@datagrok/bio 2.11.36 → 2.11.37
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- package/CHANGELOG.md +6 -0
- package/dist/package-test.js +1 -1
- package/dist/package-test.js.map +1 -1
- package/dist/package.js +1 -1
- package/dist/package.js.map +1 -1
- package/package.json +1 -1
- package/src/tests/msa-tests.ts +2 -2
- package/src/tests/pepsea-tests.ts +6 -3
- package/src/utils/helm-to-molfile.ts +3 -1
package/dist/package-test.js
CHANGED
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@@ -5,5 +5,5 @@ var bio_test;(()=>{var e={2012:(e,t,s)=>{"use strict";s.d(t,{f:()=>r});var n=s(9
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5
5
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|| ${a} === "boolean" || ${r} === null`).assign(l,o._`[${r}]`)}}n.else(),p(e),n.endIf(),n.if(o._`${l} !== undefined`,(()=>{n.assign(r,l),function({gen:e,parentData:t,parentDataProperty:s},n){e.if(o._`${t} !== undefined`,(()=>e.assign(o._`${t}[${s}]`,n)))}(e,l)}))}(e,t,a):p(e)}))}return c};const h=new Set(["string","number","integer","boolean","null"]);function u(e,t,s,n=l.Correct){const r=n===l.Correct?o.operators.EQ:o.operators.NEQ;let i;switch(e){case"null":return o._`${t} ${r} null`;case"array":i=o._`Array.isArray(${t})`;break;case"object":i=o._`${t} && typeof ${t} == "object" && !Array.isArray(${t})`;break;case"integer":i=a(o._`!(${t} % 1) && !isNaN(${t})`);break;case"number":i=a();break;default:return o._`typeof ${t} ${r} ${e}`}return n===l.Correct?i:(0,o.not)(i);function a(e=o.nil){return(0,o.and)(o._`typeof ${t} == "number"`,e,s?o._`isFinite(${t})`:o.nil)}}function d(e,t,s,n){if(1===e.length)return u(e[0],t,s,n);let r;const i=(0,a.toHash)(e);if(i.array&&i.object){const e=o._`typeof ${t} != "object"`;r=i.null?e:o._`!${t} || ${e}`,delete i.null,delete i.array,delete i.object}else r=o.nil;i.number&&delete i.integer;for(const e in i)r=(0,o.and)(r,u(e,t,s,n));return r}t.checkDataType=u,t.checkDataTypes=d;const m={message:({schema:e})=>`must be ${e}`,params:({schema:e,schemaValue:t})=>"string"==typeof e?o._`{type: ${e}}`:o._`{type: ${t}}`};function p(e){const t=function(e){const{gen:t,data:s,schema:n}=e,r=(0,a.schemaRefOrVal)(e,n,"type");return{gen:t,keyword:"type",data:s,schema:n.type,schemaCode:r,schemaValue:r,parentSchema:n,params:{},it:e}}(e);(0,i.reportError)(t,m)}t.reportTypeError=p},313:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.assignDefaults=void 0;const n=s(3487),r=s(6776);function i(e,t,s){const{gen:i,compositeRule:o,data:a,opts:l}=e;if(void 0===s)return;const c=n._`${a}${(0,n.getProperty)(t)}`;if(o)return void(0,r.checkStrictMode)(e,`default is ignored for: ${c}`);let h=n._`${c} === 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RegExp";const g=["removeAdditional","useDefaults","coerceTypes"],y=new Set(["validate","serialize","parse","wrapper","root","schema","keyword","pattern","formats","validate$data","func","obj","Error"]),b={errorDataPath:"",format:"`validateFormats: false` can be used instead.",nullable:'"nullable" keyword is supported by default.',jsonPointers:"Deprecated jsPropertySyntax can be used instead.",extendRefs:"Deprecated ignoreKeywordsWithRef can be used instead.",missingRefs:"Pass empty schema with $id that should be ignored to ajv.addSchema.",processCode:"Use option `code: {process: (code, schemaEnv: object) => string}`",sourceCode:"Use option `code: {source: true}`",strictDefaults:"It is default now, see option `strict`.",strictKeywords:"It is default now, see option `strict`.",uniqueItems:'"uniqueItems" keyword is always validated.',unknownFormats:"Disable strict mode or pass `true` to `ajv.addFormat` (or `formats` option).",cache:"Map is used as cache, schema object as key.",serialize:"Map is used as cache, schema object as key.",ajvErrors:"It is default now."},w={ignoreKeywordsWithRef:"",jsPropertySyntax:"",unicode:'"minLength"/"maxLength" account for unicode characters by default.'},C=200;function v(e){var t,s,n,r,i,o,a,l,c,h,u,d,m,g,y,b,w,v,T,A,S,_,E,P,$;const x=e.strict,N=null===(t=e.code)||void 0===t?void 0:t.optimize,M=!0===N||void 0===N?1:N||0,L=null!==(n=null===(s=e.code)||void 0===s?void 0:s.regExp)&&void 0!==n?n:f,I=null!==(r=e.uriResolver)&&void 0!==r?r:p.default;return{strictSchema:null===(o=null!==(i=e.strictSchema)&&void 0!==i?i:x)||void 0===o||o,strictNumbers:null===(l=null!==(a=e.strictNumbers)&&void 0!==a?a:x)||void 0===l||l,strictTypes:null!==(h=null!==(c=e.strictTypes)&&void 0!==c?c:x)&&void 0!==h?h:"log",strictTuples:null!==(d=null!==(u=e.strictTuples)&&void 0!==u?u:x)&&void 0!==d?d:"log",strictRequired:null!==(g=null!==(m=e.strictRequired)&&void 0!==m?m:x)&&void 0!==g&&g,code:e.code?{...e.code,optimize:M,regExp:L}:{optimize:M,regExp:L},loopRequired:null!==(y=e.loopRequired)&&void 0!==y?y:C,loopEnum:null!==(b=e.loopEnum)&&void 0!==b?b:C,meta:null===(w=e.meta)||void 0===w||w,messages:null===(v=e.messages)||void 0===v||v,inlineRefs:null===(T=e.inlineRefs)||void 0===T||T,schemaId:null!==(A=e.schemaId)&&void 0!==A?A:"$id",addUsedSchema:null===(S=e.addUsedSchema)||void 0===S||S,validateSchema:null===(_=e.validateSchema)||void 0===_||_,validateFormats:null===(E=e.validateFormats)||void 0===E||E,unicodeRegExp:null===(P=e.unicodeRegExp)||void 0===P||P,int32range:null===($=e.int32range)||void 0===$||$,uriResolver:I}}class T{constructor(e={}){this.schemas={},this.refs={},this.formats={},this._compilations=new Set,this._loading={},this._cache=new Map,e=this.opts={...e,...v(e)};const{es5:t,lines:s}=this.opts.code;this.scope=new c.ValueScope({scope:{},prefixes:y,es5:t,lines:s}),this.logger=function(e){if(!1===e)return x;if(void 0===e)return console;if(e.log&&e.warn&&e.error)return e;throw new Error("logger must implement log, warn and error methods")}(e.logger);const n=e.validateFormats;e.validateFormats=!1,this.RULES=(0,a.getRules)(),A.call(this,b,e,"NOT SUPPORTED"),A.call(this,w,e,"DEPRECATED","warn"),this._metaOpts=$.call(this),e.formats&&E.call(this),this._addVocabularies(),this._addDefaultMetaSchema(),e.keywords&&P.call(this,e.keywords),"object"==typeof e.meta&&this.addMetaSchema(e.meta),_.call(this),e.validateFormats=n}_addVocabularies(){this.addKeyword("$async")}_addDefaultMetaSchema(){const{$data:e,meta:t,schemaId:s}=this.opts;let n=m;"id"===s&&(n={...m},n.id=n.$id,delete n.$id),t&&e&&this.addMetaSchema(n,n[s],!1)}defaultMeta(){const{meta:e,schemaId:t}=this.opts;return this.opts.defaultMeta="object"==typeof e?e[t]||e:void 0}validate(e,t){let s;if("string"==typeof e){if(s=this.getSchema(e),!s)throw new Error(`no schema with key or ref "${e}"`)}else s=this.compile(e);const n=s(t);return"$async"in 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t;for(;"string"==typeof(t=S.call(this,e));)e=t;if(void 0===t){const{schemaId:s}=this.opts,n=new l.SchemaEnv({schema:{},schemaId:s});if(t=l.resolveSchema.call(this,n,e),!t)return;this.refs[e]=t}return t.validate||this._compileSchemaEnv(t)}removeSchema(e){if(e instanceof RegExp)return this._removeAllSchemas(this.schemas,e),this._removeAllSchemas(this.refs,e),this;switch(typeof e){case"undefined":return this._removeAllSchemas(this.schemas),this._removeAllSchemas(this.refs),this._cache.clear(),this;case"string":{const t=S.call(this,e);return"object"==typeof t&&this._cache.delete(t.schema),delete this.schemas[e],delete this.refs[e],this}case"object":{const t=e;this._cache.delete(t);let s=e[this.opts.schemaId];return s&&(s=(0,h.normalizeId)(s),delete this.schemas[s],delete this.refs[s]),this}default:throw new Error("ajv.removeSchema: invalid parameter")}}addVocabulary(e){for(const t of e)this.addKeyword(t);return this}addKeyword(e,t){let s;if("string"==typeof e)s=e,"object"==typeof 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l.SchemaEnv({schema:e,schemaId:o,meta:t,baseId:s,localRefs:c}),this._cache.set(a.schema,a),r&&!s.startsWith("#")&&(s&&this._checkUnique(s),this.refs[s]=a),n&&this.validateSchema(e,!0),a}_checkUnique(e){if(this.schemas[e]||this.refs[e])throw new Error(`schema with key or id "${e}" already exists`)}_compileSchemaEnv(e){if(e.meta?this._compileMetaSchema(e):l.compileSchema.call(this,e),!e.validate)throw new Error("ajv implementation error");return e.validate}_compileMetaSchema(e){const t=this.opts;this.opts=this._metaOpts;try{l.compileSchema.call(this,e)}finally{this.opts=t}}}function A(e,t,s,n="error"){for(const r in e){const i=r;i in t&&this.logger[n](`${s}: option ${r}. ${e[i]}`)}}function S(e){return e=(0,h.normalizeId)(e),this.schemas[e]||this.refs[e]}function _(){const e=this.opts.schemas;if(e)if(Array.isArray(e))this.addSchema(e);else for(const t in e)this.addSchema(e[t],t)}function E(){for(const e in this.opts.formats){const t=this.opts.formats[e];t&&this.addFormat(e,t)}}function P(e){if(Array.isArray(e))this.addVocabulary(e);else{this.logger.warn("keywords option as map is deprecated, pass array");for(const t in e){const s=e[t];s.keyword||(s.keyword=t),this.addKeyword(s)}}}function $(){const e={...this.opts};for(const t of g)delete e[t];return e}t.default=T,T.ValidationError=i.default,T.MissingRefError=o.default;const x={log(){},warn(){},error(){}},N=/^[a-z_$][a-z0-9_$:-]*$/i;function M(e,t){const{RULES:s}=this;if((0,d.eachItem)(e,(e=>{if(s.keywords[e])throw new Error(`Keyword ${e} is already defined`);if(!N.test(e))throw new Error(`Keyword ${e} has invalid name`)})),t&&t.$data&&!("code"in t)&&!("validate"in t))throw new Error('$data keyword must have "code" or "validate" function')}function L(e,t,s){var n;const r=null==t?void 0:t.post;if(s&&r)throw new Error('keyword with "post" flag cannot have "type"');const{RULES:i}=this;let o=r?i.post:i.rules.find((({type:e})=>e===s));if(o||(o={type:s,rules:[]},i.rules.push(o)),i.keywords[e]=!0,!t)return;const a={keyword:e,definition:{...t,type:(0,u.getJSONTypes)(t.type),schemaType:(0,u.getJSONTypes)(t.schemaType)}};t.before?I.call(this,o,a,t.before):o.rules.push(a),i.all[e]=a,null===(n=t.implements)||void 0===n||n.forEach((e=>this.addKeyword(e)))}function I(e,t,s){const n=e.rules.findIndex((e=>e.keyword===s));n>=0?e.rules.splice(n,0,t):(e.rules.push(t),this.logger.warn(`rule ${s} is not defined`))}function R(e){let{metaSchema:t}=e;void 0!==t&&(e.$data&&this.opts.$data&&(t=k(t)),e.validateSchema=this.compile(t,!0))}const O={$ref:"https://raw.githubusercontent.com/ajv-validator/ajv/master/lib/refs/data.json#"};function k(e){return{anyOf:[e,O]}}},4087:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(2577),r=s(996),i=s(5568),o=s(6795),a=s(235),l=s(2567),c=s(1233),h=s(1968),u=["/properties"];t.default=function(e){return[n,r,i,o,a,t(this,l),c,t(this,h)].forEach((e=>this.addMetaSchema(e,void 0,!1))),this;function t(t,s){return e?t.$dataMetaSchema(s,u):s}}},3510:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(4063);n.code='require("ajv/dist/runtime/equal").default',t.default=n},4499:(e,t)=>{"use strict";function s(e){const t=e.length;let s,n=0,r=0;for(;r<t;)n++,s=e.charCodeAt(r++),s>=55296&&s<=56319&&r<t&&(s=e.charCodeAt(r),56320==(64512&s)&&r++);return n}Object.defineProperty(t,"__esModule",{value:!0}),t.default=s,s.code='require("ajv/dist/runtime/ucs2length").default'},3589:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(540);n.code='require("ajv/dist/runtime/uri").default',t.default=n},7426:(e,t)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});class s extends Error{constructor(e){super("validation failed"),this.errors=e,this.ajv=this.validation=!0}}t.default=s},4783:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateAdditionalItems=void 0;const 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strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(412),r=s(3487),i=s(2141),o=s(6776),a={keyword:"additionalProperties",type:["object"],schemaType:["boolean","object"],allowUndefined:!0,trackErrors:!0,error:{message:"must NOT have additional properties",params:({params:e})=>r._`{additionalProperty: ${e.additionalProperty}}`},code(e){const{gen:t,schema:s,parentSchema:a,data:l,errsCount:c,it:h}=e;if(!c)throw new Error("ajv implementation error");const{allErrors:u,opts:d}=h;if(h.props=!0,"all"!==d.removeAdditional&&(0,o.alwaysValidSchema)(h,s))return;const m=(0,n.allSchemaProperties)(a.properties),p=(0,n.allSchemaProperties)(a.patternProperties);function f(e){t.code(r._`delete ${l}[${e}]`)}function g(n){if("all"===d.removeAdditional||d.removeAdditional&&!1===s)f(n);else{if(!1===s)return e.setParams({additionalProperty:n}),e.error(),void(u||t.break());if("object"==typeof s&&!(0,o.alwaysValidSchema)(h,s)){const s=t.name("valid");"failing"===d.removeAdditional?(y(n,s,!1),t.if((0,r.not)(s),(()=>{e.reset(),f(n)}))):(y(n,s),u||t.if((0,r.not)(s),(()=>t.break())))}}}function y(t,s,n){const r={keyword:"additionalProperties",dataProp:t,dataPropType:o.Type.Str};!1===n&&Object.assign(r,{compositeRule:!0,createErrors:!1,allErrors:!1}),e.subschema(r,s)}t.forIn("key",l,(s=>{m.length||p.length?t.if(function(s){let i;if(m.length>8){const e=(0,o.schemaRefOrVal)(h,a.properties,"properties");i=(0,n.isOwnProperty)(t,e,s)}else i=m.length?(0,r.or)(...m.map((e=>r._`${s} === ${e}`))):r.nil;return p.length&&(i=(0,r.or)(i,...p.map((t=>r._`${(0,n.usePattern)(e,t)}.test(${s})`)))),(0,r.not)(i)}(s),(()=>g(s))):g(s)})),e.ok(r._`${c} === ${i.default.errors}`)}};t.default=a},1125:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(6776),r={keyword:"allOf",schemaType:"array",code(e){const{gen:t,schema:s,it:r}=e;if(!Array.isArray(s))throw new Error("ajv implementation error");const i=t.name("valid");s.forEach(((t,s)=>{if((0,n.alwaysValidSchema)(r,t))return;const o=e.subschema({keyword:"allOf",schemaProp:s},i);e.ok(i),e.mergeEvaluated(o)}))}};t.default=r},19:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n={keyword:"anyOf",schemaType:"array",trackErrors:!0,code:s(412).validateUnion,error:{message:"must match a schema in anyOf"}};t.default=n},9864:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0});const n=s(3487),r=s(6776),i={keyword:"contains",type:"array",schemaType:["object","boolean"],before:"uniqueItems",trackErrors:!0,error:{message:({params:{min:e,max:t}})=>void 0===t?n.str`must contain at least ${e} valid item(s)`:n.str`must contain at least ${e} and no more than ${t} valid item(s)`,params:({params:{min:e,max:t}})=>void 0===t?n._`{minContains: ${e}}`:n._`{minContains: ${e}, maxContains: ${t}}`},code(e){const{gen:t,schema:s,parentSchema:i,data:o,it:a}=e;let l,c;const{minContains:h,maxContains:u}=i;a.opts.next?(l=void 0===h?1:h,c=u):l=1;const d=t.const("len",n._`${o}.length`);if(e.setParams({min:l,max:c}),void 0===c&&0===l)return void(0,r.checkStrictMode)(a,'"minContains" == 0 without "maxContains": "contains" keyword ignored');if(void 0!==c&&l>c)return(0,r.checkStrictMode)(a,'"minContains" > "maxContains" is always invalid'),void e.fail();if((0,r.alwaysValidSchema)(a,s)){let t=n._`${d} >= ${l}`;return void 0!==c&&(t=n._`${t} && ${d} <= ${c}`),void e.pass(t)}a.items=!0;const m=t.name("valid");function p(){const e=t.name("_valid"),s=t.let("count",0);f(e,(()=>t.if(e,(()=>function(e){t.code(n._`${e}++`),void 0===c?t.if(n._`${e} >= ${l}`,(()=>t.assign(m,!0).break())):(t.if(n._`${e} > ${c}`,(()=>t.assign(m,!1).break())),1===l?t.assign(m,!0):t.if(n._`${e} >= ${l}`,(()=>t.assign(m,!0))))}(s)))))}function f(s,n){t.forRange("i",0,d,(t=>{e.subschema({keyword:"contains",dataProp:t,dataPropType:r.Type.Num,compositeRule:!0},s),n()}))}void 0===c&&1===l?f(m,(()=>t.if(m,(()=>t.break())))):0===l?(t.let(m,!0),void 0!==c&&t.if(n._`${o}.length > 0`,p)):(t.let(m,!1),p()),e.result(m,(()=>e.reset()))}};t.default=i},7772:(e,t,s)=>{"use strict";Object.defineProperty(t,"__esModule",{value:!0}),t.validateSchemaDeps=t.validatePropertyDeps=t.error=void 0;const n=s(3487),r=s(6776),i=s(412);t.error={message:({params:{property:e,depsCount:t,deps:s}})=>{const r=1===t?"property":"properties";return n.str`must have ${r} ${s} when property ${e} is present`},params:({params:{property:e,depsCount:t,deps:s,missingProperty:r}})=>n._`{property: ${e},
|
|
6
6
|
missingProperty: ${r},
|
|
7
7
|
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n.functions.call("HELM:getMolFiles",{col:e}),h=function(e,t,s=!1){const n=new Array(e.length);for(let r=0;r<e.length;r++){let i=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(r);i=l.indexOf("\n",i)+1,i=l.indexOf("\n",i)+1,i=l.indexOf("\n",i)+1;const h=parseInt(l.substring(i,i+3)),u=parseInt(l.substring(i+3,i+6));a+=`M V30 COUNTS ${h} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<h;e++){i=l.indexOf("\n",i)+1+c,o=l.indexOf(" ",i);const n=l.substring(i,o);a+=s?`M V30 ${e+1} R${t.get(n)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(n)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<u;e++){i=l.indexOf("\n",i)+1;const t=parseInt(l.substring(i,i+3).trim()),s=parseInt(l.substring(i+3,i+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(i+6,i+9).trim())} ${t} ${s}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",n[r]=a}return n}(h,s,t);else{h=new Array(e.length);for(let n=0;n<e.length;n++){const e=u(o()(i.splitted[n]).filter((e=>""!==e)).toArray(),s,t);h[n]=e}}return r.Column.fromStrings("monomericMols",h)}function u(e,t,s=!1){let n="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";n+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,n+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++)n+=s?`M V30 ${r+1} R${t.get(e[r])} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(e[r])}\n`;n+="M V30 END ATOM\n",n+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)n+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return n+="M V30 END BOND\n",n+="M V30 END CTAB\n",n+="M END",n}},3348:(e,t,s)=>{"use strict";s.d(t,{_package:()=>rt,activityCliffs:()=>at,getBioLib:()=>ot,getHelmMonomers:()=>ut,getMonomerLibHelper:()=>it,importFasta:()=>ht,sequenceIdentityScoring:()=>dt,sequenceSimilarityScoring:()=>mt,sequenceSpaceTopMenu:()=>lt,toAtomicLevel:()=>ct});var n,r,i=s(4469),o=s(3870),a=s(976),l=s(4628);(r=n||(n={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";const c="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;var h=s(442),u=(s(5697),s(701)),d=s(3379),m=s.n(d),p=s(7795),f=s.n(p),g=s(569),y=s.n(g),b=s(3565),w=s.n(b),C=s(9216),v=s.n(C),T=s(4589),A=s.n(T),S=s(9414),_={};_.styleTagTransform=A(),_.setAttributes=w(),_.insert=y().bind(null,"head"),_.domAPI=f(),_.insertStyleElement=v(),m()(S.Z,_),S.Z&&S.Z.locals&&S.Z.locals;const E=e=>null==e;function P(e,t,s,n){if(s>e[e.length-1])return;const r=e.findIndex((e=>s<e));e.pop(),e.splice(r,0,s),t.pop(),t.splice(r,0,n)}class ${_workerCount;constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,i=[{}],o=[1],a=n.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,i,o,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),i.forEach(((e,t)=>i[t].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(23),s.b))));for(let s=0;s<this._workerCount;s++)u[s]=new Promise(((n,h)=>{const u=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=u&&n({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:s}),d[s].postMessage({values:e,startIdx:u,endIdx:m,threshold:r,fnNames:t,opts:i,weights:o,aggregationMethod:a}),d[s].onmessage=({data:{error:e,i:t,j:r,distance:i}})=>{e?(d[s].terminate(),h(e)):(d[s].terminate(),n({i:t,j:r,distance:i,idx:s}))}}));const m=await Promise.all(u),p=m.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(p),g=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,s,n={}){return await this.calcMultiColumn([e],[t],s,[n],[1])}async getKNN(e,t,s=15,n={}){return await this.multiColumnKNN([e],[t],s,[n],[1])}async getThresholdKNN(e,t,s=.8,n={}){return await this.multiColumnThresholdKnn([e],[t],s,[n],[1])}async multiColumnThresholdKnn(e,t,r=.8,i,o,a=n.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(427),s.b))));for(let s=0;s<this._workerCount;s++)h[s]=new Promise(((n,h)=>{const d=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=d&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[s].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,threshold:r,weights:o,aggregationMethod:a}),u[s].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[s].terminate(),h(e)):(u[s].terminate(),n({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),m=new Int32Array(e[0].length);for(const t of d)for(let s=0;s<e[0].length;++s)m[s]+=t.knnIndexes[s]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t])))};for(const t of d)for(let s=0;s<e[0].length;++s)for(let e=0;e<t.knnDistances[s]?.length;++e)p.knnDistances[s][m[s]-1]=t.knnDistances[s][e],p.knnIndexes[s][m[s]-1]=t.knnIndexes[s][e],m[s]-=1;return p}async multiColumnKNN(e,t,r=15,i,o,a=n.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(282),s.b))));for(let s=0;s<this._workerCount;s++)h[s]=new Promise(((n,h)=>{const d=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=d&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[s].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,nNeighbours:r,weights:o,aggregationMethod:a}),u[s].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[s].terminate(),h(e)):(u[s].terminate(),n({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),m={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let s=0;s<e[0].length;++s)for(let e=0;e<t.knnDistances[s]?.length;++e)P(m.knnDistances[s],m.knnIndexes[s],t.knnDistances[s][e],t.knnIndexes[s][e]);return m}async getSampleDistances(e,t,r=[],i,o=n.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(40),s.b))));try{const s=e[0].length*(e[0].length-1)/2,n=Math.floor(s/this._workerCount),l=1e6,c=Math.max(Math.min(s/1e3,l),Math.min(s,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*n,m=l===this._workerCount-1?s:(l+1)*n;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:h,fnNames:t,opts:r,weights:i,aggregationMethod:o}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}}));const d=await Promise.all(u),m=d.reduce(((e,t)=>e+t.distance.length),0),p=new Float32Array(m);let f=0;for(const e of d)p.set(e.distance,f),f+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,s=[],r,i=n.EUCLIDEAN){try{const n=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,s,r,i);return 1-o[Math.floor(7e7/n*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,s,n){const r=[],i=[],o=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=E(e[l])||E(e[c])?1:s(e[l],e[c]);1-t>=n&&(r.push(l),i.push(c),o.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(i),distance:new Float32Array(o)}}}var x,N=s(9657);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(x||(x={}));class M{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,s,n,r=x.none){var i;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(s),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(n),this.visibility=null!==(i=n.visibility)&&void 0!==i?i:new N.Z(this.lines.from.length),n.visibility||this.visibility.setAll(!0,!1),n.arrowSize&&(this.arrowWidth=n.arrowSize),this.canvas.onmousedown=e=>{-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,s,n,r,i,o,a,l,c,h,u,d;const m=this.sp.getOptions().look,p=this.lines.colors||this.lines.width||this.lines.opacities||this.lines.drawArrowsArr;p||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(s=this.lines.opacity)&&void 0!==s?s:1})`);const f=m.sizeColumnName?this.sp.dataFrame.col(m.sizeColumnName):null,g=this.sp.dataFrame.filter;for(let e=0;e<this.lines.from.length;e++)if(g.get(this.lines.from[e])&&g.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:s,sizeTo:g}=this.getMarkersSizes(m,f,e),y=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let b=null==y?void 0:y.x,w=null==y?void 0:y.y;const C=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let v=null==C?void 0:C.x,T=null==C?void 0:C.y;const A=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),b&&w&&v&&T&&Math.hypot(v-b,T-w)/A>.01){if(p){const t=(null===(n=this.lines.colors)||void 0===n?void 0:n[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:"0,128,0",s=(null===(i=this.lines.opacities)||void 0===i?void 0:i[e])?null===(o=this.lines.opacities)||void 0===o?void 0:o[e]:1;this.ctx.strokeStyle=`rgba(${t},${s})`,this.ctx.lineWidth=(null===(a=this.lines.widths)||void 0===a?void 0:a[e])?null===(l=this.lines.widths)||void 0===l?void 0:l[e]:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const m=this.multipleLinesCounts[e];let f=null;if(m){t=this.getLineLength(b,w,v,T);const n=this.getPointOnDistance(b,w,v,T,g,t),r=this.getPointOnDistance(v,T,b,w,s,t);b=n.x,w=n.y,v=r.x,T=r.y,f=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(m,b,w,v,T,e):this.findControlPoint(m,v,T,b,w,e),this.ctx.moveTo(b,w),this.ctx.quadraticCurveTo(f.x,f.y,v,T)}else this.ctx.moveTo(b,w),this.ctx.lineTo(v,T);if((null!==(c=this.lines.drawArrows)&&void 0!==c?c:null===(h=this.lines.drawArrowsArr)||void 0===h?void 0:h.getBit(e))&&(t||(t=this.getLineLength(b,w,v,T)),t>this.arrowWidth)){const e=m?null:this.getPointOnDistance(b,w,v,T,g,t),s=m?f.x:b,n=m?f.y:w;this.canvasArrow(this.ctx,null!==(u=null==e?void 0:e.x)&&void 0!==u?u:b,null!==(d=null==e?void 0:e.y)&&void 0!==d?d:w,s,n)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case x.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case x.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,s){let n=3,r=3;return t?(n=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[s]))/2,r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[s]))/2):e.markerDefaultSize&&(n=e.markerDefaultSize/2,r=e.markerDefaultSize/2),{sizeFrom:n,sizeTo:r}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e=new N.Z(this.lines.from.length);e.setAll(!0);for(let t=-1;-1!==(t=e.findNext(t));){const s=t,n=this.lines.from[s],r=this.lines.to[s];let i=1;for(let s=t;-1!==(s=e.findNext(s));){const t=this.lines.from[s],o=this.lines.to[s];(t===n&&o===r||o===n&&t===r)&&(this.multipleLinesCounts[s]=++i,e.setBit(s,!1,!1))}i>1&&(this.multipleLinesCounts[s]=1),e.setBit(t,!1,!1)}}checkCoordsOnLine(e,t){let s=-1,n=null,r=null;const i=this.sp.getOptions().look,o=i.sizeColumnName?this.sp.dataFrame.col(i.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let l=0;l<this.lines.from.length;l++)if(a.get(this.lines.from[l])&&a.get(this.lines.to[l])&&this.visibility.getBit(l)){const{sizeFrom:a,sizeTo:c}=this.getMarkersSizes(i,o,l),h=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[l]),this.yAxisCol.get(this.lines.from[l])),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[l]),this.yAxisCol.get(this.lines.to[l]));if(this.multipleLinesCounts[l]){const s=this.getLineLength(h.x,h.y,u.x,u.y),n=this.getPointOnDistance(h.x,h.y,u.x,u.y,c,s),i=this.getPointOnDistance(u.x,u.y,null==h?void 0:h.x,null==h?void 0:h.y,a,s),o=this.lines.from[l]>this.lines.to[l]?this.findControlPoint(this.multipleLinesCounts[l],n.x,n.y,i.x,i.y,l):this.findControlPoint(this.multipleLinesCounts[l],i.x,i.y,n.x,n.y,l);r=this.calculateDistToCurveLine(l,e,t,n,i,o)}else r=this.calculateDistToStraightLine(e,t,h,u);(!n&&null!==r&&r<5||n&&null!==r&&r<n)&&(n=r,s=l)}return s}calculateDistToStraightLine(e,t,s,n){const r=Math.min(s.x,n.x),i=Math.max(s.x,n.x),o=Math.min(s.y,n.y),a=Math.max(s.y,n.y);return e>=r-2&&e<=i+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,s,n):null}distToStraightLineSegment(e,t,s,n){const r=(e,t,s,n)=>Math.pow(e-s,2)+Math.pow(t-n,2),i=r(s.x,s.y,n.x,n.y);if(0==i)return r(e,t,s.x,s.y);let o=((e-s.x)*(n.x-s.x)+(t-s.y)*(n.y-s.y))/i;return o=Math.max(0,Math.min(1,o)),r(e,t,s.x+o*(n.x-s.x),s.y+o*(n.y-s.y))}calculateDistToCurveLine(e,t,s,n,r,i){const o=Math.min(n.x,r.x,i.x),a=Math.max(n.x,r.x,i.x),l=Math.min(n.y,r.y,i.y),c=Math.max(n.y,r.y,i.y);if(t>=o-2&&t<=a+2&&s>=l-2&&s<=c+2){const e=a-o,h=c-l;return this.calculateDistToCurveInRect(t,s,n,i,r,e,h)}return null}calculateDistToCurveInRect(e,t,s,n,r,i,o){const a=Math.floor((i+o)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const m=new N.Z(a);for(let i=0;i<c.length;i++){const o=i*l,a=Math.pow(1-o,2)*s.x+2*o*(1-o)*n.x+Math.pow(o,2)*r.x,m=Math.pow(1-o,2)*s.y+2*o*(1-o)*n.y+Math.pow(o,2)*r.y,p=Math.abs(e-a),f=Math.abs(t-m),g=p+f;(!d||d>g)&&(d=g),u[i]=Math.max(p,f),c[i]=a,h[i]=m}for(let e=0;e<c.length;e++)u[e]<d&&m.setBit(e,!0,!1);let p=null;for(let s=-1;-1!==(s=m.findNext(s));){const n=Math.hypot(c[s]-e,h[s]-t);(!p||p>n)&&(p=n)}return p}getLineLength(e,t,s,n){return Math.sqrt(Math.pow(s-e,2)+Math.pow(n-t,2))}getPointOnDistance(e,t,s,n,r,i){const o=s-r*((s-e)/i),l=n-r*((n-t)/i);return new a.Point(o,l)}findControlPoint(e,t,s,n,r,i){const o=t+(n-t)/2,l=s+(r-s)/2;let c=o-t,h=l-s;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(o+d/2*h,l-d/2*c):new a.Point(o-d/2*h,l+d/2*c)}canvasArrow(e,t,s,n,r){const i=Math.atan2(n-t,r-s)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(i-Math.PI/10),s-this.arrowWidth*Math.cos(i-Math.PI/10)),e.lineTo(t,s),e.lineTo(t-this.arrowWidth*Math.sin(i+Math.PI/10),s-this.arrowWidth*Math.cos(i+Math.PI/10))}}const L="dimensionality-reducer-terminate-event";var I=s(850);async function R(e,t,n,r,o,a,l){let c=await async function(e,t,n,r,o,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(s.p+s.u(42),s.b));u.postMessage({columnsData:e,distanceMetrics:t,method:n,options:a,weights:r,aggregationMethod:o});const d=i.events.onCustomEvent(L).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:e,embedding:t,epochNum:s,epochsLength:n}})=>{E(s)||E(n)?(d.unsubscribe(),e?h(e):c(t),setTimeout((()=>u.terminate()),100)):l&&l(s,n,t)}}))}(e,n,t,r,o,a,l);return c=c.map((e=>(0,I.Fv)(e))),c}let O=0;const k="cliffsDf",F=new u.Subject,D="activity_difference",G="SALI_index",H="similarity",W="line_index",B=["1_molecule","2_molecule"],V="filterCliffs";var U,j=s(499),Y=s(5226),K=s(7228),q=s(8457),Z=s(8260);async function z(e,t,s,n){const r=(0,q.O)(t),i=(0,Z.vU)(t.getTag(a.TAGS.UNITS),t.getTag("separator"))(s),o=n===U.IDENTITY?function(e,t){const s=t.columns.length,n=new Array(s),r=new Array(s),i=new Array(s);for(let o=0;o<s;++o){const s=t.columns.byIndex(o);n[o]=s.getRawData(),r[o]=s.categories.indexOf(""),i[o]=s.categories.indexOf(e[o]??"")}const o=a.Column.float("Identity",t.rowCount),l=o.getRawData();for(let s=0;s<t.rowCount;++s){l[s]=0;for(let t=0;t<e.length;++t)n[t][s]===i[t]&&++l[s];l[s]/=e.length}return o}(i,r):n===U.SIMILARITY?await async function(e,t){const s=t.columns.toList();return await(0,K.Qx)(s,e)}(i,r):null;if(null===o)throw new Error(`In bio library: Unkown sequence scoring method: ${n}`);return o.name=e.columns.getUnusedName(o.name),e.columns.add(o),o}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(U||(U={}));var X=s(7945),J=(s(4293),s(6414)),Q=s.n(J);const ee="rgb(100,100,100)",te="#808080",se="rgb(0,0,0)",ne=Z.GU;var re,ie;function oe(e,t,s,n,r,i,o=ee,a=0,l=!1,c=1,h="",u=!1,d=ie.classic,m=[],p=0,f=null,g=[],y=null,b={}){r.textAlign="start";let w=i.substring(0),C=u?"":h;d===ie.MSA&&(C="");let v=!0,T=!0,A="difference";null!=f&&null!=f.cell.column&&(v=f.cell.column.temp["color-code"]??!0,T=f.cell.column.temp["compare-with-current"]??!0,A=f.cell.column.temp["highlight-difference"]??"difference");const S=g[p];T&&g.length>0&&"difference"===A&&(c=w==S?.3:c),T&&g.length>0&&"equal"===A&&(c=w!=S?.3:c),null!=y&&(w=ne(w,y));const _=w+C;b[_]??(b[_]=r.measureText(_));let E=b[_];b[w]??(b[w]=r.measureText(w));let P=b[w].width;b[C]??(b[C]=r.measureText(C));const $=b[C].width,x=n/2-(E.fontBoundingBoxAscent+E.fontBoundingBoxDescent)/2+1;function N(s,n){const i=v?o:se;r.fillStyle=i,r.globalAlpha=c,d===ie.classic&&(r.fillText(w,e+s,t+x),r.fillStyle=te,r.fillText(C,e+n,t+x)),d===ie.MSA&&r.fillText(w,e+s,t+x)}E=E.width,d===ie.MSA&&(P=m[p],E=m[p]);const M=(m[p]??0)-(m[0]??0);if(l||E>s)return N(M,M+P),e+M+P+$;{const t=(s-E)/2;return N(t,t+P),e+M+t+P}}!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(re||(re={})),function(e){e.MSA="MSA",e.classic="classic"}(ie||(ie={})),s(9611);var ae,le,ce=s(8447),he=s(7331);function ue(e){const t=!Q().enumerate(e).some((([t,s])=>t.length>1&&0!=s&&s!=e.length-1)),s=[],n=t?"":" ";for(const[t,r]of Q().enumerate(e)){let i=t;r<e.length&&(i+=`${t?"":"-"}${n}`),s.push(i)}return[s,t]}(le=ae||(ae={})).long="long",le.short="short",s(3553),ce.GU;class de extends a.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const s=e.cell.column.temp["bio-seqCol"];if(!s)return;const n=e.bounds,r=t.offsetX-e.gridColumn.left+(e.gridColumn.left-n.x),a=s.getPosition(e.tableRowIndex,r),l=s.getSeqMonList(e.tableRowIndex);if(null!==a&&a<l.length){const e=l[a],n=[o.div(e)];if(s._monomerStructureMap[e])n.push(s._monomerStructureMap[e]);else{const t=s.getMonomer(e);if(t){const r={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=i.chem.svgMol(t.smiles,void 0,void 0,r);n.push(o),s._monomerStructureMap[e]=o}}o.tooltip.show(o.divV(n),t.x+16,t.y+16)}else o.tooltip.hide()}render(e,t,s,n,r,i,o){try{i.grid}catch(e){const[t,s]=(0,X.yf)(e);rt.logger.error(t,void 0,s)}i.cell.column}}class me extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return constants.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,s,n,r,i,o){const l=window.devicePixelRatio,c=i.grid,h=i.cell,u=i.tableColumn,d=h.value??"",m=u.tags.separator,p=u.tags[a.TAGS.UNITS];getUpdatedWidth(c,e,t,n,l);const[f,g]=d.split("#"),y=(0,Z.vU)(p,m);pe(e,t,s,n,r,y(f),y(g),p)}}function pe(e,t,s,n,r,i,o,a,l,c){if(i.length!==o.length){const e=function(e,t){let s=0,n=0;const r=e.length>t.length?e:t,i=e.length>t.length?t:e;for(let e=0;e<i.length;e++)r[e]===i[e]&&s++;const o=r.length-i.length;for(let e=r.length-1;e>o;e--)r[e]===i[e-o]&&n++;const a=new Array(Math.abs(e.length-t.length)).fill("");function l(e){return s>n?e.concat(a):a.concat(e)}return e.length>t.length?t=l(t):e=l(e),{subParts1:e,subParts2:t}}(Q()(i).toArray(),Q()(o).toArray());i=e.subParts1,o=e.subParts2}const h=e.measureText(ue(i).join("")),u=e.measureText(ue(o).join("")),d=Math.max(h.width,u.width);l&&(n=d+4*i.length,e.canvas.width=d+4*i.length);let m=Math.max(t,t+(n-(d+4*i.length))/2)+5;const p=Math.max(s,s+(r-28)/2);e.save(),e.beginPath(),e.rect(t,s,l?d+4*i.length:n,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=he.UE.Color;"HELM"!=a&&(f=(0,ce.py)(a.substring(a.length-2)));for(let t=0;t<i.length;t++){const s=i[t],a=o[t],l=f.get(s);if(s!=a){const i=f.get(a),o=oe(m,p-7,n,r,e,s,l,0,!0),h=oe(m,p+7,n,r,e,a,i,0,!0);m=Math.max(h,o),c&&(c[t]=fe(s,a,l,i,p,7,r))}else m=oe(m,p,n,r,e,s,l,0,!0,.5);m+=4}e.restore()}function fe(e,t,s,n,r,i,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(ue([e]).join("")).width,h=l.measureText(ue([t]).join("")).width,u=Math.max(c,h);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",oe(0,r-i,u,o,l,e,s,0,!0),oe(0,r+i,u,o,l,t,n,0,!0),a}var ge,ye=s(8467),be=s(9298);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ge||(ge={}));const we=new class{constructor(){this.regionTypes=[ge.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=be.ES.Entropy,this.filterSource=be.vS.filterSource}};var Ce=s(172),ve=s(8415);const Te=ge;var Ae,Se;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(Ae||(Ae={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(Se||(Se={}));const _e=we;class Ee extends a.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewerId=++Ee.viewerCounter,this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this._onRendered=new u.Subject,this.skipEmptyPositions=this.bool(Se.skipEmptyPositions,_e.skipEmptyPositions,{category:Ae.DATA}),this.regionTypes=this.stringList(Se.regionTypes,_e.regionTypes,{category:Ae.DATA,choices:Object.values(Te).filter((e=>e!=Te.Unknown))}),this.chains=this.stringList(Se.chains,_e.chains,{category:Ae.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(Se.fitWidth,_e.fitWidth,{category:Ae.LAYOUT}),this.positionWidth=this.float(Se.positionWidth,_e.positionWidth,{category:Ae.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(Se.positionHeight,_e.positionHeight,{category:Ae.LAYOUT,choices:Object.keys(be.ES)}),this.filterSource=this.string(Se.filterSource,_e.filterSource,{category:Ae.BEHAVIOR,choices:Object.values(be.Ct)}),this.viewSyncer=new Ce.c(rt.logger)}viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case Se.regionTypes:case Se.chains:this.setData(this.regions)}switch(e.name){case Se.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case Se.fitWidth:case Se.positionWidth:this.calcSize();break;case Se.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.positionHeight]:this.positionHeight});this.calcSize();break;case Se.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;rt.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}async destroyView(e){rt.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&o.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){rt.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),s=Array.from(new Set(t.map((e=>e.order)))).sort(),n=[];for(let e=0;e<s.length;e++)for(const r of this.chains){const i=t.find((t=>t.order==s[e]&&t.chain==r));n.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:i.sequenceColumnName,startPositionName:i.positionStartName,endPositionName:i.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(n);this.logos=new Array(s.length);for(let e=0;e<s.length;++e)this.logos[e]={};for(const[e,t,s]of r)this.logos[e][t]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=o.table(this.chains,(e=>[...s.length>0?[o.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((t=>{const s=this.logos[t][e];return s.root.style.height="100%",o.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((e=>t.find((t=>t.order==s[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=o.choiceInput("Data source",this.filterSource,Object.values(be.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=o.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),rt.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){rt.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let s=0;s<this.logos.length;s++){for(const t of this.chains)this.logos[s][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[s][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,s=13,n=9,r=(this.root.clientWidth-e-(this.logos.length-1)*n-s)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const s=this.logos[e][t];s.setOptions({[ve.bo.positionWidth]:r-s.positionMarginValue}),s.root.style.width=r*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(Se.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const s=this.chains[t];this.logos[e][s].setOptions({[ve.bo.filterSource]:this.filterSource})}}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,ye.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function Pe(e){const t=o.divH([],{style:{gap:"10px"}}),s=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",t.append(s),e.points.forEach((s=>{const n=o.divText(e.activityCol.get(s).toFixed(2));n.style.display="flex",n.style.justifyContent="left",n.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(s)),n]))})),t}function $e(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);e.points.forEach(((t,r)=>{s[r]=e.seqCol.get(t),n[r]=e.activityCol.get(t)}));const r={},i=j.Cn.getOrCreate(e.seqCol),a=i.getSplitter(),l=function(e,t,s,n){const r=document.createElement("canvas"),i=r.getContext("2d");return r.height=30,pe(i,0,0,0,30,e,t,s,!0,n),r}(a(s[0]),a(s[1]),i.units,r);return t.append(o.div(l,{style:{width:"300px",overflow:"scroll"}})),t.append(function(e){const t=o.div();if(Object.keys(e).length>0){const s=o.divV([]);s.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",s.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(s)}return t}(r)),t.append(xe("Activity delta",Math.abs(n[0]-n[1]))),t.append(xe("Cliff",e.sali)),t}function xe(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function Ne(e,t){const s=a.Column.string("seq_diff",e.rowCount).init((s=>`${e.get(t[0],s)}#${e.get(t[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(a.TAGS.UNITS,e.col(t[0]).getTag(a.TAGS.UNITS)),s.setTag("separator",e.col(t[0]).getTag("separator")),e.columns.add(s);const n=e.plot.grid();return n.col(t[0]).visible=!1,n.col(t[1]).visible=!1,n}Ee.viewerCounter=-1,s(708),s(6361),s(7983);class Me extends a.JsViewer{constructor(e){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[a.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",distance_metrics_methods.kg[0],{choices:distance_metrics_methods.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(o.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}s(7241),s(4004),s(9943),s(5393);var Le=s(7572),Ie=(s(3336),s(8710)),Re={};Re.styleTagTransform=A(),Re.setAttributes=w(),Re.insert=y().bind(null,"head"),Re.domAPI=f(),Re.insertStyleElement=v(),m()(Ie.Z,Re),Ie.Z&&Ie.Z.locals&&Ie.Z.locals,s(6584),s(3776),s(2428);var Oe,ke=function(e,t,s,n){return new(s||(s=Promise))((function(r,i){function o(e){try{l(n.next(e))}catch(e){i(e)}}function a(e){try{l(n.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof s?t:new s((function(e){e(t)}))).then(o,a)}l((n=n.apply(e,t||[])).next())}))};class Fe{constructor(e,t,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Fe.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let s=o.iconFA("clock");this._isAutomatic||0===t&&(s=o.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),i=o.divH([s,n],"grok-tutorial-entry");this._activity.append(i,r)}}_initRoot(){var e,t,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,n,""),(null===(t=null===(e=n.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return ke(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const i=s,a=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,i.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,n,a),yield(0,ye.gw)(a));const l=o.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return ke(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,s){return ke(this,void 0,void 0,(function*(){const n=o.div([],"demo-script-countdown");t.classList.add("hidden");let r=s/1e3;const i=this._createSVGIndicator(r);n.append(i),e.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(s),t}_changeStopState(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Fe.currentObject=null}step(e,t,s){return this._steps[this.steps.length]={name:e,func:t,options:s},this}start(){return ke(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Fe.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Oe||(Oe={}));var De=function(e,t,s,n){return new(s||(s=Promise))((function(r,i){function o(e){try{l(n.next(e))}catch(e){i(e)}}function a(e){try{l(n.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof s?t:new s((function(e){e(t)}))).then(o,a)}l((n=n.apply(e,t||[])).next())}))};s(7905),s(8341);var Ge=s(2568);s(525),s(9416),new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}};class He extends a.GridCellRenderer{get name(){return constants.Of.MONOMER}get cellType(){return constants.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,s,n,r,i,o){if(i.gridRow<0)return;MonomerTooltipHandler.getOrCreate(i.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,ce.py)(i.cell.column.getTag("alphabet")),l=i.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c,e.fillText((0,ce.GU)(l,6),t+n/2,s+r/2,n)}}class We extends a.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(e){this._properties=e}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(e){const[t,s]=(0,X.yf)(e);i.shell.error(t),this.logger.error(t,void 0,s)}}s(8770);class Be extends a.Widget{constructor(e){super(o.divV([])),this.viewed=!1,this.seqCol=e}async init(){const e=j.Cn.getOrCreate(this.seqCol),t=rt.properties.TooltipWebLogo,s=this.seqCol.getTag(be.DX.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer.detach(),super.detach()}}var Ve=s(922);class Ue{constructor(e,t){this.helmColumn=e,this.df=t,this.helmColumn=e}async convertToSmiles(){const e=await this.getSmilesList(),t=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(t,e.map((e=>null===e?"":e)))}async getSmilesList(){return(await this.convertToMolfileV2KColumn()).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}async convertToRdKitBeautifiedMolfileColumn(){const e=await this.getSmilesList(),t=await i.functions.call("Chem:getRdKitModule"),s=e.map((e=>{if(""===e)return null;const s=t.get_mol(e);return s?(s.normalize_depiction(1),s.straighten_depiction(!0),s):null})),n=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return a.Column.fromStrings(n,s.map((e=>null===e?"":e.get_molblock())))}async convertToMolfileV2KColumn(){const e=(await this.getPolymerGraphColumn()).toList().map(((e,t)=>{const s=this.helmColumn.get(t);if(!s)return"";let n="";try{n=this.getPolymerMolfile(s,e)}catch(e){const[t,s]=(0,X.yf)(e);rt.logger.error(t,void 0,s)}finally{return n}})),t=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",t,e)}async getPolymerGraphColumn(){return await i.functions.call("HELM:getMolfiles",{col:this.helmColumn})}getPolymerMolfile(e,t){const s=new je(t),n=new et(e);return s.monomerSymbols.forEach(((e,t)=>{const r=s.getMonomerShifts(t);n.addMonomer(e,t,r)})),n.compileToMolfile()}}class je{constructor(e){this.molfileHandler=Ve._.getInstance(e)}get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Ye{constructor(e,t){this.capGroupElements=[];const s=Le.A.instance.getBioLib().getMonomer(t,e);if(!s)throw new Error(`Monomer ${e} is not found in the library`);this.molfileWrapper=new ze(s.molfile,e),this.capGroupElements=s.rgroups.map((e=>(e.capGroupSMILES||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeBondedRGroups(e){this.molfileWrapper.removeRGroups(e)}capTrailingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ke{constructor(e,t,s){this.atoms=t,this.bonds=s,this.rGroupBondPositionMap=new Map,this.rGroupIdToAtomicIndexMap=this.getRGroupIdToAtomicIdxMap(e)}getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,s])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const s=this.bonds.getPositionsInBonds(t+1);if(0===s.length)throw new Error(`Cannot find position for R group ${e}`);if(s.length>1)throw new Error(`More than one position for R group ${e}`);const n=s[0];return this.bonds.replacePositionsInBondsByDummy([n]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),n}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,s]of this.rGroupIdToAtomicIndexMap)s>t&&this.rGroupIdToAtomicIndexMap.set(e,s-1)}getRGroupIdToAtomicIdxMap(e){const t=new Map;e.filter((e=>e.startsWith("M RGP"))).forEach((e=>{const s=function(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),s=new Array(t.length/2);for(let e=0;e<t.length;e+=2)s[e/2]=[t[e+1],t[e]-1];return s}(e);for(const[e,n]of s){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,n)}}));const s=e.map(((e,t)=>{if(e.startsWith("A "))return t})).filter((e=>void 0!==e)),n=s.map((t=>e[t])),r=s.map((t=>e[t+1]));n.forEach(((e,s)=>{const n=parseInt(e.split(/\s+/)[1])-1,i=parseInt(r[s].substring(1));if(t.has(i))throw new Error(`R group ${i} is already in the map`);t.set(i,n)}));const i=this.atoms.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==i.length)throw new Error(`Unaccounted R group indices: ${i}`);return t}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s}=t;this.bonds.deleteBondLines([s]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>s&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const s=this.rGroupBondPositionMap.get(e);if(!s)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:r}=s;this.bonds.bondedAtoms[n][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s,nodeIdx:n}=t;return this.bonds.bondedAtoms[s][(n+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,s)=>{const n=e[s-1];"H"===n?(this.removeRGroups([s]),this.deleteBondLineWithSpecifiedRGroup(s)):this.atoms.replaceElementSymbol(t,n)}))}}class qe{constructor(e){this.bondedPairs=[],this.rawBondLines=[],this.rawBondLines=e,this.bondedPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}get bondedAtoms(){return this.bondedPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,s)=>!e.includes(s))),this.bondedPairs=this.bondedPairs.filter(((t,s)=>!e.includes(s)))}getPositionsInBonds(e){const t=[];return this.bondedPairs.forEach(((s,n)=>{s.forEach(((s,r)=>{s===e&&t.push({bondLineIdx:n,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:s,nodeIdx:n}=e;this.bondedPairs[s][n]=t}))}removeAtomIdFromBonds(e){this.bondedPairs=this.bondedPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedPairs=this.bondedPairs.map((t=>t.map((t=>t+e))))}}class Ze{constructor(e){this.coordinates=[],this.rawAtomLines=[],this.rawAtomLines=e,this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomCoordinates(){return this.coordinates}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const s=this.coordinates[t];return`${s.x.toFixed(4).padStart(10," ")}${s.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}replaceElementSymbol(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,s)=>!e.includes(s))),this.rawAtomLines=this.rawAtomLines.filter(((t,s)=>!e.includes(s)))}shift(e){this.coordinates=this.coordinates.map((t=>{const s=t.x+e.x,n=t.y+e.y;if(isNaN(s)||isNaN(n))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:s,y:n}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const s=t.x,n=t.y,r=s*Math.cos(e)-n*Math.sin(e),i=s*Math.sin(e)+n*Math.cos(e);if(isNaN(r)||isNaN(i))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:i}}))}getRGroupAtomicIndices(){return this.rawAtomLines.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}}class ze{constructor(e,t){this.monomerSymbol=t;const s=e.split("\n"),n=parseInt(s[3].substring(0,3)),r=parseInt(s[3].substring(3,6)),i=s.slice(4,4+n);this.atoms=new Ze(i);const o=s.slice(4+n,4+n+r);this.bonds=new qe(o),this.rGroups=new Ke(s,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:s}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-s})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],s=t.y/t.x,n=Math.atan(s);if(isNaN(n))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-n)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}class Xe{constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:s}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=s}get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),s=[],n=[];return t.forEach((e=>{const t=e.split(/\(|\)/).map((e=>e.replace(/[\[\]]/g,"")));s.push(...t);const r=t.map(((e,t)=>t%2==0?0:1));n.push(...r)})),{monomers:s,monomerTypes:n}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if(0===e)return t})).filter((e=>void 0!==e)),s=this.monomerTypes.map(((e,t)=>{if(1===e)return t})).filter((e=>void 0!==e));for(let s=0;s<t.length-1;s++){const n=t[s],r=t[s+1];e.push([{monomerIdx:n,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<s.length;t++){const n=s[t],r=n-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:n,rGroupId:1}])}return e}}class Je{constructor(e){const t=e.split("|");t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}validateConnectionItem(e){const t="(PEPTIDE|RNA)",s=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(s))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const s=[],n=t.split(",");n[2].split("-").forEach(((e,t)=>{const r=n[t],i=e.split(":"),o={monomerIdx:parseInt(i[0])-1,rGroupId:parseInt(i[1].slice(1))};s.push({polymerId:r,bond:o})})),e.push(s)})),e}}class Qe{constructor(e){this.helm=e;const t=this.helm.split("$"),s=t[0].split("|");this.simplePolymers=s.map((e=>new Xe(e))),""!==t[1]&&(this.connectionList=new Je(t[1])),this.bondData=this.getBondData()}toString(){return this.helm}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),s=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===s)throw new Error(`Cannot find simple polymer for monomer ${e}`);const n=Object.keys(t).find((e=>t[e]===s));return this.simplePolymers.find((e=>e.id===n))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((s=>{e[s.id]=t,t+=s.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((s=>{const n=s.getBondData(),r=e[s.id];this.shiftBondMonomerIds(r,n),t.push(...n)})),this.connectionList&&this.connectionList.getConnectionData().forEach((s=>{const n=[];s.forEach((t=>{const s=e[t.polymerId],r=t.bond;r.monomerIdx+=s,n.push(r)})),t.push(n)})),t}}class et{constructor(e){this.monomerWrappers=[],this.helm=new Qe(e),this.bondedRGroupsMap=new Map,this.helm.bondData.forEach((e=>{e.forEach((e=>{const t=e.monomerIdx,s=e.rGroupId;this.bondedRGroupsMap.get(t)||this.bondedRGroupsMap.set(t,[]),this.bondedRGroupsMap.get(t).push(s)}))}))}addMonomer(e,t,s){const n=this.helm.getPolymerTypeByMonomerIdx(t),r=new Ye(e,n);r.shiftCoordinates(s),this.monomerWrappers.push(r)}removeRGroups(){this.monomerWrappers.forEach(((e,t)=>{this.bondedRGroupsMap.has(t)&&e.removeBondedRGroups(this.bondedRGroupsMap.get(t)),e.capTrailingRGroups()}))}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((s=>{e.push(t),t+=s.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),s=e.map((e=>e.rGroupId)),n=t.map((e=>this.monomerWrappers[e])),r=n[1].getAttachmentAtomByRGroupId(s[1]);n[0].replaceRGroupWithAttachmentAtom(s[0],r),n[1].deleteBondLineWithSpecifiedRGroup(s[1])}))}compileToMolfile(){const e=[],t=[];this.removeRGroups();const s=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(s[t])})),this.restoreBondsBetweenMonomers(),this.monomerWrappers.forEach((s=>{e.push(...s.getAtomLines()),t.push(...s.getBondLines())}));const n=e.length;if(n>999)throw new Error(`Atom count in polymer ${this.helm.toString()} is ${n} and exceeds 999`);const r=t.length;return["\nDatagrok\n",`${n.toString().padStart(3," ")}${r.toString().padStart(3," ")} 0 0 1 0 0 V2000`,e.join("\n"),t.join("\n"),"M END\n"].join("\n")}}s(1047),a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),["1","1A","1C","2","4","4A","4B","5","6"].join(ce.CI);var tt=s(8601),st=s(3277);function nt(e){const t=["Embed_X","Embed_Y"],s=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${s}`))}const rt=new We;function it(){return Le.A.instance}function ot(){return Le.A.instance.getBioLib()}async function at(e,t,n,r,u,d,m,p){if(!(0,Ge.n)(t,"Activity Cliffs"))return;const f=nt(e),g={units:t.getTag(a.TAGS.UNITS),aligned:t.getTag("aligned"),separator:t.getTag("separator"),alphabet:t.getTag("alphabet")},y=d,b=t,w=async()=>await async function(e,t,n,r,l,u,d,m,p,f,g,y,b,w,C,v){O++;const T=u/100;let A,S=!1;const _=y.inputs,E=await y.apply({[_[0].name]:t,[_[1].name]:d,...p.preprocessingFuncArgs??{}});let P=[];if(m===c){const t=await function(e,t,n,r,i,o,a=10){const l=new Worker(new URL(s.p+s.u(709),s.b));let c;return l.postMessage({data:e,threshold:t,weights:n,aggregationMethod:r,distanceFns:i,distanceFnArgs:o,maxIterations:a}),{promise:new Promise(((e,t)=>{c=e,l.onmessage=t=>{setTimeout((()=>l.terminate()),100),e(t.data.res)},l.onerror=e=>{setTimeout((()=>l.terminate()),100),t(e)}})),terminate:()=>{try{c(null),l.terminate()}catch(e){console.error(e)}}}}([E.entries],u,[1],"MANHATTAN",[d],[E.options??{}],p?.maxIterations??5).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),P=[t.embedX,t.embedY]}else P=await R([E.entries],m,[d],[1],"MANHATTAN",{...p,distanceFnArgs:[E.options??{}]});if(P.length!==n.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<P.length;++t)e.columns.addNewFloat(n[t]).init((e=>P[t][e]));const N=await(new $).calc(E.entries,d,T,E.options),L=await async function(e,t){const s=e.distance.map(((s,n)=>{const r=Math.abs(t.get(e.i[n])-t.get(e.j[n]));return 0!=s?r/s:1/0})),n=e.distance.map((e=>1-e)),r=e.i,i=e.j,o=new Set;return e.distance.forEach(((t,s)=>{o.add(e.i[s]),o.add(e.j[s])})),{simVals:n,saliVals:s,n1:r,n2:i,cliffsMolIds:o}}(N,l),I=function(e,t,s,n,r,i){const o=new Array(e).fill(0);for(let e=0;e!=s.length;++e)t[e]!=1/0&&(i.get(s[e])>i.get(n[e])?o[s[e]]+=t[e]:o[n[e]]+=t[e]);return a.Column.fromList("double",`sali_${r[0].substring(r[0].lastIndexOf("_"))}`,o)}(t.length,L.saliVals,L.n1,L.n2,n,l);e.columns.add(I);const U=function(e,t){const s=a.BitSet.create(e.rowCount);for(let n=0;n<e.rowCount;n++)s.set(n,t.has(n));return s}(e,L.cliffsMolIds),j=function(e){const t=e.filter((e=>e!==1/0)),s=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE),n=t.reduce(((e,t)=>Math.max(e,t)),s);return{max:n,min:s}}(L.saliVals),Y=.8/(j.max-j.min),K=i.shell.getTableView(e.name),q=K.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:n[0],yColumnName:n[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),Z=function(e,t,s,n,r,i,o,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let s=0;s<t.n1.length;s++)c.from[s]=t.n1[s],c.to[s]=t.n2[s],c.opacities[s]=t.saliVals[s]===1/0?1:.2+(t.saliVals[s]-o.min)*l,c.colors[s]=e.selection.get(c.from[s])&&e.selection.get(c.to[s])?"255,255,0":"0,128,0",c.widths[s]=1;const h=a.DataFrame.create(c.from.length);return B.forEach(((e,t)=>{h.columns.addNewString(e).init((e=>s.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((s=>{e.tags[s]=t[s]}))}(h.col(e),i),h.col(e).semType=r})),h.columns.addNewFloat(D).init((e=>Math.abs(n.get(c.from[e])-n.get(c.to[e])))),h.columns.addNewInt(W).init((e=>e)),h.columns.addNewFloat(G).init((e=>t.saliVals[e])),h.columns.addNewFloat(H).init((e=>t.simVals[e])),h.name=`${k}${O}`,{lines:c,linesDf:h}}(e,L,t,l,f,g,j,Y);Z.lines.skipMultiLineCalculation=!0,Z.linesDf.col(G).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const z=new M(q,n[0],n[1],Z.lines,x.none),X=C?C(Z.linesDf,B).sort([G],[!1]):Z.linesDf.plot.grid().sort([G],[!1]);X.col(W)&&(X.col(W).visible=!1),e.temp[".cliffsDfGrid"]=X;const J=o.button(`${Z.linesDf.rowCount} cliffs`,(()=>{K.dockManager.dock(X,"down",null,"Activity cliffs",v??.2)}));J.classList.add("scatter_plot_link","cliffs_grid"),q.root.append(J);const Q=o.switchInput("Show 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s=q.dataFrame.getSortedOrder(K.grid.sortByColumns,K.grid.sortTypes);K.grid.scrollToCell(t.name,s.indexOf(q.dataFrame.currentRowIdx))}),1e3)}})),Z.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<Z.linesDf.rowCount;e++){const s=Z.linesDf.selection.get(e);s&&(t.set(Z.lines.from[e],!0),t.set(Z.lines.to[e],!0)),Z.lines.colors[e]=s?"255,255,0":"0,128,0"}e.selection.copyFrom(t),z.linesToRender=Z.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<Z.lines.colors.length;e++)Z.lines.colors[e]="0,128,0";z.linesToRender=Z.lines})(X.dataFrame))})),z.lineClicked.subscribe((t=>{if(S=!0,z.currentLineId=t.id,-1!==t.id){const s=Z.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(s.set(t.id,!s.get(t.id)),Z.linesDf.selection.copyFrom(s)):(Z.linesDf.currentRowIdx!==t.id&&(Z.linesDf.currentRowIdx=t.id,e.currentRowIdx=Z.lines.from[t.id]),Z.linesDf.selection.copyFrom(s));const n=Z.linesDf.getSortedOrder(X.sortByColumns,X.sortTypes);X.scrollToCell(B[0],n.indexOf(t.id))}),500)}})),z.lineHover.pipe((0,h.debounceTime)(500)).subscribe((s=>{-1!==s.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(b({lineId:s.id,points:[Z.lines.from[s.id],Z.lines.to[s.id]],df:e,seqCol:t,activityCol:l}),s.x,s.y)})),q.addProperty("similarityLimit","double",T),A=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),i.shell.o=e.root,e}(),q}(e,b,f,"Activity cliffs",n,r,y,u,{...p??{}},a.SEMTYPE.MACROMOLECULE,g,m,Pe,$e,Ne),C=u===l.A.UMAP?2e5:2e4,v=u===l.A.UMAP?5e3:2e3;if(e.rowCount>C)return void i.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${C}`);const T=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,s)=>{e.rowCount>v&&!p?.[st.sS]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{w().then((e=>t(e))).catch((e=>s(e)))})).onCancel((()=>{t(void 0)})).show():w().then((e=>t(e))).catch((e=>s(e)))})).catch((e=>{const[t,s]=(0,X.yf)(e);throw rt.logger.error(t,void 0,s),e})).finally((()=>{T.close()}))}async function lt(e,t,n,r,l,c,h,u){if((0,Ge.n)(t,"Sequence Space"))return c||(c=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??(h={}),await async function(e,t,n,r,l,c,h,u=!0,d=!1,m={preprocessingFuncArgs:[]},p={}){const f={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==c.length||t.length!==l.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const g=i.shell.tableView(e.name)??i.shell.addTableView(e),y=async()=>{const y=a.TaskBarProgressIndicator.create(`Initializing ${p.scatterPlotName??"dimensionality reduction"} ...`);let b;try{const w=nt(e);function C(t,s,n){let r=null,i=null;e.columns.names().includes(w[0])?(r=e.columns.byName(w[0]),i=e.columns.byName(w[1])):(r=e.columns.add(a.Column.float(w[0],e.rowCount)),i=e.columns.add(a.Column.float(w[1],e.rowCount)),u&&!b&&(b=g.scatterPlot({...f,x:w[0],y:w[1],title:p.scatterPlotName??"Embedding space"}))),p[st.Ec]&&(b?.root&&o.setUpdateIndicator(b.root,!1),r.init((e=>n[0]?n[0][e]:void 0)),i.init((e=>n[1]?n[1][e]:void 0)));const l=t/s*100;y.update(l,`Running ${p.scatterPlotName??"dimensionality reduction"}... ${l.toFixed(0)}%`)}async function v(){e.columns.add(a.Column.float(w[0],e.rowCount)),e.columns.add(a.Column.float(w[1],e.rowCount));let s=null;u&&(b=g.scatterPlot({...f,x:w[0],y:w[1],title:p.scatterPlotName??"Embedding space"}),o.setUpdateIndicator(b.root,!0));const d=i.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&b?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===b?.getOptions()?.look?.title&&(i.events.fireCustomEvent(L,{}),d.unsubscribe(),s?.(),y.close())})),v=new Promise((async(e,i)=>{try{s=e;const i=[];for(let e=0;e<c.length;++e){const s=c[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),s){const n=s.inputs[0].name,o=s.inputs[1].name,{entries:a,options:l}=await s.apply({[n]:t[e],[o]:r[e],...m.preprocessingFuncArgs[e]??{}});i.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const s=t[e].toList(),n={};i.push({entries:s,options:n}),m.distanceFnArgs.push(n)}}e(await R(i.map((e=>e.entries)),n,r,l,h,m,p[st.sS]?void 0:C))}catch(e){i(e)}})),T=await v;return y.close(),d.unsubscribe(),T}const T=await v();if(d&&T){const A=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const S=await function(e,t,n,r){return De(this,void 0,void 0,(function*(){return new Promise((function(i,o){const a=new Worker(new URL(s.p+s.u(796),s.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:n}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):i(t)}}))}))}(T[0],T[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),_=e.columns.getUnusedName("Cluster");e.columns.addNewString(_).init((e=>S[e].toString())),b&&(b.props.colorColumnName=_)}catch(E){i.shell.error("Clustering embeddings failed"),console.error(E)}finally{A.close()}}if(T&&u&&b){o.setUpdateIndicator(b.root,!1);const P=e.columns.byName(w[0]),$=e.columns.byName(w[1]);return P.init((e=>T[0][e])),$.init((e=>T[1][e])),b.helpUrl="/help/compute/sequence-space",b}}catch(x){i.shell.error("Dimensionality reduction failed"),console.error(x),y.close(),b&&o.setUpdateIndicator(b.root,!1)}};return new Promise((async(t,s)=>{try{if(p.fastRowCount&&e.rowCount>p.fastRowCount&&!p[st.sS])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await y();t(e)}catch(e){s(e)}})).onCancel((()=>t(void 0))).show();else{const e=await y();t(e)}}catch(e){s(e)}}))}(e,[t],n,[r],[1],[c],"MANHATTAN",l,u??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[st.sS]})}async function ct(e,t,s){const n=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await async function(e,t,s){if(0===a.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(s){const s=j.Cn.getOrCreate(t);return s.isHelm()||(t=s.convert(ce.r2.HELM)),void async function(e,t){const s=await async function(e,t){const s=new Ue(t,e),n=await s.convertToRdKitBeautifiedMolfileColumn();return n.semType=a.SEMTYPE.MOLECULE,n}(e,t);e.columns.add(s,!0),await i.data.detectSemanticTypes(e)}(e,t)}if(!(0,Ge.n)(t,"To Atomic Level"))return;const n=it().getBioLib(),r=await(0,tt.i0)(e,t,n);null!==r.col&&(e.columns.add(r.col,!0),await i.data.detectSemanticTypes(e)),r.warnings&&r.warnings.length>0&&i.shell.warning(o.list(r.warnings))}(e,t,s)}finally{n.close()}}function ht(e){return new Y.i(e).importFasta()}function ut(e){const t=j.Cn.getOrCreate(e).stats;return Object.keys(t.freq)}async function dt(e,t,s){return z(e,t,s,U.IDENTITY)}async function mt(e,t,s){return z(e,t,s,U.SIMILARITY)}},7983:(e,t,s)=>{"use strict";s.d(t,{QF:()=>c,pf:()=>l});var n=s(4469),r=(s(3870),s(976)),i=s(7241),o=(s(4293),s(8467)),a=s(8447);function l(e,t,s){const n=s?function(e,t){const s=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),n=e.charAt(0)===t,r=e.charAt(e.length-1)===t,i=e.replace(new RegExp(`^${s}|${s}$`,"g"),"");return n?r?`${s}${i}${s}`:`${s}${i}${s}|${s}${i}$`:r?`^${i}${s}|${s}${i}${s}`:`^${i}${s}|${s}${i}${s}|${s}${i}$`}(e,s):e,i=r.BitSet.create(t.length);for(let s=0;s<t.length;s++){const r=t.get(s);(r.match(n)||r===e)&&i.set(s,!0,!1)}return i}async function c(e,t){t.version!==t.temp["last-invalidated-version"]&&await async function(e,t){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,o.gw)(10);const t=new Map,s=await(0,i.D)(e,!0,t);e.temp["monomeric-mols"]=s,e.temp["monomers-dict"]=t,e.temp["last-invalidated-version"]=e.version}finally{s.close()}}(t);const s=r.Column.string("helm",1).init((t=>e));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,a.r2.HELM);const l=await(0,i.D)(s,!0,t.temp["monomers-dict"]);return(await n.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:l.get(0),molBlockFailover:""})).get(0)}},2568:(e,t,s)=>{"use strict";s.d(t,{l:()=>a,n:()=>o});var n=s(4469),r=s(976),i=s(499);function o(e,t,s=[],r=[],i=!0){const[o,l]=a(e,t,s,r);return i&&!o&&n.shell.warning(l),o}function a(e,t,s=[],o=[]){let a=!0,l="";const c=i.Cn.getOrCreate(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)n.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},3553:(e,t,s)=>{"use strict";s.d(t,{Of:()=>i,WY:()=>h,jB:()=>u,mU:()=>a,rs:()=>c});var n,r,i,o=s(8341);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(n||(n={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(i||(i={}));const a="MSA";var l,c;!function(e){e.CELL_CHANGING="isCellChanging"}(l||(l={})),function(e){e.SEPARATOR="."}(c||(c={}));const h="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:o.Jy[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(e,t,s)=>{"use strict";s.d(t,{o:()=>i}),s(976),s(3870);var n=s(4469),r=(s(3336),s(8447),s(499));async function i(e,t,s){const i=r.Cn.getOrCreate(e).convert(t,s);e.dataFrame.columns.add(i);const o=await n.functions.call("Bio:detectMacromolecule",{col:i});return o&&(i.semType=o),await n.data.detectSemanticTypes(e.dataFrame),i}},7572:(e,t,s)=>{"use strict";s.d(t,{A:()=>h});var n=s(4469),r=s(6584),i=s(2832),o=s(3776),a=s(2428),l=s(3348);async function c(){const e=a.A.getInstance();return(await o.t.getInstance(e)).getValidLibraryPaths()}class h{constructor(){this._monomerLib=new i.B({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(e=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[t,s]=await Promise.all([c(),(0,r.nW)()]),n=t.filter((e=>{const t=!s.exclude.includes(e),n=0===s.explicit.length||s.explicit.includes(e);return t&&n})),o=await Promise.all(n.map((e=>this.readLibrary(r.BX,e).catch((t=>{const s=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new i.B({},s)})))));this._monomerLib.updateLibs(o,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;n.shell.warning(t);const s=e instanceof Error?e.stack:void 0;l._package.logger.error(t,void 0,s)}}))}async readLibrary(e,t){const s=a.A.getInstance(),n=await o.t.getInstance(s);return await n.loadLibraryFromFile(e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const s=await(0,r.nW)();s.exclude=(await c()).filter((t=>!e.includes(t))),await(0,r.tW)(s)}async getInvalidFileNames(e){const t=await c();return e.filter((e=>!t.includes(e)))}static get instance(){return window.$monomerLibHelper||(window.$monomerLibHelper=new h),window.$monomerLibHelper}}},2428:(e,t,s)=>{"use strict";s.d(t,{A:()=>i});var n=s(701),r=s(442);class i{constructor(){this._libraryFilesUpdateSubject$=new n.BehaviorSubject([]),this._addLibraryFilesSubject$=new n.Subject,this._librarySelectionSubject$=new n.Subject}static getInstance(){return i._instance||(i._instance=new i),i._instance}getValidFilesPathList(){return this._libraryFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{this._libraryFilesUpdateSubject$.pipe((0,r.skip)(1)).subscribe((t=>{e(t)}))}))}changeValidFilesPathList(e){this._libraryFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}},3776:(e,t,s)=>{"use strict";s.d(t,{t:()=>m});var n=s(4469),r=s(976),i=s(6584),o=s(2832),a=s(5128),l=s.n(a),c=s(3351),h=s.n(c);class u{constructor(e){this.helmMonomerSchema=e;const t=new(l())({allErrors:!0,strictTuples:!1});h()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const s=this.parseJson(e);return null!==s&&(Array.isArray(s)?this.validateJsonContent(s,t):(console.warn("Bio: Monomer Library File Validator: Invalid JSON format: The file must contain an array of monomers."),!1))}parseJson(e){try{return JSON.parse(e)}catch(e){return console.error("Bio: Monomer Library File Validator: Invalid JSON format:",e),null}}validateJsonContent(e,t){let s=!0;for(const n of e)if(s=this.validateMonomerSchema(n),!s){console.warn(`Bio: Monomer Library File Validator:\nfile ${t}\n monomer violating JSON schema:`,n,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}return s}}var d=s(7572);class m{constructor(e,t){this.libraryFileValidator=e,this.libraryEventManager=t,this.libraryEventManager.updateValidLibraryFileListRequested$.subscribe((async()=>{await this.updateValidLibraryList()}))}static async getInstance(e){return m.instancePromise||(m.instancePromise=(async()=>{const t=await n.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),s=JSON.parse(t),r=new u(s);return new m(r,e)})()),m.instancePromise}async addLibraryFile(e,t){try{if(await this.libraryFileExists(t))return void n.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await n.dapi.files.writeAsText(i.BX+`${t}`,e),await this.updateValidLibraryList(),await n.dapi.files.exists(i.BX+`${t}`)?n.shell.info(`Added ${t} HELM library`):n.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),n.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await n.dapi.files.delete(i.BX+`${e}`),await this.updateValidLibraryList(),n.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await n.dapi.files.exists(i.BX+`${e}`)?n.shell.error(`Failed to delete ${e} library`):n.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let s=[];const n=new r.FileSource(e),i=await n.readAsText(t);s=JSON.parse(i);const a={},l=[];return s.forEach((e=>{l.includes(e.polymerType)||(a[e.polymerType]={},l.push(e.polymerType)),a[e.polymerType][e.symbol]=e})),new o.B(a)}getValidLibraryPaths(){return this.libraryEventManager.getValidFilesPathList()}async getValidLibraryPathsAsynchronously(){return await this.libraryEventManager.getValidLibraryPathsAsynchronously()}async libraryFileExists(e){return await n.dapi.files.exists(i.BX+`${e}`)}async updateValidLibraryList(){const e=[],t=await this.getFilePathsAtDefaultLocation();if(!this.fileListHasChanged(t))return;for(const s of t){if(!s.endsWith(".json")){e.push(s);continue}const t=await n.dapi.files.readAsText(i.BX+`${s}`);this.isValidHELMLibrary(t,s)||e.push(s)}const s=t.filter((t=>!e.includes(t)));if(this.fileListHasChanged(s)&&(this.libraryEventManager.changeValidFilesPathList(s),d.A.instance.loadLibraries(!0)),s.some((e=>!e.endsWith(".json")))&&console.warn(`Wrong validation: ${s}`),e.length>0){const t=`Invalid monomer library files in ${i.BX}, consider fixing or removing them: ${e.join(", ")}`;console.warn(t)}}fileListHasChanged(e){const t=this.libraryEventManager.getValidFilesPathList();return e.length!==t.length||e.some(((e,s)=>e!==t[s]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.libraryFileValidator.validateFile(e,t)}async getFilePathsAtDefaultLocation(){const e=(await n.dapi.files.list(i.BX)).map((e=>e.fullPath)),t=[];for(const s of e)await n.dapi.files.exists(s)&&t.push(s);return t.map((e=>e.substring(i.BX.length)))}}},2832:(e,t,s)=>{"use strict";s.d(t,{B:()=>i});var n=s(701),r=s(922);class i{constructor(e,t){this._monomers={},this._onChanged=new n.Subject,this._monomers=e,this.error=t}getMonomer(e,t){return e in this._monomers&&t in this._monomers[e]?this._monomers[e][t]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((s=>{t[s]=this._monomers[e][s].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,s){let n=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return n=n.filter((e=>null!==e)),0===n.length?[]:(n=n.filter((t=>{if(!t?.rgroups)return!1;let s=t?.rgroups.length>=e;return r._.getInstance(t.molfile).atomTypes.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),s&&(s=!0),s})),n.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateInt(e){const 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t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var P=s(850);class ${static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,P.hu)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}$.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class x{constructor(e="categorial"){this.aa2num=$.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,s=e.length;const n=["NH2","COOH"];if(e.startsWith(n[0])){const s=n[0].length;(0,P.hu)("-"==e[s],`Wrong sequence format: ${n[0]} without following '-' in '${e}'.`),t=s}if(e.endsWith(n[1])){const t=n[1].length+1;(0,P.hu)("-"==e[s-t],`Wrong sequence format: ${n[1]} without '-' precending in '${e}'.`),s-=t}return e.substring(t,s)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return x._dropDefises(x._truncateSequence(e))}encode(e){const t=e.length,s=new Array(t).fill(0);for(let n=0;n<t;++n){const t=e[n];(0,P.hu)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),s[n]=this.encodeLettter(t)}return s}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let s=0;s<e.length;++s){const n=e[s];(0,P.hu)(n in this.num2aa,`Unknown code '${n}' found in vector '${e}'`),t+=this.num2aa[n]}return t}}var N=s(3553);const M="input.fa",L="result.fasta";function I(e){return e.reduce(((e,t,s)=>e+`>sample${s+1}\n${t}\n`),"")}async function R(e,t=!1,s="",i=null,o,a,l){let c=e.toList();t&&(c=c.map((e=>x.clean(e).replace(/\-/g,""))));const h=e.length;i??(i=n.Column.string("Clusters",h).init("0")),i.type!=n.COLUMN_TYPE.STRING&&(i=i.convertTo(n.TYPE.STRING)),i.compact();const u=i.categories,d=i.getRawData(),m=new Array(u.length),p=new Array(u.length);for(let e=0;e<h;++e){const t=d[e];(m[t]??(m[t]=[])).push(c[e]),(p[t]??(p[t]=[])).push(e)}const f=await new E(["base/1.0.0",{tool:"kalign",version:N.WY,reinit:!0}]),g=n.Column.string(s,h);for(let e=0;e<u.length;++e){const t=I(m[e]);await f.fs.writeFile(M,t);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,n=await f.exec(`kalign ${M} -f fasta -o ${L}${s}`);console.warn(n);const i=await f.cat(L);if(!i)throw new Error("kalign output no result");const c=new r.i(i).sequencesArray,h=p[e];for(let e=0;e<c.length;++e)g.set(h[e],c[e])}const y=e.getTag(n.TAGS.UNITS),b=e.getTag("alphabet");return 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n=f.indexOf(s),r=e.get(t);r&&(g[n]??(g[n]=[])).push({ID:t.toString(),HELM:r})}const y=new Array(p);for(const e of g){const t=(await u(m.id,e,s,l,h)).Alignment;for(const e of t)y[parseInt(e.ID)]=Object.entries(e).filter((e=>!c.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(o.rs.SEPARATOR)}const b=r.Column.fromStrings(t,y);return b.setTag(r.TAGS.UNITS,i.r2.SEPARATOR),b.setTag("separator",o.rs.SEPARATOR),b.setTag("aligned","SEQ.MSA"),b.setTag("alphabet","UN"),b.setTag(".alphabetIsMultichar","true"),b.semType=r.SEMTYPE.MACROMOLECULE,b}async function u(e,t,s,r,i){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},a=`/align?method=${s}&gap_open=${r}&gap_extend=${i}`,l=await n.dapi.docker.dockerContainers.request(e,a,o);return JSON.parse(l??"{}")}},9943:(e,t,s)=>{"use strict";s.d(t,{i$:()=>a,sK:()=>l}),s(976),s(3870),s(4469);var n=s(6414),r=s.n(n),i=s(8447);s(499);const o=60;function a(e,t,s=o,n="\n"){const 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i.Point((e.clientX-s.left)*t,(e.clientY-s.top)*t)},i.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class T{constructor(e=0,t){this.valueList=null,this.valueIdx=0,this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class A{get label(){return this._label?this._label:this.name}constructor(e,t,s,n){this.sumRowCount=0,this.pos=e,this.name=t,this._freqs=s??{},n?.sumRowCount&&(this.sumRowCount=n.sumRowCount),n?.sumValueForHeight&&(this.sumPlotValue=n.sumValueForHeight),n?.label&&(this._label=n.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new T),t}aggregate(e){const t=function(e){return t=>{const s=function(e){let t;const s="agg";return t=e instanceof 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d=h*c+(n-u-1);const p=Object.entries(this._freqs).sort(((t,s)=>e(t[0])||e(s[0])?e(t[0])&&e(s[0])?0:e(t[0])?-1:1:s[1].value-t[1].value));for(const[e,n]of p){const e=u*n.plotValue/this.sumPlotValue;n.bounds=new i.Rect((t-s)*c*a,d,l*c,e),d+=e}}render(e,t,s,n,r,i){for(const[o,a]of Object.entries(this._freqs))if(!t(o)){const t=(0,d.GU)(o,5),l=a.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=i.get(o)??i.get("other"),e.textAlign="left",e.font=s;const h=e.measureText(t);e.setTransform(l.width/h.width,0,0,l.height/r,c,l.top),e.fillText(t,0,-n)}}getMonomerAt(e,t){const s=Object.entries(this._freqs).find((([s,n])=>n.bounds.contains(e,t)));return s?s[0]:void 0}buildCompositionTable(e){return(0,C._)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(w||(w={}));const S=m.vS;var _;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(_||(_={}));const E=new class{constructor(){this.render=20}};class P extends i.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===m.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===m.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.initialized=!1,this.palette=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewerId=++P.viewerCounter,this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new h.Subject,this._onFreqsCalculated=new h.Subject,this._onLayoutCalculated=new h.Subject,this.requestedRenderLevel=_.Freqs,this.renderRequest=new h.Subject,this._onRendered=new h.Subject,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(w.sequenceColumnName,S.sequenceColumnName,{category:b.DATA});const e=[i.AGG.KEY,i.AGG.PIVOT,i.AGG.MISSING_VALUE_COUNT,i.AGG.SKEW,i.AGG.KURT,i.AGG.SELECTED_ROWS_COUNT],t=Object.values(i.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(w.valueAggrType,S.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(w.valueColumnName,S.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(w.startPositionName,S.startPositionName,{category:b.DATA}),this.endPositionName=this.string(w.endPositionName,S.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(w.skipEmptySequences,S.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(w.skipEmptyPositions,S.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(w.shrinkEmptyTail,S.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(w.backgroundColor,S.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(w.positionHeight,S.positionHeight,{category:b.STYLE,choices:Object.values(m.ES)}),this._positionWidth=this.positionWidth=this.float(w.positionWidth,S.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(w.verticalAlignment,S.verticalAlignment,{category:b.LAYOUT,choices:Object.values(m.vw)}),this.horizontalAlignment=this.string(w.horizontalAlignment,S.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(m.iD)}),this.fixWidth=this.bool(w.fixWidth,S.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(w.fitArea,S.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(w.minHeight,S.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(w.maxHeight,S.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(w.showPositionLabels,S.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(w.positionMarginState,S.positionMarginState,{category:b.LAYOUT,choices:Object.values(m.dE)});let s=0;"auto"===this.positionMarginState&&(s=4),this.positionMargin=this.int(w.positionMargin,s,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(w.filterSource,S.filterSource,{category:b.BEHAVIOR,choices:Object.values(m.Ct)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.c(v._package.logger)}viewerToLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.viewerToLog()}.setData()`;v._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),v._package.logger.debug(`${e}, out`)}async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(i.debounce(this.renderRequest,E.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(_.Freqs,"buildView"),v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(_.Layout,"rootOnSizeChanged")}updateEditors(){this.props.getProperty(w.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=u.Cn.getOrCreate(this.seqCol),this.palette=(0,d.dQ)(this.seqCol),this.render(_.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case m.Ct.Filtered:e=this.dataFrame.filter;break;case m.Ct.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=m.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=s*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${n}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+6}px`),this.host.style.width=`${this.host}px`;const r=t>n;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+s,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-s),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=s*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/s,i=Math.max(1,Math.min(n,r));this._positionWidth=this.positionWidth*i,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=i*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=o>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+s,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-s),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case w.sequenceColumnName:this.updateSeqCol();break;case w.sequenceColumnName:case w.startPositionName:case w.endPositionName:case w.filterSource:case w.shrinkEmptyTail:case w.skipEmptyPositions:case w.positionHeight:case w.valueColumnName:case w.valueAggrType:this.render(_.Freqs,`onPropertyChanged( ${e.name} )`);break;case w.minHeight:case w.maxHeight:case w.positionWidth:case w.showPositionLabels:case w.fixWidth:case w.fitArea:case w.horizontalAlignment:case w.verticalAlignment:case w.positionMargin:case w.positionMarginState:this.render(_.Layout,`onPropertyChanged(${e.name})`);break;case w.backgroundColor:this.render(_.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.viewerToLog()}.detach()`;v._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),v._package.logger.debug(`${e}, out`)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const s=e.x,n=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[n];if(!r)return[null,null,null];const i=r.getMonomerAt(s,e.y);return void 0===i?[r,null,null]:[r,i,r.getFreq(i)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>{const t=this.unitsHandler.defaultGapSymbol;return!e.hasMonomer(t)||e.getFreq(t).rowCount!==e.sumRowCount})).toArray())}render(e,t){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,s=this.showPositionLabels?12:0;if(e>=_.Freqs&&(()=>{if(v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.getFilter(),t=0===e.trueCount?this.unitsHandler.maxLength:c().enumerate(this.unitsHandler.splitted).map((([t,s])=>e.get(s)&&t?t.length:0)).reduce(((e,t)=>Math.max(e,t)),0),s=this.seqCol.getTag(".positionNames"),n=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(d.CI).map((e=>e.trim())):[...Array(t).keys()].map((e=>`${e+1}`)),this.positionLabels=n?n.split(d.CI).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):t-1;const r=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=u.Cn.getOrCreate(this.seqCol);const o=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(o);for(let e=0;e<r;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new A(this.startPosition+e,t,{},{label:s})}const a=this.dataFrame.rowCount,l=this.unitsHandler.splitted;for(let t=0;t<r;++t){for(let s=0;s<a;++s)if(e.get(s)){const e=l[s][this.startPosition+t]||this.unitsHandler.defaultGapSymbol,n=this.positions[t],r=n.getFreq(e);++n.sumRowCount,r.value=++r.rowCount}if(this.valueAggrType===i.AGG.TOTAL_COUNT)continue;let s=null;try{s=this.dataFrame.getCol(this.valueColumnName),s.matches("numerical")||(s=null)}catch{s=null}if(s){for(let n=0;n<a;++n)if(e.get(n)){const e=l[n][this.startPosition+t]||this.unitsHandler.defaultGapSymbol,r=s.get(n);this.positions[t].getFreq(e).push(r)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===i.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<r;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),o=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=_.Layout&&((e,t,s,r)=>{v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const o=this.canvas.height-r*s;let a;if(this.valueAggrType===i.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==m.ES.Entropy&&null==e&&n.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let n=e;n<=t;++n)n in this.positions?this.positions[n].calcScreen((e=>this.unitsHandler.isGap(e)),n,this.slider.min,o,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,s,r):v._package.logger.warning(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${n}`);v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,o,window.devicePixelRatio,s);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=i.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,s>0&&this.positions.length>0&&function(e,t,s,n,r,i,o,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(o);t<=Math.floor(a);t++){const s=i[t],n=e.measureText(s.name),r=n.actualBoundingBoxDescent-n.actualBoundingBoxAscent;l=null===l?n.width:Math.max(l,n.width),c=null===c?r:Math.max(c,r)}const h=l<n*t-2?1:(n*t-2)/l;for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=i[l],u=(l-o)*s*t+n*t/2,d=(r*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,s,this.positions,this.slider.min,this.slider.max);const n="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=o;e++)this.positions[e].render(a,(e=>this.unitsHandler.isGap(e)),n,l,c,this.palette)}finally{a.restore()}v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.viewerToLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=_.None,this.renderInt(e).catch((e=>{const[t,s]=(0,f.yf)(e);v._package.logger.error(t,void 0,s)}))):v._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(_.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.filterSource===m.Ct.Filtered&&this.render(_.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===m.Ct.Selected&&this.render(_.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const s=e,n=this.canvas.getCursorPosition(s,t),[o,a]=this.getMonomer(n,t),l=this.showPositionLabels?12*t:0;if(null!==o&&null===a&&0<=n.y&&n.y<=l){const e=[r.divText(`Position ${o.label}`)];this.valueAggrType===i.AGG.TOTAL_COUNT&&e.push(o.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,s.x+16,s.y+16)}else if(null!==o&&a&&this.dataFrame&&this.seqCol&&this.unitsHandler){const e=o.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==i.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const n=r.divV(t);r.tooltip.show(n,s.x+16,s.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,s=window.devicePixelRatio,[n,r]=this.getMonomer(this.canvas.getCursorPosition(t,s),s);if(null!==n&&null!==r&&this.dataFrame&&this.seqCol&&this.unitsHandler){const e=i.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,s,n,r,i){const o=t.splitted[n],a=i.pos<o.length?o[i.pos]:null;return a===r||""===a&&r===t.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.getFilter(),e,r,n)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*t),n=e.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+n)}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+t)}}get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,s=`${this.viewerToLog()}.${t}`;this.viewSyncer.sync(`${s}`,(async()=>{this.render(_.None,t),this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function $(e,t,s,n,r){let i=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const e=t.splitted[o],s=r.pos;(s<e.length?e[s]:null)===n&&i++}return i}P.residuesSet="nucleotides",P.viewerCounter=-1},8755:(e,t,s)=>{"use strict";s.d(t,{Y:()=>o,x:()=>i});var n=s(701),r=s(3348);class i{get onChanged(){return this._onChanged}constructor(e){return this.substructure=e,this._onChanged=new n.Subject,new Proxy(this,{set:(e,t,s)=>(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${s}' )`),e[t]=s,this._onChanged.next(),!0)})}save(){const e={};for(const[t,s]of Object.entries(this))"_onChanged"!==t&&(e[t]=this[t]);return e}apply(e){for(const[t,s]of Object.entries(this))"_onChanged"!==t&&(this[t]=e[t])}}class o{constructor(){this.onChanged=new n.Subject,this._propsChanging=!1,this._propsOnChangedSub=null}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._propsOnChangedSub&&(this._propsOnChangedSub.unsubscribe(),this._propsOnChangedSub=null),this._props=e,this.applyProps(),this.onChanged.next(),this._propsOnChangedSub=this._props.onChanged.subscribe((()=>{this.onChanged.next()}))}finally{this._propsChanging=!1}}async detach(){this._propsOnChangedSub&&(this._propsOnChangedSub.unsubscribe(),this._propsOnChangedSub=null)}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},5393:(e,t,s)=>{"use strict";s.d(t,{ST:()=>S,LH:()=>A});var n=s(3870),r=s(976),i=s(4469),o=s(6414),a=s.n(o),l=s(701),c=s(8447),h=s(8467),u=s(499),d=s(172),m=s(7983),p=s(8755),f=s(3336),g=s.n(f),y=s(7945),b=s(4293),w=s(3348);class C extends p.Y{viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.viewerId=++C.viewerCounter,this.viewSubs=[],this.logger=w._package.logger}async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await async function(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}();let t,s;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await n.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=n.div(),s=e.createWebEditorApp(t,this.props.substructure),n.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.x(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,s=null}})).onCancel((()=>{g()(t).empty(),t=null,s=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(n.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(s){const e=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,s]=(0,y.yf)(e);this.logger.error(t,void 0,s)}})))}catch(e){const[t,s]=(0,y.yf)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),n.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=t/2;if(e)(0,b.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,s);else{const e=n.divText("Click to edit","helm-substructure-filter");(0,b.Y)(this._filterPanel,e)}}async substructureSearch(e){return await(0,h.gw)(10),await(0,m.QF)(this.props.substructure,e)}}C.viewerCounter=-1;const v="bio-substructure-filter";class T{constructor(e,t,s,n,r){this.props=e,this.filterId=t,this.dataFrameId=s,this.columnName=n,this.bitset=r}}class A extends p.x{constructor(e,t){super(e),this.separator=t}}class S extends r.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.bioFilter=null,this.bitset=null,this.notation=void 0,this.filterId=++S.filterCounter,this.viewSubs=[],this._onRendered=new l.Subject,this.root=n.divV([]),this.loader=n.loader(),this.calculating=!1,this.filterSyncer=new d.c(this.logger=w._package.logger),new Proxy(this,{set:(e,t,s)=>(e[t]=s,!0)})}filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}attach(e){const t=super.attach.bind(this),s=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(s,(async()=>{t(e),this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE),u.Cn.getOrCreate(this.column),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(r.TAGS.UNITS)),this.bioFilter=this.notation===c.r2.FASTA?new _:this.notation===c.r2.SEPARATOR?new E(this.column.getTag("separator")):new C,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(i.events.onResetFilterRequest.subscribe((e=>{this.bioFilter?.resetFilter()}))),this.viewSubs.push(i.events.onCustomEvent(v).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=super.saveState();return e.props=this.bioFilter.props.save(),e}applyState(e){super.applyState(e),e.props&&this.bioFilter.props.apply(e.props)}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;w._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.props.save())}`:"")),i.events.fireCustomEvent(v,new T(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(w._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.props.save())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{w._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),w._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,w._package.logger.debug(`${e}, end`)}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} 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s={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:4}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:4}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:282},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(s))(0,t.Bu)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const s=t.getCol("seq"),n=new D.A(null,s,(()=>({unitsHandler:h.Cn.getOrCreate(s),monomerCharWidth:7,separatorWidth:12,monomerToShort:c.GU,monomerLengthLimit:3}))),i=r.testList;for(let e=0;e<s.length;++e)n.getCellMonomerLengths(e);const o=[];for(const[e,t]of F().enumerate(i)){const t={pos:n.getPosition(e.src.row,e.src.x)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", n"))}))})),(0,t.W3)("converters",(()=>{let s;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(s||(s={}));const n={[s.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[s.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[s.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[s.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[s.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[s.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[s.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[s.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[s.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[s.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[s.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[s.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[s.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[s.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[s.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[s.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[s.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[s.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"};async 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8
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n.functions.call("HELM:getMolFiles",{col:e}),h=function(e,t,s=!1){const n=new Array(e.length);for(let r=0;r<e.length;r++){let i=0,o=0,a="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";const l=e.get(r);i=l.indexOf("\n",i)+1,i=l.indexOf("\n",i)+1,i=l.indexOf("\n",i)+1;const h=parseInt(l.substring(i,i+3)),u=parseInt(l.substring(i+3,i+6));a+=`M V30 COUNTS ${h} ${u} 0 0 0\n`,a+="M V30 BEGIN ATOM\n";for(let e=0;e<h;e++){i=l.indexOf("\n",i)+1+c,o=l.indexOf(" ",i);const n=l.substring(i,o);a+=s?`M V30 ${e+1} R${t.get(n)} 0.000 0.000 0 0\n`:`M V30 ${e+1} At 0.000 0.000 0 0 MASS=${t.get(n)}\n`}a+="M V30 END ATOM\n",a+="M V30 BEGIN BOND\n";for(let e=0;e<u;e++){i=l.indexOf("\n",i)+1;const t=parseInt(l.substring(i,i+3).trim()),s=parseInt(l.substring(i+3,i+6).trim());a+=`M V30 ${e+1} ${parseInt(l.substring(i+6,i+9).trim())} ${t} ${s}\n`}a+="M V30 END BOND\n",a+="M V30 END CTAB\n",a+="M END",n[r]=a}return n}(h,s,t);else{h=new Array(e.length);for(let n=0;n<e.length;n++){const e=u(o()(i.splitted[n]).filter((e=>""!==e)).toArray(),s,t);h[n]=e}}return r.Column.fromStrings("monomericMols",h)}function u(e,t,s=!1){let n="\n Datagrok macromolecule handler\n\n 0 0 0 0 0 0 999 V3000\nM V30 BEGIN CTAB\n";n+=`M V30 COUNTS ${e.length} ${e.length?e.length-1:0} 0 0 0\n`,n+="M V30 BEGIN ATOM\n";for(let r=0;r<e.length;r++)n+=s?`M V30 ${r+1} R${t.get(e[r])} 0.000 0.000 0 0\n`:`M V30 ${r+1} At 0.000 0.000 0 0 MASS=${t.get(e[r])}\n`;n+="M V30 END ATOM\n",n+="M V30 BEGIN BOND\n";for(let t=0;t<e.length-1;t++)n+=`M V30 ${t+1} 1 ${t+1} ${t+2}\n`;return n+="M V30 END BOND\n",n+="M V30 END CTAB\n",n+="M END",n}},3348:(e,t,s)=>{"use strict";s.d(t,{_package:()=>rt,activityCliffs:()=>at,getBioLib:()=>ot,getHelmMonomers:()=>ut,getMonomerLibHelper:()=>it,importFasta:()=>ht,sequenceIdentityScoring:()=>dt,sequenceSimilarityScoring:()=>mt,sequenceSpaceTopMenu:()=>lt,toAtomicLevel:()=>ct});var n,r,i=s(4469),o=s(3870),a=s(976),l=s(4628);(r=n||(n={})).EUCLIDEAN="EUCLIDEAN",r.MANHATTAN="MANHATTAN";const c="MCL";a.SEMTYPE.MOLECULE,a.SEMTYPE.MACROMOLECULE;var h=s(442),u=(s(5697),s(701)),d=s(3379),m=s.n(d),p=s(7795),f=s.n(p),g=s(569),y=s.n(g),b=s(3565),w=s.n(b),C=s(9216),v=s.n(C),T=s(4589),A=s.n(T),S=s(9414),_={};_.styleTagTransform=A(),_.setAttributes=w(),_.insert=y().bind(null,"head"),_.domAPI=f(),_.insertStyleElement=v(),m()(S.Z,_),S.Z&&S.Z.locals&&S.Z.locals;const E=e=>null==e;function P(e,t,s,n){if(s>e[e.length-1])return;const r=e.findIndex((e=>s<e));e.pop(),e.splice(r,0,s),t.pop(),t.splice(r,0,n)}class ${_workerCount;constructor(){this._workerCount=Math.max(navigator.hardwareConcurrency-2,1)}async calcMultiColumn(e,t,r,i=[{}],o=[1],a=n.EUCLIDEAN){const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=e[0].length>2e4?await this.getMinimalThreshold(e,t,i,o,a):0;r<h&&(console.log(`using threshold ${h}`),r=h),i.forEach(((e,t)=>i[t].threshold=r));const u=new Array(this._workerCount),d=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(23),s.b))));for(let s=0;s<this._workerCount;s++)u[s]=new Promise(((n,h)=>{const u=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=u&&n({i:new Int32Array(0),j:new Int32Array(0),distance:new Float32Array(0),idx:s}),d[s].postMessage({values:e,startIdx:u,endIdx:m,threshold:r,fnNames:t,opts:i,weights:o,aggregationMethod:a}),d[s].onmessage=({data:{error:e,i:t,j:r,distance:i}})=>{e?(d[s].terminate(),h(e)):(d[s].terminate(),n({i:t,j:r,distance:i,idx:s}))}}));const m=await Promise.all(u),p=m.reduce(((e,t)=>e+t.i.length),0),f=new Int32Array(p),g=new Int32Array(p),y=new Float32Array(p);let b=0;for(const e of m)f.set(e.i,b),g.set(e.j,b),y.set(e.distance,b),b+=e.i.length;return{i:f,j:g,distance:y}}async calc(e,t,s,n={}){return await this.calcMultiColumn([e],[t],s,[n],[1])}async getKNN(e,t,s=15,n={}){return await this.multiColumnKNN([e],[t],s,[n],[1])}async getThresholdKNN(e,t,s=.8,n={}){return await this.multiColumnThresholdKnn([e],[t],s,[n],[1])}async multiColumnThresholdKnn(e,t,r=.8,i,o,a=n.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(427),s.b))));for(let s=0;s<this._workerCount;s++)h[s]=new Promise(((n,h)=>{const d=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=d&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[s].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,threshold:r,weights:o,aggregationMethod:a}),u[s].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[s].terminate(),h(e)):(u[s].terminate(),n({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),m=new Int32Array(e[0].length);for(const t of d)for(let s=0;s<e[0].length;++s)m[s]+=t.knnIndexes[s]?.length??0;const p={knnDistances:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t]))),knnIndexes:new Array(e[0].length).fill(null).map(((e,t)=>new Array(m[t])))};for(const t of d)for(let s=0;s<e[0].length;++s)for(let e=0;e<t.knnDistances[s]?.length;++e)p.knnDistances[s][m[s]-1]=t.knnDistances[s][e],p.knnIndexes[s][m[s]-1]=t.knnIndexes[s][e],m[s]-=1;return p}async multiColumnKNN(e,t,r=15,i,o,a=n.EUCLIDEAN){if(e.length!==t.length||e.length!==i.length||e.length!==o.length)throw new Error("values, distance functions, options and weights arrays should have the same length");if(e.some((t=>t.length!==e[0].length)))throw new Error("all values arrays should have the same length");const l=e[0].length*(e[0].length-1)/2,c=Math.floor(l/this._workerCount),h=new Array(this._workerCount),u=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(282),s.b))));for(let s=0;s<this._workerCount;s++)h[s]=new Promise(((n,h)=>{const d=s*c,m=s===this._workerCount-1?l:(s+1)*c;m<=d&&n({knnDistances:new Array(0),knnIndexes:new Array(0)}),u[s].postMessage({values:e,startIdx:d,endIdx:m,fnNames:t,opts:i,nNeighbours:r,weights:o,aggregationMethod:a}),u[s].onmessage=({data:{error:e,knnDistances:t,knnIndexes:r}})=>{e?(u[s].terminate(),h(e)):(u[s].terminate(),n({knnDistances:t,knnIndexes:r}))}}));const d=await Promise.all(h),m={knnDistances:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(99999))),knnIndexes:new Array(e[0].length).fill(null).map((()=>new Array(r).fill(-1)))};for(const t of d)for(let s=0;s<e[0].length;++s)for(let e=0;e<t.knnDistances[s]?.length;++e)P(m.knnDistances[s],m.knnIndexes[s],t.knnDistances[s][e],t.knnIndexes[s][e]);return m}async getSampleDistances(e,t,r=[],i,o=n.EUCLIDEAN){const a=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(40),s.b))));try{const s=e[0].length*(e[0].length-1)/2,n=Math.floor(s/this._workerCount),l=1e6,c=Math.max(Math.min(s/1e3,l),Math.min(s,l)),h=Math.floor(c/this._workerCount),u=new Array(this._workerCount);for(let l=0;l<this._workerCount;l++)u[l]=new Promise(((c,u)=>{const d=l*n,m=l===this._workerCount-1?s:(l+1)*n;a[l].postMessage({values:e,startIdx:d,endIdx:m,sampleLength:h,fnNames:t,opts:r,weights:i,aggregationMethod:o}),a[l].onmessage=({data:{error:e,distance:t}})=>{a[l].terminate(),e?u(e):c({distance:t})}}));const d=await Promise.all(u),m=d.reduce(((e,t)=>e+t.distance.length),0),p=new Float32Array(m);let f=0;for(const e of d)p.set(e.distance,f),f+=e.distance.length;return p.sort(),p}catch(e){return a?.forEach((e=>e?.terminate())),console.error(e),new Float32Array(1).fill(.5)}}async getMinimalThreshold(e,t,s=[],r,i=n.EUCLIDEAN){try{const n=e.length*(e.length-1)/2,o=await this.getSampleDistances(e,t,s,r,i);return 1-o[Math.floor(7e7/n*o.length)]}catch(e){return console.error(e),.5}}static calcSync(e,t,s,n){const r=[],i=[],o=[];let a=0,l=0,c=0;const h=e.length*(e.length-1)/2;for(;a<h;){const t=E(e[l])||E(e[c])?1:s(e[l],e[c]);1-t>=n&&(r.push(l),i.push(c),o.push(t)),a++,c++,c===e.length&&(l++,c=l+1)}return{i:new Int32Array(r),j:new Int32Array(i),distance:new Float32Array(o)}}}var x,N=s(9657);!function(e){e.none="none",e.bold="bold",e.dashed="dashed"}(x||(x={}));class M{get currentLineId(){return this._currentLineIdx}set currentLineId(e){e!==this._currentLineIdx&&(this._currentLineIdx=e,this.sp.render(this.ctx))}set linesToRender(e){this.updateLines(e),this.sp.render(this.ctx)}set linesVisibility(e){this.visibility=e,this.sp.render(this.ctx)}constructor(e,t,s,n,r=x.none){var i;this._currentLineIdx=-1,this.lineClicked=new u.Subject,this.lineHover=new u.Subject,this.mouseOverLineId=-1,this.arrowWidth=15,this.sp=e,this.xAxisCol=this.sp.dataFrame.columns.byName(t),this.yAxisCol=this.sp.dataFrame.columns.byName(s),this.canvas=this.sp.getInfo().canvas,this.ctx=this.canvas.getContext("2d"),this.currentLineStyle=r,this.updateLines(n),this.visibility=null!==(i=n.visibility)&&void 0!==i?i:new N.Z(this.lines.from.length),n.visibility||this.visibility.setAll(!0,!1),n.arrowSize&&(this.arrowWidth=n.arrowSize),this.canvas.onmousedown=e=>{-1!==this.mouseOverLineId&&this.lineClicked.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},this.canvas.onmousemove=e=>{this.mouseOverLineId=this.checkCoordsOnLine(e.offsetX,e.offsetY),-1!==this.mouseOverLineId&&this.lineHover.next({x:e.clientX,y:e.clientY,id:this.mouseOverLineId,event:e})},e.onEvent("d4-before-draw-scene").subscribe((e=>{this.renderLines()}))}updateLines(e){this.lines=e,this.multipleLinesCounts=new Uint8Array(this.lines.from.length),e.skipMultiLineCalculation?this.multipleLinesCounts.fill(0):this.createMultiLinesIndices()}renderLines(){var e,t,s,n,r,i,o,a,l,c,h,u,d;const m=this.sp.getOptions().look,p=this.lines.colors||this.lines.width||this.lines.opacities||this.lines.drawArrowsArr;p||(this.ctx.lineWidth=null!==(e=this.lines.width)&&void 0!==e?e:1,this.ctx.strokeStyle=`rgba(${null!==(t=this.lines.color)&&void 0!==t?t:"0,128,0"},${null!==(s=this.lines.opacity)&&void 0!==s?s:1})`);const f=m.sizeColumnName?this.sp.dataFrame.col(m.sizeColumnName):null,g=this.sp.dataFrame.filter;for(let e=0;e<this.lines.from.length;e++)if(g.get(this.lines.from[e])&&g.get(this.lines.to[e])&&this.visibility.getBit(e)){let t=0;const{sizeFrom:s,sizeTo:g}=this.getMarkersSizes(m,f,e),y=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[e]),this.yAxisCol.get(this.lines.from[e]));let b=null==y?void 0:y.x,w=null==y?void 0:y.y;const C=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[e]),this.yAxisCol.get(this.lines.to[e]));let v=null==C?void 0:C.x,T=null==C?void 0:C.y;const A=Math.min(this.sp.viewBox.width,this.sp.viewBox.height);if(this.ctx.beginPath(),b&&w&&v&&T&&Math.hypot(v-b,T-w)/A>.01){if(p){const t=(null===(n=this.lines.colors)||void 0===n?void 0:n[e])?null===(r=this.lines.colors)||void 0===r?void 0:r[e]:"0,128,0",s=(null===(i=this.lines.opacities)||void 0===i?void 0:i[e])?null===(o=this.lines.opacities)||void 0===o?void 0:o[e]:1;this.ctx.strokeStyle=`rgba(${t},${s})`,this.ctx.lineWidth=(null===(a=this.lines.widths)||void 0===a?void 0:a[e])?null===(l=this.lines.widths)||void 0===l?void 0:l[e]:1}e===this._currentLineIdx&&this.toggleCurrentLineStyle(!0);const m=this.multipleLinesCounts[e];let f=null;if(m){t=this.getLineLength(b,w,v,T);const n=this.getPointOnDistance(b,w,v,T,g,t),r=this.getPointOnDistance(v,T,b,w,s,t);b=n.x,w=n.y,v=r.x,T=r.y,f=this.lines.from[e]>this.lines.to[e]?this.findControlPoint(m,b,w,v,T,e):this.findControlPoint(m,v,T,b,w,e),this.ctx.moveTo(b,w),this.ctx.quadraticCurveTo(f.x,f.y,v,T)}else this.ctx.moveTo(b,w),this.ctx.lineTo(v,T);if((null!==(c=this.lines.drawArrows)&&void 0!==c?c:null===(h=this.lines.drawArrowsArr)||void 0===h?void 0:h.getBit(e))&&(t||(t=this.getLineLength(b,w,v,T)),t>this.arrowWidth)){const e=m?null:this.getPointOnDistance(b,w,v,T,g,t),s=m?f.x:b,n=m?f.y:w;this.canvasArrow(this.ctx,null!==(u=null==e?void 0:e.x)&&void 0!==u?u:b,null!==(d=null==e?void 0:e.y)&&void 0!==d?d:w,s,n)}this.ctx.stroke(),this.ctx.closePath(),e===this._currentLineIdx&&this.toggleCurrentLineStyle(!1)}}this.fillLeftBottomRect()}toggleCurrentLineStyle(e){switch(this.currentLineStyle){case x.bold:e?this.ctx.lineWidth+=2:this.ctx.lineWidth-=2;break;case x.dashed:e?this.ctx.setLineDash([5,5]):this.ctx.setLineDash([]);break;default:return}}getMarkersSizes(e,t,s){let n=3,r=3;return t?(n=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.from[s]))/2,r=(e.markerMinSize+(e.markerMaxSize-e.markerMinSize)*t.scale(this.lines.to[s]))/2):e.markerDefaultSize&&(n=e.markerDefaultSize/2,r=e.markerDefaultSize/2),{sizeFrom:n,sizeTo:r}}fillLeftBottomRect(){const e=new Path2D;e.rect(this.sp.yAxisBox.minX,this.sp.yAxisBox.maxY,this.sp.yAxisBox.width,this.sp.xAxisBox.height),this.ctx.fillStyle="white",this.ctx.beginPath(),this.ctx.fill(e),this.ctx.closePath()}createMultiLinesIndices(){const e=new N.Z(this.lines.from.length);e.setAll(!0);for(let t=-1;-1!==(t=e.findNext(t));){const s=t,n=this.lines.from[s],r=this.lines.to[s];let i=1;for(let s=t;-1!==(s=e.findNext(s));){const t=this.lines.from[s],o=this.lines.to[s];(t===n&&o===r||o===n&&t===r)&&(this.multipleLinesCounts[s]=++i,e.setBit(s,!1,!1))}i>1&&(this.multipleLinesCounts[s]=1),e.setBit(t,!1,!1)}}checkCoordsOnLine(e,t){let s=-1,n=null,r=null;const i=this.sp.getOptions().look,o=i.sizeColumnName?this.sp.dataFrame.col(i.sizeColumnName):null,a=this.sp.dataFrame.filter;for(let l=0;l<this.lines.from.length;l++)if(a.get(this.lines.from[l])&&a.get(this.lines.to[l])&&this.visibility.getBit(l)){const{sizeFrom:a,sizeTo:c}=this.getMarkersSizes(i,o,l),h=this.sp.worldToScreen(this.xAxisCol.get(this.lines.from[l]),this.yAxisCol.get(this.lines.from[l])),u=this.sp.worldToScreen(this.xAxisCol.get(this.lines.to[l]),this.yAxisCol.get(this.lines.to[l]));if(this.multipleLinesCounts[l]){const s=this.getLineLength(h.x,h.y,u.x,u.y),n=this.getPointOnDistance(h.x,h.y,u.x,u.y,c,s),i=this.getPointOnDistance(u.x,u.y,null==h?void 0:h.x,null==h?void 0:h.y,a,s),o=this.lines.from[l]>this.lines.to[l]?this.findControlPoint(this.multipleLinesCounts[l],n.x,n.y,i.x,i.y,l):this.findControlPoint(this.multipleLinesCounts[l],i.x,i.y,n.x,n.y,l);r=this.calculateDistToCurveLine(l,e,t,n,i,o)}else r=this.calculateDistToStraightLine(e,t,h,u);(!n&&null!==r&&r<5||n&&null!==r&&r<n)&&(n=r,s=l)}return s}calculateDistToStraightLine(e,t,s,n){const r=Math.min(s.x,n.x),i=Math.max(s.x,n.x),o=Math.min(s.y,n.y),a=Math.max(s.y,n.y);return e>=r-2&&e<=i+2&&t>=o-2&&t<=a+2?this.distToStraightLineSegment(e,t,s,n):null}distToStraightLineSegment(e,t,s,n){const r=(e,t,s,n)=>Math.pow(e-s,2)+Math.pow(t-n,2),i=r(s.x,s.y,n.x,n.y);if(0==i)return r(e,t,s.x,s.y);let o=((e-s.x)*(n.x-s.x)+(t-s.y)*(n.y-s.y))/i;return o=Math.max(0,Math.min(1,o)),r(e,t,s.x+o*(n.x-s.x),s.y+o*(n.y-s.y))}calculateDistToCurveLine(e,t,s,n,r,i){const o=Math.min(n.x,r.x,i.x),a=Math.max(n.x,r.x,i.x),l=Math.min(n.y,r.y,i.y),c=Math.max(n.y,r.y,i.y);if(t>=o-2&&t<=a+2&&s>=l-2&&s<=c+2){const e=a-o,h=c-l;return this.calculateDistToCurveInRect(t,s,n,i,r,e,h)}return null}calculateDistToCurveInRect(e,t,s,n,r,i,o){const a=Math.floor((i+o)/3),l=1/a,c=new Uint32Array(a),h=new Uint32Array(a),u=new Uint32Array(a);let d=null;const m=new N.Z(a);for(let i=0;i<c.length;i++){const o=i*l,a=Math.pow(1-o,2)*s.x+2*o*(1-o)*n.x+Math.pow(o,2)*r.x,m=Math.pow(1-o,2)*s.y+2*o*(1-o)*n.y+Math.pow(o,2)*r.y,p=Math.abs(e-a),f=Math.abs(t-m),g=p+f;(!d||d>g)&&(d=g),u[i]=Math.max(p,f),c[i]=a,h[i]=m}for(let e=0;e<c.length;e++)u[e]<d&&m.setBit(e,!0,!1);let p=null;for(let s=-1;-1!==(s=m.findNext(s));){const n=Math.hypot(c[s]-e,h[s]-t);(!p||p>n)&&(p=n)}return p}getLineLength(e,t,s,n){return Math.sqrt(Math.pow(s-e,2)+Math.pow(n-t,2))}getPointOnDistance(e,t,s,n,r,i){const o=s-r*((s-e)/i),l=n-r*((n-t)/i);return new a.Point(o,l)}findControlPoint(e,t,s,n,r,i){const o=t+(n-t)/2,l=s+(r-s)/2;let c=o-t,h=l-s;const u=Math.sqrt(c*c+h*h);c/=u,h/=u;const d=50*Math.ceil(e/2);return e%2==0?new a.Point(o+d/2*h,l-d/2*c):new a.Point(o-d/2*h,l+d/2*c)}canvasArrow(e,t,s,n,r){const i=Math.atan2(n-t,r-s)+Math.PI;e.moveTo(t-this.arrowWidth*Math.sin(i-Math.PI/10),s-this.arrowWidth*Math.cos(i-Math.PI/10)),e.lineTo(t,s),e.lineTo(t-this.arrowWidth*Math.sin(i+Math.PI/10),s-this.arrowWidth*Math.cos(i+Math.PI/10))}}const L="dimensionality-reducer-terminate-event";var I=s(850);async function R(e,t,n,r,o,a,l){let c=await async function(e,t,n,r,o,a,l){if(!a.distanceFnArgs)throw new Error("options.distanceFnArgs must be defined");if(e.length!==t.length||e.length!==a.distanceFnArgs.length||e.length!==r.length)throw new Error("data, metrics and options and weights must have the same length");return new Promise((function(c,h){const u=new Worker(new URL(s.p+s.u(42),s.b));u.postMessage({columnsData:e,distanceMetrics:t,method:n,options:a,weights:r,aggregationMethod:o});const d=i.events.onCustomEvent(L).subscribe((()=>{try{u?.terminate()}finally{d.unsubscribe()}}));u.onmessage=({data:{error:e,embedding:t,epochNum:s,epochsLength:n}})=>{E(s)||E(n)?(d.unsubscribe(),e?h(e):c(t),setTimeout((()=>u.terminate()),100)):l&&l(s,n,t)}}))}(e,n,t,r,o,a,l);return c=c.map((e=>(0,I.Fv)(e))),c}let O=0;const k="cliffsDf",F=new u.Subject,D="activity_difference",G="SALI_index",H="similarity",W="line_index",B=["1_molecule","2_molecule"],V="filterCliffs";var U,j=s(499),Y=s(5226),K=s(7228),q=s(8457),Z=s(8260);async function z(e,t,s,n){const r=(0,q.O)(t),i=(0,Z.vU)(t.getTag(a.TAGS.UNITS),t.getTag("separator"))(s),o=n===U.IDENTITY?function(e,t){const s=t.columns.length,n=new Array(s),r=new Array(s),i=new Array(s);for(let o=0;o<s;++o){const s=t.columns.byIndex(o);n[o]=s.getRawData(),r[o]=s.categories.indexOf(""),i[o]=s.categories.indexOf(e[o]??"")}const o=a.Column.float("Identity",t.rowCount),l=o.getRawData();for(let s=0;s<t.rowCount;++s){l[s]=0;for(let t=0;t<e.length;++t)n[t][s]===i[t]&&++l[s];l[s]/=e.length}return o}(i,r):n===U.SIMILARITY?await async function(e,t){const s=t.columns.toList();return await(0,K.Qx)(s,e)}(i,r):null;if(null===o)throw new Error(`In bio library: Unkown sequence scoring method: ${n}`);return o.name=e.columns.getUnusedName(o.name),e.columns.add(o),o}!function(e){e.IDENTITY="identity",e.SIMILARITY="similarity"}(U||(U={}));var X=s(7945),J=(s(4293),s(6414)),Q=s.n(J);const ee="rgb(100,100,100)",te="#808080",se="rgb(0,0,0)",ne=Z.GU;var re,ie;function oe(e,t,s,n,r,i,o=ee,a=0,l=!1,c=1,h="",u=!1,d=ie.classic,m=[],p=0,f=null,g=[],y=null,b={}){r.textAlign="start";let w=i.substring(0),C=u?"":h;d===ie.MSA&&(C="");let v=!0,T=!0,A="difference";null!=f&&null!=f.cell.column&&(v=f.cell.column.temp["color-code"]??!0,T=f.cell.column.temp["compare-with-current"]??!0,A=f.cell.column.temp["highlight-difference"]??"difference");const S=g[p];T&&g.length>0&&"difference"===A&&(c=w==S?.3:c),T&&g.length>0&&"equal"===A&&(c=w!=S?.3:c),null!=y&&(w=ne(w,y));const _=w+C;b[_]??(b[_]=r.measureText(_));let E=b[_];b[w]??(b[w]=r.measureText(w));let P=b[w].width;b[C]??(b[C]=r.measureText(C));const $=b[C].width,x=n/2-(E.fontBoundingBoxAscent+E.fontBoundingBoxDescent)/2+1;function N(s,n){const i=v?o:se;r.fillStyle=i,r.globalAlpha=c,d===ie.classic&&(r.fillText(w,e+s,t+x),r.fillStyle=te,r.fillText(C,e+n,t+x)),d===ie.MSA&&r.fillText(w,e+s,t+x)}E=E.width,d===ie.MSA&&(P=m[p],E=m[p]);const M=(m[p]??0)-(m[0]??0);if(l||E>s)return N(M,M+P),e+M+P+$;{const t=(s-E)/2;return N(t,t+P),e+M+t+P}}!function(e){e.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(re||(re={})),function(e){e.MSA="MSA",e.classic="classic"}(ie||(ie={})),s(9611);var ae,le,ce=s(8447),he=s(7331);function ue(e){const t=!Q().enumerate(e).some((([t,s])=>t.length>1&&0!=s&&s!=e.length-1)),s=[],n=t?"":" ";for(const[t,r]of Q().enumerate(e)){let i=t;r<e.length&&(i+=`${t?"":"-"}${n}`),s.push(i)}return[s,t]}(le=ae||(ae={})).long="long",le.short="short",s(3553),ce.GU;class de extends a.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(e,t){e.cell.column.temp["current-word"]=e.cell.value,e.grid.invalidate()}onMouseMove(e,t){const s=e.cell.column.temp["bio-seqCol"];if(!s)return;const n=e.bounds,r=t.offsetX-e.gridColumn.left+(e.gridColumn.left-n.x),a=s.getPosition(e.tableRowIndex,r),l=s.getSeqMonList(e.tableRowIndex);if(null!==a&&a<l.length){const e=l[a],n=[o.div(e)];if(s._monomerStructureMap[e])n.push(s._monomerStructureMap[e]);else{const t=s.getMonomer(e);if(t){const r={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=i.chem.svgMol(t.smiles,void 0,void 0,r);n.push(o),s._monomerStructureMap[e]=o}}o.tooltip.show(o.divV(n),t.x+16,t.y+16)}else o.tooltip.hide()}render(e,t,s,n,r,i,o){try{i.grid}catch(e){const[t,s]=(0,X.yf)(e);rt.logger.error(t,void 0,s)}i.cell.column}}class me extends a.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return constants.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(e,t,s,n,r,i,o){const l=window.devicePixelRatio,c=i.grid,h=i.cell,u=i.tableColumn,d=h.value??"",m=u.tags.separator,p=u.tags[a.TAGS.UNITS];getUpdatedWidth(c,e,t,n,l);const[f,g]=d.split("#"),y=(0,Z.vU)(p,m);pe(e,t,s,n,r,y(f),y(g),p)}}function pe(e,t,s,n,r,i,o,a,l,c){if(i.length!==o.length){const e=function(e,t){let s=0,n=0;const r=e.length>t.length?e:t,i=e.length>t.length?t:e;for(let e=0;e<i.length;e++)r[e]===i[e]&&s++;const o=r.length-i.length;for(let e=r.length-1;e>o;e--)r[e]===i[e-o]&&n++;const a=new Array(Math.abs(e.length-t.length)).fill("");function l(e){return s>n?e.concat(a):a.concat(e)}return e.length>t.length?t=l(t):e=l(e),{subParts1:e,subParts2:t}}(Q()(i).toArray(),Q()(o).toArray());i=e.subParts1,o=e.subParts2}const h=e.measureText(ue(i).join("")),u=e.measureText(ue(o).join("")),d=Math.max(h.width,u.width);l&&(n=d+4*i.length,e.canvas.width=d+4*i.length);let m=Math.max(t,t+(n-(d+4*i.length))/2)+5;const p=Math.max(s,s+(r-28)/2);e.save(),e.beginPath(),e.rect(t,s,l?d+4*i.length:n,r),e.clip(),e.font="12px monospace",e.textBaseline="top";let f=he.UE.Color;"HELM"!=a&&(f=(0,ce.py)(a.substring(a.length-2)));for(let t=0;t<i.length;t++){const s=i[t],a=o[t],l=f.get(s);if(s!=a){const i=f.get(a),o=oe(m,p-7,n,r,e,s,l,0,!0),h=oe(m,p+7,n,r,e,a,i,0,!0);m=Math.max(h,o),c&&(c[t]=fe(s,a,l,i,p,7,r))}else m=oe(m,p,n,r,e,s,l,0,!0,.5);m+=4}e.restore()}function fe(e,t,s,n,r,i,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const c=l.measureText(ue([e]).join("")).width,h=l.measureText(ue([t]).join("")).width,u=Math.max(c,h);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",oe(0,r-i,u,o,l,e,s,0,!0),oe(0,r+i,u,o,l,t,n,0,!0),a}var ge,ye=s(8467),be=s(9298);!function(e){e.Unknown="unknown",e.FR="framework",e.CDR="cdr"}(ge||(ge={}));const we=new class{constructor(){this.regionTypes=[ge.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=be.ES.Entropy,this.filterSource=be.vS.filterSource}};var Ce=s(172),ve=s(8415);const Te=ge;var Ae,Se;!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(Ae||(Ae={})),function(e){e.skipEmptyPositions="skipEmptyPositions",e.regionTypes="regionTypes",e.chains="chains",e.fitWidth="fitWidth",e.positionWidth="positionWidth",e.positionHeight="positionHeight",e.filterSource="filterSource"}(Se||(Se={}));const _e=we;class Ee extends a.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewerId=++Ee.viewerCounter,this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this._onRendered=new u.Subject,this.skipEmptyPositions=this.bool(Se.skipEmptyPositions,_e.skipEmptyPositions,{category:Ae.DATA}),this.regionTypes=this.stringList(Se.regionTypes,_e.regionTypes,{category:Ae.DATA,choices:Object.values(Te).filter((e=>e!=Te.Unknown))}),this.chains=this.stringList(Se.chains,_e.chains,{category:Ae.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(Se.fitWidth,_e.fitWidth,{category:Ae.LAYOUT}),this.positionWidth=this.float(Se.positionWidth,_e.positionWidth,{category:Ae.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(Se.positionHeight,_e.positionHeight,{category:Ae.LAYOUT,choices:Object.keys(be.ES)}),this.filterSource=this.string(Se.filterSource,_e.filterSource,{category:Ae.BEHAVIOR,choices:Object.values(be.Ct)}),this.viewSyncer=new Ce.c(rt.logger)}viewerToLog(){return`VdRegionsViewer<${this.viewerId}>`}async init(){this.subs.push((0,u.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const e=`${this.viewerToLog()}.detach()`,t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(e){if(super.onPropertyChanged(e),e){switch(e.name){case Se.regionTypes:case Se.chains:this.setData(this.regions)}switch(e.name){case Se.skipEmptyPositions:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case Se.fitWidth:case Se.positionWidth:this.calcSize();break;case Se.positionHeight:for(let e=0;e<this.logos.length;++e)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.positionHeight]:this.positionHeight});this.calcSize();break;case Se.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(e){const t=`${this.viewerToLog()}.setData()`;rt.logger.debug(`${t}, in, regions.length = ${e.length}`),this.viewSyncer.sync(`${t}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),this.regions=e,this.viewed||(await this.buildView("setData"),this.viewed=!0)}finally{this.setDataInProgress=!1}}}))}async destroyView(e){rt.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${e}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&o.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const e of this.viewSubs)e.unsubscribe()}async buildView(e){rt.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${e}', this.regions.length = ${this.regions.length}`);const t=this.regions.filter((e=>this.regionTypes.includes(e.type))),s=Array.from(new Set(t.map((e=>e.order)))).sort(),n=[];for(let e=0;e<s.length;e++)for(const r of this.chains){const i=t.find((t=>t.order==s[e]&&t.chain==r));n.push((async()=>{const t=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:i.sequenceColumnName,startPositionName:i.positionStartName,endPositionName:i.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return t.onSizeChanged.subscribe((()=>{this.calcSize()})),[e,r,t]})())}const r=await Promise.all(n);this.logos=new Array(s.length);for(let e=0;e<s.length;++e)this.logos[e]={};for(const[e,t,s]of r)this.logos[e][t]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=o.table(this.chains,(e=>[...s.length>0?[o.div(e,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((t=>{const s=this.logos[t][e];return s.root.style.height="100%",o.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((e=>t.find((t=>t.order==s[e]&&t.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=o.choiceInput("Data source",this.filterSource,Object.values(be.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=o.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(o.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),rt.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){rt.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const e=()=>{if(!this.host)return;const e=(this.root.clientHeight-54)/this.chains.length;let t=0;for(let s=0;s<this.logos.length;s++){for(const t of this.chains)this.logos[s][t].root.style.height=`${e}px`;t+=Math.max(...this.chains.map((e=>this.logos[s][e].Length)))}if(this.fitWidth){if(this.logos.length>0&&t>0){const e=22,s=13,n=9,r=(this.root.clientWidth-e-(this.logos.length-1)*n-s)/t;for(let e=0;e<this.logos.length;e++)for(const t of this.chains){const s=this.logos[e][t];s.setOptions({[ve.bo.positionWidth]:r-s.positionMarginValue}),s.root.style.width=r*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let e=0;e<this.logos.length;e++)for(const t of this.chains)this.logos[e][t].setOptions({[ve.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{e(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(e){this.calcSize()}rootOnMouseMove(e){}filterSourceInputOnValueChanged(){const e=`${this.viewerToLog()}.filterSourceInputOnValueChanged()`,t=this.filterSourceInput.value;this.viewSyncer.sync(`${e}`,(async()=>{if(this.filterSource!==t){this.props.getProperty(Se.filterSource).set(this,t);for(let e=0;e<this.logos.length;e++)for(let t=0;t<this.chains.length;t++){const s=this.chains[t];this.logos[e][s].setOptions({[ve.bo.filterSource]:this.filterSource})}}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.viewerToLog()}.invalidate(${e?` <- ${e} `:""})`;this.viewSyncer.sync(`${t}`,(async()=>{this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,ye.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function Pe(e){const t=o.divH([],{style:{gap:"10px"}}),s=o.divV([o.divText(e.seqCol.name),o.divText(e.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",t.append(s),e.points.forEach((s=>{const n=o.divText(e.activityCol.get(s).toFixed(2));n.style.display="flex",n.style.justifyContent="left",n.style.paddingLeft="30px",t.append(o.divV([o.divText(e.seqCol.get(s)),n]))})),t}function $e(e){const t=o.div();t.append(o.divText(e.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);e.points.forEach(((t,r)=>{s[r]=e.seqCol.get(t),n[r]=e.activityCol.get(t)}));const r={},i=j.Cn.getOrCreate(e.seqCol),a=i.getSplitter(),l=function(e,t,s,n){const r=document.createElement("canvas"),i=r.getContext("2d");return r.height=30,pe(i,0,0,0,30,e,t,s,!0,n),r}(a(s[0]),a(s[1]),i.units,r);return t.append(o.div(l,{style:{width:"300px",overflow:"scroll"}})),t.append(function(e){const t=o.div();if(Object.keys(e).length>0){const s=o.divV([]);s.append(o.divH([o.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),o.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const t of Object.keys(e))e[t].style.borderBottom="1px solid lightgray",s.append(o.divH([o.divText((parseInt(t)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),e[t]]));t.append(s)}return t}(r)),t.append(xe("Activity delta",Math.abs(n[0]-n[1]))),t.append(xe("Cliff",e.sali)),t}function xe(e,t){return o.divH([o.divText(`${e}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),o.divText(t.toFixed(2))],{style:{paddingTop:"10px"}})}function Ne(e,t){const s=a.Column.string("seq_diff",e.rowCount).init((s=>`${e.get(t[0],s)}#${e.get(t[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(a.TAGS.UNITS,e.col(t[0]).getTag(a.TAGS.UNITS)),s.setTag("separator",e.col(t[0]).getTag("separator")),e.columns.add(s);const n=e.plot.grid();return n.col(t[0]).visible=!1,n.col(t[1]).visible=!1,n}Ee.viewerCounter=-1,s(708),s(6361),s(7983);class Me extends a.JsViewer{constructor(e){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[a.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",distance_metrics_methods.kg[0],{choices:distance_metrics_methods.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=e}init(){this.initialized=!0}detach(){this.subs.forEach((e=>e.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(a.debounce(this.dataFrame.onRowsRemoved,50).subscribe((e=>this.render(!0))));const e="diversity"!==this.name;this.subs.push(a.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((t=>this.render(e)))),this.subs.push(a.debounce(this.dataFrame.selection.onChanged,50).subscribe((e=>this.render(!1)))),this.subs.push(a.debounce(o.onSizeChanged(this.root),50).subscribe((e=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(a.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(e){if(super.onPropertyChanged(e),this.initialized){if("moleculeColumnName"===e.name){const t=this.dataFrame.col(e.get(this));t.semType===a.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=t)}this.render()}}render(e=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||e,await this.renderInt(e)}))}async renderInt(e){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==a.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}s(7241),s(4004),s(9943),s(5393);var Le=s(7572),Ie=(s(3336),s(8710)),Re={};Re.styleTagTransform=A(),Re.setAttributes=w(),Re.insert=y().bind(null,"head"),Re.domAPI=f(),Re.insertStyleElement=v(),m()(Ie.Z,Re),Ie.Z&&Ie.Z.locals&&Ie.Z.locals,s(6584),s(3776),s(2428);var Oe,ke=function(e,t,s,n){return new(s||(s=Promise))((function(r,i){function o(e){try{l(n.next(e))}catch(e){i(e)}}function a(e){try{l(n.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof s?t:new s((function(e){e(t)}))).then(o,a)}l((n=n.apply(e,t||[])).next())}))};class Fe{constructor(e,t,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._stopStartBtn=o.button(o.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=o.button(o.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=o.button(o.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._closeBtn=o.button(o.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=e,this.description=t,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,Fe.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=o.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var e;this._activity.append(o.div(this.description,"tutorials-root-description"));for(let t=0;t<this.stepNumber;t++){let s=o.iconFA("clock");this._isAutomatic||0===t&&(s=o.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=o.div(this._steps[t].name,"grok-tutorial-entry-instruction"),r=o.div(null===(e=this._steps[t].options)||void 0===e?void 0:e.description,"grok-tutorial-step-description hidden"),i=o.divH([s,n],"grok-tutorial-entry");this._activity.append(i,r)}}_initRoot(){var e,t,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,a.DOCK_TYPE.FILL,n,""),(null===(t=null===(e=n.parent.container.containerElement.firstElementChild)||void 0===e?void 0:e.lastElementChild)||void 0===t?void 0:t.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var e,t;return ke(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const i=s,a=(null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay)?null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,i.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,n,a),yield(0,ye.gw)(a));const l=o.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const e=this._activity.getElementsByClassName("grok-icon")[this._currentStep],t=o.iconFA("play",(()=>this._nextStep()),"Next step");t.className="grok-icon fas fa-play",e.replaceWith(t),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return ke(this,void 0,void 0,(function*(){for(let e=this._currentStep;e<this.stepNumber&&!this._isStopped&&!this._isCancelled;e++)yield this._nextStep()}))}_scrollTo(e,t){e.focus(),e.scrollTop=t}_countdown(e,t,s){return ke(this,void 0,void 0,(function*(){const n=o.div([],"demo-script-countdown");t.classList.add("hidden");let r=s/1e3;const i=this._createSVGIndicator(r);n.append(i),e.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),t.classList.remove("hidden"),t.classList.add("visible"))}),1e3)}))}_createSVGIndicator(e){const t=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${e}s linear infinite forwards`),t.append(s),t}_changeStopState(){const e=this._stopStartBtn.getElementsByClassName("grok-icon");e[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(e[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=o.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=o.panel([],"tutorials-main-header"),this._header=o.h2(""),this._headerDiv=o.divH([],"tutorials-root-header"),this._activity=o.panel([],"tutorials-root-description"),this._progressDiv=o.divV([],"tutorials-root-progress"),this._progress=o.element("progress"),this._progressSteps=o.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,Fe.currentObject=null}step(e,t,s){return this._steps[this.steps.length]={name:e,func:t,options:s},this}start(){return ke(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}Fe.currentObject=null,function(e){e.X="Embed_X",e.Y="Embed_Y"}(Oe||(Oe={}));var De=function(e,t,s,n){return new(s||(s=Promise))((function(r,i){function o(e){try{l(n.next(e))}catch(e){i(e)}}function a(e){try{l(n.throw(e))}catch(e){i(e)}}function l(e){var t;e.done?r(e.value):(t=e.value,t instanceof s?t:new s((function(e){e(t)}))).then(o,a)}l((n=n.apply(e,t||[])).next())}))};s(7905),s(8341);var Ge=s(2568);s(525),s(9416),new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}};class He extends a.GridCellRenderer{get name(){return constants.Of.MONOMER}get cellType(){return constants.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(e,t,s,n,r,i,o){if(i.gridRow<0)return;MonomerTooltipHandler.getOrCreate(i.gridColumn),e.font="12px monospace",e.textBaseline="middle",e.textAlign="center";const a=(0,ce.py)(i.cell.column.getTag("alphabet")),l=i.cell.value;if(!l)return;const c=a.get(l);e.fillStyle=c,e.fillText((0,ce.GU)(l,6),t+n/2,s+r/2,n)}}class We extends a.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(e){this._properties=e}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(e){const[t,s]=(0,X.yf)(e);i.shell.error(t),this.logger.error(t,void 0,s)}}s(8770);class Be extends a.Widget{constructor(e){super(o.divV([])),this.viewed=!1,this.seqCol=e}async init(){const e=j.Cn.getOrCreate(this.seqCol),t=rt.properties.TooltipWebLogo,s=this.seqCol.getTag(be.DX.tooltipWebLogo);!1===t||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:e.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}detach(){this.wlViewer.detach(),super.detach()}}var Ve=s(922);class Ue{constructor(e,t){this.helmColumn=e,this.df=t,this.helmColumn=e}async convertToSmiles(){const e=await this.getSmilesList(),t=this.df.columns.getUnusedName(`smiles(${this.helmColumn.name})`);return a.Column.fromStrings(t,e.map((e=>null===e?"":e)))}async getSmilesList(){return(await this.convertToMolfileV2KColumn()).toList().map((e=>a.chem.convert(e,a.chem.Notation.MolBlock,a.chem.Notation.Smiles)))}async convertToRdKitBeautifiedMolfileColumn(){const e=await this.getSmilesList(),t=await i.functions.call("Chem:getRdKitModule"),s=e.map((e=>{if(""===e)return null;const s=t.get_mol(e);return s?(s.normalize_depiction(1),s.straighten_depiction(!0),s):null})),n=this.df.columns.getUnusedName(`molfile(${this.helmColumn.name})`);return a.Column.fromStrings(n,s.map((e=>{if(null===e)return"";const t=e.get_v3Kmolblock();return e.delete(),t})))}async convertToMolfileV2KColumn(){const e=(await this.getPolymerGraphColumn()).toList().map(((e,t)=>{const s=this.helmColumn.get(t);if(!s)return"";let n="";try{n=this.getPolymerMolfile(s,e)}catch(e){const[t,s]=(0,X.yf)(e);rt.logger.error(t,void 0,s)}finally{return n}})),t=this.df.columns.getUnusedName(`molfileV2K(${this.helmColumn.name})`);return a.Column.fromList("string",t,e)}async getPolymerGraphColumn(){return await i.functions.call("HELM:getMolfiles",{col:this.helmColumn})}getPolymerMolfile(e,t){const s=new je(t),n=new et(e);return s.monomerSymbols.forEach(((e,t)=>{const r=s.getMonomerShifts(t);n.addMonomer(e,t,r)})),n.compileToMolfile()}}class je{constructor(e){this.molfileHandler=Ve._.getInstance(e)}get monomerSymbols(){return this.molfileHandler.atomTypes}getMonomerShifts(e){return{x:this.molfileHandler.x[e],y:this.molfileHandler.y[e]}}}class Ye{constructor(e,t){this.capGroupElements=[];const s=Le.A.instance.getBioLib().getMonomer(t,e);if(!s)throw new Error(`Monomer ${e} is not found in the library`);this.molfileWrapper=new ze(s.molfile,e),this.capGroupElements=s.rgroups.map((e=>(e.capGroupSMILES||e.capGroupSMILES).replace(/(\[|\]|\*|:|\d)/g,"")))}shiftCoordinates(e){this.molfileWrapper.shiftCoordinates(e)}getAtomLines(){return this.molfileWrapper.getAtomLines()}getBondLines(){return this.molfileWrapper.getBondLines()}removeBondedRGroups(e){this.molfileWrapper.removeRGroups(e)}capTrailingRGroups(){this.molfileWrapper.capRGroups(this.capGroupElements)}replaceRGroupWithAttachmentAtom(e,t){this.molfileWrapper.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.molfileWrapper.getAttachmentAtomByRGroupId(e)}deleteBondLineWithSpecifiedRGroup(e){this.molfileWrapper.deleteBondLineWithSpecifiedRGroup(e)}shiftBonds(e){this.molfileWrapper.shiftBonds(e)}}class Ke{constructor(e,t,s){this.atoms=t,this.bonds=s,this.rGroupBondPositionMap=new Map,this.rGroupIdToAtomicIndexMap=this.getRGroupIdToAtomicIdxMap(e)}getAtomicIdx(e){const t=this.rGroupIdToAtomicIndexMap.get(e);return void 0===t?null:t}removeRGroupsFromAtomBlock(e){e.forEach((e=>{if(void 0===this.rGroupIdToAtomicIndexMap.get(e))throw new Error(`Cannot find atomic index for R group ${e}`)}));const t=Array.from(this.rGroupIdToAtomicIndexMap.entries()).filter((([t,s])=>e.includes(t))).map((([e,t])=>t));this.atoms.deleteAtoms(t)}removeRGroups(e){this.removeRGroupsFromAtomBlock(e),e.forEach((e=>{const t=this.replaceRGroupInBondsByDummy(e);this.rGroupBondPositionMap.set(e,t)}))}replaceRGroupInBondsByDummy(e){const t=this.rGroupIdToAtomicIndexMap.get(e);if(this.rGroupBondPositionMap.has(e))throw new Error(`R group ${e} is already handled`);const s=this.bonds.getPositionsInBonds(t+1);if(0===s.length)throw new Error(`Cannot find position for R group ${e}`);if(s.length>1)throw new Error(`More than one position for R group ${e}`);const n=s[0];return this.bonds.replacePositionsInBondsByDummy([n]),this.bonds.removeAtomIdFromBonds(t+1),this.removeRGroupFromAtomicIdxMap(e,t),n}removeRGroupFromAtomicIdxMap(e,t){this.rGroupIdToAtomicIndexMap.delete(e);for(const[e,s]of this.rGroupIdToAtomicIndexMap)s>t&&this.rGroupIdToAtomicIndexMap.set(e,s-1)}getRGroupIdToAtomicIdxMap(e){const t=new Map;e.filter((e=>e.startsWith("M RGP"))).forEach((e=>{const s=function(e){const t=e.split(/\s+/).filter((e=>e)).slice(3).map((e=>parseInt(e))),s=new Array(t.length/2);for(let e=0;e<t.length;e+=2)s[e/2]=[t[e+1],t[e]-1];return s}(e);for(const[e,n]of s){if(t.has(e))throw new Error(`R group ${e} is already in the map`);t.set(e,n)}}));const s=e.map(((e,t)=>{if(e.startsWith("A "))return t})).filter((e=>void 0!==e)),n=s.map((t=>e[t])),r=s.map((t=>e[t+1]));n.forEach(((e,s)=>{const n=parseInt(e.split(/\s+/)[1])-1,i=parseInt(r[s].substring(1));if(t.has(i))throw new Error(`R group ${i} is already in the map`);t.set(i,n)}));const i=this.atoms.getRGroupAtomicIndices().filter((e=>!Array.from(t.values()).includes(e)));if(0!==i.length)throw new Error(`Unaccounted R group indices: ${i}`);return t}deleteBondLineWithSpecifiedRGroup(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s}=t;this.bonds.deleteBondLines([s]),this.rGroupBondPositionMap.delete(e),this.rGroupIdToAtomicIndexMap.delete(e),this.rGroupBondPositionMap.forEach((e=>{e.bondLineIdx>s&&(e.bondLineIdx-=1)}))}replaceRGroupWithAttachmentAtom(e,t){const s=this.rGroupBondPositionMap.get(e);if(!s)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:n,nodeIdx:r}=s;this.bonds.bondedAtoms[n][r]=t}getAttachmentAtomIdByRGroupId(e){const t=this.rGroupBondPositionMap.get(e);if(!t)throw new Error(`Cannot find position for R group ${e}`);const{bondLineIdx:s,nodeIdx:n}=t;return this.bonds.bondedAtoms[s][(n+1)%2]}capRGroups(e){this.rGroupIdToAtomicIndexMap.forEach(((t,s)=>{const n=e[s-1];"H"===n?(this.removeRGroups([s]),this.deleteBondLineWithSpecifiedRGroup(s)):this.atoms.replaceElementSymbol(t,n)}))}}class qe{constructor(e){this.bondedPairs=[],this.rawBondLines=[],this.rawBondLines=e,this.bondedPairs=this.rawBondLines.map((e=>[parseInt(e.substring(0,3)),parseInt(e.substring(3,6))]))}getBondLines(){return this.bondedPairs.map(((e,t)=>{if(e.some((e=>-1===e)))throw new Error(`Bonded pair ${e} contains -1`);return`${e[0].toString().padStart(3," ")}${e[1].toString().padStart(3," ")}${this.rawBondLines[t].substring(6)}`}))}get bondedAtoms(){return this.bondedPairs}deleteBondLines(e){this.rawBondLines=this.rawBondLines.filter(((t,s)=>!e.includes(s))),this.bondedPairs=this.bondedPairs.filter(((t,s)=>!e.includes(s)))}getPositionsInBonds(e){const t=[];return this.bondedPairs.forEach(((s,n)=>{s.forEach(((s,r)=>{s===e&&t.push({bondLineIdx:n,nodeIdx:r})}))})),t}replacePositionsInBondsByDummy(e,t){void 0===t&&(t=-1),e.forEach((e=>{const{bondLineIdx:s,nodeIdx:n}=e;this.bondedPairs[s][n]=t}))}removeAtomIdFromBonds(e){this.bondedPairs=this.bondedPairs.map((t=>t.map((t=>t>e?t-1:t))))}shift(e){this.bondedPairs=this.bondedPairs.map((t=>t.map((t=>t+e))))}}class Ze{constructor(e){this.coordinates=[],this.rawAtomLines=[],this.rawAtomLines=e,this.coordinates=this.rawAtomLines.map((e=>({x:parseFloat(e.substring(0,10)),y:parseFloat(e.substring(10,20))})))}get atomCoordinates(){return this.coordinates}get atomLines(){return this.rawAtomLines.map(((e,t)=>{const s=this.coordinates[t];return`${s.x.toFixed(4).padStart(10," ")}${s.y.toFixed(4).padStart(10," ")}${e.substring(20)}`}))}replaceElementSymbol(e,t){this.rawAtomLines[e]=this.rawAtomLines[e].replace("R#",t)}deleteAtoms(e){this.coordinates=this.coordinates.filter(((t,s)=>!e.includes(s))),this.rawAtomLines=this.rawAtomLines.filter(((t,s)=>!e.includes(s)))}shift(e){this.coordinates=this.coordinates.map((t=>{const s=t.x+e.x,n=t.y+e.y;if(isNaN(s)||isNaN(n))throw new Error(`Cannot shift coordinates by ${e.x}, ${e.y}`);return{x:s,y:n}}))}rotate(e){this.coordinates=this.coordinates.map((t=>{const s=t.x,n=t.y,r=s*Math.cos(e)-n*Math.sin(e),i=s*Math.sin(e)+n*Math.cos(e);if(isNaN(r)||isNaN(i))throw new Error(`Cannot rotate coordinates by ${e}`);return{x:r,y:i}}))}getRGroupAtomicIndices(){return this.rawAtomLines.map(((e,t)=>{if(e.includes("R#"))return t})).filter((e=>void 0!==e))}}class ze{constructor(e,t){this.monomerSymbol=t;const s=e.split("\n"),n=parseInt(s[3].substring(0,3)),r=parseInt(s[3].substring(3,6)),i=s.slice(4,4+n);this.atoms=new Ze(i);const o=s.slice(4+n,4+n+r);this.bonds=new qe(o),this.rGroups=new Ke(s,this.atoms,this.bonds),this.shiftMonomerToDefaultPosition()}deleteBondLineWithSpecifiedRGroup(e){this.rGroups.deleteBondLineWithSpecifiedRGroup(e)}shiftCoordinates(e){this.atoms.shift(e)}rotateCoordinates(e){this.atoms.rotate(e)}getBondLines(){return this.bonds.getBondLines()}getAtomLines(){return this.atoms.atomLines}removeRGroups(e){this.rGroups.removeRGroups(e)}replaceRGroupWithAttachmentAtom(e,t){this.rGroups.replaceRGroupWithAttachmentAtom(e,t)}getAttachmentAtomByRGroupId(e){return this.rGroups.getAttachmentAtomIdByRGroupId(e)}shiftR1GroupToOrigin(){const e=this.rGroups.getAtomicIdx(1);if(null===e)throw new Error(`Cannot find R1 group for monomer ${this.monomerSymbol}`);const{x:t,y:s}=this.atoms.atomCoordinates[e];this.atoms.shift({x:-t,y:-s})}alignR2AlongX(){const e=this.rGroups.getAtomicIdx(2);if(null===e)throw new Error(`Cannot find R2 group for monomer ${this.monomerSymbol}`);const t=this.atoms.atomCoordinates[e],s=t.y/t.x,n=Math.atan(s);if(isNaN(n))throw new Error(`Cannot calculate angle for R2 group for monomer ${this.monomerSymbol}`);this.rotateCoordinates(-n)}shiftMonomerToDefaultPosition(){this.shiftR1GroupToOrigin(),null!==this.rGroups.getAtomicIdx(2)&&this.alignR2AlongX()}shiftBonds(e){this.bonds.shift(e)}capRGroups(e){this.rGroups.capRGroups(e)}}class Xe{constructor(e){this.simplePolymer=e,this.polymerType=this.getPolymerType(),this.idx=this.getIdx();const{monomers:t,monomerTypes:s}=this.getMonomerSymbolsAndTypes();this.monomers=t,this.monomerTypes=s}get id(){return this.polymerType+this.idx.toString()}getPolymerType(){const e=new RegExp("(PEPTIDE|RNA)[0-9]+{"),t=this.simplePolymer.match(e);if(!t)throw new Error(`Unsupported polymer type in ${this.simplePolymer}`);return t[1]}getIdx(){const e=new RegExp(`${this.polymerType}([0-9]+){`),t=this.simplePolymer.match(e);if(!t)throw new Error(`Cannot parse simple polymer id from ${this.simplePolymer}`);return parseInt(t[1])}getMonomerSymbolsAndTypes(){const e=new RegExp(`${this.polymerType}${this.idx}{|}`,"g"),t=this.simplePolymer.replace(e,"").split("."),s=[],n=[];return t.forEach((e=>{const t=e.split(/\(|\)/).map((e=>e.replace(/[\[\]]/g,"")));s.push(...t);const r=t.map(((e,t)=>t%2==0?0:1));n.push(...r)})),{monomers:s,monomerTypes:n}}getBondData(){const e=[],t=this.monomerTypes.map(((e,t)=>{if(0===e)return t})).filter((e=>void 0!==e)),s=this.monomerTypes.map(((e,t)=>{if(1===e)return t})).filter((e=>void 0!==e));for(let s=0;s<t.length-1;s++){const n=t[s],r=t[s+1];e.push([{monomerIdx:n,rGroupId:2},{monomerIdx:r,rGroupId:1}])}for(let t=0;t<s.length;t++){const n=s[t],r=n-1;e.push([{monomerIdx:r,rGroupId:3},{monomerIdx:n,rGroupId:1}])}return e}}class Je{constructor(e){const t=e.split("|");t.forEach((e=>this.validateConnectionItem(e))),this.connectionItems=t}validateConnectionItem(e){const t="(PEPTIDE|RNA)",s=new RegExp(`${t}[0-9]+,${t}[0-9]+,[0-9]+:R[0-9]+-[0-9]+:R[0-9]+`,"g");if(!e.match(s))throw new Error(`Cannot parse connection item from ${e}`)}getConnectionData(){const e=[];return this.connectionItems.forEach((t=>{const s=[],n=t.split(",");n[2].split("-").forEach(((e,t)=>{const r=n[t],i=e.split(":"),o={monomerIdx:parseInt(i[0])-1,rGroupId:parseInt(i[1].slice(1))};s.push({polymerId:r,bond:o})})),e.push(s)})),e}}class Qe{constructor(e){this.helm=e;const t=this.helm.split("$"),s=t[0].split("|");this.simplePolymers=s.map((e=>new Xe(e))),""!==t[1]&&(this.connectionList=new Je(t[1])),this.bondData=this.getBondData()}toString(){return this.helm}getPolymerTypeByMonomerIdx(e){return this.getSimplePolymerByMonomerIdx(e).polymerType}getSimplePolymerByMonomerIdx(e){const t=this.getMonomerIdxShifts(),s=Object.values(t).sort(((e,t)=>e-t)).find((t=>e>=t));if(void 0===s)throw new Error(`Cannot find simple polymer for monomer ${e}`);const n=Object.keys(t).find((e=>t[e]===s));return this.simplePolymers.find((e=>e.id===n))}shiftBondMonomerIds(e,t){t.forEach((t=>{t.forEach((t=>{t.monomerIdx+=e}))}))}getMonomerIdxShifts(){const e={};let t=0;return this.simplePolymers.forEach((s=>{e[s.id]=t,t+=s.monomers.length})),e}getBondData(){const e=this.getMonomerIdxShifts(),t=[];return this.simplePolymers.forEach((s=>{const n=s.getBondData(),r=e[s.id];this.shiftBondMonomerIds(r,n),t.push(...n)})),this.connectionList&&this.connectionList.getConnectionData().forEach((s=>{const n=[];s.forEach((t=>{const s=e[t.polymerId],r=t.bond;r.monomerIdx+=s,n.push(r)})),t.push(n)})),t}}class et{constructor(e){this.monomerWrappers=[],this.helm=new Qe(e),this.bondedRGroupsMap=new Map,this.helm.bondData.forEach((e=>{e.forEach((e=>{const t=e.monomerIdx,s=e.rGroupId;this.bondedRGroupsMap.get(t)||this.bondedRGroupsMap.set(t,[]),this.bondedRGroupsMap.get(t).push(s)}))}))}addMonomer(e,t,s){const n=this.helm.getPolymerTypeByMonomerIdx(t),r=new Ye(e,n);r.shiftCoordinates(s),this.monomerWrappers.push(r)}removeRGroups(){this.monomerWrappers.forEach(((e,t)=>{this.bondedRGroupsMap.has(t)&&e.removeBondedRGroups(this.bondedRGroupsMap.get(t)),e.capTrailingRGroups()}))}getAtomNumberShifts(){const e=[];let t=0;return this.monomerWrappers.forEach((s=>{e.push(t),t+=s.getAtomLines().length})),e}restoreBondsBetweenMonomers(){this.helm.bondData.forEach((e=>{const t=e.map((e=>e.monomerIdx)),s=e.map((e=>e.rGroupId)),n=t.map((e=>this.monomerWrappers[e])),r=n[1].getAttachmentAtomByRGroupId(s[1]);n[0].replaceRGroupWithAttachmentAtom(s[0],r),n[1].deleteBondLineWithSpecifiedRGroup(s[1])}))}compileToMolfile(){const e=[],t=[];this.removeRGroups();const s=this.getAtomNumberShifts();this.monomerWrappers.forEach(((e,t)=>{e.shiftBonds(s[t])})),this.restoreBondsBetweenMonomers(),this.monomerWrappers.forEach((s=>{e.push(...s.getAtomLines()),t.push(...s.getBondLines())}));const n=e.length;if(n>999)throw new Error(`Atom count in polymer ${this.helm.toString()} is ${n} and exceeds 999`);const r=t.length;return["\nDatagrok\n",`${n.toString().padStart(3," ")}${r.toString().padStart(3," ")} 0 0 1 0 0 V2000`,e.join("\n"),t.join("\n"),"M END\n"].join("\n")}}s(1047),a.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),["1","1A","1C","2","4","4A","4B","5","6"].join(ce.CI);var tt=s(8601),st=s(3277);function nt(e){const t=["Embed_X","Embed_Y"],s=e.columns.names().filter((e=>e.includes(t[0]))).length+1;return t.map((e=>`${e}_${s}`))}const rt=new We;function it(){return Le.A.instance}function ot(){return Le.A.instance.getBioLib()}async function at(e,t,n,r,u,d,m,p){if(!(0,Ge.n)(t,"Activity Cliffs"))return;const f=nt(e),g={units:t.getTag(a.TAGS.UNITS),aligned:t.getTag("aligned"),separator:t.getTag("separator"),alphabet:t.getTag("alphabet")},y=d,b=t,w=async()=>await async function(e,t,n,r,l,u,d,m,p,f,g,y,b,w,C,v){O++;const T=u/100;let A,S=!1;const _=y.inputs,E=await y.apply({[_[0].name]:t,[_[1].name]:d,...p.preprocessingFuncArgs??{}});let P=[];if(m===c){const t=await function(e,t,n,r,i,o,a=10){const l=new Worker(new URL(s.p+s.u(709),s.b));let c;return l.postMessage({data:e,threshold:t,weights:n,aggregationMethod:r,distanceFns:i,distanceFnArgs:o,maxIterations:a}),{promise:new Promise(((e,t)=>{c=e,l.onmessage=t=>{setTimeout((()=>l.terminate()),100),e(t.data.res)},l.onerror=e=>{setTimeout((()=>l.terminate()),100),t(e)}})),terminate:()=>{try{c(null),l.terminate()}catch(e){console.error(e)}}}}([E.entries],u,[1],"MANHATTAN",[d],[E.options??{}],p?.maxIterations??5).promise;e.columns.addNewInt(e.columns.getUnusedName("MCL Cluster")).init((e=>t.clusters[e])),P=[t.embedX,t.embedY]}else P=await R([E.entries],m,[d],[1],"MANHATTAN",{...p,distanceFnArgs:[E.options??{}]});if(P.length!==n.length)throw new Error("Number of axes names should be equal to number of embedding dimensions");for(let t=0;t<P.length;++t)e.columns.addNewFloat(n[t]).init((e=>P[t][e]));const N=await(new $).calc(E.entries,d,T,E.options),L=await async function(e,t){const s=e.distance.map(((s,n)=>{const r=Math.abs(t.get(e.i[n])-t.get(e.j[n]));return 0!=s?r/s:1/0})),n=e.distance.map((e=>1-e)),r=e.i,i=e.j,o=new Set;return e.distance.forEach(((t,s)=>{o.add(e.i[s]),o.add(e.j[s])})),{simVals:n,saliVals:s,n1:r,n2:i,cliffsMolIds:o}}(N,l),I=function(e,t,s,n,r,i){const o=new Array(e).fill(0);for(let e=0;e!=s.length;++e)t[e]!=1/0&&(i.get(s[e])>i.get(n[e])?o[s[e]]+=t[e]:o[n[e]]+=t[e]);return a.Column.fromList("double",`sali_${r[0].substring(r[0].lastIndexOf("_"))}`,o)}(t.length,L.saliVals,L.n1,L.n2,n,l);e.columns.add(I);const U=function(e,t){const s=a.BitSet.create(e.rowCount);for(let n=0;n<e.rowCount;n++)s.set(n,t.has(n));return s}(e,L.cliffsMolIds),j=function(e){const t=e.filter((e=>e!==1/0)),s=t.reduce(((e,t)=>Math.min(e,t)),Number.MAX_VALUE),n=t.reduce(((e,t)=>Math.max(e,t)),s);return{max:n,min:s}}(L.saliVals),Y=.8/(j.max-j.min),K=i.shell.getTableView(e.name),q=K.addViewer(a.VIEWER.SCATTER_PLOT,{xColumnName:n[0],yColumnName:n[1],size:I.name,color:l.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:r}),Z=function(e,t,s,n,r,i,o,l){const c={from:new Uint32Array(t.n1.length),to:new Uint32Array(t.n1.length),opacities:new Float32Array(t.n1.length),colors:new Array(t.n1.length),widths:new Float32Array(t.n1.length)};for(let s=0;s<t.n1.length;s++)c.from[s]=t.n1[s],c.to[s]=t.n2[s],c.opacities[s]=t.saliVals[s]===1/0?1:.2+(t.saliVals[s]-o.min)*l,c.colors[s]=e.selection.get(c.from[s])&&e.selection.get(c.to[s])?"255,255,0":"0,128,0",c.widths[s]=1;const h=a.DataFrame.create(c.from.length);return B.forEach(((e,t)=>{h.columns.addNewString(e).init((e=>s.get(0===t?c.from[e]:c.to[e]))),function(e,t){Object.keys(t).forEach((s=>{e.tags[s]=t[s]}))}(h.col(e),i),h.col(e).semType=r})),h.columns.addNewFloat(D).init((e=>Math.abs(n.get(c.from[e])-n.get(c.to[e])))),h.columns.addNewInt(W).init((e=>e)),h.columns.addNewFloat(G).init((e=>t.saliVals[e])),h.columns.addNewFloat(H).init((e=>t.simVals[e])),h.name=`${k}${O}`,{lines:c,linesDf:h}}(e,L,t,l,f,g,j,Y);Z.lines.skipMultiLineCalculation=!0,Z.linesDf.col(G).setTag("description","Structure−Activity Landscape Index (activity difference divided by 1 minus similarity)");const z=new M(q,n[0],n[1],Z.lines,x.none),X=C?C(Z.linesDf,B).sort([G],[!1]):Z.linesDf.plot.grid().sort([G],[!1]);X.col(W)&&(X.col(W).visible=!1),e.temp[".cliffsDfGrid"]=X;const J=o.button(`${Z.linesDf.rowCount} cliffs`,(()=>{K.dockManager.dock(X,"down",null,"Activity cliffs",v??.2)}));J.classList.add("scatter_plot_link","cliffs_grid"),q.root.append(J);const Q=o.switchInput("Show 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s=q.dataFrame.getSortedOrder(K.grid.sortByColumns,K.grid.sortTypes);K.grid.scrollToCell(t.name,s.indexOf(q.dataFrame.currentRowIdx))}),1e3)}})),Z.linesDf.onSelectionChanged.subscribe((t=>{setTimeout((()=>(()=>{const t=a.BitSet.create(e.rowCount);for(let e=0;e<Z.linesDf.rowCount;e++){const s=Z.linesDf.selection.get(e);s&&(t.set(Z.lines.from[e],!0),t.set(Z.lines.to[e],!0)),Z.lines.colors[e]=s?"255,255,0":"0,128,0"}e.selection.copyFrom(t),z.linesToRender=Z.lines})()),100)})),e.onSelectionChanged.subscribe((t=>{!1===e.selection.anyTrue&&"number"==typeof t&&(S?S=!1:(e=>{e.selection.setAll(!1);for(let e=0;e<Z.lines.colors.length;e++)Z.lines.colors[e]="0,128,0";z.linesToRender=Z.lines})(X.dataFrame))})),z.lineClicked.subscribe((t=>{if(S=!0,z.currentLineId=t.id,-1!==t.id){const s=Z.linesDf.selection.clone();setTimeout((()=>{t.event.ctrlKey?(s.set(t.id,!s.get(t.id)),Z.linesDf.selection.copyFrom(s)):(Z.linesDf.currentRowIdx!==t.id&&(Z.linesDf.currentRowIdx=t.id,e.currentRowIdx=Z.lines.from[t.id]),Z.linesDf.selection.copyFrom(s));const n=Z.linesDf.getSortedOrder(X.sortByColumns,X.sortTypes);X.scrollToCell(B[0],n.indexOf(t.id))}),500)}})),z.lineHover.pipe((0,h.debounceTime)(500)).subscribe((s=>{-1!==s.id&&-1===e.mouseOverRowIdx&&o.tooltip.show(b({lineId:s.id,points:[Z.lines.from[s.id],Z.lines.to[s.id]],df:e,seqCol:t,activityCol:l}),s.x,s.y)})),q.addProperty("similarityLimit","double",T),A=function(){const e=o.accordion(),t=o.element("i");return t.className="grok-icon svg-icon svg-view-layout",e.addTitle(o.span([t,o.label("Activity cliffs")])),e.addPane("Cliff Details",(()=>o.divText("Cliff has not been selected")),!0),i.shell.o=e.root,e}(),q}(e,b,f,"Activity cliffs",n,r,y,u,{...p??{}},a.SEMTYPE.MACROMOLECULE,g,m,Pe,$e,Ne),C=u===l.A.UMAP?2e5:2e4,v=u===l.A.UMAP?5e3:2e3;if(e.rowCount>C)return void i.shell.warning(`Too many rows, maximum for sequence activity cliffs is ${C}`);const T=a.TaskBarProgressIndicator.create("Running sequence activity cliffs ...");return new Promise(((t,s)=>{e.rowCount>v&&!p?.[st.sS]?o.dialog().add(o.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{w().then((e=>t(e))).catch((e=>s(e)))})).onCancel((()=>{t(void 0)})).show():w().then((e=>t(e))).catch((e=>s(e)))})).catch((e=>{const[t,s]=(0,X.yf)(e);throw rt.logger.error(t,void 0,s),e})).finally((()=>{T.close()}))}async function lt(e,t,n,r,l,c,h,u){if((0,Ge.n)(t,"Sequence Space"))return c||(c=a.Func.find({name:"macromoleculePreprocessingFunction",package:"Bio"})[0]),h??(h={}),await async function(e,t,n,r,l,c,h,u=!0,d=!1,m={preprocessingFuncArgs:[]},p={}){const f={showXAxis:!1,showYAxis:!1,showXSelector:!1,showYSelector:!1};if(t.length!==r.length||t.length!==c.length||t.length!==l.length||t.length!==m.preprocessingFuncArgs.length)throw new Error("columns, metrics and preprocessing functions, weights and function argumentsmust have the same length");const g=i.shell.tableView(e.name)??i.shell.addTableView(e),y=async()=>{const y=a.TaskBarProgressIndicator.create(`Initializing ${p.scatterPlotName??"dimensionality reduction"} ...`);let b;try{const w=nt(e);function C(t,s,n){let r=null,i=null;e.columns.names().includes(w[0])?(r=e.columns.byName(w[0]),i=e.columns.byName(w[1])):(r=e.columns.add(a.Column.float(w[0],e.rowCount)),i=e.columns.add(a.Column.float(w[1],e.rowCount)),u&&!b&&(b=g.scatterPlot({...f,x:w[0],y:w[1],title:p.scatterPlotName??"Embedding space"}))),p[st.Ec]&&(b?.root&&o.setUpdateIndicator(b.root,!1),r.init((e=>n[0]?n[0][e]:void 0)),i.init((e=>n[1]?n[1][e]:void 0)));const l=t/s*100;y.update(l,`Running ${p.scatterPlotName??"dimensionality reduction"}... ${l.toFixed(0)}%`)}async function v(){e.columns.add(a.Column.float(w[0],e.rowCount)),e.columns.add(a.Column.float(w[1],e.rowCount));let s=null;u&&(b=g.scatterPlot({...f,x:w[0],y:w[1],title:p.scatterPlotName??"Embedding space"}),o.setUpdateIndicator(b.root,!0));const d=i.events.onViewerClosed.subscribe((e=>{const t=e.args.viewer;t?.getOptions()?.look?.title&&b?.getOptions()?.look?.title&&t?.getOptions()?.look?.title===b?.getOptions()?.look?.title&&(i.events.fireCustomEvent(L,{}),d.unsubscribe(),s?.(),y.close())})),v=new Promise((async(e,i)=>{try{s=e;const i=[];for(let e=0;e<c.length;++e){const s=c[e];if(m.distanceFnArgs||(m.distanceFnArgs=[]),s){const n=s.inputs[0].name,o=s.inputs[1].name,{entries:a,options:l}=await s.apply({[n]:t[e],[o]:r[e],...m.preprocessingFuncArgs[e]??{}});i.push({entries:a,options:l}),m.distanceFnArgs.push(l)}else{const s=t[e].toList(),n={};i.push({entries:s,options:n}),m.distanceFnArgs.push(n)}}e(await R(i.map((e=>e.entries)),n,r,l,h,m,p[st.sS]?void 0:C))}catch(e){i(e)}})),T=await v;return y.close(),d.unsubscribe(),T}const T=await v();if(d&&T){const A=a.TaskBarProgressIndicator.create("Clustering embeddings ...");try{const S=await function(e,t,n,r){return De(this,void 0,void 0,(function*(){return new Promise((function(i,o){const a=new Worker(new URL(s.p+s.u(796),s.b));a.postMessage({embedX:e,embedY:t,minPts:r,epsilon:n}),a.onmessage=({data:{error:e,clusters:t}})=>{a.terminate(),e?o(e):i(t)}}))}))}(T[0],T[1],m.dbScanEpsilon??.01,m.dbScanMinPts??4),_=e.columns.getUnusedName("Cluster");e.columns.addNewString(_).init((e=>S[e].toString())),b&&(b.props.colorColumnName=_)}catch(E){i.shell.error("Clustering embeddings failed"),console.error(E)}finally{A.close()}}if(T&&u&&b){o.setUpdateIndicator(b.root,!1);const P=e.columns.byName(w[0]),$=e.columns.byName(w[1]);return P.init((e=>T[0][e])),$.init((e=>T[1][e])),b.helpUrl="/help/compute/sequence-space",b}}catch(x){i.shell.error("Dimensionality reduction failed"),console.error(x),y.close(),b&&o.setUpdateIndicator(b.root,!1)}};return new Promise((async(t,s)=>{try{if(p.fastRowCount&&e.rowCount>p.fastRowCount&&!p[st.sS])o.dialog().add(o.divText("Analysis might take several minutes. Do you want to continue?")).onOK((async()=>{try{const e=await y();t(e)}catch(e){s(e)}})).onCancel((()=>t(void 0))).show();else{const e=await y();t(e)}}catch(e){s(e)}}))}(e,[t],n,[r],[1],[c],"MANHATTAN",l,u??!1,{...h,preprocessingFuncArgs:[h.preprocessingFuncArgs??{}]},{fastRowCount:1e4,scatterPlotName:"Sequence space",bypassLargeDataWarning:h?.[st.sS]})}async function ct(e,t,s){const n=a.TaskBarProgressIndicator.create("Converting to atomic level ...");try{await async function(e,t,s){if(0===a.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(s){const s=j.Cn.getOrCreate(t);return s.isHelm()||(t=s.convert(ce.r2.HELM)),void async function(e,t){const s=await async function(e,t){const s=new Ue(t,e),n=await s.convertToRdKitBeautifiedMolfileColumn();return n.semType=a.SEMTYPE.MOLECULE,n}(e,t);e.columns.add(s,!0),await i.data.detectSemanticTypes(e)}(e,t)}if(!(0,Ge.n)(t,"To Atomic Level"))return;const n=it().getBioLib(),r=await(0,tt.i0)(e,t,n);null!==r.col&&(e.columns.add(r.col,!0),await i.data.detectSemanticTypes(e)),r.warnings&&r.warnings.length>0&&i.shell.warning(o.list(r.warnings))}(e,t,s)}finally{n.close()}}function ht(e){return new Y.i(e).importFasta()}function ut(e){const t=j.Cn.getOrCreate(e).stats;return Object.keys(t.freq)}async function dt(e,t,s){return z(e,t,s,U.IDENTITY)}async function mt(e,t,s){return z(e,t,s,U.SIMILARITY)}},7983:(e,t,s)=>{"use strict";s.d(t,{QF:()=>c,pf:()=>l});var n=s(4469),r=(s(3870),s(976)),i=s(7241),o=(s(4293),s(8467)),a=s(8447);function l(e,t,s){const n=s?function(e,t){const s=`${t}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),n=e.charAt(0)===t,r=e.charAt(e.length-1)===t,i=e.replace(new RegExp(`^${s}|${s}$`,"g"),"");return n?r?`${s}${i}${s}`:`${s}${i}${s}|${s}${i}$`:r?`^${i}${s}|${s}${i}${s}`:`^${i}${s}|${s}${i}${s}|${s}${i}$`}(e,s):e,i=r.BitSet.create(t.length);for(let s=0;s<t.length;s++){const r=t.get(s);(r.match(n)||r===e)&&i.set(s,!0,!1)}return i}async function c(e,t){t.version!==t.temp["last-invalidated-version"]&&await async function(e,t){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${e.name}`);try{await(0,o.gw)(10);const t=new Map,s=await(0,i.D)(e,!0,t);e.temp["monomeric-mols"]=s,e.temp["monomers-dict"]=t,e.temp["last-invalidated-version"]=e.version}finally{s.close()}}(t);const s=r.Column.string("helm",1).init((t=>e));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,a.r2.HELM);const l=await(0,i.D)(s,!0,t.temp["monomers-dict"]);return(await n.functions.call("Chem:searchSubstructure",{molStringsColumn:t.temp["monomeric-mols"],molString:l.get(0),molBlockFailover:""})).get(0)}},2568:(e,t,s)=>{"use strict";s.d(t,{l:()=>a,n:()=>o});var n=s(4469),r=s(976),i=s(499);function o(e,t,s=[],r=[],i=!0){const[o,l]=a(e,t,s,r);return i&&!o&&n.shell.warning(l),o}function a(e,t,s=[],o=[]){let a=!0,l="";const c=i.Cn.getOrCreate(e);if(e.semType!==r.SEMTYPE.MACROMOLECULE)n.shell.warning(t+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const e=c.notation;if(s.length>0&&!s.some((t=>e.toUpperCase()==t.toUpperCase())))l=`${t} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((e=>`"${e}"`)).join(", ")} `}.`,a=!1;else if(!c.isHelm()){const e=c.alphabet;o.length>0&&!o.some((t=>e.toUpperCase()==t.toUpperCase()))&&(l=`${t} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((e=>`"${e}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}},3553:(e,t,s)=>{"use strict";s.d(t,{Of:()=>i,WY:()=>h,jB:()=>u,mU:()=>a,rs:()=>c});var n,r,i,o=s(8341);!function(e){e.SPLIT_COL="~split",e.ACTIVITY="~activity",e.ACTIVITY_SCALED="activity_scaled",e.ALIGNED_SEQUENCE="~aligned_sequence",e.AMINO_ACID_RESIDUE="AAR",e.POSITION="Pos",e.P_VALUE="pValue",e.MEAN_DIFFERENCE="Mean difference"}(n||(n={})),function(e){e.AAR="AAR",e.POSITION="Pos",e.SELECTION="selection"}(r||(r={})),function(e){e.MONOMER="Monomer",e.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",e.ACTIVITY="activity",e.ACTIVITY_SCALED="activityScaled"}(i||(i={}));const a="MSA";var l,c;!function(e){e.CELL_CHANGING="isCellChanging"}(l||(l={})),function(e){e.SEPARATOR="."}(c||(c={}));const h="3.3.1",u={pepsea:{gapOpen:1.53,gapExtend:0,method:o.Jy[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(e,t,s)=>{"use strict";s.d(t,{o:()=>i}),s(976),s(3870);var n=s(4469),r=(s(3336),s(8447),s(499));async function i(e,t,s){const i=r.Cn.getOrCreate(e).convert(t,s);e.dataFrame.columns.add(i);const o=await n.functions.call("Bio:detectMacromolecule",{col:i});return o&&(i.semType=o),await n.data.detectSemanticTypes(e.dataFrame),i}},7572:(e,t,s)=>{"use strict";s.d(t,{A:()=>h});var n=s(4469),r=s(6584),i=s(2832),o=s(3776),a=s(2428),l=s(3348);async function c(){const e=a.A.getInstance();return(await o.t.getInstance(e)).getValidLibraryPaths()}class h{constructor(){this._monomerLib=new i.B({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(e=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[t,s]=await Promise.all([c(),(0,r.nW)()]),n=t.filter((e=>{const t=!s.exclude.includes(e),n=0===s.explicit.length||s.explicit.includes(e);return t&&n})),o=await Promise.all(n.map((e=>this.readLibrary(r.BX,e).catch((t=>{const s=`Loading monomers from '${e}' error: ${t instanceof Error?t.message:t.toString()}`;return new i.B({},s)})))));this._monomerLib.updateLibs(o,e)}catch(e){const t=`Loading monomer libraries error: ${e instanceof Error?e.message:e.toString()}`;n.shell.warning(t);const s=e instanceof Error?e.stack:void 0;l._package.logger.error(t,void 0,s)}}))}async readLibrary(e,t){const s=a.A.getInstance(),n=await o.t.getInstance(s);return await n.loadLibraryFromFile(e,t)}async selectSpecifiedLibraries(e){const t=await this.getInvalidFileNames(e);if(t.length>0)throw new Error(`Cannot select libraries ${t}: no such library in the list`);const s=await(0,r.nW)();s.exclude=(await c()).filter((t=>!e.includes(t))),await(0,r.tW)(s)}async getInvalidFileNames(e){const t=await c();return e.filter((e=>!t.includes(e)))}static get instance(){return window.$monomerLibHelper||(window.$monomerLibHelper=new h),window.$monomerLibHelper}}},2428:(e,t,s)=>{"use strict";s.d(t,{A:()=>i});var n=s(701),r=s(442);class i{constructor(){this._libraryFilesUpdateSubject$=new n.BehaviorSubject([]),this._addLibraryFilesSubject$=new n.Subject,this._librarySelectionSubject$=new n.Subject}static getInstance(){return i._instance||(i._instance=new i),i._instance}getValidFilesPathList(){return this._libraryFilesUpdateSubject$.getValue()}async getValidLibraryPathsAsynchronously(){return new Promise((e=>{this._libraryFilesUpdateSubject$.pipe((0,r.skip)(1)).subscribe((t=>{e(t)}))}))}changeValidFilesPathList(e){this._libraryFilesUpdateSubject$.next(e)}get updateUIControlsRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get updateValidLibraryFileListRequested$(){return this._libraryFilesUpdateSubject$.pipe()}get addLibraryFileRequested$(){return this._addLibraryFilesSubject$.pipe()}addLibraryFile(){this._addLibraryFilesSubject$.next()}get librarySelectionRequested$(){return this._librarySelectionSubject$}updateLibrarySelectionStatus(e,t){this._librarySelectionSubject$.next([e,t])}}},3776:(e,t,s)=>{"use strict";s.d(t,{t:()=>m});var n=s(4469),r=s(976),i=s(6584),o=s(2832),a=s(5128),l=s.n(a),c=s(3351),h=s.n(c);class u{constructor(e){this.helmMonomerSchema=e;const t=new(l())({allErrors:!0,strictTuples:!1});h()(t),this.validateMonomerSchema=t.compile(this.helmMonomerSchema)}validateFile(e,t){const s=this.parseJson(e);return null!==s&&(Array.isArray(s)?this.validateJsonContent(s,t):(console.warn("Bio: Monomer Library File Validator: Invalid JSON format: The file must contain an array of monomers."),!1))}parseJson(e){try{return JSON.parse(e)}catch(e){return console.error("Bio: Monomer Library File Validator: Invalid JSON format:",e),null}}validateJsonContent(e,t){let s=!0;for(const n of e)if(s=this.validateMonomerSchema(n),!s){console.warn(`Bio: Monomer Library File Validator:\nfile ${t}\n monomer violating JSON schema:`,n,"\nError reason: ",this.validateMonomerSchema.errors,`\nThere may be other errors in ${t} since the validation is stopped after the first error.`," Please, verify that the monomer library file satisfies the JSON schema");break}return s}}var d=s(7572);class m{constructor(e,t){this.libraryFileValidator=e,this.libraryEventManager=t,this.libraryEventManager.updateValidLibraryFileListRequested$.subscribe((async()=>{await this.updateValidLibraryList()}))}static async getInstance(e){return m.instancePromise||(m.instancePromise=(async()=>{const t=await n.dapi.files.readAsText("System:AppData/Bio/tests/libraries/HELMmonomerSchema.json"),s=JSON.parse(t),r=new u(s);return new m(r,e)})()),m.instancePromise}async addLibraryFile(e,t){try{if(await this.libraryFileExists(t))return void n.shell.error(`File ${t} already exists`);await this.validateAgainstHELM(e,t),await n.dapi.files.writeAsText(i.BX+`${t}`,e),await this.updateValidLibraryList(),await n.dapi.files.exists(i.BX+`${t}`)?n.shell.info(`Added ${t} HELM library`):n.shell.error(`Failed to add ${t} library`)}catch(e){console.error(e),n.shell.error(`Failed to add ${t} library`)}}async deleteLibraryFile(e){try{await n.dapi.files.delete(i.BX+`${e}`),await this.updateValidLibraryList(),n.shell.info(`Deleted ${e} library`)}catch(t){console.error(t),await n.dapi.files.exists(i.BX+`${e}`)?n.shell.error(`Failed to delete ${e} library`):n.shell.warning(`File ${e} already deleted, refresh the list`)}}async loadLibraryFromFile(e,t){let s=[];const n=new r.FileSource(e),i=await n.readAsText(t);s=JSON.parse(i);const a={},l=[];return s.forEach((e=>{l.includes(e.polymerType)||(a[e.polymerType]={},l.push(e.polymerType)),a[e.polymerType][e.symbol]=e})),new o.B(a)}getValidLibraryPaths(){return this.libraryEventManager.getValidFilesPathList()}async getValidLibraryPathsAsynchronously(){return await this.libraryEventManager.getValidLibraryPathsAsynchronously()}async libraryFileExists(e){return await n.dapi.files.exists(i.BX+`${e}`)}async updateValidLibraryList(){const e=[],t=await this.getFilePathsAtDefaultLocation();if(!this.fileListHasChanged(t))return;for(const s of t){if(!s.endsWith(".json")){e.push(s);continue}const t=await n.dapi.files.readAsText(i.BX+`${s}`);this.isValidHELMLibrary(t,s)||e.push(s)}const s=t.filter((t=>!e.includes(t)));if(this.fileListHasChanged(s)&&(this.libraryEventManager.changeValidFilesPathList(s),d.A.instance.loadLibraries(!0)),s.some((e=>!e.endsWith(".json")))&&console.warn(`Wrong validation: ${s}`),e.length>0){const t=`Invalid monomer library files in ${i.BX}, consider fixing or removing them: ${e.join(", ")}`;console.warn(t)}}fileListHasChanged(e){const t=this.libraryEventManager.getValidFilesPathList();return e.length!==t.length||e.some(((e,s)=>e!==t[s]))}async validateAgainstHELM(e,t){if(!this.isValidHELMLibrary(e,t))throw new Error(`File ${t} does not satisfy HELM standard`)}isValidHELMLibrary(e,t){return this.libraryFileValidator.validateFile(e,t)}async getFilePathsAtDefaultLocation(){const e=(await n.dapi.files.list(i.BX)).map((e=>e.fullPath)),t=[];for(const s of e)await n.dapi.files.exists(s)&&t.push(s);return t.map((e=>e.substring(i.BX.length)))}}},2832:(e,t,s)=>{"use strict";s.d(t,{B:()=>i});var n=s(701),r=s(922);class i{constructor(e,t){this._monomers={},this._onChanged=new n.Subject,this._monomers=e,this.error=t}getMonomer(e,t){return e in this._monomers&&t in this._monomers[e]?this._monomers[e][t]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(e){const t={};return Object.keys(this._monomers[e]??{}).forEach((s=>{t[s]=this._monomers[e][s].molfile})),t}getMonomerSymbolsByType(e){return Object.keys(this._monomers[e])}getMonomerSymbolsByRGroup(e,t,s){let n=this.getMonomerSymbolsByType(t).map((e=>this.getMonomer(t,e)));return n=n.filter((e=>null!==e)),0===n.length?[]:(n=n.filter((t=>{if(!t?.rgroups)return!1;let s=t?.rgroups.length>=e;return r._.getInstance(t.molfile).atomTypes.map(((e,t)=>"R#"===e?t:-1)).filter((e=>-1!==e)),s&&(s=!0),s})),n.map((e=>e?.symbol)))}get onChanged(){return this._onChanged}_updateInt(e){const 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t.tools=this.tools,t.config=this.config,await t.init(),t}_parseTool(e){if("string"!=typeof e)return e;const t=e.split("/");if(2!=t.length&&3!=t.length)throw"Expecting '<tool>/<version>' or '<tool>/<program>/<version>'";return{tool:t[0],program:3==t.length?t[1]:t[0],version:t[t.length-1]}}}var P=s(850);class ${static getAvailableScales(){return Object.entries(this.scales).map((([e,t])=>e))}static getScale(e){return(0,P.hu)(!(void 0===this.scales[e]),`Scale '${e}' was not found.`),this.scales[e]}}$.scales={WimleyWhite:{"-":0,A:.17,C:-.24,D:-.07,E:-.01,F:-1.13,G:.01,H:.17,I:-.31,K:.99,L:-.56,M:-.23,N:.42,P:.45,Q:.58,R:.81,S:.13,T:.14,V:.07,W:-1.85,Y:-.94},categorial:{"-":0,A:1,C:2,D:3,E:4,F:5,G:6,H:7,I:8,K:9,L:10,M:11,N:12,P:13,Q:14,R:15,S:16,T:17,V:18,W:19,Y:20}};class x{constructor(e="categorial"){this.aa2num=$.getScale(e),this.num2aa={},Object.entries(this.aa2num).forEach((([e,t])=>this.num2aa[t]=e))}static _truncateSequence(e){let t=0,s=e.length;const n=["NH2","COOH"];if(e.startsWith(n[0])){const s=n[0].length;(0,P.hu)("-"==e[s],`Wrong sequence format: ${n[0]} without following '-' in '${e}'.`),t=s}if(e.endsWith(n[1])){const t=n[1].length+1;(0,P.hu)("-"==e[s-t],`Wrong sequence format: ${n[1]} without '-' precending in '${e}'.`),s-=t}return e.substring(t,s)}static _dropDefises(e){return e.replace(/(-)([^-]+)/g,"$2")}static clean(e){return x._dropDefises(x._truncateSequence(e))}encode(e){const t=e.length,s=new Array(t).fill(0);for(let n=0;n<t;++n){const t=e[n];(0,P.hu)(t in this.aa2num,`Unknown char '${t}' found in sequence '${e}'`),s[n]=this.encodeLettter(t)}return s}encodeLettter(e){return this.aa2num[e]}decode(e){let t="";for(let s=0;s<e.length;++s){const n=e[s];(0,P.hu)(n in this.num2aa,`Unknown code '${n}' found in vector '${e}'`),t+=this.num2aa[n]}return t}}var N=s(3553);const M="input.fa",L="result.fasta";function I(e){return e.reduce(((e,t,s)=>e+`>sample${s+1}\n${t}\n`),"")}async function R(e,t=!1,s="",i=null,o,a,l){let c=e.toList();t&&(c=c.map((e=>x.clean(e).replace(/\-/g,""))));const h=e.length;i??(i=n.Column.string("Clusters",h).init("0")),i.type!=n.COLUMN_TYPE.STRING&&(i=i.convertTo(n.TYPE.STRING)),i.compact();const u=i.categories,d=i.getRawData(),m=new Array(u.length),p=new Array(u.length);for(let e=0;e<h;++e){const t=d[e];(m[t]??(m[t]=[])).push(c[e]),(p[t]??(p[t]=[])).push(e)}const f=await new E(["base/1.0.0",{tool:"kalign",version:N.WY,reinit:!0}]),g=n.Column.string(s,h);for(let e=0;e<u.length;++e){const t=I(m[e]);await f.fs.writeFile(M,t);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,n=await f.exec(`kalign ${M} -f fasta -o ${L}${s}`);console.warn(n);const i=await f.cat(L);if(!i)throw new Error("kalign output no result");const c=new r.i(i).sequencesArray,h=p[e];for(let e=0;e<c.length;++e)g.set(h[e],c[e])}const y=e.getTag(n.TAGS.UNITS),b=e.getTag("alphabet");return 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n=f.indexOf(s),r=e.get(t);r&&(g[n]??(g[n]=[])).push({ID:t.toString(),HELM:r})}const y=new Array(p);for(const e of g){const t=(await u(m.id,e,s,l,h)).Alignment;for(const e of t)y[parseInt(e.ID)]=Object.entries(e).filter((e=>!c.includes(e[0]))).map((e=>"-"!==e[1]?e[1]:"")).join(o.rs.SEPARATOR)}const b=r.Column.fromStrings(t,y);return b.setTag(r.TAGS.UNITS,i.r2.SEPARATOR),b.setTag("separator",o.rs.SEPARATOR),b.setTag("aligned","SEQ.MSA"),b.setTag("alphabet","UN"),b.setTag(".alphabetIsMultichar","true"),b.semType=r.SEMTYPE.MACROMOLECULE,b}async function u(e,t,s,r,i){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(t)},a=`/align?method=${s}&gap_open=${r}&gap_extend=${i}`,l=await n.dapi.docker.dockerContainers.request(e,a,o);return JSON.parse(l??"{}")}},9943:(e,t,s)=>{"use strict";s.d(t,{i$:()=>a,sK:()=>l}),s(976),s(3870),s(4469);var n=s(6414),r=s.n(n),i=s(8447);s(499);const o=60;function a(e,t,s=o,n="\n"){const 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i.Point((e.clientX-s.left)*t,(e.clientY-s.top)*t)},i.Rect.prototype.contains=function(e,t){return this.left<=e&&e<=this.right&&this.top<=t&&t<=this.bottom};class T{constructor(e=0,t){this.valueList=null,this.valueIdx=0,this.value=this.rowCount=e,this.bounds=t}push(e){this.valueList||(this.valueList=new Array(this.rowCount),this.valueIdx=0),this.valueList[this.valueIdx]=e,++this.valueIdx}aggregate(e){this.value=e(this.valueList)??0,this.valueList=null}}class A{get label(){return this._label?this._label:this.name}constructor(e,t,s,n){this.sumRowCount=0,this.pos=e,this.name=t,this._freqs=s??{},n?.sumRowCount&&(this.sumRowCount=n.sumRowCount),n?.sumValueForHeight&&(this.sumPlotValue=n.sumValueForHeight),n?.label&&(this._label=n.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(e){return e in this._freqs}getFreq(e){let t=this._freqs[e];return t||(t=this._freqs[e]=new T),t}aggregate(e){const t=function(e){return t=>{const s=function(e){let t;const s="agg";return t=e instanceof 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d=h*c+(n-u-1);const p=Object.entries(this._freqs).sort(((t,s)=>e(t[0])||e(s[0])?e(t[0])&&e(s[0])?0:e(t[0])?-1:1:s[1].value-t[1].value));for(const[e,n]of p){const e=u*n.plotValue/this.sumPlotValue;n.bounds=new i.Rect((t-s)*c*a,d,l*c,e),d+=e}}render(e,t,s,n,r,i){for(const[o,a]of Object.entries(this._freqs))if(!t(o)){const t=(0,d.GU)(o,5),l=a.bounds,c=l.left;e.resetTransform(),e.strokeStyle="lightgray",e.lineWidth=1,e.rect(c,l.top,l.width,l.height),e.fillStyle=i.get(o)??i.get("other"),e.textAlign="left",e.font=s;const h=e.measureText(t);e.setTransform(l.width/h.width,0,0,l.height/r,c,l.top),e.fillText(t,0,-n)}}getMonomerAt(e,t){const s=Object.entries(this._freqs).find((([s,n])=>n.bounds.contains(e,t)));return s?s[0]:void 0}buildCompositionTable(e){return(0,C._)(e,Object.assign({},...Object.entries(this._freqs).map((([e,t])=>({[e]:t.rowCount})))))}}!function(e){e.STYLE="Style",e.BEHAVIOR="Behavior",e.LAYOUT="Layout",e.DATA="Data"}(b||(b={})),function(e){e.sequenceColumnName="sequenceColumnName",e.valueAggrType="valueAggrType",e.valueColumnName="valueColumnName",e.startPositionName="startPositionName",e.endPositionName="endPositionName",e.skipEmptySequences="skipEmptySequences",e.skipEmptyPositions="skipEmptyPositions",e.shrinkEmptyTail="shrinkEmptyTail",e.backgroundColor="backgroundColor",e.positionHeight="positionHeight",e.positionWidth="positionWidth",e.verticalAlignment="verticalAlignment",e.horizontalAlignment="horizontalAlignment",e.fixWidth="fixWidth",e.fitArea="fitArea",e.minHeight="minHeight",e.maxHeight="maxHeight",e.showPositionLabels="showPositionLabels",e.positionMarginState="positionMarginState",e.positionMargin="positionMargin",e.filterSource="filterSource"}(w||(w={}));const S=m.vS;var _;!function(e){e[e.None=0]="None",e[e.Render=1]="Render",e[e.Layout=1]="Layout",e[e.Freqs=2]="Freqs"}(_||(_={}));const E=new class{constructor(){this.render=20}};class P extends i.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===m.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===m.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.initialized=!1,this.palette=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewerId=++P.viewerCounter,this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new h.Subject,this._onFreqsCalculated=new h.Subject,this._onLayoutCalculated=new h.Subject,this.requestedRenderLevel=_.Freqs,this.renderRequest=new h.Subject,this._onRendered=new h.Subject,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(w.sequenceColumnName,S.sequenceColumnName,{category:b.DATA});const e=[i.AGG.KEY,i.AGG.PIVOT,i.AGG.MISSING_VALUE_COUNT,i.AGG.SKEW,i.AGG.KURT,i.AGG.SELECTED_ROWS_COUNT],t=Object.values(i.AGG).filter((t=>!e.includes(t)));this.valueAggrType=this.string(w.valueAggrType,S.valueAggrType,{category:b.DATA,choices:t}),this.valueColumnName=this.string(w.valueColumnName,S.valueColumnName,{category:b.DATA}),this.startPositionName=this.string(w.startPositionName,S.startPositionName,{category:b.DATA}),this.endPositionName=this.string(w.endPositionName,S.endPositionName,{category:b.DATA}),this.skipEmptySequences=this.bool(w.skipEmptySequences,S.skipEmptySequences,{category:b.DATA}),this.skipEmptyPositions=this.bool(w.skipEmptyPositions,S.skipEmptyPositions,{category:b.DATA}),this.shrinkEmptyTail=this.bool(w.shrinkEmptyTail,S.shrinkEmptyTail,{category:b.DATA}),this.backgroundColor=this.int(w.backgroundColor,S.backgroundColor,{category:b.STYLE}),this.positionHeight=this.string(w.positionHeight,S.positionHeight,{category:b.STYLE,choices:Object.values(m.ES)}),this._positionWidth=this.positionWidth=this.float(w.positionWidth,S.positionWidth,{category:b.STYLE}),this.verticalAlignment=this.string(w.verticalAlignment,S.verticalAlignment,{category:b.LAYOUT,choices:Object.values(m.vw)}),this.horizontalAlignment=this.string(w.horizontalAlignment,S.horizontalAlignment,{category:b.LAYOUT,choices:Object.values(m.iD)}),this.fixWidth=this.bool(w.fixWidth,S.fixWidth,{category:b.LAYOUT,userEditable:!1}),this.fitArea=this.bool(w.fitArea,S.fitArea,{category:b.LAYOUT}),this.minHeight=this.float(w.minHeight,S.minHeight,{category:b.LAYOUT}),this.maxHeight=this.float(w.maxHeight,S.maxHeight,{category:b.LAYOUT}),this.showPositionLabels=this.bool(w.showPositionLabels,S.showPositionLabels,{category:b.LAYOUT}),this.positionMarginState=this.string(w.positionMarginState,S.positionMarginState,{category:b.LAYOUT,choices:Object.values(m.dE)});let s=0;"auto"===this.positionMarginState&&(s=4),this.positionMargin=this.int(w.positionMargin,s,{category:b.LAYOUT,min:0,max:16}),this.filterSource=this.string(w.filterSource,S.filterSource,{category:b.BEHAVIOR,choices:Object.values(m.Ct)}),this.slider=r.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=r.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%",this.viewSyncer=new y.c(v._package.logger)}viewerToLog(){return`WebLogoViewer<${this.viewerId}>`}setData(){const e=`${this.viewerToLog()}.setData()`;v._package.logger.debug(`${e}, in`),this.viewSyncer.sync(`${e}`,(async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),this.updateSeqCol(),this.updateEditors(),this.viewed||(await this.buildView(),this.viewed=!0)}finally{this.setDataInProgress=!1}}})),v._package.logger.debug(`${e}, out`)}async destroyView(){for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[];const e=this.dataFrame?"data":"null";v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${e} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const e=this.dataFrame?"data":"null";v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${e} ) start`),window.devicePixelRatio,this.viewSubs.push(i.debounce(this.renderRequest,E.render).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=r.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=r.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=r.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,r.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(r.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,h.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),this.render(_.Freqs,"buildView"),v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(_.Layout,"rootOnSizeChanged")}updateEditors(){this.props.getProperty(w.valueColumnName).choices=c()(this.dataFrame.columns.numerical).map((e=>e.name)).toArray()}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,d.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=u.Cn.getOrCreate(this.seqCol),this.palette=(0,d.dQ)(this.seqCol),this.render(_.Freqs,"updateSeqCol()"),this.error=null}catch(e){throw this.seqCol=null,this.error=e instanceof Error?e:new Error(e.toString()),e}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.palette=null)}}getFilter(){let e;switch(this.filterSource){case m.Ct.Filtered:e=this.dataFrame.filter;break;case m.Ct.Selected:e=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return e}setSliderVisibility(e){e?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(e){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(e):this.fitArea?this.calcLayoutFitArea(e):this.calcLayoutNoFitArea(e),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(e){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const t=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=m.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${t}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=t*e,this.canvas.height=s*e}calcLayoutNoFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=Math.min(this.root.clientWidth,t);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${n}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+6}px`),this.host.style.width=`${this.host}px`;const r=t>n;if(this.setSliderVisibility(r),r){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+s,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-s),this.slider.setValues(0,Math.max(this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=n*e,this.canvas.height=s*e}calcLayoutFitArea(e){if(!this.host||!this.canvas||!this.slider)return;const t=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=t>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/t:0,r=this.root.clientHeight/s,i=Math.max(1,Math.min(n,r));this._positionWidth=this.positionWidth*i,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=i*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===m.vw.TOP?"start":this.verticalAlignment===m.vw.MIDDLE?"center":this.verticalAlignment===m.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const c=o>l;if(this.setSliderVisibility(c),c){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let e=Math.min(Math.max(0,this.slider.min),this.Length-.001),t=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;t=Math.min(Math.max(e,0)+s,this.Length-.001),e=Math.max(0,Math.min(t,this.Length-.001)-s),this.slider.setValues(0,Math.max(0,this.Length-.001),e,t)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*e,this.canvas.height=a*e}onPropertyChanged(e){switch(super.onPropertyChanged(e),e.name){case w.sequenceColumnName:this.updateSeqCol();break;case w.sequenceColumnName:case w.startPositionName:case w.endPositionName:case w.filterSource:case w.shrinkEmptyTail:case w.skipEmptyPositions:case w.positionHeight:case w.valueColumnName:case w.valueAggrType:this.render(_.Freqs,`onPropertyChanged( ${e.name} )`);break;case w.minHeight:case w.maxHeight:case w.positionWidth:case w.showPositionLabels:case w.fixWidth:case w.fitArea:case w.horizontalAlignment:case w.verticalAlignment:case w.positionMargin:case w.positionMarginState:this.render(_.Layout,`onPropertyChanged(${e.name})`);break;case w.backgroundColor:this.render(_.Render,`onPropertyChanged(${e.name})`)}}onTableAttached(){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}detach(){const e=`${this.viewerToLog()}.detach()`;v._package.logger.debug(`${e}, in`);const t=super.detach.bind(this);this.viewSyncer.sync(`${e}`,(async()=>{this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())})),v._package.logger.debug(`${e}, out`)}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(e,t){const s=e.x,n=Math.floor(e.x/(this._positionWidthWithMargin*t)+Math.floor(this.slider.min)),r=this.positions[n];if(!r)return[null,null,null];const i=r.getMonomerAt(s,e.y);return void 0===i?[r,null,null]:[r,i,r.getFreq(i)]}_nullSequence(e="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(e).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=c()(this.positions).filter((e=>{const t=this.unitsHandler.defaultGapSymbol;return!e.hasMonomer(t)||e.getFreq(t).rowCount!==e.sumRowCount})).toArray())}render(e,t){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${e}, reason='${t}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,e),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(e){if(v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( renderLevel=${e} ), start `),this.msgHost&&(this.seqCol&&!this.palette?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.palette||null==this.host||null==this.slider)return;const t=window.devicePixelRatio,s=this.showPositionLabels?12:0;if(e>=_.Freqs&&(()=>{if(v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const e=this.getFilter(),t=0===e.trueCount?this.unitsHandler.maxLength:c().enumerate(this.unitsHandler.splitted).map((([t,s])=>e.get(s)&&t?t.length:0)).reduce(((e,t)=>Math.max(e,t)),0),s=this.seqCol.getTag(".positionNames"),n=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(d.CI).map((e=>e.trim())):[...Array(t).keys()].map((e=>`${e+1}`)),this.positionLabels=n?n.split(d.CI).map((e=>e.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):t-1;const r=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=u.Cn.getOrCreate(this.seqCol);const o=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(o);for(let e=0;e<r;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new A(this.startPosition+e,t,{},{label:s})}const a=this.dataFrame.rowCount,l=this.unitsHandler.splitted;for(let t=0;t<r;++t){for(let s=0;s<a;++s)if(e.get(s)){const e=l[s][this.startPosition+t]||this.unitsHandler.defaultGapSymbol,n=this.positions[t],r=n.getFreq(e);++n.sumRowCount,r.value=++r.rowCount}if(this.valueAggrType===i.AGG.TOTAL_COUNT)continue;let s=null;try{s=this.dataFrame.getCol(this.valueColumnName),s.matches("numerical")||(s=null)}catch{s=null}if(s){for(let n=0;n<a;++n)if(e.get(n)){const e=l[n][this.startPosition+t]||this.unitsHandler.defaultGapSymbol,r=s.get(n);this.positions[t].getFreq(e).push(r)}this.positions[t].aggregate(this.valueAggrType)}}const h=this.valueAggrType===i.AGG.TOTAL_COUNT?0:Math.min(0,Math.min(...this.positions.map((e=>e.getMinValue()))));for(let e=0;e<r;++e)this.positions[e].calcPlotValue(h),this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(t),-1===this.startPosition)return;const r=Math.max(Math.floor(this.slider.min),0),o=Math.min(this.positions.length-1,Math.floor(this.slider.max));e>=_.Layout&&((e,t,s,r)=>{v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const o=this.canvas.height-r*s;let a;if(this.valueAggrType===i.AGG.TOTAL_COUNT){const e=this.getAlphabetSize();this.positionHeight==m.ES.Entropy&&null==e&&n.shell.error("WebLogo: alphabet is undefined."),a=Math.log2(e)}else a=Math.max(...c().count(e).takeWhile((e=>e<=t)).map((e=>this.positions[e].sumPlotValueForHeight)));for(let n=e;n<=t;++n)n in this.positions?this.positions[n].calcScreen((e=>this.unitsHandler.isGap(e)),n,this.slider.min,o,this.positionHeight,a,this._positionWidthWithMargin,this._positionWidth,s,r):v._package.logger.warning(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${n}`);v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(r,o,window.devicePixelRatio,s);const a=this.canvas.getContext("2d");if(a){a.save();try{this.Length,a.resetTransform(),a.fillStyle=function(e){const t=i.Color.a(e);return`#${(16777215&e).toString(16).padStart(6,"0")}`+t.toString(16).padStart(2,"0")}(this.backgroundColor),a.fillRect(0,0,this.canvas.width,this.canvas.height),a.textBaseline=this.textBaseline;const e=10*t;a.resetTransform(),a.fillStyle="black",a.textAlign="center",a.font=`${e.toFixed(1)}px Roboto, Roboto Local, sans-serif`,s>0&&this.positions.length>0&&function(e,t,s,n,r,i,o,a){e.save();try{e.textAlign="center";let l=null,c=null;for(let t=Math.floor(o);t<=Math.floor(a);t++){const s=i[t],n=e.measureText(s.name),r=n.actualBoundingBoxDescent-n.actualBoundingBoxAscent;l=null===l?n.width:Math.max(l,n.width),c=null===c?r:Math.max(c,r)}const h=l<n*t-2?1:(n*t-2)/l;for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=i[l],u=(l-o)*s*t+n*t/2,d=(r*t-c)/2;e.setTransform(h,0,0,1,u,d),e.measureText(a.label),e.fillText(a.label,0,0)}}finally{e.restore()}}(a,t,this._positionWidthWithMargin,this._positionWidth,s,this.positions,this.slider.min,this.slider.max);const n="16px Roboto, Roboto Local, sans-serif",l=.25,c=12.2;for(let e=r;e<=o;e++)this.positions[e].render(a,(e=>this.unitsHandler.isGap(e)),n,l,c,this.palette)}finally{a.restore()}v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${e} ), end`)}}renderRequestOnDebounce(e){const t=`${this.viewerToLog()}.renderRequestOnDebounce()`;"HTML"!==a()(this.root).offsetParent().get()[0]?.tagName?(this.requestedRenderLevel=_.None,this.renderInt(e).catch((e=>{const[t,s]=(0,f.yf)(e);v._package.logger.error(t,void 0,s)}))):v._package.logger.warning(`${t}, $(this.root).offsetParent() is the 'HTML' tag.`)}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(e){try{const e={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(e)} ), start`),this.render(_.Layout,"sliderOnValuesChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+t)}}dataFrameFilterOnChanged(e){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.filterSource===m.Ct.Filtered&&this.render(_.Freqs,"dataFrameFilterOnChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+t)}}dataFrameSelectionOnChanged(e){v._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===m.Ct.Selected&&this.render(_.Freqs,"dataFrameSelectionOnChanged")}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+t)}}canvasOnMouseMove(e){const t=window.devicePixelRatio;try{const s=e,n=this.canvas.getCursorPosition(s,t),[o,a]=this.getMonomer(n,t),l=this.showPositionLabels?12*t:0;if(null!==o&&null===a&&0<=n.y&&n.y<=l){const e=[r.divText(`Position ${o.label}`)];this.valueAggrType===i.AGG.TOTAL_COUNT&&e.push(o.buildCompositionTable(this.palette));const t=r.divV(e);r.tooltip.show(t,s.x+16,s.y+16)}else if(null!==o&&a&&this.dataFrame&&this.seqCol&&this.unitsHandler){const e=o.getFreq(a),t=[r.div(`${a}`),r.div(`${e.rowCount} rows`)];this.valueAggrType!==i.AGG.TOTAL_COUNT&&t.push(r.div(`${this.valueAggrType}: ${e.value.toFixed(3)}`));const n=r.divV(t);r.tooltip.show(n,s.x+16,s.y+16)}else r.tooltip.hide()}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+t)}}canvasOnMouseDown(e){try{const t=e,s=window.devicePixelRatio,[n,r]=this.getMonomer(this.canvas.getCursorPosition(t,s),s);if(null!==n&&null!==r&&this.dataFrame&&this.seqCol&&this.unitsHandler){const e=i.BitSet.create(this.dataFrame.selection.length,(e=>function(e,t,s,n,r,i){const o=t.splitted[n],a=i.pos<o.length?o[i.pos]:null;return a===r||""===a&&r===t.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.getFilter(),e,r,n)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+t)}}canvasOnWheel(e){const t=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*t),n=e.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+n)}catch(e){const t=p(e);v._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+t)}}get onRendered(){return this._onRendered}invalidate(e){const t=`invalidate(${e?` <- ${e} `:""})`,s=`${this.viewerToLog()}.${t}`;this.viewSyncer.sync(`${s}`,(async()=>{this.render(_.None,t),this._onRendered.next()}))}async awaitRendered(e=5e3){await(0,g.zg)(this.onRendered,(()=>{}),(()=>{this.invalidate()}),e);const t=this.viewSyncer.resetErrors();if(t.length>0)throw t[0]}}function $(e,t,s,n,r){let i=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const e=t.splitted[o],s=r.pos;(s<e.length?e[s]:null)===n&&i++}return i}P.residuesSet="nucleotides",P.viewerCounter=-1},8755:(e,t,s)=>{"use strict";s.d(t,{Y:()=>o,x:()=>i});var n=s(701),r=s(3348);class i{get onChanged(){return this._onChanged}constructor(e){return this.substructure=e,this._onChanged=new n.Subject,new Proxy(this,{set:(e,t,s)=>(r._package.logger.debug(`BioFilterProps.set ${t.toString()}( '${s}' )`),e[t]=s,this._onChanged.next(),!0)})}save(){const e={};for(const[t,s]of Object.entries(this))"_onChanged"!==t&&(e[t]=this[t]);return e}apply(e){for(const[t,s]of Object.entries(this))"_onChanged"!==t&&(this[t]=e[t])}}class o{constructor(){this.onChanged=new n.Subject,this._propsChanging=!1,this._propsOnChangedSub=null}get props(){return this._props||(this._props=this.emptyProps),this._props}set props(e){this._propsChanging=!0;try{this._propsOnChangedSub&&(this._propsOnChangedSub.unsubscribe(),this._propsOnChangedSub=null),this._props=e,this.applyProps(),this.onChanged.next(),this._propsOnChangedSub=this._props.onChanged.subscribe((()=>{this.onChanged.next()}))}finally{this._propsChanging=!1}}async detach(){this._propsOnChangedSub&&(this._propsOnChangedSub.unsubscribe(),this._propsOnChangedSub=null)}get filterSummary(){return this.props.substructure}get isFiltering(){return""!==this.props.substructure}resetFilter(){this.props=this.emptyProps,this.onChanged.next()}}},5393:(e,t,s)=>{"use strict";s.d(t,{ST:()=>S,LH:()=>A});var n=s(3870),r=s(976),i=s(4469),o=s(6414),a=s.n(o),l=s(701),c=s(8447),h=s(8467),u=s(499),d=s(172),m=s(7983),p=s(8755),f=s(3336),g=s.n(f),y=s(7945),b=s(4293),w=s(3348);class C extends p.Y{viewerToLog(){return`HelmBioFilter<${this.viewerId}>`}get type(){return"HelmBioFilter"}constructor(){super(),this.emptyProps=new p.x(""),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.viewerId=++C.viewerCounter,this.viewSubs=[],this.logger=w._package.logger}async detach(){await super.detach();for(const e of this.viewSubs)e.unsubscribe()}async attach(){this.viewerToLog();try{const e=await async function(){const e="Helm",t=r.Func.find({package:e,name:"getHelmHelper"});if(0===t.length)throw new Error(`Package '${e}' must be installed for HelmHelper.`);return(await t[0].prepare().call()).getOutputParamValue()}();let t,s;this.helmEditor=e.createHelmWebEditor(),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom waiting..."),await n.tools.waitForElementInDom(this._filterPanel),this.logger.warning("TEST: HelmBioFilter.init().sync() waitForElementInDom ready"),this.updateFilterPanel(),this.viewSubs.push((0,l.fromEvent)(this._filterPanel,"click").subscribe((()=>{t=n.div(),s=e.createWebEditorApp(t,this.props.substructure),n.dialog({showHeader:!1,showFooter:!0}).add(t).onOK((()=>{try{const e=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.props=new p.x(e)}catch(e){this.logger.error(e)}finally{g()(t).empty(),t=null,s=null}})).onCancel((()=>{g()(t).empty(),t=null,s=null})).show({modal:!0,fullScreen:!0})}))),this.viewSubs.push(n.onSizeChanged(this._filterPanel).subscribe((e=>{try{if(s){const e=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}}catch(e){const[t,s]=(0,y.yf)(e);this.logger.error(t,void 0,s)}})))}catch(e){const[t,s]=(0,y.yf)(e),r=this._filterPanel;r.innerText="error",r.classList.add("d4-error"),n.tooltip.bind(r,t)}}applyProps(){this.helmEditor&&this.updateFilterPanel(this.props.substructure)}get filterPanel(){return this._filterPanel}updateFilterPanel(e){if(!this.helmEditor)throw new Error("helmEditor is not created, the filter is not in dom yet");const t=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=t/2;if(e)(0,b.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(e),this.helmEditor.resizeEditor(t,s);else{const e=n.divText("Click to edit","helm-substructure-filter");(0,b.Y)(this._filterPanel,e)}}async substructureSearch(e){return await(0,h.gw)(10),await(0,m.QF)(this.props.substructure,e)}}C.viewerCounter=-1;const v="bio-substructure-filter";class T{constructor(e,t,s,n,r){this.props=e,this.filterId=t,this.dataFrameId=s,this.columnName=n,this.bitset=r}}class A extends p.x{constructor(e,t){super(e),this.separator=t}}class S extends r.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(e){this.loader.style.display=e?"initial":"none"}get filterSummary(){return this.bioFilter.filterSummary}get isFiltering(){return super.isFiltering&&(this.bioFilter?.isFiltering??!1)}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get debounceTime(){if(null==this.column)return 1e3;const e=this.column.length;return e<500?0:e>1e4?1e3:Math.floor((e-500)/9500*1e3)}constructor(){return super(),this.bioFilter=null,this.bitset=null,this.notation=void 0,this.filterId=++S.filterCounter,this.viewSubs=[],this._onRendered=new l.Subject,this.root=n.divV([]),this.loader=n.loader(),this.calculating=!1,this.filterSyncer=new d.c(this.logger=w._package.logger),new Proxy(this,{set:(e,t,s)=>(e[t]=s,!0)})}filterToLog(){return`BioSubstructureFilter<${this.filterId}>`}attach(e){const t=super.attach.bind(this),s=`${this.filterToLog()}.attach()`;this.filterSyncer.sync(s,(async()=>{t(e),this.column=e.columns.bySemType(r.SEMTYPE.MACROMOLECULE),u.Cn.getOrCreate(this.column),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(r.TAGS.UNITS)),this.bioFilter=this.notation===c.r2.FASTA?new _:this.notation===c.r2.SEPARATOR?new E(this.column.getTag("separator")):new C,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),await this.bioFilter.attach(),this.viewSubs.push(r.debounce(this.bioFilter.onChanged,this.debounceTime).subscribe(this.bioFilterOnChangedDebounced.bind(this))),this.viewSubs.push(i.events.onResetFilterRequest.subscribe((e=>{this.bioFilter?.resetFilter()}))),this.viewSubs.push(i.events.onCustomEvent(v).subscribe(this.filterOnSync.bind(this)))}))}detach(){const e=super.detach.bind(this),t=`${this.filterToLog()}.detach()`;this.filterSyncer.sync(t,(async()=>{for(const e of this.viewSubs)e.unsubscribe();this.viewSubs=[],e(),this.bioFilter&&this.bioFilter.detach(),this.bioFilter=null}))}filterOnSync(e){e.filterId!==this.filterId&&e.dataFrameId===this.dataFrame.id&&e.columnName===this.columnName&&(this.bioFilter.props=e.props)}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const e=super.saveState();return e.props=this.bioFilter.props.save(),e}applyState(e){super.applyState(e),e.props&&this.bioFilter.props.apply(e.props)}fireFilterSync(){const e=`${this.filterToLog()}.fireFilterSync()`;w._package.logger.debug(`${e}, bioFilter = ${this.bioFilter?this.bioFilter.constructor.name:"null"}`+(this.bioFilter?`, props = ${JSON.stringify(this.bioFilter.props.save())}`:"")),i.events.fireCustomEvent(v,new T(this.bioFilter.props,this.filterId,this.dataFrame.id,this.columnName,this.bitset))}bioFilterOnChangedDebounced(){if(!this.dataFrame)return;const e=`${this.filterToLog()}.bioFilterOnChangedDebounced()`;if(w._package.logger.debug(`${e}, start, isFiltering = ${this.isFiltering}, props = ${JSON.stringify(this.bioFilter.props.save())}`),!this.isFiltering)return this.bitset=null,void this.dataFrame.rows.requestFilter();a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`)||this.filterSyncer.sync(e,(async()=>{this.calculating=!0;try{w._package.logger.debug(`${e}, before substructureSearch`),this.bitset=await(this.bioFilter?.substructureSearch(this.column)),w._package.logger.debug(`${e}, after substructureSearch`),this.calculating=!1,this.fireFilterSync(),this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1,w._package.logger.debug(`${e}, end`)}}))}get onRendered(){return this._onRendered}invalidate(e){const t=`${this.filterToLog()}.invalidate(${e?` <- ${e} `:""})`;this.filterSyncer.sync(t,(async()=>{this._onRendered.next()}))}async awaitRendered(e=1e4){const t=`awaitRendered( ${e} 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s={splitter:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num-MON8-N9\nid3,mon1-M-mon3-mon4-mon5-MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:6},tgt:{pos:0}},{src:{row:1,x:26},tgt:{pos:1}},{src:{row:1,x:160},tgt:{pos:6}},{src:{row:1,x:185},tgt:{pos:7}},{src:{row:2,x:140},tgt:{pos:5}},{src:{row:2,x:145},tgt:{pos:5}}]},splitterMsa:{csv:"id,seq\nid1,m1-M-m3-mon4-mon5-N-T-MON8-N9\nid2,m1-mon2-m3-mon4-mon5-Num--MON8-N9\nid3,\nid4,mon1-M-mon3-mon4-mon5---MON8-N9\n",testList:[{src:{row:0,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:4},tgt:{pos:null}},{src:{row:1,x:5},tgt:{pos:0}},{src:{row:1,x:37},tgt:{pos:0}},{src:{row:1,x:38},tgt:{pos:1}},{src:{row:1,x:170},tgt:{pos:4}},{src:{row:1,x:200},tgt:{pos:5}},{src:{row:2,x:20},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:4}},{src:{row:3,x:200},tgt:{pos:5}},{src:{row:3,x:282},tgt:{pos:null}}]},fastaMsa:{csv:"id,seq\nid1,QQYNIYPLT\nid2,QQWSSFPYT\nid3,\nid3,QHIRE--LT\n",testList:[{src:{row:1,x:-1},tgt:{pos:null}},{src:{row:1,x:0},tgt:{pos:null}},{src:{row:1,x:1},tgt:{pos:null}},{src:{row:1,x:19},tgt:{pos:0}},{src:{row:1,x:170},tgt:{pos:8}},{src:{row:1,x:171},tgt:{pos:8}},{src:{row:2,x:5},tgt:{pos:null}},{src:{row:3,x:170},tgt:{pos:8}},{src:{row:3,x:181},tgt:{pos:null}}]}};for(const[n,r]of Object.entries(s))(0,t.Bu)(`getPosition-${n}`,(async()=>{const t=e.DataFrame.fromCsv(r.csv);await a.data.detectSemanticTypes(t);const s=t.getCol("seq"),n=new D.A(null,s,(()=>({unitsHandler:h.Cn.getOrCreate(s),monomerCharWidth:7,separatorWidth:12,monomerToShort:c.GU,monomerLengthLimit:3}))),i=r.testList;for(let e=0;e<s.length;++e)n.getCellMonomerLengths(e);const o=[];for(const[e,t]of F().enumerate(i)){const t={pos:n.getPosition(e.src.row,e.src.x)};e.tgt.pos!=t.pos&&o.push(`Test src ${JSON.stringify(e.src)} expected tgt ${JSON.stringify(e.tgt)}, but get ${JSON.stringify({res:t})}`)}if(o.length>0)throw new Error("Test failed error(s):\n"+o.join(", n"))}))})),(0,t.W3)("converters",(()=>{let s;!function(e){e.fastaPt="fastaPt",e.separatorPt="separatorPt",e.helmPt="helmPt",e.fastaDna="fastaDna",e.separatorDna="separatorDna",e.helmDna="helmDna",e.fastaRna="fastaRna",e.separatorRna="separatorRna",e.helmRna="helmRna",e.fastaGaps="fastaGaps",e.separatorGaps="separatorGaps",e.helmGaps="helmGaps",e.fastaUn="fastaUn",e.separatorUn="separatorUn",e.helmUn="helmUn",e.helmLoneDeoxyribose="helmLoneDeoxyribose",e.helmLoneRibose="helmLoneRibose",e.helmLonePhosphorus="helmLonePhosphorus",e.fastaLoneDeoxyribose="fastaLoneDeoxyribose",e.fastaLoneRibose="fastaLoneRibose",e.fastaLonePhosphorus="fastaLonePhosphorus"}(s||(s={}));const n={[s.fastaPt]:"seq\nFWPHEYFWPHEY\nYNRQWYVYNRQWYV\nMKPSEYVMKPSEYV",[s.separatorPt]:"seq\nF-W-P-H-E-Y-F-W-P-H-E-Y\nY-N-R-Q-W-Y-V-Y-N-R-Q-W-Y-V\nM-K-P-S-E-Y-V-M-K-P-S-E-Y-V",[s.helmPt]:"seq\nPEPTIDE1{F.W.P.H.E.Y.F.W.P.H.E.Y}$$$$\nPEPTIDE1{Y.N.R.Q.W.Y.V.Y.N.R.Q.W.Y.V}$$$$\nPEPTIDE1{M.K.P.S.E.Y.V.M.K.P.S.E.Y.V}$$$$",[s.fastaDna]:"seq\nACGTCACGTC\nCAGTGTCAGTGT\nTTCAACTTCAAC",[s.separatorDna]:"seq\nA/C/G/T/C/A/C/G/T/C\nC/A/G/T/G/T/C/A/G/T/G/T\nT/T/C/A/A/C/T/T/C/A/A/C",[s.helmDna]:"seq\nRNA1{d(A)p.d(C)p.d(G)p.d(T)p.d(C)p.d(A)p.d(C)p.d(G)p.d(T)p.d(C)p}$$$$\nRNA1{d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p.d(C)p.d(A)p.d(G)p.d(T)p.d(G)p.d(T)p}$$$$\nRNA1{d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p.d(T)p.d(T)p.d(C)p.d(A)p.d(A)p.d(C)p}$$$$",[s.fastaRna]:"seq\nACGUCACGUC\nCAGUGUCAGUGU\nUUCAACUUCAAC",[s.separatorRna]:"seq\nA*C*G*U*C*A*C*G*U*C\nC*A*G*U*G*U*C*A*G*U*G*U\nU*U*C*A*A*C*U*U*C*A*A*C",[s.helmRna]:"seq\nRNA1{r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p}$$$$",[s.fastaGaps]:"seq\nFW-PH-EYYFW-PH-EYY\nFYNRQWYV-FYNRQWYV-\nFKP-Q-SEYVFKP-Q-SEYV",[s.separatorGaps]:"seq\nF/W//P/H//E/Y/Y/F/W//P/H//E/Y/Y\nF/Y/N/R/Q/W/Y/V//F/Y/N/R/Q/W/Y/V/\nF/K/P//Q//S/E/Y/V/F/K/P//Q//S/E/Y/V",[s.helmGaps]:"seq\nPEPTIDE1{F.W.*.P.H.*.E.Y.Y.F.W.*.P.H.*.E.Y.Y}$$$$\nPEPTIDE1{F.Y.N.R.Q.W.Y.V.*.F.Y.N.R.Q.W.Y.V.*}$$$$\nPEPTIDE1{F.K.P.*.Q.*.S.E.Y.V.F.K.P.*.Q.*.S.E.Y.V}$$$$",[s.fastaUn]:"seq\n[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D[meI][hHis][Aca]NT[dE][Thr_PO3H2][Aca]D\n[meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][meI][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2]\n[Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca][Tyr_PO3H2][Lys_Boc][hHis][Aca][Cys_SEt]T[dK][Thr_PO3H2][Aca]",[s.separatorUn]:"seq\nmeI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D-meI-hHis-Aca-N-T-dE-Thr_PO3H2-Aca-D\nmeI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-meI-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2\nLys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca-Tyr_PO3H2-Lys_Boc-hHis-Aca-Cys_SEt-T-dK-Thr_PO3H2-Aca",[s.helmUn]:"seq\nPEPTIDE1{meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D.meI.hHis.Aca.N.T.dE.Thr_PO3H2.Aca.D}$$$$\nPEPTIDE1{meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.meI.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2}$$$$\nPEPTIDE1{Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca.Tyr_PO3H2.Lys_Boc.hHis.Aca.Cys_SEt.T.dK.Thr_PO3H2.Aca}$$$$",[s.helmLoneDeoxyribose]:"seq\nRNA1{d(A).d(C).d(G).d(T).d(C).d(A).d(C).d(G).d(T).d(C)}$$$$\nRNA1{d(C).d(A).d(G).d(T).d(G).d(T)p.d(C).d(A).d(G).d(T).d(G).d(T)p}$$$$\nRNA1{d(T).d(T).d(C).d(A).d(A).d(C)p.d(T).d(T).d(C).d(A).d(A).d(C)p}$$$$",[s.helmLoneRibose]:"seq\nRNA1{r(A).r(C).r(G).r(U).r(C).r(A).r(C).r(G).r(U).r(C)}$$$$\nRNA1{r(C).r(A).r(G).r(U).r(G).r(U)p.r(C).r(A).r(G).r(U).r(G).r(U)p}$$$$\nRNA1{r(U).r(U).r(C).r(A).r(A).r(C)p.r(U).r(U).r(C).r(A).r(A).r(C)p}$$$$",[s.helmLonePhosphorus]:"seq\nRNA1{p.p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p.r(A)p.r(C)p.r(G)p.r(U)p.r(C)p}$$$$\nRNA1{p.p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p.r(C)p.r(A)p.p.r(G)p.r(U)p.r(G)p.r(U)p}$$$$\nRNA1{p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.r(U)p.r(U)p.r(C)p.r(A)p.r(A)p.r(C)p.p.p}$$$$"};async 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function m(t){const s=d[t],n=e.DataFrame.fromCsv(s.replace(/\n$/,""));return await a.data.detectSemanticTypes(n),n}(0,t.Bu)("fastaDna",(async()=>{await oe(await m(o.fastaDna),"seq",r)})),(0,t.Bu)("fastaRna",(async()=>{await oe(await m(o.fastaRna),"seq",r)})),(0,t.Bu)("fastaPt",(async()=>{await oe(await m(o.fastaPt),"seq",r)})),(0,t.Bu)("separatorDna",(async()=>{await oe(await m(o.separatorDna),"seq",r)})),(0,t.Bu)("separatorDna",(async()=>{await oe(await m(o.separatorRna),"seq",r)})),(0,t.Bu)("separatorPt",(async()=>{await oe(await m(o.separatorPt),"seq",r)})),(0,t.Bu)("separatorUn",(async()=>{await oe(await m(o.separatorUn),"seq",r)})),(0,t.Bu)("helm",(async()=>{await oe(await m(o.helm),"seq",r)})),(0,t.Bu)("ptFasta2",(async()=>{const s=await ge.files.readAsText("tests/to-atomic-level-pt-fasta-2.mol"),n=e.DataFrame.fromCsv("seq\nAR"),i=n.getCol("seq");i.semType=e.SEMTYPE.MACROMOLECULE,i.setTag(e.TAGS.UNITS,c.r2.FASTA),i.setTag("alphabet","PT"),h.Cn.getOrCreate(i);const o=await oe(n,"seq",r);(0,t.l_)(ae(o.get(0)),ae(s))}))}));var le=s(708);async function ce(t){const s=e.DataFrame.fromCsv(t),n=s.col("seq"),r=await a.functions.call("Bio:detectMacromolecule",{col:n});return r&&(n.semType=r),await a.data.detectSemanticTypes(s),h.Cn.getOrCreate(n)}function he(e,s,n,r){const i=n(e,s);(0,t.l_)(Number(i.toFixed(3)),Number(r.toFixed(3)))}(0,t.W3)("Distance",(async()=>{const s=[[1,0,0,0],[0,1,0,0],[0,0,1,0],[0,0,0,1]],n={F:0,W:1,R:2,Y:3},r="FWRWY",i="FWRWW",o="FWY",a="FWRWY",l="FWY",c="FWRRRRY";(0,t.Bu)("protein-distance-function",(async()=>{const e=(await ce("seq\nFWRWYVKHPFWRWYVKHP\nYNRWYVKHPYNRWYVKHP\nMWRSWYCKHPMWRSWYCKHP")).getDistanceFunctionName();(0,t.l_)(e,le.U.LEVENSHTEIN)})),(0,t.Bu)("DNA-distance-function",(async()=>{const e=(await ce("seq\nATAACGATAACG\nATCGAATCGA\nATCGAATCGA")).getDistanceFunctionName();(0,t.l_)(e,le.U.LEVENSHTEIN)})),(0,t.Bu)("MSA-distance-function",(async()=>{const e=(await 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