this.key=e,this.attributes=t,this.clear()}function W(e,t){this.key=e,this.attributes=t,this.clear()}function Y(e,t){this.key=e,this.attributes=t,this.clear()}function q(e,t,n,i,r){this.key=t,this.attributes=r,this.undirected=e,this.source=n,this.target=i}function z(e,t,n,i,r,o,s){var a,l,c,u;if(i=""+i,0===n){if(!(a=e._nodes.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" node in the graph.'));c=r,u=o}else if(3===n){if(r=""+r,!(l=e._edges.get(r)))throw new V("Graph.".concat(t,': could not find the "').concat(r,'" edge in the graph.'));var h=l.source.key,d=l.target.key;if(i===h)a=l.target;else{if(i!==d)throw new V("Graph.".concat(t,': the "').concat(i,'" node is not attached to the "').concat(r,'" edge (').concat(h,", ").concat(d,")."));a=l.source}c=o,u=s}else{if(!(l=e._edges.get(i)))throw new V("Graph.".concat(t,': could not find the "').concat(i,'" edge in the graph.'));a=1===n?l.source:l.target,c=r,u=o}return[a,c,u]}U.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.undirectedDegree=0,this.undirectedLoops=0,this.directedLoops=0,this.in={},this.out={},this.undirected={}},W.prototype.clear=function(){this.inDegree=0,this.outDegree=0,this.directedLoops=0,this.in={},this.out={}},Y.prototype.clear=function(){this.undirectedDegree=0,this.undirectedLoops=0,this.undirected={}},q.prototype.attach=function(){var e="out",t="in";this.undirected&&(e=t="undirected");var n=this.source.key,i=this.target.key;this.source[e][i]=this,this.undirected&&n===i||(this.target[t][n]=this)},q.prototype.attachMulti=function(){var e="out",t="in",n=this.source.key,i=this.target.key;this.undirected&&(e=t="undirected");var r=this.source[e],o=r[i];if(void 0===o)return r[i]=this,void(this.undirected&&n===i||(this.target[t][n]=this));o.previous=this,this.next=o,r[i]=this,this.target[t][n]=this},q.prototype.detach=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),delete this.source[n][t],delete this.target[i][e]},q.prototype.detachMulti=function(){var e=this.source.key,t=this.target.key,n="out",i="in";this.undirected&&(n=i="undirected"),void 0===this.previous?void 0===this.next?(delete this.source[n][t],delete this.target[i][e]):(this.next.previous=void 0,this.source[n][t]=this.next,this.target[i][e]=this.next):(this.previous.next=this.next,void 0!==this.next&&(this.next.previous=this.previous))};var K=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],a=o[1];return s.attributes[a]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){return z(this,t,n,e,i)[0].attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],a=o[1];return s.attributes.hasOwnProperty(a)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r,o){var s=z(this,t,n,e,i,r,o),a=s[0],l=s[1],c=s[2];return a.attributes[l]=c,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r,o){var s=z(this,t,n,e,i,r,o),a=s[0],l=s[1],c=s[2];if("function"!=typeof c)throw new H("Graph.".concat(t,": updater should be a function."));var u=a.attributes,h=c(u[l]);return u[l]=h,this.emit("nodeAttributesUpdated",{key:a.key,type:"set",attributes:a.attributes,name:l}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],a=o[1];return delete s.attributes[a],this.emit("nodeAttributesUpdated",{key:s.key,type:"remove",attributes:s.attributes,name:a}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],a=o[1];if(!c(a))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return s.attributes=a,this.emit("nodeAttributesUpdated",{key:s.key,type:"replace",attributes:s.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],l=o[1];if(!c(l))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return a(s.attributes,l),this.emit("nodeAttributesUpdated",{key:s.key,type:"merge",attributes:s.attributes,data:l}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o=z(this,t,n,e,i,r),s=o[0],a=o[1];if("function"!=typeof a)throw new H("Graph.".concat(t,": provided updater is not a function."));return s.attributes=a(s.attributes),this.emit("nodeAttributesUpdated",{key:s.key,type:"update",attributes:s.attributes}),this}}}],Z=[{name:function(e){return"get".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes[i]}}},{name:function(e){return"get".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e){var i;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>1){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var r=""+e,o=""+arguments[1];if(!(i=l(this,r,o,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(r,'" - "').concat(o,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(i=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return i.attributes}}},{name:function(e){return"has".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return r.attributes.hasOwnProperty(i)}}},{name:function(e){return"set".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return o.attributes[i]=r,this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(e){return"update".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i,r){var o;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>3){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var s=""+e,a=""+i;if(i=arguments[2],r=arguments[3],!(o=l(this,s,a,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(s,'" - "').concat(a,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(o=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof r)throw new H("Graph.".concat(t,": updater should be a function."));return o.attributes[i]=r(o.attributes[i]),this.emit("edgeAttributesUpdated",{key:o.key,type:"set",attributes:o.attributes,name:i}),this}}},{name:function(e){return"remove".concat(e,"Attribute")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}return delete r.attributes[i],this.emit("edgeAttributesUpdated",{key:r.key,type:"remove",attributes:r.attributes,name:i}),this}}},{name:function(e){return"replace".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return r.attributes=i,this.emit("edgeAttributesUpdated",{key:r.key,type:"replace",attributes:r.attributes}),this}}},{name:function(e){return"merge".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if(!c(i))throw new H("Graph.".concat(t,": provided attributes are not a plain object."));return a(r.attributes,i),this.emit("edgeAttributesUpdated",{key:r.key,type:"merge",attributes:r.attributes,data:i}),this}}},{name:function(e){return"update".concat(e,"Attributes")},attacher:function(e,t,n){e.prototype[t]=function(e,i){var r;if("mixed"!==this.type&&"mixed"!==n&&n!==this.type)throw new j("Graph.".concat(t,": cannot find this type of edges in your ").concat(this.type," graph."));if(arguments.length>2){if(this.multi)throw new j("Graph.".concat(t,": cannot use a {source,target} combo when asking about an edge's attributes in a MultiGraph since we cannot infer the one you want information about."));var o=""+e,s=""+i;if(i=arguments[2],!(r=l(this,o,s,n)))throw new V("Graph.".concat(t,': could not find an edge for the given path ("').concat(o,'" - "').concat(s,'").'))}else{if("mixed"!==n)throw new j("Graph.".concat(t,": calling this method with only a key (vs. a source and target) does not make sense since an edge with this key could have the other type."));if(e=""+e,!(r=this._edges.get(e)))throw new V("Graph.".concat(t,': could not find the "').concat(e,'" edge in the graph.'))}if("function"!=typeof i)throw new H("Graph.".concat(t,": provided updater is not a function."));return r.attributes=i(r.attributes),this.emit("edgeAttributesUpdated",{key:r.key,type:"update",attributes:r.attributes}),this}}}],X=N,J=G,Q=function(){var e=arguments,t=null,n=-1;return new X((function(){for(var i=null;;){if(null===t){if(++n>=e.length)return{done:!0};t=J(e[n])}if(!0!==(i=t.next()).done)break;t=null}return i}))},ee=[{name:"edges",type:"mixed"},{name:"inEdges",type:"directed",direction:"in"},{name:"outEdges",type:"directed",direction:"out"},{name:"inboundEdges",type:"mixed",direction:"in"},{name:"outboundEdges",type:"mixed",direction:"out"},{name:"directedEdges",type:"directed"},{name:"undirectedEdges",type:"undirected"}];function te(e,t,n,i){var r=!1;for(var o in t)if(o!==i){var s=t[o];if(r=n(s.key,s.attributes,s.source.key,s.target.key,s.source.attributes,s.target.attributes,s.undirected),e&&r)return s.key}}function ne(e,t,n,i){var r,o,s,a=!1;for(var l in t)if(l!==i){r=t[l];do{if(o=r.source,s=r.target,a=n(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected),e&&a)return r.key;r=r.next}while(void 0!==r)}}function ie(e,t){var n,i=Object.keys(e),r=i.length,o=0;return new N((function(){do{if(n)n=n.next;else{if(o>=r)return{done:!0};var s=i[o++];if(s===t){n=void 0;continue}n=e[s]}}while(!n);return{done:!1,value:{edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected}}}))}function re(e,t,n,i){var r=t[n];if(r){var o=r.source,s=r.target;return i(r.key,r.attributes,o.key,s.key,o.attributes,s.attributes,r.undirected)&&e?r.key:void 0}}function oe(e,t,n,i){var r=t[n];if(r){var o=!1;do{if(o=i(r.key,r.attributes,r.source.key,r.target.key,r.source.attributes,r.target.attributes,r.undirected),e&&o)return r.key;r=r.next}while(void 0!==r)}}function se(e,t){var n=e[t];return void 0!==n.next?new N((function(){if(!n)return{done:!0};var e={edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected};return n=n.next,{done:!1,value:e}})):N.of({edge:n.key,attributes:n.attributes,source:n.source.key,target:n.target.key,sourceAttributes:n.source.attributes,targetAttributes:n.target.attributes,undirected:n.undirected})}function ae(e,t,n,i){if(0!==t.size)for(var r,o,s="mixed"!==n&&n!==t.type,a="undirected"===n,l=!1,c=t._edges.values();!0!==(r=c.next()).done;)if(o=r.value,!s||o.undirected===a){var u=o,h=u.key,d=u.attributes,p=u.source,m=u.target;if(l=i(h,d,p.key,m.key,p.attributes,m.attributes,o.undirected),e&&l)return h}}function le(e,t,n,i,r,o){var s,a=t?ne:te;if("undirected"!==n){if("out"!==i&&(s=a(e,r.in,o),e&&s))return s;if("in"!==i&&(s=a(e,r.out,o,i?void 0:r.key),e&&s))return s}if("directed"!==n&&(s=a(e,r.undirected,o),e&&s))return s}function ce(e,t,n,i,r,o,s){var a,l=n?oe:re;if("undirected"!==t){if(void 0!==r.in&&"out"!==i&&(a=l(e,r.in,o,s),e&&a))return a;if(void 0!==r.out&&"in"!==i&&(i||r.key!==o)&&(a=l(e,r.out,o,s),e&&a))return a}if("directed"!==t&&void 0!==r.undirected&&(a=l(e,r.undirected,o,s),e&&a))return a}var ue=[{name:"neighbors",type:"mixed"},{name:"inNeighbors",type:"directed",direction:"in"},{name:"outNeighbors",type:"directed",direction:"out"},{name:"inboundNeighbors",type:"mixed",direction:"in"},{name:"outboundNeighbors",type:"mixed",direction:"out"},{name:"directedNeighbors",type:"directed"},{name:"undirectedNeighbors",type:"undirected"}];function he(){this.A=null,this.B=null}function de(e,t,n,i,r){for(var o in i){var s=i[o],a=s.source,l=s.target,c=a===n?l:a;if(!t||!t.has(c.key)){var u=r(c.key,c.attributes);if(e&&u)return c.key}}}function pe(e,t,n,i,r){if("mixed"!==t){if("undirected"===t)return de(e,null,i,i.undirected,r);if("string"==typeof n)return de(e,null,i,i[n],r)}var o,s=new he;if("undirected"!==t){if("out"!==n){if(o=de(e,null,i,i.in,r),e&&o)return o;s.wrap(i.in)}if("in"!==n){if(o=de(e,s,i,i.out,r),e&&o)return o;s.wrap(i.out)}}if("directed"!==t&&(o=de(e,s,i,i.undirected,r),e&&o))return o}function me(e,t,n){var i=Object.keys(n),r=i.length,o=0;return new N((function(){var s=null;do{if(o>=r)return e&&e.wrap(n),{done:!0};var a=n[i[o++]],l=a.source,c=a.target;s=l===t?c:l,e&&e.has(s.key)&&(s=null)}while(null===s);return{done:!1,value:{neighbor:s.key,attributes:s.attributes}}}))}function fe(e,t,n,i,r){for(var o,s,a,l,c,u,h,d=i._nodes.values(),p=i.type;!0!==(o=d.next()).done;){var m=!1;if(s=o.value,"undirected"!==p)for(a in l=s.out){c=l[a];do{if(u=c.target,m=!0,h=r(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if("directed"!==p)for(a in l=s.undirected)if(!(t&&s.key>a)){c=l[a];do{if((u=c.target).key!==a&&(u=c.source),m=!0,h=r(s.key,u.key,s.attributes,u.attributes,c.key,c.attributes,c.undirected),e&&h)return c;c=c.next}while(c)}if(n&&!m&&(h=r(s.key,null,s.attributes,null,null,null,null),e&&h))return null}}function ge(e){if(!c(e))throw new H('Graph.import: invalid serialized node. A serialized node should be a plain object with at least a "key" property.');if(!("key"in e))throw new H("Graph.import: serialized node is missing its key.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new H("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.")}function ye(e){if(!c(e))throw new H('Graph.import: invalid serialized edge. A serialized edge should be a plain object with at least a "source" & "target" property.');if(!("source"in e))throw new H("Graph.import: serialized edge is missing its source.");if(!("target"in e))throw new H("Graph.import: serialized edge is missing its target.");if("attributes"in e&&(!c(e.attributes)||null===e.attributes))throw new H("Graph.import: invalid attributes. Attributes should be a plain object, null or omitted.");if("undirected"in e&&"boolean"!=typeof e.undirected)throw new H("Graph.import: invalid undirectedness information. Undirected should be boolean or omitted.")}he.prototype.wrap=function(e){null===this.A?this.A=e:null===this.B&&(this.B=e)},he.prototype.has=function(e){return null!==this.A&&e in this.A||null!==this.B&&e in this.B};var be,ve=(be=255&Math.floor(256*Math.random()),function(){return be++}),we=new Set(["directed","undirected","mixed"]),Ce=new Set(["domain","_events","_eventsCount","_maxListeners"]),Ae={allowSelfLoops:!0,multi:!1,type:"mixed"};function Se(e,t,n){var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}function xe(e,t,n,i,r,o,s,a){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot add a directed edge to an undirected graph. Use the #.addEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot add an undirected edge to a directed graph. Use the #.addEdge or #.addDirectedEdge instead."));if(a&&!c(a))throw new H("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(a,'"'));if(o=""+o,s=""+s,a=a||{},!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var l=e._nodes.get(o),u=e._nodes.get(s);if(!l)throw new V("Graph.".concat(t,': source node "').concat(o,'" not found.'));if(!u)throw new V("Graph.".concat(t,': target node "').concat(s,'" not found.'));var h={key:null,undirected:i,source:o,target:s,attributes:a};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));if(!e.multi&&(i?void 0!==l.undirected[s]:void 0!==l.out[s]))throw new j("Graph.".concat(t,': an edge linking "').concat(o,'" to "').concat(s,"\" already exists. If you really want to add multiple edges linking those nodes, you should create a multi graph by using the 'multi' option."));var d=new q(i,r,l,u,a);e._edges.set(r,d);var p=o===s;return i?(l.undirectedDegree++,u.undirectedDegree++,p&&(l.undirectedLoops++,e._undirectedSelfLoopCount++)):(l.outDegree++,u.inDegree++,p&&(l.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,h.key=r,e.emit("edgeAdded",h),r}function Ee(e,t,n,i,r,o,s,l,u){if(!i&&"undirected"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update a directed edge to an undirected graph. Use the #.mergeEdge/#.updateEdge or #.addUndirectedEdge instead."));if(i&&"directed"===e.type)throw new j("Graph.".concat(t,": you cannot merge/update an undirected edge to a directed graph. Use the #.mergeEdge/#.updateEdge or #.addDirectedEdge instead."));if(l)if(u){if("function"!=typeof l)throw new H("Graph.".concat(t,': invalid updater function. Expecting a function but got "').concat(l,'"'))}else if(!c(l))throw new H("Graph.".concat(t,': invalid attributes. Expecting an object but got "').concat(l,'"'));var h;if(o=""+o,s=""+s,u&&(h=l,l=void 0),!e.allowSelfLoops&&o===s)throw new j("Graph.".concat(t,': source & target are the same ("').concat(o,"\"), thus creating a loop explicitly forbidden by this graph 'allowSelfLoops' option set to false."));var d,p,m=e._nodes.get(o),f=e._nodes.get(s);if(!n&&(d=e._edges.get(r))){if(!(d.source.key===o&&d.target.key===s||i&&d.source.key===s&&d.target.key===o))throw new j("Graph.".concat(t,': inconsistency detected when attempting to merge the "').concat(r,'" edge with "').concat(o,'" source & "').concat(s,'" target vs. ("').concat(d.source.key,'", "').concat(d.target.key,'").'));p=d}if(p||e.multi||!m||(p=i?m.undirected[s]:m.out[s]),p){var g=[p.key,!1,!1,!1];if(u?!h:!l)return g;if(u){var y=p.attributes;p.attributes=h(y),e.emit("edgeAttributesUpdated",{type:"replace",key:p.key,attributes:p.attributes})}else a(p.attributes,l),e.emit("edgeAttributesUpdated",{type:"merge",key:p.key,attributes:p.attributes,data:l});return g}l=l||{},u&&h&&(l=h(l));var b={key:null,undirected:i,source:o,target:s,attributes:l};if(n)r=e._edgeKeyGenerator();else if(r=""+r,e._edges.has(r))throw new j("Graph.".concat(t,': the "').concat(r,'" edge already exists in the graph.'));var v=!1,w=!1;m||(m=Se(e,o,{}),v=!0,o===s&&(f=m,w=!0)),f||(f=Se(e,s,{}),w=!0),d=new q(i,r,m,f,l),e._edges.set(r,d);var C=o===s;return i?(m.undirectedDegree++,f.undirectedDegree++,C&&(m.undirectedLoops++,e._undirectedSelfLoopCount++)):(m.outDegree++,f.inDegree++,C&&(m.directedLoops++,e._directedSelfLoopCount++)),e.multi?d.attachMulti():d.attach(),i?e._undirectedSize++:e._directedSize++,b.key=r,e.emit("edgeAdded",b),[r,!0,v,w]}function _e(e,t){e._edges.delete(t.key);var n=t.source,i=t.target,r=t.attributes,o=t.undirected,s=n===i;o?(n.undirectedDegree--,i.undirectedDegree--,s&&(n.undirectedLoops--,e._undirectedSelfLoopCount--)):(n.outDegree--,i.inDegree--,s&&(n.directedLoops--,e._directedSelfLoopCount--)),e.multi?t.detachMulti():t.detach(),o?e._undirectedSize--:e._directedSize--,e.emit("edgeDropped",{key:t.key,attributes:r,source:n.key,target:i.key,undirected:o})}var Me=function(n){function i(e){var t;if(t=n.call(this)||this,"boolean"!=typeof(e=a({},Ae,e)).multi)throw new H("Graph.constructor: invalid 'multi' option. Expecting a boolean but got \"".concat(e.multi,'".'));if(!we.has(e.type))throw new H('Graph.constructor: invalid \'type\' option. Should be one of "mixed", "directed" or "undirected" but got "'.concat(e.type,'".'));if("boolean"!=typeof e.allowSelfLoops)throw new H("Graph.constructor: invalid 'allowSelfLoops' option. Expecting a boolean but got \"".concat(e.allowSelfLoops,'".'));var i="mixed"===e.type?U:"directed"===e.type?W:Y;h(s(t),"NodeDataClass",i);var r="geid_"+ve()+"_",o=0;return h(s(t),"_attributes",{}),h(s(t),"_nodes",new Map),h(s(t),"_edges",new Map),h(s(t),"_directedSize",0),h(s(t),"_undirectedSize",0),h(s(t),"_directedSelfLoopCount",0),h(s(t),"_undirectedSelfLoopCount",0),h(s(t),"_edgeKeyGenerator",(function(){var e;do{e=r+o++}while(t._edges.has(e));return e})),h(s(t),"_options",e),Ce.forEach((function(e){return h(s(t),e,t[e])})),d(s(t),"order",(function(){return t._nodes.size})),d(s(t),"size",(function(){return t._edges.size})),d(s(t),"directedSize",(function(){return t._directedSize})),d(s(t),"undirectedSize",(function(){return t._undirectedSize})),d(s(t),"selfLoopCount",(function(){return t._directedSelfLoopCount+t._undirectedSelfLoopCount})),d(s(t),"directedSelfLoopCount",(function(){return t._directedSelfLoopCount})),d(s(t),"undirectedSelfLoopCount",(function(){return t._undirectedSelfLoopCount})),d(s(t),"multi",t._options.multi),d(s(t),"type",t._options.type),d(s(t),"allowSelfLoops",t._options.allowSelfLoops),d(s(t),"implementation",(function(){return"graphology"})),t}t(i,n);var r=i.prototype;return r._resetInstanceCounters=function(){this._directedSize=0,this._undirectedSize=0,this._directedSelfLoopCount=0,this._undirectedSelfLoopCount=0},r.hasNode=function(e){return this._nodes.has(""+e)},r.hasDirectedEdge=function(e,t){if("undirected"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&!i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.out.hasOwnProperty(t)}throw new H("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasUndirectedEdge=function(e,t){if("directed"===this.type)return!1;if(1===arguments.length){var n=""+e,i=this._edges.get(n);return!!i&&i.undirected}if(2===arguments.length){e=""+e,t=""+t;var r=this._nodes.get(e);return!!r&&r.undirected.hasOwnProperty(t)}throw new H("Graph.hasDirectedEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.hasEdge=function(e,t){if(1===arguments.length){var n=""+e;return this._edges.has(n)}if(2===arguments.length){e=""+e,t=""+t;var i=this._nodes.get(e);return!!i&&(void 0!==i.out&&i.out.hasOwnProperty(t)||void 0!==i.undirected&&i.undirected.hasOwnProperty(t))}throw new H("Graph.hasEdge: invalid arity (".concat(arguments.length,", instead of 1 or 2). You can either ask for an edge id or for the existence of an edge between a source & a target."))},r.directedEdge=function(e,t){if("undirected"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.directedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.directedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.directedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.directedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||void 0;return i?i.key:void 0}},r.undirectedEdge=function(e,t){if("directed"!==this.type){if(e=""+e,t=""+t,this.multi)throw new j("Graph.undirectedEdge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.undirectedEdges instead.");var n=this._nodes.get(e);if(!n)throw new V('Graph.undirectedEdge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.undirectedEdge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.undirected&&n.undirected[t]||void 0;return i?i.key:void 0}},r.edge=function(e,t){if(this.multi)throw new j("Graph.edge: this method is irrelevant with multigraphs since there might be multiple edges between source & target. See #.edges instead.");e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.edge: could not find the "'.concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V('Graph.edge: could not find the "'.concat(t,'" target node in the graph.'));var i=n.out&&n.out[t]||n.undirected&&n.undirected[t]||void 0;if(i)return i.key},r.areDirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areDirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)},r.areOutNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out},r.areInNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in},r.areUndirectedNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areUndirectedNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"directed"!==this.type&&t in n.undirected},r.areNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&(t in n.in||t in n.out)||"directed"!==this.type&&t in n.undirected},r.areInboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areInboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.in||"directed"!==this.type&&t in n.undirected},r.areOutboundNeighbors=function(e,t){e=""+e,t=""+t;var n=this._nodes.get(e);if(!n)throw new V('Graph.areOutboundNeighbors: could not find the "'.concat(e,'" node in the graph.'));return"undirected"!==this.type&&t in n.out||"directed"!==this.type&&t in n.undirected},r.inDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree},r.outDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree},r.directedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegree: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree},r.undirectedDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegree: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree},r.inboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree),n},r.outboundDegree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.outDegree),n},r.degree=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degree: could not find the "'.concat(e,'" node in the graph.'));var n=0;return"directed"!==this.type&&(n+=t.undirectedDegree),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree),n},r.inDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree-t.directedLoops},r.outDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.outDegree-t.directedLoops},r.directedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.directedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"undirected"===this.type?0:t.inDegree+t.outDegree-2*t.directedLoops},r.undirectedDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.undirectedDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));return"directed"===this.type?0:t.undirectedDegree-2*t.undirectedLoops},r.inboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.inboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree,i+=t.directedLoops),n-i},r.outboundDegreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.outboundDegreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.outDegree,i+=t.directedLoops),n-i},r.degreeWithoutSelfLoops=function(e){e=""+e;var t=this._nodes.get(e);if(!t)throw new V('Graph.degreeWithoutSelfLoops: could not find the "'.concat(e,'" node in the graph.'));var n=0,i=0;return"directed"!==this.type&&(n+=t.undirectedDegree,i+=2*t.undirectedLoops),"undirected"!==this.type&&(n+=t.inDegree+t.outDegree,i+=2*t.directedLoops),n-i},r.source=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.source: could not find the "'.concat(e,'" edge in the graph.'));return t.source.key},r.target=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.target: could not find the "'.concat(e,'" edge in the graph.'));return t.target.key},r.extremities=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.extremities: could not find the "'.concat(e,'" edge in the graph.'));return[t.source.key,t.target.key]},r.opposite=function(e,t){e=""+e,t=""+t;var n=this._edges.get(t);if(!n)throw new V('Graph.opposite: could not find the "'.concat(t,'" edge in the graph.'));var i=n.source.key,r=n.target.key;if(e===i)return r;if(e===r)return i;throw new V('Graph.opposite: the "'.concat(e,'" node is not attached to the "').concat(t,'" edge (').concat(i,", ").concat(r,")."))},r.hasExtremity=function(e,t){e=""+e,t=""+t;var n=this._edges.get(e);if(!n)throw new V('Graph.hasExtremity: could not find the "'.concat(e,'" edge in the graph.'));return n.source.key===t||n.target.key===t},r.isUndirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isUndirected: could not find the "'.concat(e,'" edge in the graph.'));return t.undirected},r.isDirected=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isDirected: could not find the "'.concat(e,'" edge in the graph.'));return!t.undirected},r.isSelfLoop=function(e){e=""+e;var t=this._edges.get(e);if(!t)throw new V('Graph.isSelfLoop: could not find the "'.concat(e,'" edge in the graph.'));return t.source===t.target},r.addNode=function(e,t){var n=function(e,t,n){if(n&&!c(n))throw new H('Graph.addNode: invalid attributes. Expecting an object but got "'.concat(n,'"'));if(t=""+t,n=n||{},e._nodes.has(t))throw new j('Graph.addNode: the "'.concat(t,'" node already exist in the graph.'));var i=new e.NodeDataClass(t,n);return e._nodes.set(t,i),e.emit("nodeAdded",{key:t,attributes:n}),i}(this,e,t);return n.key},r.mergeNode=function(e,t){if(t&&!c(t))throw new H('Graph.mergeNode: invalid attributes. Expecting an object but got "'.concat(t,'"'));e=""+e,t=t||{};var n=this._nodes.get(e);return n?(t&&(a(n.attributes,t),this.emit("nodeAttributesUpdated",{type:"merge",key:e,attributes:n.attributes,data:t})),[e,!1]):(n=new this.NodeDataClass(e,t),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:t}),[e,!0])},r.updateNode=function(e,t){if(t&&"function"!=typeof t)throw new H('Graph.updateNode: invalid updater function. Expecting a function but got "'.concat(t,'"'));e=""+e;var n=this._nodes.get(e);if(n){if(t){var i=n.attributes;n.attributes=t(i),this.emit("nodeAttributesUpdated",{type:"replace",key:e,attributes:n.attributes})}return[e,!1]}var r=t?t({}):{};return n=new this.NodeDataClass(e,r),this._nodes.set(e,n),this.emit("nodeAdded",{key:e,attributes:r}),[e,!0]},r.dropNode=function(e){e=""+e;var t,n=this._nodes.get(e);if(!n)throw new V('Graph.dropNode: could not find the "'.concat(e,'" node in the graph.'));if("undirected"!==this.type){for(var i in n.out){t=n.out[i];do{_e(this,t),t=t.next}while(t)}for(var r in n.in){t=n.in[r];do{_e(this,t),t=t.next}while(t)}}if("directed"!==this.type)for(var o in n.undirected){t=n.undirected[o];do{_e(this,t),t=t.next}while(t)}this._nodes.delete(e),this.emit("nodeDropped",{key:e,attributes:n.attributes})},r.dropEdge=function(e){var t;if(arguments.length>1){var n=""+arguments[0],i=""+arguments[1];if(!(t=l(this,n,i,this.type)))throw new V('Graph.dropEdge: could not find the "'.concat(n,'" -> "').concat(i,'" edge in the graph.'))}else if(e=""+e,!(t=this._edges.get(e)))throw new V('Graph.dropEdge: could not find the "'.concat(e,'" edge in the graph.'));return _e(this,t),this},r.dropDirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropDirectedEdge: it does not make sense to try and drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropDirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e=""+e,t=""+t,"directed");if(!n)throw new V('Graph.dropDirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.dropUndirectedEdge=function(e,t){if(arguments.length<2)throw new j("Graph.dropUndirectedEdge: it does not make sense to drop a directed edge by key. What if the edge with this key is undirected? Use #.dropEdge for this purpose instead.");if(this.multi)throw new j("Graph.dropUndirectedEdge: cannot use a {source,target} combo when dropping an edge in a MultiGraph since we cannot infer the one you want to delete as there could be multiple ones.");var n=l(this,e,t,"undirected");if(!n)throw new V('Graph.dropUndirectedEdge: could not find a "'.concat(e,'" -> "').concat(t,'" edge in the graph.'));return _e(this,n),this},r.clear=function(){this._edges.clear(),this._nodes.clear(),this._resetInstanceCounters(),this.emit("cleared")},r.clearEdges=function(){for(var e,t=this._nodes.values();!0!==(e=t.next()).done;)e.value.clear();this._edges.clear(),this._resetInstanceCounters(),this.emit("edgesCleared")},r.getAttribute=function(e){return this._attributes[e]},r.getAttributes=function(){return this._attributes},r.hasAttribute=function(e){return this._attributes.hasOwnProperty(e)},r.setAttribute=function(e,t){return this._attributes[e]=t,this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.updateAttribute=function(e,t){if("function"!=typeof t)throw new H("Graph.updateAttribute: updater should be a function.");var n=this._attributes[e];return this._attributes[e]=t(n),this.emit("attributesUpdated",{type:"set",attributes:this._attributes,name:e}),this},r.removeAttribute=function(e){return delete this._attributes[e],this.emit("attributesUpdated",{type:"remove",attributes:this._attributes,name:e}),this},r.replaceAttributes=function(e){if(!c(e))throw new H("Graph.replaceAttributes: provided attributes are not a plain object.");return this._attributes=e,this.emit("attributesUpdated",{type:"replace",attributes:this._attributes}),this},r.mergeAttributes=function(e){if(!c(e))throw new H("Graph.mergeAttributes: provided attributes are not a plain object.");return a(this._attributes,e),this.emit("attributesUpdated",{type:"merge",attributes:this._attributes,data:e}),this},r.updateAttributes=function(e){if("function"!=typeof e)throw new H("Graph.updateAttributes: provided updater is not a function.");return this._attributes=e(this._attributes),this.emit("attributesUpdated",{type:"update",attributes:this._attributes}),this},r.updateEachNodeAttributes=function(e,t){if("function"!=typeof e)throw new H("Graph.updateEachNodeAttributes: expecting an updater function.");if(t&&!p(t))throw new H("Graph.updateEachNodeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r=this._nodes.values();!0!==(n=r.next()).done;)(i=n.value).attributes=e(i.key,i.attributes);this.emit("eachNodeAttributesUpdated",{hints:t||null})},r.updateEachEdgeAttributes=function(e,t){if("function"!=typeof e)throw new H("Graph.updateEachEdgeAttributes: expecting an updater function.");if(t&&!p(t))throw new H("Graph.updateEachEdgeAttributes: invalid hints. Expecting an object having the following shape: {attributes?: [string]}");for(var n,i,r,o,s=this._edges.values();!0!==(n=s.next()).done;)r=(i=n.value).source,o=i.target,i.attributes=e(i.key,i.attributes,r.key,o.key,r.attributes,o.attributes,i.undirected);this.emit("eachEdgeAttributesUpdated",{hints:t||null})},r.forEachAdjacencyEntry=function(e){if("function"!=typeof e)throw new H("Graph.forEachAdjacencyEntry: expecting a callback.");fe(!1,!1,!1,this,e)},r.forEachAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new H("Graph.forEachAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!1,!0,this,e)},r.forEachAssymetricAdjacencyEntry=function(e){if("function"!=typeof e)throw new H("Graph.forEachAssymetricAdjacencyEntry: expecting a callback.");fe(!1,!0,!1,this,e)},r.forEachAssymetricAdjacencyEntryWithOrphans=function(e){if("function"!=typeof e)throw new H("Graph.forEachAssymetricAdjacencyEntryWithOrphans: expecting a callback.");fe(!1,!0,!0,this,e)},r.nodes=function(){return"function"==typeof Array.from?Array.from(this._nodes.keys()):D(this._nodes.keys(),this._nodes.size)},r.forEachNode=function(e){if("function"!=typeof e)throw new H("Graph.forEachNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)},r.findNode=function(e){if("function"!=typeof e)throw new H("Graph.findNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return n.key},r.mapNodes=function(e){if("function"!=typeof e)throw new H("Graph.mapNode: expecting a callback.");for(var t,n,i=this._nodes.values(),r=new Array(this.order),o=0;!0!==(t=i.next()).done;)n=t.value,r[o++]=e(n.key,n.attributes);return r},r.someNode=function(e){if("function"!=typeof e)throw new H("Graph.someNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(e((n=t.value).key,n.attributes))return!0;return!1},r.everyNode=function(e){if("function"!=typeof e)throw new H("Graph.everyNode: expecting a callback.");for(var t,n,i=this._nodes.values();!0!==(t=i.next()).done;)if(!e((n=t.value).key,n.attributes))return!1;return!0},r.filterNodes=function(e){if("function"!=typeof e)throw new H("Graph.filterNodes: expecting a callback.");for(var t,n,i=this._nodes.values(),r=[];!0!==(t=i.next()).done;)e((n=t.value).key,n.attributes)&&r.push(n.key);return r},r.reduceNodes=function(e,t){if("function"!=typeof e)throw new H("Graph.reduceNodes: expecting a callback.");if(arguments.length<2)throw new H("Graph.reduceNodes: missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array.");for(var n,i,r=t,o=this._nodes.values();!0!==(n=o.next()).done;)r=e(r,(i=n.value).key,i.attributes);return r},r.nodeEntries=function(){var e=this._nodes.values();return new N((function(){var t=e.next();if(t.done)return t;var n=t.value;return{value:{node:n.key,attributes:n.attributes},done:!1}}))},r.export=function(){var e=this,t=new Array(this._nodes.size),n=0;this._nodes.forEach((function(e,i){t[n++]=function(e,t){var n={key:e};return u(t.attributes)||(n.attributes=a({},t.attributes)),n}(i,e)}));var i=new Array(this._edges.size);return n=0,this._edges.forEach((function(t,r){i[n++]=function(e,t,n){var i={key:t,source:n.source.key,target:n.target.key};return u(n.attributes)||(i.attributes=a({},n.attributes)),"mixed"===e&&n.undirected&&(i.undirected=!0),i}(e.type,r,t)})),{options:{type:this.type,multi:this.multi,allowSelfLoops:this.allowSelfLoops},attributes:this.getAttributes(),nodes:t,edges:i}},r.import=function(e){var t,n,r,o,s,a=this,l=arguments.length>1&&void 0!==arguments[1]&&arguments[1];if(e instanceof i)return e.forEachNode((function(e,t){l?a.mergeNode(e,t):a.addNode(e,t)})),e.forEachEdge((function(e,t,n,i,r,o,s){l?s?a.mergeUndirectedEdgeWithKey(e,n,i,t):a.mergeDirectedEdgeWithKey(e,n,i,t):s?a.addUndirectedEdgeWithKey(e,n,i,t):a.addDirectedEdgeWithKey(e,n,i,t)})),this;if(!c(e))throw new H("Graph.import: invalid argument. Expecting a serialized graph or, alternatively, a Graph instance.");if(e.attributes){if(!c(e.attributes))throw new H("Graph.import: invalid attributes. Expecting a plain object.");l?this.mergeAttributes(e.attributes):this.replaceAttributes(e.attributes)}if(e.nodes){if(r=e.nodes,!Array.isArray(r))throw new H("Graph.import: invalid nodes. Expecting an array.");for(t=0,n=r.length;t<n;t++){ge(o=r[t]);var u=o,h=u.key,d=u.attributes;l?this.mergeNode(h,d):this.addNode(h,d)}}if(e.edges){var p=!1;if("undirected"===this.type&&(p=!0),r=e.edges,!Array.isArray(r))throw new H("Graph.import: invalid edges. Expecting an array.");for(t=0,n=r.length;t<n;t++){ye(s=r[t]);var m=s,f=m.source,g=m.target,y=m.attributes,b=m.undirected,v=void 0===b?p:b;"key"in s?(l?v?this.mergeUndirectedEdgeWithKey:this.mergeDirectedEdgeWithKey:v?this.addUndirectedEdgeWithKey:this.addDirectedEdgeWithKey).call(this,s.key,f,g,y):(l?v?this.mergeUndirectedEdge:this.mergeDirectedEdge:v?this.addUndirectedEdge:this.addDirectedEdge).call(this,f,g,y)}}return this},r.nullCopy=function(e){var t=new i(a({},this._options,e));return t.replaceAttributes(a({},this.getAttributes())),t},r.emptyCopy=function(e){var t=this.nullCopy(e);return this._nodes.forEach((function(e,n){var i=a({},e.attributes);e=new t.NodeDataClass(n,i),t._nodes.set(n,e)})),t},r.copy=function(e){if("string"==typeof(e=e||{}).type&&e.type!==this.type&&"mixed"!==e.type)throw new j('Graph.copy: cannot create an incompatible copy from "'.concat(this.type,'" type to "').concat(e.type,'" because this would mean losing information about the current graph.'));if("boolean"==typeof e.multi&&e.multi!==this.multi&&!0!==e.multi)throw new j("Graph.copy: cannot create an incompatible copy by downgrading a multi graph to a simple one because this would mean losing information about the current graph.");if("boolean"==typeof e.allowSelfLoops&&e.allowSelfLoops!==this.allowSelfLoops&&!0!==e.allowSelfLoops)throw new j("Graph.copy: cannot create an incompatible copy from a graph allowing self loops to one that does not because this would mean losing information about the current graph.");for(var t,n,i=this.emptyCopy(e),r=this._edges.values();!0!==(t=r.next()).done;)xe(i,"copy",!1,(n=t.value).undirected,n.key,n.source.key,n.target.key,a({},n.attributes));return i},r.toJSON=function(){return this.export()},r.toString=function(){return"[object Graph]"},r.inspect=function(){var t=this,n={};this._nodes.forEach((function(e,t){n[t]=e.attributes}));var i={},r={};this._edges.forEach((function(e,n){var o,s=e.undirected?"--":"->",a="",l=e.source.key,c=e.target.key;e.undirected&&l>c&&(o=l,l=c,c=o);var u="(".concat(l,")").concat(s,"(").concat(c,")");n.startsWith("geid_")?t.multi&&(void 0===r[u]?r[u]=0:r[u]++,a+="".concat(r[u],". ")):a+="[".concat(n,"]: "),i[a+=u]=e.attributes}));var o={};for(var s in this)this.hasOwnProperty(s)&&!Ce.has(s)&&"function"!=typeof this[s]&&"symbol"!==e(s)&&(o[s]=this[s]);return o.attributes=this._attributes,o.nodes=n,o.edges=i,h(o,"constructor",this.constructor),o},i}(f.exports.EventEmitter);"undefined"!=typeof Symbol&&(Me.prototype[Symbol.for("nodejs.util.inspect.custom")]=Me.prototype.inspect),[{name:function(e){return"".concat(e,"Edge")},generateKey:!0},{name:function(e){return"".concat(e,"DirectedEdge")},generateKey:!0,type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdge")},generateKey:!0,type:"undirected"},{name:function(e){return"".concat(e,"EdgeWithKey")}},{name:function(e){return"".concat(e,"DirectedEdgeWithKey")},type:"directed"},{name:function(e){return"".concat(e,"UndirectedEdgeWithKey")},type:"undirected"}].forEach((function(e){["add","merge","update"].forEach((function(t){var n=e.name(t),i="add"===t?xe:Ee;e.generateKey?Me.prototype[n]=function(r,o,s){return i(this,n,!0,"undirected"===(e.type||this.type),null,r,o,s,"update"===t)}:Me.prototype[n]=function(r,o,s,a){return i(this,n,!1,"undirected"===(e.type||this.type),r,o,s,a,"update"===t)}}))})),function(e){K.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Node"),0),i(e,n("Source"),1),i(e,n("Target"),2),i(e,n("Opposite"),3)}))}(Me),function(e){Z.forEach((function(t){var n=t.name,i=t.attacher;i(e,n("Edge"),"mixed"),i(e,n("DirectedEdge"),"directed"),i(e,n("UndirectedEdge"),"undirected")}))}(Me),function(e){ee.forEach((function(t){!function(e,t){var n=t.name,i=t.type,r=t.direction;e.prototype[n]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];if(!arguments.length)return function(e,t){if(0===e.size)return[];if("mixed"===t||t===e.type)return"function"==typeof Array.from?Array.from(e._edges.keys()):D(e._edges.keys(),e._edges.size);for(var n,i,r="undirected"===t?e.undirectedSize:e.directedSize,o=new Array(r),s="undirected"===t,a=e._edges.values(),l=0;!0!==(n=a.next()).done;)(i=n.value).undirected===s&&(o[l++]=i.key);return o}(this,i);if(1===arguments.length){e=""+e;var o=this._nodes.get(e);if(void 0===o)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n,i){var r=[];return le(!1,e,t,n,i,(function(e){r.push(e)})),r}(this.multi,"mixed"===i?this.type:i,r,o)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(n,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i,r){var o=[];return ce(!1,e,t,n,i,r,(function(e){o.push(e)})),o}(i,this.multi,r,s,t)}throw new H("Graph.".concat(n,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t,n){if("mixed"===i||"mixed"===this.type||i===this.type){if(1===arguments.length)return ae(!1,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return le(!1,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return ce(!1,i,this.multi,r,a,t,n)}throw new H("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(){var e,t=Array.prototype.slice.call(arguments),n=t.pop();if(0===t.length){var r=0;"directed"!==i&&(r+=this.undirectedSize),"undirected"!==i&&(r+=this.directedSize),e=new Array(r);var s=0;t.push((function(t,i,r,o,a,l,c){e[s++]=n(t,i,r,o,a,l,c)}))}else e=[],t.push((function(t,i,r,o,s,a,l){e.push(n(t,i,r,o,s,a,l))}));return this[o].apply(this,t),e};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop(),n=[];return e.push((function(e,i,r,o,s,a,l){t(e,i,r,o,s,a,l)&&n.push(e)})),this[o].apply(this,e),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(){var e,t,n=Array.prototype.slice.call(arguments);if(n.length<2||n.length>4)throw new H("Graph.".concat(l,": invalid number of arguments (expecting 2, 3 or 4 and got ").concat(n.length,")."));if("function"==typeof n[n.length-1]&&"function"!=typeof n[n.length-2])throw new H("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));2===n.length?(e=n[0],t=n[1],n=[]):3===n.length?(e=n[1],t=n[2],n=[n[0]]):4===n.length&&(e=n[2],t=n[3],n=[n[0],n[1]]);var i=t;return n.push((function(t,n,r,o,s,a,l){i=e(i,t,n,r,o,s,a,l)})),this[o].apply(this,n),i}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="find"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t,n){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return!1;if(1===arguments.length)return ae(!0,this,i,n=e);if(2===arguments.length){e=""+e,n=t;var s=this._nodes.get(e);if(void 0===s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return le(!0,this.multi,"mixed"===i?this.type:i,r,s,n)}if(3===arguments.length){e=""+e,t=""+t;var a=this._nodes.get(e);if(!a)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return ce(!0,i,this.multi,r,a,t,n)}throw new H("Graph.".concat(o,": too many arguments (expecting 1, 2 or 3 and got ").concat(arguments.length,")."))};var s="some"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[s]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,r,o,s,a){return t(e,n,i,r,o,s,a)})),!!this[o].apply(this,e)};var a="every"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[a]=function(){var e=Array.prototype.slice.call(arguments),t=e.pop();return e.push((function(e,n,i,r,o,s,a){return!t(e,n,i,r,o,s,a)})),!this[o].apply(this,e)}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n.slice(0,-1)+"Entries";e.prototype[o]=function(e,t){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();if(!arguments.length)return function(e,t){if(0===e.size)return N.empty();var n="mixed"!==t&&t!==e.type,i="undirected"===t,r=e._edges.values();return new N((function(){for(var e,t;;){if((e=r.next()).done)return e;if(t=e.value,!n||t.undirected===i)break}return{value:{edge:t.key,attributes:t.attributes,source:t.source.key,target:t.target.key,sourceAttributes:t.source.attributes,targetAttributes:t.target.attributes,undirected:t.undirected},done:!1}}))}(this,i);if(1===arguments.length){e=""+e;var n=this._nodes.get(e);if(!n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){var i=N.empty();return"undirected"!==e&&("out"!==t&&void 0!==n.in&&(i=Q(i,ie(n.in))),"in"!==t&&void 0!==n.out&&(i=Q(i,ie(n.out,t?void 0:n.key)))),"directed"!==e&&void 0!==n.undirected&&(i=Q(i,ie(n.undirected))),i}(i,r,n)}if(2===arguments.length){e=""+e,t=""+t;var s=this._nodes.get(e);if(!s)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" source node in the graph.'));if(!this._nodes.has(t))throw new V("Graph.".concat(o,': could not find the "').concat(t,'" target node in the graph.'));return function(e,t,n,i){var r=N.empty();return"undirected"!==e&&(void 0!==n.in&&"out"!==t&&i in n.in&&(r=Q(r,se(n.in,i))),void 0!==n.out&&"in"!==t&&i in n.out&&(t||n.key!==i)&&(r=Q(r,se(n.out,i)))),"directed"!==e&&void 0!==n.undirected&&i in n.undirected&&(r=Q(r,se(n.undirected,i))),r}(i,r,s,t)}throw new H("Graph.".concat(o,": too many arguments (expecting 0, 1 or 2 and got ").concat(arguments.length,")."))}}(e,t)}))}(Me),function(e){ue.forEach((function(t){(function(e,t){var n=t.name,i=t.type,r=t.direction;e.prototype[n]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return[];e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(n,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return Object.keys(n.undirected);if("string"==typeof t)return Object.keys(n[t])}var i=[];return pe(!1,e,t,n,(function(e){i.push(e)})),i}("mixed"===i?this.type:i,r,t)}})(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o="forEach"+n[0].toUpperCase()+n.slice(1,-1);e.prototype[o]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));pe(!1,"mixed"===i?this.type:i,r,n,t)}};var s="map"+n[0].toUpperCase()+n.slice(1);e.prototype[s]=function(e,t){var n=[];return this[o](e,(function(e,i){n.push(t(e,i))})),n};var a="filter"+n[0].toUpperCase()+n.slice(1);e.prototype[a]=function(e,t){var n=[];return this[o](e,(function(e,i){t(e,i)&&n.push(e)})),n};var l="reduce"+n[0].toUpperCase()+n.slice(1);e.prototype[l]=function(e,t,n){if(arguments.length<3)throw new H("Graph.".concat(l,": missing initial value. You must provide it because the callback takes more than one argument and we cannot infer the initial value from the first iteration, as you could with a simple array."));var i=n;return this[o](e,(function(e,n){i=t(i,e,n)})),i}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n[0].toUpperCase()+n.slice(1,-1),s="find"+o;e.prototype[s]=function(e,t){if("mixed"===i||"mixed"===this.type||i===this.type){e=""+e;var n=this._nodes.get(e);if(void 0===n)throw new V("Graph.".concat(s,': could not find the "').concat(e,'" node in the graph.'));return pe(!0,"mixed"===i?this.type:i,r,n,t)}};var a="some"+o;e.prototype[a]=function(e,t){return!!this[s](e,t)};var l="every"+o;e.prototype[l]=function(e,t){return!this[s](e,(function(e,n){return!t(e,n)}))}}(e,t),function(e,t){var n=t.name,i=t.type,r=t.direction,o=n.slice(0,-1)+"Entries";e.prototype[o]=function(e){if("mixed"!==i&&"mixed"!==this.type&&i!==this.type)return N.empty();e=""+e;var t=this._nodes.get(e);if(void 0===t)throw new V("Graph.".concat(o,': could not find the "').concat(e,'" node in the graph.'));return function(e,t,n){if("mixed"!==e){if("undirected"===e)return me(null,n,n.undirected);if("string"==typeof t)return me(null,n,n[t])}var i=N.empty(),r=new he;return"undirected"!==e&&("out"!==t&&(i=Q(i,me(r,n,n.in))),"in"!==t&&(i=Q(i,me(r,n,n.out)))),"directed"!==e&&(i=Q(i,me(r,n,n.undirected))),i}("mixed"===i?this.type:i,r,t)}}(e,t)}))}(Me);var Ie=function(e){function n(t){var n=a({type:"directed"},t);if("multi"in n&&!1!==n.multi)throw new H("DirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("directed"!==n.type)throw new H('DirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),Te=function(e){function n(t){var n=a({type:"undirected"},t);if("multi"in n&&!1!==n.multi)throw new H("UndirectedGraph.from: inconsistent indication that the graph should be multi in given options!");if("undirected"!==n.type)throw new H('UndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),Le=function(e){function n(t){var n=a({multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiGraph.from: inconsistent indication that the graph should be simple in given options!");return e.call(this,n)||this}return t(n,e),n}(Me),Ne=function(e){function n(t){var n=a({type:"directed",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiDirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("directed"!==n.type)throw new H('MultiDirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me),$e=function(e){function n(t){var n=a({type:"undirected",multi:!0},t);if("multi"in n&&!0!==n.multi)throw new H("MultiUndirectedGraph.from: inconsistent indication that the graph should be simple in given options!");if("undirected"!==n.type)throw new H('MultiUndirectedGraph.from: inconsistent "'+n.type+'" type in given options!');return e.call(this,n)||this}return t(n,e),n}(Me);function Pe(e){e.from=function(t,n){var i=a({},t.options,n),r=new e(i);return r.import(t),r}}return Pe(Me),Pe(Ie),Pe(Te),Pe(Le),Pe(Ne),Pe($e),Me.Graph=Me,Me.DirectedGraph=Ie,Me.UndirectedGraph=Te,Me.MultiGraph=Le,Me.MultiDirectedGraph=Ne,Me.MultiUndirectedGraph=$e,Me.InvalidArgumentsGraphError=H,Me.NotFoundGraphError=V,Me.UsageGraphError=j,Me}()},944:(e,t)=>{"use strict";t.Vb=void 0,t.Vb=function(e,t,n){var i=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var i=0,r=e.length,o=t.length,s=Math.floor(Math.max(r,o)/2)-1,a=new Array(r),l=new Array(o),c=0;c<r;c++)for(var u=Math.max(0,c-s);u<=Math.min(o,c+s+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++i,a[c]=l[u]=!0;break}if(0===i)return 0;var h=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(i/r+i/o+(i-(h/=2))/i)/3}(e,t,n),r=0;if(i>.7){for(var o=Math.min(e.length,t.length),s=0;e[s]===t[s]&&s<4&&s<o;)++r,s++;i+=.1*r*(1-i)}return i}},7106:e=>{"use strict";var t=e.exports=function(e,t,i){"function"==typeof t&&(i=t,t={}),n(t,"function"==typeof(i=t.cb||i)?i:i.pre||function(){},i.post||function(){},e,"",e)};function n(e,i,r,o,s,a,l,c,u,h){if(o&&"object"==typeof o&&!Array.isArray(o)){for(var d in i(o,s,a,l,c,u,h),o){var p=o[d];if(Array.isArray(p)){if(d in t.arrayKeywords)for(var m=0;m<p.length;m++)n(e,i,r,p[m],s+"/"+d+"/"+m,a,s,d,o,m)}else if(d in t.propsKeywords){if(p&&"object"==typeof p)for(var f in p)n(e,i,r,p[f],s+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,s,d,o,f)}else(d in t.keywords||e.allKeys&&!(d in t.skipKeywords))&&n(e,i,r,p,s+"/"+d,a,s,d,o)}r(o,s,a,l,c,u,h)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},5072:e=>{"use strict";var t=[];function n(e){for(var n=-1,i=0;i<t.length;i++)if(t[i].identifier===e){n=i;break}return n}function i(e,i){for(var o={},s=[],a=0;a<e.length;a++){var l=e[a],c=i.base?l[0]+i.base:l[0],u=o[c]||0,h="".concat(c," ").concat(u);o[c]=u+1;var d=n(h),p={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(p);else{var m=r(p,i);i.byIndex=a,t.splice(a,0,{identifier:h,updater:m,references:1})}s.push(h)}return s}function r(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,r){var o=i(e=e||[],r=r||{});return function(e){e=e||[];for(var s=0;s<o.length;s++){var a=n(o[s]);t[a].references--}for(var l=i(e,r),c=0;c<o.length;c++){var u=n(o[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}o=l}}},7659:e=>{"use strict";var t={};e.exports=function(e,n){var i=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!i)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");i.appendChild(n)}},540:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},5056:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7825:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var i="";n.supports&&(i+="@supports (".concat(n.supports,") {")),n.media&&(i+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(i+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),i+=n.css,r&&(i+="}"),n.media&&(i+="}"),n.supports&&(i+="}");var o=n.sourceMap;o&&"undefined"!=typeof btoa&&(i+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(o))))," */")),t.styleTagTransform(i,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},1113:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},1407:(e,t,n)=>{"use strict";n.d(t,{R:()=>c});var i=n(4328),r=n(6082),o=n(567),s=n(826),a=n(2738);const l=31;async function c(e,t=!1,n){const a=s.GO.forColumn(e);let c;n??=new Map;const h=a.isHelm()?(0,o.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<h.length;e++)n.has(h[e])||n.set(h[e],`${n.size+1}`);if(a.isHelm())c=await i.functions.call("HELM:getMolFiles",{col:e}),c=function(e,t,n=!1){const i=new Array(e.length);for(let r=0;r<e.length;r++){let o=0,s=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const c=e.get(r);o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1,o=c.indexOf("\n",o)+1;const u=parseInt(c.substring(o,o+3)),h=parseInt(c.substring(o+3,o+6));a+=`M V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){o=c.indexOf("\n",o)+1+l,s=c.indexOf(" ",o);const i=c.substring(o,s);a+=n?`M V30 ${e+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<h;e++){o=c.indexOf("\n",o)+1;const t=parseInt(c.substring(o,o+3).trim()),n=parseInt(c.substring(o+3,o+6).trim());a+=`M V30 ${e+1} ${parseInt(c.substring(o+6,o+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",i[r]=a}return i}(c,n,t);else{c=new Array(e.length);for(let i=0;i<e.length;i++){const e=u(a.getSplitted(i),n,t);c[i]=e}}return r.Column.fromStrings("monomericMols",c)}function u(e,t,n=!1){let i="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";i+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,i+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++){const o=e.getCanonical(r);o!==a._S&&(i+=n?`M V30 ${r+1} R${t.get(o)} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(o)}\n`)}i+="M V30 END ATOM\n",i+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)i+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return i+="M V30 END BOND\n",i+="M V30 END CTAB\n",i+="M END",i}},567:(e,t,n)=>{"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>Ji,SeqActivityCliffsEditor:()=>tr,SeqPaletteCustom:()=>Vi,SequenceSpaceEditor:()=>er,SplitToMonomersEditor:()=>Qi,SubsequenceSearchTopMenu:()=>Pr,_package:()=>Di,activityCliffs:()=>pr,addCopyMenu:()=>qr,alignSequences:()=>vr,applyNotationProviderForCyclized:()=>io,applyNotationProviderForDimerized:()=>ro,bioSubstructureFilter:()=>Dr,compositionAnalysis:()=>wr,compositionAnalysisWidget:()=>rr,convertDialog:()=>Sr,demoBioActivityCliffs:()=>Zr,demoBioAtomicLevel:()=>Xr,demoBioHelmMsaSequenceSpace:()=>Jr,demoBioSequenceSpace:()=>Kr,demoBioSimilarityDiversity:()=>zr,detectMacromoleculeProbe:()=>eo,diversitySearchTopMenu:()=>Nr,diversitySearchViewer:()=>Lr,fastaSequenceCellRenderer:()=>nr,getBioLib:()=>qi,getHelmMonomers:()=>Mr,getMolFromHelm:()=>no,getMonomerLib:()=>zi,getMonomerLibHelper:()=>Bi,getRegion:()=>ur,getRegionApp:()=>Vr,getRegionHelmApp:()=>jr,getRegionPanel:()=>Zi,getRegionTopMenu:()=>dr,getSeqHandler:()=>Ki,getSeqHelper:()=>to,helmPreprocessingFunction:()=>fr,hydrophobPalette:()=>Hi,importBam:()=>Ar,importFasta:()=>Cr,initBio:()=>Wi,libraryPanel:()=>Xi,longSeqTableFasta:()=>Wr,longSeqTableHelm:()=>Yr,longSeqTableSeparator:()=>Ur,macroMolColumnPropertyPanel:()=>ir,macromoleculeDifferenceCellRenderer:()=>sr,macromoleculePreprocessingFunction:()=>mr,manageLibrariesView:()=>Gr,manageMonomerLibraries:()=>kr,manageMonomersView:()=>hr,monomerCellRenderer:()=>xr,multipleSequenceAlignmentDialog:()=>br,saveAsFasta:()=>Fr,sdfToJsonLib:()=>Qr,searchSubsequenceEditor:()=>$r,separatorSequenceCellRenderer:()=>or,sequenceAlignment:()=>ar,sequenceIdentityScoring:()=>Rr,sequenceSimilarityScoring:()=>Or,sequenceSpaceTopMenu:()=>gr,sequenceTooltip:()=>Yi,similaritySearchTopMenu:()=>Tr,similaritySearchViewer:()=>Ir,splitToMonomersTopMenu:()=>_r,testDetectMacromolecule:()=>Er,toAtomicLevel:()=>yr,vdRegionsViewer:()=>cr,webLogoAggApp:()=>Hr,webLogoLargeApp:()=>Br,webLogoViewer:()=>lr});var i,r,o=n(4328),s=n(7389),a=n(6082),l=n(684),c=n(9039);(r=i||(i={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var u=n(1858),h=n(5072),d=n.n(h),p=n(7825),m=n.n(p),f=n(7659),g=n.n(f),y=n(5056),b=n.n(y),v=n(540),w=n.n(v),C=n(1113),A=n.n(C),S=n(7939),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=m(),x.insertStyleElement=w(),d()(S.A,x),S.A&&S.A.locals&&S.A.locals;var E=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};let _=null,M=null;function I(e,t){return e&&""!=e?e:t}class T{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for Distance and UMAP computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter(),null==_))return null;const e=yield _.requestAdapterInfo();return e?I(e.description,I(e.vendor,"No GPU description available")):null}))}().then((e=>{e?(this.useWebGPU.tooltip+=` (${e})`,this.useWebGPU.value=!0):(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class L{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Promise.resolve(),n(934),n(8903);const N="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class ${constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach((n=>{null!=e[n].value&&(t[n]=e[n].value)})),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=s.input.bool("Plot embeddings",{value:!0}),this.clusterEmbeddingsInput=s.input.bool("Cluster embeddings",{value:!0}),this.preprocessingFunctionInputRoot=null,this.methods=[c.c.UMAP,c.c.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=s.inputs([]),this.dbScanSettingsDiv=s.inputs([]),this.preprocessingFuncSettingsDiv=s.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.c.UMAP]:new T,[c.c.T_SNE]:new L},this.dbScanParams=new $,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.GP]}).forEach((e=>{const t=e.options.get(l.n3)??"",n=e.friendlyName??e.name,i=e.options.get(l.C0)??"",r=e.options.get(l._X)??"",o=e.options.get(l.Gi)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!i.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:i?i.split(","):[],units:r?r.split(","):[],distanceFunctions:o?o.split(","):[]})})),this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,items:o.shell.tables,onValueChanged:()=>{this.onTableInputChanged()}}),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=s.input.choice("Method",{value:c.c.UMAP,items:this.methods,onValueChanged:e=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[e])}}),this.methodSettingsIcon=s.icons.settings((()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):s.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=s.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):s.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=s.inputs([]);const i=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=s.input.choice("Encoding function",{value:i[0],items:i,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=s.icons.settings((async()=>{u?s.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=s.input.choice("Similarity",{value:"",items:[]}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find((e=>!!this.columnFunctionsMap[e.name]))??null,t=s.input.column("Column",{table:this.tableInput.value,value:e,onValueChanged:()=>this.onColumnInputChanged(),filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,s.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach((e=>this.colInputRoot.append(e))),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;e&&(this.columnFunctionsMap={},e.columns.toList().forEach((e=>{Object.keys(this.supportedFunctions).forEach((t=>{const n=this.supportedFunctions[t].semTypes,i=this.supportedFunctions[t].types,r=this.supportedFunctions[t].units,o=!n.length||e.semType&&n.includes(e.semType),s=!i.length||i.includes(e.type),a=!r.length||e.meta.units&&r.includes(e.meta.units);o&&s&&a&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))}))})),this.regenerateColInput())}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=s.input.choice("Preprocessing function",{value:t[0],items:t,onValueChanged:()=>{this.onPreprocessingFunctionChanged()}});let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(s.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){s.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=s.input.choice("Similarity",{value:this.availableMetrics[0],items:this.availableMetrics}),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),s.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((e=>this.similarityMetricInputRoot.append(e))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return s.empty(e),Object.keys(t).forEach((n=>{const i=t[n],r="string"===i.type?s.input.string(i.uiName,{value:i.value??"",onValueChanged:e=>{i.value=e}}):"boolean"===i.type?s.input.bool(i.uiName,{value:i.value??!1,onValueChanged:e=>{i.value=e}}):s.input.float(i.uiName,{value:i.value,onValueChanged:e=>{i.value=e}});e.append(r.root),i.disable?(r.enabled=!1,s.tooltip.bind(r.input??r.root,i.disableTooltip??"")):s.tooltip.bind(r.input??r.root,i.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(s.empty(e),t.inputs.length<3)return s.div();const n=t.prepare(),i=await n.buildEditor(s.div());for(let r=2;r<t.inputs.length;r++){const o=t.inputs[r];(this.preprocessingFunctionSettings[o.name]||n.inputParams[t.inputs[r].name].value||o.defaultValue)&&(this.preprocessingFunctionSettings[o.name]=this.preprocessingFunctionSettings[o.name]??n.inputParams[o.name].value??o.defaultValue);const s=i.find((e=>e.property.name===o.name));s&&(null!==this.preprocessingFunctionSettings[o.name]&&void 0!==this.preprocessingFunctionSettings[o.name]&&(s.value=this.preprocessingFunctionSettings[o.name]),s.onChanged.subscribe((e=>{this.preprocessingFunctionSettings[o.name]=e})),e.append(s.root))}return e}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getInput(){return{table:this.tableInput.value.name,col:this.colInput.value.name,methodName:this.methodInput.value,preprocessingFunction:this.preprocessingFunctionInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}getStringInput(){return JSON.stringify(this.getInput())}async applyStringInput(e){try{const t=JSON.parse(e);await this.applyInput(t)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}async applyInput(e){try{const t=this.tableInput.value?.col(e.col);if(!t)throw new Error("Column not found");this.colInput.value=t,this.preprocessingFunctionInput.value=e.preprocessingFunction,this.similarityMetricInput.value=e.similarityMetric,this.plotEmbeddingsInput.value=e.plotEmbeddings,this.clusterEmbeddingsInput.value=e.clusterEmbeddings;const n=this.methodsParams[this.methodInput.value];Object.keys(n).forEach((t=>{null!=e.options[t]&&(this.methodsParams[e.methodName][t].value=e.options[t])})),this.methodInput.value=e.methodName,this.preprocessingFunctionSettings=e.options.preprocessingFuncArgs,await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func)}catch(e){o.shell.error("Error applying input from history"),console.error(e)}}}const R=rxjs.operators;var O=n(6295);const k=e=>null==e;function G(e,t,n,i){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,i)}class F{constructor(e=!0,t=!0){const i=navigator.hardwareConcurrency;this._workerCount=e?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(793),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],i.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],o=[1],s=i.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||o.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(i,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,p=1,m=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const i=Math.floor(n*u),g=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=p;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),p=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-i,opts:r,weights:o,aggregationMethod:s}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:o,min:s,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(h.set(o,i),s<m&&(m=s),a>f&&(f=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-m)/(f-m)})),i(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class D{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,o=[{}],s=[1],a=i.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,o,s,a):0;r<u&&(console.log(`using threshold ${u}`),r=u),o.forEach(((e,t)=>o[t].threshold=r));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(111),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((i,u)=>{const h=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=h&&i({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:p,threshold:r,fnNames:t,opts:o,weights:s,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:o}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),i({i:t,j:r,distance:o,idx:n}))}}));const p=await Promise.all(h),m=p.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(m),g=new Int32Array(m),y=new Float32Array(m);let b=0;for(const e of p)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,i={}){return await this.calcMultiColumn([e],[t],n,[i],[1])}async getKNN(e,t,n=15,i={}){return await this.multiColumnKNN([e],[t],n,[i],[1])}async getThresholdKNN(e,t,n=.8,i={}){return await this.multiColumnThresholdKnn([e],[t],n,[i],[1])}async multiColumnThresholdKnn(e,t,r=.8,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(603),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,threshold:r,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),p=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)p[n]+=t.knnIndexes[n]?.length??0;const m={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(p[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)m.knnDistances[n][p[n]-1]=t.knnDistances[n][e],m.knnIndexes[n][p[n]-1]=t.knnIndexes[n][e],p[n]-=1;return m}async multiColumnKNN(e,t,r=15,o,s,a=i.EUCLIDEAN){if(e.length!==t.length||e.length!==o.length||e.length!==s.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(950),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((i,u)=>{const d=n*c,p=n===this._workerCount-1?l:(n+1)*c;p<=d&&i({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:p,fnNames:t,opts:o,nNeighbours:r,weights:s,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),i({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),p={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<(t.knnDistances[n]?.length??0);++e)G(p.knnDistances[n],p.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return p}async getSampleDistances(e,t,r=[],o,s=i.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(778),n.b))));try{const n=e[0].length*(e[0].length-1)/2,i=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*i,p=l===this._workerCount-1?n:(l+1)*i;a[l].postMessage({values:e,startIdx:d,endIdx:p,sampleLength:u,fnNames:t,opts:r,weights:o,aggregationMethod:s}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),p=d.reduce(((e,t)=>e+t.distance.length),0),m=new Float32Array(p);let f=0;for(const e of d)m.set(e.distance,f),f+=e.distance.length;return m.sort(),m}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,o=i.EUCLIDEAN){try{const i=e.length*(e.length-1)/2,s=await this.getSampleDistances(e,t,n,r,o);return 1-s[Math.floor(7e7/i*s.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,i){const r=[],o=[],s=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=i&&(r.push(l),o.push(c),s.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(o),distance:new Float32Array(s)}}}var B,H,V=n(8774);(H=B||(B={})).none="none",H.bold="bold",H.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,i,r=B.none){var o;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(i),this.visibility=null!==(o=i.visibility)&&void 0!==o?o:new V.A(this.lines.from.length),i.visibility||this.visibility.setAll(!0,!1),i.arrowSize&&(this.arrowWidth=i.arrowSize),this.canvas.onmousedown=e=>{var t;(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)&&(this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY)),-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{var t;this.mouseOverLineId=(null===(t=this.lines)||void 0===t?void 0:t.skipMouseOverDetection)?-1:this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,i,r,o,s,a,l,c,u,h,d,p,m,f,g;const y=this.lines.colors||this.lines.widths||this.lines.opacities||this.lines.drawArrowsArr;y||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const b=this.sp.dataFrame.filter,v=Math.pow(null!==(i=this.lines.shortLineThreshold)&&void 0!==i?i:5,2);for(let e=0;e<this.lines.from.length;e++)if(b.get(this.lines.from[e])&&b.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const n=this.sp.getMarkerSize(this.lines.from[e])/2,i=this.sp.getMarkerSize(this.lines.to[e])/2,b=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let w=null==b?void 0:b.x,C=null==b?void 0:b.y;const A=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let S=null==A?void 0:A.x,x=null==A?void 0:A.y;const E=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),w&&C&&S&&x&&Math.hypot(S-w,x-C)/E>.01){if(y){const t=(null===(r=this.lines.colors)||void 0===r?void 0:r[e])?null===(o=this.lines.colors)||void 0===o?void 0:o[e]:null!==(s=this.lines.color)&&void 0!==s?s:"0,128,0",n=(null===(a=this.lines.opacities)||void 0===a?void 0:a[e])?null===(l=this.lines.opacities)||void 0===l?void 0:l[e]:null!==(c=this.lines.opacity)&&void 0!==c?c:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(u=this.lines.widths)||void 0===u?void 0:u[e])?null===(h=this.lines.widths)||void 0===h?void 0:h[e]:null!==(d=this.lines.width)&&void 0!==d?d:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const b=this.multipleLinesCounts[e];let A=null;if(b){t=this.getLineLength(w,C,S,x);const r=this.getPointOnDistance(w,C,S,x,i,t),o=this.getPointOnDistance(S,x,w,C,n,t);w=r.x,C=r.y,S=o.x,x=o.y,A=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(b,w,C,S,x,e):this.findControlPoint(b,S,x,w,C,e),this.ctx.moveTo(w,C),this.ctx.quadraticCurveTo(A.x,A.y,S,x)}else(!this.lines.skipShortLines||Math.pow(S-w,2)+Math.pow(x-C,2)>v)&&(this.ctx.moveTo(w,C),this.ctx.lineTo(S,x));if((null!==(p=this.lines.drawArrows)&&void 0!==p?p:null===(m=this.lines.drawArrowsArr)||void 0===m?void 0:m.getBit(e))&&(t||(t=this.getLineLength(w,C,S,x)),t>this.arrowWidth)){const e=b?null:this.getPointOnDistance(w,C,S,x,i,t),n=b?A.x:w,r=b?A.y:C;this.canvasArrow(this.ctx,null!==(f=null==e?void 0:e.x)&&void 0!==f?f:w,null!==(g=null==e?void 0:e.y)&&void 0!==g?g:C,n,r)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case B.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case B.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e={};for(let t=0;t<this.lines.from.length;t++){let n=0,i=0;this.lines.from[t]<this.lines.to[t]?(n=this.lines.from[t],i=this.lines.to[t]):(n=this.lines.to[t],i=this.lines.from[t]),e[`${n}|${i}`]?(1===e[`${n}|${i}`].length&&(this.multipleLinesCounts[e[`${n}|${i}`][0]]=1,e[`${n}|${i}`].push(1)),this.multipleLinesCounts[t]=++e[`${n}|${i}`][1]):e[`${n}|${i}`]=[t]}}checkCoordsOnLine(e,t){let n=-1,i=null,r=null;const o=this.sp.dataFrame.filter;for(let s=0;s<this.lines.from.length;s++)if(o.get(this.lines.from[s])&&o.get(this.lines.to[s])&&this.visibility.getBit(s)){const o=this.sp.getMarkerSize(this.lines.from[s])/2,a=this.sp.getMarkerSize(this.lines.to[s])/2,l=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[s]),this.yAxisCol.get(this.lines.from[s])),c=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[s]),this.yAxisCol.get(this.lines.to[s]));if(this.multipleLinesCounts[s]){const n=this.getLineLength(l.x,l.y,c.x,c.y),i=this.getPointOnDistance(l.x,l.y,c.x,c.y,a,n),u=this.getPointOnDistance(c.x,c.y,null==l?void 0:l.x,null==l?void 0:l.y,o,n),h=this.lines.from[s]>this.lines.to[s]?this.findControlPoint(this.multipleLinesCounts[s],i.x,i.y,u.x,u.y,s):this.findControlPoint(this.multipleLinesCounts[s],u.x,u.y,i.x,i.y,s);r=this.calculateDistToCurveLine(s,e,t,i,u,h)}else r=this.calculateDistToStraightLine(e,t,l,c);(!i&&null!==r&&r<5||i&&null!==r&&r<i)&&(i=r,n=s)}return n}calculateDistToStraightLine(e,t,n,i){const r=Math.min(n.x,i.x),o=Math.max(n.x,i.x),s=Math.min(n.y,i.y),a=Math.max(n.y,i.y);return e>=r-2&&e<=o+2&&t>=s-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,i):null}distToStraightLineSegment(e,t,n,i){const r=(e,t,n,i)=>Math.pow(e-n,2)+Math.pow(t-i,2),o=r(n.x,n.y,i.x,i.y);if(0==o)return r(e,t,n.x,n.y);let s=((e-n.x)*(i.x-n.x)+(t-n.y)*(i.y-n.y))/o;return s=Math.max(0,Math.min(1,s)),r(e,t,n.x+s*(i.x-n.x),n.y+s*(i.y-n.y))}calculateDistToCurveLine(e,t,n,i,r,o){const s=Math.min(i.x,r.x,o.x),a=Math.max(i.x,r.x,o.x),l=Math.min(i.y,r.y,o.y),c=Math.max(i.y,r.y,o.y);if(t>=s-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-s,u=c-l;return this.calculateDistToCurveInRect(t,n,i,o,r,e,u)}return null}calculateDistToCurveInRect(e,t,n,i,r,o,s){const a=Math.floor((o+s)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const p=new V.A(a);for(let o=0;o<c.length;o++){const s=o*l,a=Math.pow(1-s,2)*n.x+2*s*(1-s)*i.x+Math.pow(s,2)*r.x,p=Math.pow(1-s,2)*n.y+2*s*(1-s)*i.y+Math.pow(s,2)*r.y,m=Math.abs(e-a),f=Math.abs(t-p),g=m+f;(!d||d>g)&&(d=g),h[o]=Math.max(m,f),c[o]=a,u[o]=p}for(let e=0;e<c.length;e++)h[e]<d&&p.setBit(e,!0,!1);let m=null;for(let n=-1;-1!==(n=p.findNext(n));){const i=Math.hypot(c[n]-e,u[n]-t);(!m||m>i)&&(m=i)}return m}getLineLength(e,t,n,i){return Math.sqrt(Math.pow(n-e,2)+Math.pow(i-t,2))}getPointOnDistance(e,t,n,i,r,o){const s=n-r*((n-e)/o),l=i-r*((i-t)/o);return new a.Point(s,l)}findControlPoint(e,t,n,i,r,o){const s=t+(i-t)/2,l=n+(r-n)/2;let c=s-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(s+d/2*u,l-d/2*c):new a.Point(s-d/2*u,l+d/2*c)}canvasArrow(e,t,n,i,r){const o=Math.atan2(i-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(o-Math.PI/10),n-this.arrowWidth*Math.cos(o-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(o+Math.PI/10),n-this.arrowWidth*Math.cos(o+Math.PI/10))}}const U="dimensionality-reducer-terminate-event";var W,Y,q=n(3629);async function z(e,t,i,r,s,a,l){let c=await async function(e,t,i,r,s,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(234),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:i,options:a,weights:r,aggregationMethod:s});const d=o.events.onCustomEvent(U).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:i}})=>{k(n)||k(i)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,i,t)}}))}(e,i,t,r,s,a,l);return c=c.map((e=>(0,q.S8)(e))),c}(Y=W||(W={})).EUCLIDEAN="EUCLIDEAN",Y.MANHATTAN="MANHATTAN";const K={[W.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[W.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var Z,X;(X=Z||(Z={})).HAMMING="Hamming",X.EUCLIDEAN="Euclidean",X.MANHATTAN="Manhattan",X.TANIMOTO="Tanimoto",X.LEVENSTEIN="Levenshtein",X.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",X.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",X.SOKAL="Sokal",X.COSINE="Cosine",X.ASYMMETRIC="Asymmetric",X.Difference="Difference",X.OneHot="One-Hot";const J={[Z.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[Z.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[Z.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[Z.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[Z.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty; // accounting for the fact that left and right gaps are less costly\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapExtensionPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0 || i == 1 || i == bLength) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0 || j == 1 || j == aLength) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(minLength);\n\n `},[Z.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[Z.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[Z.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[Z.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[Z.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[Z.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},Q={[Z.HAMMING]:e=>Math.ceil(e/30),[Z.EUCLIDEAN]:e=>Math.ceil(e/30),[Z.MANHATTAN]:e=>Math.ceil(e/30),[Z.TANIMOTO]:e=>Math.ceil(e/60),[Z.SOKAL]:e=>Math.ceil(e/60),[Z.COSINE]:e=>Math.ceil(e/60),[Z.ASYMMETRIC]:e=>Math.ceil(e/60),[Z.LEVENSTEIN]:e=>Math.ceil(e*e/60),[Z.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[Z.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[Z.Difference]:e=>1,[Z.OneHot]:e=>Math.ceil(e/40)},ee={STRING:new Set([Z.HAMMING,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.MONOMER_CHEMICAL_DISTANCE,Z.OneHot]),UINT32ARRAY:new Set([Z.HAMMING,Z.EUCLIDEAN,Z.MANHATTAN,Z.MONOMER_CHEMICAL_DISTANCE,Z.LEVENSTEIN,Z.NEEDLEMAN_WUNSCH,Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC,Z.OneHot,Z.Difference]),INT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.OneHot,Z.Difference]),FLOAT32ARRAY:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),NUMBER:new Set([Z.EUCLIDEAN,Z.MANHATTAN,Z.Difference]),BITARRAY:new Set([Z.TANIMOTO,Z.COSINE,Z.SOKAL,Z.ASYMMETRIC])};var te=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function ne(e,t,n,i){return e.map(((e,i)=>`\n fn distanceScript${i}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${i}[aIndex];\n let b = computeInfo.data${i}[bIndex];\n let maxDistance: f32 = ${n};\n ${J[e](t[i],i)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${K[i](e.length)}\n }\n \n `}let ie=0;const re="cliffsDf",oe=new u.Subject,se="activity_difference",ae="SALI_index",le="similarity",ce="line_index",ue=["1_molecule","2_molecule"],he="filterCliffs";async function de(e,t,i,r,l,c,u,h,d,p,m,f,g,y,b,v,w){ie++;const C=c/100;let A,S=!1;const x=f.inputs,I=await f.apply({[x[0].name]:t,[x[1].name]:u,...d.preprocessingFuncArgs??{}});let T=[];if(h===N){const t=await function(e,t,i,r,o,s,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(980),n.b));let h;return u.postMessage({data:e,threshold:t,weights:i,aggregationMethod:r,distanceFns:o,distanceFnArgs:s,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([I.entries],c,[1],"MANHATTAN",[u],[I.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),T=[t.embedX,t.embedY]}else T=await z([I.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[I.options??{}]});if(T.length!==i.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<T.length;++t)e.columns.addNewFloat(i[t]).init((e=>T[t][e]));let L=null;if(d.useWebGPU)try{L=await function(e,t=.8,n,i,r,o){return te(this,void 0,void 0,(function*(){const s=yield function(){return E(this,void 0,void 0,(function*(){if(!_&&(_=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==_))return null;let e=!1;if(M&&(M.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!M||e){const e=1e9,t=_.limits,n=t.maxBufferSize,i=t.maxStorageBufferBindingSize;try{return M=yield _.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(i,e)}}),M}catch(e){return console.error("Failed to create device with required limits",e),M=yield _.requestDevice(),M}}return M}))}();if(!s)return null;const a=Object.values(Z);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(W).includes(i))throw new Error("Invalid aggregation function provided: "+i);const l=1-t;if(o.length!==e.length||o.length!==n.length||o.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=Z.HAMMING,n,i={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,o;let s=null;const a=e.some((e=>"string"==typeof e))?(s="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(s="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(s="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(s="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(s="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(s="INT32ARRAY",e):void 0;if(!a||!s)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!ee[s]||!ee[s].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${s}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=Q[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,p=new d(a.length*u);a.forEach(((e,t)=>{p.set(e,t*u)}));let m="",f=0,g="FLOAT32ARRAY",y=null;if(t===Z.NEEDLEMAN_WUNSCH||t===Z.MONOMER_CHEMICAL_DISTANCE){let e=i.scoringMatrix&&i.alphabetIndexes?Object.keys(i.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!i.alphabetIndexes||!i.scoringMatrix){for(let t=0;t<p.length;t++)p[t]>e&&(e=p[t]);i.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),i.alphabetIndexes={};for(let e=0;e<i.scoringMatrix.length;e++)i.scoringMatrix[e][e]=1,i.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),s=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)s[t][t]=1;const a=i.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(s[e.charCodeAt(0)][t.charCodeAt(0)]=i.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=i.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(o=i.gapExtensionPenalty)&&void 0!==o?o:.6;let l=2;for(let e=0;e<s.length;e++)y.set(s[e],l),l+=s[e].length;m=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===Z.Difference){if(!i.range||"number"!=typeof i.range||i.range<=0){const e=p.reduce(((e,t)=>Math.min(e,t)),p[0]),t=p.reduce(((e,t)=>Math.max(e,t)),p[0]);i.range=t-e}i.range<=0&&(i.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([i.range]),m=`\n range${n}: f32`}const b=p instanceof Int32Array?"i32":p instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:p,sourceArraySize:p.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:m,entryType:s,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,o[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(i=W.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),p=!1;d&&""!=d.trim()||(p=!0,d="\ndummy: f32\n");const m=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*u);h.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(6e3/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/g),x=s.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${m} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${p?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${ne(n,h.map((e=>e.maxEntryLen)),l,i)}\n\n\n `}),I=s.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),T=new Uint32Array(g),L=new Uint32Array(g),N=new Uint32Array(g),$=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),i=t-u*n+Math.floor((n+1)*(n+2)/2);T[e]=O,L[e]=R,N[e]=i,$[e]=n,R=n,O=i}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),G=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,D=k*Uint32Array.BYTES_PER_ELEMENT;let B=D;const H=15&D;0!==H&&(B+=16-H);const V=s.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),j=V.getMappedRange();let U=0;new Uint32Array(j,U,g).set(T),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set(L),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set(N),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,g).set($),U+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(j,U,f.length).set(f),U+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(j,U,c).set(r),U+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(j,U,n).set(e.flatSourceArray),U+=n*t.BYTES_PER_ELEMENT}V.unmap();const Y=G*Uint32Array.BYTES_PER_ELEMENT;let q=Y;const z=15&Y;0!==z&&(q+=16-z),q=Math.max(q,16);const K=s.createBuffer({label:"supp info buffer",size:q,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),X=K.getMappedRange();let J=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(X,J,e.suppInfoBuffer.length).set(e.suppInfoBuffer),J+=e.suppInfoBuffer.byteLength);0===J&&new Uint32Array(X,0,4).set([1,1,1,1]),K.unmap();const te=302e4*Uint32Array.BYTES_PER_ELEMENT;let ie=te;const re=15&te;0!==re&&(ie+=16-re);const oe=s.createBuffer({label:"results buffer",size:ie,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),se=s.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:V}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:oe}}]}),ae=s.createBuffer({label:"results out buffer",size:oe.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=s.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,se),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(oe,0,ae,0,ae.size);const n=e.finish();s.queue.submit([n]),yield s.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const i=ae.getMappedRange();let r=0;const o=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(i,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(i,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(i,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(i,r,g).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),p=new Float32Array(u);let m=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(o.subarray(e*y,e*y+t),m),d.set(a.subarray(e*y,e*y+t),m),p.set(l.subarray(e*y,e*y+t),m),m+=t)}le.push(h),ce.push(d),ue.push(p),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),pe=new Uint32Array(de),me=new Uint32Array(de),fe=new Float32Array(de);let ge=0;for(let e=0;e<le.length;e++)pe.set(le[e],ge),me.set(ce[e],ge),fe.set(ue[e],ge),ge+=le[e].length;return V.destroy(),K.destroy(),oe.destroy(),ae.destroy(),{i:pe,j:me,distance:fe}}))}([I.entries],C,[u],W.MANHATTAN,[1],[I.options??{}])}catch(e){console.error(e)}L||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),L=await(new D).calc(I.entries,u,C,I.options));const $=await async function(e,t){const n=e.distance.map(((n,i)=>{const r=Math.abs(t.get(e.i[i])-t.get(e.j[i]));return 0!=n?r/n:1/0})),i=e.distance.map((e=>1-e)),r=e.i,o=e.j,s=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{s.set(e.i[n],!0),s.set(e.j[n],!0)})),{simVals:i,saliVals:n,n1:r,n2:o,cliffsBitSet:s}}(L,l),P=function(e,t,n,i,r,o,s){const l=new Array(e).fill(0);for(let e=0;e!=i.length;++e)n[e]!=1/0&&(s.get(i[e])>s.get(r[e])?l[i[e]]+=n[e]:l[r[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${i[0].substring(i[0].lastIndexOf("_"))}`,$.saliVals,$.n1,$.n2,0,l);e.columns.add(P);const O=$.cliffsBitSet,k=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}($.saliVals),G=.8/(k.max-k.min),F=w?o.shell.view("Browse").preview:o.shell.getTableView(e.name),H=F.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:i[0],yColumnName:i[1],size:P.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),V=function(e,t,n,i,r,o,s,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-s.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return ue.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),o),u.col(e).semType=r})),u.columns.addNewFloat(se).init((e=>Math.abs(i.get(c.from[e])-i.get(c.to[e])))),u.columns.addNewInt(ce).init((e=>e)),u.columns.addNewFloat(ae).init((e=>t.saliVals[e])),u.columns.addNewFloat(le).init((e=>t.simVals[e])),u.name=`${re}${ie}`,{lines:c,linesDf:u}}(e,$,t,l,p,m,k,G);V.lines.skipMultiLineCalculation=!0,V.linesDf.col(ae).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(H,i[0],i[1],V.lines,B.none),Y=b?b(V.linesDf,ue).sort([ae],[!1]):V.linesDf.plot.grid().sort([ae],[!1]);Y.col(ce)&&(Y.col(ce).visible=!1),e.temp[".cliffsDfGrid"]=Y;const q=s.button(`${V.linesDf.rowCount} cliffs`,(()=>{w&&F.addViewer(Y),F.dockManager.dock(Y,"down",null,"Activity cliffs",v??.2)}));q.classList.add("scatter_plot_link","cliffs_grid"),H.root.append(q);const K=s.input.toggle("Show only cliffs",{value:!1,onValueChanged:t=>{t?(H.dataFrame.setTag(he,i[0]),e.filter.and(O),oe.next(i[0])):(H.dataFrame.setTag(he,""),e.filter.setAll(!0),oe.next(""))}});K.root.classList.add("scatter_plot_link","show_only_cliffs"),H.root.append(K.root),oe.subscribe((e=>{K.enabled=""===e||e===i[0]}));let X=!1;H.onEvent("d4-before-draw-scene").subscribe((t=>{X?X=!1:K.value&&(setTimeout((()=>{e.filter.and(O)}),100),X=!0)}));const J=o.events.onViewerClosed.subscribe((e=>{e.args.viewer===H&&(F.dockManager.close(Y.root),J.unsubscribe(),F.subs=F.subs.filter((e=>e!==J)))}));return F.subs.push(J),V.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<V.linesDf.rowCount;e++)V.lines.widths[e]=e===V.linesDf.currentRowIdx?3:1;U.linesToRender=V.lines;const n=V.linesDf.currentCol&&V.linesDf.currentCol.name===ue[1]?V.lines.to:V.lines.from,r=-1!==V.linesDf.currentRowIdx?V.linesDf.currentRowIdx:null;if(H.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=V.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,i,r,o){const s=Math.abs(n-r),a=Math.abs(i-o),l=e/s,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,p=(n<r?n:r)+s/2-h/2,m=(i>o?i:o)-a/2+d/2;return{zoomLeft:p,zoomRight:p+h,zoomTop:m,zoomBottom:m-d}}(H.viewport.width,H.viewport.height,H.dataFrame.get(i[0],V.lines.from[n]),H.dataFrame.get(i[1],V.lines.from[n]),H.dataFrame.get(i[0],V.lines.to[n]),H.dataFrame.get(i[1],V.lines.to[n]));H.zoom(a,u,c,h),K.value?e.filter.and(O):!0===K.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,i,r,a,l,c,u){const h=t.getPane("Cliff Details");s.empty(h.root);const d=u({points:[n,i],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{o.shell.o=t.root}),500)}(e,A,V.lines.from[r],V.lines.to[r],r,t,l,V.linesDf.get(ae,r),y);const n=H.dataFrame.getSortedOrder(F.grid.sortByColumns,F.grid.sortTypes);F.grid.scrollToCell(t.name,n.indexOf(H.dataFrame.currentRowIdx))}),1e3)}})),V.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<V.linesDf.rowCount;e++){const n=V.linesDf.selection.get(e);n&&(t.set(V.lines.from[e],!0),t.set(V.lines.to[e],!0)),V.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),U.linesToRender=V.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<V.lines.colors.length;e++)V.lines.colors[e]="0,128,0";U.linesToRender=V.lines})(Y.dataFrame))})),U.lineClicked.subscribe((t=>{if(S=!0,U.currentLineId=t.id,-1!==t.id){const n=V.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),V.linesDf.selection.copyFrom(n)):(V.linesDf.currentRowIdx!==t.id&&(V.linesDf.currentRowIdx=t.id,e.currentRowIdx=V.lines.from[t.id]),V.linesDf.selection.copyFrom(n));const i=V.linesDf.getSortedOrder(Y.sortByColumns,Y.sortTypes);Y.scrollToCell(ue[0],i.indexOf(t.id))}),500)}})),U.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&s.tooltip.show(g({lineId:n.id,points:[V.lines.from[n.id],V.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),H.addProperty("similarityLimit","double",C),A=function(){const e=s.accordion(),t=s.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(s.span([t,s.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>s.divText("Cliff has not been selected")),!0),o.shell.o=e.root,e}(),H}var pe,me=n(2003),fe=n(826),ge=n(3516),ye=n(6718),be=n(2738),ve=n(3077);!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var we=n(9192);class Ce{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class Ae extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numericalNoDateTime;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(t),filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=s.input.int("Similarity cutoff",{value:80}),this.methodsParams[N]=new Ce}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){s.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=s.input.column("Activities",{table:this.tableInput.value,value:a.Utils.firstOrNull(e),filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return s.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}getInput(){return{...super.getInput(),activityCol:this.activitiesInput.value.name,simThreshold:this.similarityInput.value}}async applyInput(e){super.applyInput(e),this.activitiesInput.value=this.tableInput.value.col(e.activityCol),this.similarityInput.value=e.simThreshold}}var Se=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function xe(e,t,i){return Se(this,void 0,void 0,(function*(){return new Promise((function(r,o){const s=new Worker(new URL(n.p+n.u(705),n.b));s.postMessage({distMatArray:e,n:t,methodCode:i}),s.onmessage=({data:{error:e,clusterMatrix:t}})=>{s.terminate(),e?o(e):r(t)}}))}))}var Ee,_e,Me,Ie=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function Te(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function Le(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}n(5540),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(Ee||(Ee={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(_e||(_e={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(Me||(Me={})),Object.prototype.toString;var Ne=n(6873),$e=n(4356),Pe=n(6717),Re=n(4870),Oe=n(1991),ke=n.n(Oe),Ge=n(9322);const Fe="#808080",De="rgb(0,0,0)",Be=Ge.zS;var He,Ve;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(He||(He={})),function(e){e.MSA="MSA",e.classic="classic"}(Ve||(Ve={}));const je=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=Ve.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function Ue(e,t,n,i,r,o,s){var a,l,c;const u=Object.assign(Object.assign({},je),s);s.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let h=t.substring(0),d=u.last?"":u.separator;u.drawStyle===Ve.MSA&&(d="");let p=!0,m=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(p=u.gridCell.cell.column.temp["color-code"]??!0,m=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];m&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=h==e?.3:u.transparencyRate),m&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=h!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(h=Be(h,u.maxLengthOfMonomer));const g=h+d;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));let b=u.monomerTextSizeMap[h].width;const v=o/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));const w=u.monomerTextSizeMap[d].width;function C(t,r){const o=p?u.color:De;e.fillStyle=o,e.globalAlpha=u.transparencyRate,u.drawStyle===Ve.classic&&(e.fillText(h,n+t,i+v),e.fillStyle=Fe,e.fillText(d,n+r,i+v)),u.drawStyle===Ve.MSA&&e.fillText(h,n+t,i+v)}y=y.width,u.drawStyle===Ve.MSA&&(b=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const A=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>r)return C(A,A+b),n+A+b+w;{const e=(r-y)/2;return C(e,e+b),n+A+e+b}}var We=n(6882),Ye=n(4152);const qe={[me.YI.DNA]:"RNA",[me.YI.RNA]:"RNA",[me.YI.PT]:"PEPTIDE",[me.YI.UN]:"PEPTIDE"};var ze=n(6642);const Ke={true:"1",false:"0"};var Ze=n(4139);const Xe="rgb(100,100,100)",Je=me.zS;function Qe(e,t,n,i,r){return e?Math.max(Math.min(e.canvas.width/r-n,i)):Math.max(t.canvas.width/r-n,0)}function et(e){const t=!ke().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],i=t?"":" ";for(const[t,r]of ke().enumerate(e)){let o=t;r<e.length&&(o+=`${t?"":"-"}${i}`),n.push(o)}return[n,t]}class tt extends a.GridCellRenderer{padding=5;get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const[n,i,r]=(0,ze.h)(e),o=r.rendererBack;if(!o)return;const a=e.bounds,l=t.offsetX-e.gridColumn.left+(e.gridColumn.left-a.x),c=o.getPosition(e.tableRowIndex,l,a.width),u=fe.GO.forColumn(i).getSplitted(e.tableRowIndex).canonicals;if(null!==c&&c<u.length){const e=u[c],n=[];let r=o._monomerStructureMap[e];r=o._monomerStructureMap[e]=(()=>{const t=fe.GO.forColumn(i).alphabet??me.YI.UN,n=qe[t],r=zi();return r?r.getTooltip(n,e):s.divText("Monomer library is not available")})(),n.push(r),s.tooltip.show(s.divV(n),t.x+16,t.y+16)}else s.tooltip.hide()}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,[l,c,u]=(0,ze.h)(o);if(!c)return;const h=c.temp;let d=0,p=(Di.properties?Di.properties.maxMonomerLength:4)??50;if(He.maxMonomerLength in c.tags){const e=parseInt(c.getTag(He.maxMonomerLength));p=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in h){const e=h[".mm.cellRenderer.maxMonomerLength"];p=!isNaN(e)&&e?e:50}const[m,f,g]=(0,ze.h)(o);let y=g.rendererBack;y||(y=g.rendererBack=new We.J(l,c,Di.logger,p,(()=>{const e=fe.GO.forColumn(c);return{seqHandler:e,monomerCharWidth:7,separatorWidth:e.isMsa()?8:d,monomerToShort:Je}}))),e.save();try{c.temp[".mm.cellRenderer.settingsChanged"]!==Ke.true&&y.monomerLengthLimit==p||(d=h[".mm.cellRenderer.gapLength"]??d,y.setMonomerLengthLimit(p),y.setSeparatorWidth(y.isMsa()?8:d),c.temp[".mm.cellRenderer.settingsChanged"]=Ke.false);const[s,u]=y.getCellMonomerLengths(o.tableRowIndex,i),m=(s.length,o.cell.value,o.cell.rowIndex),f=c.getTag(me.gp.alphabet),g=50;i=Qe(l?.grid,e,t,i,a),e.beginPath(),e.rect(t+this.padding,n+this.padding,i-this.padding-1,r-2*this.padding),e.clip(),e.font="12px monospace",e.textBaseline="top";const b=c.meta.units,v=c.getTag(me.gp.aligned),w=(0,me.ny)(f),C=c.getTag(me.gp.separator)??"",A=y.props.separatorWidth+1*y.props.monomerCharWidth,S=Math.ceil(i/A),x=fe.GO.forColumn(c),E=h["reference-sequence"],_=h["current-word"];_&&-1===c?.dataFrame?.currentRowIdx&&(h["current-word"]=null);const M=(()=>{const e=x.getSplitter(S);return ke()(e(null!=E&&""!=E?E:_??"").originals).toArray()})(),I=x.getSplitted(m);let T=Xe,L=Ve.classic;v&&v.includes("MSA")&&b==me.Hi.SEPARATOR&&(L=Ve.MSA);const N=Math.min(I.length,S);for(let s=0;s<N;++s){const a=I.getOriginal(s);T=w.get(a),e.fillStyle=Xe;const l={color:T,pivot:0,left:!0,transparencyRate:1,separator:C,last:s===I.length-1,drawStyle:L,maxWord:u,wordIdx:s,gridCell:o,referenceSequence:M,maxLengthOfMonomer:p,monomerTextSizeMap:y._monomerLengthMap,logger:Di.logger};if(Ue(e,a,t+this.padding,n,i,r,l),g>i)break}}catch(e){const[t,n]=(0,we.AP)(e);y.logger.error(t,void 0,n),y.errors.push(e)}finally{e.restore()}}}class nt extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ze.uF.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,i,r,o,s){const a=window.devicePixelRatio,l=o.grid,c=o.cell,u=o.tableColumn,h=c.value??"",d=u.tags[me.gp.separator],p=u.meta.units;i=Qe(l,e,t,i,a);const[m,f]=h.split("#"),g=(0,Ge.Iv)(p,d);it(e,t,n,i,r,ke()(g(m).canonicals).toArray(),ke()(g(f).canonicals).toArray(),p)}}function it(e,t,n,i,r,o,s,a,l,c){if(o.length!==s.length){const e=function(e,t){let n=0,i=0;const r=e.length>t.length?e:t,o=e.length>t.length?t:e;for(let e=0;e<o.length;e++)r[e]===o[e]&&n++;const s=r.length-o.length;for(let e=r.length-1;e>s;e--)r[e]===o[e-s]&&i++;const a=new Array(Math.abs(e.length-t.length)).fill(fe.b9[me.Hi.FASTA]);function l(e){return n>i?e.concat(a):a.concat(e)}return e.length>t.length?t=l(ke()(t).toArray()):e=l(ke()(e).toArray()),{subParts1:e,subParts2:t}}(o,s);o=e.subParts1,s=e.subParts2}const u=e.measureText(et(o).join("")),h=e.measureText(et(s).join("")),d=Math.max(u.width,h.width);l&&(i=d+4*o.length,e.canvas.width=d+4*o.length);let p=Math.max(t,t+(i-(d+4*o.length))/2)+5;const m=Math.max(n,n+(r-28)/2);e.save(),e.beginPath(),e.rect(t,n,l?d+4*o.length:i,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Ye.oT.Color;"HELM"!==a&&(f=(0,me.ny)(a.substring(a.length-2)));for(let t=0;t<o.length;t++){const n=o[t],a=s[t],l=f.get(n);if(n!=a){const o=f.get(a),s=Ue(e,n,p,m-7,i,r,{color:l,pivot:0,left:!0}),u=Ue(e,a,p,m+7,i,r,{color:o,pivot:0,left:!0});p=Math.max(u,s),c&&(c[t]=rt(n,a,l,o,m,7,r))}else p=Ue(e,n,p,m,i,r,{color:l,pivot:0,left:!0,transparencyRate:.5});p+=4}e.restore()}function rt(e,t,n,i,r,o,s){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(et([e]).join("")).width,u=l.measureText(et([t]).join("")).width,h=Math.max(c,u);return a.height=s,a.width=h+4,l.font="12px monospace",l.textBaseline="top",Ue(l,e,0,r-o,h,s,{color:n,pivot:0,left:!0}),Ue(l,t,0,r+o,h,s,{color:i,pivot:0,left:!0}),a}var ot,st=n(8070),at=n(4326);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ot||(ot={}));const lt=new class{constructor(){this.regionTypes=[ot.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=at.fH.Entropy,this.filterSource=at.Fo.filterSource}};var ct=n(7602),ut=n(8047);const ht=ot;var dt,pt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(dt||(dt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(pt||(pt={}));const mt=lt;class ft extends a.JsViewer{viewed=!1;regionsFg=null;regionsRoot=null;isOpened=!1;panelNode=null;regions=[];regionTypes;chains;skipEmptyPositions;fitWidth;positionWidth;positionHeight;filterSource;constructor(){super(),this.skipEmptyPositions=this.bool(pt.skipEmptyPositions,mt.skipEmptyPositions,{category:dt.DATA}),this.regionTypes=this.stringList(pt.regionTypes,mt.regionTypes,{category:dt.DATA,choices:Object.values(ht).filter((e=>e!=ht.Unknown))}),this.chains=this.stringList(pt.chains,mt.chains,{category:dt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(pt.fitWidth,mt.fitWidth,{category:dt.LAYOUT}),this.positionWidth=this.float(pt.positionWidth,mt.positionWidth,{category:dt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(pt.positionHeight,mt.positionHeight,{category:dt.LAYOUT,choices:Object.keys(at.fH)}),this.filterSource=this.string(pt.filterSource,mt.filterSource,{category:dt.BEHAVIOR,choices:Object.values(at.lT)}),this.viewSyncer=new ct.g(Di.logger)}static viewerCounter=-1;viewerId=++ft.viewerCounter;viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case pt.regionTypes:case pt.chains:this.setData(this.regions)}switch(e.name){case pt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case pt.fitWidth:case pt.positionWidth:this.calcSize();break;case pt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.positionHeight]:this.positionHeight});this.calcSize();break;case pt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;Di.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}viewSyncer;setDataInProgress=!1;host=null;filterSourceInput;mainLayout=null;logos=[];viewSubs=[];async destroyView(e){Di.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&s.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){Di.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),i=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const o=t.find((t=>t.order==n[e]&&t.chain==r));i.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(i);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=s.table(this.chains,(e=>[...n.length>0?[s.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",s.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=s.input.choice("Data source",{value:this.filterSource,items:Object.values(at.lT),onValueChanged:this.filterSourceInputOnValueChanged.bind(this)}),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=s.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(s.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Di.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSizeRequested=!1;calcSize(){Di.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,i=9,r=(this.root.clientWidth-e-(this.logos.length-1)*i-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[ut.n5.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ut.n5.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(pt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[ut.n5.filterSource]:this.filterSource})}}}))}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,st.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}var gt=n(6625),yt=n(6863);async function bt(e,t,n="Morgan"){const i=e.length,r=fe.GO.forColumn(e),o=Array(i);let s=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<i;t++){if(null===l[c[t]]||e.isNone(t)){o[t]=null;continue}o[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const i=n.getCanonical(e);a.has(i)||(a.set(i,String.fromCharCode(s)),s++),o[t]+=a.get(i)}}let u={};if(t===yt.Z.MONOMER_CHEMICAL_DISTANCE||t===yt.Z.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,ye.A7)(e,n),i={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{i[a.get(e)]=t}));const r=o.reduce(((e,t)=>Math.max(e,t.length)),0);u={scoringMatrix:t.scoringMatrix,alphabetIndexes:i,maxLength:r}}return{seqList:o,options:u}}var vt=n(2780),wt=n(8115);function Ct(e){const t=s.divH([],{style:{gap:"10px"}}),n=s.divV([s.divText(e.seqCol.name),s.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const i=s.divText(e.activityCol.get(n).toFixed(2));i.style.display="flex",i.style.justifyContent="left",i.style.paddingLeft="30px",t.append(s.divV([s.divText(e.seqCol.get(n)),i]))})),t}function At(e){const t=s.div();t.append(s.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,i)=>{n[i]=e.activityCol.get(t)}));const i={},r=fe.GO.forColumn(e.seqCol),o=xt(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),r.units,i);return t.append(s.div(o,{style:{width:"300px",overflow:"scroll"}})),t.append(Et(i)),t.append(St("Activity delta",Math.abs(n[0]-n[1]))),t.append(St("Cliff",e.sali)),t}function St(e,t){return s.divH([s.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),s.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function xt(e,t,n,i){const r=document.createElement("canvas"),o=r.getContext("2d");return r.height=30,it(o,0,0,0,30,ke()(e.canonicals).toArray(),ke()(t.canonicals).toArray(),n,!0,i),r}function Et(e){const t=s.div();if(Object.keys(e).length>0){const n=s.divV([]);n.append(s.divH([s.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),s.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(s.divH([s.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function _t(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.meta.units=e.col(t[0]).meta.units,n.setTag(me.gp.separator,e.col(t[0]).getTag(me.gp.separator)),e.columns.add(n);const i=e.plot.grid();return i.col(t[0]).visible=!1,i.col(t[1]).visible=!1,i}class Mt extends a.JsViewer{name="";distanceMetric;limit;fingerprint;metricsProperties=["distanceMetric","fingerprint"];fingerprintChoices=["Morgan","Pattern"];moleculeColumn;moleculeColumnName;initialized=!1;tags=[a.TAGS.UNITS,me.gp.aligned,me.gp.separator,me.gp.alphabet];preComputeDistanceMatrix=!1;constructor(e){super(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",O.iS[0],{choices:O.iS}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(s.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}computeRequested;renderPromise=Promise.resolve();render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(o.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var It=n(1407),Tt=n(439);const Lt={gapPenalty:1,matchScore:1,gapSymbol:fe.b9[Tt.Hi.FASTA],localAlignment:!1};class Nt extends Mt{cutoff;hotSearch;similarColumnLabel;sketchedMolecule="";curIdx=0;molCol=null;idxs=null;scores=null;gridSelect=!1;targetMoleculeIdx=0;computeCompleted=new u.Subject;distanceMatrixComputed=!1;mmDistanceMatrix;knn;kPrevNeighbors=0;demo;constructor(e){super("similarity"),this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null),this.demo=e}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=fe.GO.forColumn(this.moleculeColumn);await(e.isHelm()?this.computeByChem():this.computeByMM());const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=a.Column.string(t,this.idxs.length).init((e=>this.moleculeColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.moleculeColumn.getTag(e))));const n=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const i=n.plot.grid();i.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));i.cell("score",r).cell.value=null,(this.demo?o.shell.view("Browse").preview:o.shell.v).grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),(0,Re.K)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,It.R)(this.moleculeColumn),t=(a.DataFrame.fromColumns([e]),await o.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:e,molecule:e.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=t.getCol("indexes"),this.scores=t.getCol("score")}async computeByMM(){const e=this.moleculeColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await bt(this.moleculeColumn,yt.Z.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new D).getKNN(n,yt.Z.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=s.div(),n={},i=this.molCol?.name,r=e.col(i),a=fe.GO.forColumn(this.moleculeColumn),l=fe.GO.forColumn(r),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const i={...Lt,...n},r=e.length,o=t.length,s=Array(r+1).fill(0).map((()=>Array(o+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<o+1;r++)s[n][r]=Math.max(0,s[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?i.matchScore:-i.matchScore),s[n-1][r]-i.gapPenalty,s[n][r-1]-i.gapPenalty),s[n][r]>=a&&(a=s[n][r],l=[n,r]);let c=i.localAlignment?l[0]:r,u=i.localAlignment?l[1]:o,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(s[c-1][u-1],s[c-1][u],s[c][u-1]);s[c][u]==s[c-1][u-1]+i.matchScore&&n==s[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):s[c][u]==s[c-1][u]-i.gapPenalty?(d.push(i.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):s[c][u]==s[c][u-1]-i.gapPenalty?(h.push(i.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...Array.from(e.canonicals).splice(0,c),...h.reverse(),...i.localAlignment?Array.from(e.canonicals).splice(l[0],r):[]],d=[...Array.from(t.canonicals).splice(0,u),...d.reverse(),...i.localAlignment?Array.from(t.canonicals).splice(l[1],o):[]];const p=c,m=u;return p>m?d=[...new Array(p-m).fill(i.gapSymbol.valueOf()),...d]:h=[...new Array(m-p).fill(i.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(i.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(i.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Ge.Mu(h,i.gapSymbol),seq2Splitted:new Ge.Mu(d,i.gapSymbol)}}(c,u),d=xt(h.seq1Splitted,h.seq2Splitted,l.units,n);t.append(s.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(s.divV([s.divText("Different sequence length:",{style:{fontWeight:"bold"}}),s.divText(`target: ${c.length} monomers`),s.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(Et(n));const p=s.accordion(),m=s.element("i");m.className="grok-icon svg-icon svg-view-layout",p.addTitle(s.span([m,s.label("Similarity search")])),p.addPane("Differences",(()=>t),!0),o.shell.o=p.root}}class $t extends Mt{diverseColumnLabel;renderMolIds=null;columnNames=[];computeCompleted=new u.Subject;constructor(){super("diversity"),this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.moleculeColumn){const e=fe.GO.forColumn(this.moleculeColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.moleculeColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.moleculeColumn.getTag(e))));const i=a.DataFrame.fromColumns([n]);i.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Re.K)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,It.R)(this.moleculeColumn);a.DataFrame.fromColumns([e]),this.renderMolIds=await o.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await bt(this.moleculeColumn,yt.Z.LEVENSHTEIN)).seqList,t=new F(!0,!1),n=await t.calc(e,yt.Z.LEVENSHTEIN);t.terminate();const i=this.moleculeColumn.length,r=(o=i,(e,t)=>o*e+t-Math.floor((e+2)*(e+1)/2));var o;this.renderMolIds=function(e,t,n){function i(e,t){let n=null,i=null;for(const r of e){const e=t(r);(null==i||e>i)&&(n=r,i=e)}return n}const r=[(s=e-1,Math.floor(function(e){return Math.random()*e}(s)))],o=new Set;var s;for(let t=0;t<e;++t)r.includes(t)||o.add(t);for(;r.length<t;){const e=i(o.values(),(e=>Math.min.apply(Math,r.map((function(t,i){return n(e,t)})))));null!=e&&(r.push(e),o.delete(e))}return r}(i,Math.min(i,this.limit),((e,t)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(t)?0:n[r(e,t)]))}}var Pt,Rt,Ot=n(5433),kt=n(3890),Gt=n(1687);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(Pt||(Pt={}));class Ft{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const i=this.isWhitespace(n)?t:t-1;for(let e=0;e<i;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToAtomType(n),t[i]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){i=this.shiftIdxToXColumn(i);for(const o of[e,t,n])o[r]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const i=new Uint16Array(2);i[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),i[1]=this.parseIntValue(t),e[n]=i,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let i=0;i<e;i++)n=this.shiftIdxToBondType(n),t[i]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Dt extends Ft{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let i=0;i<t;i++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Bt extends Dt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(Pt.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,i]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,i)}}));const n=t.map(((e,t)=>{if(e.startsWith(Pt.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),i=n.map((e=>t[e])),r=n.map((e=>t[e+1]));i.forEach(((t,n)=>{const i=parseInt(t.split(/\s+/)[1])-1,o=parseInt(r[n].substring(1));if(e.has(o))throw new Error(`R group ${o} is already in the map`);e.set(o,i)}));const o=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==o.length)throw new Error(`Unaccounted R group indices: ${o}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(Pt.TYPE)&&-1!==e.indexOf(Pt.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,Pt.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<Pt.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,Pt.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,Pt.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+Pt.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=Pt.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Ht extends Dt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const i=t.match(/RGROUPS=\(([\d\s]+)\)/);if(i){const t=i[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Vt{constructor(){}static getInstance(e){if(Vt.isMolfileV2K(e))return new Bt(e);if(Vt.isMolfileV3K(e))return new Ht(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Bt.isValidMolfile(e)}static isMolfileV3K(e){return Ht.isValidMolfile(e)}}!function(e){e.BASE="HELM_BASE",e.SUGAR="HELM_SUGAR",e.LINKER="HELM_LINKER",e.AA="HELM_AA",e.CHEM="HELM_CHEM",e.BLOB="HELM_BLOB",e.NUCLEOTIDE="HELM_NUCLETIDE"}(Rt||(Rt={}));class jt{constructor(e){this.monomerLib=e}getCappedRotatedMonomer(e,t){const n=this.monomerLib.getMonomer(e,t);return n?n.molfile:null}}var Ut=n(5488),Wt={};Wt.styleTagTransform=A(),Wt.setAttributes=b(),Wt.insert=g().bind(null,"head"),Wt.domAPI=m(),Wt.insertStyleElement=w(),d()(Ut.A,Wt),Ut.A&&Ut.A.locals&&Ut.A.locals;class Yt{source;error;_monomers={};_onChanged=new u.Subject;_duplicateMonomers={};get duplicateMonomers(){return this._duplicateMonomers}_duplicatesHandled=!0;get duplicatesHandled(){return this._duplicatesHandled}duplicatesNotified=!1;constructor(e,t=void 0,n=void 0){this.source=t,this.error=n,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}toJSON(){const e=[];for(const t of Object.values(this._monomers))for(const n of Object.values(t))e.push({...n,lib:void 0,wem:void 0});return e}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let i=t;return t===fe.b9[me.Hi.HELM]?i="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(i="Any"),n[t]={symbol:t,name:i,molfile:"",author:"MISSING",id:-1,rgroups:ke().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let i=null;if(e){const t=this._monomers[e];i=t?t[n]:null}else{Di.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(i=t[n],i)break}return i}_monomerSets=null;getMonomerSet(e){const t=function(e){let t;switch(e){case Rt.BASE:case Rt.SUGAR:case Rt.LINKER:case Rt.NUCLEOTIDE:case"nucleotide":t="RNA";break;case Rt.AA:t="PEPTIDE";break;case Rt.CHEM:t="CHEM";break;case Rt.BLOB:t="BLOB";break;default:t="PEPTIDE",console.warn(`Unexpected HelmType '${e}'`)}return t}(e);if(this._monomerSets||(this._monomerSets={}),!(e in this._monomerSets))for(const[e,n]of Object.entries(this._monomers[t]));return this._monomerSets[e]}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let i=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return i=i.filter((e=>null!==e)),0===i.length?[]:(i=i.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;var i;return i=Vt.getInstance(t.molfile).atomTypes,i.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&=!0,n})),i.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateLibInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]&&(this._duplicateMonomers[t]??={},this._duplicateMonomers[t][n]??=[this._monomers[t][n]],this._duplicateMonomers[t][n].push(e.getMonomer(t,n))),this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateLibInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={}),this._duplicateMonomers={};for(const t of e)t.error||this._updateLibInt(t);Object.entries(this.duplicateMonomers).length>0?(0,$e.ub)().then((e=>{this.assignDuplicatePreferances(e)})):this._duplicatesHandled=!0,this._onChanged.next()}assignDuplicatePreferances(e){let t=!0;for(const n in this.duplicateMonomers)for(const i in this.duplicateMonomers[n])if(e.duplicateMonomerPreferences?.[n]?.[i]){const r=e.duplicateMonomerPreferences[n][i],o=this.duplicateMonomers[n][i].find((e=>e.lib?.source===r));o?this._monomers[n][i]=o:t=!1}else t=!1;return this._duplicatesHandled=t,t}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,i]of ke().enumerate(e))t[i]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=s.div([],{classes:"ui-form ui-tooltip"}),i=this.getMonomer(e,t);if(i){const e=i.symbol;i.name,n.append(s.divH([s.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),s.div([i.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let r;r=i.molfile?o.chem.svgMol(i.molfile,void 0,void 0,t):i.smiles?s.divV([o.chem.svgMol(i.smiles,void 0,void 0,t),s.divText("from smiles",{style:{fontSize:"smaller"}})]):s.divText("No structure",{style:{margin:"6px"}}),n.append(s.div(r,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(s.divText(i.lib?.source??"Missed in libraries"))}else n.append(s.divV([s.divText(`Monomer '${t}' of type '${e}' not found.`),s.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}class qt{monomerLib;symbol;polymerType;monomerType;monomerLinks;monomers;error=null;constructor(e,t,n,i,r){this.monomerLib=e,this.symbol=t,this.polymerType=n,this.monomerType=i,this.monomerLinks=r;try{this.monomers=this.monomerLinks.map((e=>{const n=this.monomerLib.getMonomer(this.polymerType,e.symbol);if(!n)throw new Error("Monomer not found: ");if(n.lib?.source!=e.source)throw new Error(`Monomer '${t}' found in different library.`);return n}))}catch(e){const[t,n]=(0,we.AP)(e);this.error=t,this.monomers=[]}}}class zt{description;placeholders;source;error;constructor(e,t,n=void 0,i=void 0){this.description=e,this.placeholders=t,this.source=n,this.error=i}updateSets(e,t=!1){t&&(this.placeholders=[]);for(const t of e)t.error||this._updateSetInt(t)}_updateSetInt(e){for(const t of e.placeholders)this.placeholders.push(t)}}var Kt=n(7433),Zt=n.n(Kt),Xt=n(1913),Jt=n.n(Xt);class Qt{helmMonomerSchema;validateMonomerSchema;constructor(e){this.helmMonomerSchema=e;const t=new(Zt())({allErrors:!0,strictTuples:!1,allowUnionTypes:!0});Jt()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;const i=new Set;for(const r of e){const e=r.symbol??r.id??r.name??"#N/A";if(n=this.validateMonomerSchema(r),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,r,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}const o=`${r.polymerType??""}-${e}`;i.has(o)&&console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' is duplicated.`,"Please, verify that the monomer library file does not contain duplicated monomer symbols."),i.add(o)}return n}}class en{fileValidator;libHelper;eventManager;logger;filesPromise=Promise.resolve();constructor(e,t,n,i){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.logger=i,this.eventManager.updateValidLibraryFileListRequested$.subscribe((()=>{this.updateValidLibList().then((()=>{}))})),this.eventManager.updateValidSetFileListRequested$.subscribe((()=>{this.updateValidSetList().then((()=>{}))}))}static objCounter=-1;objId=++en.objCounter;toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t,n){const i=await o.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),r=JSON.parse(i),s=new Qt(r);return new en(s,e,t,n)}async addLibraryFile(e,t,n=!0){try{if(await o.dapi.files.exists($e.so+`${t}`))return void o.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await o.dapi.files.writeAsText($e.so+`${t}`,e),await this.updateValidLibList(),await o.dapi.files.exists($e.so+`${t}`)?o.shell.info(`Added ${t} HELM library`):o.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),o.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await o.dapi.files.delete($e.so+`${e}`),await this.updateValidLibList(),o.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await o.dapi.files.exists($e.so+`${e}`)?o.shell.error(`Failed to delete ${e} library`):o.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const i=new a.FileSource(e),r=await i.readAsText(t);n=JSON.parse(r);const o={},s=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;s.includes(t)||(o[t]={},s.push(t)),o[t][n]=e})),new Yt(o,t)}async loadSetFromFile(e,t,n){let i={};const r=new a.FileSource(t),o=await r.readAsText(n);i=JSON.parse(o);const s=i.description,l=Object.entries(i.placeholders).map((([t,n])=>{const i=t,r=n.polymerType,o=n.monomerType,s=n.set;return new qt(e,i,r,o,s)}));return new zt(s,l)}getValidLibraryPaths(){return this.eventManager.getValidLibPathList()}getValidSetPaths(){return this.eventManager.getValidSetPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async updateValidLibList(){const e=`${this.toLog()}.updateValidLibList()`;return this.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{this.logger.debug(`${e}, IN`);const t=[],n=await this.getLibFileListAtLocation();if(!this.libListHasChanged(n))return void this.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await o.dapi.files.readAsText($e.so+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const i=n.filter((e=>!t.includes(e)));if(this.libListHasChanged(i)&&(this.eventManager.changeValidLibPathList(i),this.libHelper.loadMonomerLib(!0)),i.some((e=>!e.endsWith(".json")))&&this.logger.warning(`Wrong validation: ${i}`),t.length>0){const e=`Invalid monomer library files in ${$e.so}, consider fixing or removing them: ${t.join(", ")}`;this.logger.warning(e)}this.logger.debug(`${e}, OUT`)})),this.logger.debug(`${e}, end`),this.filesPromise}async updateValidSetList(){const e=`${this.toLog()}.updateValidSetList()`;return Di.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{Di.logger.debug(`${e}, IN`);const t=[],n=await this.getSetFileListAtLocation();if(!this.setListHasChanged(n))return void Di.logger.debug(`${e}, end, not changed`);for(const e of n)e.endsWith(".json")?await o.dapi.files.readAsText($e.Es+`${e}`):t.push(e);const i=n.filter((e=>!t.includes(e)));this.setListHasChanged(i)&&(this.eventManager.changeValidSetPathList(i),this.libHelper.loadMonomerSets(!0)),Di.logger.debug(`${e}, OUT`)})),Di.logger.debug(`${e}, end`),this.filesPromise}libListHasChanged(e){const t=this.eventManager.getValidLibPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}setListHasChanged(e){const t=this.eventManager.getValidSetPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getLibFileListAtLocation(){const e=`${this.toLog()}.getLibFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list($e.so).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring($e.so.length)))}async getSetFileListAtLocation(){const e=`${this.toLog()}.getSetFileListAtLocation()`;this.logger.debug(`${e}, start`);const t=await o.dapi.files.list($e.Es).then((e=>e.map((e=>e.fullPath)))),n=[];return n.push(...t),n.map((e=>e.substring($e.Es.length)))}}class tn{constructor(){}static _instance;static getInstance(){return tn._instance||(tn._instance=new tn),tn._instance}_libFilesUpdateSubject$=new u.BehaviorSubject([]);_setFilesUpdateSubject$=new u.BehaviorSubject([]);_addLibraryFilesSubject$=new u.Subject;_librarySelectionSubject$=new u.Subject;getValidLibPathList(){return this._libFilesUpdateSubject$.getValue()}getValidSetPathList(){return this._setFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{const t=this._libFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((n=>{e(n),t.unsubscribe()}))}))}changeValidLibPathList(e){this._libFilesUpdateSubject$.next(e)}changeValidSetPathList(e){this._setFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libFilesUpdateSubject$.pipe()}get updateValidSetFileListRequested$(){return this._setFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class nn{logger;_monomerLib=new Yt({},"MAIN");_monomerSets=new zt("MAIN",[]);_eventManager;get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,st.cb)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(e){this.logger=e}static objCounter=-1;objId=(()=>{if(++nn.objCounter>0)throw new Error("MonomerLibManager MUST be a singleton.");return nn.objCounter})();toLog(){return`MonomerLibManager<${this.objId}>`}getMonomerLib(){return this._monomerLib}getBioLib(){return this.getMonomerLib()}getMonomerSets(){return this._monomerSets}get duplicateMonomers(){return this._monomerLib.duplicateMonomers}get duplicatesHandled(){return this._monomerLib.duplicatesHandled}assignDuplicatePreferances(e){this._monomerLib.assignDuplicatePreferances(e)}_fileManagerPromise;async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await en.create(this,this._eventManager,this.logger))()),this._fileManagerPromise}loadLibrariesPromise=Promise.resolve();async loadMonomerLib(e=!1){const t=`${this.toLog()}.loadMonomerLib()`;return this.logger.debug(`${t}, start`),this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{this.logger.debug(`${t}, IN`);const n=a.TaskBarProgressIndicator.create("Loading monomers ...");try{const[[t],i]=await Promise.all([await this.getFileManager().then((e=>[e.getValidLibraryPaths()])),(0,$e.ub)()]),r=t.filter((e=>{const t=!i.exclude.includes(e),n=0===i.explicit.length||i.explicit.includes(e);return t&&n}));let o=0;const s=r.length,[a]=await Promise.all([Promise.all(r.map((e=>this.readLibrary($e.so,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Yt({},e,n)})).finally((()=>{n.update(Math.round(100*++o/s),`Loading monomers ${o}/${s}`)})))))]);this._monomerLib.updateLibs(a,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{n.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadLibrariesPromise}async loadLibraries(e){return this.loadMonomerLib(e)}loadSetsPromise=Promise.resolve();async loadMonomerSets(e=!1){const t=`${this.toLog()}.loadMonomerSets()`;return this.logger.debug(`${t}, start`),this.loadSetsPromise=this.loadSetsPromise.then((async()=>{this.logger.debug(`${t}, IN`);const e=a.TaskBarProgressIndicator.create("Loading monomer sets ...");try{const[[t]]=await Promise.all([await this.getFileManager().then((e=>[e.getValidSetPaths()]))]),n=t.filter((e=>!0));let i=0;const r=n.length,[o]=await Promise.all([Promise.all(n.map((t=>this.readSet($e.Es,t).catch((e=>{const n=`Loading monomer sets from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new zt("Broken monomer set",[],t,n)})).finally((()=>{e.update(Math.round(100*++i/r),`Loading monomers ${i}/${r}`)})))))]);this._monomerSets.updateSets(o)}catch(e){const t=`Loading monomer sets error: ${e instanceof Error?e.message:e.toString()}`;o.shell.warning(t);const n=e instanceof Error?e.stack:void 0;this.logger.error(t,void 0,n)}finally{e.close(),this.logger.debug(`${t}, OUT`)}})),this.logger.debug(`${t}, end`),this.loadSetsPromise}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async readSet(e,t){const n=await this.getFileManager();return await n.loadSetFromFile(this._monomerLib,e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,$e.ub)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,$e.Eu)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return null==e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new nn(Di.logger);return e._eventManager=tn.getInstance(),e})()),e}}var rn=n(1757),on=n.n(rn),sn=n(3017),an={};an.styleTagTransform=A(),an.setAttributes=b(),an.insert=g().bind(null,"head"),an.domAPI=m(),an.insertStyleElement=w(),d()(sn.A,an),sn.A&&sn.A.locals&&sn.A.locals;var ln=n(3151);class cn{constructor(e,t=[],n={}){this.onItemChanged=new u.Subject,this.onAddingItemChanged=new u.Subject,this.onItemAdded=new u.Subject,this.onItemRemoved=new u.Subject,this.options={removeButtonTooltip:"Remove item",addButtonTooltip:"Add item",allowAdd:!0,allowRemove:!0},this.properties=e,this.options=Object.assign(Object.assign({},this.options),n),this._root=s.divV([],{style:{display:"grid",gridTemplateColumns:`repeat(${this.properties.length}, 1fr)`,alignItems:"center",gap:"12px"},classes:"ui-items-grid"}),this._items=t,this.render()}get root(){return this._root}get items(){return this._items}set items(e){this._items=e,this.render()}addItem(e,t=!0){this._items.push(e),this.render(),t&&this.onItemAdded.next(e)}removeItem(e,t=!0){-1!==this._items.indexOf(e)&&(this._items.splice(this._items.indexOf(e),1),this.render(),t&&this.onItemRemoved.next(e))}removeAtIndex(e,t=!0){if(e<0||e>=this._items.length)return;const n=this._items.splice(e,1);this.render(),t&&this.onItemRemoved.next(n[0])}removeAllItems(){this._items=[],this.render()}render(){var e,t,n,i,r;if(s.empty(this._root),!this.options.horizontalInputNames)for(const n of this.properties){let i=null!==(e=n.caption)&&void 0!==e?e:n.name;(null===(t=this.options.customLabels)||void 0===t?void 0:t[n.name])&&(i=this.options.customLabels[n.name]);const r=s.divText(i);r.style.fontWeight="bold",this._root.appendChild(r)}for(const e of this._items){const t=this.getItemDiv(e);for(const e of t)this._root.appendChild(e)}if(this.options.allowAdd){const e=this.getItemDiv(null!==(r=null===(i=(n=this.options).newItemFunction)||void 0===i?void 0:i.call(n))&&void 0!==r?r:void 0,!0);for(const t of e)this._root.appendChild(t)}}getItemDiv(e={},t){var n,i;const r=[],o={};let l=null;for(const c of this.properties){void 0===e[c.name]&&(e[c.name]=null);const u=(null===(n=this.options.customInputs)||void 0===n?void 0:n[c.name])?this.options.customInputs[c.name](e):s.input.forProperty(c,e),h=null===(i=this.options.validators)||void 0===i?void 0:i[c.name];h&&u.addValidator(h),r.push(this.options.horizontalInputNames?u.root:this.hideLabel(u.root)),c.propertyType!==a.TYPE.BOOL&&"color"!==c.name.toLowerCase()&&u.input&&(u.input.style.width="100%"),o[c.name]=u,u.onChanged.subscribe((()=>{e[c.name]=u.value,t?this.onAddingItemChanged.next({item:e,fieldName:c.name}):this.onItemChanged.next({item:e,fieldName:c.name})})),u.root.style.alignItems="center",l=u}let c=null;if(t)c=s.icons.add((()=>{const e=this.options.newItemFunction?this.options.newItemFunction():{};Object.keys(o).forEach((t=>{e[t]=o[t].value})),this._items.push(e),this.onItemAdded.next(e),this.render()}),this.options.addButtonTooltip);else{if(!this.options.allowRemove)return r;c=s.icons.delete((()=>{this._items.splice(this._items.indexOf(e),1),this.onItemRemoved.next(e),this.render()}),this.options.removeButtonTooltip)}return l&&l.addOptions?l.addOptions(c):null==l||l.root.appendChild(c),c.style.color="#2083d5",r}hideLabel(e){return e.getElementsByTagName("label")[0]&&e.removeChild(e.getElementsByTagName("label")[0]),e}hasErrors(){return this._root.querySelectorAll(".d4-invalid").length>0}}const un={A:new V.A(new Uint32Array([2,0,0,0,16,0,0,0,134217728,0,0,0,32,0,33554432,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1048576,0,536870912,0,0,0,0]),2048),C:new V.A(new Uint32Array([2,0,65536,0,0,0,0,32,0,0,2,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,65536,0,0,524288,0,0,0,0,0,0,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536870912,64,0,0,0]),2048),D:new V.A(new Uint32Array([2,0,65600,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,2097152,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,512,0,0,34603008,0,536870912,0,0,0,0]),2048),E:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,16,134217728,0,0,0,0,0,0,524288,0,0,0,128,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,512,2147483648,0,34603008,0,536870912,0,0,0,0]),2048),F:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,262144,128,33554432,0,0,0,0,33554432,0,1024,1,0,524288,32768,32,0,0,0,0,16,524288,0,0,0,0,0,0,0,0,0,71303168,0,0,34603008,131072,536870912,0,0,0,0]),2048),G:new V.A(new Uint32Array([134217728,0,65536,0,0,0,0,0,0,0,0,0,32,0,0,0,0,0,0,0,1024,0,0,0,0,128,0,0,0,0,2097216,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,512,0,0,0,0,536870912,0,0,0,0]),2048),H:new V.A(new Uint32Array([2,0,1073840128,0,0,0,0,0,0,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,512,0,262144,192,0,268435456,0,0,8200,0,0,0,67108864,0,524296,0,32,0,0,0,0,16,524288,0,0,2147483648,0,0,8,0,0,0,0,0,0,34603008,131072,536870920,4194304,0,0,0]),2048),I:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,150994944,64,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,327680,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,256,0,0,0,0,8388608,0,33554432,0,1048576,0,536870912,0,0,0,0]),2048),K:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,0,0,0,0,268435488,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,2097152,0,0,67108864,0,0,524288,0,0,0,8,0,0,0,524288,0,0,8192,0,0,0,0,0,0,0,2147483648,0,34668544,0,545259520,0,0,0,0]),2048),L:new V.A(new Uint32Array([2,0,65536,0,0,0,0,0,134217728,0,0,0,32,512,0,0,0,0,0,0,1024,256,0,8388608,262400,128,0,0,0,0,0,0,0,2,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,42991616,0,536870912,0,0,0,0]),2048),M:new V.A(new Uint32Array([2050,0,65536,1048576,0,0,0,0,0,0,0,0,1056,0,0,0,0,0,0,0,1024,0,0,8,262144,128,0,0,0,0,0,536870912,0,2,0,0,1074266112,0,0,0,0,0,0,0,524288,0,0,0,4194304,0,0,0,0,0,0,2147483648,0,34603008,0,536870912,4194304,0,0,0]),2048),N:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,16777216,32,0,0,0,0,0,0,0,1024,0,0,0,262400,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,0,1024,0,0,0,524288,0,0,0,0,0,0,0,0,0,0,0,0,34603008,0,536871936,67108864,0,0,0]),2048),P:new V.A(new Uint32Array([0,0,1024,0,0,0,0,0,0,131072,0,1024,32,0,0,0,0,512,0,0,1024,0,0,64,0,128,0,0,1073741824,0,0,138412032,16,0,67108864,0,0,0,0,0,0,8192,0,0,8388608,0,0,8,0,0,0,0,0,0,256,0,0,0,0,553648128,0,0,0,0]),2048),Q:new V.A(new Uint32Array([2,0,65536,0,4096,0,0,0,0,0,0,0,32,0,0,0,0,2,0,0,1024,0,0,8,262144,128,0,0,16,0,0,0,0,0,0,0,524288,0,0,0,0,0,0,0,524288,0,0,0,268435456,0,0,0,0,0,16777216,2147483648,0,34603008,0,536871936,0,0,0,0]),2048),R:new V.A(new Uint32Array([2,0,65536,0,4096,0,32,0,0,0,0,0,268435488,0,0,0,0,0,0,32768,134218752,0,16,8,262144,128,0,1073741824,0,0,8388608,0,0,0,65536,0,524289,0,0,0,0,0,0,0,524288,2048,0,0,0,0,0,0,0,0,0,2147483648,0,34603008,1048576,545259520,0,0,0,0]),2048),S:new V.A(new Uint32Array([2,0,65536,0,0,0,1073741824,0,0,0,0,0,32,0,0,4,0,0,0,0,1024,0,0,0,262144,128,0,0,0,0,0,0,0,0,0,0,524288,0,0,1048576,0,0,0,0,524288,0,0,0,0,0,0,0,0,0,8388608,0,0,34603008,0,536870912,0,0,0,0]),2048),T:new V.A(new Uint32Array([2,0,0,0,0,0,0,8,134217728,0,0,67108864,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,0,0,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,536870912,0,0,0,0,1048576,67108864,536870912,0,0,0,0]),2048),V:new V.A(new Uint32Array([2,0,0,0,0,0,0,0,134217728,0,0,0,32,0,0,0,0,0,0,0,1024,0,8388608,0,262144,128,0,0,0,0,0,1073741824,128,2,0,524288,524288,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,8192,0,1048576,0,536870912,0,0,0,0]),2048),W:new V.A(new Uint32Array([2,0,98304,8388608,0,0,0,0,0,0,256,4096,32,0,0,0,0,0,0,0,1024,0,0,0,262144,192,0,0,0,0,0,0,0,0,67108865,0,524288,32768,32,0,0,0,8224,16,524288,0,0,0,0,32,128,0,2097152,0,4194304,8388608,0,34603008,8519680,536870912,131072,262144,0,0]),2048),Y:new V.A(new Uint32Array([2,0,98304,0,0,0,0,0,0,4194304,0,0,32,0,0,0,0,0,0,0,1024,0,0,512,262144,128,33554432,0,0,0,0,33554432,0,0,0,0,524288,0,32,0,0,2,0,16,524288,0,0,0,0,0,4,0,0,0,71303168,262144,0,34603008,131072,536870912,0,0,0,0]),2048)},hn={RNA:{A:new V.A(new Uint32Array([0,0,0,0,0,0,0,0,0,1024,0,67108864,0,0,0,512,0,0,0,8388608,0,0,512,0,0,64,4,0,0,0,4,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,659456,0,256,0,16,0,0,0,268435456,0,0,262144,0,131072,0,0,0,8388608,0]),2048),C:new V.A(new Uint32Array([0,1073741824,0,0,0,0,0,2147483648,4,67108864,0,67108864,0,256,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,0,67108864,0,524289,0,65536,0,0,0,0,16,0,131072,0,4,0,0,0,0,0,0,4194304,0,0,2147483648,131072,0,4096,0,0,0]),2048),G:new V.A(new Uint32Array([0,0,0,0,1024,0,0,0,0,67109888,16384,67108864,0,0,0,0,0,0,0,33562624,1024,33554432,512,16384,0,64,4,0,0,33554432,0,0,0,0,67108864,0,524289,0,0,0,0,0,0,16,0,135168,0,268435456,0,0,0,0,0,268435456,131072,0,0,2147483648,131072,0,0,0,8388608,0]),2048),T:new V.A(new Uint32Array([8388608,0,0,0,0,0,0,0,0,67108864,0,0,0,4,0,0,0,0,0,0,1024,0,0,16384,0,64,0,0,0,0,0,0,0,2,67108864,0,0,0,0,0,0,0,0,40976,0,0,0,0,0,0,0,0,0,67108864,131072,524288,0,0,8519680,0,1,33554432,1048576,0]),2048),U:new V.A(new Uint32Array([0,0,131072,1073741824,0,0,0,0,0,67108864,0,0,0,0,0,0,0,0,0,0,1024,0,128,0,0,64,0,0,0,0,0,0,0,32768,67108864,0,0,0,0,0,0,0,0,16,0,0,0,4,0,0,2048,0,0,0,4341760,0,0,0,131072,0,0,33554432,1048576,0]),2048)},PEPTIDE:un};async function dn(e,t,n=0){if(!Object.keys(hn).includes(t))return null;const i=await async function(e){const t=a.Func.find({package:"Chem",name:"getMorganFingerprint"})?.[0];if(!t)return null;try{const n=(await t.apply({molString:e}))?.getBuffer().buffer;if(n)return new V.A(new Uint32Array(n),2048)}catch(e){return null}}(e);if(!i)return null;const r=hn[t];let o=0,s=null;for(const[e,t]of Object.entries(r)){const r=(0,O.$1)(i,t);r>o&&r>=n&&(o=r,s=e)}return s}var pn,mn=n(857),fn={};fn.styleTagTransform=A(),fn.setAttributes=b(),fn.insert=g().bind(null,"head"),fn.domAPI=m(),fn.insertStyleElement=w(),d()(mn.A,fn),mn.A&&mn.A.locals&&mn.A.locals,function(e){e.MONOMER="Monomer",e.SYMBOL="Symbol",e.NAME="Name",e.R_GROUPS="~R-Groups",e.MONOMER_TYPE="Monomer Type",e.POLYMER_TYPE="Polymer Type",e.NATURAL_ANALOG="Natural Analog",e.AUTHOR="Author",e.CREATE_DATE="Create Date",e.ID="ID",e.META="Meta",e.SOURCE="Source"}(pn||(pn={}));const gn={[pn.MONOMER]:a.COLUMN_TYPE.STRING,[pn.SYMBOL]:a.COLUMN_TYPE.STRING,[pn.NAME]:a.COLUMN_TYPE.STRING,[pn.R_GROUPS]:a.COLUMN_TYPE.STRING,[pn.MONOMER_TYPE]:a.COLUMN_TYPE.STRING,[pn.POLYMER_TYPE]:a.COLUMN_TYPE.STRING,[pn.NATURAL_ANALOG]:a.COLUMN_TYPE.STRING,[pn.AUTHOR]:a.COLUMN_TYPE.STRING,[pn.CREATE_DATE]:a.COLUMN_TYPE.DATE_TIME,[pn.ID]:a.COLUMN_TYPE.INT,[pn.META]:a.COLUMN_TYPE.STRING,[pn.SOURCE]:a.COLUMN_TYPE.STRING};class yn{monomerLibManamger;static VIEW_NAME="Manage Monomers";_newMonomer=ln.pe;_newMonomerForm;monomerLib;tv=null;libInput;static instance;activeMonomerLib=null;constructor(e){this.monomerLibManamger=e,this.monomerLib=e.getBioLib(),this._newMonomerForm=new An(e,(()=>this.activeMonomerLib),(async()=>{const e=await this.getMonomersDf(this.libInput.value);this.tv?.dataFrame&&(this.tv.dataFrame=e)}),(()=>this.tv?.dataFrame))}static async getInstance(){if(!this.instance){const e=await nn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.instance=new yn(e)}return this.instance}async createNewMonomerLib(e,t){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{const n=JSON.stringify(t.map((e=>({...e,lib:void 0,wem:void 0}))));e.endsWith(".json")||(e+=".json"),await(await this.monomerLibManamger.getFileManager()).addLibraryFile(n,e),await o.dapi.files.writeAsText($e.so+e,n),await this.monomerLibManamger.loadLibraries(!1),o.shell.v=await this.getViewRoot(e)}catch(e){o.shell.error("Error creating library"),console.error(e)}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}async createNewLibDialog(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths(),n=s.input.string("Library Name",{placeholder:"Enter library name",nullable:!1,onValueChanged:()=>{const e=i(n.value);r.getButton("Create")?.classList?.toggle("d4-disabled",!!e)}});function i(e){return e&&e.trim()?e.endsWith(".json")&&t.includes(e)||t.includes(e+".json")?"Library with this name already exists":null:"Library name cannot be empty"}n.addValidator(i);const r=s.dialog("Create New Library").add(n).addButton("Create",(async()=>{const t=i(n.value);if(t)o.shell.warning(t);else{try{await this.createNewMonomerLib(function(){let e=n.value;return e.endsWith(".json")||(e+=".json"),e}(),e??[])}catch(e){o.shell.error("Error creating library"),console.error(e)}r.close()}})).show();r.getButton("Create")?.classList?.toggle("d4-disabled",!0)}get newMonomer(){return this._newMonomer}getNewMonomerForm(){return this._newMonomerForm}async getMonomersTableView(e){const t=await this.getMonomersDf(e);return this.tv=a.TableView.create(t,!0),this.tv.grid.col(pn.NAME).width=100,this.tv.subs.push(o.events.onContextMenu.subscribe((({args:e})=>{if(!e||!e.menu||!e.context||e.context.type!==a.VIEWER.GRID||!e.context.tableView||e.context.tableView.id!==(this.tv.id??"")||!e.item||!e.item.isTableCell||(e.item.tableRowIndex??-1)<0)return;const t=e.item.tableRowIndex;e.menu.item("Edit Monomer",(()=>{this.cloneMonomer(this.tv.dataFrame.rows.get(t))})),this.tv.dataFrame.selection.trueCount>0?(e.menu.item("Remove Selected Monomers",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>_n(this.tv.dataFrame.rows.get(e))));this._newMonomerForm.removeMonomers(e,this.libInput.value)})),e.menu.item("Selection To New Library",(()=>{const e=Array.from(this.tv.dataFrame.selection.getSelectedIndexes()).map((e=>_n(this.tv.dataFrame.rows.get(e))));this.createNewLibDialog(e)}))):e.menu.item("Remove Monomer",(()=>{const e=_n(this.tv.dataFrame.rows.get(t));this._newMonomerForm.removeMonomers([e],this.libInput.value)}))}))),this.tv}findActiveManagerView(){if(!this.tv)return null;const e=Array.from(o.shell.tableViews??[]).find((e=>e.id===this.tv.id));return e&&(o.shell.v=e),e??null}async getViewRoot(e){const t=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths();if(this._newMonomerForm.molSketcher.resize(),(this.tv=this.findActiveManagerView())&&(e??this.libInput.value)){this.libInput&&(this.libInput.items=t),e&&(this.libInput.value=e);const n=await this.getMonomersDf(e);return this.tv.dataFrame=n,this.tv.grid.col(pn.NAME).width=100,this.tv}e??=t[0],this.tv=await this.getMonomersTableView(e);let n=this.tv.getRibbonPanels();n.forEach(((e,t)=>{n[t]=e.filter((e=>0!==e.getElementsByClassName("grok-icon-filter").length))})),n=n.filter((e=>e.length>0));const i=s.icons.edit((()=>{(this.tv?.dataFrame?.currentRowIdx??-1)<0||this.cloneMonomer(this.tv.dataFrame.rows.get(this.tv.dataFrame.currentRowIdx))}),"Edit Monomer"),r=s.icons.delete((async()=>{const e=this.tv?.dataFrame?.currentRowIdx??-1,t=Array.from(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]);if(e<0&&0===t.length)return;if(t.length>0){const e=t.map((e=>_n(this.tv.dataFrame.rows.get(e))));return void await this._newMonomerForm.removeMonomers(e,this.libInput.value)}const n=_n(this.tv.dataFrame.rows.get(e));await this._newMonomerForm.removeMonomers([n],this.libInput.value)}));s.tooltip.bind(r,(()=>(this.tv?.dataFrame?.selection?.getSelectedIndexes()??[]).length>0?"Delete selected monomers":"Delete monomer"));const l=s.iconFA("arrow-to-bottom",(async()=>{const e=this.libInput.value;if(!e)return o.shell.error("No library selected");let t=null;try{t=await o.dapi.files.readAsText($e.so+e)}catch(t){return o.shell.error(`Error reading library ${e}`),console.error(t)}if(!t)return o.shell.error(`Library ${e} is empty`);a.Utils.download(e,t,"text/plain")}),"Download Monomer Library");n.push([i,r,l]),this.tv.setRibbonPanels(n),this.tv.name=yn.VIEW_NAME,this.libInput=s.input.choice("Monomer Library",{value:e,items:t,nullable:!1,onValueChanged:async()=>{try{const e=await this.getMonomersDf(this.libInput.value);this.tv.dataFrame=e}catch(e){console.error(e)}}}),this.libInput.addOptions(s.icons.add((()=>{this.createNewLibDialog()}),"Create new monomer library..."));const c=this._newMonomerForm.form;return c.prepend(this.libInput.root),this.tv.dockManager.dock(c,a.DOCK_TYPE.LEFT,null,void 0,.4),this.tv}cloneMonomer(e){return this._newMonomer=_n(e),this._newMonomerForm.setMonomer(this._newMonomer),this._newMonomer}async getMonomersDf(e){this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!0);try{if(e??=(await this.monomerLibManamger.getFileManager()).getValidLibraryPaths()[0],this.activeMonomerLib=await this.monomerLibManamger.readLibrary($e.so,e),!this.activeMonomerLib)return o.shell.error(`Library ${e} not found`),a.DataFrame.create();const t=this.activeMonomerLib.getPolymerTypes().flatMap((e=>this.activeMonomerLib.getMonomerSymbolsByType(e).map((t=>this.activeMonomerLib.getMonomer(e,t))))),n=a.DataFrame.create(t.length),i=new Set;for(const e of t)e.rgroups.forEach((e=>{e.label&&i.add(e.label)}));const r=Array.from(i);r.sort();for(const[e,t]of Object.entries(gn))if(n.columns.addNew(e,t),e===pn.R_GROUPS)for(const e of r)n.columns.addNew(e,a.COLUMN_TYPE.STRING);for(let e=0;e<t.length;e++){let i=xn(t[e].rgroups,t[e].smiles,t[e].molfile);i=bn(i),t[e].rgroups=Cn(t[e].rgroups);const o=r.map((n=>{const i=t[e].rgroups.find((e=>e.label===n));return i?wn(i,"capGroupSmiles"):""}));n.rows.setValues(e,[i,t[e].symbol,t[e].name,JSON.stringify(t[e].rgroups??[]),...o,t[e].monomerType,t[e].polymerType,t[e].naturalAnalog,t[e].author,t[e].createDate,t[e].id,JSON.stringify(t[e].meta??{}),t[e].lib?.source??""])}return n.col(pn.MONOMER).semType=a.SEMTYPE.MOLECULE,r.forEach((e=>{n.col(e).semType=a.SEMTYPE.MOLECULE})),n.currentRowIdx=-1,n.onCurrentRowChanged.subscribe((e=>{try{if(-1===n.currentRowIdx||this._newMonomerForm.molChanged)return;this.cloneMonomer(n.rows.get(n.currentRowIdx))}catch(e){console.error(e)}})),n}catch(e){throw o.shell.error("Error creating monomers dataframe"),console.error(e),e}finally{this.tv?.grid&&s.setUpdateIndicator(this.tv.grid.root,!1)}}}function bn(e){let t=e.replaceAll(/\[R[1-9]\]/g,(e=>`[*:${e[2]}]`));return t=t.replaceAll(/\[\d\*\]/g,(e=>`[*:${e[1]}]`)),t.replaceAll(/\[\d\*\:\d\]/g,(e=>`[*:${e[1]}]`))}const vn=["alternateId","capGroupName","capGroupSMILES","label"];function wn(e,t){const n=Object.keys(e).find((e=>e.toLowerCase()===t.toLowerCase()));if(n)return e[n]}function Cn(e){return e.map((e=>{const t=function(e,t){const n={};return e.forEach((e=>{const i=Object.keys(t).find((t=>t.toLowerCase()===e.toLowerCase()));i&&(n[e]=t[i])})),n}(vn,e),n=wn(t,"capGroupSMILES"),i=wn(t,"alternateId"),r=wn(t,"capGroupName"),o=wn(t,"label")??"R1";if(n&&i&&r||o.length<2)return t;if(i&&-1!==i.indexOf(`${o}-`)){const e=i.replace(`${o}-`,"");r||(t.capGroupName=e),n||(t.capGroupSMILES=`[*:${o.substring(1)}][${e}]`)}else r&&(n||(t.capGroupSMILES=`[*:${o.substring(1)}][${r}]`),i||(t.alternateId=`${o}-${r}`));return t}))}class An{monomerLibManager;getMonomerLib;refreshTable;getMonomersDataFrame;molSketcher;monomerTypeInput;polymerTypeInput;monomerSymbolInput;monomerNameInput;monomerIdInput;monomerNaturalAnalogInput;rgroupsGrid;metaGrid;saveButton;rgroupsGridRoot;_molChanged=!1;get molChanged(){return this._molChanged}saveValidationResult=null;triggerMolChange=!0;constructor(e,t,n,i){this.monomerLibManager=e,this.getMonomerLib=t,this.refreshTable=n,this.getMonomersDataFrame=i,this.molSketcher=new a.chem.Sketcher,this.molSketcher.root.classList.add("monomer-manager-sketcher"),this.polymerTypeInput=s.input.choice("Polymer Type",{value:"PEPTIDE",items:["PEPTIDE","RNA","CHEM","BLOB","G"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerTypeInput=s.input.choice("Monomer Type",{value:"Backbone",items:["Backbone","Branch","Terminal"],onValueChanged:()=>this.onMonomerInputChanged(),nullable:!1}),this.monomerSymbolInput=s.input.string("Monomer Symbol",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput=s.input.string("Monomer Name",{nullable:!1,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNameInput.nullable=!1,this.monomerIdInput=s.input.int("Monomer ID",{nullable:!0,value:0,onValueChanged:()=>this.onMonomerInputChanged()}),this.monomerNaturalAnalogInput=s.input.string("Natural Analog",{nullable:!0,onValueChanged:()=>this.onMonomerInputChanged()}),this.saveButton=s.bigButton("Save",(async()=>{const e=this.validateInputs();e?o.shell.warning(e):await this.saveMonomer()})),this.molSketcher.subs.push(this.molSketcher.onChanged.subscribe((async()=>{if(this.triggerMolChange){try{this.rgroupsGridRoot.style.display="none";let e=this.molSketcher.getSmiles();if(!e)return void(this.rgroupsGrid.items=[]);e=xn([],e);const t=this.findRgroupsInSmiles(e);if(0===t.length)return this.rgroupsGrid.items=[],void this.rgroupsGrid.render();const n=t.map((e=>Number.parseInt(e[0].match(/[1-9]/g)[0]))).map((e=>this.rgroupsGrid.items.find((t=>t.label===`R${e}`))??{capGroupSMILES:`[*:${e}][H]`,alternateId:`R${e}-H`,capGroupName:"H",label:`R${e}`}));this.rgroupsGrid.items.length!==n.length&&(this.rgroupsGrid.items=n),this.rgroupsGrid.render(),this.rgroupsGridRoot.style.display="flex";const i=await dn(En(e,n),this.polymerTypeInput.value??"");i&&(this.monomerNaturalAnalogInput.value=i)}catch(e){console.error(e)}this.onMonomerInputChanged(),this._molChanged=!0}else this.triggerMolChange=!0})));const r=[a.Property.js("capGroupSMILES",a.TYPE.STRING,{caption:"R-group SMILES",nullable:!1}),a.Property.js("alternateId",a.TYPE.STRING,{caption:"Alternate ID",nullable:!1}),a.Property.js("capGroupName",a.TYPE.STRING,{caption:"R-group name",nullable:!1}),a.Property.js("label",a.TYPE.STRING,{fieldName:"R-group Label",nullable:!1,userEditable:!1})];this.rgroupsGrid=new cn(r,[],{allowAdd:!1,allowRemove:!1,validators:{capGroupSMILES:e=>e?o.chem.checkSmiles(e)?null:"Invalid SMILES":"Cap group smiles is required",alternateId:e=>e?null:"Alternate ID is required",capGroupName:e=>e?null:"Cap group name is required",label:e=>e?null:"R-group label is required"},customLabels:{capGroupSMILES:"R-group SMILES",alternateId:"Alternate ID",capGroupName:"Cap Group Name",label:"Label"}}),this.rgroupsGrid.onItemChanged.subscribe((()=>this.onMonomerInputChanged())),this.rgroupsGridRoot=s.divV([this.rgroupsGrid.root]),this.rgroupsGridRoot.style.display="none";const l=[a.Property.js("Property",a.TYPE.STRING,{caption:"Property",nullable:!0}),a.Property.js("Value",a.TYPE.STRING,{caption:"Value",nullable:!0})];this.metaGrid=new cn(l,[]),this.onMonomerInputChanged()}onMonomerInputChanged(){setTimeout((()=>{this.saveValidationResult=this.validateInputs(),this.saveValidationResult?this.saveButton.classList.add("d4-disabled"):this.saveButton.classList.remove("d4-disabled");const e=this.polymerTypeInput.value&&this.polymerTypeInput.value&&!!this.getMonomerLib()?.getMonomer(this.polymerTypeInput.value,this.monomerSymbolInput.value);this.saveButton.textContent=e?"Save Monomer":"Add Monomer"}),200)}setMonomer(e){this.triggerMolChange=!1,this.molSketcher.setSmiles(e.smiles),this.polymerTypeInput.value=e.polymerType,this.monomerTypeInput.value=e.monomerType,this.monomerSymbolInput.value=e.symbol,this.monomerNameInput.value=e.name,this.monomerIdInput.value=e.id,this.monomerNaturalAnalogInput.value=e.naturalAnalog??null,this.rgroupsGrid.items=Cn(e.rgroups),this.metaGrid.items=Object.entries(e.meta??{}).map((([e,t])=>({Property:e,Value:t}))),this.rgroupsGrid.render(),this.metaGrid.render(),this.rgroupsGridRoot.style.display="flex",this.onMonomerInputChanged(),e.naturalAnalog||dn(En(e.smiles,this.rgroupsGrid.items),e.polymerType).then((e=>{e&&(this.monomerNaturalAnalogInput.value=e)}))}validateInputs(){if(!this.molSketcher.getSmiles())return"Monomer Molecule field is required";for(const e of[this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput])if(null==e.value||""===e.value)return`${e.caption} field is required`;if(this.rgroupsGrid.items.length<1)return"At least 1 R-group is required";for(const e of this.rgroupsGrid.items)for(const[t,n]of Object.entries(e))if(!n)return`R-group ${t} field is required for ${e.label}`;return this.rgroupsGrid.hasErrors()?"R-group fields contain errors":null}findRgroupsInSmiles(e){return[...Array.from(e.matchAll(/\[[1-9]\*\]/g)),...Array.from(e.matchAll(/\[\*\:[1-9]\]/g))]}get form(){const e=s.divV([this.polymerTypeInput,this.monomerTypeInput,this.monomerSymbolInput,this.monomerNameInput,this.monomerIdInput,this.monomerNaturalAnalogInput]),t=s.tabControl({Monomer:e,"R-groups":this.rgroupsGridRoot,Meta:s.divV([this.metaGrid.root])},!1);t.header.style.marginBottom="10px";const n=s.buttonsInput([this.saveButton]);return s.tooltip.bind(n,(()=>this.saveValidationResult??"Save monomer to library")),s.divV([this.molSketcher.root,t.root,n],{classes:"ui-form",style:{paddingLeft:"10px",overflow:"scroll"}})}get fieldInputs(){return{molecule:this.molSketcher,polymerType:this.polymerTypeInput,monomerType:this.monomerTypeInput,symbol:this.monomerSymbolInput,name:this.monomerNameInput,id:this.monomerIdInput,naturalAnalog:this.monomerNaturalAnalogInput}}get metaInputs(){return[]}get rgroupInputs(){return[]}getMonomerInfoTable(e){const t=xn(e.rgroups,e.smiles,e.molfile),n=o.chem.drawMolecule(t,150,150),i=s.tableFromMap({name:e.name,author:e.author,createDate:e.createDate});return s.divH([n,i],{style:{alignItems:"center"}})}async removeMonomers(e,t,n=!0){let i=[];try{const e=await o.dapi.files.readAsText($e.so+t);i=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const r=e.map((e=>Sn(i,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType))));for(let n=0;n<r.length;n++)if(-1===r[n])return void o.shell.error(`Monomer ${e[n].symbol} not found in library ${t}`);const a=r.map((e=>i[e])),l=s.divV(a.map((e=>this.getMonomerInfoTable(e))),{style:{maxHeight:"500px",overflow:"scroll"}}),c=a.length>1,u=c?`Are you sure you want to remove monomers ${a.map((e=>e.symbol)).join(", ")} from ${t} library?`:`Are you sure you want to remove monomer with symbol ${a[0].symbol} from ${t} library?`,h=s.dialog("Remove Monomer"+(c?"s":"")).add(s.h1(u)).add(l).addButton("Remove",(async()=>{i=i.filter((e=>!a.includes(e))),await o.dapi.files.writeAsText($e.so+t,JSON.stringify(i)),await(await nn.getInstance()).loadLibraries(!0),await this.refreshTable(),n&&o.shell.info(`Monomer${c?"s":""} ${a.map((e=>e.symbol)).join(", ")} ${c?"were":"was"} successfully removed from ${t} library`),h.close()})).show()}async addMonomerToLib(e,t){let n=[];try{const e=await o.dapi.files.readAsText($e.so+t);n=JSON.parse(e)}catch(e){return o.shell.error(`Error reading library ${t}`),console.error(e)}const i=Sn(n,(t=>t.symbol===e.symbol&&t.polymerType===e.polymerType)),r=this.getMonomersDataFrame()?.col(pn.MONOMER)?.toList()?.findIndex((t=>t===e.smiles)),a=async()=>{try{n=n.filter((t=>t.symbol!==e.symbol||t.polymerType!==e.polymerType)),n.push({...e,lib:void 0,wem:void 0}),await o.dapi.files.writeAsText($e.so+t,JSON.stringify(n)),await(await nn.getInstance()).loadLibraries(!0),await this.refreshTable(),o.shell.info(`Monomer ${e.symbol} was successfully saved in library ${t}`)}catch(e){o.shell.error("Error saving monomer"),console.error(e)}};let l=null,c="";if(i>=0)l=this.getMonomerInfoTable(n[i]),c=`Monomer with symbol '${e.symbol}' already exists in library ${t}.\nAre you sure you want to overwrite it?`;else if((r??-1)>=0){const e=_n(this.getMonomersDataFrame().rows.get(r));l=this.getMonomerInfoTable(e),c=`Monomer with the same structure already exists in library ${t} with different symbol (${e.symbol}).\nAre you sure you want to duplicate it?`}if(l){const e=s.dialog("Save Monomer").add(s.divText(c)).add(l).addButton("Save",(()=>{e.close(),a()})).show()}else await a()}async saveMonomer(){let e=this.molSketcher.getSmiles();if(!e||!o.chem.checkSmiles(e))return void o.shell.warning("Invalid SMILES");e=xn([],e);let t=o.chem.convert(e,a.chem.Notation.Smiles,a.chem.Notation.MolBlock);t=function(e){const t=e.split("\n"),n=t.findIndex((e=>e.startsWith("M")&&e.includes("ISO")));if(-1!==n){const e=t[n].indexOf("ISO");t[n]=t[n].substring(0,e)+"RGP"+t[n].substring(e+3)}const i=t.findIndex((e=>e.includes("V2000")||e.includes("V3000"))),r=Number.parseInt(t[i].trim().split(" ")[0]),o={};for(let e=i+1;e<i+1+r;e++){const n=t[e].indexOf("R ");if(-1===n)continue;"#"!==t[e][n+1]&&(t[e]=t[e].replace("R ","R#"));const r=t[e].trim().split(" ").map((e=>e.trim())).filter(Boolean);if(o[e-i]=1,r.length<14)continue;const s=Number.parseInt(r[13]);Number.isNaN(s)||(o[e-i]=s)}const s=Object.values(o);if(-1===t.findIndex((e=>e.startsWith("M")&&e.includes("RGP")))){const e=`M RGP ${s.length} ${Object.entries(o).map((([e,t])=>`${e} ${t}`)).join(" ")}`,n=t.findIndex((e=>e.startsWith("M")&&e.includes("END")));t.splice(n,0,e)}return t.join("\n")}(t);const n={};this.metaGrid.items.filter((e=>!!e.Property&&!!e.Value)).forEach((e=>{n[e.Property]=e.Value}));const i={symbol:this.monomerSymbolInput.value,name:this.monomerNameInput.value,molfile:t,smiles:e,polymerType:this.polymerTypeInput.value,monomerType:this.monomerTypeInput.value,naturalAnalog:this.monomerNaturalAnalogInput.value?this.monomerNaturalAnalogInput.value:void 0,id:this.monomerIdInput.value??0,rgroups:this.rgroupsGrid.items,author:a.User.current().friendlyName,createDate:(new Date).toISOString(),meta:n},r=this.getMonomerLib()?.source;r?await this.addMonomerToLib(i,r):o.shell.warning("Monomer library source is not specified")}}function Sn(e,t){let n=-1;for(let i=e.length-1;i>=0;i--)if(t(e[i])){n=i;break}return n}function xn(e,t,n){const i=!t||!o.chem.checkSmiles(t);if(i&&!n)throw new Error("Both SMILES and MOL block are empty or malformed");let r=i?o.chem.convert(n,a.chem.Notation.Unknown,a.chem.Notation.Smiles):t;return r=function(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=new RegExp(`\\[\\${e.capGroupName}:${t}\\]`,"g");n=n.replace(i,`[*:${t}]`)})),n=n.replaceAll(/\[\d[A-Z]{1,2}\]/g,(e=>`[*:${e[1]}]`)),n}(r,e),r=bn(r),i?r:o.chem.convert(r,a.chem.Notation.Unknown,a.chem.Notation.Smiles)}function En(e,t){let n=e;return t.forEach((e=>{const t=e.label[1]??"1",i=wn(e,"capGroupName");n=n.replace(`[*:${t}]`,`[${i}]`)})),n}function _n(e){const t=JSON.parse(e.get(pn.META)??"{}");for(const e in t)"object"==typeof t[e]&&(t[e]=JSON.stringify(t[e]));return{symbol:e.get(pn.SYMBOL),name:e.get(pn.NAME),molfile:"",smiles:e.get(pn.MONOMER),polymerType:e.get(pn.POLYMER_TYPE),monomerType:e.get(pn.MONOMER_TYPE),naturalAnalog:e.get(pn.NATURAL_ANALOG),id:e.get(pn.ID),rgroups:JSON.parse(e.get(pn.R_GROUPS)??"[]"),meta:t,author:e.get(pn.AUTHOR),createDate:e.get(pn.CREATE_DATE)}}class Mn{monomer;root=s.divV([],{classes:"monomer-card-root"});_selected=!1;get selected(){return this._selected}set selected(e){this._selected=e,this.root.style.border=e?"2px solid var(--green-2)":"2px solid var(--grey-2)"}constructor(e){this.monomer=e}render(){s.empty(this.root);const e=this.monomer.smiles&&o.chem.checkSmiles(this.monomer.smiles)?o.chem.drawMolecule(this.monomer.smiles,200,200):o.chem.drawMolecule(this.monomer.molfile??"",200,200);this.root.appendChild(e);const t=s.divH([s.divText("Monomer Name: "),s.divText(this.monomer.name)],{classes:"monomer-card-info-row"});if(this.root.appendChild(t),s.tooltip.bind(t,this.monomer.name),this.monomer.lib?.source){const e=s.divH([s.divText("Source: "),s.divText(this.monomer.lib.source)],{classes:"monomer-card-info-row"});this.root.appendChild(e),s.tooltip.bind(e,this.monomer.lib.source)}const n=s.divH([s.divText("Polymer Type: "),s.divText(this.monomer.polymerType)],{classes:"monomer-card-info-row"});this.root.appendChild(n),s.tooltip.bind(n,this.monomer.polymerType),s.tooltip.bind(this.root,"Select Monomer")}}class In{monomerSymbol;monomers;root=s.divH([],{style:{alignItems:"center",width:"100%",overflow:"hidden",visibility:"visible"},classes:"duplicate-monomer-symbol-row"});monomerCards;constructor(e,t,n,i){this.monomerSymbol=e,this.monomers=t,this.monomerCards=t.map((e=>new Mn(e)));const r=s.divH([],{style:{overflowX:"auto",width:"100%"}}),o=s.h1(e,{style:{lineHeight:"2em",fontSize:"1.5em",marginRight:"20px",width:"100px",overflow:"hidden",textOverflow:"elipsis"}});s.tooltip.bind(o,e),this.root.appendChild(o),this.root.appendChild(r),this.monomerCards.forEach((e=>{e.root.onclick=()=>{this.monomerCards.forEach((e=>e.selected=!1)),e.selected=!0,i(e.monomer)},n&&e.monomer===n&&(e.selected=!0),r.appendChild(e.root)}))}render(){this.monomerCards.forEach((e=>e.render()))}}class Tn{monomerCardRows=[];saveSettingsPromise=Promise.resolve();searchInput;_root;monomers;settings;filteredMonomerRows=[];static _instance;vv;static async getInstance(){return Tn._instance||(Tn._instance=new Tn,await Tn._instance.refresh(),(await nn.getInstance()).getMonomerLib().onChanged.subscribe((async()=>await Tn._instance.refresh()))),Tn._instance.refresh(),Tn._instance}async refresh(){this.settings=await(0,$e.ub)();const e=await nn.getInstance();await e.awaitLoaded(),await e.loadLibrariesPromise,this.monomers=e.duplicateMonomers,this.monomerCardRows=[];for(const t in this.monomers)for(const n in this.monomers[t]){const i=this.settings.duplicateMonomerPreferences?.[t]?.[n]??null,r=i?this.monomers[t][n].find((e=>e.lib?.source===i))??null:null;this.monomerCardRows.push(new In(n,this.monomers[t][n],r,(async i=>{this.saveSettingsPromise=this.saveSettingsPromise.then((async()=>{i.lib?.source&&(this.settings.duplicateMonomerPreferences=this.settings.duplicateMonomerPreferences??{},this.settings.duplicateMonomerPreferences[t]=this.settings.duplicateMonomerPreferences[t]??{},this.settings.duplicateMonomerPreferences[t][n]=i.lib.source,await(0,$e.Eu)(this.settings),o.shell.info(`Monomer '${i.name}' from source '${i.lib.source}' selected for symbol '${n}'.`),e.assignDuplicatePreferances(this.settings))}))})))}if(this.filteredMonomerRows=this.monomerCardRows,this.vv)this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)));else{this.vv=s.virtualView(this.monomerCardRows.length,(e=>(this.monomerCardRows[e].render(),this.monomerCardRows[e].root))),this.vv.root.classList.add("duplicate-monomers-virtual-view"),this.searchInput=s.input.string("Search",{placeholder:"Monomer Symbol",value:"",onValueChanged:()=>e(this.searchInput.value)}),this.searchInput.root.style.justifyContent="center",this.searchInput.input.style.width="200px",this._root=s.divV([s.h1("Manage Duplicate Monomer Symbols",{style:{textAlign:"center"}}),this.searchInput.root,s.divV([this.vv.root],{style:{overflowY:"auto",height:"100%"}})],{style:{height:"100%"}});const e=e=>{this.filteredMonomerRows=this.monomerCardRows.filter((t=>t.monomerSymbol.toLowerCase().includes(e.toLowerCase()))),this.vv.setData(this.filteredMonomerRows.length,(e=>(this.filteredMonomerRows[e].render(),this.filteredMonomerRows[e].root)))}}}constructor(){}get root(){return this._root}}async function Ln(){await Pn.showDialog()}class Nn{_fileManager;_widget;get widget(){return this._widget}constructor(){}static instancePromise;static async getInstance(){return void 0===Nn.instancePromise&&(Nn.instancePromise=(async()=>{const e=new Nn,t=await(0,ye.pj)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Nn.instancePromise}static async reloadWidget(){const e=await Nn.getInstance();e._widget=await e.createWidget()}async createWidget(){const e=await this.getWidgetContent();return(await(0,ye.pj)()).eventManager.addLibraryFileRequested$.subscribe((async()=>await this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await $n.createControlsForm();return on()(e).addClass("monomer-lib-controls-form"),s.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,i=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){o.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{i.close()}}})}}class $n{fileManager;userLibSettings;constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((async([e,t])=>{await this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){Di.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,ye.pj)().then((e=>e.getFileManager())),await(0,$e.ub)()]);return new $n(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=s.form(e);return on()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();on()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;Di.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),i=s.input.bool(e,{value:n,onValueChanged:()=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,i.value)}});s.tooltip.bind(i.root,`Include monomers from ${e}`);const r=s.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e))),a=s.icons.edit((async()=>{o.shell.v=await(await yn.getInstance()).getViewRoot(e)}),"Edit monomer library");return s.tooltip.bind(r,`Delete ${e}`),i.addOptions(a),i.addOptions(r),Di.logger.debug(`${t}, libFileName = '${e}', end`),i}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,$e.Eu)(this.userLibSettings);const n=await(0,ye.pj)();await n.loadMonomerLib(!0),o.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){s.dialog("Warning").add(s.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),o.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class Pn{constructor(){}static _instance;dialog;closeDialogSubject$=new u.Subject;static async showDialog(){Pn._instance||(Pn._instance=new Pn,Pn._instance.closeDialogSubject$.subscribe((()=>{Pn._instance.dialog=void 0}))),Pn._instance.dialog||(Pn._instance.dialog=await Pn._instance.getDialog()),Pn._instance.dialog.show()}async getDialog(){const e=tn.getInstance(),t=(await Nn.getInstance()).widget,n=s.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});return on()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t),n.onClose.subscribe((()=>this.closeDialogSubject$.next())),n}}class Rn{constructor(){}static _instance;_view;_duplicateManager;libManager;async getView(){const e=tn.getInstance(),t=(await Nn.getInstance()).widget,n=s.bigButton("Add",(()=>e.addLibraryFile()),"Upload new HELM monomer library"),i=s.bigButton("Merge",(()=>{this.mergeSelectedLibs()}),"Merge selected libraries into one"),r=s.splitH([s.divV([t.root,s.buttonsInput([n,i])],{classes:"ui-form"}),this._duplicateManager.root],{style:{width:"100%",height:"100%"}},!0);this._view=o.shell.newView("Manage Monomer Libraries",[r]),s.tools.waitForElementInDom(r).then((()=>{setTimeout((()=>{const e=Array.from(r.children).filter((e=>e.classList.contains("ui-box")));if(2!==e.length)return;const[t,n]=e,i=t.getBoundingClientRect().width+n.getBoundingClientRect().width,o=.3*i;t.style.width=`${o}px`;const s=i-o;n.style.width=`${s}px`}),100),this._view.subs.push(o.events.onCurrentViewChanged.subscribe((async()=>{try{const e=Rn._instance;e&&e._view&&"id"in o.shell.v&&o.shell.v.id===e._view.id&&e._duplicateManager?.refresh()}catch(e){console.error(e)}})))}))}static async showView(){if(Rn._instance||(Rn._instance=new Rn),Rn._instance._duplicateManager||(Rn._instance._duplicateManager=await Tn.getInstance()),Rn._instance.libManager||(Rn._instance.libManager=await nn.getInstance()),Rn._instance._view&&Array.from(o.shell.views).find((e=>e.id&&e.id===Rn._instance._view.id)))return o.shell.v=Rn._instance._view,void await Rn._instance._duplicateManager.refresh();Rn._instance.getView()}async mergeSelectedLibs(){const e="Library with this name already exists",t=await nn.getInstance();if(await t.awaitLoaded(),await t.loadLibrariesPromise,!t.duplicatesHandled)return void o.shell.warning("Selected libraries contain repeating symbols with different monomers.\n Please choose the correct monomer for each symbol using duplicate monomomer manager.");const n=t.getBioLib().toJSON(),i=s.dialog("Merge selected libraries"),r=s.input.string("Library Name",{placeholder:"Enter new library name",nullable:!1,onValueChanged:()=>{const t=u(r.value);i.getButton("Download")?.classList?.toggle("d4-disabled",!!t&&t!==e),i.getButton("Save")?.classList?.toggle("d4-disabled",!!t)}}),l=(await this.libManager.getFileManager()).getValidLibraryPaths();function c(){let e=r.value;return e.endsWith(".json")||(e+=".json"),e}function u(t){return t&&t.trim()?t.endsWith(".json")&&l.includes(t)||l.includes(t+".json")?e:null:"Library name cannot be empty"}r.addValidator(u),i.add(r).add(s.divText(`Total monomers: ${n.length}`)).addButton("Download",(()=>{a.Utils.download(c(),JSON.stringify(n))})).addButton("Save",(async()=>{i.close();const e=c(),t=JSON.stringify(n),r=await this.libManager.getFileManager();this._view&&s.setUpdateIndicator(this._view.root,!0);try{await r.addLibraryFile(t,e,!1);const n=await(0,$e.ub)();n.exclude=l,await(0,$e.Eu)(n),await this.libManager.loadLibraries(!0),await Nn.reloadWidget()}catch(t){o.shell.error(`Failed to save library ${e}. see console for details.`),console.error(t)}finally{this._view&&s.setUpdateIndicator(this._view.root,!1)}})).show(),i.getButton("Download")?.classList?.add("d4-disabled"),i.getButton("Save")?.classList?.add("d4-disabled")}}var On,kn=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};class Gn{constructor(e,t,n=!1,i){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._stopStartBtn=s.button(s.iconFA("pause"),(()=>kn(this,void 0,void 0,(function*(){return yield this._changeStopState()}))),"Play / pause"),this._restartBtn=s.button(s.iconFA("redo"),(()=>kn(this,void 0,void 0,(function*(){return yield this._restartScript()}))),"Restart"),this._nextStepBtn=s.button(s.iconFA("play"),(()=>kn(this,void 0,void 0,(function*(){this._isStepProcessed||(yield this._nextStep())}))),"Next step"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._closeBtn=s.button(s.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==i?void 0:i.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Gn.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=s.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(s.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=s.iconFA("clock");this._isAutomatic||0===t&&(n=s.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const i=s.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=s.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),o=s.divH([n,i],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var e,t,n;o.shell.windows.showContextPanel=!0,o.shell.windows.showHelp=!1;const i=o.shell.isInDemo?Array.from(o.shell.view("Browse").dockManager.rootNode.children)[0]:Array.from(o.shell.dockManager.rootNode.children)[0];this._node=o.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,i,""),(null===(t=null===(e=i.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=i.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return kn(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const l=n,c=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;try{yield this._steps[this._currentStep].func()}catch(e){o.shell.isInDemo=!1,console.error(e)}this._scrollTo(this._root,l.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,i,c),yield(0,st.cb)(c));const u=s.iconFA("check");if(i.replaceWith(u),u.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=s.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}if(o.shell.isInDemo){const e=o.shell.view("Browse");(null==e?void 0:e.preview)instanceof a.TableView&&(yield o.data.detectSemanticTypes(e.preview.dataFrame))}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return kn(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return kn(this,void 0,void 0,(function*(){const i=s.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const o=this._createSVGIndicator(r);i.append(o),e.prepend(i);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),i.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){return kn(this,void 0,void 0,(function*(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||(yield this._startScript()))}))}_restartScript(){return kn(this,void 0,void 0,(function*(){o.shell.dockManager.close(this._node),this._clearRoot(),this._setInitParams(),yield this.start()}))}_clearRoot(){this._root=s.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=s.panel([],"tutorials-main-header"),this._header=s.h2(""),this._headerDiv=s.divH([],"tutorials-root-header"),this._activity=s.panel([],"tutorials-root-description"),this._progressDiv=s.divV([],"tutorials-root-progress"),this._progress=s.element("progress"),this._progressSteps=s.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){o.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Gn.currentObject=null,o.shell.isInDemo=!1}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return kn(this,void 0,void 0,(function*(){this._initRoot(),o.shell.newView(this.name),this._isAutomatic?yield this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function Fn(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(t),Di.logger.error(e.message,void 0,n)}Gn.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(On||(On={}));const Dn="samples/FASTA_PT_activity.csv";async function Bn(){const e="Dendrogram",t=a.Func.find({package:e,name:"getTreeHelper"});if(0===t.length)throw new Error(`Package "${e}" must be installed for TreeHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}async function Hn(){return await o.functions.call("Dendrogram:getDendrogramService",{})}const Vn="samples/FASTA_PT_activity.csv",jn="sequence";const Un="samples/FASTA_PT_activity.csv";var Wn=n(5437);const Yn="samples/HELM.csv";var qn=n(966),zn=n(608),Kn=n(1619);class Zn{urlParams;funcName;options;df;view;constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=ke()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=o.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case ut.n5.fixWidth:case ut.n5.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Xn{tableInput;seqColInput;funcParamsDiv;get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=s.input.table("Table",{value:o.shell.tv.dataFrame,onValueChanged:()=>{this.onTableInputChanged()}});const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:e,filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.funcParamsDiv=s.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=s.input.column("Sequence",{table:this.tableInput.value,value:this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE)})}}var Jn=n(5785);const Qn=new class{tooltipHandlerTemp="tooltip-handler.Monomer"},ei={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class ti{gridCol;constructor(e){this.gridCol=e,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(e,t,n){if(e.grid.dart!=this.gridCol.grid.dart||e.gridColumn.dart!=this.gridCol.dart||!e.tableColumn||!e.isTableCell)return!1;const i=e.tableColumn.getTag(Tt.gp.alphabet),r=e.cell.value,a=e.grid.canvas.getBoundingClientRect(),l=e.bounds.right+a.left-4,c=e.bounds.bottom+a.top-4,u=zi();if(!u)return s.tooltip.show(s.divText("Monomer library is not available."),l,c),!0;const h=new jt(u),d=i===me.YI.DNA||i===me.YI.RNA?"RNA":(me.YI.PT,"PEPTIDE"),p=h.getCappedRotatedMonomer(d,r),m=s.div(r),f=p?o.chem.svgMol(p,void 0,void 0,ei):null;return s.tooltip.show(s.divV([m,...f?[f]:[]]),l,c),!0}static getOrCreate(e){let t=e.temp[Qn.tooltipHandlerTemp];return t||(t=e.temp[Qn.tooltipHandlerTemp]=new ti(e)),t}}class ni extends a.GridCellRenderer{get name(){return Ze.uF.MONOMER}get cellType(){return Ze.uF.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,i,r,o,s){if(o.gridRow<0)return;ti.getOrCreate(o.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,me.ny)(o.cell.column.getTag(Tt.gp.alphabet)),l=o.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c;const u=Math.max(2,Math.floor(.15*i));e.fillText((0,me.zS)(l,u),t+i/2,n+r/2,i)}}class ii{constructor(e,t,n=""){this.target=e,this.debugEnabled=t,this.prefix=n}error(e,t,n){return this.target.error(this.prefix+e,t,n)}warning(e,t){return this.target.warning(this.prefix+e,t)}info(e,t){return this.target.info(this.prefix+e,t)}debug(e,t){if(this.debugEnabled)return this.target.debug(this.prefix+e,t)}}class ri extends Map{_onPropertyChanged=new u.Subject;get onPropertyChanged(){return this._onPropertyChanged}get maxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set maxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get tooltipWebLogo(){return super.get("TooltipWebLogo")}set tooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get defaultSeparator(){return super.get("DefaultSeparator")}set defaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e))}}class oi extends a.Package{_properties;_rdKitModule;get rdKitModule(){return this._rdKitModule}get properties(){return this._properties}set properties(e){this._properties=e}_initialized=!1;get initialized(){return this._initialized}constructor(e={debug:!1}){super(),super._logger=new ii(super.logger,e.debug)}completeInit(e){this._rdKitModule=e,this._initialized=!0}handleErrorUI(e){const[t,n]=(0,we.AP)(e);o.shell.error(t),this.logger.error(t,void 0,n)}}var si=n(2174);class ai extends a.Widget{viewed=!1;seqCol;wlViewer=null;constructor(e){super(s.divV([])),this.seqCol=e}async init(){const e=fe.GO.forColumn(this.seqCol),t=Di.properties.tooltipWebLogo,n=this.seqCol.getTag(at.gp.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function li(e,t,n,i){const r=fe.GO.forColumn(e);let o=null,s=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(o=e),r.posList[e]==n&&(s=e);if(null===o&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===s&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<s)throw new Error(`End position ${s} exceeds positions length`);const a=i||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(o,s,a)}const ci={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(me.z1),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class ui{urlParams;funcName;view;data;constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??ci;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(me.gp.positionNames,this.data.positionNames),this.data.regions&&t.setTag(me.gp.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await o.data.detectSemanticTypes(this.data.df),this.view=o.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Di.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class hi{call;inputs=new class{table;sequence;region;start;end;name};constructor(e){this.call=e;const t=e=>this.call.inputParams[e].property.description;this.inputs.table=s.input.table("Table",{value:this.call.inputParams.table.value??o.shell.tv.dataFrame});const n=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE);this.inputs.sequence=s.input.column("Sequence",{table:o.shell.tv.dataFrame,value:n,onValueChanged:this.sequenceInputChanged.bind(this),filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE}),this.inputs.start=s.input.choice("Start",{onValueChanged:this.startInputChanged.bind(this)}),this.inputs.end=s.input.choice("End",{onValueChanged:this.endInputChanged.bind(this)}),this.inputs.region=s.input.choice("Region",{value:null,items:[],onValueChanged:this.regionInputChanged.bind(this)}),this.inputs.name=s.input.string("Column name",{value:this.getDefaultName(),onValueChanged:this.nameInputChanged.bind(this),clearIcon:!0}),this.inputs.name.onInput.subscribe((()=>this.nameInputInput.bind(this)));for(const e in this.call.inputParams)s.tooltip.bind(this.inputs[e].captionLabel,t(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&fe.GO.forColumn(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}fixRegion=!1;regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=fe.GO.forColumn(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?fe.GO.forColumn(e):null,n=this.inputs.start.input,i=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),i.options.add(r)}n.value=t?.posList[0]??"",i.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(me.gp.regions):null,n=t?JSON.parse(t):null,i=this.inputs.region.input;for(let e=i.options.length-1;e>=0;--e)i.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),i.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),i.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let i=e.options.length-1;i>=0;--i){const r=e.options[i],o=JSON.parse(r.value);o&&t===o.start&&n===o.end&&(e.selectedIndex=i)}}}defaultName=!0;defaultNameUpdating=!1;updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${i}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=s.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});s.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Di.handleErrorUI(e)}))})).show()}widget(){const e=s.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=s.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{Di.handleErrorUI(e)}))}));return a.Widget.fromRoot(s.divV([e,s.div(t)]))}}var di=n(8754);class pi{separator;separatorSplitter;splitter;constructor(e){this.separator=e,this.separatorSplitter=(0,Ge.dh)(this.separator),this.splitter=this._splitter.bind(this)}_splitter(e){const t=this.separatorSplitter(e);return new mi(t.originals,fe.b9[me.Hi.SEPARATOR])}async getHelm(e,t){const n="SequenceTranslator",i=a.Func.find({package:n,name:"polyToolConvert2"});if(0==i.length)throw new Error(`Package '${n}' must be installed for Cyclized notation provider.`);const r=i[0],o=await r.prepare({table:e.dataFrame,seqCol:e,...t}),s=a.Func.find({package:n,name:"getPolyToolConvertEditor"})[0];return(await s.prepare({call:o}).call()).getOutputParamValue()}}class mi extends Ge.Mu{seqCList;_canonicals=null;get canonicals(){if(!this._canonicals){const e=this.length;this._canonicals=new Array(e);for(let t=0;t<e;++t)this._canonicals[t]=this.getCanonical(t)}return this._canonicals}getCanonical(e){if(this.isGap(e))return be._S;let t=this.seqCList[e];if(null===t){const n=this.getOriginal(e);t=n,")"===n[n.length-1]&&(t=this.seqCList[e]=n.replace(/\(\d+\)$/,""))}return t}constructor(e,t){super(e,t),this.seqCList=new Array(this.length).fill(null)}}class fi extends pi{}var gi=n(8312),yi=n(9124);const bi=OCL;var vi=n(2582);class wi{monomerSymbol;constructor(e){this.monomerSymbol=e}atoms;bonds;rGroups;get atomCount(){return this.atoms.count}get bondCount(){return this.bonds.count}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,i=Math.atan(n);if(isNaN(i))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-i)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}var Ci=n(6956);class Ai{atoms;bonds;constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}rGroupIdToAtomicIndexMap;rGroupBondPositionMap=new Map;getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const i=n[0];return this.bonds.replacePositionsInBondsByDummy([i]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),i}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:i,nodeIdx:r}=n;this.bonds.bondedAtoms[i][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:i}=t;return this.bonds.bondedAtoms[n][(i+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const i=e[n-1];i===Ci.mP?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,i)}))}}class Si{coordinates=[];rawAtomLines=[];get count(){return this.coordinates.length}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,i=t.y+e.y;if(isNaN(n)||isNaN(i))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:i}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,i=t.y,r=n*Math.cos(e)-i*Math.sin(e),o=n*Math.sin(e)+i*Math.cos(e);if(isNaN(r)||isNaN(o))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:o}}))}}class xi extends Si{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Ei{bondedAtomPairs=[];rawBondLines=[];get count(){return this.bondedAtomPairs.length}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,i)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:i,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:i}=e;this.bondedAtomPairs[n][i]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class _i extends Ei{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Mi extends wi{constructor(e,t){super(t);const n=Vt.getInstance(e);this.atoms=new xi(n),this.bonds=new _i(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ii extends Si{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,i)=>{const r=this.coordinates[i],o=r.x.toFixed(4)+"00",s=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,i,r,a)=>t+o+i+s+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Ti extends Ei{molfileHandler;constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,i,r,o,s)=>`${n}${t[0]}${r}${t[1]}${s}`))}))}}class Li extends wi{constructor(e,t){super(t);const n=Vt.getInstance(e);this.atoms=new Ii(n),this.bonds=new Ti(n),this.rGroups=new Ai(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Ni{static getInstance(e,t){if(Vt.isMolfileV2K(e))return new Mi(e,t);if(Vt.isMolfileV3K(e))return new Li(e,t);throw new Error("Unsupported molfile version")}}class $i{monomerSymbol;monomerIdx;helm;monomerLib;molfileWrapper;capGroupElements=[];constructor(e,t,n,i,r,o){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=o;const s=this.getLibraryMonomerObject();let a=s.molfile;Vt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=Ni.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(s),n.bondedRGroupsMap.has(t)&&this.removeRGroups(n.bondedRGroupsMap.get(t)),this.capRemainingRGroups(),this.shiftCoordinates(i)}get atomCount(){return this.molfileWrapper.atomCount}get bondCount(){return this.molfileWrapper.bondCount}convertMolfileToV3KFormat(e,t,n){let i=null;try{if(i=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),i)return i.get_v3Kmolblock();throw new Error(`Cannot convert ${t} to molV3000`)}finally{i?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Pi{rdKitModule;monomerLib;constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.helm=new vi.f(e)}monomerWrappers=[];helm;addMonomer(e,t,n){const i=new $i(e,t,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(i)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),i=t.map((e=>this.monomerWrappers[e])),r=i[1].getAttachmentAtomByRGroupId(n[1]);i[0].replaceRGroupWithAttachmentAtom(n[0],r),i[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers();const i=new Array(this.monomerWrappers.length);for(const[n,r]of ke().enumerate(this.monomerWrappers)){const o=e.length,s=t.length;e.push(...n.getAtomLines()),t.push(...n.getBondLines()),i[r]={position:r,symbol:n.monomerSymbol,atoms:ke().count(o).take(n.atomCount).toArray(),bonds:ke().count(s).take(n.bondCount).toArray()}}const r=e.length,o=t.length;return{molfile:[this.getV3KHeader(r,o),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n"),monomers:i}}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const i=n+1;return e.replace(t,((e,t,n,r)=>t+i+r))})),"M V30 END BOND"].join("\n")}}class Ri{constructor(e){this.molfileHandler=Vt.getInstance(e)}molfileHandler;get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}var Oi=n(1054);class ki{helmColumn;df;libHelper;helmHelper;constructor(e,t,n,i){this.helmColumn=e,this.df=t,this.libHelper=n,this.helmHelper=i}convertToSmiles(e){const t=this.getSmilesList(e),n=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(n,t.map((e=>null===e?"":e)))}getSmilesList(e){return this.convertToMolfileV3KColumn(e).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),i=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){const t=bi.Molecule.fromMolfile(n[e]).toMolfileV3();i[e]=t.replace("STERAC1","STEABS");const o=e/n.length*100;r.update(o,`${o?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,i)}convertToRdKitBeautifiedMolfileColumn(e,t){const n=this.convertToMolfileV3KColumn(t).toList().map((e=>{if(""===e)return null;const n=t.get_mol(e);return n?(n.set_new_coords(),n.normalize_depiction(1),n.straighten_depiction(!0),n):null})),i=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return e?this.getMolV3000ViaOCL(n,i):a.Column.fromStrings(i,n.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}convertToMolfileV3KColumn(e){const t=this.getPolymerGraphColumn(),n=this.libHelper.getMonomerLib(),i=t.toList().map(((t,i)=>{const r=this.helmColumn.get(i);if(!r)return"";let o;try{o=this.getPolymerMolfile(r,t,e,n)}catch(e){const[t,n]=(0,we.AP)(e);Di.logger.error(t,void 0,n),o=Oi.v.empty()}return o.molfile})),r=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",r,i)}convertToMolfileV3K(e){const t=this.getPolymerGraphColumn(),n=this.libHelper.getMonomerLib(),i=t.toList().map(((t,i)=>{const r=this.helmColumn.get(i);if(!r)return{molfile:"",monomers:[]};let o;try{o=this.getPolymerMolfile(r,t,e,n)}catch(e){const[t,n]=(0,we.AP)(e);Di.logger.error(t,void 0,n),o=Oi.v.empty()}return o}));return i}getPolymerGraphColumn(){const e=this.helmColumn.toList(),t=this.helmHelper.getMolfiles(e);return a.Column.fromStrings("mols",t)}getPolymerMolfile(e,t,n,i){const r=new Ri(t),o=new Pi(e,n,i);return r.monomerSymbols.forEach(((e,t)=>{const n=r.getMonomerShifts(t);o.addMonomer(e,t,n)})),o.compileToMolfile()}}class Gi{libHelper;helmHelper;rdKitModule;constructor(e,t,n){this.libHelper=e,this.helmHelper=t,this.rdKitModule=n}getHelmToMolfileConverter(e,t){return new ki(t,e,this.libHelper,this.helmHelper)}async helmToAtomicLevel(e,t,n){const i=(e,t)=>e?e.columns.getUnusedName(t):t,r=e.dataFrame,o=i(r,`molfile(${e})`),s=i(r,`~${o}-hl`),l=this.getHelmToMolfileConverter(r,e),c=l.convertToMolfileV3K(this.rdKitModule),u=c.map((e=>{const t=e.molfile;if(""===t)return null;const n=this.rdKitModule.get_mol(t);return n?(n.set_new_coords(),n.normalize_depiction(1),n.straighten_depiction(!0),n):null}));let h;h=t?l.getMolV3000ViaOCL(u,o).toList():u.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t}));const d=c.map((e=>{const t=e.monomers,n={},i={};for(const[e,r]of ke().enumerate(t)){if(r>=2)continue;const t=[Math.random(),Math.random(),Math.random(),.3];for(const i of e.atoms)n[i]=t;for(const n of e.bonds)i[n]=t}return{atoms:Object.keys(n).map((e=>parseInt(e))),bonds:Object.keys(i).map((e=>parseInt(e))),highlightAtomColors:n,highlightBondColors:i}})),p=a.Column.fromStrings(o,h);p.semType="Molecule",p.temp[gi.P]=s;const m=a.Column.fromList(a.COLUMN_TYPE.OBJECT,s,d);return m.semType="Molecule-substruct",{molCol:p,molHighlightCol:m}}static getInstance(){let e=window.$seqHelperPromise;return null==e&&(e=window.$seqHelperPromise=(async()=>{if(!Di.initialized)throw new Error("Bio package is not initialized, call Bio:getSeqHelper");return new Gi(await nn.getInstance(),await(0,yi.b)(),Di.rdKitModule)})()),e}}async function Fi(e,t,n,i){const r=await async function(e,t,n,i){const r=(0,ve.R)(t),o=fe.GO.forColumn(t).getNewColumnFromList("ref",[n]),s=fe.GO.forColumn(o).getSplitted(0),l=i===pe.IDENTITY?function(e,t){const n=t.columns.length,i=new Array(n),r=new Array(n),o=new Array(n);for(let s=0;s<n;++s){const n=t.columns.byIndex(s);i[s]=n.getRawData(),r[s]=n.categories.indexOf("");const a=s<e.length?e.getOriginal(s):be._S;o[s]=n.categories.indexOf(a)}const s=a.Column.float("Identity",t.rowCount),l=s.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)(i[t]?i[t][n]:0)===o[t]&&++l[n];l[n]/=e.length}return s}(s,r):i===pe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,ye.uL)(n,e)}(s,r):null;if(null===l)throw new Error(`In bio library: Unknown sequence scoring method: ${i}`);return l.name=e.columns.getUnusedName(l.name),e.columns.add(l),l}(e,t,n,i);for(let e=0;e<r.length;e++)t.isNone(e)&&r.set(e,null,!1);return r}const Di=new oi;async function Bi(){return await nn.getInstance()}let Hi=null;class Vi{_palette;constructor(e){this._palette=e}get(e){return this._palette[e]}}let ji=null,Ui=null;async function Wi(){const e="Bio: _package.initBio()";let t,n;Di.logger.debug(`${e}, start`);const i=window.performance.now();await Promise.all([(async()=>{n=await nn.getInstance();const e=await(0,$e.ub)();e.explicit&&(e.explicit=[],await(0,$e.Eu)(e)),await Promise.all([n.loadMonomerLib(),n.loadMonomerSets()]),ji=n.getMonomerLib(),Ui=n.getMonomerSets()})(),(async()=>{const e=await Di.getProperties(),t=new ri(e);Di.properties=t})(),(async()=>{t=await(0,Pe.j)()})()]).finally((()=>{const t=window.performance.now();Di.logger.debug(`${e}, loading ET: ${t-i} ms`)})),Di.completeInit(t);const r=[],o=[],s=ji.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(s).forEach((e=>{r.push(e);const n=s[e].replaceAll("#R","O "),i=t.get_mol(n),a=JSON.parse(i.get_descriptors()).CrippenClogP;o.push(a),i?.delete()}));const a=o.reduce(((e,t)=>e+t),0)/o.length||0,l={};for(let e=0;e<r.length;e++)l[r[e]]=o[e]<a?"#4682B4":"#DC143C";Hi=new Vi(l),Di.logger.debug(`${e}, end`)}function Yi(e){const t=new ai(e);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();o.shell.error(t)})),t}function qi(){return ji}function zi(){return ji}function Ki(e){return fe.GO.forColumn(e)}function Zi(e){const t="getRegionTopMenu",n=a.Func.find({package:Di.name,name:t});if(1!==n.length)throw new Error(`Package '${Di.name}' func '${t}' not found`);const i=n[0].prepare({table:e.dataFrame,sequence:e});return new hi(i).widget()}async function Xi(e){return async function(){const e=s.label("Manage monomer libraries");return on()(e).addClass("d4-link-action"),e.onclick=async()=>await Ln(),new a.Widget(e)}()}function Ji(e){try{new hi(e).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;o.shell.error(`Get region editor error: ${t}`),Di.logger.error(t,void 0,n)}}function Qi(e){const t=new Xn;s.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function er(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function tr(e){const t=new Ae({semtype:a.SEMTYPE.MACROMOLECULE}),n=s.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()}));n.history((()=>({editorSettings:t.getStringInput()})),(e=>t.applyStringInput(e.editorSettings))),n.show()}function nr(){return new tt}function ir(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=Di.properties?Di.properties.maxMonomerLength:4;if(He.maxMonomerLength in e.tags){const t=parseInt(e.getTag(He.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const i=s.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:t=>{if(0==t)setTimeout((()=>{i.value=null}),0);else{const n=t??"",i=null==n?"":n.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=i,e.temp[".mm.cellRenderer.settingsChanged"]=Ke.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"}),r=s.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.temp[".mm.cellRenderer.settingsChanged"]=Ke.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),o=s.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),l=s.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),c=s.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),u=s.inputs([i,r,l,o,c]);return new a.Widget(u)}(e)}function rr(e){return(0,si.j)(e)}function or(){return new tt}function sr(){return new nt}function ar(e,t,n,i,r){const o=new gt.$(i,r,n,t);return"Local alignment"==e?o.smithWaterman():o.needlemanWunsch()}function lr(){return new ut.oP}function cr(){return new ft}function ur(e,t,n,i){return li(e,t??null,n??null,i??null)}async function hr(){const e=await yn.getInstance();await e.getViewRoot()}async function dr(e,t,n,i,r){const s=li(t,n??null,i??null,r??null);t.dataFrame.columns.add(s),await o.data.detectSemanticTypes(t.dataFrame)}async function pr(e,t,n,i,r,u,h,d,p){if(!(0,qn.V)(t,"Activity Cliffs"))return;const m=Te(e),f={units:t.meta.units,aligned:t.getTag(me.gp.aligned),separator:t.getTag(me.gp.separator),alphabet:t.getTag(me.gp.alphabet)},g=u,y=t,b=async()=>await de(e,y,m,"Activity cliffs",n,i,g,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,f,h,Ct,At,_t,void 0,p),v=r===c.c.UMAP?2e5:2e4,w=r===c.c.UMAP?5e3:2e3;if(e.rowCount>v)return void o.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${v}`);const C=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>w&&!d?.[l.vb]?s.dialog().add(s.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{b().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():b().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,we.AP)(e);throw Di.logger.error(t,void 0,n),e})).finally((()=>{C.close()}))}async function mr(e,t,n=1,i=.6,r="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:o,options:s}=await bt(e,t,r);return{entries:o,options:{...s,gapOpen:n,gapExtend:i}}}async function fr(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,wt.BQ)(e,!1);const n=e.temp["monomeric-mols"],i=await o.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(i.length).fill(null);for(let e=0;e<i.length;e++){if(i.isNone(e)||!i.get(e))continue;const t=i.get(e);r[e]=V.A.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}async function gr(e,t,i,r,c,u,h,d,p){const m=p?o.shell.view("Browse").preview:o.shell.tv.dataFrame==e?o.shell.tv:void 0;if((0,qn.V)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??={},await async function(e,t,i,r,c,u,h,d=!0,p=!1,m={preprocessingFuncArgs:[]},f={},g=null,y={}){const b={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==u.length||t.length!==c.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?f.tableView??o.shell.tableView(e.name)??o.shell.addTableView(e):null,w=async()=>{const w=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let C;try{const A=Te(e);function S(n,r,o){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!C&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??Le(t,i)}))),f[l.YP]&&(C?.root&&s.setUpdateIndicator(C.root,!1),c.init((e=>o[0]?o[0][e]:void 0)),u.init((e=>o[1]?o[1][e]:void 0)));const h=n/r*100;w.update(h,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function x(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??Le(t,i)}),s.setUpdateIndicator(C.root,!0));const p=o.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&C?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===C?.getOptions()?.look?.title&&(o.events.fireCustomEvent(U,{}),p.unsubscribe(),n?.(),w.close())})),g=new Promise((async(e,o)=>{try{n=e;const o=[];for(let e=0;e<u.length;++e){const n=u[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),n){const i=n.inputs[0].name,s=n.inputs[1].name,{entries:a,options:l}=await n.apply({[i]:t[e],[s]:r[e],...m.preprocessingFuncArgs[e]??{}});o.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const n=t[e].toList(),i={};o.push({entries:n,options:i}),m.distanceFnArgs.push(i)}}e(await z(o.map((e=>e.entries)),i,r,c,h,m,f[l.vb]?void 0:S))}catch(e){o(e)}})),y=await g;return w.close(),p.unsubscribe(),y}const E=await x();if(p&&E){const _=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const M=await function(e,t,i,r){return Ie(this,void 0,void 0,(function*(){return new Promise((function(o,s){const a=new Worker(new URL(n.p+n.u(682),n.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:i}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?s(e):o(t)}}))}))}(E[0],E[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init((e=>M[e].toString())),C&&(C.props.colorColumnName=I)}catch(T){o.shell.error("Clustering embeddings failed"),console.error(T)}finally{_.close()}}if(E){const L=e.columns.byName(A[0]),N=e.columns.byName(A[1]);if(L.init((e=>E[0][e])),N.init((e=>E[1][e])),g)try{const $=g.inputs[0].name,P=g.inputs[1].name;await g.prepare({[$]:L,[P]:N,...y}).call(!0)}catch(R){o.shell.error("Post-processing failed"),console.error(R)}if(C)return s.setUpdateIndicator(C.root,!1),C.helpUrl="/help/compute/sequence-space",C}}catch(O){o.shell.error("Dimensionality reduction failed"),console.error(O),w.close(),C&&s.setUpdateIndicator(C.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[l.vb])s.dialog().add(s.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await w();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await w();t(e)}}catch(e){n(e)}}))}(e,[t],i,[r],[1],[u],"MANHATTAN",c,d??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[l.vb],tableView:m})}async function yr(e,t,n){const i=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const i=(await Bi()).getMonomerLib();await(0,di.V)(e,t,n,i)}finally{i.close()}}function br(){(0,Kn.D)().catch((e=>{const[t,n]=(0,we.AP)(e);if(e instanceof zn.Ap)return o.shell.warning(e.element),void Di.logger.warning(t);o.shell.error(t),Di.logger.error(t,void 0,n)}))}async function vr(e=null,t=null){return(0,Kn.D)({col:e,clustersCol:t})}async function wr(){const e=o.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(fe.GO.forColumn(e),!0))),n=async t=>{if(!(0,qn.V)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});o.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let i=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),i=t.find((e=>fe.GO.forColumn(e).isMsa())),r=s.input.choice("Column",{value:i?i.name:e[0],items:e});s.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(s.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else i=t[0];i&&await n(i)}else o.shell.error("Current table does not contain sequences")}function Cr(e){return new ge.m(e).importFasta()}function Ar(e){return console.log(e),[]}function Sr(){const e=(0,Re.m)()[0];(0,Ot.C)(e)}function xr(){return new ni}async function Er(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await o.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let i=0;const r=[];for(const s of n)try{const t=await o.dapi.files.readAsText(e+s.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await o.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:s.path,result:"detected",column:e.name,message:`units: ${e.meta.units}`})}catch(e){r.push({file:s.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{i+=1,t.update(100*i/n.length,`Test ${s.fileName}`)}o.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const s=a.DataFrame.fromObjects(r);return s.name=`datasets_detectMacromolecule_${e}`,s}async function _r(e,t){await(0,Jn.k)(e,t)}function Mr(e){const t=fe.GO.forColumn(e).stats;return Object.keys(t.freq)}function Ir(){return new Nt}function Tr(){const e=o.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function Lr(){return new $t}function Nr(){const e=o.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function $r(e){const t=(0,Re.m)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new wt.a7(t)}function Pr(e){o.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),o.shell.tv.grid.scrollToCell(e,0)}async function Rr(e,t,n){return Fi(e,t,n,pe.IDENTITY)}async function Or(e,t,n){return Fi(e,t,n,pe.SIMILARITY)}async function kr(){Ln()}async function Gr(){await async function(){await Rn.showView()}()}function Fr(){(0,kt.TE)()}function Dr(){return new Gt._i}async function Br(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new Zn(e,"webLogoLargeApp"),n=await Di.files.readCsv("data/sample_PT_100000x5.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function Hr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new Zn(e,"webLogoAggApp"),n=await Di.files.readCsv("samples/FASTA_PT_activity.csv");await o.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function Vr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new ui(e,"getRegionApp");await t.init()}finally{e.close()}}async function jr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await Di.files.readCsv("samples/HELM_empty_vals.csv"),n=new ui(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function Ur(){const e=a.DataFrame.fromColumns((0,Ne.dW)());o.shell.addTableView(e)}function Wr(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(me.Hi.FASTA)]);o.shell.addTableView(e)}function Yr(){const e=a.DataFrame.fromColumns([(0,Ne.Hx)(me.Hi.HELM)]);o.shell.addTableView(e)}function qr(e,t){!function(e,t){const n=fe.GO.forColumn(e.column),i=Object.values(me.Hi).filter((e=>e!==n.units));t.group("Copy").items(i,(t=>{const n=e.column,i=e.rowIndex,r=fe.GO.forColumn(n),s=t===me.Hi.SEPARATOR?Di.properties.defaultSeparator:void 0,a=r.getJoiner({notation:t,separator:s})(r.getSplitted(i));navigator.clipboard?(navigator.clipboard.writeText(a),o.shell.info(`Value of notation '${t}' copied to clipboard`)):o.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t)}async function zr(){await async function(){let e,t;try{const n=new Gn("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity",!1,{autoStartFirstStep:!0});await n.step("Load DNA sequences",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,t=await Di.files.readCsv(Dn),e=o.shell.addTableView(t),e.grid.columns.byName("cluster").visible=!1,e.grid.columns.byName("sequence_id").visible=!1,e.grid.columns.byName("sequence").width=300,e.grid.columns.byName("activity").visible=!1,e.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const t=new Nt(!0);e.addViewer(t,{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"}),e.dockManager.dock(t,a.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await t.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});e.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{t.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{t.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Kr(){await async function(){let e,t,n,i,r;try{const s=new Gn("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results",!1,{autoStartFirstStep:!0});await s.step("Load DNA sequences",(async()=>{[i,e,t]=await Promise.all([Di.files.readCsv(Vn),Bn(),Hn()]),n=o.shell.addTableView(i),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(e,t,n){let i;{const e=Object.values(On);for(let n=0;n<e.length;n++){const i=e[n];if(!t.col(i)){const r=n==e.length-1;t.columns.add(a.Column.float(i,t.rowCount),r)}}if(t.rowCount>=1){const i=t.getCol(n).toList(),r=Date.now();Di.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const o=await z([i],"UMAP",[vt.xL.Levenshtein],[1],"MANHATTAN",{distanceFnArgs:[{}]}),s=Date.now();Di.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(s-r)/1e3} s`);for(let n=0;n<e.length;n++){const i=e[n],r=t.getCol(i),s=o[n];r.init((e=>s[e]))}const a=Date.now();Di.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-s)/1e3} s`)}i=await t.plot.fromType(a.VIEWER.SCATTER_PLOT,{xColumnName:On.X,yColumnName:On.Y,lassoTool:!0})}return e.dockManager.dock(i,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(n,i,jn),r.setOptions({color:"activity"})}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const r=await e.calcDistanceMatrix(i,[jn]),o=await xe(r.data,i.rowCount,1),s=e.parseClusterMatrix(o);t.injectTreeForGrid(n.grid,s,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.set(65,!0)}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{[67,72,77,82,83,84,85,91,93].forEach((e=>i.selection.set(e,!0))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Zr(){await async function(){let e,t,n,i,r;const s=c.c.UMAP;try{const l=new Gn("Activity Cliffs","Activity Cliffs analysis on Macromolecules data",!1,{autoStartFirstStep:!0});await l.step("Load DNA sequences",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,[n,e,t]=await Promise.all([Di.files.readCsv(Un),Bn(),Hn()]),i=o.shell.addTableView(n),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{const e=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];r=await pr(n,n.getCol("Sequence"),n.getCol("Activity"),80,s,yt.Z.LEVENSHTEIN,e,{},!0),i.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),on()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const r=a.TaskBarProgressIndicator.create("Running sequence clustering..."),o=await e.calcDistanceMatrix(n,["sequence"]),s=await xe(o.data,n.rowCount,1),l=e.parseClusterMatrix(s);r.close(),t.injectTreeForGrid(i.grid,l,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const e=r.dataFrame.temp[".cliffsDfGrid"];e.dataFrame.rowCount>0&&(e.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Xr(){await async function(){const e="HELM";let t,n,i;try{await new Gn("Atomic Level","Atomic level structure of Macromolecules",!1,{autoStartFirstStep:!0}).step("Loading Macromolecules notation 'Helm'",(async()=>{o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,t=await Di.files.readCsv("samples/HELM.csv"),n=o.shell.addTableView(t);for(let t=0;t<n.grid.columns.length;t++){const i=n.grid.columns.byIndex(t);[e,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=t.getCol(e);await yr(t,n,!1)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${e})`;t.currentCell=t.cell(1,n);const r=t.currentCell.value,o=new a.chem.Sketcher(a.chem.SKETCHER_MODE.INPLACE);o.setMolFile(r),i=s.dialog().add(o).show(),await(0,st.cb)(3e3),i.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Jr(){await async function(){let e,t,n,i,r,s;const l="msa(HELM)",h=c.c.UMAP,d=(await Wn.Nk.getDockerContainer()).id,p=Wn.Nk.getDockerContainer();let m,f;try{const c=new Gn("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data",!1,{autoStartFirstStep:!0});await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{[m,t]=await Promise.all([(async()=>(await p).status)(),Di.files.readCsv(Yn)]),e=o.shell.addTableView(t),o.shell.windows.showContextPanel=!1,o.shell.windows.showProperties=!1,"started"===m||"checking"===m?(Di.logger.debug(`demoBio05UI(), PepSeA ('${Wn.Nk.dcName}') docker container status = '${m}'.`),f=Promise.resolve()):(Di.logger.warning(`demoBio05UI(), PepSeA ('${Wn.Nk.dcName}') docker container is trying to start...`),await o.dapi.docker.dockerContainers.run(d),f=async function(e,t,n=3e4,i){const r=window.performance.now(),s=new u.Subject,a=async()=>{const n=await o.dapi.docker.dockerContainers.find(e);return n.status===t&&s.next(n),n};let l;try{await(0,st.PE)(s,(e=>{const n=window.performance.now();i.debug(`awaitStatus(), docker container ('${e.name}') GET status = '${t}' in ${n-r} ms.`)}),(async()=>{const e=await a();i.debug(`awaitStatus(), docker container ('${e.name}') HAS status = '${e.status}'.`),l=window.setInterval(a,200)}),n)}finally{window.clearInterval(l)}}(d,"started",3e4,Di.logger))}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{const e=a.TaskBarProgressIndicator.create("MSA by PepSeA ...");try{await f,n=t.getCol("HELM");const e=Wn.ZY[0],r=1.53,s=0;if(i=await(0,Wn.GD)(n,l,e,r,s,void 0),!i)throw new Error("Empty MSA result.");t.columns.add(i),await o.data.detectSemanticTypes(t)}finally{e.close()}}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{const n=a.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];s=await gr(t,i,h,yt.Z.LEVENSHTEIN,!0,n,void 0,void 0,!0),e.dockManager.dock(s,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await t.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(e){Fn(e)}}()}async function Qr(e){const t=(0,ye.uX)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}async function eo(e,t,n){const i=await e.readAsString();await async function(e,t,n){const i=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const s=await o.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await o.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${s.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,i.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,st.cb)(0))}l>0?o.shell.warning(`detectMacromolecule failed ${l} / ${n}`):o.shell.info(`detectMacromolecule success ${n}`)}finally{i.close()}}(i,t,n)}async function to(){return Gi.getInstance()}function no(e,t,n){return async function(e,t,n=!0){const i=(await Gi.getInstance()).getHelmToMolfileConverter(e,t).convertToRdKitBeautifiedMolfileColumn(n,Di.rdKitModule);return i.semType=a.SEMTYPE.MOLECULE,i}(e,t,n)}function io(e,t){e.temp[fe.j8.notationProvider]=new pi(t)}function ro(e,t){e.temp[fe.j8.notationProvider]=new fi(t)}},6625:(e,t,n)=>{"use strict";n.d(t,{$:()=>o});class i{value;parentI;parentJ;constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{seq1;seq2;score;constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class o{seq1="";seq2="";gap=1;len1=0;len2=0;step=1;alignGrid=[];scores=[];dpGrid=[];connections={};BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]];BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]];BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]];NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]];PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]];PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]];PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]];SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]];TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]];CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23};CONNUCL={A:0,T:1,C:2,G:3};CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63};fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",i="",o="";const s=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)o+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=o+n,i=this.seq2.substr((t-1)*this.step,this.step)+i):this.dpGrid[e][t].parentJ==t?(i=o+i,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:o+n,i=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+i:o+i);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,i,s)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunsch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new i);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let i=1;i<=this.len1;i++)for(let r=1;r<=this.len2;r++)this.fillOne(i,r),this.dpGrid[i][r].value<=0?(this.dpGrid[i][r].value=0,this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0):0==this.dpGrid[this.dpGrid[i][r].parentI][this.dpGrid[i][r].parentJ].value&&(this.dpGrid[i][r].parentI=0,this.dpGrid[i][r].parentJ=0),this.dpGrid[i][r].value>e&&(e=this.dpGrid[i][r].value,t=i,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,i=""){this.setMethod(i),this.setSequences(e,t),this.setGap(n)}}},8115:(e,t,n)=>{"use strict";n.d(t,{BQ:()=>m,a7:()=>h,if:()=>p,nI:()=>d});var i=n(4328),r=n(7389),o=n(6082),s=n(1407),a=n(4870),l=n(8070),c=n(2003);const u="substr_helm";class h{units;separator;inputsDiv;substructureInput;separatorInput;editHelmLink;columnsInput;grid;col;dialog;constructor(e){this.col=e[0],this.createUI()}editHelmLinkAction(){(0,a.K)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(u,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===c.Hi.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===c.Hi.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,a.K)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.meta.units,this.separator=this.col.getTag(c.gp.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=i.shell.tv.dataFrame;this.columnsInput=r.input.column("Column",{table:e,value:this.col,onValueChanged:e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()},filter:e=>e.semType===o.SEMTYPE.MACROMOLECULE}),this.substructureInput=r.input.string("Substructure",{value:""}),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const t=o.DataFrame.create(1);t.columns.addNewString(u).init((e=>"")),t.col(u).semType=this.col.semType,t.col(u).meta.units=c.Hi.HELM,this.grid=t.plot.grid(),this.separatorInput=r.input.string("Separator",{value:this.separator}),this.inputsDiv=r.div(),this.units=this.col.meta.units,this.separator=this.col.getTag(c.gp.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,n=this.units===c.Hi.HELM?t.get(u,0):this.substructureInput.value;this.units===c.Hi.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(n=n.replaceAll(this.separatorInput.value,this.separator)),e=this.units===c.Hi.HELM?await p(n,this.col):d(n,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const i=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=e.charAt(0)===t,r=e.charAt(e.length-1)===t,o=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return i?r?`${n}${o}${n}`:`${n}${o}${n}|${n}${o}$`:r?`^${o}${n}|${n}${o}${n}`:`^${o}${n}|${n}${o}${n}|${n}${o}$`}(e,n):e,r=o.BitSet.create(t.length);for(let n=0;n<t.length;n++){const o=t.get(n);(o.match(i)||o===e)&&r.set(n,!0,!1)}return r}async function p(e,t){t.version!==t.temp["last-invalidated-version"]&&await m(t,!0);const n=o.Column.string("helm",1).init((t=>e));n.semType=o.SEMTYPE.MACROMOLECULE,n.meta.units=c.Hi.HELM;const r=await(0,s.R)(n,!0,t.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:r.get(0),molBlockFailover:""})).get(0)}async function m(e,t){const n=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,l.cb)(10);const n=new Map,i=await(0,s.R)(e,t,n);e.temp["monomeric-mols"]=i,e.temp["monomers-dict"]=n,e.temp["last-invalidated-version"]=e.version}finally{n.close()}}},966:(e,t,n)=>{"use strict";n.d(t,{V:()=>s});var i=n(4328),r=n(6082),o=n(826);function s(e,t,n=[],s=[],a=!0){const[l,c]=function(e,t,n=[],s=[]){let a=!0,l="";const c=o.GO.forColumn(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)i.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==s.length?"any alphabet":`alphabet${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(e,t,n,s);return a&&!l&&i.shell.warning(c),l}},4139:(e,t,n)=>{"use strict";n.d(t,{HX:()=>u,J:()=>a,b9:()=>c,uF:()=>o});var i,r,o,s,a,l=n(5437);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(e){e.CELL_CHANGING="isCellChanging"}(s||(s={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:l.ZY[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},5433:(e,t,n)=>{"use strict";n.d(t,{C:()=>d});var i=n(6082),r=n(7389),o=n(4328),s=n(1757),a=n.n(s),l=n(2003),c=n(826);let u=null,h=[];function d(e){let t=e??o.shell.t.columns.bySemType("Macromolecule");if(!t)throw new Error("No column with Macromolecule semantic type found");let n=c.GO.forColumn(t),s=n.notation;const d=r.divText("Current notation: "+s,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),p=[l.Hi.FASTA,l.Hi.SEPARATOR,l.Hi.HELM],m=r.input.column("Column",{table:o.shell.t,value:t,onValueChanged:e=>{var o;(o=e).semType===i.SEMTYPE.MACROMOLECULE?(t=o,n=c.GO.forColumn(t),s=n.notation,s===l.Hi.HELM&&(y.value="/"),d.textContent="Current notation: "+s,g=p.filter((e=>e!==s)),v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b}),b(),u?.clear(),u?.add(r.div([d,m.root,v.root,y.root]))):m.value=t}}),f=["-",".","/"];let g=p.filter((e=>e!==s));const y=r.input.choice("Separator",{value:f[0],items:f}),b=()=>{v.value!==l.Hi.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.input.choice("Convert to",{value:g[0],items:g,onValueChanged:b});b(),v.onChanged.subscribe((()=>{b()})),null==u&&(u=r.dialog("Convert Sequence Notation").add(r.div([d,m.root,v.root,y.root])).onOK((async()=>{const e=v.value,n=e===l.Hi.SEPARATOR?y.value:void 0;await async function(e,t,n){const i=c.GO.forColumn(e).convert(t,n);e.dataFrame.columns.add(i);const r=await o.functions.call("Bio:detectMacromolecule",{col:i});return r&&(i.semType=r),await o.data.detectSemanticTypes(e.dataFrame),i}(t,e,n)})).show({x:350,y:100}),h.push(u.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],u=null}))))}},6740:(e,t,n)=>{"use strict";n.d(t,{m8:()=>s});var i=n(4328),r=n(8070),o=n(5437);async function s(e=6e4){const t=await o.Nk.getDockerContainer();await async function(e,t=6e4){let n=e,o=!1;for(let s=0;s<t/200;++s){if(null===n&&(n=await i.dapi.docker.dockerContainers.find(e.id)),a(n)){o=!0;break}switch(n.status){case"stopped":await i.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,r.cb)(200)}if(!o)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},6956:(e,t,n)=>{"use strict";n.d(t,{mP:()=>o,pk:()=>r,xe:()=>i});const i="|",r="$",o="H"},2582:(e,t,n)=>{"use strict";n.d(t,{f:()=>s});var i=n(6956);class r{constructor(e){const t=e.split(i.xe);t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}connectionItems;validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],i=t.split(",");i[2].split("-").forEach(((e,t)=>{const r=i[t],o=e.split(":"),s={monomerIdx:parseInt(o[0])-1,rGroupId:parseInt(o[1].slice(1))};n.push({polymerId:r,bond:s})})),e.push(n)})),e}}class o{simplePolymer;constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}polymerType;monomers;idx;monomerTypes;get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],i=[];return t.forEach((e=>{n.push(e),i.push("Backbone")})),{monomers:n,monomerTypes:i}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const i=t[n],r=t[n+1];e.push([{monomerIdx:i,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const i=n[t],r=i-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:i,rGroupId:1}])}return e}}class s{helmString;constructor(e){this.helmString=e;const t=this.helmString.split(i.pk),n=t[0].split(i.xe);this.simplePolymers=n.map((e=>new o(e))),""!==t[1]&&(this.connectionList=new r(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}bondData;simplePolymers;connectionList;bondedRGroupsMap;getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,i=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(i)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const i=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===i))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const i=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,i),t.push(...i)})),this.connectionList&&this.connectionList.getConnectionData().forEach((n=>{const i=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,i.push(r)})),t.push(i)})),t}}},1054:(e,t,n)=>{"use strict";n.d(t,{v:()=>i});class i{molfile;monomers;constructor(e,t){this.molfile=e,this.monomers=t}static empty(){return new i("",[])}}},1619:(e,t,n)=>{"use strict";n.d(t,{D:()=>T});var i=n(4328),r=n(6082),o=n(7389),s=n(8070),a=n(2003),l=n(826),c=n(608),u=n(5437),h=n(966),d=n(4139),p=n(6740),m=n(567),f=n(5072),g=n.n(f),y=n(7825),b=n.n(y),v=n(7659),w=n.n(v),C=n(5056),A=n.n(C),S=n(540),x=n.n(S),E=n(1113),_=n.n(E),M=n(6369),I={};async function T(e={}){return new Promise((async(t,n)=>{e.clustersCol??=null,e.pepsea??={},e.pepsea.method??=d.HX.pepsea.method,e.pepsea.gapOpen??=d.HX.pepsea.gapOpen,e.pepsea.gapExtend??=d.HX.pepsea.gapExtend;const a=e.col?.dataFrame??i.shell.t,l=e.col??a.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==l){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return i.shell.warning(e),void n(new c.Ap(o.divText(e)))}const h=o.input.choice("Method",{value:e.pepsea.method,items:u.ZY});h.setTooltip("Alignment method");const p=o.input.float("Terminal gap",{value:e?.kalign?.terminalGap});p.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const m=o.p(`Kalign version: ${d.b9}`,"kalign-version"),f=o.input.float("Gap open",{value:e.pepsea.gapOpen});f.setTooltip("Gap opening penalty at group-to-group alignment");const g=o.input.float("Gap extend",{value:e.pepsea.gapExtend});g.setTooltip("Gap extension penalty to skip the alignment");const y=o.inputs([f,g,p]),b=o.button("Alignment parameters",(()=>{y.hidden=!y.hidden,[f,g,p].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");b.classList.add("msa-params-button"),y.hidden=!0,b.prepend(o.icons.settings((()=>null)));const v=[h.root.style],w=[p.root.style,m.style];let C,A=l;const S=o.input.column("Sequence",{table:a,value:l,onValueChanged:async e=>{if(!e||e.semType!==r.SEMTYPE.MACROMOLECULE)return _.disabled=!0,await(0,s.cb)(0),void(S.value=A);A=e,_.disabled=!1,C=await N(S.value,a,v,w,h,x,f,g,p)},filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE});S.setTooltip("Sequences column to use for alignment");const x=o.input.column("Clusters",{table:a,value:e.clustersCol});x.nullable=!0;const E=o.dialog("MSA").add(S).add(x).add(h).add(y).add(b).add(m).onOK((async()=>{await L(S,a,C,t,n)})),_=E.getButton("OK");if(S.fireChanged(),e.col)return C=await N(e.col,a,v,w,h,x,f,g,p),void await L(S,a,C,t,n);E.show()}))}async function L(e,t,n,o,s){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return s("PepSeA container has not started");t.columns.add(a),await i.data.detectSemanticTypes(t),o(a)}catch(e){s(e)}finally{l.close()}}async function N(e,t,n,o,s,f,g,y,b){try{if(e.semType!==r.SEMTYPE.MACROMOLECULE)return;const i=t.columns.getUnusedName(`msa(${e.name})`);if((0,h.V)(e,e.name,[a.Hi.FASTA,a.Hi.SEPARATOR],[a.YI.DNA,a.YI.RNA,a.YI.PT],!1)){$(n,o,"kalign"),g.value=null,y.value=null,b.value=null;const t=l.GO.forColumn(e),r=t.isFasta()?e:t.convert(a.Hi.FASTA);return async()=>await(0,c.eE)(r,!1,i,f.value)}if((0,h.V)(e,e.name,[a.Hi.HELM],[],!1))return $(n,o,"pepsea"),g.value??=d.HX.pepsea.gapOpen,y.value??=d.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(e,i,s.value,g.value,y.value,f.value));if((0,h.V)(e,e.name,[a.Hi.SEPARATOR],[a.YI.UN],!1)){const t=l.GO.forColumn(e).convert(a.Hi.HELM);return $(n,o,"pepsea"),g.value??=d.HX.pepsea.gapOpen,y.value??=d.HX.pepsea.gapExtend,async()=>(await(0,p.m8)(),(0,u.GD)(t,i,s.value,g.value,y.value,f.value))}return g.value=null,y.value=null,b.value=null,void $(n,o,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();i.shell.error(t),m._package.logger.error(t)}}function $(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}I.styleTagTransform=_(),I.setAttributes=A(),I.insert=w().bind(null,"head"),I.domAPI=b(),I.insertStyleElement=x(),g()(M.A,I),M.A&&M.A.locals&&M.A.locals},608:(e,t,n)=>{"use strict";n.d(t,{Ap:()=>G,aZ:()=>H,eE:()=>D});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(3516),l=n(2003);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),p=e=>"object"==typeof e&&null!==e||"function"==typeof e,m=new Map([["proxy",{canHandle:e=>p(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>p(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(i){if(!i||!i.data)return;const{id:r,type:o,path:s}=Object.assign({path:[]},i.data),a=(i.data.argumentList||[]).map(x);let l;try{const t=s.slice(0,-1).reduce(((e,t)=>e[t]),e),n=s.reduce(((e,t)=>e[t]),e);switch(o){case"GET":l=n;break;case"SET":t[s.slice(-1)[0]]=x(i.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch((e=>({value:e,[d]:0}))).then((e=>{const[i,s]=S(e);t.postMessage(Object.assign(Object.assign({},i),{id:r}),s),"RELEASE"===o&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let i=!1;const r=new Proxy(n,{get(n,o){if(b(i),o===h)return()=>E(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),i=!0}));if("then"===o){if(0===t.length)return{then:()=>r};const n=E(e,{type:"GET",path:t.map((e=>e.toString()))}).then(x);return n.then.bind(n)}return v(e,[...t,o])},set(n,r,o){b(i);const[s,a]=S(o);return E(e,{type:"SET",path:[...t,r].map((e=>e.toString())),value:s},a).then(x)},apply(n,r,o){b(i);const s=t[t.length-1];if(s===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===s)return v(e,t.slice(0,-1));const[a,l]=C(o);return E(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},l).then(x)},construct(n,r){b(i);const[o,s]=C(r);return E(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:o},s).then(x)}});return r}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map((e=>e[0])),w(t.map((e=>e[1])))]}const A=new WeakMap;function S(e){for(const[t,n]of m)if(n.canHandle(e)){const[i,r]=n.serialize(e);return[{type:"HANDLER",name:t,value:i},r]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return m.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise((i=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==r||(e.removeEventListener("message",t),i(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:r},t),n)}))}const _="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),c=(s.data.argumentList||[]).map(m);let l;try{const u=n.slice(0,-1).reduce((d,p)=>d[p],e),f=n.reduce((d,p)=>d[p],e);switch(a){case"GET":l=f;break;case"SET":u[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(u,c);break;case"CONSTRUCT":{const d=new f(...c);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:p}=new MessageChannel;w(e,p),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(u){l={value:u,[y]:0}}Promise.resolve(l).catch(u=>({value:u,[y]:0})).then(u=>{const[f,d]=S(u);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),M(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function M(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function h(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(h(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(c=>c.toString())}).then(()=>{M(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const c=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return c.then.bind(c)}return b(e,[...r,n])},set(a,n,c){h(s);const[l,u]=S(c);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},u).then(m)},apply(a,n,c){h(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[u,f]=F(c);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:u},f).then(m)},construct(a,n){h(s);const[c,l]=F(n);return g(e,{type:"CONSTRUCT",path:r.map(u=>u.toString()),argumentList:c},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function F(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),k="eager",x="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const c=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${c}`),t.fs.symlink(c,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var c;let n=i;return((c=a==null?void 0:a.features)==null?void 0:c.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==x&&(s.loading=k,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};return t.config.printInterleaved&&(o=s.stdout),s.reinit===!0&&await this.reinit(s.tool),o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},async reinit(e){const r=t.tools.find(s=>s.tool==e),i=t.base.module.FS.cwd();Object.assign(r,r.config),r.ready=!1,await this.init(),r.isBaseModule&&this.mount(),this.cd(i)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=k),e.loading===x){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>{e.stdout+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{stdout:i}})},printErr:i=>{const s=t.config.printInterleaved?"stdout":"stderr";e[s]+=i+`
`,t.config.printStream&&postMessage({type:"biowasm",value:{[s]:i}})}});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",M=typeof window<"u"&&window.Blob&&new Blob([atob(_)],{type:"text/javascript;charset=utf-8"});function I(){const e=M&&(window.URL||window.webkitURL).createObjectURL(M);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+_)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const T={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,printStream:!1,callback:null,debug:!1,env:"prd"};class L{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},T,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new I;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(3629);class ${static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.vA)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}$.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class P{constructor(e="categorial"){this.aa2num=$.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const i=["NH2","COOH"];if(e.startsWith(i[0])){const n=i[0].length;(0,N.vA)("-"==e[n],`Wrong sequence format: ${i[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(i[1])){const t=i[1].length+1;(0,N.vA)("-"==e[n-t],`Wrong sequence format: ${i[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return P._dropDefises(P._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let i=0;i<t;++i){const t=e[i];(0,N.vA)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[i]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const i=e[n];(0,N.vA)(i in this.num2aa,`Unknown code '${i}' found in vector '${e}'`),t+=this.num2aa[i]}return t}}var R=n(4139);const O="input.fa",k="result.fasta";class G extends Error{element;constructor(e,t){super(e.innerText,t),this.element=e}}function F(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function D(e,t=!1,n="",i=null,o,s,c){let u=e.toList();t&&(u=u.map((e=>P.clean(e).replace(/\-/g,""))));const h=e.length;i??=r.Column.string("Clusters",h).init("0"),i.type!=r.COLUMN_TYPE.STRING&&(i=i.convertTo(r.TYPE.STRING)),i.compact();const d=i.categories,p=i.getRawData(),m=new Array(d.length),f=new Array(d.length);for(let e=0;e<h;++e){const t=p[e];(m[t]??=[]).push(u[e]),(f[t]??=[]).push(e)}H(f,d);const g=await new L(["base/1.0.0",{tool:"kalign",version:R.b9,reinit:!0}]),y=r.Column.string(n,h);for(let e=0;e<d.length;++e){const t=F(m[e]);await g.fs.writeFile(O,t);const n=`${void 0!==o?` --gpo ${o}`:""}${void 0!==s?` --gpe ${s}`:""}${void 0!==c?` --tgpe ${c}`:""}`,i=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(i);const r=await g.cat(k);if(!r){const e=B(i,1);throw new Error(e)}const l=new a.m(r).sequencesArray,u=f[e];for(let e=0;e<l.length;++e)y.set(u[e],l[e])}const b=e.meta.units,v=e.getTag(l.gp.alphabet);return y.meta.units=b,y.setTag(l.gp.aligned,"SEQ.MSA"),y.setTag(l.gp.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(e,t){const n=[],i=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=i.exec(e))&&(void 0===t||n.length<t);)n.push(r[1]);return n.join("\n")}function H(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=i.div([i.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...s()(n).take(3).map((e=>{let r=t[e];return r.length>25&&(r=r.slice(0,25)+"..."),i.divText(`"${r}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[i.divText("...")]:[]]);throw new G(e)}}},5437:(e,t,n)=>{"use strict";n.d(t,{Nk:()=>h,ZY:()=>d,GD:()=>m});var i=n(4328),r=n(6082),o=n(2003),s=function(e,t,n,i){return new(n||(n=Promise))((function(r,o){function s(e){try{l(i.next(e))}catch(e){o(e)}}function a(e){try{l(i.throw(e))}catch(e){o(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(s,a)}l((i=i.apply(e,t||[])).next())}))};function a(e){return s(this,void 0,void 0,(function*(){try{return yield e()}catch(e){throw console.error("Promise rejected"),new Error("Promise rejected")}}))}var l=n(608),c=n(4139),u=n(567);const h=new class{dcName="bio";async getDockerContainer(){return await i.dapi.docker.dockerContainers.filter(this.dcName).first()}},d=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],p=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function m(e,t,n="ginsi",i=1.53,s=0,u=null,d){const m=await h.getDockerContainer();if("started"!==m.status&&"checking"!==m.status)throw new Error("PepSeA container has not started yet");const g=e.length;u??=r.Column.int("Clusters",g).init(0),u.type!=r.COLUMN_TYPE.STRING&&(u=u.convertTo(r.TYPE.STRING));const y=u.categories,b=u.getRawData(),v=new Array(y.length),w=new Array(y.length);for(let t=0;t<g;++t){const n=b[t],i=y[n];if(""===i)continue;const r=y.indexOf(i),o=e.get(t);o&&((v[r]??=[]).push({ID:t.toString(),HELM:o}),(w[n]??=[]).push(t))}(0,l.aZ)(w,y);const C=new Array(g);for(const e of v){const t=(await a((()=>f(m.id,e,n,i,s,d)))).Alignment;for(const e of t)C[parseInt(e.ID)]=Object.entries(e).filter((e=>!p.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(c.J.SEPARATOR)}const A=r.Column.fromStrings(t,C);return A.meta.units=o.Hi.SEPARATOR,A.setTag(o.gp.separator,c.J.SEPARATOR),A.setTag(o.gp.aligned,"SEQ.MSA"),A.setTag(o.gp.alphabet,o.YI.UN),A.setTag(o.gp.alphabetIsMultichar,"true"),A.semType=r.SEMTYPE.MACROMOLECULE,A}async function f(e,t,n,r,o,s){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},l=`/align?method=${n}&gap_open=${r}&gap_extend=${o}`;let c;if("fetchProxy"in i.dapi.docker.dockerContainers){const t=window.performance.now(),n=await i.dapi.docker.dockerContainers.fetchProxy(e,l,a),r=window.performance.now();u._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${r-t} ms`);const o="application/json"===n.headers.get("content-type");if(!n.ok&&o){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const i=e["datagrok-error"];if(i)throw new Error(`Datagrok error: ${i}`);throw new Error(n.statusText)}if(!n.ok&&!o){const e=await n.text();throw new Error(`Error: ${e}`)}if(!o){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}c=await n.json()}else{const t=await i.dapi.docker.dockerContainers.request(e,l,a);if(!t)throw new Error("Empty response");c=JSON.parse(t);const n=c["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const r=c["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`)}if("pepsea-stderr"in c){const e=c["pepsea-stderr"];s?.warning(e)}return c}},3890:(e,t,n)=>{"use strict";n.d(t,{TE:()=>u});var i=n(6082),r=n(7389),o=n(4328),s=n(1991),a=n.n(s),l=n(826);const c=60;function u(){const e=o.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),s=n?[n.name]:[],u=r.input.multiChoice("Seq id columns",{value:s,items:t.map((e=>e.name))}),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const t=e.column;return!(!t||t.semType!==i.SEMTYPE.MACROMOLECULE)&&l.GO.forColumn(t).isFasta()})).toArray(),p=d.length>0?d[0].name:[],m=r.input.choice("Seq column",{value:p,items:d.map((e=>e.name))}),f=r.input.int("FASTA line width",{value:c});r.dialog({title:"Save as FASTA"}).add(r.inputs([u,m,f])).onOK((()=>{const t=u.value?u.value.map((t=>e.columns.byName(t).column)):[],n=m.value?e.columns.byName(m.value).column:null,i=f.value??c;n||o.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(e,t,n=c,i="\n"){const r=l.GO.forColumn(t),o=[];for(let s=0;s<t.length;s++){const t=e.map((e=>e.get(s).toString())).join("|"),a=h(r.getSplitted(s),n);o.push(`>${t}${i}`);for(const e of a)o.push(`${e}${i}`)}return"".concat(...o)}(t,n,i),s=document.createElement("a");s.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),s.setAttribute("download",`${e.dataFrame.name}.fasta`),s.click()})).show()}function h(e,t=c){let n=0;const i=e.length,r=[];for(;n<i;){const i=a()(e.originals).slice(n,n+t).toArray(),o=i.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");r.push(o),n+=i.length}return r}},8754:(e,t,n)=>{"use strict";n.d(t,{V:()=>u});var i=n(4328),r=n(7384),o=n(826),s=n(2003),a=n(6717),l=n(8312),c=n(966);async function u(e,t,n,u){let h;try{h=await(0,a.j)()}catch(e){return i.shell.warning('Transformation to atomic level requires package "Chem" installed.'),null}let d=null;if(n){const n=await(0,l.Q)(),i=o.GO.forColumn(t);let r,a,c;i.isHelm()?a=t:(c=t.name,t.name=`__${c}`,a=i.convert(s.Hi.HELM),a.name=c,e.columns.add(a,!1));try{r=await n.helmToAtomicLevel(a,!0,!0)}finally{a!==t&&(e.columns.remove(a.name),t.name=c)}e.columns.add(r.molCol),e.columns.add(r.molHighlightCol),d=r.molCol}else{if(!(0,c.V)(t,"To Atomic Level"))return null;const n=await(0,r.C4)(e,t,u);null!==n.col&&(e.columns.add(n.col,!0),d=n.col)}return d&&await i.data.detectSemanticTypes(e),d}},5785:(e,t,n)=>{"use strict";n.d(t,{k:()=>u});var i=n(4328),r=n(6082),o=n(8070),s=n(966),a=n(3077),l=n(4139),c=n(439);async function u(e,t){if(await(0,o.cb)(10),!(0,s.V)(t,"Sequence space"))return e;const n=(0,a.R)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=l.uF.MONOMER,e.setTag(c.gp.alphabet,t.getTag(c.gp.alphabet));const h=/(\d+)(?: \((\d+)\))?/,d=e=>{h.lastIndex=0;const t=e.match(h);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const i=n.columns.byIndex(e);i.semType=l.uF.MONOMER,i.setTag(c.gp.alphabet,t.getTag(c.gp.alphabet));const r=100;let o=0;for(;u.columns.byName(i.name)&&o<r;)i.name=d(i.name),o++;u.columns.add(i)}await i.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(r.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4870:(e,t,n)=>{"use strict";n.d(t,{K:()=>s,m:()=>o});var i=n(4328),r=n(6082);function o(){const e=i.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);if(null!==e)return e;i.shell.error("Current table does not contain macromolecules")}function s(e,t){e.innerHTML="",e.append(t)}},8047:(e,t,n)=>{"use strict";n.d(t,{n5:()=>v,oP:()=>M});var i=n(4328),r=n(7389),o=n(6082),s=n(1757),a=n.n(s),l=n(1991),c=n.n(l),u=n(1858),h=n(826),d=n(2003),p=n(4326);function m(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?m(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var f=n(2738),g=n(8070),y=n(7602);var b,v,w=n(2174),C=n(567);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new o.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},o.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class A{rowCount;value;plotValue;valueList=null;valueIdx=0;bounds;constructor(e=0,t){this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{pos;name;_label;get label(){return this._label?this._label:this.name}_freqs;sumRowCount=0;sumPlotValue;sumPlotValueForHeight;constructor(e,t,n,i){this.pos=e,this.name=t,this._freqs=n??{},i?.sumRowCount&&(this.sumRowCount=i.sumRowCount),i?.sumValueForHeight&&(this.sumPlotValue=i.sumValueForHeight),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?o.Column.fromFloat32Array(n,e):e instanceof Int32Array?o.Column.fromInt32Array(n,e):o.Column.fromList(o.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===p.fH.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const i=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-i*Math.log2(i)}}else if(e===p.fH.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,i,r,s,a,l,c){const u=i===p.fH.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let h=c*l+(n-u-1);const d=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f._S&&t[0]!==f._S?t[1].value-e[1].value:e[0]===f._S&&t[0]===f._S?0:e[0]===f._S?-1:1));for(const[n,i]of d){const n=u*i.plotValue/this.sumPlotValue;i.bounds=new o.Rect((e-t)*l*s,h,a*l,n),h+=n}}render(e,t,n,i,r){for(const[o,s]of Object.entries(this._freqs))if(o!==f._S){const a=(0,d.zS)(o,5),l=s.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=r.get(o)??r.get("other"),e.textAlign="left",e.font=t;const u=e.measureText(a);e.setTransform(l.width/u.width,0,0,l.height/i,c,l.top),e.fillText(a,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,i])=>i.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w.F)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(v||(v={}));const x=p.Fo;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const _=new class{render=20};class M extends o.JsViewer{static residuesSet="nucleotides";viewed=!1;seqHandler;initialized=!1;palette=null;host;msgHost;canvas;slider;textBaseline;seqCol=null;positions=[];visibleSlider=!1;allowResize=!0;turnOfResizeForOneSetValue=!1;sequenceColumnName;valueAggrType;valueColumnName;skipEmptySequences;skipEmptyPositions;positionWidth;_positionWidth;_positionWidthWithMargin;get positionWidthWithMargin(){return this._positionWidthWithMargin}minHeight;backgroundColor=4294967295;maxHeight;showPositionLabels;positionMarginState;positionMargin=0;_positionMargin;startPositionName;endPositionName;fixWidth;verticalAlignment;horizontalAlignment;fitArea;shrinkEmptyTail;positionHeight;filterSource;positionNames=[];positionLabels=void 0;startPosition=-1;endPosition=-1;error=null;get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===p.mH.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===p.mH.ON?this.positionMargin:0}constructor(){super(),this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA});const e=[o.AGG.KEY,o.AGG.PIVOT,o.AGG.MISSING_VALUE_COUNT,o.AGG.SKEW,o.AGG.KURT,o.AGG.SELECTED_ROWS_COUNT],t=Object.values(o.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(p.fH)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(p.Lp)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(p.P4)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(p.mH)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(p.lT)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.g(C._package.logger)}static viewerCounter=-1;viewerId=++M.viewerCounter;toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}viewSyncer;setDataInProgress=!1;viewSubs=[];async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest,_.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}lastSize={width:-1,height:-1};rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.mn)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=h.GO.forColumn(this.seqCol),this.palette=(0,d.SM)(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case p.lT.Filtered:e=this.dataFrame.filter;break;case p.lT.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=p.P4.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===p.Lp.TOP?"start":this.verticalAlignment===p.Lp.MIDDLE?"center":this.verticalAlignment===p.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const r=t>i;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,o=Math.max(1,Math.min(i,r));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const s=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*n,l=Math.min(this.root.clientWidth,s);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===p.Lp.TOP?"start":this.verticalAlignment===p.Lp.MIDDLE?"center":this.verticalAlignment===p.Lp.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=s>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}_onSizeChanged=new u.Subject;get onSizeChanged(){return this._onSizeChanged}_onFreqsCalculated=new u.Subject;get onFreqsCalculated(){return this._onFreqsCalculated}_onLayoutCalculated=new u.Subject;get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,i=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[i];if(!r)return[null,null,null];const o=r.getMonomerAt(n,e.y);return void 0===o?[r,null,null]:[r,o,r.getFreq(o)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f._S)||e.getFreq(f._S).rowCount!==e.sumRowCount)).toArray())}requestedRenderLevel=E.Freqs;renderRequest=new u.Subject;renderRequestSub;render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(d.gp.positionNames),t=this.seqCol.getTag(d.gp.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(d.z1).indexOf(this.endPositionName),n=-1!==n?n:void 0);const i=this.getFilter(),r=0===i.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return i.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(d.z1).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(d.z1).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const s=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=h.GO.forColumn(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<s;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}const l=this.dataFrame.rowCount;for(let e=0;e<s;++e){for(let t=0;t<l;++t)if(i.get(t)){const n=this.seqHandler.getSplitted(t),i=e<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===i?f._S:i,o=this.positions[e],s=o.getFreq(r);++o.sumRowCount,s.value=++s.rowCount}if(this.valueAggrType===o.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(let n=0;n<l;++n)if(i.get(n)){const i=this.seqHandler.getSplitted(n).getCanonical(this.startPosition+e),r=t.get(n);this.positions[e].getFreq(i).push(r)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===o.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<s;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),s=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const s=this.canvas.height-r*n;let a;if(this.valueAggrType===o.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==p.fH.Entropy&&null==e&&i.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let i=e;i<=t;++i)i in this.positions?this.positions[i].calcScreen(i,this.slider.min,s,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,s,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=o.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,i,r,o,s,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(s);t<=Math.floor(a);t++){const n=o[t],i=e.measureText(n.name),r=i.actualBoundingBoxDescent-i.actualBoundingBoxAscent;l=null===l?i.width:Math.max(l,i.width),c=null===c?r:Math.max(c,r)}const u=l<i*t-2?1:(i*t-2)/l;for(let l=Math.floor(s);l<=Math.floor(a);l++){const a=o[l],h=(l-s)*n*t+i*t/2,d=(r*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const i="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=s;e++)this.positions[e].render(a,i,l,c,this.palette)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}_lastWidth;_lastHeight;getAlphabetSize(){return this.seqHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===p.lT.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===p.lT.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const n=e,i=this.canvas.getCursorPosition(n,t),[s,a]=this.getMonomer(i,t),l=this.showPositionLabels?12*t:0;if(null!==s&&null===a&&0<=i.y&&i.y<=l){const e=[r.divText(`Position ${s.label}`)];this.valueAggrType===o.AGG.TOTAL_COUNT&&e.push(s.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==s&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=s.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==o.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const i=r.divV(t);r.tooltip.show(i,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[i,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==i&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,i,r,o){const s=t.getSplitted(i),a=o.pos<s.length?s.getCanonical(o.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,i)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),i=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+i)}catch(e){const t=m(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}_onRendered=new u.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.PE)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}},4577:(e,t,n)=>{"use strict";n.d(t,{O:()=>s,n:()=>o});var i=n(1858),r=n(567);class o{substructure;readOnly;constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class s{onChanged=new i.Subject;_props;_propsChanging=!1;get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},1687:(e,t,n)=>{"use strict";n.d(t,{_i:()=>E});var i=n(7389),r=n(6082),o=n(4328),s=n(1991),a=n.n(s),l=n(1858),c=n(2003),u=n(8070),h=n(826),d=n(7602),p=n(8115),m=n(4577),f=n(1757),g=n.n(f),y=n(9124),b=n(9192),v=n(4870),w=n(567);class C extends m.O{emptyProps=new m.n("");helmEditor;_filterPanel=i.div("",{style:{cursor:"pointer"}});logger;static viewerCounter=-1;viewerId=++C.viewerCounter;viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.logger=w._package.logger}viewSubs=[];async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await(0,y.b)();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await i.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=i.div(),n=e.createWebEditorApp(t,this.props.substructure),i.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new m.n(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(i.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,b.AP)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,b.AP)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),i.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,v.K)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=i.divText("Click to edit","helm-substructure-filter");(0,v.K)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;w._package.logger.debug(`${t}, start`);try{return await(0,u.cb)(10),await(0,p.if)(this.props.substructure,e)}finally{w._package.logger.debug(`${t}, end`)}}}const A="bio-substructure-filter";class S{props;filterId;dataFrameId;columnName;bitset;constructor(e,t,n,i,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=i,this.bitset=r}}class x extends m.n{separator;constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class E extends r.Filter{bioFilter=null;bitset=null;loader;notation=void 0;logger;filterSyncer;get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.root=i.divV([]),this.loader=i.loader(),this.calculating=!1,this.filterSyncer=new d.g(this.logger=w._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}static filterCounter=-1;filterId=++E.filterCounter;filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}viewSubs=[];attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),h.GO.forColumn(this.column),this.columnName??=this.column?.name,this.notation??=this.column?.meta.units,this.bioFilter=this.notation===c.Hi.FASTA?new _:this.notation===c.Hi.SEPARATOR?new M(this.column.getTag(c.gp.separator)):new C,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(o.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(o.events.onCustomEvent(A).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;w._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),o.events.fireCustomEvent(A,new S(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(w._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{w._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),w._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,w._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;w._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}_onRendered=new l.Subject;get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.cb)(10),await(0,u.PE)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const i=this.filterSyncer.resetErrors();if(i.length>0)throw i[0]}}class _ extends m.O{emptyProps=new m.n("");substructureInput;get type(){return"FastaBioFilter"}constructor(){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{window.setTimeout((()=>{this.props=new m.n(e),this._propsChanging||this.onChanged.next()}),0)},placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,p.nI)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class M extends m.O{emptyProps=new x("",void 0);substructureInput;separatorInput;colSeparator="";get type(){return"SeparatorBioFilter"}constructor(e){super(),this.substructureInput=i.input.string("",{value:"",onValueChanged:e=>{this.props=new x(e,this.props.separator),this._propsChanging||this.onChanged.next()},placeholder:"Substructure"}),this.separatorInput=i.input.string("",{value:this.colSeparator=e,onValueChanged:e=>{const t=e||void 0;this.props=new x(this.props.substructure,t),this._propsChanging||this.onChanged.next()},placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new x("")}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,p.nI)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},2174:(e,t,n)=>{"use strict";n.d(t,{F:()=>_,j:()=>E});var i=n(7389),r=n(6082),o=n(1991),s=n.n(o),a=n(2003),l=n(4152),c=n(5072),u=n.n(c),h=n(7825),d=n.n(h),p=n(7659),m=n.n(p),f=n(5056),g=n.n(f),y=n(540),b=n.n(y),v=n(1113),w=n.n(v),C=n(5999),A={};A.styleTagTransform=w(),A.setAttributes=g(),A.insert=m().bind(null,"head"),A.domAPI=d(),A.insertStyleElement=b(),u()(C.A,A),C.A&&C.A.locals&&C.A.locals;var S=n(826),x=n(2738);function E(e){const t=i.div();t.classList.add("macromolecule-cell-comp-analysis-host");const n=e.cell.column.tags[a.gp.alphabet];let o=l.oT.Color;switch(n){case a.YI.DNA:case a.YI.RNA:o=(0,a.ny)(a.YI.DNA);break;case a.YI.PT:o=(0,a.ny)(a.YI.PT)}const c={},u=S.GO.forColumn(e.cell.column),h=e.cell.rowIndex,d=u.getSplitted(h);s()(d.canonicals).filter((e=>e!==x._S)).forEach((e=>{const t=c[e]||0;c[e]=t+1}));const p=_(o,c);return Array.from(p.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),t.appendChild(p),new r.Widget(t)}function _(e,t){let n=0,o=null;for(const e of Object.values(t))n+=e,o=null===o?e:Math.max(o,e);const s=o/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,o])=>{const a=o/n,l=e.get(t),c=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});c.style.width=50*a/s+"px",c.style.backgroundColor=l,x._S===t&&(c.style.borderWidth="1px",c.style.borderStyle="solid",c.style.borderColor=r.Color.toHtml(r.Color.lightGray));const u=x._S===t?"-":t,h=i.div(`${(100*a).toFixed(2)}%`),d=i.div([c,h],{classes:"macromolecule-cell-comp-analysis-value"});return{[u]:d}}))),l=i.tableFromMap(a);return Array.from(l.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),l}},1757:e=>{"use strict";e.exports=$},6082:e=>{"use strict";e.exports=DG},4328:e=>{"use strict";e.exports=grok},1858:e=>{"use strict";e.exports=rxjs},7389:e=>{"use strict";e.exports=ui},1991:e=>{"use strict";e.exports=wu},8343:(e,t,n)=>{"use strict";const{normalizeIPv6:i,normalizeIPv4:r,removeDotSegments:o,recomposeAuthority:s,normalizeComponentEncoding:a}=n(4834),l=n(343);function c(e,t,n,i){const r={};return i||(e=p(u(e,n),n),t=p(u(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(r.scheme=t.scheme,r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(r.userinfo=t.userinfo,r.host=t.host,r.port=t.port,r.path=o(t.path||""),r.query=t.query):(t.path?("/"===t.path.charAt(0)?r.path=o(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?r.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:r.path=t.path:r.path="/"+t.path,r.path=o(r.path)),r.query=t.query):(r.path=e.path,void 0!==t.query?r.query=t.query:r.query=e.query),r.userinfo=e.userinfo,r.host=e.host,r.port=e.port),r.scheme=e.scheme),r.fragment=t.fragment,r}function u(e,t){const n={host:e.host,scheme:e.scheme,userinfo:e.userinfo,port:e.port,path:e.path,query:e.query,nid:e.nid,nss:e.nss,uuid:e.uuid,fragment:e.fragment,reference:e.reference,resourceName:e.resourceName,secure:e.secure,error:""},i=Object.assign({},t),r=[],a=l[(i.scheme||n.scheme||"").toLowerCase()];a&&a.serialize&&a.serialize(n,i),void 0!==n.path&&(i.skipEscape?n.path=unescape(n.path):(n.path=escape(n.path),void 0!==n.scheme&&(n.path=n.path.split("%3A").join(":")))),"suffix"!==i.reference&&n.scheme&&(r.push(n.scheme),r.push(":"));const c=s(n,i);if(void 0!==c&&("suffix"!==i.reference&&r.push("//"),r.push(c),n.path&&"/"!==n.path.charAt(0)&&r.push("/")),void 0!==n.path){let e=n.path;i.absolutePath||a&&a.absolutePath||(e=o(e)),void 0===c&&(e=e.replace(/^\/\//u,"/%2F")),r.push(e)}return void 0!==n.query&&(r.push("?"),r.push(n.query)),void 0!==n.fragment&&(r.push("#"),r.push(n.fragment)),r.join("")}const h=Array.from({length:127},((e,t)=>/[^!"$&'()*+,\-.;=_`a-z{}~]/u.test(String.fromCharCode(t)))),d=/^(?:([^#/:?]+):)?(?:\/\/((?:([^#/?@]*)@)?(\[[^#/?\]]+\]|[^#/:?]*)(?::(\d*))?))?([^#?]*)(?:\?([^#]*))?(?:#((?:.|[\n\r])*))?/u;function p(e,t){const n=Object.assign({},t),o={scheme:void 0,userinfo:void 0,host:"",port:void 0,path:"",query:void 0,fragment:void 0},s=-1!==e.indexOf("%");let a=!1;"suffix"===n.reference&&(e=(n.scheme?n.scheme+":":"")+"//"+e);const c=e.match(d);if(c){if(o.scheme=c[1],o.userinfo=c[3],o.host=c[4],o.port=parseInt(c[5],10),o.path=c[6]||"",o.query=c[7],o.fragment=c[8],isNaN(o.port)&&(o.port=c[5]),o.host){const e=r(o.host);if(!1===e.isIPV4){const t=i(e.host,{isIPV4:!1});o.host=t.host.toLowerCase(),a=t.isIPV6}else o.host=e.host,a=!0}void 0!==o.scheme||void 0!==o.userinfo||void 0!==o.host||void 0!==o.port||o.path||void 0!==o.query?void 0===o.scheme?o.reference="relative":void 0===o.fragment?o.reference="absolute":o.reference="uri":o.reference="same-document",n.reference&&"suffix"!==n.reference&&n.reference!==o.reference&&(o.error=o.error||"URI is not a "+n.reference+" reference.");const e=l[(n.scheme||o.scheme||"").toLowerCase()];if(!(n.unicodeSupport||e&&e.unicodeSupport)&&o.host&&(n.domainHost||e&&e.domainHost)&&!1===a&&function(e){let t=0;for(let n=0,i=e.length;n<i;++n)if(t=e.charCodeAt(n),t>126||h[t])return!0;return!1}(o.host))try{o.host=URL.domainToASCII(o.host.toLowerCase())}catch(e){o.error=o.error||"Host's domain name can not be converted to ASCII: "+e}(!e||e&&!e.skipNormalize)&&(s&&void 0!==o.scheme&&(o.scheme=unescape(o.scheme)),s&&void 0!==o.userinfo&&(o.userinfo=unescape(o.userinfo)),s&&void 0!==o.host&&(o.host=unescape(o.host)),void 0!==o.path&&o.path.length&&(o.path=escape(unescape(o.path))),void 0!==o.fragment&&o.fragment.length&&(o.fragment=encodeURI(decodeURIComponent(o.fragment)))),e&&e.parse&&e.parse(o,n)}else o.error=o.error||"URI can not be parsed.";return o}const m={SCHEMES:l,normalize:function(e,t){return"string"==typeof e?e=u(p(e,t),t):"object"==typeof e&&(e=p(u(e,t),t)),e},resolve:function(e,t,n){const i=Object.assign({scheme:"null"},n);return u(c(p(e,i),p(t,i),i,!0),{...i,skipEscape:!0})},resolveComponents:c,equal:function(e,t,n){return"string"==typeof e?(e=unescape(e),e=u(a(p(e,n),!0),{...n,skipEscape:!0})):"object"==typeof e&&(e=u(a(e,!0),{...n,skipEscape:!0})),"string"==typeof t?(t=unescape(t),t=u(a(p(t,n),!0),{...n,skipEscape:!0})):"object"==typeof t&&(t=u(a(t,!0),{...n,skipEscape:!0})),e.toLowerCase()===t.toLowerCase()},serialize:u,parse:p};e.exports=m,e.exports.default=m,e.exports.fastUri=m},343:e=>{"use strict";const t=/^[\da-f]{8}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{4}\b-[\da-f]{12}$/iu,n=/([\da-z][\d\-a-z]{0,31}):((?:[\w!$'()*+,\-.:;=@]|%[\da-f]{2})+)/iu;function i(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}function r(e){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e}function o(e){const t="https"===String(e.scheme).toLowerCase();return e.port!==(t?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}const s={scheme:"http",domainHost:!0,parse:r,serialize:o},a={scheme:"ws",domainHost:!0,parse:function(e){return e.secure=i(e),e.resourceName=(e.path||"/")+(e.query?"?"+e.query:""),e.path=void 0,e.query=void 0,e},serialize:function(e){if(e.port!==(i(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){const[t,n]=e.resourceName.split("?");e.path=t&&"/"!==t?t:void 0,e.query=n,e.resourceName=void 0}return e.fragment=void 0,e}},l={http:s,https:{scheme:"https",domainHost:s.domainHost,parse:r,serialize:o},ws:a,wss:{scheme:"wss",domainHost:a.domainHost,parse:a.parse,serialize:a.serialize},urn:{scheme:"urn",parse:function(e,t){if(!e.path)return e.error="URN can not be parsed",e;const i=e.path.match(n);if(i){const n=t.scheme||e.scheme||"urn";e.nid=i[1].toLowerCase(),e.nss=i[2];const r=`${n}:${t.nid||e.nid}`,o=l[r];e.path=void 0,o&&(e=o.parse(e,t))}else e.error=e.error||"URN can not be parsed.";return e},serialize:function(e,t){const n=t.scheme||e.scheme||"urn",i=e.nid.toLowerCase(),r=`${n}:${t.nid||i}`,o=l[r];o&&(e=o.serialize(e,t));const s=e,a=e.nss;return s.path=`${i||t.nid}:${a}`,t.skipEscape=!0,s},skipNormalize:!0},"urn:uuid":{scheme:"urn:uuid",parse:function(e,n){const i=e;return i.uuid=i.nss,i.nss=void 0,n.tolerant||i.uuid&&t.test(i.uuid)||(i.error=i.error||"UUID is not valid."),i},serialize:function(e){const t=e;return t.nss=(e.uuid||"").toLowerCase(),t},skipNormalize:!0}};e.exports=l},4914:e=>{"use strict";e.exports={HEX:{0:0,1:1,2:2,3:3,4:4,5:5,6:6,7:7,8:8,9:9,a:10,A:10,b:11,B:11,c:12,C:12,d:13,D:13,e:14,E:14,f:15,F:15}}},4834:(e,t,n)=>{"use strict";const{HEX:i}=n(4914);function r(e){if(l(e,".")<3)return{host:e,isIPV4:!1};const t=e.match(/^(?:(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])\.){3}(?:25[0-5]|2[0-4][0-9]|1[0-9][0-9]|[1-9][0-9]|[0-9])$/u)||[],[n]=t;return n?{host:a(n,"."),isIPV4:!0}:{host:e,isIPV4:!1}}function o(e,t=!1){let n="",r=!0;for(const t of e){if(void 0===i[t])return;"0"!==t&&!0===r&&(r=!1),r||(n+=t)}return t&&0===n.length&&(n="0"),n}function s(e,t={}){if(l(e,":")<2)return{host:e,isIPV6:!1};const n=function(e){let t=0;const n={error:!1,address:"",zone:""},i=[],r=[];let s=!1,a=!1,l=!1;function c(){if(r.length){if(!1===s){const e=o(r);if(void 0===e)return n.error=!0,!1;i.push(e)}r.length=0}return!0}for(let o=0;o<e.length;o++){const u=e[o];if("["!==u&&"]"!==u)if(":"!==u)if("%"===u){if(!c())break;s=!0}else r.push(u);else{if(!0===a&&(l=!0),!c())break;if(t++,i.push(":"),t>7){n.error=!0;break}o-1>=0&&":"===e[o-1]&&(a=!0)}}return r.length&&(s?n.zone=r.join(""):l?i.push(r.join("")):i.push(o(r))),n.address=i.join(""),n}(e);if(n.error)return{host:e,isIPV6:!1};{let e=n.address,t=n.address;return n.zone&&(e+="%"+n.zone,t+="%25"+n.zone),{host:e,escapedHost:t,isIPV6:!0}}}function a(e,t){let n="",i=!0;const r=e.length;for(let o=0;o<r;o++){const s=e[o];"0"===s&&i?(o+1<=r&&e[o+1]===t||o+1===r)&&(n+=s,i=!1):(i=s===t,n+=s)}return n}function l(e,t){let n=0;for(let i=0;i<e.length;i++)e[i]===t&&n++;return n}const c=/^\.\.?\//u,u=/^\/\.(?:\/|$)/u,h=/^\/\.\.(?:\/|$)/u,d=/^\/?(?:.|\n)*?(?=\/|$)/u;e.exports={recomposeAuthority:function(e,t){const n=[];if(void 0!==e.userinfo&&(n.push(e.userinfo),n.push("@")),void 0!==e.host){let t=unescape(e.host);const i=r(t);if(i.isIPV4)t=i.host;else{const n=s(i.host,{isIPV4:!1});t=!0===n.isIPV6?`[${n.escapedHost}]`:e.host}n.push(t)}return"number"!=typeof e.port&&"string"!=typeof e.port||(n.push(":"),n.push(String(e.port))),n.length?n.join(""):void 0},normalizeComponentEncoding:function(e,t){const n=!0!==t?escape:unescape;return void 0!==e.scheme&&(e.scheme=n(e.scheme)),void 0!==e.userinfo&&(e.userinfo=n(e.userinfo)),void 0!==e.host&&(e.host=n(e.host)),void 0!==e.path&&(e.path=n(e.path)),void 0!==e.query&&(e.query=n(e.query)),void 0!==e.fragment&&(e.fragment=n(e.fragment)),e},removeDotSegments:function(e){const t=[];for(;e.length;)if(e.match(c))e=e.replace(c,"");else if(e.match(u))e=e.replace(u,"/");else if(e.match(h))e=e.replace(h,"/"),t.pop();else if("."===e||".."===e)e="";else{const n=e.match(d);if(!n)throw new Error("Unexpected dot segment condition");{const i=n[0];e=e.slice(i.length),t.push(i)}}return t.join("")},normalizeIPv4:r,normalizeIPv6:s,stringArrayToHexStripped:o}},3837:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},7216:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},8226:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},518:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},4588:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},5707:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},9547:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},7082:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},1678:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},2079:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(i){var r=t[i];if(void 0!==r)return r.exports;var o=t[i]={id:i,loaded:!1,exports:{}};return e[i].call(o.exports,o,o.exports,n),o.loaded=!0,o.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var i in t)n.o(t,i)&&!n.o(e,i)&&Object.defineProperty(e,i,{enumerable:!0,get:t[i]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&"SCRIPT"===t.currentScript.tagName.toUpperCase()&&(e=t.currentScript.src),!e)){var i=t.getElementsByTagName("script");if(i.length)for(var r=i.length-1;r>-1&&(!e||!/^http(s?):/.test(e));)e=i[r--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var i=n(567);bio=i})();
8
8
  //# sourceMappingURL=package.js.map