@datagrok/bio 2.11.11 → 2.11.14

package/src/tests/pepsea-tests.ts

@@ -16,7 +16,7 @@ category('PepSeA', () => {
     await awaitContainerStart();
     const table = DG.DataFrame.fromCsv(testCsv);
     const alignedCol = await runPepsea(table.getCol('HELM'), 'msa(HELM)');
-    expect(alignedCol !== null, true, 'PepSeA conainter has not started');
+    expect(alignedCol !== null, true, 'PepSeA container has not started');
     const alignedTestCol = table.getCol('MSA');
     for (let i = 0; i < alignedCol!.length; ++i)
       expect(alignedCol!.get(i) == alignedTestCol.get(i), true);

package/src/tests/sequence-space-utils.ts

@@ -1,9 +1,10 @@
 import * as DG from 'datagrok-api/dg';
 import * as grok from 'datagrok-api/grok';
 import {expect} from '@datagrok-libraries/utils/src/test';
-import {BYPASS_LARGE_DATA_WARNING, sequenceSpaceTopMenu} from '../package';
+import {sequenceSpaceTopMenu} from '../package';
 import {MmDistanceFunctionsNames} from '@datagrok-libraries/ml/src/macromolecule-distance-functions';
 import {DimReductionMethods} from '@datagrok-libraries/ml/src/reduce-dimensionality';
+import {BYPASS_LARGE_DATA_WARNING} from '@datagrok-libraries/ml/src/functionEditors/consts';
 
 export async function _testSequenceSpaceReturnsResult(
   df: DG.DataFrame, algorithm: DimReductionMethods, colName: string,
@@ -14,7 +15,10 @@ export async function _testSequenceSpaceReturnsResult(
   if (semType)
     col.semType = semType;
 
+  const preprocessingFunc = DG.Func.find({package: 'Bio', name: 'macromoleculePreprocessingFunction'})[0];
+  if (!preprocessingFunc)
+    throw new Error('Preprocessing function not found');
   const sp = await sequenceSpaceTopMenu(df, df.col(colName)!, algorithm, MmDistanceFunctionsNames.LEVENSHTEIN, true,
-    0.6, {[`${BYPASS_LARGE_DATA_WARNING}`]: true});
+    preprocessingFunc, {[BYPASS_LARGE_DATA_WARNING]: true});
   expect(sp != null, true);
 }

package/src/tests/similarity-diversity-tests.ts

@@ -1,10 +1,12 @@
-import {category, test, expect, awaitCheck, delay} from '@datagrok-libraries/utils/src/test';
 import * as DG from 'datagrok-api/dg';
-import {createTableView} from './utils';
 import * as grok from 'datagrok-api/grok';
+
+import {category, test, expect, awaitCheck, delay} from '@datagrok-libraries/utils/src/test';
 import {SequenceSimilarityViewer} from '../analysis/sequence-similarity-viewer';
 import {SequenceDiversityViewer} from '../analysis/sequence-diversity-viewer';
 
+import {_package} from '../package-test';
+
 category('similarity/diversity', async () => {
   test('similaritySearchViewer', async () => {
     await _testSimilaritySearchViewer();
@@ -16,7 +18,12 @@ category('similarity/diversity', async () => {
 });
 
 async function _testSimilaritySearchViewer() {
-  const moleculesView = await createTableView('tests/sample_MSA_data.csv');
+  const csv = await _package.files.readAsText('tests/sample_MSA_data.csv');
+  const df = DG.DataFrame.fromCsv(csv);
+  await grok.data.detectSemanticTypes(df);
+  const moleculesView = grok.shell.addTableView(df);
+  const seqCol = moleculesView.dataFrame.getCol('MSA');
+  expect(seqCol.semType, DG.SEMTYPE.MACROMOLECULE);
 
   const viewer: SequenceSimilarityViewer = (await moleculesView.dataFrame.plot
     .fromType('Sequence Similarity Search')) as SequenceSimilarityViewer;
@@ -61,7 +68,12 @@ async function _testSimilaritySearchViewer() {
 }
 
 async function _testDiversitySearchViewer() {
-  const moleculesView = await createTableView('tests/sample_MSA_data.csv');
+  const csv = await _package.files.readAsText('tests/sample_MSA_data.csv');
+  const df = DG.DataFrame.fromCsv(csv);
+  const moleculesView = grok.shell.addTableView(df);
+  await grok.data.detectSemanticTypes(df);
+  const seqCol = moleculesView.dataFrame.getCol('MSA');
+  expect(seqCol.semType, DG.SEMTYPE.MACROMOLECULE);
 
   const viewer: SequenceDiversityViewer = (await moleculesView.dataFrame.plot
     .fromType('Sequence Diversity Search')) as SequenceDiversityViewer;

package/src/tests/splitters-test.ts

@@ -21,9 +21,6 @@ import {
   NOTATION
 } from '@datagrok-libraries/bio/src/utils/macromolecule';
 import {splitToMonomersUI} from '../utils/split-to-monomers';
-import {SEMTYPE} from 'datagrok-api/dg';
-import {UnitsHandler} from '@datagrok-libraries/bio/src/utils/units-handler';
-import {TAGS} from '../utils/constants';
 
 
 category('splitters', async () => {

package/src/tests/to-atomic-level-tests.ts

@@ -22,9 +22,9 @@ const appPath = 'System:AppData/Bio';
 const fileSource = new DG.FileSource(appPath);
 
 const testNames: { [k: string]: string } = {
-  PT: 'peptides fasta',
-  DNA: 'dna fasta',
-  MSA: 'msa separator',
+  PT: 'peptides-fasta',
+  DNA: 'dna-fasta',
+  MSA: 'msa-separator',
 };
 
 const inputPath: { [k: string]: string } = {

package/src/utils/cell-renderer.ts

@@ -27,7 +27,7 @@ import * as C from './constants';
 import {_package, getBioLib} from '../package';
 import {ISeqSplitted} from '@datagrok-libraries/bio/src/utils/macromolecule/types';
 import {getSplitter} from '@datagrok-libraries/bio/src/utils/macromolecule/utils';
-import {errInfo} from './err-info';
+import {errInfo} from '@datagrok-libraries/bio/src/utils/err-info';
 
 
 type TempType = { [tagName: string]: any };

package/src/utils/helm-to-molfile.ts

@@ -7,9 +7,9 @@ import {MolfileHandler} from '@datagrok-libraries/chem-meta/src/parsing-utils/mo
 import {MolfileHandlerBase} from '@datagrok-libraries/chem-meta/src/parsing-utils/molfile-handler-base';
 import {RDMol, RDModule} from '@datagrok-libraries/chem-meta/src/rdkit-api';
 import {HELM_POLYMER_TYPE, HELM_RGROUP_FIELDS} from '@datagrok-libraries/bio/src/utils/const';
+import {errInfo} from '@datagrok-libraries/bio/src/utils/err-info';
 
 import {MonomerLibHelper} from './monomer-lib';
-import {errInfo} from './err-info';
 
 import {_package} from '../package';
 

package/src/utils/monomer-lib.ts

@@ -42,7 +42,7 @@ export async function manageFiles() {
 export async function getLibraryPanelUI(): Promise<DG.Widget> {
   //@ts-ignore
   const filesButton: HTMLButtonElement = ui.button('Manage', manageFiles);
-  const inputsForm: HTMLDivElement = ui.inputs([]);
+  const inputsForm: HTMLElement = ui.inputs([]);
   const libFileNameList: string[] = await getLibFileNameList();
 
   const settings = await getUserLibSettings();

package/src/utils/pepsea.ts

@@ -1,9 +1,24 @@
 /* Do not change these import lines to match external modules in webpack configuration */
 import * as grok from 'datagrok-api/grok';
 import * as DG from 'datagrok-api/dg';
+
+import {Subject} from 'rxjs';
+
+import {testEvent} from '@datagrok-libraries/utils/src/test';
 import {NOTATION, TAGS as bioTAGS, ALIGNMENT, ALPHABET} from '@datagrok-libraries/bio/src/utils/macromolecule';
+
 import * as C from './constants';
 
+import {_package} from '../package';
+
+export const Pepsea = new class {
+  public readonly dcName: string = 'bio';
+
+  public async getDockerContainer(): Promise<DG.DockerContainer> {
+    return await grok.dapi.docker.dockerContainers.filter(this.dcName).first();
+  }
+}();
+
 export const pepseaMethods = ['mafft --auto', 'mafft', 'linsi', 'ginsi', 'einsi', 'fftns', 'fftnsi', 'nwns', 'nwnsi'];
 const alignmentObjectMetaKeys = ['AlignedSeq', 'AlignedSubpeptide', 'HELM', 'ID', 'PolymerID'];
 type PepseaResponse = {
@@ -28,7 +43,7 @@ export async function runPepsea(srcCol: DG.Column<string>, unUsedName: string,
   method: typeof pepseaMethods[number] = 'ginsi', gapOpen: number = 1.53, gapExtend: number = 0.0,
   clustersCol: DG.Column<string | number> | null = null,
 ): Promise<DG.Column<string> | null> {
-  const pepseaContainer = await grok.dapi.docker.dockerContainers.filter('bio').first();
+  const pepseaContainer = await Pepsea.getDockerContainer();
   if (pepseaContainer.status !== 'started' && pepseaContainer.status !== 'checking') {
     grok.log.warning('PepSeA container has not started yet');
     return null;

package/src/viewers/vd-regions-viewer.ts

@@ -2,17 +2,20 @@ import * as ui from 'datagrok-api/ui';
 import * as grok from 'datagrok-api/grok';
 import * as DG from 'datagrok-api/dg';
 
-import {fromEvent, Unsubscribable} from 'rxjs';
+import {fromEvent, Observable, Subject, Unsubscribable} from 'rxjs';
 
+import {testEvent} from '@datagrok-libraries/utils/src/test';
 import {
   IVdRegionsViewer,
   VdRegion, VdRegionType,
   VdRegionsProps, VdRegionsPropsDefault,
 } from '@datagrok-libraries/bio/src/viewers/vd-regions';
+import {PromiseSyncer} from '@datagrok-libraries/bio/src/utils/syncer';
 import {FilterSources, IWebLogoViewer, PositionHeight} from '@datagrok-libraries/bio/src/viewers/web-logo';
+import {errInfo} from '@datagrok-libraries/bio/src/utils/err-info';
+
 
 import {WebLogoViewer, PROPS as wlPROPS} from '../viewers/web-logo-viewer';
-import {errInfo} from '../utils/err-info';
 
 import {_package} from '../package';
 
@@ -121,8 +124,15 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
     // -- Behavior --
     this.filterSource = this.string(PROPS.filterSource, defaults.filterSource,
       {category: PROPS_CATS.BEHAVIOR, choices: Object.values(FilterSources)}) as FilterSources;
+
+    this.viewSyncer = new PromiseSyncer(_package.logger);
   }
 
+  private static viewerCounter: number = -1;
+  private readonly viewerId: number = ++VdRegionsViewer.viewerCounter;
+
+  private viewerToLog(): string { return `VdRegionsViewer<${this.viewerId}>`; }
+
   public async init() {
     //#region regionsDF with filter
     // this.regionsDf = DG.DataFrame.fromObjects(this.regions);
@@ -153,19 +163,16 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
   }
 
   override detach() {
+    const logPrefix = `${this.viewerToLog()}.detach()`;
     const superDetach = super.detach.bind(this);
-    this.viewPromise = this.viewPromise.then(async () => { // detach
+    this.viewSyncer.sync(`${logPrefix}`, async () => { // detach
       if (this.setDataInProgress) return; // check setDataInProgress synced
       if (this.viewed) {
         await this.destroyView('detach');
         this.viewed = false;
       }
       superDetach();
-    })
-      .catch((err: any) => {
-        const [errMsg, errStack] = errInfo(err);
-        _package.logger.error(errMsg, undefined, errStack);
-      });
+    });
   }
 
   override onTableAttached() {
@@ -228,13 +235,14 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
 
   // TODO: .onTableAttached is not calling on dataFrame set, onPropertyChanged  also not calling
   public setData(regions: VdRegion[]) {
+    const logPrefix = `${this.viewerToLog()}.setData()`;
     // const setDataInId = ++this.setDataInCount;
-    _package.logger.debug('Bio: VdRegionsViewer.setData(), in, ' +
+    _package.logger.debug(`${logPrefix}, in, ` +
       // `viewerId = ${this.viewerId}, setDataInId = ${setDataInId}, ` +
       `regions.length = ${regions.length}`
     );
 
-    this.viewPromise = this.viewPromise.then(async () => { // setData
+    this.viewSyncer.sync(`${logPrefix}`, async () => { // setData
       // _package.logger.debug('Bio: VdRegionsViewer.setData(), in sync, ' +
       //   `viewerId = ${this.viewerId}, setDataInId = ${setDataInId}, ` +
       //   `regions.length = ${regions.length}`);
@@ -261,10 +269,6 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
           await this.buildView('setData');
           this.viewed = true;
         }
-      } catch (err: any) {
-        const [errMsg, errStack] = errInfo(err);
-        grok.shell.error(errMsg);
-        _package.logger.error(errMsg, undefined, errStack);
       } finally {
         // _package.logger.debug('Bio: VdRegionsViewer.setData(), finally, ' +
         //   `viewerId = ${this.viewerId}, setDataInId = ${setDataInId}, ` +
@@ -276,7 +280,7 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
 
   // -- View --
 
-  private viewPromise: Promise<void> = Promise.resolve();
+  private viewSyncer: PromiseSyncer;
   private setDataInProgress: boolean = false;
 
   private host: HTMLElement | null = null;
@@ -328,7 +332,7 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
             positionWidth: this.positionWidth,
             positionHeight: this.positionHeight,
             filterSource: this.filterSource,
-          }) as WebLogoViewer;
+          }) as unknown as WebLogoViewer;
           wl.onSizeChanged.subscribe(() => { this.calcSize(); });
           return [orderI, chain, wl];
         })());
@@ -479,9 +483,10 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
   }
 
   private filterSourceInputOnValueChanged(): void {
+    const logPrefix = `${this.viewerToLog()}.filterSourceInputOnValueChanged()`;
     const filterSourceValue = this.filterSourceInput.value;
     // Using promise to prevent 'Bad state: Cannot fire new event. Controller is already firing an event'
-    this.viewPromise = this.viewPromise.then(() => {
+    this.viewSyncer.sync(`${logPrefix}`, async () => {
       if (this.filterSource !== filterSourceValue) {
         this.props.getProperty(PROPS.filterSource).set(this, filterSourceValue); // to update value in property panel
 
@@ -495,4 +500,25 @@ export class VdRegionsViewer extends DG.JsViewer implements IVdRegionsViewer {
       }
     });
   }
+
+  // -- IRenderer --
+
+  private _onRendered: Subject<void> = new Subject<void>();
+
+  public get onRendered(): Observable<void> { return this._onRendered; }
+
+  public invalidate(): void {
+    const logPrefix = `${this.viewerToLog()}.invalidate()`;
+    // Put the event trigger in the tail of the synced calls queue.
+    this.viewSyncer.sync(`${logPrefix}`, async () => {
+      // update view / render
+      this._onRendered.next();
+    });
+  }
+
+  public async awaitRendered(timeout: number | undefined = 5000): Promise<void> {
+    await testEvent(this.onRendered, () => {}, () => {
+      this.invalidate();
+    }, timeout);
+  }
 }

package/src/viewers/web-logo-viewer.ts

@@ -17,9 +17,11 @@ import {
 import {errorToConsole} from '@datagrok-libraries/utils/src/to-console';
 import {intToHtmlA} from '@datagrok-libraries/utils/src/color';
 import {ISeqSplitted} from '@datagrok-libraries/bio/src/utils/macromolecule/types';
+import {errInfo} from '@datagrok-libraries/bio/src/utils/err-info';
+import {testEvent} from '@datagrok-libraries/utils/src/test';
+import {PromiseSyncer} from '@datagrok-libraries/bio/src/utils/syncer';
 
 import {AggFunc, getAgg} from '../utils/agg';
-import {errInfo} from '../utils/err-info';
 import {buildCompositionTable} from '../widgets/composition-analysis-widget';
 
 import {_package} from '../package';
@@ -295,11 +297,9 @@ const POSITION_LABELS_HEIGHT: number = 12;
 
 export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
   public static residuesSet = 'nucleotides';
-  private static viewerCount: number = 0;
 
   private viewed: boolean = false;
 
-  private readonly viewerId: number = -1;
   private unitsHandler: UnitsHandler | null;
   private initialized: boolean = false;
 
@@ -381,9 +381,6 @@ export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
   constructor() {
     super();
 
-    this.viewerId = WebLogoViewer.viewerCount;
-    WebLogoViewer.viewerCount += 1;
-
     this.textBaseline = 'top';
     this.unitsHandler = null;
 
@@ -449,13 +446,20 @@ export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
     this.canvas.style.width = '100%';
 
     /* this.root.style.background = '#FFEEDD'; */
+    this.viewSyncer = new PromiseSyncer(_package.logger);
   }
 
+  private static viewerCounter: number = -1;
+  private readonly viewerId: number = ++WebLogoViewer.viewerCounter;
+
+  private viewerToLog(): string { return `MolstarViewer<${this.viewerId}>`; }
+
   // -- Data --
 
   setData(): void {
-    _package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.setData(), in`);
-    this.viewPromise = this.viewPromise.then(async () => { // setData
+    const logPrefix = `${this.viewerToLog()}.setData()`;
+    _package.logger.debug(`${logPrefix}, in`);
+    this.viewSyncer.sync(`${logPrefix}`, async () => { // setData
       if (!this.setDataInProgress) this.setDataInProgress = true; else return; // check setDataInProgress synced
       try {
         if (this.viewed) {
@@ -471,19 +475,16 @@ export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
           await this.buildView(); //requests rendering
           this.viewed = true;
         }
-      } catch (err: any) {
-        const [errMsg, errStack] = errInfo(err);
-        grok.shell.error(errMsg);
-        _package.logger.error(errMsg, undefined, errStack);
       } finally {
         this.setDataInProgress = false;
       }
     });
+    _package.logger.debug(`${logPrefix}, out`);
   }
 
   // -- View --
 
-  private viewPromise: Promise<void> = Promise.resolve();
+  private viewSyncer: PromiseSyncer;
   private setDataInProgress: boolean = false;
   private viewSubs: Unsubscribable[] = [];
 
@@ -892,21 +893,19 @@ export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
 
   /** Remove all handlers when table is a detach  */
   public override async detach() {
-    _package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.detach(), `);
+    const logPrefix = `${this.viewerToLog()}.detach()`;
+    _package.logger.debug(`${logPrefix}, in`);
 
     const superDetach = super.detach.bind(this);
-    this.viewPromise = this.viewPromise.then(async () => { // detach
+    this.viewSyncer.sync(`${logPrefix}`, async () => { // detach
       if (this.setDataInProgress) return; // check setDataInProgress synced
       if (this.viewed) {
         await this.destroyView();
         this.viewed = false;
       }
       superDetach();
-    })
-      .catch((err: any) => {
-        const [errMsg, errStack] = errInfo(err);
-        _package.logger.error(errMsg, undefined, errStack);
-      });
+    });
+    _package.logger.debug(`${logPrefix}, out`);
   }
 
   private _onSizeChanged: Subject<void> = new Subject<void>();
@@ -1275,6 +1274,27 @@ export class WebLogoViewer extends DG.JsViewer implements IWebLogoViewer {
       //throw err; // Do not throw to prevent disabling event handler
     }
   }
+
+  // -- IRenderer --
+
+  private _onRendered: Subject<void> = new Subject<void>();
+
+  public get onRendered(): Observable<void> { return this._onRendered; }
+
+  public invalidate(): void {
+    const logPrefix = `${this.viewerToLog()}.invalidate()`;
+    // Put the event trigger in the tail of the synced calls queue.
+    this.viewSyncer.sync(`${logPrefix}`, async () => {
+      this.invalidate();
+      this._onRendered.next();
+    });
+  }
+
+  public async awaitRendered(timeout: number | undefined = 5000): Promise<void> {
+    await testEvent(this.onRendered, () => {}, () => {
+      this.invalidate();
+    }, timeout);
+  }
 }
 
 function renderPositionLabels(g: CanvasRenderingContext2D,

package/dist/1.js

@@ -1,2 +0,0 @@
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const isNil = (x) => x === null || x === undefined;\n//# sourceMappingURL=data:application/json;base64,eyJ2ZXJzaW9uIjozLCJmaWxlIjoidXRpbHMuanMiLCJzb3VyY2VSb290IjoiIiwic291cmNlcyI6WyJ1dGlscy50cyJdLCJuYW1lcyI6W10sIm1hcHBpbmdzIjoiQUFBQSxNQUFNLENBQUMsTUFBTSxLQUFLLEdBQUcsQ0FBQyxDQUFNLEVBQUUsRUFBRSxDQUFDLENBQUMsS0FBSyxJQUFJLElBQUksQ0FBQyxLQUFLLFNBQVMsQ0FBQyIsInNvdXJjZXNDb250ZW50IjpbImV4cG9ydCBjb25zdCBpc05pbCA9ICh4OiBhbnkpID0+IHggPT09IG51bGwgfHwgeCA9PT0gdW5kZWZpbmVkO1xuIl19","export function hamming(args = {}) {\n    function getDistanceF() {\n        if (!args || !args.scoringMatrix || !args.alphabetIndexes)\n            return (a, b) => a === b ? 0 : 1;\n        if (args.scoringMatrix.length !== Object.keys(args.alphabetIndexes).length)\n            throw new Error('Scoring matrix and alphabet indexes should have the same length');\n        const indexes = args.alphabetIndexes;\n        const matrix = args.scoringMatrix;\n        //const matrixMap = new Map<string, Map<string, number>>();\n        //const map2: any = {};\n        const minCharCode = Math.min(...Object.keys(indexes).map(k => k.charCodeAt(0))) + 1;\n        const scorringArray = new Float32Array((matrix.length + minCharCode) * (matrix.length + minCharCode));\n        Object.entries(indexes).forEach(([key, index]) => {\n            //matrixMap.set(key, new Map<string, number>());\n            //map2[key] = {};\n            const matrixRow = matrix[index];\n            Object.entries(indexes).forEach(([key2, index2]) => {\n                //matrixMap.get(key)!.set(key2, matrixRow[index2]);\n                scorringArray[key.charCodeAt(0) * matrix.length + key2.charCodeAt(0)] = matrixRow[index2];\n                //map2[key][key2] = matrixRow[index2];\n            });\n        });\n        return (a, b) => {\n            return scorringArray[a.charCodeAt(0) * matrix.length + b.charCodeAt(0)];\n        };\n    }\n    const distanceF = getDistanceF();\n    const threshold = args?.threshold ?? 0;\n    return (seq1, seq2) => {\n        // hamming distance should only be used with same size strings,\n        // but still, lets add a check and if they are not same length add the difference to the result\n        let diff = 0;\n        const s1l = seq1.length;\n        const s2l = seq2.length;\n        const thresholdLimit = Math.max(s1l, s2l) * (1 - threshold);\n        if (s1l !== s2l)\n            diff = Math.abs(s1l - s2l);\n        let result = 0;\n        for (let i = 0; i < Math.min(s1l, s2l); i++) {\n            if (seq1[i] !== seq2[i]) {\n                result += distanceF(seq1[i], seq2[i]);\n                if (result > thresholdLimit)\n                    return 1;\n            }\n        }\n        result += diff;\n        result /= Math.max(s1l, s2l);\n        return result;\n    };\n}\n//# sourceMappingURL=data:application/json;base64,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","import { distance } from 'fastest-levenshtein';\nexport function levenstein() {\n    return (seq1, seq2) => {\n        return distance(seq1, seq2) / Math.max(seq1.length, seq2.length);\n    };\n}\n//# sourceMappingURL=data:application/json;base64,eyJ2ZXJzaW9uIjozLCJmaWxlIjoibGV2ZW5zdGVpbi5qcyIsInNvdXJjZVJvb3QiOiIiLCJzb3VyY2VzIjpbImxldmVuc3RlaW4udHMiXSwibmFtZXMiOltdLCJtYXBwaW5ncyI6IkFBQUEsT0FBTyxFQUFDLFFBQVEsRUFBQyxNQUFNLHFCQUFxQixDQUFDO0FBRzdDLE1BQU0sVUFBVSxVQUFVO0lBQ3hCLE9BQU8sQ0FBQyxJQUFZLEVBQUUsSUFBWSxFQUFFLEVBQUU7UUFDcEMsT0FBTyxRQUFRLENBQUMsSUFBSSxFQUFFLElBQUksQ0FBQyxHQUFHLElBQUksQ0FBQyxHQUFHLENBQUMsSUFBSSxDQUFDLE1BQU0sRUFBRSxJQUFJLENBQUMsTUFBTSxDQUFDLENBQUM7SUFDbkUsQ0FBQyxDQUFDO0FBQ0osQ0FBQyIsInNvdXJjZXNDb250ZW50IjpbImltcG9ydCB7ZGlzdGFuY2V9IGZyb20gJ2Zhc3Rlc3QtbGV2ZW5zaHRlaW4nO1xuaW1wb3J0IHttbURpc3RhbmNlRnVuY3Rpb25UeXBlfSBmcm9tICcuL3R5cGVzJztcblxuZXhwb3J0IGZ1bmN0aW9uIGxldmVuc3RlaW4oKTogbW1EaXN0YW5jZUZ1bmN0aW9uVHlwZSB7XG4gIHJldHVybiAoc2VxMTogc3RyaW5nLCBzZXEyOiBzdHJpbmcpID0+IHtcbiAgICByZXR1cm4gZGlzdGFuY2Uoc2VxMSwgc2VxMikgLyBNYXRoLm1heChzZXExLmxlbmd0aCwgc2VxMi5sZW5ndGgpO1xuICB9O1xufVxuIl19","// Blosum 62 matrix for protein sequences\nconst BLOSUM62 = [[4, -1, -2, -2, 0, -1, -1, 0, -2, -1, -1, -1, -1, -2, -1, 1, 0, -3, -2, 0, -2, -1, 0, -4],\n    [-1, 5, 0, -2, -3, 1, 0, -2, 0, -3, -2, 2, -1, -3, -2, -1, -1, -3, -2, -3, -1, 0, -1, -4],\n    [-2, 0, 6, 1, -3, 0, 0, 0, 1, -3, -3, 0, -2, -3, -2, 1, 0, -4, -2, -3, 3, 0, -1, -4],\n    [-2, -2, 1, 6, -3, 0, 2, -1, -1, -3, -4, -1, -3, -3, -1, 0, -1, -4, -3, -3, 4, 1, -1, -4],\n    [0, -3, -3, -3, 9, -3, -4, -3, -3, -1, -1, -3, -1, -2, -3, -1, -1, -2, -2, -1, -3, -3, -2, -4],\n    [-1, 1, 0, 0, -3, 5, 2, -2, 0, -3, -2, 1, 0, -3, -1, 0, -1, -2, -1, -2, 0, 3, -1, -4],\n    [-1, 0, 0, 2, -4, 2, 5, -2, 0, -3, -3, 1, -2, -3, -1, 0, -1, -3, -2, -2, 1, 4, -1, -4],\n    [0, -2, 0, -1, -3, -2, -2, 6, -2, -4, -4, -2, -3, -3, -2, 0, -2, -2, -3, -3, -1, -2, -1, -4],\n    [-2, 0, 1, -1, -3, 0, 0, -2, 8, -3, -3, -1, -2, -1, -2, -1, -2, -2, 2, -3, 0, 0, -1, -4],\n    [-1, -3, -3, -3, -1, -3, -3, -4, -3, 4, 2, -3, 1, 0, -3, -2, -1, -3, -1, 3, -3, -3, -1, -4],\n    [-1, -2, -3, -4, -1, -2, -3, -4, -3, 2, 4, -2, 2, 0, -3, -2, -1, -2, -1, 1, -4, -3, -1, -4],\n    [-1, 2, 0, -1, -3, 1, 1, -2, -1, -3, -2, 5, -1, -3, -1, 0, -1, -3, -2, -2, 0, 1, -1, -4],\n    [-1, -1, -2, -3, -1, 0, -2, -3, -2, 1, 2, -1, 5, 0, -2, -1, -1, -1, -1, 1, -3, -1, -1, -4],\n    [-2, -3, -3, -3, -2, -3, -3, -3, -1, 0, 0, -3, 0, 6, -4, -2, -2, 1, 3, -1, -3, -3, -1, -4],\n    [-1, -2, -2, -1, -3, -1, -1, -2, -2, -3, -3, -1, -2, -4, 7, -1, -1, -4, -3, -2, -2, -1, -2, -4],\n    [1, -1, 1, 0, -1, 0, 0, 0, -1, -2, -2, 0, -1, -2, -1, 4, 1, -3, -2, -2, 0, 0, 0, -4],\n    [0, -1, 0, -1, -1, -1, -1, -2, -2, -1, -1, -1, -1, -2, -1, 1, 5, -2, -2, 0, -1, -1, 0, -4],\n    [-3, -3, -4, -4, -2, -2, -3, -2, -2, -3, -2, -3, -1, 1, -4, -3, -2, 11, 2, -3, -4, -3, -2, -4],\n    [-2, -2, -2, -3, -2, -1, -2, -3, 2, -1, -1, -2, -1, 3, -3, -2, -2, 2, 7, -1, -3, -2, -1, -4],\n    [0, -3, -3, -3, -1, -2, -2, -3, -3, 3, 1, -2, 1, -1, -2, -2, 0, -3, -1, 4, -3, -2, -1, -4],\n    [-2, -1, 3, 4, -3, 0, 1, -1, 0, -3, -4, 0, -3, -3, -2, 0, -1, -4, -3, -3, 4, 1, -1, -4],\n    [-1, 0, 0, 1, -3, 3, 4, -2, 0, -3, -3, 1, -1, -3, -1, 0, -1, -3, -2, -2, 1, 4, -1, -4],\n    [0, -1, -1, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, 0, 0, -2, -1, -1, -1, -1, -1, -4],\n    [-4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, 1]];\n// Protein indexes for BLOSUM matrix\nconst ProtIndexes = {\n    'A': 0, 'R': 1, 'N': 2, 'D': 3, 'C': 4, 'Q': 5, 'E': 6, 'G': 7, 'H': 8,\n    'I': 9, 'L': 10, 'K': 11, 'M': 12, 'F': 13, 'P': 14, 'S': 15, 'T': 16,\n    'W': 17, 'Y': 18, 'V': 19, 'B': 20, 'Z': 21, 'X': 22, '*': 23\n};\nconst defaultArgs = {\n    gapOpen: 8,\n    gapExtend: 2,\n    scoringMatrix: BLOSUM62,\n    alphabetIndexes: ProtIndexes\n};\n/** Returns a function that calculates the distance between two sequences based on gap penalty and matrix\n * @param {Partial<NeedlemanWunchArgs>}args - arguments for Needleman-Wunch algorithm like gap penalty, Scoring matrix..\n * @return {mmDistanceFunctionType} - function that calculates the distance between two sequences\n*/\nexport function needlemanWunch(args) {\n    return (seq1, seq2) => {\n        const { gapOpen, gapExtend, scoringMatrix, alphabetIndexes } = { ...defaultArgs, ...args };\n        // As we don't need traceback, no need to store the whole matrix\n        // Intead, we will store only the last two rows\n        const matrix = [\n            new Array(seq1.length + 1).fill(0),\n            new Array(seq1.length + 1).fill(0)\n        ];\n        // similarly, we need to keep track of what operation led to the current cell\n        // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n        const verticalGaps = new Array(seq1.length + 1).fill(false);\n        const horizontalGaps = new Array(seq1.length + 1).fill(false);\n        //variables to keep track which row we are in\n        // they will swap places on each iteration\n        let prevRow = 0;\n        let currRow = 1;\n        // Initialize first row\n        for (let i = 1; i < seq1.length + 1; i++)\n            matrix[0][i] = -gapOpen - (i - 1) * gapExtend;\n        // Calculate the rest of the matrix\n        for (let i = 1; i < seq2.length + 1; i++) {\n            matrix[currRow][0] = -gapOpen - (i - 1) * gapExtend;\n            for (let j = 1; j < seq1.length + 1; j++) {\n                const diagonal = matrix[prevRow][j - 1] + scoringMatrix[alphabetIndexes[seq1[j - 1]]][alphabetIndexes[seq2[i - 1]]];\n                const top = matrix[prevRow][j] - (verticalGaps[j] ? gapExtend : gapOpen);\n                const left = matrix[currRow][j - 1] - (horizontalGaps[j - 1] ? gapExtend : gapOpen);\n                matrix[currRow][j] = Math.max(diagonal, left, top);\n                // update gap arrays\n                if (matrix[currRow][j] === diagonal) {\n                    verticalGaps[j] = false;\n                    horizontalGaps[j] = false;\n                }\n                else if (matrix[currRow][j] === left) {\n                    verticalGaps[j] = false;\n                    horizontalGaps[j] = true;\n                }\n                else {\n                    verticalGaps[j] = true;\n                    horizontalGaps[j] = false;\n                }\n            }\n            // Swap rows\n            prevRow = currRow;\n            currRow = (currRow + 1) % 2;\n        }\n        // as the matrix is the similarity matrix, but we are interested in distance,\n        // we need compare it to perfect match score to get reasonable distance\n        const perfectMatchSeq1 = seq1.split('').map((c) => scoringMatrix[alphabetIndexes[c]][alphabetIndexes[c]])\n            .reduce((a, b) => a + b, 0);\n        const perfectMatchSeq2 = seq2.split('').map((c) => scoringMatrix[alphabetIndexes[c]][alphabetIndexes[c]])\n            .reduce((a, b) => a + b, 0);\n        const maxScore = Math.max(perfectMatchSeq1, perfectMatchSeq2);\n        return (maxScore - matrix[prevRow][seq1.length]) / maxScore;\n    };\n}\n//# 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{mmDistanceFunctionArgs, mmDistanceFunctionType} from './types';\n\n// Blosum 62 matrix for protein sequences\nconst BLOSUM62:Array<Array<number>> =\n[[4, -1, -2, -2, 0, -1, -1, 0, -2, -1, -1, -1, -1, -2, -1, 1, 0, -3, -2, 0, -2, -1, 0, -4],\n  [-1, 5, 0, -2, -3, 1, 0, -2, 0, -3, -2, 2, -1, -3, -2, -1, -1, -3, -2, -3, -1, 0, -1, -4],\n  [-2, 0, 6, 1, -3, 0, 0, 0, 1, -3, -3, 0, -2, -3, -2, 1, 0, -4, -2, -3, 3, 0, -1, -4],\n  [-2, -2, 1, 6, -3, 0, 2, -1, -1, -3, -4, -1, -3, -3, -1, 0, -1, -4, -3, -3, 4, 1, -1, -4],\n  [0, -3, -3, -3, 9, -3, -4, -3, -3, -1, -1, -3, -1, -2, -3, -1, -1, -2, -2, -1, -3, -3, -2, -4],\n  [-1, 1, 0, 0, -3, 5, 2, -2, 0, -3, -2, 1, 0, -3, -1, 0, -1, -2, -1, -2, 0, 3, -1, -4],\n  [-1, 0, 0, 2, -4, 2, 5, -2, 0, -3, -3, 1, -2, -3, -1, 0, -1, -3, -2, -2, 1, 4, -1, -4],\n  [0, -2, 0, -1, -3, -2, -2, 6, -2, -4, -4, -2, -3, -3, -2, 0, -2, -2, -3, -3, -1, -2, -1, -4],\n  [-2, 0, 1, -1, -3, 0, 0, -2, 8, -3, -3, -1, -2, -1, -2, -1, -2, -2, 2, -3, 0, 0, -1, -4],\n  [-1, -3, -3, -3, -1, -3, -3, -4, -3, 4, 2, -3, 1, 0, -3, -2, -1, -3, -1, 3, -3, -3, -1, -4],\n  [-1, -2, -3, -4, -1, -2, -3, -4, -3, 2, 4, -2, 2, 0, -3, -2, -1, -2, -1, 1, -4, -3, -1, -4],\n  [-1, 2, 0, -1, -3, 1, 1, -2, -1, -3, -2, 5, -1, -3, -1, 0, -1, -3, -2, -2, 0, 1, -1, -4],\n  [-1, -1, -2, -3, -1, 0, -2, -3, -2, 1, 2, -1, 5, 0, -2, -1, -1, -1, -1, 1, -3, -1, -1, -4],\n  [-2, -3, -3, -3, -2, -3, -3, -3, -1, 0, 0, -3, 0, 6, -4, -2, -2, 1, 3, -1, -3, -3, -1, -4],\n  [-1, -2, -2, -1, -3, -1, -1, -2, -2, -3, -3, -1, -2, -4, 7, -1, -1, -4, -3, -2, -2, -1, -2, -4],\n  [1, -1, 1, 0, -1, 0, 0, 0, -1, -2, -2, 0, -1, -2, -1, 4, 1, -3, -2, -2, 0, 0, 0, -4],\n  [0, -1, 0, -1, -1, -1, -1, -2, -2, -1, -1, -1, -1, -2, -1, 1, 5, -2, -2, 0, -1, -1, 0, -4],\n  [-3, -3, -4, -4, -2, -2, -3, -2, -2, -3, -2, -3, -1, 1, -4, -3, -2, 11, 2, -3, -4, -3, -2, -4],\n  [-2, -2, -2, -3, -2, -1, -2, -3, 2, -1, -1, -2, -1, 3, -3, -2, -2, 2, 7, -1, -3, -2, -1, -4],\n  [0, -3, -3, -3, -1, -2, -2, -3, -3, 3, 1, -2, 1, -1, -2, -2, 0, -3, -1, 4, -3, -2, -1, -4],\n  [-2, -1, 3, 4, -3, 0, 1, -1, 0, -3, -4, 0, -3, -3, -2, 0, -1, -4, -3, -3, 4, 1, -1, -4],\n  [-1, 0, 0, 1, -3, 3, 4, -2, 0, -3, -3, 1, -1, -3, -1, 0, -1, -3, -2, -2, 1, 4, -1, -4],\n  [0, -1, -1, -1, -2, -1, -1, -1, -1, -1, -1, -1, -1, -1, -2, 0, 0, -2, -1, -1, -1, -1, -1, -4],\n  [-4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, -4, 1]];\n\n// Protein indexes for BLOSUM matrix\nconst ProtIndexes: {[id:string]:number} = {\n  'A': 0, 'R': 1, 'N': 2, 'D': 3, 'C': 4, 'Q': 5, 'E': 6, 'G': 7, 'H': 8,\n  'I': 9, 'L': 10, 'K': 11, 'M': 12, 'F': 13, 'P': 14, 'S': 15, 'T': 16,\n  'W': 17, 'Y': 18, 'V': 19, 'B': 20, 'Z': 21, 'X': 22, '*': 23\n};\n\ntype NeedlemanWunchArgs = mmDistanceFunctionArgs & {\n  gapOpen: number;\n  gapExtend: number;\n}\n\nconst defaultArgs: NeedlemanWunchArgs = {\n  gapOpen: 8,\n  gapExtend: 2,\n  scoringMatrix: BLOSUM62,\n  alphabetIndexes: ProtIndexes\n};\n\n/** Returns a function that calculates the distance between two sequences based on gap penalty and matrix\n * @param {Partial<NeedlemanWunchArgs>}args - arguments for Needleman-Wunch algorithm like gap penalty, Scoring matrix..\n * @return {mmDistanceFunctionType} - function that calculates the distance between two sequences\n*/\nexport function needlemanWunch(args: Partial<NeedlemanWunchArgs>): mmDistanceFunctionType {\n  return (seq1: string, seq2: string) : number => {\n    const {gapOpen, gapExtend, scoringMatrix, alphabetIndexes} = {...defaultArgs, ...args};\n    // As we don't need traceback, no need to store the whole matrix\n    // Intead, we will store only the last two rows\n    const matrix: number[][] = [\n      new Array<number>(seq1.length + 1).fill(0),\n      new Array<number>(seq1.length + 1).fill(0)\n    ];\n    // similarly, we need to keep track of what operation led to the current cell\n    // i.e. whether we came from the left, top or diagonal to assign gap open/gap extend penalty\n    const verticalGaps: boolean[] = new Array<boolean>(seq1.length + 1).fill(false);\n    const horizontalGaps: boolean[] = new Array<boolean>(seq1.length + 1).fill(false);\n\n    //variables to keep track which row we are in\n    // they will swap places on each iteration\n    let prevRow = 0;\n    let currRow = 1;\n    // Initialize first row\n    for (let i = 1; i < seq1.length + 1; i++)\n      matrix[0][i] = -gapOpen - (i - 1) * gapExtend;\n\n    // Calculate the rest of the matrix\n    for (let i = 1; i < seq2.length + 1; i++) {\n      matrix[currRow][0] = -gapOpen - (i - 1) * gapExtend;\n      for (let j = 1; j < seq1.length + 1; j++) {\n        const diagonal =\n          matrix[prevRow][j - 1] + scoringMatrix[alphabetIndexes[seq1[j - 1]]][alphabetIndexes[seq2[i - 1]]];\n        const top = matrix[prevRow][j] - (verticalGaps[j] ? gapExtend : gapOpen );\n        const left = matrix[currRow][j - 1] - (horizontalGaps[j - 1] ? gapExtend : gapOpen);\n        matrix[currRow][j] = Math.max(\n          diagonal, left, top\n        );\n        // update gap arrays\n        if (matrix[currRow][j] === diagonal) {\n          verticalGaps[j] = false;\n          horizontalGaps[j] = false;\n        } else if (matrix[currRow][j] === left) {\n          verticalGaps[j] = false;\n          horizontalGaps[j] = true;\n        } else {\n          verticalGaps[j] = true;\n          horizontalGaps[j] = false;\n        }\n      }\n      // Swap rows\n      prevRow = currRow;\n      currRow = (currRow + 1) % 2;\n    }\n    // as the matrix is the similarity matrix, but we are interested in distance,\n    // we need compare it to perfect match score to get reasonable distance\n    const perfectMatchSeq1 = seq1.split('').map((c) => scoringMatrix[alphabetIndexes[c]][alphabetIndexes[c]])\n      .reduce((a, b) => a + b, 0);\n    const perfectMatchSeq2 = seq2.split('').map((c) => scoringMatrix[alphabetIndexes[c]][alphabetIndexes[c]])\n      .reduce((a, b) => a + b, 0);\n    const maxScore = Math.max(perfectMatchSeq1, perfectMatchSeq2);\n    return (maxScore - matrix[prevRow][seq1.length]) / maxScore;\n  };\n}\n"]}","const peq = new Uint32Array(0x10000);\nconst myers_32 = (a, b) => {\n    const n = a.length;\n    const m = b.length;\n    const lst = 1 << (n - 1);\n    let pv = -1;\n    let mv = 0;\n    let sc = n;\n    let i = n;\n    while (i--) {\n        peq[a.charCodeAt(i)] |= 1 << i;\n    }\n    for (i = 0; i < m; i++) {\n        let eq = peq[b.charCodeAt(i)];\n        const xv = eq | mv;\n        eq |= ((eq & pv) + pv) ^ pv;\n        mv |= ~(eq | pv);\n        pv &= eq;\n        if (mv & lst) {\n            sc++;\n        }\n        if (pv & lst) {\n            sc--;\n        }\n        mv = (mv << 1) | 1;\n        pv = (pv << 1) | ~(xv | mv);\n        mv &= xv;\n    }\n    i = n;\n    while (i--) {\n        peq[a.charCodeAt(i)] = 0;\n    }\n    return sc;\n};\nconst myers_x = (b, a) => {\n    const n = a.length;\n    const m = b.length;\n    const mhc = [];\n    const phc = [];\n    const hsize = Math.ceil(n / 32);\n    const vsize = Math.ceil(m / 32);\n    for (let i = 0; i < hsize; i++) {\n        phc[i] = -1;\n        mhc[i] = 0;\n    }\n    let j = 0;\n    for (; j < vsize - 1; j++) {\n        let mv = 0;\n        let pv = -1;\n        const start = j * 32;\n        const vlen = Math.min(32, m) + start;\n        for (let k = start; k < vlen; k++) {\n            peq[b.charCodeAt(k)] |= 1 << k;\n        }\n        for (let i = 0; i < n; i++) {\n            const eq = peq[a.charCodeAt(i)];\n            const pb = (phc[(i / 32) | 0] >>> i) & 1;\n            const mb = (mhc[(i / 32) | 0] >>> i) & 1;\n            const xv = eq | mv;\n            const xh = ((((eq | mb) & pv) + pv) ^ pv) | eq | mb;\n            let ph = mv | ~(xh | pv);\n            let mh = pv & xh;\n            if ((ph >>> 31) ^ pb) {\n                phc[(i / 32) | 0] ^= 1 << i;\n            }\n            if ((mh >>> 31) ^ mb) {\n                mhc[(i / 32) | 0] ^= 1 << i;\n            }\n            ph = (ph << 1) | pb;\n            mh = (mh << 1) | mb;\n            pv = mh | ~(xv | ph);\n            mv = ph & xv;\n        }\n        for (let k = start; k < vlen; k++) {\n            peq[b.charCodeAt(k)] = 0;\n        }\n    }\n    let mv = 0;\n    let pv = -1;\n    const start = j * 32;\n    const vlen = Math.min(32, m - start) + start;\n    for (let k = start; k < vlen; k++) {\n        peq[b.charCodeAt(k)] |= 1 << k;\n    }\n    let score = m;\n    for (let i = 0; i < n; i++) {\n        const eq = peq[a.charCodeAt(i)];\n        const pb = (phc[(i / 32) | 0] >>> i) & 1;\n        const mb = (mhc[(i / 32) | 0] >>> i) & 1;\n        const xv = eq | mv;\n        const xh = ((((eq | mb) & pv) + pv) ^ pv) | eq | mb;\n        let ph = mv | ~(xh | pv);\n        let mh = pv & xh;\n        score += (ph >>> (m - 1)) & 1;\n        score -= (mh >>> (m - 1)) & 1;\n        if ((ph >>> 31) ^ pb) {\n            phc[(i / 32) | 0] ^= 1 << i;\n        }\n        if ((mh >>> 31) ^ mb) {\n            mhc[(i / 32) | 0] ^= 1 << i;\n        }\n        ph = (ph << 1) | pb;\n        mh = (mh << 1) | mb;\n        pv = mh | ~(xv | ph);\n        mv = ph & xv;\n    }\n    for (let k = start; k < vlen; k++) {\n        peq[b.charCodeAt(k)] = 0;\n    }\n    return score;\n};\nconst distance = (a, b) => {\n    if (a.length < b.length) {\n        const tmp = b;\n        b = a;\n        a = tmp;\n    }\n    if (b.length === 0) {\n        return a.length;\n    }\n    if (a.length <= 32) {\n        return myers_32(a, b);\n    }\n    return myers_x(a, b);\n};\nconst closest = (str, arr) => {\n    let min_distance = Infinity;\n    let min_index = 0;\n    for (let i = 0; i < arr.length; i++) {\n        const dist = distance(str, arr[i]);\n        if (dist < min_distance) {\n            min_distance = dist;\n            min_index = i;\n        }\n    }\n    return arr[min_index];\n};\nexport { closest, distance };\n"],"names":["isNil","x","hamming","args","distanceF","scoringMatrix","alphabetIndexes","a","b","length","Object","keys","Error","indexes","matrix","minCharCode","Math","min","map","k","charCodeAt","scorringArray","Float32Array","entries","forEach","key","index","matrixRow","key2","index2","getDistanceF","threshold","seq1","seq2","diff","s1l","s2l","thresholdLimit","max","abs","result","i","levenstein","defaultArgs","gapOpen","gapExtend","needlemanWunch","Array","fill","verticalGaps","horizontalGaps","prevRow","currRow","j","diagonal","top","left","perfectMatchSeq1","split","c","reduce","perfectMatchSeq2","maxScore","peq","Uint32Array","distance","tmp","n","m","lst","pv","mv","sc","eq","xv","myers_32","mhc","phc","hsize","ceil","vsize","start","vlen","pb","mb","xh","ph","mh","score","myers_x"],"sourceRoot":""}

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