@datagrok/bio 2.13.2 → 2.13.3

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (13) hide show
  1. package/CHANGELOG.md +7 -0
  2. package/dist/package-test.js +2 -2
  3. package/dist/package-test.js.map +1 -1
  4. package/dist/package.js +3 -3
  5. package/dist/package.js.map +1 -1
  6. package/package.json +6 -13
  7. package/src/package-types.ts +8 -15
  8. package/src/package.ts +17 -10
  9. package/src/utils/cell-renderer-consts.ts +3 -11
  10. package/src/utils/cell-renderer.ts +12 -14
  11. package/src/widgets/package-settings-editor-widget.ts +27 -27
  12. package/src/widgets/representations.ts +57 -61
  13. package/webpack.config.js +1 -1
package/dist/package.js CHANGED
@@ -1,9 +1,9 @@
1
1
  /*! For license information please see package.js.LICENSE.txt */
2
- var bio;(()=>{var e={2012:(e,t,n)=>{"use strict";n.d(t,{f:()=>r});var s=n(9976);class r extends s.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in r.aaSynonyms?r.aaSynonyms[e]:e;return super.get(t)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class i{static getPalette(e="grok"){switch(e){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",s="";for(const r of e)"("==r?t++:")"==r?t--:t?n+=r:s+=r;return isNaN(parseInt(n))?[s,n]:[s,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[s,r]=this.getInnerOuter(e);if(s=s.length>6?`${s.slice(0,3)}...`:s,r=r.length>6?`${r.slice(0,3)}...`:r,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,r,1]:[this.undefinedColor,s,r,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,r,2]:[this.undefinedColor,s,r,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,r,3]:[this.undefinedColor,s,r,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,r,4]:[this.undefinedColor,s,r,4]}return[this.undefinedColor,s,r,0]}}i.SemType="Aminoacids",i.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",i.undefinedColor="rgb(100,100,100)",i.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},i.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},i.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},i.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6584:(e,t,n)=>{"use strict";n.d(t,{BX:()=>i,nW:()=>a,tW:()=>l});var s=n(4469);const r="Libraries",i="System:AppData/Bio/monomer-libraries/";let o=Promise.resolve();async function a(){let e;return o=o.then((async()=>{const t=await s.dapi.userDataStorage.getValue(r,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[]},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await o,e}async function l(e){o=o.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await s.dapi.userDataStorage.postValue(r,"Settings",JSON.stringify(e),!0)})),await o}},7228:(e,t,n)=>{"use strict";n.d(t,{GR:()=>m,JN:()=>u,Qx:()=>h,Xk:()=>c});var s=n(976),r=n(4469),i=n(5697),o=n(1047),a=n(6286),l=(n(8607),n(8457));function c(e){const t=[];for(let n=0;n<e.rowCount;n++){const s={};Object.keys(o.K4).forEach((t=>{if("symbol"===t){const r=e.get(o.K4[t],n);s[t]="."===r?e.get(o.At,n):r}else if("rgroups"===t){const r=e.get(o.K4[t],n).split("\n"),i=[];r.forEach((e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),s=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${s}][H]`:`O[*:${s}]`,t.alternateId="H"===n?`R${s}-H`:`R${s}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${s}`,i.push(t)})),s[t]=i}else o.K4[t]&&(s[t]=e.get(o.K4[t],n))})),s.author??(s.author=""),s.id??(s.id=0),s.smiles??(s.smiles=""),s.monomerType??(s.monomerType="Backbone"),s.createDate??(s.createDate=null),t.push(s)}return t}async function u(){const e=s.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function h(e,t){e instanceof s.Column&&(e=(0,l.O)(e).columns.toList());const n=(await u()).getBioLib(),i=new Array(e.length),o=e[0].length,c=new Float32Array(o);for(let l=0;l<e.length;++l){const u=t.getCanonical(l),h=n.getMonomer("PEPTIDE",u)?.smiles??"",d=e[l],m=d.getRawData(),p=d.categories,f=p.indexOf("");if(i[l]={categories:p,data:m,emptyIndex:f},void 0===u)continue;const g=s.Column.fromStrings("smiles",p.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(s.DataFrame.fromColumns([g]),(await r.chem.getSimilarities(g,h)).getRawData());for(let e=0;e<o;++e){const t=m[e];c[e]+=u!==a.G2&&t!==f?y[t]:u===a.G2&&t===f?1:0}}for(let n=0;n<c.length;++n){let r=c[n]/t.length;for(let o=0;o<e.length;++o){const e=i[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){r=s.FLOAT_NULL;break}}c[n]=r}return s.Column.fromFloat32Array("Similarity",c)}async function d(e){const t=(await u()).getBioLib(),n=[],i={},o=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=s.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){i[e[t]]=t;const s=o[t],l=""===s?new Array(o.length).fill(0):(await r.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}async function m(e,t="Morgan"){const n=(await u()).getBioLib(),r=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),o={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??"")),l=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(e);const c=s.Column.fromStrings("smiles",a),h=(s.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await d(e);for(let t=0;t<h.length;++t)if(r[t][t]=1,o[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(r[t][e]=r[e][t]=(0,i.Z3)(h[t],h[e]));return{scoringMatrix:r,alphabetIndexes:o}}},8601:(e,t,n)=>{"use strict";n.d(t,{i0:()=>d});var s=n(4469),r=n(976),i=n(6414),o=n.n(i),a=n(1821),l=n(8607);const c={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(1047);function h(e){return Math.round(c.PRECISION_FACTOR*e)/c.PRECISION_FACTOR}async function d(e,t,i){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==r.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let h=t;const d=l.g.forColumn(t);d.isHelm()&&(h=d.convert(a.r2.SEPARATOR,"."),h.name=t.name);const p=l.g.forColumn(h).alphabet;let f;if(p===a.fb.PT||p===a.fb.UN)f="PEPTIDE";else{if(p!==a.fb.RNA&&p!==a.fb.DNA)return{col:null,warnings:[`Unexpected column's '${h.name}' alphabet '${p}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),r=l.g.forColumn(e);let i=!1;for(let e=0;e<t;++e){const t=r.getSplitted(e);i||(i=0===t.length),n[e]=o()(t.canonicals).filter((e=>!r.isGap(e))).map((e=>e)).toArray()}return i&&s.shell.warning(`Some values in the "${e.name}" column are empty`),n}(h),y=await async function(e,t,n,r){const i=function(e,t,n){const s=new Map;for(const r of e.getMonomerSymbolsByType(t)){const i=e.getMonomer(t,r);if("RNA"===t&&("Branch"===i.monomerType||n===a.fb.DNA&&i.symbol===c.DEOXYRIBOSE||n===a.fb.RNA&&i.symbol===c.RIBOSE||i.symbol===c.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==i.monomerType){const e={};u.rx.forEach((t=>{e[t]=i[t]})),s.set(i.symbol,e)}}return s}(t,n,r),o=new Map,l=await s.functions.call("Chem:getRdKitModule"),h={value:null};if("RNA"===n){const e=r===a.fb.RNA?[c.RIBOSE,c.PHOSPHATE]:[c.DEOXYRIBOSE,c.PHOSPHATE];for(const t of e)m(o,t,i,l,n,h)}for(let t=0;t<e.length;++t){const s=e[t];for(const e of s)if(""!==e)try{m(o,e,i,l,n,h)}catch(t){const n=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${s}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return o}(g,i,f,p),b=h.length,{molfileList:v,molfileWarningList:w}=await async function(e,t,s,r,i){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(n.p+n.u(286),n.b)))),l=i/o;let c=[],u=[];const h=new Array(o);for(let n=0;n<o;n++){const c=Math.floor(n*l),u=n===o-1?i:Math.floor((n+1)*l);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:s,polymerType:r,start:c,end:u}),h[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(h)).forEach((e=>{c=c.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:c,molfileWarningList:u}}(g,y,p,f,b);if(w.length>.05*b)throw new Error("Too many errors getting molfiles.");const C=`molfile(${h.name})`,A=e.columns.getUnusedName(C),S=r.Column.fromStrings(A,v);return S.semType=r.SEMTYPE.MOLECULE,S.setTag(r.TAGS.UNITS,r.UNITS.Molecule.MOLBLOCK),{col:S,warnings:w}}function m(e,t,n,s,r,i){if(!e.has(t)){const o=function(e,t,n,s,r){if(t.has(e)){const o=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(o.rgroups),l=(i=o.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let s;for(;null!==(s=n.exec(e));)s.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(s[1]),parseInt(s[3]));return t}(i):function(e){const t=new Map;let n=e.indexOf(c.V2K_A_LINE,0),s=n;for(;-1!==n;){s=e.indexOf("\n",n);const r=parseInt(e.substring(n,s).replace(/^A\s+/,""));n=e.indexOf("R",s),s=e.indexOf("\n",n);const i=parseInt(e.substring(n,s).replace(/^R/,""));t.set(r,i),n=e.indexOf(c.V2K_A_LINE,s)}for(n=e.indexOf(c.V2K_RGP_LINE,0),s=e.indexOf("\n",n);-1!==n;){n+=c.V2K_RGP_SHIFT,s=e.indexOf("\n",n);const r=e.substring(n,s).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<r.length;e+=2){if(t.has(r[e])&&t.get(r[e])!==r[e+1])throw new Error(`r-group index ${r[e]} has already been added with a different value`);t.set(r[e],r[e+1])}n=e.indexOf(c.V2K_RGP_LINE,s)}return t}(i),u=o.molfile.includes("V3000")?o.molfile:function(e,t){const n=t.get_mol(e),s=n.get_v3Kmolblock();return n.delete(),s}(function(e){let t=e.indexOf(c.V2K_A_LINE,0);-1===t&&(t=e.indexOf(c.V2K_RGP_LINE));const n=e.indexOf(c.V3K_END,t);return e.substring(0,t)+e.substring(n)}(o.molfile),n),d=function(e){let t=(e=e.replaceAll("\r","")).indexOf(c.V3K_BEGIN_COUNTS_LINE)+c.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const s=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(e.substring(t,n))}}(u),m=function(e,t){const n=new Array(t),s=new Float32Array(t),r=new Float32Array(t),i=new Array(t);let o=e.indexOf(c.V3K_BEGIN_ATOM_BLOCK);o=e.indexOf("\n",o);let a=o;for(let l=0;l<t;l++){o=e.indexOf(c.V3K_BEGIN_DATA_LINE,o)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",o),o=a+1,a=e.indexOf(" ",o),n[l]=e.substring(o,a);const t=new Array(2);for(let n=0;n<2;++n)o=a+1,a=e.indexOf(" ",o),t[n]=parseFloat(e.substring(o,a));s[l]=t[0],r[l]=t[1],o=a,a=e.indexOf("\n",o)+1,i[l]=e.slice(o,a),o=a}return{atomTypes:n,x:s,y:r,kwargs:i}}(u,d.atomCount),g=function(e,t){const n=new Uint32Array(t),s=new Array(t),r=new Map,i=new Map;let o=e.indexOf(c.V3K_BEGIN_BOND_BLOCK);o=e.indexOf("\n",o);let a=o;for(let l=0;l<t;++l){const t=new Array(3);o=e.indexOf(c.V3K_BEGIN_DATA_LINE,a)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",o);for(let n=0;n<3;++n)o=a+1,a=Math.min(e.indexOf("\n",o),e.indexOf(" ",o)),t[n]=parseInt(e.slice(o,a));n[l]=t[0],s[l]=t.slice(1);const u=e.indexOf("\n",o);let h=e.slice(a,u),d=h.indexOf(c.V3K_BOND_CONFIG);if(-1!==d){d=h.indexOf("=",d)+1;let e=h.indexOf(" ",d);-1===e&&(e=h.length);const t=parseInt(h.slice(d,e));r.set(l,t);const n=c.V3K_BOND_CONFIG+t.toString();h=h.replace(n,"")}h||i.set(l,h)}return{bondTypes:n,atomPairs:s,bondConfiguration:r,kwargs:i}}(u,d.bondCount),b=function(e,t,n,s){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[s,r]of n)e.atomTypes[s-1]=t[r-1]}(e,n,s),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const s of[1,2])if(e.get(t.rNodes[n])===s){const e=t.rNodes[s-1];t.rNodes[s-1]=t.rNodes[n],t.rNodes[n]=e}}(s,r),p(t,r),r}(m,g,a,l),S=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const s=e.indexOf(")",n);t=t.concat(e.substring(n,s).split(" ").slice(1).map((e=>parseInt(e)))),n=s,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),x={atoms:m,bonds:g,meta:b,stereoAtoms:S};return"PEPTIDE"===s?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,s=e.atoms.x,r=e.atoms.y;A(e,-s[t],-r[t]);const i=v(s[n],r[n]);w(e.atoms,-i),s[e.meta.rNodes[1]-1]<0&&function(e){C(e,!1)}(e);const o=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const s=n[e],r=n[(e+1)%2];t.has(s)?t.get(s)?.push(r):t.set(s,new Array(1).fill(r))}return t}(e);let n=0;const s=e.atoms.atomTypes.length;let r=0;for(;0===n;){const i=t.get(e.meta.terminalNodes[1])[r];if(e.atoms.atomTypes[i-1]===c.OXYGEN&&i!==e.meta.rNodes[1]&&(n=i),r++,r>s)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${s}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){C(e,!0)}(e),w(e.atoms,-function(e,t){return v(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,o),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const s=t-1,r=n-1,i=e.atoms.x,o=e.atoms.y,a=i[s],l=o[s];i[s]=i[r],o[s]=o[r],i[r]=a,o[r]=l}(e,t,e.meta.rNodes[1])}(e,o)}(x):e===c.RIBOSE||e===c.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,s=e.atoms.y;let r=e.meta.terminalNodes[0]-1;const i=e.meta.rNodes[1]-1;A(e,-n[r],-s[r]);const o=v(n[i],s[i]);w(e.atoms,3*Math.PI/2-o),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,s=e.meta.rNodes[2]-1,r=e.meta.terminalNodes[2]-1,i=t[s]-t[r],o=n[s]-n[r];return Math.atan(o/i)+Math.PI/2}(e),r=e.meta.terminalNodes[0]-1,A(e,-n[r],-s[r])}(x,r):e===c.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,s=e.atoms.x,r=e.atoms.y;A(e,-s[t],-r[t]);const i=v(s[n],r[n]);w(e.atoms,Math.PI/2-i)}(x):function(e,t){const n=e.atoms.x,s=e.atoms.y,r=e.meta.terminalNodes[0]-1,i=e.meta.rNodes[0]-1;A(e,-n[r],-s[r]);const o=v(n[i],s[i]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");w(e.atoms,Math.PI-o+a);const l=function(e,t){return h(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:s[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:s[e.meta.terminalNodes[0]-1]});if(1!=l)for(let e=0;e<n.length;++e)n[e]=h(n[e]/l),s[e]=h(s[e]/l)}(x,r),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===c.RIBOSE||n===c.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],p(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===c.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],A(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(s,x,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===c.HYDROGEN&&(y(e,t+1),--t),++t}(x),x}var i;return null}(t,n,s,r,i);if(!o)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,o)}}function p(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const s=t.terminalNodes,r=e.atomPairs;let i=0,o=0;for(;i<r.length&&o<s.length;){for(let e=0;e<s.length;++e)for(let t=0;t<2;++t)r[i][t]===n[e]&&(s[e]=r[i][(t+1)%2],n.length,++o);++i}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[h(e.atoms.x[t]-e.atoms.x[n]),h(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,s=e.atoms,r=e.bonds,i=e.meta;s.atomTypes.splice(n,1),s.x=b(Float32Array,s.x,n,1),s.y=b(Float32Array,s.y,n,1),s.kwargs.splice(n,1);for(let e=0;e<i.terminalNodes.length;++e)i.terminalNodes[e]>t?--i.terminalNodes[e]:i.terminalNodes[e]===t&&(i.terminalNodes[e]=-1);for(let e=0;e<i.rNodes.length;++e)i.rNodes[e]>t?--i.rNodes[e]:i.rNodes[e]===t&&(i.rNodes[e]=-1);let o=0;for(;o<r.atomPairs.length;){const e=r.atomPairs[o][0],n=r.atomPairs[o][1];e===t||n===t?(r.atomPairs.splice(o,1),r.bondTypes=b(Uint32Array,r.bondTypes,o,1),r.bondConfiguration.has(o)&&r.bondConfiguration.delete(o),r.kwargs.has(o)&&r.kwargs.delete(o),--o):(r.atomPairs[o][0]=e>t?e-1:e,r.atomPairs[o][1]=n>t?n-1:n),++o}let a=Array.from(r.bondConfiguration.keys());a.forEach((e=>{if(r.bondConfiguration.has(e)&&e>n){const t=r.bondConfiguration.get(e);r.bondConfiguration.delete(e),r.bondConfiguration.set(e-1,t)}})),a=Array.from(r.kwargs.keys()),a.forEach((e=>{if(r.kwargs.has(e)&&e>n){const t=r.kwargs.get(e);r.kwargs.delete(e),r.kwargs.set(e-1,t)}}))}}function b(e,t,n,s){const r=new e(t.length-s);let i=0,o=0;for(;i<t.length;)i===n&&(i+=s),r[o]=t[i],++o,++i;return r}function v(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const s=t/e,r=Math.atan(s);n=e<0?Math.PI/2+r:-Math.PI/2+r}return n}function w(e,t){if(0!==t){const n=e.x,s=e.y,r=Math.cos(t),i=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=h(t*r-s[e]*i),s[e]=h(t*i+s[e]*r)}}}function C(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const s=1===t?3:1;n.set(e,s)}}function A(e,t,n){const s=e.atoms.x,r=e.atoms.y;for(let e=0;e<s.length;++e)s[e]=h(s[e]+t),void 0!==n&&(r[e]=h(r[e]+n))}},6137:(e,t,n)=>{"use strict";n.d(t,{J:()=>r});var s=n(9976);class r extends s.B{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new r({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},9976:(e,t,n)=>{"use strict";n.d(t,{B:()=>s});class s{static makePalette(e,t=!1,n=s){const r={};return e.forEach((e=>{const n=e[0],s=e[1];n.forEach(((e,n)=>{r[e]=this.colourPalette[s][t?0:n]}))})),new n(r)}constructor(e){this._palette=e}get(e){return this._palette[e]}}s.undefinedColor="rgb(100,100,100)",s.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},7331:(e,t,n)=>{"use strict";n.d(t,{UE:()=>c});var s=n(976),r=n(9976);class i{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class o{}class a extends o{get(e){return"#666666"}}class l extends o{static buildPalette(){return[].concat(...Object.values(r.B.colourPalette))}get(e){const t=i.hashCode(e)%l.palette.length;return function(e){if(null==e)return"rgb(100,100,100)";const t=s.Color.fromHtml(e),n=s.Color.g(t),r=s.Color.r(t),i=s.Color.b(t),o=Math.sqrt(Math.pow(0-r,2)+Math.pow(0-n,2)+Math.pow(0-i,2));return o>210?`rgb(${r/o*210},${n/o*210},${i/o*210})`:s.Color.toRgb(t)}(l.palette[t])}}l.palette=l.buildPalette();class c extends r.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},9713:(e,t,n)=>{"use strict";n.d(t,{N:()=>o,b:()=>a});var s=n(4469),r=n(701),i=n(2997);function o(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const s=e.cell.column;if(t=t??s.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,s,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.reset(),this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{try{this.reset()}catch(e){this.logger.error(e)}}))),this.tableCol&&this.subs.push(s.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(s.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,i.zg)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},9611:(e,t,n)=>{"use strict";n.d(t,{A:()=>c});var s=n(976),r=n(6414),i=n.n(r),o=n(8607),a=n(9713),l=n(7228);class c extends a.b{constructor(e,t,n,r,i){super(e,t,n),this.monomerLengthLimit=r,this.propsProvider=i,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=s.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,l.JN)().then((e=>{if(this.destroyed)return;const t=e.getBioLib();this.subs.push(t.onChanged.subscribe((()=>{this.reset(),this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=s.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={}}getCellMonomerLengths(e,t){this.colWidth<t&&(this.colWidth=t,this.reset());const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),s=new Array(n.length+1);s[0]=5;for(let e=1;e<s.length;e++)s[e]=s[e-1]+n[e-1];return[n,s]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),s=o.g.forColumn(this.tableCol).getSplitted(e).originals,r=Math.min(n,s.length);let i=this._monomerLengthList[e];if(null===i||i.length<r){i=this._monomerLengthList[e]=new Array(s.length);let t=0;for(let e=0;e<r;++e){const n=s[e],r=this.props.monomerToShort(n,this.monomerLengthLimit),o=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.monomerCharWidth;if(i[e]=o,t+=o,t>this.colWidth)break}}return i}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:s}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.monomerCharWidth,i=Math.ceil(this.colWidth/r);for(let e=n;e<s;e++){if(this._processedRows.get(e)&&i<=this._processedMaxVisibleSeqLength)continue;const n=o.g.forColumn(this.tableCol).getSplitted(e,i).originals,s=Math.min(i,n.length);s>t.length&&t.push(...new Array(s-t.length).fill(r));let a=0;for(let e=0;e<s;++e){const s=n[e],r=this.props.monomerToShort(s,this.monomerLengthLimit),i=this.props.separatorWidth+r.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,i),a+=i,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,i)}return t}getPosition(e,t,n){const[s,r]=this.getCellMonomerLengths(e,n),a=o.g.forColumn(this.tableCol);return 0===i()(a.getSplitted(e).originals).toArray().length?null:function(e,t){let n,s=100,r=0,i=e.length-1;for(;r<=i;){if(n=Math.floor((i+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?i=n-1:r=n+1,--s<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.reset()}setSeparatorWidth(e){this.props.separatorWidth=e,this.reset()}isMsa(){return this.props.seqHandler.isMsa()}}},1047:(e,t,n)=>{"use strict";n.d(t,{$3:()=>o,At:()=>r,K4:()=>i,pU:()=>a,rx:()=>s});const s=["symbol","molfile","rgroups","name"],r="MonomerName",i={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},o="p",a=new RegExp(`[rd]\\((\\w)\\)${o}?`,"g")},7945:(e,t,n)=>{"use strict";function s(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?s(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function r(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):void 0}function i(e){return[s(e),r(e)]}n.d(t,{yf:()=>i})},5226:(e,t,n)=>{"use strict";n.d(t,{i:()=>o});var s=n(976),r=n(8607),i=n(1821);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const s=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(s),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=s.Column.fromStrings("description",this.descriptionsArray),t=s.Column.fromStrings("sequence",this.sequencesArray);return t.semType=s.SEMTYPE.MACROMOLECULE,t.setTag(s.TAGS.UNITS,i.r2.FASTA),r.g.forColumn(t),[s.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},706:(e,t,n)=>{"use strict";n.d(t,{io:()=>c,wl:()=>u});var s=n(976),r=n(6414),i=n.n(r),o=n(8447),a=n(8607),l=n(8260);function c(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=s.SEMTYPE.MACROMOLECULE,n.setTag(s.TAGS.UNITS,o.r2.SEPARATOR),n.setTag(o.DX.separator,"/"),n.setTag(o.DX.alphabet,o.fb.UN),n.setTag(o.DX.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(s.Column.fromList(s.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function u(e=o.r2.SEPARATOR,t=o.fb.PT,n=(e===o.r2.SEPARATOR?"-":void 0),r=undefined,c="seq",u=100,h=10**6){const d=t===o.fb.UN?r?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,o.gM)(t)),m=d.length,p=s.Column.fromType(s.COLUMN_TYPE.STRING,c,u);p.semType=s.SEMTYPE.MACROMOLECULE,p.setTag(s.TAGS.UNITS,e),p.setTag(o.DX.alphabet,t),e==o.r2.SEPARATOR&&p.setTag(o.DX.separator,n);const f=a.g.forColumn(p);for(let t=0;t<u;t++){const n=i().count(0).take(h).map((e=>d[Math.floor(Math.random()*m)])).toArray(),s=f.joiner(new l.wx(n,a.lh[e]));p.set(t,s)}return p}},1821:(e,t,n)=>{"use strict";n.d(t,{BM:()=>l,CI:()=>a,DX:()=>i,XS:()=>u,fb:()=>r,r2:()=>s,se:()=>c});var s,r,i,o=n(6286);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(s||(s={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(r||(r={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(i||(i={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new o.LA(r.PT,c.fasta.peptide,.5),new o.LA(r.DNA,c.fasta.dna,.55),new o.LA(r.RNA,c.fasta.rna,.55)]},8447:(e,t,n)=>{"use strict";n.d(t,{Ar:()=>r.Ar,CI:()=>s.CI,DX:()=>s.DX,GU:()=>r.GU,XS:()=>s.XS,dQ:()=>r.dQ,fb:()=>s.fb,gM:()=>r.gM,gP:()=>r.gP,kB:()=>r.kB,py:()=>r.py,r2:()=>s.r2,up:()=>r.up});var s=n(1821),r=n(8260)},6286:(e,t,n)=>{"use strict";n.d(t,{G2:()=>s,LA:()=>r,dJ:()=>i});const s="";class r{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class i extends r{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},8260:(e,t,n)=>{"use strict";n.d(t,{wx:()=>p,w4:()=>T,gM:()=>E,py:()=>_,vU:()=>A,Ar:()=>b,GU:()=>x,dQ:()=>I,up:()=>M,kB:()=>g,FJ:()=>y,gP:()=>C});var s=n(976),r=n(6414),i=n.n(r),o=n(6286),a=n(1821),l=n(8607);class c extends Float32Array{}var u=n(850),h=n(2012),d=n(6137),m=n(7331);class p{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===l.lh[a.r2.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?o.G2:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}const g=e=>{const t=i()(e.toString().matchAll(a.BM)).map((e=>e[2]??e[1])).toArray();return new p(t,l.lh[a.r2.FASTA])},y=e=>e?new f(e):new p([],l.lh[a.r2.FASTA]);function b(e,t=undefined){return n=>{if(n){let s;const r=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){r.lastIndex=0,s=new Array(Math.ceil(t));let e=null,i=0;for(;null!==(e=r.exec(n))&&i<t;)s[i++]=e[0].replace('"-"',"").replace("'-'","");s.splice(i)}else s=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new p(s,l.lh[a.r2.SEPARATOR])}return new p([],l.lh[a.r2.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g,C=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,s=n?n.split("."):[];return new p(s.map((e=>{w.lastIndex=0;const t=w.exec(e);return t&&t.length>=2?t[1]:e})),l.lh[a.r2.HELM])};function A(e,t,n=undefined){if(e.toLowerCase().startsWith(a.r2.FASTA))return g;if(e.toLowerCase().startsWith(a.r2.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.r2.HELM))return C;throw new Error(`Unexpected units ${e} .`)}const S=/([^\W_]+)/g;function x(e,t){if(e.length<=t)return e;const n=e.match(S),s=e.length>t||(n?.length??0)>1,r=n?.[0]??" ";return s?r.substring(0,t-1)+"…":r}function E(e){switch(e){case a.fb.DNA:return a.se.fasta.dna;case a.fb.RNA:return a.se.fasta.rna;case a.fb.PT:return a.se.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function T(e,t,n="-"){const s=t.map((t=>{const s=function(e,t,n="-"){const s=new Set([...new Set(Object.keys(e)),...t]);s.delete(n);const r=[],i=[];for(const n of s)r.push(n in e?e[n]:0),i.push(t.has(n)?1:0);const o=new c(r),a=new c(i);return(0,u.MA)(o,a)/((0,u.$G)(o)*(0,u.$G)(a))}(e,t.alphabet,n);return new o.dJ(t,e,s)}));let r;const i=Math.max(...s.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return r=i>0?s.find((e=>e.similarity===i)).name:a.fb.UN,r}function I(e,t=5){let n;if(e.semType==s.SEMTYPE.MACROMOLECULE)n=l.g.forColumn(e).alphabet;else{const s=function(e,t,n){const s=e.categories;return function(e,t){const n={};let s=!0,r=null;for(const i of e)if(null==r?r=i.length:i.length!==r&&(s=!1),i.length>=t)for(const e of i.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:s}}(i().enumerate(e.getRawData()).map((([e,t])=>n(s[e]))),t)}(e,t,g);n=T(s.freq,a.XS)}return _(n)}function _(e){switch(e){case a.fb.PT:return h.f.GrokGroups;case a.fb.DNA:case a.fb.RNA:return d.J.Chromatogram;default:return m.UE.Color}}function M(e){const t=e.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.getTag(s.TAGS.UNITS);return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},8607:(e,t,n)=>{"use strict";n.d(t,{dm:()=>d,g:()=>p,lh:()=>m});var s=n(976),r=n(6414),i=n.n(r),o=n(8447),a=n(6286),l=n(8260),c=n(708),u=n(7228),h=n(1047);const d=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},m={[o.r2.FASTA]:"-",[o.r2.SEPARATOR]:"",[o.r2.HELM]:"*"};class p{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;const t=this._column.getTag(s.TAGS.UNITS);if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?m[o.r2.FASTA]:this.isHelm()?m[o.r2.HELM]:m[o.r2.SEPARATOR],!this.column.tags.has(o.DX.aligned)||!this.column.tags.has(o.DX.alphabet)||!this.column.tags.has(o.DX.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===o.fb.UN)if(this.isFasta())p.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(o.DX.separator);p.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(s.TAGS.UNITS)}'.`);p.setUnitsToHelmColumn(this)}if(!this.column.tags.has(o.DX.alphabetIsMultichar))if(this.isHelm())this.column.setTag(o.DX.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${o.DX.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[d.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.getTag(s.TAGS.UNITS)!==o.r2.FASTA)throw new Error(`The column of notation '${o.r2.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.setTag(s.TAGS.UNITS,o.r2.FASTA),p.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.getTag(s.TAGS.UNITS)!==o.r2.SEPARATOR)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must have the separator tag.`);e.column.setTag(s.TAGS.UNITS,o.r2.SEPARATOR),e.column.setTag(o.DX.separator,t),p.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.r2.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.setTag(s.TAGS.UNITS,o.r2.HELM),p.setTags(e)}static setTags(e){const t=e.column.getTag(s.TAGS.UNITS);if([o.r2.FASTA,o.r2.SEPARATOR].includes(t)){if(!e.column.getTag(o.DX.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(o.DX.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(o.DX.aligned,t));let n=e.column.getTag(o.DX.alphabet);if(null===n&&(n=(0,l.w4)(e.stats.freq,o.XS),e.column.setTag(o.DX.alphabet,n)),n===o.fb.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(o.DX.alphabetSize,t.toString()),e.column.setTag(o.DX.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(o.DX.separator)??void 0;if(this.notation===o.r2.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(o.DX.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(o.DX.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(o.DX.isHelmCompatible)}getAlphabetSize(){if(this.notation==o.r2.HELM||this.alphabet==o.fb.UN){const e=this.column.getTag(o.DX.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case o.fb.PT:return 20;case o.fb.DNA:case o.fb.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.r2.HELM||this.alphabet===o.fb.UN&&"true"===this.column.getTag(o.DX.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const s=this.column.length;for(let r=0;r<s;++r){const s=this.getSplitted(r);null==n?n=s.length:s.length!==n&&(t=!1);for(const t of s.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...i().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(o.DX.positionNames);this._posList=e?e.split(o.CI).map((e=>e.trim())):i().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.r2.FASTA}isSeparator(){return this.notation===o.r2.SEPARATOR}isHelm(){return this.notation===o.r2.HELM}isRna(){return this.alphabet===o.fb.RNA}isDna(){return this.alphabet===o.fb.DNA}isPeptide(){return this.alphabet===o.fb.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return o.r2.FASTA;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return o.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,r){const i=this.column,a=e.toLowerCase()+"("+i.name+")",l=n??i.dataFrame.columns.getUnusedName(a),c=s.Column.fromList("string",l,r??new Array(this.column.length).fill(""));if(c.semType=s.SEMTYPE.MACROMOLECULE,c.setTag(s.TAGS.UNITS,e),e===o.r2.SEPARATOR){if(!t)throw new Error(`Notation '${o.r2.SEPARATOR}' requires separator value.`);c.setTag(o.DX.separator,t)}c.setTag(s.TAGS.CELL_RENDERER,e===o.r2.HELM?"helm":"sequence");const u=i.getTag(o.DX.aligned);u&&c.setTag(o.DX.aligned,u);let h=i.getTag(o.DX.alphabet);h||this.notation!==o.r2.HELM||e===o.r2.HELM||(h=o.fb.UN),null!=h&&c.setTag(o.DX.alphabet,h);let d=i.getTag(o.DX.alphabetSize);null!=h&&d&&c.setTag(o.DX.alphabetSize,d);const m=i.getTag(o.DX.alphabetIsMultichar);return null!=h&&void 0!==m&&c.setTag(o.DX.alphabetIsMultichar,m),e==o.r2.HELM&&(d=this.getAlphabetSize().toString(),c.setTag(o.DX.alphabetSize,d)),c}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=p.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[o.r2.FASTA,o.r2.SEPARATOR,o.r2.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!p.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const r=s.Column.fromList("string",t,new Array(e).fill(""));return r.semType=s.SEMTYPE.MACROMOLECULE,r.setTag(s.TAGS.UNITS,n),r}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(o.r2.FASTA))return null===this.column.getTag(o.DX.alphabet)||this.getAlphabetIsMultichar()?o.kB:l.FJ;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return(0,o.Ar)(this.separator,e);if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.gP;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return c.U.HAMMING;switch(this.alphabet){case o.fb.DNA:case o.fb.RNA:case o.fb.PT:}return c.U.LEVENSHTEIN}getDistanceFunction(){return c.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(o.DX.isHelmCompatible))return"true"===this.column.getTag(o.DX.isHelmCompatible);const e=(await(0,u.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,o.Ar)(this.separator),new Set),s=this.column.length,r=this.column.getRawData();for(let e=0;e<s;++e){const s=r[e];if(!(s in n)){n.add(s);const r=this.getSplitted(e);for(const e of r.canonicals)if(!t.has(e))return this.column.setTag(o.DX.isHelmCompatible,"false"),!1}}return this.column.setTag(o.DX.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===o.r2.FASTA}toSeparator(e){return e===o.r2.SEPARATOR}toHelm(e){return e===o.r2.HELM}convertHelmToFastaSeparator(e,t,n,s){s||(s=this.toFasta(t)?m[o.r2.FASTA]:m[o.r2.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),i=this.splitter(e),a=[];for(let e=0;e<i.length;++e){let n=i.getOriginal(e);if(r&&(n=n.replace(h.pU,"")),n===m[o.r2.HELM])a.push(s);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),s=this.getNewColumn(e,t);return s.init((e=>{const t=this.getSplitted(e);return n(t)})),s}getRegion(e,t,n){const s=this.getNewColumn(this.notation,this.separator);s.name=n;const r=e??0,i=t??this.maxLength-1,a=this.getJoiner(),c=i-r+1,u=m[this.notation];s.init((e=>{const t=this.getSplitted(e),n=new Array(c);for(let e=0;e<c;++e){const s=r+e;n[e]=s<t.length?t.getOriginal(s):u}return a(new l.wx(n,u))}));const h=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(c);for(let e=0;e<c;++e){const s=r+e;n[e]=s<t.length?t[s]:"?"}return n.join(o.CI)},d=this.column.getTag(o.DX.positionNames);d&&s.setTag(o.DX.positionNames,h(d));const p=this.column.getTag(o.DX.positionLabels);return p&&s.setTag(o.DX.positionLabels,h(p)),s}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let s;const r=this;switch(t){case o.r2.FASTA:s=function(e){return r.joinToFasta(e,r.isHelm())};break;case o.r2.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);s=function(e){return f(e,n,r.isHelm())};break;case o.r2.HELM:{const e=r.alphabet===o.fb.DNA||r.alphabet===o.fb.RNA,t=r.getHelmWrappers();s=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return s}getConverter(e,t=undefined){if(e===o.r2.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const n=this;if(e===o.r2.FASTA)return function(e){return n.convertToFasta(e)};if(e===o.r2.HELM)return function(e){return n.convertToHelm(e)};if(e===o.r2.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[d.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[d.seqHandler]=new p(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let s=0;s<e.length;++s){const r=e.getOriginal(s);let i=e.getOriginal(s);t&&(i=i.replace(h.pU,"$1")),r===a.G2?i=m[o.r2.FASTA]:r===h.$3?i="":i.length>1&&(i="["+i+"]"),n[s]=i}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),s=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let i=t.getOriginal(e);(s||r)&&(i=i.replace(h.pU,"$1"),i=i===h.$3?null:i),n[e]=i||null}return new l.wx(n.filter((e=>!!e)),m[o.r2.HELM])}}function f(e,t,n){const s=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let i=e.getOriginal(t);n&&(i=i.replace(h.pU,"$1")),r===a.G2?i=m[o.r2.SEPARATOR]:r===h.$3&&(i=""),s[t]=i}return s.join(t)}function g(e,t,n){const[s,r,i,l]=t,c=new Array(e.length);for(let t=0;t<e.length;++t){const s=e.getCanonical(t);let l=e.getOriginal(t);s===a.G2?l=m[o.r2.HELM]:(n&&(l=l.replace(h.pU,"$1")),l=1===l.length?`${r}${l}${i}`:`${r}[${l}]${i}`),c[t]=l}return`${s}${c.join(".")}${l}`}},8457:(e,t,n)=>{"use strict";n.d(t,{O:()=>i});var s=n(976),r=n(8607);function i(e){const t=e=>{const t=o.columns.addNewString((e+1).toString());return n.push(t),t},n=[],i=e.length,o=s.DataFrame.create(i),a=r.g.forColumn(e);for(let e=0;e<i;++e){const s=a.getSplitted(e);for(let r=0;r<s.length;++r){const i=s.getOriginal(r);((n[r]??null)||t(r)).set(e,i,!1)}}return o}},172:(e,t,n)=>{"use strict";n.d(t,{c:()=>i});var s,r=n(7945);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(s||(s={}));class i{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[s,i]=(0,r.yf)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${s}`,void 0,i),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},9298:(e,t,n)=>{"use strict";n.d(t,{Ct:()=>l,DX:()=>s,ES:()=>r,dE:()=>a,iD:()=>o,vS:()=>u,vw:()=>i});var s,r,i,o,a,l,c=n(976);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(s||(s={})),function(e){e.Entropy="Entropy",e.full="100%"}(r||(r={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(i||(i={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(o||(o={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(l||(l={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=16,this.verticalAlignment=i.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},7905:(e,t,n)=>{"use strict";e=n.hmd(e);var s,r=(s="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,r=void 0!==e?e:{};r.ready=new Promise((function(e,s){t=e,n=s}));var i,o=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),s&&(c=s),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(i=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),r.print||console.log.bind(console);var u,h,d=r.printErr||console.warn.bind(console);Object.assign(r,o),o=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(u=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&x("no native wasm support detected");var m,p,f,g=!1;function y(){var e=h.buffer;r.HEAP8=m=new Int8Array(e),r.HEAP16=new Int16Array(e),r.HEAP32=new Int32Array(e),r.HEAPU8=p=new Uint8Array(e),r.HEAPU16=new Uint16Array(e),r.HEAPU32=f=new Uint32Array(e),r.HEAPF32=new Float32Array(e),r.HEAPF64=new Float64Array(e)}var b=[],v=[],w=[],C=0,A=null,S=null;function x(e){r.onAbort&&r.onAbort(e),d(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var E,T,I="data:application/octet-stream;base64,";function _(e){return e.startsWith(I)}function M(e){try{if(e==E&&u)return new Uint8Array(u);if(i)return i(e);throw"both async and sync fetching of the wasm failed"}catch(e){x(e)}}function $(e,t,n){return function(e){return u||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return M(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return M(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){d("failed to asynchronously prepare wasm: "+e),x(e)}))}function N(e){for(;e.length>0;)e.shift()(r)}function L(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,m[this.ptr+12>>0]=e},this.get_caught=function(){return 0!=m[this.ptr+12>>0]},this.set_rethrown=function(e){e=e?1:0,m[this.ptr+13>>0]=e},this.get_rethrown=function(){return 0!=m[this.ptr+13>>0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(U(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function P(e){var t=h.buffer;try{return h.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function R(e){return r["_"+e]}_(E="wasmDbscan.wasm")||(T=E,E=r.locateFile?r.locateFile(T,c):c+T);var O="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function k(e,t,n,s,r){var i={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var s=e.charCodeAt(n);s<=127?t++:s<=2047?t+=2:s>=55296&&s<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=V(t);return function(e,t,n){!function(e,t,n,s){if(!(s>0))return 0;for(var r=n+s-1,i=0;i<e.length;++i){var o=e.charCodeAt(i);if(o>=55296&&o<=57343&&(o=65536+((1023&o)<<10)|1023&e.charCodeAt(++i)),o<=127){if(n>=r)break;t[n++]=o}else if(o<=2047){if(n+1>=r)break;t[n++]=192|o>>6,t[n++]=128|63&o}else if(o<=65535){if(n+2>=r)break;t[n++]=224|o>>12,t[n++]=128|o>>6&63,t[n++]=128|63&o}else{if(n+3>=r)break;t[n++]=240|o>>18,t[n++]=128|o>>12&63,t[n++]=128|o>>6&63,t[n++]=128|63&o}}t[n]=0}(e,p,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,s=V(e.length);return t=e,n=s,m.set(t,n),s}},o=R(e),a=[],l=0;if(s)for(var c=0;c<s.length;c++){var u=i[n[c]];u?(0===l&&(l=G()),a[c]=u(s[c])):a[c]=s[c]}var h=o.apply(null,a);return function(e){return 0!==l&&B(l),function(e){return"string"===t?(n=e)?function(e,t,n){for(var s=t+n,r=t;e[r]&&!(r>=s);)++r;if(r-t>16&&e.buffer&&O)return O.decode(e.subarray(t,r));for(var i="";t<r;){var o=e[t++];if(128&o){var a=63&e[t++];if(192!=(224&o)){var l=63&e[t++];if((o=224==(240&o)?(15&o)<<12|a<<6|l:(7&o)<<18|a<<12|l<<6|63&e[t++])<65536)i+=String.fromCharCode(o);else{var c=o-65536;i+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else i+=String.fromCharCode((31&o)<<6|a)}else i+=String.fromCharCode(o)}return i}(p,n,s):"":"boolean"===t?Boolean(e):e;var n,s}(e)}(h)}var D,F={__cxa_throw:function(e,t,n){throw new L(e).init(t,n),e},abort:function(){x("")},emscripten_memcpy_big:function(e,t,n){p.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=p.length,s=2147483648;if((e>>>=0)>s)return!1;for(var r=1;r<=4;r*=2){var i=n*(1+.2/r);if(i=Math.min(i,e+100663296),P(Math.min(s,(t=Math.max(e,i))+(65536-t%65536)%65536)))return!0}return!1}},G=(function(){var e,t,s,i,o={env:F,wasi_snapshot_preview1:F};function a(e,t){var n,s=e.exports;return r.asm=s,h=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,v.unshift(n),function(e){if(C--,r.monitorRunDependencies&&r.monitorRunDependencies(C),0==C&&(null!==A&&(clearInterval(A),A=null),S)){var t=S;S=null,t()}}(),s}if(C++,r.monitorRunDependencies&&r.monitorRunDependencies(C),r.instantiateWasm)try{return r.instantiateWasm(o,a)}catch(e){d("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=E,s=o,i=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||_(t)||"function"!=typeof fetch?$(t,s,i):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,s).then(i,(function(e){return d("wasm streaming compile failed: "+e),d("falling back to ArrayBuffer instantiation"),$(t,s,i)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(G=r.asm.stackSave).apply(null,arguments)}),B=function(){return(B=r.asm.stackRestore).apply(null,arguments)},V=function(){return(V=r.asm.stackAlloc).apply(null,arguments)},U=function(){return(U=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function H(){function e(){D||(D=!0,r.calledRun=!0,g||(N(v),t(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)e=r.postRun.shift(),w.unshift(e);var e;N(w)}()))}C>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)e=r.preRun.shift(),b.unshift(e);var e;N(b)}(),C>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),e()}),1)):e()))}if(r.ccall=k,r.cwrap=function(e,t,n,s){var r=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&r&&!s?R(e):function(){return k(e,t,n,arguments)}},S=function e(){D||H(),D||(S=e)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return H(),e.ready});"object"==typeof exports?e.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6254:(e,t,n)=>{"use strict";function s(e){return(t,n)=>e*t+n-Math.floor((t+2)*(t+1)/2)}n.d(t,{y:()=>s})},5697:(e,t,n)=>{"use strict";n.d(t,{Dz:()=>b,FV:()=>c,Jv:()=>S,KR:()=>l,MI:()=>w,NB:()=>p,UX:()=>m,WI:()=>d,Z3:()=>a,Zd:()=>h,_h:()=>u,aW:()=>g,bX:()=>A,fX:()=>v,kg:()=>o,s:()=>f,yU:()=>y});var s=n(9657),r=n(1040),i=n(708);r.gk.Tanimoto,r.gk.Dice,r.gk.Asymmetric,r.gk.BraunBlanquet,r.gk.Cosine,r.gk.Kulczynski,r.gk.McConnaughey,r.gk.RogotGoldberg,r.gk.Russel,r.gk.Sokal,r.gk.Hamming,r.gk.Euclidean,r.gk.Tanimoto,r.gk.Dice,r.gk.Asymmetric,r.gk.BraunBlanquet,r.gk.Cosine,r.gk.Kulczynski,r.gk.McConnaughey,r.gk.RogotGoldberg,r.gk.Russel,r.gk.Sokal,r.gk.Hamming,r.gk.Euclidean;const o=[r.gk.Tanimoto,r.gk.Dice,r.gk.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const s=e.andWithCountBits(t,!0);return s/(n-s)}function l(e,t){return 1-a(e,t)}function c(e,t){return C(a(new s.Z(e,32*e.length),new s.Z(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function h(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function d(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function m(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function p(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),s=e.andWithCountBits(t,!0);return s/(2*n-3*s)}(e,t)}function f(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),s=e.trueCount()*t.trueCount();return 0==s?0:e.andWithCountBits(t,!0)*n/(2*s)}(e,t))}function g(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),s=e.trueCount()*t.trueCount();return 0==s?0:(e.andWithCountBits(t,!0)*n-s)/s}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function b(e,t){return C(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function v(e,t){return C(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function w(e,t){return C(function(e,t){const n=e.andWithCountBits(t,!0),s=e.countBits(!0)+t.countBits(!0),r=e.length,i=r-s+n;return n==r||i==r?1:n/s+i/(2*r-s)}(e,t))}function C(e){return 0===e?3402823e32:1/e-1}function A(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function S(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const s=e.length,r=n.length;let i=0,o=0,a=0;for(;o<s&&a<r;)e[o]===n[a]?(t?.has(e[o])||++i,++o,++a):e[o]<n[a]?++o:++a;return i}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}r.gk.Tanimoto,r.gk.Asymmetric,r.gk.Cosine,r.gk.Sokal,i.U.HAMMING,i.U.LEVENSHTEIN,i.U.MONOMER_CHEMICAL_DISTANCE,i.U.NEEDLEMANN_WUNSCH},3277:(e,t,n)=>{"use strict";n.d(t,{Ec:()=>c,dB:()=>a,n3:()=>s,q6:()=>o,sS:()=>l,ts:()=>i,vO:()=>r});const s="dim-red-preprocessing-function",r="supportedSemTypes",i="supportedTypes",o="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},708:(e,t,n)=>{"use strict";function s(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,s=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,r=new Float32Array((n.length+s)*(n.length+s));return Object.entries(t).forEach((([e,s])=>{const i=n[s];Object.entries(t).forEach((([t,s])=>{r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=i[s]}))})),(e,t)=>1-r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,s)=>{let r=0;const i=e.length,o=s.length,a=Math.ceil(Math.max(i,o)*(1-n));i!==o&&(r=Math.abs(i-o));let l=0;for(let n=0;n<Math.min(i,o);n++)if(e[n]!==s[n]&&(l+=t(e[n],s[n]),l>a))return 1;return l+=r,l/=Math.max(i,o),l}}n.d(t,{U:()=>o,o:()=>a});var r=n(1811);const i={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var o;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(o||(o={}));const a={[o.HAMMING]:s,[o.LEVENSHTEIN]:function(){return(e,t)=>(0,r.T)(e,t)/Math.max(e.length,t.length)},[o.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:s,scoringMatrix:r,alphabetIndexes:o}={...i,...e};Object.entries(o).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,i)=>{const o=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-n-(t-1)*s,a[1][t]=0;a[0][0]=0;for(let h=1;h<i.length+1;h++){a[u][0]=-n-(h-1)*s;for(let d=1;d<e.length+1;d++){const m=a[c][d-1]+r[t[e.charCodeAt(d-1)]][t[i.charCodeAt(h-1)]],p=a[c][d]-(o[d]?s:n),f=a[u][d-1]-(l[d-1]?s:n);a[u][d]=Math.max(m,f,p),a[u][d]===m?(o[d]=!1,l[d]=!1):a[u][d]===f?(o[d]=!1,l[d]=!0):(o[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.max(e.length,i.length);return(h-a[c][e.length])/h}},[o.MONOMER_CHEMICAL_DISTANCE]:s}},4628:(e,t,n)=>{"use strict";var s;n.d(t,{A:()=>s}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(s||(s={}))},1040:(e,t,n)=>{"use strict";var s,r,i,o,a,l,c;n.d(t,{CF:()=>r,Qe:()=>a,W:()=>s,Yc:()=>l,gd:()=>o,gj:()=>c,gk:()=>i}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(s||(s={})),function(e){e.Euclidean="Euclidean"}(r||(r={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(i||(i={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(o||(o={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(l||(l={})),function(e){e.CommonItems="Common Items"}(c||(c={}))},6361:(e,t,n)=>{"use strict";n.d(t,{W:()=>s.W});var s=n(1040);n(7861)},7861:(e,t,n)=>{"use strict";var s=n(1811),r=n(3979),i=n(5697),o=n(850),a=n(708),l=n(1040);const c={[l.CF.Euclidean]:o.dP},u={[l.W.Levenshtein]:s.T,[l.W.JaroWinkler]:r.H$,[l.W.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let s=1;s<e.length;s++)n+=e[s]==t[s]?0:1;return n/e.length}},[l.W.Onehot]:function(e,t){return e===t?0:1}},h={[l.gk.Tanimoto]:i.KR,[l.gk.Dice]:i._h,[l.gk.Asymmetric]:i.yU,[l.gk.BraunBlanquet]:i.Dz,[l.gk.Cosine]:i.Zd,[l.gk.Kulczynski]:i.s,[l.gk.McConnaughey]:i.aW,[l.gk.RogotGoldberg]:i.MI,[l.gk.Russel]:i.fX,[l.gk.Sokal]:i.NB,[l.gk.Hamming]:i.UX,[l.gk.Euclidean]:i.WI},d={[l.gd.TanimotoIntArray]:i.FV},m={[l.Yc.Difference]:i.bX},p={[l.gj.CommonItems]:i.Jv},f={[l.Qe.Vector]:{[l.CF.Euclidean]:c[l.CF.Euclidean]},[l.Qe.String]:{[l.W.Levenshtein]:u[l.W.Levenshtein],[l.W.JaroWinkler]:u[l.W.JaroWinkler],[l.W.Manhattan]:u[l.W.Manhattan],[l.W.Onehot]:u[l.W.Onehot]},[l.Qe.BitArray]:{[l.gk.Tanimoto]:h[l.gk.Tanimoto],[l.gk.Dice]:h[l.gk.Dice],[l.gk.Asymmetric]:h[l.gk.Asymmetric],[l.gk.BraunBlanquet]:h[l.gk.BraunBlanquet],[l.gk.Cosine]:h[l.gk.Cosine],[l.gk.Kulczynski]:h[l.gk.Kulczynski],[l.gk.McConnaughey]:h[l.gk.McConnaughey],[l.gk.RogotGoldberg]:h[l.gk.RogotGoldberg],[l.gk.Russel]:h[l.gk.Russel],[l.gk.Sokal]:h[l.gk.Sokal]},[l.Qe.MacroMolecule]:{[a.U.HAMMING]:a.o[a.U.HAMMING],[a.U.LEVENSHTEIN]:a.o[a.U.LEVENSHTEIN],[a.U.NEEDLEMANN_WUNSCH]:a.o[a.U.NEEDLEMANN_WUNSCH],[a.U.MONOMER_CHEMICAL_DISTANCE]:a.o[a.U.MONOMER_CHEMICAL_DISTANCE]},[l.Qe.Number]:{[l.Yc.Difference]:m[l.Yc.Difference]},[l.Qe.IntArray]:{[l.gd.TanimotoIntArray]:d[l.gd.TanimotoIntArray]},[l.Qe.NumberArray]:{[l.gj.CommonItems]:p[l.gj.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},9657:(e,t,n)=>{"use strict";n.d(t,{Z:()=>s});class s{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,r=s._createBuffer(n);if(t)for(let e=0;e<r.length;e++)r[e]=-1;this._data=r,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,s){if(e<t||e>n)throw new Error(`Argument ${s} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let s=0;s<n;s++)t[s]=e[s]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new s(e._length);n._length=e._length,n._data=s._createBuffer(n._length),n._version=0;const r=e.lengthInInts;for(let s=0;s<r;s++)n._data[s]=e._data[s]&t._data[s];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new s(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new s(e);for(let s=0;s<e;++s)n.setBit(s,t(s));return n._version=0,n}static fromString(e){return s.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new s(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new s(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let r=0,i=0;for(;t-i>=4;)n._data[r++]=255&e[i]|(255&e[i+1])<<8|(255&e[i+2])<<16|(255&e[i+3])<<24,i+=4;return t-i==3&&(n._data[r]=(255&e[i+2])<<16),t-i==2&&(n._data[r]|=(255&e[i+1])<<8),t-i==1&&(n._data[r]|=255&e[i]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new s(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,s=this.lengthInInts;for(let e=0;e<s;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,s=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(s)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,s=!0,r=!0){if(n&&r&&this.setAll(!t,!1),r)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(s)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let s=e;s<t;++s)n.push(this.getBit(s));return s.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let s=e;s<t;++s)n.push(this.getBit(s));return n}setRange(e,t,n,s=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const r=Math.min(e,t),i=Math.max(e,t);if(n)for(let e=r;e<=i;e++)this.setTrue(e);else for(let e=r;e<=i;e++)this.setFalse(e);return this.incrementVersion(s),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const s=this._length;this.setLength(this._length+t);for(let n=s-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let s=e;s<e+t;s++)this.setBit(s,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let s=-1;-1!=(s=e.findNext(s,!t));)this.setFast(n++,this.getBit(s));this._length=n,this._version++}return this}getBit(e){return 0!=(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=s._onBitCount[255&e];let n=this._data[t];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=s._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let i=0;for(;i<r-1;i++)for(let t=this._data[i]&e._data[i];0!=t;t>>>=8)n+=s._onBitCount[255&t];let o=this._data[i]&e._data[i];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)n+=s._onBitCount[255&o];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const r=this.lengthInInts;for(let i=Math.floor(e/32);i<r;i++){let r=t?this._data[i]:~this._data[i];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==r)continue;for(let t=0;0!=r;t+=8,r>>>=8){const n=s._firstOnBit[255&r];if(n>=0)return(e=n+32*i+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let r=Math.floor(e/32);r>=0;r--){let e=t?this._data[r]:~this._data[r];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=s._lastOnBit[e>>>24];if(n>=0)return n+32*r+t}}return-1}}s._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),s._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),s._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},279:(e,t,n)=>{"use strict";function s(e,t,n){function s(e,t){let n=null,s=null;for(const r of e){const e=t(r);(null==s||e>s)&&(n=r,s=e)}return n}const r=[(o=e-1,Math.floor(function(e){return Math.random()*e}(o)))],i=new Set;var o;for(let t=0;t<e;++t)r.includes(t)||i.add(t);for(;r.length<t;){const e=s(i.values(),(e=>Math.min.apply(Math,r.map((function(t,s){return n(e,t)})))));null!=e&&(r.push(e),i.delete(e))}return r}n.d(t,{L:()=>s})},2997:(e,t,n)=>{"use strict";n.d(t,{gw:()=>a,zg:()=>o}),n(4469);var s=n(976);n(9133),s.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(s.Column.fromList(s.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,i=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function o(e,t,n,s=0,r="timeout"){return i(this,void 0,void 0,(function*(){return new Promise(((i,o)=>{const a=e.subscribe((e=>{try{t(e),i("OK")}catch(e){o(e)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),o(r)}),s);n()}))}))}function a(e){return i(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(r||(r={})),s.DataFrame.fromColumns([s.Column.fromStrings("col",["val1","val2","val3"])])},850:(e,t,n)=>{"use strict";function s(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function r(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function i(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let s=0;s<e.length;s++)n+=e[s]*t[s];return n}function o(e,t){let n=0;const s=e.length;if(s!==t.length)throw new Error("The dimensionality of the vectors must match");for(let r=0;r<s;++r)n+=Math.pow(e[r]-t[r],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,s=0;for(let r=0;r<t;++r)n+=e[r],s+=Math.pow(e[r],2);const r=n/t,i=1/Math.sqrt(s/t-Math.pow(r,2));for(let n=0;n<t;++n)e[n]=(e[n]-r)*i;return e}n.d(t,{$G:()=>r,Fv:()=>a,MA:()=>i,dP:()=>o,hu:()=>s})},3351:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1581),r=n(3487),i=n(7023),o=n(4815),a=n(4181),l=n(2141),c="errorMessage",u=new s.Name("emUsed"),h={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,m=/\$\{([^}]+)\}/g,p=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:c,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=t;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(e,t){return r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,s._`${e}.instancePath === ${w}`,s._`${e}.keyword in ${t}`,s._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,s._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(e,t){const s=[];for(const n in e){const e=t[n];d.test(e)&&s.push([n,x(e)])}return n.object(...s)}function S(e){return d.test(e)?new i._Code(i.safeStringify(e).replace(m,((e,t)=>`" + JSON.stringify(${o.getData(t,b)}) + "`)).replace(p,"")):s.stringify(e)}function x(e){return s._`function(){return ${S(e)}}`}n.if(s._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[i,o]=function(e){let t,n;for(const s in e){if("properties"===s||"items"===s)continue;const r=e[s];if("object"==typeof r){t||(t={});const e=t[s]={};for(const t in r)e[t]=[]}else n||(n={}),n[s]=[]}return[t,n]}(v);o&&function(r){const i=n.const("emErrors",s.stringify(r)),o=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(e=>n.if(C(e,i),(()=>n.code(s._`${i}[${e}.keyword].push(${e})`).assign(s._`${e}.${u}`,!0)))));const{singleError:c}=e;if(c){const e=n.let("message",s._`""`),r=n.let("paramsErrors",s._`[]`);h((t=>{n.if(e,(()=>n.code(s._`${e} += ${"string"==typeof c?c:";"}`))),n.code(s._`${e} += ${d(t)}`),n.assign(r,s._`${r}.concat(${i}[${t}])`)})),a.reportError(t,{message:e,params:s._`{errors: ${r}}`})}else h((e=>a.reportError(t,{message:d(e),params:s._`{errors: ${i}[${e}]}`})));function h(e){n.forIn("key",i,(t=>n.if(s._`${i}[${t}].length`,(()=>e(t)))))}function d(e){return s._`${e} in ${o} ? ${o}[${e}]() : ${y}[${e}]`}}(o),i&&function(e){const r=n.const("emErrors",s.stringify(e)),i=[];for(const t in e)i.push([t,A(e[t],g[t])]);const o=n.const("templates",n.object(...i)),c=n.scopeValue("obj",{ref:h,code:s.stringify(h)}),d=n.let("emPropParams"),m=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(e=>n.if(C(e,r),(()=>{n.assign(d,s._`${c}[${e}.keyword]`),n.assign(m,s._`${r}[${e}.keyword][${e}.params[${d}]]`),n.if(m,(()=>n.code(s._`${m}.push(${e})`).assign(s._`${e}.${u}`,!0)))})))),n.forIn("key",r,(e=>n.forIn("keyProp",s._`${r}[${e}]`,(i=>{n.assign(m,s._`${r}[${e}][${i}]`),n.if(s._`${m}.length`,(()=>{const r=n.const("tmpl",s._`${o}[${e}] && ${o}[${e}][${i}]`);a.reportError(t,{message:s._`${r} ? ${r}() : ${y}[${e}][${i}]`,params:s._`{errors: ${m}}`})}))}))))}(i),function(e){const{props:i,items:o}=e;if(!i&&!o)return;const h=s._`typeof ${f} == "object"`,d=s._`Array.isArray(${f})`,m=n.let("emErrors");let p,b;const v=n.let("templates");function C(e,t){n.assign(m,s.stringify(e)),n.assign(v,A(e,t))}i&&o?(p=n.let("emChildKwd"),n.if(h),n.if(d,(()=>{C(o,g.items),n.assign(p,s.str`items`)}),(()=>{C(i,g.properties),n.assign(p,s.str`properties`)})),b=s._`[${p}]`):o?(n.if(d),C(o,g.items),b=s._`.items`):i&&(n.if(r.and(h,r.not(d))),C(i,g.properties),b=s._`.properties`),n.forOf("err",l.default.vErrors,(e=>function(e,t,i){n.if(r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,s._`${e}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:s._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),o=n.const("emMatches",s._`${r}.exec(${e}.instancePath.slice(${w}.length))`),a=n.const("emChild",s._`${o} && ${o}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(s._`${a} !== undefined && ${a} in ${t}`,(()=>i(a)))}))}(e,m,(t=>n.code(s._`${m}[${t}].push(${e})`).assign(s._`${e}.${u}`,!0))))),n.forIn("key",m,(e=>n.if(s._`${m}[${e}].length`,(()=>{a.reportError(t,{message:s._`${e} in ${v} ? ${v}[${e}]() : ${y}${b}[${e}]`,params:s._`{errors: ${m}[${e}]}`}),n.assign(s._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,s._`${w} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(v))}const i="string"==typeof v?v:v._;i&&function(e){const i=n.const("emErrs",s._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(function(e){return r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,r.or(s._`${e}.instancePath === ${w}`,r.and(s._`${e}.instancePath.indexOf(${w}) === 0`,s._`${e}.instancePath[${w}.length] === "/"`)),s._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,s._`${e}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(s._`${i}.push(${e})`).assign(s._`${e}.${u}`,!0))))),n.if(s._`${i}.length`,(()=>a.reportError(t,{message:S(e),params:s._`{errors: ${i}}`})))}(i),e.keepErrors||function(){const e=n.const("emErrs",s._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(s._`!${t}.${u}`,(()=>n.code(s._`${e}.push(${t})`))))),n.assign(l.default.vErrors,e).assign(l.default.errors,s._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},5128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;const s=n(7159),r=n(7299),i=n(1240),o=n(4087),a="https://json-schema.org/draft/2020-12/schema";class l extends s.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(i.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(o.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}e.exports=t=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var c=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var u=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var h=n(7426);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var d=n(6646);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},1581:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;const s=n(7159),r=n(3924),i=n(1240),o=n(98),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends s.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(i.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(o,a):o;this.addMetaSchema(e,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}e.exports=t=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var u=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var h=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var d=n(7426);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var m=n(6646);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return m.default}})},7023:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class s extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=s;class r extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof s&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function i(e,...t){const n=[e[0]];let s=0;for(;s<t.length;)l(n,t[s]),n.push(e[++s]);return new r(n)}t._Code=r,t.nil=new r(""),t._=i;const o=new r("+");function a(e,...t){const n=[u(e[0])];let s=0;for(;s<t.length;)n.push(o),l(n,t[s]),n.push(o,u(e[++s]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===o){const n=c(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new r(n)}function l(e,t){var n;t instanceof r?e.push(...t._items):t instanceof s?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function c(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof s||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof s?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=l,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new r(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new r(`.${e}`):i`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new r(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new r(e.toString())}},3487:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const s=n(7023),r=n(8490);var i=n(7023);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return i._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return i.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return i.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return i.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return i.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return i.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return i.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return i.Name}});var o=n(8490);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return o.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return o.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return o.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return o.varKinds}}),t.operators={GT:new s._Code(">"),GTE:new s._Code(">="),LT:new s._Code("<"),LTE:new s._Code("<="),EQ:new s._Code("==="),NEQ:new s._Code("!=="),NOT:new s._Code("!"),OR:new s._Code("||"),AND:new s._Code("&&"),ADD:new s._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class l extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?r.varKinds.var:this.varKind,s=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${s};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=N(this.rhs,e,t)),this}get names(){return this.rhs instanceof s._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof s.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=N(this.rhs,e,t),this}get names(){return $(this.lhs instanceof s.Name?{}:{...this.lhs.names},this.rhs)}}class u extends c{constructor(e,t,n,s){super(e,n,s),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class m extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class p extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=N(this.code,e,t),this}get names(){return this.code instanceof s._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let s=n.length;for(;s--;){const r=n[s];r.optimizeNames(e,t)||(L(e,r.names),n.splice(s,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>M(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new b(e):e}return t?!1===e?t instanceof v?t:t.nodes:this.nodes.length?this:new v(P(e),t instanceof v?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=N(this.condition,e,t),this}get names(){const e=super.names;return $(e,this.condition),this.else&&M(e,this.else.names),e}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=N(this.iteration,e,t),this}get names(){return M(super.names,this.iteration.names)}}class A extends w{constructor(e,t,n,s){super(),this.varKind=e,this.name=t,this.from=n,this.to=s}render(e){const t=e.es5?r.varKinds.var:this.varKind,{name:n,from:s,to:i}=this;return`for(${t} ${n}=${s}; ${n}<${i}; ${n}++)`+super.render(e)}get names(){const e=$(super.names,this.from);return $(e,this.to)}}class S extends w{constructor(e,t,n,s){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=s}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=N(this.iterable,e,t),this}get names(){return M(super.names,this.iterable.names)}}class x extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}x.kind="func";class E extends f{render(e){return"return "+super.render(e)}}E.kind="return";class T extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,s;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(s=this.finally)||void 0===s||s.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&M(e,this.catch.names),this.finally&&M(e,this.finally.names),e}}class I extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}I.kind="catch";class _ extends g{render(e){return"finally"+super.render(e)}}function M(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function $(e,t){return t instanceof s._CodeOrName?M(e,t.names):e}function N(e,t,n){return e instanceof s.Name?i(e):(r=e)instanceof s._Code&&r._items.some((e=>e instanceof s.Name&&1===t[e.str]&&void 0!==n[e.str]))?new s._Code(e._items.reduce(((e,t)=>(t instanceof s.Name&&(t=i(t)),t instanceof s._Code?e.push(...t._items):e.push(t),e)),[])):e;var r;function i(e){const s=n[e.str];return void 0===s||1!==t[e.str]?e:(delete t[e.str],s)}}function L(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function P(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:s._`!${D(e)}`}_.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new r.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,s){const r=this._scope.toName(t);return void 0!==n&&s&&(this._constants[r.str]=n),this._leafNode(new l(e,r,n)),r}const(e,t,n){return this._def(r.varKinds.const,e,t,n)}let(e,t,n){return this._def(r.varKinds.let,e,t,n)}var(e,t,n){return this._def(r.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new c(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==s.nil&&this._leafNode(new p(e)),this}object(...e){const t=["{"];for(const[n,r]of e)t.length>1&&t.push(","),t.push(n),(n!==r||this.opts.es5)&&(t.push(":"),(0,s.addCodeArg)(t,r));return t.push("}"),new s._Code(t)}if(e,t,n){if(this._blockNode(new v(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new v(e))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new C(e),t)}forRange(e,t,n,s,i=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const o=this._scope.toName(e);return this._for(new A(i,o,t,n),(()=>s(o)))}forOf(e,t,n,i=r.varKinds.const){const o=this._scope.toName(e);if(this.opts.es5){const e=t instanceof s.Name?t:this.var("_arr",t);return this.forRange("_i",0,s._`${e}.length`,(t=>{this.var(o,s._`${e}[${t}]`),n(o)}))}return this._for(new S("of",i,o,t),(()=>n(o)))}forIn(e,t,n,i=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,s._`Object.keys(${t})`,n);const o=this._scope.toName(e);return this._for(new S("in",i,o,t),(()=>n(o)))}endFor(){return this._endBlockNode(w)}label(e){return this._leafNode(new h(e))}break(e){return this._leafNode(new d(e))}return(e){const t=new E;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const s=new T;if(this._blockNode(s),this.code(e),t){const e=this.name("e");this._currNode=s.catch=new I(e),t(e)}return n&&(this._currNode=s.finally=new _,this.code(n)),this._endBlockNode(I,_)}throw(e){return this._leafNode(new m(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=s.nil,n,r){return this._blockNode(new x(e,t,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=P;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===s.nil?n:n===s.nil?t:s._`${D(t)} ${e} ${D(n)}`}function D(e){return e instanceof s.Name?e:s._`(${e})`}t.or=function(...e){return e.reduce(O)}},8490:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const s=n(7023);class r extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var i;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(i=t.UsedValueState||(t.UsedValueState={})),t.varKinds={const:new s.Name("const"),let:new s.Name("let"),var:new s.Name("var")};class o{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof s.Name?e:this.name(e)}name(e){return new s.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=o;class a extends s.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=s._`.${new s.Name(t)}[${n}]`}}t.ValueScopeName=a;const l=s._`\n`;t.ValueScope=class extends o{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?l:s.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const s=this.toName(e),{prefix:r}=s,i=null!==(n=t.key)&&void 0!==n?n:t.ref;let o=this._values[r];if(o){const e=o.get(i);if(e)return e}else o=this._values[r]=new Map;o.set(i,s);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=t.ref,s.setValue(t,{property:r,itemIndex:l}),s}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return s._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,o={},a){let l=s.nil;for(const c in e){const u=e[c];if(!u)continue;const h=o[c]=o[c]||new Map;u.forEach((e=>{if(h.has(e))return;h.set(e,i.Started);let o=n(e);if(o){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;l=s._`${l}${n} ${e} = ${o};${this.opts._n}`}else{if(!(o=null==a?void 0:a(e)))throw new r(e);l=s._`${l}${o}${this.opts._n}`}h.set(e,i.Completed)}))}return l}}},4181:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const s=n(3487),r=n(6776),i=n(2141);function o(e,t){const n=e.const("err",t);e.if(s._`${i.default.vErrors} === null`,(()=>e.assign(i.default.vErrors,s._`[${n}]`)),s._`${i.default.vErrors}.push(${n})`),e.code(s._`${i.default.errors}++`)}function a(e,t){const{gen:n,validateName:r,schemaEnv:i}=e;i.$async?n.throw(s._`new ${e.ValidationError}(${t})`):(n.assign(s._`${r}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>s.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?s.str`"${e}" keyword must be ${t} ($data)`:s.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,r,i){const{it:l}=e,{gen:u,compositeRule:h,allErrors:d}=l,m=c(e,n,r);(null!=i?i:h||d)?o(u,m):a(l,s._`[${m}]`)},t.reportExtraError=function(e,n=t.keywordError,s){const{it:r}=e,{gen:l,compositeRule:u,allErrors:h}=r;o(l,c(e,n,s)),u||h||a(r,i.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(i.default.errors,t),e.if(s._`${i.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(s._`${i.default.vErrors}.length`,t)),(()=>e.assign(i.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:r,errsCount:o,it:a}){if(void 0===o)throw new Error("ajv implementation error");const l=e.name("err");e.forRange("i",o,i.default.errors,(o=>{e.const(l,s._`${i.default.vErrors}[${o}]`),e.if(s._`${l}.instancePath === undefined`,(()=>e.assign(s._`${l}.instancePath`,(0,s.strConcat)(i.default.instancePath,a.errorPath)))),e.assign(s._`${l}.schemaPath`,s.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(s._`${l}.schema`,n),e.assign(s._`${l}.data`,r))}))};const l={keyword:new s.Name("keyword"),schemaPath:new s.Name("schemaPath"),params:new s.Name("params"),propertyName:new s.Name("propertyName"),message:new s.Name("message"),schema:new s.Name("schema"),parentSchema:new s.Name("parentSchema")};function c(e,t,n){const{createErrors:r}=e.it;return!1===r?s._`{}`:function(e,t,n={}){const{gen:r,it:o}=e,a=[u(o,n),h(e,n)];return function(e,{params:t,message:n},r){const{keyword:o,data:a,schemaValue:c,it:u}=e,{opts:h,propertyName:d,topSchemaRef:m,schemaPath:p}=u;r.push([l.keyword,o],[l.params,"function"==typeof t?t(e):t||s._`{}`]),h.messages&&r.push([l.message,"function"==typeof n?n(e):n]),h.verbose&&r.push([l.schema,c],[l.parentSchema,s._`${m}${p}`],[i.default.data,a]),d&&r.push([l.propertyName,d])}(e,t,a),r.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?s.str`${e}${(0,r.getErrorPath)(t,r.Type.Str)}`:e;return[i.default.instancePath,(0,s.strConcat)(i.default.instancePath,n)]}function h({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:i}){let o=i?t:s.str`${t}/${e}`;return n&&(o=s.str`${o}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,o]}},5173:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const s=n(3487),r=n(7426),i=n(2141),o=n(2531),a=n(6776),l=n(4815);class c{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,o.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=d.call(this,e);if(t)return t;const n=(0,o.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:u}=this.opts,h=new s.CodeGen(this.scope,{es5:a,lines:c,ownProperties:u});let m;e.$async&&(m=h.scopeValue("Error",{ref:r.default,code:s._`require("ajv/dist/runtime/validation_error").default`}));const p=h.scopeName("validate");e.validateName=p;const f={gen:h,allErrors:this.opts.allErrors,data:i.default.data,parentData:i.default.parentData,parentDataProperty:i.default.parentDataProperty,dataNames:[i.default.data],dataPathArr:[s.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:h.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,s.stringify)(e.schema)}:{ref:e.schema}),validateName:p,ValidationError:m,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:s.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:s._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,l.validateFunctionCode)(f),h.optimize(this.opts.code.optimize);const t=h.toString();g=`${h.scopeRefs(i.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${i.default.self}`,`${i.default.scope}`,g)(this,this.scope.get());if(this.scope.value(p,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:p,validateCode:t,scopeValues:h._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof s.Name?void 0:e,items:t instanceof s.Name?void 0:t,dynamicProps:e instanceof s.Name,dynamicItems:t instanceof s.Name},n.source&&(n.source.evaluated=(0,s.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function h(e){return(0,o.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function d(e){for(const s of this._compilations)if(n=e,(t=s).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return s;var t,n}function m(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||p.call(this,e,t)}function p(e,t){const n=this.opts.uriResolver.parse(t),s=(0,o._getFullPath)(this.opts.uriResolver,n);let r=(0,o.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&s===r)return g.call(this,n,e);const i=(0,o.normalizeId)(s),a=this.refs[i]||this.schemas[i];if("string"==typeof a){const t=p.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),i===(0,o.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,s=t[n];return s&&(r=(0,o.resolveUrl)(this.opts.uriResolver,r,s)),new c({schema:t,schemaId:n,root:e,baseId:r})}return g.call(this,n,a)}}t.SchemaEnv=c,t.compileSchema=u,t.resolveRef=function(e,t,n){var s;n=(0,o.resolveUrl)(this.opts.uriResolver,t,n);const r=e.refs[n];if(r)return r;let i=m.call(this,e,n);if(void 0===i){const r=null===(s=e.localRefs)||void 0===s?void 0:s[n],{schemaId:o}=this.opts;r&&(i=new c({schema:r,schemaId:o,root:e,baseId:t}))}return void 0!==i?e.refs[n]=h.call(this,i):void 0},t.getCompilingSchema=d,t.resolveSchema=p;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:s}){var r;if("/"!==(null===(r=e.fragment)||void 0===r?void 0:r[0]))return;for(const s of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(s)];if(void 0===e)return;const r="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(s)&&r&&(t=(0,o.resolveUrl)(this.opts.uriResolver,t,r))}let i;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,o.resolveUrl)(this.opts.uriResolver,t,n.$ref);i=p.call(this,s,e)}const{schemaId:l}=this.opts;return i=i||new c({schema:n,schemaId:l,root:s,baseId:t}),i.schema!==i.root.schema?i:void 0}},2141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={data:new s.Name("data"),valCxt:new s.Name("valCxt"),instancePath:new s.Name("instancePath"),parentData:new s.Name("parentData"),parentDataProperty:new s.Name("parentDataProperty"),rootData:new s.Name("rootData"),dynamicAnchors:new s.Name("dynamicAnchors"),vErrors:new s.Name("vErrors"),errors:new s.Name("errors"),this:new s.Name("this"),self:new s.Name("self"),scope:new s.Name("scope"),json:new s.Name("json"),jsonPos:new s.Name("jsonPos"),jsonLen:new s.Name("jsonLen"),jsonPart:new s.Name("jsonPart")};t.default=r},6646:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(2531);class r extends Error{constructor(e,t,n,r){super(r||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,s.resolveUrl)(e,t,n),this.missingSchema=(0,s.normalizeId)((0,s.getFullPath)(e,this.missingRef))}}t.default=r},2531:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const s=n(6776),r=n(4063),i=n(9461),o=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!l(e):!!t&&c(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!o.has(n)&&("object"==typeof e[n]&&(0,s.eachItem)(e[n],(e=>t+=c(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=m(t));const s=e.parse(t);return h(e,s)}function h(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=h;const d=/#\/?$/;function m(e){return e?e.replace(d,""):""}t.normalizeId=m,t.resolveUrl=function(e,t,n){return n=m(n),e.resolve(t,n)};const p=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:s}=this.opts,o=m(e[n]||t),a={"":o},l=u(s,o,!1),c={},h=new Set;return i(e,{allKeys:!0},((e,t,s,r)=>{if(void 0===r)return;const i=l+t;let o=a[r];function u(t){const n=this.opts.uriResolver.resolve;if(t=m(o?n(o,t):t),h.has(t))throw f(t);h.add(t);let s=this.refs[t];return"string"==typeof s&&(s=this.refs[s]),"object"==typeof s?d(e,s.schema,t):t!==m(i)&&("#"===t[0]?(d(e,c[t],t),c[t]=e):this.refs[t]=i),t}function g(e){if("string"==typeof e){if(!p.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(o=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=o})),c;function d(e,t,n){if(void 0!==t&&!r(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},3141:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},6776:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const s=n(3487),r=n(7023);function i(e,t=e.schema){const{opts:n,self:s}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const r=s.RULES.keywords;for(const n in t)r[n]||p(e,`unknown keyword: "${n}"`)}function o(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function l(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:r}){return(i,o,a,l)=>{const c=void 0===a?o:a instanceof s.Name?(o instanceof s.Name?e(i,o,a):t(i,o,a),a):o instanceof s.Name?(t(i,a,o),o):n(o,a);return l!==s.Name||c instanceof s.Name?c:r(i,c)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",s._`{}`);return void 0!==t&&h(e,n,t),n}function h(e,t,n){Object.keys(n).forEach((n=>e.assign(s._`${t}${(0,s.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(i(e,t),!o(t,e.self.RULES.all))},t.checkUnknownRules=i,t.schemaHasRules=o,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,r,i){if(!i){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return s._`${n}`}return s._`${e}${t}${(0,s.getProperty)(r)}`},t.unescapeFragment=function(e){return l(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=l,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:c({mergeNames:(e,t,n)=>e.if(s._`${n} !== true && ${t} !== undefined`,(()=>{e.if(s._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,s._`${n} || {}`).code(s._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(s._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,s._`${n} || {}`),h(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:c({mergeNames:(e,t,n)=>e.if(s._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,s._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(s._`${n} !== true`,(()=>e.assign(n,!0===t||s._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=h;const d={};var m;function p(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:d[t.code]||(d[t.code]=new r._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(m=t.Type||(t.Type={})),t.getErrorPath=function(e,t,n){if(e instanceof s.Name){const r=t===m.Num;return n?r?s._`"[" + ${e} + "]"`:s._`"['" + ${e} + "']"`:r?s._`"/" + ${e}`:s._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,s.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=p},8876:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>s(e,t)))}function s(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},s){const r=t.RULES.types[s];return r&&!0!==r&&n(e,r)},t.shouldUseGroup=n,t.shouldUseRule=s},5667:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const s=n(4181),r=n(3487),i=n(2141),o={message:"boolean schema is false"};function a(e,t){const{gen:n,data:r}=e,i={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,s.reportError)(i,o,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:s}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(i.default.data):(t.assign(r._`${s}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:s}=e;!1===s?(n.var(t,!1),a(e)):n.var(t,!0)}},453:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const s=n(3141),r=n(8876),i=n(4181),o=n(3487),a=n(6776);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(s.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l=t.DataType||(t.DataType={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:s,opts:i}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,i.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,r.schemaHasRulesForType)(e,t[0]));if(c){const r=d(t,s,i.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(e,t,n){const{gen:s,data:r,opts:i}=e,a=s.let("dataType",o._`typeof ${r}`),l=s.let("coerced",o._`undefined`);"array"===i.coerceTypes&&s.if(o._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>s.assign(r,o._`${r}[0]`).assign(a,o._`typeof ${r}`).if(d(t,r,i.strictNumbers),(()=>s.assign(l,r))))),s.if(o._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===i.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void s.elseIf(o._`${a} == "number" || ${a} == "boolean"`).assign(l,o._`"" + ${r}`).elseIf(o._`${r} === null`).assign(l,o._`""`);case"number":return void s.elseIf(o._`${a} == "boolean" || ${r} === null
2
+ var bio;(()=>{var e={2012:(e,t,n)=>{"use strict";n.d(t,{f:()=>r});var s=n(9976);class r extends s.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,r)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,r)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new r({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(e){const t=e in r.aaSynonyms?r.aaSynonyms[e]:e;return super.get(t)}}r.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class i{static getPalette(e="grok"){switch(e){case"grok":return r.GrokGroups;case"lesk":return r.Lesk;default:throw new Error(`ChemPalette: scheme \`${e}\` does not exist`)}}static getInnerOuter(e){let t=0,n="",s="";for(const r of e)"("==r?t++:")"==r?t--:t?n+=r:s+=r;return isNaN(parseInt(n))?[s,n]:[s,""]}static getColorAAPivot(e="",t="grok"){const n=this.getPalette(t);let[s,r]=this.getInnerOuter(e);if(s=s.length>6?`${s.slice(0,3)}...`:s,r=r.length>6?`${r.slice(0,3)}...`:r,1==e.length||"("==e[1]){const t=e[0]?.toUpperCase();return t in n?[n.get(t),t,r,1]:[this.undefinedColor,s,r,1]}if("d"==e[0]&&e[1]in n&&(2==e.length||"("==e[2])){const t=e[1]?.toUpperCase();return t in n?[n.get(t),t,r,2]:[this.undefinedColor,s,r,2]}if(e.substring(0,3)in this.AAFullNames&&(3==e.length||"("==e[3])){const t=this.AAFullNames[e.substring(0,3)];return t in n?[n.get(t),t,r,3]:[this.undefinedColor,s,r,3]}if(e[0]?.toLowerCase()==e[0]&&e.substring(1,3)in this.AAFullNames&&(4==e.length||"("==e[4])){const t=this.AAFullNames[e.substring(1,3)];return t in n?[n.get(t),t,r,4]:[this.undefinedColor,s,r,4]}return[this.undefinedColor,s,r,0]}}i.SemType="Aminoacids",i.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",i.undefinedColor="rgb(100,100,100)",i.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},i.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},i.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},i.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},6584:(e,t,n)=>{"use strict";n.d(t,{BX:()=>i,nW:()=>a,tW:()=>l});var s=n(4469);const r="Libraries",i="System:AppData/Bio/monomer-libraries/";let o=Promise.resolve();async function a(){let e;return o=o.then((async()=>{const t=await s.dapi.userDataStorage.getValue(r,"Settings",!0);e=t?JSON.parse(t):{exclude:[],explicit:[]},e.exclude=e.exclude instanceof Array?e.exclude:[],e.explicit=e.explicit instanceof Array?e.explicit:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(e,void 0,2)}`)})),await o,e}async function l(e){o=o.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(e,void 0,2)}`),await s.dapi.userDataStorage.postValue(r,"Settings",JSON.stringify(e),!0)})),await o}},7228:(e,t,n)=>{"use strict";n.d(t,{GR:()=>m,JN:()=>u,Qx:()=>h,Xk:()=>c});var s=n(976),r=n(4469),i=n(5697),o=n(1047),a=n(6286),l=(n(8607),n(8457));function c(e){const t=[];for(let n=0;n<e.rowCount;n++){const s={};Object.keys(o.K4).forEach((t=>{if("symbol"===t){const r=e.get(o.K4[t],n);s[t]="."===r?e.get(o.At,n):r}else if("rgroups"===t){const r=e.get(o.K4[t],n).split("\n"),i=[];r.forEach((e=>{const t={},n=e.substring(e.lastIndexOf("]")+1),s=e.match(/\[R(\d+)\]/)[1];t.capGroupSmiles="H"===n?`[*:${s}][H]`:`O[*:${s}]`,t.alternateId="H"===n?`R${s}-H`:`R${s}-OH`,t.capGroupName="H"===n?"H":"OH",t.label=`R${s}`,i.push(t)})),s[t]=i}else o.K4[t]&&(s[t]=e.get(o.K4[t],n))})),s.author??(s.author=""),s.id??(s.id=0),s.smiles??(s.smiles=""),s.monomerType??(s.monomerType="Backbone"),s.createDate??(s.createDate=null),t.push(s)}return t}async function u(){const e=s.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===e.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await e[0].prepare().call()).getOutputParamValue()}async function h(e,t){e instanceof s.Column&&(e=(0,l.O)(e).columns.toList());const n=(await u()).getBioLib(),i=new Array(e.length),o=e[0].length,c=new Float32Array(o);for(let l=0;l<e.length;++l){const u=t.getCanonical(l),h=n.getMonomer("PEPTIDE",u)?.smiles??"",d=e[l],m=d.getRawData(),p=d.categories,f=p.indexOf("");if(i[l]={categories:p,data:m,emptyIndex:f},void 0===u)continue;const g=s.Column.fromStrings("smiles",p.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??""))),y=(s.DataFrame.fromColumns([g]),(await r.chem.getSimilarities(g,h)).getRawData());for(let e=0;e<o;++e){const t=m[e];c[e]+=u!==a.G2&&t!==f?y[t]:u===a.G2&&t===f?1:0}}for(let n=0;n<c.length;++n){let r=c[n]/t.length;for(let o=0;o<e.length;++o){const e=i[o];if(o>=t.length&&e.data[n]!==e.emptyIndex||e.data[n]===e.emptyIndex&&o<t.length){r=s.FLOAT_NULL;break}}c[n]=r}return s.Column.fromFloat32Array("Similarity",c)}async function d(e){const t=(await u()).getBioLib(),n=[],i={},o=e.map((e=>t.getMonomer("PEPTIDE",e)?.smiles??"")),a=s.Column.fromStrings("smiles",o);for(let t=0;t<o.length;++t){i[e[t]]=t;const s=o[t],l=""===s?new Array(o.length).fill(0):(await r.chem.getSimilarities(a,s)).getRawData();l[t]=1,n[t]=Array.from(l)}return{scoringMatrix:n,alphabetIndexes:i}}async function m(e,t="Morgan"){const n=(await u()).getBioLib(),r=new Array(e.length).fill(0).map((()=>new Array(e.length).fill(0))),o={},a=e.map((e=>n.getMonomer("PEPTIDE",e)?.smiles??"")),l=s.Func.find({package:"Chem",name:"getFingerprints"})[0];if(!l)return console.warn('Function "Chem:getFingerprints" is not found in chem package. falling back to Morgan fingerprints'),await d(e);const c=s.Column.fromStrings("smiles",a),h=(s.DataFrame.fromColumns([c]),(await l.apply({col:c,fingerprintType:t}))?.entries);if(!h)return console.warn(`${t} Fingerprints could not be calculated for monomers from chem package.\n falling back to Morgan fingerprints`),await d(e);for(let t=0;t<h.length;++t)if(r[t][t]=1,o[e[t]]=t,h[t])for(let e=t+1;e<h.length;++e)h[e]&&(r[t][e]=r[e][t]=(0,i.Z3)(h[t],h[e]));return{scoringMatrix:r,alphabetIndexes:o}}},8601:(e,t,n)=>{"use strict";n.d(t,{i0:()=>d});var s=n(4469),r=n(976),i=n(6414),o=n.n(i),a=n(1821),l=n(8607);const c={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG=",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var u=n(1047);function h(e){return Math.round(c.PRECISION_FACTOR*e)/c.PRECISION_FACTOR}async function d(e,t,i){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(t.semType!==r.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${r.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${t.semType}'`]};let h=t;const d=l.g.forColumn(t);d.isHelm()&&(h=d.convert(a.r2.SEPARATOR,"."),h.name=t.name);const p=l.g.forColumn(h).alphabet;let f;if(p===a.fb.PT||p===a.fb.UN)f="PEPTIDE";else{if(p!==a.fb.RNA&&p!==a.fb.DNA)return{col:null,warnings:[`Unexpected column's '${h.name}' alphabet '${p}'.`]};f="RNA"}const g=function(e){const t=e.length,n=new Array(t),r=l.g.forColumn(e);let i=!1;for(let e=0;e<t;++e){const t=r.getSplitted(e);i||(i=0===t.length),n[e]=o()(t.canonicals).filter((e=>!r.isGap(e))).map((e=>e)).toArray()}return i&&s.shell.warning(`Some values in the "${e.name}" column are empty`),n}(h),y=await async function(e,t,n,r){const i=function(e,t,n){const s=new Map;for(const r of e.getMonomerSymbolsByType(t)){const i=e.getMonomer(t,r);if("RNA"===t&&("Branch"===i.monomerType||n===a.fb.DNA&&i.symbol===c.DEOXYRIBOSE||n===a.fb.RNA&&i.symbol===c.RIBOSE||i.symbol===c.PHOSPHATE)||"PEPTIDE"===t&&"Branch"!==i.monomerType){const e={};u.rx.forEach((t=>{e[t]=i[t]})),s.set(i.symbol,e)}}return s}(t,n,r),o=new Map,l=await s.functions.call("Chem:getRdKitModule"),h={value:null};if("RNA"===n){const e=r===a.fb.RNA?[c.RIBOSE,c.PHOSPHATE]:[c.DEOXYRIBOSE,c.PHOSPHATE];for(const t of e)m(o,t,i,l,n,h)}for(let t=0;t<e.length;++t){const s=e[t];for(const e of s)if(""!==e)try{m(o,e,i,l,n,h)}catch(t){const n=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${e}', error:\n${n}\n${s}`),new Error(`Can't get monomer '${e}' from library: ${n}`)}}return o}(g,i,f,p),b=h.length,{molfileList:v,molfileWarningList:w}=await async function(e,t,s,r,i){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(n.p+n.u(286),n.b)))),l=i/o;let c=[],u=[];const h=new Array(o);for(let n=0;n<o;n++){const c=Math.floor(n*l),u=n===o-1?i:Math.floor((n+1)*l);a[n].postMessage({monomerSequencesArray:e,monomersDict:t,alphabet:s,polymerType:r,start:c,end:u}),h[n]=new Promise((e=>{a[n].onmessage=({data:{molfileList:t,molfileWarningList:n}})=>{e({molfileList:t,molfileWarningList:n})}}))}return(await Promise.all(h)).forEach((e=>{c=c.concat(...e.molfileList),u=u.concat(...e.molfileWarningList)})),setTimeout((()=>{a.forEach((e=>{e.terminate()}))}),0),{molfileList:c,molfileWarningList:u}}(g,y,p,f,b);if(w.length>.05*b)throw new Error("Too many errors getting molfiles.");const C=`molfile(${h.name})`,A=e.columns.getUnusedName(C),S=r.Column.fromStrings(A,v);return S.semType=r.SEMTYPE.MOLECULE,S.setTag(r.TAGS.UNITS,r.UNITS.Molecule.MOLBLOCK),{col:S,warnings:w}}function m(e,t,n,s,r,i){if(!e.has(t)){const o=function(e,t,n,s,r){if(t.has(e)){const o=t.get(e),a=function(e){const t=[];for(const n of e){let e=n.capGroupSmiles;e||(e=n.capGroupSMILES),e=e.replace(/(\[|\]|\*|:|\d)/g,""),t.push(e)}return t}(o.rgroups),l=(i=o.molfile).includes("V3000")?function(e){const t=new Map,n=/M V30 (\d+) R#.+RGROUPS=\((\d+) (\d+)\).*/gm;let s;for(;null!==(s=n.exec(e));)s.index===n.lastIndex&&n.lastIndex++,t.set(parseInt(s[1]),parseInt(s[3]));return t}(i):function(e){const t=new Map;let n=e.indexOf(c.V2K_A_LINE,0),s=n;for(;-1!==n;){s=e.indexOf("\n",n);const r=parseInt(e.substring(n,s).replace(/^A\s+/,""));n=e.indexOf("R",s),s=e.indexOf("\n",n);const i=parseInt(e.substring(n,s).replace(/^R/,""));t.set(r,i),n=e.indexOf(c.V2K_A_LINE,s)}for(n=e.indexOf(c.V2K_RGP_LINE,0),s=e.indexOf("\n",n);-1!==n;){n+=c.V2K_RGP_SHIFT,s=e.indexOf("\n",n);const r=e.substring(n,s).replaceAll(/\s+/g," ").split(" ").map((e=>parseInt(e))).slice(1);for(let e=0;e<r.length;e+=2){if(t.has(r[e])&&t.get(r[e])!==r[e+1])throw new Error(`r-group index ${r[e]} has already been added with a different value`);t.set(r[e],r[e+1])}n=e.indexOf(c.V2K_RGP_LINE,s)}return t}(i),u=o.molfile.includes("V3000")?o.molfile:function(e,t){const n=t.get_mol(e),s=n.get_v3Kmolblock();return n.delete(),s}(function(e){let t=e.indexOf(c.V2K_A_LINE,0);-1===t&&(t=e.indexOf(c.V2K_RGP_LINE));const n=e.indexOf(c.V3K_END,t);return e.substring(0,t)+e.substring(n)}(o.molfile),n),d=function(e){let t=(e=e.replaceAll("\r","")).indexOf(c.V3K_BEGIN_COUNTS_LINE)+c.V3K_COUNTS_SHIFT,n=e.indexOf(" ",t+1);const s=parseInt(e.substring(t,n));return t=n+1,n=e.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(e.substring(t,n))}}(u),m=function(e,t){const n=new Array(t),s=new Float32Array(t),r=new Float32Array(t),i=new Array(t);let o=e.indexOf(c.V3K_BEGIN_ATOM_BLOCK);o=e.indexOf("\n",o);let a=o;for(let l=0;l<t;l++){o=e.indexOf(c.V3K_BEGIN_DATA_LINE,o)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",o),o=a+1,a=e.indexOf(" ",o),n[l]=e.substring(o,a);const t=new Array(2);for(let n=0;n<2;++n)o=a+1,a=e.indexOf(" ",o),t[n]=parseFloat(e.substring(o,a));s[l]=t[0],r[l]=t[1],o=a,a=e.indexOf("\n",o)+1,i[l]=e.slice(o,a),o=a}return{atomTypes:n,x:s,y:r,kwargs:i}}(u,d.atomCount),g=function(e,t){const n=new Uint32Array(t),s=new Array(t),r=new Map,i=new Map;let o=e.indexOf(c.V3K_BEGIN_BOND_BLOCK);o=e.indexOf("\n",o);let a=o;for(let l=0;l<t;++l){const t=new Array(3);o=e.indexOf(c.V3K_BEGIN_DATA_LINE,a)+c.V3K_IDX_SHIFT,a=e.indexOf(" ",o);for(let n=0;n<3;++n)o=a+1,a=Math.min(e.indexOf("\n",o),e.indexOf(" ",o)),t[n]=parseInt(e.slice(o,a));n[l]=t[0],s[l]=t.slice(1);const u=e.indexOf("\n",o);let h=e.slice(a,u),d=h.indexOf(c.V3K_BOND_CONFIG);if(-1!==d){d=h.indexOf("=",d)+1;let e=h.indexOf(" ",d);-1===e&&(e=h.length);const t=parseInt(h.slice(d,e));r.set(l,t);const n=c.V3K_BOND_CONFIG+t.toString();h=h.replace(n,"")}h||i.set(l,h)}return{bondTypes:n,atomPairs:s,bondConfiguration:r,kwargs:i}}(u,d.bondCount),b=function(e,t,n,s){const r={backboneShift:null,branchShift:null,terminalNodes:[],rNodes:[]};return function(e,t,n){for(const[s,r]of n)e.atomTypes[s-1]=t[r-1]}(e,n,s),function(e,t){t.rNodes=Array.from(e.keys());for(let n=0;n<t.rNodes.length;n++)for(const s of[1,2])if(e.get(t.rNodes[n])===s){const e=t.rNodes[s-1];t.rNodes[s-1]=t.rNodes[n],t.rNodes[n]=e}}(s,r),p(t,r),r}(m,g,a,l),S=function(e){let t=[],n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(");for(;-1!==n;){n+=28;const s=e.indexOf(")",n);t=t.concat(e.substring(n,s).split(" ").slice(1).map((e=>parseInt(e)))),n=s,n=e.indexOf("M V30 MDLV30/STEABS ATOMS=(",n)}return t}(u),x={atoms:m,bonds:g,meta:b,stereoAtoms:S};return"PEPTIDE"===s?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,s=e.atoms.x,r=e.atoms.y;A(e,-s[t],-r[t]);const i=v(s[n],r[n]);w(e.atoms,-i),s[e.meta.rNodes[1]-1]<0&&function(e){C(e,!1)}(e);const o=function(e){const t=function(e){const t=new Map;for(const n of e.bonds.atomPairs)for(let e=0;e<2;e++){const s=n[e],r=n[(e+1)%2];t.has(s)?t.get(s)?.push(r):t.set(s,new Array(1).fill(r))}return t}(e);let n=0;const s=e.atoms.atomTypes.length;let r=0;for(;0===n;){const i=t.get(e.meta.terminalNodes[1])[r];if(e.atoms.atomTypes[i-1]===c.OXYGEN&&i!==e.meta.rNodes[1]&&(n=i),r++,r>s)throw new Error(`Search for double-bonded Oxygen in ${e} has exceeded the limit of ${s}`)}return n}(e);!function(e,t){e.atoms.y[e.meta.rNodes[1]-1]<0&&e.atoms.y[t-1]<0&&(function(e){C(e,!0)}(e),w(e.atoms,-function(e,t){return v(e,t)+Math.PI/2}(e.atoms.x[e.meta.terminalNodes[1]-1],e.atoms.y[e.meta.terminalNodes[1]-1])))}(e,o),function(e,t){const n=e.atoms.x;n[e.meta.rNodes[1]-1]>n[t-1]&&function(e,t,n){const s=t-1,r=n-1,i=e.atoms.x,o=e.atoms.y,a=i[s],l=o[s];i[s]=i[r],o[s]=o[r],i[r]=a,o[r]=l}(e,t,e.meta.rNodes[1])}(e,o)}(x):e===c.RIBOSE||e===c.DEOXYRIBOSE?function(e,t){const n=e.atoms.x,s=e.atoms.y;let r=e.meta.terminalNodes[0]-1;const i=e.meta.rNodes[1]-1;A(e,-n[r],-s[r]);const o=v(n[i],s[i]);w(e.atoms,3*Math.PI/2-o),t.value=function(e){const t=e.atoms.x,n=e.atoms.y,s=e.meta.rNodes[2]-1,r=e.meta.terminalNodes[2]-1,i=t[s]-t[r],o=n[s]-n[r];return Math.atan(o/i)+Math.PI/2}(e),r=e.meta.terminalNodes[0]-1,A(e,-n[r],-s[r])}(x,r):e===c.PHOSPHATE?function(e){const t=e.meta.terminalNodes[0]-1,n=e.meta.rNodes[0]-1,s=e.atoms.x,r=e.atoms.y;A(e,-s[t],-r[t]);const i=v(s[n],r[n]);w(e.atoms,Math.PI/2-i)}(x):function(e,t){const n=e.atoms.x,s=e.atoms.y,r=e.meta.terminalNodes[0]-1,i=e.meta.rNodes[0]-1;A(e,-n[r],-s[r]);const o=v(n[i],s[i]),a=t.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");w(e.atoms,Math.PI-o+a);const l=function(e,t){return h(Math.sqrt((e.x-t.x)**2+(e.y-t.y)**2))}({x:n[e.meta.rNodes[0]-1],y:s[e.meta.rNodes[0]-1]},{x:n[e.meta.terminalNodes[0]-1],y:s[e.meta.terminalNodes[0]-1]});if(1!=l)for(let e=0;e<n.length;++e)n[e]=h(n[e]/l),s[e]=h(s[e]/l)}(x,r),function(e,t,n){"PEPTIDE"===e?(f(t,e),y(t,t.meta.rNodes[1])):n===c.RIBOSE||n===c.DEOXYRIBOSE?(y(t,t.meta.rNodes[1]),t.meta.rNodes[1]=t.meta.terminalNodes[1],p(t.bonds,t.meta),f(t,e),y(t,t.meta.rNodes[1]),y(t,t.meta.rNodes[0]),y(t,t.meta.rNodes[2])):n===c.PHOSPHATE&&(t.meta.terminalNodes[0]=t.meta.rNodes[0],A(t,-t.atoms.x[t.meta.terminalNodes[0]-1],-t.atoms.y[t.meta.terminalNodes[0]-1]),f(t,e),y(t,t.meta.rNodes[1]))}(s,x,e),function(e){let t=0;for(;t<e.atoms.atomTypes.length;)e.atoms.atomTypes[t]===c.HYDROGEN&&(y(e,t+1),--t),++t}(x),x}var i;return null}(t,n,s,r,i);if(!o)throw new Error(`Monomer with symbol '${t}' is absent the monomer library`);e.set(t,o)}}function p(e,t){const n=t.rNodes;t.terminalNodes=new Array(n.length).fill(0);const s=t.terminalNodes,r=e.atomPairs;let i=0,o=0;for(;i<r.length&&o<s.length;){for(let e=0;e<s.length;++e)for(let t=0;t<2;++t)r[i][t]===n[e]&&(s[e]=r[i][(t+1)%2],n.length,++o);++i}}function f(e,t){e.meta.rNodes.length>1&&(e.meta.backboneShift=g(e,e.meta.rNodes[1]-1,e.meta.terminalNodes[0]-1)),"RNA"===t&&e.meta.rNodes.length>2&&(e.meta.branchShift=g(e,e.meta.rNodes[2]-1,e.meta.terminalNodes[0]-1))}function g(e,t,n){return[h(e.atoms.x[t]-e.atoms.x[n]),h(e.atoms.y[t]-e.atoms.y[n])]}function y(e,t){if(void 0!==t){const n=t-1,s=e.atoms,r=e.bonds,i=e.meta;s.atomTypes.splice(n,1),s.x=b(Float32Array,s.x,n,1),s.y=b(Float32Array,s.y,n,1),s.kwargs.splice(n,1);for(let e=0;e<i.terminalNodes.length;++e)i.terminalNodes[e]>t?--i.terminalNodes[e]:i.terminalNodes[e]===t&&(i.terminalNodes[e]=-1);for(let e=0;e<i.rNodes.length;++e)i.rNodes[e]>t?--i.rNodes[e]:i.rNodes[e]===t&&(i.rNodes[e]=-1);let o=0;for(;o<r.atomPairs.length;){const e=r.atomPairs[o][0],n=r.atomPairs[o][1];e===t||n===t?(r.atomPairs.splice(o,1),r.bondTypes=b(Uint32Array,r.bondTypes,o,1),r.bondConfiguration.has(o)&&r.bondConfiguration.delete(o),r.kwargs.has(o)&&r.kwargs.delete(o),--o):(r.atomPairs[o][0]=e>t?e-1:e,r.atomPairs[o][1]=n>t?n-1:n),++o}let a=Array.from(r.bondConfiguration.keys());a.forEach((e=>{if(r.bondConfiguration.has(e)&&e>n){const t=r.bondConfiguration.get(e);r.bondConfiguration.delete(e),r.bondConfiguration.set(e-1,t)}})),a=Array.from(r.kwargs.keys()),a.forEach((e=>{if(r.kwargs.has(e)&&e>n){const t=r.kwargs.get(e);r.kwargs.delete(e),r.kwargs.set(e-1,t)}}))}}function b(e,t,n,s){const r=new e(t.length-s);let i=0,o=0;for(;i<t.length;)i===n&&(i+=s),r[o]=t[i],++o,++i;return r}function v(e,t){let n;if(0===e)n=t>0?0:Math.PI;else if(0===t)n=e>0?-Math.PI/2:Math.PI/2;else{const s=t/e,r=Math.atan(s);n=e<0?Math.PI/2+r:-Math.PI/2+r}return n}function w(e,t){if(0!==t){const n=e.x,s=e.y,r=Math.cos(t),i=Math.sin(t);for(let e=0;e<n.length;++e){const t=n[e];n[e]=h(t*r-s[e]*i),s[e]=h(t*i+s[e]*r)}}}function C(e,t){if(t){const t=e.atoms.y;for(let e=0;e<t.length;e++)t[e]=-t[e]}else{const t=e.atoms.x;for(let e=0;e<t.length;e++)t[e]=-t[e]}const n=e.bonds.bondConfiguration;for(const[e,t]of n){const s=1===t?3:1;n.set(e,s)}}function A(e,t,n){const s=e.atoms.x,r=e.atoms.y;for(let e=0;e<s.length;++e)s[e]=h(s[e]+t),void 0!==n&&(r[e]=h(r[e]+n))}},6137:(e,t,n)=>{"use strict";n.d(t,{J:()=>r});var s=n(9976);class r extends s.B{static get Chromatogram(){return void 0===this.chromatogram&&(this.chromatogram=new r({A:"green",C:"blue",G:"black",T:"red",U:"red",others:"gray"})),this.chromatogram}}class i{}i.SemType="Nucleotides",i.SemTypeMultipleAlignment="NucleotidesMultipleAlignment",i.Names={A:"Adenine",C:"Cytosine",G:"Guanine",T:"Thymine",U:"Uracil"}},9976:(e,t,n)=>{"use strict";n.d(t,{B:()=>s});class s{static makePalette(e,t=!1,n=s){const r={};return e.forEach((e=>{const n=e[0],s=e[1];n.forEach(((e,n)=>{r[e]=this.colourPalette[s][t?0:n]}))})),new n(r)}constructor(e){this._palette=e}get(e){return this._palette[e]}}s.undefinedColor="rgb(100,100,100)",s.colourPalette={orange:["rgb(255,187,120)","rgb(245,167,100)","rgb(235,137,70)","rgb(205, 111, 71)"],all_green:["rgb(44,160,44)","rgb(74,160,74)","rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)","rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],all_blue:["rgb(31,119,180)","rgb(23,190,207)","rgb(122, 102, 189)","rgb(158,218,229)","rgb(141, 124, 217)","rgb(31, 120, 150)"],magenta:["rgb(162,106,192)","rgb(197,165,224)","rgb(208,113,218)"],red:["rgb(214,39,40)","rgb(255,152,150)"],st_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(31,119,180)"],dark_blue:["rgb(31,119,180)","rgb(31, 120, 150)"],light_blue:["rgb(23,190,207)","rgb(158,218,229)","rgb(108, 218, 229)","rgb(23,190,227)"],lilac_blue:["rgb(124,102,211)","rgb(149,134,217)","rgb(97, 81, 150)"],dark_green:["rgb(23,103,57)","rgb(30,110,96)","rgb(60,131,95)","rgb(24,110,79)"],green:["rgb(44,160,44)","rgb(74,160,74)"],light_green:["rgb(152,223,138)","rgb(182, 223, 138)","rgb(152, 193, 138)"],st_green:["rgb(44,160,44)","rgb(152,223,138)","rgb(39, 174, 96)","rgb(74,160,74)"],pink:["rgb(247,182,210)"],brown:["rgb(140,86,75)","rgb(102, 62, 54)"],gray:["rgb(127,127,127)","rgb(199,199,199)","rgb(196,156,148)","rgb(222, 222, 180)"],yellow:["rgb(188,189,34)"],white:["rgb(230,230,230)"]}},7331:(e,t,n)=>{"use strict";n.d(t,{UE:()=>c});var s=n(976),r=n(9976);class i{static hashCode(e){let t=0;if(0===e.length)return t;for(let n=0;n<e.length;n++)t=(t<<5)-t+e.charCodeAt(n),t|=0;return t}}class o{}class a extends o{get(e){return"#666666"}}class l extends o{static buildPalette(){return[].concat(...Object.values(r.B.colourPalette))}get(e){const t=i.hashCode(e)%l.palette.length;return function(e){if(null==e)return"rgb(100,100,100)";const t=s.Color.fromHtml(e),n=s.Color.g(t),r=s.Color.r(t),i=s.Color.b(t),o=Math.sqrt(Math.pow(0-r,2)+Math.pow(0-n,2)+Math.pow(0-i,2));return o>210?`rgb(${r/o*210},${n/o*210},${i/o*210})`:s.Color.toRgb(t)}(l.palette[t])}}l.palette=l.buildPalette();class c extends r.B{static get Gray(){return void 0===this.gray&&(this.gray=new a),this.gray}static get Color(){return void 0===this.color&&(this.color=new l),this.color}}},9713:(e,t,n)=>{"use strict";n.d(t,{N:()=>o,b:()=>a});var s=n(4469),r=n(701),i=n(2997);function o(e){let t=null,n=null;try{n=e.dart?e.gridColumn:null,t=n?n.temp:null}catch{[n,t]=[null,null]}const s=e.cell.column;if(t=t??s.temp,!t)throw new Error("Grid cell renderer back store (GridColumn or Column) not found.");return[n,s,t]}class a{constructor(e,t,n){this.gridCol=e,this.tableCol=t,this.logger=n,this.subs=[],this.destroyed=!1,this.viewerId=++a.viewerCounter,this.errors=[],this._onRendered=new r.Subject,this.reset(),this.tableCol&&this.tableCol.dataFrame&&this.subs.push(this.tableCol.dataFrame.onDataChanged.subscribe((()=>{try{this.reset()}catch(e){this.logger.error(e)}}))),this.tableCol&&this.subs.push(s.events.onTableRemoved.subscribe((e=>{try{const t=e.args.dataFrame;this.tableCol?.dataFrame.id!==t.id||this.destroyed||this.destroy()}catch(e){this.logger.error(e)}}))),this.gridCol&&this.subs.push(s.events.onViewRemoving.subscribe((e=>{try{const t=e.args.view;this.gridCol?.dart&&this.gridCol.grid&&this.gridCol?.grid?.dart&&this.gridCol?.grid?.view?.id===t.id&&!this.destroyed&&this.destroy()}catch(e){this.logger.error(e)}})))}toLog(){return`${this.constructor.name}<${this.viewerId}>`}destroy(){for(const e of this.subs)e.unsubscribe();this.destroyed=!0}invalidateGrid(){this.gridCol&&this.gridCol.dart&&this.gridCol.grid?.invalidate()}get onRendered(){return this._onRendered}invalidate(e){this.invalidateGrid()}async awaitRendered(e=1e4,t=`${e} timeout`){const n=`${this.toLog()}.awaitRendered()`;if(this.logger.debug(`${n}, start, testEvent before`),await(0,i.zg)(this._onRendered,(()=>{}),(()=>{this.invalidate()}),e,`${n}, ${t}`),this.errors.length>0){const e=this.errors[0];throw this.errors=[],e}this.logger.debug(`${n}, end`)}}a.viewerCounter=-1},9611:(e,t,n)=>{"use strict";n.d(t,{A:()=>c});var s=n(976),r=n(6414),i=n.n(r),o=n(8607),a=n(9713),l=n(7228);class c extends a.b{constructor(e,t,n,r,i){super(e,t,n),this.monomerLengthLimit=r,this.propsProvider=i,this.colWidth=0,this._monomerLengthList=null,this.separatorWidth=5,this._processedMaxVisibleSeqLength=0,this._monomerLengthMap={},this._monomerStructureMap={},this.props=this.propsProvider(),this._processedRows=s.BitSet.create(this.tableCol.length),this.gridCol&&this.subs.push(this.gridCol.grid.onAfterDrawContent.subscribe((()=>{this._onRendered.next()}))),(0,l.JN)().then((e=>{if(this.destroyed)return;const t=e.getBioLib();this.subs.push(t.onChanged.subscribe((()=>{this.reset(),this.gridCol?.grid?.invalidate()})))}))}reset(){this.propsProvider&&(this.props=this.propsProvider()),this._processedRows=s.BitSet.create(this.tableCol.length),this._monomerLengthList=null,this._monomerLengthMap={},this._monomerStructureMap={}}getCellMonomerLengths(e,t){this.colWidth<t&&(this.colWidth=t,this.reset());const n=this.props.seqHandler.isMsa()?this.getCellMonomerLengthsForSeqMsa():this.getCellMonomerLengthsForSeq(e),s=new Array(n.length+1);s[0]=5;for(let e=1;e<s.length;e++)s[e]=s[e-1]+n[e-1];return[n,s]}getCellMonomerLengthsForSeq(e){this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(this.tableCol.length).fill(null));const t=this.props.separatorWidth+1*this.props.monomerCharWidth,n=Math.ceil(this.colWidth/t),s=o.g.forColumn(this.tableCol).getSplitted(e).originals,r=Math.min(n,s.length);let i=this._monomerLengthList[e];if(null===i||i.length<r){i=this._monomerLengthList[e]=new Array(s.length);let t=0;for(let e=0;e<r;++e){const n=s[e],r=this.props.monomerToShort(n,this.monomerLengthLimit),o=(this.props.seqHandler.isSeparator()?this.separatorWidth:this.props.separatorWidth)+r.length*this.props.monomerCharWidth;if(i[e]=o,t+=o,t>this.colWidth)break}}return i}getCellMonomerLengthsForSeqMsa(){var e;this.toLog(),null===this._monomerLengthList&&(this._monomerLengthList=new Array(1).fill(null)),(e=this._monomerLengthList)[0]??(e[0]=new Array(0));const t=this._monomerLengthList[0],{startIdx:n,endIdx:s}=(()=>{try{const e=this.gridCol&&this.gridCol.dart?this.gridCol.grid:null;return e&&e.dart?{startIdx:Math.max(Math.floor((e?.vertScroll.min??0)-10),0),endIdx:Math.min(Math.ceil((e?.vertScroll.max??0)+10),this.tableCol.length)}:{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}catch(e){return{startIdx:0,endIdx:Math.min(this.tableCol.length,10)}}})(),r=this.props.separatorWidth+1*this.props.monomerCharWidth,i=Math.ceil(this.colWidth/r);for(let e=n;e<s;e++){if(this._processedRows.get(e)&&i<=this._processedMaxVisibleSeqLength)continue;const n=o.g.forColumn(this.tableCol).getSplitted(e,i).originals,s=Math.min(i,n.length);s>t.length&&t.push(...new Array(s-t.length).fill(r));let a=0;for(let e=0;e<s;++e){const s=n[e],r=this.props.monomerToShort(s,this.monomerLengthLimit),i=this.props.separatorWidth+r.length*this.props.monomerCharWidth;if(t[e]=Math.max(t[e]??0,i),a+=i,a>=this.colWidth)break}this._processedMaxVisibleSeqLength=Math.max(this._processedMaxVisibleSeqLength,i)}return t}getPosition(e,t,n){const[s,r]=this.getCellMonomerLengths(e,n),a=o.g.forColumn(this.tableCol);return 0===i()(a.getSplitted(e).originals).toArray().length?null:function(e,t){let n,s=100,r=0,i=e.length-1;for(;r<=i;){if(n=Math.floor((i+r)/2),e[n]<=t&&t<e[n+1])return n;if(t<e[n]?i=n-1:r=n+1,--s<=0)throw new Error(`Get position for pointer x = ${t} searching has not converged on ${JSON.stringify(e)}. `)}return null}(r,t)}setMonomerLengthLimit(e){this.monomerLengthLimit=e,this.reset()}setSeparatorWidth(e){this.props.separatorWidth=e,this.reset()}isMsa(){return this.props.seqHandler.isMsa()}}},1047:(e,t,n)=>{"use strict";n.d(t,{$3:()=>o,At:()=>r,K4:()=>i,pU:()=>a,rx:()=>s});const s=["symbol","molfile","rgroups","name"],r="MonomerName",i={monomerType:null,smiles:null,name:"Name",author:null,molfile:"molecule",naturalAnalog:"MonomerNaturalAnalogCode",rgroups:"MonomerCaps",createDate:null,id:null,polymerType:"MonomerType",symbol:"MonomerName"},o="p",a=new RegExp(`[rd]\\((\\w)\\)${o}?`,"g")},7945:(e,t,n)=>{"use strict";function s(e){return"string"==typeof e||e instanceof String?e:"StateError"===e.constructor.name?e.message:"StateError"===e.constructor.name&&"$thrownJsError"in e?s(e.$thrownJsError):e instanceof Error?e.message:e.toString()}function r(e){return e instanceof Error?e.stack:"StateError"===e.constructor.name&&"$thrownJsError"in e?r(e.$thrownJsError):void 0}function i(e){return[s(e),r(e)]}n.d(t,{yf:()=>i})},5226:(e,t,n)=>{"use strict";n.d(t,{i:()=>o});var s=n(976),r=n(8607),i=n(1821);class o{get descriptionsArray(){return this._descriptionsArray}get sequencesArray(){return this._sequencesArray}parseMacromolecule(e,t){return this._fileContent.slice(e,t).split(/\s/).join("")}parseColumns(){const e=/^>(.*)$/gm;let t,n=0;for(;t=e.exec(this._fileContent);){const s=this._fileContent.substring(t.index+1,e.lastIndex);this._descriptionsArray.push(s),0!==n&&this._sequencesArray.push(this.parseMacromolecule(n,t.index)),n=e.lastIndex+1}this._sequencesArray.push(this.parseMacromolecule(n,-1))}importFasta(){const e=s.Column.fromStrings("description",this.descriptionsArray),t=s.Column.fromStrings("sequence",this.sequencesArray);return t.semType=s.SEMTYPE.MACROMOLECULE,t.setTag(s.TAGS.UNITS,i.r2.FASTA),r.g.forColumn(t),[s.DataFrame.fromColumns([e,t])]}constructor(e){this._descriptionsArray=[],this._sequencesArray=[],this._fileContent=e,this.parseColumns()}}},706:(e,t,n)=>{"use strict";n.d(t,{io:()=>c,wl:()=>u});var s=n(976),r=n(6414),i=n.n(r),o=n(8447),a=n(8607),l=n(8260);function c(e=10**5){const t="meI/hHis/Aca/N//dE/Thr_PO3H2/Aca/D-Tyr_Et/Tyr_ab-dehydroMe".repeat(Math.ceil(e/10)).slice(0,-1),n=s.Column.fromList(s.COLUMN_TYPE.STRING,"MSA",new Array(100).fill(t));n.semType=s.SEMTYPE.MACROMOLECULE,n.setTag(s.TAGS.UNITS,o.r2.SEPARATOR),n.setTag(o.DX.separator,"/"),n.setTag(o.DX.alphabet,o.fb.UN),n.setTag(o.DX.alphabetIsMultichar,"true");const r=[];return r.push(n),r.push(s.Column.fromList(s.COLUMN_TYPE.FLOAT,"Activity",new Array(100).fill(7.30751))),r}function u(e=o.r2.SEPARATOR,t=o.fb.PT,n=(e===o.r2.SEPARATOR?"-":void 0),r=undefined,c="seq",u=100,h=10**6){const d=t===o.fb.UN?r?.getMonomerSymbolsByType("PEPTIDE")??[]:Array.from((0,o.gM)(t)),m=d.length,p=s.Column.fromType(s.COLUMN_TYPE.STRING,c,u);p.semType=s.SEMTYPE.MACROMOLECULE,p.setTag(s.TAGS.UNITS,e),p.setTag(o.DX.alphabet,t),e==o.r2.SEPARATOR&&p.setTag(o.DX.separator,n);const f=a.g.forColumn(p);for(let t=0;t<u;t++){const n=i().count(0).take(h).map((e=>d[Math.floor(Math.random()*m)])).toArray(),s=f.joiner(new l.wx(n,a.lh[e]));p.set(t,s)}return p}},1821:(e,t,n)=>{"use strict";n.d(t,{BM:()=>l,CI:()=>a,DX:()=>i,XS:()=>u,fb:()=>r,r2:()=>s,se:()=>c});var s,r,i,o=n(6286);!function(e){e.FASTA="fasta",e.SEPARATOR="separator",e.HELM="helm"}(s||(s={})),function(e){e.DNA="DNA",e.RNA="RNA",e.PT="PT",e.UN="UN"}(r||(r={})),function(e){e.aligned="aligned",e.alphabet="alphabet",e.alphabetSize=".alphabetSize",e.alphabetIsMultichar=".alphabetIsMultichar",e.separator="separator",e.isHelmCompatible=".isHelmCompatible",e.positionNames=".positionNames",e.positionLabels=".positionLabels",e.regions=".regions"}(i||(i={}));const a=", ",l=/(?:\[([A-Za-z0-9_\-,()]+)\])|([A-Za-z\-])/g,c=new class{constructor(){this.fasta={peptide:new Set(["G","L","Y","S","E","Q","D","N","F","A","K","R","H","C","V","P","W","I","M","T"]),dna:new Set(["A","C","G","T"]),rna:new Set(["A","C","G","U"])}}},u=[new o.LA(r.PT,c.fasta.peptide,.5),new o.LA(r.DNA,c.fasta.dna,.55),new o.LA(r.RNA,c.fasta.rna,.55)]},8447:(e,t,n)=>{"use strict";n.d(t,{Ar:()=>r.Ar,CI:()=>s.CI,DX:()=>s.DX,GU:()=>r.GU,XS:()=>s.XS,dQ:()=>r.dQ,fb:()=>s.fb,gM:()=>r.gM,gP:()=>r.gP,kB:()=>r.kB,py:()=>r.py,r2:()=>s.r2,up:()=>r.up});var s=n(1821),r=n(8260)},6286:(e,t,n)=>{"use strict";n.d(t,{G2:()=>s,LA:()=>r,dJ:()=>i});const s="";class r{constructor(e,t,n){this.name=e,this.alphabet=t,this.cutoff=n}}class i extends r{constructor(e,t,n){super(e.name,e.alphabet,e.cutoff),this.freq=t,this.similarity=n}}},8260:(e,t,n)=>{"use strict";n.d(t,{wx:()=>p,w4:()=>T,gM:()=>E,py:()=>I,vU:()=>A,Ar:()=>b,GU:()=>x,dQ:()=>_,up:()=>M,kB:()=>g,FJ:()=>y,gP:()=>C});var s=n(976),r=n(6414),i=n.n(r),o=n(6286),a=n(1821),l=n(8607);class c extends Float32Array{}var u=n(850),h=n(2012),d=n(6137),m=n(7331);class p{get length(){return this.mList.length}get canonicals(){return this.mList}get originals(){return this.mList}isGap(e){return this.getOriginal(e)===this.gapOriginalMonomer}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.mList[e]}constructor(e,t){this.mList=e,this.gapOriginalMonomer=t}}class f{get length(){return this.seqS.length}get canonicals(){return this.seqS}get originals(){return this.seqS}isGap(e){return this.getOriginal(e)===l.lh[a.r2.FASTA]}getCanonical(e){if(this.length<=e)throw new Error("Index out of bounds");return this.isGap(e)?o.G2:this.seqS[e]}getOriginal(e){if(this.length<=e)throw new Error("Index out of bounds");return this.seqS[e]}constructor(e){this.seqS=e}}const g=e=>{const t=i()(e.toString().matchAll(a.BM)).map((e=>e[2]??e[1])).toArray();return new p(t,l.lh[a.r2.FASTA])},y=e=>e?new f(e):new p([],l.lh[a.r2.FASTA]);function b(e,t=undefined){return n=>{if(n){let s;const r=new RegExp(String.raw`"-"|'-'|[^${e}]+`,"g");if(void 0!==t){r.lastIndex=0,s=new Array(Math.ceil(t));let e=null,i=0;for(;null!==(e=r.exec(n))&&i<t;)s[i++]=e[0].replace('"-"',"").replace("'-'","");s.splice(i)}else s=n.replaceAll('"-"',"").replaceAll("'-'","").split(e,t);return new p(s,l.lh[a.r2.SEPARATOR])}return new p([],l.lh[a.r2.SEPARATOR])}}const v=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,w=/\[([^\[\]]+)]/g,C=e=>{v.lastIndex=0;const t=v.exec(e.toString()),n=t?t[2]:null,s=n?n.split("."):[];return new p(s.map((e=>{w.lastIndex=0;const t=w.exec(e);return t&&t.length>=2?t[1]:e})),l.lh[a.r2.HELM])};function A(e,t,n=undefined){if(e.toLowerCase().startsWith(a.r2.FASTA))return g;if(e.toLowerCase().startsWith(a.r2.SEPARATOR))return b(t,n);if(e.toLowerCase().startsWith(a.r2.HELM))return C;throw new Error(`Unexpected units ${e} .`)}const S=/([^\W_]+)/g;function x(e,t){if(e.length<=t)return e;const n=e.match(S),s=e.length>t||(n?.length??0)>1,r=n?.[0]??" ";return s?r.substring(0,t-1)+"…":r}function E(e){switch(e){case a.fb.DNA:return a.se.fasta.dna;case a.fb.RNA:return a.se.fasta.rna;case a.fb.PT:return a.se.fasta.peptide;default:throw new Error(`Unsupported alphabet '${e}'.`)}}function T(e,t,n="-"){const s=t.map((t=>{const s=function(e,t,n="-"){const s=new Set([...new Set(Object.keys(e)),...t]);s.delete(n);const r=[],i=[];for(const n of s)r.push(n in e?e[n]:0),i.push(t.has(n)?1:0);const o=new c(r),a=new c(i);return(0,u.MA)(o,a)/((0,u.$G)(o)*(0,u.$G)(a))}(e,t.alphabet,n);return new o.dJ(t,e,s)}));let r;const i=Math.max(...s.map((e=>e.similarity>e.cutoff?e.similarity:-1)));return r=i>0?s.find((e=>e.similarity===i)).name:a.fb.UN,r}function _(e,t=5){let n;if(e.semType==s.SEMTYPE.MACROMOLECULE)n=l.g.forColumn(e).alphabet;else{const s=function(e,t,n){const s=e.categories;return function(e,t){const n={};let s=!0,r=null;for(const i of e)if(null==r?r=i.length:i.length!==r&&(s=!1),i.length>=t)for(const e of i.canonicals)e in n||(n[e]=0),n[e]+=1;return{freq:n,sameLength:s}}(i().enumerate(e.getRawData()).map((([e,t])=>n(s[e]))),t)}(e,t,g);n=T(s.freq,a.XS)}return I(n)}function I(e){switch(e){case a.fb.PT:return h.f.GrokGroups;case a.fb.DNA:case a.fb.RNA:return d.J.Chromatogram;default:return m.UE.Color}}function M(e){const t=e.columns.bySemTypeAll(s.SEMTYPE.MACROMOLECULE);let n=t.find((e=>{const t=e.getTag(s.TAGS.UNITS);return!!t&&-1!==t.indexOf("MSA")}))??null;return!n&&t.length>0&&(n=t[0]),n}},8607:(e,t,n)=>{"use strict";n.d(t,{dm:()=>d,g:()=>p,lh:()=>m});var s=n(976),r=n(6414),i=n.n(r),o=n(8447),a=n(6286),l=n(8260),c=n(708),u=n(7228),h=n(1047);const d=new class{constructor(){this.seqHandler="seq-handler",this.notationProvider="seq-handler.notation-provider"}},m={[o.r2.FASTA]:"-",[o.r2.SEPARATOR]:"",[o.r2.HELM]:"*"};class p{constructor(e){if(this._splitter=null,this.cached=!0,this._splitted=null,this.columnVersion=null,this._stats=null,this._maxLength=null,this._posList=null,this._joiner=void 0,e.type!==s.TYPE.STRING)throw new Error(`Unexpected column type '${e.type}', must be '${s.TYPE.STRING}'.`);this._column=e;const t=this._column.getTag(s.TAGS.UNITS);if(null==t)throw new Error("Units are not specified in column");if(this._units=t,this._notation=this.getNotation(),this._defaultGapOriginal=this.isFasta()?m[o.r2.FASTA]:this.isHelm()?m[o.r2.HELM]:m[o.r2.SEPARATOR],!this.column.tags.has(o.DX.aligned)||!this.column.tags.has(o.DX.alphabet)||!this.column.tags.has(o.DX.alphabetIsMultichar)&&!this.isHelm()&&this.alphabet===o.fb.UN)if(this.isFasta())p.setUnitsToFastaColumn(this);else if(this.isSeparator()){const t=e.getTag(o.DX.separator);p.setUnitsToSeparatorColumn(this,t)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(s.TAGS.UNITS)}'.`);p.setUnitsToHelmColumn(this)}if(!this.column.tags.has(o.DX.alphabetIsMultichar))if(this.isHelm())this.column.setTag(o.DX.alphabetIsMultichar,"true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '${o.DX.alphabetIsMultichar}' is mandatory.`);this.notationProvider=this.column.temp[d.notationProvider]??null,this.columnVersion=this.column.version}static setUnitsToFastaColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.getTag(s.TAGS.UNITS)!==o.r2.FASTA)throw new Error(`The column of notation '${o.r2.FASTA}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);e.column.setTag(s.TAGS.UNITS,o.r2.FASTA),p.setTags(e)}static setUnitsToSeparatorColumn(e,t){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE||e.column.getTag(s.TAGS.UNITS)!==o.r2.SEPARATOR)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must be '${s.SEMTYPE.MACROMOLECULE}'.`);if(!t)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must have the separator tag.`);e.column.setTag(s.TAGS.UNITS,o.r2.SEPARATOR),e.column.setTag(o.DX.separator,t),p.setTags(e)}static setUnitsToHelmColumn(e){if(e.column.semType!==s.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.r2.HELM}' must be '${s.SEMTYPE.MACROMOLECULE}'`);e.column.setTag(s.TAGS.UNITS,o.r2.HELM),p.setTags(e)}static setTags(e){const t=e.column.getTag(s.TAGS.UNITS);if([o.r2.FASTA,o.r2.SEPARATOR].includes(t)){if(!e.column.getTag(o.DX.alphabet)&&0===Object.keys(e.stats.freq).length)throw new Error("Alphabet is empty and not annotated.");let t=e.column.getTag(o.DX.aligned);null===t&&(t=e.stats.sameLength?"SEQ.MSA":"SEQ",e.column.setTag(o.DX.aligned,t));let n=e.column.getTag(o.DX.alphabet);if(null===n&&(n=(0,l.w4)(e.stats.freq,o.XS),e.column.setTag(o.DX.alphabet,n)),n===o.fb.UN){const t=Object.keys(e.stats.freq).length,n=Object.keys(e.stats.freq).some((e=>e.length>1));e.column.setTag(o.DX.alphabetSize,t.toString()),e.column.setTag(o.DX.alphabetIsMultichar,n?"true":"false")}}}get column(){return this._column}get length(){return this._column.length}get units(){return this._units}get notation(){return this._notation}get defaultGapOriginal(){return this._defaultGapOriginal}get separator(){const e=this.column.getTag(o.DX.separator)??void 0;if(this.notation===o.r2.SEPARATOR&&void 0===e)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return e}get aligned(){const e=this.column.getTag(o.DX.aligned);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return e}get alphabet(){const e=this.column.getTag(o.DX.alphabet);if(!e&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return e}get helmCompatible(){return this.column.getTag(o.DX.isHelmCompatible)}getAlphabetSize(){if(this.notation==o.r2.HELM||this.alphabet==o.fb.UN){const e=this.column.getTag(o.DX.alphabetSize);let t;if(e)t=parseInt(e);else{const e=this.stats;t=Object.keys(e.freq).length}return t}switch(this.alphabet){case o.fb.PT:return 20;case o.fb.DNA:case o.fb.RNA:return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.r2.HELM||this.alphabet===o.fb.UN&&"true"===this.column.getTag(o.DX.alphabetIsMultichar)}getSplitted(e,t){if(this.cached&&void 0===t){this.column.version===this.columnVersion&&null!==this._splitted||(this.columnVersion=this.column.version,this._splitted=new Array(this.column.length));let t=this._splitted[e]?this._splitted[e].deref():void 0;if(!t){const n=this.column.get(e);t=this.splitter(n),this._splitted[e]=new WeakRef(t)}return t}{const n=this.column.get(e);return this.getSplitter(t)(n)}}get stats(){if(null===this._stats){const e={};let t=!0,n=null;const s=this.column.length;for(let r=0;r<s;++r){const s=this.getSplitted(r);null==n?n=s.length:s.length!==n&&(t=!1);for(const t of s.canonicals)t in e||(e[t]=0),e[t]+=1}this._stats={freq:e,sameLength:t}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=0===this.column.length?0:Math.max(...i().count(0).take(this.column.length).map((e=>this.getSplitted(e).length)))),this._maxLength}get posList(){if(null===this._posList){const e=this.column.getTag(o.DX.positionNames);this._posList=e?e.split(o.CI).map((e=>e.trim())):i().count(1).take(this.maxLength).map((e=>e.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.r2.FASTA}isSeparator(){return this.notation===o.r2.SEPARATOR}isHelm(){return this.notation===o.r2.HELM}isRna(){return this.alphabet===o.fb.RNA}isDna(){return this.alphabet===o.fb.DNA}isPeptide(){return this.alphabet===o.fb.PT}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(e){return!e||e===this._defaultGapOriginal}getNotation(){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return o.r2.FASTA;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return o.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(e,t,n,r){const i=this.column,a=e.toLowerCase()+"("+i.name+")",l=n??i.dataFrame.columns.getUnusedName(a),c=s.Column.fromList("string",l,r??new Array(this.column.length).fill(""));if(c.semType=s.SEMTYPE.MACROMOLECULE,c.setTag(s.TAGS.UNITS,e),e===o.r2.SEPARATOR){if(!t)throw new Error(`Notation '${o.r2.SEPARATOR}' requires separator value.`);c.setTag(o.DX.separator,t)}c.setTag(s.TAGS.CELL_RENDERER,e===o.r2.HELM?"helm":"sequence");const u=i.getTag(o.DX.aligned);u&&c.setTag(o.DX.aligned,u);let h=i.getTag(o.DX.alphabet);h||this.notation!==o.r2.HELM||e===o.r2.HELM||(h=o.fb.UN),null!=h&&c.setTag(o.DX.alphabet,h);let d=i.getTag(o.DX.alphabetSize);null!=h&&d&&c.setTag(o.DX.alphabetSize,d);const m=i.getTag(o.DX.alphabetIsMultichar);return null!=h&&void 0!==m&&c.setTag(o.DX.alphabetIsMultichar,m),e==o.r2.HELM&&(d=this.getAlphabetSize().toString(),c.setTag(o.DX.alphabetSize,d)),c}getNewColumnFromList(e,t){return this.getNewColumn(this.notation,this.separator,e,t)}static getNewColumn(e){const t=p.forColumn(e),n=t.notation;return t.getNewColumn(n)}static unitsStringIsValid(e){return e=e.toLowerCase(),[o.r2.FASTA,o.r2.SEPARATOR,o.r2.HELM].some((t=>e.startsWith(t.toLowerCase())))}static getNewColumnFromParams(e,t,n){if(!p.unitsStringIsValid(n))throw new Error("Invalid format of 'units' parameter");const r=s.Column.fromList("string",t,new Array(e).fill(""));return r.semType=s.SEMTYPE.MACROMOLECULE,r.setTag(s.TAGS.UNITS,n),r}getSplitter(e){let t=null;if(t=this.notationProvider?this.notationProvider.splitter:null,t)return t;if(this.units.toLowerCase().startsWith(o.r2.FASTA))return null===this.column.getTag(o.DX.alphabet)||this.getAlphabetIsMultichar()?o.kB:l.FJ;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return(0,o.Ar)(this.separator,e);if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.gP;throw new Error(`Unexpected units ${this.units} .`)}split(e){return this.splitter(e)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return c.U.HAMMING;switch(this.alphabet){case o.fb.DNA:case o.fb.RNA:case o.fb.PT:}return c.U.LEVENSHTEIN}getDistanceFunction(){return c.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(o.DX.isHelmCompatible))return"true"===this.column.getTag(o.DX.isHelmCompatible);const e=(await(0,u.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE"),t=new Set(e),n=((0,o.Ar)(this.separator),new Set),s=this.column.length,r=this.column.getRawData();for(let e=0;e<s;++e){const s=r[e];if(!(s in n)){n.add(s);const r=this.getSplitted(e);for(const e of r.canonicals)if(!t.has(e))return this.column.setTag(o.DX.isHelmCompatible,"false"),!1}}return this.column.setTag(o.DX.isHelmCompatible,"true"),!0}get splitter(){return null===this._splitter&&(this._splitter=this.getSplitter()),this._splitter}toFasta(e){return e===o.r2.FASTA}toSeparator(e){return e===o.r2.SEPARATOR}toHelm(e){return e===o.r2.HELM}convertHelmToFastaSeparator(e,t,n,s){s||(s=this.toFasta(t)?m[o.r2.FASTA]:m[o.r2.SEPARATOR]),n||(n=this.toFasta(t)?"":this.separator);const r=e.startsWith("RNA"),i=this.splitter(e),a=[];for(let e=0;e<i.length;++e){let n=i.getOriginal(e);if(r&&(n=n.replace(h.pU,"")),n===m[o.r2.HELM])a.push(s);else if(this.toFasta(t)&&n.length>1){const e="["+n+"]";a.push(e)}else a.push(n)}return a.join(n)}convert(e,t){const n=this.getJoiner({notation:e,separator:t}),s=this.getNewColumn(e,t);return s.init((e=>{const t=this.getSplitted(e);return n(t)})),s}getRegion(e,t,n){const s=this.getNewColumn(this.notation,this.separator);s.name=n;const r=e??0,i=t??this.maxLength-1,a=this.getJoiner(),c=i-r+1,u=m[this.notation];s.init((e=>{const t=this.getSplitted(e),n=new Array(c);for(let e=0;e<c;++e){const s=r+e;n[e]=s<t.length?t.getOriginal(s):u}return a(new l.wx(n,u))}));const h=e=>{const t=e.split(",").map((e=>e.trim())),n=new Array(c);for(let e=0;e<c;++e){const s=r+e;n[e]=s<t.length?t[s]:"?"}return n.join(o.CI)},d=this.column.getTag(o.DX.positionNames);d&&s.setTag(o.DX.positionNames,h(d));const p=this.column.getTag(o.DX.positionLabels);return p&&s.setTag(o.DX.positionLabels,h(p)),s}get joiner(){return this._joiner||(this._joiner=this.getJoiner()),this._joiner}getJoiner(e){const t=e?e.notation:this.notation,n=e?e.separator:this.separator;let s;const r=this;switch(t){case o.r2.FASTA:s=function(e){return r.joinToFasta(e,r.isHelm())};break;case o.r2.SEPARATOR:if(!n)throw new Error(`Separator is mandatory for notation '${t}'.`);s=function(e){return f(e,n,r.isHelm())};break;case o.r2.HELM:{const e=r.alphabet===o.fb.DNA||r.alphabet===o.fb.RNA,t=r.getHelmWrappers();s=function(n){return g(n,t,e)};break}default:throw new Error(`Unexpected notation '${t}'.`)}return s}getConverter(e,t=undefined){if(e===o.r2.SEPARATOR&&!t)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const n=this;if(e===o.r2.FASTA)return function(e){return n.convertToFasta(e)};if(e===o.r2.HELM)return function(e){return n.convertToHelm(e)};if(e===o.r2.SEPARATOR)return function(e){return n.convertToSeparator(e,t)};throw new Error}static forColumn(e){let t=e.temp[d.seqHandler];return t&&t.columnVersion===e.version||(t=e.temp[d.seqHandler]=new p(e)),t}joinToFasta(e,t){const n=new Array(e.length);for(let s=0;s<e.length;++s){const r=e.getOriginal(s);let i=e.getOriginal(s);t&&(i=i.replace(h.pU,"$1")),r===a.G2?i=m[o.r2.FASTA]:r===h.$3?i="":i.length>1&&(i="["+i+"]"),n[s]=i}return n.join("")}convertToFasta(e){const t=this.splitter,n=this.isHelm()?this.splitterAsHelmNucl(e):t(e);return this.joinToFasta(n,this.isHelm())}convertToSeparator(e,t){return f(this.isHelm()?this.splitterAsHelmNucl(e):this.splitter(e),t,this.isHelm())}convertToHelm(e){const t=this.getHelmWrappers(),n=e.startsWith("DNA")||e.startsWith("RNA");return g(this.splitter(e),t,n)}splitterAsHelmNucl(e){const t=this.splitter(e),n=new Array(t.length),s=e.startsWith("DNA"),r=e.startsWith("RNA");for(let e=0;e<t.length;++e){let i=t.getOriginal(e);(s||r)&&(i=i.replace(h.pU,"$1"),i=i===h.$3?null:i),n[e]=i||null}return new l.wx(n.filter((e=>!!e)),m[o.r2.HELM])}}function f(e,t,n){const s=new Array(e.length);for(let t=0;t<e.length;++t){const r=e.getCanonical(t);let i=e.getOriginal(t);n&&(i=i.replace(h.pU,"$1")),r===a.G2?i=m[o.r2.SEPARATOR]:r===h.$3&&(i=""),s[t]=i}return s.join(t)}function g(e,t,n){const[s,r,i,l]=t,c=new Array(e.length);for(let t=0;t<e.length;++t){const s=e.getCanonical(t);let l=e.getOriginal(t);s===a.G2?l=m[o.r2.HELM]:(n&&(l=l.replace(h.pU,"$1")),l=1===l.length?`${r}${l}${i}`:`${r}[${l}]${i}`),c[t]=l}return`${s}${c.join(".")}${l}`}},8457:(e,t,n)=>{"use strict";n.d(t,{O:()=>i});var s=n(976),r=n(8607);function i(e){const t=e=>{const t=o.columns.addNewString((e+1).toString());return n.push(t),t},n=[],i=e.length,o=s.DataFrame.create(i),a=r.g.forColumn(e);for(let e=0;e<i;++e){const s=a.getSplitted(e);for(let r=0;r<s.length;++r){const i=s.getOriginal(r);((n[r]??null)||t(r)).set(e,i,!1)}}return o}},172:(e,t,n)=>{"use strict";n.d(t,{c:()=>i});var s,r=n(7945);!function(e){e[e.error=0]="error",e[e.warning=1]="warning",e[e.info=2]="info",e[e.debug=3]="debug"}(s||(s={}));class i{constructor(e){this.logger=e,this.promise=Promise.resolve(),this.errors=[],this.syncCounter=0}sync(e,t){const n=++this.syncCounter;this.logger.debug(`${e}, SYNC syncId = ${n}, IN `),this.promise=this.promise.then((async()=>{this.logger.debug(`${e}, SYNC syncId = ${n}, START `),await t(),this.logger.debug(`${e}, SYNC syncId = ${n}, END `)})).catch((t=>{const[s,i]=(0,r.yf)(t);this.logger.error(`${e}, SYNC syncId = ${n}, ERROR:\n${s}`,void 0,i),this.errors.push(t)}))}resetErrors(){const e=this.errors;return this.errors=[],e}}},9298:(e,t,n)=>{"use strict";n.d(t,{Ct:()=>l,DX:()=>s,ES:()=>r,dE:()=>a,iD:()=>o,vS:()=>u,vw:()=>i});var s,r,i,o,a,l,c=n(976);!function(e){e.tooltipWebLogo=".tooltipWebLogo"}(s||(s={})),function(e){e.Entropy="Entropy",e.full="100%"}(r||(r={})),function(e){e.TOP="top",e.MIDDLE="middle",e.BOTTOM="bottom"}(i||(i={})),function(e){e.LEFT="left",e.CENTER="center",e.RIGHT="right"}(o||(o={})),function(e){e.AUTO="auto",e.ON="on",e.OFF="off"}(a||(a={})),function(e){e.Filtered="Filtered",e.Selected="Selected"}(l||(l={}));const u=new class{constructor(){this.sequenceColumnName=null,this.valueAggrType=c.AGG.TOTAL_COUNT,this.valueColumnName="Activity",this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=r.Entropy,this.positionWidth=16,this.verticalAlignment=i.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},7905:(e,t,n)=>{"use strict";e=n.hmd(e);var s,r=(s="undefined"!=typeof document&&document.currentScript?document.currentScript.src:void 0,function(e={}){var t,n,r=void 0!==e?e:{};r.ready=new Promise((function(e,s){t=e,n=s}));var i,o=Object.assign({},r),a="object"==typeof window,l="function"==typeof importScripts,c=("object"==typeof process&&"object"==typeof process.versions&&process.versions.node,"");(a||l)&&(l?c=self.location.href:"undefined"!=typeof document&&document.currentScript&&(c=document.currentScript.src),s&&(c=s),c=0!==c.indexOf("blob:")?c.substr(0,c.replace(/[?#].*/,"").lastIndexOf("/")+1):"",l&&(i=e=>{var t=new XMLHttpRequest;return t.open("GET",e,!1),t.responseType="arraybuffer",t.send(null),new Uint8Array(t.response)})),r.print||console.log.bind(console);var u,h,d=r.printErr||console.warn.bind(console);Object.assign(r,o),o=null,r.arguments&&r.arguments,r.thisProgram&&r.thisProgram,r.quit&&r.quit,r.wasmBinary&&(u=r.wasmBinary),r.noExitRuntime,"object"!=typeof WebAssembly&&x("no native wasm support detected");var m,p,f,g=!1;function y(){var e=h.buffer;r.HEAP8=m=new Int8Array(e),r.HEAP16=new Int16Array(e),r.HEAP32=new Int32Array(e),r.HEAPU8=p=new Uint8Array(e),r.HEAPU16=new Uint16Array(e),r.HEAPU32=f=new Uint32Array(e),r.HEAPF32=new Float32Array(e),r.HEAPF64=new Float64Array(e)}var b=[],v=[],w=[],C=0,A=null,S=null;function x(e){r.onAbort&&r.onAbort(e),d(e="Aborted("+e+")"),g=!0,e+=". Build with -sASSERTIONS for more info.";var t=new WebAssembly.RuntimeError(e);throw n(t),t}var E,T,_="data:application/octet-stream;base64,";function I(e){return e.startsWith(_)}function M(e){try{if(e==E&&u)return new Uint8Array(u);if(i)return i(e);throw"both async and sync fetching of the wasm failed"}catch(e){x(e)}}function N(e,t,n){return function(e){return u||!a&&!l||"function"!=typeof fetch?Promise.resolve().then((function(){return M(e)})):fetch(e,{credentials:"same-origin"}).then((function(t){if(!t.ok)throw"failed to load wasm binary file at '"+e+"'";return t.arrayBuffer()})).catch((function(){return M(e)}))}(e).then((function(e){return WebAssembly.instantiate(e,t)})).then((function(e){return e})).then(n,(function(e){d("failed to asynchronously prepare wasm: "+e),x(e)}))}function $(e){for(;e.length>0;)e.shift()(r)}function L(e){this.excPtr=e,this.ptr=e-24,this.set_type=function(e){f[this.ptr+4>>2]=e},this.get_type=function(){return f[this.ptr+4>>2]},this.set_destructor=function(e){f[this.ptr+8>>2]=e},this.get_destructor=function(){return f[this.ptr+8>>2]},this.set_caught=function(e){e=e?1:0,m[this.ptr+12>>0]=e},this.get_caught=function(){return 0!=m[this.ptr+12>>0]},this.set_rethrown=function(e){e=e?1:0,m[this.ptr+13>>0]=e},this.get_rethrown=function(){return 0!=m[this.ptr+13>>0]},this.init=function(e,t){this.set_adjusted_ptr(0),this.set_type(e),this.set_destructor(t)},this.set_adjusted_ptr=function(e){f[this.ptr+16>>2]=e},this.get_adjusted_ptr=function(){return f[this.ptr+16>>2]},this.get_exception_ptr=function(){if(U(this.get_type()))return f[this.excPtr>>2];var e=this.get_adjusted_ptr();return 0!==e?e:this.excPtr}}function P(e){var t=h.buffer;try{return h.grow(e-t.byteLength+65535>>>16),y(),1}catch(e){}}function R(e){return r["_"+e]}I(E="wasmDbscan.wasm")||(T=E,E=r.locateFile?r.locateFile(T,c):c+T);var O="undefined"!=typeof TextDecoder?new TextDecoder("utf8"):void 0;function k(e,t,n,s,r){var i={string:e=>{var t=0;return null!=e&&0!==e&&(t=function(e){var t=function(e){for(var t=0,n=0;n<e.length;++n){var s=e.charCodeAt(n);s<=127?t++:s<=2047?t+=2:s>=55296&&s<=57343?(t+=4,++n):t+=3}return t}(e)+1,n=V(t);return function(e,t,n){!function(e,t,n,s){if(!(s>0))return 0;for(var r=n+s-1,i=0;i<e.length;++i){var o=e.charCodeAt(i);if(o>=55296&&o<=57343&&(o=65536+((1023&o)<<10)|1023&e.charCodeAt(++i)),o<=127){if(n>=r)break;t[n++]=o}else if(o<=2047){if(n+1>=r)break;t[n++]=192|o>>6,t[n++]=128|63&o}else if(o<=65535){if(n+2>=r)break;t[n++]=224|o>>12,t[n++]=128|o>>6&63,t[n++]=128|63&o}else{if(n+3>=r)break;t[n++]=240|o>>18,t[n++]=128|o>>12&63,t[n++]=128|o>>6&63,t[n++]=128|63&o}}t[n]=0}(e,p,t,n)}(e,n,t),n}(e)),t},array:e=>{var t,n,s=V(e.length);return t=e,n=s,m.set(t,n),s}},o=R(e),a=[],l=0;if(s)for(var c=0;c<s.length;c++){var u=i[n[c]];u?(0===l&&(l=G()),a[c]=u(s[c])):a[c]=s[c]}var h=o.apply(null,a);return function(e){return 0!==l&&B(l),function(e){return"string"===t?(n=e)?function(e,t,n){for(var s=t+n,r=t;e[r]&&!(r>=s);)++r;if(r-t>16&&e.buffer&&O)return O.decode(e.subarray(t,r));for(var i="";t<r;){var o=e[t++];if(128&o){var a=63&e[t++];if(192!=(224&o)){var l=63&e[t++];if((o=224==(240&o)?(15&o)<<12|a<<6|l:(7&o)<<18|a<<12|l<<6|63&e[t++])<65536)i+=String.fromCharCode(o);else{var c=o-65536;i+=String.fromCharCode(55296|c>>10,56320|1023&c)}}else i+=String.fromCharCode((31&o)<<6|a)}else i+=String.fromCharCode(o)}return i}(p,n,s):"":"boolean"===t?Boolean(e):e;var n,s}(e)}(h)}var D,F={__cxa_throw:function(e,t,n){throw new L(e).init(t,n),e},abort:function(){x("")},emscripten_memcpy_big:function(e,t,n){p.copyWithin(e,t,t+n)},emscripten_resize_heap:function(e){var t,n=p.length,s=2147483648;if((e>>>=0)>s)return!1;for(var r=1;r<=4;r*=2){var i=n*(1+.2/r);if(i=Math.min(i,e+100663296),P(Math.min(s,(t=Math.max(e,i))+(65536-t%65536)%65536)))return!0}return!1}},G=(function(){var e,t,s,i,o={env:F,wasi_snapshot_preview1:F};function a(e,t){var n,s=e.exports;return r.asm=s,h=r.asm.memory,y(),r.asm.__indirect_function_table,n=r.asm.__wasm_call_ctors,v.unshift(n),function(e){if(C--,r.monitorRunDependencies&&r.monitorRunDependencies(C),0==C&&(null!==A&&(clearInterval(A),A=null),S)){var t=S;S=null,t()}}(),s}if(C++,r.monitorRunDependencies&&r.monitorRunDependencies(C),r.instantiateWasm)try{return r.instantiateWasm(o,a)}catch(e){d("Module.instantiateWasm callback failed with error: "+e),n(e)}(e=u,t=E,s=o,i=function(e){a(e.instance)},e||"function"!=typeof WebAssembly.instantiateStreaming||I(t)||"function"!=typeof fetch?N(t,s,i):fetch(t,{credentials:"same-origin"}).then((function(e){return WebAssembly.instantiateStreaming(e,s).then(i,(function(e){return d("wasm streaming compile failed: "+e),d("falling back to ArrayBuffer instantiation"),N(t,s,i)}))}))).catch(n)}(),r._dbscan=function(){return(r._dbscan=r.asm.dbscan).apply(null,arguments)},r._malloc=function(){return(r._malloc=r.asm.malloc).apply(null,arguments)},r._free=function(){return(r._free=r.asm.free).apply(null,arguments)},function(){return(G=r.asm.stackSave).apply(null,arguments)}),B=function(){return(B=r.asm.stackRestore).apply(null,arguments)},V=function(){return(V=r.asm.stackAlloc).apply(null,arguments)},U=function(){return(U=r.asm.__cxa_is_pointer_type).apply(null,arguments)};function H(){function e(){D||(D=!0,r.calledRun=!0,g||($(v),t(r),r.onRuntimeInitialized&&r.onRuntimeInitialized(),function(){if(r.postRun)for("function"==typeof r.postRun&&(r.postRun=[r.postRun]);r.postRun.length;)e=r.postRun.shift(),w.unshift(e);var e;$(w)}()))}C>0||(function(){if(r.preRun)for("function"==typeof r.preRun&&(r.preRun=[r.preRun]);r.preRun.length;)e=r.preRun.shift(),b.unshift(e);var e;$(b)}(),C>0||(r.setStatus?(r.setStatus("Running..."),setTimeout((function(){setTimeout((function(){r.setStatus("")}),1),e()}),1)):e()))}if(r.ccall=k,r.cwrap=function(e,t,n,s){var r=!n||n.every((e=>"number"===e||"boolean"===e));return"string"!==t&&r&&!s?R(e):function(){return k(e,t,n,arguments)}},S=function e(){D||H(),D||(S=e)},r.preInit)for("function"==typeof r.preInit&&(r.preInit=[r.preInit]);r.preInit.length>0;)r.preInit.pop()();return H(),e.ready});"object"==typeof exports?e.exports=r:"function"==typeof define&&n.amdO?define([],(function(){return r})):"object"==typeof exports&&(exports.exportCppDbscanLib=r)},6254:(e,t,n)=>{"use strict";function s(e){return(t,n)=>e*t+n-Math.floor((t+2)*(t+1)/2)}n.d(t,{y:()=>s})},5697:(e,t,n)=>{"use strict";n.d(t,{Dz:()=>b,FV:()=>c,Jv:()=>S,KR:()=>l,MI:()=>w,NB:()=>p,UX:()=>m,WI:()=>d,Z3:()=>a,Zd:()=>h,_h:()=>u,aW:()=>g,bX:()=>A,fX:()=>v,kg:()=>o,s:()=>f,yU:()=>y});var s=n(9657),r=n(1040),i=n(708);r.gk.Tanimoto,r.gk.Dice,r.gk.Asymmetric,r.gk.BraunBlanquet,r.gk.Cosine,r.gk.Kulczynski,r.gk.McConnaughey,r.gk.RogotGoldberg,r.gk.Russel,r.gk.Sokal,r.gk.Hamming,r.gk.Euclidean,r.gk.Tanimoto,r.gk.Dice,r.gk.Asymmetric,r.gk.BraunBlanquet,r.gk.Cosine,r.gk.Kulczynski,r.gk.McConnaughey,r.gk.RogotGoldberg,r.gk.Russel,r.gk.Sokal,r.gk.Hamming,r.gk.Euclidean;const o=[r.gk.Tanimoto,r.gk.Dice,r.gk.Cosine];function a(e,t){const n=e.trueCount()+t.trueCount();if(0==n)return 1;const s=e.andWithCountBits(t,!0);return s/(n-s)}function l(e,t){return 1-a(e,t)}function c(e,t){return C(a(new s.Z(e,32*e.length),new s.Z(t,32*t.length)))}function u(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount();return 0==n?0:2*e.andWithCountBits(t,!0)/n}(e,t)}function h(e,t){return 1-function(e,t){const n=e.trueCount()*t.trueCount();return 0==n?0:e.andWithCountBits(t,!0)/Math.sqrt(n)}(e,t)}function d(e,t){return Math.sqrt(e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0))}function m(e,t){return e.trueCount()+t.trueCount()-2*e.andWithCountBits(t,!0)}function p(e,t){return 1-function(e,t){const n=e.trueCount()+t.trueCount(),s=e.andWithCountBits(t,!0);return s/(2*n-3*s)}(e,t)}function f(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),s=e.trueCount()*t.trueCount();return 0==s?0:e.andWithCountBits(t,!0)*n/(2*s)}(e,t))}function g(e,t){return C(function(e,t){const n=e.trueCount()+t.trueCount(),s=e.trueCount()*t.trueCount();return 0==s?0:(e.andWithCountBits(t,!0)*n-s)/s}(e,t))}function y(e,t){return 1-function(e,t){const n=Math.min(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t)}function b(e,t){return C(function(e,t){const n=Math.max(e.trueCount(),t.trueCount());return 0==n?0:e.andWithCountBits(t,!0)/n}(e,t))}function v(e,t){return C(function(e,t){return 0==e.length?0:e.andWithCountBits(t,!0)/e.length}(e,t))}function w(e,t){return C(function(e,t){const n=e.andWithCountBits(t,!0),s=e.countBits(!0)+t.countBits(!0),r=e.length,i=r-s+n;return n==r||i==r?1:n/s+i/(2*r-s)}(e,t))}function C(e){return 0===e?3402823e32:1/e-1}function A(e){if(e&&null!=e.range&&e.range>0){const t=e.range;return(e,n)=>Math.abs(e-n)/t}return(e,t)=>Math.abs(e-t)}function S(e){const t=function(e){const t=e?.mostCommon??new Set;return(e,n)=>{const s=e.length,r=n.length;let i=0,o=0,a=0;for(;o<s&&a<r;)e[o]===n[a]?(t?.has(e[o])||++i,++o,++a):e[o]<n[a]?++o:++a;return i}}(e);return(e,n)=>0===n.length||0===e.length?1e4:Math.min(e.length,n.length)/(t(e,n)+1e-4)}r.gk.Tanimoto,r.gk.Asymmetric,r.gk.Cosine,r.gk.Sokal,i.U.HAMMING,i.U.LEVENSHTEIN,i.U.MONOMER_CHEMICAL_DISTANCE,i.U.NEEDLEMANN_WUNSCH},3277:(e,t,n)=>{"use strict";n.d(t,{Ec:()=>c,dB:()=>a,n3:()=>s,q6:()=>o,sS:()=>l,ts:()=>i,vO:()=>r});const s="dim-red-preprocessing-function",r="supportedSemTypes",i="supportedTypes",o="supportedUnits",a="supportedDistanceFunctions",l="bypassLargeDataWarning",c="show-scatterplot-progress"},708:(e,t,n)=>{"use strict";function s(e={}){const t=function(){if(!e||!e.scoringMatrix||!e.alphabetIndexes)return(e,t)=>e===t?0:1;if(e.scoringMatrix.length!==Object.keys(e.alphabetIndexes).length)throw new Error("Scoring matrix and alphabet indexes should have the same length");const t=e.alphabetIndexes,n=e.scoringMatrix,s=Math.min(...Object.keys(t).map((e=>e.charCodeAt(0))))+1,r=new Float32Array((n.length+s)*(n.length+s));return Object.entries(t).forEach((([e,s])=>{const i=n[s];Object.entries(t).forEach((([t,s])=>{r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]=i[s]}))})),(e,t)=>1-r[e.charCodeAt(0)*n.length+t.charCodeAt(0)]}(),n=e?.threshold??0;return(e,s)=>{let r=0;const i=e.length,o=s.length,a=Math.ceil(Math.max(i,o)*(1-n));i!==o&&(r=Math.abs(i-o));let l=0;for(let n=0;n<Math.min(i,o);n++)if(e[n]!==s[n]&&(l+=t(e[n],s[n]),l>a))return 1;return l+=r,l/=Math.max(i,o),l}}n.d(t,{U:()=>o,o:()=>a});var r=n(1811);const i={gapOpen:1,gapExtend:.6,scoringMatrix:[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],alphabetIndexes:{A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23}};var o;!function(e){e.HAMMING="Hamming",e.LEVENSHTEIN="Levenshtein",e.NEEDLEMANN_WUNSCH="Needlemann-Wunsch",e.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance"}(o||(o={}));const a={[o.HAMMING]:s,[o.LEVENSHTEIN]:function(){return(e,t)=>(0,r.T)(e,t)/Math.max(e.length,t.length)},[o.NEEDLEMANN_WUNSCH]:function(e){const t=new Uint16Array(65536),{gapOpen:n,gapExtend:s,scoringMatrix:r,alphabetIndexes:o}={...i,...e};Object.entries(o).forEach((([e,n])=>t[e.charCodeAt(0)]=n));const a=[new Float32Array(1e4),new Float32Array(1e4)];return(e,i)=>{const o=new Array(e.length+1).fill(!1),l=new Array(e.length+1).fill(!1);let c=0,u=1;for(let t=1;t<e.length+1;t++)a[0][t]=-n-(t-1)*s,a[1][t]=0;a[0][0]=0;for(let h=1;h<i.length+1;h++){a[u][0]=-n-(h-1)*s;for(let d=1;d<e.length+1;d++){const m=a[c][d-1]+r[t[e.charCodeAt(d-1)]][t[i.charCodeAt(h-1)]],p=a[c][d]-(o[d]?s:n),f=a[u][d-1]-(l[d-1]?s:n);a[u][d]=Math.max(m,f,p),a[u][d]===m?(o[d]=!1,l[d]=!1):a[u][d]===f?(o[d]=!1,l[d]=!0):(o[d]=!0,l[d]=!1)}c=u,u=(u+1)%2}const h=Math.max(e.length,i.length);return(h-a[c][e.length])/h}},[o.MONOMER_CHEMICAL_DISTANCE]:s}},4628:(e,t,n)=>{"use strict";var s;n.d(t,{A:()=>s}),function(e){e.UMAP="UMAP",e.T_SNE="t-SNE"}(s||(s={}))},1040:(e,t,n)=>{"use strict";var s,r,i,o,a,l,c;n.d(t,{CF:()=>r,Qe:()=>a,W:()=>s,Yc:()=>l,gd:()=>o,gj:()=>c,gk:()=>i}),function(e){e.Levenshtein="Levenshtein",e.JaroWinkler="Jaro-Winkler",e.Manhattan="Manhattan",e.Onehot="One-Hot"}(s||(s={})),function(e){e.Euclidean="Euclidean"}(r||(r={})),function(e){e.Tanimoto="Tanimoto",e.Dice="Dice",e.Asymmetric="Asymmetric",e.BraunBlanquet="Braun-Blanquet",e.Cosine="Cosine",e.Kulczynski="Kulczynski",e.McConnaughey="Mc-Connaughey",e.RogotGoldberg="Rogot-Goldberg",e.Russel="Russel",e.Sokal="Sokal",e.Hamming="Hamming",e.Euclidean="Euclidean"}(i||(i={})),function(e){e.TanimotoIntArray="TanimotoIntArray"}(o||(o={})),function(e){e.Vector="Vector",e.String="String",e.BitArray="BitArray",e.MacroMolecule="MacroMolecule",e.Number="Number",e.IntArray="IntArray",e.NumberArray="NumberArray"}(a||(a={})),function(e){e.Difference="Difference"}(l||(l={})),function(e){e.CommonItems="Common Items"}(c||(c={}))},6361:(e,t,n)=>{"use strict";n.d(t,{W:()=>s.W});var s=n(1040);n(7861)},7861:(e,t,n)=>{"use strict";var s=n(1811),r=n(3979),i=n(5697),o=n(850),a=n(708),l=n(1040);const c={[l.CF.Euclidean]:o.dP},u={[l.W.Levenshtein]:s.T,[l.W.JaroWinkler]:r.H$,[l.W.Manhattan]:function(e,t){if(e.length!==t.length)return 1;{let n=0;for(let s=1;s<e.length;s++)n+=e[s]==t[s]?0:1;return n/e.length}},[l.W.Onehot]:function(e,t){return e===t?0:1}},h={[l.gk.Tanimoto]:i.KR,[l.gk.Dice]:i._h,[l.gk.Asymmetric]:i.yU,[l.gk.BraunBlanquet]:i.Dz,[l.gk.Cosine]:i.Zd,[l.gk.Kulczynski]:i.s,[l.gk.McConnaughey]:i.aW,[l.gk.RogotGoldberg]:i.MI,[l.gk.Russel]:i.fX,[l.gk.Sokal]:i.NB,[l.gk.Hamming]:i.UX,[l.gk.Euclidean]:i.WI},d={[l.gd.TanimotoIntArray]:i.FV},m={[l.Yc.Difference]:i.bX},p={[l.gj.CommonItems]:i.Jv},f={[l.Qe.Vector]:{[l.CF.Euclidean]:c[l.CF.Euclidean]},[l.Qe.String]:{[l.W.Levenshtein]:u[l.W.Levenshtein],[l.W.JaroWinkler]:u[l.W.JaroWinkler],[l.W.Manhattan]:u[l.W.Manhattan],[l.W.Onehot]:u[l.W.Onehot]},[l.Qe.BitArray]:{[l.gk.Tanimoto]:h[l.gk.Tanimoto],[l.gk.Dice]:h[l.gk.Dice],[l.gk.Asymmetric]:h[l.gk.Asymmetric],[l.gk.BraunBlanquet]:h[l.gk.BraunBlanquet],[l.gk.Cosine]:h[l.gk.Cosine],[l.gk.Kulczynski]:h[l.gk.Kulczynski],[l.gk.McConnaughey]:h[l.gk.McConnaughey],[l.gk.RogotGoldberg]:h[l.gk.RogotGoldberg],[l.gk.Russel]:h[l.gk.Russel],[l.gk.Sokal]:h[l.gk.Sokal]},[l.Qe.MacroMolecule]:{[a.U.HAMMING]:a.o[a.U.HAMMING],[a.U.LEVENSHTEIN]:a.o[a.U.LEVENSHTEIN],[a.U.NEEDLEMANN_WUNSCH]:a.o[a.U.NEEDLEMANN_WUNSCH],[a.U.MONOMER_CHEMICAL_DISTANCE]:a.o[a.U.MONOMER_CHEMICAL_DISTANCE]},[l.Qe.Number]:{[l.Yc.Difference]:m[l.Yc.Difference]},[l.Qe.IntArray]:{[l.gd.TanimotoIntArray]:d[l.gd.TanimotoIntArray]},[l.Qe.NumberArray]:{[l.gj.CommonItems]:p[l.gj.CommonItems]}};Object.keys(f).reduce(((e,t)=>{for(const n of Object.keys(f[t]))e[n]=t;return e}),{})},9657:(e,t,n)=>{"use strict";n.d(t,{Z:()=>s});class s{constructor(e,t=!1){if(this._length=0,this._version=0,this._updateLevel=0,this._selectedCount=0,this._selectedCountVersion=-1,this._selectedIndexesVersion=-1,this._versionedName="",this._versionedNameVersion=-1,this.SHRINK_THRESHOLD=256,"number"==typeof e){const n=e,r=s._createBuffer(n);if(t)for(let e=0;e<r.length;e++)r[e]=-1;this._data=r,this._length=n}else{if(!(e instanceof Uint32Array))throw new Error("Invalid constructor");this._data=e,this._length=t}}getRawData(){return this._data}assureGoez(e,t){if(e<0)throw new Error(`${t} should be greater than zero`)}assureInRange(e,t,n,s){if(e<t||e>n)throw new Error(`Argument ${s} (${e}) out of range (${t}, ${n})`)}copy(e,t,n){for(let s=0;s<n;s++)t[s]=e[s]}copyFrom(e){if(this._length!=e._length)throw new Error(`Lengths differ (${this._length} != ${e._length})`);this.copy(e._data,this._data,this.lengthInInts),this._version++}get length(){return this._length}get buffer(){return this._data}set buffer(e){this._data=e,this._version++}get version(){return this._version}set version(e){this._version=e}incrementVersion(e=!0){this._version++}get lengthInInts(){return Math.floor((this._length+31)/32)}get versionedName(){return this._version==this._versionedNameVersion?this._versionedName:""}set versionedName(e){this._versionedName=e,this._versionedNameVersion=this._version}get self(){return this}setLength(e){if(e<0)throw new Error("should be >= 0");if(e==this._length)return;const t=Math.floor((e+31)/32);if(t>this._data.length||t+this.SHRINK_THRESHOLD<this._data.length){const e=new Uint32Array(t);this.copy(this._data,e,t>this._data.length?this._data.length:t),this._data=e}e>this._length&&(this._length%32>0&&(this._data[this.lengthInInts-1]&=(1<<(this._length%32&31))-1),this._data.fill(0,this.lengthInInts,t)),this._length=e,this._version++}static fromAnd(e,t){if(e._length!=t._length)throw new Error(`Lengths differ (${e._length} != ${t._length})`);const n=new s(e._length);n._length=e._length,n._data=s._createBuffer(n._length),n._version=0;const r=e.lengthInInts;for(let s=0;s<r;s++)n._data[s]=e._data[s]&t._data[s];return n}static _createBuffer(e){return new Uint32Array(Math.floor((e+31)/32))}static fromValues(e){const t=new s(e.length);t._version=0;for(let n=0;n<t._length;n++)e[n]&&(t._data[Math.floor(n/32)]|=1<<(n%32&31));return t}static fromSeq(e,t){const n=new s(e);for(let s=0;s<e;++s)n.setBit(s,t(s));return n._version=0,n}static fromString(e){return s.fromSeq(e.length,(t=>"1"==e.charAt(t)))}static fromUint32Array(e,t){const n=new s(e);return n._data=t,n}static fromBytes(e){const t=e.length,n=new s(8*t);n._data=new Uint32Array(Math.floor((t+3)/4)),n._length=8*t;let r=0,i=0;for(;t-i>=4;)n._data[r++]=255&e[i]|(255&e[i+1])<<8|(255&e[i+2])<<16|(255&e[i+3])<<24,i+=4;return t-i==3&&(n._data[r]=(255&e[i+2])<<16),t-i==2&&(n._data[r]|=(255&e[i+1])<<8),t-i==1&&(n._data[r]|=255&e[i]),n._version=0,n}toString(){return`${this._length} bits, ${this.countBits(!0)} set`}equals(e){if(this==e)return!0;if(null==e)return!1;if(this._length!=e._length)return!1;if(0==this._length)return!0;for(let t=0;t<this._data.length-1;t++)if(this._data[t]!=e._data[t])return!1;for(let t=8*(this._data.length-1);t<this._length;t++)if(this.getBit(t)!=e.getBit(t))return!1;return!0}clone(){const e=new s(0,!1);return e._data=Uint32Array.from(this._data),e._length=this._length,e._version=this._version,e}init(e,t){this.setAll(!1,!1);for(let t=0;t<this._length;t++)e(t)&&(this._data[Math.floor(t/32)]|=1<<(t%32&31));return this.incrementVersion(t),this}invert(e=!0){for(let e=0;e<this._data.length;e++)this._data[e]^=-1;this.incrementVersion(e)}setAll(e,t=!1){const n=e?-1:0,s=this.lengthInInts;for(let e=0;e<s;e++)this._data[e]=n;this.incrementVersion(t)}setIndexes(e,t=!0,n=!0,s=!0){n&&this.setAll(!t,!1);for(const n of e)this.setFast(n,t);this.incrementVersion(s)}everyIndex(e,t=!0){for(const n of e)if(this.getBit(n)!=t)return!1;return!0}anyIndex(e,t=!0){for(const n of e)if(this.getBit(n)==t)return!0;return!1}setWhere(e,t=!0,n=!0,s=!0,r=!0){if(n&&r&&this.setAll(!t,!1),r)for(let n=0;n<this._length;n++)e(n)&&this.setFast(n,t);else for(let n=0;n<this._length;n++)this.setFast(n,e(n)?t:!t);this.incrementVersion(s)}getRange(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let s=e;s<t;++s)n.push(this.getBit(s));return s.fromValues(n)}getRangeAsList(e,t){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length,"to");const n=[];for(let s=e;s<t;++s)n.push(this.getBit(s));return n}setRange(e,t,n,s=!0){this.assureInRange(e,0,this._length-1,"from"),this.assureInRange(t,0,this._length-1,"to");const r=Math.min(e,t),i=Math.max(e,t);if(n)for(let e=r;e<=i;e++)this.setTrue(e);else for(let e=r;e<=i;e++)this.setFalse(e);return this.incrementVersion(s),this}setRandom(e,t,n=!0){if(e<0||e>this._length)throw new Error("n must be >= 0 && <= Count");e>this._length/2&&this.setRandom(this._length-e,!t),this.setAll(!t);for(let n=0;n<e;){const e=Math.floor(Math.random()*this._length);this.getBit(e)!=t&&(this.setFast(e,t),n++)}this.incrementVersion(n)}and(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]&=e._data[t];return this.incrementVersion(t),this}andNot(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");const n=this.lengthInInts;for(let t=0;t<n;t++)this._data[t]&=~e._data[t];return this.incrementVersion(t),this}notAnd(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]=~this._data[t]&e._data[t];return this.incrementVersion(t),this}not(e=!0){for(let e=0,t=this.lengthInInts;e<t;e++)this._data[e]=~this._data[e];return this.incrementVersion(e),this}or(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]|=e._data[t];return this.incrementVersion(t),this}xor(e,t=!0){if(this._length!=e._length)throw new Error("Array lengths differ.");for(let t=0,n=this.lengthInInts;t<n;t++)this._data[t]^=e._data[t];return this.incrementVersion(t),this}insertAt(e,t,n=!1){if(this.assureInRange(e,0,this._length,"pos"),0==t)return;const s=this._length;this.setLength(this._length+t);for(let n=s-1;n>=e;n--)this.setBit(n+t,this.getBit(n));for(let s=e;s<e+t;s++)this.setBit(s,n)}removeAt(e,t=1){if(t<0)throw new Error("n cannot be negative");if(this.assureInRange(e,0,this._length-t,"pos"),this.contains(!0))for(let n=e;n<this._length-t;n++)this.setBit(n,this.getBit(n+t));this.setLength(this._length-t)}removeByMask(e,t=!0){if(this._length!=e.length)throw new Error("length != mask.length");if(e==this)this.setLength(e.countBits(!t)),this.setAll(!t);else{let n=0;for(let s=-1;-1!=(s=e.findNext(s,!t));)this.setFast(n++,this.getBit(s));this._length=n,this._version++}return this}getBit(e){return 0!=(this._data[Math.floor(e/32)]&1<<(31&e))}setBit(e,t,n=!0){this.setFast(e,t),this._version++}setFast(e,t){t?this._data[Math.floor(e/32)]|=1<<(31&e):this._data[Math.floor(e/32)]&=~(1<<(31&e))}setTrue(e){this._data[Math.floor(e/32)]|=1<<(31&e)}setFalse(e){this._data[Math.floor(e/32)]&=~(1<<(31&e))}trueCount(){return this.countBits(!0)}falseCount(){return this.countBits(!1)}countBits(e){if(0==this._length)return 0;if(this._selectedCountVersion!=this._version){this._selectedCount=0;const e=this.lengthInInts;let t=0;for(;t<e-1;t++)for(let e=this._data[t];0!=e;e>>>=8)this._selectedCount+=s._onBitCount[255&e];let n=this._data[t];const r=31&this._length;for(0!=r&&(n&=~(4294967295<<r));0!=n;n>>>=8)this._selectedCount+=s._onBitCount[255&n];this._selectedCountVersion=this._version}return e?this._selectedCount:this._length-this._selectedCount}countWhere(e){let t=0;if(this.trueCount()==this._length)for(let n=0;n<this._length;n++)t+=e(n)?1:0;else for(let n=-1;-1!=(n=this.findNext(n,!0));)t+=e(n)?1:0;return t}andWithCountBits(e,t){if(0==this._length)return 0;let n=0;const r=this.lengthInInts;let i=0;for(;i<r-1;i++)for(let t=this._data[i]&e._data[i];0!=t;t>>>=8)n+=s._onBitCount[255&t];let o=this._data[i]&e._data[i];const a=31&this._length;for(0!=a&&(o&=~(4294967295<<a));0!=o;o>>>=8)n+=s._onBitCount[255&o];return t?n:this._length-n}clear(){this.setLength(0)}contains(e){return this.findNext(-1,e)>=0}get allTrue(){return this.countBits(!0)==this._length}get allFalse(){return this.countBits(!1)==this._length}get anyTrue(){return this.countBits(!0)>0}get anyFalse(){return this.countBits(!1)>0}findNext(e,t=!0){if(this.assureInRange(e,-1,this._length,"index"),e>=this._length-1)return-1;let n=31&(e=e<0?0:e+1);const r=this.lengthInInts;for(let i=Math.floor(e/32);i<r;i++){let r=t?this._data[i]:~this._data[i];if(0!=n)r&=4294967295<<n&4294967295,n=0;else if(!t&&-4294967296==r)continue;for(let t=0;0!=r;t+=8,r>>>=8){const n=s._firstOnBit[255&r];if(n>=0)return(e=n+32*i+t)>=this._length?-1:e}}return-1}findPrev(e,t=!0){if(0==e)return-1;this.assureInRange(e,-1,this._length,"index");let n=1+(e=e<0?this._length-1:e-1)&31;for(let r=Math.floor(e/32);r>=0;r--){let e=t?this._data[r]:~this._data[r];0!=n&&(e&=~(4294967295<<n),n=0);for(let t=24;0!=e;t-=8,e<<=8){const n=s._lastOnBit[e>>>24];if(n>=0)return n+32*r+t}}return-1}}s._onBitCount=Int8Array.from([0,1,1,2,1,2,2,3,1,2,2,3,2,3,3,4,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,1,2,2,3,2,3,3,4,2,3,3,4,3,4,4,5,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,2,3,3,4,3,4,4,5,3,4,4,5,4,5,5,6,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,3,4,4,5,4,5,5,6,4,5,5,6,5,6,6,7,4,5,5,6,5,6,6,7,5,6,6,7,6,7,7,8]),s._firstOnBit=Int8Array.from([-1,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,7,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,6,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,5,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0,4,0,1,0,2,0,1,0,3,0,1,0,2,0,1,0]),s._lastOnBit=Int8Array.from([-1,0,1,1,2,2,2,2,3,3,3,3,3,3,3,3,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,4,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,5,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,6,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7,7])},279:(e,t,n)=>{"use strict";function s(e,t,n){function s(e,t){let n=null,s=null;for(const r of e){const e=t(r);(null==s||e>s)&&(n=r,s=e)}return n}const r=[(o=e-1,Math.floor(function(e){return Math.random()*e}(o)))],i=new Set;var o;for(let t=0;t<e;++t)r.includes(t)||i.add(t);for(;r.length<t;){const e=s(i.values(),(e=>Math.min.apply(Math,r.map((function(t,s){return n(e,t)})))));null!=e&&(r.push(e),i.delete(e))}return r}n.d(t,{L:()=>s})},2997:(e,t,n)=>{"use strict";n.d(t,{gw:()=>a,zg:()=>o}),n(4469);var s=n(976);n(9133),s.DataFrame.fromCsv('countries,fasta,smiles,molregno,LON,Zip Code,Street Address Line 1,ImageUrl,user_id,error_message,xray,flag,magnitude,CS-id,pdb_id,accel_a,time_offset,chart,fit,Questions,empty_number,empty_string\nBelgium,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C(=O)OCCCc1cccnc1)c2cccc(c2)C(=O)c3ccccc3,1480014,36.276729583740234,995042300,14016 ROUTE 31W,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,1,1,1QBS,1,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.497360340644872, 1.7058694986686864, 5.278052678195135, 0.16000320889028383],""points"":[{""x"":0.10000000149011612,""y"":2.374499797821045},{""x"":0.6000000238418579,""y"":2.6242473125457764},{""x"":1.100000023841858,""y"":2.367267608642578},{""x"":1.600000023841858,""y"":2.6723148822784424},{""x"":2.0999999046325684,""y"":2.6537344455718994},{""x"":2.5999999046325684,""y"":2.3651671409606934},{""x"":3.0999999046325684,""y"":2.5654284954071045},{""x"":3.5999999046325684,""y"":2.4160959720611572},{""x"":4.099999904632568,""y"":2.286726713180542},{""x"":4.599999904632568,""y"":2.5100042819976807},{""x"":5.099999904632568,""y"":1.6676985025405884},{""x"":5.599999904632568,""y"":0.680136501789093},{""x"":6.099999904632568,""y"":0.3391543924808502},{""x"":6.599999904632568,""y"":0.09038983285427094},{""x"":7.099999904632568,""y"":0.19802775979042053}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[7.525235855508179, 1.3186911876809984, 5.335672608564294, 0.7860743343958098],""points"":[{""x"":0.10000000149011612,""y"":7.988070487976074},{""x"":0.6000000238418579,""y"":7.018453121185303},{""x"":1.100000023841858,""y"":8.115279197692871},{""x"":1.600000023841858,""y"":7.486658096313477},{""x"":2.0999999046325684,""y"":7.396438121795654},{""x"":2.5999999046325684,""y"":7.477052211761475},{""x"":3.0999999046325684,""y"":6.913095474243164},{""x"":3.5999999046325684,""y"":8.01385498046875},{""x"":4.099999904632568,""y"":6.985900402069092},{""x"":4.599999904632568,""y"":6.970335960388184},{""x"":5.099999904632568,""y"":5.448817253112793},{""x"":5.599999904632568,""y"":2.5534818172454834},{""x"":6.099999904632568,""y"":1.893947958946228},{""x"":6.599999904632568,""y"":0.6340042352676392},{""x"":7.099999904632568,""y"":0.8403874039649963}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,100,abc\nBurundi,MDYKETLLMPKTDFPMRGGLPNKEPQIQEKW,COc1ccc2cc(ccc2c1)C(C)C(=O)Oc3ccc(C)cc3OC,1480015,36.276729583740234,995073444,80 STATE HIGHWAY 310,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,2,2,1ZP8,2,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.431460753103398, 2.1691498799246745, 5.266445597102774, 0.7825762827017926],""points"":[{""x"":0.10000000149011612,""y"":4.751083850860596},{""x"":0.6000000238418579,""y"":4.203000068664551},{""x"":1.100000023841858,""y"":4.415858745574951},{""x"":1.600000023841858,""y"":4.68414306640625},{""x"":2.0999999046325684,""y"":4.198400974273682},{""x"":2.5999999046325684,""y"":4.179222106933594},{""x"":3.0999999046325684,""y"":4.638473987579346},{""x"":3.5999999046325684,""y"":4.708553314208984},{""x"":4.099999904632568,""y"":4.291589260101318},{""x"":4.599999904632568,""y"":4.038082599639893},{""x"":5.099999904632568,""y"":3.4349939823150635},{""x"":5.599999904632568,""y"":1.2194708585739136},{""x"":6.099999904632568,""y"":1.1920831203460693},{""x"":6.599999904632568,""y"":0.5352635979652405},{""x"":7.099999904632568,""y"":0.3346920311450958}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.339458017970126, -1.0734184310171178, 4.746332950550934, 0.2482416857595658],""points"":[{""x"":0.10000000149011612,""y"":0.2139337658882141},{""x"":0.6000000238418579,""y"":0.4269562065601349},{""x"":1.100000023841858,""y"":0.2441573292016983},{""x"":1.600000023841858,""y"":0.146635964512825},{""x"":2.0999999046325684,""y"":0.08818462491035461},{""x"":2.5999999046325684,""y"":0.2560656666755676},{""x"":3.0999999046325684,""y"":0.42434045672416687},{""x"":3.5999999046325684,""y"":0.37111231684684753},{""x"":4.099999904632568,""y"":0.5581737160682678},{""x"":4.599999904632568,""y"":1.183590054512024},{""x"":5.099999904632568,""y"":1.5629843473434448},{""x"":5.599999904632568,""y"":2.3211288452148438},{""x"":6.099999904632568,""y"":2.229961633682251},{""x"":6.599999904632568,""y"":2.2560226917266846},{""x"":7.099999904632568,""y"":2.2142398357391357}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCameroon,MIEVFLFGIVLGLIPITLAGLFVTAYLQYRRGDQLDL,COc1ccc2cc(ccc2c1)C(C)C(=O)OCCCc3cccnc3,1480016,36.26095962524414,995153596,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,3,3,2BDJ,3,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[4.6760652578642325, 0.9046956320756703, 5.651408971856738, 0.07738846012184185],""points"":[{""x"":0.10000000149011612,""y"":4.32425594329834},{""x"":0.6000000238418579,""y"":4.668442249298096},{""x"":1.100000023841858,""y"":4.379785060882568},{""x"":1.600000023841858,""y"":5.0345139503479},{""x"":2.0999999046325684,""y"":4.878653526306152},{""x"":2.5999999046325684,""y"":4.3451313972473145},{""x"":3.0999999046325684,""y"":4.336992263793945},{""x"":3.5999999046325684,""y"":5.037430286407471},{""x"":4.099999904632568,""y"":5.0092692375183105},{""x"":4.599999904632568,""y"":4.151902675628662},{""x"":5.099999904632568,""y"":3.4066951274871826},{""x"":5.599999904632568,""y"":2.3732759952545166},{""x"":6.099999904632568,""y"":1.673728108406067},{""x"":6.599999904632568,""y"":0.48574790358543396},{""x"":7.099999904632568,""y"":0.2783052325248718}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[2.938395863010111, -1.4658480661392117, 5.462702751996584, 0.3473139023615039],""points"":[{""x"":0.10000000149011612,""y"":0.4941710829734802},{""x"":0.6000000238418579,""y"":0.15323974192142487},{""x"":1.100000023841858,""y"":0.46373432874679565},{""x"":1.600000023841858,""y"":0.3370431363582611},{""x"":2.0999999046325684,""y"":0.5179030299186707},{""x"":2.5999999046325684,""y"":0.27899765968322754},{""x"":3.0999999046325684,""y"":0.22075064480304718},{""x"":3.5999999046325684,""y"":0.5789918899536133},{""x"":4.099999904632568,""y"":0.21169911324977875},{""x"":4.599999904632568,""y"":0.27857646346092224},{""x"":5.099999904632568,""y"":1.0906332731246948},{""x"":5.599999904632568,""y"":1.8520300388336182},{""x"":6.099999904632568,""y"":2.7177059650421143},{""x"":6.599999904632568,""y"":2.8680918216705322},{""x"":7.099999904632568,""y"":3.2413077354431152}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCanada,MMELVLKTIIGPIVVGVVLRIVDKWLNKDK,CC(C(=O)NCCS)c1cccc(c1)C(=O)c2ccccc2,1480017,36.26095962524414,99515,30-56 WHITESTONE EXPY,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,4,4,1IAN,4,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[0.8597390975430008, 1.0957625732481946, 5.260537067987958, 0.07974187998177736],""points"":[{""x"":0.10000000149011612,""y"":0.8190152645111084},{""x"":0.6000000238418579,""y"":0.8421689867973328},{""x"":1.100000023841858,""y"":0.8740922212600708},{""x"":1.600000023841858,""y"":0.8924275040626526},{""x"":2.0999999046325684,""y"":0.8249067664146423},{""x"":2.5999999046325684,""y"":0.9327669143676758},{""x"":3.0999999046325684,""y"":0.8522974252700806},{""x"":3.5999999046325684,""y"":0.8174492716789246},{""x"":4.099999904632568,""y"":0.8394647240638733},{""x"":4.599999904632568,""y"":0.7139387726783752},{""x"":5.099999904632568,""y"":0.5561167597770691},{""x"":5.599999904632568,""y"":0.3276226818561554},{""x"":6.099999904632568,""y"":0.12479474395513535},{""x"":6.599999904632568,""y"":0.13006797432899475},{""x"":7.099999904632568,""y"":0.059702079743146896}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.760930219582546, 1.6591793293833013, 4.667155929720851, 0.7858109544121652],""points"":[{""x"":0.10000000149011612,""y"":6.156993389129639},{""x"":0.6000000238418579,""y"":5.236701965332031},{""x"":1.100000023841858,""y"":6.010560512542725},{""x"":1.600000023841858,""y"":5.495512962341309},{""x"":2.0999999046325684,""y"":6.087770462036133},{""x"":2.5999999046325684,""y"":5.79986572265625},{""x"":3.0999999046325684,""y"":5.597546577453613},{""x"":3.5999999046325684,""y"":5.520902156829834},{""x"":4.099999904632568,""y"":5.360654354095459},{""x"":4.599999904632568,""y"":3.5539746284484863},{""x"":5.099999904632568,""y"":1.577236294746399},{""x"":5.599999904632568,""y"":1.0001264810562134},{""x"":6.099999904632568,""y"":0.9305797815322876},{""x"":6.599999904632568,""y"":0.6033638715744019},{""x"":7.099999904632568,""y"":0.4203685522079468}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nColombia,MDRTDEVSNHTHDKPTLTWFEEIFEEYHSPFHN,FC(F)(F)c1ccc(OC2CCNCC2)cc1,1480029,36.3309440612793,995152050,1 COURT HOUSE SQUARE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,5,5,4UJ1,5,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[6.4995088314153655, 2.4270351004539914, 5.178659535348579, 0.625653346241577],""points"":[{""x"":0.10000000149011612,""y"":6.496231555938721},{""x"":0.6000000238418579,""y"":6.42543363571167},{""x"":1.100000023841858,""y"":7.040063858032227},{""x"":1.600000023841858,""y"":6.1115403175354},{""x"":2.0999999046325684,""y"":6.680728435516357},{""x"":2.5999999046325684,""y"":6.406774520874023},{""x"":3.0999999046325684,""y"":6.611269474029541},{""x"":3.5999999046325684,""y"":5.889094352722168},{""x"":4.099999904632568,""y"":6.75344705581665},{""x"":4.599999904632568,""y"":6.361435890197754},{""x"":5.099999904632568,""y"":4.1666975021362305},{""x"":5.599999904632568,""y"":1.172118902206421},{""x"":6.099999904632568,""y"":0.801048994064331},{""x"":6.599999904632568,""y"":0.4640021026134491},{""x"":7.099999904632568,""y"":0.0010357667924836278}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[1.4734381347446401, 1.1649805188074196, 4.82958608866421, 0.09500545496710007],""points"":[{""x"":0.10000000149011612,""y"":1.5279096364974976},{""x"":0.6000000238418579,""y"":1.3559974431991577},{""x"":1.100000023841858,""y"":1.5246378183364868},{""x"":1.600000023841858,""y"":1.5567657947540283},{""x"":2.0999999046325684,""y"":1.4114240407943726},{""x"":2.5999999046325684,""y"":1.4045010805130005},{""x"":3.0999999046325684,""y"":1.4769829511642456},{""x"":3.5999999046325684,""y"":1.4875500202178955},{""x"":4.099999904632568,""y"":1.2991987466812134},{""x"":4.599999904632568,""y"":0.922961413860321},{""x"":5.099999904632568,""y"":0.6520044803619385},{""x"":5.599999904632568,""y"":0.15350978076457977},{""x"":6.099999904632568,""y"":0.1078903079032898},{""x"":6.599999904632568,""y"":0.17276449501514435},{""x"":7.099999904632568,""y"":0.14066608250141144}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCosta Rica,MKSTKEEIQTIKTLLKDSRTAKYHKRLQIVL,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCCc3ccccc3,1480018,36.3309440612793,995084218,4041 SOUTHWESTERN BLVD,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,6,6,2BPW,6,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.4833641843311227, -1.8945978742090062, 4.671127708092568, 0.24159861311815153],""points"":[{""x"":0.10000000149011612,""y"":0.0969524160027504},{""x"":0.6000000238418579,""y"":0.028483040630817413},{""x"":1.100000023841858,""y"":0.22087176144123077},{""x"":1.600000023841858,""y"":0.0068915546871721745},{""x"":2.0999999046325684,""y"":0.4305879771709442},{""x"":2.5999999046325684,""y"":0.44774115085601807},{""x"":3.0999999046325684,""y"":0.45346319675445557},{""x"":3.5999999046325684,""y"":0.2370593100786209},{""x"":4.099999904632568,""y"":0.4657953977584839},{""x"":4.599999904632568,""y"":1.155200719833374},{""x"":5.099999904632568,""y"":2.2294070720672607},{""x"":5.599999904632568,""y"":2.4311530590057373},{""x"":6.099999904632568,""y"":2.33846116065979},{""x"":6.599999904632568,""y"":2.608201026916504},{""x"":7.099999904632568,""y"":2.8136143684387207}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.224573521642033, 1.4454033924198528, 5.6014197746076535, 0.2823216054197577],""points"":[{""x"":0.10000000149011612,""y"":4.95027494430542},{""x"":0.6000000238418579,""y"":5.1754679679870605},{""x"":1.100000023841858,""y"":5.276752948760986},{""x"":1.600000023841858,""y"":5.589294910430908},{""x"":2.0999999046325684,""y"":5.616994857788086},{""x"":2.5999999046325684,""y"":5.120813846588135},{""x"":3.0999999046325684,""y"":5.340766906738281},{""x"":3.5999999046325684,""y"":4.876471042633057},{""x"":4.099999904632568,""y"":4.94999361038208},{""x"":4.599999904632568,""y"":5.162564754486084},{""x"":5.099999904632568,""y"":4.399557590484619},{""x"":5.599999904632568,""y"":2.7977969646453857},{""x"":6.099999904632568,""y"":1.0229872465133667},{""x"":6.599999904632568,""y"":0.48275601863861084},{""x"":7.099999904632568,""y"":0.10408931970596313}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nCuba,MHAILRYFIRRLFYHIFYKIYSLISKKHQSLPSDVRQF,COc1ccc2c(c1)c(CC(=O)N3CCCC3C(=O)Oc4ccc(C)cc4OC)c(C)n2C(=O)c5ccc(Cl)cc5,1480019,36.33115768432617,995081928,1227 US HIGHWAY 11,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,7,7,1QBS,7,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.320838679713925, -1.2421619987316728, 4.831325425225256, 0.3236011098403072],""points"":[{""x"":0.10000000149011612,""y"":0.3727470338344574},{""x"":0.6000000238418579,""y"":0.12365014106035233},{""x"":1.100000023841858,""y"":0.48422467708587646},{""x"":1.600000023841858,""y"":0.2264465093612671},{""x"":2.0999999046325684,""y"":0.16821794211864471},{""x"":2.5999999046325684,""y"":0.3879014551639557},{""x"":3.0999999046325684,""y"":0.5470244884490967},{""x"":3.5999999046325684,""y"":0.3419053554534912},{""x"":4.099999904632568,""y"":0.7655120491981506},{""x"":4.599999904632568,""y"":1.2346516847610474},{""x"":5.099999904632568,""y"":2.453336715698242},{""x"":5.599999904632568,""y"":2.9565491676330566},{""x"":6.099999904632568,""y"":3.335299491882324},{""x"":6.599999904632568,""y"":3.240290880203247},{""x"":7.099999904632568,""y"":3.1107218265533447}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.6401853521511094, 1.26211588875013, 5.399028074402744, 0.5089580830068091],""points"":[{""x"":0.10000000149011612,""y"":3.8585598468780518},{""x"":0.6000000238418579,""y"":3.6077206134796143},{""x"":1.100000023841858,""y"":3.855252265930176},{""x"":1.600000023841858,""y"":3.619039297103882},{""x"":2.0999999046325684,""y"":3.839388370513916},{""x"":2.5999999046325684,""y"":3.335283041000366},{""x"":3.0999999046325684,""y"":3.571141481399536},{""x"":3.5999999046325684,""y"":3.4155046939849854},{""x"":4.099999904632568,""y"":3.7316646575927734},{""x"":4.599999904632568,""y"":3.0680155754089355},{""x"":5.099999904632568,""y"":2.891066551208496},{""x"":5.599999904632568,""y"":1.6022753715515137},{""x"":6.099999904632568,""y"":0.7652576565742493},{""x"":6.599999904632568,""y"":0.6875326037406921},{""x"":7.099999904632568,""y"":0.5828871726989746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nItaly,MSNFHNEHVMQFYRNNLKTKGVFGRQ,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO[N+](=O)[O-],1480020,36.33115768432617,99502,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,8,8,1ZP8,8,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[2.293592105923809, 1.3781586549141835, 5.1025898038676605, 0.03493851245291291],""points"":[{""x"":0.10000000149011612,""y"":2.1287283897399902},{""x"":0.6000000238418579,""y"":2.267972230911255},{""x"":1.100000023841858,""y"":2.398442506790161},{""x"":1.600000023841858,""y"":2.5130622386932373},{""x"":2.0999999046325684,""y"":2.3255116939544678},{""x"":2.5999999046325684,""y"":2.127340793609619},{""x"":3.0999999046325684,""y"":2.47259783744812},{""x"":3.5999999046325684,""y"":2.131181478500366},{""x"":4.099999904632568,""y"":2.090421438217163},{""x"":4.599999904632568,""y"":2.02299165725708},{""x"":5.099999904632568,""y"":1.1105059385299683},{""x"":5.599999904632568,""y"":0.4494485855102539},{""x"":6.099999904632568,""y"":0.1375635862350464},{""x"":6.599999904632568,""y"":0.036351121962070465},{""x"":7.099999904632568,""y"":0.1619771122932434}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.953125499439879, 1.2528620255306528, 5.187637440149802, 0.3110348753260886],""points"":[{""x"":0.10000000149011612,""y"":5.6585283279418945},{""x"":0.6000000238418579,""y"":5.911152362823486},{""x"":1.100000023841858,""y"":5.924920082092285},{""x"":1.600000023841858,""y"":5.8469438552856445},{""x"":2.0999999046325684,""y"":5.929472923278809},{""x"":2.5999999046325684,""y"":6.190037727355957},{""x"":3.0999999046325684,""y"":6.236179828643799},{""x"":3.5999999046325684,""y"":6.141019344329834},{""x"":4.099999904632568,""y"":5.295210838317871},{""x"":4.599999904632568,""y"":5.265801906585693},{""x"":5.099999904632568,""y"":3.3722851276397705},{""x"":5.599999904632568,""y"":1.8299226760864258},{""x"":6.099999904632568,""y"":0.32690900564193726},{""x"":6.599999904632568,""y"":0.6274543404579163},{""x"":7.099999904632568,""y"":0.8441857099533081}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nRwanda,MPNSEPASLLELFNSIATQGELVRSLKAGNASK,CC(C)Cc1ccc(cc1)C(C)C(=O)N2CCCC2C(=O)OCCO,1480021,36.33137130737305,995037247,"168-46 91ST AVE., 2ND FLR",https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,9,2BDJ,9,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[3.8209972202654474, 1.3779216716448506, 5.299882228439686, 0.06040645519069608],""points"":[{""x"":0.10000000149011612,""y"":3.7821109294891357},{""x"":0.6000000238418579,""y"":3.542433023452759},{""x"":1.100000023841858,""y"":3.7008674144744873},{""x"":1.600000023841858,""y"":3.717301607131958},{""x"":2.0999999046325684,""y"":4.024452209472656},{""x"":2.5999999046325684,""y"":4.013899326324463},{""x"":3.0999999046325684,""y"":3.945094347000122},{""x"":3.5999999046325684,""y"":3.866621971130371},{""x"":4.099999904632568,""y"":3.7461626529693604},{""x"":4.599999904632568,""y"":3.3454740047454834},{""x"":5.099999904632568,""y"":2.61944317817688},{""x"":5.599999904632568,""y"":0.999405026435852},{""x"":6.099999904632568,""y"":0.46259793639183044},{""x"":6.599999904632568,""y"":0.054134611040353775},{""x"":7.099999904632568,""y"":0.05711187422275543}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[5.6318079657726035, 1.8495493770000595, 5.391793312471116, 0.17060707587348442],""points"":[{""x"":0.10000000149011612,""y"":5.458079814910889},{""x"":0.6000000238418579,""y"":5.554427146911621},{""x"":1.100000023841858,""y"":5.799983024597168},{""x"":1.600000023841858,""y"":5.364140033721924},{""x"":2.0999999046325684,""y"":5.864485740661621},{""x"":2.5999999046325684,""y"":5.4509806632995605},{""x"":3.0999999046325684,""y"":5.702574729919434},{""x"":3.5999999046325684,""y"":5.7314534187316895},{""x"":4.099999904632568,""y"":5.5123443603515625},{""x"":4.599999904632568,""y"":5.724395751953125},{""x"":5.099999904632568,""y"":4.354506969451904},{""x"":5.599999904632568,""y"":1.7307666540145874},{""x"":6.099999904632568,""y"":0.6305936574935913},{""x"":6.599999904632568,""y"":0.035183437168598175},{""x"":7.099999904632568,""y"":0.7575169205665588}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\nSwitzerland,IRVVGRYLIEVWKAAGMDMDKVLFLWSSDEI,CN1CCC(CC1)Oc2ccc(cc2)C(F)(F)F,1480028,36.33137130737305,99504,92-11 179TH PLACE,https://datagrok.ai/img/slides/access-db-connect.png,id,ErrorMessage,"COMPND \nATOM \nEND",flag,9,10,1IAN,10,1.23,<chart></chart>,"{""series"":[{""name"":""Run:2023-08-08"",""fitFunction"":""sigmoid"",""fitLineColor"":""#1f77b4"",""pointColor"":""#1f77b4"",""showPoints"":""points"",""parameters"":[1.1190255865097471, 2.3163895161544437, 5.4968866182279195, 0.2035204047289052],""points"":[{""x"":0.10000000149011612,""y"":1.1057683229446411},{""x"":0.6000000238418579,""y"":1.1019697189331055},{""x"":1.100000023841858,""y"":1.0818607807159424},{""x"":1.600000023841858,""y"":1.062997817993164},{""x"":2.0999999046325684,""y"":1.046447515487671},{""x"":2.5999999046325684,""y"":1.1217249631881714},{""x"":3.0999999046325684,""y"":1.2166996002197266},{""x"":3.5999999046325684,""y"":1.215477705001831},{""x"":4.099999904632568,""y"":1.0581893920898438},{""x"":4.599999904632568,""y"":1.1747995615005493},{""x"":5.099999904632568,""y"":1.0181127786636353},{""x"":5.599999904632568,""y"":0.5344523191452026},{""x"":6.099999904632568,""y"":0.2569526433944702},{""x"":6.599999904632568,""y"":0.1912207305431366},{""x"":7.099999904632568,""y"":0.15060538053512573}]},{""name"":""Run:2023-08-08"",""fitLineColor"":""#ffbb78"",""pointColor"":""#ffbb78"",""showPoints"":""points"",""parameters"":[3.1038581025805785, 2.0032224204185245, 5.087602825989163, 0.13277988512492753],""points"":[{""x"":0.10000000149011612,""y"":3.0498509407043457},{""x"":0.6000000238418579,""y"":2.805217742919922},{""x"":1.100000023841858,""y"":3.3415253162384033},{""x"":1.600000023841858,""y"":3.0549843311309814},{""x"":2.0999999046325684,""y"":3.250074863433838},{""x"":2.5999999046325684,""y"":3.0432586669921875},{""x"":3.0999999046325684,""y"":3.265852451324463},{""x"":3.5999999046325684,""y"":2.9475724697113037},{""x"":4.099999904632568,""y"":3.1929898262023926},{""x"":4.599999904632568,""y"":2.7460060119628906},{""x"":5.099999904632568,""y"":1.6175861358642578},{""x"":5.599999904632568,""y"":0.3006608486175537},{""x"":6.099999904632568,""y"":0.3444803059101105},{""x"":6.599999904632568,""y"":0.015537971630692482},{""x"":7.099999904632568,""y"":0.5527358055114746}]}],""chartOptions"":{""xAxisName"":""Conc."",""yAxisName"":""Activity"",""title"":""Dose-Response curves""}}",text,,\n,,,,,,,,,,,,,,,,,,,,,').columns.add(s.Column.fromList(s.TYPE.BYTE_ARRAY,"BinaryImage",Array.from(new Uint8Array(11))));var r,i=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function o(e,t,n,s=0,r="timeout"){return i(this,void 0,void 0,(function*(){return new Promise(((i,o)=>{const a=e.subscribe((e=>{try{t(e),i("OK")}catch(e){o(e)}finally{a.unsubscribe(),clearTimeout(l)}})),l=setTimeout((()=>{a.unsubscribe(),o(r)}),s);n()}))}))}function a(e){return i(this,void 0,void 0,(function*(){yield new Promise((t=>setTimeout(t,e)))}))}console.log.bind(console),console.info.bind(console),console.warn.bind(console),console.error.bind(console),function(e){e.notNull=function(e,t){if(null==e)throw new Error(`${null==t?"Value":t} not defined`)}}(r||(r={})),s.DataFrame.fromColumns([s.Column.fromStrings("col",["val1","val2","val3"])])},850:(e,t,n)=>{"use strict";function s(e=!1,t="Assertion error."){if(!e)throw new Error(t)}function r(e){let t=0;for(let n=0;n<e.length;n++)t+=e[n]*e[n];return Math.sqrt(t)}function i(e,t){if(e.length!=t.length)throw new Error("The dimensionality of the vectors must match");let n=0;for(let s=0;s<e.length;s++)n+=e[s]*t[s];return n}function o(e,t){let n=0;const s=e.length;if(s!==t.length)throw new Error("The dimensionality of the vectors must match");for(let r=0;r<s;++r)n+=Math.pow(e[r]-t[r],2);return Math.sqrt(n)}function a(e){const t=e.length;let n=0,s=0;for(let r=0;r<t;++r)n+=e[r],s+=Math.pow(e[r],2);const r=n/t,i=1/Math.sqrt(s/t-Math.pow(r,2));for(let n=0;n<t;++n)e[n]=(e[n]-r)*i;return e}n.d(t,{$G:()=>r,Fv:()=>a,MA:()=>i,dP:()=>o,hu:()=>s})},3351:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1581),r=n(3487),i=n(7023),o=n(4815),a=n(4181),l=n(2141),c="errorMessage",u=new s.Name("emUsed"),h={required:"missingProperty",dependencies:"property",dependentRequired:"property"},d=/\$\{[^}]+\}/,m=/\$\{([^}]+)\}/g,p=/^""\s*\+\s*|\s*\+\s*""$/g;const f=(e,t={})=>{if(!e.opts.allErrors)throw new Error("ajv-errors: Ajv option allErrors must be true");if(e.opts.jsPropertySyntax)throw new Error("ajv-errors: ajv option jsPropertySyntax is not supported");return e.addKeyword(function(e){return{keyword:c,schemaType:["string","object"],post:!0,code(t){const{gen:n,data:f,schema:g,schemaValue:y,it:b}=t;if(!1===b.createErrors)return;const v=g,w=r.strConcat(l.default.instancePath,b.errorPath);function C(e,t){return r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,s._`${e}.instancePath === ${w}`,s._`${e}.keyword in ${t}`,s._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,s._`/^\\/[^\\/]*$/.test(${e}.schemaPath.slice(${b.errSchemaPath.length}))`)}function A(e,t){const s=[];for(const n in e){const e=t[n];d.test(e)&&s.push([n,x(e)])}return n.object(...s)}function S(e){return d.test(e)?new i._Code(i.safeStringify(e).replace(m,((e,t)=>`" + JSON.stringify(${o.getData(t,b)}) + "`)).replace(p,"")):s.stringify(e)}function x(e){return s._`function(){return ${S(e)}}`}n.if(s._`${l.default.errors} > 0`,(()=>{if("object"==typeof v){const[i,o]=function(e){let t,n;for(const s in e){if("properties"===s||"items"===s)continue;const r=e[s];if("object"==typeof r){t||(t={});const e=t[s]={};for(const t in r)e[t]=[]}else n||(n={}),n[s]=[]}return[t,n]}(v);o&&function(r){const i=n.const("emErrors",s.stringify(r)),o=n.const("templates",A(r,g));n.forOf("err",l.default.vErrors,(e=>n.if(C(e,i),(()=>n.code(s._`${i}[${e}.keyword].push(${e})`).assign(s._`${e}.${u}`,!0)))));const{singleError:c}=e;if(c){const e=n.let("message",s._`""`),r=n.let("paramsErrors",s._`[]`);h((t=>{n.if(e,(()=>n.code(s._`${e} += ${"string"==typeof c?c:";"}`))),n.code(s._`${e} += ${d(t)}`),n.assign(r,s._`${r}.concat(${i}[${t}])`)})),a.reportError(t,{message:e,params:s._`{errors: ${r}}`})}else h((e=>a.reportError(t,{message:d(e),params:s._`{errors: ${i}[${e}]}`})));function h(e){n.forIn("key",i,(t=>n.if(s._`${i}[${t}].length`,(()=>e(t)))))}function d(e){return s._`${e} in ${o} ? ${o}[${e}]() : ${y}[${e}]`}}(o),i&&function(e){const r=n.const("emErrors",s.stringify(e)),i=[];for(const t in e)i.push([t,A(e[t],g[t])]);const o=n.const("templates",n.object(...i)),c=n.scopeValue("obj",{ref:h,code:s.stringify(h)}),d=n.let("emPropParams"),m=n.let("emParamsErrors");n.forOf("err",l.default.vErrors,(e=>n.if(C(e,r),(()=>{n.assign(d,s._`${c}[${e}.keyword]`),n.assign(m,s._`${r}[${e}.keyword][${e}.params[${d}]]`),n.if(m,(()=>n.code(s._`${m}.push(${e})`).assign(s._`${e}.${u}`,!0)))})))),n.forIn("key",r,(e=>n.forIn("keyProp",s._`${r}[${e}]`,(i=>{n.assign(m,s._`${r}[${e}][${i}]`),n.if(s._`${m}.length`,(()=>{const r=n.const("tmpl",s._`${o}[${e}] && ${o}[${e}][${i}]`);a.reportError(t,{message:s._`${r} ? ${r}() : ${y}[${e}][${i}]`,params:s._`{errors: ${m}}`})}))}))))}(i),function(e){const{props:i,items:o}=e;if(!i&&!o)return;const h=s._`typeof ${f} == "object"`,d=s._`Array.isArray(${f})`,m=n.let("emErrors");let p,b;const v=n.let("templates");function C(e,t){n.assign(m,s.stringify(e)),n.assign(v,A(e,t))}i&&o?(p=n.let("emChildKwd"),n.if(h),n.if(d,(()=>{C(o,g.items),n.assign(p,s.str`items`)}),(()=>{C(i,g.properties),n.assign(p,s.str`properties`)})),b=s._`[${p}]`):o?(n.if(d),C(o,g.items),b=s._`.items`):i&&(n.if(r.and(h,r.not(d))),C(i,g.properties),b=s._`.properties`),n.forOf("err",l.default.vErrors,(e=>function(e,t,i){n.if(r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,s._`${e}.instancePath.indexOf(${w}) === 0`),(()=>{const r=n.scopeValue("pattern",{ref:/^\/([^/]*)(?:\/|$)/,code:s._`new RegExp("^\\\/([^/]*)(?:\\\/|$)")`}),o=n.const("emMatches",s._`${r}.exec(${e}.instancePath.slice(${w}.length))`),a=n.const("emChild",s._`${o} && ${o}[1].replace(/~1/g, "/").replace(/~0/g, "~")`);n.if(s._`${a} !== undefined && ${a} in ${t}`,(()=>i(a)))}))}(e,m,(t=>n.code(s._`${m}[${t}].push(${e})`).assign(s._`${e}.${u}`,!0))))),n.forIn("key",m,(e=>n.if(s._`${m}[${e}].length`,(()=>{a.reportError(t,{message:s._`${e} in ${v} ? ${v}[${e}]() : ${y}${b}[${e}]`,params:s._`{errors: ${m}[${e}]}`}),n.assign(s._`${l.default.vErrors}[${l.default.errors}-1].instancePath`,s._`${w} + "/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`)})))),n.endIf()}(function({properties:e,items:t}){const n={};if(e){n.props={};for(const t in e)n.props[t]=[]}if(t){n.items={};for(let e=0;e<t.length;e++)n.items[e]=[]}return n}(v))}const i="string"==typeof v?v:v._;i&&function(e){const i=n.const("emErrs",s._`[]`);n.forOf("err",l.default.vErrors,(e=>n.if(function(e){return r.and(s._`${e}.keyword !== ${c}`,s._`!${e}.${u}`,r.or(s._`${e}.instancePath === ${w}`,r.and(s._`${e}.instancePath.indexOf(${w}) === 0`,s._`${e}.instancePath[${w}.length] === "/"`)),s._`${e}.schemaPath.indexOf(${b.errSchemaPath}) === 0`,s._`${e}.schemaPath[${b.errSchemaPath}.length] === "/"`)}(e),(()=>n.code(s._`${i}.push(${e})`).assign(s._`${e}.${u}`,!0))))),n.if(s._`${i}.length`,(()=>a.reportError(t,{message:S(e),params:s._`{errors: ${i}}`})))}(i),e.keepErrors||function(){const e=n.const("emErrs",s._`[]`);n.forOf("err",l.default.vErrors,(t=>n.if(s._`!${t}.${u}`,(()=>n.code(s._`${e}.push(${t})`))))),n.assign(l.default.vErrors,e).assign(l.default.errors,s._`${e}.length`)}()}))},metaSchema:{anyOf:[{type:"string"},{type:"object",properties:{properties:{$ref:"#/$defs/stringMap"},items:{$ref:"#/$defs/stringList"},required:{$ref:"#/$defs/stringOrMap"},dependencies:{$ref:"#/$defs/stringOrMap"}},additionalProperties:{type:"string"}}],$defs:{stringMap:{type:"object",additionalProperties:{type:"string"}},stringOrMap:{anyOf:[{type:"string"},{$ref:"#/$defs/stringMap"}]},stringList:{type:"array",items:{type:"string"}}}}}}(t))};t.default=f,e.exports=f,e.exports.default=f},5128:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;const s=n(7159),r=n(7299),i=n(1240),o=n(4087),a="https://json-schema.org/draft/2020-12/schema";class l extends s.default{constructor(e={}){super({...e,dynamicRef:!0,next:!0,unevaluated:!0})}_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(i.default)}_addDefaultMetaSchema(){super._addDefaultMetaSchema();const{$data:e,meta:t}=this.opts;t&&(o.default.call(this,e),this.refs["http://json-schema.org/schema"]=a)}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(a)?a:void 0)}}e.exports=t=l,Object.defineProperty(t,"__esModule",{value:!0}),t.default=l;var c=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return c.KeywordCxt}});var u=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return u._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return u.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return u.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return u.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return u.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return u.CodeGen}});var h=n(7426);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return h.default}});var d=n(6646);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return d.default}})},1581:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.MissingRefError=t.ValidationError=t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;const s=n(7159),r=n(3924),i=n(1240),o=n(98),a=["/properties"],l="http://json-schema.org/draft-07/schema";class c extends s.default{_addVocabularies(){super._addVocabularies(),r.default.forEach((e=>this.addVocabulary(e))),this.opts.discriminator&&this.addKeyword(i.default)}_addDefaultMetaSchema(){if(super._addDefaultMetaSchema(),!this.opts.meta)return;const e=this.opts.$data?this.$dataMetaSchema(o,a):o;this.addMetaSchema(e,l,!1),this.refs["http://json-schema.org/schema"]=l}defaultMeta(){return this.opts.defaultMeta=super.defaultMeta()||(this.getSchema(l)?l:void 0)}}e.exports=t=c,Object.defineProperty(t,"__esModule",{value:!0}),t.default=c;var u=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return u.KeywordCxt}});var h=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return h._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return h.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return h.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return h.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return h.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return h.CodeGen}});var d=n(7426);Object.defineProperty(t,"ValidationError",{enumerable:!0,get:function(){return d.default}});var m=n(6646);Object.defineProperty(t,"MissingRefError",{enumerable:!0,get:function(){return m.default}})},7023:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.regexpCode=t.getEsmExportName=t.getProperty=t.safeStringify=t.stringify=t.strConcat=t.addCodeArg=t.str=t._=t.nil=t._Code=t.Name=t.IDENTIFIER=t._CodeOrName=void 0;class n{}t._CodeOrName=n,t.IDENTIFIER=/^[a-z$_][a-z$_0-9]*$/i;class s extends n{constructor(e){if(super(),!t.IDENTIFIER.test(e))throw new Error("CodeGen: name must be a valid identifier");this.str=e}toString(){return this.str}emptyStr(){return!1}get names(){return{[this.str]:1}}}t.Name=s;class r extends n{constructor(e){super(),this._items="string"==typeof e?[e]:e}toString(){return this.str}emptyStr(){if(this._items.length>1)return!1;const e=this._items[0];return""===e||'""'===e}get str(){var e;return null!==(e=this._str)&&void 0!==e?e:this._str=this._items.reduce(((e,t)=>`${e}${t}`),"")}get names(){var e;return null!==(e=this._names)&&void 0!==e?e:this._names=this._items.reduce(((e,t)=>(t instanceof s&&(e[t.str]=(e[t.str]||0)+1),e)),{})}}function i(e,...t){const n=[e[0]];let s=0;for(;s<t.length;)l(n,t[s]),n.push(e[++s]);return new r(n)}t._Code=r,t.nil=new r(""),t._=i;const o=new r("+");function a(e,...t){const n=[u(e[0])];let s=0;for(;s<t.length;)n.push(o),l(n,t[s]),n.push(o,u(e[++s]));return function(e){let t=1;for(;t<e.length-1;){if(e[t]===o){const n=c(e[t-1],e[t+1]);if(void 0!==n){e.splice(t-1,3,n);continue}e[t++]="+"}t++}}(n),new r(n)}function l(e,t){var n;t instanceof r?e.push(...t._items):t instanceof s?e.push(t):e.push("number"==typeof(n=t)||"boolean"==typeof n||null===n?n:u(Array.isArray(n)?n.join(","):n))}function c(e,t){if('""'===t)return e;if('""'===e)return t;if("string"==typeof e){if(t instanceof s||'"'!==e[e.length-1])return;return"string"!=typeof t?`${e.slice(0,-1)}${t}"`:'"'===t[0]?e.slice(0,-1)+t.slice(1):void 0}return"string"!=typeof t||'"'!==t[0]||e instanceof s?void 0:`"${e}${t.slice(1)}`}function u(e){return JSON.stringify(e).replace(/\u2028/g,"\\u2028").replace(/\u2029/g,"\\u2029")}t.str=a,t.addCodeArg=l,t.strConcat=function(e,t){return t.emptyStr()?e:e.emptyStr()?t:a`${e}${t}`},t.stringify=function(e){return new r(u(e))},t.safeStringify=u,t.getProperty=function(e){return"string"==typeof e&&t.IDENTIFIER.test(e)?new r(`.${e}`):i`[${e}]`},t.getEsmExportName=function(e){if("string"==typeof e&&t.IDENTIFIER.test(e))return new r(`${e}`);throw new Error(`CodeGen: invalid export name: ${e}, use explicit $id name mapping`)},t.regexpCode=function(e){return new r(e.toString())}},3487:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.or=t.and=t.not=t.CodeGen=t.operators=t.varKinds=t.ValueScopeName=t.ValueScope=t.Scope=t.Name=t.regexpCode=t.stringify=t.getProperty=t.nil=t.strConcat=t.str=t._=void 0;const s=n(7023),r=n(8490);var i=n(7023);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return i._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return i.str}}),Object.defineProperty(t,"strConcat",{enumerable:!0,get:function(){return i.strConcat}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return i.nil}}),Object.defineProperty(t,"getProperty",{enumerable:!0,get:function(){return i.getProperty}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return i.stringify}}),Object.defineProperty(t,"regexpCode",{enumerable:!0,get:function(){return i.regexpCode}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return i.Name}});var o=n(8490);Object.defineProperty(t,"Scope",{enumerable:!0,get:function(){return o.Scope}}),Object.defineProperty(t,"ValueScope",{enumerable:!0,get:function(){return o.ValueScope}}),Object.defineProperty(t,"ValueScopeName",{enumerable:!0,get:function(){return o.ValueScopeName}}),Object.defineProperty(t,"varKinds",{enumerable:!0,get:function(){return o.varKinds}}),t.operators={GT:new s._Code(">"),GTE:new s._Code(">="),LT:new s._Code("<"),LTE:new s._Code("<="),EQ:new s._Code("==="),NEQ:new s._Code("!=="),NOT:new s._Code("!"),OR:new s._Code("||"),AND:new s._Code("&&"),ADD:new s._Code("+")};class a{optimizeNodes(){return this}optimizeNames(e,t){return this}}class l extends a{constructor(e,t,n){super(),this.varKind=e,this.name=t,this.rhs=n}render({es5:e,_n:t}){const n=e?r.varKinds.var:this.varKind,s=void 0===this.rhs?"":` = ${this.rhs}`;return`${n} ${this.name}${s};`+t}optimizeNames(e,t){if(e[this.name.str])return this.rhs&&(this.rhs=$(this.rhs,e,t)),this}get names(){return this.rhs instanceof s._CodeOrName?this.rhs.names:{}}}class c extends a{constructor(e,t,n){super(),this.lhs=e,this.rhs=t,this.sideEffects=n}render({_n:e}){return`${this.lhs} = ${this.rhs};`+e}optimizeNames(e,t){if(!(this.lhs instanceof s.Name)||e[this.lhs.str]||this.sideEffects)return this.rhs=$(this.rhs,e,t),this}get names(){return N(this.lhs instanceof s.Name?{}:{...this.lhs.names},this.rhs)}}class u extends c{constructor(e,t,n,s){super(e,n,s),this.op=t}render({_n:e}){return`${this.lhs} ${this.op}= ${this.rhs};`+e}}class h extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`${this.label}:`+e}}class d extends a{constructor(e){super(),this.label=e,this.names={}}render({_n:e}){return`break${this.label?` ${this.label}`:""};`+e}}class m extends a{constructor(e){super(),this.error=e}render({_n:e}){return`throw ${this.error};`+e}get names(){return this.error.names}}class p extends a{constructor(e){super(),this.code=e}render({_n:e}){return`${this.code};`+e}optimizeNodes(){return`${this.code}`?this:void 0}optimizeNames(e,t){return this.code=$(this.code,e,t),this}get names(){return this.code instanceof s._CodeOrName?this.code.names:{}}}class f extends a{constructor(e=[]){super(),this.nodes=e}render(e){return this.nodes.reduce(((t,n)=>t+n.render(e)),"")}optimizeNodes(){const{nodes:e}=this;let t=e.length;for(;t--;){const n=e[t].optimizeNodes();Array.isArray(n)?e.splice(t,1,...n):n?e[t]=n:e.splice(t,1)}return e.length>0?this:void 0}optimizeNames(e,t){const{nodes:n}=this;let s=n.length;for(;s--;){const r=n[s];r.optimizeNames(e,t)||(L(e,r.names),n.splice(s,1))}return n.length>0?this:void 0}get names(){return this.nodes.reduce(((e,t)=>M(e,t.names)),{})}}class g extends f{render(e){return"{"+e._n+super.render(e)+"}"+e._n}}class y extends f{}class b extends g{}b.kind="else";class v extends g{constructor(e,t){super(t),this.condition=e}render(e){let t=`if(${this.condition})`+super.render(e);return this.else&&(t+="else "+this.else.render(e)),t}optimizeNodes(){super.optimizeNodes();const e=this.condition;if(!0===e)return this.nodes;let t=this.else;if(t){const e=t.optimizeNodes();t=this.else=Array.isArray(e)?new b(e):e}return t?!1===e?t instanceof v?t:t.nodes:this.nodes.length?this:new v(P(e),t instanceof v?[t]:t.nodes):!1!==e&&this.nodes.length?this:void 0}optimizeNames(e,t){var n;if(this.else=null===(n=this.else)||void 0===n?void 0:n.optimizeNames(e,t),super.optimizeNames(e,t)||this.else)return this.condition=$(this.condition,e,t),this}get names(){const e=super.names;return N(e,this.condition),this.else&&M(e,this.else.names),e}}v.kind="if";class w extends g{}w.kind="for";class C extends w{constructor(e){super(),this.iteration=e}render(e){return`for(${this.iteration})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iteration=$(this.iteration,e,t),this}get names(){return M(super.names,this.iteration.names)}}class A extends w{constructor(e,t,n,s){super(),this.varKind=e,this.name=t,this.from=n,this.to=s}render(e){const t=e.es5?r.varKinds.var:this.varKind,{name:n,from:s,to:i}=this;return`for(${t} ${n}=${s}; ${n}<${i}; ${n}++)`+super.render(e)}get names(){const e=N(super.names,this.from);return N(e,this.to)}}class S extends w{constructor(e,t,n,s){super(),this.loop=e,this.varKind=t,this.name=n,this.iterable=s}render(e){return`for(${this.varKind} ${this.name} ${this.loop} ${this.iterable})`+super.render(e)}optimizeNames(e,t){if(super.optimizeNames(e,t))return this.iterable=$(this.iterable,e,t),this}get names(){return M(super.names,this.iterable.names)}}class x extends g{constructor(e,t,n){super(),this.name=e,this.args=t,this.async=n}render(e){return`${this.async?"async ":""}function ${this.name}(${this.args})`+super.render(e)}}x.kind="func";class E extends f{render(e){return"return "+super.render(e)}}E.kind="return";class T extends g{render(e){let t="try"+super.render(e);return this.catch&&(t+=this.catch.render(e)),this.finally&&(t+=this.finally.render(e)),t}optimizeNodes(){var e,t;return super.optimizeNodes(),null===(e=this.catch)||void 0===e||e.optimizeNodes(),null===(t=this.finally)||void 0===t||t.optimizeNodes(),this}optimizeNames(e,t){var n,s;return super.optimizeNames(e,t),null===(n=this.catch)||void 0===n||n.optimizeNames(e,t),null===(s=this.finally)||void 0===s||s.optimizeNames(e,t),this}get names(){const e=super.names;return this.catch&&M(e,this.catch.names),this.finally&&M(e,this.finally.names),e}}class _ extends g{constructor(e){super(),this.error=e}render(e){return`catch(${this.error})`+super.render(e)}}_.kind="catch";class I extends g{render(e){return"finally"+super.render(e)}}function M(e,t){for(const n in t)e[n]=(e[n]||0)+(t[n]||0);return e}function N(e,t){return t instanceof s._CodeOrName?M(e,t.names):e}function $(e,t,n){return e instanceof s.Name?i(e):(r=e)instanceof s._Code&&r._items.some((e=>e instanceof s.Name&&1===t[e.str]&&void 0!==n[e.str]))?new s._Code(e._items.reduce(((e,t)=>(t instanceof s.Name&&(t=i(t)),t instanceof s._Code?e.push(...t._items):e.push(t),e)),[])):e;var r;function i(e){const s=n[e.str];return void 0===s||1!==t[e.str]?e:(delete t[e.str],s)}}function L(e,t){for(const n in t)e[n]=(e[n]||0)-(t[n]||0)}function P(e){return"boolean"==typeof e||"number"==typeof e||null===e?!e:s._`!${D(e)}`}I.kind="finally",t.CodeGen=class{constructor(e,t={}){this._values={},this._blockStarts=[],this._constants={},this.opts={...t,_n:t.lines?"\n":""},this._extScope=e,this._scope=new r.Scope({parent:e}),this._nodes=[new y]}toString(){return this._root.render(this.opts)}name(e){return this._scope.name(e)}scopeName(e){return this._extScope.name(e)}scopeValue(e,t){const n=this._extScope.value(e,t);return(this._values[n.prefix]||(this._values[n.prefix]=new Set)).add(n),n}getScopeValue(e,t){return this._extScope.getValue(e,t)}scopeRefs(e){return this._extScope.scopeRefs(e,this._values)}scopeCode(){return this._extScope.scopeCode(this._values)}_def(e,t,n,s){const r=this._scope.toName(t);return void 0!==n&&s&&(this._constants[r.str]=n),this._leafNode(new l(e,r,n)),r}const(e,t,n){return this._def(r.varKinds.const,e,t,n)}let(e,t,n){return this._def(r.varKinds.let,e,t,n)}var(e,t,n){return this._def(r.varKinds.var,e,t,n)}assign(e,t,n){return this._leafNode(new c(e,t,n))}add(e,n){return this._leafNode(new u(e,t.operators.ADD,n))}code(e){return"function"==typeof e?e():e!==s.nil&&this._leafNode(new p(e)),this}object(...e){const t=["{"];for(const[n,r]of e)t.length>1&&t.push(","),t.push(n),(n!==r||this.opts.es5)&&(t.push(":"),(0,s.addCodeArg)(t,r));return t.push("}"),new s._Code(t)}if(e,t,n){if(this._blockNode(new v(e)),t&&n)this.code(t).else().code(n).endIf();else if(t)this.code(t).endIf();else if(n)throw new Error('CodeGen: "else" body without "then" body');return this}elseIf(e){return this._elseNode(new v(e))}else(){return this._elseNode(new b)}endIf(){return this._endBlockNode(v,b)}_for(e,t){return this._blockNode(e),t&&this.code(t).endFor(),this}for(e,t){return this._for(new C(e),t)}forRange(e,t,n,s,i=(this.opts.es5?r.varKinds.var:r.varKinds.let)){const o=this._scope.toName(e);return this._for(new A(i,o,t,n),(()=>s(o)))}forOf(e,t,n,i=r.varKinds.const){const o=this._scope.toName(e);if(this.opts.es5){const e=t instanceof s.Name?t:this.var("_arr",t);return this.forRange("_i",0,s._`${e}.length`,(t=>{this.var(o,s._`${e}[${t}]`),n(o)}))}return this._for(new S("of",i,o,t),(()=>n(o)))}forIn(e,t,n,i=(this.opts.es5?r.varKinds.var:r.varKinds.const)){if(this.opts.ownProperties)return this.forOf(e,s._`Object.keys(${t})`,n);const o=this._scope.toName(e);return this._for(new S("in",i,o,t),(()=>n(o)))}endFor(){return this._endBlockNode(w)}label(e){return this._leafNode(new h(e))}break(e){return this._leafNode(new d(e))}return(e){const t=new E;if(this._blockNode(t),this.code(e),1!==t.nodes.length)throw new Error('CodeGen: "return" should have one node');return this._endBlockNode(E)}try(e,t,n){if(!t&&!n)throw new Error('CodeGen: "try" without "catch" and "finally"');const s=new T;if(this._blockNode(s),this.code(e),t){const e=this.name("e");this._currNode=s.catch=new _(e),t(e)}return n&&(this._currNode=s.finally=new I,this.code(n)),this._endBlockNode(_,I)}throw(e){return this._leafNode(new m(e))}block(e,t){return this._blockStarts.push(this._nodes.length),e&&this.code(e).endBlock(t),this}endBlock(e){const t=this._blockStarts.pop();if(void 0===t)throw new Error("CodeGen: not in self-balancing block");const n=this._nodes.length-t;if(n<0||void 0!==e&&n!==e)throw new Error(`CodeGen: wrong number of nodes: ${n} vs ${e} expected`);return this._nodes.length=t,this}func(e,t=s.nil,n,r){return this._blockNode(new x(e,t,n)),r&&this.code(r).endFunc(),this}endFunc(){return this._endBlockNode(x)}optimize(e=1){for(;e-- >0;)this._root.optimizeNodes(),this._root.optimizeNames(this._root.names,this._constants)}_leafNode(e){return this._currNode.nodes.push(e),this}_blockNode(e){this._currNode.nodes.push(e),this._nodes.push(e)}_endBlockNode(e,t){const n=this._currNode;if(n instanceof e||t&&n instanceof t)return this._nodes.pop(),this;throw new Error(`CodeGen: not in block "${t?`${e.kind}/${t.kind}`:e.kind}"`)}_elseNode(e){const t=this._currNode;if(!(t instanceof v))throw new Error('CodeGen: "else" without "if"');return this._currNode=t.else=e,this}get _root(){return this._nodes[0]}get _currNode(){const e=this._nodes;return e[e.length-1]}set _currNode(e){const t=this._nodes;t[t.length-1]=e}},t.not=P;const R=k(t.operators.AND);t.and=function(...e){return e.reduce(R)};const O=k(t.operators.OR);function k(e){return(t,n)=>t===s.nil?n:n===s.nil?t:s._`${D(t)} ${e} ${D(n)}`}function D(e){return e instanceof s.Name?e:s._`(${e})`}t.or=function(...e){return e.reduce(O)}},8490:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.ValueScope=t.ValueScopeName=t.Scope=t.varKinds=t.UsedValueState=void 0;const s=n(7023);class r extends Error{constructor(e){super(`CodeGen: "code" for ${e} not defined`),this.value=e.value}}var i;!function(e){e[e.Started=0]="Started",e[e.Completed=1]="Completed"}(i=t.UsedValueState||(t.UsedValueState={})),t.varKinds={const:new s.Name("const"),let:new s.Name("let"),var:new s.Name("var")};class o{constructor({prefixes:e,parent:t}={}){this._names={},this._prefixes=e,this._parent=t}toName(e){return e instanceof s.Name?e:this.name(e)}name(e){return new s.Name(this._newName(e))}_newName(e){return`${e}${(this._names[e]||this._nameGroup(e)).index++}`}_nameGroup(e){var t,n;if((null===(n=null===(t=this._parent)||void 0===t?void 0:t._prefixes)||void 0===n?void 0:n.has(e))||this._prefixes&&!this._prefixes.has(e))throw new Error(`CodeGen: prefix "${e}" is not allowed in this scope`);return this._names[e]={prefix:e,index:0}}}t.Scope=o;class a extends s.Name{constructor(e,t){super(t),this.prefix=e}setValue(e,{property:t,itemIndex:n}){this.value=e,this.scopePath=s._`.${new s.Name(t)}[${n}]`}}t.ValueScopeName=a;const l=s._`\n`;t.ValueScope=class extends o{constructor(e){super(e),this._values={},this._scope=e.scope,this.opts={...e,_n:e.lines?l:s.nil}}get(){return this._scope}name(e){return new a(e,this._newName(e))}value(e,t){var n;if(void 0===t.ref)throw new Error("CodeGen: ref must be passed in value");const s=this.toName(e),{prefix:r}=s,i=null!==(n=t.key)&&void 0!==n?n:t.ref;let o=this._values[r];if(o){const e=o.get(i);if(e)return e}else o=this._values[r]=new Map;o.set(i,s);const a=this._scope[r]||(this._scope[r]=[]),l=a.length;return a[l]=t.ref,s.setValue(t,{property:r,itemIndex:l}),s}getValue(e,t){const n=this._values[e];if(n)return n.get(t)}scopeRefs(e,t=this._values){return this._reduceValues(t,(t=>{if(void 0===t.scopePath)throw new Error(`CodeGen: name "${t}" has no value`);return s._`${e}${t.scopePath}`}))}scopeCode(e=this._values,t,n){return this._reduceValues(e,(e=>{if(void 0===e.value)throw new Error(`CodeGen: name "${e}" has no value`);return e.value.code}),t,n)}_reduceValues(e,n,o={},a){let l=s.nil;for(const c in e){const u=e[c];if(!u)continue;const h=o[c]=o[c]||new Map;u.forEach((e=>{if(h.has(e))return;h.set(e,i.Started);let o=n(e);if(o){const n=this.opts.es5?t.varKinds.var:t.varKinds.const;l=s._`${l}${n} ${e} = ${o};${this.opts._n}`}else{if(!(o=null==a?void 0:a(e)))throw new r(e);l=s._`${l}${o}${this.opts._n}`}h.set(e,i.Completed)}))}return l}}},4181:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendErrors=t.resetErrorsCount=t.reportExtraError=t.reportError=t.keyword$DataError=t.keywordError=void 0;const s=n(3487),r=n(6776),i=n(2141);function o(e,t){const n=e.const("err",t);e.if(s._`${i.default.vErrors} === null`,(()=>e.assign(i.default.vErrors,s._`[${n}]`)),s._`${i.default.vErrors}.push(${n})`),e.code(s._`${i.default.errors}++`)}function a(e,t){const{gen:n,validateName:r,schemaEnv:i}=e;i.$async?n.throw(s._`new ${e.ValidationError}(${t})`):(n.assign(s._`${r}.errors`,t),n.return(!1))}t.keywordError={message:({keyword:e})=>s.str`must pass "${e}" keyword validation`},t.keyword$DataError={message:({keyword:e,schemaType:t})=>t?s.str`"${e}" keyword must be ${t} ($data)`:s.str`"${e}" keyword is invalid ($data)`},t.reportError=function(e,n=t.keywordError,r,i){const{it:l}=e,{gen:u,compositeRule:h,allErrors:d}=l,m=c(e,n,r);(null!=i?i:h||d)?o(u,m):a(l,s._`[${m}]`)},t.reportExtraError=function(e,n=t.keywordError,s){const{it:r}=e,{gen:l,compositeRule:u,allErrors:h}=r;o(l,c(e,n,s)),u||h||a(r,i.default.vErrors)},t.resetErrorsCount=function(e,t){e.assign(i.default.errors,t),e.if(s._`${i.default.vErrors} !== null`,(()=>e.if(t,(()=>e.assign(s._`${i.default.vErrors}.length`,t)),(()=>e.assign(i.default.vErrors,null)))))},t.extendErrors=function({gen:e,keyword:t,schemaValue:n,data:r,errsCount:o,it:a}){if(void 0===o)throw new Error("ajv implementation error");const l=e.name("err");e.forRange("i",o,i.default.errors,(o=>{e.const(l,s._`${i.default.vErrors}[${o}]`),e.if(s._`${l}.instancePath === undefined`,(()=>e.assign(s._`${l}.instancePath`,(0,s.strConcat)(i.default.instancePath,a.errorPath)))),e.assign(s._`${l}.schemaPath`,s.str`${a.errSchemaPath}/${t}`),a.opts.verbose&&(e.assign(s._`${l}.schema`,n),e.assign(s._`${l}.data`,r))}))};const l={keyword:new s.Name("keyword"),schemaPath:new s.Name("schemaPath"),params:new s.Name("params"),propertyName:new s.Name("propertyName"),message:new s.Name("message"),schema:new s.Name("schema"),parentSchema:new s.Name("parentSchema")};function c(e,t,n){const{createErrors:r}=e.it;return!1===r?s._`{}`:function(e,t,n={}){const{gen:r,it:o}=e,a=[u(o,n),h(e,n)];return function(e,{params:t,message:n},r){const{keyword:o,data:a,schemaValue:c,it:u}=e,{opts:h,propertyName:d,topSchemaRef:m,schemaPath:p}=u;r.push([l.keyword,o],[l.params,"function"==typeof t?t(e):t||s._`{}`]),h.messages&&r.push([l.message,"function"==typeof n?n(e):n]),h.verbose&&r.push([l.schema,c],[l.parentSchema,s._`${m}${p}`],[i.default.data,a]),d&&r.push([l.propertyName,d])}(e,t,a),r.object(...a)}(e,t,n)}function u({errorPath:e},{instancePath:t}){const n=t?s.str`${e}${(0,r.getErrorPath)(t,r.Type.Str)}`:e;return[i.default.instancePath,(0,s.strConcat)(i.default.instancePath,n)]}function h({keyword:e,it:{errSchemaPath:t}},{schemaPath:n,parentSchema:i}){let o=i?t:s.str`${t}/${e}`;return n&&(o=s.str`${o}${(0,r.getErrorPath)(n,r.Type.Str)}`),[l.schemaPath,o]}},5173:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.resolveSchema=t.getCompilingSchema=t.resolveRef=t.compileSchema=t.SchemaEnv=void 0;const s=n(3487),r=n(7426),i=n(2141),o=n(2531),a=n(6776),l=n(4815);class c{constructor(e){var t;let n;this.refs={},this.dynamicAnchors={},"object"==typeof e.schema&&(n=e.schema),this.schema=e.schema,this.schemaId=e.schemaId,this.root=e.root||this,this.baseId=null!==(t=e.baseId)&&void 0!==t?t:(0,o.normalizeId)(null==n?void 0:n[e.schemaId||"$id"]),this.schemaPath=e.schemaPath,this.localRefs=e.localRefs,this.meta=e.meta,this.$async=null==n?void 0:n.$async,this.refs={}}}function u(e){const t=d.call(this,e);if(t)return t;const n=(0,o.getFullPath)(this.opts.uriResolver,e.root.baseId),{es5:a,lines:c}=this.opts.code,{ownProperties:u}=this.opts,h=new s.CodeGen(this.scope,{es5:a,lines:c,ownProperties:u});let m;e.$async&&(m=h.scopeValue("Error",{ref:r.default,code:s._`require("ajv/dist/runtime/validation_error").default`}));const p=h.scopeName("validate");e.validateName=p;const f={gen:h,allErrors:this.opts.allErrors,data:i.default.data,parentData:i.default.parentData,parentDataProperty:i.default.parentDataProperty,dataNames:[i.default.data],dataPathArr:[s.nil],dataLevel:0,dataTypes:[],definedProperties:new Set,topSchemaRef:h.scopeValue("schema",!0===this.opts.code.source?{ref:e.schema,code:(0,s.stringify)(e.schema)}:{ref:e.schema}),validateName:p,ValidationError:m,schema:e.schema,schemaEnv:e,rootId:n,baseId:e.baseId||n,schemaPath:s.nil,errSchemaPath:e.schemaPath||(this.opts.jtd?"":"#"),errorPath:s._`""`,opts:this.opts,self:this};let g;try{this._compilations.add(e),(0,l.validateFunctionCode)(f),h.optimize(this.opts.code.optimize);const t=h.toString();g=`${h.scopeRefs(i.default.scope)}return ${t}`,this.opts.code.process&&(g=this.opts.code.process(g,e));const n=new Function(`${i.default.self}`,`${i.default.scope}`,g)(this,this.scope.get());if(this.scope.value(p,{ref:n}),n.errors=null,n.schema=e.schema,n.schemaEnv=e,e.$async&&(n.$async=!0),!0===this.opts.code.source&&(n.source={validateName:p,validateCode:t,scopeValues:h._values}),this.opts.unevaluated){const{props:e,items:t}=f;n.evaluated={props:e instanceof s.Name?void 0:e,items:t instanceof s.Name?void 0:t,dynamicProps:e instanceof s.Name,dynamicItems:t instanceof s.Name},n.source&&(n.source.evaluated=(0,s.stringify)(n.evaluated))}return e.validate=n,e}catch(t){throw delete e.validate,delete e.validateName,g&&this.logger.error("Error compiling schema, function code:",g),t}finally{this._compilations.delete(e)}}function h(e){return(0,o.inlineRef)(e.schema,this.opts.inlineRefs)?e.schema:e.validate?e:u.call(this,e)}function d(e){for(const s of this._compilations)if(n=e,(t=s).schema===n.schema&&t.root===n.root&&t.baseId===n.baseId)return s;var t,n}function m(e,t){let n;for(;"string"==typeof(n=this.refs[t]);)t=n;return n||this.schemas[t]||p.call(this,e,t)}function p(e,t){const n=this.opts.uriResolver.parse(t),s=(0,o._getFullPath)(this.opts.uriResolver,n);let r=(0,o.getFullPath)(this.opts.uriResolver,e.baseId,void 0);if(Object.keys(e.schema).length>0&&s===r)return g.call(this,n,e);const i=(0,o.normalizeId)(s),a=this.refs[i]||this.schemas[i];if("string"==typeof a){const t=p.call(this,e,a);if("object"!=typeof(null==t?void 0:t.schema))return;return g.call(this,n,t)}if("object"==typeof(null==a?void 0:a.schema)){if(a.validate||u.call(this,a),i===(0,o.normalizeId)(t)){const{schema:t}=a,{schemaId:n}=this.opts,s=t[n];return s&&(r=(0,o.resolveUrl)(this.opts.uriResolver,r,s)),new c({schema:t,schemaId:n,root:e,baseId:r})}return g.call(this,n,a)}}t.SchemaEnv=c,t.compileSchema=u,t.resolveRef=function(e,t,n){var s;n=(0,o.resolveUrl)(this.opts.uriResolver,t,n);const r=e.refs[n];if(r)return r;let i=m.call(this,e,n);if(void 0===i){const r=null===(s=e.localRefs)||void 0===s?void 0:s[n],{schemaId:o}=this.opts;r&&(i=new c({schema:r,schemaId:o,root:e,baseId:t}))}return void 0!==i?e.refs[n]=h.call(this,i):void 0},t.getCompilingSchema=d,t.resolveSchema=p;const f=new Set(["properties","patternProperties","enum","dependencies","definitions"]);function g(e,{baseId:t,schema:n,root:s}){var r;if("/"!==(null===(r=e.fragment)||void 0===r?void 0:r[0]))return;for(const s of e.fragment.slice(1).split("/")){if("boolean"==typeof n)return;const e=n[(0,a.unescapeFragment)(s)];if(void 0===e)return;const r="object"==typeof(n=e)&&n[this.opts.schemaId];!f.has(s)&&r&&(t=(0,o.resolveUrl)(this.opts.uriResolver,t,r))}let i;if("boolean"!=typeof n&&n.$ref&&!(0,a.schemaHasRulesButRef)(n,this.RULES)){const e=(0,o.resolveUrl)(this.opts.uriResolver,t,n.$ref);i=p.call(this,s,e)}const{schemaId:l}=this.opts;return i=i||new c({schema:n,schemaId:l,root:s,baseId:t}),i.schema!==i.root.schema?i:void 0}},2141:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={data:new s.Name("data"),valCxt:new s.Name("valCxt"),instancePath:new s.Name("instancePath"),parentData:new s.Name("parentData"),parentDataProperty:new s.Name("parentDataProperty"),rootData:new s.Name("rootData"),dynamicAnchors:new s.Name("dynamicAnchors"),vErrors:new s.Name("vErrors"),errors:new s.Name("errors"),this:new s.Name("this"),self:new s.Name("self"),scope:new s.Name("scope"),json:new s.Name("json"),jsonPos:new s.Name("jsonPos"),jsonLen:new s.Name("jsonLen"),jsonPart:new s.Name("jsonPart")};t.default=r},6646:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(2531);class r extends Error{constructor(e,t,n,r){super(r||`can't resolve reference ${n} from id ${t}`),this.missingRef=(0,s.resolveUrl)(e,t,n),this.missingSchema=(0,s.normalizeId)((0,s.getFullPath)(e,this.missingRef))}}t.default=r},2531:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getSchemaRefs=t.resolveUrl=t.normalizeId=t._getFullPath=t.getFullPath=t.inlineRef=void 0;const s=n(6776),r=n(4063),i=n(9461),o=new Set(["type","format","pattern","maxLength","minLength","maxProperties","minProperties","maxItems","minItems","maximum","minimum","uniqueItems","multipleOf","required","enum","const"]);t.inlineRef=function(e,t=!0){return"boolean"==typeof e||(!0===t?!l(e):!!t&&c(e)<=t)};const a=new Set(["$ref","$recursiveRef","$recursiveAnchor","$dynamicRef","$dynamicAnchor"]);function l(e){for(const t in e){if(a.has(t))return!0;const n=e[t];if(Array.isArray(n)&&n.some(l))return!0;if("object"==typeof n&&l(n))return!0}return!1}function c(e){let t=0;for(const n in e){if("$ref"===n)return 1/0;if(t++,!o.has(n)&&("object"==typeof e[n]&&(0,s.eachItem)(e[n],(e=>t+=c(e))),t===1/0))return 1/0}return t}function u(e,t="",n){!1!==n&&(t=m(t));const s=e.parse(t);return h(e,s)}function h(e,t){return e.serialize(t).split("#")[0]+"#"}t.getFullPath=u,t._getFullPath=h;const d=/#\/?$/;function m(e){return e?e.replace(d,""):""}t.normalizeId=m,t.resolveUrl=function(e,t,n){return n=m(n),e.resolve(t,n)};const p=/^[a-z_][-a-z0-9._]*$/i;t.getSchemaRefs=function(e,t){if("boolean"==typeof e)return{};const{schemaId:n,uriResolver:s}=this.opts,o=m(e[n]||t),a={"":o},l=u(s,o,!1),c={},h=new Set;return i(e,{allKeys:!0},((e,t,s,r)=>{if(void 0===r)return;const i=l+t;let o=a[r];function u(t){const n=this.opts.uriResolver.resolve;if(t=m(o?n(o,t):t),h.has(t))throw f(t);h.add(t);let s=this.refs[t];return"string"==typeof s&&(s=this.refs[s]),"object"==typeof s?d(e,s.schema,t):t!==m(i)&&("#"===t[0]?(d(e,c[t],t),c[t]=e):this.refs[t]=i),t}function g(e){if("string"==typeof e){if(!p.test(e))throw new Error(`invalid anchor "${e}"`);u.call(this,`#${e}`)}}"string"==typeof e[n]&&(o=u.call(this,e[n])),g.call(this,e.$anchor),g.call(this,e.$dynamicAnchor),a[t]=o})),c;function d(e,t,n){if(void 0!==t&&!r(e,t))throw f(n)}function f(e){return new Error(`reference "${e}" resolves to more than one schema`)}}},3141:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getRules=t.isJSONType=void 0;const n=new Set(["string","number","integer","boolean","null","object","array"]);t.isJSONType=function(e){return"string"==typeof e&&n.has(e)},t.getRules=function(){const e={number:{type:"number",rules:[]},string:{type:"string",rules:[]},array:{type:"array",rules:[]},object:{type:"object",rules:[]}};return{types:{...e,integer:!0,boolean:!0,null:!0},rules:[{rules:[]},e.number,e.string,e.array,e.object],post:{rules:[]},all:{},keywords:{}}}},6776:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.checkStrictMode=t.getErrorPath=t.Type=t.useFunc=t.setEvaluated=t.evaluatedPropsToName=t.mergeEvaluated=t.eachItem=t.unescapeJsonPointer=t.escapeJsonPointer=t.escapeFragment=t.unescapeFragment=t.schemaRefOrVal=t.schemaHasRulesButRef=t.schemaHasRules=t.checkUnknownRules=t.alwaysValidSchema=t.toHash=void 0;const s=n(3487),r=n(7023);function i(e,t=e.schema){const{opts:n,self:s}=e;if(!n.strictSchema)return;if("boolean"==typeof t)return;const r=s.RULES.keywords;for(const n in t)r[n]||p(e,`unknown keyword: "${n}"`)}function o(e,t){if("boolean"==typeof e)return!e;for(const n in e)if(t[n])return!0;return!1}function a(e){return"number"==typeof e?`${e}`:e.replace(/~/g,"~0").replace(/\//g,"~1")}function l(e){return e.replace(/~1/g,"/").replace(/~0/g,"~")}function c({mergeNames:e,mergeToName:t,mergeValues:n,resultToName:r}){return(i,o,a,l)=>{const c=void 0===a?o:a instanceof s.Name?(o instanceof s.Name?e(i,o,a):t(i,o,a),a):o instanceof s.Name?(t(i,a,o),o):n(o,a);return l!==s.Name||c instanceof s.Name?c:r(i,c)}}function u(e,t){if(!0===t)return e.var("props",!0);const n=e.var("props",s._`{}`);return void 0!==t&&h(e,n,t),n}function h(e,t,n){Object.keys(n).forEach((n=>e.assign(s._`${t}${(0,s.getProperty)(n)}`,!0)))}t.toHash=function(e){const t={};for(const n of e)t[n]=!0;return t},t.alwaysValidSchema=function(e,t){return"boolean"==typeof t?t:0===Object.keys(t).length||(i(e,t),!o(t,e.self.RULES.all))},t.checkUnknownRules=i,t.schemaHasRules=o,t.schemaHasRulesButRef=function(e,t){if("boolean"==typeof e)return!e;for(const n in e)if("$ref"!==n&&t.all[n])return!0;return!1},t.schemaRefOrVal=function({topSchemaRef:e,schemaPath:t},n,r,i){if(!i){if("number"==typeof n||"boolean"==typeof n)return n;if("string"==typeof n)return s._`${n}`}return s._`${e}${t}${(0,s.getProperty)(r)}`},t.unescapeFragment=function(e){return l(decodeURIComponent(e))},t.escapeFragment=function(e){return encodeURIComponent(a(e))},t.escapeJsonPointer=a,t.unescapeJsonPointer=l,t.eachItem=function(e,t){if(Array.isArray(e))for(const n of e)t(n);else t(e)},t.mergeEvaluated={props:c({mergeNames:(e,t,n)=>e.if(s._`${n} !== true && ${t} !== undefined`,(()=>{e.if(s._`${t} === true`,(()=>e.assign(n,!0)),(()=>e.assign(n,s._`${n} || {}`).code(s._`Object.assign(${n}, ${t})`)))})),mergeToName:(e,t,n)=>e.if(s._`${n} !== true`,(()=>{!0===t?e.assign(n,!0):(e.assign(n,s._`${n} || {}`),h(e,n,t))})),mergeValues:(e,t)=>!0===e||{...e,...t},resultToName:u}),items:c({mergeNames:(e,t,n)=>e.if(s._`${n} !== true && ${t} !== undefined`,(()=>e.assign(n,s._`${t} === true ? true : ${n} > ${t} ? ${n} : ${t}`))),mergeToName:(e,t,n)=>e.if(s._`${n} !== true`,(()=>e.assign(n,!0===t||s._`${n} > ${t} ? ${n} : ${t}`))),mergeValues:(e,t)=>!0===e||Math.max(e,t),resultToName:(e,t)=>e.var("items",t)})},t.evaluatedPropsToName=u,t.setEvaluated=h;const d={};var m;function p(e,t,n=e.opts.strictSchema){if(n){if(t=`strict mode: ${t}`,!0===n)throw new Error(t);e.self.logger.warn(t)}}t.useFunc=function(e,t){return e.scopeValue("func",{ref:t,code:d[t.code]||(d[t.code]=new r._Code(t.code))})},function(e){e[e.Num=0]="Num",e[e.Str=1]="Str"}(m=t.Type||(t.Type={})),t.getErrorPath=function(e,t,n){if(e instanceof s.Name){const r=t===m.Num;return n?r?s._`"[" + ${e} + "]"`:s._`"['" + ${e} + "']"`:r?s._`"/" + ${e}`:s._`"/" + ${e}.replace(/~/g, "~0").replace(/\\//g, "~1")`}return n?(0,s.getProperty)(e).toString():"/"+a(e)},t.checkStrictMode=p},8876:(e,t)=>{"use strict";function n(e,t){return t.rules.some((t=>s(e,t)))}function s(e,t){var n;return void 0!==e[t.keyword]||(null===(n=t.definition.implements)||void 0===n?void 0:n.some((t=>void 0!==e[t])))}Object.defineProperty(t,"__esModule",{value:!0}),t.shouldUseRule=t.shouldUseGroup=t.schemaHasRulesForType=void 0,t.schemaHasRulesForType=function({schema:e,self:t},s){const r=t.RULES.types[s];return r&&!0!==r&&n(e,r)},t.shouldUseGroup=n,t.shouldUseRule=s},5667:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.boolOrEmptySchema=t.topBoolOrEmptySchema=void 0;const s=n(4181),r=n(3487),i=n(2141),o={message:"boolean schema is false"};function a(e,t){const{gen:n,data:r}=e,i={gen:n,keyword:"false schema",data:r,schema:!1,schemaCode:!1,schemaValue:!1,params:{},it:e};(0,s.reportError)(i,o,void 0,t)}t.topBoolOrEmptySchema=function(e){const{gen:t,schema:n,validateName:s}=e;!1===n?a(e,!1):"object"==typeof n&&!0===n.$async?t.return(i.default.data):(t.assign(r._`${s}.errors`,null),t.return(!0))},t.boolOrEmptySchema=function(e,t){const{gen:n,schema:s}=e;!1===s?(n.var(t,!1),a(e)):n.var(t,!0)}},453:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.reportTypeError=t.checkDataTypes=t.checkDataType=t.coerceAndCheckDataType=t.getJSONTypes=t.getSchemaTypes=t.DataType=void 0;const s=n(3141),r=n(8876),i=n(4181),o=n(3487),a=n(6776);var l;function c(e){const t=Array.isArray(e)?e:e?[e]:[];if(t.every(s.isJSONType))return t;throw new Error("type must be JSONType or JSONType[]: "+t.join(","))}!function(e){e[e.Correct=0]="Correct",e[e.Wrong=1]="Wrong"}(l=t.DataType||(t.DataType={})),t.getSchemaTypes=function(e){const t=c(e.type);if(t.includes("null")){if(!1===e.nullable)throw new Error("type: null contradicts nullable: false")}else{if(!t.length&&void 0!==e.nullable)throw new Error('"nullable" cannot be used without "type"');!0===e.nullable&&t.push("null")}return t},t.getJSONTypes=c,t.coerceAndCheckDataType=function(e,t){const{gen:n,data:s,opts:i}=e,a=function(e,t){return t?e.filter((e=>u.has(e)||"array"===t&&"array"===e)):[]}(t,i.coerceTypes),c=t.length>0&&!(0===a.length&&1===t.length&&(0,r.schemaHasRulesForType)(e,t[0]));if(c){const r=d(t,s,i.strictNumbers,l.Wrong);n.if(r,(()=>{a.length?function(e,t,n){const{gen:s,data:r,opts:i}=e,a=s.let("dataType",o._`typeof ${r}`),l=s.let("coerced",o._`undefined`);"array"===i.coerceTypes&&s.if(o._`${a} == 'object' && Array.isArray(${r}) && ${r}.length == 1`,(()=>s.assign(r,o._`${r}[0]`).assign(a,o._`typeof ${r}`).if(d(t,r,i.strictNumbers),(()=>s.assign(l,r))))),s.if(o._`${l} !== undefined`);for(const e of n)(u.has(e)||"array"===e&&"array"===i.coerceTypes)&&c(e);function c(e){switch(e){case"string":return void s.elseIf(o._`${a} == "number" || ${a} == "boolean"`).assign(l,o._`"" + ${r}`).elseIf(o._`${r} === null`).assign(l,o._`""`);case"number":return void s.elseIf(o._`${a} == "boolean" || ${r} === null
3
3
  || (${a} == "string" && ${r} && ${r} == +${r})`).assign(l,o._`+${r}`);case"integer":return void s.elseIf(o._`${a} === "boolean" || ${r} === null
4
4
  || (${a} === "string" && ${r} && ${r} == +${r} && !(${r} % 1))`).assign(l,o._`+${r}`);case"boolean":return void s.elseIf(o._`${r} === "false" || ${r} === 0 || ${r} === null`).assign(l,!1).elseIf(o._`${r} === "true" || ${r} === 1`).assign(l,!0);case"null":return s.elseIf(o._`${r} === "" || ${r} === 0 || ${r} === false`),void s.assign(l,null);case"array":s.elseIf(o._`${a} === "string" || ${a} === "number"
5
- || ${a} === "boolean" || ${r} === null`).assign(l,o._`[${r}]`)}}s.else(),p(e),s.endIf(),s.if(o._`${l} !== undefined`,(()=>{s.assign(r,l),function({gen:e,parentData:t,parentDataProperty:n},s){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${n}]`,s)))}(e,l)}))}(e,t,a):p(e)}))}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,s=l.Correct){const r=s===l.Correct?o.operators.EQ:o.operators.NEQ;let i;switch(e){case"null":return o._`${t} ${r} null`;case"array":i=o._`Array.isArray(${t})`;break;case"object":i=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":i=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":i=a();break;default:return o._`typeof ${t} ${r} ${e}`}return s===l.Correct?i:(0,o.not)(i);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,n?o._`isFinite(${t})`:o.nil)}}function d(e,t,n,s){if(1===e.length)return h(e[0],t,n,s);let r;const i=(0,a.toHash)(e);if(i.array&&i.object){const e=o._`typeof ${t} != "object"`;r=i.null?e:o._`!${t} || ${e}`,delete i.null,delete i.array,delete i.object}else r=o.nil;i.number&&delete i.integer;for(const e in i)r=(0,o.and)(r,h(e,t,n,s));return r}t.checkDataType=h,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:n,schema:s}=e,r=(0,a.schemaRefOrVal)(e,s,"type");return{gen:t,keyword:"type",data:n,schema:s.type,schemaCode:r,schemaValue:r,parentSchema:s,params:{},it:e}}(e);(0,i.reportError)(t,m)}t.reportTypeError=p},313:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const s=n(3487),r=n(6776);function i(e,t,n){const{gen:i,compositeRule:o,data:a,opts:l}=e;if(void 0===n)return;const c=s._`${a}${(0,s.getProperty)(t)}`;if(o)return void(0,r.checkStrictMode)(e,`default is ignored for: ${c}`);let u=s._`${c} === undefined`;"empty"===l.useDefaults&&(u=s._`${u} || ${c} === null || ${c} === ""`),i.if(u,s._`${c} = ${(0,s.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:s}=e.schema;if("object"===t&&n)for(const t in n)i(e,t,n[t].default);else"array"===t&&Array.isArray(s)&&s.forEach(((t,n)=>i(e,n,t.default)))}},4815:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const s=n(5667),r=n(453),i=n(8876),o=n(453),a=n(313),l=n(5005),c=n(3099),u=n(3487),h=n(2141),d=n(2531),m=n(6776),p=n(4181);function f({gen:e,validateName:t,schema:n,schemaEnv:s,opts:r},i){r.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,s.$async,(()=>{e.code(u._`"use strict"; ${g(n,r)}`),function(e,t){e.if(h.default.valCxt,(()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)}),(()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)}))}(e,r),e.code(i)})):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(r)}`,s.$async,(()=>e.code(g(n,r)).code(i)))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,m.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:s,self:r}=e;t.$ref&&s.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(t,r.RULES)&&r.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return A(e,[],!1,t);const n=(0,r.getSchemaTypes)(e.schema);A(e,n,!(0,r.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:s,opts:r}){const i=n.$comment;if(!0===r.$comment)e.code(u._`${h.default.self}.logger.log(${i})`);else if("function"==typeof r.$comment){const n=u.str`${s}/$comment`,r=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${i}, ${n}, ${r}.schema)`)}}function A(e,t,n,s){const{gen:r,schema:a,data:l,allErrors:c,opts:d,self:p}=e,{RULES:f}=p;function g(m){(0,i.shouldUseGroup)(a,m)&&(m.type?(r.if((0,o.checkDataType)(m.type,l,d.strictNumbers)),S(e,m),1===t.length&&t[0]===m.type&&n&&(r.else(),(0,o.reportTypeError)(e)),r.endIf()):S(e,m),c||r.if(u._`${h.default.errors} === ${s||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(a,f)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{x(e.dataTypes,t)||E(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const s of e.dataTypes)x(t,s)?n.push(s):t.includes("integer")&&"number"===s&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&E(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const s in n){const r=n[s];if("object"==typeof r&&(0,i.shouldUseRule)(e.schema,r)){const{type:n}=r.definition;n.length&&!n.some((e=>{return s=e,(n=t).includes(s)||"number"===s&&n.includes("integer");var n,s}))&&E(e,`missing type "${n.join(",")}" for keyword "${s}"`)}}}(e,e.dataTypes))}(e,t),r.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):r.block((()=>I(e,"$ref",f.all.$ref.definition)))}function S(e,t){const{gen:n,schema:s,opts:{useDefaults:r}}=e;r&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,i.shouldUseRule)(s,n)&&I(e,n.keyword,n.definition,t.type)}))}function x(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function E(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,m.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:s}=e;f(e,(()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,m.checkStrictMode)(e,"default is ignored in the schema root")}(e),s.let(h.default.vErrors,null),s.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:s,ValidationError:r,opts:i}=e;n.$async?t.if(u._`${h.default.errors} === 0`,(()=>t.return(h.default.data)),(()=>t.throw(u._`new ${r}(${h.default.vErrors})`))):(t.assign(u._`${s}.errors`,h.default.vErrors),i.unevaluated&&function({gen:e,evaluated:t,props:n,items:s}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),s instanceof u.Name&&e.assign(u._`${t}.items`,s)}(e),t.return(u._`${h.default.errors} === 0`))}(e)}))}(e):f(e,(()=>(0,s.topBoolOrEmptySchema)(e)))};class T{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,m.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",$(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",h.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?p.reportExtraError:p.reportError)(this,this.def.error,t)}$dataError(){(0,p.reportError)(this,this.def.$dataError||p.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,p.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:s,schemaType:r,def:i}=this;n.if((0,u.or)(u._`${s} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(r.length||i.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:s,it:r}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,o.checkDataTypes)(e,t,r.opts.strictNumbers,o.DataType.Wrong)}`}return u.nil}(),function(){if(s.validateSchema){const n=e.scopeValue("validate$data",{ref:s.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,c.getSubschema)(this.it,e);(0,c.extendSubschemaData)(n,this.it,e),(0,c.extendSubschemaMode)(n,e);const r={...this.it,...n,items:void 0,props:void 0};return function(e,t){b(e)&&(v(e),y(e))?function(e,t){const{schema:n,gen:s,opts:r}=e;r.$comment&&n.$comment&&C(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,d.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const i=s.const("_errs",h.default.errors);w(e,i),s.var(t,u._`${i} === ${h.default.errors}`)}(e,t):(0,s.boolOrEmptySchema)(e,t)}(r,t),r}mergeEvaluated(e,t){const{it:n,gen:s}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=m.mergeEvaluated.props(s,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=m.mergeEvaluated.items(s,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:s}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return s.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function I(e,t,n,s){const r=new T(e,n,t);"code"in n?n.code(r,s):r.$data&&n.validate?(0,l.funcKeywordCode)(r,n):"macro"in n?(0,l.macroKeywordCode)(r,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(r,n)}t.KeywordCxt=T;const _=/^\/(?:[^~]|~0|~1)*$/,M=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function $(e,{dataLevel:t,dataNames:n,dataPathArr:s}){let r,i;if(""===e)return h.default.rootData;if("/"===e[0]){if(!_.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);r=e,i=h.default.rootData}else{const o=M.exec(e);if(!o)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+o[1];if(r=o[2],"#"===r){if(a>=t)throw new Error(l("property/index",a));return s[t-a]}if(a>t)throw new Error(l("data",a));if(i=n[t-a],!r)return i}let o=i;const a=r.split("/");for(const e of a)e&&(i=u._`${i}${(0,u.getProperty)((0,m.unescapeJsonPointer)(e))}`,o=u._`${o} && ${i}`);return o;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=$},5005:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const s=n(3487),r=n(2141),i=n(412),o=n(4181);function a(e){const{gen:t,data:n,it:r}=e;t.if(r.parentData,(()=>t.assign(n,s._`${r.parentData}[${r.parentDataProperty}]`)))}function l(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,s.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:r,schema:i,parentSchema:o,it:a}=e,c=t.macro.call(a.self,i,o,a),u=l(n,r,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const h=n.name("valid");e.subschema({schema:c,schemaPath:s.nil,errSchemaPath:`${a.errSchemaPath}/${r}`,topSchemaRef:u,compositeRule:!0},h),e.pass(h,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:c,keyword:u,schema:h,parentSchema:d,$data:m,it:p}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(p,t);const f=!m&&t.compile?t.compile.call(p.self,h,d,p):t.validate,g=l(c,u,f),y=c.let("valid");function b(n=(t.async?s._`await `:s.nil)){const o=p.opts.passContext?r.default.this:r.default.self,a=!("compile"in t&&!m||!1===t.schema);c.assign(y,s._`${n}${(0,i.callValidateCode)(e,g,o,a)}`,t.modifying)}function v(e){var n;c.if((0,s.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)b(),t.modifying&&a(e),v((()=>e.error()));else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try((()=>b(s._`await `)),(t=>c.assign(y,!1).if(s._`${t} instanceof ${p.ValidationError}`,(()=>c.assign(e,s._`${t}.errors`)),(()=>c.throw(t))))),e}():function(){const e=s._`${g}.errors`;return c.assign(e,null),b(s.nil),e}();t.modifying&&a(e),v((()=>function(e,t){const{gen:n}=e;n.if(s._`Array.isArray(${t})`,(()=>{n.assign(r.default.vErrors,s._`${r.default.vErrors} === null ? ${t} : ${r.default.vErrors}.concat(${t})`).assign(r.default.errors,s._`${r.default.vErrors}.length`),(0,o.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:s},r,i){if(Array.isArray(r.keyword)?!r.keyword.includes(i):r.keyword!==i)throw new Error("ajv implementation error");const o=r.dependencies;if(null==o?void 0:o.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${i}: ${o.join(",")}`);if(r.validateSchema&&!r.validateSchema(e[i])){const e=`keyword "${i}" value is invalid at path "${s}": `+n.errorsText(r.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},3099:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const s=n(3487),r=n(6776);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:i,schemaPath:o,errSchemaPath:a,topSchemaRef:l}){if(void 0!==t&&void 0!==i)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const i=e.schema[t];return void 0===n?{schema:i,schemaPath:s._`${e.schemaPath}${(0,s.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:i[n],schemaPath:s._`${e.schemaPath}${(0,s.getProperty)(t)}${(0,s.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,r.escapeFragment)(n)}`}}if(void 0!==i){if(void 0===o||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:i,schemaPath:o,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:i,data:o,dataTypes:a,propertyName:l}){if(void 0!==o&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=t;if(void 0!==n){const{errorPath:o,dataPathArr:a,opts:l}=t;u(c.let("data",s._`${t.data}${(0,s.getProperty)(n)}`,!0)),e.errorPath=s.str`${o}${(0,r.getErrorPath)(n,i,l.jsPropertySyntax)}`,e.parentDataProperty=s._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==o&&(u(o instanceof s.Name?o:c.let("data",o,!0)),void 0!==l&&(e.propertyName=l)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:s,createErrors:r,allErrors:i}){void 0!==s&&(e.compositeRule=s),void 0!==r&&(e.createErrors=r),void 0!==i&&(e.allErrors=i),e.jtdDiscriminator=t,e.jtdMetadata=n}},7159:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var s=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return s.KeywordCxt}});var r=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return r.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return r.CodeGen}});const i=n(7426),o=n(6646),a=n(3141),l=n(5173),c=n(3487),u=n(2531),h=n(453),d=n(6776),m=n(4775),p=n(3589),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'},w=200;function C(e){var t,n,s,r,i,o,a,l,c,u,h,d,m,g,y,b,v,C,A,S,x,E,T,I,_;const M=e.strict,$=null===(t=e.code)||void 0===t?void 0:t.optimize,N=!0===$||void 0===$?1:$||0,L=null!==(s=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==s?s:f,P=null!==(r=e.uriResolver)&&void 0!==r?r:p.default;return{strictSchema:null===(o=null!==(i=e.strictSchema)&&void 0!==i?i:M)||void 0===o||o,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:M)||void 0===l||l,strictTypes:null!==(u=null!==(c=e.strictTypes)&&void 0!==c?c:M)&&void 0!==u?u:"log",strictTuples:null!==(d=null!==(h=e.strictTuples)&&void 0!==h?h:M)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(m=e.strictRequired)&&void 0!==m?m:M)&&void 0!==g&&g,code:e.code?{...e.code,optimize:N,regExp:L}:{optimize:N,regExp:L},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:w,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:w,meta:null===(v=e.meta)||void 0===v||v,messages:null===(C=e.messages)||void 0===C||C,inlineRefs:null===(A=e.inlineRefs)||void 0===A||A,schemaId:null!==(S=e.schemaId)&&void 0!==S?S:"$id",addUsedSchema:null===(x=e.addUsedSchema)||void 0===x||x,validateSchema:null===(E=e.validateSchema)||void 0===E||E,validateFormats:null===(T=e.validateFormats)||void 0===T||T,unicodeRegExp:null===(I=e.unicodeRegExp)||void 0===I||I,int32range:null===(_=e.int32range)||void 0===_||_,uriResolver:P}}class A{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...C(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return M;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const s=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),S.call(this,b,e,"NOT SUPPORTED"),S.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=_.call(this),e.formats&&T.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&I.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),E.call(this),e.validateFormats=s}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let s=m;"id"===n&&(s={...m},s.id=s.$id,delete s.$id),t&&e&&this.addMetaSchema(s,s[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const s=n(t);return"$async"in n||(this.errors=n.errors),s}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return s.call(this,e,t);async function s(e,t){await r.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||i.call(this,n)}async function r(e){e&&!this.getSchema(e)&&await s.call(this,{$ref:e},!0)}async function i(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof o.default))throw t;return a.call(this,t),await l.call(this,t.missingSchema),i.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function l(e){const n=await c.call(this,e);this.refs[e]||await r.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function c(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,s=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,s);return this}let r;if("object"==typeof e){const{schemaId:t}=this.opts;if(r=e[t],void 0!==r&&"string"!=typeof r)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||r),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,s,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const s=this.validate(n,e);if(!s&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return s}getSchema(e){let t;for(;"string"==typeof(t=x.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,s=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,s,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=x.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if(N.call(this,n,t),!t)return(0,d.eachItem)(n,(e=>L.call(this,e))),this;R.call(this,t);const s={...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)};return(0,d.eachItem)(n,0===s.type.length?e=>L.call(this,e,s):e=>s.type.forEach((t=>L.call(this,e,s,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const s of t){const t=s.split("/").slice(1);let r=e;for(const e of t)r=r[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:s}=t.definition,i=r[e];s&&i&&(r[e]=k(i))}}return e}_removeAllSchemas(e,t){for(const n in e){const s=e[n];t&&!t.test(n)||("string"==typeof s?delete e[n]:s&&!s.meta&&(this._cache.delete(s.schema),delete e[n]))}}_addSchema(e,t,n,s=this.opts.validateSchema,r=this.opts.addUsedSchema){let i;const{schemaId:o}=this.opts;if("object"==typeof e)i=e[o];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(i||n);const c=u.getSchemaRefs.call(this,e,n);return a=new l.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:n,localRefs:c}),this._cache.set(a.schema,a),r&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),s&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function S(e,t,n,s="error"){for(const r in e){const i=r;i in t&&this.logger[s](`${n}: option ${r}. ${e[i]}`)}}function x(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function E(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function T(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function I(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function _(){const e={...this.opts};for(const t of g)delete e[t];return e}t.default=A,A.ValidationError=i.default,A.MissingRefError=o.default;const M={log(){},warn(){},error(){}},$=/^[a-z_$][a-z0-9_$:-]*$/i;function N(e,t){const{RULES:n}=this;if((0,d.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!$.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function L(e,t,n){var s;const r=null==t?void 0:t.post;if(n&&r)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:i}=this;let o=r?i.post:i.rules.find((({type:e})=>e===n));if(o||(o={type:n,rules:[]},i.rules.push(o)),i.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)}};t.before?P.call(this,o,a,t.before):o.rules.push(a),i.all[e]=a,null===(s=t.implements)||void 0===s||s.forEach((e=>this.addKeyword(e)))}function P(e,t,n){const s=e.rules.findIndex((e=>e.keyword===n));s>=0?e.rules.splice(s,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function R(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=k(t)),e.validateSchema=this.compile(t,!0))}const O={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function k(e){return{anyOf:[e,O]}}},4087:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(2577),r=n(996),i=n(5568),o=n(6795),a=n(235),l=n(2567),c=n(1233),u=n(1968),h=["/properties"];t.default=function(e){return[s,r,i,o,a,t(this,l),c,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,h):n}}},3510:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4063);s.code='require("ajv/dist/runtime/equal").default',t.default=s},4499:(e,t)=>{"use strict";function n(e){const t=e.length;let n,s=0,r=0;for(;r<t;)s++,n=e.charCodeAt(r++),n>=55296&&n<=56319&&r<t&&(n=e.charCodeAt(r),56320==(64512&n)&&r++);return s}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},3589:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(540);s.code='require("ajv/dist/runtime/uri").default',t.default=s},7426:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},4783:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const s=n(3487),r=n(6776),i={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:s}=t;Array.isArray(s)?o(e,s):(0,r.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function o(e,t){const{gen:n,schema:i,data:o,keyword:a,it:l}=e;l.items=!0;const c=n.const("len",s._`${o}.length`);if(!1===i)e.setParams({len:t.length}),e.pass(s._`${c} <= ${t.length}`);else if("object"==typeof i&&!(0,r.alwaysValidSchema)(l,i)){const i=n.var("valid",s._`${c} <= ${t.length}`);n.if((0,s.not)(i),(()=>function(i){n.forRange("i",t.length,c,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:r.Type.Num},i),l.allErrors||n.if((0,s.not)(i),(()=>n.break()))}))}(i))),e.ok(i)}}t.validateAdditionalItems=o,t.default=i},9351:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(2141),o=n(6776),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>r._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:l,errsCount:c,it:u}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:h,opts:d}=u;if(u.props=!0,"all"!==d.removeAdditional&&(0,o.alwaysValidSchema)(u,n))return;const m=(0,s.allSchemaProperties)(a.properties),p=(0,s.allSchemaProperties)(a.patternProperties);function f(e){t.code(r._`delete ${l}[${e}]`)}function g(s){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)f(s);else{if(!1===n)return e.setParams({additionalProperty:s}),e.error(),void(h||t.break());if("object"==typeof n&&!(0,o.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===d.removeAdditional?(y(s,n,!1),t.if((0,r.not)(n),(()=>{e.reset(),f(s)}))):(y(s,n),h||t.if((0,r.not)(n),(()=>t.break())))}}}function y(t,n,s){const r={keyword:"additionalProperties",dataProp:t,dataPropType:o.Type.Str};!1===s&&Object.assign(r,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(r,n)}t.forIn("key",l,(n=>{m.length||p.length?t.if(function(n){let i;if(m.length>8){const e=(0,o.schemaRefOrVal)(u,a.properties,"properties");i=(0,s.isOwnProperty)(t,e,n)}else i=m.length?(0,r.or)(...m.map((e=>r._`${n} === ${e}`))):r.nil;return p.length&&(i=(0,r.or)(i,...p.map((t=>r._`${(0,s.usePattern)(e,t)}.test(${n})`)))),(0,r.not)(i)}(n),(()=>g(n))):g(n)})),e.ok(r._`${c} === ${i.default.errors}`)}};t.default=a},1125:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:r}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const i=t.name("valid");n.forEach(((t,n)=>{if((0,s.alwaysValidSchema)(r,t))return;const o=e.subschema({keyword:"allOf",schemaProp:n},i);e.ok(i),e.mergeEvaluated(o)}))}};t.default=r},19:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(412).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=s},9864:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?s.str`must contain at least ${e} valid item(s)`:s.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?s._`{minContains: ${e}}`:s._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:i,data:o,it:a}=e;let l,c;const{minContains:u,maxContains:h}=i;a.opts.next?(l=void 0===u?1:u,c=h):l=1;const d=t.const("len",s._`${o}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,r.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,r.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,r.alwaysValidSchema)(a,n)){let t=s._`${d} >= ${l}`;return void 0!==c&&(t=s._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const m=t.name("valid");function p(){const e=t.name("_valid"),n=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(s._`${e}++`),void 0===c?t.if(s._`${e} >= ${l}`,(()=>t.assign(m,!0).break())):(t.if(s._`${e} > ${c}`,(()=>t.assign(m,!1).break())),1===l?t.assign(m,!0):t.if(s._`${e} >= ${l}`,(()=>t.assign(m,!0))))}(n)))))}function f(n,s){t.forRange("i",0,d,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:r.Type.Num,compositeRule:!0},n),s()}))}void 0===c&&1===l?f(m,(()=>t.if(m,(()=>t.break())))):0===l?(t.let(m,!0),void 0!==c&&t.if(s._`${o}.length > 0`,p)):(t.let(m,!1),p()),e.result(m,(()=>e.reset()))}};t.default=i},7772:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const s=n(3487),r=n(6776),i=n(412);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const r=1===t?"property":"properties";return s.str`must have ${r} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:r}})=>s._`{property: ${e},
5
+ || ${a} === "boolean" || ${r} === null`).assign(l,o._`[${r}]`)}}s.else(),p(e),s.endIf(),s.if(o._`${l} !== undefined`,(()=>{s.assign(r,l),function({gen:e,parentData:t,parentDataProperty:n},s){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${n}]`,s)))}(e,l)}))}(e,t,a):p(e)}))}return c};const u=new Set(["string","number","integer","boolean","null"]);function h(e,t,n,s=l.Correct){const r=s===l.Correct?o.operators.EQ:o.operators.NEQ;let i;switch(e){case"null":return o._`${t} ${r} null`;case"array":i=o._`Array.isArray(${t})`;break;case"object":i=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":i=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":i=a();break;default:return o._`typeof ${t} ${r} ${e}`}return s===l.Correct?i:(0,o.not)(i);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,n?o._`isFinite(${t})`:o.nil)}}function d(e,t,n,s){if(1===e.length)return h(e[0],t,n,s);let r;const i=(0,a.toHash)(e);if(i.array&&i.object){const e=o._`typeof ${t} != "object"`;r=i.null?e:o._`!${t} || ${e}`,delete i.null,delete i.array,delete i.object}else r=o.nil;i.number&&delete i.integer;for(const e in i)r=(0,o.and)(r,h(e,t,n,s));return r}t.checkDataType=h,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:n,schema:s}=e,r=(0,a.schemaRefOrVal)(e,s,"type");return{gen:t,keyword:"type",data:n,schema:s.type,schemaCode:r,schemaValue:r,parentSchema:s,params:{},it:e}}(e);(0,i.reportError)(t,m)}t.reportTypeError=p},313:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const s=n(3487),r=n(6776);function i(e,t,n){const{gen:i,compositeRule:o,data:a,opts:l}=e;if(void 0===n)return;const c=s._`${a}${(0,s.getProperty)(t)}`;if(o)return void(0,r.checkStrictMode)(e,`default is ignored for: ${c}`);let u=s._`${c} === undefined`;"empty"===l.useDefaults&&(u=s._`${u} || ${c} === null || ${c} === ""`),i.if(u,s._`${c} = ${(0,s.stringify)(n)}`)}t.assignDefaults=function(e,t){const{properties:n,items:s}=e.schema;if("object"===t&&n)for(const t in n)i(e,t,n[t].default);else"array"===t&&Array.isArray(s)&&s.forEach(((t,n)=>i(e,n,t.default)))}},4815:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.getData=t.KeywordCxt=t.validateFunctionCode=void 0;const s=n(5667),r=n(453),i=n(8876),o=n(453),a=n(313),l=n(5005),c=n(3099),u=n(3487),h=n(2141),d=n(2531),m=n(6776),p=n(4181);function f({gen:e,validateName:t,schema:n,schemaEnv:s,opts:r},i){r.code.es5?e.func(t,u._`${h.default.data}, ${h.default.valCxt}`,s.$async,(()=>{e.code(u._`"use strict"; ${g(n,r)}`),function(e,t){e.if(h.default.valCxt,(()=>{e.var(h.default.instancePath,u._`${h.default.valCxt}.${h.default.instancePath}`),e.var(h.default.parentData,u._`${h.default.valCxt}.${h.default.parentData}`),e.var(h.default.parentDataProperty,u._`${h.default.valCxt}.${h.default.parentDataProperty}`),e.var(h.default.rootData,u._`${h.default.valCxt}.${h.default.rootData}`),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`${h.default.valCxt}.${h.default.dynamicAnchors}`)}),(()=>{e.var(h.default.instancePath,u._`""`),e.var(h.default.parentData,u._`undefined`),e.var(h.default.parentDataProperty,u._`undefined`),e.var(h.default.rootData,h.default.data),t.dynamicRef&&e.var(h.default.dynamicAnchors,u._`{}`)}))}(e,r),e.code(i)})):e.func(t,u._`${h.default.data}, ${function(e){return u._`{${h.default.instancePath}="", ${h.default.parentData}, ${h.default.parentDataProperty}, ${h.default.rootData}=${h.default.data}${e.dynamicRef?u._`, ${h.default.dynamicAnchors}={}`:u.nil}}={}`}(r)}`,s.$async,(()=>e.code(g(n,r)).code(i)))}function g(e,t){const n="object"==typeof e&&e[t.schemaId];return n&&(t.code.source||t.code.process)?u._`/*# sourceURL=${n} */`:u.nil}function y({schema:e,self:t}){if("boolean"==typeof e)return!e;for(const n in e)if(t.RULES.all[n])return!0;return!1}function b(e){return"boolean"!=typeof e.schema}function v(e){(0,m.checkUnknownRules)(e),function(e){const{schema:t,errSchemaPath:n,opts:s,self:r}=e;t.$ref&&s.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(t,r.RULES)&&r.logger.warn(`$ref: keywords ignored in schema at path "${n}"`)}(e)}function w(e,t){if(e.opts.jtd)return A(e,[],!1,t);const n=(0,r.getSchemaTypes)(e.schema);A(e,n,!(0,r.coerceAndCheckDataType)(e,n),t)}function C({gen:e,schemaEnv:t,schema:n,errSchemaPath:s,opts:r}){const i=n.$comment;if(!0===r.$comment)e.code(u._`${h.default.self}.logger.log(${i})`);else if("function"==typeof r.$comment){const n=u.str`${s}/$comment`,r=e.scopeValue("root",{ref:t.root});e.code(u._`${h.default.self}.opts.$comment(${i}, ${n}, ${r}.schema)`)}}function A(e,t,n,s){const{gen:r,schema:a,data:l,allErrors:c,opts:d,self:p}=e,{RULES:f}=p;function g(m){(0,i.shouldUseGroup)(a,m)&&(m.type?(r.if((0,o.checkDataType)(m.type,l,d.strictNumbers)),S(e,m),1===t.length&&t[0]===m.type&&n&&(r.else(),(0,o.reportTypeError)(e)),r.endIf()):S(e,m),c||r.if(u._`${h.default.errors} === ${s||0}`))}!a.$ref||!d.ignoreKeywordsWithRef&&(0,m.schemaHasRulesButRef)(a,f)?(d.jtd||function(e,t){!e.schemaEnv.meta&&e.opts.strictTypes&&(function(e,t){t.length&&(e.dataTypes.length?(t.forEach((t=>{x(e.dataTypes,t)||E(e,`type "${t}" not allowed by context "${e.dataTypes.join(",")}"`)})),function(e,t){const n=[];for(const s of e.dataTypes)x(t,s)?n.push(s):t.includes("integer")&&"number"===s&&n.push("integer");e.dataTypes=n}(e,t)):e.dataTypes=t)}(e,t),e.opts.allowUnionTypes||function(e,t){t.length>1&&(2!==t.length||!t.includes("null"))&&E(e,"use allowUnionTypes to allow union type keyword")}(e,t),function(e,t){const n=e.self.RULES.all;for(const s in n){const r=n[s];if("object"==typeof r&&(0,i.shouldUseRule)(e.schema,r)){const{type:n}=r.definition;n.length&&!n.some((e=>{return s=e,(n=t).includes(s)||"number"===s&&n.includes("integer");var n,s}))&&E(e,`missing type "${n.join(",")}" for keyword "${s}"`)}}}(e,e.dataTypes))}(e,t),r.block((()=>{for(const e of f.rules)g(e);g(f.post)}))):r.block((()=>_(e,"$ref",f.all.$ref.definition)))}function S(e,t){const{gen:n,schema:s,opts:{useDefaults:r}}=e;r&&(0,a.assignDefaults)(e,t.type),n.block((()=>{for(const n of t.rules)(0,i.shouldUseRule)(s,n)&&_(e,n.keyword,n.definition,t.type)}))}function x(e,t){return e.includes(t)||"integer"===t&&e.includes("number")}function E(e,t){t+=` at "${e.schemaEnv.baseId+e.errSchemaPath}" (strictTypes)`,(0,m.checkStrictMode)(e,t,e.opts.strictTypes)}t.validateFunctionCode=function(e){b(e)&&(v(e),y(e))?function(e){const{schema:t,opts:n,gen:s}=e;f(e,(()=>{n.$comment&&t.$comment&&C(e),function(e){const{schema:t,opts:n}=e;void 0!==t.default&&n.useDefaults&&n.strictSchema&&(0,m.checkStrictMode)(e,"default is ignored in the schema root")}(e),s.let(h.default.vErrors,null),s.let(h.default.errors,0),n.unevaluated&&function(e){const{gen:t,validateName:n}=e;e.evaluated=t.const("evaluated",u._`${n}.evaluated`),t.if(u._`${e.evaluated}.dynamicProps`,(()=>t.assign(u._`${e.evaluated}.props`,u._`undefined`))),t.if(u._`${e.evaluated}.dynamicItems`,(()=>t.assign(u._`${e.evaluated}.items`,u._`undefined`)))}(e),w(e),function(e){const{gen:t,schemaEnv:n,validateName:s,ValidationError:r,opts:i}=e;n.$async?t.if(u._`${h.default.errors} === 0`,(()=>t.return(h.default.data)),(()=>t.throw(u._`new ${r}(${h.default.vErrors})`))):(t.assign(u._`${s}.errors`,h.default.vErrors),i.unevaluated&&function({gen:e,evaluated:t,props:n,items:s}){n instanceof u.Name&&e.assign(u._`${t}.props`,n),s instanceof u.Name&&e.assign(u._`${t}.items`,s)}(e),t.return(u._`${h.default.errors} === 0`))}(e)}))}(e):f(e,(()=>(0,s.topBoolOrEmptySchema)(e)))};class T{constructor(e,t,n){if((0,l.validateKeywordUsage)(e,t,n),this.gen=e.gen,this.allErrors=e.allErrors,this.keyword=n,this.data=e.data,this.schema=e.schema[n],this.$data=t.$data&&e.opts.$data&&this.schema&&this.schema.$data,this.schemaValue=(0,m.schemaRefOrVal)(e,this.schema,n,this.$data),this.schemaType=t.schemaType,this.parentSchema=e.schema,this.params={},this.it=e,this.def=t,this.$data)this.schemaCode=e.gen.const("vSchema",N(this.$data,e));else if(this.schemaCode=this.schemaValue,!(0,l.validSchemaType)(this.schema,t.schemaType,t.allowUndefined))throw new Error(`${n} value must be ${JSON.stringify(t.schemaType)}`);("code"in t?t.trackErrors:!1!==t.errors)&&(this.errsCount=e.gen.const("_errs",h.default.errors))}result(e,t,n){this.failResult((0,u.not)(e),t,n)}failResult(e,t,n){this.gen.if(e),n?n():this.error(),t?(this.gen.else(),t(),this.allErrors&&this.gen.endIf()):this.allErrors?this.gen.endIf():this.gen.else()}pass(e,t){this.failResult((0,u.not)(e),void 0,t)}fail(e){if(void 0===e)return this.error(),void(this.allErrors||this.gen.if(!1));this.gen.if(e),this.error(),this.allErrors?this.gen.endIf():this.gen.else()}fail$data(e){if(!this.$data)return this.fail(e);const{schemaCode:t}=this;this.fail(u._`${t} !== undefined && (${(0,u.or)(this.invalid$data(),e)})`)}error(e,t,n){if(t)return this.setParams(t),this._error(e,n),void this.setParams({});this._error(e,n)}_error(e,t){(e?p.reportExtraError:p.reportError)(this,this.def.error,t)}$dataError(){(0,p.reportError)(this,this.def.$dataError||p.keyword$DataError)}reset(){if(void 0===this.errsCount)throw new Error('add "trackErrors" to keyword definition');(0,p.resetErrorsCount)(this.gen,this.errsCount)}ok(e){this.allErrors||this.gen.if(e)}setParams(e,t){t?Object.assign(this.params,e):this.params=e}block$data(e,t,n=u.nil){this.gen.block((()=>{this.check$data(e,n),t()}))}check$data(e=u.nil,t=u.nil){if(!this.$data)return;const{gen:n,schemaCode:s,schemaType:r,def:i}=this;n.if((0,u.or)(u._`${s} === undefined`,t)),e!==u.nil&&n.assign(e,!0),(r.length||i.validateSchema)&&(n.elseIf(this.invalid$data()),this.$dataError(),e!==u.nil&&n.assign(e,!1)),n.else()}invalid$data(){const{gen:e,schemaCode:t,schemaType:n,def:s,it:r}=this;return(0,u.or)(function(){if(n.length){if(!(t instanceof u.Name))throw new Error("ajv implementation error");const e=Array.isArray(n)?n:[n];return u._`${(0,o.checkDataTypes)(e,t,r.opts.strictNumbers,o.DataType.Wrong)}`}return u.nil}(),function(){if(s.validateSchema){const n=e.scopeValue("validate$data",{ref:s.validateSchema});return u._`!${n}(${t})`}return u.nil}())}subschema(e,t){const n=(0,c.getSubschema)(this.it,e);(0,c.extendSubschemaData)(n,this.it,e),(0,c.extendSubschemaMode)(n,e);const r={...this.it,...n,items:void 0,props:void 0};return function(e,t){b(e)&&(v(e),y(e))?function(e,t){const{schema:n,gen:s,opts:r}=e;r.$comment&&n.$comment&&C(e),function(e){const t=e.schema[e.opts.schemaId];t&&(e.baseId=(0,d.resolveUrl)(e.opts.uriResolver,e.baseId,t))}(e),function(e){if(e.schema.$async&&!e.schemaEnv.$async)throw new Error("async schema in sync schema")}(e);const i=s.const("_errs",h.default.errors);w(e,i),s.var(t,u._`${i} === ${h.default.errors}`)}(e,t):(0,s.boolOrEmptySchema)(e,t)}(r,t),r}mergeEvaluated(e,t){const{it:n,gen:s}=this;n.opts.unevaluated&&(!0!==n.props&&void 0!==e.props&&(n.props=m.mergeEvaluated.props(s,e.props,n.props,t)),!0!==n.items&&void 0!==e.items&&(n.items=m.mergeEvaluated.items(s,e.items,n.items,t)))}mergeValidEvaluated(e,t){const{it:n,gen:s}=this;if(n.opts.unevaluated&&(!0!==n.props||!0!==n.items))return s.if(t,(()=>this.mergeEvaluated(e,u.Name))),!0}}function _(e,t,n,s){const r=new T(e,n,t);"code"in n?n.code(r,s):r.$data&&n.validate?(0,l.funcKeywordCode)(r,n):"macro"in n?(0,l.macroKeywordCode)(r,n):(n.compile||n.validate)&&(0,l.funcKeywordCode)(r,n)}t.KeywordCxt=T;const I=/^\/(?:[^~]|~0|~1)*$/,M=/^([0-9]+)(#|\/(?:[^~]|~0|~1)*)?$/;function N(e,{dataLevel:t,dataNames:n,dataPathArr:s}){let r,i;if(""===e)return h.default.rootData;if("/"===e[0]){if(!I.test(e))throw new Error(`Invalid JSON-pointer: ${e}`);r=e,i=h.default.rootData}else{const o=M.exec(e);if(!o)throw new Error(`Invalid JSON-pointer: ${e}`);const a=+o[1];if(r=o[2],"#"===r){if(a>=t)throw new Error(l("property/index",a));return s[t-a]}if(a>t)throw new Error(l("data",a));if(i=n[t-a],!r)return i}let o=i;const a=r.split("/");for(const e of a)e&&(i=u._`${i}${(0,u.getProperty)((0,m.unescapeJsonPointer)(e))}`,o=u._`${o} && ${i}`);return o;function l(e,n){return`Cannot access ${e} ${n} levels up, current level is ${t}`}}t.getData=N},5005:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateKeywordUsage=t.validSchemaType=t.funcKeywordCode=t.macroKeywordCode=void 0;const s=n(3487),r=n(2141),i=n(412),o=n(4181);function a(e){const{gen:t,data:n,it:r}=e;t.if(r.parentData,(()=>t.assign(n,s._`${r.parentData}[${r.parentDataProperty}]`)))}function l(e,t,n){if(void 0===n)throw new Error(`keyword "${t}" failed to compile`);return e.scopeValue("keyword","function"==typeof n?{ref:n}:{ref:n,code:(0,s.stringify)(n)})}t.macroKeywordCode=function(e,t){const{gen:n,keyword:r,schema:i,parentSchema:o,it:a}=e,c=t.macro.call(a.self,i,o,a),u=l(n,r,c);!1!==a.opts.validateSchema&&a.self.validateSchema(c,!0);const h=n.name("valid");e.subschema({schema:c,schemaPath:s.nil,errSchemaPath:`${a.errSchemaPath}/${r}`,topSchemaRef:u,compositeRule:!0},h),e.pass(h,(()=>e.error(!0)))},t.funcKeywordCode=function(e,t){var n;const{gen:c,keyword:u,schema:h,parentSchema:d,$data:m,it:p}=e;!function({schemaEnv:e},t){if(t.async&&!e.$async)throw new Error("async keyword in sync schema")}(p,t);const f=!m&&t.compile?t.compile.call(p.self,h,d,p):t.validate,g=l(c,u,f),y=c.let("valid");function b(n=(t.async?s._`await `:s.nil)){const o=p.opts.passContext?r.default.this:r.default.self,a=!("compile"in t&&!m||!1===t.schema);c.assign(y,s._`${n}${(0,i.callValidateCode)(e,g,o,a)}`,t.modifying)}function v(e){var n;c.if((0,s.not)(null!==(n=t.valid)&&void 0!==n?n:y),e)}e.block$data(y,(function(){if(!1===t.errors)b(),t.modifying&&a(e),v((()=>e.error()));else{const n=t.async?function(){const e=c.let("ruleErrs",null);return c.try((()=>b(s._`await `)),(t=>c.assign(y,!1).if(s._`${t} instanceof ${p.ValidationError}`,(()=>c.assign(e,s._`${t}.errors`)),(()=>c.throw(t))))),e}():function(){const e=s._`${g}.errors`;return c.assign(e,null),b(s.nil),e}();t.modifying&&a(e),v((()=>function(e,t){const{gen:n}=e;n.if(s._`Array.isArray(${t})`,(()=>{n.assign(r.default.vErrors,s._`${r.default.vErrors} === null ? ${t} : ${r.default.vErrors}.concat(${t})`).assign(r.default.errors,s._`${r.default.vErrors}.length`),(0,o.extendErrors)(e)}),(()=>e.error()))}(e,n)))}})),e.ok(null!==(n=t.valid)&&void 0!==n?n:y)},t.validSchemaType=function(e,t,n=!1){return!t.length||t.some((t=>"array"===t?Array.isArray(e):"object"===t?e&&"object"==typeof e&&!Array.isArray(e):typeof e==t||n&&void 0===e))},t.validateKeywordUsage=function({schema:e,opts:t,self:n,errSchemaPath:s},r,i){if(Array.isArray(r.keyword)?!r.keyword.includes(i):r.keyword!==i)throw new Error("ajv implementation error");const o=r.dependencies;if(null==o?void 0:o.some((t=>!Object.prototype.hasOwnProperty.call(e,t))))throw new Error(`parent schema must have dependencies of ${i}: ${o.join(",")}`);if(r.validateSchema&&!r.validateSchema(e[i])){const e=`keyword "${i}" value is invalid at path "${s}": `+n.errorsText(r.validateSchema.errors);if("log"!==t.validateSchema)throw new Error(e);n.logger.error(e)}}},3099:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.extendSubschemaMode=t.extendSubschemaData=t.getSubschema=void 0;const s=n(3487),r=n(6776);t.getSubschema=function(e,{keyword:t,schemaProp:n,schema:i,schemaPath:o,errSchemaPath:a,topSchemaRef:l}){if(void 0!==t&&void 0!==i)throw new Error('both "keyword" and "schema" passed, only one allowed');if(void 0!==t){const i=e.schema[t];return void 0===n?{schema:i,schemaPath:s._`${e.schemaPath}${(0,s.getProperty)(t)}`,errSchemaPath:`${e.errSchemaPath}/${t}`}:{schema:i[n],schemaPath:s._`${e.schemaPath}${(0,s.getProperty)(t)}${(0,s.getProperty)(n)}`,errSchemaPath:`${e.errSchemaPath}/${t}/${(0,r.escapeFragment)(n)}`}}if(void 0!==i){if(void 0===o||void 0===a||void 0===l)throw new Error('"schemaPath", "errSchemaPath" and "topSchemaRef" are required with "schema"');return{schema:i,schemaPath:o,topSchemaRef:l,errSchemaPath:a}}throw new Error('either "keyword" or "schema" must be passed')},t.extendSubschemaData=function(e,t,{dataProp:n,dataPropType:i,data:o,dataTypes:a,propertyName:l}){if(void 0!==o&&void 0!==n)throw new Error('both "data" and "dataProp" passed, only one allowed');const{gen:c}=t;if(void 0!==n){const{errorPath:o,dataPathArr:a,opts:l}=t;u(c.let("data",s._`${t.data}${(0,s.getProperty)(n)}`,!0)),e.errorPath=s.str`${o}${(0,r.getErrorPath)(n,i,l.jsPropertySyntax)}`,e.parentDataProperty=s._`${n}`,e.dataPathArr=[...a,e.parentDataProperty]}function u(n){e.data=n,e.dataLevel=t.dataLevel+1,e.dataTypes=[],t.definedProperties=new Set,e.parentData=t.data,e.dataNames=[...t.dataNames,n]}void 0!==o&&(u(o instanceof s.Name?o:c.let("data",o,!0)),void 0!==l&&(e.propertyName=l)),a&&(e.dataTypes=a)},t.extendSubschemaMode=function(e,{jtdDiscriminator:t,jtdMetadata:n,compositeRule:s,createErrors:r,allErrors:i}){void 0!==s&&(e.compositeRule=s),void 0!==r&&(e.createErrors=r),void 0!==i&&(e.allErrors=i),e.jtdDiscriminator=t,e.jtdMetadata=n}},7159:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.CodeGen=t.Name=t.nil=t.stringify=t.str=t._=t.KeywordCxt=void 0;var s=n(4815);Object.defineProperty(t,"KeywordCxt",{enumerable:!0,get:function(){return s.KeywordCxt}});var r=n(3487);Object.defineProperty(t,"_",{enumerable:!0,get:function(){return r._}}),Object.defineProperty(t,"str",{enumerable:!0,get:function(){return r.str}}),Object.defineProperty(t,"stringify",{enumerable:!0,get:function(){return r.stringify}}),Object.defineProperty(t,"nil",{enumerable:!0,get:function(){return r.nil}}),Object.defineProperty(t,"Name",{enumerable:!0,get:function(){return r.Name}}),Object.defineProperty(t,"CodeGen",{enumerable:!0,get:function(){return r.CodeGen}});const i=n(7426),o=n(6646),a=n(3141),l=n(5173),c=n(3487),u=n(2531),h=n(453),d=n(6776),m=n(4775),p=n(3589),f=(e,t)=>new RegExp(e,t);f.code="new RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},v={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'},w=200;function C(e){var t,n,s,r,i,o,a,l,c,u,h,d,m,g,y,b,v,C,A,S,x,E,T,_,I;const M=e.strict,N=null===(t=e.code)||void 0===t?void 0:t.optimize,$=!0===N||void 0===N?1:N||0,L=null!==(s=null===(n=e.code)||void 0===n?void 0:n.regExp)&&void 0!==s?s:f,P=null!==(r=e.uriResolver)&&void 0!==r?r:p.default;return{strictSchema:null===(o=null!==(i=e.strictSchema)&&void 0!==i?i:M)||void 0===o||o,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:M)||void 0===l||l,strictTypes:null!==(u=null!==(c=e.strictTypes)&&void 0!==c?c:M)&&void 0!==u?u:"log",strictTuples:null!==(d=null!==(h=e.strictTuples)&&void 0!==h?h:M)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(m=e.strictRequired)&&void 0!==m?m:M)&&void 0!==g&&g,code:e.code?{...e.code,optimize:$,regExp:L}:{optimize:$,regExp:L},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:w,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:w,meta:null===(v=e.meta)||void 0===v||v,messages:null===(C=e.messages)||void 0===C||C,inlineRefs:null===(A=e.inlineRefs)||void 0===A||A,schemaId:null!==(S=e.schemaId)&&void 0!==S?S:"$id",addUsedSchema:null===(x=e.addUsedSchema)||void 0===x||x,validateSchema:null===(E=e.validateSchema)||void 0===E||E,validateFormats:null===(T=e.validateFormats)||void 0===T||T,unicodeRegExp:null===(_=e.unicodeRegExp)||void 0===_||_,int32range:null===(I=e.int32range)||void 0===I||I,uriResolver:P}}class A{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...C(e)};const{es5:t,lines:n}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:n}),this.logger=function(e){if(!1===e)return M;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const s=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),S.call(this,b,e,"NOT SUPPORTED"),S.call(this,v,e,"DEPRECATED","warn"),this._metaOpts=I.call(this),e.formats&&T.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&_.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),E.call(this),e.validateFormats=s}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:n}=this.opts;let s=m;"id"===n&&(s={...m},s.id=s.$id,delete s.$id),t&&e&&this.addMetaSchema(s,s[n],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let n;if("string"==typeof e){if(n=this.getSchema(e),!n)throw new Error(`no schema with key or ref "${e}"`)}else n=this.compile(e);const s=n(t);return"$async"in n||(this.errors=n.errors),s}compile(e,t){const n=this._addSchema(e,t);return n.validate||this._compileSchemaEnv(n)}compileAsync(e,t){if("function"!=typeof this.opts.loadSchema)throw new Error("options.loadSchema should be a function");const{loadSchema:n}=this.opts;return s.call(this,e,t);async function s(e,t){await r.call(this,e.$schema);const n=this._addSchema(e,t);return n.validate||i.call(this,n)}async function r(e){e&&!this.getSchema(e)&&await s.call(this,{$ref:e},!0)}async function i(e){try{return this._compileSchemaEnv(e)}catch(t){if(!(t instanceof o.default))throw t;return a.call(this,t),await l.call(this,t.missingSchema),i.call(this,e)}}function a({missingSchema:e,missingRef:t}){if(this.refs[e])throw new Error(`AnySchema ${e} is loaded but ${t} cannot be resolved`)}async function l(e){const n=await c.call(this,e);this.refs[e]||await r.call(this,n.$schema),this.refs[e]||this.addSchema(n,e,t)}async function c(e){const t=this._loading[e];if(t)return t;try{return await(this._loading[e]=n(e))}finally{delete this._loading[e]}}}addSchema(e,t,n,s=this.opts.validateSchema){if(Array.isArray(e)){for(const t of e)this.addSchema(t,void 0,n,s);return this}let r;if("object"==typeof e){const{schemaId:t}=this.opts;if(r=e[t],void 0!==r&&"string"!=typeof r)throw new Error(`schema ${t} must be string`)}return t=(0,u.normalizeId)(t||r),this._checkUnique(t),this.schemas[t]=this._addSchema(e,n,t,s,!0),this}addMetaSchema(e,t,n=this.opts.validateSchema){return this.addSchema(e,t,!0,n),this}validateSchema(e,t){if("boolean"==typeof e)return!0;let n;if(n=e.$schema,void 0!==n&&"string"!=typeof n)throw new Error("$schema must be a string");if(n=n||this.opts.defaultMeta||this.defaultMeta(),!n)return this.logger.warn("meta-schema not available"),this.errors=null,!0;const s=this.validate(n,e);if(!s&&t){const e="schema is invalid: "+this.errorsText();if("log"!==this.opts.validateSchema)throw new Error(e);this.logger.error(e)}return s}getSchema(e){let t;for(;"string"==typeof(t=x.call(this,e));)e=t;if(void 0===t){const{schemaId:n}=this.opts,s=new l.SchemaEnv({schema:{},schemaId:n});if(t=l.resolveSchema.call(this,s,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=x.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let n=e[this.opts.schemaId];return n&&(n=(0,u.normalizeId)(n),delete this.schemas[n],delete this.refs[n]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let n;if("string"==typeof e)n=e,"object"==typeof t&&(this.logger.warn("these parameters are deprecated, see docs for addKeyword"),t.keyword=n);else{if("object"!=typeof e||void 0!==t)throw new Error("invalid addKeywords parameters");if(n=(t=e).keyword,Array.isArray(n)&&!n.length)throw new Error("addKeywords: keyword must be string or non-empty array")}if($.call(this,n,t),!t)return(0,d.eachItem)(n,(e=>L.call(this,e))),this;R.call(this,t);const s={...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)};return(0,d.eachItem)(n,0===s.type.length?e=>L.call(this,e,s):e=>s.type.forEach((t=>L.call(this,e,s,t)))),this}getKeyword(e){const t=this.RULES.all[e];return"object"==typeof t?t.definition:!!t}removeKeyword(e){const{RULES:t}=this;delete t.keywords[e],delete t.all[e];for(const n of t.rules){const t=n.rules.findIndex((t=>t.keyword===e));t>=0&&n.rules.splice(t,1)}return this}addFormat(e,t){return"string"==typeof t&&(t=new RegExp(t)),this.formats[e]=t,this}errorsText(e=this.errors,{separator:t=", ",dataVar:n="data"}={}){return e&&0!==e.length?e.map((e=>`${n}${e.instancePath} ${e.message}`)).reduce(((e,n)=>e+t+n)):"No errors"}$dataMetaSchema(e,t){const n=this.RULES.all;e=JSON.parse(JSON.stringify(e));for(const s of t){const t=s.split("/").slice(1);let r=e;for(const e of t)r=r[e];for(const e in n){const t=n[e];if("object"!=typeof t)continue;const{$data:s}=t.definition,i=r[e];s&&i&&(r[e]=k(i))}}return e}_removeAllSchemas(e,t){for(const n in e){const s=e[n];t&&!t.test(n)||("string"==typeof s?delete e[n]:s&&!s.meta&&(this._cache.delete(s.schema),delete e[n]))}}_addSchema(e,t,n,s=this.opts.validateSchema,r=this.opts.addUsedSchema){let i;const{schemaId:o}=this.opts;if("object"==typeof e)i=e[o];else{if(this.opts.jtd)throw new Error("schema must be object");if("boolean"!=typeof e)throw new Error("schema must be object or boolean")}let a=this._cache.get(e);if(void 0!==a)return a;n=(0,u.normalizeId)(i||n);const c=u.getSchemaRefs.call(this,e,n);return a=new l.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:n,localRefs:c}),this._cache.set(a.schema,a),r&&!n.startsWith("#")&&(n&&this._checkUnique(n),this.refs[n]=a),s&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function S(e,t,n,s="error"){for(const r in e){const i=r;i in t&&this.logger[s](`${n}: option ${r}. ${e[i]}`)}}function x(e){return e=(0,u.normalizeId)(e),this.schemas[e]||this.refs[e]}function E(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function T(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function _(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const n=e[t];n.keyword||(n.keyword=t),this.addKeyword(n)}}}function I(){const e={...this.opts};for(const t of g)delete e[t];return e}t.default=A,A.ValidationError=i.default,A.MissingRefError=o.default;const M={log(){},warn(){},error(){}},N=/^[a-z_$][a-z0-9_$:-]*$/i;function $(e,t){const{RULES:n}=this;if((0,d.eachItem)(e,(e=>{if(n.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!N.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function L(e,t,n){var s;const r=null==t?void 0:t.post;if(n&&r)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:i}=this;let o=r?i.post:i.rules.find((({type:e})=>e===n));if(o||(o={type:n,rules:[]},i.rules.push(o)),i.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,h.getJSONTypes)(t.type),schemaType:(0,h.getJSONTypes)(t.schemaType)}};t.before?P.call(this,o,a,t.before):o.rules.push(a),i.all[e]=a,null===(s=t.implements)||void 0===s||s.forEach((e=>this.addKeyword(e)))}function P(e,t,n){const s=e.rules.findIndex((e=>e.keyword===n));s>=0?e.rules.splice(s,0,t):(e.rules.push(t),this.logger.warn(`rule ${n} is not defined`))}function R(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=k(t)),e.validateSchema=this.compile(t,!0))}const O={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function k(e){return{anyOf:[e,O]}}},4087:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(2577),r=n(996),i=n(5568),o=n(6795),a=n(235),l=n(2567),c=n(1233),u=n(1968),h=["/properties"];t.default=function(e){return[s,r,i,o,a,t(this,l),c,t(this,u)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,n){return e?t.$dataMetaSchema(n,h):n}}},3510:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4063);s.code='require("ajv/dist/runtime/equal").default',t.default=s},4499:(e,t)=>{"use strict";function n(e){const t=e.length;let n,s=0,r=0;for(;r<t;)s++,n=e.charCodeAt(r++),n>=55296&&n<=56319&&r<t&&(n=e.charCodeAt(r),56320==(64512&n)&&r++);return s}Object.defineProperty(t,"__esModule",{value:!0}),t.default=n,n.code='require("ajv/dist/runtime/ucs2length").default'},3589:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(540);s.code='require("ajv/dist/runtime/uri").default',t.default=s},7426:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class n extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=n},4783:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const s=n(3487),r=n(6776),i={keyword:"additionalItems",type:"array",schemaType:["boolean","object"],before:"uniqueItems",error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{parentSchema:t,it:n}=e,{items:s}=t;Array.isArray(s)?o(e,s):(0,r.checkStrictMode)(n,'"additionalItems" is ignored when "items" is not an array of schemas')}};function o(e,t){const{gen:n,schema:i,data:o,keyword:a,it:l}=e;l.items=!0;const c=n.const("len",s._`${o}.length`);if(!1===i)e.setParams({len:t.length}),e.pass(s._`${c} <= ${t.length}`);else if("object"==typeof i&&!(0,r.alwaysValidSchema)(l,i)){const i=n.var("valid",s._`${c} <= ${t.length}`);n.if((0,s.not)(i),(()=>function(i){n.forRange("i",t.length,c,(t=>{e.subschema({keyword:a,dataProp:t,dataPropType:r.Type.Num},i),l.allErrors||n.if((0,s.not)(i),(()=>n.break()))}))}(i))),e.ok(i)}}t.validateAdditionalItems=o,t.default=i},9351:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(2141),o=n(6776),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>r._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:n,parentSchema:a,data:l,errsCount:c,it:u}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:h,opts:d}=u;if(u.props=!0,"all"!==d.removeAdditional&&(0,o.alwaysValidSchema)(u,n))return;const m=(0,s.allSchemaProperties)(a.properties),p=(0,s.allSchemaProperties)(a.patternProperties);function f(e){t.code(r._`delete ${l}[${e}]`)}function g(s){if("all"===d.removeAdditional||d.removeAdditional&&!1===n)f(s);else{if(!1===n)return e.setParams({additionalProperty:s}),e.error(),void(h||t.break());if("object"==typeof n&&!(0,o.alwaysValidSchema)(u,n)){const n=t.name("valid");"failing"===d.removeAdditional?(y(s,n,!1),t.if((0,r.not)(n),(()=>{e.reset(),f(s)}))):(y(s,n),h||t.if((0,r.not)(n),(()=>t.break())))}}}function y(t,n,s){const r={keyword:"additionalProperties",dataProp:t,dataPropType:o.Type.Str};!1===s&&Object.assign(r,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(r,n)}t.forIn("key",l,(n=>{m.length||p.length?t.if(function(n){let i;if(m.length>8){const e=(0,o.schemaRefOrVal)(u,a.properties,"properties");i=(0,s.isOwnProperty)(t,e,n)}else i=m.length?(0,r.or)(...m.map((e=>r._`${n} === ${e}`))):r.nil;return p.length&&(i=(0,r.or)(i,...p.map((t=>r._`${(0,s.usePattern)(e,t)}.test(${n})`)))),(0,r.not)(i)}(n),(()=>g(n))):g(n)})),e.ok(r._`${c} === ${i.default.errors}`)}};t.default=a},1125:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:n,it:r}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");const i=t.name("valid");n.forEach(((t,n)=>{if((0,s.alwaysValidSchema)(r,t))return;const o=e.subschema({keyword:"allOf",schemaProp:n},i);e.ok(i),e.mergeEvaluated(o)}))}};t.default=r},19:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:n(412).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=s},9864:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?s.str`must contain at least ${e} valid item(s)`:s.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?s._`{minContains: ${e}}`:s._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:n,parentSchema:i,data:o,it:a}=e;let l,c;const{minContains:u,maxContains:h}=i;a.opts.next?(l=void 0===u?1:u,c=h):l=1;const d=t.const("len",s._`${o}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,r.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,r.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,r.alwaysValidSchema)(a,n)){let t=s._`${d} >= ${l}`;return void 0!==c&&(t=s._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const m=t.name("valid");function p(){const e=t.name("_valid"),n=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(s._`${e}++`),void 0===c?t.if(s._`${e} >= ${l}`,(()=>t.assign(m,!0).break())):(t.if(s._`${e} > ${c}`,(()=>t.assign(m,!1).break())),1===l?t.assign(m,!0):t.if(s._`${e} >= ${l}`,(()=>t.assign(m,!0))))}(n)))))}function f(n,s){t.forRange("i",0,d,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:r.Type.Num,compositeRule:!0},n),s()}))}void 0===c&&1===l?f(m,(()=>t.if(m,(()=>t.break())))):0===l?(t.let(m,!0),void 0!==c&&t.if(s._`${o}.length > 0`,p)):(t.let(m,!1),p()),e.result(m,(()=>e.reset()))}};t.default=i},7772:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const s=n(3487),r=n(6776),i=n(412);t.error={message:({params:{property:e,depsCount:t,deps:n}})=>{const r=1===t?"property":"properties";return s.str`must have ${r} ${n} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:n,missingProperty:r}})=>s._`{property: ${e},
6
6
  missingProperty: ${r},
7
7
  depsCount: ${t},
8
- deps: ${n}}`};const o={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const s in e)"__proto__"!==s&&((Array.isArray(e[s])?t:n)[s]=e[s]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:r,it:o}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,i.propertyInData)(n,r,l,o.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),o.allErrors?n.if(u,(()=>{for(const t of c)(0,i.checkReportMissingProp)(e,t)})):(n.if(s._`${u} && (${(0,i.checkMissingProp)(e,c,a)})`),(0,i.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:s,keyword:o,it:a}=e,l=n.name("valid");for(const c in t)(0,r.alwaysValidSchema)(a,t[c])||(n.if((0,i.propertyInData)(n,s,c,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:o,schemaProp:c},l);e.mergeValidEvaluated(t,l)}),(()=>n.var(l,!0))),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=o},7274:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(7772),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,s.validateSchemaDeps)(e)};t.default=r},9434:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>s.str`must match "${e.ifClause}" schema`,params:({params:e})=>s._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:i}=e;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(i,'"if" without "then" and "else" is ignored');const a=o(i,"then"),l=o(i,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,s.not)(u),h("else"));function h(n,r){return()=>{const i=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(i,c),r?t.assign(r,s._`${n}`):e.setParams({ifClause:n})}}e.pass(c,(()=>e.error(!0)))}};function o(e,t){const n=e.schema[t];return void 0!==n&&!(0,r.alwaysValidSchema)(e,n)}t.default=i},8200:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4783),r=n(2924),i=n(4665),o=n(1119),a=n(9864),l=n(7772),c=n(3708),u=n(9351),h=n(6239),d=n(2296),m=n(2182),p=n(19),f=n(4200),g=n(1125),y=n(9434),b=n(6552);t.default=function(e=!1){const t=[m.default,p.default,f.default,g.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(r.default,o.default):t.push(s.default,i.default),t.push(a.default),t}},4665:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const s=n(3487),r=n(6776),i=n(412),o={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,r.alwaysValidSchema)(n,t)||e.ok((0,i.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:i,parentSchema:o,data:a,keyword:l,it:c}=e;!function(e){const{opts:s,errSchemaPath:i}=c,o=n.length,a=o===e.minItems&&(o===e.maxItems||!1===e[t]);if(s.strictTuples&&!a){const e=`"${l}" is ${o}-tuple, but minItems or maxItems/${t} are not specified or different at path "${i}"`;(0,r.checkStrictMode)(c,e,s.strictTuples)}}(o),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(i,n.length,c.items));const u=i.name("valid"),h=i.const("len",s._`${a}.length`);n.forEach(((t,n)=>{(0,r.alwaysValidSchema)(c,t)||(i.if(s._`${h} > ${n}`,(()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=o},1119:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(412),o=n(4783),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:s}=e,{prefixItems:a}=n;s.items=!0,(0,r.alwaysValidSchema)(s,t)||(a?(0,o.validateAdditionalItems)(e,a):e.ok((0,i.validateArray)(e)))}};t.default=a},2182:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:r}=e;if((0,s.alwaysValidSchema)(r,n))return void e.fail();const i=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},i),e.failResult(i,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=r},4200:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>s._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:i,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(o.opts.discriminator&&i.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block((function(){a.forEach(((n,i)=>{let a;(0,r.alwaysValidSchema)(o,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:i,compositeRule:!0},u),i>0&&t.if(s._`${u} && ${l}`).assign(l,!1).assign(c,s._`[${c}, ${i}]`).else(),t.if(u,(()=>{t.assign(l,!0),t.assign(c,i),a&&e.mergeEvaluated(a,s.Name)}))}))})),e.result(l,(()=>e.reset()),(()=>e.error(!0)))}};t.default=i},2296:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(6776),o=n(6776),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,s.allSchemaProperties)(n),d=h.filter((e=>(0,i.alwaysValidSchema)(c,n[e])));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const m=u.strictSchema&&!u.allowMatchingProperties&&l.properties,p=t.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,o.evaluatedPropsToName)(t,c.props));const{props:f}=c;function g(e){for(const t in m)new RegExp(e).test(t)&&(0,i.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(i=>{t.if(r._`${(0,s.usePattern)(e,n)}.test(${i})`,(()=>{const s=d.includes(n);s||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:i,dataPropType:o.Type.Str},p),c.opts.unevaluated&&!0!==f?t.assign(r._`${f}[${i}]`,!0):s||c.allErrors||t.if((0,r.not)(p),(()=>t.break()))}))}))}!function(){for(const e of h)m&&g(e),c.allErrors?y(e):(t.var(p,!0),y(e),t.if(p))}()}};t.default=a},2924:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4665),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,s.validateTuple)(e,"items")};t.default=r},6239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4815),r=n(412),i=n(6776),o=n(9351),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&o.default.code(new s.KeywordCxt(c,o.default,"additionalProperties"));const u=(0,r.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=i.mergeEvaluated.props(t,(0,i.toHash)(u),c.props));const h=u.filter((e=>!(0,i.alwaysValidSchema)(c,n[e])));if(0===h.length)return;const d=t.name("valid");for(const n of h)m(n)?p(n):(t.if((0,r.propertyInData)(t,l,n,c.opts.ownProperties)),p(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function m(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function p(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},3708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>s._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:i,it:o}=e;if((0,r.alwaysValidSchema)(o,n))return;const a=t.name("valid");t.forIn("key",i,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,s.not)(a),(()=>{e.error(!0),o.allErrors||t.break()}))})),e.ok(a)}};t.default=i},6552:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,s.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=r},412:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const s=n(3487),r=n(6776),i=n(2141),o=n(6776);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:s._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return s._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,r){const i=s._`${t}${(0,s.getProperty)(n)} === undefined`;return r?(0,s.or)(i,(0,s.not)(l(e,t,n))):i}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:r,it:i}=e;n.if(c(n,r,t,i.opts.ownProperties),(()=>{e.setParams({missingProperty:s._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},r,i){return(0,s.or)(...r.map((r=>(0,s.and)(c(e,t,r,n.ownProperties),s._`${i} = ${r}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,r){const i=s._`${t}${(0,s.getProperty)(n)} !== undefined`;return r?s._`${i} && ${l(e,t,n)}`:i},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,r.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:r,schemaPath:o,errorPath:a},it:l},c,u,h){const d=h?s._`${e}, ${t}, ${r}${o}`:t,m=[[i.default.instancePath,(0,s.strConcat)(i.default.instancePath,a)],[i.default.parentData,l.parentData],[i.default.parentDataProperty,l.parentDataProperty],[i.default.rootData,i.default.rootData]];l.opts.dynamicRef&&m.push([i.default.dynamicAnchors,i.default.dynamicAnchors]);const p=s._`${d}, ${n.object(...m)}`;return u!==s.nil?s._`${c}.call(${u}, ${p})`:s._`${c}(${p})`};const h=s._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const r=t.unicodeRegExp?"u":"",{regExp:i}=t.code,a=i(n,r);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:s._`${"new RegExp"===i.code?h:(0,o.useFunc)(e,i)}(${n}, ${r})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:i,it:o}=e,a=t.name("valid");if(o.allErrors){const e=t.let("valid",!0);return l((()=>t.assign(e,!1))),e}return t.var(a,!0),l((()=>t.break())),a;function l(o){const l=t.const("len",s._`${n}.length`);t.forRange("i",0,l,(n=>{e.subschema({keyword:i,dataProp:n,dataPropType:r.Type.Num},a),t.if((0,s.not)(a),o)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:i,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,r.alwaysValidSchema)(o,e)))&&!o.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block((()=>n.forEach(((n,r)=>{const o=e.subschema({keyword:i,schemaProp:r,compositeRule:!0},l);t.assign(a,s._`${a} || ${l}`),e.mergeValidEvaluated(o,l)||t.if((0,s.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},8386:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},5684:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(8386),r=n(8280),i=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",s.default,r.default];t.default=i},8280:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const s=n(6646),r=n(412),i=n(3487),o=n(2141),a=n(5173),l=n(6776),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:r}=e,{baseId:o,schemaEnv:l,validateName:c,opts:d,self:m}=r,{root:p}=l;if(("#"===n||"#/"===n)&&o===p.baseId)return function(){if(l===p)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:p});return h(e,i._`${n}.validate`,p,p.$async)}();const f=a.resolveRef.call(m,p,o,n);if(void 0===f)throw new s.default(r.opts.uriResolver,o,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(f):function(s){const r=t.scopeValue("schema",!0===d.code.source?{ref:s,code:(0,i.stringify)(s)}:{ref:s}),o=t.name("valid"),a=e.subschema({schema:s,dataTypes:[],schemaPath:i.nil,topSchemaRef:r,errSchemaPath:n},o);e.mergeEvaluated(a),e.ok(o)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):i._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,s){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,m=d.passContext?o.default.this:i.nil;function p(e){const t=i._`${e}.errors`;a.assign(o.default.vErrors,i._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`),a.assign(o.default.errors,i._`${o.default.vErrors}.length`)}function f(e){var t;if(!c.opts.unevaluated)return;const s=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(s&&!s.dynamicProps)void 0!==s.props&&(c.props=l.mergeEvaluated.props(a,s.props,c.props));else{const t=a.var("props",i._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,i.Name)}if(!0!==c.items)if(s&&!s.dynamicItems)void 0!==s.items&&(c.items=l.mergeEvaluated.items(a,s.items,c.items));else{const t=a.var("items",i._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,i.Name)}}s?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(i._`await ${(0,r.callValidateCode)(e,t,m)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(i._`!(${e} instanceof ${c.ValidationError})`,(()=>a.throw(e))),p(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,r.callValidateCode)(e,t,m),(()=>f(t)),(()=>p(t)))}t.getValidate=u,t.callRef=h,t.default=c},1240:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(9306),i=n(5173),o=n(6776),a={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===r.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>s._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:a,parentSchema:l,it:c}=e,{oneOf:u}=l;if(!c.opts.discriminator)throw new Error("discriminator: requires discriminator option");const h=a.propertyName;if("string"!=typeof h)throw new Error("discriminator: requires propertyName");if(a.mapping)throw new Error("discriminator: mapping is not supported");if(!u)throw new Error("discriminator: requires oneOf keyword");const d=t.let("valid",!1),m=t.const("tag",s._`${n}${(0,s.getProperty)(h)}`);function p(n){const r=t.name("valid"),i=e.subschema({keyword:"oneOf",schemaProp:n},r);return e.mergeEvaluated(i,s.Name),r}t.if(s._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=r(l);let s=!0;for(let t=0;t<u.length;t++){let l=u[t];(null==l?void 0:l.$ref)&&!(0,o.schemaHasRulesButRef)(l,c.self.RULES)&&(l=i.resolveRef.call(c.self,c.schemaEnv.root,c.baseId,null==l?void 0:l.$ref),l instanceof i.SchemaEnv&&(l=l.schema));const d=null===(e=null==l?void 0:l.properties)||void 0===e?void 0:e[h];if("object"!=typeof d)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${h}"`);s=s&&(n||r(l)),a(d,t)}if(!s)throw new Error(`discriminator: "${h}" must be required`);return t;function r({required:e}){return Array.isArray(e)&&e.includes(h)}function a(e,t){if(e.const)d(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${h}" must have "const" or "enum"`);for(const n of e.enum)d(n,t)}}function d(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${h}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(s._`${m} === ${e}`),t.assign(d,p(n[e]));t.else(),e.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:h}),t.endIf()}()),(()=>e.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:h}))),e.ok(d)}};t.default=a},9306:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,(n=t.DiscrError||(t.DiscrError={})).Tag="tag",n.Mapping="mapping"},7299:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(5684),r=n(2649),i=n(8200),o=n(6121),a=n(1448),l=n(808),c=n(9502),u=n(6167),h=[o.default,s.default,r.default,(0,i.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},3924:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(5684),r=n(2649),i=n(8200),o=n(9502),a=n(6167),l=[s.default,r.default,(0,i.default)(),o.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},6215:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const s=n(3487),r=n(2141),i=n(5173),o=n(8280),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=s._`${r.default.dynamicAnchors}${(0,s.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:s}=e.it,{root:r,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=s.opts,h=new i.SchemaEnv({schema:n,schemaId:u,root:r,baseId:a,localRefs:l,meta:c});return i.compileSchema.call(s,h),(0,o.getValidate)(e,h)}(e);n.if(s._`!${l}`,(()=>n.assign(l,c)))}t.dynamicAnchor=l,t.default=a},1919:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const s=n(3487),r=n(2141),i=n(8280),o={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:o,it:a}=e;if("#"!==t[0])throw new Error(`"${o}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",s._`${r.default.dynamicAnchors}${(0,s.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,s){return s?()=>n.block((()=>{(0,i.callRef)(e,t),n.let(s,!0)})):()=>(0,i.callRef)(e,t)}}t.dynamicRef=a,t.default=o},6121:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6215),r=n(1919),i=n(4094),o=n(3944),a=[s.default,r.default,i.default,o.default];t.default=a},4094:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6215),r=n(6776),i={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,s.dynamicAnchor)(e,""):(0,r.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=i},3944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1919),r={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,s.dynamicRef)(e,e.schema)};t.default=r},9651:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>s.str`must match format "${e}"`,params:({schemaCode:e})=>s._`{format: ${e}}`},code(e,t){const{gen:n,data:r,$data:i,schema:o,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(i?function(){const i=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),o=n.const("fDef",s._`${i}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(s._`typeof ${o} == "object" && !(${o} instanceof RegExp)`,(()=>n.assign(l,s._`${o}.type || "string"`).assign(u,s._`${o}.validate`)),(()=>n.assign(l,s._`"string"`).assign(u,o))),e.fail$data((0,s.or)(!1===c.strictSchema?s.nil:s._`${a} && !${u}`,function(){const e=h.$async?s._`(${o}.async ? await ${u}(${r}) : ${u}(${r}))`:s._`${u}(${r})`,n=s._`(typeof ${u} == "function" ? ${e} : ${u}.test(${r}))`;return s._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const i=d.formats[o];if(!i)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${o}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===i)return;const[a,l,m]=function(e){const t=e instanceof RegExp?(0,s.regexpCode)(e):c.code.formats?s._`${c.code.formats}${(0,s.getProperty)(o)}`:void 0,r=n.scopeValue("formats",{key:o,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,r]:[e.type||"string",e.validate,s._`${r}.validate`]}(i);a===t&&e.pass(function(){if("object"==typeof i&&!(i instanceof RegExp)&&i.async){if(!h.$async)throw new Error("async format in sync schema");return s._`await ${m}(${r})`}return"function"==typeof l?s._`${m}(${r})`:s._`${m}.test(${r})`}())}())}};t.default=r},9502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=[n(9651).default];t.default=s},6167:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},1448:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(8921),r=n(7274),i=n(3633),o=[s.default,r.default,i.default];t.default=o},808:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1782),r=n(4641),i=[s.default,r.default];t.default=i},4641:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:i,it:o}=e,a=o.items||0;if(!0===a)return;const l=t.const("len",s._`${i}.length`);if(!1===n)e.setParams({len:a}),e.fail(s._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(o,n)){const n=t.var("valid",s._`${l} <= ${a}`);t.if((0,s.not)(n),(()=>function(n,i){t.forRange("i",i,l,(i=>{e.subschema({keyword:"unevaluatedItems",dataProp:i,dataPropType:r.Type.Num},n),o.allErrors||t.if((0,s.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}o.items=!0}};t.default=i},1782:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(2141),o={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>s._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:o,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(i){if(!1===n)return e.setParams({unevaluatedProperty:i}),e.error(),void(c||t.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:i,dataPropType:r.Type.Str},n),c||t.if((0,s.not)(n),(()=>t.break()))}}u instanceof s.Name?t.if(s._`${u} !== true`,(()=>t.forIn("key",o,(e=>t.if(function(e,t){return s._`!${e} || !${e}[${t}]`}(u,e),(()=>h(e))))))):!0!==u&&t.forIn("key",o,(e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const r in e)!0===e[r]&&n.push(s._`${t} !== ${r}`);return(0,s.and)(...n)}(u,e),(()=>h(e))))),l.props=!0,e.ok(s._`${a} === ${i.default.errors}`)}};t.default=o},4693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(3510),o={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>s._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:o,schemaCode:a,schema:l}=e;o||l&&"object"==typeof l?e.fail$data(s._`!${(0,r.useFunc)(t,i.default)}(${n}, ${a})`):e.fail(s._`${l} !== ${n}`)}};t.default=o},8921:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(7772),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:s.error,code:e=>(0,s.validatePropertyDeps)(e)};t.default=r},966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(3510),o={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>s._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:o,schema:a,schemaCode:l,it:c}=e;if(!o&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,r.useFunc)(t,i.default);let m;if(u||o)m=t.let("valid"),e.block$data(m,(function(){t.assign(m,!1),t.forOf("v",l,(e=>t.if(s._`${d()}(${n}, ${e})`,(()=>t.assign(m,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);m=(0,s.or)(...a.map(((t,r)=>function(e,t){const r=a[t];return"object"==typeof r&&null!==r?s._`${d()}(${n}, ${e}[${t}])`:s._`${n} === ${r}`}(e,r))))}e.pass(m)}};t.default=o},2649:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3983),r=n(430),i=n(3229),o=n(4336),a=n(498),l=n(3301),c=n(1687),u=n(2958),h=n(4693),d=n(966),m=[s.default,r.default,i.default,o.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=m},3633:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,s.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=r},1687:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,i="maxItems"===t?s.operators.GT:s.operators.LT;e.fail$data(s._`${n}.length ${i} ${r}`)}};t.default=r},3229:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(4499),o={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o,it:a}=e,l="maxLength"===t?s.operators.GT:s.operators.LT,c=!1===a.opts.unicode?s._`${n}.length`:s._`${(0,r.useFunc)(e.gen,i.default)}(${n})`;e.fail$data(s._`${c} ${l} ${o}`)}};t.default=o},3983:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=s.operators,i={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},o={message:({keyword:e,schemaCode:t})=>s.str`must be ${i[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>s._`{comparison: ${i[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(i),type:"number",schemaType:"number",$data:!0,error:o,code(e){const{keyword:t,data:n,schemaCode:r}=e;e.fail$data(s._`${n} ${i[t].fail} ${r} || isNaN(${n})`)}};t.default=a},498:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,i="maxProperties"===t?s.operators.GT:s.operators.LT;e.fail$data(s._`Object.keys(${n}).length ${i} ${r}`)}};t.default=r},430:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>s.str`must be multiple of ${e}`,params:({schemaCode:e})=>s._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:r,it:i}=e,o=i.opts.multipleOfPrecision,a=t.let("res"),l=o?s._`Math.abs(Math.round(${a}) - ${a}) > 1e-${o}`:s._`${a} !== parseInt(${a})`;e.fail$data(s._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};t.default=r},4336:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match pattern "${e}"`,params:({schemaCode:e})=>r._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:i,schemaCode:o,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${o}, ${l}))`:(0,s.usePattern)(e,i);e.fail$data(r._`!${c}.test(${t})`)}};t.default=i},3301:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(6776),o={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>r.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>r._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:o,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(r.nil,d);else for(const t of n)(0,s.checkReportMissingProp)(e,t)}():function(){const i=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,i){e.setParams({missingProperty:n}),t.forOf(n,o,(()=>{t.assign(i,(0,s.propertyInData)(t,a,n,u.ownProperties)),t.if((0,r.not)(i),(()=>{e.error(),t.break()}))}),r.nil)}(i,n))),e.ok(n)}else t.if((0,s.checkMissingProp)(e,n,i)),(0,s.reportMissingProp)(e,i),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:s}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!s.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,i.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",o,(n=>{e.setParams({missingProperty:n}),t.if((0,s.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=o},2958:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(453),r=n(3487),i=n(6776),o=n(3510),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>r.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>r._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),m=c.items?(0,s.getSchemaTypes)(c.items):[];function p(i,o){const a=t.name("item"),l=(0,s.checkDataTypes)(m,a,h.opts.strictNumbers,s.DataType.Wrong),c=t.const("indices",r._`{}`);t.for(r._`;${i}--;`,(()=>{t.let(a,r._`${n}[${i}]`),t.if(l,r._`continue`),m.length>1&&t.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),t.if(r._`typeof ${c}[${a}] == "number"`,(()=>{t.assign(o,r._`${c}[${a}]`),e.error(),t.assign(d,!1).break()})).code(r._`${c}[${a}] = ${i}`)}))}function f(s,a){const l=(0,i.useFunc)(t,o.default),c=t.name("outer");t.label(c).for(r._`;${s}--;`,(()=>t.for(r._`${a} = ${s}; ${a}--;`,(()=>t.if(r._`${l}(${n}[${s}], ${n}[${a}])`,(()=>{e.error(),t.assign(d,!1).break(c)}))))))}e.block$data(d,(function(){const s=t.let("i",r._`${n}.length`),i=t.let("j");e.setParams({i:s,j:i}),t.assign(d,!0),t.if(r._`${s} > 1`,(()=>(m.length>0&&!m.some((e=>"object"===e||"array"===e))?p:f)(s,i)))}),r._`${u} === false`),e.ok(d)}};t.default=a},8277:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=o},5362:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},9564:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},9414:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=o},8710:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=o},3645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",s=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),s&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),s&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,s,r,i){"string"==typeof e&&(e=[[null,e,void 0]]);var o={};if(s)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(o[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);s&&o[u[0]]||(void 0!==i&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=i),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),r&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=r):u[4]="".concat(r)),t.push(u))}},t}},7537:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var s=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(s),i="/*# ".concat(r," */");return[t].concat([i]).join("\n")}return[t].join("\n")}},4063:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var s,r,i;if(Array.isArray(t)){if((s=t.length)!=n.length)return!1;for(r=s;0!=r--;)if(!e(t[r],n[r]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((s=(i=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(r=s;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,i[r]))return!1;for(r=s;0!=r--;){var o=i[r];if(!e(t[o],n[o]))return!1}return!0}return t!=t&&n!=n}},9133:function(e,t,n){var s;!function(t,r){var i={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,s,r,i){for(var o,a,l,c,u,h,d,m,p,f,g,y,b;i>=64;){for(o=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],m=n[7],f=0;f<16;f++)g=r+4*f,e[f]=(255&s[g])<<24|(255&s[g+1])<<16|(255&s[g+2])<<8|255&s[g+3];for(f=16;f<64;f++)y=((p=e[f-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,b=((p=e[f-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,e[f]=(y+e[f-7]|0)+(b+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(m+(t[f]+e[f]|0)|0)|0,b=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&l^a&l)|0,m=d,d=h,h=u,u=c+y|0,c=l,l=a,a=o,o=y+b|0;n[0]+=o,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=m,r+=64,i-=64}return r}var s=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var s=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[s++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(s=n(this.temp,this.state,e,s,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[s++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,s=this.bufferLength,r=t/536870912|0,i=t<<3,o=t%64<56?64:128;this.buffer[s]=128;for(var a=s+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=r>>>24&255,this.buffer[o-7]=r>>>16&255,this.buffer[o-6]=r>>>8&255,this.buffer[o-5]=r>>>0&255,this.buffer[o-4]=i>>>24&255,this.buffer[o-3]=i>>>16&255,this.buffer[o-2]=i>>>8&255,this.buffer[o-1]=i>>>0&255,n(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=s;var r=function(){function e(e){this.inner=new s,this.outer=new s,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new s).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function i(e){var t=(new s).update(e),n=t.digest();return t.clean(),n}function o(e,t){var n=new r(e).update(t),s=n.digest();return n.clean(),s}function a(e,t,n,s){var r=s[0];if(0===r)throw new Error("hkdf: cannot expand more");t.reset(),r>1&&t.update(e),n&&t.update(n),t.update(s),t.finish(e),s[0]++}e.HMAC=r,e.hash=i,e.default=i,e.hmac=o;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,s){void 0===t&&(t=l),void 0===s&&(s=32);for(var i=new Uint8Array([1]),c=o(t,e),u=new r(c),h=new Uint8Array(u.digestLength),d=h.length,m=new Uint8Array(s),p=0;p<s;p++)d===h.length&&(a(h,u,n,i),d=0),m[p]=h[d++];return u.clean(),h.fill(0),i.fill(0),m},e.pbkdf2=function(e,t,n,s){for(var i=new r(e),o=i.digestLength,a=new Uint8Array(4),l=new Uint8Array(o),c=new Uint8Array(o),u=new Uint8Array(s),h=0;h*o<s;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,i.reset(),i.update(t),i.update(a),i.finish(c);for(var m=0;m<o;m++)l[m]=c[m];for(m=2;m<=n;m++){i.reset(),i.update(c).finish(c);for(var p=0;p<o;p++)l[p]^=c[p]}for(m=0;m<o&&h*o+m<s;m++)u[h*o+m]=l[m]}for(h=0;h<o;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return i.clean(),u}}(i);var o=i.default;for(var a in i)o[a]=i[a];"object"==typeof e.exports?e.exports=o:void 0===(s=function(){return o}.call(i,n,i,e))||(e.exports=s)}()},1811:(e,t,n)=>{"use strict";n.d(t,{T:()=>r});const s=new Uint32Array(65536),r=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,r=t.length,i=1<<n-1;let o=-1,a=0,l=n,c=n;for(;c--;)s[e.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let e=s[t.charCodeAt(c)];const n=e|a;e|=(e&o)+o^o,a|=~(e|o),o&=e,a&i&&l++,o&i&&l--,a=a<<1|1,o=o<<1|~(n|a),a&=n}for(c=n;c--;)s[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,r=e.length,i=[],o=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let e=0;e<a;e++)o[e]=-1,i[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,r)+u;for(let t=u;t<h;t++)s[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=s[t.charCodeAt(e)],r=o[e/32|0]>>>e&1,c=i[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),m=l&h;d>>>31^r&&(o[e/32|0]^=1<<e),m>>>31^c&&(i[e/32|0]^=1<<e),d=d<<1|r,m=m<<1|c,l=m|~(u|d),a=d&u}for(let t=u;t<h;t++)s[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,m=Math.min(32,r-d)+d;for(let t=d;t<m;t++)s[e.charCodeAt(t)]|=1<<t;let p=r;for(let e=0;e<n;e++){const n=s[t.charCodeAt(e)],a=o[e/32|0]>>>e&1,l=i[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let m=u|~(d|h),f=h&d;p+=m>>>r-1&1,p-=f>>>r-1&1,m>>>31^a&&(o[e/32|0]^=1<<e),f>>>31^l&&(i[e/32|0]^=1<<e),m=m<<1|a,f=f<<1|l,h=f|~(c|m),u=m&c}for(let t=d;t<m;t++)s[e.charCodeAt(t)]=0;return p})(e,t)}},3979:(e,t)=>{"use strict";t.H$=void 0,t.H$=function(e,t,n){var s=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var s=0,r=e.length,i=t.length,o=Math.floor(Math.max(r,i)/2)-1,a=new Array(r),l=new Array(i),c=0;c<r;c++)for(var u=Math.max(0,c-o);u<=Math.min(i,c+o+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++s,a[c]=l[u]=!0;break}if(0===s)return 0;var h=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(s/r+s/i+(s-(h/=2))/s)/3}(e,t,n),r=0;if(s>.7){for(var i=Math.min(e.length,t.length),o=0;e[o]===t[o]&&o<4&&o<i;)++r,o++;s+=.1*r*(1-s)}return s}},9461:e=>{"use strict";var t=e.exports=function(e,t,s){"function"==typeof t&&(s=t,t={}),n(t,"function"==typeof(s=t.cb||s)?s:s.pre||function(){},s.post||function(){},e,"",e)};function n(e,s,r,i,o,a,l,c,u,h){if(i&&"object"==typeof i&&!Array.isArray(i)){for(var d in s(i,o,a,l,c,u,h),i){var m=i[d];if(Array.isArray(m)){if(d in t.arrayKeywords)for(var p=0;p<m.length;p++)n(e,s,r,m[p],o+"/"+d+"/"+p,a,o,d,i,p)}else if(d in t.propsKeywords){if(m&&"object"==typeof m)for(var f in m)n(e,s,r,m[f],o+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,o,d,i,f)}else(d in t.keywords||e.allKeys&&!(d in t.skipKeywords))&&n(e,s,r,m,o+"/"+d,a,o,d,i)}r(i,o,a,l,c,u,h)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},3379:e=>{"use strict";var t=[];function n(e){for(var n=-1,s=0;s<t.length;s++)if(t[s].identifier===e){n=s;break}return n}function s(e,s){for(var i={},o=[],a=0;a<e.length;a++){var l=e[a],c=s.base?l[0]+s.base:l[0],u=i[c]||0,h="".concat(c," ").concat(u);i[c]=u+1;var d=n(h),m={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(m);else{var p=r(m,s);s.byIndex=a,t.splice(a,0,{identifier:h,updater:p,references:1})}o.push(h)}return o}function r(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,r){var i=s(e=e||[],r=r||{});return function(e){e=e||[];for(var o=0;o<i.length;o++){var a=n(i[o]);t[a].references--}for(var l=s(e,r),c=0;c<i.length;c++){var u=n(i[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}i=l}}},569:e=>{"use strict";var t={};e.exports=function(e,n){var s=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!s)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");s.appendChild(n)}},9216:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},3565:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7795:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var s="";n.supports&&(s+="@supports (".concat(n.supports,") {")),n.media&&(s+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(s+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),s+=n.css,r&&(s+="}"),n.media&&(s+="}"),n.supports&&(s+="}");var i=n.sourceMap;i&&"undefined"!=typeof btoa&&(s+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(i))))," */")),t.styleTagTransform(s,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},4589:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},7241:(e,t,n)=>{"use strict";n.d(t,{D:()=>c});var s=n(4469),r=n(976),i=n(9644),o=n(8607),a=n(6286);const l=31;async function c(e,t=!1,n){const a=o.g.forColumn(e);let c;n??(n=new Map);const h=a.isHelm()?(0,i.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<h.length;e++)n.has(h[e])||n.set(h[e],`${n.size+1}`);if(a.isHelm())c=await s.functions.call("HELM:getMolFiles",{col:e}),c=function(e,t,n=!1){const s=new Array(e.length);for(let r=0;r<e.length;r++){let i=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const c=e.get(r);i=c.indexOf("\n",i)+1,i=c.indexOf("\n",i)+1,i=c.indexOf("\n",i)+1;const u=parseInt(c.substring(i,i+3)),h=parseInt(c.substring(i+3,i+6));a+=`M V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){i=c.indexOf("\n",i)+1+l,o=c.indexOf(" ",i);const s=c.substring(i,o);a+=n?`M V30 ${e+1} R${t.get(s)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(s)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<h;e++){i=c.indexOf("\n",i)+1;const t=parseInt(c.substring(i,i+3).trim()),n=parseInt(c.substring(i+3,i+6).trim());a+=`M V30 ${e+1} ${parseInt(c.substring(i+6,i+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",s[r]=a}return s}(c,n,t);else{c=new Array(e.length);for(let s=0;s<e.length;s++){const e=u(a.getSplitted(s),n,t);c[s]=e}}return r.Column.fromStrings("monomericMols",c)}function u(e,t,n=!1){let s="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";s+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,s+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++){const i=e.getCanonical(r);i!==a.G2&&(s+=n?`M V30 ${r+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`)}s+="M V30 END ATOM\n",s+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)s+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return s+="M V30 END BOND\n",s+="M V30 END CTAB\n",s+="M END",s}},9644:(e,t,n)=>{"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>xs,SeqActivityCliffsEditor:()=>Is,SeqPaletteCustom:()=>fs,SequenceSpaceEditor:()=>Ts,SplitToMonomersEditor:()=>Es,SubsequenceSearchTopMenu:()=>ir,_package:()=>ds,activityCliffs:()=>Gs,addCopyMenu:()=>br,alignSequences:()=>Ws,applyNotationProviderForCyclized:()=>Ir,bioSubstructureFilter:()=>ur,compositionAnalysis:()=>Ys,compositionAnalysisWidget:()=>Ns,convertDialog:()=>Ks,demoBioActivityCliffs:()=>Cr,demoBioAtomicLevel:()=>Ar,demoBioHelmMsaSequenceSpace:()=>Sr,demoBioSequenceSpace:()=>wr,demoBioSimilarityDiversity:()=>vr,detectMacromoleculeProbe:()=>Er,diversitySearchTopMenu:()=>sr,diversitySearchViewer:()=>nr,fastaSequenceCellRenderer:()=>Ms,getBioLib:()=>vs,getHelmMonomers:()=>Qs,getMolFromHelm:()=>Tr,getMonomerLib:()=>ws,getMonomerLibHelper:()=>ms,getRegion:()=>Ds,getRegionApp:()=>mr,getRegionHelmApp:()=>pr,getRegionPanel:()=>As,getRegionTopMenu:()=>Fs,getSeqHandler:()=>Cs,helmPreprocessingFunction:()=>Vs,hydrophobPalette:()=>ps,importBam:()=>qs,importFasta:()=>Zs,initBio:()=>ys,libraryPanel:()=>Ss,longSeqTableFasta:()=>gr,longSeqTableHelm:()=>yr,longSeqTableSeparator:()=>fr,macroMolColumnPropertyPanel:()=>$s,macromoleculeDifferenceCellRenderer:()=>Ps,macromoleculePreprocessingFunction:()=>Bs,manageMonomerLibraries:()=>lr,monomerCellRenderer:()=>zs,multipleSequenceAlignmentDialog:()=>js,packageSettingsEditor:()=>_s,saveAsFasta:()=>cr,sdfToJsonLib:()=>xr,searchSubsequenceEditor:()=>rr,separatorSequenceCellRenderer:()=>Ls,sequenceAlignment:()=>Rs,sequenceIdentityScoring:()=>or,sequenceSimilarityScoring:()=>ar,sequenceSpaceTopMenu:()=>Us,sequenceTooltip:()=>bs,similaritySearchTopMenu:()=>tr,similaritySearchViewer:()=>er,splitToMonomersTopMenu:()=>Js,testDetectMacromolecule:()=>Xs,toAtomicLevel:()=>Hs,vdRegionsViewer:()=>ks,webLogoAggApp:()=>dr,webLogoLargeApp:()=>hr,webLogoViewer:()=>Os});var s,r,i=n(4469),o=n(3870),a=n(976),l=n(3277),c=n(4628);(r=s||(s={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var u=n(701),h=n(3379),d=n.n(h),m=n(7795),p=n.n(m),f=n(569),g=n.n(f),y=n(3565),b=n.n(y),v=n(9216),w=n.n(v),C=n(4589),A=n.n(C),S=n(9414),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=p(),x.insertStyleElement=w(),d()(S.Z,x),S.Z&&S.Z.locals&&S.Z.locals;var E=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};let T=null,I=null;function _(e,t){return e&&""!=e?e:t}class M{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for KNN computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!T&&(T=yield navigator.gpu.requestAdapter(),null==T))return null;const e=yield T.requestAdapterInfo();return e?_(e.description,_(e.vendor,"No GPU description available")):null}))}().then((e=>{e?this.useWebGPU.tooltip+=` (${e})`:(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class ${constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Object.prototype.toString;const N="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class L{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach((n=>{null!=e[n].value&&(t[n]=e[n].value)})),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=o.boolInput("Plot embeddings",!0),this.clusterEmbeddingsInput=o.boolInput("Cluster embeddings",!0),this.preprocessingFunctionInputRoot=null,this.methods=[c.A.UMAP,c.A.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=o.inputs([]),this.dbScanSettingsDiv=o.inputs([]),this.preprocessingFuncSettingsDiv=o.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.A.UMAP]:new M,[c.A.T_SNE]:new $},this.dbScanParams=new L,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push(N),a.Func.find({tags:[l.n3]}).forEach((e=>{const t=e.options.get(l.vO)??"",n=e.friendlyName??e.name,s=e.options.get(l.ts)??"",r=e.options.get(l.q6)??"",i=e.options.get(l.dB)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!s.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:s?s.split(","):[],units:r?r.split(","):[],distanceFunctions:i?i.split(","):[]})})),this.tableInput=o.tableInput("Table",i.shell.tv.dataFrame,i.shell.tables,(()=>{this.onTableInputChanged()})),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=o.choiceInput("Method",c.A.UMAP,this.methods,(()=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=o.icons.settings((()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):o.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=o.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):o.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=o.inputs([]);const s=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=o.choiceInput("Encoding function",s[0],s,(()=>{this.onPreprocessingFunctionChanged()}));let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(o.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=o.icons.settings((async()=>{u?o.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=o.choiceInput("Similarity","",[],null),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find((e=>!!this.columnFunctionsMap[e.name]))??null,t=o.columnInput("Column",this.tableInput.value,e,(()=>this.onColumnInputChanged()),{filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,o.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach((e=>this.colInputRoot.append(e))),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;e&&(this.columnFunctionsMap={},e.columns.toList().forEach((e=>{Object.keys(this.supportedFunctions).forEach((t=>{const n=this.supportedFunctions[t].semTypes,s=this.supportedFunctions[t].types,r=this.supportedFunctions[t].units,i=!n.length||e.semType&&n.includes(e.semType),o=!s.length||s.includes(e.type),l=!r.length||e.getTag(a.TAGS.UNITS)&&r.includes(e.getTag(a.TAGS.UNITS));i&&o&&l&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))}))})),this.regenerateColInput())}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=o.choiceInput("Preprocessing function",t[0],t,(()=>{this.onPreprocessingFunctionChanged()}));let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(o.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){o.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=o.choiceInput("Similarity",this.availableMetrics[0],this.availableMetrics,null),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),o.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((e=>this.similarityMetricInputRoot.append(e))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return o.empty(e),Object.keys(t).forEach((n=>{const s=t[n],r="string"===s.type?o.stringInput(s.uiName,s.value??"",(()=>{s.value=r.value})):"boolean"===s.type?o.boolInput(s.uiName,s.value??!1,(()=>{s.value=r.value})):o.floatInput(s.uiName,s.value,(()=>{s.value=r.value}));e.append(r.root),s.disable?(r.enabled=!1,o.tooltip.bind(r.input??r.root,s.disableTooltip??"")):o.tooltip.bind(r.input??r.root,s.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(o.empty(e),t.inputs.length<3)return o.div();const n=t.prepare(),s=await n.buildEditor(o.div());for(let r=2;r<t.inputs.length;r++){const i=t.inputs[r];(this.preprocessingFunctionSettings[i.name]||n.inputParams[t.inputs[r].name].value||i.defaultValue)&&(this.preprocessingFunctionSettings[i.name]=this.preprocessingFunctionSettings[i.name]??n.inputParams[i.name].value??i.defaultValue);const o=s.find((e=>e.property.name===i.name));o&&(null!==this.preprocessingFunctionSettings[i.name]&&void 0!==this.preprocessingFunctionSettings[i.name]&&(o.value=this.preprocessingFunctionSettings[i.name]),o.onChanged((()=>{this.preprocessingFunctionSettings[i.name]=o.value})),e.append(o.root))}return e}getEditor(){return o.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}}const R=rxjs.operators;var O=n(5697);const k=e=>null==e;function D(e,t,n,s){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,s)}var F=n(6254);class G{constructor(e=!0,t=!0){const s=navigator.hardwareConcurrency;this._workerCount=e?Math.max(s-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(65),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],s.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],i=[1],o=s.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||i.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(s,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const s=Math.floor(n*u),g=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=m;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),m=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-s,opts:r,weights:i,aggregationMethod:o}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:i,min:o,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(h.set(i,s),o<p&&(p=o),a>f&&(f=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-p)/(f-p)})),s(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,i=[{}],o=[1],a=s.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,i,o,a):0;r<u&&(console.log(`using threshold ${u}`),r=u),i.forEach(((e,t)=>i[t].threshold=r));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(23),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((s,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&s({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:r,fnNames:t,opts:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),s({i:t,j:r,distance:i,idx:n}))}}));const m=await Promise.all(h),p=m.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(p),g=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,s={}){return await this.calcMultiColumn([e],[t],n,[s],[1])}async getKNN(e,t,n=15,s={}){return await this.multiColumnKNN([e],[t],n,[s],[1])}async getThresholdKNN(e,t,n=.8,s={}){return await this.multiColumnThresholdKnn([e],[t],n,[s],[1])}async multiColumnThresholdKnn(e,t,r=.8,i,o,a=s.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(427),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((s,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&s({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,threshold:r,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),s({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnKNN(e,t,r=15,i,o,a=s.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(282),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((s,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&s({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,nNeighbours:r,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),s({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)D(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,r=[],i,o=s.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(40),n.b))));try{const n=e[0].length*(e[0].length-1)/2,s=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*s,m=l===this._workerCount-1?n:(l+1)*s;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:r,weights:i,aggregationMethod:o}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),m=d.reduce(((e,t)=>e+t.distance.length),0),p=new Float32Array(m);let f=0;for(const e of d)p.set(e.distance,f),f+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,i=s.EUCLIDEAN){try{const s=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,n,r,i);return 1-o[Math.floor(7e7/s*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,s){const r=[],i=[],o=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=s&&(r.push(l),i.push(c),o.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(i),distance:new Float32Array(o)}}}var V,U,H=n(9657);(U=V||(V={})).none="none",U.bold="bold",U.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,s,r=V.none){var i;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(s),this.visibility=null!==(i=s.visibility)&&void 0!==i?i:new H.Z(this.lines.from.length),s.visibility||this.visibility.setAll(!0,!1),s.arrowSize&&(this.arrowWidth=s.arrowSize),this.canvas.onmousedown=e=>{-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,s,r,i,o,a,l,c,u,h,d;const m=this.sp.getOptions().look,p=this.lines.colors||this.lines.width||this.lines.opacities||this.lines.drawArrowsArr;p||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const f=m.sizeColumnName?this.sp.dataFrame.col(m.sizeColumnName):null,g=this.sp.dataFrame.filter;for(let e=0;e<this.lines.from.length;e++)if(g.get(this.lines.from[e])&&g.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:n,sizeTo:g}=this.getMarkersSizes(m,f,e),y=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let b=null==y?void 0:y.x,v=null==y?void 0:y.y;const w=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let C=null==w?void 0:w.x,A=null==w?void 0:w.y;const S=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),b&&v&&C&&A&&Math.hypot(C-b,A-v)/S>.01){if(p){const t=(null===(s=this.lines.colors)||void 0===s?void 0:s[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:"0,128,0",n=(null===(i=this.lines.opacities)||void 0===i?void 0:i[e])?null===(o=this.lines.opacities)||void 0===o?void 0:o[e]:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(a=this.lines.widths)||void 0===a?void 0:a[e])?null===(l=this.lines.widths)||void 0===l?void 0:l[e]:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const m=this.multipleLinesCounts[e];let f=null;if(m){t=this.getLineLength(b,v,C,A);const s=this.getPointOnDistance(b,v,C,A,g,t),r=this.getPointOnDistance(C,A,b,v,n,t);b=s.x,v=s.y,C=r.x,A=r.y,f=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(m,b,v,C,A,e):this.findControlPoint(m,C,A,b,v,e),this.ctx.moveTo(b,v),this.ctx.quadraticCurveTo(f.x,f.y,C,A)}else this.ctx.moveTo(b,v),this.ctx.lineTo(C,A);if((null!==(c=this.lines.drawArrows)&&void 0!==c?c:null===(u=this.lines.drawArrowsArr)||void 0===u?void 0:u.getBit(e))&&(t||(t=this.getLineLength(b,v,C,A)),t>this.arrowWidth)){const e=m?null:this.getPointOnDistance(b,v,C,A,g,t),n=m?f.x:b,s=m?f.y:v;this.canvasArrow(this.ctx,null!==(h=null==e?void 0:e.x)&&void 0!==h?h:b,null!==(d=null==e?void 0:e.y)&&void 0!==d?d:v,n,s)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,n){let s=3,r=3;return t?(s=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[n]))/2,r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[n]))/2):e.markerDefaultSize&&(s=e.markerDefaultSize/2,r=e.markerDefaultSize/2),{sizeFrom:s,sizeTo:r}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e=new H.Z(this.lines.from.length);e.setAll(!0);for(let t=-1;-1!==(t=e.findNext(t));){const n=t,s=this.lines.from[n],r=this.lines.to[n];let i=1;for(let n=t;-1!==(n=e.findNext(n));){const t=this.lines.from[n],o=this.lines.to[n];(t===s&&o===r||o===s&&t===r)&&(this.multipleLinesCounts[n]=++i,e.setBit(n,!1,!1))}i>1&&(this.multipleLinesCounts[n]=1),e.setBit(t,!1,!1)}}checkCoordsOnLine(e,t){let n=-1,s=null,r=null;const i=this.sp.getOptions().look,o=i.sizeColumnName?this.sp.dataFrame.col(i.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let l=0;l<this.lines.from.length;l++)if(a.get(this.lines.from[l])&&a.get(this.lines.to[l])&&this.visibility.getBit(l)){const{sizeFrom:a,sizeTo:c}=this.getMarkersSizes(i,o,l),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[l]),this.yAxisCol.get(this.lines.from[l])),h=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[l]),this.yAxisCol.get(this.lines.to[l]));if(this.multipleLinesCounts[l]){const n=this.getLineLength(u.x,u.y,h.x,h.y),s=this.getPointOnDistance(u.x,u.y,h.x,h.y,c,n),i=this.getPointOnDistance(h.x,h.y,null==u?void 0:u.x,null==u?void 0:u.y,a,n),o=this.lines.from[l]>this.lines.to[l]?this.findControlPoint(this.multipleLinesCounts[l],s.x,s.y,i.x,i.y,l):this.findControlPoint(this.multipleLinesCounts[l],i.x,i.y,s.x,s.y,l);r=this.calculateDistToCurveLine(l,e,t,s,i,o)}else r=this.calculateDistToStraightLine(e,t,u,h);(!s&&null!==r&&r<5||s&&null!==r&&r<s)&&(s=r,n=l)}return n}calculateDistToStraightLine(e,t,n,s){const r=Math.min(n.x,s.x),i=Math.max(n.x,s.x),o=Math.min(n.y,s.y),a=Math.max(n.y,s.y);return e>=r-2&&e<=i+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,s):null}distToStraightLineSegment(e,t,n,s){const r=(e,t,n,s)=>Math.pow(e-n,2)+Math.pow(t-s,2),i=r(n.x,n.y,s.x,s.y);if(0==i)return r(e,t,n.x,n.y);let o=((e-n.x)*(s.x-n.x)+(t-n.y)*(s.y-n.y))/i;return o=Math.max(0,Math.min(1,o)),r(e,t,n.x+o*(s.x-n.x),n.y+o*(s.y-n.y))}calculateDistToCurveLine(e,t,n,s,r,i){const o=Math.min(s.x,r.x,i.x),a=Math.max(s.x,r.x,i.x),l=Math.min(s.y,r.y,i.y),c=Math.max(s.y,r.y,i.y);if(t>=o-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-o,u=c-l;return this.calculateDistToCurveInRect(t,n,s,i,r,e,u)}return null}calculateDistToCurveInRect(e,t,n,s,r,i,o){const a=Math.floor((i+o)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new H.Z(a);for(let i=0;i<c.length;i++){const o=i*l,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*s.x+Math.pow(o,2)*r.x,m=Math.pow(1-o,2)*n.y+2*o*(1-o)*s.y+Math.pow(o,2)*r.y,p=Math.abs(e-a),f=Math.abs(t-m),g=p+f;(!d||d>g)&&(d=g),h[i]=Math.max(p,f),c[i]=a,u[i]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const s=Math.hypot(c[n]-e,u[n]-t);(!p||p>s)&&(p=s)}return p}getLineLength(e,t,n,s){return Math.sqrt(Math.pow(n-e,2)+Math.pow(s-t,2))}getPointOnDistance(e,t,n,s,r,i){const o=n-r*((n-e)/i),l=s-r*((s-t)/i);return new a.Point(o,l)}findControlPoint(e,t,n,s,r,i){const o=t+(s-t)/2,l=n+(r-n)/2;let c=o-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(o+d/2*u,l-d/2*c):new a.Point(o-d/2*u,l+d/2*c)}canvasArrow(e,t,n,s,r){const i=Math.atan2(s-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(i-Math.PI/10),n-this.arrowWidth*Math.cos(i-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(i+Math.PI/10),n-this.arrowWidth*Math.cos(i+Math.PI/10))}}const W="dimensionality-reducer-terminate-event";var Y,Z,q=n(850);async function K(e,t,s,r,o,a,l){let c=await async function(e,t,s,r,o,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(42),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:s,options:a,weights:r,aggregationMethod:o});const d=i.events.onCustomEvent(W).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:s}})=>{k(n)||k(s)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,s,t)}}))}(e,s,t,r,o,a,l);return c=c.map((e=>(0,q.Fv)(e))),c}(Z=Y||(Y={})).EUCLIDEAN="EUCLIDEAN",Z.MANHATTAN="MANHATTAN";const z={[Y.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[Y.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var X,J;(J=X||(X={})).HAMMING="Hamming",J.EUCLIDEAN="Euclidean",J.MANHATTAN="Manhattan",J.TANIMOTO="Tanimoto",J.LEVENSTEIN="Levenshtein",J.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",J.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",J.SOKAL="Sokal",J.COSINE="Cosine",J.ASYMMETRIC="Asymmetric",J.Difference="Difference",J.OneHot="One-Hot";const Q={[X.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[X.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[X.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[X.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[X.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[X.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapOpenPenalty + f32(i - 1) * gapExtensionPenalty;\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapOpenPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n \n `},[X.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[X.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[X.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[X.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[X.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[X.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},ee={[X.HAMMING]:e=>Math.ceil(e/30),[X.EUCLIDEAN]:e=>Math.ceil(e/30),[X.MANHATTAN]:e=>Math.ceil(e/30),[X.TANIMOTO]:e=>Math.ceil(e/60),[X.SOKAL]:e=>Math.ceil(e/60),[X.COSINE]:e=>Math.ceil(e/60),[X.ASYMMETRIC]:e=>Math.ceil(e/60),[X.LEVENSTEIN]:e=>Math.ceil(e*e/60),[X.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[X.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[X.Difference]:e=>1,[X.OneHot]:e=>Math.ceil(e/40)},te={STRING:new Set([X.HAMMING,X.LEVENSTEIN,X.NEEDLEMAN_WUNSCH,X.MONOMER_CHEMICAL_DISTANCE,X.OneHot]),UINT32ARRAY:new Set([X.HAMMING,X.EUCLIDEAN,X.MANHATTAN,X.MONOMER_CHEMICAL_DISTANCE,X.LEVENSTEIN,X.NEEDLEMAN_WUNSCH,X.TANIMOTO,X.COSINE,X.SOKAL,X.ASYMMETRIC,X.OneHot,X.Difference]),INT32ARRAY:new Set([X.EUCLIDEAN,X.MANHATTAN,X.OneHot,X.Difference]),FLOAT32ARRAY:new Set([X.EUCLIDEAN,X.MANHATTAN,X.Difference]),NUMBER:new Set([X.EUCLIDEAN,X.MANHATTAN,X.Difference]),BITARRAY:new Set([X.TANIMOTO,X.COSINE,X.SOKAL,X.ASYMMETRIC])};var ne=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function se(e,t,n,s){return e.map(((e,s)=>`\n fn distanceScript${s}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${s}[aIndex];\n let b = computeInfo.data${s}[bIndex];\n let maxDistance: f32 = ${n};\n ${Q[e](t[s],s)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${z[s](e.length)}\n }\n \n `}let re=0;const ie="cliffsDf",oe=new u.Subject,ae="activity_difference",le="SALI_index",ce="similarity",ue="line_index",he=["1_molecule","2_molecule"],de="filterCliffs";async function me(e,t,s,r,l,c,u,h,d,m,p,f,g,y,b,v){re++;const w=c/100;let C,A=!1;const S=f.inputs,x=await f.apply({[S[0].name]:t,[S[1].name]:u,...d.preprocessingFuncArgs??{}});let _=[];if(h===N){const t=await function(e,t,s,r,i,o,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(231),n.b));let h;return u.postMessage({data:e,threshold:t,weights:s,aggregationMethod:r,distanceFns:i,distanceFnArgs:o,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([x.entries],c,[1],"MANHATTAN",[u],[x.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),_=[t.embedX,t.embedY]}else _=await K([x.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[x.options??{}]});if(_.length!==s.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<_.length;++t)e.columns.addNewFloat(s[t]).init((e=>_[t][e]));let M=null;if(d.useWebGPU)try{M=await function(e,t=.8,n,s,r,i){return ne(this,void 0,void 0,(function*(){const o=yield function(){return E(this,void 0,void 0,(function*(){if(!T&&(T=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==T))return null;let e=!1;if(I&&(I.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!I||e){const e=1e9,t=T.limits,n=t.maxBufferSize,s=t.maxStorageBufferBindingSize;try{return I=yield T.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(s,e)}}),I}catch(e){return console.error("Failed to create device with required limits",e),I=yield T.requestDevice(),I}}return I}))}();if(!o)return null;const a=Object.values(X);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(Y).includes(s))throw new Error("Invalid aggregation function provided: "+s);const l=1-t;if(i.length!==e.length||i.length!==n.length||i.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=X.HAMMING,n,s={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,i;let o=null;const a=e.some((e=>"string"==typeof e))?(o="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(o="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(o="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(o="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(o="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(o="INT32ARRAY",e):void 0;if(!a||!o)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!te[o]||!te[o].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${o}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=ee[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach(((e,t)=>{m.set(e,t*u)}));let p="",f=0,g="FLOAT32ARRAY",y=null;if(t===X.NEEDLEMAN_WUNSCH||t===X.MONOMER_CHEMICAL_DISTANCE){let e=s.scoringMatrix&&s.alphabetIndexes?Object.keys(s.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!s.alphabetIndexes||!s.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);s.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),s.alphabetIndexes={};for(let e=0;e<s.scoringMatrix.length;e++)s.scoringMatrix[e][e]=1,s.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),o=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)o[t][t]=1;const a=s.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(o[e.charCodeAt(0)][t.charCodeAt(0)]=s.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=s.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(i=s.gapExtensionPenalty)&&void 0!==i?i:.6;let l=2;for(let e=0;e<o.length;e++)y.set(o[e],l),l+=o[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===X.Difference){if(!s.range||"number"!=typeof s.range||s.range<=0){const e=m.reduce(((e,t)=>Math.min(e,t)),m[0]),t=m.reduce(((e,t)=>Math.max(e,t)),m[0]);s.range=t-e}s.range<=0&&(s.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([s.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:p,entryType:o,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,i[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(s=Y.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*u);h.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(1e4/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/g),x=o.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${se(n,h.map((e=>e.maxEntryLen)),l,s)}\n\n\n `}),_=o.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),M=new Uint32Array(g),$=new Uint32Array(g),N=new Uint32Array(g),L=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),s=t-u*n+Math.floor((n+1)*(n+2)/2);M[e]=O,$[e]=R,N[e]=s,L[e]=n,R=n,O=s}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),D=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const V=15&G;0!==V&&(B+=16-V);const U=o.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),H=U.getMappedRange();let j=0;new Uint32Array(H,j,g).set(M),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set($),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set(N),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set(L),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,f.length).set(f),j+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(H,j,c).set(r),j+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(H,j,n).set(e.flatSourceArray),j+=n*t.BYTES_PER_ELEMENT}U.unmap();const W=D*Uint32Array.BYTES_PER_ELEMENT;let Z=W;const q=15&W;0!==q&&(Z+=16-q),Z=Math.max(Z,16);const K=o.createBuffer({label:"supp info buffer",size:Z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),z=K.getMappedRange();let J=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(z,J,e.suppInfoBuffer.length).set(e.suppInfoBuffer),J+=e.suppInfoBuffer.byteLength);0===J&&new Uint32Array(z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ne=Q;const re=15&Q;0!==re&&(ne+=16-re);const ie=o.createBuffer({label:"results buffer",size:ne,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),oe=o.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:_.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:U}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:ie}}]}),ae=o.createBuffer({label:"results out buffer",size:ie.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=o.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(_),t.setBindGroup(0,oe),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(ie,0,ae,0,ae.size);const n=e.finish();o.queue.submit([n]),yield o.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const s=ae.getMappedRange();let r=0;const i=new Uint32Array(s,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(s,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(s,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(s,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(s,r,g).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(i.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),me=new Uint32Array(de),pe=new Uint32Array(de),fe=new Float32Array(de);let ge=0;for(let e=0;e<le.length;e++)me.set(le[e],ge),pe.set(ce[e],ge),fe.set(ue[e],ge),ge+=le[e].length;return U.destroy(),K.destroy(),ie.destroy(),ae.destroy(),{i:me,j:pe,distance:fe}}))}([x.entries],w,[u],Y.MANHATTAN,[1],[x.options??{}])}catch(e){console.error(e)}M||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),M=await(new B).calc(x.entries,u,w,x.options));const $=await async function(e,t){const n=e.distance.map(((n,s)=>{const r=Math.abs(t.get(e.i[s])-t.get(e.j[s]));return 0!=n?r/n:1/0})),s=e.distance.map((e=>1-e)),r=e.i,i=e.j,o=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{o.set(e.i[n],!0),o.set(e.j[n],!0)})),{simVals:s,saliVals:n,n1:r,n2:i,cliffsBitSet:o}}(M,l),L=function(e,t,n,s,r,i,o){const l=new Array(e).fill(0);for(let e=0;e!=s.length;++e)n[e]!=1/0&&(o.get(s[e])>o.get(r[e])?l[s[e]]+=n[e]:l[r[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${s[0].substring(s[0].lastIndexOf("_"))}`,$.saliVals,$.n1,$.n2,0,l);e.columns.add(L);const P=$.cliffsBitSet,O=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}($.saliVals),k=.8/(O.max-O.min),D=i.shell.getTableView(e.name),F=D.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:s[0],yColumnName:s[1],size:L.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),G=function(e,t,n,s,r,i,o,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-o.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return he.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),i),u.col(e).semType=r})),u.columns.addNewFloat(ae).init((e=>Math.abs(s.get(c.from[e])-s.get(c.to[e])))),u.columns.addNewInt(ue).init((e=>e)),u.columns.addNewFloat(le).init((e=>t.saliVals[e])),u.columns.addNewFloat(ce).init((e=>t.simVals[e])),u.name=`${ie}${re}`,{lines:c,linesDf:u}}(e,$,t,l,m,p,O,k);G.lines.skipMultiLineCalculation=!0,G.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(F,s[0],s[1],G.lines,V.none),H=b?b(G.linesDf,he).sort([le],[!1]):G.linesDf.plot.grid().sort([le],[!1]);H.col(ue)&&(H.col(ue).visible=!1),e.temp[".cliffsDfGrid"]=H;const W=o.button(`${G.linesDf.rowCount} cliffs`,(()=>{D.dockManager.dock(H,"down",null,"Activity cliffs",v??.2)}));W.classList.add("scatter_plot_link","cliffs_grid"),F.root.append(W);const Z=o.switchInput("Show only cliffs",!1,(()=>{Z.value?(F.dataFrame.setTag(de,s[0]),e.filter.and(P),oe.next(s[0])):(F.dataFrame.setTag(de,""),e.filter.setAll(!0),oe.next(""))}));Z.root.classList.add("scatter_plot_link","show_only_cliffs"),F.root.append(Z.root),oe.subscribe((e=>{Z.enabled=""===e||e===s[0]}));let q=!1;F.onEvent("d4-before-draw-scene").subscribe((t=>{q?q=!1:Z.value&&(setTimeout((()=>{e.filter.and(P)}),100),q=!0)}));const z=i.events.onViewerClosed.subscribe((e=>{e.args.viewer===F&&(D.dockManager.close(H.root),z.unsubscribe(),D.subs=D.subs.filter((e=>e!==z)))}));return D.subs.push(z),G.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<G.linesDf.rowCount;e++)G.lines.widths[e]=e===G.linesDf.currentRowIdx?3:1;U.linesToRender=G.lines;const n=G.linesDf.currentCol&&G.linesDf.currentCol.name===he[1]?G.lines.to:G.lines.from,r=-1!==G.linesDf.currentRowIdx?G.linesDf.currentRowIdx:null;if(F.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=G.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,s,r,i){const o=Math.abs(n-r),a=Math.abs(s-i),l=e/o,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<r?n:r)+o/2-h/2,p=(s>i?s:i)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(F.viewport.width,F.viewport.height,F.dataFrame.get(s[0],G.lines.from[n]),F.dataFrame.get(s[1],G.lines.from[n]),F.dataFrame.get(s[0],G.lines.to[n]),F.dataFrame.get(s[1],G.lines.to[n]));F.zoom(a,u,c,h),Z.value?e.filter.and(P):!0===Z.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,s,r,a,l,c,u){const h=t.getPane("Cliff Details");o.empty(h.root);const d=u({points:[n,s],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{i.shell.o=t.root}),500)}(e,C,G.lines.from[r],G.lines.to[r],r,t,l,G.linesDf.get(le,r),y);const n=F.dataFrame.getSortedOrder(D.grid.sortByColumns,D.grid.sortTypes);D.grid.scrollToCell(t.name,n.indexOf(F.dataFrame.currentRowIdx))}),1e3)}})),G.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<G.linesDf.rowCount;e++){const n=G.linesDf.selection.get(e);n&&(t.set(G.lines.from[e],!0),t.set(G.lines.to[e],!0)),G.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),U.linesToRender=G.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<G.lines.colors.length;e++)G.lines.colors[e]="0,128,0";U.linesToRender=G.lines})(H.dataFrame))})),U.lineClicked.subscribe((t=>{if(A=!0,U.currentLineId=t.id,-1!==t.id){const n=G.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),G.linesDf.selection.copyFrom(n)):(G.linesDf.currentRowIdx!==t.id&&(G.linesDf.currentRowIdx=t.id,e.currentRowIdx=G.lines.from[t.id]),G.linesDf.selection.copyFrom(n));const s=G.linesDf.getSortedOrder(H.sortByColumns,H.sortTypes);H.scrollToCell(he[0],s.indexOf(t.id))}),500)}})),U.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(g({lineId:n.id,points:[G.lines.from[n.id],G.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),F.addProperty("similarityLimit","double",w),C=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),i.shell.o=e.root,e}(),F}var pe,fe=n(8447),ge=n(8607),ye=n(5226),be=n(7228),ve=n(8457);async function we(e,t,n,s){const r=(0,ve.O)(t),i=ge.g.forColumn(t).getNewColumnFromList("ref",[n]),o=ge.g.forColumn(i).getSplitted(0),l=s===pe.IDENTITY?function(e,t){const n=t.columns.length,s=new Array(n),r=new Array(n),i=new Array(n);for(let o=0;o<n;++o){const n=t.columns.byIndex(o);s[o]=n.getRawData(),r[o]=n.categories.indexOf(""),i[o]=n.categories.indexOf(e.getOriginal(o)??"")}const o=a.Column.float("Identity",t.rowCount),l=o.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)s[t][n]===i[t]&&++l[n];l[n]/=e.length}return o}(o,r):s===pe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,be.Qx)(n,e)}(o,r):null;if(null===l)throw new Error(`In bio library: Unkown sequence scoring method: ${s}`);return l.name=e.columns.getUnusedName(l.name),e.columns.add(l),l}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var Ce=n(7945),Ae=n(4293),Se=n(6414),xe=n.n(Se),Ee=n(8260);const Te="#808080",Ie="rgb(0,0,0)",_e=Ee.GU;var Me,$e;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(Me||(Me={})),function(e){e.MSA="MSA",e.classic="classic"}($e||($e={}));const Ne=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=$e.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function Le(e,t,n,s,r,i,o){var a,l,c;const u=Object.assign(Object.assign({},Ne),o);o.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let h=t.substring(0),d=u.last?"":u.separator;u.drawStyle===$e.MSA&&(d="");let m=!0,p=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(m=u.gridCell.cell.column.temp["color-code"]??!0,p=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];p&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=h==e?.3:u.transparencyRate),p&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=h!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(h=_e(h,u.maxLengthOfMonomer));const g=h+d;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));let b=u.monomerTextSizeMap[h].width;const v=i/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));const w=u.monomerTextSizeMap[d].width;function C(t,r){const i=m?u.color:Ie;e.fillStyle=i,e.globalAlpha=u.transparencyRate,u.drawStyle===$e.classic&&(e.fillText(h,n+t,s+v),e.fillStyle=Te,e.fillText(d,n+r,s+v)),u.drawStyle===$e.MSA&&e.fillText(h,n+t,s+v)}y=y.width,u.drawStyle===$e.MSA&&(b=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const A=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>r)return C(A,A+b),n+A+b+w;{const e=(r-y)/2;return C(e,e+b),n+A+e+b}}var Pe=n(9611),Re=n(7331);const Oe={[fe.fb.DNA]:"RNA",[fe.fb.RNA]:"RNA",[fe.fb.PT]:"PEPTIDE",[fe.fb.UN]:"PEPTIDE"};var ke,De=n(9713);!function(e){e.long="long",e.short="short"}(ke||(ke={}));const Fe={true:"1",false:"0"};var Ge=n(3553);const Be="rgb(100,100,100)",Ve=fe.GU;function Ue(e,t,n,s,r){return e?Math.max(Math.min(e.canvas.width/r-n,s)):Math.max(t.canvas.width/r-n,0)}function He(e){const t=!xe().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],s=t?"":" ";for(const[t,r]of xe().enumerate(e)){let i=t;r<e.length&&(i+=`${t?"":"-"}${s}`),n.push(i)}return[n,t]}class je extends a.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const[n,s,r]=(0,De.N)(e),i=r.rendererBack;if(!i)return;const a=e.bounds,l=t.offsetX-e.gridColumn.left+(e.gridColumn.left-a.x),c=i.getPosition(e.tableRowIndex,l,a.width),u=ge.g.forColumn(s).getSplitted(e.tableRowIndex).canonicals;if(null!==c&&c<u.length){const e=u[c],n=[];let r=i._monomerStructureMap[e];r=i._monomerStructureMap[e]=(()=>{const t=ge.g.forColumn(s).alphabet??fe.fb.UN,n=Oe[t],r=ws();return r?r.getTooltip(n,e):o.divText("Monomer library is not available")})(),n.push(r),o.tooltip.show(o.divV(n),t.x+16,t.y+16)}else o.tooltip.hide()}render(e,t,n,s,r,i,o){const l=window.devicePixelRatio,[c,u,h]=(0,De.N)(i);if(!u)return;const d=u.temp;let m=0,p=50;const f=d["monomer-width-mode"];if("short"===(null!=f?f:ds.properties?.MonomerWidthMode??ke.short)){const e=parseInt(u.getTag(Me.maxMonomerLength));p=(isNaN(e)?ds.properties?.MaxMonomerLength:e)??4}const[g,y,b]=(0,De.N)(i);let v=b.rendererBack;v||(v=b.rendererBack=new Pe.A(c,u,ds.logger,p,(()=>{const e=ge.g.forColumn(u);return{seqHandler:e,monomerCharWidth:7,separatorWidth:e.isMsa()?8:m,monomerToShort:Ve}}))),e.save();try{u.tags[".mm.cellRenderer.settingsChanged"]!==Fe.true&&v.monomerLengthLimit==p||(m=d[".mm.cellRenderer.gapLength"]??m,v.setMonomerLengthLimit(p),v.setSeparatorWidth(v.isMsa()?8:m),u.setTag(".mm.cellRenderer.settingsChanged",Fe.false));const[o,h]=v.getCellMonomerLengths(i.tableRowIndex,s),f=(o.length,i.cell.value,i.cell.rowIndex),g=u.getTag(fe.DX.alphabet),y=50;s=Ue(c?.grid,e,t,s,l),e.beginPath(),e.rect(t+this.padding,n+this.padding,s-this.padding-1,r-2*this.padding),e.clip(),e.font="12px monospace",e.textBaseline="top";const b=u.getTag(a.TAGS.UNITS),w=u.getTag(fe.DX.aligned),C=(0,fe.py)(g),A=u.getTag(fe.DX.separator)??"",S=v.props.separatorWidth+1*v.props.monomerCharWidth,x=Math.ceil(s/S),E=ge.g.forColumn(u),T=d["reference-sequence"],I=d["current-word"];I&&-1===u?.dataFrame?.currentRowIdx&&(d["current-word"]=null);const _=(()=>{const e=E.getSplitter(x);return xe()(e(null!=T&&""!=T?T:I??"").originals).toArray()})(),M=E.getSplitted(f);let $=Be,N=$e.classic;w&&w.includes("MSA")&&b==fe.r2.SEPARATOR&&(N=$e.MSA);const L=Math.min(M.length,x);for(let o=0;o<L;++o){const a=M.getOriginal(o);$=C.get(a),e.fillStyle=Be;const l={color:$,pivot:0,left:!0,transparencyRate:1,separator:A,last:o===M.length-1,drawStyle:N,maxWord:h,wordIdx:o,gridCell:i,referenceSequence:_,maxLengthOfMonomer:p,monomerTextSizeMap:v._monomerLengthMap,logger:ds.logger};if(Le(e,a,t+this.padding,n,s,r,l),y>s)break}}catch(e){const[t,n]=(0,Ce.yf)(e);v.logger.error(t,void 0,n),v.errors.push(e)}finally{e.restore()}}}class We extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Ge.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,s,r,i,o){const l=window.devicePixelRatio,c=i.grid,u=i.cell,h=i.tableColumn,d=u.value??"",m=h.tags[fe.DX.separator],p=h.tags[a.TAGS.UNITS];s=Ue(c,e,t,s,l);const[f,g]=d.split("#"),y=(0,Ee.vU)(p,m);Ye(e,t,n,s,r,xe()(y(f).canonicals).toArray(),xe()(y(g).canonicals).toArray(),p)}}function Ye(e,t,n,s,r,i,o,a,l,c){if(i.length!==o.length){const e=function(e,t){let n=0,s=0;const r=e.length>t.length?e:t,i=e.length>t.length?t:e;for(let e=0;e<i.length;e++)r[e]===i[e]&&n++;const o=r.length-i.length;for(let e=r.length-1;e>o;e--)r[e]===i[e-o]&&s++;const a=new Array(Math.abs(e.length-t.length)).fill(ge.lh[fe.r2.FASTA]);function l(e){return n>s?e.concat(a):a.concat(e)}return e.length>t.length?t=l(xe()(t).toArray()):e=l(xe()(e).toArray()),{subParts1:e,subParts2:t}}(i,o);i=e.subParts1,o=e.subParts2}const u=e.measureText(He(i).join("")),h=e.measureText(He(o).join("")),d=Math.max(u.width,h.width);l&&(s=d+4*i.length,e.canvas.width=d+4*i.length);let m=Math.max(t,t+(s-(d+4*i.length))/2)+5;const p=Math.max(n,n+(r-28)/2);e.save(),e.beginPath(),e.rect(t,n,l?d+4*i.length:s,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Re.UE.Color;"HELM"!=a&&(f=(0,fe.py)(a.substring(a.length-2)));for(let t=0;t<i.length;t++){const n=i[t],a=o[t],l=f.get(n);if(n!=a){const i=f.get(a),o=Le(e,n,m,p-7,s,r,{color:l,pivot:0,left:!0}),u=Le(e,a,m,p+7,s,r,{color:i,pivot:0,left:!0});m=Math.max(u,o),c&&(c[t]=Ze(n,a,l,i,p,7,r))}else m=Le(e,n,m,p,s,r,{color:l,pivot:0,left:!0,transparencyRate:.5});m+=4}e.restore()}function Ze(e,t,n,s,r,i,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(He([e]).join("")).width,u=l.measureText(He([t]).join("")).width,h=Math.max(c,u);return a.height=o,a.width=h+4,l.font="12px monospace",l.textBaseline="top",Le(l,e,0,r-i,h,o,{color:n,pivot:0,left:!0}),Le(l,t,0,r+i,h,o,{color:s,pivot:0,left:!0}),a}var qe,Ke=n(2997),ze=n(9298);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(qe||(qe={}));const Xe=new class{constructor(){this.regionTypes=[qe.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=ze.ES.Entropy,this.filterSource=ze.vS.filterSource}};var Je=n(172),Qe=n(8415);const et=qe;var tt,nt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(tt||(tt={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(nt||(nt={}));const st=Xe;class rt extends a.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewerId=++rt.viewerCounter,this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this._onRendered=new u.Subject,this.skipEmptyPositions=this.bool(nt.skipEmptyPositions,st.skipEmptyPositions,{category:tt.DATA}),this.regionTypes=this.stringList(nt.regionTypes,st.regionTypes,{category:tt.DATA,choices:Object.values(et).filter((e=>e!=et.Unknown))}),this.chains=this.stringList(nt.chains,st.chains,{category:tt.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(nt.fitWidth,st.fitWidth,{category:tt.LAYOUT}),this.positionWidth=this.float(nt.positionWidth,st.positionWidth,{category:tt.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(nt.positionHeight,st.positionHeight,{category:tt.LAYOUT,choices:Object.keys(ze.ES)}),this.filterSource=this.string(nt.filterSource,st.filterSource,{category:tt.BEHAVIOR,choices:Object.values(ze.Ct)}),this.viewSyncer=new Je.c(ds.logger)}viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case nt.regionTypes:case nt.chains:this.setData(this.regions)}switch(e.name){case nt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[Qe.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case nt.fitWidth:case nt.positionWidth:this.calcSize();break;case nt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[Qe.bo.positionHeight]:this.positionHeight});this.calcSize();break;case nt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;ds.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}async destroyView(e){ds.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&o.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){ds.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),s=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const i=t.find((t=>t.order==n[e]&&t.chain==r));s.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:i.sequenceColumnName,startPositionName:i.positionStartName,endPositionName:i.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(s);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=o.table(this.chains,(e=>[...n.length>0?[o.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",o.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=o.choiceInput("Data source",this.filterSource,Object.values(ze.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=o.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),ds.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){ds.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,s=9,r=(this.root.clientWidth-e-(this.logos.length-1)*s-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[Qe.bo.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[Qe.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(nt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[Qe.bo.filterSource]:this.filterSource})}}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,Ke.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}rt.viewerCounter=-1;var it=n(9017),ot=n(708);async function at(e,t,n="Morgan"){const s=e.length,r=ge.g.forColumn(e),i=Array(s);let o=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<s;t++){if(null===l[c[t]]||e.isNone(t)){i[t]=null;continue}i[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const s=n.getCanonical(e);a.has(s)||(a.set(s,String.fromCharCode(o)),o++),i[t]+=a.get(s)}}let u={};if(t===ot.U.MONOMER_CHEMICAL_DISTANCE||t===ot.U.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,be.GR)(e,n),s={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{s[a.get(e)]=t})),u={scoringMatrix:t.scoringMatrix,alphabetIndexes:s}}return{seqList:i,options:u}}var lt=n(6361),ct=n(7983);function ut(e){const t=o.divH([],{style:{gap:"10px"}}),n=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const s=o.divText(e.activityCol.get(n).toFixed(2));s.style.display="flex",s.style.justifyContent="left",s.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(n)),s]))})),t}function ht(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,s)=>{n[s]=e.activityCol.get(t)}));const s={},r=ge.g.forColumn(e.seqCol),i=mt(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),r.units,s);return t.append(o.div(i,{style:{width:"300px",overflow:"scroll"}})),t.append(pt(s)),t.append(dt("Activity delta",Math.abs(n[0]-n[1]))),t.append(dt("Cliff",e.sali)),t}function dt(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function mt(e,t,n,s){const r=document.createElement("canvas"),i=r.getContext("2d");return r.height=30,Ye(i,0,0,0,30,xe()(e.canonicals).toArray(),xe()(t.canonicals).toArray(),n,!0,s),r}function pt(e){const t=o.div();if(Object.keys(e).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function ft(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(a.TAGS.UNITS,e.col(t[0]).getTag(a.TAGS.UNITS)),n.setTag(fe.DX.separator,e.col(t[0]).getTag(fe.DX.separator)),e.columns.add(n);const s=e.plot.grid();return s.col(t[0]).visible=!1,s.col(t[1]).visible=!1,s}class gt extends a.JsViewer{constructor(e){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[a.TAGS.UNITS,fe.DX.aligned,fe.DX.separator,fe.DX.alphabet],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",O.kg[0],{choices:O.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(o.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var yt=n(7241),bt=n(1821);const vt={gapPenalty:1,matchScore:1,gapSymbol:ge.lh[bt.r2.FASTA],localAlignment:!1};class wt extends gt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new u.Subject,this.distanceMatrixComputed=!1,this.kPrevNeighbors=0,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=ge.g.forColumn(this.moleculeColumn);await(e.isHelm()?this.computeByChem():this.computeByMM());const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=a.Column.string(t,this.idxs.length).init((e=>this.moleculeColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.moleculeColumn.getTag(e))));const n=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const s=n.plot.grid();s.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));s.cell("score",r).cell.value=null,i.shell.v.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),(0,Ae.Y)(this.root,s.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,yt.D)(this.moleculeColumn),t=(a.DataFrame.fromColumns([e]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:e,molecule:e.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=t.getCol("indexes"),this.scores=t.getCol("score")}async computeByMM(){const e=this.moleculeColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await at(this.moleculeColumn,ot.U.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new B).getKNN(n,ot.U.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=o.div(),n={},s=this.molCol?.name,r=e.col(s),a=ge.g.forColumn(this.moleculeColumn),l=ge.g.forColumn(r),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const s={...vt,...n},r=e.length,i=t.length,o=Array(r+1).fill(0).map((()=>Array(i+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<i+1;r++)o[n][r]=Math.max(0,o[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?s.matchScore:-s.matchScore),o[n-1][r]-s.gapPenalty,o[n][r-1]-s.gapPenalty),o[n][r]>=a&&(a=o[n][r],l=[n,r]);let c=s.localAlignment?l[0]:r,u=s.localAlignment?l[1]:i,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(o[c-1][u-1],o[c-1][u],o[c][u-1]);o[c][u]==o[c-1][u-1]+s.matchScore&&n==o[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):o[c][u]==o[c-1][u]-s.gapPenalty?(d.push(s.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):o[c][u]==o[c][u-1]-s.gapPenalty?(h.push(s.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...Array.from(e.canonicals).splice(0,c),...h.reverse(),...s.localAlignment?Array.from(e.canonicals).splice(l[0],r):[]],d=[...Array.from(t.canonicals).splice(0,u),...d.reverse(),...s.localAlignment?Array.from(t.canonicals).splice(l[1],i):[]];const m=c,p=u;return m>p?d=[...new Array(m-p).fill(s.gapSymbol.valueOf()),...d]:h=[...new Array(p-m).fill(s.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(s.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(s.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Ee.wx(h,s.gapSymbol),seq2Splitted:new Ee.wx(d,s.gapSymbol)}}(c,u),d=mt(h.seq1Splitted,h.seq2Splitted,l.units,n);t.append(o.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(o.divV([o.divText("Different sequence length:",{style:{fontWeight:"bold"}}),o.divText(`target: ${c.length} monomers`),o.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(pt(n));const m=o.accordion(),p=o.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(o.span([p,o.label("Similarity search")])),m.addPane("Differences",(()=>t),!0),i.shell.o=m.root}}var Ct=n(279);class At extends gt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new u.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.moleculeColumn){const e=ge.g.forColumn(this.moleculeColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.moleculeColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.moleculeColumn.getTag(e))));const s=a.DataFrame.fromColumns([n]);s.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[s.currentRowIdx]})),(0,Ae.Y)(this.root,s.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,yt.D)(this.moleculeColumn);a.DataFrame.fromColumns([e]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await at(this.moleculeColumn,ot.U.LEVENSHTEIN)).seqList,t=new G(!0,!1),n=await t.calc(e,ot.U.LEVENSHTEIN);t.terminate();const s=this.moleculeColumn.length,r=(0,F.y)(s);this.renderMolIds=(0,Ct.L)(s,Math.min(s,this.limit),((e,t)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(t)?0:n[r(e,t)]))}}var St,xt=n(4004),Et=n(9943),Tt=n(5393),It=n(6584);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(St||(St={}));class _t{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const s=this.isWhitespace(n)?t:t-1;for(let e=0;e<s;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let s=0;s<e;s++)n=this.shiftIdxToAtomType(n),t[s]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let s=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){s=this.shiftIdxToXColumn(s);for(const i of[e,t,n])i[r]=this.parseFloatValue(s),s=this.getNextColumnIdx(s);s=this.getNextLineIdx(s)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const s=new Uint16Array(2);s[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),s[1]=this.parseIntValue(t),e[n]=s,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let s=0;s<e;s++)n=this.shiftIdxToBondType(n),t[s]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class Mt extends _t{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let s=0;s<t;s++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class $t extends Mt{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(St.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,s]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,s)}}));const n=t.map(((e,t)=>{if(e.startsWith(St.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),s=n.map((e=>t[e])),r=n.map((e=>t[e+1]));s.forEach(((t,n)=>{const s=parseInt(t.split(/\s+/)[1])-1,i=parseInt(r[n].substring(1));if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,s)}));const i=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==i.length)throw new Error(`Unaccounted R group indices: ${i}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(St.TYPE)&&-1!==e.indexOf(St.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,St.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<St.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,St.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,St.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+St.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=St.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends Mt{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const s=t.match(/RGROUPS=\(([\d\s]+)\)/);if(s){const t=s[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Lt{constructor(){}static getInstance(e){if(Lt.isMolfileV2K(e))return new $t(e);if(Lt.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return $t.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Pt=n(8277),Rt={};Rt.styleTagTransform=A(),Rt.setAttributes=b(),Rt.insert=g().bind(null,"head"),Rt.domAPI=p(),Rt.insertStyleElement=w(),d()(Pt.Z,Rt),Pt.Z&&Pt.Z.locals&&Pt.Z.locals;class Ot{constructor(e,t=undefined,n=undefined){this.source=t,this.error=n,this._monomers={},this._onChanged=new u.Subject,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let s=t;return t===ge.lh[fe.r2.HELM]?s="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(s="Any"),n[t]={symbol:t,name:s,molfile:"",author:"MISSING",id:-1,rgroups:xe().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let s=null;if(e){const t=this._monomers[e];s=t?t[n]:null}else{ds.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(s=t[n],s)break}return s}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let s=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return s=s.filter((e=>null!==e)),0===s.length?[]:(s=s.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;return Lt.getInstance(t.molfile).atomTypes.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&(n=!0),n})),s.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={});for(const t of e)t.error||this._updateInt(t);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,s]of xe().enumerate(e))t[s]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=o.div([],{classes:"ui-form ui-tooltip"}),s=this.getMonomer(e,t);if(s){const e=s.symbol;s.name,n.append(o.divH([o.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),o.div([s.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let r;r=s.molfile?i.chem.svgMol(s.molfile,void 0,void 0,t):s.smiles?o.divV([i.chem.svgMol(s.smiles,void 0,void 0,t),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),n.append(o.div(r,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(o.divText(s.lib?.source??"Missed in libraries"))}else n.append(o.divV([o.divText(`Monomer '${t}' of type '${e}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}var kt=n(5128),Dt=n.n(kt),Ft=n(3351),Gt=n.n(Ft);class Bt{constructor(e){this.helmMonomerSchema=e;const t=new(Dt())({allErrors:!0,strictTuples:!1});Gt()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;for(const s of e){const e=s.symbol??s.id??s.name??"#N/A";if(n=this.validateMonomerSchema(s),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,s,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}}return n}}class Vt{constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.filesPromise=Promise.resolve(),this.objId=++Vt.objCounter,this.eventManager.updateValidLibraryFileListRequested$.subscribe((async()=>{await this.updateValidLibraryList()}))}toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t){const n=await i.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),s=JSON.parse(n),r=new Bt(s);return new Vt(r,e,t)}async addLibraryFile(e,t){try{if(await this.libraryFileExists(t))return void i.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await i.dapi.files.writeAsText(It.BX+`${t}`,e),await this.updateValidLibraryList(),await i.dapi.files.exists(It.BX+`${t}`)?i.shell.info(`Added ${t} HELM library`):i.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),i.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await i.dapi.files.delete(It.BX+`${e}`),await this.updateValidLibraryList(),i.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await i.dapi.files.exists(It.BX+`${e}`)?i.shell.error(`Failed to delete ${e} library`):i.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const s=new a.FileSource(e),r=await s.readAsText(t);n=JSON.parse(r);const i={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(i[t]={},o.push(t)),i[t][n]=e})),new Ot(i,t)}getValidLibraryPaths(){return this.eventManager.getValidFilesPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async libraryFileExists(e){return await i.dapi.files.exists(It.BX+`${e}`)}async updateValidLibraryList(){const e=`${this.toLog()}.updateValidLibraryList()`;return ds.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{ds.logger.debug(`${e}, IN`);const t=[],n=await this.getFilePathsAtDefaultLocation();if(!this.fileListHasChanged(n))return void ds.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await i.dapi.files.readAsText(It.BX+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const s=n.filter((e=>!t.includes(e)));if(this.fileListHasChanged(s)&&(this.eventManager.changeValidFilesPathList(s),this.libHelper.loadLibraries(!0)),s.some((e=>!e.endsWith(".json")))&&ds.logger.warning(`Wrong validation: ${s}`),t.length>0){const e=`Invalid monomer library files in ${It.BX}, consider fixing or removing them: ${t.join(", ")}`;ds.logger.warning(e)}ds.logger.debug(`${e}, OUT`)}))}fileListHasChanged(e){const t=this.eventManager.getValidFilesPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getFilePathsAtDefaultLocation(){const e=(await i.dapi.files.list(It.BX)).map((e=>e.fullPath)),t=[];for(const n of e)await i.dapi.files.exists(n)&&t.push(n);return t.map((e=>e.substring(It.BX.length)))}}Vt.objCounter=-1;class Ut{constructor(){this._libraryFilesUpdateSubject$=new u.BehaviorSubject([]),this._addLibraryFilesSubject$=new u.Subject,this._librarySelectionSubject$=new u.Subject}static getInstance(){return Ut._instance||(Ut._instance=new Ut),Ut._instance}getValidFilesPathList(){return this._libraryFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{this._libraryFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((t=>{e(t)}))}))}changeValidFilesPathList(e){this._libraryFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Ht{get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,Ke.gw)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(){this._monomerLib=new Ot({},"MAIN"),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await Vt.create(this,this._eventManager))()),this._fileManagerPromise}async loadLibraries(e=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[t,n]=await Promise.all([(await this.getFileManager()).getValidLibraryPaths(),(0,It.nW)()]),s=t.filter((e=>{const t=!n.exclude.includes(e),s=0===n.explicit.length||n.explicit.includes(e);return t&&s})),r=await Promise.all(s.map((e=>this.readLibrary(It.BX,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Ot({},e,n)})))));this._monomerLib.updateLibs(r,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;i.shell.warning(t);const n=e instanceof Error?e.stack:void 0;ds.logger.error(t,void 0,n)}}))}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,It.nW)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,It.tW)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return void 0===e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new Ht;return e._eventManager=Ut.getInstance(),e})()),e}}var jt=n(3336),Wt=n.n(jt),Yt=n(8710),Zt={};async function qt(){await Xt.showDialog()}Zt.styleTagTransform=A(),Zt.setAttributes=b(),Zt.insert=g().bind(null,"head"),Zt.domAPI=p(),Zt.insertStyleElement=w(),d()(Yt.Z,Zt),Yt.Z&&Yt.Z.locals&&Yt.Z.locals;class Kt{get widget(){return this._widget}constructor(){}static async getInstance(){return void 0===Kt.instancePromise&&(Kt.instancePromise=(async()=>{const e=new Kt,t=await(0,be.JN)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),Kt.instancePromise}async createWidget(){const e=await this.getWidgetContent();return(await(0,be.JN)()).eventManager.addLibraryFileRequested$.subscribe((async()=>await this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await zt.createControlsForm();return Wt()(e).addClass("monomer-lib-controls-form"),o.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,s=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){i.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{s.close()}}})}}class zt{constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((async([e,t])=>{await this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){ds.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,be.JN)().then((e=>e.getFileManager())),await(0,It.nW)()]);return new zt(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=o.form(e);return Wt()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();Wt()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;ds.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),s=o.boolInput(e,n,(t=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,t)}));o.tooltip.bind(s.root,`Include monomers from ${e}`);const r=o.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e)));return o.tooltip.bind(r,`Delete ${e}`),s.addOptions(r),ds.logger.debug(`${t}, libFileName = '${e}', end`),s}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,It.tW)(this.userLibSettings);const n=await(0,be.JN)();await n.loadLibraries(!0),i.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){o.dialog("Warning").add(o.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),i.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class Xt{constructor(){this.closeDialogSubject$=new u.Subject}static async showDialog(){Xt._instance||(Xt._instance=new Xt,Xt._instance.closeDialogSubject$.subscribe((()=>{Xt._instance.dialog=void 0}))),Xt._instance.dialog||(Xt._instance.dialog=await Xt._instance.getDialog()),Xt._instance.dialog.show()}async getDialog(){const e=Ut.getInstance(),t=(await Kt.getInstance()).widget,n=o.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});return Wt()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t),n.onClose.subscribe((()=>this.closeDialogSubject$.next())),n}}var Jt,Qt=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};class en{constructor(e,t,n=!1,s){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==s?void 0:s.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,en.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=o.iconFA("clock");this._isAutomatic||0===t&&(n=o.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const s=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),i=o.divH([n,s],"grok-tutorial-entry");this._activity.append(i,r)}}_initRoot(){var e,t,n;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const s=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,s,""),(null===(t=null===(e=s.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=s.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return Qt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],s=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];s.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const i=n,a=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,i.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,s,a),yield(0,Ke.gw)(a));const l=o.iconFA("check");if(s.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Qt(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Qt(this,void 0,void 0,(function*(){const s=o.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const i=this._createSVGIndicator(r);s.append(i),e.prepend(s);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),s.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,en.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Qt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function tn(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;i.shell.error(t),ds.logger.error(e.message,void 0,n)}en.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Jt||(Jt={}));const nn="samples/FASTA_PT_activity.csv";async function sn(){const e="Dendrogram",t=a.Func.find({package:e,name:"getTreeHelper"});if(0===t.length)throw new Error(`Package "${e}" must be installed for TreeHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}async function rn(){return await i.functions.call("Dendrogram:getDendrogramService",{})}var on=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function an(e,t,s){return on(this,void 0,void 0,(function*(){return new Promise((function(r,i){const o=new Worker(new URL(n.p+n.u(356),n.b));o.postMessage({distMatArray:e,n:t,methodCode:s}),o.onmessage=({data:{error:e,clusterMatrix:t}})=>{o.terminate(),e?i(e):r(t)}}))}))}var ln,cn,un,hn=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};n(7905),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(ln||(ln={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(cn||(cn={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(un||(un={}));const dn="samples/FASTA_PT_activity.csv",mn="sequence";const pn="samples/FASTA_PT_activity.csv";var fn=n(8341);const gn="samples/HELM.csv";var yn=n(2568),bn=n(6098),vn=n(525);class wn{constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=xe()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${ds.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case Qe.bo.fixWidth:case Qe.bo.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Cn{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=o.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE),t={filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE};this.seqColInput=o.columnInput("Sequence",this.tableInput.value,e,null,t),this.funcParamsDiv=o.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=o.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE))}}var An=n(9416);class Sn{constructor(e){this.monomerLib=e}getCappedRotatedMonomer(e,t){const n=this.monomerLib.getMonomer(e,t);return n?n.molfile:null}}const xn=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},En={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class Tn{constructor(e){this.gridCol=e,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(e,t,n){if(e.grid.dart!=this.gridCol.grid.dart||e.gridColumn.dart!=this.gridCol.dart||!e.tableColumn||!e.isTableCell)return!1;const s=e.tableColumn.getTag(bt.DX.alphabet),r=e.cell.value,a=e.grid.canvas.getBoundingClientRect(),l=e.bounds.right+a.left-4,c=e.bounds.bottom+a.top-4,u=ws();if(!u)return o.tooltip.show(o.divText("Monomer library is not available."),l,c),!0;const h=new Sn(u),d=s===fe.fb.DNA||s===fe.fb.RNA?"RNA":(fe.fb.PT,"PEPTIDE"),m=h.getCappedRotatedMonomer(d,r),p=o.div(r),f=m?i.chem.svgMol(m,void 0,void 0,En):null;return o.tooltip.show(o.divV([p,...f?[f]:[]]),l,c),!0}static getOrCreate(e){let t=e.temp[xn.tooltipHandlerTemp];return t||(t=e.temp[xn.tooltipHandlerTemp]=new Tn(e)),t}}class In extends a.GridCellRenderer{get name(){return Ge.Of.MONOMER}get cellType(){return Ge.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,s,r,i,o){if(i.gridRow<0)return;Tn.getOrCreate(i.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,fe.py)(i.cell.column.getTag(bt.DX.alphabet)),l=i.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c,e.fillText((0,fe.GU)(l,6),t+s/2,n+r/2,s)}}class _n extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MonomerWidthMode(){return super.get("MonomerWidthMode")}set MonomerWidthMode(e){super.set("MonomerWidthMode",e),this._onPropertyChanged.next("MonomerWidthMode")}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(e){super.set("MaxMonomerLength",e),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e)),this._onPropertyChanged=new u.Subject}}class Mn extends a.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(e){this._properties=e}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Ce.yf)(e);i.shell.error(t),this.logger.error(t,void 0,n)}}var $n=n(8770);class Nn extends a.Widget{constructor(e){super(o.divV([])),this.viewed=!1,this.wlViewer=null,this.seqCol=e}async init(){const e=ge.g.forColumn(this.seqCol),t=ds.properties.TooltipWebLogo,n=this.seqCol.getTag(ze.DX.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function Ln(e,t,n,s){const r=ge.g.forColumn(e);let i=null,o=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(i=e),r.posList[e]==n&&(o=e);if(null===i&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===o&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<o)throw new Error(`End position ${o} exceeds positions length`);const a=s||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(i,o,a)}const Pn={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(fe.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Rn{constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??Pn;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(fe.DX.positionNames,this.data.positionNames),this.data.regions&&t.setTag(fe.DX.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await i.data.detectSemanticTypes(this.data.df),this.view=i.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${ds.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class On{constructor(e){this.call=e,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const t=e=>this.call.inputParams[e].property.description;this.inputs.table=o.tableInput("Table",this.call.inputParams.table.value??i.shell.tv.dataFrame,void 0,(()=>{}));const n=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE),s={filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE};this.inputs.sequence=o.columnInput("Sequence",i.shell.tv.dataFrame,n,this.sequenceInputChanged.bind(this),s),this.inputs.start=o.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=o.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=o.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=o.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const e in this.call.inputParams)o.tooltip.bind(this.inputs[e].captionLabel,t(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&ge.g.forColumn(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=ge.g.forColumn(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?ge.g.forColumn(e):null,n=this.inputs.start.input,s=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=s.options.length-1;e>=0;--e)s.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),s.options.add(r)}n.value=t?.posList[0]??"",s.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(fe.DX.regions):null,n=t?JSON.parse(t):null,s=this.inputs.region.input;for(let e=s.options.length-1;e>=0;--e)s.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),s.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),s.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let s=e.options.length-1;s>=0;--s){const r=e.options[s],i=JSON.parse(r.value);i&&t===i.start&&n===i.end&&(e.selectedIndex=s)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,s=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${s}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=o.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});o.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{ds.handleErrorUI(e)}))})).show()}widget(){const e=o.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=o.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{ds.handleErrorUI(e)}))}));return a.Widget.fromRoot(o.divV([e,o.div(t)]))}}var kn=n(8601);const Dn=OCL;class Fn{constructor(e){const t=e.split("|");t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],s=t.split(",");s[2].split("-").forEach(((e,t)=>{const r=s[t],i=e.split(":"),o={monomerIdx:parseInt(i[0])-1,rGroupId:parseInt(i[1].slice(1))};n.push({polymerId:r,bond:o})})),e.push(n)})),e}}class Gn{constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],s=[];return t.forEach((e=>{n.push(e),s.push("Backbone")})),{monomers:n,monomerTypes:s}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const s=t[n],r=t[n+1];e.push([{monomerIdx:s,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const s=n[t],r=s-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:s,rGroupId:1}])}return e}}class Bn{constructor(e){this.helmString=e;const t=this.helmString.split("$"),n=t[0].split("|");this.simplePolymers=n.map((e=>new Gn(e))),""!==t[1]&&(this.connectionList=new Fn(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,s=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(s)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const s=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===s))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const s=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,s),t.push(...s)})),this.connectionList&&this.connectionList.getConnectionData().forEach((n=>{const s=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,s.push(r)})),t.push(s)})),t}}class Vn{constructor(e){this.monomerSymbol=e}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,s=Math.atan(n);if(isNaN(s))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-s)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}class Un{constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupBondPositionMap=new Map,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const s=n[0];return this.bonds.replacePositionsInBondsByDummy([s]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),s}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s,nodeIdx:r}=n;this.bonds.bondedAtoms[s][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:s}=t;return this.bonds.bondedAtoms[n][(s+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const s=e[n-1];"H"===s?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,s)}))}}class Hn{constructor(){this.coordinates=[],this.rawAtomLines=[]}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,s=t.y+e.y;if(isNaN(n)||isNaN(s))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:s}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,s=t.y,r=n*Math.cos(e)-s*Math.sin(e),i=n*Math.sin(e)+s*Math.cos(e);if(isNaN(r)||isNaN(i))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:i}}))}}class jn extends Hn{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class Wn{constructor(){this.bondedAtomPairs=[],this.rawBondLines=[]}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,s)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:s,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:s}=e;this.bondedAtomPairs[n][s]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class Yn extends Wn{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Zn extends Vn{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new jn(n),this.bonds=new Yn(n),this.rGroups=new Un(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class qn extends Hn{constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,s)=>{const r=this.coordinates[s],i=r.x.toFixed(4)+"00",o=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,s,r,a)=>t+i+s+o+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class Kn extends Wn{constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,s,r,i,o)=>`${n}${t[0]}${r}${t[1]}${o}`))}))}}class zn extends Vn{constructor(e,t){super(t);const n=Lt.getInstance(e);this.atoms=new qn(n),this.bonds=new Kn(n),this.rGroups=new Un(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Xn{static getInstance(e,t){if(Lt.isMolfileV2K(e))return new Zn(e,t);if(Lt.isMolfileV3K(e))return new zn(e,t);throw new Error("Unsupported molfile version")}}class Jn{constructor(e,t,n,s,r,i){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=i,this.capGroupElements=[];const o=this.getLibraryMonomerObject();let a=o.molfile;Lt.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=Xn.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(o),n.bondedRGroupsMap.has(t)&&this.removeRGroups(n.bondedRGroupsMap.get(t)),this.capRemainingRGroups(),this.shiftCoordinates(s)}convertMolfileToV3KFormat(e,t,n){let s=null;try{if(s=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),s)return s.get_v3Kmolblock();throw new Error(`Cannot convert ${t} to molV3000`)}finally{s?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Qn{constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.monomerWrappers=[],this.helm=new Bn(e)}addMonomer(e,t,n){const s=new Jn(e,t,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(s)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),s=t.map((e=>this.monomerWrappers[e])),r=s[1].getAttachmentAtomByRGroupId(n[1]);s[0].replaceRGroupWithAttachmentAtom(n[0],r),s[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers(),this.monomerWrappers.forEach((n=>{e.push(...n.getAtomLines()),t.push(...n.getBondLines())}));const s=e.length,r=t.length;return[this.getV3KHeader(s,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n")}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const s=n+1;return e.replace(t,((e,t,n,r)=>t+s+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const s=n+1;return e.replace(t,((e,t,n,r)=>t+s+r))})),"M V30 END BOND"].join("\n")}}class es{constructor(e){this.molfileHandler=Lt.getInstance(e)}get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class ts{constructor(e,t){this.helmColumn=e,this.df=t,this.helmColumn=e}async convertToSmiles(){const e=await this.getSmilesList(),t=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(t,e.map((e=>null===e?"":e)))}async getSmilesList(){return(await this.convertToMolfileV3KColumn()).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}async getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),s=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){const t=Dn.Molecule.fromMolfile(n[e]).toMolfileV3();s[e]=t.replace("STERAC1","STEABS");const i=e/n.length*100;r.update(i,`${i?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,s)}async convertToRdKitBeautifiedMolfileColumn(e){const t=(await this.convertToMolfileV3KColumn()).toList(),n=await i.functions.call("Chem:getRdKitModule"),s=t.map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),r=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return e?await this.getMolV3000ViaOCL(s,r):a.Column.fromStrings(r,s.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}async convertToMolfileV3KColumn(){const e=await this.getPolymerGraphColumn(),t=await i.functions.call("Chem:getRdKitModule"),n=(await ms()).getBioLib(),s=e.toList().map(((e,s)=>{const r=this.helmColumn.get(s);if(!r)return"";let i="";try{i=this.getPolymerMolfile(r,e,t,n)}catch(e){const[t,n]=(0,Ce.yf)(e);ds.logger.error(t,void 0,n)}finally{return i}})),r=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",r,s)}async getPolymerGraphColumn(){return await i.functions.call("HELM:getMolfiles",{col:this.helmColumn})}getPolymerMolfile(e,t,n,s){const r=new es(t),i=new Qn(e,n,s);return r.monomerSymbols.forEach(((e,t)=>{const n=r.getMonomerShifts(t);i.addMonomer(e,t,n)})),i.compileToMolfile()}}async function ns(e,t,n){const s=new ts(t,e),r=await s.convertToRdKitBeautifiedMolfileColumn(n);return r.semType=a.SEMTYPE.MOLECULE,r}class ss{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class rs extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numerical;this.activitiesInput=o.columnInput("Activities",this.tableInput.value,a.Utils.firstOrNull(t),null,{filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=o.intInput("Similarity cutoff",80),this.methodsParams[N]=new ss}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){o.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=o.columnInput("Activities",this.tableInput.value,a.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return o.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}}function is(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function os(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}var as=n(706),ls=n(6286);class cs{constructor(e){this.separator=e,this.separatorSplitter=(0,Ee.Ar)(this.separator),this.splitter=this._splitter.bind(this)}_splitter(e){const t=this.separatorSplitter(e);return new us(t.originals,ge.lh[fe.r2.SEPARATOR])}}class us extends Ee.wx{get canonicals(){if(!this._canonicals){const e=this.length;this._canonicals=new Array(e);for(let t=0;t<e;++t)this._canonicals[t]=this.getCanonical(t)}return this._canonicals}getCanonical(e){if(this.isGap(e))return ls.G2;let t=this.seqCList[e];if(null===t){const n=this.getOriginal(e);t=n,")"===n[n.length-1]&&(t=this.seqCList[e]=n.replace(/\(\d+\)$/,""))}return t}constructor(e,t){super(e,t),this._canonicals=null,this.seqCList=new Array(this.length).fill(null)}}class hs extends a.Widget{constructor(e){super(o.div([],{}));const t=Object.assign({},...e.map((e=>({[e.name]:e}))));this.maxMonomerLengthProp=t.MaxMonomerLength,this.tooltipWebLogo=t.TooltipWebLogo,this.defaultSeparator=t.DefaultSeparator}async init(){const e=o.choiceInput("Monomer width mode",ds.properties.MonomerWidthMode,[ke.short,ke.long],(e=>{ds.properties.MonomerWidthMode=e})),t=o.intInput("Max monomer length",ds.properties.MaxMonomerLength,(e=>{ds.properties.MaxMonomerLength=e})),n=o.boolInput("Tooltip WebLogo",ds.properties.TooltipWebLogo,(e=>{ds.properties.TooltipWebLogo=e})),s=o.choiceInput("Default Separator",ds.properties.DefaultSeparator,[".","/","-"],(e=>{ds.properties.DefaultSeparator=e}));this.root.appendChild(o.form([e,t,n,s]))}}const ds=new Mn;async function ms(){return await Ht.getInstance()}let ps=null;class fs{constructor(e){this._palette=e}get(e){return this._palette[e]}}let gs=null;async function ys(){const e="Bio: _package.initBio()";ds.logger.debug(`${e}, start`);const t=await i.functions.call("Chem:getRdKitModule"),n=window.performance.now();await Promise.all([(async()=>{const e=await Ht.getInstance();await e.loadLibraries(),gs=e.getBioLib()})(),(async()=>{const e=await ds.getProperties(),t=new _n(e);ds.properties=t})()]).finally((()=>{ds.completeInit();const t=window.performance.now();ds.logger.debug(`${e}, loading ET: ${t-n} ms`)}));const s=[],r=[],o=gs.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(o).forEach((e=>{s.push(e);const n=o[e].replaceAll("#R","O "),i=t.get_mol(n),a=JSON.parse(i.get_descriptors()).CrippenClogP;r.push(a),i?.delete()}));const a=r.reduce(((e,t)=>e+t),0)/r.length||0,l={};for(let e=0;e<s.length;e++)l[s[e]]=r[e]<a?"#4682B4":"#DC143C";ps=new fs(l),ds.logger.debug(`${e}, end`)}function bs(e){const t=new Nn(e);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();i.shell.error(t)})),t}function vs(){return gs}function ws(){return gs}function Cs(e){return ge.g.forColumn(e)}function As(e){const t="getRegionTopMenu",n=a.Func.find({package:ds.name,name:t});if(1!==n.length)throw new Error(`Package '${ds.name}' func '${t}' not found`);const s=n[0].prepare({table:e.dataFrame,sequence:e});return new On(s).widget()}async function Ss(e){return async function(){const e=o.label("Manage monomer libraries");return Wt()(e).addClass("d4-link-action"),e.onclick=async()=>await qt(),new a.Widget(e)}()}function xs(e){try{new On(e).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;i.shell.error(`Get region editor error: ${t}`),ds.logger.error(t,void 0,n)}}function Es(e){const t=new Cn;o.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function Ts(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE});o.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()})).show()}function Is(e){const t=new rs({semtype:a.SEMTYPE.MACROMOLECULE});o.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()})).show()}function _s(e){const t=new hs(e);return t.init().then(),t}function Ms(){return new je}function $s(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);const n=o.input.choice("Monomer width",{value:null!=e?.temp["monomer-width-mode"]?e.temp["monomer-width-mode"]:ds.properties?.MonomerWidthMode??ke.short,items:[ke.short,ke.long],onValueChanged:()=>{const t=n.value;e.temp["monomer-width-mode"]=t,e.setTag(".mm.cellRenderer.settingsChanged",Fe.true),e.dataFrame.fireValuesChanged(),r.enabled=n.value===ke.short}});n.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const s=parseInt(e.getTag(Me.maxMonomerLength)),r=o.input.slider("Max monomer length",{value:isNaN(s)?ds.properties?.MaxMonomerLength??4:s,min:1,max:16,step:1,onValueChanged:()=>{const t=r.value;i.innerText=r.stringValue,e.setTag(Me.maxMonomerLength,t.toString()),e.setTag(".mm.cellRenderer.settingsChanged",Fe.true),e.dataFrame.fireValuesChanged()}}),i=o.divText(r.stringValue,"ui-input-description");r.addOptions(i),r.setTooltip(`The max length of monomer name displayed without shortening in '${ke.short}' monomer width mode.`),r.enabled=n.value===ke.short;const l=o.intInput("Monomer margin",e.temp[".mm.cellRenderer.gapLength"]??0,(t=>{e.temp[".mm.cellRenderer.gapLength"]=t,e.setTag(".mm.cellRenderer.settingsChanged",Fe.true),e.dataFrame.fireValuesChanged()}));l.setTooltip("The size of margin between monomers (in pixels)");const c=o.boolInput("Color code",null==e?.temp["color-code"]||e.temp["color-code"],(t=>{e.temp["color-code"]=t,e.dataFrame.fireValuesChanged()}));c.setTooltip("Color code");const u=o.stringInput("Reference sequence",null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",(t=>{e.temp["reference-sequence"]=t,e.dataFrame.fireValuesChanged()}));u.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const h=o.boolInput("Compare with current",null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],(t=>{e.temp["compare-with-current"]=t,e.dataFrame.fireValuesChanged()}));h.setTooltip('When on, all sequences get rendered in the "diff" mode');const d=o.inputs([n,r,l,u,c,h]);return new a.Widget(d)}(e)}function Ns(e){return(0,$n.t)(e)}function Ls(){return new je}function Ps(){return new We}function Rs(e,t,n,s,r){const i=new it.k(s,r,n,t);return"Local alignment"==e?i.smithWaterman():i.needlemanWunch()}function Os(){return new Qe.OZ}function ks(){return new rt}function Ds(e,t,n,s){return Ln(e,t??null,n??null,s??null)}async function Fs(e,t,n,s,r){const o=Ln(t,n??null,s??null,r??null);t.dataFrame.columns.add(o),await i.data.detectSemanticTypes(t.dataFrame)}async function Gs(e,t,n,s,r,u,h,d){if(!(0,yn.n)(t,"Activity Cliffs"))return;const m=is(e),p={units:t.getTag(a.TAGS.UNITS),aligned:t.getTag(fe.DX.aligned),separator:t.getTag(fe.DX.separator),alphabet:t.getTag(fe.DX.alphabet)},f=u,g=t,y=async()=>await me(e,g,m,"Activity cliffs",n,s,f,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,p,h,ut,ht,ft),b=r===c.A.UMAP?2e5:2e4,v=r===c.A.UMAP?5e3:2e3;if(e.rowCount>b)return void i.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${b}`);const w=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>v&&!d?.[l.sS]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{y().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():y().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,Ce.yf)(e);throw ds.logger.error(t,void 0,n),e})).finally((()=>{w.close()}))}async function Bs(e,t,n=1,s=.6,r="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:i,options:o}=await at(e,t,r);return{entries:i,options:{...o,gapOpen:n,gapExtend:s}}}async function Vs(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,ct.HV)(e,!1);const n=e.temp["monomeric-mols"],s=await i.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(s.length).fill(null);for(let e=0;e<s.length;e++){if(s.isNone(e)||!s.get(e))continue;const t=s.get(e);r[e]=H.Z.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}async function Us(e,t,s,r,c,u,h,d){if((0,yn.n)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??(h={}),await async function(e,t,s,r,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},f={},g=null,y={}){const b={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?i.shell.tableView(e.name)??i.shell.addTableView(e):null,w=async()=>{const w=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let C;try{const A=is(e);function S(n,r,i){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!C&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??os(t,s)}))),f[l.Ec]&&(C?.root&&o.setUpdateIndicator(C.root,!1),c.init((e=>i[0]?i[0][e]:void 0)),u.init((e=>i[1]?i[1][e]:void 0)));const h=n/r*100;w.update(h,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function x(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??os(t,s)}),o.setUpdateIndicator(C.root,!0));const m=i.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&C?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===C?.getOptions()?.look?.title&&(i.events.fireCustomEvent(W,{}),m.unsubscribe(),n?.(),w.close())})),g=new Promise((async(e,i)=>{try{n=e;const i=[];for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const s=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:l}=await n.apply({[s]:t[e],[o]:r[e],...p.preprocessingFuncArgs[e]??{}});i.push({entries:a,options:l}),p.distanceFnArgs.push(l)}else{const n=t[e].toList(),s={};i.push({entries:n,options:s}),p.distanceFnArgs.push(s)}}e(await K(i.map((e=>e.entries)),s,r,c,h,p,f[l.sS]?void 0:S))}catch(e){i(e)}})),y=await g;return w.close(),m.unsubscribe(),y}const E=await x();if(m&&E){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const I=await function(e,t,s,r){return hn(this,void 0,void 0,(function*(){return new Promise((function(i,o){const a=new Worker(new URL(n.p+n.u(796),n.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:s}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):i(t)}}))}))}(E[0],E[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),_=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(_).init((e=>I[e].toString())),C&&(C.props.colorColumnName=_)}catch(M){i.shell.error("Clustering embeddings failed"),console.error(M)}finally{T.close()}}if(E){const $=e.columns.byName(A[0]),N=e.columns.byName(A[1]);if($.init((e=>E[0][e])),N.init((e=>E[1][e])),g)try{const L=g.inputs[0].name,P=g.inputs[1].name;await g.prepare({[L]:$,[P]:N,...y}).call(!0)}catch(R){i.shell.error("Post-processing failed"),console.error(R)}if(C)return o.setUpdateIndicator(C.root,!1),C.helpUrl="/help/compute/sequence-space",C}}catch(O){i.shell.error("Dimensionality reduction failed"),console.error(O),w.close(),C&&o.setUpdateIndicator(C.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[l.sS])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await w();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await w();t(e)}}catch(e){n(e)}}))}(e,[t],s,[r],[1],[u],"MANHATTAN",c,d??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[l.sS]})}async function Hs(e,t,n){const s=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const s=(await ms()).getBioLib();await async function(e,t,n,s){if(0===a.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(n){const n=ge.g.forColumn(t);return n.isHelm()||(t=n.convert(fe.r2.HELM)),async function(e,t){const n=await ns(e,t);e.columns.add(n,!0),await i.data.detectSemanticTypes(e)}(e,t)}if(!(0,yn.n)(t,"To Atomic Level"))return;const r=await(0,kn.i0)(e,t,s);null!==r.col&&(e.columns.add(r.col,!0),await i.data.detectSemanticTypes(e)),r.warnings&&r.warnings.length>0&&i.shell.warning(o.list(r.warnings))}(e,t,n,s)}finally{s.close()}}function js(){(0,vn.K)().catch((e=>{const[t,n]=(0,Ce.yf)(e);if(e instanceof bn.rE)return i.shell.warning(e.element),void ds.logger.warning(t);i.shell.error(t),ds.logger.error(t,void 0,n)}))}async function Ws(e=null,t=null){return(0,vn.K)({col:e,clustersCol:t})}async function Ys(){const e=i.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(ge.g.forColumn(e),!0))),n=async t=>{if(!(0,yn.n)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});i.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let s=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),s=t.find((e=>ge.g.forColumn(e).isMsa())),r=o.choiceInput("Column",s?s.name:e[0],e);o.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(o.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else s=t[0];s&&await n(s)}else i.shell.error("Current table does not contain sequences")}function Zs(e){return new ye.i(e).importFasta()}function qs(e){return console.log(e),[]}function Ks(){const e=(0,Ae.B)()[0];(0,xt.O)(e)}function zs(){return new In}async function Xs(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await i.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let s=0;const r=[];for(const o of n)try{const t=await i.dapi.files.readAsText(e+o.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await i.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:o.path,result:"detected",column:e.name,message:`units: ${e.getTag(a.TAGS.UNITS)}`})}catch(e){r.push({file:o.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{s+=1,t.update(100*s/n.length,`Test ${o.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const o=a.DataFrame.fromObjects(r);return o.name=`datasets_detectMacromolecule_${e}`,o}async function Js(e,t){await(0,An.n)(e,t)}function Qs(e){const t=ge.g.forColumn(e).stats;return Object.keys(t.freq)}function er(){return new wt}function tr(){const e=i.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function nr(){return new At}function sr(){const e=i.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function rr(e){const t=(0,Ae.B)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new ct.uH(t)}function ir(e){i.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),i.shell.tv.grid.scrollToCell(e,0)}async function or(e,t,n){return we(e,t,n,pe.IDENTITY)}async function ar(e,t,n){return we(e,t,n,pe.SIMILARITY)}async function lr(){qt()}function cr(){(0,Et.C2)()}function ur(){return new Tt.ST}async function hr(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new wn(e,"webLogoLargeApp"),n=await ds.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function dr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new wn(e,"webLogoAggApp"),n=await ds.files.readCsv("samples/FASTA_PT_activity.csv");await i.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function mr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Rn(e,"getRegionApp");await t.init()}finally{e.close()}}async function pr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await ds.files.readCsv("samples/HELM_empty_vals.csv"),n=new Rn(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function fr(){const e=a.DataFrame.fromColumns((0,as.io)());i.shell.addTableView(e)}function gr(){const e=a.DataFrame.fromColumns([(0,as.wl)(fe.r2.FASTA)]);i.shell.addTableView(e)}function yr(){const e=a.DataFrame.fromColumns([(0,as.wl)(fe.r2.HELM)]);i.shell.addTableView(e)}function br(e,t){!function(e,t){const n=ge.g.forColumn(e.column),s=Object.values(fe.r2).filter((e=>e!==n.units));t.group("Copy").items(s,(t=>{const n=e.column,s=e.rowIndex,r=ge.g.forColumn(n),o=t===fe.r2.SEPARATOR?ds.properties.DefaultSeparator:void 0,a=r.getJoiner({notation:t,separator:o})(r.getSplitted(s));navigator.clipboard?(navigator.clipboard.writeText(a),i.shell.info(`Value of notation '${t}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t)}async function vr(){await async function(){let e,t;try{const n=new en("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await n.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,t=await ds.files.readCsv(nn),e=i.shell.addTableView(t),e.grid.columns.byName("cluster").visible=!1,e.grid.columns.byName("sequence_id").visible=!1,e.grid.columns.byName("sequence").width=300,e.grid.columns.byName("activity").visible=!1,e.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const n=await t.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await t.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});e.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{t.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{t.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(e){tn(e)}}()}async function wr(){await async function(){let e,t,n,s,r;try{const o=new en("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await o.step("Load DNA sequences",(async()=>{[s,e,t]=await Promise.all([ds.files.readCsv(dn),sn(),rn()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(e,t,n,s){let r;{const e=Object.values(Jt);for(let n=0;n<e.length;n++){const s=e[n];if(!t.col(s)){const r=n==e.length-1;t.columns.add(a.Column.float(s,t.rowCount),r)}}if(t.rowCount>=1){const s=t.getCol(n).toList(),r=Date.now();ds.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const i=await K([s],"UMAP",[lt.W.Levenshtein],[1],"MANHATTAN",{distanceFnArgs:[{}]}),o=Date.now();ds.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-r)/1e3} s`);for(let n=0;n<e.length;n++){const s=e[n],r=t.getCol(s),o=i[n];r.init((e=>o[e]))}const a=Date.now();ds.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}r=await t.plot.fromType(a.VIEWER.SCATTER_PLOT,{xColumnName:Jt.X,yColumnName:Jt.Y,lassoTool:!0})}return e.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),r}(n,s,mn),r.setOptions({color:"activity"})}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const r=await e.calcDistanceMatrix(s,[mn]),i=await an(r.data,s.rowCount,1),o=e.parseClusterMatrix(i);t.injectTreeForGrid(n.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{s.selection.set(65,!0)}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{[67,72,77,82,83,84,85,91,93].forEach((e=>s.selection.set(e,!0))),s.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(e){tn(e)}}()}async function Cr(){await async function(){let e,t,n,s,r;const o=c.A.UMAP;try{const l=new en("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[n,e,t]=await Promise.all([ds.files.readCsv(pn),sn(),rn()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=300,s.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{const e=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];r=await Gs(n,n.getCol("Sequence"),n.getCol("Activity"),80,o,ot.U.LEVENSHTEIN,e,{}),s.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),Wt()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const r=a.TaskBarProgressIndicator.create("Running sequence clustering..."),i=await e.calcDistanceMatrix(n,["sequence"]),o=await an(i.data,n.rowCount,1),l=e.parseClusterMatrix(o);r.close(),t.injectTreeForGrid(s.grid,l,void 0,150,void 0),s.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const e=r.dataFrame.temp[".cliffsDfGrid"];e.dataFrame.rowCount>0&&(e.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(e){tn(e)}}()}async function Ar(){await async function(){const e="HELM";let t,n,s;try{await new en("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,t=await ds.files.readCsv("samples/HELM.csv"),n=i.shell.addTableView(t);for(let t=0;t<n.grid.columns.length;t++){const s=n.grid.columns.byIndex(t);[e,"Activity"].includes(s.name)||(s.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=t.getCol(e);await Hs(t,n,!1)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${e})`;t.currentCell=t.cell(1,n);const r=t.currentCell.value,i=new a.chem.Sketcher(a.chem.SKETCHER_MODE.INPLACE);i.setMolFile(r),s=o.dialog().add(i).show(),await(0,Ke.gw)(3e3),s.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(e){tn(e)}}()}async function Sr(){await async function(){let e,t,n,s,r,o;const l="msa(HELM)",h=c.A.UMAP,d=(await fn.lp.getDockerContainer()).id,m=fn.lp.getDockerContainer();let p,f;try{const c=new en("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{[p,t]=await Promise.all([(async()=>(await m).status)(),ds.files.readCsv(gn)]),e=i.shell.addTableView(t),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,"started"===p||"checking"===p?(ds.logger.debug(`demoBio05UI(), PepSeA ('${fn.lp.dcName}') docker container status = '${p}'.`),f=Promise.resolve()):(ds.logger.warning(`demoBio05UI(), PepSeA ('${fn.lp.dcName}') docker container is trying to start...`),await i.dapi.docker.dockerContainers.run(d),f=async function(e,t,n=3e4,s){const r=window.performance.now(),o=new u.Subject,a=async()=>{const n=await i.dapi.docker.dockerContainers.find(e);return n.status===t&&o.next(n),n};let l;try{await(0,Ke.zg)(o,(e=>{const n=window.performance.now();s.debug(`awaitStatus(), docker container ('${e.name}') GET status = '${t}' in ${n-r} ms.`)}),(async()=>{const e=await a();s.debug(`awaitStatus(), docker container ('${e.name}') HAS status = '${e.status}'.`),l=window.setInterval(a,200)}),n)}finally{window.clearInterval(l)}}(d,"started",3e4,ds.logger))}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{const e=a.TaskBarProgressIndicator.create("MSA by PepSeA ...");try{await f,n=t.getCol("HELM");const e=fn.Jy[0],r=1.53,o=0;if(s=await(0,fn.f3)(n,l,e,r,o,void 0),!s)throw new Error("Empty MSA result.");t.columns.add(s),await i.data.detectSemanticTypes(t)}finally{e.close()}}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{const n=a.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];o=await Us(t,s,h,ot.U.LEVENSHTEIN,!0,n),e.dockManager.dock(o,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await t.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(e){tn(e)}}()}async function xr(e){const t=(0,be.Xk)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}async function Er(e,t,n){const s=await e.readAsString();await async function(e,t,n){const s=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const o=await i.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await i.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${o.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,s.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,Ke.gw)(0))}l>0?i.shell.warning(`detectMacromolecule failed ${l} / ${n}`):i.shell.info(`detectMacromolecule success ${n}`)}finally{s.close()}}(s,t,n)}async function Tr(e,t,n){return ns(e,t,n)}function Ir(e,t){e.temp[ge.dm.notationProvider]=new cs(t)}},9017:(e,t,n)=>{"use strict";n.d(t,{k:()=>i});class s{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class i{fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",s="",i="";const o=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)i+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=i+n,s=this.seq2.substr((t-1)*this.step,this.step)+s):this.dpGrid[e][t].parentJ==t?(s=i+s,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:i+n,s=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+s:i+s);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,s,o)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new s);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new s);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let s=1;s<=this.len1;s++)for(let r=1;r<=this.len2;r++)this.fillOne(s,r),this.dpGrid[s][r].value<=0?(this.dpGrid[s][r].value=0,this.dpGrid[s][r].parentI=0,this.dpGrid[s][r].parentJ=0):0==this.dpGrid[this.dpGrid[s][r].parentI][this.dpGrid[s][r].parentJ].value&&(this.dpGrid[s][r].parentI=0,this.dpGrid[s][r].parentJ=0),this.dpGrid[s][r].value>e&&(e=this.dpGrid[s][r].value,t=s,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,s=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],this.BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]],this.NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]],this.PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]],this.PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]],this.PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]],this.TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]],this.CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23},this.CONNUCL={A:0,T:1,C:2,G:3},this.CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63},this.setMethod(s),this.setSequences(e,t),this.setGap(n)}}},7983:(e,t,n)=>{"use strict";n.d(t,{HV:()=>p,QF:()=>m,pf:()=>d,uH:()=>h});var s=n(4469),r=n(3870),i=n(976),o=n(7241),a=n(4293),l=n(2997),c=n(8447);const u="substr_helm";class h{constructor(e){this.col=e[0],this.createUI()}editHelmLinkAction(){(0,a.Y)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(u,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===c.r2.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===c.r2.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,a.Y)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.getTag(i.TAGS.UNITS),this.separator=this.col.getTag(c.DX.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=s.shell.tv.dataFrame,t={filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE};this.columnsInput=r.columnInput("Column",e,this.col,(e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()}),t),this.substructureInput=r.stringInput("Substructure",""),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const n=i.DataFrame.create(1);n.columns.addNewString(u).init((e=>"")),n.col(u).semType=this.col.semType,n.col(u).setTag(i.TAGS.UNITS,c.r2.HELM),this.grid=n.plot.grid(),this.separatorInput=r.stringInput("Separator",this.separator),this.inputsDiv=r.div(),this.units=this.col.getTag(i.TAGS.UNITS),this.separator=this.col.getTag(c.DX.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,t=this.units===c.r2.HELM?n.get(u,0):this.substructureInput.value;this.units===c.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(t=t.replaceAll(this.separatorInput.value,this.separator)),e=this.units===c.r2.HELM?await m(t,this.col):d(t,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const s=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),s=e.charAt(0)===t,r=e.charAt(e.length-1)===t,i=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return s?r?`${n}${i}${n}`:`${n}${i}${n}|${n}${i}$`:r?`^${i}${n}|${n}${i}${n}`:`^${i}${n}|${n}${i}${n}|${n}${i}$`}(e,n):e,r=i.BitSet.create(t.length);for(let n=0;n<t.length;n++){const i=t.get(n);(i.match(s)||i===e)&&r.set(n,!0,!1)}return r}async function m(e,t){t.version!==t.temp["last-invalidated-version"]&&await p(t,!0);const n=i.Column.string("helm",1).init((t=>e));n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,c.r2.HELM);const r=await(0,o.D)(n,!0,t.temp["monomers-dict"]);return(await s.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:r.get(0),molBlockFailover:""})).get(0)}async function p(e,t){const n=i.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,l.gw)(10);const n=new Map,s=await(0,o.D)(e,t,n);e.temp["monomeric-mols"]=s,e.temp["monomers-dict"]=n,e.temp["last-invalidated-version"]=e.version}finally{n.close()}}},2568:(e,t,n)=>{"use strict";n.d(t,{n:()=>o});var s=n(4469),r=n(976),i=n(8607);function o(e,t,n=[],o=[],a=!0){const[l,c]=function(e,t,n=[],o=[]){let a=!0,l="";const c=i.g.forColumn(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)s.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(e,t,n,o);return a&&!l&&s.shell.warning(c),l}},3553:(e,t,n)=>{"use strict";n.d(t,{Of:()=>i,WY:()=>c,jB:()=>u,rs:()=>a});var s,r,i,o,a,l=n(8341);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(s||(s={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(i||(i={})),function(e){e.CELL_CHANGING="isCellChanging"}(o||(o={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:l.Jy[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(e,t,n)=>{"use strict";n.d(t,{O:()=>d});var s=n(976),r=n(3870),i=n(4469),o=n(3336),a=n.n(o),l=n(8447),c=n(8607);let u=null,h=[];function d(e){let t=e??i.shell.t.columns.bySemType("Macromolecule");if(!t)throw new Error("No column with Macromolecule semantic type found");let n=c.g.forColumn(t),o=n.notation;const d=r.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),m=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=r.columnInput("Column",i.shell.t,t,(e=>{e.semType===s.SEMTYPE.MACROMOLECULE?(t=e,n=c.g.forColumn(t),o=n.notation,o===l.r2.HELM&&(y.value="/"),d.textContent="Current notation: "+o,g=m.filter((e=>e!==o)),v=r.choiceInput("Convert to",g[0],g,b),b(),u?.clear(),u?.add(r.div([d,p.root,v.root,y.root]))):p.value=t})),f=["-",".","/"];let g=m.filter((e=>e!==o));const y=r.choiceInput("Separator",f[0],f),b=()=>{v.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.choiceInput("Convert to",g[0],g,b);b(),v.onChanged((()=>{b()})),null==u&&(u=r.dialog("Convert Sequence Notation").add(r.div([d,p.root,v.root,y.root])).onOK((async()=>{const e=v.value,n=e===l.r2.SEPARATOR?y.value:void 0;await async function(e,t,n){const s=c.g.forColumn(e).convert(t,n);e.dataFrame.columns.add(s);const r=await i.functions.call("Bio:detectMacromolecule",{col:s});return r&&(s.semType=r),await i.data.detectSemanticTypes(e.dataFrame),s}(t,e,n)})).show({x:350,y:100}),h.push(u.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],u=null}))))}},6032:(e,t,n)=>{"use strict";n.d(t,{Ns:()=>o});var s=n(4469),r=n(2997),i=n(8341);async function o(e=6e4){const t=await i.lp.getDockerContainer();await async function(e,t=6e4){let n=e,i=!1;for(let o=0;o<t/200;++o){if(null===n&&(n=await s.dapi.docker.dockerContainers.find(e.id)),a(n)){i=!0;break}switch(n.status){case"stopped":await s.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,r.gw)(200)}if(!i)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},525:(e,t,n)=>{"use strict";n.d(t,{K:()=>M});var s=n(4469),r=n(976),i=n(3870),o=n(2997),a=n(8447),l=n(8607),c=n(6098),u=n(8341),h=n(2568),d=n(3553),m=n(6032),p=n(9644),f=n(3379),g=n.n(f),y=n(7795),b=n.n(y),v=n(569),w=n.n(v),C=n(3565),A=n.n(C),S=n(9216),x=n.n(S),E=n(4589),T=n.n(E),I=n(9564),_={};async function M(e={}){return new Promise((async(t,n)=>{var a,l,h;e.clustersCol??(e.clustersCol=null),e.pepsea??(e.pepsea={}),(a=e.pepsea).method??(a.method=d.jB.pepsea.method),(l=e.pepsea).gapOpen??(l.gapOpen=d.jB.pepsea.gapOpen),(h=e.pepsea).gapExtend??(h.gapExtend=d.jB.pepsea.gapExtend);const m=e.col?.dataFrame??s.shell.t,p=e.col??m.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==p){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return s.shell.warning(e),void n(new c.rE(i.divText(e)))}const f=i.choiceInput("Method",e.pepsea.method,u.Jy);f.setTooltip("Alignment method");const g=i.floatInput("Terminal gap",e?.kalign?.terminalGap??null);g.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const y=i.p(`Kalign version: ${d.WY}`,"kalign-version"),b=i.floatInput("Gap open",e.pepsea.gapOpen);b.setTooltip("Gap opening penalty at group-to-group alignment");const v=i.floatInput("Gap extend",e.pepsea.gapExtend);v.setTooltip("Gap extension penalty to skip the alignment");const w=i.inputs([b,v,g]),C=i.button("Alignment parameters",(()=>{w.hidden=!w.hidden,[b,v,g].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");C.classList.add("msa-params-button"),w.hidden=!0,C.prepend(i.icons.settings((()=>null)));const A=[f.root.style],S=[g.root.style,y.style];let x,E=p;const T=i.columnInput("Sequence",m,p,(async e=>{if(!e||e.semType!==r.SEMTYPE.MACROMOLECULE)return M.disabled=!0,await(0,o.gw)(0),void(T.value=E);E=e,M.disabled=!1,x=await N(T.value,m,A,S,f,I,b,v,g)}),{filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE});T.setTooltip("Sequences column to use for alignment");const I=i.columnInput("Clusters",m,e.clustersCol);I.nullable=!0;const _=i.dialog("MSA").add(T).add(I).add(f).add(w).add(C).add(y).onOK((async()=>{await $(T,m,x,t,n)})),M=_.getButton("OK");if(T.fireChanged(),e.col)return x=await N(e.col,m,A,S,f,I,b,v,g),void await $(T,m,x,t,n);_.show()}))}async function $(e,t,n,i,o){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return o("PepSeA container has not started");t.columns.add(a),await s.data.detectSemanticTypes(t),i(a)}catch(e){o(e)}finally{l.close()}}async function N(e,t,n,i,o,f,g,y,b){try{if(e.semType!==r.SEMTYPE.MACROMOLECULE)return;const s=t.columns.getUnusedName(`msa(${e.name})`);if((0,h.n)(e,e.name,[a.r2.FASTA,a.r2.SEPARATOR],[a.fb.DNA,a.fb.RNA,a.fb.PT],!1)){L(n,i,"kalign"),g.value=null,y.value=null,b.value=null;const t=l.g.forColumn(e),r=t.isFasta()?e:t.convert(a.r2.FASTA);return async()=>await(0,c.U4)(r,!1,s,f.value)}if((0,h.n)(e,e.name,[a.r2.HELM],[],!1))return L(n,i,"pepsea"),g.value??(g.value=d.jB.pepsea.gapOpen),y.value??(y.value=d.jB.pepsea.gapExtend),async()=>(await(0,m.Ns)(),(0,u.f3)(e,s,o.value,g.value,y.value,f.value));if((0,h.n)(e,e.name,[a.r2.SEPARATOR],[a.fb.UN],!1)){const t=l.g.forColumn(e).convert(a.r2.HELM);return L(n,i,"pepsea"),g.value??(g.value=d.jB.pepsea.gapOpen),y.value??(y.value=d.jB.pepsea.gapExtend),async()=>(await(0,m.Ns)(),(0,u.f3)(t,s,o.value,g.value,y.value,f.value))}return g.value=null,y.value=null,b.value=null,void L(n,i,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();s.shell.error(t),p._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}_.styleTagTransform=T(),_.setAttributes=A(),_.insert=w().bind(null,"head"),_.domAPI=b(),_.insertStyleElement=x(),g()(I.Z,_),I.Z&&I.Z.locals&&I.Z.locals},6098:(e,t,n)=>{"use strict";n.d(t,{rE:()=>D,Xd:()=>V,U4:()=>G});var s=n(3870),r=n(976),i=n(6414),o=n.n(i),a=n(5226),l=n(8447);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),m=e=>"object"==typeof e&&null!==e||"function"==typeof e,p=new Map([["proxy",{canHandle:e=>m(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>m(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(s){if(!s||!s.data)return;const{id:r,type:i,path:o}=Object.assign({path:[]},s.data),a=(s.data.argumentList||[]).map(x);let l;try{const t=o.slice(0,-1).reduce(((e,t)=>e[t]),e),n=o.reduce(((e,t)=>e[t]),e);switch(i){case"GET":l=n;break;case"SET":t[o.slice(-1)[0]]=x(s.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch((e=>({value:e,[d]:0}))).then((e=>{const[s,o]=S(e);t.postMessage(Object.assign(Object.assign({},s),{id:r}),o),"RELEASE"===i&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let s=!1;const r=new Proxy(n,{get(n,i){if(b(s),i===h)return()=>E(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),s=!0}));if("then"===i){if(0===t.length)return{then:()=>r};const n=E(e,{type:"GET",path:t.map((e=>e.toString()))}).then(x);return n.then.bind(n)}return v(e,[...t,i])},set(n,r,i){b(s);const[o,a]=S(i);return E(e,{type:"SET",path:[...t,r].map((e=>e.toString())),value:o},a).then(x)},apply(n,r,i){b(s);const o=t[t.length-1];if(o===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===o)return v(e,t.slice(0,-1));const[a,l]=C(i);return E(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},l).then(x)},construct(n,r){b(s);const[i,o]=C(r);return E(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:i},o).then(x)}});return r}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map((e=>e[0])),w(t.map((e=>e[1])))]}const A=new WeakMap;function S(e){for(const[t,n]of p)if(n.canHandle(e)){const[s,r]=n.serialize(e);return[{type:"HANDLER",name:t,value:s},r]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return p.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise((s=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==r||(e.removeEventListener("message",t),s(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:r},t),n)}))}const T="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),u=(s.data.argumentList||[]).map(m);let l;try{const c=n.slice(0,-1).reduce((d,h)=>d[h],e),f=n.reduce((d,h)=>d[h],e);switch(a){case"GET":l=f;break;case"SET":c[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(c,u);break;case"CONSTRUCT":{const d=new f(...u);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:h}=new MessageChannel;w(e,h),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(c){l={value:c,[y]:0}}Promise.resolve(l).catch(c=>({value:c,[y]:0})).then(c=>{const[f,d]=S(c);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),F(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function F(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function p(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(p(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(u=>u.toString())}).then(()=>{F(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const u=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return u.then.bind(u)}return b(e,[...r,n])},set(a,n,u){p(s);const[l,c]=S(u);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},c).then(m)},apply(a,n,u){p(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[c,f]=M(u);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:c},f).then(m)},construct(a,n){p(s);const[u,l]=M(n);return g(e,{type:"CONSTRUCT",path:r.map(c=>c.toString()),argumentList:u},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function M(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),x="eager",k="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const u=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${u}`),t.fs.symlink(u,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var u;let n=i;return((u=a==null?void 0:a.features)==null?void 0:u.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==k&&(s.loading=x,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};if(t.config.printInterleaved&&(o=s.stdout),s.reinit===!0){const a=t.base.module.FS.cwd();Object.assign(s,s.config),s.ready=!1,await this.init(),s.isBaseModule&&this.mount(),this.cd(a)}return o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=x),e.loading===k){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>e.stdout+=`${i}
`,printErr:t.config.printInterleaved?i=>e.stdout+=`${i}
`:i=>e.stderr+=`${i}
`});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",I=typeof window<"u"&&window.Blob&&new Blob([atob(T)],{type:"text/javascript;charset=utf-8"});function _(){const e=I&&(window.URL||window.webkitURL).createObjectURL(I);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+T)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const M={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,callback:null,debug:!1,env:"prd"};class ${constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},M,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new _;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var N=n(850);class L{static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,N.hu)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}L.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class P{constructor(e="categorial"){this.aa2num=L.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const s=["NH2","COOH"];if(e.startsWith(s[0])){const n=s[0].length;(0,N.hu)("-"==e[n],`Wrong sequence format: ${s[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(s[1])){const t=s[1].length+1;(0,N.hu)("-"==e[n-t],`Wrong sequence format: ${s[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return P._dropDefises(P._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let s=0;s<t;++s){const t=e[s];(0,N.hu)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[s]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const s=e[n];(0,N.hu)(s in this.num2aa,`Unknown code '${s}' found in vector '${e}'`),t+=this.num2aa[s]}return t}}var R=n(3553);const O="input.fa",k="result.fasta";class D extends Error{constructor(e,t){super(e.innerText,t),this.element=e}}function F(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function G(e,t=!1,n="",s=null,i,o,c){let u=e.toList();t&&(u=u.map((e=>P.clean(e).replace(/\-/g,""))));const h=e.length;s??(s=r.Column.string("Clusters",h).init("0")),s.type!=r.COLUMN_TYPE.STRING&&(s=s.convertTo(r.TYPE.STRING)),s.compact();const d=s.categories,m=s.getRawData(),p=new Array(d.length),f=new Array(d.length);for(let e=0;e<h;++e){const t=m[e];(p[t]??(p[t]=[])).push(u[e]),(f[t]??(f[t]=[])).push(e)}V(f,d);const g=await new $(["base/1.0.0",{tool:"kalign",version:R.WY,reinit:!0}]),y=r.Column.string(n,h);for(let e=0;e<d.length;++e){const t=F(p[e]);await g.fs.writeFile(O,t);const n=`${void 0!==i?` --gpo ${i}`:""}${void 0!==o?` --gpe ${o}`:""}${void 0!==c?` --tgpe ${c}`:""}`,s=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(s);const r=await g.cat(k);if(!r){const e=B(s,1);throw new Error(e)}const l=new a.i(r).sequencesArray,u=f[e];for(let e=0;e<l.length;++e)y.set(u[e],l[e])}const b=e.getTag(r.TAGS.UNITS),v=e.getTag(l.DX.alphabet);return y.setTag(r.TAGS.UNITS,b),y.setTag(l.DX.aligned,"SEQ.MSA"),y.setTag(l.DX.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(e,t){const n=[],s=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=s.exec(e))&&(void 0===t||n.length<t);)n.push(r[1]);return n.join("\n")}function V(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=s.div([s.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...o()(n).take(3).map((e=>{let r=t[e];return r.length>25&&(r=r.slice(0,25)+"..."),s.divText(`"${r}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[s.divText("...")]:[]]);throw new D(e)}}},8341:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>u,f3:()=>d,lp:()=>c});var s=n(4469),r=n(976),i=n(8447),o=n(6098),a=n(3553),l=n(9644);const c=new class{constructor(){this.dcName="bio"}async getDockerContainer(){return await s.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n="ginsi",s=1.53,l=0,u=null,d){const p=await c.getDockerContainer();if("started"!==p.status&&"checking"!==p.status)throw new Error("PepSeA container has not started yet");const f=e.length;u??(u=r.Column.int("Clusters",f).init(0)),u.type!=r.COLUMN_TYPE.STRING&&(u=u.convertTo(r.TYPE.STRING));const g=u.categories,y=u.getRawData(),b=new Array(g.length),v=new Array(g.length);for(let t=0;t<f;++t){const n=y[t],s=g[n];if(""===s)continue;const r=g.indexOf(s),i=e.get(t);i&&((b[r]??(b[r]=[])).push({ID:t.toString(),HELM:i}),(v[n]??(v[n]=[])).push(t))}(0,o.Xd)(v,g);const w=new Array(f);for(const e of b){const t=(await m(p.id,e,n,s,l,d)).Alignment;for(const e of t)w[parseInt(e.ID)]=Object.entries(e).filter((e=>!h.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.rs.SEPARATOR)}const C=r.Column.fromStrings(t,w);return C.setTag(r.TAGS.UNITS,i.r2.SEPARATOR),C.setTag(i.DX.separator,a.rs.SEPARATOR),C.setTag(i.DX.aligned,"SEQ.MSA"),C.setTag(i.DX.alphabet,i.fb.UN),C.setTag(i.DX.alphabetIsMultichar,"true"),C.semType=r.SEMTYPE.MACROMOLECULE,C}async function m(e,t,n,r,i,o){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${r}&gap_extend=${i}`;let u;if("fetchProxy"in s.dapi.docker.dockerContainers){const t=window.performance.now(),n=await s.dapi.docker.dockerContainers.fetchProxy(e,c,a),r=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${r-t} ms`);const i="application/json"===n.headers.get("content-type");if(!n.ok&&i){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const s=e["datagrok-error"];if(s)throw new Error(`Datagrok error: ${s}`);throw new Error(n.statusText)}if(!n.ok&&!i){const e=await n.text();throw new Error(`Error: ${e}`)}if(!i){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await s.dapi.docker.dockerContainers.request(e,c,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const r=u["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];o?.warning(e)}return u}},9943:(e,t,n)=>{"use strict";n.d(t,{C2:()=>u});var s=n(976),r=n(3870),i=n(4469),o=n(6414),a=n.n(o),l=n(8607);const c=60;function u(){const e=i.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==s.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),o=n?[n.name]:[],u=r.multiChoiceInput("Seq id columns",o,t.map((e=>e.name))),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const t=e.column;return!(!t||t.semType!==s.SEMTYPE.MACROMOLECULE)&&l.g.forColumn(t).isFasta()})).toArray(),m=d.length>0?d[0].name:[],p=r.choiceInput("Seq column",m,d.map((e=>e.name))),f=r.intInput("FASTA line width",c);r.dialog({title:"Save as FASTA"}).add(r.inputs([u,p,f])).onOK((()=>{const t=u.value?u.value.map((t=>e.columns.byName(t).column)):[],n=p.value?e.columns.byName(p.value).column:null,s=f.value??c;n||i.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(e,t,n=c,s="\n"){const r=l.g.forColumn(t),i=[];for(let o=0;o<t.length;o++){const t=e.map((e=>e.get(o).toString())).join("|"),a=h(r.getSplitted(o),n);i.push(`>${t}${s}`);for(const e of a)i.push(`${e}${s}`)}return"".concat(...i)}(t,n,s),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),o.setAttribute("download",`${e.dataFrame.name}.fasta`),o.click()})).show()}function h(e,t=c){let n=0;const s=e.length,r=[];for(;n<s;){const s=a()(e.originals).slice(n,n+t).toArray(),i=s.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");r.push(i),n+=s.length}return r}},9416:(e,t,n)=>{"use strict";n.d(t,{n:()=>u});var s=n(4469),r=n(976),i=n(2997),o=n(2568),a=n(8457),l=n(3553),c=n(1821);async function u(e,t){if(await(0,i.gw)(10),!(0,o.n)(t,"Sequence space"))return e;const n=(0,a.O)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=l.Of.MONOMER,e.setTag(c.DX.alphabet,t.getTag(c.DX.alphabet));const h=/(\d+)(?: \((\d+)\))?/,d=e=>{h.lastIndex=0;const t=e.match(h);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const s=n.columns.byIndex(e);s.semType=l.Of.MONOMER,s.setTag(c.DX.alphabet,t.getTag(c.DX.alphabet));const r=100;let i=0;for(;u.columns.byName(s.name)&&i<r;)s.name=d(s.name),i++;u.columns.add(s)}await s.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(r.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4293:(e,t,n)=>{"use strict";n.d(t,{B:()=>i,Y:()=>o});var s=n(4469),r=n(976);function i(){const e=s.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);if(null!==e)return e;s.shell.error("Current table does not contain macromolecules")}function o(e,t){e.innerHTML="",e.append(t)}},8415:(e,t,n)=>{"use strict";n.d(t,{bo:()=>v,OZ:()=>I});var s=n(4469),r=n(3870),i=n(976),o=n(3336),a=n.n(o),l=n(6414),c=n.n(l),u=n(701),h=n(8607),d=n(8447),m=n(9298);function p(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?p(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var f=n(6286),g=n(2997),y=n(172);var b,v,w=n(8770),C=n(9644);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new i.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},i.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class A{constructor(e=0,t){this.valueList=null,this.valueIdx=0,this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{get label(){return this._label?this._label:this.name}constructor(e,t,n,s){this.pos=e,this.name=t,this.sumRowCount=0,this._freqs=n??{},s?.sumRowCount&&(this.sumRowCount=s.sumRowCount),s?.sumValueForHeight&&(this.sumPlotValue=s.sumValueForHeight),s?.label&&(this._label=s.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?i.Column.fromFloat32Array(n,e):e instanceof Int32Array?i.Column.fromInt32Array(n,e):i.Column.fromList(i.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===m.ES.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const s=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-s*Math.log2(s)}}else if(e===m.ES.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,s,r,o,a,l,c){const u=s===m.ES.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let h=c*l+(n-u-1);const d=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f.G2&&t[0]!==f.G2?t[1].value-e[1].value:e[0]===f.G2&&t[0]===f.G2?0:e[0]===f.G2?-1:1));for(const[n,s]of d){const n=u*s.plotValue/this.sumPlotValue;s.bounds=new i.Rect((e-t)*l*o,h,a*l,n),h+=n}}render(e,t,n,s,r){for(const[i,o]of Object.entries(this._freqs))if(i!==f.G2){const a=(0,d.GU)(i,5),l=o.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=r.get(i)??r.get("other"),e.textAlign="left",e.font=t;const u=e.measureText(a);e.setTransform(l.width/u.width,0,0,l.height/s,c,l.top),e.fillText(a,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,s])=>s.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w._)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(v||(v={}));const x=m.vS;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const T=new class{constructor(){this.render=20}};class I extends i.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===m.dE.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===m.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.initialized=!1,this.palette=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewerId=++I.viewerCounter,this.setDataInProgress=!1,this.viewSubs=[],this.lastSize={width:-1,height:-1},this._onSizeChanged=new u.Subject,this._onFreqsCalculated=new u.Subject,this._onLayoutCalculated=new u.Subject,this.requestedRenderLevel=E.Freqs,this.renderRequest=new u.Subject,this._onRendered=new u.Subject,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA});const e=[i.AGG.KEY,i.AGG.PIVOT,i.AGG.MISSING_VALUE_COUNT,i.AGG.SKEW,i.AGG.KURT,i.AGG.SELECTED_ROWS_COUNT],t=Object.values(i.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(m.ES)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(m.vw)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(m.iD)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(m.dE)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(m.Ct)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.c(C._package.logger)}toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(i.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=h.g.forColumn(this.seqCol),this.palette=(0,d.dQ)(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case m.Ct.Filtered:e=this.dataFrame.filter;break;case m.Ct.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=m.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),s=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${s}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${s}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${s+6}px`),this.host.style.width=`${this.host}px`;const r=t>s;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=s*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),s=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,i=Math.max(1,Math.min(s,r));this._positionWidth=this.positionWidth*i,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=i*n,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=o>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,s=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[s];if(!r)return[null,null,null];const i=r.getMonomerAt(n,e.y);return void 0===i?[r,null,null]:[r,i,r.getFreq(i)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f.G2)||e.getFreq(f.G2).rowCount!==e.sumRowCount)).toArray())}render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(d.DX.positionNames),t=this.seqCol.getTag(d.DX.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(d.CI).indexOf(this.endPositionName),n=-1!==n?n:void 0);const s=this.getFilter(),r=0===s.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return s.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(d.CI).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(d.CI).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const o=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=h.g.forColumn(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<o;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}const l=this.dataFrame.rowCount;for(let e=0;e<o;++e){for(let t=0;t<l;++t)if(s.get(t)){const n=this.seqHandler.getSplitted(t),s=e<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===s?f.G2:s,i=this.positions[e],o=i.getFreq(r);++i.sumRowCount,o.value=++o.rowCount}if(this.valueAggrType===i.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(let n=0;n<l;++n)if(s.get(n)){const s=this.seqHandler.getSplitted(n).getCanonical(this.startPosition+e),r=t.get(n);this.positions[e].getFreq(s).push(r)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===i.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<o;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),o=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const o=this.canvas.height-r*n;let a;if(this.valueAggrType===i.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==m.ES.Entropy&&null==e&&s.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let s=e;s<=t;++s)s in this.positions?this.positions[s].calcScreen(s,this.slider.min,o,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${s}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,o,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=i.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,s,r,i,o,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(o);t<=Math.floor(a);t++){const n=i[t],s=e.measureText(n.name),r=s.actualBoundingBoxDescent-s.actualBoundingBoxAscent;l=null===l?s.width:Math.max(l,s.width),c=null===c?r:Math.max(c,r)}const u=l<s*t-2?1:(s*t-2)/l;for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=i[l],h=(l-o)*n*t+s*t/2,d=(r*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const s="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=o;e++)this.positions[e].render(a,s,l,c,this.palette)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}getAlphabetSize(){return this.seqHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===m.Ct.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===m.Ct.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const n=e,s=this.canvas.getCursorPosition(n,t),[o,a]=this.getMonomer(s,t),l=this.showPositionLabels?12*t:0;if(null!==o&&null===a&&0<=s.y&&s.y<=l){const e=[r.divText(`Position ${o.label}`)];this.valueAggrType===i.AGG.TOTAL_COUNT&&e.push(o.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==o&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==i.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const s=r.divV(t);r.tooltip.show(s,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[s,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==s&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=i.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,s,r,i){const o=t.getSplitted(s),a=i.pos<o.length?o.getCanonical(i.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,s)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),s=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+s)}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}I.residuesSet="nucleotides",I.viewerCounter=-1},8755:(e,t,n)=>{"use strict";n.d(t,{Y:()=>o,x:()=>i});var s=n(701),r=n(9644);class i{constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{constructor(){this.onChanged=new s.Subject,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},5393:(e,t,n)=>{"use strict";n.d(t,{ST:()=>x});var s=n(3870),r=n(976),i=n(4469),o=n(6414),a=n.n(o),l=n(701),c=n(8447),u=n(2997),h=n(8607),d=n(172),m=n(7983),p=n(8755),f=n(3336),g=n.n(f),y=n(7945),b=n(4293),v=n(9644);class w extends p.Y{viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this._filterPanel=s.div("",{style:{cursor:"pointer"}}),this.viewerId=++w.viewerCounter,this.viewSubs=[],this.logger=v._package.logger}async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await async function(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await s.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=s.div(),n=e.createWebEditorApp(t,this.props.substructure),s.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.x(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(s.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.yf)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.yf)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),s.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=s.divText("Click to edit","helm-substructure-filter");(0,b.Y)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.gw)(10),await(0,m.QF)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}w.viewerCounter=-1;const C="bio-substructure-filter";class A{constructor(e,t,n,s,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=s,this.bitset=r}}class S extends p.x{constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class x extends r.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.bioFilter=null,this.bitset=null,this.notation=void 0,this.filterId=++x.filterCounter,this.viewSubs=[],this._onRendered=new l.Subject,this.root=s.divV([]),this.loader=s.loader(),this.calculating=!1,this.filterSyncer=new d.c(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),h.g.forColumn(this.column),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(r.TAGS.UNITS)),this.bioFilter=this.notation===c.r2.FASTA?new E:this.notation===c.r2.SEPARATOR?new T(this.column.getTag(c.DX.separator)):new w,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(i.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(i.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),i.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.gw)(10),await(0,u.zg)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const s=this.filterSyncer.resetErrors();if(s.length>0)throw s[0]}}x.filterCounter=-1;class E extends p.Y{get type(){return"FastaBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this.substructureInput=s.stringInput("","",(()=>{this.props=new p.x(this.substructureInput.value),this._propsChanging||this.onChanged.next()}),{placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,m.pf)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class T extends p.Y{get type(){return"SeparatorBioFilter"}constructor(e){super(),this.emptyProps=new S("",void 0),this.colSeparator="",this.substructureInput=s.stringInput("","",(()=>{this.props=new S(this.substructureInput.value,this.props.separator),this._propsChanging||this.onChanged.next()}),{placeholder:"Substructure"}),this.separatorInput=s.stringInput("",this.colSeparator=e,(()=>{const e=this.separatorInput.value?this.separatorInput.value:void 0;this.props=new S(this.props.substructure,e),this._propsChanging||this.onChanged.next()}),{placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("")}get filterPanel(){return s.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,m.pf)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},8770:(e,t,n)=>{"use strict";n.d(t,{_:()=>T,t:()=>E});var s=n(3870),r=n(976),i=n(6414),o=n.n(i),a=n(8447),l=n(7331),c=n(3379),u=n.n(c),h=n(7795),d=n.n(h),m=n(569),p=n.n(m),f=n(3565),g=n.n(f),y=n(9216),b=n.n(y),v=n(4589),w=n.n(v),C=n(5362),A={};A.styleTagTransform=w(),A.setAttributes=g(),A.insert=p().bind(null,"head"),A.domAPI=d(),A.insertStyleElement=b(),u()(C.Z,A),C.Z&&C.Z.locals&&C.Z.locals;var S=n(8607),x=n(6286);function E(e){const t=s.div();t.classList.add("macromolecule-cell-comp-analysis-host");const n=e.cell.column.tags[a.DX.alphabet];let i=l.UE.Color;switch(n){case a.fb.DNA:case a.fb.RNA:i=(0,a.py)(a.fb.DNA);break;case a.fb.PT:i=(0,a.py)(a.fb.PT)}const c={},u=S.g.forColumn(e.cell.column),h=e.cell.rowIndex,d=u.getSplitted(h);o()(d.canonicals).filter((e=>e!==x.G2)).forEach((e=>{const t=c[e]||0;c[e]=t+1}));const m=T(i,c);return Array.from(m.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),t.appendChild(m),new r.Widget(t)}function T(e,t){let n=0,i=null;for(const e of Object.values(t))n+=e,i=null===i?e:Math.max(i,e);const o=i/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,i])=>{const a=i/n,l=e.get(t),c=s.div("",{classes:"macromolecule-cell-comp-analysis-bar"});c.style.width=50*a/o+"px",c.style.backgroundColor=l,x.G2===t&&(c.style.borderWidth="1px",c.style.borderStyle="solid",c.style.borderColor=r.Color.toHtml(r.Color.lightGray));const u=x.G2===t?"-":t,h=s.div(`${(100*a).toFixed(2)}%`);return{[u]:s.div([c,h],{classes:"macromolecule-cell-comp-analysis-value"})}}))),l=s.tableFromMap(a);return Array.from(l.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),l}},540:function(e,t){!function(e){"use strict";function t(){for(var e=arguments.length,t=Array(e),n=0;n<e;n++)t[n]=arguments[n];if(t.length>1){t[0]=t[0].slice(0,-1);for(var s=t.length-1,r=1;r<s;++r)t[r]=t[r].slice(1,-1);return t[s]=t[s].slice(1),t.join("")}return t[0]}function n(e){return"(?:"+e+")"}function s(e){return void 0===e?"undefined":null===e?"null":Object.prototype.toString.call(e).split(" ").pop().split("]").shift().toLowerCase()}function r(e){return e.toUpperCase()}function i(e){var s="[A-Za-z]",r="[0-9]",i=t(r,"[A-Fa-f]"),o=n(n("%[EFef]"+i+"%"+i+i+"%"+i+i)+"|"+n("%[89A-Fa-f]"+i+"%"+i+i)+"|"+n("%"+i+i)),a="[\\!\\$\\&\\'\\(\\)\\*\\+\\,\\;\\=]",l=t("[\\:\\/\\?\\#\\[\\]\\@]",a),c=e?"[\\uE000-\\uF8FF]":"[]",u=t(s,r,"[\\-\\.\\_\\~]",e?"[\\xA0-\\u200D\\u2010-\\u2029\\u202F-\\uD7FF\\uF900-\\uFDCF\\uFDF0-\\uFFEF]":"[]"),h=n(s+t(s,r,"[\\+\\-\\.]")+"*"),d=n(n(o+"|"+t(u,a,"[\\:]"))+"*"),m=(n(n("25[0-5]")+"|"+n("2[0-4]"+r)+"|"+n("1"+r+r)+"|"+n("[1-9]"+r)+"|"+r),n(n("25[0-5]")+"|"+n("2[0-4]"+r)+"|"+n("1"+r+r)+"|"+n("0?[1-9]"+r)+"|0?0?"+r)),p=n(m+"\\."+m+"\\."+m+"\\."+m),f=n(i+"{1,4}"),g=n(n(f+"\\:"+f)+"|"+p),y=n(n(f+"\\:")+"{6}"+g),b=n("\\:\\:"+n(f+"\\:")+"{5}"+g),v=n(n(f)+"?\\:\\:"+n(f+"\\:")+"{4}"+g),w=n(n(n(f+"\\:")+"{0,1}"+f)+"?\\:\\:"+n(f+"\\:")+"{3}"+g),C=n(n(n(f+"\\:")+"{0,2}"+f)+"?\\:\\:"+n(f+"\\:")+"{2}"+g),A=n(n(n(f+"\\:")+"{0,3}"+f)+"?\\:\\:"+f+"\\:"+g),S=n(n(n(f+"\\:")+"{0,4}"+f)+"?\\:\\:"+g),x=n(n(n(f+"\\:")+"{0,5}"+f)+"?\\:\\:"+f),E=n(n(n(f+"\\:")+"{0,6}"+f)+"?\\:\\:"),T=n([y,b,v,w,C,A,S,x,E].join("|")),I=n(n(u+"|"+o)+"+"),_=(n(T+"\\%25"+I),n(T+n("\\%25|\\%(?!"+i+"{2})")+I)),M=n("[vV]"+i+"+\\."+t(u,a,"[\\:]")+"+"),$=n("\\["+n(_+"|"+T+"|"+M)+"\\]"),N=n(n(o+"|"+t(u,a))+"*"),L=n($+"|"+p+"(?!"+N+")|"+N),P=n(r+"*"),R=n(n(d+"@")+"?"+L+n("\\:"+P)+"?"),O=n(o+"|"+t(u,a,"[\\:\\@]")),k=n(O+"*"),D=n(O+"+"),F=n(n(o+"|"+t(u,a,"[\\@]"))+"+"),G=n(n("\\/"+k)+"*"),B=n("\\/"+n(D+G)+"?"),V=n(F+G),U=n(D+G),H="(?!"+O+")",j=(n(G+"|"+B+"|"+V+"|"+U+"|"+H),n(n(O+"|"+t("[\\/\\?]",c))+"*")),W=n(n(O+"|[\\/\\?]")+"*"),Y=n(n("\\/\\/"+R+G)+"|"+B+"|"+U+"|"+H),Z=n(h+"\\:"+Y+n("\\?"+j)+"?"+n("\\#"+W)+"?"),q=n(n("\\/\\/"+R+G)+"|"+B+"|"+V+"|"+H),K=n(q+n("\\?"+j)+"?"+n("\\#"+W)+"?");return n(Z+"|"+K),n(h+"\\:"+Y+n("\\?"+j)+"?"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+U+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+V+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+U+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n("("+d+")@"),n("\\:("+P+")"),{NOT_SCHEME:new RegExp(t("[^]",s,r,"[\\+\\-\\.]"),"g"),NOT_USERINFO:new RegExp(t("[^\\%\\:]",u,a),"g"),NOT_HOST:new RegExp(t("[^\\%\\[\\]\\:]",u,a),"g"),NOT_PATH:new RegExp(t("[^\\%\\/\\:\\@]",u,a),"g"),NOT_PATH_NOSCHEME:new RegExp(t("[^\\%\\/\\@]",u,a),"g"),NOT_QUERY:new RegExp(t("[^\\%]",u,a,"[\\:\\@\\/\\?]",c),"g"),NOT_FRAGMENT:new RegExp(t("[^\\%]",u,a,"[\\:\\@\\/\\?]"),"g"),ESCAPE:new RegExp(t("[^]",u,a),"g"),UNRESERVED:new RegExp(u,"g"),OTHER_CHARS:new RegExp(t("[^\\%]",u,l),"g"),PCT_ENCODED:new RegExp(o,"g"),IPV4ADDRESS:new RegExp("^("+p+")$"),IPV6ADDRESS:new RegExp("^\\[?("+T+")"+n(n("\\%25|\\%(?!"+i+"{2})")+"("+I+")")+"?\\]?$")}}var o=i(!1),a=i(!0),l=function(e,t){if(Array.isArray(e))return e;if(Symbol.iterator in Object(e))return function(e,t){var n=[],s=!0,r=!1,i=void 0;try{for(var o,a=e[Symbol.iterator]();!(s=(o=a.next()).done)&&(n.push(o.value),!t||n.length!==t);s=!0);}catch(e){r=!0,i=e}finally{try{!s&&a.return&&a.return()}finally{if(r)throw i}}return n}(e,t);throw new TypeError("Invalid attempt to destructure non-iterable instance")},c=2147483647,u=36,h=/^xn--/,d=/[^\0-\x7E]/,m=/[\x2E\u3002\uFF0E\uFF61]/g,p={overflow:"Overflow: input needs wider integers to process","not-basic":"Illegal input >= 0x80 (not a basic code point)","invalid-input":"Invalid input"},f=Math.floor,g=String.fromCharCode;function y(e){throw new RangeError(p[e])}function b(e,t){var n=e.split("@"),s="";return n.length>1&&(s=n[0]+"@",e=n[1]),s+function(e,t){for(var n=[],s=e.length;s--;)n[s]=t(e[s]);return n}((e=e.replace(m,".")).split("."),t).join(".")}function v(e){for(var t=[],n=0,s=e.length;n<s;){var r=e.charCodeAt(n++);if(r>=55296&&r<=56319&&n<s){var i=e.charCodeAt(n++);56320==(64512&i)?t.push(((1023&r)<<10)+(1023&i)+65536):(t.push(r),n--)}else t.push(r)}return t}var w=function(e,t){return e+22+75*(e<26)-((0!=t)<<5)},C=function(e,t,n){var s=0;for(e=n?f(e/700):e>>1,e+=f(e/t);e>455;s+=u)e=f(e/35);return f(s+36*e/(e+38))},A=function(e){var t,n=[],s=e.length,r=0,i=128,o=72,a=e.lastIndexOf("-");a<0&&(a=0);for(var l=0;l<a;++l)e.charCodeAt(l)>=128&&y("not-basic"),n.push(e.charCodeAt(l));for(var h=a>0?a+1:0;h<s;){for(var d=r,m=1,p=u;;p+=u){h>=s&&y("invalid-input");var g=(t=e.charCodeAt(h++))-48<10?t-22:t-65<26?t-65:t-97<26?t-97:u;(g>=u||g>f((c-r)/m))&&y("overflow"),r+=g*m;var b=p<=o?1:p>=o+26?26:p-o;if(g<b)break;var v=u-b;m>f(c/v)&&y("overflow"),m*=v}var w=n.length+1;o=C(r-d,w,0==d),f(r/w)>c-i&&y("overflow"),i+=f(r/w),r%=w,n.splice(r++,0,i)}return String.fromCodePoint.apply(String,n)},S=function(e){var t=[],n=(e=v(e)).length,s=128,r=0,i=72,o=!0,a=!1,l=void 0;try{for(var h,d=e[Symbol.iterator]();!(o=(h=d.next()).done);o=!0){var m=h.value;m<128&&t.push(g(m))}}catch(e){a=!0,l=e}finally{try{!o&&d.return&&d.return()}finally{if(a)throw l}}var p=t.length,b=p;for(p&&t.push("-");b<n;){var A=c,S=!0,x=!1,E=void 0;try{for(var T,I=e[Symbol.iterator]();!(S=(T=I.next()).done);S=!0){var _=T.value;_>=s&&_<A&&(A=_)}}catch(e){x=!0,E=e}finally{try{!S&&I.return&&I.return()}finally{if(x)throw E}}var M=b+1;A-s>f((c-r)/M)&&y("overflow"),r+=(A-s)*M,s=A;var $=!0,N=!1,L=void 0;try{for(var P,R=e[Symbol.iterator]();!($=(P=R.next()).done);$=!0){var O=P.value;if(O<s&&++r>c&&y("overflow"),O==s){for(var k=r,D=u;;D+=u){var F=D<=i?1:D>=i+26?26:D-i;if(k<F)break;var G=k-F,B=u-F;t.push(g(w(F+G%B,0))),k=f(G/B)}t.push(g(w(k,0))),i=C(r,M,b==p),r=0,++b}}}catch(e){N=!0,L=e}finally{try{!$&&R.return&&R.return()}finally{if(N)throw L}}++r,++s}return t.join("")},x={version:"2.1.0",ucs2:{decode:v,encode:function(e){return String.fromCodePoint.apply(String,function(e){if(Array.isArray(e)){for(var t=0,n=Array(e.length);t<e.length;t++)n[t]=e[t];return n}return Array.from(e)}(e))}},decode:A,encode:S,toASCII:function(e){return b(e,(function(e){return d.test(e)?"xn--"+S(e):e}))},toUnicode:function(e){return b(e,(function(e){return h.test(e)?A(e.slice(4).toLowerCase()):e}))}},E={};function T(e){var t=e.charCodeAt(0);return t<16?"%0"+t.toString(16).toUpperCase():t<128?"%"+t.toString(16).toUpperCase():t<2048?"%"+(t>>6|192).toString(16).toUpperCase()+"%"+(63&t|128).toString(16).toUpperCase():"%"+(t>>12|224).toString(16).toUpperCase()+"%"+(t>>6&63|128).toString(16).toUpperCase()+"%"+(63&t|128).toString(16).toUpperCase()}function I(e){for(var t="",n=0,s=e.length;n<s;){var r=parseInt(e.substr(n+1,2),16);if(r<128)t+=String.fromCharCode(r),n+=3;else if(r>=194&&r<224){if(s-n>=6){var i=parseInt(e.substr(n+4,2),16);t+=String.fromCharCode((31&r)<<6|63&i)}else t+=e.substr(n,6);n+=6}else if(r>=224){if(s-n>=9){var o=parseInt(e.substr(n+4,2),16),a=parseInt(e.substr(n+7,2),16);t+=String.fromCharCode((15&r)<<12|(63&o)<<6|63&a)}else t+=e.substr(n,9);n+=9}else t+=e.substr(n,3),n+=3}return t}function _(e,t){function n(e){var n=I(e);return n.match(t.UNRESERVED)?n:e}return e.scheme&&(e.scheme=String(e.scheme).replace(t.PCT_ENCODED,n).toLowerCase().replace(t.NOT_SCHEME,"")),void 0!==e.userinfo&&(e.userinfo=String(e.userinfo).replace(t.PCT_ENCODED,n).replace(t.NOT_USERINFO,T).replace(t.PCT_ENCODED,r)),void 0!==e.host&&(e.host=String(e.host).replace(t.PCT_ENCODED,n).toLowerCase().replace(t.NOT_HOST,T).replace(t.PCT_ENCODED,r)),void 0!==e.path&&(e.path=String(e.path).replace(t.PCT_ENCODED,n).replace(e.scheme?t.NOT_PATH:t.NOT_PATH_NOSCHEME,T).replace(t.PCT_ENCODED,r)),void 0!==e.query&&(e.query=String(e.query).replace(t.PCT_ENCODED,n).replace(t.NOT_QUERY,T).replace(t.PCT_ENCODED,r)),void 0!==e.fragment&&(e.fragment=String(e.fragment).replace(t.PCT_ENCODED,n).replace(t.NOT_FRAGMENT,T).replace(t.PCT_ENCODED,r)),e}function M(e){return e.replace(/^0*(.*)/,"$1")||"0"}function $(e,t){var n=e.match(t.IPV4ADDRESS)||[],s=l(n,2)[1];return s?s.split(".").map(M).join("."):e}function N(e,t){var n=e.match(t.IPV6ADDRESS)||[],s=l(n,3),r=s[1],i=s[2];if(r){for(var o=r.toLowerCase().split("::").reverse(),a=l(o,2),c=a[0],u=a[1],h=u?u.split(":").map(M):[],d=c.split(":").map(M),m=t.IPV4ADDRESS.test(d[d.length-1]),p=m?7:8,f=d.length-p,g=Array(p),y=0;y<p;++y)g[y]=h[y]||d[f+y]||"";m&&(g[p-1]=$(g[p-1],t));var b=g.reduce((function(e,t,n){if(!t||"0"===t){var s=e[e.length-1];s&&s.index+s.length===n?s.length++:e.push({index:n,length:1})}return e}),[]).sort((function(e,t){return t.length-e.length}))[0],v=void 0;if(b&&b.length>1){var w=g.slice(0,b.index),C=g.slice(b.index+b.length);v=w.join(":")+"::"+C.join(":")}else v=g.join(":");return i&&(v+="%"+i),v}return e}var L=/^(?:([^:\/?#]+):)?(?:\/\/((?:([^\/?#@]*)@)?(\[[^\/?#\]]+\]|[^\/?#:]*)(?:\:(\d*))?))?([^?#]*)(?:\?([^#]*))?(?:#((?:.|\n|\r)*))?/i,P=void 0==="".match(/(){0}/)[1];function R(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n={},s=!1!==t.iri?a:o;"suffix"===t.reference&&(e=(t.scheme?t.scheme+":":"")+"//"+e);var r=e.match(L);if(r){P?(n.scheme=r[1],n.userinfo=r[3],n.host=r[4],n.port=parseInt(r[5],10),n.path=r[6]||"",n.query=r[7],n.fragment=r[8],isNaN(n.port)&&(n.port=r[5])):(n.scheme=r[1]||void 0,n.userinfo=-1!==e.indexOf("@")?r[3]:void 0,n.host=-1!==e.indexOf("//")?r[4]:void 0,n.port=parseInt(r[5],10),n.path=r[6]||"",n.query=-1!==e.indexOf("?")?r[7]:void 0,n.fragment=-1!==e.indexOf("#")?r[8]:void 0,isNaN(n.port)&&(n.port=e.match(/\/\/(?:.|\n)*\:(?:\/|\?|\#|$)/)?r[4]:void 0)),n.host&&(n.host=N($(n.host,s),s)),void 0!==n.scheme||void 0!==n.userinfo||void 0!==n.host||void 0!==n.port||n.path||void 0!==n.query?void 0===n.scheme?n.reference="relative":void 0===n.fragment?n.reference="absolute":n.reference="uri":n.reference="same-document",t.reference&&"suffix"!==t.reference&&t.reference!==n.reference&&(n.error=n.error||"URI is not a "+t.reference+" reference.");var i=E[(t.scheme||n.scheme||"").toLowerCase()];if(t.unicodeSupport||i&&i.unicodeSupport)_(n,s);else{if(n.host&&(t.domainHost||i&&i.domainHost))try{n.host=x.toASCII(n.host.replace(s.PCT_ENCODED,I).toLowerCase())}catch(e){n.error=n.error||"Host's domain name can not be converted to ASCII via punycode: "+e}_(n,o)}i&&i.parse&&i.parse(n,t)}else n.error=n.error||"URI can not be parsed.";return n}var O=/^\.\.?\//,k=/^\/\.(\/|$)/,D=/^\/\.\.(\/|$)/,F=/^\/?(?:.|\n)*?(?=\/|$)/;function G(e){for(var t=[];e.length;)if(e.match(O))e=e.replace(O,"");else if(e.match(k))e=e.replace(k,"/");else if(e.match(D))e=e.replace(D,"/"),t.pop();else if("."===e||".."===e)e="";else{var n=e.match(F);if(!n)throw new Error("Unexpected dot segment condition");var s=n[0];e=e.slice(s.length),t.push(s)}return t.join("")}function B(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=t.iri?a:o,s=[],r=E[(t.scheme||e.scheme||"").toLowerCase()];if(r&&r.serialize&&r.serialize(e,t),e.host)if(n.IPV6ADDRESS.test(e.host));else if(t.domainHost||r&&r.domainHost)try{e.host=t.iri?x.toUnicode(e.host):x.toASCII(e.host.replace(n.PCT_ENCODED,I).toLowerCase())}catch(n){e.error=e.error||"Host's domain name can not be converted to "+(t.iri?"Unicode":"ASCII")+" via punycode: "+n}_(e,n),"suffix"!==t.reference&&e.scheme&&(s.push(e.scheme),s.push(":"));var i=function(e,t){var n=!1!==t.iri?a:o,s=[];return void 0!==e.userinfo&&(s.push(e.userinfo),s.push("@")),void 0!==e.host&&s.push(N($(String(e.host),n),n).replace(n.IPV6ADDRESS,(function(e,t,n){return"["+t+(n?"%25"+n:"")+"]"}))),"number"!=typeof e.port&&"string"!=typeof e.port||(s.push(":"),s.push(String(e.port))),s.length?s.join(""):void 0}(e,t);if(void 0!==i&&("suffix"!==t.reference&&s.push("//"),s.push(i),e.path&&"/"!==e.path.charAt(0)&&s.push("/")),void 0!==e.path){var l=e.path;t.absolutePath||r&&r.absolutePath||(l=G(l)),void 0===i&&(l=l.replace(/^\/\//,"/%2F")),s.push(l)}return void 0!==e.query&&(s.push("?"),s.push(e.query)),void 0!==e.fragment&&(s.push("#"),s.push(e.fragment)),s.join("")}function V(e,t){var n=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},s={};return arguments[3]||(e=R(B(e,n),n),t=R(B(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(s.scheme=t.scheme,s.userinfo=t.userinfo,s.host=t.host,s.port=t.port,s.path=G(t.path||""),s.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(s.userinfo=t.userinfo,s.host=t.host,s.port=t.port,s.path=G(t.path||""),s.query=t.query):(t.path?("/"===t.path.charAt(0)?s.path=G(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?s.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:s.path=t.path:s.path="/"+t.path,s.path=G(s.path)),s.query=t.query):(s.path=e.path,void 0!==t.query?s.query=t.query:s.query=e.query),s.userinfo=e.userinfo,s.host=e.host,s.port=e.port),s.scheme=e.scheme),s.fragment=t.fragment,s}function U(e,t){return e&&e.toString().replace(t&&t.iri?a.PCT_ENCODED:o.PCT_ENCODED,I)}var H={scheme:"http",domainHost:!0,parse:function(e,t){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e},serialize:function(e,t){var n="https"===String(e.scheme).toLowerCase();return e.port!==(n?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}},j={scheme:"https",domainHost:H.domainHost,parse:H.parse,serialize:H.serialize};function W(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}var Y={scheme:"ws",domainHost:!0,parse:function(e,t){var n=e;return n.secure=W(n),n.resourceName=(n.path||"/")+(n.query?"?"+n.query:""),n.path=void 0,n.query=void 0,n},serialize:function(e,t){if(e.port!==(W(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){var n=e.resourceName.split("?"),s=l(n,2),r=s[0],i=s[1];e.path=r&&"/"!==r?r:void 0,e.query=i,e.resourceName=void 0}return e.fragment=void 0,e}},Z={scheme:"wss",domainHost:Y.domainHost,parse:Y.parse,serialize:Y.serialize},q={},K="[A-Za-z0-9\\-\\.\\_\\~\\xA0-\\u200D\\u2010-\\u2029\\u202F-\\uD7FF\\uF900-\\uFDCF\\uFDF0-\\uFFEF]",z="[0-9A-Fa-f]",X=n(n("%[EFef]"+z+"%"+z+z+"%"+z+z)+"|"+n("%[89A-Fa-f]"+z+"%"+z+z)+"|"+n("%"+z+z)),J=t("[\\!\\$\\%\\'\\(\\)\\*\\+\\,\\-\\.0-9\\<\\>A-Z\\x5E-\\x7E]",'[\\"\\\\]'),Q=new RegExp(K,"g"),ee=new RegExp(X,"g"),te=new RegExp(t("[^]","[A-Za-z0-9\\!\\$\\%\\'\\*\\+\\-\\^\\_\\`\\{\\|\\}\\~]","[\\.]",'[\\"]',J),"g"),ne=new RegExp(t("[^]",K,"[\\!\\$\\'\\(\\)\\*\\+\\,\\;\\:\\@]"),"g"),se=ne;function re(e){var t=I(e);return t.match(Q)?t:e}var ie={scheme:"mailto",parse:function(e,t){var n=e,s=n.to=n.path?n.path.split(","):[];if(n.path=void 0,n.query){for(var r=!1,i={},o=n.query.split("&"),a=0,l=o.length;a<l;++a){var c=o[a].split("=");switch(c[0]){case"to":for(var u=c[1].split(","),h=0,d=u.length;h<d;++h)s.push(u[h]);break;case"subject":n.subject=U(c[1],t);break;case"body":n.body=U(c[1],t);break;default:r=!0,i[U(c[0],t)]=U(c[1],t)}}r&&(n.headers=i)}n.query=void 0;for(var m=0,p=s.length;m<p;++m){var f=s[m].split("@");if(f[0]=U(f[0]),t.unicodeSupport)f[1]=U(f[1],t).toLowerCase();else try{f[1]=x.toASCII(U(f[1],t).toLowerCase())}catch(e){n.error=n.error||"Email address's domain name can not be converted to ASCII via punycode: "+e}s[m]=f.join("@")}return n},serialize:function(e,t){var n,s=e,i=null!=(n=e.to)?n instanceof Array?n:"number"!=typeof n.length||n.split||n.setInterval||n.call?[n]:Array.prototype.slice.call(n):[];if(i){for(var o=0,a=i.length;o<a;++o){var l=String(i[o]),c=l.lastIndexOf("@"),u=l.slice(0,c).replace(ee,re).replace(ee,r).replace(te,T),h=l.slice(c+1);try{h=t.iri?x.toUnicode(h):x.toASCII(U(h,t).toLowerCase())}catch(e){s.error=s.error||"Email address's domain name can not be converted to "+(t.iri?"Unicode":"ASCII")+" via punycode: "+e}i[o]=u+"@"+h}s.path=i.join(",")}var d=e.headers=e.headers||{};e.subject&&(d.subject=e.subject),e.body&&(d.body=e.body);var m=[];for(var p in d)d[p]!==q[p]&&m.push(p.replace(ee,re).replace(ee,r).replace(ne,T)+"="+d[p].replace(ee,re).replace(ee,r).replace(se,T));return m.length&&(s.query=m.join("&")),s}},oe=/^([^\:]+)\:(.*)/,ae={scheme:"urn",parse:function(e,t){var n=e.path&&e.path.match(oe),s=e;if(n){var r=t.scheme||s.scheme||"urn",i=n[1].toLowerCase(),o=n[2],a=r+":"+(t.nid||i),l=E[a];s.nid=i,s.nss=o,s.path=void 0,l&&(s=l.parse(s,t))}else s.error=s.error||"URN can not be parsed.";return s},serialize:function(e,t){var n=t.scheme||e.scheme||"urn",s=e.nid,r=n+":"+(t.nid||s),i=E[r];i&&(e=i.serialize(e,t));var o=e,a=e.nss;return o.path=(s||t.nid)+":"+a,o}},le=/^[0-9A-Fa-f]{8}(?:\-[0-9A-Fa-f]{4}){3}\-[0-9A-Fa-f]{12}$/,ce={scheme:"urn:uuid",parse:function(e,t){var n=e;return n.uuid=n.nss,n.nss=void 0,t.tolerant||n.uuid&&n.uuid.match(le)||(n.error=n.error||"UUID is not valid."),n},serialize:function(e,t){var n=e;return n.nss=(e.uuid||"").toLowerCase(),n}};E[H.scheme]=H,E[j.scheme]=j,E[Y.scheme]=Y,E[Z.scheme]=Z,E[ie.scheme]=ie,E[ae.scheme]=ae,E[ce.scheme]=ce,e.SCHEMES=E,e.pctEncChar=T,e.pctDecChars=I,e.parse=R,e.removeDotSegments=G,e.serialize=B,e.resolveComponents=V,e.resolve=function(e,t,n){var s=function(e,t){var n=e;if(t)for(var s in t)n[s]=t[s];return n}({scheme:"null"},n);return B(V(R(e,s),R(t,s),s,!0),s)},e.normalize=function(e,t){return"string"==typeof e?e=B(R(e,t),t):"object"===s(e)&&(e=R(B(e,t),t)),e},e.equal=function(e,t,n){return"string"==typeof e?e=B(R(e,n),n):"object"===s(e)&&(e=B(e,n)),"string"==typeof t?t=B(R(t,n),n):"object"===s(t)&&(t=B(t,n)),e===t},e.escapeComponent=function(e,t){return e&&e.toString().replace(t&&t.iri?a.ESCAPE:o.ESCAPE,T)},e.unescapeComponent=U,Object.defineProperty(e,"__esModule",{value:!0})}(t)},3336:e=>{"use strict";e.exports=$},976:e=>{"use strict";e.exports=DG},4469:e=>{"use strict";e.exports=grok},701:e=>{"use strict";e.exports=rxjs},3870:e=>{"use strict";e.exports=ui},6414:e=>{"use strict";e.exports=wu},4775:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},996:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},6795:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},235:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},2567:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},1233:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},5568:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},1968:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},2577:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},98:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(s){var r=t[s];if(void 0!==r)return r.exports;var i=t[s]={id:s,loaded:!1,exports:{}};return e[s].call(i.exports,i,i.exports,n),i.loaded=!0,i.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var s in t)n.o(t,s)&&!n.o(e,s)&&Object.defineProperty(e,s,{enumerable:!0,get:t[s]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&(e=t.currentScript.src),!e)){var s=t.getElementsByTagName("script");if(s.length)for(var r=s.length-1;r>-1&&!e;)e=s[r--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var s=n(9644);bio=s})();
8
+ deps: ${n}}`};const o={keyword:"dependencies",type:"object",schemaType:"object",error:t.error,code(e){const[t,n]=function({schema:e}){const t={},n={};for(const s in e)"__proto__"!==s&&((Array.isArray(e[s])?t:n)[s]=e[s]);return[t,n]}(e);a(e,t),l(e,n)}};function a(e,t=e.schema){const{gen:n,data:r,it:o}=e;if(0===Object.keys(t).length)return;const a=n.let("missing");for(const l in t){const c=t[l];if(0===c.length)continue;const u=(0,i.propertyInData)(n,r,l,o.opts.ownProperties);e.setParams({property:l,depsCount:c.length,deps:c.join(", ")}),o.allErrors?n.if(u,(()=>{for(const t of c)(0,i.checkReportMissingProp)(e,t)})):(n.if(s._`${u} && (${(0,i.checkMissingProp)(e,c,a)})`),(0,i.reportMissingProp)(e,a),n.else())}}function l(e,t=e.schema){const{gen:n,data:s,keyword:o,it:a}=e,l=n.name("valid");for(const c in t)(0,r.alwaysValidSchema)(a,t[c])||(n.if((0,i.propertyInData)(n,s,c,a.opts.ownProperties),(()=>{const t=e.subschema({keyword:o,schemaProp:c},l);e.mergeValidEvaluated(t,l)}),(()=>n.var(l,!0))),e.ok(l))}t.validatePropertyDeps=a,t.validateSchemaDeps=l,t.default=o},7274:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(7772),r={keyword:"dependentSchemas",type:"object",schemaType:"object",code:e=>(0,s.validateSchemaDeps)(e)};t.default=r},9434:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"if",schemaType:["object","boolean"],trackErrors:!0,error:{message:({params:e})=>s.str`must match "${e.ifClause}" schema`,params:({params:e})=>s._`{failingKeyword: ${e.ifClause}}`},code(e){const{gen:t,parentSchema:n,it:i}=e;void 0===n.then&&void 0===n.else&&(0,r.checkStrictMode)(i,'"if" without "then" and "else" is ignored');const a=o(i,"then"),l=o(i,"else");if(!a&&!l)return;const c=t.let("valid",!0),u=t.name("_valid");if(function(){const t=e.subschema({keyword:"if",compositeRule:!0,createErrors:!1,allErrors:!1},u);e.mergeEvaluated(t)}(),e.reset(),a&&l){const n=t.let("ifClause");e.setParams({ifClause:n}),t.if(u,h("then",n),h("else",n))}else a?t.if(u,h("then")):t.if((0,s.not)(u),h("else"));function h(n,r){return()=>{const i=e.subschema({keyword:n},u);t.assign(c,u),e.mergeValidEvaluated(i,c),r?t.assign(r,s._`${n}`):e.setParams({ifClause:n})}}e.pass(c,(()=>e.error(!0)))}};function o(e,t){const n=e.schema[t];return void 0!==n&&!(0,r.alwaysValidSchema)(e,n)}t.default=i},8200:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4783),r=n(2924),i=n(4665),o=n(1119),a=n(9864),l=n(7772),c=n(3708),u=n(9351),h=n(6239),d=n(2296),m=n(2182),p=n(19),f=n(4200),g=n(1125),y=n(9434),b=n(6552);t.default=function(e=!1){const t=[m.default,p.default,f.default,g.default,y.default,b.default,c.default,u.default,l.default,h.default,d.default];return e?t.push(r.default,o.default):t.push(s.default,i.default),t.push(a.default),t}},4665:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateTuple=void 0;const s=n(3487),r=n(6776),i=n(412),o={keyword:"items",type:"array",schemaType:["object","array","boolean"],before:"uniqueItems",code(e){const{schema:t,it:n}=e;if(Array.isArray(t))return a(e,"additionalItems",t);n.items=!0,(0,r.alwaysValidSchema)(n,t)||e.ok((0,i.validateArray)(e))}};function a(e,t,n=e.schema){const{gen:i,parentSchema:o,data:a,keyword:l,it:c}=e;!function(e){const{opts:s,errSchemaPath:i}=c,o=n.length,a=o===e.minItems&&(o===e.maxItems||!1===e[t]);if(s.strictTuples&&!a){const e=`"${l}" is ${o}-tuple, but minItems or maxItems/${t} are not specified or different at path "${i}"`;(0,r.checkStrictMode)(c,e,s.strictTuples)}}(o),c.opts.unevaluated&&n.length&&!0!==c.items&&(c.items=r.mergeEvaluated.items(i,n.length,c.items));const u=i.name("valid"),h=i.const("len",s._`${a}.length`);n.forEach(((t,n)=>{(0,r.alwaysValidSchema)(c,t)||(i.if(s._`${h} > ${n}`,(()=>e.subschema({keyword:l,schemaProp:n,dataProp:n},u))),e.ok(u))}))}t.validateTuple=a,t.default=o},1119:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(412),o=n(4783),a={keyword:"items",type:"array",schemaType:["object","boolean"],before:"uniqueItems",error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{schema:t,parentSchema:n,it:s}=e,{prefixItems:a}=n;s.items=!0,(0,r.alwaysValidSchema)(s,t)||(a?(0,o.validateAdditionalItems)(e,a):e.ok((0,i.validateArray)(e)))}};t.default=a},2182:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:"not",schemaType:["object","boolean"],trackErrors:!0,code(e){const{gen:t,schema:n,it:r}=e;if((0,s.alwaysValidSchema)(r,n))return void e.fail();const i=t.name("valid");e.subschema({keyword:"not",compositeRule:!0,createErrors:!1,allErrors:!1},i),e.failResult(i,(()=>e.reset()),(()=>e.error()))},error:{message:"must NOT be valid"}};t.default=r},4200:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"oneOf",schemaType:"array",trackErrors:!0,error:{message:"must match exactly one schema in oneOf",params:({params:e})=>s._`{passingSchemas: ${e.passing}}`},code(e){const{gen:t,schema:n,parentSchema:i,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(o.opts.discriminator&&i.discriminator)return;const a=n,l=t.let("valid",!1),c=t.let("passing",null),u=t.name("_valid");e.setParams({passing:c}),t.block((function(){a.forEach(((n,i)=>{let a;(0,r.alwaysValidSchema)(o,n)?t.var(u,!0):a=e.subschema({keyword:"oneOf",schemaProp:i,compositeRule:!0},u),i>0&&t.if(s._`${u} && ${l}`).assign(l,!1).assign(c,s._`[${c}, ${i}]`).else(),t.if(u,(()=>{t.assign(l,!0),t.assign(c,i),a&&e.mergeEvaluated(a,s.Name)}))}))})),e.result(l,(()=>e.reset()),(()=>e.error(!0)))}};t.default=i},2296:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(6776),o=n(6776),a={keyword:"patternProperties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,data:a,parentSchema:l,it:c}=e,{opts:u}=c,h=(0,s.allSchemaProperties)(n),d=h.filter((e=>(0,i.alwaysValidSchema)(c,n[e])));if(0===h.length||d.length===h.length&&(!c.opts.unevaluated||!0===c.props))return;const m=u.strictSchema&&!u.allowMatchingProperties&&l.properties,p=t.name("valid");!0===c.props||c.props instanceof r.Name||(c.props=(0,o.evaluatedPropsToName)(t,c.props));const{props:f}=c;function g(e){for(const t in m)new RegExp(e).test(t)&&(0,i.checkStrictMode)(c,`property ${t} matches pattern ${e} (use allowMatchingProperties)`)}function y(n){t.forIn("key",a,(i=>{t.if(r._`${(0,s.usePattern)(e,n)}.test(${i})`,(()=>{const s=d.includes(n);s||e.subschema({keyword:"patternProperties",schemaProp:n,dataProp:i,dataPropType:o.Type.Str},p),c.opts.unevaluated&&!0!==f?t.assign(r._`${f}[${i}]`,!0):s||c.allErrors||t.if((0,r.not)(p),(()=>t.break()))}))}))}!function(){for(const e of h)m&&g(e),c.allErrors?y(e):(t.var(p,!0),y(e),t.if(p))}()}};t.default=a},2924:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4665),r={keyword:"prefixItems",type:"array",schemaType:["array"],before:"uniqueItems",code:e=>(0,s.validateTuple)(e,"items")};t.default=r},6239:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(4815),r=n(412),i=n(6776),o=n(9351),a={keyword:"properties",type:"object",schemaType:"object",code(e){const{gen:t,schema:n,parentSchema:a,data:l,it:c}=e;"all"===c.opts.removeAdditional&&void 0===a.additionalProperties&&o.default.code(new s.KeywordCxt(c,o.default,"additionalProperties"));const u=(0,r.allSchemaProperties)(n);for(const e of u)c.definedProperties.add(e);c.opts.unevaluated&&u.length&&!0!==c.props&&(c.props=i.mergeEvaluated.props(t,(0,i.toHash)(u),c.props));const h=u.filter((e=>!(0,i.alwaysValidSchema)(c,n[e])));if(0===h.length)return;const d=t.name("valid");for(const n of h)m(n)?p(n):(t.if((0,r.propertyInData)(t,l,n,c.opts.ownProperties)),p(n),c.allErrors||t.else().var(d,!0),t.endIf()),e.it.definedProperties.add(n),e.ok(d);function m(e){return c.opts.useDefaults&&!c.compositeRule&&void 0!==n[e].default}function p(t){e.subschema({keyword:"properties",schemaProp:t,dataProp:t},d)}}};t.default=a},3708:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"propertyNames",type:"object",schemaType:["object","boolean"],error:{message:"property name must be valid",params:({params:e})=>s._`{propertyName: ${e.propertyName}}`},code(e){const{gen:t,schema:n,data:i,it:o}=e;if((0,r.alwaysValidSchema)(o,n))return;const a=t.name("valid");t.forIn("key",i,(n=>{e.setParams({propertyName:n}),e.subschema({keyword:"propertyNames",data:n,dataTypes:["string"],propertyName:n,compositeRule:!0},a),t.if((0,s.not)(a),(()=>{e.error(!0),o.allErrors||t.break()}))})),e.ok(a)}};t.default=i},6552:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:["then","else"],schemaType:["object","boolean"],code({keyword:e,parentSchema:t,it:n}){void 0===t.if&&(0,s.checkStrictMode)(n,`"${e}" without "if" is ignored`)}};t.default=r},412:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateUnion=t.validateArray=t.usePattern=t.callValidateCode=t.schemaProperties=t.allSchemaProperties=t.noPropertyInData=t.propertyInData=t.isOwnProperty=t.hasPropFunc=t.reportMissingProp=t.checkMissingProp=t.checkReportMissingProp=void 0;const s=n(3487),r=n(6776),i=n(2141),o=n(6776);function a(e){return e.scopeValue("func",{ref:Object.prototype.hasOwnProperty,code:s._`Object.prototype.hasOwnProperty`})}function l(e,t,n){return s._`${a(e)}.call(${t}, ${n})`}function c(e,t,n,r){const i=s._`${t}${(0,s.getProperty)(n)} === undefined`;return r?(0,s.or)(i,(0,s.not)(l(e,t,n))):i}function u(e){return e?Object.keys(e).filter((e=>"__proto__"!==e)):[]}t.checkReportMissingProp=function(e,t){const{gen:n,data:r,it:i}=e;n.if(c(n,r,t,i.opts.ownProperties),(()=>{e.setParams({missingProperty:s._`${t}`},!0),e.error()}))},t.checkMissingProp=function({gen:e,data:t,it:{opts:n}},r,i){return(0,s.or)(...r.map((r=>(0,s.and)(c(e,t,r,n.ownProperties),s._`${i} = ${r}`))))},t.reportMissingProp=function(e,t){e.setParams({missingProperty:t},!0),e.error()},t.hasPropFunc=a,t.isOwnProperty=l,t.propertyInData=function(e,t,n,r){const i=s._`${t}${(0,s.getProperty)(n)} !== undefined`;return r?s._`${i} && ${l(e,t,n)}`:i},t.noPropertyInData=c,t.allSchemaProperties=u,t.schemaProperties=function(e,t){return u(t).filter((n=>!(0,r.alwaysValidSchema)(e,t[n])))},t.callValidateCode=function({schemaCode:e,data:t,it:{gen:n,topSchemaRef:r,schemaPath:o,errorPath:a},it:l},c,u,h){const d=h?s._`${e}, ${t}, ${r}${o}`:t,m=[[i.default.instancePath,(0,s.strConcat)(i.default.instancePath,a)],[i.default.parentData,l.parentData],[i.default.parentDataProperty,l.parentDataProperty],[i.default.rootData,i.default.rootData]];l.opts.dynamicRef&&m.push([i.default.dynamicAnchors,i.default.dynamicAnchors]);const p=s._`${d}, ${n.object(...m)}`;return u!==s.nil?s._`${c}.call(${u}, ${p})`:s._`${c}(${p})`};const h=s._`new RegExp`;t.usePattern=function({gen:e,it:{opts:t}},n){const r=t.unicodeRegExp?"u":"",{regExp:i}=t.code,a=i(n,r);return e.scopeValue("pattern",{key:a.toString(),ref:a,code:s._`${"new RegExp"===i.code?h:(0,o.useFunc)(e,i)}(${n}, ${r})`})},t.validateArray=function(e){const{gen:t,data:n,keyword:i,it:o}=e,a=t.name("valid");if(o.allErrors){const e=t.let("valid",!0);return l((()=>t.assign(e,!1))),e}return t.var(a,!0),l((()=>t.break())),a;function l(o){const l=t.const("len",s._`${n}.length`);t.forRange("i",0,l,(n=>{e.subschema({keyword:i,dataProp:n,dataPropType:r.Type.Num},a),t.if((0,s.not)(a),o)}))}},t.validateUnion=function(e){const{gen:t,schema:n,keyword:i,it:o}=e;if(!Array.isArray(n))throw new Error("ajv implementation error");if(n.some((e=>(0,r.alwaysValidSchema)(o,e)))&&!o.opts.unevaluated)return;const a=t.let("valid",!1),l=t.name("_valid");t.block((()=>n.forEach(((n,r)=>{const o=e.subschema({keyword:i,schemaProp:r,compositeRule:!0},l);t.assign(a,s._`${a} || ${l}`),e.mergeValidEvaluated(o,l)||t.if((0,s.not)(a))})))),e.result(a,(()=>e.reset()),(()=>e.error(!0)))}},8386:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"id",code(){throw new Error('NOT SUPPORTED: keyword "id", use "$id" for schema ID')}};t.default=n},5684:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(8386),r=n(8280),i=["$schema","$id","$defs","$vocabulary",{keyword:"$comment"},"definitions",s.default,r.default];t.default=i},8280:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.callRef=t.getValidate=void 0;const s=n(6646),r=n(412),i=n(3487),o=n(2141),a=n(5173),l=n(6776),c={keyword:"$ref",schemaType:"string",code(e){const{gen:t,schema:n,it:r}=e,{baseId:o,schemaEnv:l,validateName:c,opts:d,self:m}=r,{root:p}=l;if(("#"===n||"#/"===n)&&o===p.baseId)return function(){if(l===p)return h(e,c,l,l.$async);const n=t.scopeValue("root",{ref:p});return h(e,i._`${n}.validate`,p,p.$async)}();const f=a.resolveRef.call(m,p,o,n);if(void 0===f)throw new s.default(r.opts.uriResolver,o,n);return f instanceof a.SchemaEnv?function(t){const n=u(e,t);h(e,n,t,t.$async)}(f):function(s){const r=t.scopeValue("schema",!0===d.code.source?{ref:s,code:(0,i.stringify)(s)}:{ref:s}),o=t.name("valid"),a=e.subschema({schema:s,dataTypes:[],schemaPath:i.nil,topSchemaRef:r,errSchemaPath:n},o);e.mergeEvaluated(a),e.ok(o)}(f)}};function u(e,t){const{gen:n}=e;return t.validate?n.scopeValue("validate",{ref:t.validate}):i._`${n.scopeValue("wrapper",{ref:t})}.validate`}function h(e,t,n,s){const{gen:a,it:c}=e,{allErrors:u,schemaEnv:h,opts:d}=c,m=d.passContext?o.default.this:i.nil;function p(e){const t=i._`${e}.errors`;a.assign(o.default.vErrors,i._`${o.default.vErrors} === null ? ${t} : ${o.default.vErrors}.concat(${t})`),a.assign(o.default.errors,i._`${o.default.vErrors}.length`)}function f(e){var t;if(!c.opts.unevaluated)return;const s=null===(t=null==n?void 0:n.validate)||void 0===t?void 0:t.evaluated;if(!0!==c.props)if(s&&!s.dynamicProps)void 0!==s.props&&(c.props=l.mergeEvaluated.props(a,s.props,c.props));else{const t=a.var("props",i._`${e}.evaluated.props`);c.props=l.mergeEvaluated.props(a,t,c.props,i.Name)}if(!0!==c.items)if(s&&!s.dynamicItems)void 0!==s.items&&(c.items=l.mergeEvaluated.items(a,s.items,c.items));else{const t=a.var("items",i._`${e}.evaluated.items`);c.items=l.mergeEvaluated.items(a,t,c.items,i.Name)}}s?function(){if(!h.$async)throw new Error("async schema referenced by sync schema");const n=a.let("valid");a.try((()=>{a.code(i._`await ${(0,r.callValidateCode)(e,t,m)}`),f(t),u||a.assign(n,!0)}),(e=>{a.if(i._`!(${e} instanceof ${c.ValidationError})`,(()=>a.throw(e))),p(e),u||a.assign(n,!1)})),e.ok(n)}():e.result((0,r.callValidateCode)(e,t,m),(()=>f(t)),(()=>p(t)))}t.getValidate=u,t.callRef=h,t.default=c},1240:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(9306),i=n(5173),o=n(6776),a={keyword:"discriminator",type:"object",schemaType:"object",error:{message:({params:{discrError:e,tagName:t}})=>e===r.DiscrError.Tag?`tag "${t}" must be string`:`value of tag "${t}" must be in oneOf`,params:({params:{discrError:e,tag:t,tagName:n}})=>s._`{error: ${e}, tag: ${n}, tagValue: ${t}}`},code(e){const{gen:t,data:n,schema:a,parentSchema:l,it:c}=e,{oneOf:u}=l;if(!c.opts.discriminator)throw new Error("discriminator: requires discriminator option");const h=a.propertyName;if("string"!=typeof h)throw new Error("discriminator: requires propertyName");if(a.mapping)throw new Error("discriminator: mapping is not supported");if(!u)throw new Error("discriminator: requires oneOf keyword");const d=t.let("valid",!1),m=t.const("tag",s._`${n}${(0,s.getProperty)(h)}`);function p(n){const r=t.name("valid"),i=e.subschema({keyword:"oneOf",schemaProp:n},r);return e.mergeEvaluated(i,s.Name),r}t.if(s._`typeof ${m} == "string"`,(()=>function(){const n=function(){var e;const t={},n=r(l);let s=!0;for(let t=0;t<u.length;t++){let l=u[t];(null==l?void 0:l.$ref)&&!(0,o.schemaHasRulesButRef)(l,c.self.RULES)&&(l=i.resolveRef.call(c.self,c.schemaEnv.root,c.baseId,null==l?void 0:l.$ref),l instanceof i.SchemaEnv&&(l=l.schema));const d=null===(e=null==l?void 0:l.properties)||void 0===e?void 0:e[h];if("object"!=typeof d)throw new Error(`discriminator: oneOf subschemas (or referenced schemas) must have "properties/${h}"`);s=s&&(n||r(l)),a(d,t)}if(!s)throw new Error(`discriminator: "${h}" must be required`);return t;function r({required:e}){return Array.isArray(e)&&e.includes(h)}function a(e,t){if(e.const)d(e.const,t);else{if(!e.enum)throw new Error(`discriminator: "properties/${h}" must have "const" or "enum"`);for(const n of e.enum)d(n,t)}}function d(e,n){if("string"!=typeof e||e in t)throw new Error(`discriminator: "${h}" values must be unique strings`);t[e]=n}}();t.if(!1);for(const e in n)t.elseIf(s._`${m} === ${e}`),t.assign(d,p(n[e]));t.else(),e.error(!1,{discrError:r.DiscrError.Mapping,tag:m,tagName:h}),t.endIf()}()),(()=>e.error(!1,{discrError:r.DiscrError.Tag,tag:m,tagName:h}))),e.ok(d)}};t.default=a},9306:(e,t)=>{"use strict";var n;Object.defineProperty(t,"__esModule",{value:!0}),t.DiscrError=void 0,(n=t.DiscrError||(t.DiscrError={})).Tag="tag",n.Mapping="mapping"},7299:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(5684),r=n(2649),i=n(8200),o=n(6121),a=n(1448),l=n(808),c=n(9502),u=n(6167),h=[o.default,s.default,r.default,(0,i.default)(!0),c.default,u.metadataVocabulary,u.contentVocabulary,a.default,l.default];t.default=h},3924:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(5684),r=n(2649),i=n(8200),o=n(9502),a=n(6167),l=[s.default,r.default,(0,i.default)(),o.default,a.metadataVocabulary,a.contentVocabulary];t.default=l},6215:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicAnchor=void 0;const s=n(3487),r=n(2141),i=n(5173),o=n(8280),a={keyword:"$dynamicAnchor",schemaType:"string",code:e=>l(e,e.schema)};function l(e,t){const{gen:n,it:a}=e;a.schemaEnv.root.dynamicAnchors[t]=!0;const l=s._`${r.default.dynamicAnchors}${(0,s.getProperty)(t)}`,c="#"===a.errSchemaPath?a.validateName:function(e){const{schemaEnv:t,schema:n,self:s}=e.it,{root:r,baseId:a,localRefs:l,meta:c}=t.root,{schemaId:u}=s.opts,h=new i.SchemaEnv({schema:n,schemaId:u,root:r,baseId:a,localRefs:l,meta:c});return i.compileSchema.call(s,h),(0,o.getValidate)(e,h)}(e);n.if(s._`!${l}`,(()=>n.assign(l,c)))}t.dynamicAnchor=l,t.default=a},1919:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.dynamicRef=void 0;const s=n(3487),r=n(2141),i=n(8280),o={keyword:"$dynamicRef",schemaType:"string",code:e=>a(e,e.schema)};function a(e,t){const{gen:n,keyword:o,it:a}=e;if("#"!==t[0])throw new Error(`"${o}" only supports hash fragment reference`);const l=t.slice(1);if(a.allErrors)c();else{const t=n.let("valid",!1);c(t),e.ok(t)}function c(e){if(a.schemaEnv.root.dynamicAnchors[l]){const t=n.let("_v",s._`${r.default.dynamicAnchors}${(0,s.getProperty)(l)}`);n.if(t,u(t,e),u(a.validateName,e))}else u(a.validateName,e)()}function u(t,s){return s?()=>n.block((()=>{(0,i.callRef)(e,t),n.let(s,!0)})):()=>(0,i.callRef)(e,t)}}t.dynamicRef=a,t.default=o},6121:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6215),r=n(1919),i=n(4094),o=n(3944),a=[s.default,r.default,i.default,o.default];t.default=a},4094:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6215),r=n(6776),i={keyword:"$recursiveAnchor",schemaType:"boolean",code(e){e.schema?(0,s.dynamicAnchor)(e,""):(0,r.checkStrictMode)(e.it,"$recursiveAnchor: false is ignored")}};t.default=i},3944:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1919),r={keyword:"$recursiveRef",schemaType:"string",code:e=>(0,s.dynamicRef)(e,e.schema)};t.default=r},9651:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:"format",type:["number","string"],schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>s.str`must match format "${e}"`,params:({schemaCode:e})=>s._`{format: ${e}}`},code(e,t){const{gen:n,data:r,$data:i,schema:o,schemaCode:a,it:l}=e,{opts:c,errSchemaPath:u,schemaEnv:h,self:d}=l;c.validateFormats&&(i?function(){const i=n.scopeValue("formats",{ref:d.formats,code:c.code.formats}),o=n.const("fDef",s._`${i}[${a}]`),l=n.let("fType"),u=n.let("format");n.if(s._`typeof ${o} == "object" && !(${o} instanceof RegExp)`,(()=>n.assign(l,s._`${o}.type || "string"`).assign(u,s._`${o}.validate`)),(()=>n.assign(l,s._`"string"`).assign(u,o))),e.fail$data((0,s.or)(!1===c.strictSchema?s.nil:s._`${a} && !${u}`,function(){const e=h.$async?s._`(${o}.async ? await ${u}(${r}) : ${u}(${r}))`:s._`${u}(${r})`,n=s._`(typeof ${u} == "function" ? ${e} : ${u}.test(${r}))`;return s._`${u} && ${u} !== true && ${l} === ${t} && !${n}`}()))}():function(){const i=d.formats[o];if(!i)return void function(){if(!1!==c.strictSchema)throw new Error(e());function e(){return`unknown format "${o}" ignored in schema at path "${u}"`}d.logger.warn(e())}();if(!0===i)return;const[a,l,m]=function(e){const t=e instanceof RegExp?(0,s.regexpCode)(e):c.code.formats?s._`${c.code.formats}${(0,s.getProperty)(o)}`:void 0,r=n.scopeValue("formats",{key:o,ref:e,code:t});return"object"!=typeof e||e instanceof RegExp?["string",e,r]:[e.type||"string",e.validate,s._`${r}.validate`]}(i);a===t&&e.pass(function(){if("object"==typeof i&&!(i instanceof RegExp)&&i.async){if(!h.$async)throw new Error("async format in sync schema");return s._`await ${m}(${r})`}return"function"==typeof l?s._`${m}(${r})`:s._`${m}.test(${r})`}())}())}};t.default=r},9502:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=[n(9651).default];t.default=s},6167:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.contentVocabulary=t.metadataVocabulary=void 0,t.metadataVocabulary=["title","description","default","deprecated","readOnly","writeOnly","examples"],t.contentVocabulary=["contentMediaType","contentEncoding","contentSchema"]},1448:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(8921),r=n(7274),i=n(3633),o=[s.default,r.default,i.default];t.default=o},808:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(1782),r=n(4641),i=[s.default,r.default];t.default=i},4641:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i={keyword:"unevaluatedItems",type:"array",schemaType:["boolean","object"],error:{message:({params:{len:e}})=>s.str`must NOT have more than ${e} items`,params:({params:{len:e}})=>s._`{limit: ${e}}`},code(e){const{gen:t,schema:n,data:i,it:o}=e,a=o.items||0;if(!0===a)return;const l=t.const("len",s._`${i}.length`);if(!1===n)e.setParams({len:a}),e.fail(s._`${l} > ${a}`);else if("object"==typeof n&&!(0,r.alwaysValidSchema)(o,n)){const n=t.var("valid",s._`${l} <= ${a}`);t.if((0,s.not)(n),(()=>function(n,i){t.forRange("i",i,l,(i=>{e.subschema({keyword:"unevaluatedItems",dataProp:i,dataPropType:r.Type.Num},n),o.allErrors||t.if((0,s.not)(n),(()=>t.break()))}))}(n,a))),e.ok(n)}o.items=!0}};t.default=i},1782:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(2141),o={keyword:"unevaluatedProperties",type:"object",schemaType:["boolean","object"],trackErrors:!0,error:{message:"must NOT have unevaluated properties",params:({params:e})=>s._`{unevaluatedProperty: ${e.unevaluatedProperty}}`},code(e){const{gen:t,schema:n,data:o,errsCount:a,it:l}=e;if(!a)throw new Error("ajv implementation error");const{allErrors:c,props:u}=l;function h(i){if(!1===n)return e.setParams({unevaluatedProperty:i}),e.error(),void(c||t.break());if(!(0,r.alwaysValidSchema)(l,n)){const n=t.name("valid");e.subschema({keyword:"unevaluatedProperties",dataProp:i,dataPropType:r.Type.Str},n),c||t.if((0,s.not)(n),(()=>t.break()))}}u instanceof s.Name?t.if(s._`${u} !== true`,(()=>t.forIn("key",o,(e=>t.if(function(e,t){return s._`!${e} || !${e}[${t}]`}(u,e),(()=>h(e))))))):!0!==u&&t.forIn("key",o,(e=>void 0===u?h(e):t.if(function(e,t){const n=[];for(const r in e)!0===e[r]&&n.push(s._`${t} !== ${r}`);return(0,s.and)(...n)}(u,e),(()=>h(e))))),l.props=!0,e.ok(s._`${a} === ${i.default.errors}`)}};t.default=o},4693:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(3510),o={keyword:"const",$data:!0,error:{message:"must be equal to constant",params:({schemaCode:e})=>s._`{allowedValue: ${e}}`},code(e){const{gen:t,data:n,$data:o,schemaCode:a,schema:l}=e;o||l&&"object"==typeof l?e.fail$data(s._`!${(0,r.useFunc)(t,i.default)}(${n}, ${a})`):e.fail(s._`${l} !== ${n}`)}};t.default=o},8921:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(7772),r={keyword:"dependentRequired",type:"object",schemaType:"object",error:s.error,code:e=>(0,s.validatePropertyDeps)(e)};t.default=r},966:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(3510),o={keyword:"enum",schemaType:"array",$data:!0,error:{message:"must be equal to one of the allowed values",params:({schemaCode:e})=>s._`{allowedValues: ${e}}`},code(e){const{gen:t,data:n,$data:o,schema:a,schemaCode:l,it:c}=e;if(!o&&0===a.length)throw new Error("enum must have non-empty array");const u=a.length>=c.opts.loopEnum;let h;const d=()=>null!=h?h:h=(0,r.useFunc)(t,i.default);let m;if(u||o)m=t.let("valid"),e.block$data(m,(function(){t.assign(m,!1),t.forOf("v",l,(e=>t.if(s._`${d()}(${n}, ${e})`,(()=>t.assign(m,!0).break()))))}));else{if(!Array.isArray(a))throw new Error("ajv implementation error");const e=t.const("vSchema",l);m=(0,s.or)(...a.map(((t,r)=>function(e,t){const r=a[t];return"object"==typeof r&&null!==r?s._`${d()}(${n}, ${e}[${t}])`:s._`${n} === ${r}`}(e,r))))}e.pass(m)}};t.default=o},2649:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3983),r=n(430),i=n(3229),o=n(4336),a=n(498),l=n(3301),c=n(1687),u=n(2958),h=n(4693),d=n(966),m=[s.default,r.default,i.default,o.default,a.default,l.default,c.default,u.default,{keyword:"type",schemaType:["string","array"]},{keyword:"nullable",schemaType:"boolean"},h.default,d.default];t.default=m},3633:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(6776),r={keyword:["maxContains","minContains"],type:"array",schemaType:"number",code({keyword:e,parentSchema:t,it:n}){void 0===t.contains&&(0,s.checkStrictMode)(n,`"${e}" without "contains" is ignored`)}};t.default=r},1687:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:["maxItems","minItems"],type:"array",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxItems"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} items`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,i="maxItems"===t?s.operators.GT:s.operators.LT;e.fail$data(s._`${n}.length ${i} ${r}`)}};t.default=r},3229:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=n(6776),i=n(4499),o={keyword:["maxLength","minLength"],type:"string",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxLength"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} characters`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:o,it:a}=e,l="maxLength"===t?s.operators.GT:s.operators.LT,c=!1===a.opts.unicode?s._`${n}.length`:s._`${(0,r.useFunc)(e.gen,i.default)}(${n})`;e.fail$data(s._`${c} ${l} ${o}`)}};t.default=o},3983:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r=s.operators,i={maximum:{okStr:"<=",ok:r.LTE,fail:r.GT},minimum:{okStr:">=",ok:r.GTE,fail:r.LT},exclusiveMaximum:{okStr:"<",ok:r.LT,fail:r.GTE},exclusiveMinimum:{okStr:">",ok:r.GT,fail:r.LTE}},o={message:({keyword:e,schemaCode:t})=>s.str`must be ${i[e].okStr} ${t}`,params:({keyword:e,schemaCode:t})=>s._`{comparison: ${i[e].okStr}, limit: ${t}}`},a={keyword:Object.keys(i),type:"number",schemaType:"number",$data:!0,error:o,code(e){const{keyword:t,data:n,schemaCode:r}=e;e.fail$data(s._`${n} ${i[t].fail} ${r} || isNaN(${n})`)}};t.default=a},498:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:["maxProperties","minProperties"],type:"object",schemaType:"number",$data:!0,error:{message({keyword:e,schemaCode:t}){const n="maxProperties"===e?"more":"fewer";return s.str`must NOT have ${n} than ${t} properties`},params:({schemaCode:e})=>s._`{limit: ${e}}`},code(e){const{keyword:t,data:n,schemaCode:r}=e,i="maxProperties"===t?s.operators.GT:s.operators.LT;e.fail$data(s._`Object.keys(${n}).length ${i} ${r}`)}};t.default=r},430:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(3487),r={keyword:"multipleOf",type:"number",schemaType:"number",$data:!0,error:{message:({schemaCode:e})=>s.str`must be multiple of ${e}`,params:({schemaCode:e})=>s._`{multipleOf: ${e}}`},code(e){const{gen:t,data:n,schemaCode:r,it:i}=e,o=i.opts.multipleOfPrecision,a=t.let("res"),l=o?s._`Math.abs(Math.round(${a}) - ${a}) > 1e-${o}`:s._`${a} !== parseInt(${a})`;e.fail$data(s._`(${r} === 0 || (${a} = ${n}/${r}, ${l}))`)}};t.default=r},4336:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i={keyword:"pattern",type:"string",schemaType:"string",$data:!0,error:{message:({schemaCode:e})=>r.str`must match pattern "${e}"`,params:({schemaCode:e})=>r._`{pattern: ${e}}`},code(e){const{data:t,$data:n,schema:i,schemaCode:o,it:a}=e,l=a.opts.unicodeRegExp?"u":"",c=n?r._`(new RegExp(${o}, ${l}))`:(0,s.usePattern)(e,i);e.fail$data(r._`!${c}.test(${t})`)}};t.default=i},3301:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(412),r=n(3487),i=n(6776),o={keyword:"required",type:"object",schemaType:"array",$data:!0,error:{message:({params:{missingProperty:e}})=>r.str`must have required property '${e}'`,params:({params:{missingProperty:e}})=>r._`{missingProperty: ${e}}`},code(e){const{gen:t,schema:n,schemaCode:o,data:a,$data:l,it:c}=e,{opts:u}=c;if(!l&&0===n.length)return;const h=n.length>=u.loopRequired;if(c.allErrors?function(){if(h||l)e.block$data(r.nil,d);else for(const t of n)(0,s.checkReportMissingProp)(e,t)}():function(){const i=t.let("missing");if(h||l){const n=t.let("valid",!0);e.block$data(n,(()=>function(n,i){e.setParams({missingProperty:n}),t.forOf(n,o,(()=>{t.assign(i,(0,s.propertyInData)(t,a,n,u.ownProperties)),t.if((0,r.not)(i),(()=>{e.error(),t.break()}))}),r.nil)}(i,n))),e.ok(n)}else t.if((0,s.checkMissingProp)(e,n,i)),(0,s.reportMissingProp)(e,i),t.else()}(),u.strictRequired){const t=e.parentSchema.properties,{definedProperties:s}=e.it;for(const e of n)if(void 0===(null==t?void 0:t[e])&&!s.has(e)){const t=`required property "${e}" is not defined at "${c.schemaEnv.baseId+c.errSchemaPath}" (strictRequired)`;(0,i.checkStrictMode)(c,t,c.opts.strictRequired)}}function d(){t.forOf("prop",o,(n=>{e.setParams({missingProperty:n}),t.if((0,s.noPropertyInData)(t,a,n,u.ownProperties),(()=>e.error()))}))}}};t.default=o},2958:(e,t,n)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const s=n(453),r=n(3487),i=n(6776),o=n(3510),a={keyword:"uniqueItems",type:"array",schemaType:"boolean",$data:!0,error:{message:({params:{i:e,j:t}})=>r.str`must NOT have duplicate items (items ## ${t} and ${e} are identical)`,params:({params:{i:e,j:t}})=>r._`{i: ${e}, j: ${t}}`},code(e){const{gen:t,data:n,$data:a,schema:l,parentSchema:c,schemaCode:u,it:h}=e;if(!a&&!l)return;const d=t.let("valid"),m=c.items?(0,s.getSchemaTypes)(c.items):[];function p(i,o){const a=t.name("item"),l=(0,s.checkDataTypes)(m,a,h.opts.strictNumbers,s.DataType.Wrong),c=t.const("indices",r._`{}`);t.for(r._`;${i}--;`,(()=>{t.let(a,r._`${n}[${i}]`),t.if(l,r._`continue`),m.length>1&&t.if(r._`typeof ${a} == "string"`,r._`${a} += "_"`),t.if(r._`typeof ${c}[${a}] == "number"`,(()=>{t.assign(o,r._`${c}[${a}]`),e.error(),t.assign(d,!1).break()})).code(r._`${c}[${a}] = ${i}`)}))}function f(s,a){const l=(0,i.useFunc)(t,o.default),c=t.name("outer");t.label(c).for(r._`;${s}--;`,(()=>t.for(r._`${a} = ${s}; ${a}--;`,(()=>t.if(r._`${l}(${n}[${s}], ${n}[${a}])`,(()=>{e.error(),t.assign(d,!1).break(c)}))))))}e.block$data(d,(function(){const s=t.let("i",r._`${n}.length`),i=t.let("j");e.setParams({i:s,j:i}),t.assign(d,!0),t.if(r._`${s} > 1`,(()=>(m.length>0&&!m.some((e=>"object"===e||"array"===e))?p:f)(s,i)))}),r._`${u} === false`),e.ok(d)}};t.default=a},8277:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,"\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}","",{version:3,sources:["webpack://./css/cell-renderer.css"],names:[],mappings:";AACA;IACI,8CAA8C;AAClD;;AAEA;IACI,eAAe;AACnB",sourcesContent:["\n.ui-form.ui-tooltip .ui-input-root > label.ui-input-label:not(:empty) {\n /* min-width: 30px; /* Breaks right margin /**/\n}\n\n.ui-form.ui-tooltip .ui-input-root > div.ui-input-text:not(:empty) {\n margin-top: 6px;\n}"],sourceRoot:""}]);const a=o},5362:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}","",{version:3,sources:["webpack://./css/composition-analysis.css"],names:[],mappings:"AAAA;IACI,iBAAiB;IACjB,kBAAkB;AACtB;;AAEA;IACI,eAAe;IACf,cAAc;IACd,iBAAiB;IACjB,oBAAoB;IACpB,iBAAiB;AACrB;;AAEA;IACI,aAAa;AACjB",sourcesContent:[".macromolecule-cell-comp-analysis-host{\n max-height: 250px;\n overflow-y: scroll;\n}\n\n.macromolecule-cell-comp-analysis-bar{\n height: inherit;\n display: block;\n margin-top: 1.5px;\n margin-bottom: 1.5px;\n margin-right: 3px;\n}\n\n.macromolecule-cell-comp-analysis-value{\n display: flex;\n}"],sourceRoot:""}]);const a=o},9564:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}","",{version:3,sources:["webpack://./css/msa.css"],names:[],mappings:"AAAA;IACI,gBAAgB;IAChB,eAAe;IACf,eAAe;IACf,YAAY;AAChB;AACA;IACI,oBAAoB;AACxB",sourcesContent:[".kalign-version {\n margin-bottom: 0;\n text-align: end;\n font-size: 12px;\n opacity: 0.8;\n}\nbutton.msa-params-button.ui-btn {\n justify-content: end;\n}"],sourceRoot:""}]);const a=o},9414:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}","",{version:3,sources:["webpack://./node_modules/@datagrok-libraries/ml/css/styles.css"],names:[],mappings:"AAAA;IACI,4BAA4B;IAC5B,WAAW;AACf;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,SAAS;AACb;;AAEA;IACI,eAAe;IACf,kBAAkB;IAClB,YAAY;;AAEhB;;AAEA;IACI,WAAW;AACf;AACA;IACI,gBAAgB;AACpB;;AAEA;IACI,wBAAwB;AAC5B;;AAEA;IACI,iBAAiB;AACrB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,oBAAoB;AACxB;;AAEA;IACI,aAAa;IACb,mBAAmB;IACnB,mBAAmB;IACnB,8BAA8B;IAC9B,uBAAuB;AAC3B;;AAEA;IACI,uBAAuB;IACvB,gBAAgB;AACpB;;AAEA;IACI,4BAA4B;AAChC;;AAEA;IACI,kBAAkB;AACtB",sourcesContent:[".scatter_plot_link {\n position: absolute!important;\n right: 10px;\n}\n\n.cliffs_grid {\n top: 10px;\n}\n\n.show_only_cliffs {\n top: 30px;\n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings {\n font-size: 18px;\n position: absolute;\n height: 28px;\n \n}\n\n.ml-dim-reduction-settings-input i.grok-icon.grok-font-icon-settings:not(.ml-dim-reduction-column-editor-input-root i) {\n left: -20px;\n}\n.dlg-dimensionality-reduction.ui-form, .dlg-markov-clustering.ui-form, .dlg-markov-clustering.ui-form .ui-form, .dlg-dimensionality-reduction.ui-form .ui-form {\n max-width: unset;\n}\n\n.ml-dim-reduction-column-editor-input-root label {\n display: none !important;\n}\n\n.dim-reduction-dialog-form > .ui-input-root, .dim-reduction-dialog-form > div > .ui-input-root {\n margin-left: 10px;\n}\n\n.ml-dim-reduction-column-editor-input-root input, .ml-dim-reduction-column-editor-input-root select {\n margin-left: 20px !important;\n}\n\nh3.ml-dim-reduction-column-editor-input-root {\n margin: 0 !important;\n}\n\n.ml-dim-reduction-column-editor-root, .ml-dim-reduction-column-editor-header-root {\n display: flex;\n flex-direction: row;\n align-items: center;\n margin-bottom: 10px !important;\n width: 700px !important;\n}\n\n.ml-dim-reduction-column-editor-column-title {\n text-overflow: ellipsis;\n overflow: hidden;\n}\n\n.ml-dim-reduction-column-editor-header-root > h1:not(:first-child) {\n margin-left: 20px !important;\n}\n\n.ml-dim-reduction-column-editor-table-root .header > td:not(:first-child) {\n padding-left: 32px;\n}"],sourceRoot:""}]);const a=o},8710:(e,t,n)=>{"use strict";n.d(t,{Z:()=>a});var s=n(7537),r=n.n(s),i=n(3645),o=n.n(i)()(r());o.push([e.id,".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n","",{version:3,sources:["webpack://./src/utils/monomer-lib/library-file-manager/style.css"],names:[],mappings:"AAAA;EACE,iBAAiB;EACjB,kBAAkB;EAClB,aAAa;EACb,sBAAsB;EACtB,mBAAmB;EACnB,WAAW;AACb",sourcesContent:[".monomer-lib-controls-form {\n margin-left: auto;\n margin-right: auto;\n display: flex;\n flex-direction: column;\n align-items: center;\n width: 100%;\n}\n"],sourceRoot:""}]);const a=o},3645:e=>{"use strict";e.exports=function(e){var t=[];return t.toString=function(){return this.map((function(t){var n="",s=void 0!==t[5];return t[4]&&(n+="@supports (".concat(t[4],") {")),t[2]&&(n+="@media ".concat(t[2]," {")),s&&(n+="@layer".concat(t[5].length>0?" ".concat(t[5]):""," {")),n+=e(t),s&&(n+="}"),t[2]&&(n+="}"),t[4]&&(n+="}"),n})).join("")},t.i=function(e,n,s,r,i){"string"==typeof e&&(e=[[null,e,void 0]]);var o={};if(s)for(var a=0;a<this.length;a++){var l=this[a][0];null!=l&&(o[l]=!0)}for(var c=0;c<e.length;c++){var u=[].concat(e[c]);s&&o[u[0]]||(void 0!==i&&(void 0===u[5]||(u[1]="@layer".concat(u[5].length>0?" ".concat(u[5]):""," {").concat(u[1],"}")),u[5]=i),n&&(u[2]?(u[1]="@media ".concat(u[2]," {").concat(u[1],"}"),u[2]=n):u[2]=n),r&&(u[4]?(u[1]="@supports (".concat(u[4],") {").concat(u[1],"}"),u[4]=r):u[4]="".concat(r)),t.push(u))}},t}},7537:e=>{"use strict";e.exports=function(e){var t=e[1],n=e[3];if(!n)return t;if("function"==typeof btoa){var s=btoa(unescape(encodeURIComponent(JSON.stringify(n)))),r="sourceMappingURL=data:application/json;charset=utf-8;base64,".concat(s),i="/*# ".concat(r," */");return[t].concat([i]).join("\n")}return[t].join("\n")}},4063:e=>{"use strict";e.exports=function e(t,n){if(t===n)return!0;if(t&&n&&"object"==typeof t&&"object"==typeof n){if(t.constructor!==n.constructor)return!1;var s,r,i;if(Array.isArray(t)){if((s=t.length)!=n.length)return!1;for(r=s;0!=r--;)if(!e(t[r],n[r]))return!1;return!0}if(t.constructor===RegExp)return t.source===n.source&&t.flags===n.flags;if(t.valueOf!==Object.prototype.valueOf)return t.valueOf()===n.valueOf();if(t.toString!==Object.prototype.toString)return t.toString()===n.toString();if((s=(i=Object.keys(t)).length)!==Object.keys(n).length)return!1;for(r=s;0!=r--;)if(!Object.prototype.hasOwnProperty.call(n,i[r]))return!1;for(r=s;0!=r--;){var o=i[r];if(!e(t[o],n[o]))return!1}return!0}return t!=t&&n!=n}},9133:function(e,t,n){var s;!function(t,r){var i={};!function(e){"use strict";e.__esModule=!0,e.digestLength=32,e.blockSize=64;var t=new Uint32Array([1116352408,1899447441,3049323471,3921009573,961987163,1508970993,2453635748,2870763221,3624381080,310598401,607225278,1426881987,1925078388,2162078206,2614888103,3248222580,3835390401,4022224774,264347078,604807628,770255983,1249150122,1555081692,1996064986,2554220882,2821834349,2952996808,3210313671,3336571891,3584528711,113926993,338241895,666307205,773529912,1294757372,1396182291,1695183700,1986661051,2177026350,2456956037,2730485921,2820302411,3259730800,3345764771,3516065817,3600352804,4094571909,275423344,430227734,506948616,659060556,883997877,958139571,1322822218,1537002063,1747873779,1955562222,2024104815,2227730452,2361852424,2428436474,2756734187,3204031479,3329325298]);function n(e,n,s,r,i){for(var o,a,l,c,u,h,d,m,p,f,g,y,b;i>=64;){for(o=n[0],a=n[1],l=n[2],c=n[3],u=n[4],h=n[5],d=n[6],m=n[7],f=0;f<16;f++)g=r+4*f,e[f]=(255&s[g])<<24|(255&s[g+1])<<16|(255&s[g+2])<<8|255&s[g+3];for(f=16;f<64;f++)y=((p=e[f-2])>>>17|p<<15)^(p>>>19|p<<13)^p>>>10,b=((p=e[f-15])>>>7|p<<25)^(p>>>18|p<<14)^p>>>3,e[f]=(y+e[f-7]|0)+(b+e[f-16]|0);for(f=0;f<64;f++)y=(((u>>>6|u<<26)^(u>>>11|u<<21)^(u>>>25|u<<7))+(u&h^~u&d)|0)+(m+(t[f]+e[f]|0)|0)|0,b=((o>>>2|o<<30)^(o>>>13|o<<19)^(o>>>22|o<<10))+(o&a^o&l^a&l)|0,m=d,d=h,h=u,u=c+y|0,c=l,l=a,a=o,o=y+b|0;n[0]+=o,n[1]+=a,n[2]+=l,n[3]+=c,n[4]+=u,n[5]+=h,n[6]+=d,n[7]+=m,r+=64,i-=64}return r}var s=function(){function t(){this.digestLength=e.digestLength,this.blockSize=e.blockSize,this.state=new Int32Array(8),this.temp=new Int32Array(64),this.buffer=new Uint8Array(128),this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this.reset()}return t.prototype.reset=function(){return this.state[0]=1779033703,this.state[1]=3144134277,this.state[2]=1013904242,this.state[3]=2773480762,this.state[4]=1359893119,this.state[5]=2600822924,this.state[6]=528734635,this.state[7]=1541459225,this.bufferLength=0,this.bytesHashed=0,this.finished=!1,this},t.prototype.clean=function(){for(var e=0;e<this.buffer.length;e++)this.buffer[e]=0;for(e=0;e<this.temp.length;e++)this.temp[e]=0;this.reset()},t.prototype.update=function(e,t){if(void 0===t&&(t=e.length),this.finished)throw new Error("SHA256: can't update because hash was finished.");var s=0;if(this.bytesHashed+=t,this.bufferLength>0){for(;this.bufferLength<64&&t>0;)this.buffer[this.bufferLength++]=e[s++],t--;64===this.bufferLength&&(n(this.temp,this.state,this.buffer,0,64),this.bufferLength=0)}for(t>=64&&(s=n(this.temp,this.state,e,s,t),t%=64);t>0;)this.buffer[this.bufferLength++]=e[s++],t--;return this},t.prototype.finish=function(e){if(!this.finished){var t=this.bytesHashed,s=this.bufferLength,r=t/536870912|0,i=t<<3,o=t%64<56?64:128;this.buffer[s]=128;for(var a=s+1;a<o-8;a++)this.buffer[a]=0;this.buffer[o-8]=r>>>24&255,this.buffer[o-7]=r>>>16&255,this.buffer[o-6]=r>>>8&255,this.buffer[o-5]=r>>>0&255,this.buffer[o-4]=i>>>24&255,this.buffer[o-3]=i>>>16&255,this.buffer[o-2]=i>>>8&255,this.buffer[o-1]=i>>>0&255,n(this.temp,this.state,this.buffer,0,o),this.finished=!0}for(a=0;a<8;a++)e[4*a+0]=this.state[a]>>>24&255,e[4*a+1]=this.state[a]>>>16&255,e[4*a+2]=this.state[a]>>>8&255,e[4*a+3]=this.state[a]>>>0&255;return this},t.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},t.prototype._saveState=function(e){for(var t=0;t<this.state.length;t++)e[t]=this.state[t]},t.prototype._restoreState=function(e,t){for(var n=0;n<this.state.length;n++)this.state[n]=e[n];this.bytesHashed=t,this.finished=!1,this.bufferLength=0},t}();e.Hash=s;var r=function(){function e(e){this.inner=new s,this.outer=new s,this.blockSize=this.inner.blockSize,this.digestLength=this.inner.digestLength;var t=new Uint8Array(this.blockSize);if(e.length>this.blockSize)(new s).update(e).finish(t).clean();else for(var n=0;n<e.length;n++)t[n]=e[n];for(n=0;n<t.length;n++)t[n]^=54;for(this.inner.update(t),n=0;n<t.length;n++)t[n]^=106;for(this.outer.update(t),this.istate=new Uint32Array(8),this.ostate=new Uint32Array(8),this.inner._saveState(this.istate),this.outer._saveState(this.ostate),n=0;n<t.length;n++)t[n]=0}return e.prototype.reset=function(){return this.inner._restoreState(this.istate,this.inner.blockSize),this.outer._restoreState(this.ostate,this.outer.blockSize),this},e.prototype.clean=function(){for(var e=0;e<this.istate.length;e++)this.ostate[e]=this.istate[e]=0;this.inner.clean(),this.outer.clean()},e.prototype.update=function(e){return this.inner.update(e),this},e.prototype.finish=function(e){return this.outer.finished?this.outer.finish(e):(this.inner.finish(e),this.outer.update(e,this.digestLength).finish(e)),this},e.prototype.digest=function(){var e=new Uint8Array(this.digestLength);return this.finish(e),e},e}();function i(e){var t=(new s).update(e),n=t.digest();return t.clean(),n}function o(e,t){var n=new r(e).update(t),s=n.digest();return n.clean(),s}function a(e,t,n,s){var r=s[0];if(0===r)throw new Error("hkdf: cannot expand more");t.reset(),r>1&&t.update(e),n&&t.update(n),t.update(s),t.finish(e),s[0]++}e.HMAC=r,e.hash=i,e.default=i,e.hmac=o;var l=new Uint8Array(e.digestLength);e.hkdf=function(e,t,n,s){void 0===t&&(t=l),void 0===s&&(s=32);for(var i=new Uint8Array([1]),c=o(t,e),u=new r(c),h=new Uint8Array(u.digestLength),d=h.length,m=new Uint8Array(s),p=0;p<s;p++)d===h.length&&(a(h,u,n,i),d=0),m[p]=h[d++];return u.clean(),h.fill(0),i.fill(0),m},e.pbkdf2=function(e,t,n,s){for(var i=new r(e),o=i.digestLength,a=new Uint8Array(4),l=new Uint8Array(o),c=new Uint8Array(o),u=new Uint8Array(s),h=0;h*o<s;h++){var d=h+1;a[0]=d>>>24&255,a[1]=d>>>16&255,a[2]=d>>>8&255,a[3]=d>>>0&255,i.reset(),i.update(t),i.update(a),i.finish(c);for(var m=0;m<o;m++)l[m]=c[m];for(m=2;m<=n;m++){i.reset(),i.update(c).finish(c);for(var p=0;p<o;p++)l[p]^=c[p]}for(m=0;m<o&&h*o+m<s;m++)u[h*o+m]=l[m]}for(h=0;h<o;h++)l[h]=c[h]=0;for(h=0;h<4;h++)a[h]=0;return i.clean(),u}}(i);var o=i.default;for(var a in i)o[a]=i[a];"object"==typeof e.exports?e.exports=o:void 0===(s=function(){return o}.call(i,n,i,e))||(e.exports=s)}()},1811:(e,t,n)=>{"use strict";n.d(t,{T:()=>r});const s=new Uint32Array(65536),r=(e,t)=>{if(e.length<t.length){const n=t;t=e,e=n}return 0===t.length?e.length:e.length<=32?((e,t)=>{const n=e.length,r=t.length,i=1<<n-1;let o=-1,a=0,l=n,c=n;for(;c--;)s[e.charCodeAt(c)]|=1<<c;for(c=0;c<r;c++){let e=s[t.charCodeAt(c)];const n=e|a;e|=(e&o)+o^o,a|=~(e|o),o&=e,a&i&&l++,o&i&&l--,a=a<<1|1,o=o<<1|~(n|a),a&=n}for(c=n;c--;)s[e.charCodeAt(c)]=0;return l})(e,t):((e,t)=>{const n=t.length,r=e.length,i=[],o=[],a=Math.ceil(n/32),l=Math.ceil(r/32);for(let e=0;e<a;e++)o[e]=-1,i[e]=0;let c=0;for(;c<l-1;c++){let a=0,l=-1;const u=32*c,h=Math.min(32,r)+u;for(let t=u;t<h;t++)s[e.charCodeAt(t)]|=1<<t;for(let e=0;e<n;e++){const n=s[t.charCodeAt(e)],r=o[e/32|0]>>>e&1,c=i[e/32|0]>>>e&1,u=n|a,h=((n|c)&l)+l^l|n|c;let d=a|~(h|l),m=l&h;d>>>31^r&&(o[e/32|0]^=1<<e),m>>>31^c&&(i[e/32|0]^=1<<e),d=d<<1|r,m=m<<1|c,l=m|~(u|d),a=d&u}for(let t=u;t<h;t++)s[e.charCodeAt(t)]=0}let u=0,h=-1;const d=32*c,m=Math.min(32,r-d)+d;for(let t=d;t<m;t++)s[e.charCodeAt(t)]|=1<<t;let p=r;for(let e=0;e<n;e++){const n=s[t.charCodeAt(e)],a=o[e/32|0]>>>e&1,l=i[e/32|0]>>>e&1,c=n|u,d=((n|l)&h)+h^h|n|l;let m=u|~(d|h),f=h&d;p+=m>>>r-1&1,p-=f>>>r-1&1,m>>>31^a&&(o[e/32|0]^=1<<e),f>>>31^l&&(i[e/32|0]^=1<<e),m=m<<1|a,f=f<<1|l,h=f|~(c|m),u=m&c}for(let t=d;t<m;t++)s[e.charCodeAt(t)]=0;return p})(e,t)}},3979:(e,t)=>{"use strict";t.H$=void 0,t.H$=function(e,t,n){var s=function(e,t,n){if(0===e.length||0===t.length)return 0;if(n&&!n.caseSensitive&&(e=e.toUpperCase(),t=t.toUpperCase()),e===t)return 1;for(var s=0,r=e.length,i=t.length,o=Math.floor(Math.max(r,i)/2)-1,a=new Array(r),l=new Array(i),c=0;c<r;c++)for(var u=Math.max(0,c-o);u<=Math.min(i,c+o+1);u++)if(!a[c]&&!l[u]&&e[c]===t[u]){++s,a[c]=l[u]=!0;break}if(0===s)return 0;var h=0,d=0;for(c=0;c<r;c++)if(a[c]){for(;!l[d];)d++;e.charAt(c)!==t.charAt(d++)&&h++}return(s/r+s/i+(s-(h/=2))/s)/3}(e,t,n),r=0;if(s>.7){for(var i=Math.min(e.length,t.length),o=0;e[o]===t[o]&&o<4&&o<i;)++r,o++;s+=.1*r*(1-s)}return s}},9461:e=>{"use strict";var t=e.exports=function(e,t,s){"function"==typeof t&&(s=t,t={}),n(t,"function"==typeof(s=t.cb||s)?s:s.pre||function(){},s.post||function(){},e,"",e)};function n(e,s,r,i,o,a,l,c,u,h){if(i&&"object"==typeof i&&!Array.isArray(i)){for(var d in s(i,o,a,l,c,u,h),i){var m=i[d];if(Array.isArray(m)){if(d in t.arrayKeywords)for(var p=0;p<m.length;p++)n(e,s,r,m[p],o+"/"+d+"/"+p,a,o,d,i,p)}else if(d in t.propsKeywords){if(m&&"object"==typeof m)for(var f in m)n(e,s,r,m[f],o+"/"+d+"/"+f.replace(/~/g,"~0").replace(/\//g,"~1"),a,o,d,i,f)}else(d in t.keywords||e.allKeys&&!(d in t.skipKeywords))&&n(e,s,r,m,o+"/"+d,a,o,d,i)}r(i,o,a,l,c,u,h)}}t.keywords={additionalItems:!0,items:!0,contains:!0,additionalProperties:!0,propertyNames:!0,not:!0,if:!0,then:!0,else:!0},t.arrayKeywords={items:!0,allOf:!0,anyOf:!0,oneOf:!0},t.propsKeywords={$defs:!0,definitions:!0,properties:!0,patternProperties:!0,dependencies:!0},t.skipKeywords={default:!0,enum:!0,const:!0,required:!0,maximum:!0,minimum:!0,exclusiveMaximum:!0,exclusiveMinimum:!0,multipleOf:!0,maxLength:!0,minLength:!0,pattern:!0,format:!0,maxItems:!0,minItems:!0,uniqueItems:!0,maxProperties:!0,minProperties:!0}},3379:e=>{"use strict";var t=[];function n(e){for(var n=-1,s=0;s<t.length;s++)if(t[s].identifier===e){n=s;break}return n}function s(e,s){for(var i={},o=[],a=0;a<e.length;a++){var l=e[a],c=s.base?l[0]+s.base:l[0],u=i[c]||0,h="".concat(c," ").concat(u);i[c]=u+1;var d=n(h),m={css:l[1],media:l[2],sourceMap:l[3],supports:l[4],layer:l[5]};if(-1!==d)t[d].references++,t[d].updater(m);else{var p=r(m,s);s.byIndex=a,t.splice(a,0,{identifier:h,updater:p,references:1})}o.push(h)}return o}function r(e,t){var n=t.domAPI(t);return n.update(e),function(t){if(t){if(t.css===e.css&&t.media===e.media&&t.sourceMap===e.sourceMap&&t.supports===e.supports&&t.layer===e.layer)return;n.update(e=t)}else n.remove()}}e.exports=function(e,r){var i=s(e=e||[],r=r||{});return function(e){e=e||[];for(var o=0;o<i.length;o++){var a=n(i[o]);t[a].references--}for(var l=s(e,r),c=0;c<i.length;c++){var u=n(i[c]);0===t[u].references&&(t[u].updater(),t.splice(u,1))}i=l}}},569:e=>{"use strict";var t={};e.exports=function(e,n){var s=function(e){if(void 0===t[e]){var n=document.querySelector(e);if(window.HTMLIFrameElement&&n instanceof window.HTMLIFrameElement)try{n=n.contentDocument.head}catch(e){n=null}t[e]=n}return t[e]}(e);if(!s)throw new Error("Couldn't find a style target. This probably means that the value for the 'insert' parameter is invalid.");s.appendChild(n)}},9216:e=>{"use strict";e.exports=function(e){var t=document.createElement("style");return e.setAttributes(t,e.attributes),e.insert(t,e.options),t}},3565:(e,t,n)=>{"use strict";e.exports=function(e){var t=n.nc;t&&e.setAttribute("nonce",t)}},7795:e=>{"use strict";e.exports=function(e){if("undefined"==typeof document)return{update:function(){},remove:function(){}};var t=e.insertStyleElement(e);return{update:function(n){!function(e,t,n){var s="";n.supports&&(s+="@supports (".concat(n.supports,") {")),n.media&&(s+="@media ".concat(n.media," {"));var r=void 0!==n.layer;r&&(s+="@layer".concat(n.layer.length>0?" ".concat(n.layer):""," {")),s+=n.css,r&&(s+="}"),n.media&&(s+="}"),n.supports&&(s+="}");var i=n.sourceMap;i&&"undefined"!=typeof btoa&&(s+="\n/*# sourceMappingURL=data:application/json;base64,".concat(btoa(unescape(encodeURIComponent(JSON.stringify(i))))," */")),t.styleTagTransform(s,e,t.options)}(t,e,n)},remove:function(){!function(e){if(null===e.parentNode)return!1;e.parentNode.removeChild(e)}(t)}}}},4589:e=>{"use strict";e.exports=function(e,t){if(t.styleSheet)t.styleSheet.cssText=e;else{for(;t.firstChild;)t.removeChild(t.firstChild);t.appendChild(document.createTextNode(e))}}},7241:(e,t,n)=>{"use strict";n.d(t,{D:()=>c});var s=n(4469),r=n(976),i=n(7422),o=n(8607),a=n(6286);const l=31;async function c(e,t=!1,n){const a=o.g.forColumn(e);let c;n??(n=new Map);const h=a.isHelm()?(0,i.getHelmMonomers)(e):Object.keys(a.stats.freq).filter((e=>""!==e));for(let e=0;e<h.length;e++)n.has(h[e])||n.set(h[e],`${n.size+1}`);if(a.isHelm())c=await s.functions.call("HELM:getMolFiles",{col:e}),c=function(e,t,n=!1){const s=new Array(e.length);for(let r=0;r<e.length;r++){let i=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const c=e.get(r);i=c.indexOf("\n",i)+1,i=c.indexOf("\n",i)+1,i=c.indexOf("\n",i)+1;const u=parseInt(c.substring(i,i+3)),h=parseInt(c.substring(i+3,i+6));a+=`M V30 COUNTS ${u} ${h} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<u;e++){i=c.indexOf("\n",i)+1+l,o=c.indexOf(" ",i);const s=c.substring(i,o);a+=n?`M V30 ${e+1} R${t.get(s)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(s)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<h;e++){i=c.indexOf("\n",i)+1;const t=parseInt(c.substring(i,i+3).trim()),n=parseInt(c.substring(i+3,i+6).trim());a+=`M V30 ${e+1} ${parseInt(c.substring(i+6,i+9).trim())} ${t} ${n}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",s[r]=a}return s}(c,n,t);else{c=new Array(e.length);for(let s=0;s<e.length;s++){const e=u(a.getSplitted(s),n,t);c[s]=e}}return r.Column.fromStrings("monomericMols",c)}function u(e,t,n=!1){let s="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";s+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,s+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++){const i=e.getCanonical(r);i!==a.G2&&(s+=n?`M V30 ${r+1} R${t.get(i)} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(i)}\n`)}s+="M V30 END ATOM\n",s+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)s+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return s+="M V30 END BOND\n",s+="M V30 END CTAB\n",s+="M END",s}},7422:(e,t,n)=>{"use strict";n.r(t),n.d(t,{GetRegionEditor:()=>As,SeqActivityCliffsEditor:()=>Es,SeqPaletteCustom:()=>ms,SequenceSpaceEditor:()=>xs,SplitToMonomersEditor:()=>Ss,SubsequenceSearchTopMenu:()=>nr,_package:()=>us,activityCliffs:()=>ks,addCopyMenu:()=>fr,alignSequences:()=>Us,applyNotationProviderForCyclized:()=>xr,bioSubstructureFilter:()=>ar,compositionAnalysis:()=>Hs,compositionAnalysisWidget:()=>Is,convertDialog:()=>Ys,demoBioActivityCliffs:()=>br,demoBioAtomicLevel:()=>vr,demoBioHelmMsaSequenceSpace:()=>wr,demoBioSequenceSpace:()=>yr,demoBioSimilarityDiversity:()=>gr,detectMacromoleculeProbe:()=>Ar,diversitySearchTopMenu:()=>er,diversitySearchViewer:()=>Qs,fastaSequenceCellRenderer:()=>Ts,getBioLib:()=>ys,getHelmMonomers:()=>zs,getMolFromHelm:()=>Sr,getMonomerLib:()=>bs,getMonomerLibHelper:()=>hs,getRegion:()=>Rs,getRegionApp:()=>ur,getRegionHelmApp:()=>hr,getRegionPanel:()=>ws,getRegionTopMenu:()=>Os,getSeqHandler:()=>vs,helmPreprocessingFunction:()=>Fs,hydrophobPalette:()=>ds,importBam:()=>Ws,importFasta:()=>js,initBio:()=>fs,libraryPanel:()=>Cs,longSeqTableFasta:()=>mr,longSeqTableHelm:()=>pr,longSeqTableSeparator:()=>dr,macroMolColumnPropertyPanel:()=>_s,macromoleculeDifferenceCellRenderer:()=>Ns,macromoleculePreprocessingFunction:()=>Ds,manageMonomerLibraries:()=>ir,monomerCellRenderer:()=>Zs,multipleSequenceAlignmentDialog:()=>Vs,saveAsFasta:()=>or,sdfToJsonLib:()=>Cr,searchSubsequenceEditor:()=>tr,separatorSequenceCellRenderer:()=>Ms,sequenceAlignment:()=>$s,sequenceIdentityScoring:()=>sr,sequenceSimilarityScoring:()=>rr,sequenceSpaceTopMenu:()=>Gs,sequenceTooltip:()=>gs,similaritySearchTopMenu:()=>Js,similaritySearchViewer:()=>Xs,splitToMonomersTopMenu:()=>Ks,testDetectMacromolecule:()=>qs,toAtomicLevel:()=>Bs,vdRegionsViewer:()=>Ps,webLogoAggApp:()=>cr,webLogoLargeApp:()=>lr,webLogoViewer:()=>Ls});var s,r,i=n(4469),o=n(3870),a=n(976),l=n(3277),c=n(4628);(r=s||(s={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";var u=n(701),h=n(3379),d=n.n(h),m=n(7795),p=n.n(m),f=n(569),g=n.n(f),y=n(3565),b=n.n(y),v=n(9216),w=n.n(v),C=n(4589),A=n.n(C),S=n(9414),x={};x.styleTagTransform=A(),x.setAttributes=b(),x.insert=g().bind(null,"head"),x.domAPI=p(),x.insertStyleElement=w(),d()(S.Z,x),S.Z&&S.Z.locals&&S.Z.locals;var E=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};let T=null,_=null;function I(e,t){return e&&""!=e?e:t}class M{constructor(){this.learningRate={uiName:"Learninig rate",value:1,tooltip:"The initial learning rate for the embedding optimization"},this.nEpochs={uiName:"Epochs",value:0,tooltip:"The number of epochs to optimize embeddings via SGD. Computed automatically if set to 0"},this.nNeighbors={uiName:"Neighbors",value:15,tooltip:"The number of nearest neighbors to construct the fuzzy manifold"},this.spread={uiName:"Spread",value:1,tooltip:"The effective scale of embedded points, used with min distance to control \n the clumped/dispersed nature of the embedding"},this.minDist={uiName:"Min distance",value:.1,tooltip:"The effective minimum distance between embedded points, \n used with spread to control the clumped/dispersed nature of the embedding"},this.randomSeed={uiName:"Random seed",value:null,tooltip:"Random seed",type:"string"},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for KNN computations",type:"boolean",disableTooltip:"WebGPU is not available"},function(){return E(this,void 0,void 0,(function*(){if(!T&&(T=yield navigator.gpu.requestAdapter(),null==T))return null;const e=yield T.requestAdapterInfo();return e?I(e.description,I(e.vendor,"No GPU description available")):null}))}().then((e=>{e?this.useWebGPU.tooltip+=` (${e})`:(this.useWebGPU.value=!1,this.useWebGPU.disable=!0)}))}}class N{constructor(){this.epsilon={uiName:"Epsilon",value:10,tooltip:"Epsilon is learning rate"},this.perplexity={uiName:"Perplexity",value:30,tooltip:"Roughly how many neighbors each point influences"}}}Object.prototype.toString;const $="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;class L{constructor(){this.epsilon={uiName:"Epsilon",value:.01,tooltip:"Minimum distance between cluster points",min:0,max:2,step:.005},this.minPts={uiName:"Minimum points",value:4,tooltip:"Minimum number of points in cluster",min:1,max:1e3,step:1}}}class P{get algorithmOptions(){const e=this.methodsParams[this.methodInput.value],t={};return Object.keys(e).forEach((n=>{null!=e[n].value&&(t[n]=e[n].value)})),t}get dbScanOptions(){return{dbScanEpsilon:this.dbScanParams.epsilon.value??.01,dbScanMinPts:this.dbScanParams.minPts.value??4}}constructor(e={}){this.editorSettings={},this.plotEmbeddingsInput=o.boolInput("Plot embeddings",!0),this.clusterEmbeddingsInput=o.boolInput("Cluster embeddings",!0),this.preprocessingFunctionInputRoot=null,this.methods=[c.A.UMAP,c.A.T_SNE],this.columnFunctionsMap={},this.supportedFunctions={},this.availableMetrics=[],this.methodSettingsDiv=o.inputs([]),this.dbScanSettingsDiv=o.inputs([]),this.preprocessingFuncSettingsDiv=o.inputs([]),this.preprocessingFunctionSettings={},this.methodsParams={[c.A.UMAP]:new M,[c.A.T_SNE]:new N},this.dbScanParams=new L,this.editorSettings=e,this.editorSettings.enableMCL&&this.methods.push($),a.Func.find({tags:[l.n3]}).forEach((e=>{const t=e.options.get(l.vO)??"",n=e.friendlyName??e.name,s=e.options.get(l.ts)??"",r=e.options.get(l.q6)??"",i=e.options.get(l.dB)??"";this.editorSettings.semtype&&!t.includes(this.editorSettings.semtype)||this.editorSettings.type&&!s.includes(this.editorSettings.type)||this.editorSettings.units&&!r.includes(this.editorSettings.units)||(this.supportedFunctions[n]={func:e,semTypes:t?t.split(","):[],types:s?s.split(","):[],units:r?r.split(","):[],distanceFunctions:i?i.split(","):[]})})),this.tableInput=o.tableInput("Table",i.shell.tv.dataFrame,i.shell.tables,(()=>{this.onTableInputChanged()})),this.onTableInputChanged(),this.regenerateColInput(),this.onColumnInputChanged();let t=!1,n=!1;this.methodInput=o.choiceInput("Method",c.A.UMAP,this.methods,(()=>{t&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=o.icons.settings((()=>{t=!t,t?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):o.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.dbScanSettingsIcon=o.icons.settings((()=>{n=!n,n?this.createAlgorithmSettingsDiv(this.dbScanSettingsDiv,this.dbScanParams):o.empty(this.dbScanSettingsDiv)}),"Modify clustering parameters"),this.clusterEmbeddingsInput.classList.add("ml-dim-reduction-settings-input"),this.clusterEmbeddingsInput.root.prepend(this.dbScanSettingsIcon),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=o.inputs([]);const s=this.columnFunctionsMap[this.colInput.value.name];this.preprocessingFunctionInput=o.choiceInput("Encoding function",s[0],s,(()=>{this.onPreprocessingFunctionChanged()}));let r=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,r=!0),r||(o.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.preprocessingFunctionInputRoot.classList.add("ml-dim-reduction-settings-input");let u=!1;this.preprocessingFuncSettingsIcon=o.icons.settings((async()=>{u?o.empty(this.preprocessingFuncSettingsDiv):await this.createPreprocessingFuncParamsDiv(this.preprocessingFuncSettingsDiv,this.supportedFunctions[this.preprocessingFunctionInput.value].func),u=!u}),"Modify encoding function parameters"),this.preprocessingFunctionInputRoot.prepend(this.preprocessingFuncSettingsIcon),this.similarityMetricInput=o.choiceInput("Similarity","",[],null),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),this.onPreprocessingFunctionChanged()}getColInput(){const e=this.tableInput.value?.columns.toList().find((e=>!!this.columnFunctionsMap[e.name]))??null,t=o.columnInput("Column",this.tableInput.value,e,(()=>this.onColumnInputChanged()),{filter:e=>!!this.columnFunctionsMap[e.name]});return this.colInputRoot||(this.colInputRoot=t.root),t}regenerateColInput(){let e=!1;this.colInputRoot&&(e=!0,o.empty(this.colInputRoot)),this.colInput=this.getColInput(),e&&Array.from(this.colInput.root.children).forEach((e=>this.colInputRoot.append(e))),this.onColumnInputChanged()}onTableInputChanged(){const e=this.tableInput.value;e&&(this.columnFunctionsMap={},e.columns.toList().forEach((e=>{Object.keys(this.supportedFunctions).forEach((t=>{const n=this.supportedFunctions[t].semTypes,s=this.supportedFunctions[t].types,r=this.supportedFunctions[t].units,i=!n.length||e.semType&&n.includes(e.semType),o=!s.length||s.includes(e.type),l=!r.length||e.getTag(a.TAGS.UNITS)&&r.includes(e.getTag(a.TAGS.UNITS));i&&o&&l&&(this.columnFunctionsMap[e.name]||(this.columnFunctionsMap[e.name]=[]),this.columnFunctionsMap[e.name].push(t))}))})),this.regenerateColInput())}onColumnInputChanged(){const e=this.colInput.value;if(!e)return;const t=this.columnFunctionsMap[e.name];this.preprocessingFunctionInput=o.choiceInput("Preprocessing function",t[0],t,(()=>{this.onPreprocessingFunctionChanged()}));let n=!1;this.preprocessingFunctionInputRoot||(this.preprocessingFunctionInputRoot=this.preprocessingFunctionInput.root,n=!0),n||(o.empty(this.preprocessingFunctionInputRoot),Array.from(this.preprocessingFunctionInput.root.children).forEach((e=>this.preprocessingFunctionInputRoot.append(e)))),this.onPreprocessingFunctionChanged()}onPreprocessingFunctionChanged(){o.empty(this.preprocessingFuncSettingsDiv),this.preprocessingFunctionSettings={};const e=this.preprocessingFunctionInput.value,t=this.supportedFunctions[e].distanceFunctions;this.availableMetrics=[...t],this.similarityMetricInput=o.choiceInput("Similarity",this.availableMetrics[0],this.availableMetrics,null),this.similarityMetricInput.nullable=!1,this.similarityMetricInputRoot||(this.similarityMetricInputRoot=this.similarityMetricInput.root),o.empty(this.similarityMetricInputRoot),Array.from(this.similarityMetricInput.root.children).forEach((e=>this.similarityMetricInputRoot.append(e))),this.preprocessingFuncSettingsIcon&&(this.supportedFunctions[e].func.inputs.length<3?this.preprocessingFuncSettingsIcon.style.display="none":this.preprocessingFuncSettingsIcon.style.display="flex")}createAlgorithmSettingsDiv(e,t){return o.empty(e),Object.keys(t).forEach((n=>{const s=t[n],r="string"===s.type?o.stringInput(s.uiName,s.value??"",(()=>{s.value=r.value})):"boolean"===s.type?o.boolInput(s.uiName,s.value??!1,(()=>{s.value=r.value})):o.floatInput(s.uiName,s.value,(()=>{s.value=r.value}));e.append(r.root),s.disable?(r.enabled=!1,o.tooltip.bind(r.input??r.root,s.disableTooltip??"")):o.tooltip.bind(r.input??r.root,s.tooltip)})),e}async createPreprocessingFuncParamsDiv(e,t){if(o.empty(e),t.inputs.length<3)return o.div();const n=t.prepare(),s=await n.buildEditor(o.div());for(let r=2;r<t.inputs.length;r++){const i=t.inputs[r];(this.preprocessingFunctionSettings[i.name]||n.inputParams[t.inputs[r].name].value||i.defaultValue)&&(this.preprocessingFunctionSettings[i.name]=this.preprocessingFunctionSettings[i.name]??n.inputParams[i.name].value??i.defaultValue);const o=s.find((e=>e.property.name===i.name));o&&(null!==this.preprocessingFunctionSettings[i.name]&&void 0!==this.preprocessingFunctionSettings[i.name]&&(o.value=this.preprocessingFunctionSettings[i.name]),o.onChanged((()=>{this.preprocessingFunctionSettings[i.name]=o.value})),e.append(o.root))}return e}getEditor(){return o.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.plotEmbeddingsInput,this.clusterEmbeddingsInput,this.dbScanSettingsDiv],{style:{minWidth:"420px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{table:this.tableInput.value,col:this.colInput.value,methodName:this.methodInput.value,preprocessingFunction:this.supportedFunctions[this.preprocessingFunctionInput.value].func,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,clusterEmbeddings:this.clusterEmbeddingsInput.value,options:{...this.algorithmOptions,...this.dbScanOptions,preprocessingFuncArgs:this.preprocessingFunctionSettings??{}}}}}const R=rxjs.operators;var O=n(5697);const k=e=>null==e;function D(e,t,n,s){if(n>e[e.length-1])return;const r=e.findIndex((e=>n<e));e.pop(),e.splice(r,0,n),t.pop(),t.splice(r,0,s)}var F=n(6254);class G{constructor(e=!0,t=!0){const s=navigator.hardwareConcurrency;this._workerCount=e?Math.max(s-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(65),n.b)))),this._terminateOnComplete=t}async calc(e,t,n=!0,r){return await this.calcMulti([e],[t],n,[r??{}],[1],s.MANHATTAN)}async calcMulti(e,t,n=!0,r=[{}],i=[1],o=s.MANHATTAN){if(e.length<1)throw new Error("values must contain at least one array");if(t.length!==e.length||r.length!==e.length||i.length!==e.length)throw new Error("values, fnNames, weights and opts must have the same length");return new Promise((async(s,a)=>{try{const a=e[0].length,l=new Array(this._workerCount),c=a*(a-1)/2;this._workerCount=Math.min(this._workerCount,c);const u=c/this._workerCount,h=new Float32Array(c);let d=0,m=1,p=0,f=Number.MIN_VALUE;for(let n=0;n<this._workerCount;n++){const s=Math.floor(n*u),g=n===this._workerCount-1?c:Math.floor((n+1)*u),y=d,b=m;n!==this._workerCount-1&&(d=a-2-Math.floor(Math.sqrt(-8*g+4*a*(a-1)-7)/2-.5),m=g-a*d+Math.floor((d+1)*(d+2)/2)),this._workers[n].postMessage({values:e,fnNames:t,startRow:y,startCol:b,chunckSize:g-s,opts:r,weights:i,aggregationMethod:o}),l[n]=new Promise(((e,t)=>{this._workers[n].onmessage=({data:{error:r,distanceMatrixData:i,min:o,max:a}})=>{this._terminateOnComplete&&setTimeout((()=>this._workers[n].terminate())),r?t(r):(h.set(i,s),o<p&&(p=o),a>f&&(f=a),e())}}))}await Promise.all(l),n&&h.forEach(((e,t)=>{h[t]=(e-p)/(f-p)})),s(h)}catch(e){a(e)}}))}terminate(){this._workers.forEach((e=>e.terminate()))}}class B{constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,i=[{}],o=[1],a=s.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=e[0].length>2e4?await this.getMinimalThreshold(e,t,i,o,a):0;r<u&&(console.log(`using threshold ${u}`),r=u),i.forEach(((e,t)=>i[t].threshold=r));const h=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(23),n.b))));for(let n=0;n<this._workerCount;n++)h[n]=new Promise(((s,u)=>{const h=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=h&&s({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:n}),d[n].postMessage({values:e,startIdx:h,endIdx:m,threshold:r,fnNames:t,opts:i,weights:o,aggregationMethod:a}),d[n].onmessage=({data:{error:e,i:t,j:r,distance:i}})=>{e?(d[n].terminate(),u(e)):(d[n].terminate(),s({i:t,j:r,distance:i,idx:n}))}}));const m=await Promise.all(h),p=m.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(p),g=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,n,s={}){return await this.calcMultiColumn([e],[t],n,[s],[1])}async getKNN(e,t,n=15,s={}){return await this.multiColumnKNN([e],[t],n,[s],[1])}async getThresholdKNN(e,t,n=.8,s={}){return await this.multiColumnThresholdKnn([e],[t],n,[s],[1])}async multiColumnThresholdKnn(e,t,r=.8,i,o,a=s.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(427),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((s,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&s({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,threshold:r,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),s({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),m=new Int32Array(e[0].length);for(const t of d)for(let n=0;n<e[0].length;++n)m[n]+=t.knnIndexes[n]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t])))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)p.knnDistances[n][m[n]-1]=t.knnDistances[n][e],p.knnIndexes[n][m[n]-1]=t.knnIndexes[n][e],m[n]-=1;return p}async multiColumnKNN(e,t,r=15,i,o,a=s.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),u=new Array(this._workerCount),h=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(282),n.b))));for(let n=0;n<this._workerCount;n++)u[n]=new Promise(((s,u)=>{const d=n*c,m=n===this._workerCount-1?l:(n+1)*c;m<=d&&s({knnDistances:new Array(0),knnIndexes:new Array(0)}),h[n].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,nNeighbours:r,weights:o,aggregationMethod:a}),h[n].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(h[n].terminate(),u(e)):(h[n].terminate(),s({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(u),m={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let n=0;n<e[0].length;++n)for(let e=0;e<t.knnDistances[n]?.length;++e)D(m.knnDistances[n],m.knnIndexes[n],t.knnDistances[n][e],t.knnIndexes[n][e]);return m}async getSampleDistances(e,t,r=[],i,o=s.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(n.p+n.u(40),n.b))));try{const n=e[0].length*(e[0].length-1)/2,s=Math.floor(n/this._workerCount),l=1e6,c=Math.max(Math.min(n/1e3,l),Math.min(n,l)),u=Math.floor(c/this._workerCount),h=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)h[l]=new Promise(((c,h)=>{const d=l*s,m=l===this._workerCount-1?n:(l+1)*s;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:u,fnNames:t,opts:r,weights:i,aggregationMethod:o}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?h(e):c({distance:t})}}));const d=await Promise.all(h),m=d.reduce(((e,t)=>e+t.distance.length),0),p=new Float32Array(m);let f=0;for(const e of d)p.set(e.distance,f),f+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,n=[],r,i=s.EUCLIDEAN){try{const s=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,n,r,i);return 1-o[Math.floor(7e7/s*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,n,s){const r=[],i=[],o=[];let a=0,l=0,c=0;const u=e.length*(e.length-1)/2;for(;a<u;){const t=k(e[l])||k(e[c])?1:n(e[l],e[c]);1-t>=s&&(r.push(l),i.push(c),o.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(i),distance:new Float32Array(o)}}}var V,U,H=n(9657);(U=V||(V={})).none="none",U.bold="bold",U.dashed="dashed";class j{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,n,s,r=V.none){var i;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(n),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(s),this.visibility=null!==(i=s.visibility)&&void 0!==i?i:new H.Z(this.lines.from.length),s.visibility||this.visibility.setAll(!0,!1),s.arrowSize&&(this.arrowWidth=s.arrowSize),this.canvas.onmousedown=e=>{-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,n,s,r,i,o,a,l,c,u,h,d;const m=this.sp.getOptions().look,p=this.lines.colors||this.lines.width||this.lines.opacities||this.lines.drawArrowsArr;p||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(n=this.lines.opacity)&&void 0!==n?n:1})`);const f=m.sizeColumnName?this.sp.dataFrame.col(m.sizeColumnName):null,g=this.sp.dataFrame.filter;for(let e=0;e<this.lines.from.length;e++)if(g.get(this.lines.from[e])&&g.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:n,sizeTo:g}=this.getMarkersSizes(m,f,e),y=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let b=null==y?void 0:y.x,v=null==y?void 0:y.y;const w=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let C=null==w?void 0:w.x,A=null==w?void 0:w.y;const S=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),b&&v&&C&&A&&Math.hypot(C-b,A-v)/S>.01){if(p){const t=(null===(s=this.lines.colors)||void 0===s?void 0:s[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:"0,128,0",n=(null===(i=this.lines.opacities)||void 0===i?void 0:i[e])?null===(o=this.lines.opacities)||void 0===o?void 0:o[e]:1;this.ctx.strokeStyle=`rgba(${t},${n})`,this.ctx.lineWidth=(null===(a=this.lines.widths)||void 0===a?void 0:a[e])?null===(l=this.lines.widths)||void 0===l?void 0:l[e]:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const m=this.multipleLinesCounts[e];let f=null;if(m){t=this.getLineLength(b,v,C,A);const s=this.getPointOnDistance(b,v,C,A,g,t),r=this.getPointOnDistance(C,A,b,v,n,t);b=s.x,v=s.y,C=r.x,A=r.y,f=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(m,b,v,C,A,e):this.findControlPoint(m,C,A,b,v,e),this.ctx.moveTo(b,v),this.ctx.quadraticCurveTo(f.x,f.y,C,A)}else this.ctx.moveTo(b,v),this.ctx.lineTo(C,A);if((null!==(c=this.lines.drawArrows)&&void 0!==c?c:null===(u=this.lines.drawArrowsArr)||void 0===u?void 0:u.getBit(e))&&(t||(t=this.getLineLength(b,v,C,A)),t>this.arrowWidth)){const e=m?null:this.getPointOnDistance(b,v,C,A,g,t),n=m?f.x:b,s=m?f.y:v;this.canvasArrow(this.ctx,null!==(h=null==e?void 0:e.x)&&void 0!==h?h:b,null!==(d=null==e?void 0:e.y)&&void 0!==d?d:v,n,s)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case V.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case V.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,n){let s=3,r=3;return t?(s=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[n]))/2,r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[n]))/2):e.markerDefaultSize&&(s=e.markerDefaultSize/2,r=e.markerDefaultSize/2),{sizeFrom:s,sizeTo:r}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e=new H.Z(this.lines.from.length);e.setAll(!0);for(let t=-1;-1!==(t=e.findNext(t));){const n=t,s=this.lines.from[n],r=this.lines.to[n];let i=1;for(let n=t;-1!==(n=e.findNext(n));){const t=this.lines.from[n],o=this.lines.to[n];(t===s&&o===r||o===s&&t===r)&&(this.multipleLinesCounts[n]=++i,e.setBit(n,!1,!1))}i>1&&(this.multipleLinesCounts[n]=1),e.setBit(t,!1,!1)}}checkCoordsOnLine(e,t){let n=-1,s=null,r=null;const i=this.sp.getOptions().look,o=i.sizeColumnName?this.sp.dataFrame.col(i.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let l=0;l<this.lines.from.length;l++)if(a.get(this.lines.from[l])&&a.get(this.lines.to[l])&&this.visibility.getBit(l)){const{sizeFrom:a,sizeTo:c}=this.getMarkersSizes(i,o,l),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[l]),this.yAxisCol.get(this.lines.from[l])),h=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[l]),this.yAxisCol.get(this.lines.to[l]));if(this.multipleLinesCounts[l]){const n=this.getLineLength(u.x,u.y,h.x,h.y),s=this.getPointOnDistance(u.x,u.y,h.x,h.y,c,n),i=this.getPointOnDistance(h.x,h.y,null==u?void 0:u.x,null==u?void 0:u.y,a,n),o=this.lines.from[l]>this.lines.to[l]?this.findControlPoint(this.multipleLinesCounts[l],s.x,s.y,i.x,i.y,l):this.findControlPoint(this.multipleLinesCounts[l],i.x,i.y,s.x,s.y,l);r=this.calculateDistToCurveLine(l,e,t,s,i,o)}else r=this.calculateDistToStraightLine(e,t,u,h);(!s&&null!==r&&r<5||s&&null!==r&&r<s)&&(s=r,n=l)}return n}calculateDistToStraightLine(e,t,n,s){const r=Math.min(n.x,s.x),i=Math.max(n.x,s.x),o=Math.min(n.y,s.y),a=Math.max(n.y,s.y);return e>=r-2&&e<=i+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,n,s):null}distToStraightLineSegment(e,t,n,s){const r=(e,t,n,s)=>Math.pow(e-n,2)+Math.pow(t-s,2),i=r(n.x,n.y,s.x,s.y);if(0==i)return r(e,t,n.x,n.y);let o=((e-n.x)*(s.x-n.x)+(t-n.y)*(s.y-n.y))/i;return o=Math.max(0,Math.min(1,o)),r(e,t,n.x+o*(s.x-n.x),n.y+o*(s.y-n.y))}calculateDistToCurveLine(e,t,n,s,r,i){const o=Math.min(s.x,r.x,i.x),a=Math.max(s.x,r.x,i.x),l=Math.min(s.y,r.y,i.y),c=Math.max(s.y,r.y,i.y);if(t>=o-2&&t<=a+2&&n>=l-2&&n<=c+2){const e=a-o,u=c-l;return this.calculateDistToCurveInRect(t,n,s,i,r,e,u)}return null}calculateDistToCurveInRect(e,t,n,s,r,i,o){const a=Math.floor((i+o)/3),l=1/a,c=new Uint32Array(a),u=new Uint32Array(a),h=new Uint32Array(a);let d=null;const m=new H.Z(a);for(let i=0;i<c.length;i++){const o=i*l,a=Math.pow(1-o,2)*n.x+2*o*(1-o)*s.x+Math.pow(o,2)*r.x,m=Math.pow(1-o,2)*n.y+2*o*(1-o)*s.y+Math.pow(o,2)*r.y,p=Math.abs(e-a),f=Math.abs(t-m),g=p+f;(!d||d>g)&&(d=g),h[i]=Math.max(p,f),c[i]=a,u[i]=m}for(let e=0;e<c.length;e++)h[e]<d&&m.setBit(e,!0,!1);let p=null;for(let n=-1;-1!==(n=m.findNext(n));){const s=Math.hypot(c[n]-e,u[n]-t);(!p||p>s)&&(p=s)}return p}getLineLength(e,t,n,s){return Math.sqrt(Math.pow(n-e,2)+Math.pow(s-t,2))}getPointOnDistance(e,t,n,s,r,i){const o=n-r*((n-e)/i),l=s-r*((s-t)/i);return new a.Point(o,l)}findControlPoint(e,t,n,s,r,i){const o=t+(s-t)/2,l=n+(r-n)/2;let c=o-t,u=l-n;const h=Math.sqrt(c*c+u*u);c/=h,u/=h;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(o+d/2*u,l-d/2*c):new a.Point(o-d/2*u,l+d/2*c)}canvasArrow(e,t,n,s,r){const i=Math.atan2(s-t,r-n)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(i-Math.PI/10),n-this.arrowWidth*Math.cos(i-Math.PI/10)),e.lineTo(t,n),e.lineTo(t-this.arrowWidth*Math.sin(i+Math.PI/10),n-this.arrowWidth*Math.cos(i+Math.PI/10))}}const W="dimensionality-reducer-terminate-event";var Y,Z,q=n(850);async function K(e,t,s,r,o,a,l){let c=await async function(e,t,s,r,o,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,u){const h=new Worker(new URL(n.p+n.u(42),n.b));h.postMessage({columnsData:e,distanceMetrics:t,method:s,options:a,weights:r,aggregationMethod:o});const d=i.events.onCustomEvent(W).subscribe((()=>{try{h?.terminate()}finally{d.unsubscribe()}}));h.onmessage=({data:{error:e,embedding:t,epochNum:n,epochsLength:s}})=>{k(n)||k(s)?(d.unsubscribe(),e?u(e):c(t),setTimeout((()=>h.terminate()),100)):l&&l(n,s,t)}}))}(e,s,t,r,o,a,l);return c=c.map((e=>(0,q.Fv)(e))),c}(Z=Y||(Y={})).EUCLIDEAN="EUCLIDEAN",Z.MANHATTAN="MANHATTAN";const z={[Y.EUCLIDEAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + distances[i] * distances[i] * computeInfo.weights[i] * computeInfo.weights[i];\n }\n return sqrt(sum);\n `},[Y.MANHATTAN]:function(e){return`\n var sum = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n sum = sum + abs(distances[i]) * computeInfo.weights[i];\n }\n return sum;\n `}};var X,J;(J=X||(X={})).HAMMING="Hamming",J.EUCLIDEAN="Euclidean",J.MANHATTAN="Manhattan",J.TANIMOTO="Tanimoto",J.LEVENSTEIN="Levenshtein",J.NEEDLEMAN_WUNSCH="Needlemann-Wunsch",J.MONOMER_CHEMICAL_DISTANCE="Monomer chemical distance",J.SOKAL="Sokal",J.COSINE="Cosine",J.ASYMMETRIC="Asymmetric",J.Difference="Difference",J.OneHot="One-Hot";const Q={[X.HAMMING]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + f32(a[i] != b[i]);\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[X.EUCLIDEAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + f32(a[i] - b[i]) * f32(a[i] - b[i]);\n }\n return sqrt(dist);\n `},[X.MANHATTAN]:function(e,t){return`\n var dist: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n dist = dist + abs(f32(a[i] - b[i]));\n }\n return dist;\n `},[X.TANIMOTO]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n\n if (onBitsa == 0u && onBitsb == 0u) {\n return 0.0;\n }\n\n let totalOnBits = onBitsa + onBitsb;\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n\n return 1.0 - f32(commonBits) / f32(totalOnBits - commonBits);\n `},[X.LEVENSTEIN]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n\n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = f32(i);\n }\n\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n dynamicPassMat[curIndex][0] = f32(i);\n var minEntry: f32 = f32(maxLength);\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n let bMon = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n var cost: f32 = f32(a[j - 1] != bMon);\n var res: f32 = min(\n min(\n (*prevRow)[j] + 1.0, // deletion\n (*curRow)[j - 1] + 1.0, // insertion\n ),\n (*prevRow)[j - 1] + cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n `},[X.NEEDLEMAN_WUNSCH]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength));\n // we will store two arrays as matrix and swap the working indices per pass.\n // this way we can reduce memory usage per computation to just O(aLength)\n // the grid will have aLength + 1 columns and bLength + 1 rows\n // this will be guaranteed by iteration, but the array sizes must be known at compile time, so we will use a fixed size of maxArraySize\n var dynamicPassMat: array<array<f32, ${e+1}u>, 2>; // initialize to 0\n \n // we need to keep track of which operation led to the current cell\n // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n var verticalGaps: array<u32, ${e+1}u>;\n var horizontalGaps: array<u32, ${e+1}u>;\n\n let gapOpenPenalty: f32 = suppInfo.gapOpenPenalty${t};\n let gapExtensionPenalty: f32 = suppInfo.gapExtensionPenalty${t};\n var prevIndex: u32 = 0;\n var curIndex: u32 = 1; // we will swap these indices per pass\n // initialize the first row\n for (var i = 0u; i <= aLength; i = i + 1u) {\n dynamicPassMat[prevIndex][i] = gapOpenPenalty + f32(i - 1) * gapExtensionPenalty;\n dynamicPassMat[curIndex][i] = 0.0;\n }\n dynamicPassMat[0][0] = 0.0;\n\n let simMatrix = &suppInfo.similarityMatrix${t}; // using pointers make things faster\n // iterate over the rows\n for (var i = 1u; i <= bLength; i = i + 1u) {\n let prevRow = &dynamicPassMat[prevIndex];\n let curRow = &dynamicPassMat[curIndex];\n (*curRow)[0] = gapOpenPenalty + f32(i - 1) * gapExtensionPenalty;\n var minEntry: f32 = f32(maxLength);\n let monB = u32(b[i - 1]);\n for (var j = 1u; j <= aLength; j = j + 1u) {\n let monA = u32(a[j - 1]);\n \n let cost: f32 = (*prevRow)[j - 1] + 1f - (*simMatrix)[monA][monB];\n var top = (*prevRow)[j]; // deletion\n if (verticalGaps[j] > 0) {\n top = top + gapExtensionPenalty;\n } else {\n top = top + gapOpenPenalty;\n }\n var left = (*curRow)[j - 1]; // insertion\n if (horizontalGaps[j - 1] > 0) {\n left = left + gapExtensionPenalty;\n } else {\n left = left + gapOpenPenalty;\n }\n var res: f32 = min(\n min(\n top, // deletion\n left, // insertion\n ),\n cost // substitution\n );\n (*curRow)[j] = res;\n if (res < minEntry) {\n minEntry = res;\n }\n // update the horizontal and vertical gaps\n if (res == cost) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 0;\n } else if (res == left) {\n verticalGaps[j] = 0;\n horizontalGaps[j] = 1;\n } else {\n verticalGaps[j] = 1;\n horizontalGaps[j] = 0;\n }\n }\n // swap the indices\n let temp: u32 = prevIndex;\n prevIndex = curIndex;\n curIndex = temp;\n if (minEntry > maxIntDistance) {\n return 1.0;\n }\n }\n return dynamicPassMat[prevIndex][aLength] / f32(maxLength);\n \n `},[X.MONOMER_CHEMICAL_DISTANCE]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n let maxLength: u32 = max(aLength, bLength);\n let minLength: u32 = min(aLength, bLength);\n let sizeDiff: u32 = maxLength - minLength;\n \n let maxIntDistance = ceil(maxDistance * f32(maxLength)) - f32(sizeDiff);\n\n let simMatrix = &(suppInfo.similarityMatrix${t}); // using pointers make things faster\n var diff: f32 = 0.0;\n for (var i = 0u; i < ${e}; i = i + 1u) {\n diff = diff + 1.0 - (*simMatrix)[u32(a[i])][u32(b[i])];\n if (diff > maxIntDistance) {\n return 1.0;\n }\n }\n diff += f32(sizeDiff);\n return diff / ${e};\n `},[X.SOKAL]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa + onBitsb;\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(total * 2 - commonBits * 3);\n `},[X.COSINE]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let total = onBitsa * onBitsb; // p.s. here total is taken by multiplying\n if (total == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / sqrt(f32(total));\n `},[X.ASYMMETRIC]:function(e,t){return`\n var onBitsa: u32 = 0u;\n var onBitsb: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n onBitsa = onBitsa + countOneBits(a[i]);\n onBitsb = onBitsb + countOneBits(b[i]);\n }\n let min = min(onBitsa, onBitsb);\n if (min == 0u) {\n return 1.0;\n }\n var commonBits: u32 = 0u;\n for (var i = 0u; i < ${e}u; i = i + 1u) {\n commonBits = commonBits + countOneBits(a[i] & b[i]);\n }\n return 1.0 - f32(commonBits) / f32(min);\n `},[X.Difference]:function(e,t){return`\n let range = suppInfo.range${t};\n return f32(abs(f32(a[0]) - f32(b[0])) / range);\n `},[X.OneHot]:function(e,t){return`\n let aLength: u32 = computeInfo.entrySizes[${t}][aIndex];\n let bLength: u32 = computeInfo.entrySizes[${t}][bIndex];\n if (aLength != bLength) {\n return 1.0;\n }\n for (var i = 0u; i < aLength; i = i + 1u) {\n if(a[i] != b[i]) {\n return 1.0;\n }\n }\n return 0.0;\n `}},ee={[X.HAMMING]:e=>Math.ceil(e/30),[X.EUCLIDEAN]:e=>Math.ceil(e/30),[X.MANHATTAN]:e=>Math.ceil(e/30),[X.TANIMOTO]:e=>Math.ceil(e/60),[X.SOKAL]:e=>Math.ceil(e/60),[X.COSINE]:e=>Math.ceil(e/60),[X.ASYMMETRIC]:e=>Math.ceil(e/60),[X.LEVENSTEIN]:e=>Math.ceil(e*e/60),[X.NEEDLEMAN_WUNSCH]:e=>Math.ceil(e*e/60),[X.MONOMER_CHEMICAL_DISTANCE]:e=>Math.ceil(e/25),[X.Difference]:e=>1,[X.OneHot]:e=>Math.ceil(e/40)},te={STRING:new Set([X.HAMMING,X.LEVENSTEIN,X.NEEDLEMAN_WUNSCH,X.MONOMER_CHEMICAL_DISTANCE,X.OneHot]),UINT32ARRAY:new Set([X.HAMMING,X.EUCLIDEAN,X.MANHATTAN,X.MONOMER_CHEMICAL_DISTANCE,X.LEVENSTEIN,X.NEEDLEMAN_WUNSCH,X.TANIMOTO,X.COSINE,X.SOKAL,X.ASYMMETRIC,X.OneHot,X.Difference]),INT32ARRAY:new Set([X.EUCLIDEAN,X.MANHATTAN,X.OneHot,X.Difference]),FLOAT32ARRAY:new Set([X.EUCLIDEAN,X.MANHATTAN,X.Difference]),NUMBER:new Set([X.EUCLIDEAN,X.MANHATTAN,X.Difference]),BITARRAY:new Set([X.TANIMOTO,X.COSINE,X.SOKAL,X.ASYMMETRIC])};var ne=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function se(e,t,n,s){return e.map(((e,s)=>`\n fn distanceScript${s}(aIndex: u32, bIndex: u32) -> f32 {\n let a = computeInfo.data${s}[aIndex];\n let b = computeInfo.data${s}[bIndex];\n let maxDistance: f32 = ${n};\n ${Q[e](t[s],s)}\n }\n `)).join("\n")+"\n"+`\n fn combinedDistance(aIndex: u32, bIndex: u32) -> f32 {\n var distances: array<f32, ${e.length}>;\n ${e.map(((e,t)=>`distances[${t}] = distanceScript${t}(aIndex, bIndex);`)).join("\n")}\n ${z[s](e.length)}\n }\n \n `}let re=0;const ie="cliffsDf",oe=new u.Subject,ae="activity_difference",le="SALI_index",ce="similarity",ue="line_index",he=["1_molecule","2_molecule"],de="filterCliffs";async function me(e,t,s,r,l,c,u,h,d,m,p,f,g,y,b,v){re++;const w=c/100;let C,A=!1;const S=f.inputs,x=await f.apply({[S[0].name]:t,[S[1].name]:u,...d.preprocessingFuncArgs??{}});let I=[];if(h===$){const t=await function(e,t,s,r,i,o,a=10,l=!1,c=2){const u=new Worker(new URL(n.p+n.u(231),n.b));let h;return u.postMessage({data:e,threshold:t,weights:s,aggregationMethod:r,distanceFns:i,distanceFnArgs:o,maxIterations:a,useWebGPU:l,inflate:c}),{promise:new Promise(((e,t)=>{h=e,u.onmessage=t=>{setTimeout((()=>u.terminate()),100),e(t.data.res)},u.onerror=e=>{setTimeout((()=>u.terminate()),100),t(e)}})),terminate:()=>{try{h(null),u.terminate()}catch(e){console.error(e)}}}}([x.entries],c,[1],"MANHATTAN",[u],[x.options??{}],d?.maxIterations??5,d.useWebGPU??!1).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),I=[t.embedX,t.embedY]}else I=await K([x.entries],h,[u],[1],"MANHATTAN",{...d,distanceFnArgs:[x.options??{}]});if(I.length!==s.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<I.length;++t)e.columns.addNewFloat(s[t]).init((e=>I[t][e]));let M=null;if(d.useWebGPU)try{M=await function(e,t=.8,n,s,r,i){return ne(this,void 0,void 0,(function*(){const o=yield function(){return E(this,void 0,void 0,(function*(){if(!T&&(T=yield navigator.gpu.requestAdapter({powerPreference:"high-performance"}),null==T))return null;let e=!1;if(_&&(_.lost.then((()=>{e=!0})),yield new Promise((e=>setTimeout(e,10)))),!_||e){const e=1e9,t=T.limits,n=t.maxBufferSize,s=t.maxStorageBufferBindingSize;try{return _=yield T.requestDevice({requiredLimits:{maxBufferSize:Math.min(n,e),maxStorageBufferBindingSize:Math.min(s,e)}}),_}catch(e){return console.error("Failed to create device with required limits",e),_=yield T.requestDevice(),_}}return _}))}();if(!o)return null;const a=Object.values(X);if(n.some((e=>!a.includes(e))))throw new Error("Invalid distance metrics provided: "+n.join(", "));if(!Object.values(Y).includes(s))throw new Error("Invalid aggregation function provided: "+s);const l=1-t;if(i.length!==e.length||i.length!==n.length||i.length!==r.length)throw new Error("Options, weigths and distance functions must be provided for each column");if(e.some((t=>t.length!==e[0].length)))throw new Error("All entry lists must be the same length");const c=e.length,u=e[0].length,h=e.map(((e,t)=>function(e,t=X.HAMMING,n,s={gapOpenPenalty:1,gapExtensionPenalty:.6}){var r,i;let o=null;const a=e.some((e=>"string"==typeof e))?(o="STRING",e.map((e=>new Uint32Array(e.split("").map((e=>e.charCodeAt(0))))))):e.some((e=>"number"==typeof e))?(o="NUMBER",e.map((e=>new Float32Array([e])))):"object"==typeof e[0]&&e.some((e=>"_data"in e&&"_length"in e))?(o="BITARRAY",e.map((e=>e._data))):e.some((e=>e instanceof Float32Array))?(o="FLOAT32ARRAY",e):e.some((e=>e instanceof Uint32Array))?(o="UINT32ARRAY",e):e.some((e=>e instanceof Int32Array))?(o="INT32ARRAY",e):void 0;if(!a||!o)throw new Error("Invalid entry type, could not determine entry type from input list");const l=a[0]instanceof Int32Array?"INT32ARRAY":a[0]instanceof Float32Array?"FLOAT32ARRAY":"UINT32ARRAY",c=new Uint32Array(a.map((e=>e.length)));if(!te[o]||!te[o].has(t))throw new Error(`Distance metric '${t}' not supported for entry type '${o}'`);const u=c.reduce(((e,t)=>Math.max(e,t)),0),h=ee[t](u),d="INT32ARRAY"===l?Int32Array:"FLOAT32ARRAY"===l?Float32Array:Uint32Array,m=new d(a.length*u);a.forEach(((e,t)=>{m.set(e,t*u)}));let p="",f=0,g="FLOAT32ARRAY",y=null;if(t===X.NEEDLEMAN_WUNSCH||t===X.MONOMER_CHEMICAL_DISTANCE){let e=s.scoringMatrix&&s.alphabetIndexes?Object.keys(s.alphabetIndexes).reduce(((e,t)=>Math.max(e,t.charCodeAt(0))),0):-1;if(!s.alphabetIndexes||!s.scoringMatrix){for(let t=0;t<m.length;t++)m[t]>e&&(e=m[t]);s.scoringMatrix=new Array(e+1).fill(null).map((()=>new Array(e+1).fill(0))),s.alphabetIndexes={};for(let e=0;e<s.scoringMatrix.length;e++)s.scoringMatrix[e][e]=1,s.alphabetIndexes[String.fromCharCode(e)]=e}const t=(e+1)*(e+1),o=new Array(e+1).fill(null).map((()=>new Float32Array(e+1)));for(let t=0;t<e+1;t++)o[t][t]=1;const a=s.alphabetIndexes;for(const e of Object.keys(a))for(const t of Object.keys(a))e!==t&&(o[e.charCodeAt(0)][t.charCodeAt(0)]=s.scoringMatrix[a[e]][a[t]]);f=2+t,g="FLOAT32ARRAY",y=new Float32Array(f),y[0]=null!==(r=s.gapOpenPenalty)&&void 0!==r?r:1,y[1]=null!==(i=s.gapExtensionPenalty)&&void 0!==i?i:.6;let l=2;for(let e=0;e<o.length;e++)y.set(o[e],l),l+=o[e].length;p=`\n gapOpenPenalty${n}: f32,\n gapExtensionPenalty${n}: f32,\n similarityMatrix${n}: array<array<f32, ${e+1}>, ${e+1}>`}else if(t===X.Difference){if(!s.range||"number"!=typeof s.range||s.range<=0){const e=m.reduce(((e,t)=>Math.min(e,t)),m[0]),t=m.reduce(((e,t)=>Math.max(e,t)),m[0]);s.range=t-e}s.range<=0&&(s.range=1),f=1,g="FLOAT32ARRAY",y=new Float32Array([s.range]),p=`\n range${n}: f32`}const b=m instanceof Int32Array?"i32":m instanceof Float32Array?"f32":"u32",v=`data${n}: array<array<${b}, ${u}>, ${a.length}>`;return{flatSourceArray:m,sourceArraySize:m.length,maxEntryLen:u,arraySizes:c,complexity:h,suppInfoBuffer:y,suppInfoSize:f,suppInfoType:g,suppInfoStructWgsl:p,entryType:o,dataTypeWGSL:b,dataStructWgsl:v,EncodedArrayConstructor:d}}(e,n[t],t,i[t])));if(0===c)throw new Error("No columns provided. Please provide at least one column of data.");1===c&&(s=Y.MANHATTAN);let d=h.map((e=>e.suppInfoStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),m=!1;d&&""!=d.trim()||(m=!0,d="\ndummy: f32\n");const p=h.map((e=>e.dataStructWgsl)).filter((e=>!!e&&""!=e)).join(",\n"),f=new Uint32Array(c*u);h.forEach(((e,t)=>{f.set(e.arraySizes,t*u)}));const g=1e4,y=100,b=h.reduce(((e,t)=>e+t.complexity),0),v=Math.ceil(1e4/b),w=Math.ceil(Math.sqrt(Math.ceil(100))),C=10*w,A=u*(u-1)/2,S=Math.ceil(A/g),x=o.createShaderModule({label:"Sparse matrix compute shader",code:`\n // each thread will perform 100 iterations at one time, comparing 100 pairs of entries.\n // in total, each thread will perform at most ${S} comparisons.\n // first is the result struct, containing is, js, and distances. each array with length of 100,\n // and also integer for how many pairs were found to be below threshold.\n struct SparseResult {\n i: array<array<u32, 100>, 10000>,\n j: array<array<u32, 100>, 10000>,\n distances: array<array<f32, 100>, 10000>,\n found: array<u32, 10000>,\n done: array<u32, 10000>\n }\n // struct for the data\n struct ComputeInfo {\n // start at cols and rows, and end at cols and rows for each thread, these will be calculated on cpu and passed to gpu.\n startAtCols: array<u32, 10000>,\n startAtRows: array<u32, 10000>,\n endAtCols: array<u32, 10000>,\n endAtRows: array<u32, 10000>,\n\n // the ACTUALLY sizes of each entry\n entrySizes: array<array<u32, ${u}>, ${c}>,\n // the weights for each entry\n weights: array<f32, ${c}>,\n // the data for each entry\n ${p} // an example of the dataWgsl would be:\n //data0: array<array<u32,20>,100>,\n //data1: array<array<u32,20>,100>\n }\n\n // struct for the supplementary information\n struct SuppInfo {\n // struct containing all the supplementary info, like scoring matrix, alphabet indexes, range, etc.\n ${d}\n };\n\n @group(0) @binding(0) var<storage, read_write> computeInfo: ComputeInfo;\n @group(0) @binding(1) var<storage, read_write> suppInfo: SuppInfo;\n @group(0) @binding(2) var<storage, read_write> results: SparseResult;\n @compute @workgroup_size(10, 10) fn calcSparseMatrix(\n @builtin(global_invocation_id) id: vec3<u32>\n ) {\n ${m?"let otherDummy = suppInfo.dummy * 2;":""} // just to make sure that the suppInfo is not optimized out\n let threadCol = id.x;\n let threadRow = id.y;\n let linearIndex = threadRow * ${C} + threadCol;\n if (linearIndex >= 10000) {\n return; // if we are out of bounds, return\n } \n var startAtCol: u32 = computeInfo.startAtCols[linearIndex];\n var startAtRow: u32 = computeInfo.startAtRows[linearIndex];\n let endAtCol: u32 = min(computeInfo.endAtCols[linearIndex], ${u}u);\n let endAtRow: u32 = min(computeInfo.endAtRows[linearIndex], ${u}u);\n let is = &results.i[linearIndex];\n let js = &results.j[linearIndex];\n let distances = &results.distances[linearIndex];\n results.found[linearIndex] = 0; // initialize the found counter\n var found: u32 = 0;\n if (results.done[linearIndex] > 0) {\n return; // if we are done, return\n }\n for (var i = 0; i < ${v}; i++) {\n if (startAtCol >= endAtCol && startAtRow >= endAtRow) {\n results.done[linearIndex] = 1;\n break;\n }\n if (found >= 100) {\n break;\n }\n let dist = combinedDistance(startAtCol, startAtRow);\n if (dist <= ${l}) {\n (*is)[found] = startAtCol;\n (*js)[found] = startAtRow;\n (*distances)[found] = dist;\n found = found + 1;\n }\n startAtCol = startAtCol + 1;\n if (startAtCol >= ${u}u) {\n startAtRow += 1;\n startAtCol = startAtRow + 1;\n }\n }\n results.found[linearIndex] = found;\n // update the startAtCols and startAtRows\n computeInfo.startAtCols[linearIndex] = startAtCol;\n computeInfo.startAtRows[linearIndex] = startAtRow;\n\n }\n\n // this will generate the distance script for each distance metric and then combine them into one\n ${se(n,h.map((e=>e.maxEntryLen)),l,s)}\n\n\n `}),I=o.createComputePipeline({label:"sparse matrix compute pipeline",layout:"auto",compute:{module:x,entryPoint:"calcSparseMatrix"}}),M=new Uint32Array(g),N=new Uint32Array(g),$=new Uint32Array(g),L=new Uint32Array(g),P=Math.floor(A/g);let R=0,O=1;console.time("GPUthreadStarts");for(let e=0;e<g;e++){const t=9999===e?A-1:(e+1)*P,n=u-2-Math.floor(Math.sqrt(-8*t+4*u*(u-1)-7)/2-.5),s=t-u*n+Math.floor((n+1)*(n+2)/2);M[e]=O,N[e]=R,$[e]=s,L[e]=n,R=n,O=s}console.timeEnd("GPUthreadStarts");const k=4e4+u*c+c+h.reduce(((e,t)=>e+t.sourceArraySize),0),D=h.reduce(((e,t)=>e+t.suppInfoSize),0),F=1e6,G=k*Uint32Array.BYTES_PER_ELEMENT;let B=G;const V=15&G;0!==V&&(B+=16-V);const U=o.createBuffer({label:"compute info buffer",size:B,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),H=U.getMappedRange();let j=0;new Uint32Array(H,j,g).set(M),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set(N),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set($),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,g).set(L),j+=g*Uint32Array.BYTES_PER_ELEMENT,new Uint32Array(H,j,f.length).set(f),j+=f.length*Uint32Array.BYTES_PER_ELEMENT,new Float32Array(H,j,c).set(r),j+=c*Float32Array.BYTES_PER_ELEMENT;for(const e of h){const t=e.EncodedArrayConstructor,n=e.sourceArraySize;new t(H,j,n).set(e.flatSourceArray),j+=n*t.BYTES_PER_ELEMENT}U.unmap();const W=D*Uint32Array.BYTES_PER_ELEMENT;let Z=W;const q=15&W;0!==q&&(Z+=16-q),Z=Math.max(Z,16);const K=o.createBuffer({label:"supp info buffer",size:Z,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC|GPUBufferUsage.COPY_DST,mappedAtCreation:!0}),z=K.getMappedRange();let J=0;for(const e of h)e.suppInfoBuffer&&e.suppInfoBuffer.byteLength>0&&e.suppInfoSize>0&&(new("UINT32ARRAY"===e.suppInfoType?Uint32Array:Float32Array)(z,J,e.suppInfoBuffer.length).set(e.suppInfoBuffer),J+=e.suppInfoBuffer.byteLength);0===J&&new Uint32Array(z,0,4).set([1,1,1,1]),K.unmap();const Q=302e4*Uint32Array.BYTES_PER_ELEMENT;let ne=Q;const re=15&Q;0!==re&&(ne+=16-re);const ie=o.createBuffer({label:"results buffer",size:ne,usage:GPUBufferUsage.STORAGE|GPUBufferUsage.COPY_SRC}),oe=o.createBindGroup({label:"bindGroup for sparse matrix buffer",layout:I.getBindGroupLayout(0),entries:[{binding:0,resource:{buffer:U}},{binding:1,resource:{buffer:K}},{binding:2,resource:{buffer:ie}}]}),ae=o.createBuffer({label:"results out buffer",size:ie.size,usage:GPUBufferUsage.MAP_READ|GPUBufferUsage.COPY_DST}),le=[],ce=[],ue=[];let he=!1;for(;!he;){const e=o.createCommandEncoder({label:"distance encoder"}),t=e.beginComputePass({label:"distance compute pass"});t.setPipeline(I),t.setBindGroup(0,oe),t.dispatchWorkgroups(w,w),t.end(),e.copyBufferToBuffer(ie,0,ae,0,ae.size);const n=e.finish();o.queue.submit([n]),yield o.queue.onSubmittedWorkDone(),yield ae.mapAsync(GPUMapMode.READ);const s=ae.getMappedRange();let r=0;const i=new Uint32Array(s,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const a=new Uint32Array(s,r,F);r+=F*Uint32Array.BYTES_PER_ELEMENT;const l=new Float32Array(s,r,F);r+=F*Float32Array.BYTES_PER_ELEMENT;const c=new Uint32Array(s,r,g);r+=g*Uint32Array.BYTES_PER_ELEMENT,he=new Uint32Array(s,r,g).every((e=>1===e));const u=c.reduce(((e,t)=>e+t),0),h=new Uint32Array(u),d=new Uint32Array(u),m=new Float32Array(u);let p=0;for(let e=0;e<c.length;e++){const t=c[e];0!==t&&(h.set(i.subarray(e*y,e*y+t),p),d.set(a.subarray(e*y,e*y+t),p),m.set(l.subarray(e*y,e*y+t),p),p+=t)}le.push(h),ce.push(d),ue.push(m),ae.unmap()}const de=le.reduce(((e,t)=>e+t.length),0),me=new Uint32Array(de),pe=new Uint32Array(de),fe=new Float32Array(de);let ge=0;for(let e=0;e<le.length;e++)me.set(le[e],ge),pe.set(ce[e],ge),fe.set(ue[e],ge),ge+=le[e].length;return U.destroy(),K.destroy(),ie.destroy(),ae.destroy(),{i:me,j:pe,distance:fe}}))}([x.entries],w,[u],Y.MANHATTAN,[1],[x.options??{}])}catch(e){console.error(e)}M||(d.useWebGPU&&console.error("WebGPU sparse matrix calculation failed, falling back to CPU implementation"),M=await(new B).calc(x.entries,u,w,x.options));const N=await async function(e,t){const n=e.distance.map(((n,s)=>{const r=Math.abs(t.get(e.i[s])-t.get(e.j[s]));return 0!=n?r/n:1/0})),s=e.distance.map((e=>1-e)),r=e.i,i=e.j,o=a.BitSet.create(t.length);return e.distance.forEach(((t,n)=>{o.set(e.i[n],!0),o.set(e.j[n],!0)})),{simVals:s,saliVals:n,n1:r,n2:i,cliffsBitSet:o}}(M,l),L=function(e,t,n,s,r,i,o){const l=new Array(e).fill(0);for(let e=0;e!=s.length;++e)n[e]!=1/0&&(o.get(s[e])>o.get(r[e])?l[s[e]]+=n[e]:l[r[e]]+=n[e]);return a.Column.fromList("double",t,l)}(t.length,`sali_${s[0].substring(s[0].lastIndexOf("_"))}`,N.saliVals,N.n1,N.n2,0,l);e.columns.add(L);const P=N.cliffsBitSet,O=function(e){const t=e.filter((e=>e!==1/0)),n=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE);return{max:t.reduce(((e,t)=>Math.max(e,t)),n),min:n}}(N.saliVals),k=.8/(O.max-O.min),D=i.shell.getTableView(e.name),F=D.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:s[0],yColumnName:s[1],size:L.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),G=function(e,t,n,s,r,i,o,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let n=0;n<t.n1.length;n++)c.from[n]=t.n1[n],c.to[n]=t.n2[n],c.opacities[n]=t.saliVals[n]===1/0?1:.2+(t.saliVals[n]-o.min)*l,c.colors[n]=e.selection.get(c.from[n])&&e.selection.get(c.to[n])?"255,255,0":"0,128,0",c.widths[n]=1;const u=a.DataFrame.create(c.from.length);return he.forEach(((e,t)=>{u.columns.addNewString(e).init((e=>n.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((n=>{e.tags[n]=t[n]}))}(u.col(e),i),u.col(e).semType=r})),u.columns.addNewFloat(ae).init((e=>Math.abs(s.get(c.from[e])-s.get(c.to[e])))),u.columns.addNewInt(ue).init((e=>e)),u.columns.addNewFloat(le).init((e=>t.saliVals[e])),u.columns.addNewFloat(ce).init((e=>t.simVals[e])),u.name=`${ie}${re}`,{lines:c,linesDf:u}}(e,N,t,l,m,p,O,k);G.lines.skipMultiLineCalculation=!0,G.linesDf.col(le).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const U=new j(F,s[0],s[1],G.lines,V.none),H=b?b(G.linesDf,he).sort([le],[!1]):G.linesDf.plot.grid().sort([le],[!1]);H.col(ue)&&(H.col(ue).visible=!1),e.temp[".cliffsDfGrid"]=H;const W=o.button(`${G.linesDf.rowCount} cliffs`,(()=>{D.dockManager.dock(H,"down",null,"Activity cliffs",v??.2)}));W.classList.add("scatter_plot_link","cliffs_grid"),F.root.append(W);const Z=o.switchInput("Show only cliffs",!1,(()=>{Z.value?(F.dataFrame.setTag(de,s[0]),e.filter.and(P),oe.next(s[0])):(F.dataFrame.setTag(de,""),e.filter.setAll(!0),oe.next(""))}));Z.root.classList.add("scatter_plot_link","show_only_cliffs"),F.root.append(Z.root),oe.subscribe((e=>{Z.enabled=""===e||e===s[0]}));let q=!1;F.onEvent("d4-before-draw-scene").subscribe((t=>{q?q=!1:Z.value&&(setTimeout((()=>{e.filter.and(P)}),100),q=!0)}));const z=i.events.onViewerClosed.subscribe((e=>{e.args.viewer===F&&(D.dockManager.close(H.root),z.unsubscribe(),D.subs=D.subs.filter((e=>e!==z)))}));return D.subs.push(z),G.linesDf.onCurrentCellChanged.subscribe((()=>{for(let e=0;e<G.linesDf.rowCount;e++)G.lines.widths[e]=e===G.linesDf.currentRowIdx?3:1;U.linesToRender=G.lines;const n=G.linesDf.currentCol&&G.linesDf.currentCol.name===he[1]?G.lines.to:G.lines.from,r=-1!==G.linesDf.currentRowIdx?G.linesDf.currentRowIdx:null;if(F.dataFrame.currentRowIdx=r?n[r]:-1,null!==r){const n=G.linesDf.currentRowIdx;U.currentLineId=n;const{zoomLeft:a,zoomRight:c,zoomTop:u,zoomBottom:h}=function(e,t,n,s,r,i){const o=Math.abs(n-r),a=Math.abs(s-i),l=e/o,c=t/a,u=Math.min(l,c),h=e/u*5,d=t/u*5,m=(n<r?n:r)+o/2-h/2,p=(s>i?s:i)-a/2+d/2;return{zoomLeft:m,zoomRight:m+h,zoomTop:p,zoomBottom:p-d}}(F.viewport.width,F.viewport.height,F.dataFrame.get(s[0],G.lines.from[n]),F.dataFrame.get(s[1],G.lines.from[n]),F.dataFrame.get(s[0],G.lines.to[n]),F.dataFrame.get(s[1],G.lines.to[n]));F.zoom(a,u,c,h),Z.value?e.filter.and(P):!0===Z.enabled&&e.filter.setAll(!0),setTimeout((()=>{!function(e,t,n,s,r,a,l,c,u){const h=t.getPane("Cliff Details");o.empty(h.root);const d=u({points:[n,s],lineId:r,df:e,seqCol:a,activityCol:l,sali:c});h.root.append(d),setTimeout((()=>{i.shell.o=t.root}),500)}(e,C,G.lines.from[r],G.lines.to[r],r,t,l,G.linesDf.get(le,r),y);const n=F.dataFrame.getSortedOrder(D.grid.sortByColumns,D.grid.sortTypes);D.grid.scrollToCell(t.name,n.indexOf(F.dataFrame.currentRowIdx))}),1e3)}})),G.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<G.linesDf.rowCount;e++){const n=G.linesDf.selection.get(e);n&&(t.set(G.lines.from[e],!0),t.set(G.lines.to[e],!0)),G.lines.colors[e]=n?"255,255,0":"0,128,0"}e.selection.copyFrom(t),U.linesToRender=G.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(A?A=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<G.lines.colors.length;e++)G.lines.colors[e]="0,128,0";U.linesToRender=G.lines})(H.dataFrame))})),U.lineClicked.subscribe((t=>{if(A=!0,U.currentLineId=t.id,-1!==t.id){const n=G.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(n.set(t.id,!n.get(t.id)),G.linesDf.selection.copyFrom(n)):(G.linesDf.currentRowIdx!==t.id&&(G.linesDf.currentRowIdx=t.id,e.currentRowIdx=G.lines.from[t.id]),G.linesDf.selection.copyFrom(n));const s=G.linesDf.getSortedOrder(H.sortByColumns,H.sortTypes);H.scrollToCell(he[0],s.indexOf(t.id))}),500)}})),U.lineHover.pipe((0,R.debounceTime)(500)).subscribe((n=>{-1!==n.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(g({lineId:n.id,points:[G.lines.from[n.id],G.lines.to[n.id]],df:e,seqCol:t,activityCol:l}),n.x,n.y)})),F.addProperty("similarityLimit","double",w),C=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),i.shell.o=e.root,e}(),F}var pe,fe=n(8447),ge=n(8607),ye=n(5226),be=n(7228),ve=n(8457);async function we(e,t,n,s){const r=(0,ve.O)(t),i=ge.g.forColumn(t).getNewColumnFromList("ref",[n]),o=ge.g.forColumn(i).getSplitted(0),l=s===pe.IDENTITY?function(e,t){const n=t.columns.length,s=new Array(n),r=new Array(n),i=new Array(n);for(let o=0;o<n;++o){const n=t.columns.byIndex(o);s[o]=n.getRawData(),r[o]=n.categories.indexOf(""),i[o]=n.categories.indexOf(e.getOriginal(o)??"")}const o=a.Column.float("Identity",t.rowCount),l=o.getRawData();for(let n=0;n<t.rowCount;++n){l[n]=0;for(let t=0;t<e.length;++t)s[t][n]===i[t]&&++l[n];l[n]/=e.length}return o}(o,r):s===pe.SIMILARITY?await async function(e,t){const n=t.columns.toList();return await(0,be.Qx)(n,e)}(o,r):null;if(null===l)throw new Error(`In bio library: Unkown sequence scoring method: ${s}`);return l.name=e.columns.getUnusedName(l.name),e.columns.add(l),l}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(pe||(pe={}));var Ce=n(7945),Ae=n(4293),Se=n(6414),xe=n.n(Se),Ee=n(8260);const Te="#808080",_e="rgb(0,0,0)",Ie=Ee.GU;var Me,Ne;!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(Me||(Me={})),function(e){e.MSA="MSA",e.classic="classic"}(Ne||(Ne={}));const $e=new class{constructor(){this.color="rgb(100,100,100)",this.pivot=0,this.left=!1,this.transparencyRate=1,this.separator="",this.last=!1,this.drawStyle=Ne.classic,this.maxWord=[],this.wordIdx=0,this.gridCell=null,this.referenceSequence=null,this.maxLengthOfMonomer=null,this.monomerTextSizeMap={},this.logger=void 0}};function Le(e,t,n,s,r,i,o){var a,l,c;const u=Object.assign(Object.assign({},$e),o);o.logger?.debug("Bio: printLeftOrCentered(), start"),e.textAlign="start";let h=t.substring(0),d=u.last?"":u.separator;u.drawStyle===Ne.MSA&&(d="");let m=!0,p=!0,f="difference";if(null!=u.gridCell&&null!=u.gridCell.cell.column&&(m=u.gridCell.cell.column.temp["color-code"]??!0,p=u.gridCell.cell.column.temp["compare-with-current"]??!0,f=u.gridCell.cell.column.temp["highlight-difference"]??"difference"),u.referenceSequence){const e=u.referenceSequence[u.wordIdx];p&&u.referenceSequence.length>0&&"difference"===f&&(u.transparencyRate=h==e?.3:u.transparencyRate),p&&u.referenceSequence.length>0&&"equal"===f&&(u.transparencyRate=h!=e?.3:u.transparencyRate)}null!=u.maxLengthOfMonomer&&(h=Ie(h,u.maxLengthOfMonomer));const g=h+d;(a=u.monomerTextSizeMap)[g]??(a[g]=e.measureText(g));let y=u.monomerTextSizeMap[g];(l=u.monomerTextSizeMap)[h]??(l[h]=e.measureText(h));let b=u.monomerTextSizeMap[h].width;const v=i/2-(y.fontBoundingBoxAscent+y.fontBoundingBoxDescent)/2+1;(c=u.monomerTextSizeMap)[d]??(c[d]=e.measureText(d));const w=u.monomerTextSizeMap[d].width;function C(t,r){const i=m?u.color:_e;e.fillStyle=i,e.globalAlpha=u.transparencyRate,u.drawStyle===Ne.classic&&(e.fillText(h,n+t,s+v),e.fillStyle=Te,e.fillText(d,n+r,s+v)),u.drawStyle===Ne.MSA&&e.fillText(h,n+t,s+v)}y=y.width,u.drawStyle===Ne.MSA&&(b=u.maxWord[u.wordIdx],y=u.maxWord[u.wordIdx]);const A=(u.maxWord[u.wordIdx]??0)-(u.maxWord[0]??0);if(u.left||y>r)return C(A,A+b),n+A+b+w;{const e=(r-y)/2;return C(e,e+b),n+A+e+b}}var Pe=n(9611),Re=n(7331);const Oe={[fe.fb.DNA]:"RNA",[fe.fb.RNA]:"RNA",[fe.fb.PT]:"PEPTIDE",[fe.fb.UN]:"PEPTIDE"};var ke=n(9713);const De={true:"1",false:"0"};var Fe=n(3553);const Ge="rgb(100,100,100)",Be=fe.GU;function Ve(e,t,n,s,r){return e?Math.max(Math.min(e.canvas.width/r-n,s)):Math.max(t.canvas.width/r-n,0)}function Ue(e){const t=!xe().enumerate(e).some((([t,n])=>t.length>1&&0!=n&&n!=e.length-1)),n=[],s=t?"":" ";for(const[t,r]of xe().enumerate(e)){let i=t;r<e.length&&(i+=`${t?"":"-"}${s}`),n.push(i)}return[n,t]}class He extends a.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const[n,s,r]=(0,ke.N)(e),i=r.rendererBack;if(!i)return;const a=e.bounds,l=t.offsetX-e.gridColumn.left+(e.gridColumn.left-a.x),c=i.getPosition(e.tableRowIndex,l,a.width),u=ge.g.forColumn(s).getSplitted(e.tableRowIndex).canonicals;if(null!==c&&c<u.length){const e=u[c],n=[];let r=i._monomerStructureMap[e];r=i._monomerStructureMap[e]=(()=>{const t=ge.g.forColumn(s).alphabet??fe.fb.UN,n=Oe[t],r=bs();return r?r.getTooltip(n,e):o.divText("Monomer library is not available")})(),n.push(r),o.tooltip.show(o.divV(n),t.x+16,t.y+16)}else o.tooltip.hide()}render(e,t,n,s,r,i,o){const l=window.devicePixelRatio,[c,u,h]=(0,ke.N)(i);if(!u)return;const d=u.temp;let m=0,p=(us.properties?us.properties.MaxMonomerLength:4)??50;if(Me.maxMonomerLength in u.tags){const e=parseInt(u.getTag(Me.maxMonomerLength));p=!isNaN(e)&&e?e:50}if(".mm.cellRenderer.maxMonomerLength"in d){const e=d[".mm.cellRenderer.maxMonomerLength"];p=!isNaN(e)&&e?e:50}const[f,g,y]=(0,ke.N)(i);let b=y.rendererBack;b||(b=y.rendererBack=new Pe.A(c,u,us.logger,p,(()=>{const e=ge.g.forColumn(u);return{seqHandler:e,monomerCharWidth:7,separatorWidth:e.isMsa()?8:m,monomerToShort:Be}}))),e.save();try{u.temp[".mm.cellRenderer.settingsChanged"]!==De.true&&b.monomerLengthLimit==p||(m=d[".mm.cellRenderer.gapLength"]??m,b.setMonomerLengthLimit(p),b.setSeparatorWidth(b.isMsa()?8:m),u.temp[".mm.cellRenderer.settingsChanged"]=De.false);const[o,h]=b.getCellMonomerLengths(i.tableRowIndex,s),f=(o.length,i.cell.value,i.cell.rowIndex),g=u.getTag(fe.DX.alphabet),y=50;s=Ve(c?.grid,e,t,s,l),e.beginPath(),e.rect(t+this.padding,n+this.padding,s-this.padding-1,r-2*this.padding),e.clip(),e.font="12px monospace",e.textBaseline="top";const v=u.getTag(a.TAGS.UNITS),w=u.getTag(fe.DX.aligned),C=(0,fe.py)(g),A=u.getTag(fe.DX.separator)??"",S=b.props.separatorWidth+1*b.props.monomerCharWidth,x=Math.ceil(s/S),E=ge.g.forColumn(u),T=d["reference-sequence"],_=d["current-word"];_&&-1===u?.dataFrame?.currentRowIdx&&(d["current-word"]=null);const I=(()=>{const e=E.getSplitter(x);return xe()(e(null!=T&&""!=T?T:_??"").originals).toArray()})(),M=E.getSplitted(f);let N=Ge,$=Ne.classic;w&&w.includes("MSA")&&v==fe.r2.SEPARATOR&&($=Ne.MSA);const L=Math.min(M.length,x);for(let o=0;o<L;++o){const a=M.getOriginal(o);N=C.get(a),e.fillStyle=Ge;const l={color:N,pivot:0,left:!0,transparencyRate:1,separator:A,last:o===M.length-1,drawStyle:$,maxWord:h,wordIdx:o,gridCell:i,referenceSequence:I,maxLengthOfMonomer:p,monomerTextSizeMap:b._monomerLengthMap,logger:us.logger};if(Le(e,a,t+this.padding,n,s,r,l),y>s)break}}catch(e){const[t,n]=(0,Ce.yf)(e);b.logger.error(t,void 0,n),b.errors.push(e)}finally{e.restore()}}}class je extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return Fe.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,n,s,r,i,o){const l=window.devicePixelRatio,c=i.grid,u=i.cell,h=i.tableColumn,d=u.value??"",m=h.tags[fe.DX.separator],p=h.tags[a.TAGS.UNITS];s=Ve(c,e,t,s,l);const[f,g]=d.split("#"),y=(0,Ee.vU)(p,m);We(e,t,n,s,r,xe()(y(f).canonicals).toArray(),xe()(y(g).canonicals).toArray(),p)}}function We(e,t,n,s,r,i,o,a,l,c){if(i.length!==o.length){const e=function(e,t){let n=0,s=0;const r=e.length>t.length?e:t,i=e.length>t.length?t:e;for(let e=0;e<i.length;e++)r[e]===i[e]&&n++;const o=r.length-i.length;for(let e=r.length-1;e>o;e--)r[e]===i[e-o]&&s++;const a=new Array(Math.abs(e.length-t.length)).fill(ge.lh[fe.r2.FASTA]);function l(e){return n>s?e.concat(a):a.concat(e)}return e.length>t.length?t=l(xe()(t).toArray()):e=l(xe()(e).toArray()),{subParts1:e,subParts2:t}}(i,o);i=e.subParts1,o=e.subParts2}const u=e.measureText(Ue(i).join("")),h=e.measureText(Ue(o).join("")),d=Math.max(u.width,h.width);l&&(s=d+4*i.length,e.canvas.width=d+4*i.length);let m=Math.max(t,t+(s-(d+4*i.length))/2)+5;const p=Math.max(n,n+(r-28)/2);e.save(),e.beginPath(),e.rect(t,n,l?d+4*i.length:s,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=Re.UE.Color;"HELM"!=a&&(f=(0,fe.py)(a.substring(a.length-2)));for(let t=0;t<i.length;t++){const n=i[t],a=o[t],l=f.get(n);if(n!=a){const i=f.get(a),o=Le(e,n,m,p-7,s,r,{color:l,pivot:0,left:!0}),u=Le(e,a,m,p+7,s,r,{color:i,pivot:0,left:!0});m=Math.max(u,o),c&&(c[t]=Ye(n,a,l,i,p,7,r))}else m=Le(e,n,m,p,s,r,{color:l,pivot:0,left:!0,transparencyRate:.5});m+=4}e.restore()}function Ye(e,t,n,s,r,i,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(Ue([e]).join("")).width,u=l.measureText(Ue([t]).join("")).width,h=Math.max(c,u);return a.height=o,a.width=h+4,l.font="12px monospace",l.textBaseline="top",Le(l,e,0,r-i,h,o,{color:n,pivot:0,left:!0}),Le(l,t,0,r+i,h,o,{color:s,pivot:0,left:!0}),a}var Ze,qe=n(2997),Ke=n(9298);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(Ze||(Ze={}));const ze=new class{constructor(){this.regionTypes=[Ze.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=Ke.ES.Entropy,this.filterSource=Ke.vS.filterSource}};var Xe=n(172),Je=n(8415);const Qe=Ze;var et,tt;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(et||(et={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(tt||(tt={}));const nt=ze;class st extends a.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewerId=++st.viewerCounter,this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this._onRendered=new u.Subject,this.skipEmptyPositions=this.bool(tt.skipEmptyPositions,nt.skipEmptyPositions,{category:et.DATA}),this.regionTypes=this.stringList(tt.regionTypes,nt.regionTypes,{category:et.DATA,choices:Object.values(Qe).filter((e=>e!=Qe.Unknown))}),this.chains=this.stringList(tt.chains,nt.chains,{category:et.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(tt.fitWidth,nt.fitWidth,{category:et.LAYOUT}),this.positionWidth=this.float(tt.positionWidth,nt.positionWidth,{category:et.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(tt.positionHeight,nt.positionHeight,{category:et.LAYOUT,choices:Object.keys(Ke.ES)}),this.filterSource=this.string(tt.filterSource,nt.filterSource,{category:et.BEHAVIOR,choices:Object.values(Ke.Ct)}),this.viewSyncer=new Xe.c(us.logger)}viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case tt.regionTypes:case tt.chains:this.setData(this.regions)}switch(e.name){case tt.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[Je.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case tt.fitWidth:case tt.positionWidth:this.calcSize();break;case tt.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[Je.bo.positionHeight]:this.positionHeight});this.calcSize();break;case tt.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;us.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}async destroyView(e){us.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&o.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){us.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),n=Array.from(new Set(t.map((e=>e.order)))).sort(),s=[];for(let e=0;e<n.length;e++)for(const r of this.chains){const i=t.find((t=>t.order==n[e]&&t.chain==r));s.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:i.sequenceColumnName,startPositionName:i.positionStartName,endPositionName:i.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(s);this.logos=new Array(n.length);for(let e=0;e<n.length;++e)this.logos[e]={};for(const[e,t,n]of r)this.logos[e][t]=n,this.viewSubs.push(n.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=o.table(this.chains,(e=>[...n.length>0?[o.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(n.length).keys()].map((t=>{const n=this.logos[t][e];return n.root.style.height="100%",o.div([n.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(n.length).keys()].map((e=>t.find((t=>t.order==n[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=o.choiceInput("Data source",this.filterSource,Object.values(Ke.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=o.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),us.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){us.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let n=0;n<this.logos.length;n++){for(const t of this.chains)this.logos[n][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[n][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,n=13,s=9,r=(this.root.clientWidth-e-(this.logos.length-1)*s-n)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const n=this.logos[e][t];n.setOptions({[Je.bo.positionWidth]:r-n.positionMarginValue}),n.root.style.width=r*n.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[Je.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(tt.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const n=this.chains[t];this.logos[e][n].setOptions({[Je.bo.filterSource]:this.filterSource})}}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,qe.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}st.viewerCounter=-1;var rt=n(9017),it=n(708);async function ot(e,t,n="Morgan"){const s=e.length,r=ge.g.forColumn(e),i=Array(s);let o=1;const a=new Map,l=e.categories,c=e.getRawData();for(let t=0;t<s;t++){if(null===l[c[t]]||e.isNone(t)){i[t]=null;continue}i[t]="";const n=r.getSplitted(t);for(let e=0;e<n.length;e++){const s=n.getCanonical(e);a.has(s)||(a.set(s,String.fromCharCode(o)),o++),i[t]+=a.get(s)}}let u={};if(t===it.U.MONOMER_CHEMICAL_DISTANCE||t===it.U.NEEDLEMANN_WUNSCH){const e=Array.from(a.keys()),t=await(0,be.GR)(e,n),s={};Object.entries(t.alphabetIndexes).forEach((([e,t])=>{s[a.get(e)]=t})),u={scoringMatrix:t.scoringMatrix,alphabetIndexes:s}}return{seqList:i,options:u}}var at=n(6361),lt=n(7983);function ct(e){const t=o.divH([],{style:{gap:"10px"}}),n=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return n.style.fontWeight="bold",n.style.display="flex",n.style.justifyContent="space-between",t.append(n),e.points.forEach((n=>{const s=o.divText(e.activityCol.get(n).toFixed(2));s.style.display="flex",s.style.justifyContent="left",s.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(n)),s]))})),t}function ut(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const n=new Array(2);e.points.forEach(((t,s)=>{n[s]=e.activityCol.get(t)}));const s={},r=ge.g.forColumn(e.seqCol),i=dt(r.getSplitted(e.points[0]),r.getSplitted(e.points[1]),r.units,s);return t.append(o.div(i,{style:{width:"300px",overflow:"scroll"}})),t.append(mt(s)),t.append(ht("Activity delta",Math.abs(n[0]-n[1]))),t.append(ht("Cliff",e.sali)),t}function ht(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function dt(e,t,n,s){const r=document.createElement("canvas"),i=r.getContext("2d");return r.height=30,We(i,0,0,0,30,xe()(e.canonicals).toArray(),xe()(t.canonicals).toArray(),n,!0,s),r}function mt(e){const t=o.div();if(Object.keys(e).length>0){const n=o.divV([]);n.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",n.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(n)}return t}function pt(e,t){const n=a.Column.string("seq_diff",e.rowCount).init((n=>`${e.get(t[0],n)}#${e.get(t[1],n)}`));n.semType="MacromoleculeDifference",n.setTag(a.TAGS.UNITS,e.col(t[0]).getTag(a.TAGS.UNITS)),n.setTag(fe.DX.separator,e.col(t[0]).getTag(fe.DX.separator)),e.columns.add(n);const s=e.plot.grid();return s.col(t[0]).visible=!1,s.col(t[1]).visible=!1,s}class ft extends a.JsViewer{constructor(e){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[a.TAGS.UNITS,fe.DX.aligned,fe.DX.separator,fe.DX.alphabet],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",O.kg[0],{choices:O.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(o.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var gt=n(7241),yt=n(1821);const bt={gapPenalty:1,matchScore:1,gapSymbol:ge.lh[yt.r2.FASTA],localAlignment:!1};class vt extends ft{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new u.Subject,this.distanceMatrixComputed=!1,this.kPrevNeighbors=0,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(e){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,e&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const e=ge.g.forColumn(this.moleculeColumn);await(e.isHelm()?this.computeByChem():this.computeByMM());const t=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=a.Column.string(t,this.idxs.length).init((e=>this.moleculeColumn?.get(this.idxs?.get(e)))),this.molCol.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>this.molCol.setTag(e,this.moleculeColumn.getTag(e))));const n=a.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);n.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=n.col("indexes").get(n.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(n)}),1e3),this.gridSelect=!0}));const s=n.plot.grid();s.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((e=>e==this.targetMoleculeIdx));s.cell("score",r).cell.value=null,i.shell.v.grid.root.addEventListener("click",(e=>{this.gridSelect=!1})),(0,Ae.Y)(this.root,s.root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,gt.D)(this.moleculeColumn),t=(a.DataFrame.fromColumns([e]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:e,molecule:e.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=t.getCol("indexes"),this.scores=t.getCol("score")}async computeByMM(){const e=this.moleculeColumn.length,t=Math.min(this.limit,e-1);if(!this.knn||this.kPrevNeighbors!==t){const n=(await ot(this.moleculeColumn,it.U.LEVENSHTEIN)).seqList;this.kPrevNeighbors=t,this.knn=await(new B).getKNN(n,it.U.LEVENSHTEIN,Math.min(this.limit,e-1))}const n=new Array(t).fill(0).map(((e,t)=>({idx:this.knn.knnIndexes[this.targetMoleculeIdx][t],score:1-this.knn.knnDistances[this.targetMoleculeIdx][t]})));n.sort(((e,t)=>t.score-e.score)),n.unshift({idx:this.targetMoleculeIdx,score:a.FLOAT_NULL}),this.idxs=a.Column.int("indexes",t+1).init((e=>n[e].idx)),this.scores=a.Column.float("score",t+1).init((e=>n[e].score))}createPropertyPanel(e){const t=o.div(),n={},s=this.molCol?.name,r=e.col(s),a=ge.g.forColumn(this.moleculeColumn),l=ge.g.forColumn(r),c=a.getSplitted(this.targetMoleculeIdx),u=l.getSplitted(e.currentRowIdx),h=function(e,t,n={}){const s={...bt,...n},r=e.length,i=t.length,o=Array(r+1).fill(0).map((()=>Array(i+1).fill(0)));let a=-9999,l=[1,1];for(let n=1;n<r+1;n++)for(let r=1;r<i+1;r++)o[n][r]=Math.max(0,o[n-1][r-1]+(e.getCanonical(n-1)===t.getCanonical(r-1)?s.matchScore:-s.matchScore),o[n-1][r]-s.gapPenalty,o[n][r-1]-s.gapPenalty),o[n][r]>=a&&(a=o[n][r],l=[n,r]);let c=s.localAlignment?l[0]:r,u=s.localAlignment?l[1]:i,h=new Array(0),d=new Array(0);for(;c>0&&u>0;){const n=Math.max(o[c-1][u-1],o[c-1][u],o[c][u-1]);o[c][u]==o[c-1][u-1]+s.matchScore&&n==o[c-1][u-1]?(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1):o[c][u]==o[c-1][u]-s.gapPenalty?(d.push(s.gapSymbol),h.push(e.getCanonical(c-1)),c-=1):o[c][u]==o[c][u-1]-s.gapPenalty?(h.push(s.gapSymbol),d.push(t.getCanonical(u-1)),u-=1):(h.push(e.getCanonical(c-1)),d.push(t.getCanonical(u-1)),c-=1,u-=1)}h=[...Array.from(e.canonicals).splice(0,c),...h.reverse(),...s.localAlignment?Array.from(e.canonicals).splice(l[0],r):[]],d=[...Array.from(t.canonicals).splice(0,u),...d.reverse(),...s.localAlignment?Array.from(t.canonicals).splice(l[1],i):[]];const m=c,p=u;return m>p?d=[...new Array(m-p).fill(s.gapSymbol.valueOf()),...d]:h=[...new Array(p-m).fill(s.gapSymbol.valueOf()),...h],d.length>h.length?h.push(...new Array(d.length-h.length).fill(s.gapSymbol.valueOf())):d.push(...new Array(h.length-d.length).fill(s.gapSymbol.valueOf())),{seq1:h.join(""),seq2:d.join(""),seq1Splitted:new Ee.wx(h,s.gapSymbol),seq2Splitted:new Ee.wx(d,s.gapSymbol)}}(c,u),d=dt(h.seq1Splitted,h.seq2Splitted,l.units,n);t.append(o.div(d,{style:{width:"300px",overflow:"scroll"}})),c.length!==u.length&&t.append(o.divV([o.divText("Different sequence length:",{style:{fontWeight:"bold"}}),o.divText(`target: ${c.length} monomers`),o.divText(`selected: ${u.length} monomers`)],{style:{paddingBottom:"10px"}})),t.append(mt(n));const m=o.accordion(),p=o.element("i");p.className="grok-icon svg-icon svg-view-layout",m.addTitle(o.span([p,o.label("Similarity search")])),m.addPane("Differences",(()=>t),!0),i.shell.o=m.root}}var wt=n(279);class Ct extends ft{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new u.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(e){if(this.beforeRender()&&this.dataFrame&&e&&this.moleculeColumn){const e=ge.g.forColumn(this.moleculeColumn);await(e.isFasta()?this.computeByMM():this.computeByChem());const t=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,n=a.Column.string(t,this.renderMolIds.length).init((e=>this.moleculeColumn?.get(this.renderMolIds[e])));n.semType=a.SEMTYPE.MACROMOLECULE,this.tags.forEach((e=>n.setTag(e,this.moleculeColumn.getTag(e))));const s=a.DataFrame.fromColumns([n]);s.onCurrentRowChanged.subscribe((e=>{this.dataFrame.currentRowIdx=this.renderMolIds[s.currentRowIdx]})),(0,Ae.Y)(this.root,s.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const e=await(0,gt.D)(this.moleculeColumn);a.DataFrame.fromColumns([e]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:e,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const e=(await ot(this.moleculeColumn,it.U.LEVENSHTEIN)).seqList,t=new G(!0,!1),n=await t.calc(e,it.U.LEVENSHTEIN);t.terminate();const s=this.moleculeColumn.length,r=(0,F.y)(s);this.renderMolIds=(0,wt.L)(s,Math.min(s,this.limit),((e,t)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(t)?0:n[r(e,t)]))}}var At,St=n(4004),xt=n(9943),Et=n(5393),Tt=n(6584);!function(e){e.TYPE="V2000",e[e.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",e[e.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",e[e.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",e[e.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",e[e.BOND_TYPE_COL=3]="BOND_TYPE_COL",e[e.RGP_SHIFT=8]="RGP_SHIFT",e[e.MAX_ATOM_COUNT=999]="MAX_ATOM_COUNT",e.RGP_LINE_START="M RGP",e.ATOM_ALIAS_LINE_START="A ",e.END="M END"}(At||(At={}));class _t{constructor(e){this.init(e)}init(e){this.fileContent=e.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var e;return null!==(e=this.xyzAtomCoordinates)&&void 0!==e||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var e;return null!==(e=this._atomTypes)&&void 0!==e||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var e;return null!==(e=this._pairsOfBondedAtoms)&&void 0!==e||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var e;return null!==(e=this._bondTypes)&&void 0!==e||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:e,bondCount:t}=this.parseAtomAndBondCounts();this._atomCount=e,this._bondCount=t}getNextColumnIdx(e){for(;!this.isWhitespace(e);)++e;for(;this.isWhitespace(e);)++e;return e}shiftIdxToSpecifiedColumn(e,t){let n=e;const s=this.isWhitespace(n)?t:t-1;for(let e=0;e<s;e++)n=this.getNextColumnIdx(n);return n}parseAtomTypes(){const e=this.atomCount,t=new Array(e);let n=this.getAtomBlockIdx();for(let s=0;s<e;s++)n=this.shiftIdxToAtomType(n),t[s]=this.parseAtomType(n),n=this.getNextLineIdx(n);return t}parseAtomCoordinates(){const e=new Float32Array(this.atomCount),t=new Float32Array(this.atomCount),n=new Float32Array(this.atomCount);let s=this.getAtomBlockIdx();for(let r=0;r<this.atomCount;r++){s=this.shiftIdxToXColumn(s);for(const i of[e,t,n])i[r]=this.parseFloatValue(s),s=this.getNextColumnIdx(s);s=this.getNextLineIdx(s)}return{x:e,y:t,z:n}}parseBondedAtomPairs(){const e=new Array(this.bondCount);let t=this.getBondBlockIdx();for(let n=0;n<this.bondCount;n++){t=this.shiftIdxToBondedAtomsPair(t);const s=new Uint16Array(2);s[0]=this.parseIntValue(t),t=this.getNextColumnIdx(t),s[1]=this.parseIntValue(t),e[n]=s,t=this.getNextLineIdx(t)}return e}parseBondTypes(){const e=this.bondCount,t=new Uint16Array(e);let n=this.getBondBlockIdx();for(let s=0;s<e;s++)n=this.shiftIdxToBondType(n),t[s]=this.parseIntValue(n),n=this.getNextLineIdx(n);return t}isWhitespace(e){const t=this.fileContent[e];return" "===t||"\t"===t}getNextLineIdx(e){return"\n"!==this.fileContent[e]?this.fileContent.indexOf("\n",e)+1:e+1}parseFloatValue(e){return this.parseNumericValue(parseFloat,e)}parseIntValue(e){return this.parseNumericValue(parseInt,e)}parseNumericValue(e,t){let n=t+1;for(;!this.isWhitespace(n);)++n;return e(this.fileContent.substring(t,n))}}class It extends _t{constructor(e){super(e),this.init(e)}init(e){super.init(e)}parseAtomType(e){let t=e,n=t;return this.isQuote(t)?(n=this.getNextIdenticalChar(t),t++):n=this.fileContent.indexOf(" ",n),this.fileContent.substring(t,n)}isQuote(e){const t=this.fileContent[e].charCodeAt(0);return 39===t||34===t}getNextIdenticalChar(e){const t=this.fileContent[e];return t?this.fileContent.indexOf(t,e+1):-1}isQuery(){return this.isQueryOrFragment(((e,t)=>{return 39===e||34===e||76===e&&!((n=this.fileContent.charCodeAt(t+1))>64&&n<91||n>96&&n<123);var n}))}isFragment(){return this.isQueryOrFragment((e=>82===e||42===e))}isQueryOrFragment(e){const t=this.atomCount;let n=this.getAtomBlockIdx();for(let s=0;s<t;s++){if(n=this.shiftIdxToAtomType(n),e(this.fileContent.charCodeAt(n),n))return!0;n=this.getNextLineIdx(n)}return!1}}class Mt extends It{constructor(e){super(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map,t=this.fileContent.split("\n");t.filter((e=>e.startsWith(At.RGP_LINE_START))).forEach((t=>{const n=this.getAtomIdxToRgpIdxList(t);for(const[t,s]of n){if(e.has(t))throw new Error(`R group ${t} is already in the map`);e.set(t,s)}}));const n=t.map(((e,t)=>{if(e.startsWith(At.ATOM_ALIAS_LINE_START))return t})).filter((e=>void 0!==e)),s=n.map((e=>t[e])),r=n.map((e=>t[e+1]));s.forEach(((t,n)=>{const s=parseInt(t.split(/\s+/)[1])-1,i=parseInt(r[n].substring(1));if(e.has(i))throw new Error(`R group ${i} is already in the map`);e.set(i,s)}));const i=this.getRGroupAtomicIndices().filter((t=>!Array.from(e.values()).includes(t)));if(0!==i.length)throw new Error(`Unaccounted R group indices: ${i}`);return e}getAtomIdxToRgpIdxList(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),n=new Array(t.length/2);for(let e=0;e<t.length;e+=2)n[e/2]=[t[e+1],t[e]-1];return n}getRGroupAtomicIndices(){return this.atomTypes.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}static isValidMolfile(e){return-1!==e.indexOf(At.TYPE)&&-1!==e.indexOf(At.END)}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,At.ATOM_TYPE_COL)}getCountsLineIdx(){let e=0;for(let t=0;t<At.NUM_OF_HEADER_LINES;++t)e=this.getNextLineIdx(e);return e}getAtomBlockIdx(){let e=this.getCountsLineIdx();return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){return this.getNextColumnIdx(e)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,At.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,At.BOND_TYPE_COL)}getBondBlockIdx(){let e=this.getAtomBlockIdx();for(let t=0;t<this.atomCount;t++)e=this.getNextLineIdx(e);return e}parseAtomAndBondCounts(){let e=this.getCountsLineIdx(),t=e+At.NUM_OF_COUNTS_DIGITS;const n=parseInt(this.fileContent.substring(e,t));return e=t,t+=At.NUM_OF_COUNTS_DIGITS,{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class Nt extends It{constructor(e){super(e),this.init(e)}getAtomLines(){const e=this.getAtomBlockIdx(),t=this.getBondBlockIdx();return this.fileContent.substring(e,t).split("\n").slice(0,this.atomCount)}getBondLines(){const e=this.getBondBlockIdx();return this.fileContent.substring(e).split("\n").slice(0,this.bondCount)}getRGroupIdToAtomicIdxMap(){const e=new Map;return this.getAtomLines().forEach(((t,n)=>{const s=t.match(/RGROUPS=\(([\d\s]+)\)/);if(s){const t=s[1].split(/\s+/).map((e=>parseInt(e)));if(t.length>2)throw new Error(`R group data ${t} has more than 2 elements`);const r=t[1];if(e.has(r))throw new Error(`R group ${r} is already in the map`);e.set(r,n)}})),e}shiftIdxToAtomType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let e=this.fileContent.indexOf("M V30 BEGIN ATOM");return e=this.getNextLineIdx(e),e}shiftIdxToXColumn(e){let t=this.shiftIdxToAtomType(e);return this.isQuote(t)?(t=this.getNextIdenticalChar(t),t=this.getNextColumnIdx(t),t):this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondedAtomsPair(e){return this.shiftIdxToSpecifiedColumn(e,5)}shiftIdxToBondType(e){return this.shiftIdxToSpecifiedColumn(e,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static isValidMolfile(e){return-1!==e.indexOf("V3000")&&-1!==e.indexOf("M END")}parseAtomAndBondCounts(){let e=this.fileContent.indexOf("M V30 COUNTS ")+14,t=this.fileContent.indexOf(" ",e+1);const n=parseInt(this.fileContent.substring(e,t));return e=t+1,t=this.fileContent.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(this.fileContent.substring(e,t))}}}class $t{constructor(){}static getInstance(e){if($t.isMolfileV2K(e))return new Mt(e);if($t.isMolfileV3K(e))return new Nt(e);throw new Error("Malformed molfile")}static isMolfileV2K(e){return Mt.isValidMolfile(e)}static isMolfileV3K(e){return Nt.isValidMolfile(e)}}var Lt=n(8277),Pt={};Pt.styleTagTransform=A(),Pt.setAttributes=b(),Pt.insert=g().bind(null,"head"),Pt.domAPI=p(),Pt.insertStyleElement=w(),d()(Lt.Z,Pt),Lt.Z&&Lt.Z.locals&&Lt.Z.locals;class Rt{constructor(e,t=undefined,n=undefined){this.source=t,this.error=n,this._monomers={},this._onChanged=new u.Subject,this._monomers=e;for(const[e,t]of Object.entries(this._monomers))for(const[e,n]of Object.entries(t))n.lib=this}addMissingMonomer(e,t){let n=this._monomers[e];n||(n=this._monomers[e]={});let s=t;return t===ge.lh[fe.r2.HELM]?s="Gap":("PEPTIDE"===e&&"X"===t||"RNA"===e&&"N"===t)&&(s="Any"),n[t]={symbol:t,name:s,molfile:"",author:"MISSING",id:-1,rgroups:xe().count(1).take(9).map((e=>({capGroupSmiles:"",alternateId:"",capGroupName:"",label:`R${e.toString()}`}))).toArray(),smiles:"",polymerType:e,monomerType:void 0,createDate:null}}getMonomer(e,t){let n=t;"RNA"==e&&"R"==n&&(n="r"),"RNA"==e&&"P"==n&&(n="p");let s=null;if(e){const t=this._monomers[e];s=t?t[n]:null}else{us.logger.warning(`Bio: MonomerLib.getMonomer() symbol '${t}', polymerType not specified.`);for(const[e,t]of Object.entries(this._monomers))if(s=t[n],s)break}return s}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((n=>{t[n]=this._monomers[e][n].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,n){let s=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return s=s.filter((e=>null!==e)),0===s.length?[]:(s=s.filter((t=>{if(!t?.rgroups)return!1;let n=t?.rgroups.length>=e;return $t.getInstance(t.molfile).atomTypes.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),n&&(n=!0),n})),s.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateInt(e){const t=e.getPolymerTypes(),n=this.getPolymerTypes();t.forEach((t=>{n.includes(t)||(this._monomers[t]={}),e.getMonomerSymbolsByType(t).forEach((n=>{this._monomers[t][n]=e.getMonomer(t,n)}))}))}update(e){this._updateInt(e),this._onChanged.next()}updateLibs(e,t=!1){t&&(this._monomers={});for(const t of e)t.error||this._updateInt(t);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}getSummaryObj(){const e={},t=this.getPolymerTypes();for(const n of t)e[n]=this.getMonomerSymbolsByType(n).length;return e}getSummaryDf(){const e=this.getPolymerTypes(),t=new Array(e.length);for(const[n,s]of xe().enumerate(e))t[s]=this.getMonomerSymbolsByType(n).length;return a.DataFrame.fromColumns([a.Column.fromStrings("polymerType",e),a.Column.fromList(a.COLUMN_TYPE.INT,"count",t)])}getSummary(){const e=this.getPolymerTypes();return 0==e.length?"empty":e.map((e=>`${e} ${this.getMonomerSymbolsByType(e).length}`)).join("\n")}getTooltip(e,t){const n=o.div([],{classes:"ui-form ui-tooltip"}),s=this.getMonomer(e,t);if(s){const e=s.symbol;s.name,n.append(o.divH([o.div([e],{style:{fontWeight:"bolder",textWrap:"nowrap",marginRight:"6px"}}),o.div([s.name])],{style:{display:"flex",flexDirection:"row",justifyContent:"left"}}));const t={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};let r;r=s.molfile?i.chem.svgMol(s.molfile,void 0,void 0,t):s.smiles?o.divV([i.chem.svgMol(s.smiles,void 0,void 0,t),o.divText("from smiles",{style:{fontSize:"smaller"}})]):o.divText("No structure",{style:{margin:"6px"}}),n.append(o.div(r,{style:{display:"flex",flexDirection:"row",justifyContent:"center",margin:"6px"}})),n.append(o.divText(s.lib?.source??"Missed in libraries"))}else n.append(o.divV([o.divText(`Monomer '${t}' of type '${e}' not found.`),o.divText("Open the Context Panel, then expand Manage Libraries")]));return n}}var Ot=n(5128),kt=n.n(Ot),Dt=n(3351),Ft=n.n(Dt);class Gt{constructor(e){this.helmMonomerSchema=e;const t=new(kt())({allErrors:!0,strictTuples:!1});Ft()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const n=this.parseJson(e,t);return null!==n&&(Array.isArray(n)?this.validateJsonContent(n,t):(console.warn(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format: The file must contain an array of monomers.`),!1))}parseJson(e,t){try{return JSON.parse(e)}catch(e){return console.error(`Bio: Monomer Library File Validator file '${t}': Invalid JSON format:`,e),null}}validateJsonContent(e,t){let n=!0;for(const s of e){const e=s.symbol??s.id??s.name??"#N/A";if(n=this.validateMonomerSchema(s),!n){console.warn(`Bio: Monomer Library File Validator file ${t}, monomer '${e}' violating JSON schema:`,s,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}}return n}}class Bt{constructor(e,t,n){this.fileValidator=e,this.libHelper=t,this.eventManager=n,this.filesPromise=Promise.resolve(),this.objId=++Bt.objCounter,this.eventManager.updateValidLibraryFileListRequested$.subscribe((async()=>{await this.updateValidLibraryList()}))}toLog(){return`MonomerLibFileManager<${this.objId}>`}static async create(e,t){const n=await i.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),s=JSON.parse(n),r=new Gt(s);return new Bt(r,e,t)}async addLibraryFile(e,t){try{if(await this.libraryFileExists(t))return void i.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await i.dapi.files.writeAsText(Tt.BX+`${t}`,e),await this.updateValidLibraryList(),await i.dapi.files.exists(Tt.BX+`${t}`)?i.shell.info(`Added ${t} HELM library`):i.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),i.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await i.dapi.files.delete(Tt.BX+`${e}`),await this.updateValidLibraryList(),i.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await i.dapi.files.exists(Tt.BX+`${e}`)?i.shell.error(`Failed to delete ${e} library`):i.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let n=[];const s=new a.FileSource(e),r=await s.readAsText(t);n=JSON.parse(r);const i={},o=[];return n.forEach((e=>{const t=e.polymerType,n=e.symbol;o.includes(t)||(i[t]={},o.push(t)),i[t][n]=e})),new Rt(i,t)}getValidLibraryPaths(){return this.eventManager.getValidFilesPathList()}async getValidLibraryPathsAsynchronously(){return await this.eventManager.getValidLibraryPathsAsynchronously()}async libraryFileExists(e){return await i.dapi.files.exists(Tt.BX+`${e}`)}async updateValidLibraryList(){const e=`${this.toLog()}.updateValidLibraryList()`;return us.logger.debug(`${e}, start`),this.filesPromise=this.filesPromise.then((async()=>{us.logger.debug(`${e}, IN`);const t=[],n=await this.getFilePathsAtDefaultLocation();if(!this.fileListHasChanged(n))return void us.logger.debug(`${e}, end, not changed`);for(const e of n){if(!e.endsWith(".json")){t.push(e);continue}const n=await i.dapi.files.readAsText(Tt.BX+`${e}`);this.isValidHELMLibrary(n,e)||t.push(e)}const s=n.filter((e=>!t.includes(e)));if(this.fileListHasChanged(s)&&(this.eventManager.changeValidFilesPathList(s),this.libHelper.loadLibraries(!0)),s.some((e=>!e.endsWith(".json")))&&us.logger.warning(`Wrong validation: ${s}`),t.length>0){const e=`Invalid monomer library files in ${Tt.BX}, consider fixing or removing them: ${t.join(", ")}`;us.logger.warning(e)}us.logger.debug(`${e}, OUT`)}))}fileListHasChanged(e){const t=this.eventManager.getValidFilesPathList();return e.length!==t.length||e.some(((e,n)=>e!==t[n]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.fileValidator.validateFile(e,t)}async getFilePathsAtDefaultLocation(){const e=(await i.dapi.files.list(Tt.BX)).map((e=>e.fullPath)),t=[];for(const n of e)await i.dapi.files.exists(n)&&t.push(n);return t.map((e=>e.substring(Tt.BX.length)))}}Bt.objCounter=-1;class Vt{constructor(){this._libraryFilesUpdateSubject$=new u.BehaviorSubject([]),this._addLibraryFilesSubject$=new u.Subject,this._librarySelectionSubject$=new u.Subject}static getInstance(){return Vt._instance||(Vt._instance=new Vt),Vt._instance}getValidFilesPathList(){return this._libraryFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{this._libraryFilesUpdateSubject$.pipe((0,R.skip)(1)).subscribe((t=>{e(t)}))}))}changeValidFilesPathList(e){this._libraryFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}class Ut{get eventManager(){return this._eventManager}async awaitLoaded(e=3e3){return await Promise.race([(async()=>{const e=await this.getFileManager();return await e.filesPromise,!0})(),(async()=>(await(0,qe.gw)(e),!1))()]).then((t=>{if(!t)throw new Error(`Loading monomer libraries is timeout ${e} ms.`)}))}constructor(){this._monomerLib=new Rt({},"MAIN"),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async getFileManager(){return void 0===this._fileManagerPromise&&(this._fileManagerPromise=(async()=>await Bt.create(this,this._eventManager))()),this._fileManagerPromise}async loadLibraries(e=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[t,n]=await Promise.all([(await this.getFileManager()).getValidLibraryPaths(),(0,Tt.nW)()]),s=t.filter((e=>{const t=!n.exclude.includes(e),s=0===n.explicit.length||n.explicit.includes(e);return t&&s})),r=await Promise.all(s.map((e=>this.readLibrary(Tt.BX,e).catch((t=>{const n=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new Rt({},e,n)})))));this._monomerLib.updateLibs(r,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;i.shell.warning(t);const n=e instanceof Error?e.stack:void 0;us.logger.error(t,void 0,n)}}))}async readLibrary(e,t){const n=await this.getFileManager();return await n.loadLibraryFromFile(e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const n=await(0,Tt.nW)();n.exclude=(await this.getFileManager()).getValidLibraryPaths().filter((t=>!e.includes(t))),await(0,Tt.tW)(n)}async getInvalidFileNames(e){const t=(await this.getFileManager()).getValidLibraryPaths();return e.filter((e=>!t.includes(e)))}static async getInstance(){let e=window.$monomerLibHelperPromise;return void 0===e&&(e=window.$monomerLibHelperPromise=(async()=>{const e=new Ut;return e._eventManager=Vt.getInstance(),e})()),e}}var Ht=n(3336),jt=n.n(Ht),Wt=n(8710),Yt={};async function Zt(){await zt.showDialog()}Yt.styleTagTransform=A(),Yt.setAttributes=b(),Yt.insert=g().bind(null,"head"),Yt.domAPI=p(),Yt.insertStyleElement=w(),d()(Wt.Z,Yt),Wt.Z&&Wt.Z.locals&&Wt.Z.locals;class qt{get widget(){return this._widget}constructor(){}static async getInstance(){return void 0===qt.instancePromise&&(qt.instancePromise=(async()=>{const e=new qt,t=await(0,be.JN)();return e._fileManager=await t.getFileManager(),e._widget=await e.createWidget(),e})()),qt.instancePromise}async createWidget(){const e=await this.getWidgetContent();return(await(0,be.JN)()).eventManager.addLibraryFileRequested$.subscribe((async()=>await this.promptToAddLibraryFiles())),new a.Widget(e)}async getWidgetContent(){const e=await Kt.createControlsForm();return jt()(e).addClass("monomer-lib-controls-form"),o.divV([e])}async promptToAddLibraryFiles(){a.Utils.openFile({accept:".json",open:async e=>{const t=await e.text(),n=e.name,s=a.TaskBarProgressIndicator.create(`Adding ${n} as a monomer library`);try{await this._fileManager.addLibraryFile(t,n)}catch(e){i.shell.error(`File ${n} is not a valid monomer library, verify it is aligned to HELM JSON schema.`)}finally{s.close()}}})}}class Kt{constructor(e,t){this.fileManager=e,this.userLibSettings=t,this.fileManager.eventManager.updateUIControlsRequested$.subscribe((()=>{this.updateControlsForm()})),this.fileManager.eventManager.librarySelectionRequested$.subscribe((async([e,t])=>{await this.updateLibrarySelectionStatus(t,e)}))}toLog(){return"LibraryControlsManager<#>"}static async createControlsForm(){us.logger.debug("LibraryControlsForm.createControlsForm(), start");const[e,t]=await Promise.all([(0,be.JN)().then((e=>e.getFileManager())),await(0,Tt.nW)()]);return new Kt(e,t)._createControlsForm()}_createControlsForm(){const e=this.createLibraryControls(),t=o.form(e);return jt()(t).addClass("monomer-lib-controls-form"),t}updateControlsForm(){const e=this._createControlsForm();jt()(".monomer-lib-controls-form").replaceWith(e)}createLibraryControls(){return this.fileManager.getValidLibraryPaths().map((e=>this.createLibInput(e)))}createLibInput(e){const t=`${this.toLog()}.createLibInput()`;us.logger.debug(`${t}, libFileName = '${e}', start`);const n=!this.userLibSettings.exclude.includes(e),s=o.boolInput(e,n,(t=>{this.fileManager.eventManager.updateLibrarySelectionStatus(e,t)}));o.tooltip.bind(s.root,`Include monomers from ${e}`);const r=o.iconFA("trash-alt",(()=>this.promptForLibraryDeletion(e)));return o.tooltip.bind(r,`Delete ${e}`),s.addOptions(r),us.logger.debug(`${t}, libFileName = '${e}', end`),s}async updateLibrarySelectionStatus(e,t){this.updateLibrarySettings(e,t),await(0,Tt.tW)(this.userLibSettings);const n=await(0,be.JN)();await n.loadLibraries(!0),i.shell.info("Monomer library user settings saved")}updateLibrarySettings(e,t){e?this.userLibSettings.exclude=this.userLibSettings.exclude.filter((e=>e!==t)):this.userLibSettings.exclude.includes(t)||this.userLibSettings.exclude.push(t)}promptForLibraryDeletion(e){o.dialog("Warning").add(o.divText(`Delete file ${e}?`)).onOK((async()=>{try{const t=a.TaskBarProgressIndicator.create(`Deleting ${e} library`);await this.updateLibrarySelectionStatus(!1,e),await this.fileManager.deleteLibraryFile(e),t.close()}catch(t){console.error(t),i.shell.error(`Failed to delete ${e} library`)}})).showModal(!1)}}class zt{constructor(){this.closeDialogSubject$=new u.Subject}static async showDialog(){zt._instance||(zt._instance=new zt,zt._instance.closeDialogSubject$.subscribe((()=>{zt._instance.dialog=void 0}))),zt._instance.dialog||(zt._instance.dialog=await zt._instance.getDialog()),zt._instance.dialog.show()}async getDialog(){const e=Vt.getInstance(),t=(await qt.getInstance()).widget,n=o.dialog({title:"Manage monomer libraries",helpUrl:"/help/datagrok/solutions/domains/bio/bio.md#manage-monomer-libraries"});return jt()(n.root).css("width","350px"),n.clear(),n.addButton("Add",(()=>e.addLibraryFile()),void 0,"Upload new HELM monomer library"),n.add(t),n.onClose.subscribe((()=>this.closeDialogSubject$.next())),n}}var Xt,Jt=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};class Qt{constructor(e,t,n=!1,s){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=n,this._autoStartFirstStep=null!==(r=null==s?void 0:s.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Qt.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let n=o.iconFA("clock");this._isAutomatic||0===t&&(n=o.iconFA("play",(()=>this._nextStep()),"Next step"),n.className="grok-icon fas fa-play");const s=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),i=o.divH([n,s],"grok-tutorial-entry");this._activity.append(i,r)}}_initRoot(){var e,t,n;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const s=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,s,""),(null===(t=null===(e=s.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(n=s.parent.container.containerElement.firstElementChild)||void 0===n||n.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return Jt(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const n=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],s=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];s.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const i=n,a=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,i.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(n,s,a),yield(0,qe.gw)(a));const l=o.iconFA("check");if(s.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return Jt(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,n){return Jt(this,void 0,void 0,(function*(){const s=o.div([],"demo-script-countdown");t.classList.add("hidden");let r=n/1e3;const i=this._createSVGIndicator(r);s.append(i),e.prepend(s);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),s.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),n=document.createElementNS("http://www.w3.org/2000/svg","circle");return n.setAttributeNS(null,"cx","7"),n.setAttributeNS(null,"cy","7"),n.setAttributeNS(null,"r","6"),n.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(n),t}_changeStopState(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Qt.currentObject=null}step(e,t,n){return this._steps[this.steps.length]={name:e,func:t,options:n},this}start(){return Jt(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function en(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;i.shell.error(t),us.logger.error(e.message,void 0,n)}Qt.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Xt||(Xt={}));const tn="samples/FASTA_PT_activity.csv";async function nn(){const e="Dendrogram",t=a.Func.find({package:e,name:"getTreeHelper"});if(0===t.length)throw new Error(`Package "${e}" must be installed for TreeHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}async function sn(){return await i.functions.call("Dendrogram:getDendrogramService",{})}var rn=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};function on(e,t,s){return rn(this,void 0,void 0,(function*(){return new Promise((function(r,i){const o=new Worker(new URL(n.p+n.u(356),n.b));o.postMessage({distMatArray:e,n:t,methodCode:s}),o.onmessage=({data:{error:e,clusterMatrix:t}})=>{o.terminate(),e?i(e):r(t)}}))}))}var an,ln,cn,un=function(e,t,n,s){return new(n||(n=Promise))((function(r,i){function o(e){try{l(s.next(e))}catch(e){i(e)}}function a(e){try{l(s.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof n?t:new n((function(e){e(t)}))).then(o,a)}l((s=s.apply(e,t||[])).next())}))};n(7905),function(e){e.ADD="ADD",e.SUB="SUB",e.MULT="MULT"}(an||(an={})),function(e){e.SQUARE="SQUARE",e.INVERSE="INVERSE",e.TRANSPOSE="TRANSPOSE",e.NORM="NORM",e.COLUMN_NORM="COLUMN_NORM"}(ln||(ln={})),function(e){e.SCALARMULT="SCALARMULT",e.SCALARADD="SCALARADD",e.SCALARPOW="SCALARPOW"}(cn||(cn={}));const hn="samples/FASTA_PT_activity.csv",dn="sequence";const mn="samples/FASTA_PT_activity.csv";var pn=n(8341);const fn="samples/HELM.csv";var gn=n(2568),yn=n(6098),bn=n(525);class vn{constructor(e,t,n={}){this.urlParams=e,this.funcName=t,this.options=n}async init(e){this.df=e,await this.buildView()}async buildView(){const e=xe()(this.urlParams.entries()).map((([e,t])=>`${e}=${encodeURIComponent(t)}`)).toArray().join("&");this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${us.name}.${this.funcName}?${e}`;const t={...this.options,sequenceColumnName:"sequence"};for(const[e,n]of this.urlParams.entries())switch(e){case Je.bo.fixWidth:case Je.bo.fitArea:t[e]=["1","on","true"].includes(n.toLowerCase());break;default:t[e]=n}const n=await this.view.dataFrame.plot.fromType("WebLogo",t);this.view.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class wn{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=o.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const e=this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE),t={filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE};this.seqColInput=o.columnInput("Sequence",this.tableInput.value,e,null,t),this.funcParamsDiv=o.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=o.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE))}}var Cn=n(9416);class An{constructor(e){this.monomerLib=e}getCappedRotatedMonomer(e,t){const n=this.monomerLib.getMonomer(e,t);return n?n.molfile:null}}const Sn=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},xn={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class En{constructor(e){this.gridCol=e,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(e,t,n){if(e.grid.dart!=this.gridCol.grid.dart||e.gridColumn.dart!=this.gridCol.dart||!e.tableColumn||!e.isTableCell)return!1;const s=e.tableColumn.getTag(yt.DX.alphabet),r=e.cell.value,a=e.grid.canvas.getBoundingClientRect(),l=e.bounds.right+a.left-4,c=e.bounds.bottom+a.top-4,u=bs();if(!u)return o.tooltip.show(o.divText("Monomer library is not available."),l,c),!0;const h=new An(u),d=s===fe.fb.DNA||s===fe.fb.RNA?"RNA":(fe.fb.PT,"PEPTIDE"),m=h.getCappedRotatedMonomer(d,r),p=o.div(r),f=m?i.chem.svgMol(m,void 0,void 0,xn):null;return o.tooltip.show(o.divV([p,...f?[f]:[]]),l,c),!0}static getOrCreate(e){let t=e.temp[Sn.tooltipHandlerTemp];return t||(t=e.temp[Sn.tooltipHandlerTemp]=new En(e)),t}}class Tn extends a.GridCellRenderer{get name(){return Fe.Of.MONOMER}get cellType(){return Fe.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,n,s,r,i,o){if(i.gridRow<0)return;En.getOrCreate(i.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,fe.py)(i.cell.column.getTag(yt.DX.alphabet)),l=i.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c,e.fillText((0,fe.GU)(l,6),t+s/2,n+r/2,s)}}class _n extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){const e=super.get("MaxMonomerLength");return"long"===e?null:parseInt(e)}set MaxMonomerLength(e){const t=null===e?"long":e.toString();super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(e){super.set("TooltipWebLogo",e),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(e){if(1!==e.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",e),this._onPropertyChanged.next("DefaultSeparator")}constructor(e){super(Object.entries(e)),this._onPropertyChanged=new u.Subject}}class In extends a.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(e){this._properties=e}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(e){const[t,n]=(0,Ce.yf)(e);i.shell.error(t),this.logger.error(t,void 0,n)}}var Mn=n(8770);class Nn extends a.Widget{constructor(e){super(o.divV([])),this.viewed=!1,this.wlViewer=null,this.seqCol=e}async init(){const e=ge.g.forColumn(this.seqCol),t=us.properties.TooltipWebLogo,n=this.seqCol.getTag(Ke.DX.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(n)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1,positionNames:"",endPositionName:"50"}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer&&(this.wlViewer.detach(),this.wlViewer=null),super.detach()}}function $n(e,t,n,s){const r=ge.g.forColumn(e);let i=null,o=null;for(let e=0;e<r.posList.length;++e)r.posList[e]==t&&(i=e),r.posList[e]==n&&(o=e);if(null===i&&null!==t)throw new Error(`Start position ${t} not found.`);if(null===o&&null!==n)throw new Error(`End position ${n} not found.`);if(r.posList.length<o)throw new Error(`End position ${o} exceeds positions length`);const a=s||`${e.name}: (${t??""}-${n??""})`;return r.getRegion(i,o,a)}const Ln={df:a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(fe.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Pn{constructor(e,t){this.urlParams=e,this.funcName=t}async init(e){this.data=e??Ln;const t=this.data.df.getCol(this.data.colName);this.data.positionNames&&t.setTag(fe.DX.positionNames,this.data.positionNames),this.data.regions&&t.setTag(fe.DX.regions,JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await i.data.detectSemanticTypes(this.data.df),this.view=i.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${us.name}.${this.funcName}`;const e=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(e,a.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Rn{constructor(e){this.call=e,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const t=e=>this.call.inputParams[e].property.description;this.inputs.table=o.tableInput("Table",this.call.inputParams.table.value??i.shell.tv.dataFrame,void 0,(()=>{}));const n=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(a.SEMTYPE.MACROMOLECULE),s={filter:e=>e.semType===a.SEMTYPE.MACROMOLECULE};this.inputs.sequence=o.columnInput("Sequence",i.shell.tv.dataFrame,n,this.sequenceInputChanged.bind(this),s),this.inputs.start=o.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=o.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=o.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=o.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const e in this.call.inputParams)o.tooltip.bind(this.inputs[e].captionLabel,t(e));this.sequenceInputChanged()}sequenceInputChanged(){const e=this.inputs.sequence.value;e&&ge.g.forColumn(e),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null;if(null!==t)this.inputs.start.value=t?.start,this.inputs.end.value=t?.end;else{const e=ge.g.forColumn(this.inputs.sequence.value);this.inputs.start.value=e.posList[0],this.inputs.end.value=e.posList[e.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const e=this.inputs.sequence.value,t=e?ge.g.forColumn(e):null,n=this.inputs.start.input,s=this.inputs.end.input;for(let e=n.options.length-1;e>=0;--e)n.options.remove(e);for(let e=s.options.length-1;e>=0;--e)s.options.remove(e);for(const e of t?.posList??[]){const t=document.createElement("option"),r=document.createElement("option");t.text=r.text=e,t.value=r.value=e,n.options.add(t),s.options.add(r)}n.value=t?.posList[0]??"",s.value=t?.posList[t?.posList.length-1]??""}updateRegionItems(){const e=this.inputs.sequence.value,t=e?e.getTag(fe.DX.regions):null,n=t?JSON.parse(t):null,s=this.inputs.region.input;for(let e=s.options.length-1;e>=0;--e)s.options.remove(e);const r=document.createElement("option");if(r.text="",r.value=JSON.stringify(null),s.options.add(r),null!=n){this.inputs.region.root.style.removeProperty("display");for(const e of n){const t=document.createElement("option");t.text=`${e.name}: ${e.start}-${e.end}`,t.value=JSON.stringify(e),s.options.add(t)}}else this.inputs.region.root.style.display="none"}updateRegion(e){const t=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";if(!this.fixRegion){const e=this.inputs.region.input;e.selectedIndex=-1;for(let s=e.options.length-1;s>=0;--s){const r=e.options[s],i=JSON.parse(r.value);i&&t===i.start&&n===i.end&&(e.selectedIndex=s)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const e=this.inputs.region.stringValue,t=e?JSON.parse(e):null,n=this.inputs.sequence.value,s=this.inputs.start.stringValue??"",r=this.inputs.end.stringValue??"";return null!=t?`${n.name}(${t.name}): ${t.start}-${t.end}`:`${n?.name}: (${s}-${r})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const e=this.inputs.name.stringValue;return""==e?null:e}dialog(){const e=o.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});o.dialog({title:"Get Region"}).add(e).onOK((()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{us.handleErrorUI(e)}))})).show()}widget(){const e=o.inputs(Object.entries(this.inputs).filter((([e,t])=>!["table","sequence"].includes(e))).map((([e,t])=>t))),t=o.button("Get Region",(()=>{(async()=>{const e=this.getParams();await this.call.func.prepare(e).call(!0)})().catch((e=>{us.handleErrorUI(e)}))}));return a.Widget.fromRoot(o.divV([e,o.div(t)]))}}var On=n(8601);const kn=OCL;class Dn{constructor(e){const t=e.split("|");t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}validateConnectionItem(e){const t="(PEPTIDE|RNA)",n=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(n))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const n=[],s=t.split(",");s[2].split("-").forEach(((e,t)=>{const r=s[t],i=e.split(":"),o={monomerIdx:parseInt(i[0])-1,rGroupId:parseInt(i[1].slice(1))};n.push({polymerId:r,bond:o})})),e.push(n)})),e}}class Fn{constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:n}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=n}get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),n=[],s=[];return t.forEach((e=>{n.push(e),s.push("Backbone")})),{monomers:n,monomerTypes:s}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if("Backbone"===e)return t})).filter((e=>void 0!==e)),n=this.monomerTypes.map(((e,t)=>{if("Branch"===e)return t})).filter((e=>void 0!==e));for(let n=0;n<t.length-1;n++){const s=t[n],r=t[n+1];e.push([{monomerIdx:s,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<n.length;t++){const s=n[t],r=s-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:s,rGroupId:1}])}return e}}class Gn{constructor(e){this.helmString=e;const t=this.helmString.split("$"),n=t[0].split("|");this.simplePolymers=n.map((e=>new Fn(e))),""!==t[1]&&(this.connectionList=new Dn(t[1])),this.bondData=this.getBondData(),this.bondedRGroupsMap=this.getBondedRGroupsMap()}getBondedRGroupsMap(){const e=new Map;return this.bondData.forEach((t=>{t.forEach((t=>{const n=t.monomerIdx,s=t.rGroupId;e.get(n)||e.set(n,[]),e.get(n).push(s)}))})),e}toString(){return this.helmString}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),n=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===n)throw new Error(`Cannot find simple polymer for monomer ${e}`);const s=Object.keys(t).find((e=>t[e]===n));return this.simplePolymers.find((e=>e.id===s))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((n=>{e[n.id]=t,t+=n.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((n=>{const s=n.getBondData(),r=e[n.id];this.shiftBondMonomerIds(r,s),t.push(...s)})),this.connectionList&&this.connectionList.getConnectionData().forEach((n=>{const s=[];n.forEach((t=>{const n=e[t.polymerId],r=t.bond;r.monomerIdx+=n,s.push(r)})),t.push(s)})),t}}class Bn{constructor(e){this.monomerSymbol=e}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:n}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-n})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],n=t.y/t.x,s=Math.atan(n);if(isNaN(s))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-s)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}class Vn{constructor(e,t,n){this.atoms=t,this.bonds=n,this.rGroupBondPositionMap=new Map,this.rGroupIdToAtomicIndexMap=e.getRGroupIdToAtomicIdxMap()}getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,n])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const n=this.bonds.getPositionsInBonds(t+1);if(0===n.length)throw new Error(`Cannot find position for R group ${e}`);if(n.length>1)throw new Error(`More than one position for R group ${e}`);const s=n[0];return this.bonds.replacePositionsInBondsByDummy([s]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),s}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,n]of this.rGroupIdToAtomicIndexMap)n>t&&this.rGroupIdToAtomicIndexMap.set(e,n-1)}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n}=t;this.bonds.deleteBondLines([n]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>n&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const n=this.rGroupBondPositionMap.get(e);if(!n)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s,nodeIdx:r}=n;this.bonds.bondedAtoms[s][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:s}=t;return this.bonds.bondedAtoms[n][(s+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,n)=>{const s=e[n-1];"H"===s?(this.removeRGroups([n]),this.deleteBondLineWithSpecifiedRGroup(n)):this.atoms.replaceRGroupSymbolByElement(t,s)}))}}class Un{constructor(){this.coordinates=[],this.rawAtomLines=[]}get atomCoordinates(){return this.coordinates}replaceRGroupSymbolByElement(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,n)=>!e.includes(n))),this.rawAtomLines=this.rawAtomLines.filter(((t,n)=>!e.includes(n)))}shift(e){this.coordinates=this.coordinates.map((t=>{const n=t.x+e.x,s=t.y+e.y;if(isNaN(n)||isNaN(s))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:n,y:s}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const n=t.x,s=t.y,r=n*Math.cos(e)-s*Math.sin(e),i=n*Math.sin(e)+s*Math.cos(e);if(isNaN(r)||isNaN(i))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:i}}))}}class Hn extends Un{constructor(e){super(),this.rawAtomLines=e.getAtomLines(),this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const n=this.coordinates[t];return`${n.x.toFixed(4).padStart(10," ")}${n.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}}class jn{constructor(){this.bondedAtomPairs=[],this.rawBondLines=[]}get bondedAtoms(){return this.bondedAtomPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,n)=>!e.includes(n))),this.bondedAtomPairs=this.bondedAtomPairs.filter(((t,n)=>!e.includes(n)))}getPositionsInBonds(e){const t=[];return this.bondedAtomPairs.forEach(((n,s)=>{n.forEach(((n,r)=>{n===e&&t.push({bondLineIdx:s,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:n,nodeIdx:s}=e;this.bondedAtomPairs[n][s]=t}))}removeAtomIdFromBonds(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedAtomPairs=this.bondedAtomPairs.map((t=>t.map((t=>t+e))))}}class Wn extends jn{constructor(e){super(),this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedAtomPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}}class Yn extends Bn{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Hn(n),this.bonds=new Wn(n),this.rGroups=new Vn(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class Zn extends Un{constructor(e){super(),this.molfileHandler=e,this.rawAtomLines=e.getAtomLines(),this.coordinates=this.getCoordinates()}getCoordinates(){const e=this.molfileHandler.x,t=this.molfileHandler.y;return Array.from(e).map(((e,n)=>({x:e,y:t[n]})))}get atomLines(){const e=/^(M V30 [^-]*)(-?\d+\.\d+)( )(-?\d+\.\d+)( -?\d+\.\d+.*)$/,t=/\sRGROUPS=\(\d+(\s+\d+)*\)/;return this.rawAtomLines.map(((n,s)=>{const r=this.coordinates[s],i=r.x.toFixed(4)+"00",o=r.y.toFixed(4)+"00";return n.replace(e,((e,t,n,s,r,a)=>t+i+s+o+a)).replace(t,"")}))}replaceRGroupSymbolByElement(e,t){super.replaceRGroupSymbolByElement(e,t);const n=this.rawAtomLines[e].substring(3).split(" ");n.length>7&&(this.rawAtomLines[e]=`M ${n.slice(0,7).join(" ")}`)}}class qn extends jn{constructor(e){super(),this.molfileHandler=e,this.rawBondLines=e.getBondLines(),this.bondedAtomPairs=this.getBondedAtomPairs()}getBondedAtomPairs(){return this.molfileHandler.pairsOfBondedAtoms.map((e=>[e[0],e[1]]))}getBondLines(){const e=/^(M\s+V30\s+\d+\s+\d+\s+)(\d+)(\s+)(\d+)(.*)$/;return this.bondedAtomPairs.map(((t,n)=>{if(t.some((e=>-1===e)))throw new Error(`Bonded pair ${t} contains -1`);return this.rawBondLines[n].replace(e,((e,n,s,r,i,o)=>`${n}${t[0]}${r}${t[1]}${o}`))}))}}class Kn extends Bn{constructor(e,t){super(t);const n=$t.getInstance(e);this.atoms=new Zn(n),this.bonds=new qn(n),this.rGroups=new Vn(n,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}}class zn{static getInstance(e,t){if($t.isMolfileV2K(e))return new Yn(e,t);if($t.isMolfileV3K(e))return new Kn(e,t);throw new Error("Unsupported molfile version")}}class Xn{constructor(e,t,n,s,r,i){this.monomerSymbol=e,this.monomerIdx=t,this.helm=n,this.monomerLib=i,this.capGroupElements=[];const o=this.getLibraryMonomerObject();let a=o.molfile;$t.isMolfileV2K(a)&&(a=this.convertMolfileToV3KFormat(a,e,r)),this.molfileWrapper=zn.getInstance(a,e),this.capGroupElements=this.getCapGroupElements(o),n.bondedRGroupsMap.has(t)&&this.removeRGroups(n.bondedRGroupsMap.get(t)),this.capRemainingRGroups(),this.shiftCoordinates(s)}convertMolfileToV3KFormat(e,t,n){let s=null;try{if(s=n.get_mol(e,JSON.stringify({mergeQueryHs:!0})),s)return s.get_v3Kmolblock();throw new Error(`Cannot convert ${t} to molV3000`)}finally{s?.delete()}}getLibraryMonomerObject(){const e=this.helm.getPolymerTypeByMonomerIdx(this.monomerIdx),t=this.monomerLib.getMonomer(e,this.monomerSymbol);if(!t)throw new Error(`Monomer ${this.monomerSymbol} is not found in the library`);return t}getCapGroupElements(e){return e.rgroups.map((e=>(e.capGroupSmiles||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeRGroups(e){this.molfileWrapper.removeRGroups(e)}capRemainingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Jn{constructor(e,t,n){this.rdKitModule=t,this.monomerLib=n,this.monomerWrappers=[],this.helm=new Gn(e)}addMonomer(e,t,n){const s=new Xn(e,t,this.helm,n,this.rdKitModule,this.monomerLib);this.monomerWrappers.push(s)}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((n=>{e.push(t),t+=n.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),n=e.map((e=>e.rGroupId)),s=t.map((e=>this.monomerWrappers[e])),r=s[1].getAttachmentAtomByRGroupId(n[1]);s[0].replaceRGroupWithAttachmentAtom(n[0],r),s[1].deleteBondLineWithSpecifiedRGroup(n[1])}))}compileToMolfile(){const e=[],t=[],n=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(n[t])})),this.restoreBondsBetweenMonomers(),this.monomerWrappers.forEach((n=>{e.push(...n.getAtomLines()),t.push(...n.getBondLines())}));const s=e.length,r=t.length;return[this.getV3KHeader(s,r),this.getV3KAtomBlock(e),this.getV3KBondBlock(t),"M V30 END CTAB\nM END"].join("\n")}getV3KHeader(e,t){return`\n Datagrok\n\n 0 0 0 0 0 0 0 0 0 0999 V3000\nM V30 BEGIN CTAB\nM V30 COUNTS ${e} ${t} 0 0 1`}getV3KAtomBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN ATOM",...e.map(((e,n)=>{const s=n+1;return e.replace(t,((e,t,n,r)=>t+s+r))})),"M V30 END ATOM"].join("\n")}getV3KBondBlock(e){const t=/^(M V30 )(\d+)( .*)$/;return["M V30 BEGIN BOND",...e.map(((e,n)=>{const s=n+1;return e.replace(t,((e,t,n,r)=>t+s+r))})),"M V30 END BOND"].join("\n")}}class Qn{constructor(e){this.molfileHandler=$t.getInstance(e)}get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class es{constructor(e,t){this.helmColumn=e,this.df=t,this.helmColumn=e}async convertToSmiles(){const e=await this.getSmilesList(),t=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(t,e.map((e=>null===e?"":e)))}async getSmilesList(){return(await this.convertToMolfileV3KColumn()).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}async getMolV3000ViaOCL(e,t){const n=e.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})),s=new Array(n.length),r=a.TaskBarProgressIndicator.create("Handling chirality...");for(let e=0;e<n.length;e++){const t=kn.Molecule.fromMolfile(n[e]).toMolfileV3();s[e]=t.replace("STERAC1","STEABS");const i=e/n.length*100;r.update(i,`${i?.toFixed(2)}% of molecules completed`)}return r.close(),a.Column.fromStrings(t,s)}async convertToRdKitBeautifiedMolfileColumn(e){const t=(await this.convertToMolfileV3KColumn()).toList(),n=await i.functions.call("Chem:getRdKitModule"),s=t.map((e=>{if(""===e)return null;const t=n.get_mol(e);return t?(t.set_new_coords(),t.normalize_depiction(1),t.straighten_depiction(!0),t):null})),r=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return e?await this.getMolV3000ViaOCL(s,r):a.Column.fromStrings(r,s.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}async convertToMolfileV3KColumn(){const e=await this.getPolymerGraphColumn(),t=await i.functions.call("Chem:getRdKitModule"),n=(await hs()).getBioLib(),s=e.toList().map(((e,s)=>{const r=this.helmColumn.get(s);if(!r)return"";let i="";try{i=this.getPolymerMolfile(r,e,t,n)}catch(e){const[t,n]=(0,Ce.yf)(e);us.logger.error(t,void 0,n)}finally{return i}})),r=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",r,s)}async getPolymerGraphColumn(){return await i.functions.call("HELM:getMolfiles",{col:this.helmColumn})}getPolymerMolfile(e,t,n,s){const r=new Qn(t),i=new Jn(e,n,s);return r.monomerSymbols.forEach(((e,t)=>{const n=r.getMonomerShifts(t);i.addMonomer(e,t,n)})),i.compileToMolfile()}}async function ts(e,t,n){const s=new es(t,e),r=await s.convertToRdKitBeautifiedMolfileColumn(n);return r.semType=a.SEMTYPE.MOLECULE,r}class ns{constructor(){this.maxIterations={uiName:"Max iterations",value:0,tooltip:"Maximum iterations for MCL process.Default is \n 0 which will construct the clusters with plain sparse matrix. Values greater than 0 will \n perform MCL with the given number of iterations and will result in trans-cluster activity cliff lines."},this.useWebGPU={uiName:"Use WebGPU",value:!1,tooltip:"Use WebGPU for MCL calculation. (Experimental)",type:"boolean"}}}class ss extends P{constructor(e={}){super({...e,enableMCL:!0});const t=this.tableInput.value.columns.numerical;this.activitiesInput=o.columnInput("Activities",this.tableInput.value,a.Utils.firstOrNull(t),null,{filter:e=>Array.from(t).includes(e)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=o.intInput("Similarity cutoff",80),this.methodsParams[$]=new ns}onTableInputChanged(){if(super.onTableInputChanged(),this.activitiesInputRoot){o.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=o.columnInput("Activities",this.tableInput.value,a.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((e=>this.activitiesInputRoot.append(e)))}}getEditor(){return o.div([this.tableInput,this.colInputRoot,this.preprocessingFunctionInputRoot,this.preprocessingFuncSettingsDiv,this.activitiesInputRoot,this.similarityMetricInputRoot,this.methodInput,this.methodSettingsDiv,this.similarityMetricInputRoot,this.similarityInput],{style:{minWidth:"320px"},classes:"ui-form dim-reduction-dialog-form"})}getParams(){return{...super.getParams(),activities:this.activitiesInput.value,similarityThreshold:this.similarityInput.value}}}function rs(e){const t=["Embed_X","Embed_Y"],n=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${n}`))}function is(e,t){return`${t} (${e.length>4?`${e.length} columns`:e.map((e=>e.name)).join(", ")})`}var os=n(706),as=n(6286);class ls{constructor(e){this.separator=e,this.separatorSplitter=(0,Ee.Ar)(this.separator),this.splitter=this._splitter.bind(this)}_splitter(e){const t=this.separatorSplitter(e);return new cs(t.originals,ge.lh[fe.r2.SEPARATOR])}}class cs extends Ee.wx{get canonicals(){if(!this._canonicals){const e=this.length;this._canonicals=new Array(e);for(let t=0;t<e;++t)this._canonicals[t]=this.getCanonical(t)}return this._canonicals}getCanonical(e){if(this.isGap(e))return as.G2;let t=this.seqCList[e];if(null===t){const n=this.getOriginal(e);t=n,")"===n[n.length-1]&&(t=this.seqCList[e]=n.replace(/\(\d+\)$/,""))}return t}constructor(e,t){super(e,t),this._canonicals=null,this.seqCList=new Array(this.length).fill(null)}}const us=new In;async function hs(){return await Ut.getInstance()}let ds=null;class ms{constructor(e){this._palette=e}get(e){return this._palette[e]}}let ps=null;async function fs(){const e="Bio: _package.initBio()";us.logger.debug(`${e}, start`);const t=await i.functions.call("Chem:getRdKitModule"),n=window.performance.now();await Promise.all([(async()=>{const e=await Ut.getInstance(),t=await(0,Tt.nW)();t.explicit&&(t.explicit=[],await(0,Tt.tW)(t)),await e.loadLibraries(),ps=e.getBioLib()})(),(async()=>{const e=await us.getProperties(),t=new _n(e);us.properties=t})()]).finally((()=>{us.completeInit();const t=window.performance.now();us.logger.debug(`${e}, loading ET: ${t-n} ms`)}));const s=[],r=[],o=ps.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(o).forEach((e=>{s.push(e);const n=o[e].replaceAll("#R","O "),i=t.get_mol(n),a=JSON.parse(i.get_descriptors()).CrippenClogP;r.push(a),i?.delete()}));const a=r.reduce(((e,t)=>e+t),0)/r.length||0,l={};for(let e=0;e<s.length;e++)l[s[e]]=r[e]<a?"#4682B4":"#DC143C";ds=new ms(l),us.logger.debug(`${e}, end`)}function gs(e){const t=new Nn(e);return t.init().then((()=>{})).catch((e=>{const t=e instanceof Error?e.message:e.toString();i.shell.error(t)})),t}function ys(){return ps}function bs(){return ps}function vs(e){return ge.g.forColumn(e)}function ws(e){const t="getRegionTopMenu",n=a.Func.find({package:us.name,name:t});if(1!==n.length)throw new Error(`Package '${us.name}' func '${t}' not found`);const s=n[0].prepare({table:e.dataFrame,sequence:e});return new Rn(s).widget()}async function Cs(e){return async function(){const e=o.label("Manage monomer libraries");return jt()(e).addClass("d4-link-action"),e.onclick=async()=>await Zt(),new a.Widget(e)}()}function As(e){try{new Rn(e).dialog()}catch(e){const t=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;i.shell.error(`Get region editor error: ${t}`),us.logger.error(t,void 0,n)}}function Ss(e){const t=new wn;o.dialog({title:"Split to Monomers"}).add(t.paramsUI).onOK((async()=>e.func.prepare(t.funcParams).call(!0))).show()}function xs(e){const t=new P({semtype:a.SEMTYPE.MACROMOLECULE});o.dialog({title:"Sequence Space"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({molecules:n.col,table:n.table,methodName:n.methodName,similarityMetric:n.similarityMetric,plotEmbeddings:n.plotEmbeddings,options:n.options,preprocessingFunction:n.preprocessingFunction,clusterEmbeddings:n.clusterEmbeddings}).call()})).show()}function Es(e){const t=new ss({semtype:a.SEMTYPE.MACROMOLECULE});o.dialog({title:"Activity Cliffs"}).add(t.getEditor()).onOK((async()=>{const n=t.getParams();return e.func.prepare({table:n.table,molecules:n.col,activities:n.activities,similarity:n.similarityThreshold,methodName:n.methodName,similarityMetric:n.similarityMetric,preprocessingFunction:n.preprocessingFunction,options:n.options}).call()})).show()}function Ts(){return new He}function _s(e){return function(e){const t=Array.from(e.dataFrame.columns).filter((e=>e.semType===a.SEMTYPE.MOLECULE)).map((e=>e.name));new Set(t).delete(e.name);let n=us.properties?us.properties.MaxMonomerLength:4;if(Me.maxMonomerLength in e.tags){const t=parseInt(e.getTag(Me.maxMonomerLength));n=isNaN(t)?n:t}if(".mm.cellRenderer.maxMonomerLength"in e.temp){const t=parseInt(e.temp[".mm.cellRenderer.maxMonomerLength"]);n=isNaN(t)?n:t}const s=o.input.int("Max Monomer Length",{value:n,nullable:!0,min:1,max:50,step:1,onValueChanged:()=>{if(0==s.value)setTimeout((()=>{s.value=null}),0);else{const t=s.value??"",n=null==t?"":t.toString();e.temp[".mm.cellRenderer.maxMonomerLength"]=n,e.temp[".mm.cellRenderer.settingsChanged"]=De.true,e.dataFrame.fireValuesChanged()}},tooltipText:"The max length of monomer symbol displayed without shortening, empty to no limit"}),r=o.input.int("Monomer Margin",{value:e.temp[".mm.cellRenderer.gapLength"]??0,onValueChanged:()=>{e.temp[".mm.cellRenderer.gapLength"]=r.value,e.temp[".mm.cellRenderer.settingsChanged"]=De.true,e.dataFrame.fireValuesChanged()},tooltipText:"The size of margin between monomers (in pixels)"}),i=o.input.bool("Color Code",{value:null==e?.temp["color-code"]||e.temp["color-code"],onValueChanged:()=>{e.temp["color-code"]=i.value,e.dataFrame.fireValuesChanged()},tooltipText:"Color code"}),l=o.input.string("Reference Sequence",{value:null!=e?.temp["reference-sequence"]?e?.temp["reference-sequence"]:"",nullable:!0,onValueChanged:()=>{e.temp["reference-sequence"]=l.value,e.dataFrame.fireValuesChanged()},tooltipText:"Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence"}),c=o.input.bool("Compare with current",{value:null==e?.temp["compare-with-current"]||e.temp["compare-with-current"],onValueChanged:()=>{e.temp["compare-with-current"]=c.value,e.dataFrame.fireValuesChanged()},tooltipText:'When on, all sequences get rendered in the "diff" mode'}),u=o.inputs([s,r,l,i,c]);return new a.Widget(u)}(e)}function Is(e){return(0,Mn.t)(e)}function Ms(){return new He}function Ns(){return new je}function $s(e,t,n,s,r){const i=new rt.k(s,r,n,t);return"Local alignment"==e?i.smithWaterman():i.needlemanWunch()}function Ls(){return new Je.OZ}function Ps(){return new st}function Rs(e,t,n,s){return $n(e,t??null,n??null,s??null)}async function Os(e,t,n,s,r){const o=$n(t,n??null,s??null,r??null);t.dataFrame.columns.add(o),await i.data.detectSemanticTypes(t.dataFrame)}async function ks(e,t,n,s,r,u,h,d){if(!(0,gn.n)(t,"Activity Cliffs"))return;const m=rs(e),p={units:t.getTag(a.TAGS.UNITS),aligned:t.getTag(fe.DX.aligned),separator:t.getTag(fe.DX.separator),alphabet:t.getTag(fe.DX.alphabet)},f=u,g=t,y=async()=>await me(e,g,m,"Activity cliffs",n,s,f,r,{...d??{}},a.SEMTYPE.MACROMOLECULE,p,h,ct,ut,pt),b=r===c.A.UMAP?2e5:2e4,v=r===c.A.UMAP?5e3:2e3;if(e.rowCount>b)return void i.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${b}`);const w=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,n)=>{e.rowCount>v&&!d?.[l.sS]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{y().then((e=>t(e))).catch((e=>n(e)))})).onCancel((()=>{t(void 0)})).show():y().then((e=>t(e))).catch((e=>n(e)))})).catch((e=>{const[t,n]=(0,Ce.yf)(e);throw us.logger.error(t,void 0,n),e})).finally((()=>{w.close()}))}async function Ds(e,t,n=1,s=.6,r="Morgan"){if(e.semType!==a.SEMTYPE.MACROMOLECULE)return{entries:e.toList(),options:{}};const{seqList:i,options:o}=await ot(e,t,r);return{entries:i,options:{...o,gapOpen:n,gapExtend:s}}}async function Fs(e,t){e.version!==e.temp["last-invalidated-version"]&&await(0,lt.HV)(e,!1);const n=e.temp["monomeric-mols"],s=await i.functions.call("Chem:getMorganFingerprints",{molColumn:n}),r=new Array(s.length).fill(null);for(let e=0;e<s.length;e++){if(s.isNone(e)||!s.get(e))continue;const t=s.get(e);r[e]=H.Z.fromUint32Array(t.length,new Uint32Array(t.getBuffer().buffer))}return{entries:r,options:{}}}async function Gs(e,t,s,r,c,u,h,d){if((0,gn.n)(t,"Sequence Space"))return u||(u=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??(h={}),await async function(e,t,s,r,c,u,h,d=!0,m=!1,p={preprocessingFuncArgs:[]},f={},g=null,y={}){const b={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==u.length||t.length!==c.length||t.length!==p.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const v=d?i.shell.tableView(e.name)??i.shell.addTableView(e):null,w=async()=>{const w=a.TaskBarProgressIndicator.create(`Initializing ${f.scatterPlotName??"dimensionality reduction"} ...`);let C;try{const A=rs(e);function S(n,r,i){let c=null,u=null;e.columns.names().includes(A[0])?(c=e.columns.byName(A[0]),u=e.columns.byName(A[1])):(c=e.columns.add(a.Column.float(A[0],e.rowCount)),u=e.columns.add(a.Column.float(A[1],e.rowCount)),d&&!C&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??is(t,s)}))),f[l.Ec]&&(C?.root&&o.setUpdateIndicator(C.root,!1),c.init((e=>i[0]?i[0][e]:void 0)),u.init((e=>i[1]?i[1][e]:void 0)));const h=n/r*100;w.update(h,`Running ${f.scatterPlotName??"dimensionality reduction"}... ${h.toFixed(0)}%`)}async function x(){e.columns.add(a.Column.float(A[0],e.rowCount)),e.columns.add(a.Column.float(A[1],e.rowCount));let n=null;d&&(C=v.scatterPlot({...b,x:A[0],y:A[1],title:f.scatterPlotName??is(t,s)}),o.setUpdateIndicator(C.root,!0));const m=i.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&C?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===C?.getOptions()?.look?.title&&(i.events.fireCustomEvent(W,{}),m.unsubscribe(),n?.(),w.close())})),g=new Promise((async(e,i)=>{try{n=e;const i=[];for(let e=0;e<u.length;++e){const n=u[e];if(p.distanceFnArgs||(p.distanceFnArgs=[]),n){const s=n.inputs[0].name,o=n.inputs[1].name,{entries:a,options:l}=await n.apply({[s]:t[e],[o]:r[e],...p.preprocessingFuncArgs[e]??{}});i.push({entries:a,options:l}),p.distanceFnArgs.push(l)}else{const n=t[e].toList(),s={};i.push({entries:n,options:s}),p.distanceFnArgs.push(s)}}e(await K(i.map((e=>e.entries)),s,r,c,h,p,f[l.sS]?void 0:S))}catch(e){i(e)}})),y=await g;return w.close(),m.unsubscribe(),y}const E=await x();if(m&&E){const T=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const _=await function(e,t,s,r){return un(this,void 0,void 0,(function*(){return new Promise((function(i,o){const a=new Worker(new URL(n.p+n.u(796),n.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:s}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):i(t)}}))}))}(E[0],E[1],p.dbScanEpsilon??.01,p.dbScanMinPts??4),I=e.columns.getUnusedName("Cluster (DBSCAN)");e.columns.addNewString(I).init((e=>_[e].toString())),C&&(C.props.colorColumnName=I)}catch(M){i.shell.error("Clustering embeddings failed"),console.error(M)}finally{T.close()}}if(E){const N=e.columns.byName(A[0]),$=e.columns.byName(A[1]);if(N.init((e=>E[0][e])),$.init((e=>E[1][e])),g)try{const L=g.inputs[0].name,P=g.inputs[1].name;await g.prepare({[L]:N,[P]:$,...y}).call(!0)}catch(R){i.shell.error("Post-processing failed"),console.error(R)}if(C)return o.setUpdateIndicator(C.root,!1),C.helpUrl="/help/compute/sequence-space",C}}catch(O){i.shell.error("Dimensionality reduction failed"),console.error(O),w.close(),C&&o.setUpdateIndicator(C.root,!1)}};return new Promise((async(t,n)=>{try{if(f.fastRowCount&&e.rowCount>f.fastRowCount&&!f[l.sS])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await w();t(e)}catch(e){n(e)}})).onCancel((()=>t(void 0))).show();else{const e=await w();t(e)}}catch(e){n(e)}}))}(e,[t],s,[r],[1],[u],"MANHATTAN",c,d??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[l.sS]})}async function Bs(e,t,n){const s=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{const s=(await hs()).getBioLib();await async function(e,t,n,s){if(0===a.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(n){const n=ge.g.forColumn(t);return n.isHelm()||(t=n.convert(fe.r2.HELM)),async function(e,t){const n=await ts(e,t);e.columns.add(n,!0),await i.data.detectSemanticTypes(e)}(e,t)}if(!(0,gn.n)(t,"To Atomic Level"))return;const r=await(0,On.i0)(e,t,s);null!==r.col&&(e.columns.add(r.col,!0),await i.data.detectSemanticTypes(e)),r.warnings&&r.warnings.length>0&&i.shell.warning(o.list(r.warnings))}(e,t,n,s)}finally{s.close()}}function Vs(){(0,bn.K)().catch((e=>{const[t,n]=(0,Ce.yf)(e);if(e instanceof yn.rE)return i.shell.warning(e.element),void us.logger.warning(t);i.shell.error(t),us.logger.error(t,void 0,n)}))}async function Us(e=null,t=null){return(0,bn.K)({col:e,clustersCol:t})}async function Hs(){const e=i.shell.tv,t=e.dataFrame.columns.toList().filter((e=>e.semType==a.SEMTYPE.MACROMOLECULE&&(ge.g.forColumn(e),!0))),n=async t=>{if(!(0,gn.n)(t,"Composition"))return;const n=e.addViewer("WebLogo",{sequenceColumnName:t.name});i.shell.tv.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let s=null;if(0!=t.length){if(t.length>1){const e=t.map((e=>e.name)),s=t.find((e=>ge.g.forColumn(e).isMsa())),r=o.choiceInput("Column",s?s.name:e[0],e);o.dialog({title:"Composition Analysis",helpUrl:"https://datagrok.ai/help/datagrok/solutions/domains/bio/#sequence-composition"}).add(o.div([r])).onOK((async()=>{const e=t.find((e=>e.name==r.value))??null;e&&await n(e)})).show()}else s=t[0];s&&await n(s)}else i.shell.error("Current table does not contain sequences")}function js(e){return new ye.i(e).importFasta()}function Ws(e){return console.log(e),[]}function Ys(){const e=(0,Ae.B)()[0];(0,St.O)(e)}function Zs(){return new Tn}async function qs(e){const t=a.TaskBarProgressIndicator.create("Test detectMacromolecule..."),n=(await i.dapi.files.list(e,!0,"")).filter((e=>e.fileName.endsWith(".csv")));let s=0;const r=[];for(const o of n)try{const t=await i.dapi.files.readAsText(e+o.fullPath),n=a.DataFrame.fromCsv(t);for(const e of n.columns)await i.functions.call("Bio:detectMacromolecule",{col:e})===a.SEMTYPE.MACROMOLECULE&&r.push({file:o.path,result:"detected",column:e.name,message:`units: ${e.getTag(a.TAGS.UNITS)}`})}catch(e){r.push({file:o.path,result:"error",column:null,message:e instanceof Error?e.message:e.toString()})}finally{s+=1,t.update(100*s/n.length,`Test ${o.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),t.close();const o=a.DataFrame.fromObjects(r);return o.name=`datasets_detectMacromolecule_${e}`,o}async function Ks(e,t){await(0,Cn.n)(e,t)}function zs(e){const t=ge.g.forColumn(e).stats;return Object.keys(t.freq)}function Xs(){return new vt}function Js(){const e=i.shell.v,t=e.addViewer("Sequence Similarity Search");e.dockManager.dock(t,"down")}function Qs(){return new Ct}function er(){const e=i.shell.v,t=e.addViewer("Sequence Diversity Search");e.dockManager.dock(t,"down")}function tr(e){const t=(0,Ae.B)();1===t.length?e.func.prepare({macromolecules:t[0]}).call(!0):new lt.uH(t)}function nr(e){i.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:e.name,columnName:e.name}),i.shell.tv.grid.scrollToCell(e,0)}async function sr(e,t,n){return we(e,t,n,pe.IDENTITY)}async function rr(e,t,n){return we(e,t,n,pe.SIMILARITY)}async function ir(){Zt()}function or(){(0,xt.C2)()}function ar(){return new Et.ST}async function lr(){const e=a.TaskBarProgressIndicator.create("WebLogo");try{const e=new URLSearchParams(window.location.search),t=new vn(e,"webLogoLargeApp"),n=await us.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function cr(){const e=a.TaskBarProgressIndicator.create("WebLogo ...");try{const e=new URLSearchParams(window.location.search),t=new vn(e,"webLogoAggApp"),n=await us.files.readCsv("samples/FASTA_PT_activity.csv");await i.data.detectSemanticTypes(n),await t.init(n)}finally{e.close()}}async function ur(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=new Pn(e,"getRegionApp");await t.init()}finally{e.close()}}async function hr(){const e=a.TaskBarProgressIndicator.create("getRegion ...");try{const e=new URLSearchParams(window.location.search),t=await us.files.readCsv("samples/HELM_empty_vals.csv"),n=new Pn(e,"getRegionHelmApp");await n.init({df:t,colName:"HELM"})}finally{e.close()}}function dr(){const e=a.DataFrame.fromColumns((0,os.io)());i.shell.addTableView(e)}function mr(){const e=a.DataFrame.fromColumns([(0,os.wl)(fe.r2.FASTA)]);i.shell.addTableView(e)}function pr(){const e=a.DataFrame.fromColumns([(0,os.wl)(fe.r2.HELM)]);i.shell.addTableView(e)}function fr(e,t){!function(e,t){const n=ge.g.forColumn(e.column),s=Object.values(fe.r2).filter((e=>e!==n.units));t.group("Copy").items(s,(t=>{const n=e.column,s=e.rowIndex,r=ge.g.forColumn(n),o=t===fe.r2.SEPARATOR?us.properties.DefaultSeparator:void 0,a=r.getJoiner({notation:t,separator:o})(r.getSplitted(s));navigator.clipboard?(navigator.clipboard.writeText(a),i.shell.info(`Value of notation '${t}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(e,t)}async function gr(){await async function(){let e,t;try{const n=new Qt("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await n.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,t=await us.files.readCsv(tn),e=i.shell.addTableView(t),e.grid.columns.byName("cluster").visible=!1,e.grid.columns.byName("sequence_id").visible=!1,e.grid.columns.byName("sequence").width=300,e.grid.columns.byName("activity").visible=!1,e.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const n=await t.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});e.dockManager.dock(n,a.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const n=await t.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});e.dockManager.dock(n,a.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{t.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{t.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(e){en(e)}}()}async function yr(){await async function(){let e,t,n,s,r;try{const o=new Qt("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await o.step("Load DNA sequences",(async()=>{[s,e,t]=await Promise.all([us.files.readCsv(hn),nn(),sn()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=200,n.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(e,t,n,s){let r;{const e=Object.values(Xt);for(let n=0;n<e.length;n++){const s=e[n];if(!t.col(s)){const r=n==e.length-1;t.columns.add(a.Column.float(s,t.rowCount),r)}}if(t.rowCount>=1){const s=t.getCol(n).toList(),r=Date.now();us.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const i=await K([s],"UMAP",[at.W.Levenshtein],[1],"MANHATTAN",{distanceFnArgs:[{}]}),o=Date.now();us.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-r)/1e3} s`);for(let n=0;n<e.length;n++){const s=e[n],r=t.getCol(s),o=i[n];r.init((e=>o[e]))}const a=Date.now();us.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}r=await t.plot.fromType(a.VIEWER.SCATTER_PLOT,{xColumnName:Xt.X,yColumnName:Xt.Y,lassoTool:!0})}return e.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),r}(n,s,dn),r.setOptions({color:"activity"})}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const r=await e.calcDistanceMatrix(s,[dn]),i=await on(r.data,s.rowCount,1),o=e.parseClusterMatrix(i);t.injectTreeForGrid(n.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{s.selection.set(65,!0)}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{[67,72,77,82,83,84,85,91,93].forEach((e=>s.selection.set(e,!0))),s.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(e){en(e)}}()}async function br(){await async function(){let e,t,n,s,r;const o=c.A.UMAP;try{const l=new Qt("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[n,e,t]=await Promise.all([us.files.readCsv(mn),nn(),sn()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=300,s.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{const e=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0];r=await ks(n,n.getCol("Sequence"),n.getCol("Activity"),80,o,it.U.LEVENSHTEIN,e,{}),s.dockManager.dock(r,a.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),jt()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const r=a.TaskBarProgressIndicator.create("Running sequence clustering..."),i=await e.calcDistanceMatrix(n,["sequence"]),o=await on(i.data,n.rowCount,1),l=e.parseClusterMatrix(o);r.close(),t.injectTreeForGrid(s.grid,l,void 0,150,void 0),s.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const e=r.dataFrame.temp[".cliffsDfGrid"];e.dataFrame.rowCount>0&&(e.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(e){en(e)}}()}async function vr(){await async function(){const e="HELM";let t,n,s;try{await new Qt("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,t=await us.files.readCsv("samples/HELM.csv"),n=i.shell.addTableView(t);for(let t=0;t<n.grid.columns.length;t++){const s=n.grid.columns.byIndex(t);[e,"Activity"].includes(s.name)||(s.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const n=t.getCol(e);await Bs(t,n,!1)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const n=`molfile(${e})`;t.currentCell=t.cell(1,n);const r=t.currentCell.value,i=new a.chem.Sketcher(a.chem.SKETCHER_MODE.INPLACE);i.setMolFile(r),s=o.dialog().add(i).show(),await(0,qe.gw)(3e3),s.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(e){en(e)}}()}async function wr(){await async function(){let e,t,n,s,r,o;const l="msa(HELM)",h=c.A.UMAP,d=(await pn.lp.getDockerContainer()).id,m=pn.lp.getDockerContainer();let p,f;try{const c=new Qt("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{[p,t]=await Promise.all([(async()=>(await m).status)(),us.files.readCsv(fn)]),e=i.shell.addTableView(t),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,"started"===p||"checking"===p?(us.logger.debug(`demoBio05UI(), PepSeA ('${pn.lp.dcName}') docker container status = '${p}'.`),f=Promise.resolve()):(us.logger.warning(`demoBio05UI(), PepSeA ('${pn.lp.dcName}') docker container is trying to start...`),await i.dapi.docker.dockerContainers.run(d),f=async function(e,t,n=3e4,s){const r=window.performance.now(),o=new u.Subject,a=async()=>{const n=await i.dapi.docker.dockerContainers.find(e);return n.status===t&&o.next(n),n};let l;try{await(0,qe.zg)(o,(e=>{const n=window.performance.now();s.debug(`awaitStatus(), docker container ('${e.name}') GET status = '${t}' in ${n-r} ms.`)}),(async()=>{const e=await a();s.debug(`awaitStatus(), docker container ('${e.name}') HAS status = '${e.status}'.`),l=window.setInterval(a,200)}),n)}finally{window.clearInterval(l)}}(d,"started",3e4,us.logger))}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{const e=a.TaskBarProgressIndicator.create("MSA by PepSeA ...");try{await f,n=t.getCol("HELM");const e=pn.Jy[0],r=1.53,o=0;if(s=await(0,pn.f3)(n,l,e,r,o,void 0),!s)throw new Error("Empty MSA result.");t.columns.add(s),await i.data.detectSemanticTypes(t)}finally{e.close()}}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{const n=a.Func.find({package:"Bio",name:"macromoleculePreprocessingFunction"})[0];o=await Gs(t,s,h,it.U.LEVENSHTEIN,!0,n),e.dockManager.dock(o,a.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await t.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),e.dockManager.dock(r,a.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(e){en(e)}}()}async function Cr(e){const t=(0,be.Xk)(e),n=JSON.stringify(t);a.Utils.download(`${e.name}.json`,n)}async function Ar(e,t,n){const s=await e.readAsString();await async function(e,t,n){const s=a.TaskBarProgressIndicator.create("detectMacromolecule probe ...");try{let r=0;const o=await i.functions.call("Bio:detectMacromoleculeEnableStore");let l=0;for(let c=0;c<n;++c){const u=a.DataFrame.fromCsv(e),h=t?u.getCol(t):u.columns.byIndex(0);await i.functions.call("Bio:detectMacromolecule",{col:h})!==a.SEMTYPE.MACROMOLECULE&&(++l,console.warn(`Reject reason: ${o.last.rejectReason}`));const d=c/n;d-r>=.1&&(r=d,s.update(100*d,`detectMacromolecule probe ${l}/${c}/${n} ...`),await(0,qe.gw)(0))}l>0?i.shell.warning(`detectMacromolecule failed ${l} / ${n}`):i.shell.info(`detectMacromolecule success ${n}`)}finally{s.close()}}(s,t,n)}async function Sr(e,t,n){return ts(e,t,n)}function xr(e,t){e.temp[ge.dm.notationProvider]=new ls(t)}},9017:(e,t,n)=>{"use strict";n.d(t,{k:()=>i});class s{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class r{constructor(e,t,n){this.seq1=e,this.seq2=t,this.score=n}}class i{fillNeedleman(){for(let e=0;e<=this.len1;e++)this.dpGrid[e][0].value=-e*this.gap,this.dpGrid[e][0].parentI=e-1,this.dpGrid[e][0].parentJ=0;for(let e=1;e<=this.len2;e++)this.dpGrid[0][e].value=-e*this.gap,this.dpGrid[0][e].parentI=0,this.dpGrid[0][e].parentJ=e-1}fillOne(e,t){this.dpGrid[e][t].value=Math.max(this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1],Math.max(this.dpGrid[e-1][t].value-this.gap,this.dpGrid[e][t-1].value-this.gap)),this.dpGrid[e][t].value==this.dpGrid[e-1][t-1].value+this.scores[e-1][t-1]?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t-1):this.dpGrid[e][t].value==this.dpGrid[e-1][t].value-this.gap?(this.dpGrid[e][t].parentI=e-1,this.dpGrid[e][t].parentJ=t):(this.dpGrid[e][t].parentI=e,this.dpGrid[e][t].parentJ=t-1)}gridFromName(e){switch(e){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(e,t){let n="",s="",i="";const o=this.dpGrid[e][t].value;for(let e=0;e<this.step;e++)i+="|";for(;e>0||t>0;){this.dpGrid[e][t].parentI==e?(n=i+n,s=this.seq2.substr((t-1)*this.step,this.step)+s):this.dpGrid[e][t].parentJ==t?(s=i+s,n=this.seq1.substr((e-1)*this.step,this.step)+n):(n=e-1>=0?this.seq1.substr((e-1)*this.step,this.step)+n:i+n,s=t-1>=0?this.seq2.substr((t-1)*this.step,this.step)+s:i+s);const r=e;e=this.dpGrid[e][t].parentI,t=this.dpGrid[r][t].parentJ}return new r(n,s,o)}fillScores(){this.scores=[];for(let e=0;e<this.len1;e++){this.scores.push([]);for(let t=0;t<this.len2;t++)this.scores[e].push(this.alignGrid[this.connections[this.seq1.substr(e*this.step,this.step)]][this.connections[this.seq2.substr(t*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new s);this.dpGrid.push(e)}this.fillNeedleman();for(let e=1;e<=this.len1;e++)for(let t=1;t<=this.len2;t++)this.fillOne(e,t);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let e=0;e<this.len1+1;e++){const e=[];for(let t=0;t<this.len2+1;t++)e.push(new s);this.dpGrid.push(e)}let e=0,t=0,n=0;for(let s=1;s<=this.len1;s++)for(let r=1;r<=this.len2;r++)this.fillOne(s,r),this.dpGrid[s][r].value<=0?(this.dpGrid[s][r].value=0,this.dpGrid[s][r].parentI=0,this.dpGrid[s][r].parentJ=0):0==this.dpGrid[this.dpGrid[s][r].parentI][this.dpGrid[s][r].parentJ].value&&(this.dpGrid[s][r].parentI=0,this.dpGrid[s][r].parentJ=0),this.dpGrid[s][r].value>e&&(e=this.dpGrid[s][r].value,t=s,n=r);return this.constructResult(t,n)}setSequences(e,t){this.seq1=e,this.seq2=t,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(e){this.gap=e}setMethod(e=""){"AUTO"==e&&(e=this.typeRec()),this.gridFromName(e)}constructor(e,t,n,s=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1,-2,-2,-3,-3,3,1,-2,1,-1,-2,-2,0,-3,-1,4,-3,-2,-1,-4],[-2,-1,3,4,-3,0,1,-1,0,-3,-4,0,-3,-3,-2,0,-1,-4,-3,-3,4,1,-1,-4],[-1,0,0,1,-3,3,4,-2,0,-3,-3,1,-1,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-2,0,0,-2,-1,-1,-1,-1,-1,-4],[-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,-4,1]],this.BLOSUM80=[[7,-3,-3,-3,-1,-2,-2,0,-3,-3,-3,-1,-2,-4,-1,2,0,-5,-4,-1,-3,-2,-1,-8],[-3,9,-1,-3,-6,1,-1,-4,0,-5,-4,3,-3,-5,-3,-2,-2,-5,-4,-4,-2,0,-2,-8],[-3,-1,9,2,-5,0,-1,-1,1,-6,-6,0,-4,-6,-4,1,0,-7,-4,-5,5,-1,-2,-8],[-3,-3,2,10,-7,-1,2,-3,-2,-7,-7,-2,-6,-6,-3,-1,-2,-8,-6,-6,6,1,-3,-8],[-1,-6,-5,-7,13,-5,-7,-6,-7,-2,-3,-6,-3,-4,-6,-2,-2,-5,-5,-2,-6,-7,-4,-8],[-2,1,0,-1,-5,9,3,-4,1,-5,-4,2,-1,-5,-3,-1,-1,-4,-3,-4,-1,5,-2,-8],[-2,-1,-1,2,-7,3,8,-4,0,-6,-6,1,-4,-6,-2,-1,-2,-6,-5,-4,1,6,-2,-8],[0,-4,-1,-3,-6,-4,-4,9,-4,-7,-7,-3,-5,-6,-5,-1,-3,-6,-6,-6,-2,-4,-3,-8],[-3,0,1,-2,-7,1,0,-4,12,-6,-5,-1,-4,-2,-4,-2,-3,-4,3,-5,-1,0,-2,-8],[-3,-5,-6,-7,-2,-5,-6,-7,-6,7,2,-5,2,-1,-5,-4,-2,-5,-3,4,-6,-6,-2,-8],[-3,-4,-6,-7,-3,-4,-6,-7,-5,2,6,-4,3,0,-5,-4,-3,-4,-2,1,-7,-5,-2,-8],[-1,3,0,-2,-6,2,1,-3,-1,-5,-4,8,-3,-5,-2,-1,-1,-6,-4,-4,-1,1,-2,-8],[-2,-3,-4,-6,-3,-1,-4,-5,-4,2,3,-3,9,0,-4,-3,-1,-3,-3,1,-5,-3,-2,-8],[-4,-5,-6,-6,-4,-5,-6,-6,-2,-1,0,-5,0,10,-6,-4,-4,0,4,-2,-6,-6,-3,-8],[-1,-3,-4,-3,-6,-3,-2,-5,-4,-5,-5,-2,-4,-6,12,-2,-3,-7,-6,-4,-4,-2,-3,-8],[2,-2,1,-1,-2,-1,-1,-1,-2,-4,-4,-1,-3,-4,-2,7,2,-6,-3,-3,0,-1,-1,-8],[0,-2,0,-2,-2,-1,-2,-3,-3,-2,-3,-1,-1,-4,-3,2,8,-5,-3,0,-1,-2,-1,-8],[-5,-5,-7,-8,-5,-4,-6,-6,-4,-5,-4,-6,-3,0,-7,-6,-5,16,3,-5,-8,-5,-5,-8],[-4,-4,-4,-6,-5,-3,-5,-6,3,-3,-2,-4,-3,4,-6,-3,-3,3,11,-3,-5,-4,-3,-8],[-1,-4,-5,-6,-2,-4,-4,-6,-5,4,1,-4,1,-2,-4,-3,0,-5,-3,7,-6,-4,-2,-8],[-3,-2,5,6,-6,-1,1,-2,-1,-6,-7,-1,-5,-6,-4,0,-1,-8,-5,-6,6,0,-3,-8],[-2,0,-1,1,-7,5,6,-4,0,-6,-5,1,-3,-6,-2,-1,-2,-5,-4,-4,0,6,-1,-8],[-1,-2,-2,-3,-4,-2,-2,-3,-2,-2,-2,-2,-2,-3,-3,-1,-1,-5,-3,-2,-3,-1,-2,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.BLOSUM90=[[5,-2,-2,-3,-1,-1,-1,0,-2,-2,-2,-1,-2,-3,-1,1,0,-4,-3,-1,-2,-1,-1,-6],[-2,6,-1,-3,-5,1,-1,-3,0,-4,-3,2,-2,-4,-3,-1,-2,-4,-3,-3,-2,0,-2,-6],[-2,-1,7,1,-4,0,-1,-1,0,-4,-4,0,-3,-4,-3,0,0,-5,-3,-4,4,-1,-2,-6],[-3,-3,1,7,-5,-1,1,-2,-2,-5,-5,-1,-4,-5,-3,-1,-2,-6,-4,-5,4,0,-2,-6],[-1,-5,-4,-5,9,-4,-6,-4,-5,-2,-2,-4,-2,-3,-4,-2,-2,-4,-4,-2,-4,-5,-3,-6],[-1,1,0,-1,-4,7,2,-3,1,-4,-3,1,0,-4,-2,-1,-1,-3,-3,-3,-1,4,-1,-6],[-1,-1,-1,1,-6,2,6,-3,-1,-4,-4,0,-3,-5,-2,-1,-1,-5,-4,-3,0,4,-2,-6],[0,-3,-1,-2,-4,-3,-3,6,-3,-5,-5,-2,-4,-5,-3,-1,-3,-4,-5,-5,-2,-3,-2,-6],[-2,0,0,-2,-5,1,-1,-3,8,-4,-4,-1,-3,-2,-3,-2,-2,-3,1,-4,-1,0,-2,-6],[-2,-4,-4,-5,-2,-4,-4,-5,-4,5,1,-4,1,-1,-4,-3,-1,-4,-2,3,-5,-4,-2,-6],[-2,-3,-4,-5,-2,-3,-4,-5,-4,1,5,-3,2,0,-4,-3,-2,-3,-2,0,-5,-4,-2,-6],[-1,2,0,-1,-4,1,0,-2,-1,-4,-3,6,-2,-4,-2,-1,-1,-5,-3,-3,-1,1,-1,-6],[-2,-2,-3,-4,-2,0,-3,-4,-3,1,2,-2,7,-1,-3,-2,-1,-2,-2,0,-4,-2,-1,-6],[-3,-4,-4,-5,-3,-4,-5,-5,-2,-1,0,-4,-1,7,-4,-3,-3,0,3,-2,-4,-4,-2,-6],[-1,-3,-3,-3,-4,-2,-2,-3,-3,-4,-4,-2,-3,-4,8,-2,-2,-5,-4,-3,-3,-2,-2,-6],[1,-1,0,-1,-2,-1,-1,-1,-2,-3,-3,-1,-2,-3,-2,5,1,-4,-3,-2,0,-1,-1,-6],[0,-2,0,-2,-2,-1,-1,-3,-2,-1,-2,-1,-1,-3,-2,1,6,-4,-2,-1,-1,-1,-1,-6],[-4,-4,-5,-6,-4,-3,-5,-4,-3,-4,-3,-5,-2,0,-5,-4,-4,11,2,-3,-6,-4,-3,-6],[-3,-3,-3,-4,-4,-3,-4,-5,1,-2,-2,-3,-2,3,-4,-3,-2,2,8,-3,-4,-3,-2,-6],[-1,-3,-4,-5,-2,-3,-3,-5,-4,3,0,-3,0,-2,-3,-2,-1,-3,-3,5,-4,-3,-2,-6],[-2,-2,4,4,-4,-1,0,-2,-1,-5,-5,-1,-4,-4,-3,0,-1,-6,-4,-4,4,0,-2,-6],[-1,0,-1,0,-5,4,4,-3,0,-4,-4,1,-2,-4,-2,-1,-1,-4,-3,-3,0,4,-1,-6],[-1,-2,-2,-2,-3,-1,-2,-2,-2,-2,-2,-1,-1,-2,-2,-1,-1,-3,-2,-2,-2,-1,-2,-6],[-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,-6,1]],this.NUCLEOTIDES=[[1,-1,-1,-1],[-1,1,-1,-1],[-1,-1,1,-1],[-1,-1,-1,1]],this.PAM30=[[6,-7,-4,-3,-6,-4,-2,-2,-7,-5,-6,-7,-5,-8,-2,0,-1,-13,-8,-2,-3,-3,-3,-17],[-7,8,-6,-10,-8,-2,-9,-9,-2,-5,-8,0,-4,-9,-4,-3,-6,-2,-10,-8,-7,-4,-6,-17],[-4,-6,8,2,-11,-3,-2,-3,0,-5,-7,-1,-9,-9,-6,0,-2,-8,-4,-8,6,-3,-3,-17],[-3,-10,2,8,-14,-2,2,-3,-4,-7,-12,-4,-11,-15,-8,-4,-5,-15,-11,-8,6,1,-5,-17],[-6,-8,-11,-14,10,-14,-14,-9,-7,-6,-15,-14,-13,-13,-8,-3,-8,-15,-4,-6,-12,-14,-9,-17],[-4,-2,-3,-2,-14,8,1,-7,1,-8,-5,-3,-4,-13,-3,-5,-5,-13,-12,-7,-3,6,-5,-17],[-2,-9,-2,2,-14,1,8,-4,-5,-5,-9,-4,-7,-14,-5,-4,-6,-17,-8,-6,1,6,-5,-17],[-2,-9,-3,-3,-9,-7,-4,6,-9,-11,-10,-7,-8,-9,-6,-2,-6,-15,-14,-5,-3,-5,-5,-17],[-7,-2,0,-4,-7,1,-5,-9,9,-9,-6,-6,-10,-6,-4,-6,-7,-7,-3,-6,-1,-1,-5,-17],[-5,-5,-5,-7,-6,-8,-5,-11,-9,8,-1,-6,-1,-2,-8,-7,-2,-14,-6,2,-6,-6,-5,-17],[-6,-8,-7,-12,-15,-5,-9,-10,-6,-1,7,-8,1,-3,-7,-8,-7,-6,-7,-2,-9,-7,-6,-17],[-7,0,-1,-4,-14,-3,-4,-7,-6,-6,-8,7,-2,-14,-6,-4,-3,-12,-9,-9,-2,-4,-5,-17],[-5,-4,-9,-11,-13,-4,-7,-8,-10,-1,1,-2,11,-4,-8,-5,-4,-13,-11,-1,-10,-5,-5,-17],[-8,-9,-9,-15,-13,-13,-14,-9,-6,-2,-3,-14,-4,9,-10,-6,-9,-4,2,-8,-10,-13,-8,-17],[-2,-4,-6,-8,-8,-3,-5,-6,-4,-8,-7,-6,-8,-10,8,-2,-4,-14,-13,-6,-7,-4,-5,-17],[0,-3,0,-4,-3,-5,-4,-2,-6,-7,-8,-4,-5,-6,-2,6,0,-5,-7,-6,-1,-5,-3,-17],[-1,-6,-2,-5,-8,-5,-6,-6,-7,-2,-7,-3,-4,-9,-4,0,7,-13,-6,-3,-3,-6,-4,-17],[-13,-2,-8,-15,-15,-13,-17,-15,-7,-14,-6,-12,-13,-4,-14,-5,-13,13,-5,-15,-10,-14,-11,-17],[-8,-10,-4,-11,-4,-12,-8,-14,-3,-6,-7,-9,-11,2,-13,-7,-6,-5,10,-7,-6,-9,-7,-17],[-2,-8,-8,-8,-6,-7,-6,-5,-6,2,-2,-9,-1,-8,-6,-6,-3,-15,-7,7,-8,-6,-5,-17],[-3,-7,6,6,-12,-3,1,-3,-1,-6,-9,-2,-10,-10,-7,-1,-3,-10,-6,-8,6,0,-5,-17],[-3,-4,-3,1,-14,6,6,-5,-1,-6,-7,-4,-5,-13,-4,-5,-6,-14,-9,-6,0,6,-5,-17],[-3,-6,-3,-5,-9,-5,-5,-5,-5,-5,-6,-5,-5,-8,-5,-3,-4,-11,-7,-5,-5,-5,-5,-17],[-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,-17,1]],this.PAM70=[[5,-4,-2,-1,-4,-2,-1,0,-4,-2,-4,-4,-3,-6,0,1,1,-9,-5,-1,-1,-1,-2,-11],[-4,8,-3,-6,-5,0,-5,-6,0,-3,-6,2,-2,-7,-2,-1,-4,0,-7,-5,-4,-2,-3,-11],[-2,-3,6,3,-7,-1,0,-1,1,-3,-5,0,-5,-6,-3,1,0,-6,-3,-5,5,-1,-2,-11],[-1,-6,3,6,-9,0,3,-1,-1,-5,-8,-2,-7,-10,-4,-1,-2,-10,-7,-5,5,2,-3,-11],[-4,-5,-7,-9,9,-9,-9,-6,-5,-4,-10,-9,-9,-8,-5,-1,-5,-11,-2,-4,-8,-9,-6,-11],[-2,0,-1,0,-9,7,2,-4,2,-5,-3,-1,-2,-9,-1,-3,-3,-8,-8,-4,-1,5,-2,-11],[-1,-5,0,3,-9,2,6,-2,-2,-4,-6,-2,-4,-9,-3,-2,-3,-11,-6,-4,2,5,-3,-11],[0,-6,-1,-1,-6,-4,-2,6,-6,-6,-7,-5,-6,-7,-3,0,-3,-10,-9,-3,-1,-3,-3,-11],[-4,0,1,-1,-5,2,-2,-6,8,-6,-4,-3,-6,-4,-2,-3,-4,-5,-1,-4,0,1,-3,-11],[-2,-3,-3,-5,-4,-5,-4,-6,-6,7,1,-4,1,0,-5,-4,-1,-9,-4,3,-4,-4,-3,-11],[-4,-6,-5,-8,-10,-3,-6,-7,-4,1,6,-5,2,-1,-5,-6,-4,-4,-4,0,-6,-4,-4,-11],[-4,2,0,-2,-9,-1,-2,-5,-3,-4,-5,6,0,-9,-4,-2,-1,-7,-7,-6,-1,-2,-3,-11],[-3,-2,-5,-7,-9,-2,-4,-6,-6,1,2,0,10,-2,-5,-3,-2,-8,-7,0,-6,-3,-3,-11],[-6,-7,-6,-10,-8,-9,-9,-7,-4,0,-1,-9,-2,8,-7,-4,-6,-2,4,-5,-7,-9,-5,-11],[0,-2,-3,-4,-5,-1,-3,-3,-2,-5,-5,-4,-5,-7,7,0,-2,-9,-9,-3,-4,-2,-3,-11],[1,-1,1,-1,-1,-3,-2,0,-3,-4,-6,-2,-3,-4,0,5,2,-3,-5,-3,0,-2,-1,-11],[1,-4,0,-2,-5,-3,-3,-3,-4,-1,-4,-1,-2,-6,-2,2,6,-8,-4,-1,-1,-3,-2,-11],[-9,0,-6,-10,-11,-8,-11,-10,-5,-9,-4,-7,-8,-2,-9,-3,-8,13,-3,-10,-7,-10,-7,-11],[-5,-7,-3,-7,-2,-8,-6,-9,-1,-4,-4,-7,-7,4,-9,-5,-4,-3,9,-5,-4,-7,-5,-11],[-1,-5,-5,-5,-4,-4,-4,-3,-4,3,0,-6,0,-5,-3,-3,-1,-10,-5,6,-5,-4,-2,-11],[-1,-4,5,5,-8,-1,2,-1,0,-4,-6,-1,-6,-7,-4,0,-1,-7,-4,-5,5,1,-2,-11],[-1,-2,-1,2,-9,5,5,-3,1,-4,-4,-2,-3,-9,-2,-2,-3,-10,-7,-4,1,5,-3,-11],[-2,-3,-2,-3,-6,-2,-3,-3,-3,-3,-4,-3,-3,-5,-3,-1,-2,-7,-5,-2,-2,-3,-3,-11],[-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,-11,1]],this.PAM250=[[2,-2,0,0,-2,0,0,1,-1,-1,-2,-1,-1,-3,1,1,1,-6,-3,0,0,0,0,-8],[-2,6,0,-1,-4,1,-1,-3,2,-2,-3,3,0,-4,0,0,-1,2,-4,-2,-1,0,-1,-8],[0,0,2,2,-4,1,1,0,2,-2,-3,1,-2,-3,0,1,0,-4,-2,-2,2,1,0,-8],[0,-1,2,4,-5,2,3,1,1,-2,-4,0,-3,-6,-1,0,0,-7,-4,-2,3,3,-1,-8],[-2,-4,-4,-5,12,-5,-5,-3,-3,-2,-6,-5,-5,-4,-3,0,-2,-8,0,-2,-4,-5,-3,-8],[0,1,1,2,-5,4,2,-1,3,-2,-2,1,-1,-5,0,-1,-1,-5,-4,-2,1,3,-1,-8],[0,-1,1,3,-5,2,4,0,1,-2,-3,0,-2,-5,-1,0,0,-7,-4,-2,3,3,-1,-8],[1,-3,0,1,-3,-1,0,5,-2,-3,-4,-2,-3,-5,0,1,0,-7,-5,-1,0,0,-1,-8],[-1,2,2,1,-3,3,1,-2,6,-2,-2,0,-2,-2,0,-1,-1,-3,0,-2,1,2,-1,-8],[-1,-2,-2,-2,-2,-2,-2,-3,-2,5,2,-2,2,1,-2,-1,0,-5,-1,4,-2,-2,-1,-8],[-2,-3,-3,-4,-6,-2,-3,-4,-2,2,6,-3,4,2,-3,-3,-2,-2,-1,2,-3,-3,-1,-8],[-1,3,1,0,-5,1,0,-2,0,-2,-3,5,0,-5,-1,0,0,-3,-4,-2,1,0,-1,-8],[-1,0,-2,-3,-5,-1,-2,-3,-2,2,4,0,6,0,-2,-2,-1,-4,-2,2,-2,-2,-1,-8],[-3,-4,-3,-6,-4,-5,-5,-5,-2,1,2,-5,0,9,-5,-3,-3,0,7,-1,-4,-5,-2,-8],[1,0,0,-1,-3,0,-1,0,0,-2,-3,-1,-2,-5,6,1,0,-6,-5,-1,-1,0,-1,-8],[1,0,1,0,0,-1,0,1,-1,-1,-3,0,-2,-3,1,2,1,-2,-3,-1,0,0,0,-8],[1,-1,0,0,-2,-1,0,0,-1,0,-2,0,-1,-3,0,1,3,-5,-3,0,0,-1,0,-8],[-6,2,-4,-7,-8,-5,-7,-7,-3,-5,-2,-3,-4,0,-6,-2,-5,17,0,-6,-5,-6,-4,-8],[-3,-4,-2,-4,0,-4,-4,-5,0,-1,-1,-4,-2,7,-5,-3,-3,0,10,-2,-3,-4,-2,-8],[0,-2,-2,-2,-2,-2,-2,-1,-2,4,2,-2,2,-1,-1,-1,0,-6,-2,4,-2,-2,-1,-8],[0,-1,2,3,-4,1,3,0,1,-2,-3,1,-2,-4,-1,0,0,-5,-3,-2,3,2,-1,-8],[0,0,1,3,-5,3,3,0,2,-2,-3,0,-2,-5,0,0,-1,-6,-4,-2,2,3,-1,-8],[0,-1,0,-1,-3,-1,-1,-1,-1,-1,-1,-1,-1,-2,-1,0,0,-4,-2,-1,-1,-1,-1,-8],[-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,-8,1]],this.SCHNEIDER=[[11.6,-2.7,9.7,-1.7,-2.7,-6.4,-3.9,-5.6,5.1,-5,3.6,-4.2,-6.3,-13,-7.1,-11.5,.4,-6,-1.9,-5.3,-8.5,-11.2,-8.9,-10.8,2.1,0,1.4,.2,-10.2,-13.5,-13,-12.5,-2.6,-8.5,-5,-8.1,-6.3,-9.9,-7.5,-9,-7.1,-10.2,-8.2,-9.2,-8.2,-12.5,-11.1,-11.4,-50,-14.8,-50,-13.8,-7.3,-10.1,-8.4,-9.1,-50,-13,-13.5,-12.4,-10.7,-18.1,-11.8,-17.2],[-2.7,13,-3.3,10.9,-3.5,-.4,-3.3,-1.8,-5.4,4.6,-5.5,3,-10.2,-7.9,-9.9,-9.6,-5,.5,-5.5,-1,-10.3,-8.1,-9.4,-9.6,-8.1,-5,-7.3,-6.3,-13.4,-11.3,-14.4,-12.9,-6.3,.8,-6.4,-1.1,-7.4,-5,-6.2,-6.5,-5.6,-1.6,-4.7,-3,-10.8,-8.7,-11.9,-10,-50,-6.2,-50,-7.5,-6.3,-4.3,-6.2,-5.4,-50,-7,-16.3,-8.2,-13.2,-12.3,-13.1,-13.3],[9.7,-3.3,11.6,-2.8,-4.5,-6.7,-3.1,-6.9,3.3,-5.5,4.8,-5.1,-8.9,-13.2,-5.7,-12.6,-1.5,-6.1,-.6,-6.1,-10,-11.8,-8.6,-11.9,1.2,.5,2.2,.1,-11.8,-14,-11.9,-13.4,-4.9,-9.1,-3.4,-8.9,-8,-10,-7.2,-10,-9.1,-10.2,-7.1,-9.9,-10.1,-13,-10.6,-12.7,-50,-14.9,-50,-14.4,-8.9,-10.8,-8.9,-10.4,-50,-13.1,-11.8,-13,-12.4,-19.4,-11.5,-17.8],[-1.7,10.9,-2.8,12.9,-2.7,-2.2,-2.8,.2,-4.8,2.9,-5.2,5.2,-9.1,-9.5,-9,-7,-4,-1,-5,1,-9,-8.8,-8.9,-7.7,-7,-6.8,-7.1,-4.3,-12.4,-12.9,-13.9,-10,-4.9,-.7,-5.6,1.4,-6,-6.5,-6.2,-4.8,-5.1,-3.2,-5,-1.2,-9.8,-9.9,-11.3,-8.2,-50,-7.6,-50,-5.1,-5.5,-5.8,-5.9,-4.2,-50,-8.3,-15.5,-5.9,-11.6,-14.2,-12,-11.6],[-2.7,-3.5,-4.5,-2.7,11.7,9,10.6,9.6,-3.2,-.7,-5.1,-.4,.7,-4.6,-.4,-3.6,-4.8,-8.9,-6.5,-7.8,-1.4,-4.1,-2.9,-3.3,-8,-9.1,-8,-8.2,-6,-9.3,-7.7,-8.5,-6.4,-10.1,-7.5,-8.6,2.8,-.7,.9,.1,-5.9,-7.3,-6.5,-6.5,-.4,-3.9,-2.6,-3.1,-50,-14.6,-50,-12.6,2.9,.1,1.8,1,-50,-9.2,-13.6,-7.7,-4.8,-12.2,-6.2,-11],[-6.4,-.4,-6.7,-2.2,9,12.3,9.8,9.6,-7.1,2.4,-7.2,.3,-2.9,-1.2,-3,-3.3,-7.6,-6.7,-8.1,-7.9,-4.9,-1.9,-4.5,-3.8,-9.5,-7.8,-9.3,-8.9,-9.4,-7.1,-9,-9,-9.4,-7.5,-9.3,-9.2,-.7,2.6,.2,-.1,-8,-4.6,-7.7,-6.1,-3.6,-1,-4.1,-3.1,-50,-11.6,-50,-11.6,.2,2.3,.4,.5,-50,-6.5,-15.3,-7.8,-8.4,-9.5,-8.3,-11.1],[-3.9,-3.3,-3.1,-2.8,10.6,9.8,12.2,9.8,-4.9,.1,-3.6,-.2,-1.7,-4.1,.9,-3.5,-5.9,-8.9,-5.6,-8.5,-3.9,-3.9,-2.2,-4.5,-7.3,-7.5,-6.4,-8.5,-7.1,-8.2,-6.7,-7.8,-7.9,-9.1,-7.1,-9.4,.9,-.2,2.5,-.3,-6.9,-6.5,-5.5,-6.8,-1.7,-3.4,-1.7,-2.8,-50,-13,-50,-11.5,1.5,.7,2.7,.6,-50,-8.9,-12.1,-7.4,-6.1,-11.5,-5.4,-10.4],[-5.6,-1.8,-6.9,.2,9.6,9.6,9.8,11.6,-6.6,.9,-7.2,2.5,-2.3,-3.4,-2.3,-.6,-6.5,-8.2,-8,-6.3,-3.7,-3.5,-3.9,-1.6,-9.9,-8.9,-9.6,-7,-8.6,-8.9,-8.8,-6.8,-8.6,-8.2,-8.8,-6.8,.3,.1,.2,2.4,-7.4,-6.2,-6.9,-4.4,-2.9,-2.9,-3.5,-.9,-50,-12.2,-50,-10.1,1.2,.6,1.2,2.4,-50,-7.6,-16.1,-5.8,-7.2,-10.8,-7.4,-9],[5.1,-5.4,3.3,-4.8,-3.2,-7.1,-4.9,-6.6,13.3,-2.8,11.2,-1.9,-5.7,-12.5,-7.2,-11.6,-.7,-4.8,-3.1,-4.3,-10,-11.6,-8.8,-11.7,10.5,7.7,9.1,8.5,-9.8,-12.7,-11.7,-11.8,-6.3,-11.4,-8.8,-11,-7.5,-10.3,-8.3,-9.9,-1.9,-6.7,-4.1,-6.4,-7.9,-12.5,-11.4,-11.7,-50,-14,-50,-13.2,-8.5,-10.4,-9.1,-9.6,-50,-9.8,-7.7,-8.8,-10.3,-17.9,-11.8,-16],[-5,4.6,-5.5,2.9,-.7,2.4,.1,.9,-2.8,12.8,-2.6,11,-8.4,-6.3,-8.3,-7.7,-6.1,-2.9,-6.5,-4.2,-8.5,-5.9,-7.5,-7.7,-5.5,-2.4,-5.5,-4.1,-12.9,-10.3,-12.7,-11.3,-7.4,-3.1,-7.4,-4.9,-4.4,-1.8,-3.5,-3.5,-1.6,3,-.8,.9,-8.4,-6.3,-9.6,-7.3,-50,-9,-50,-9.7,-2.3,-.2,-1.2,-1.5,-50,-.7,-13.3,-2,-11.8,-11.9,-12.3,-12.7],[3.6,-5.5,4.8,-5.2,-5.1,-7.2,-3.6,-7.2,11.2,-2.6,13.4,-2.1,-7.7,-12.5,-5.3,-11.9,-2.2,-4.4,-1.9,-4.8,-10.2,-11.5,-8.1,-12,9.3,8.2,10,8,-10.8,-11.9,-10.7,-12.4,-8.2,-11.8,-6.9,-11.5,-8.4,-9.9,-7.1,-10.6,-4.7,-6.8,-1.2,-7,-9.8,-11.6,-9.6,-12.1,-50,-14.1,-50,-12.7,-10,-10.8,-8.8,-10.5,-50,-9.2,-4.2,-9.3,-11,-18.2,-11.1,-16.1],[-4.2,3,-5.1,5.2,-.4,.3,-.2,2.5,-1.9,11,-2.1,13.2,-7.6,-8.5,-8,-5.3,-5.6,-4.5,-6.8,-2.4,-7.8,-7.9,-7.9,-6.2,-5.7,-5.1,-5.4,-2.1,-12.4,-12.3,-13.1,-10.1,-6.6,-4.4,-6.9,-2.6,-3.6,-3.8,-3.7,-2,-1.4,.8,-.9,3,-8.2,-8.1,-9.2,-5.8,-50,-10.1,-50,-7.4,-1.7,-2,-1.5,-.5,-50,-2.1,-12.6,-.4,-11.6,-13.9,-11.4,-11.1],[-6.3,-10.2,-8.9,-9.1,.7,-2.9,-1.7,-2.3,-5.7,-8.4,-7.7,-7.6,13.2,9.6,3.5,9.7,-8.7,-12.4,-10.7,-10.7,-7.8,-10.2,-8.8,-9.6,-9.5,-11.9,-10.9,-10.5,2.3,-.4,-.2,-.3,-9.7,-15.5,-11.4,-13.7,-3,-6.4,-4.1,-5.4,-9.6,-11.9,-10.5,-11.8,6.2,3.3,3.7,3.6,-50,-13.6,-50,-11.9,-5.6,-8.8,-7.2,-8.9,-50,-12.4,-14.1,-11.6,2.8,-6.4,.5,-5.2],[-13,-7.9,-13.2,-9.5,-4.6,-1.2,-4.1,-3.4,-12.5,-6.3,-12.5,-8.5,9.6,12.7,.2,10.5,-12.4,-11.6,-13.2,-12,-12.4,-10.1,-11.6,-12,-15.1,-13.1,-14.3,-13.4,-1.4,1.4,-1.6,-.5,-14.9,-14.3,-15.2,-16.8,-7.7,-4.7,-6.3,-6.6,-14.6,-10.8,-12.8,-13,2.3,6,2.5,3.6,-50,-11.2,-50,-11.9,-10.5,-9.2,-10.5,-10.5,-50,-10.3,-16.2,-11.3,-1.7,-3.7,-2.5,-5.4],[-7.1,-9.9,-5.7,-9,-.4,-3,.9,-2.3,-7.2,-8.3,-5.3,-8,3.5,.2,14.3,1,-7.3,-11.2,-6.9,-9.7,-8.5,-10.2,-7.7,-9.8,-10,-10.4,-8.4,-10.2,1,-.6,1.7,-.5,-11.1,-14.8,-9.7,-14.5,-3.7,-5.8,-3.1,-5.6,-10.4,-11.5,-8.2,-11.1,.6,-1.6,1.6,-1.1,-50,-12.4,-50,-11.5,-5.5,-8,-4.9,-7.2,-50,-12.4,-10.3,-11.6,.7,-6.8,2.4,-6],[-11.5,-9.6,-12.6,-7,-3.6,-3.3,-3.5,-.6,-11.6,-7.7,-11.9,-5.3,9.7,10.5,1,12.6,-12,-12.2,-12.5,-9.7,-11.1,-11.2,-11.9,-9.4,-12.9,-14.3,-14,-11.9,-1,-.4,-1.6,1.2,-13.9,-15.4,-13.7,-12.6,-6.2,-6.7,-6.3,-4.4,-13,-12.2,-13,-10.4,2.9,3.8,2.5,5.8,-50,-12.5,-50,-10.2,-9.6,-9.7,-9.6,-8.3,-50,-11.6,-15.4,-9.4,-1.1,-5.4,-1.6,-3.3],[.4,-5,-1.5,-4,-4.8,-7.6,-5.9,-6.5,-.7,-6.1,-2.2,-5.6,-8.7,-12.4,-7.3,-12,12.8,2.3,10.2,3,0,-3.4,-.7,-3.2,2.5,-.8,.9,.2,-3,-7.2,-5.7,-6.1,-.2,-6.6,-1.8,-6,-5.3,-8.2,-5.7,-7.6,-6.7,-9.6,-7.5,-9.3,-7.1,-10.5,-9.6,-9.4,-50,-8.1,-50,-7.2,-4.3,-6.8,-5.7,-6.3,-50,-9.5,-9.6,-8.9,-6.2,-12.8,-6.8,-11.8],[-6,.5,-6.1,-1,-8.9,-6.7,-8.9,-8.2,-4.8,-2.9,-4.4,-4.5,-12.4,-11.6,-11.2,-12.2,2.3,14.6,1.9,12.9,-5.5,-2.6,-4.1,-4.7,-1.2,3,-1.1,1.6,-8,-4.7,-8.7,-6,-8.2,-4.7,-7.8,-6.7,-10,-8.3,-8.9,-9.9,-10.8,-7.1,-10,-9.2,-11.6,-10.1,-12.3,-11.9,-50,2.2,-50,.9,-7.9,-5.9,-7.4,-6.9,-50,-4.6,-11.6,-5.6,-9.7,-5.9,-9.9,-7.3],[-1.9,-5.5,-.6,-5,-6.5,-8.1,-5.6,-8,-3.1,-6.5,-1.9,-6.8,-10.7,-13.2,-6.9,-12.5,10.2,1.9,11.9,2.1,-2.3,-4.1,-.5,-4.6,-.1,-.9,2.4,-.8,-5.1,-6.9,-4.8,-6.7,-2.3,-7.1,-.8,-7.2,-7.2,-8,-5.6,-8.5,-9.4,-9.7,-7.2,-9.8,-9.2,-11.1,-9.5,-10.7,-50,-8.7,-50,-8.6,-6.1,-7.5,-5.5,-7.7,-50,-10.4,-7.7,-10,-7.3,-13.6,-6.4,-13.3],[-5.3,-1,-6.1,1,-7.8,-7.9,-8.5,-6.3,-4.3,-4.2,-4.8,-2.4,-10.7,-12,-9.7,-9.7,3,12.9,2.1,14.7,-4.9,-3.8,-4,-2.4,-1,.8,-1.3,3.4,-7.6,-5.7,-8.1,-3.5,-6.8,-5.8,-7.2,-4.2,-8.9,-10.2,-8.4,-8.2,-9.9,-8.4,-9.7,-6.4,-11.1,-11.1,-11.8,-10,-50,.4,-50,2.6,-7.2,-7,-7.4,-5.1,-50,-5.7,-9.8,-3.2,-8.4,-7.4,-8.9,-5.9],[-8.5,-10.3,-10,-9,-1.4,-4.9,-3.9,-3.7,-10,-8.5,-10.2,-7.8,-7.8,-12.4,-8.5,-11.1,0,-5.5,-2.3,-4.9,12.6,10,11.1,10.5,-6,-8.3,-6.9,-7.5,-2.2,-7.4,-5.3,-5.9,-8.9,-12.5,-9.4,-11.6,-.7,-3.9,-2.3,-3,-9.1,-9.8,-9.2,-9.5,-5.6,-9,-8,-8.5,-50,-15.3,-50,-14.1,2.3,-1.4,.3,-.5,-50,-13.6,-14.3,-11.5,-5.3,-13.7,-6.1,-12.7],[-11.2,-8.1,-11.8,-8.8,-4.1,-1.9,-3.9,-3.5,-11.6,-5.9,-11.5,-7.9,-10.2,-10.1,-10.2,-11.2,-3.4,-2.6,-4.1,-3.8,10,13.1,10.7,10.6,-8.1,-5.2,-8,-6.7,-6.1,-3.7,-7.5,-5.6,-11.1,-10.3,-10.6,-11.9,-3.2,-1,-2.2,-2.8,-10.5,-8.1,-9.4,-9.5,-8.3,-6.9,-9.4,-8.8,-50,-11.3,-50,-12.8,-.6,2.2,-.3,.1,-50,-10.1,-17.5,-11.1,-8.6,-9.9,-8.6,-11.9],[-8.9,-9.4,-8.6,-8.9,-2.9,-4.5,-2.2,-3.9,-8.8,-7.5,-8.1,-7.9,-8.8,-11.6,-7.7,-11.9,-.7,-4.1,-.5,-4,11.1,10.7,13.2,10.4,-5.7,-5.8,-3.5,-6.1,-3.6,-6.5,-3.3,-5.5,-9.4,-11,-8.7,-11.2,-1.8,-2.7,.7,-3,-9.1,-8.2,-7.3,-9.4,-7.2,-8.2,-7.2,-8.2,-50,-13.2,-50,-13.3,.5,-.9,1.8,-.6,-50,-11.4,-11.1,-10.5,-6.1,-12.9,-5,-11.9],[-10.8,-9.6,-11.9,-7.7,-3.3,-3.8,-4.5,-1.6,-11.7,-7.7,-12,-6.2,-9.6,-12,-9.8,-9.4,-3.2,-4.7,-4.6,-2.4,10.5,10.6,10.4,12.6,-8.2,-7.9,-9,-4.7,-6.1,-6,-7.5,-2.9,-10.9,-12.2,-11.2,-10.9,-2.4,-2.9,-2.7,-.9,-10.4,-9.7,-10.2,-8,-8.4,-9.1,-9.3,-6.5,-50,-13.3,-50,-11,-0,-.4,-.4,2.3,-50,-10.9,-17.2,-8.3,-8.3,-12.7,-7.8,-9.3],[2.1,-8.1,1.2,-7,-8,-9.5,-7.3,-9.9,10.5,-5.5,9.3,-5.7,-9.5,-15.1,-10,-12.9,2.5,-1.2,-.1,-1,-6,-8.1,-5.7,-8.2,13.8,11.3,11.8,12.1,-6,-9.1,-9,-9.5,-8.9,-13.4,-10,-13.1,-9.9,-11.7,-9.8,-12.8,-5.9,-9.4,-6.5,-8.1,-10.7,-14,-13.3,-13.9,-50,-11.9,-50,-9.7,-8.9,-10.8,-9,-11.1,-50,-6.5,-5.3,-6.3,-10.5,-16.2,-10.4,-15.2],[0,-5,.5,-6.8,-9.1,-7.8,-7.5,-8.9,7.7,-2.4,8.2,-5.1,-11.9,-13.1,-10.4,-14.3,-.8,3,-.9,.8,-8.3,-5.2,-5.8,-7.9,11.3,15,11.2,12.8,-9.7,-5.3,-9.2,-7.8,-11.7,-10.6,-10.1,-12.2,-11.7,-8.8,-8.9,-11.8,-9.3,-5,-8,-8.2,-13.6,-11.4,-12.8,-13,-50,-7.2,-50,-8.4,-11,-7.7,-8.7,-10.2,-50,-1.5,-7.1,-4.9,-11.2,-11.6,-11.6,-15],[1.4,-7.3,2.2,-7.1,-8,-9.3,-6.4,-9.6,9.1,-5.5,10,-5.4,-10.9,-14.3,-8.4,-14,.9,-1.1,2.4,-1.3,-6.9,-8,-3.5,-9,11.8,11.2,13.4,11.4,-7.3,-8.8,-6.5,-8.5,-10,-12.5,-7.8,-12.5,-9.6,-11,-7.1,-10.7,-7.9,-8,-4.3,-9.4,-11.4,-12.3,-10.9,-12.9,-50,-11.8,-50,-11.2,-9.4,-9.8,-7.3,-10.5,-50,-6.2,-2.2,-6.7,-9.8,-15.2,-8.5,-14.9],[.2,-6.3,.1,-4.3,-8.2,-8.9,-8.5,-7,8.5,-4.1,8,-2.1,-10.5,-13.4,-10.2,-11.9,.2,1.6,-.8,3.4,-7.5,-6.7,-6.1,-4.7,12.1,12.8,11.4,14.7,-8.7,-7.4,-9.4,-5.3,-9.9,-11.8,-10.5,-10.3,-9.9,-10.1,-9.3,-9.3,-8.1,-7.2,-8,-5.2,-12,-12.1,-12.6,-10.9,-50,-7.9,-50,-5.3,-9.3,-8.8,-8.9,-7,-50,-3.6,-7.1,-1.2,-10.2,-12.7,-9.9,-11],[-10.2,-13.4,-11.8,-12.4,-6,-9.4,-7.1,-8.6,-9.8,-12.9,-10.8,-12.4,2.3,-1.4,1,-1,-3,-8,-5.1,-7.6,-2.2,-6.1,-3.6,-6.1,-6,-9.7,-7.3,-8.7,11.2,7.9,8.9,8.1,-12.1,-17.4,-13.2,-16.8,-6.3,-9.5,-7.5,-8.8,-12.7,-15.2,-13.1,-14.2,0,-3.1,-1.8,-3.1,-50,-10.7,-50,-9.3,-4.6,-8.9,-5.9,-8.3,-50,-12.8,-9.6,-10.6,9.5,-3.2,8.2,-2.8],[-13.5,-11.3,-14,-12.9,-9.3,-7.1,-8.2,-8.9,-12.7,-10.3,-11.9,-12.3,-.4,1.4,-.6,-.4,-7.2,-4.7,-6.9,-5.7,-7.4,-3.7,-6.5,-6,-9.1,-5.3,-8.8,-7.4,7.9,11.9,7.8,9.3,-15.2,-15.1,-14.6,-17.2,-9.7,-7.3,-8.2,-9.2,-15,-12.8,-14.1,-14.9,-2.8,.2,-2.9,-2.3,-50,-7.4,-50,-8.7,-9.4,-7.3,-9.4,-9.4,-50,-8,-11.9,-9.7,6.5,.5,6.4,-1.8],[-13,-14.4,-11.9,-13.9,-7.7,-9,-6.7,-8.8,-11.7,-12.7,-10.7,-13.1,-.2,-1.6,1.7,-1.6,-5.7,-8.7,-4.8,-8.1,-5.3,-7.5,-3.3,-7.5,-9,-9.2,-6.5,-9.4,8.9,7.8,10.1,7.8,-14.3,-17.7,-13,-17.8,-8,-9.4,-6.2,-9.2,-15.1,-14.9,-12.2,-14.9,-1.8,-3.2,-.8,-3.2,-50,-10.8,-50,-9.9,-7.3,-9.6,-6.4,-9.4,-50,-12.3,-8.7,-11.3,7.6,-3.3,8.7,-2.9],[-12.5,-12.9,-13.4,-10,-8.5,-9,-7.8,-6.8,-11.8,-11.3,-12.4,-10.1,-.3,-.5,-.5,1.2,-6.1,-6,-6.7,-3.5,-5.9,-5.6,-5.5,-2.9,-9.5,-7.8,-8.5,-5.3,8.1,9.3,7.8,11.8,-14.4,-15.7,-14.5,-14.6,-8.4,-8.7,-7.9,-7.1,-14.3,-13.8,-13.8,-12.3,-2.4,-2.2,-2.9,-.2,-50,-8.9,-50,-7.1,-8.1,-9.1,-8.7,-6.6,-50,-9.7,-11.4,-8,6.8,-1.8,6.9,.4],[-2.6,-6.3,-4.9,-4.9,-6.4,-9.4,-7.9,-8.6,-6.3,-7.4,-8.2,-6.6,-9.7,-14.9,-11.1,-13.9,-.2,-8.2,-2.3,-6.8,-8.9,-11.1,-9.4,-10.9,-8.9,-11.7,-10,-9.9,-12.1,-15.2,-14.3,-14.4,11.1,2.9,9.2,3.5,-3,-7,-4.3,-6.2,-2.2,-6.6,-3.7,-5.7,-6,-10.4,-8.6,-9.5,-50,-15.5,-50,-13.9,-7.8,-10.5,-8.7,-9.6,-50,-16.5,-17.1,-14.8,-12.1,-18.9,-12.4,-17.4],[-8.5,.8,-9.1,-.7,-10.1,-7.5,-9.1,-8.2,-11.4,-3.1,-11.8,-4.4,-15.5,-14.3,-14.8,-15.4,-6.6,-4.7,-7.1,-5.8,-12.5,-10.3,-11,-12.2,-13.4,-10.6,-12.5,-11.8,-17.4,-15.1,-17.7,-15.7,2.9,12.5,3.1,10.3,-7.7,-5.2,-6.2,-7.3,-5.4,-1.7,-5.4,-3.7,-11.6,-9.1,-13,-10.8,-50,-10.3,-50,-11.2,-9.8,-8.3,-9.1,-9.7,-50,-12.7,-20.6,-13.1,-16,-16.6,-17,-18.4],[-5,-6.4,-3.4,-5.6,-7.5,-9.3,-7.1,-8.8,-8.8,-7.4,-6.9,-6.9,-11.4,-15.2,-9.7,-13.7,-1.8,-7.8,-.8,-7.2,-9.4,-10.6,-8.7,-11.2,-10,-10.1,-7.8,-10.5,-13.2,-14.6,-13,-14.5,9.2,3.1,10.8,3,-4.5,-6.7,-2.7,-6.7,-5,-6.8,-2.5,-6.7,-7.5,-10.4,-7.4,-10.2,-50,-15.5,-50,-14.2,-8.9,-10.2,-8.5,-10,-50,-15.6,-15.3,-15.5,-13,-18.8,-12.6,-18.3],[-8.1,-1.1,-8.9,1.4,-8.6,-9.2,-9.4,-6.8,-11,-4.9,-11.5,-2.6,-13.7,-16.8,-14.5,-12.6,-6,-6.7,-7.2,-4.2,-11.6,-11.9,-11.2,-10.9,-13.1,-12.2,-12.5,-10.3,-16.8,-17.2,-17.8,-14.6,3.5,10.3,3,12.4,-6.9,-7.5,-6.8,-4.9,-5.4,-4.2,-5.4,-1.3,-10.8,-11.5,-12.4,-8.2,-50,-12.5,-50,-8.9,-9.2,-10,-9.4,-7.9,-50,-14.3,-19.9,-11.4,-16.2,-19.2,-15.8,-15.9],[-6.3,-7.4,-8,-6,2.8,-.7,.9,.3,-7.5,-4.4,-8.4,-3.6,-3,-7.7,-3.7,-6.2,-5.3,-10,-7.2,-8.9,-.7,-3.2,-1.8,-2.4,-9.9,-11.7,-9.6,-9.9,-6.3,-9.7,-8,-8.4,-3,-7.7,-4.5,-6.9,11.3,8.2,9.4,9.1,-1,-3.3,-1.8,-2.4,1.5,-2.1,-.4,-1.1,-50,-14.5,-50,-12.9,2.8,-0,1.4,.7,-50,-8.7,-14.1,-7.5,-5.2,-12.5,-6.5,-10.7],[-9.9,-5,-10,-6.5,-.7,2.6,-.2,.1,-10.3,-1.8,-9.9,-3.8,-6.4,-4.7,-5.8,-6.7,-8.2,-8.3,-8,-10.2,-3.9,-1,-2.7,-2.9,-11.7,-8.8,-11,-10.1,-9.5,-7.3,-9.4,-8.7,-7,-5.2,-6.7,-7.5,8.2,11.6,8.8,9.1,-3.7,-.9,-3.1,-3,-2,1.2,-2.3,-1.3,-50,-12.1,-50,-12.6,.1,2.5,.7,.6,-50,-6,-14.8,-7.5,-8.6,-9.4,-8.5,-11.2],[-7.5,-6.2,-7.2,-6.2,.9,.2,2.5,.2,-8.3,-3.5,-7.1,-3.7,-4.1,-6.3,-3.1,-6.3,-5.7,-8.9,-5.6,-8.4,-2.3,-2.2,.7,-2.7,-9.8,-8.9,-7.1,-9.3,-7.5,-8.2,-6.2,-7.9,-4.3,-6.2,-2.7,-6.8,9.4,8.8,12.1,8.8,-2.1,-2,.1,-2.4,0,-1.1,1.3,-.8,-50,-11.9,-50,-12.6,1.2,.7,3.5,.8,-50,-7.1,-12.4,-7.1,-7.1,-10.6,-5,-10.6],[-9,-6.5,-10,-4.8,.1,-.1,-.3,2.4,-9.9,-3.5,-10.6,-2,-5.4,-6.6,-5.6,-4.4,-7.6,-9.9,-8.5,-8.2,-3,-2.8,-3,-.9,-12.8,-11.8,-10.7,-9.3,-8.8,-9.2,-9.2,-7.1,-6.2,-7.3,-6.7,-4.9,9.1,9.1,8.8,11.2,-3.1,-3,-3.3,-1,-1.1,-1.4,-2,1.2,-50,-12.8,-50,-10.9,.8,.5,.7,2.3,-50,-7.5,-16.5,-5.9,-7.8,-11.1,-7.8,-9],[-7.1,-5.6,-9.1,-5.1,-5.9,-8,-6.9,-7.4,-1.9,-1.6,-4.7,-1.4,-9.6,-14.6,-10.4,-13,-6.7,-10.8,-9.4,-9.9,-9.1,-10.5,-9.1,-10.4,-5.9,-9.3,-7.9,-8.1,-12.7,-15,-15.1,-14.3,-2.2,-5.4,-5,-5.4,-1,-3.7,-2.1,-3.1,12.8,9.6,11.1,10.1,-4.8,-9.4,-8.1,-8.6,-50,-18.3,-50,-15.4,-5.9,-7.5,-6.6,-7.1,-50,-9.5,-11.7,-8.4,-12.5,-17.3,-13.2,-15.4],[-10.2,-1.6,-10.2,-3.2,-7.3,-4.6,-6.5,-6.2,-6.7,3,-6.8,.8,-11.9,-10.8,-11.5,-12.2,-9.6,-7.1,-9.7,-8.4,-9.8,-8.1,-8.2,-9.7,-9.4,-5,-8,-7.2,-15.2,-12.8,-14.9,-13.8,-6.6,-1.7,-6.8,-4.2,-3.3,-.9,-2,-3,9.6,12.8,9.7,10.5,-8.5,-5.6,-9.3,-7.8,-50,-12.7,-50,-13.8,-6.8,-5.1,-5.3,-6.5,-50,-4.1,-12.8,-5.8,-14.4,-14.1,-13.6,-14.8],[-8.2,-4.7,-7.1,-5,-6.5,-7.7,-5.5,-6.9,-4.1,-.8,-1.2,-.9,-10.5,-12.8,-8.2,-13,-7.5,-10,-7.2,-9.7,-9.2,-9.4,-7.3,-10.2,-6.5,-8,-4.3,-8,-13.1,-14.1,-12.2,-13.8,-3.7,-5.4,-2.5,-5.4,-1.8,-3.1,.1,-3.3,11.1,9.7,12.9,9.8,-5.5,-8.1,-5.4,-7.8,-50,-16.4,-50,-14.8,-5.9,-7.1,-4.7,-7.2,-50,-8.4,-6.4,-8.1,-12.1,-16.2,-10.3,-15.8],[-9.2,-3,-9.9,-1.2,-6.5,-6.1,-6.8,-4.4,-6.4,.9,-7,3,-11.8,-13,-11.1,-10.4,-9.3,-9.2,-9.8,-6.4,-9.5,-9.5,-9.4,-8,-8.1,-8.2,-9.4,-5.2,-14.2,-14.9,-14.9,-12.3,-5.7,-3.7,-6.7,-1.3,-2.4,-3,-2.4,-1,10.1,10.5,9.8,13.1,-7.2,-8,-8.4,-5,-50,-14.7,-50,-11.4,-6.3,-6.7,-5.8,-5,-50,-6.1,-13.4,-3.6,-13,-16,-13.7,-13.3],[-8.2,-10.8,-10.1,-9.8,-.4,-3.6,-1.7,-2.9,-7.9,-8.4,-9.8,-8.2,6.2,2.3,.6,2.9,-7.1,-11.6,-9.2,-11.1,-5.6,-8.3,-7.2,-8.4,-10.7,-13.6,-11.4,-12,0,-2.8,-1.8,-2.4,-6,-11.6,-7.5,-10.8,1.5,-2,0,-1.1,-4.8,-8.5,-5.5,-7.2,11.9,8.6,10,9,-50,-14.2,-50,-12.8,-4.1,-7.4,-5.7,-6.5,-50,-11,-14.3,-9.9,1.4,-7.9,-.7,-6.8],[-12.5,-8.7,-13,-9.9,-3.9,-1,-3.4,-2.9,-12.5,-6.3,-11.6,-8.1,3.3,6,-1.6,3.8,-10.5,-10.1,-11.1,-11.1,-9,-6.9,-8.2,-9.1,-14,-11.4,-12.3,-12.1,-3.1,.2,-3.2,-2.2,-10.4,-9.1,-10.4,-11.5,-2.1,1.2,-1.1,-1.4,-9.4,-5.6,-8.1,-8,8.6,12.4,8.6,9.5,-50,-10.4,-50,-11.6,-7.2,-5.7,-7.5,-7.4,-50,-8.6,-15.7,-9.7,-3,-3.7,-3.2,-5.9],[-11.1,-11.9,-10.6,-11.3,-2.6,-4.1,-1.7,-3.5,-11.4,-9.6,-9.6,-9.2,3.7,2.5,1.6,2.5,-9.6,-12.3,-9.5,-11.8,-8,-9.4,-7.2,-9.3,-13.3,-12.8,-10.9,-12.6,-1.8,-2.9,-.8,-2.9,-8.6,-13,-7.4,-12.4,-.4,-2.3,1.3,-2,-8.1,-9.3,-5.4,-8.4,10,8.6,11.4,8.9,-50,-13.7,-50,-13.2,-6.1,-8.1,-5.5,-7.5,-50,-11.3,-12.7,-10.1,-1.6,-7.8,-.3,-7.2],[-11.4,-10,-12.7,-8.2,-3.1,-3.1,-2.8,-.9,-11.7,-7.3,-12.1,-5.8,3.6,3.6,-1.1,5.8,-9.4,-11.9,-10.7,-10,-8.5,-8.8,-8.2,-6.5,-13.9,-13,-12.9,-10.9,-3.1,-2.3,-3.2,-.2,-9.5,-10.8,-10.2,-8.2,-1.1,-1.3,-.8,1.2,-8.6,-7.8,-7.8,-5,9,9.5,8.9,12,-50,-13,-50,-10.3,-6.2,-7,-7.1,-5.4,-50,-9.3,-14,-8.2,-2.4,-6.3,-2.4,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,33.3,-50,30.6,-50,-50,-50,-50,-50,29.2,-50,-50,-50,-50,-50,-50,-50],[-14.8,-6.2,-14.9,-7.6,-14.6,-11.6,-13,-12.2,-14,-9,-14.1,-10.1,-13.6,-11.2,-12.4,-12.5,-8.1,2.2,-8.7,.4,-15.3,-11.3,-13.2,-13.3,-11.9,-7.2,-11.8,-7.9,-10.7,-7.4,-10.8,-8.9,-15.5,-10.3,-15.5,-12.5,-14.5,-12.1,-11.9,-12.8,-18.3,-12.7,-16.4,-14.7,-14.2,-10.4,-13.7,-13,-50,15.1,-50,13.3,-9.9,-5.8,-8.9,-7.6,-50,-1.5,-7.8,-3,-8.1,3.6,-9.4,2],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,30.6,-50,35.2,-50,-50,-50,-50,-50,28.5,-50,-50,-50,-50,-50,-50,-50],[-13.8,-7.5,-14.4,-5.1,-12.6,-11.6,-11.5,-10.1,-13.2,-9.7,-12.7,-7.4,-11.9,-11.9,-11.5,-10.2,-7.2,.9,-8.6,2.6,-14.1,-12.8,-13.3,-11,-9.7,-8.4,-11.2,-5.3,-9.3,-8.7,-9.9,-7.1,-13.9,-11.2,-14.2,-8.9,-12.9,-12.6,-12.6,-10.9,-15.4,-13.8,-14.8,-11.4,-12.8,-11.6,-13.2,-10.3,-50,13.3,-50,15.2,-8.6,-7,-8.4,-4.8,-50,-3,-7.1,-.1,-7.3,2.3,-8.7,3.9],[-7.3,-6.3,-8.9,-5.5,2.9,.2,1.5,1.2,-8.5,-2.3,-10,-1.7,-5.6,-10.5,-5.5,-9.6,-4.3,-7.9,-6.1,-7.2,2.3,-.6,.5,-0,-8.9,-11,-9.4,-9.3,-4.6,-9.4,-7.3,-8.1,-7.8,-9.8,-8.9,-9.2,2.8,.1,1.2,.8,-5.9,-6.8,-5.9,-6.3,-4.1,-7.2,-6.1,-6.2,-50,-9.9,-50,-8.6,12.5,9.4,11,9.8,-50,-4.8,-8.7,-3.5,-0,-8.6,-2.1,-7],[-10.1,-4.3,-10.8,-5.8,.1,2.3,.7,.6,-10.4,-.2,-10.8,-2,-8.8,-9.2,-8,-9.7,-6.8,-5.9,-7.5,-7,-1.4,2.2,-.9,-.4,-10.8,-7.7,-9.8,-8.8,-8.9,-7.3,-9.6,-9.1,-10.5,-8.3,-10.2,-10,-0,2.5,.7,.5,-7.5,-5.1,-7.1,-6.7,-7.4,-5.7,-8.1,-7,-50,-5.8,-50,-7,9.4,12.7,10.1,10,-50,-1.5,-11.3,-3.3,-5.4,-4.2,-5.6,-6.8],[-8.4,-6.2,-8.9,-5.9,1.8,.4,2.7,1.2,-9.1,-1.2,-8.8,-1.5,-7.2,-10.5,-4.9,-9.6,-5.7,-7.4,-5.5,-7.4,.3,-.3,1.8,-.4,-9,-8.7,-7.3,-8.9,-5.9,-9.4,-6.4,-8.7,-8.7,-9.1,-8.5,-9.4,1.4,.7,3.5,.7,-6.6,-5.3,-4.7,-5.8,-5.7,-7.5,-5.5,-7.1,-50,-8.9,-50,-8.4,11,10.1,13.2,10.2,-50,-4.2,-6.1,-3.6,-3.5,-8.4,-1.2,-6.8],[-9.1,-5.4,-10.4,-4.2,1,.5,.6,2.4,-9.6,-1.5,-10.5,-.5,-8.9,-10.5,-7.2,-8.3,-6.3,-6.9,-7.7,-5.1,-.5,.1,-.6,2.3,-11.1,-10.2,-10.5,-7,-8.3,-9.4,-9.4,-6.6,-9.6,-9.7,-10,-7.9,.7,.6,.8,2.3,-7.1,-6.5,-7.2,-5,-6.5,-7.4,-7.5,-5.4,-50,-7.6,-50,-4.8,9.8,10,10.2,12.1,-50,-3.1,-11.4,-.7,-4.6,-6.6,-4.9,-3.9],[-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,-50,29.2,-50,28.5,-50,-50,-50,-50,-50,33.3,-50,-50,-50,-50,-50,-50,-50],[-13,-7,-13.1,-8.3,-9.2,-6.5,-8.9,-7.6,-9.8,-.7,-9.2,-2.1,-12.4,-10.3,-12.4,-11.6,-9.5,-4.6,-10.4,-5.7,-13.6,-10.1,-11.4,-10.9,-6.5,-1.5,-6.2,-3.6,-12.8,-8,-12.3,-9.7,-16.5,-12.7,-15.6,-14.3,-8.7,-6,-7.1,-7.5,-9.5,-4.1,-8.4,-6.1,-11,-8.6,-11.3,-9.3,-50,-1.5,-50,-3,-4.8,-1.5,-4.2,-3.1,-50,16.4,-5.1,14.2,-10.1,-4.3,-10,-5.4],[-13.5,-16.3,-11.8,-15.5,-13.6,-15.3,-12.1,-16.1,-7.7,-13.3,-4.2,-12.6,-14.1,-16.2,-10.3,-15.4,-9.6,-11.6,-7.7,-9.8,-14.3,-17.5,-11.1,-17.2,-5.3,-7.1,-2.2,-7.1,-9.6,-11.9,-8.7,-11.4,-17.1,-20.6,-15.3,-19.9,-14.1,-14.8,-12.4,-16.5,-11.7,-12.8,-6.4,-13.4,-14.3,-15.7,-12.7,-14,-50,-7.8,-50,-7.1,-8.7,-11.3,-6.1,-11.4,-50,-5.1,18.6,-4.8,-8.6,-8.1,-4.5,-7.3],[-12.4,-8.2,-13,-5.9,-7.7,-7.8,-7.4,-5.8,-8.8,-2,-9.3,-.4,-11.6,-11.3,-11.6,-9.4,-8.9,-5.6,-10,-3.2,-11.5,-11.1,-10.5,-8.3,-6.3,-4.9,-6.7,-1.2,-10.6,-9.7,-11.3,-8,-14.8,-13.1,-15.5,-11.4,-7.5,-7.5,-7.1,-5.9,-8.4,-5.8,-8.1,-3.6,-9.9,-9.7,-10.1,-8.2,-50,-3,-50,-.1,-3.5,-3.3,-3.6,-.7,-50,14.2,-4.8,16.4,-8.9,-5.8,-8.9,-3.4],[-10.7,-13.2,-12.4,-11.6,-4.8,-8.4,-6.1,-7.2,-10.3,-11.8,-11,-11.6,2.8,-1.7,.7,-1.1,-6.2,-9.7,-7.3,-8.4,-5.3,-8.6,-6.1,-8.3,-10.5,-11.2,-9.8,-10.2,9.5,6.5,7.6,6.8,-12.1,-16,-13,-16.2,-5.2,-8.6,-7.1,-7.8,-12.5,-14.4,-12.1,-13,1.4,-3,-1.6,-2.4,-50,-8.1,-50,-7.3,-0,-5.4,-3.5,-4.6,-50,-10.1,-8.6,-8.9,13.2,-.9,9.7,-.3],[-18.1,-12.3,-19.4,-14.2,-12.2,-9.5,-11.5,-10.8,-17.9,-11.9,-18.2,-13.9,-6.4,-3.7,-6.8,-5.4,-12.8,-5.9,-13.6,-7.4,-13.7,-9.9,-12.9,-12.7,-16.2,-11.6,-15.2,-12.7,-3.2,.5,-3.3,-1.8,-18.9,-16.6,-18.8,-19.2,-12.5,-9.4,-10.6,-11.1,-17.3,-14.1,-16.2,-16,-7.9,-3.7,-7.8,-6.3,-50,3.6,-50,2.3,-8.6,-4.2,-8.4,-6.6,-50,-4.3,-8.1,-5.8,-.9,14.2,-1.8,11.6],[-11.8,-13.1,-11.5,-12,-6.2,-8.3,-5.4,-7.4,-11.8,-12.3,-11.1,-11.4,.5,-2.5,2.4,-1.6,-6.8,-9.9,-6.4,-8.9,-6.1,-8.6,-5,-7.8,-10.4,-11.6,-8.5,-9.9,8.2,6.4,8.7,6.9,-12.4,-17,-12.6,-15.8,-6.5,-8.5,-5,-7.8,-13.2,-13.6,-10.3,-13.7,-.7,-3.2,-.3,-2.4,-50,-9.4,-50,-8.7,-2.1,-5.6,-1.2,-4.9,-50,-10,-4.5,-8.9,9.7,-1.8,11.3,-.9],[-17.2,-13.3,-17.8,-11.6,-11,-11.1,-10.4,-9,-16,-12.7,-16.1,-11.1,-5.2,-5.4,-6,-3.3,-11.8,-7.3,-13.3,-5.9,-12.7,-11.9,-11.9,-9.3,-15.2,-15,-14.9,-11,-2.8,-1.8,-2.9,.4,-17.4,-18.4,-18.3,-15.9,-10.7,-11.2,-10.6,-9,-15.4,-14.8,-15.8,-13.3,-6.8,-5.9,-7.2,-3.9,-50,2,-50,3.9,-7,-6.8,-6.8,-3.9,-50,-5.4,-7.3,-3.4,-.3,11.6,-.9,14.1]],this.TRANS=[[5,0,0,4],[0,5,4,0],[0,4,5,0],[4,0,0,5]],this.CONBLO={A:0,R:1,N:2,D:3,C:4,Q:5,E:6,G:7,H:8,I:9,L:10,K:11,M:12,F:13,P:14,S:15,T:16,W:17,Y:18,V:19,B:20,Z:21,X:22,"*":23},this.CONNUCL={A:0,T:1,C:2,G:3},this.CONSCHN={AAA:0,AAC:1,AAG:2,AAT:3,ACA:4,ACC:5,ACG:6,ACT:7,AGA:8,AGC:9,AGG:10,AGT:11,ATA:12,ATC:13,ATG:14,ATT:15,CAA:16,CAC:17,CAG:18,CAT:19,CCA:20,CCC:21,CCG:22,CCT:23,CGA:24,CGC:25,CGG:26,CGT:27,CTA:28,CTC:29,CTG:30,CTT:31,GAA:32,GAC:33,GAG:34,GAT:35,GCA:36,GCC:37,GCG:38,GCT:39,GGA:40,GGC:41,GGG:42,GGT:43,GTA:44,GTC:45,GTG:46,GTT:47,TAA:48,TAC:49,TAG:50,TAT:51,TCA:52,TCC:53,TCG:54,TCT:55,TGA:56,TGC:57,TGG:58,TGT:59,TTA:60,TTC:61,TTG:62,TTT:63},this.setMethod(s),this.setSequences(e,t),this.setGap(n)}}},7983:(e,t,n)=>{"use strict";n.d(t,{HV:()=>p,QF:()=>m,pf:()=>d,uH:()=>h});var s=n(4469),r=n(3870),i=n(976),o=n(7241),a=n(4293),l=n(2997),c=n(8447);const u="substr_helm";class h{constructor(e){this.col=e[0],this.createUI()}editHelmLinkAction(){(0,a.Y)(this.inputsDiv,this.grid.root),r.tools.waitForElementInDom(this.grid.root).then((()=>{setTimeout((()=>{this.grid.cell(u,0).element.children[0].dispatchEvent(new KeyboardEvent("keydown",{key:"Enter"}))}),100)}))}updateInputs(){const e=this.units===c.r2.HELM?r.divV([this.columnsInput,this.editHelmLink]):this.units===c.r2.SEPARATOR?r.inputs([this.columnsInput,this.substructureInput,this.separatorInput]):r.inputs([this.columnsInput,this.substructureInput]);(0,a.Y)(this.inputsDiv,e)}updateNotationDiv(){this.units=this.col.getTag(i.TAGS.UNITS),this.separator=this.col.getTag(c.DX.separator);const e=this.dialog.root.getElementsByClassName("notation-text")[0];e&&(e.textContent=`Notation: ${this.units}`)}createUI(){const e=s.shell.tv.dataFrame,t={filter:e=>e.semType===i.SEMTYPE.MACROMOLECULE};this.columnsInput=r.columnInput("Column",e,this.col,(e=>{this.col=e,this.updateNotationDiv(),this.updateInputs()}),t),this.substructureInput=r.stringInput("Substructure",""),this.editHelmLink=r.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const n=i.DataFrame.create(1);n.columns.addNewString(u).init((e=>"")),n.col(u).semType=this.col.semType,n.col(u).setTag(i.TAGS.UNITS,c.r2.HELM),this.grid=n.plot.grid(),this.separatorInput=r.stringInput("Separator",this.separator),this.inputsDiv=r.div(),this.units=this.col.getTag(i.TAGS.UNITS),this.separator=this.col.getTag(c.DX.separator),this.updateInputs(),this.dialog=r.dialog("Substructure Search").add(r.divV([r.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let e,t=this.units===c.r2.HELM?n.get(u,0):this.substructureInput.value;this.units===c.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(t=t.replaceAll(this.separatorInput.value,this.separator)),e=this.units===c.r2.HELM?await m(t,this.col):d(t,this.col),this.col.dataFrame.filter.and(e)})).show()}}function d(e,t,n){const s=n?function(e,t){const n=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),s=e.charAt(0)===t,r=e.charAt(e.length-1)===t,i=e.replace(new RegExp(`^${n}|${n}$`,"g"),"");return s?r?`${n}${i}${n}`:`${n}${i}${n}|${n}${i}$`:r?`^${i}${n}|${n}${i}${n}`:`^${i}${n}|${n}${i}${n}|${n}${i}$`}(e,n):e,r=i.BitSet.create(t.length);for(let n=0;n<t.length;n++){const i=t.get(n);(i.match(s)||i===e)&&r.set(n,!0,!1)}return r}async function m(e,t){t.version!==t.temp["last-invalidated-version"]&&await p(t,!0);const n=i.Column.string("helm",1).init((t=>e));n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,c.r2.HELM);const r=await(0,o.D)(n,!0,t.temp["monomers-dict"]);return(await s.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:r.get(0),molBlockFailover:""})).get(0)}async function p(e,t){const n=i.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,l.gw)(10);const n=new Map,s=await(0,o.D)(e,t,n);e.temp["monomeric-mols"]=s,e.temp["monomers-dict"]=n,e.temp["last-invalidated-version"]=e.version}finally{n.close()}}},2568:(e,t,n)=>{"use strict";n.d(t,{n:()=>o});var s=n(4469),r=n(976),i=n(8607);function o(e,t,n=[],o=[],a=!0){const[l,c]=function(e,t,n=[],o=[]){let a=!0,l="";const c=i.g.forColumn(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)s.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(n.length>0&&!n.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==n.length?"any notation":`notation${n.length>1?"s":""} ${n.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(e,t,n,o);return a&&!l&&s.shell.warning(c),l}},3553:(e,t,n)=>{"use strict";n.d(t,{Of:()=>i,WY:()=>c,jB:()=>u,rs:()=>a});var s,r,i,o,a,l=n(8341);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(s||(s={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(i||(i={})),function(e){e.CELL_CHANGING="isCellChanging"}(o||(o={})),function(e){e.SEPARATOR="."}(a||(a={}));const c="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:l.Jy[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(e,t,n)=>{"use strict";n.d(t,{O:()=>d});var s=n(976),r=n(3870),i=n(4469),o=n(3336),a=n.n(o),l=n(8447),c=n(8607);let u=null,h=[];function d(e){let t=e??i.shell.t.columns.bySemType("Macromolecule");if(!t)throw new Error("No column with Macromolecule semantic type found");let n=c.g.forColumn(t),o=n.notation;const d=r.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),m=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=r.columnInput("Column",i.shell.t,t,(e=>{e.semType===s.SEMTYPE.MACROMOLECULE?(t=e,n=c.g.forColumn(t),o=n.notation,o===l.r2.HELM&&(y.value="/"),d.textContent="Current notation: "+o,g=m.filter((e=>e!==o)),v=r.choiceInput("Convert to",g[0],g,b),b(),u?.clear(),u?.add(r.div([d,p.root,v.root,y.root]))):p.value=t})),f=["-",".","/"];let g=m.filter((e=>e!==o));const y=r.choiceInput("Separator",f[0],f),b=()=>{v.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let v=r.choiceInput("Convert to",g[0],g,b);b(),v.onChanged((()=>{b()})),null==u&&(u=r.dialog("Convert Sequence Notation").add(r.div([d,p.root,v.root,y.root])).onOK((async()=>{const e=v.value,n=e===l.r2.SEPARATOR?y.value:void 0;await async function(e,t,n){const s=c.g.forColumn(e).convert(t,n);e.dataFrame.columns.add(s);const r=await i.functions.call("Bio:detectMacromolecule",{col:s});return r&&(s.semType=r),await i.data.detectSemanticTypes(e.dataFrame),s}(t,e,n)})).show({x:350,y:100}),h.push(u.onClose.subscribe((e=>{h.forEach((e=>{e.unsubscribe()})),h=[],u=null}))))}},6032:(e,t,n)=>{"use strict";n.d(t,{Ns:()=>o});var s=n(4469),r=n(2997),i=n(8341);async function o(e=6e4){const t=await i.lp.getDockerContainer();await async function(e,t=6e4){let n=e,i=!1;for(let o=0;o<t/200;++o){if(null===n&&(n=await s.dapi.docker.dockerContainers.find(e.id)),a(n)){i=!0;break}switch(n.status){case"stopped":await s.dapi.docker.dockerContainers.run(n.id);break;case"pending change":case"changing":break;case"error":throw new Error("Docker container error state.")}n=null,await(0,r.gw)(200)}if(!i)throw new Error("Docker container start timeout.")}(t,e)}function a(e){return"checking"===e.status||"started"===e.status}},525:(e,t,n)=>{"use strict";n.d(t,{K:()=>M});var s=n(4469),r=n(976),i=n(3870),o=n(2997),a=n(8447),l=n(8607),c=n(6098),u=n(8341),h=n(2568),d=n(3553),m=n(6032),p=n(7422),f=n(3379),g=n.n(f),y=n(7795),b=n.n(y),v=n(569),w=n.n(v),C=n(3565),A=n.n(C),S=n(9216),x=n.n(S),E=n(4589),T=n.n(E),_=n(9564),I={};async function M(e={}){return new Promise((async(t,n)=>{var a,l,h;e.clustersCol??(e.clustersCol=null),e.pepsea??(e.pepsea={}),(a=e.pepsea).method??(a.method=d.jB.pepsea.method),(l=e.pepsea).gapOpen??(l.gapOpen=d.jB.pepsea.gapOpen),(h=e.pepsea).gapExtend??(h.gapExtend=d.jB.pepsea.gapExtend);const m=e.col?.dataFrame??s.shell.t,p=e.col??m.columns.bySemType(r.SEMTYPE.MACROMOLECULE);if(null==p){const e="Multiple Sequence Alignment analysis requires a dataset with a macromolecule column.";return s.shell.warning(e),void n(new c.rE(i.divText(e)))}const f=i.choiceInput("Method",e.pepsea.method,u.Jy);f.setTooltip("Alignment method");const g=i.floatInput("Terminal gap",e?.kalign?.terminalGap??null);g.setTooltip("Penalty for opening a gap at the beginning or end of the sequence");const y=i.p(`Kalign version: ${d.WY}`,"kalign-version"),b=i.floatInput("Gap open",e.pepsea.gapOpen);b.setTooltip("Gap opening penalty at group-to-group alignment");const v=i.floatInput("Gap extend",e.pepsea.gapExtend);v.setTooltip("Gap extension penalty to skip the alignment");const w=i.inputs([b,v,g]),C=i.button("Alignment parameters",(()=>{w.hidden=!w.hidden,[b,v,g].forEach((e=>{e.root.style.removeProperty("max-width"),e.captionLabel.style.removeProperty("max-width")}))}),"Adjust alignment parameters such as penalties for opening and extending gaps");C.classList.add("msa-params-button"),w.hidden=!0,C.prepend(i.icons.settings((()=>null)));const A=[f.root.style],S=[g.root.style,y.style];let x,E=p;const T=i.columnInput("Sequence",m,p,(async e=>{if(!e||e.semType!==r.SEMTYPE.MACROMOLECULE)return M.disabled=!0,await(0,o.gw)(0),void(T.value=E);E=e,M.disabled=!1,x=await $(T.value,m,A,S,f,_,b,v,g)}),{filter:e=>e.semType===r.SEMTYPE.MACROMOLECULE});T.setTooltip("Sequences column to use for alignment");const _=i.columnInput("Clusters",m,e.clustersCol);_.nullable=!0;const I=i.dialog("MSA").add(T).add(_).add(f).add(w).add(C).add(y).onOK((async()=>{await N(T,m,x,t,n)})),M=I.getButton("OK");if(T.fireChanged(),e.col)return x=await $(e.col,m,A,S,f,_,b,v,g),void await N(T,m,x,t,n);I.show()}))}async function N(e,t,n,i,o){let a=null;const l=r.TaskBarProgressIndicator.create("Analyze for MSA ...");try{if(e.fireChanged(),e.value.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Chosen column has to be of Macromolecule semantic type");if(void 0===n)throw new Error("Invalid column format");if(a=await n(),null==a)return o("PepSeA container has not started");t.columns.add(a),await s.data.detectSemanticTypes(t),i(a)}catch(e){o(e)}finally{l.close()}}async function $(e,t,n,i,o,f,g,y,b){try{if(e.semType!==r.SEMTYPE.MACROMOLECULE)return;const s=t.columns.getUnusedName(`msa(${e.name})`);if((0,h.n)(e,e.name,[a.r2.FASTA,a.r2.SEPARATOR],[a.fb.DNA,a.fb.RNA,a.fb.PT],!1)){L(n,i,"kalign"),g.value=null,y.value=null,b.value=null;const t=l.g.forColumn(e),r=t.isFasta()?e:t.convert(a.r2.FASTA);return async()=>await(0,c.U4)(r,!1,s,f.value)}if((0,h.n)(e,e.name,[a.r2.HELM],[],!1))return L(n,i,"pepsea"),g.value??(g.value=d.jB.pepsea.gapOpen),y.value??(y.value=d.jB.pepsea.gapExtend),async()=>(await(0,m.Ns)(),(0,u.f3)(e,s,o.value,g.value,y.value,f.value));if((0,h.n)(e,e.name,[a.r2.SEPARATOR],[a.fb.UN],!1)){const t=l.g.forColumn(e).convert(a.r2.HELM);return L(n,i,"pepsea"),g.value??(g.value=d.jB.pepsea.gapOpen),y.value??(y.value=d.jB.pepsea.gapExtend),async()=>(await(0,m.Ns)(),(0,u.f3)(t,s,o.value,g.value,y.value,f.value))}return g.value=null,y.value=null,b.value=null,void L(n,i,"kalign")}catch(e){const t=e instanceof Error?e.message:e.toString();s.shell.error(t),p._package.logger.error(t)}}function L(e,t,n){if("kalign"===n){for(const t of e)t.display="none";for(const e of t)e.removeProperty("display")}else{for(const e of t)e.display="none";for(const t of e)t.removeProperty("display")}}I.styleTagTransform=T(),I.setAttributes=A(),I.insert=w().bind(null,"head"),I.domAPI=b(),I.insertStyleElement=x(),g()(_.Z,I),_.Z&&_.Z.locals&&_.Z.locals},6098:(e,t,n)=>{"use strict";n.d(t,{rE:()=>D,Xd:()=>V,U4:()=>G});var s=n(3870),r=n(976),i=n(6414),o=n.n(i),a=n(5226),l=n(8447);const c=Symbol("Comlink.proxy"),u=Symbol("Comlink.endpoint"),h=Symbol("Comlink.releaseProxy"),d=Symbol("Comlink.thrown"),m=e=>"object"==typeof e&&null!==e||"function"==typeof e,p=new Map([["proxy",{canHandle:e=>m(e)&&e[c],serialize(e){const{port1:t,port2:n}=new MessageChannel;return f(e,t),[n,[n]]},deserialize:e=>(e.start(),y(e))}],["throw",{canHandle:e=>m(e)&&d in e,serialize({value:e}){let t;return t=e instanceof Error?{isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:{isError:!1,value:e},[t,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}}]]);function f(e,t=self){t.addEventListener("message",(function n(s){if(!s||!s.data)return;const{id:r,type:i,path:o}=Object.assign({path:[]},s.data),a=(s.data.argumentList||[]).map(x);let l;try{const t=o.slice(0,-1).reduce(((e,t)=>e[t]),e),n=o.reduce(((e,t)=>e[t]),e);switch(i){case"GET":l=n;break;case"SET":t[o.slice(-1)[0]]=x(s.data.value),l=!0;break;case"APPLY":l=n.apply(t,a);break;case"CONSTRUCT":l=function(e){return Object.assign(e,{[c]:!0})}(new n(...a));break;case"ENDPOINT":{const{port1:t,port2:n}=new MessageChannel;f(e,n),l=function(e,t){return A.set(e,t),e}(t,[t])}break;case"RELEASE":l=void 0;break;default:return}}catch(e){l={value:e,[d]:0}}Promise.resolve(l).catch((e=>({value:e,[d]:0}))).then((e=>{const[s,o]=S(e);t.postMessage(Object.assign(Object.assign({},s),{id:r}),o),"RELEASE"===i&&(t.removeEventListener("message",n),g(t))}))})),t.start&&t.start()}function g(e){(function(e){return"MessagePort"===e.constructor.name})(e)&&e.close()}function y(e,t){return v(e,[],t)}function b(e){if(e)throw new Error("Proxy has been released and is not useable")}function v(e,t=[],n=function(){}){let s=!1;const r=new Proxy(n,{get(n,i){if(b(s),i===h)return()=>E(e,{type:"RELEASE",path:t.map((e=>e.toString()))}).then((()=>{g(e),s=!0}));if("then"===i){if(0===t.length)return{then:()=>r};const n=E(e,{type:"GET",path:t.map((e=>e.toString()))}).then(x);return n.then.bind(n)}return v(e,[...t,i])},set(n,r,i){b(s);const[o,a]=S(i);return E(e,{type:"SET",path:[...t,r].map((e=>e.toString())),value:o},a).then(x)},apply(n,r,i){b(s);const o=t[t.length-1];if(o===u)return E(e,{type:"ENDPOINT"}).then(x);if("bind"===o)return v(e,t.slice(0,-1));const[a,l]=C(i);return E(e,{type:"APPLY",path:t.map((e=>e.toString())),argumentList:a},l).then(x)},construct(n,r){b(s);const[i,o]=C(r);return E(e,{type:"CONSTRUCT",path:t.map((e=>e.toString())),argumentList:i},o).then(x)}});return r}function w(e){return Array.prototype.concat.apply([],e)}function C(e){const t=e.map(S);return[t.map((e=>e[0])),w(t.map((e=>e[1])))]}const A=new WeakMap;function S(e){for(const[t,n]of p)if(n.canHandle(e)){const[s,r]=n.serialize(e);return[{type:"HANDLER",name:t,value:s},r]}return[{type:"RAW",value:e},A.get(e)||[]]}function x(e){switch(e.type){case"HANDLER":return p.get(e.name).deserialize(e.value);case"RAW":return e.value}}function E(e,t,n){return new Promise((s=>{const r=new Array(4).fill(0).map((()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16))).join("-");e.addEventListener("message",(function t(n){!n.data||!n.data.id||n.data.id!==r||(e.removeEventListener("message",t),s(n.data))})),e.start&&e.start(),e.postMessage(Object.assign({id:r},t),n)}))}const T="(function(){"use strict";const $=Symbol("Comlink.proxy"),A=Symbol("Comlink.endpoint"),R=Symbol("Comlink.releaseProxy"),y=Symbol("Comlink.thrown"),_=e=>typeof e=="object"&&e!==null||typeof e=="function",L={canHandle:e=>_(e)&&e[$],serialize(e){const{port1:r,port2:i}=new MessageChannel;return w(e,r),[i,[i]]},deserialize(e){return e.start(),C(e)}},O={canHandle:e=>_(e)&&y in e,serialize({value:e}){let r;return e instanceof Error?r={isError:!0,value:{message:e.message,name:e.name,stack:e.stack}}:r={isError:!1,value:e},[r,[]]},deserialize(e){throw e.isError?Object.assign(new Error(e.value.message),e.value):e.value}},E=new Map([["proxy",L],["throw",O]]);function w(e,r=self){r.addEventListener("message",function i(s){if(!s||!s.data)return;const{id:o,type:a,path:n}=Object.assign({path:[]},s.data),u=(s.data.argumentList||[]).map(m);let l;try{const c=n.slice(0,-1).reduce((d,h)=>d[h],e),f=n.reduce((d,h)=>d[h],e);switch(a){case"GET":l=f;break;case"SET":c[n.slice(-1)[0]]=m(s.data.value),l=!0;break;case"APPLY":l=f.apply(c,u);break;case"CONSTRUCT":{const d=new f(...u);l=z(d)}break;case"ENDPOINT":{const{port1:d,port2:h}=new MessageChannel;w(e,h),l=N(d,[d])}break;case"RELEASE":l=void 0;break;default:return}}catch(c){l={value:c,[y]:0}}Promise.resolve(l).catch(c=>({value:c,[y]:0})).then(c=>{const[f,d]=S(c);r.postMessage(Object.assign(Object.assign({},f),{id:o}),d),a==="RELEASE"&&(r.removeEventListener("message",i),F(r))})}),r.start&&r.start()}function T(e){return e.constructor.name==="MessagePort"}function F(e){T(e)&&e.close()}function C(e,r){return b(e,[],r)}function p(e){if(e)throw new Error("Proxy has been released and is not useable")}function b(e,r=[],i=function(){}){let s=!1;const o=new Proxy(i,{get(a,n){if(p(s),n===R)return()=>g(e,{type:"RELEASE",path:r.map(u=>u.toString())}).then(()=>{F(e),s=!0});if(n==="then"){if(r.length===0)return{then:()=>o};const u=g(e,{type:"GET",path:r.map(l=>l.toString())}).then(m);return u.then.bind(u)}return b(e,[...r,n])},set(a,n,u){p(s);const[l,c]=S(u);return g(e,{type:"SET",path:[...r,n].map(f=>f.toString()),value:l},c).then(m)},apply(a,n,u){p(s);const l=r[r.length-1];if(l===A)return g(e,{type:"ENDPOINT"}).then(m);if(l==="bind")return b(e,r.slice(0,-1));const[c,f]=M(u);return g(e,{type:"APPLY",path:r.map(d=>d.toString()),argumentList:c},f).then(m)},construct(a,n){p(s);const[u,l]=M(n);return g(e,{type:"CONSTRUCT",path:r.map(c=>c.toString()),argumentList:u},l).then(m)}});return o}function D(e){return Array.prototype.concat.apply([],e)}function M(e){const r=e.map(S);return[r.map(i=>i[0]),D(r.map(i=>i[1]))]}const P=new WeakMap;function N(e,r){return P.set(e,r),e}function z(e){return Object.assign(e,{[$]:!0})}function S(e){for(const[r,i]of E)if(i.canHandle(e)){const[s,o]=i.serialize(e);return[{type:"HANDLER",name:r,value:s},o]}return[{type:"RAW",value:e},P.get(e)||[]]}function m(e){switch(e.type){case"HANDLER":return E.get(e.name).deserialize(e.value);case"RAW":return e.value}}function g(e,r,i){return new Promise(s=>{const o=U();e.addEventListener("message",function a(n){!n.data||!n.data.id||n.data.id!==o||(e.removeEventListener("message",a),s(n.data))}),e.start&&e.start(),e.postMessage(Object.assign({id:o},r),i)})}function U(){return new Array(4).fill(0).map(()=>Math.floor(Math.random()*Number.MAX_SAFE_INTEGER).toString(16)).join("-")}const W=async()=>WebAssembly.validate(new Uint8Array([0,97,115,109,1,0,0,0,1,5,1,96,0,1,123,3,2,1,0,10,10,1,8,0,65,0,253,15,253,98,11])),x="eager",k="lazy",j={ssw:["simd"],minimap2:["simd"]},t={tools:[],config:{},files:[],base:{},fs:{},async init(){if(t.tools.length===0)throw"Expecting at least 1 tool.";if(new Set(t.tools.map(r=>`${r.tool}/${r.program||r.tool}`)).size!==t.tools.length)throw"Found duplicate tools; can only have each tool/program combination at most once.";if(t.base=t.tools.find(r=>r.reinit!==!0),!t.base)throw"Could not find a tool with `reinit: false` to use as the base module. To fix this issue, include the tool `base/1.0.0` when initializing Aioli.";return t.base.isBaseModule=!0,await this._setup(t.base),await this._initModules(),t._log("Ready"),!0},async _initModules(){await Promise.all(t.tools.map(this._setup)),await this._setupFS()},mount(e=[]){const r=`${t.config.dirShared}${t.config.dirData}`,i=`${t.config.dirShared}${t.config.dirMounted}`;let s=[],o=[],a=[];!Array.isArray(e)&&!(e instanceof FileList)&&(e=[e]),t._log(`Mounting ${e.length} files`);for(let n of e){if(n instanceof File||(n==null?void 0:n.data)instanceof Blob&&n.name||typeof(n==null?void 0:n.data)=="string"&&n.name)typeof(n==null?void 0:n.data)=="string"&&(n.data=new Blob([n.data],{type:"text/plain"})),s.push(n);else if(n.name&&n.url)o.push(n);else if(typeof n=="string"&&n.startsWith("http"))n={url:n,name:n.split("//").pop().replace(/\//g,"-")},o.push(n);else throw'Cannot mount file(s) specified. Must be a File, Blob, a URL string, or { name: "file.txt", data: "string" }.';a.push(n.name)}try{t.fs.unmount(i)}catch{}for(let n of o)t.fs.createLazyFile(r,n.name,n.url,!0,!0);return t.files=t.files.concat(s),t.base.module.FS.mount(t.base.module.WORKERFS,{files:t.files.filter(n=>n instanceof File),blobs:t.files.filter(n=>(n==null?void 0:n.data)instanceof Blob)},i),s.map(n=>{const u=`${i}/${n.name}`,l=`${r}/${n.name}`;try{t.fs.unlink(l)}catch{}t._log(`Creating symlink: ${l} --> ${u}`),t.fs.symlink(u,l)}),a.map(n=>`${r}/${n}`)},async exec(e,r=null){if(t._log(`Executing %c${e}%c args=${r}`,"color:darkblue; font-weight:bold",""),!e)throw"Expecting a command";let i=e;r==null&&(r=e.split(" "),i=r.shift());const s=t.tools.find(a=>{var u;let n=i;return((u=a==null?void 0:a.features)==null?void 0:u.simd)===!0&&(n=`${n}-simd`),a.program==n});if(s==null)throw`Program ${i} not found.`;s.stdout="",s.stderr="",s.loading==k&&(s.loading=x,await this._initModules());try{s.module.callMain(r)}catch(a){console.error(a)}try{s.module.FS.close(s.module.FS.streams[1]),s.module.FS.close(s.module.FS.streams[2])}catch{}s.module.FS.streams[1]=s.module.FS.open("/dev/stdout","w"),s.module.FS.streams[2]=s.module.FS.open("/dev/stderr","w");let o={stdout:s.stdout,stderr:s.stderr};if(t.config.printInterleaved&&(o=s.stdout),s.reinit===!0){const a=t.base.module.FS.cwd();Object.assign(s,s.config),s.ready=!1,await this.init(),s.isBaseModule&&this.mount(),this.cd(a)}return o},cat(e){return t._fileop("cat",e)},ls(e){return t._fileop("ls",e)},download(e){return t._fileop("download",e)},pwd(){return t.fs.cwd()},cd(e){for(let r of t.tools)!r.module||r.module.FS.chdir(e)},mkdir(e){return t.fs.mkdir(e),!0},read({path:e,length:r,flag:i="r",offset:s=0,position:o=0}){const a=t.fs.open(e,i),n=new Uint8Array(r);return t.fs.read(a,n,s,r,o),t.fs.close(a),n},write({path:e,buffer:r,flag:i="w+",offset:s=0,position:o=0}){const a=t.fs.open(e,i);t.fs.write(a,r,s,r.length,o),t.fs.close(a)},_stdinTxt:"",_stdinPtr:0,get stdin(){return t._stdinTxt},set stdin(e=""){t._log(`Setting stdin to %c${e}%c`,"color:darkblue",""),t._stdinTxt=e,t._stdinPtr=0},async _setup(e){if(e.ready)return;if(t._log(`Setting up ${e.tool} (base = ${e.isBaseModule===!0})...`),e.config=Object.assign({},e),e.urlPrefix||(e.urlPrefix=`${t.config.urlCDN}/${e.tool}/${e.version}`),e.program||(e.program=e.tool),e.features||(e.features={},(j[e.program]||[]).includes("simd")&&(await W()?(e.program+="-simd",e.features.simd=!0):t._log(`WebAssembly SIMD is not supported in this browser; will load non-SIMD version of ${e.program}.`))),e.isBaseModule&&(e.loading=x),e.loading===k){t._log(`Will lazy-load ${e.tool}; skipping initialization.`);return}self.importScripts(`${e.urlPrefix}/${e.program}.js`),e.module=await Module({thisProgram:e.program,locateFile:(i,s)=>`${e.urlPrefix}/${i}`,stdin:()=>t._stdinPtr<t.stdin.length?t.stdin.charCodeAt(t._stdinPtr++):(t.stdin="",null),print:i=>e.stdout+=`${i}
`,printErr:t.config.printInterleaved?i=>e.stdout+=`${i}
`:i=>e.stderr+=`${i}
`});const r=e.module.FS;e.isBaseModule?(t._log(`Setting up ${e.tool} with base module filesystem...`),r.mkdir(t.config.dirShared,511),r.mkdir(`${t.config.dirShared}/${t.config.dirData}`,511),r.mkdir(`${t.config.dirShared}/${t.config.dirMounted}`,511),r.chdir(`${t.config.dirShared}/${t.config.dirData}`),t.fs=r):(t._log(`Setting up ${e.tool} with filesystem...`),r.mkdir(t.config.dirShared),r.mount(e.module.PROXYFS,{root:t.config.dirShared,fs:t.fs},t.config.dirShared),r.chdir(t.fs.cwd())),e.stdout="",e.stderr="",e.ready=!0},async _setupFS(){const e=t.fs;for(let r of t.tools){if(!r.ready)continue;const i=r.module.FS,s=`/${r.tool}`,o=`${t.config.dirShared}${s}`;!i.analyzePath(s).exists||e.analyzePath(o).exists||(t._log(`Mounting ${s} onto ${t.base.tool} filesystem at ${o}`),e.mkdir(o),e.mount(t.base.module.PROXYFS,{root:s,fs:i},o))}},_fileop(e,r){t._log(`Running ${e} ${r}`);const i=t.fs.analyzePath(r);if(!i.exists)return t._log(`File ${r} not found.`),!1;switch(e){case"cat":return t.fs.readFile(r,{encoding:"utf8"});case"ls":return t.fs.isFile(i.object.mode)?t.fs.stat(r):t.fs.readdir(r);case"download":const s=new Blob([this.cat(r)]);return URL.createObjectURL(s)}return!1},_log(e){if(!t.config.debug)return;let r=[...arguments];r.shift(),console.log(`%c[WebWorker]%c ${e}`,"font-weight:bold","",...r)}};w(t)})();
",_=typeof window<"u"&&window.Blob&&new Blob([atob(T)],{type:"text/javascript;charset=utf-8"});function I(){const e=_&&(window.URL||window.webkitURL).createObjectURL(_);try{return e?new Worker(e):new Worker("data:application/javascript;base64,"+T)}finally{e&&(window.URL||window.webkitURL).revokeObjectURL(e)}}const M={urlCDN:"https://biowasm.com/cdn/v3",urlCDNStg:"https://stg.biowasm.com/cdn/v3",dirShared:"/shared",dirMounted:"/mnt",dirData:"/data",printInterleaved:!0,callback:null,debug:!1,env:"prd"};class N{constructor(e,t={}){if(null==e)throw"Expecting array of tools as input to Aioli constructor.";return Array.isArray(e)||(e=[e]),t=Object.assign({},M,t),e=e.map(this._parseTool),"stg"===t.env&&(t.urlCDN=t.urlCDNStg),this.tools=e,this.config=t,null!=this.config.callback&&(this.callback=this.config.callback),delete this.config.callback,this.init()}async init(){const e=new I;this.callback&&(e.onmessage=e=>{"biowasm"===e.data.type&&this.callback(e.data.value)});const t=y(e);return t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var $=n(850);class L{static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,$.hu)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}L.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class P{constructor(e="categorial"){this.aa2num=L.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,n=e.length;const s=["NH2","COOH"];if(e.startsWith(s[0])){const n=s[0].length;(0,$.hu)("-"==e[n],`Wrong sequence format: ${s[0]} without following '-' in '${e}'.`),t=n}if(e.endsWith(s[1])){const t=s[1].length+1;(0,$.hu)("-"==e[n-t],`Wrong sequence format: ${s[1]} without '-' precending in '${e}'.`),n-=t}return e.substring(t,n)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return P._dropDefises(P._truncateSequence(e))}encode(e){const t=e.length,n=new Array(t).fill(0);for(let s=0;s<t;++s){const t=e[s];(0,$.hu)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),n[s]=this.encodeLettter(t)}return n}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let n=0;n<e.length;++n){const s=e[n];(0,$.hu)(s in this.num2aa,`Unknown code '${s}' found in vector '${e}'`),t+=this.num2aa[s]}return t}}var R=n(3553);const O="input.fa",k="result.fasta";class D extends Error{constructor(e,t){super(e.innerText,t),this.element=e}}function F(e){return e.reduce(((e,t,n)=>e+`>sample${n+1}\n${t}\n`),"")}async function G(e,t=!1,n="",s=null,i,o,c){let u=e.toList();t&&(u=u.map((e=>P.clean(e).replace(/\-/g,""))));const h=e.length;s??(s=r.Column.string("Clusters",h).init("0")),s.type!=r.COLUMN_TYPE.STRING&&(s=s.convertTo(r.TYPE.STRING)),s.compact();const d=s.categories,m=s.getRawData(),p=new Array(d.length),f=new Array(d.length);for(let e=0;e<h;++e){const t=m[e];(p[t]??(p[t]=[])).push(u[e]),(f[t]??(f[t]=[])).push(e)}V(f,d);const g=await new N(["base/1.0.0",{tool:"kalign",version:R.WY,reinit:!0}]),y=r.Column.string(n,h);for(let e=0;e<d.length;++e){const t=F(p[e]);await g.fs.writeFile(O,t);const n=`${void 0!==i?` --gpo ${i}`:""}${void 0!==o?` --gpe ${o}`:""}${void 0!==c?` --tgpe ${c}`:""}`,s=await g.exec(`kalign ${O} -f fasta -o ${k}${n}`);console.warn(s);const r=await g.cat(k);if(!r){const e=B(s,1);throw new Error(e)}const l=new a.i(r).sequencesArray,u=f[e];for(let e=0;e<l.length;++e)y.set(u[e],l[e])}const b=e.getTag(r.TAGS.UNITS),v=e.getTag(l.DX.alphabet);return y.setTag(r.TAGS.UNITS,b),y.setTag(l.DX.aligned,"SEQ.MSA"),y.setTag(l.DX.alphabet,v),y.semType=r.SEMTYPE.MACROMOLECULE,y}function B(e,t){const n=[],s=/^.+ERROR : (.+)$/gm;let r;for(;null!=(r=s.exec(e))&&(void 0===t||n.length<t);)n.push(r[1]);return n.join("\n")}function V(e,t){const n=e.map(((e,t)=>[e,t])).filter((([e,t])=>1==e.length)).map((([e,t])=>t));if(n.length>0){const e=s.div([s.divText(`MSA analysis is not available on single sequence clusters #${n.length}:`),...o()(n).take(3).map((e=>{let r=t[e];return r.length>25&&(r=r.slice(0,25)+"..."),s.divText(`"${r}"${e<n.length-1?", ":"."}`)})).toArray(),...n.length>3?[s.divText("...")]:[]]);throw new D(e)}}},8341:(e,t,n)=>{"use strict";n.d(t,{Jy:()=>u,f3:()=>d,lp:()=>c});var s=n(4469),r=n(976),i=n(8447),o=n(6098),a=n(3553),l=n(7422);const c=new class{constructor(){this.dcName="bio"}async getDockerContainer(){return await s.dapi.docker.dockerContainers.filter(this.dcName).first()}},u=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],h=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function d(e,t,n="ginsi",s=1.53,l=0,u=null,d){const p=await c.getDockerContainer();if("started"!==p.status&&"checking"!==p.status)throw new Error("PepSeA container has not started yet");const f=e.length;u??(u=r.Column.int("Clusters",f).init(0)),u.type!=r.COLUMN_TYPE.STRING&&(u=u.convertTo(r.TYPE.STRING));const g=u.categories,y=u.getRawData(),b=new Array(g.length),v=new Array(g.length);for(let t=0;t<f;++t){const n=y[t],s=g[n];if(""===s)continue;const r=g.indexOf(s),i=e.get(t);i&&((b[r]??(b[r]=[])).push({ID:t.toString(),HELM:i}),(v[n]??(v[n]=[])).push(t))}(0,o.Xd)(v,g);const w=new Array(f);for(const e of b){const t=(await m(p.id,e,n,s,l,d)).Alignment;for(const e of t)w[parseInt(e.ID)]=Object.entries(e).filter((e=>!h.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(a.rs.SEPARATOR)}const C=r.Column.fromStrings(t,w);return C.setTag(r.TAGS.UNITS,i.r2.SEPARATOR),C.setTag(i.DX.separator,a.rs.SEPARATOR),C.setTag(i.DX.aligned,"SEQ.MSA"),C.setTag(i.DX.alphabet,i.fb.UN),C.setTag(i.DX.alphabetIsMultichar,"true"),C.semType=r.SEMTYPE.MACROMOLECULE,C}async function m(e,t,n,r,i,o){const a={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},c=`/align?method=${n}&gap_open=${r}&gap_extend=${i}`;let u;if("fetchProxy"in s.dapi.docker.dockerContainers){const t=window.performance.now(),n=await s.dapi.docker.dockerContainers.fetchProxy(e,c,a),r=window.performance.now();l._package.logger.debug(`Bio: requestAlignedObjects() dockerContainers.fetchProxy(), ET: ${r-t} ms`);const i="application/json"===n.headers.get("content-type");if(!n.ok&&i){const e=await n.json(),t=e["pepsea-error"];if(t)throw new Error(`PepSeA error: ${t}`);const s=e["datagrok-error"];if(s)throw new Error(`Datagrok error: ${s}`);throw new Error(n.statusText)}if(!n.ok&&!i){const e=await n.text();throw new Error(`Error: ${e}`)}if(!i){const e=await n.text();throw new Error(`Error: PepSeA expected JSON response, got '${e}'.`)}u=await n.json()}else{const t=await s.dapi.docker.dockerContainers.request(e,c,a);if(!t)throw new Error("Empty response");u=JSON.parse(t);const n=u["pepsea-error"];if(n)throw new Error(`PepSeA error: ${n}`);const r=u["datagrok-error"];if(r)throw new Error(`Datagrok error: ${r}`)}if("pepsea-stderr"in u){const e=u["pepsea-stderr"];o?.warning(e)}return u}},9943:(e,t,n)=>{"use strict";n.d(t,{C2:()=>u});var s=n(976),r=n(3870),i=n(4469),o=n(6414),a=n.n(o),l=n(8607);const c=60;function u(){const e=i.shell.tv.grid,t=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>!!e.column&&e.column.semType!==s.SEMTYPE.MACROMOLECULE)).toArray(),n=t.find((e=>-1!==e.name.toLowerCase().indexOf("id"))),o=n?[n.name]:[],u=r.multiChoiceInput("Seq id columns",o,t.map((e=>e.name))),d=a().count(0).take(e.columns.length).map((t=>e.columns.byIndex(t))).filter((e=>{const t=e.column;return!(!t||t.semType!==s.SEMTYPE.MACROMOLECULE)&&l.g.forColumn(t).isFasta()})).toArray(),m=d.length>0?d[0].name:[],p=r.choiceInput("Seq column",m,d.map((e=>e.name))),f=r.intInput("FASTA line width",c);r.dialog({title:"Save as FASTA"}).add(r.inputs([u,p,f])).onOK((()=>{const t=u.value?u.value.map((t=>e.columns.byName(t).column)):[],n=p.value?e.columns.byName(p.value).column:null,s=f.value??c;n||i.shell.warning("Seq column is mandatory to save as FASTA.");const r=function(e,t,n=c,s="\n"){const r=l.g.forColumn(t),i=[];for(let o=0;o<t.length;o++){const t=e.map((e=>e.get(o).toString())).join("|"),a=h(r.getSplitted(o),n);i.push(`>${t}${s}`);for(const e of a)i.push(`${e}${s}`)}return"".concat(...i)}(t,n,s),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(r)}`),o.setAttribute("download",`${e.dataFrame.name}.fasta`),o.click()})).show()}function h(e,t=c){let n=0;const s=e.length,r=[];for(;n<s;){const s=a()(e.originals).slice(n,n+t).toArray(),i=s.map((e=>e.length>1?`[${e}]`:e)).reduce(((e,t)=>e+t),"");r.push(i),n+=s.length}return r}},9416:(e,t,n)=>{"use strict";n.d(t,{n:()=>u});var s=n(4469),r=n(976),i=n(2997),o=n(2568),a=n(8457),l=n(3553),c=n(1821);async function u(e,t){if(await(0,i.gw)(10),!(0,o.n)(t,"Sequence space"))return e;const n=(0,a.O)(t);n.name="splitToMonomers";const u=t.dataFrame;for(const e of n.columns)e.semType=l.Of.MONOMER,e.setTag(c.DX.alphabet,t.getTag(c.DX.alphabet));const h=/(\d+)(?: \((\d+)\))?/,d=e=>{h.lastIndex=0;const t=e.match(h);return t?`${t[1]} (${parseInt(t[2]??"0")+1})`:e};for(let e=0;e<n.columns.length;e++){const s=n.columns.byIndex(e);s.semType=l.Of.MONOMER,s.setTag(c.DX.alphabet,t.getTag(c.DX.alphabet));const r=100;let i=0;for(;u.columns.byName(s.name)&&i<r;)s.name=d(s.name),i++;u.columns.add(s)}await s.data.detectSemanticTypes(u);for(let e=0;e<n.columns.length;e++){const t=n.columns.byIndex(e);t.setTag(r.TAGS.CELL_RENDERER,"Monomer"),t.setTag(".use-as-filter","false")}return u}},4293:(e,t,n)=>{"use strict";n.d(t,{B:()=>i,Y:()=>o});var s=n(4469),r=n(976);function i(){const e=s.shell.t.columns.bySemTypeAll(r.SEMTYPE.MACROMOLECULE);if(null!==e)return e;s.shell.error("Current table does not contain macromolecules")}function o(e,t){e.innerHTML="",e.append(t)}},8415:(e,t,n)=>{"use strict";n.d(t,{bo:()=>v,OZ:()=>_});var s=n(4469),r=n(3870),i=n(976),o=n(3336),a=n.n(o),l=n(6414),c=n.n(l),u=n(701),h=n(8607),d=n(8447),m=n(9298);function p(e){var t;return"string"==typeof e||e instanceof String?e:("object"==typeof e||e instanceof Object)&&"$thrownJsError"in e?p(e.$thrownJsError):e instanceof Error?null!==(t=e.stack)&&void 0!==t?t:e.message:e.toString()}var f=n(6286),g=n(2997),y=n(172);var b,v,w=n(8770),C=n(7422);HTMLCanvasElement.prototype.getCursorPosition=function(e,t){const n=this.getBoundingClientRect();return new i.Point((e.clientX-n.left)*t,(e.clientY-n.top)*t)},i.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class A{constructor(e=0,t){this.valueList=null,this.valueIdx=0,this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class S{get label(){return this._label?this._label:this.name}constructor(e,t,n,s){this.pos=e,this.name=t,this.sumRowCount=0,this._freqs=n??{},s?.sumRowCount&&(this.sumRowCount=s.sumRowCount),s?.sumValueForHeight&&(this.sumPlotValue=s.sumValueForHeight),s?.label&&(this._label=s.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new A),t}aggregate(e){const t=function(e){return t=>{const n=function(e){let t;const n="agg";return t=e instanceof Float32Array?i.Column.fromFloat32Array(n,e):e instanceof Int32Array?i.Column.fromInt32Array(n,e):i.Column.fromList(i.COLUMN_TYPE.FLOAT,n,e),t}(t);return n.aggregate(e)}}(e);for(const[e,n]of Object.entries(this._freqs))n.aggregate(t)}getMinValue(){return Math.min(...Object.values(this._freqs).map((e=>e.value)))}calcPlotValue(e){for(const t of Object.values(this._freqs))t.plotValue=t.value-e}calcHeights(e){this.sumPlotValue=0;for(const e of Object.values(this._freqs))this.sumPlotValue+=e.plotValue;if(this.sumPlotValueForHeight=0,e===m.ES.Entropy){const e=Object.keys(this._freqs).length,t=.01*this.sumPlotValue,n=t/e;for(const e of Object.values(this._freqs)){const s=(e.plotValue+n)/(this.sumPlotValue+t);this.sumPlotValueForHeight+=-s*Math.log2(s)}}else if(e===m.ES.full)for(const[e,t]of Object.entries(this._freqs)){const e=t.plotValue/this.sumPlotValue;this.sumPlotValueForHeight+=e}}calcScreen(e,t,n,s,r,o,a,l,c){const u=s===m.ES.Entropy?n*(r-this.sumPlotValueForHeight)/r:n;let h=c*l+(n-u-1);const d=Object.entries(this._freqs).sort(((e,t)=>e[0]!==f.G2&&t[0]!==f.G2?t[1].value-e[1].value:e[0]===f.G2&&t[0]===f.G2?0:e[0]===f.G2?-1:1));for(const[n,s]of d){const n=u*s.plotValue/this.sumPlotValue;s.bounds=new i.Rect((e-t)*l*o,h,a*l,n),h+=n}}render(e,t,n,s,r){for(const[i,o]of Object.entries(this._freqs))if(i!==f.G2){const a=(0,d.GU)(i,5),l=o.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=r.get(i)??r.get("other"),e.textAlign="left",e.font=t;const u=e.measureText(a);e.setTransform(l.width/u.width,0,0,l.height/s,c,l.top),e.fillText(a,0,-n)}}getMonomerAt(e,t){const n=Object.entries(this._freqs).find((([n,s])=>s.bounds.contains(e,t)));return n?n[0]:void 0}buildCompositionTable(e){if("-"in this._freqs)throw new Error("Unexpected monomer symbol '-'.");return(0,w._)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(v||(v={}));const x=m.vS;var E;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(E||(E={}));const T=new class{constructor(){this.render=20}};class _ extends i.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===m.dE.AUTO&&!0===this.seqHandler.getAlphabetIsMultichar()||this.positionMarginState===m.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.initialized=!1,this.palette=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewerId=++_.viewerCounter,this.setDataInProgress=!1,this.viewSubs=[],this.lastSize={width:-1,height:-1},this._onSizeChanged=new u.Subject,this._onFreqsCalculated=new u.Subject,this._onLayoutCalculated=new u.Subject,this.requestedRenderLevel=E.Freqs,this.renderRequest=new u.Subject,this._onRendered=new u.Subject,this.textBaseline="top",this.seqHandler=null,this.sequenceColumnName=this.string(v.sequenceColumnName,x.sequenceColumnName,{category:b.DATA});const e=[i.AGG.KEY,i.AGG.PIVOT,i.AGG.MISSING_VALUE_COUNT,i.AGG.SKEW,i.AGG.KURT,i.AGG.SELECTED_ROWS_COUNT],t=Object.values(i.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(v.valueAggrType,x.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(v.valueColumnName,x.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(v.startPositionName,x.startPositionName,{category:b.DATA}),this.endPositionName=this.string(v.endPositionName,x.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(v.skipEmptySequences,x.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(v.skipEmptyPositions,x.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(v.shrinkEmptyTail,x.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(v.backgroundColor,x.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(v.positionHeight,x.positionHeight,{category:b.STYLE,choices:Object.values(m.ES)}),this._positionWidth=this.positionWidth=this.float(v.positionWidth,x.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(v.verticalAlignment,x.verticalAlignment,{category:b.LAYOUT,choices:Object.values(m.vw)}),this.horizontalAlignment=this.string(v.horizontalAlignment,x.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(m.iD)}),this.fixWidth=this.bool(v.fixWidth,x.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(v.fitArea,x.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(v.minHeight,x.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(v.maxHeight,x.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(v.showPositionLabels,x.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(v.positionMarginState,x.positionMarginState,{category:b.LAYOUT,choices:Object.values(m.dE)});let n=0;"auto"===this.positionMarginState&&(n=4),this.positionMargin=this.int(v.positionMargin,n,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(v.filterSource,x.filterSource,{category:b.BEHAVIOR,choices:Object.values(m.Ct)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.c(C._package.logger)}toLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.toLog()}.setData()`;C._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),C._package.logger.debug(`${e}, out`)}async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,C._package.logger.debug(`${this.toLog()}.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";C._package.logger.debug(`${this.toLog()}.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(i.debounce(this.renderRequest,T.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,u.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(E.Freqs,"buildView"),C._package.logger.debug(`${this.toLog()}.buildView() end`)}rootOnSizeChanged(e){const t={width:e.target.clientWidth,height:e.target.clientHeight};this.lastSize.width==t.width&&this.lastSize.height==t.height||(C._package.logger.debug(`${this.toLog()}.rootOnSizeChanged(), ${JSON.stringify(t)}, start `),this.render(E.Layout,"rootOnSizeChanged")),this.lastSize=t}updateEditors(){this.props.getProperty(v.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.seqHandler=h.g.forColumn(this.seqCol),this.palette=(0,d.dQ)(this.seqCol),this.render(E.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.seqHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case m.Ct.Filtered:e=this.dataFrame.filter;break;case m.Ct.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=m.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${n}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=n*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),s=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${s}px`,this.canvas.style.height=`${n}px`,this.host.style.width=`${s}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${s+6}px`),this.host.style.width=`${this.host}px`;const r=t>s;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=s*e,this.canvas.height=n*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,n=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),s=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/n,i=Math.max(1,Math.min(s,r));this._positionWidth=this.positionWidth*i,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=i*n,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=o>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const n=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+n,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-n),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case v.sequenceColumnName:this.updateSeqCol();break;case v.sequenceColumnName:case v.startPositionName:case v.endPositionName:case v.filterSource:case v.shrinkEmptyTail:case v.skipEmptyPositions:case v.positionHeight:case v.valueColumnName:case v.valueAggrType:this.render(E.Freqs,`onPropertyChanged( ${e.name} )`);break;case v.minHeight:case v.maxHeight:case v.positionWidth:case v.showPositionLabels:case v.fixWidth:case v.fitArea:case v.horizontalAlignment:case v.verticalAlignment:case v.positionMargin:case v.positionMarginState:this.render(E.Layout,`onPropertyChanged(${e.name})`);break;case v.backgroundColor:this.render(E.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){C._package.logger.debug(`${this.toLog()}.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.toLog()}.detach()`;C._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),C._package.logger.debug(`${e}, out`)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const n=e.x,s=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[s];if(!r)return[null,null,null];const i=r.getMonomerAt(n,e.y);return void 0===i?[r,null,null]:[r,i,r.getFreq(i)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>!e.hasMonomer(f.G2)||e.getFreq(f.G2).rowCount!==e.sumRowCount)).toArray())}render(e,t){C._package.logger.debug(`${this.toLog()}.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(C._package.logger.debug(`${this.toLog()}.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,n=this.showPositionLabels?12:0;if(e>=E.Freqs&&(()=>{if(C._package.logger.debug(`${this.toLog()}.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.seqCol.getTag(d.DX.positionNames),t=this.seqCol.getTag(d.DX.positionLabels);let n;!e&&this.endPositionName&&/\d+/.test(this.endPositionName)?n=Number(this.endPositionName):e&&this.endPositionName&&(n=e.split(d.CI).indexOf(this.endPositionName),n=-1!==n?n:void 0);const s=this.getFilter(),r=0===s.trueCount?this.seqHandler.maxLength:c().count(0).take(this.seqHandler.length).map((e=>{const t=this.seqHandler.getSplitted(e,n);return s.get(e)&&t?t.length:0})).reduce(((e,t)=>Math.max(e,t)),0);this.positionNames=e?e.split(d.CI).map((e=>e.trim())):[...Array(r).keys()].map((e=>`${e+1}`)),this.positionLabels=t?t.split(d.CI).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):r-1;const o=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.seqHandler=h.g.forColumn(this.seqCol);const a=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(a);for(let e=0;e<o;e++){const t=this.positionNames[this.startPosition+e],n=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new S(this.startPosition+e,t,{},{label:n})}const l=this.dataFrame.rowCount;for(let e=0;e<o;++e){for(let t=0;t<l;++t)if(s.get(t)){const n=this.seqHandler.getSplitted(t),s=e<n.length?n.getCanonical(this.startPosition+e):this.seqHandler.defaultGapOriginal,r=this.seqHandler.defaultGapOriginal===s?f.G2:s,i=this.positions[e],o=i.getFreq(r);++i.sumRowCount,o.value=++o.rowCount}if(this.valueAggrType===i.AGG.TOTAL_COUNT)continue;let t=null;try{t=this.dataFrame.getCol(this.valueColumnName),t.matches("numerical")||(t=null)}catch{t=null}if(t){for(let n=0;n<l;++n)if(s.get(n)){const s=this.seqHandler.getSplitted(n).getCanonical(this.startPosition+e),r=t.get(n);this.positions[e].getFreq(s).push(r)}this.positions[e].aggregate(this.valueAggrType)}}const u=this.valueAggrType===i.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<o;++e)this.positions[e].calcPlotValue(u),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),o=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=E.Layout&&((e,t,n,r)=>{C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), start `);const o=this.canvas.height-r*n;let a;if(this.valueAggrType===i.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==m.ES.Entropy&&null==e&&s.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let s=e;s<=t;++s)s in this.positions?this.positions[s].calcScreen(s,this.slider.min,o,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,n,r):C._package.logger.warning(`${this.toLog()}.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${s}`);C._package.logger.debug(`${this.toLog()}.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,o,window.devicePixelRatio,n);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=i.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,n>0&&this.positions.length>0&&function(e,t,n,s,r,i,o,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(o);t<=Math.floor(a);t++){const n=i[t],s=e.measureText(n.name),r=s.actualBoundingBoxDescent-s.actualBoundingBoxAscent;l=null===l?s.width:Math.max(l,s.width),c=null===c?r:Math.max(c,r)}const u=l<s*t-2?1:(s*t-2)/l;for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=i[l],h=(l-o)*n*t+s*t/2,d=(r*t-c)/2;e.setTransform(u,0,0,1,h,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,n,this.positions,this.slider.min,this.slider.max);const s="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=o;e++)this.positions[e].render(a,s,l,c,this.palette)}finally{a.restore()}C._package.logger.debug(`${this.toLog()}.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.toLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=E.None,this.viewSyncer.sync(t,(async()=>{await this.renderInt(e)}))):C._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}getAlphabetSize(){return this.seqHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};C._package.logger.debug(`${this.toLog()}.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(E.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameFilterChanged()`);try{this.filterSource===m.Ct.Filtered&&this.render(E.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){C._package.logger.debug(`${this.toLog()}.dataFrameSelectionOnChanged()`);try{this.filterSource===m.Ct.Selected&&this.render(E.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const n=e,s=this.canvas.getCursorPosition(n,t),[o,a]=this.getMonomer(s,t),l=this.showPositionLabels?12*t:0;if(null!==o&&null===a&&0<=s.y&&s.y<=l){const e=[r.divText(`Position ${o.label}`)];this.valueAggrType===i.AGG.TOTAL_COUNT&&e.push(o.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,n.x+16,n.y+16)}else if(null!==o&&a&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=o.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==i.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const s=r.divV(t);r.tooltip.show(s,n.x+16,n.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,n=window.devicePixelRatio,[s,r]=this.getMonomer(this.canvas.getCursorPosition(t,n),n);if(null!==s&&null!==r&&this.dataFrame&&this.seqCol&&this.seqHandler){const e=i.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,n,s,r,i){const o=t.getSplitted(s),a=i.pos<o.length?o.getCanonical(i.pos):null;return null!==a&&a===r}(this.dataFrame,this.seqHandler,this.getFilter(),e,r,s)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const n=this.canvas.width/(this._positionWidthWithMargin*t),s=e.deltaY/100*Math.max(Math.floor(n/5),1);this.slider.scrollBy(this.slider.min+s)}catch(e){const t=p(e);C._package.logger.error(`${this.toLog()}.canvasOnWheel() error:\n`+t)}}get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,n=`${this.toLog()}.${t}`;this.render(E.None,t),this.viewSyncer.sync(`${n}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}_.residuesSet="nucleotides",_.viewerCounter=-1},8755:(e,t,n)=>{"use strict";n.d(t,{Y:()=>o,x:()=>i});var s=n(701),r=n(7422);class i{constructor(e,t=!0){return this.substructure=e,this.readOnly=t,new Proxy(this,{set:(e,t,n)=>{if(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${n}' )`),this.readOnly)throw new Error("Properties are immutable.");return e[t]=n,!0}})}}class o{constructor(){this.onChanged=new s.Subject,this._propsChanging=!1}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._props=e,this.applyProps(),this.onChanged.next()}finally{this._propsChanging=!1}}saveProps(){const e={};for(const[t,n]of Object.entries(this.props))"_onChanged"!==t&&(e[t]=this.props[t]);return e}async detach(){}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},5393:(e,t,n)=>{"use strict";n.d(t,{ST:()=>x});var s=n(3870),r=n(976),i=n(4469),o=n(6414),a=n.n(o),l=n(701),c=n(8447),u=n(2997),h=n(8607),d=n(172),m=n(7983),p=n(8755),f=n(3336),g=n.n(f),y=n(7945),b=n(4293),v=n(7422);class w extends p.Y{viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this._filterPanel=s.div("",{style:{cursor:"pointer"}}),this.viewerId=++w.viewerCounter,this.viewSubs=[],this.logger=v._package.logger}async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await async function(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}();let t,n;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await s.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=s.div(),n=e.createWebEditorApp(t,this.props.substructure),s.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.x(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,n=null}})).onCancel((()=>{g()(t).empty(),t=null,n=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(s.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(n){const e=n.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,n]=(0,y.yf)(e);this.logger.error(t,void 0,n)}})))}catch(e){const[t,n]=(0,y.yf)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),s.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,n=t/2;if(e)(0,b.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,n);else{const e=s.divText("Click to edit","helm-substructure-filter");(0,b.Y)(this._filterPanel,e)}}async substructureSearch(e){const t=`${this.viewerToLog()}.substructureSearch( column = <${e.name}> )`;v._package.logger.debug(`${t}, start`);try{return await(0,u.gw)(10),await(0,m.QF)(this.props.substructure,e)}finally{v._package.logger.debug(`${t}, end`)}}}w.viewerCounter=-1;const C="bio-substructure-filter";class A{constructor(e,t,n,s,r){this.props=e,this.filterId=t,this.dataFrameId=n,this.columnName=s,this.bitset=r}}class S extends p.x{constructor(e,t){super(e,!1),this.separator=t,this.readOnly=!0}}class x extends r.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.bioFilter=null,this.bitset=null,this.notation=void 0,this.filterId=++x.filterCounter,this.viewSubs=[],this._onRendered=new l.Subject,this.root=s.divV([]),this.loader=s.loader(),this.calculating=!1,this.filterSyncer=new d.c(this.logger=v._package.logger),new Proxy(this,{set:(e,t,n)=>(e[t]=n,!0)})}filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}attach(e){const t=super.attach.bind(this),n=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(n,(async()=>{t(e),this.column||(this.columnName?this.column=this.dataFrame.getCol(this.columnName):this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE)),h.g.forColumn(this.column),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(r.TAGS.UNITS)),this.bioFilter=this.notation===c.r2.FASTA?new E:this.notation===c.r2.SEPARATOR?new T(this.column.getTag(c.DX.separator)):new w,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(i.events.onResetFilterRequest.subscribe(this.grokEventsOnResetFilterRequest.bind(this))),this.viewSubs.push(i.events.onCustomEvent(C).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){const e=`${this.filterToLog()}.applyFilter()`;this.logger.debug(`${e}, IN`),this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=`${this.filterToLog()}.saveState()`,t=super.saveState();return this.logger.debug(`${e}, super.state = ${JSON.stringify(t)}`),t.props=this.bioFilter.saveProps(),t}applyState(e){const t=`${this.filterToLog()}.applyState()`;super.applyState(e),this.filterSyncer.sync(t,(async()=>{e.props&&this.bioFilter&&(this.bioFilter.props=r.toJs(e.props??{}))}))}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;v._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.saveProps())}`:"")),i.events.fireCustomEvent(C,new A(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(v._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.saveProps())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{v._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),v._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,v._package.logger.debug(`${e}, end`)}}))}grokEventsOnResetFilterRequest(){const e=`${this.filterToLog()}.grokEventsOnResetFilterRequest()`;v._package.logger.debug(`${e}`),this.bioFilter?.resetFilter()}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} )`,n=`${this.filterToLog()}.${t}`;await(0,u.gw)(10),await(0,u.zg)(this.onRendered,(()=>{this.logger.debug(`${n}, _onRendered event caught`)}),(()=>{this.invalidate(t)}),e,`${n} timeout`);const s=this.filterSyncer.resetErrors();if(s.length>0)throw s[0]}}x.filterCounter=-1;class E extends p.Y{get type(){return"FastaBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this.substructureInput=s.stringInput("","",(()=>{this.props=new p.x(this.substructureInput.value),this._propsChanging||this.onChanged.next()}),{placeholder:"Substructure"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure)}get filterPanel(){return this.substructureInput.root}get isFiltering(){return""!==this.substructureInput.value}async substructureSearch(e){return(0,m.pf)(this.props.substructure,e)}async attach(){}async detach(){await super.detach()}}class T extends p.Y{get type(){return"SeparatorBioFilter"}constructor(e){super(),this.emptyProps=new S("",void 0),this.colSeparator="",this.substructureInput=s.stringInput("","",(()=>{this.props=new S(this.substructureInput.value,this.props.separator),this._propsChanging||this.onChanged.next()}),{placeholder:"Substructure"}),this.separatorInput=s.stringInput("",this.colSeparator=e,(()=>{const e=this.separatorInput.value?this.separatorInput.value:void 0;this.props=new S(this.props.substructure,e),this._propsChanging||this.onChanged.next()}),{placeholder:"Separator"})}applyProps(){this.substructureInput.value!==this.props.substructure&&(this.substructureInput.value=this.props.substructure);const e=this.props.separator??this.colSeparator;this.separatorInput.value!==e&&(this.separatorInput.value=e)}get filterSummary(){return this.props.separator?this.props.separator:this.colSeparator,`${this.props.substructure}, {sep}`}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=new S("")}get filterPanel(){return s.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(e){this.substructureInput.value=e}async substructureSearch(e){return(0,m.pf)(this.substructure,e,this.colSeparator)}async attach(){}async detach(){await super.detach()}}},8770:(e,t,n)=>{"use strict";n.d(t,{_:()=>T,t:()=>E});var s=n(3870),r=n(976),i=n(6414),o=n.n(i),a=n(8447),l=n(7331),c=n(3379),u=n.n(c),h=n(7795),d=n.n(h),m=n(569),p=n.n(m),f=n(3565),g=n.n(f),y=n(9216),b=n.n(y),v=n(4589),w=n.n(v),C=n(5362),A={};A.styleTagTransform=w(),A.setAttributes=g(),A.insert=p().bind(null,"head"),A.domAPI=d(),A.insertStyleElement=b(),u()(C.Z,A),C.Z&&C.Z.locals&&C.Z.locals;var S=n(8607),x=n(6286);function E(e){const t=s.div();t.classList.add("macromolecule-cell-comp-analysis-host");const n=e.cell.column.tags[a.DX.alphabet];let i=l.UE.Color;switch(n){case a.fb.DNA:case a.fb.RNA:i=(0,a.py)(a.fb.DNA);break;case a.fb.PT:i=(0,a.py)(a.fb.PT)}const c={},u=S.g.forColumn(e.cell.column),h=e.cell.rowIndex,d=u.getSplitted(h);o()(d.canonicals).filter((e=>e!==x.G2)).forEach((e=>{const t=c[e]||0;c[e]=t+1}));const m=T(i,c);return Array.from(m.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),t.appendChild(m),new r.Widget(t)}function T(e,t){let n=0,i=null;for(const e of Object.values(t))n+=e,i=null===i?e:Math.max(i,e);const o=i/n,a=Object.assign({},...Array.from(Object.entries(t)).sort(((e,t)=>t[1]-e[1])).map((([t,i])=>{const a=i/n,l=e.get(t),c=s.div("",{classes:"macromolecule-cell-comp-analysis-bar"});c.style.width=50*a/o+"px",c.style.backgroundColor=l,x.G2===t&&(c.style.borderWidth="1px",c.style.borderStyle="solid",c.style.borderColor=r.Color.toHtml(r.Color.lightGray));const u=x.G2===t?"-":t,h=s.div(`${(100*a).toFixed(2)}%`);return{[u]:s.div([c,h],{classes:"macromolecule-cell-comp-analysis-value"})}}))),l=s.tableFromMap(a);return Array.from(l.rows).forEach((e=>{const t=e.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;e.cells[0].style.color=t})),l}},540:function(e,t){!function(e){"use strict";function t(){for(var e=arguments.length,t=Array(e),n=0;n<e;n++)t[n]=arguments[n];if(t.length>1){t[0]=t[0].slice(0,-1);for(var s=t.length-1,r=1;r<s;++r)t[r]=t[r].slice(1,-1);return t[s]=t[s].slice(1),t.join("")}return t[0]}function n(e){return"(?:"+e+")"}function s(e){return void 0===e?"undefined":null===e?"null":Object.prototype.toString.call(e).split(" ").pop().split("]").shift().toLowerCase()}function r(e){return e.toUpperCase()}function i(e){var s="[A-Za-z]",r="[0-9]",i=t(r,"[A-Fa-f]"),o=n(n("%[EFef]"+i+"%"+i+i+"%"+i+i)+"|"+n("%[89A-Fa-f]"+i+"%"+i+i)+"|"+n("%"+i+i)),a="[\\!\\$\\&\\'\\(\\)\\*\\+\\,\\;\\=]",l=t("[\\:\\/\\?\\#\\[\\]\\@]",a),c=e?"[\\uE000-\\uF8FF]":"[]",u=t(s,r,"[\\-\\.\\_\\~]",e?"[\\xA0-\\u200D\\u2010-\\u2029\\u202F-\\uD7FF\\uF900-\\uFDCF\\uFDF0-\\uFFEF]":"[]"),h=n(s+t(s,r,"[\\+\\-\\.]")+"*"),d=n(n(o+"|"+t(u,a,"[\\:]"))+"*"),m=(n(n("25[0-5]")+"|"+n("2[0-4]"+r)+"|"+n("1"+r+r)+"|"+n("[1-9]"+r)+"|"+r),n(n("25[0-5]")+"|"+n("2[0-4]"+r)+"|"+n("1"+r+r)+"|"+n("0?[1-9]"+r)+"|0?0?"+r)),p=n(m+"\\."+m+"\\."+m+"\\."+m),f=n(i+"{1,4}"),g=n(n(f+"\\:"+f)+"|"+p),y=n(n(f+"\\:")+"{6}"+g),b=n("\\:\\:"+n(f+"\\:")+"{5}"+g),v=n(n(f)+"?\\:\\:"+n(f+"\\:")+"{4}"+g),w=n(n(n(f+"\\:")+"{0,1}"+f)+"?\\:\\:"+n(f+"\\:")+"{3}"+g),C=n(n(n(f+"\\:")+"{0,2}"+f)+"?\\:\\:"+n(f+"\\:")+"{2}"+g),A=n(n(n(f+"\\:")+"{0,3}"+f)+"?\\:\\:"+f+"\\:"+g),S=n(n(n(f+"\\:")+"{0,4}"+f)+"?\\:\\:"+g),x=n(n(n(f+"\\:")+"{0,5}"+f)+"?\\:\\:"+f),E=n(n(n(f+"\\:")+"{0,6}"+f)+"?\\:\\:"),T=n([y,b,v,w,C,A,S,x,E].join("|")),_=n(n(u+"|"+o)+"+"),I=(n(T+"\\%25"+_),n(T+n("\\%25|\\%(?!"+i+"{2})")+_)),M=n("[vV]"+i+"+\\."+t(u,a,"[\\:]")+"+"),N=n("\\["+n(I+"|"+T+"|"+M)+"\\]"),$=n(n(o+"|"+t(u,a))+"*"),L=n(N+"|"+p+"(?!"+$+")|"+$),P=n(r+"*"),R=n(n(d+"@")+"?"+L+n("\\:"+P)+"?"),O=n(o+"|"+t(u,a,"[\\:\\@]")),k=n(O+"*"),D=n(O+"+"),F=n(n(o+"|"+t(u,a,"[\\@]"))+"+"),G=n(n("\\/"+k)+"*"),B=n("\\/"+n(D+G)+"?"),V=n(F+G),U=n(D+G),H="(?!"+O+")",j=(n(G+"|"+B+"|"+V+"|"+U+"|"+H),n(n(O+"|"+t("[\\/\\?]",c))+"*")),W=n(n(O+"|[\\/\\?]")+"*"),Y=n(n("\\/\\/"+R+G)+"|"+B+"|"+U+"|"+H),Z=n(h+"\\:"+Y+n("\\?"+j)+"?"+n("\\#"+W)+"?"),q=n(n("\\/\\/"+R+G)+"|"+B+"|"+V+"|"+H),K=n(q+n("\\?"+j)+"?"+n("\\#"+W)+"?");return n(Z+"|"+K),n(h+"\\:"+Y+n("\\?"+j)+"?"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+U+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+V+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n(n("\\/\\/("+n("("+d+")@")+"?("+L+")"+n("\\:("+P+")")+"?)")+"?("+G+"|"+B+"|"+U+"|"+H+")"),n("\\?("+j+")"),n("\\#("+W+")"),n("("+d+")@"),n("\\:("+P+")"),{NOT_SCHEME:new RegExp(t("[^]",s,r,"[\\+\\-\\.]"),"g"),NOT_USERINFO:new RegExp(t("[^\\%\\:]",u,a),"g"),NOT_HOST:new RegExp(t("[^\\%\\[\\]\\:]",u,a),"g"),NOT_PATH:new RegExp(t("[^\\%\\/\\:\\@]",u,a),"g"),NOT_PATH_NOSCHEME:new RegExp(t("[^\\%\\/\\@]",u,a),"g"),NOT_QUERY:new RegExp(t("[^\\%]",u,a,"[\\:\\@\\/\\?]",c),"g"),NOT_FRAGMENT:new RegExp(t("[^\\%]",u,a,"[\\:\\@\\/\\?]"),"g"),ESCAPE:new RegExp(t("[^]",u,a),"g"),UNRESERVED:new RegExp(u,"g"),OTHER_CHARS:new RegExp(t("[^\\%]",u,l),"g"),PCT_ENCODED:new RegExp(o,"g"),IPV4ADDRESS:new RegExp("^("+p+")$"),IPV6ADDRESS:new RegExp("^\\[?("+T+")"+n(n("\\%25|\\%(?!"+i+"{2})")+"("+_+")")+"?\\]?$")}}var o=i(!1),a=i(!0),l=function(e,t){if(Array.isArray(e))return e;if(Symbol.iterator in Object(e))return function(e,t){var n=[],s=!0,r=!1,i=void 0;try{for(var o,a=e[Symbol.iterator]();!(s=(o=a.next()).done)&&(n.push(o.value),!t||n.length!==t);s=!0);}catch(e){r=!0,i=e}finally{try{!s&&a.return&&a.return()}finally{if(r)throw i}}return n}(e,t);throw new TypeError("Invalid attempt to destructure non-iterable instance")},c=2147483647,u=36,h=/^xn--/,d=/[^\0-\x7E]/,m=/[\x2E\u3002\uFF0E\uFF61]/g,p={overflow:"Overflow: input needs wider integers to process","not-basic":"Illegal input >= 0x80 (not a basic code point)","invalid-input":"Invalid input"},f=Math.floor,g=String.fromCharCode;function y(e){throw new RangeError(p[e])}function b(e,t){var n=e.split("@"),s="";return n.length>1&&(s=n[0]+"@",e=n[1]),s+function(e,t){for(var n=[],s=e.length;s--;)n[s]=t(e[s]);return n}((e=e.replace(m,".")).split("."),t).join(".")}function v(e){for(var t=[],n=0,s=e.length;n<s;){var r=e.charCodeAt(n++);if(r>=55296&&r<=56319&&n<s){var i=e.charCodeAt(n++);56320==(64512&i)?t.push(((1023&r)<<10)+(1023&i)+65536):(t.push(r),n--)}else t.push(r)}return t}var w=function(e,t){return e+22+75*(e<26)-((0!=t)<<5)},C=function(e,t,n){var s=0;for(e=n?f(e/700):e>>1,e+=f(e/t);e>455;s+=u)e=f(e/35);return f(s+36*e/(e+38))},A=function(e){var t,n=[],s=e.length,r=0,i=128,o=72,a=e.lastIndexOf("-");a<0&&(a=0);for(var l=0;l<a;++l)e.charCodeAt(l)>=128&&y("not-basic"),n.push(e.charCodeAt(l));for(var h=a>0?a+1:0;h<s;){for(var d=r,m=1,p=u;;p+=u){h>=s&&y("invalid-input");var g=(t=e.charCodeAt(h++))-48<10?t-22:t-65<26?t-65:t-97<26?t-97:u;(g>=u||g>f((c-r)/m))&&y("overflow"),r+=g*m;var b=p<=o?1:p>=o+26?26:p-o;if(g<b)break;var v=u-b;m>f(c/v)&&y("overflow"),m*=v}var w=n.length+1;o=C(r-d,w,0==d),f(r/w)>c-i&&y("overflow"),i+=f(r/w),r%=w,n.splice(r++,0,i)}return String.fromCodePoint.apply(String,n)},S=function(e){var t=[],n=(e=v(e)).length,s=128,r=0,i=72,o=!0,a=!1,l=void 0;try{for(var h,d=e[Symbol.iterator]();!(o=(h=d.next()).done);o=!0){var m=h.value;m<128&&t.push(g(m))}}catch(e){a=!0,l=e}finally{try{!o&&d.return&&d.return()}finally{if(a)throw l}}var p=t.length,b=p;for(p&&t.push("-");b<n;){var A=c,S=!0,x=!1,E=void 0;try{for(var T,_=e[Symbol.iterator]();!(S=(T=_.next()).done);S=!0){var I=T.value;I>=s&&I<A&&(A=I)}}catch(e){x=!0,E=e}finally{try{!S&&_.return&&_.return()}finally{if(x)throw E}}var M=b+1;A-s>f((c-r)/M)&&y("overflow"),r+=(A-s)*M,s=A;var N=!0,$=!1,L=void 0;try{for(var P,R=e[Symbol.iterator]();!(N=(P=R.next()).done);N=!0){var O=P.value;if(O<s&&++r>c&&y("overflow"),O==s){for(var k=r,D=u;;D+=u){var F=D<=i?1:D>=i+26?26:D-i;if(k<F)break;var G=k-F,B=u-F;t.push(g(w(F+G%B,0))),k=f(G/B)}t.push(g(w(k,0))),i=C(r,M,b==p),r=0,++b}}}catch(e){$=!0,L=e}finally{try{!N&&R.return&&R.return()}finally{if($)throw L}}++r,++s}return t.join("")},x={version:"2.1.0",ucs2:{decode:v,encode:function(e){return String.fromCodePoint.apply(String,function(e){if(Array.isArray(e)){for(var t=0,n=Array(e.length);t<e.length;t++)n[t]=e[t];return n}return Array.from(e)}(e))}},decode:A,encode:S,toASCII:function(e){return b(e,(function(e){return d.test(e)?"xn--"+S(e):e}))},toUnicode:function(e){return b(e,(function(e){return h.test(e)?A(e.slice(4).toLowerCase()):e}))}},E={};function T(e){var t=e.charCodeAt(0);return t<16?"%0"+t.toString(16).toUpperCase():t<128?"%"+t.toString(16).toUpperCase():t<2048?"%"+(t>>6|192).toString(16).toUpperCase()+"%"+(63&t|128).toString(16).toUpperCase():"%"+(t>>12|224).toString(16).toUpperCase()+"%"+(t>>6&63|128).toString(16).toUpperCase()+"%"+(63&t|128).toString(16).toUpperCase()}function _(e){for(var t="",n=0,s=e.length;n<s;){var r=parseInt(e.substr(n+1,2),16);if(r<128)t+=String.fromCharCode(r),n+=3;else if(r>=194&&r<224){if(s-n>=6){var i=parseInt(e.substr(n+4,2),16);t+=String.fromCharCode((31&r)<<6|63&i)}else t+=e.substr(n,6);n+=6}else if(r>=224){if(s-n>=9){var o=parseInt(e.substr(n+4,2),16),a=parseInt(e.substr(n+7,2),16);t+=String.fromCharCode((15&r)<<12|(63&o)<<6|63&a)}else t+=e.substr(n,9);n+=9}else t+=e.substr(n,3),n+=3}return t}function I(e,t){function n(e){var n=_(e);return n.match(t.UNRESERVED)?n:e}return e.scheme&&(e.scheme=String(e.scheme).replace(t.PCT_ENCODED,n).toLowerCase().replace(t.NOT_SCHEME,"")),void 0!==e.userinfo&&(e.userinfo=String(e.userinfo).replace(t.PCT_ENCODED,n).replace(t.NOT_USERINFO,T).replace(t.PCT_ENCODED,r)),void 0!==e.host&&(e.host=String(e.host).replace(t.PCT_ENCODED,n).toLowerCase().replace(t.NOT_HOST,T).replace(t.PCT_ENCODED,r)),void 0!==e.path&&(e.path=String(e.path).replace(t.PCT_ENCODED,n).replace(e.scheme?t.NOT_PATH:t.NOT_PATH_NOSCHEME,T).replace(t.PCT_ENCODED,r)),void 0!==e.query&&(e.query=String(e.query).replace(t.PCT_ENCODED,n).replace(t.NOT_QUERY,T).replace(t.PCT_ENCODED,r)),void 0!==e.fragment&&(e.fragment=String(e.fragment).replace(t.PCT_ENCODED,n).replace(t.NOT_FRAGMENT,T).replace(t.PCT_ENCODED,r)),e}function M(e){return e.replace(/^0*(.*)/,"$1")||"0"}function N(e,t){var n=e.match(t.IPV4ADDRESS)||[],s=l(n,2)[1];return s?s.split(".").map(M).join("."):e}function $(e,t){var n=e.match(t.IPV6ADDRESS)||[],s=l(n,3),r=s[1],i=s[2];if(r){for(var o=r.toLowerCase().split("::").reverse(),a=l(o,2),c=a[0],u=a[1],h=u?u.split(":").map(M):[],d=c.split(":").map(M),m=t.IPV4ADDRESS.test(d[d.length-1]),p=m?7:8,f=d.length-p,g=Array(p),y=0;y<p;++y)g[y]=h[y]||d[f+y]||"";m&&(g[p-1]=N(g[p-1],t));var b=g.reduce((function(e,t,n){if(!t||"0"===t){var s=e[e.length-1];s&&s.index+s.length===n?s.length++:e.push({index:n,length:1})}return e}),[]).sort((function(e,t){return t.length-e.length}))[0],v=void 0;if(b&&b.length>1){var w=g.slice(0,b.index),C=g.slice(b.index+b.length);v=w.join(":")+"::"+C.join(":")}else v=g.join(":");return i&&(v+="%"+i),v}return e}var L=/^(?:([^:\/?#]+):)?(?:\/\/((?:([^\/?#@]*)@)?(\[[^\/?#\]]+\]|[^\/?#:]*)(?:\:(\d*))?))?([^?#]*)(?:\?([^#]*))?(?:#((?:.|\n|\r)*))?/i,P=void 0==="".match(/(){0}/)[1];function R(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n={},s=!1!==t.iri?a:o;"suffix"===t.reference&&(e=(t.scheme?t.scheme+":":"")+"//"+e);var r=e.match(L);if(r){P?(n.scheme=r[1],n.userinfo=r[3],n.host=r[4],n.port=parseInt(r[5],10),n.path=r[6]||"",n.query=r[7],n.fragment=r[8],isNaN(n.port)&&(n.port=r[5])):(n.scheme=r[1]||void 0,n.userinfo=-1!==e.indexOf("@")?r[3]:void 0,n.host=-1!==e.indexOf("//")?r[4]:void 0,n.port=parseInt(r[5],10),n.path=r[6]||"",n.query=-1!==e.indexOf("?")?r[7]:void 0,n.fragment=-1!==e.indexOf("#")?r[8]:void 0,isNaN(n.port)&&(n.port=e.match(/\/\/(?:.|\n)*\:(?:\/|\?|\#|$)/)?r[4]:void 0)),n.host&&(n.host=$(N(n.host,s),s)),void 0!==n.scheme||void 0!==n.userinfo||void 0!==n.host||void 0!==n.port||n.path||void 0!==n.query?void 0===n.scheme?n.reference="relative":void 0===n.fragment?n.reference="absolute":n.reference="uri":n.reference="same-document",t.reference&&"suffix"!==t.reference&&t.reference!==n.reference&&(n.error=n.error||"URI is not a "+t.reference+" reference.");var i=E[(t.scheme||n.scheme||"").toLowerCase()];if(t.unicodeSupport||i&&i.unicodeSupport)I(n,s);else{if(n.host&&(t.domainHost||i&&i.domainHost))try{n.host=x.toASCII(n.host.replace(s.PCT_ENCODED,_).toLowerCase())}catch(e){n.error=n.error||"Host's domain name can not be converted to ASCII via punycode: "+e}I(n,o)}i&&i.parse&&i.parse(n,t)}else n.error=n.error||"URI can not be parsed.";return n}var O=/^\.\.?\//,k=/^\/\.(\/|$)/,D=/^\/\.\.(\/|$)/,F=/^\/?(?:.|\n)*?(?=\/|$)/;function G(e){for(var t=[];e.length;)if(e.match(O))e=e.replace(O,"");else if(e.match(k))e=e.replace(k,"/");else if(e.match(D))e=e.replace(D,"/"),t.pop();else if("."===e||".."===e)e="";else{var n=e.match(F);if(!n)throw new Error("Unexpected dot segment condition");var s=n[0];e=e.slice(s.length),t.push(s)}return t.join("")}function B(e){var t=arguments.length>1&&void 0!==arguments[1]?arguments[1]:{},n=t.iri?a:o,s=[],r=E[(t.scheme||e.scheme||"").toLowerCase()];if(r&&r.serialize&&r.serialize(e,t),e.host)if(n.IPV6ADDRESS.test(e.host));else if(t.domainHost||r&&r.domainHost)try{e.host=t.iri?x.toUnicode(e.host):x.toASCII(e.host.replace(n.PCT_ENCODED,_).toLowerCase())}catch(n){e.error=e.error||"Host's domain name can not be converted to "+(t.iri?"Unicode":"ASCII")+" via punycode: "+n}I(e,n),"suffix"!==t.reference&&e.scheme&&(s.push(e.scheme),s.push(":"));var i=function(e,t){var n=!1!==t.iri?a:o,s=[];return void 0!==e.userinfo&&(s.push(e.userinfo),s.push("@")),void 0!==e.host&&s.push($(N(String(e.host),n),n).replace(n.IPV6ADDRESS,(function(e,t,n){return"["+t+(n?"%25"+n:"")+"]"}))),"number"!=typeof e.port&&"string"!=typeof e.port||(s.push(":"),s.push(String(e.port))),s.length?s.join(""):void 0}(e,t);if(void 0!==i&&("suffix"!==t.reference&&s.push("//"),s.push(i),e.path&&"/"!==e.path.charAt(0)&&s.push("/")),void 0!==e.path){var l=e.path;t.absolutePath||r&&r.absolutePath||(l=G(l)),void 0===i&&(l=l.replace(/^\/\//,"/%2F")),s.push(l)}return void 0!==e.query&&(s.push("?"),s.push(e.query)),void 0!==e.fragment&&(s.push("#"),s.push(e.fragment)),s.join("")}function V(e,t){var n=arguments.length>2&&void 0!==arguments[2]?arguments[2]:{},s={};return arguments[3]||(e=R(B(e,n),n),t=R(B(t,n),n)),!(n=n||{}).tolerant&&t.scheme?(s.scheme=t.scheme,s.userinfo=t.userinfo,s.host=t.host,s.port=t.port,s.path=G(t.path||""),s.query=t.query):(void 0!==t.userinfo||void 0!==t.host||void 0!==t.port?(s.userinfo=t.userinfo,s.host=t.host,s.port=t.port,s.path=G(t.path||""),s.query=t.query):(t.path?("/"===t.path.charAt(0)?s.path=G(t.path):(void 0===e.userinfo&&void 0===e.host&&void 0===e.port||e.path?e.path?s.path=e.path.slice(0,e.path.lastIndexOf("/")+1)+t.path:s.path=t.path:s.path="/"+t.path,s.path=G(s.path)),s.query=t.query):(s.path=e.path,void 0!==t.query?s.query=t.query:s.query=e.query),s.userinfo=e.userinfo,s.host=e.host,s.port=e.port),s.scheme=e.scheme),s.fragment=t.fragment,s}function U(e,t){return e&&e.toString().replace(t&&t.iri?a.PCT_ENCODED:o.PCT_ENCODED,_)}var H={scheme:"http",domainHost:!0,parse:function(e,t){return e.host||(e.error=e.error||"HTTP URIs must have a host."),e},serialize:function(e,t){var n="https"===String(e.scheme).toLowerCase();return e.port!==(n?443:80)&&""!==e.port||(e.port=void 0),e.path||(e.path="/"),e}},j={scheme:"https",domainHost:H.domainHost,parse:H.parse,serialize:H.serialize};function W(e){return"boolean"==typeof e.secure?e.secure:"wss"===String(e.scheme).toLowerCase()}var Y={scheme:"ws",domainHost:!0,parse:function(e,t){var n=e;return n.secure=W(n),n.resourceName=(n.path||"/")+(n.query?"?"+n.query:""),n.path=void 0,n.query=void 0,n},serialize:function(e,t){if(e.port!==(W(e)?443:80)&&""!==e.port||(e.port=void 0),"boolean"==typeof e.secure&&(e.scheme=e.secure?"wss":"ws",e.secure=void 0),e.resourceName){var n=e.resourceName.split("?"),s=l(n,2),r=s[0],i=s[1];e.path=r&&"/"!==r?r:void 0,e.query=i,e.resourceName=void 0}return e.fragment=void 0,e}},Z={scheme:"wss",domainHost:Y.domainHost,parse:Y.parse,serialize:Y.serialize},q={},K="[A-Za-z0-9\\-\\.\\_\\~\\xA0-\\u200D\\u2010-\\u2029\\u202F-\\uD7FF\\uF900-\\uFDCF\\uFDF0-\\uFFEF]",z="[0-9A-Fa-f]",X=n(n("%[EFef]"+z+"%"+z+z+"%"+z+z)+"|"+n("%[89A-Fa-f]"+z+"%"+z+z)+"|"+n("%"+z+z)),J=t("[\\!\\$\\%\\'\\(\\)\\*\\+\\,\\-\\.0-9\\<\\>A-Z\\x5E-\\x7E]",'[\\"\\\\]'),Q=new RegExp(K,"g"),ee=new RegExp(X,"g"),te=new RegExp(t("[^]","[A-Za-z0-9\\!\\$\\%\\'\\*\\+\\-\\^\\_\\`\\{\\|\\}\\~]","[\\.]",'[\\"]',J),"g"),ne=new RegExp(t("[^]",K,"[\\!\\$\\'\\(\\)\\*\\+\\,\\;\\:\\@]"),"g"),se=ne;function re(e){var t=_(e);return t.match(Q)?t:e}var ie={scheme:"mailto",parse:function(e,t){var n=e,s=n.to=n.path?n.path.split(","):[];if(n.path=void 0,n.query){for(var r=!1,i={},o=n.query.split("&"),a=0,l=o.length;a<l;++a){var c=o[a].split("=");switch(c[0]){case"to":for(var u=c[1].split(","),h=0,d=u.length;h<d;++h)s.push(u[h]);break;case"subject":n.subject=U(c[1],t);break;case"body":n.body=U(c[1],t);break;default:r=!0,i[U(c[0],t)]=U(c[1],t)}}r&&(n.headers=i)}n.query=void 0;for(var m=0,p=s.length;m<p;++m){var f=s[m].split("@");if(f[0]=U(f[0]),t.unicodeSupport)f[1]=U(f[1],t).toLowerCase();else try{f[1]=x.toASCII(U(f[1],t).toLowerCase())}catch(e){n.error=n.error||"Email address's domain name can not be converted to ASCII via punycode: "+e}s[m]=f.join("@")}return n},serialize:function(e,t){var n,s=e,i=null!=(n=e.to)?n instanceof Array?n:"number"!=typeof n.length||n.split||n.setInterval||n.call?[n]:Array.prototype.slice.call(n):[];if(i){for(var o=0,a=i.length;o<a;++o){var l=String(i[o]),c=l.lastIndexOf("@"),u=l.slice(0,c).replace(ee,re).replace(ee,r).replace(te,T),h=l.slice(c+1);try{h=t.iri?x.toUnicode(h):x.toASCII(U(h,t).toLowerCase())}catch(e){s.error=s.error||"Email address's domain name can not be converted to "+(t.iri?"Unicode":"ASCII")+" via punycode: "+e}i[o]=u+"@"+h}s.path=i.join(",")}var d=e.headers=e.headers||{};e.subject&&(d.subject=e.subject),e.body&&(d.body=e.body);var m=[];for(var p in d)d[p]!==q[p]&&m.push(p.replace(ee,re).replace(ee,r).replace(ne,T)+"="+d[p].replace(ee,re).replace(ee,r).replace(se,T));return m.length&&(s.query=m.join("&")),s}},oe=/^([^\:]+)\:(.*)/,ae={scheme:"urn",parse:function(e,t){var n=e.path&&e.path.match(oe),s=e;if(n){var r=t.scheme||s.scheme||"urn",i=n[1].toLowerCase(),o=n[2],a=r+":"+(t.nid||i),l=E[a];s.nid=i,s.nss=o,s.path=void 0,l&&(s=l.parse(s,t))}else s.error=s.error||"URN can not be parsed.";return s},serialize:function(e,t){var n=t.scheme||e.scheme||"urn",s=e.nid,r=n+":"+(t.nid||s),i=E[r];i&&(e=i.serialize(e,t));var o=e,a=e.nss;return o.path=(s||t.nid)+":"+a,o}},le=/^[0-9A-Fa-f]{8}(?:\-[0-9A-Fa-f]{4}){3}\-[0-9A-Fa-f]{12}$/,ce={scheme:"urn:uuid",parse:function(e,t){var n=e;return n.uuid=n.nss,n.nss=void 0,t.tolerant||n.uuid&&n.uuid.match(le)||(n.error=n.error||"UUID is not valid."),n},serialize:function(e,t){var n=e;return n.nss=(e.uuid||"").toLowerCase(),n}};E[H.scheme]=H,E[j.scheme]=j,E[Y.scheme]=Y,E[Z.scheme]=Z,E[ie.scheme]=ie,E[ae.scheme]=ae,E[ce.scheme]=ce,e.SCHEMES=E,e.pctEncChar=T,e.pctDecChars=_,e.parse=R,e.removeDotSegments=G,e.serialize=B,e.resolveComponents=V,e.resolve=function(e,t,n){var s=function(e,t){var n=e;if(t)for(var s in t)n[s]=t[s];return n}({scheme:"null"},n);return B(V(R(e,s),R(t,s),s,!0),s)},e.normalize=function(e,t){return"string"==typeof e?e=B(R(e,t),t):"object"===s(e)&&(e=R(B(e,t),t)),e},e.equal=function(e,t,n){return"string"==typeof e?e=B(R(e,n),n):"object"===s(e)&&(e=B(e,n)),"string"==typeof t?t=B(R(t,n),n):"object"===s(t)&&(t=B(t,n)),e===t},e.escapeComponent=function(e,t){return e&&e.toString().replace(t&&t.iri?a.ESCAPE:o.ESCAPE,T)},e.unescapeComponent=U,Object.defineProperty(e,"__esModule",{value:!0})}(t)},3336:e=>{"use strict";e.exports=$},976:e=>{"use strict";e.exports=DG},4469:e=>{"use strict";e.exports=grok},701:e=>{"use strict";e.exports=rxjs},3870:e=>{"use strict";e.exports=ui},6414:e=>{"use strict";e.exports=wu},4775:e=>{"use strict";e.exports=JSON.parse('{"$id":"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#","description":"Meta-schema for $data reference (JSON AnySchema extension proposal)","type":"object","required":["$data"],"properties":{"$data":{"type":"string","anyOf":[{"format":"relative-json-pointer"},{"format":"json-pointer"}]}},"additionalProperties":false}')},996:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/applicator","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/applicator":true},"$dynamicAnchor":"meta","title":"Applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"prefixItems":{"$ref":"#/$defs/schemaArray"},"items":{"$dynamicRef":"#meta"},"contains":{"$dynamicRef":"#meta"},"additionalProperties":{"$dynamicRef":"#meta"},"properties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"propertyNames":{"format":"regex"},"default":{}},"dependentSchemas":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"},"default":{}},"propertyNames":{"$dynamicRef":"#meta"},"if":{"$dynamicRef":"#meta"},"then":{"$dynamicRef":"#meta"},"else":{"$dynamicRef":"#meta"},"allOf":{"$ref":"#/$defs/schemaArray"},"anyOf":{"$ref":"#/$defs/schemaArray"},"oneOf":{"$ref":"#/$defs/schemaArray"},"not":{"$dynamicRef":"#meta"}},"$defs":{"schemaArray":{"type":"array","minItems":1,"items":{"$dynamicRef":"#meta"}}}}')},6795:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/content","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Content vocabulary meta-schema","type":["object","boolean"],"properties":{"contentEncoding":{"type":"string"},"contentMediaType":{"type":"string"},"contentSchema":{"$dynamicRef":"#meta"}}}')},235:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/core","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true},"$dynamicAnchor":"meta","title":"Core vocabulary meta-schema","type":["object","boolean"],"properties":{"$id":{"$ref":"#/$defs/uriReferenceString","$comment":"Non-empty fragments not allowed.","pattern":"^[^#]*#?$"},"$schema":{"$ref":"#/$defs/uriString"},"$ref":{"$ref":"#/$defs/uriReferenceString"},"$anchor":{"$ref":"#/$defs/anchorString"},"$dynamicRef":{"$ref":"#/$defs/uriReferenceString"},"$dynamicAnchor":{"$ref":"#/$defs/anchorString"},"$vocabulary":{"type":"object","propertyNames":{"$ref":"#/$defs/uriString"},"additionalProperties":{"type":"boolean"}},"$comment":{"type":"string"},"$defs":{"type":"object","additionalProperties":{"$dynamicRef":"#meta"}}},"$defs":{"anchorString":{"type":"string","pattern":"^[A-Za-z_][-A-Za-z0-9._]*$"},"uriString":{"type":"string","format":"uri"},"uriReferenceString":{"type":"string","format":"uri-reference"}}}')},2567:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/format-annotation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/format-annotation":true},"$dynamicAnchor":"meta","title":"Format vocabulary meta-schema for annotation results","type":["object","boolean"],"properties":{"format":{"type":"string"}}}')},1233:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/meta-data","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/meta-data":true},"$dynamicAnchor":"meta","title":"Meta-data vocabulary meta-schema","type":["object","boolean"],"properties":{"title":{"type":"string"},"description":{"type":"string"},"default":true,"deprecated":{"type":"boolean","default":false},"readOnly":{"type":"boolean","default":false},"writeOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true}}}')},5568:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/unevaluated","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/unevaluated":true},"$dynamicAnchor":"meta","title":"Unevaluated applicator vocabulary meta-schema","type":["object","boolean"],"properties":{"unevaluatedItems":{"$dynamicRef":"#meta"},"unevaluatedProperties":{"$dynamicRef":"#meta"}}}')},1968:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/meta/validation","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/validation":true},"$dynamicAnchor":"meta","title":"Validation vocabulary meta-schema","type":["object","boolean"],"properties":{"type":{"anyOf":[{"$ref":"#/$defs/simpleTypes"},{"type":"array","items":{"$ref":"#/$defs/simpleTypes"},"minItems":1,"uniqueItems":true}]},"const":true,"enum":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/$defs/nonNegativeInteger"},"minLength":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"maxItems":{"$ref":"#/$defs/nonNegativeInteger"},"minItems":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"maxContains":{"$ref":"#/$defs/nonNegativeInteger"},"minContains":{"$ref":"#/$defs/nonNegativeInteger","default":1},"maxProperties":{"$ref":"#/$defs/nonNegativeInteger"},"minProperties":{"$ref":"#/$defs/nonNegativeIntegerDefault0"},"required":{"$ref":"#/$defs/stringArray"},"dependentRequired":{"type":"object","additionalProperties":{"$ref":"#/$defs/stringArray"}}},"$defs":{"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"$ref":"#/$defs/nonNegativeInteger","default":0},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}}}')},2577:e=>{"use strict";e.exports=JSON.parse('{"$schema":"https://json-schema.org/draft/2020-12/schema","$id":"https://json-schema.org/draft/2020-12/schema","$vocabulary":{"https://json-schema.org/draft/2020-12/vocab/core":true,"https://json-schema.org/draft/2020-12/vocab/applicator":true,"https://json-schema.org/draft/2020-12/vocab/unevaluated":true,"https://json-schema.org/draft/2020-12/vocab/validation":true,"https://json-schema.org/draft/2020-12/vocab/meta-data":true,"https://json-schema.org/draft/2020-12/vocab/format-annotation":true,"https://json-schema.org/draft/2020-12/vocab/content":true},"$dynamicAnchor":"meta","title":"Core and Validation specifications meta-schema","allOf":[{"$ref":"meta/core"},{"$ref":"meta/applicator"},{"$ref":"meta/unevaluated"},{"$ref":"meta/validation"},{"$ref":"meta/meta-data"},{"$ref":"meta/format-annotation"},{"$ref":"meta/content"}],"type":["object","boolean"],"$comment":"This meta-schema also defines keywords that have appeared in previous drafts in order to prevent incompatible extensions as they remain in common use.","properties":{"definitions":{"$comment":"\\"definitions\\" has been replaced by \\"$defs\\".","type":"object","additionalProperties":{"$dynamicRef":"#meta"},"deprecated":true,"default":{}},"dependencies":{"$comment":"\\"dependencies\\" has been split and replaced by \\"dependentSchemas\\" and \\"dependentRequired\\" in order to serve their differing semantics.","type":"object","additionalProperties":{"anyOf":[{"$dynamicRef":"#meta"},{"$ref":"meta/validation#/$defs/stringArray"}]},"deprecated":true,"default":{}},"$recursiveAnchor":{"$comment":"\\"$recursiveAnchor\\" has been replaced by \\"$dynamicAnchor\\".","$ref":"meta/core#/$defs/anchorString","deprecated":true},"$recursiveRef":{"$comment":"\\"$recursiveRef\\" has been replaced by \\"$dynamicRef\\".","$ref":"meta/core#/$defs/uriReferenceString","deprecated":true}}}')},98:e=>{"use strict";e.exports=JSON.parse('{"$schema":"http://json-schema.org/draft-07/schema#","$id":"http://json-schema.org/draft-07/schema#","title":"Core schema meta-schema","definitions":{"schemaArray":{"type":"array","minItems":1,"items":{"$ref":"#"}},"nonNegativeInteger":{"type":"integer","minimum":0},"nonNegativeIntegerDefault0":{"allOf":[{"$ref":"#/definitions/nonNegativeInteger"},{"default":0}]},"simpleTypes":{"enum":["array","boolean","integer","null","number","object","string"]},"stringArray":{"type":"array","items":{"type":"string"},"uniqueItems":true,"default":[]}},"type":["object","boolean"],"properties":{"$id":{"type":"string","format":"uri-reference"},"$schema":{"type":"string","format":"uri"},"$ref":{"type":"string","format":"uri-reference"},"$comment":{"type":"string"},"title":{"type":"string"},"description":{"type":"string"},"default":true,"readOnly":{"type":"boolean","default":false},"examples":{"type":"array","items":true},"multipleOf":{"type":"number","exclusiveMinimum":0},"maximum":{"type":"number"},"exclusiveMaximum":{"type":"number"},"minimum":{"type":"number"},"exclusiveMinimum":{"type":"number"},"maxLength":{"$ref":"#/definitions/nonNegativeInteger"},"minLength":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"pattern":{"type":"string","format":"regex"},"additionalItems":{"$ref":"#"},"items":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/schemaArray"}],"default":true},"maxItems":{"$ref":"#/definitions/nonNegativeInteger"},"minItems":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"uniqueItems":{"type":"boolean","default":false},"contains":{"$ref":"#"},"maxProperties":{"$ref":"#/definitions/nonNegativeInteger"},"minProperties":{"$ref":"#/definitions/nonNegativeIntegerDefault0"},"required":{"$ref":"#/definitions/stringArray"},"additionalProperties":{"$ref":"#"},"definitions":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"properties":{"type":"object","additionalProperties":{"$ref":"#"},"default":{}},"patternProperties":{"type":"object","additionalProperties":{"$ref":"#"},"propertyNames":{"format":"regex"},"default":{}},"dependencies":{"type":"object","additionalProperties":{"anyOf":[{"$ref":"#"},{"$ref":"#/definitions/stringArray"}]}},"propertyNames":{"$ref":"#"},"const":true,"enum":{"type":"array","items":true,"minItems":1,"uniqueItems":true},"type":{"anyOf":[{"$ref":"#/definitions/simpleTypes"},{"type":"array","items":{"$ref":"#/definitions/simpleTypes"},"minItems":1,"uniqueItems":true}]},"format":{"type":"string"},"contentMediaType":{"type":"string"},"contentEncoding":{"type":"string"},"if":{"$ref":"#"},"then":{"$ref":"#"},"else":{"$ref":"#"},"allOf":{"$ref":"#/definitions/schemaArray"},"anyOf":{"$ref":"#/definitions/schemaArray"},"oneOf":{"$ref":"#/definitions/schemaArray"},"not":{"$ref":"#"}},"default":true}')}},t={};function n(s){var r=t[s];if(void 0!==r)return r.exports;var i=t[s]={id:s,loaded:!1,exports:{}};return e[s].call(i.exports,i,i.exports,n),i.loaded=!0,i.exports}n.m=e,n.amdO={},n.n=e=>{var t=e&&e.__esModule?()=>e.default:()=>e;return n.d(t,{a:t}),t},n.d=(e,t)=>{for(var s in t)n.o(t,s)&&!n.o(e,s)&&Object.defineProperty(e,s,{enumerable:!0,get:t[s]})},n.u=e=>e+".js",n.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(e){if("object"==typeof window)return window}}(),n.hmd=e=>((e=Object.create(e)).children||(e.children=[]),Object.defineProperty(e,"exports",{enumerable:!0,set:()=>{throw new Error("ES Modules may not assign module.exports or exports.*, Use ESM export syntax, instead: "+e.id)}}),e),n.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),n.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},(()=>{var e;n.g.importScripts&&(e=n.g.location+"");var t=n.g.document;if(!e&&t&&(t.currentScript&&(e=t.currentScript.src),!e)){var s=t.getElementsByTagName("script");if(s.length)for(var r=s.length-1;r>-1&&!e;)e=s[r--].src}if(!e)throw new Error("Automatic publicPath is not supported in this browser");e=e.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),n.p=e})(),n.b=document.baseURI||self.location.href,n.nc=void 0;var s=n(7422);bio=s})();
9
9
  //# sourceMappingURL=package.js.map