@datagrok/bio 2.10.6 → 2.10.8

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Files changed (9) hide show
  1. package/CHANGELOG.md +1 -0
  2. package/dist/package-test.js +1 -1
  3. package/dist/package-test.js.map +1 -1
  4. package/dist/package.js +1 -1
  5. package/dist/package.js.map +1 -1
  6. package/package.json +1 -1
  7. package/src/tests/detectors-benchmark-tests.ts +3 -3
  8. package/src/utils/enumerator-tools.ts +193 -60
  9. package/src/utils/monomer-lib.ts +0 -6
package/dist/package.js CHANGED
@@ -1,2 +1,2 @@
1
- var bio;(()=>{var t={2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>i});var n=s(9976);class i extends n.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in i.aaSynonyms?i.aaSynonyms[t]:t;return super.get(e)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",n="";for(const i of t)"("==i?e++:")"==i?e--:e?s+=i:n+=i;return isNaN(parseInt(s))?[n,s]:[n,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[n,i]=this.getInnerOuter(t);if(n=n.length>6?`${n.slice(0,3)}...`:n,i=i.length>6?`${i.slice(0,3)}...`:i,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,i,1]:[this.undefinedColor,n,i,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,i,2]:[this.undefinedColor,n,i,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,i,3]:[this.undefinedColor,n,i,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,i,4]:[this.undefinedColor,n,i,4]}return[this.undefinedColor,n,i,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>c,Qx:()=>u,Xk:()=>h,Z:()=>l,eD:()=>a});var n=s(976),i=s(4469),r=s(1047),o=(s(499),s(8457));function a(t){return t.every((t=>"object"==typeof t&&Object.values(r.pn).every((e=>e in t&&"string"==typeof t[e]))))}function l(t){function e(t){const e=new RegExp("\\[r\\]","g");let s=0;return t.replace(e,(t=>(++s,`[${s}*]`)))}const s=[];return t.forEach((t=>{const i={...r.zh};Object.entries(r.pn).forEach((([e,s])=>{const n=t[s];i[e]=n}));let o="smiles";const a=t[r.pn[o]],l=e(a).replace("[1*]","[H:1]").replace("[2*]","[OH:2]");i[o]=l,o="rgroups",i[o]=r.Ei,o="molfile";const h=e(a),c=n.chem.convert(h,n.chem.Notation.Smiles,n.chem.Notation.MolBlock);i[o]=c.replace("M ISO","M RGP"),s.push(i)})),console.log("resultLib:",s),s}function h(t){const e=[];for(let s=0;s<t.rowCount;s++){const n={};Object.keys(r.K4).forEach((e=>{if("symbol"===e){const i=t.get(r.K4[e],s);n[e]="."===i?t.get(r.At,s):i}else if("rgroups"===e){const i=t.get(r.K4[e],s).split("\n"),o=[];i.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),n=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${n}][H]`:`O[*:${n}]`,e.alternateId="H"===s?`R${n}-H`:`R${n}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${n}`,o.push(e)})),n[e]=o}else r.K4[e]&&(n[e]=t.get(r.K4[e],s))})),e.push(n)}return e}async function c(){const t=n.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e){t instanceof n.Column&&(t=(0,o.O)(t).columns.toList());const s=(await c()).getBioLib(),r=new Array(t.length),a=t[0].length,l=new Float32Array(a);for(let o=0;o<t.length;++o){const h=e[o],c=s.getMonomer("PEPTIDE",h)?.smiles??"",u=t[o],d=u.getRawData(),m=u.categories,p=m.indexOf("");if(r[o]={categories:m,data:d,emptyIndex:p},void 0===h)continue;const g=n.Column.fromStrings("smiles",m.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(n.DataFrame.fromColumns([g]),(await i.chem.getSimilarities(g,c)).getRawData());for(let t=0;t<a;++t){const e=d[t];l[t]+=""!==h&&e!==p?f[e]:""===h&&e===p?1:0}}for(let s=0;s<l.length;++s){let i=l[s]/e.length;for(let o=0;o<t.length;++o){const t=r[o];if(o>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&o<e.length){i=n.FLOAT_NULL;break}}l[s]=i}return n.Column.fromFloat32Array("Similarity",l)}},8601:(t,e,s)=>{"use strict";s.d(e,{i0:()=>d});var n=s(4469),i=s(976),r=s(6414),o=s.n(r),a=s(1821),l=s(499);const h={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var c=s(1047);function u(t){return Math.round(h.PRECISION_FACTOR*t)/h.PRECISION_FACTOR}async function d(t,e,r){if(0===i.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==i.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${i.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let u=e;const d=l.Cn.getOrCreate(e);d.isHelm()&&(u=d.convert(a.r2.SEPARATOR,"."),u.name=e.name);const p=l.Cn.getOrCreate(u).alphabet;let g;if("PT"===p||"UN"===p)g="PEPTIDE";else{if("RNA"!==p&&"DNA"!==p)return{col:null,warnings:[`Unexpected column's '${u.name}' alphabet '${p}'.`]};g="RNA"}const f=function(t){const e=t.length,s=new Array(e),n=l.Cn.getOrCreate(t).getSplitter();for(let i=0;i<e;++i){const e=t.get(i);s[i]=e?o()(n(e)).filter((t=>""!==t)).toArray():[]}return s}(u),y=await async function(t,e,s,i){const r=function(t,e,s){const n=new Map;for(const i of t.getMonomerSymbolsByType(e)){const r=t.getMonomer(e,i);if("RNA"===e&&("Branch"===r.monomerType||"DNA"===s&&r.symbol===h.DEOXYRIBOSE||"RNA"===s&&r.symbol===h.RIBOSE||r.symbol===h.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==r.monomerType){const t={};c.rx.forEach((e=>{t[e]=r[e]})),n.set(r.symbol,t)}}return n}(e,s,i),o=new Map,a=await n.functions.call("Chem:getRdKitModule"),l={value:null};if("RNA"===s){const t="RNA"===i?[h.RIBOSE,h.PHOSPHATE]:[h.DEOXYRIBOSE,h.PHOSPHATE];for(const e of t)m(o,e,r,a,s,l)}for(let e=0;e<t.length;++e){const n=t[e];for(const t of n)if(""!==t)try{m(o,t,r,a,s,l)}catch(e){const s=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n${s}\n${n}`),new Error(`Can't get monomer '${t}' from library: ${s}`)}}return o}(f,r,g,p),b=u.length,{molfileList:w,molfileWarningList:C}=await async function(t,e,n,i,r){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:n,polymerType:i,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(f,y,p,g,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const v=`molfile(${u.name})`,S=t.columns.getUnusedName(v),M=i.Column.fromStrings(S,w);return M.semType=i.SEMTYPE.MOLECULE,M.setTag(i.TAGS.UNITS,i.UNITS.Molecule.MOLBLOCK),{col:M,warnings:C}}function m(t,e,s,n,i,r){if(!t.has(e)){const o=function(t,e,s,n,i){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let s=t.indexOf(h.V2K_A_LINE,0),n=s;for(;-1!==s;){n=t.indexOf("\n",s);const i=parseInt(t.substring(s,n).replace(/^A\s+/,""));s=t.indexOf("R",n),n=t.indexOf("\n",s);const r=parseInt(t.substring(s,n).replace(/^R/,""));e.set(i,r),s=t.indexOf(h.V2K_A_LINE,n)}for(s=t.indexOf(h.V2K_RGP_LINE,0),n=t.indexOf("\n",s);-1!==s;){s+=h.V2K_RGP_SHIFT,n=t.indexOf("\n",s);const i=t.substring(s,n).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<i.length;t+=2){if(e.has(i[t])&&e.get(i[t])!==i[t+1])throw new Error(`r-group index ${i[t]} has already been added with a different value`);e.set(i[t],i[t+1])}s=t.indexOf(h.V2K_RGP_LINE,n)}return e}(r.molfile),l=function(t,e){const s=e.get_mol(t),n=s.get_v3Kmolblock();return s.delete(),n}(function(t){let e=t.indexOf(h.V2K_A_LINE,0);-1===e&&(e=t.indexOf(h.V2K_RGP_LINE));const s=t.indexOf(h.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),c=function(t){let e=(t=t.replaceAll("\r","")).indexOf(h.V3K_BEGIN_COUNTS_LINE)+h.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const n=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(t.substring(e,s))}}(l),d=function(t,e){const s=new Array(e),n=new Float32Array(e),i=new Float32Array(e),r=new Array(e);let o=t.indexOf(h.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;l++){o=t.indexOf(h.V3K_BEGIN_DATA_LINE,o)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),s[l]=t.substring(o,a);const e=new Array(2);for(let s=0;s<2;++s)o=a+1,a=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,a));n[l]=e[0],i[l]=e[1],o=a,a=t.indexOf("\n",o)+1,r[l]=t.slice(o,a),o=a}return{atomTypes:s,x:n,y:i,kwargs:r}}(l,c.atomCount),m=function(t,e){const s=new Uint32Array(e),n=new Array(e),i=new Map,r=new Map;let o=t.indexOf(h.V3K_BEGIN_BOND_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;++l){const e=new Array(3);o=t.indexOf(h.V3K_BEGIN_DATA_LINE,a)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o);for(let s=0;s<3;++s)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[s]=parseInt(t.slice(o,a));s[l]=e[0],n[l]=e.slice(1);const c=t.indexOf("\n",o);let u=t.slice(a,c),d=u.indexOf(h.V3K_BOND_CONFIG);if(-1!==d){d=u.indexOf("=",d)+1;let t=u.indexOf(" ",d);-1===t&&(t=u.length);const e=parseInt(u.slice(d,t));i.set(l,e);const s=h.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||r.set(l,u)}return{bondTypes:s,atomPairs:n,bondConfiguration:i,kwargs:r}}(l,c.bondCount),y={atoms:d,bonds:m,meta:p(d,m,o,a)};return"PEPTIDE"===n?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;M(t,-n[e],-i[e]);const r=C(n[s],i[s]);v(t.atoms,-r),n[t.meta.rNodes[1]-1]<0&&function(t){S(t,!1)}(t);const o=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const n=s[t],i=s[(t+1)%2];e.has(n)?e.get(n)?.push(i):e.set(n,new Array(1).fill(i))}return e}(t);let s=0,n=0;for(;0===s;){const i=e.get(t.meta.terminalNodes[1])[n];t.atoms.atomTypes[i-1]===h.OXYGEN&&i!==t.meta.rNodes[1]&&(s=i),n++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){S(t,!0)}(t),v(t.atoms,-function(t,e){return C(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const n=e-1,i=s-1,r=t.atoms.x,o=t.atoms.y,a=r[n],l=o[n];r[n]=r[i],o[n]=o[i],r[i]=a,o[i]=l}(t,e,t.meta.rNodes[1])}(t,o)}(y):t===h.RIBOSE||t===h.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,n=t.atoms.y;let i=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;M(t,-s[i],-n[i]);const o=C(s[r],n[r]);v(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,n=t.meta.rNodes[2]-1,i=t.meta.terminalNodes[2]-1,r=e[n]-e[i],o=s[n]-s[i];return Math.atan(o/r)+Math.PI/2}(t),i=t.meta.terminalNodes[0]-1,M(t,-s[i],-n[i])}(y,i):t===h.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;M(t,-n[e],-i[e]);const r=C(n[s],i[s]);v(t.atoms,Math.PI/2-r)}(y):function(t,e){const s=t.atoms.x,n=t.atoms.y,i=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;M(t,-s[i],-n[i]);const o=C(s[r],n[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");v(t.atoms,Math.PI-o+a);const l=function(t,e){return u(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:s[t.meta.rNodes[0]-1],y:n[t.meta.rNodes[0]-1]},{x:s[t.meta.terminalNodes[0]-1],y:n[t.meta.terminalNodes[0]-1]});if(1!=l)for(let t=0;t<s.length;++t)s[t]=u(s[t]/l),n[t]=u(n[t]/l)}(y,i),function(t,e,s){"PEPTIDE"===t?(f(e,t),b(e,e.meta.rNodes[1])):s===h.RIBOSE||s===h.DEOXYRIBOSE?(b(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],g(e.bonds,e.meta),f(e,t),b(e,e.meta.rNodes[1]),b(e,e.meta.rNodes[0]),b(e,e.meta.rNodes[2])):s===h.PHOSPHATE&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],M(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),f(e,t),b(e,e.meta.rNodes[1]))}(n,y,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===h.HYDROGEN&&(b(t,e+1),--e),++e}(y),y}return null}(e,s,n,i,r);if(!o)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);t.set(e,o)}}function p(t,e,s,n){const 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";return n?i.substring(0,e-1)+"…":i}function T(t,e,s="-"){const n=e.map((e=>{const n=function(t,e,s="-"){const n=new Set([...new Set(Object.keys(t)),...e]);n.delete(s);const i=[],r=[];for(const s of n)i.push(s in t?t[s]:0),r.push(e.has(s)?1:0);const o=new h.OW(i),a=new h.OW(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,s);return new o.d(e,t,n)}));let i;const r=Math.max(...n.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return i=r>0?n.find((t=>t.similarity===r)).name:"UN",i}function A(t,e=5){let s;if(t.semType==n.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const n=function(t,e,s){return t.categories,function(t,e){const s={};let n=!0,i=null;for(const r of t)if(null==i?i=r.length:r.length!==i&&(n=!1),r.length>=e)for(const t of r)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:n}}(r()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,p);s=T(n.freq,a.XS)}return E(s)}function E(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return d.J.Chromatogram;default:return m.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(n.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var n=s(976),i=s(6414),r=s.n(i),o=s(585);function a(t){const e=(0,o.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return i.push(e),e},i=[],a=t.length,l=n.DataFrame.create(a);for(let n=0;n<a;++n){const o=t.get(n);if(null==o)continue;const a=e(o);for(const[t,e]of r().enumerate(a))((i[e]??null)||s(e)).set(n,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>d});var n=s(976),i=s(6414),r=s.n(i),o=s(8447),a=s(585),l=s(489),h=s(7228);const c=new class{constructor(){this.uhTemp=`units-handler.${n.SEMTYPE.MACROMOLECULE}`}},u={[o.r2.FASTA]:"-",[o.r2.SEPARATOR]:"",[o.r2.HELM]:"*"};class d{static setUnitsToFastaColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.FASTA)throw new Error(`The column of notation '${o.r2.FASTA}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(n.TAGS.UNITS,o.r2.FASTA),d.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.SEPARATOR)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(n.TAGS.UNITS,o.r2.SEPARATOR),t.column.setTag("separator",e),d.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.r2.HELM}' must be '${n.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(n.TAGS.UNITS,o.r2.HELM),d.setTags(t)}static setTags(t){const e=t.column.getTag(n.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[o.r2.FASTA,o.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");let e=t.column.getTag("aligned");null===e&&(e=s.sameLength?"SEQ.MSA":"SEQ",t.column.setTag("aligned",e));let n=t.column.getTag("alphabet");if(null===n&&(n=(0,a.w4)(s.freq,o.XS),t.column.setTag("alphabet",n)),"UN"===n){const e=Object.keys(s.freq).length,n=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",n?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===o.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==o.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),n=this._column.categories;for(let i=0;i<e;i++){const e=n[s[i]];this._splitted[i]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const n of this.splitted){null==s?s=n.length:n.length!==s&&(e=!1);for(const e of n)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=Math.max(...this.splitted.map((t=>t.length)))),this._maxLength}get posList(){if(null===this._posList){const t=this.column.getTag(".positionNames");this._posList=t?t.split(o.CI).map((t=>t.trim())):r().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.r2.FASTA}isSeparator(){return this.notation===o.r2.SEPARATOR}isHelm(){return this.notation===o.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===o.r2.FASTA&&t===u[o.r2.FASTA]||this.units===o.r2.HELM&&t===u[o.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return o.r2.FASTA;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return o.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,i=s.length,r=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(r),l=n.Column.fromList("string",a,new Array(i).fill(""));if(l.semType=n.SEMTYPE.MACROMOLECULE,l.setTag(n.TAGS.UNITS,t),t===o.r2.SEPARATOR){if(!e)throw new Error(`Notation '${o.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(n.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const d=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==d&&l.setTag(".alphabetIsMultichar",d),t==o.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=d.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[o.r2.FASTA,o.r2.SEPARATOR,o.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!d.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const i=n.Column.fromList("string",e,new Array(t).fill(""));return i.semType=n.SEMTYPE.MACROMOLECULE,i.setTag(n.TAGS.UNITS,s),i}getSplitter(t){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?a.kB:a.FJ;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return(0,a.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(o.r2.HELM))return a.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return l.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return l.U.LEVENSHTEIN;case"PT":return l.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return l.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,h.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,a.Ar)(this.separator);for(const t of this.column.categories){const n=s(t);for(const t of n)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,n){n||(n=this.toFasta(e)?u[o.r2.FASTA]:u[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const i=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let s=a[t];if(r&&(s=s.replace(i,"")),s===u[o.r2.HELM])l.push(n);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";l.push(t)}else l.push(s)}return l.join(s)}convert(t,e){const s=this.getConverter(t,e),n=this.getNewColumn(t,e);return n.init((t=>s(this.column.get(t)))),n}getRegion(t,e,s){const n=this.getNewColumn(this.notation,this.separator);n.name=s,Math.max(...this.splitted.map((t=>t.length)));const i=t??0,r=e??this.maxLength-1,a=this.getJoiner(),l=r-i+1;n.init((t=>{const e=this.splitted[t],s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:u[this.notation]}return a(s)}));const h=t=>{const e=t.split(",").map((t=>t.trim())),s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:"?"}return s.join(o.CI)},c=this.column.getTag(".positionNames");c&&n.setTag(".positionNames",h(c));const d=this.column.getTag(".positionLabels");return d&&n.setTag(".positionLabels",h(d)),n}getJoiner(){const t=this;if(this.notation===o.r2.FASTA)return function(e){return p(t,e)};if(this.notation===o.r2.SEPARATOR)return function(e){return g(t,e,t.separator)};if(this.notation===o.r2.HELM){const e="DNA"===t.alphabet||"RNA"===t.alphabet;return function(s){return f(t,s,e)}}throw new Error}getConverter(t,e=undefined){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?y(t,e):t.getSplitter()(e);return p(t,s)}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA")||e.startsWith("RNA"),n=t.getSplitter()(e);return f(t,n,s)}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const n=t.isHelm()?y(t,e):t.getSplitter()(e);return g(t,n,s)}(s,t,e)};throw new Error}constructor(t){if(this._splitter=null,this._splitted=null,this._stats=null,this._maxLength=null,this._posList=null,t.type!=n.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${n.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(n.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?u[o.r2.FASTA]:this.isHelm()?u[o.r2.HELM]:u[o.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())d.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");d.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(n.TAGS.UNITS)}'.`);d.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return c.uhTemp in t.temp||(t.temp[c.uhTemp]=new d(t)),t.temp[c.uhTemp]}}const m=/[RD]\((\w)\)P?/g;function p(t,e){const s=new Array(e.length);for(const[n,i]of r().enumerate(e)){let r=n;t.isHelm()&&(r=n.replace(m,"$1")),t.isGap(r)?r=u[o.r2.FASTA]:r.length>1&&(r="["+e[i]+"]"),s[i]=r}return s.join("")}function g(t,e,s){const n=new Array(e.length);for(const[s,i]of r().enumerate(e)){let e=s;t.isGap(e)&&(e=u[o.r2.SEPARATOR]),n[i]=e}return n.map((t=>t??"")).join(s)}function f(t,e,s){const[n,i,a,l]=t.getHelmWrappers();return`${n}${r()(e).map((e=>{let n=e;return n=t.isGap(n)?u[o.r2.HELM]:s?n.replace(m,"$1"):1==e.length?`${i}${e}${a}`:`${i}[${e}]${a}`,n})).toArray().join(".")}${l}`}function y(t,e){const s=t.getSplitter()(e),n=new Array(s.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of r().enumerate(s)){let s=t;(i||o)&&(s=s.replace(m,"$1"),s="P"===s?null:s),n[e]=s}return n.filter((t=>null!==t))}},9298:(t,e,s)=>{"use strict";var n,i,r,o,a,l;s.d(e,{Ct:()=>l,DX:()=>n,ES:()=>i,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.tooltipWebLogo=".tooltipWebLogo"}(n||(n={})),function(t){t.Entropy="Entropy",t.full="100%"}(i||(i={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=i.Entropy,this.positionWidth=16,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>n});class n{constructor(t=!0,e=!0){const n=navigator.hardwareConcurrency;this._workerCount=t?Math.max(n-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(18),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0){return new Promise((async(n,i)=>{try{const i=t.length,r=new Array(this._workerCount),o=i*(i-1)/2;this._workerCount=Math.min(this._workerCount,o);const a=o/this._workerCount,l=new 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s}minRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){b(this,t),A(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n),s[1]=n);return s}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){w(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t),s[0]=n);return s}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){w(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t),s[0]=n);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let n=0;n<e.length;n++)s+=e[n]*t[n];return s}mmul(t){t=I.checkMatrix(t);let e=this.rows,s=this.columns,n=t.columns,i=new I(e,n),r=new Float64Array(s);for(let o=0;o<n;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let n=0;n<s;n++)e+=this.get(t,n)*r[n];i.set(t,o,e)}}return i}strassen2x2(t){t=I.checkMatrix(t);let e=new I(2,2);const s=this.get(0,0),n=t.get(0,0),i=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(n+h),u=(o+l)*n,d=s*(r-h),m=l*(a-n),p=(s+i)*h,g=c+m-p+(i-l)*(a+h),f=d+p,y=u+m,b=c-u+d+(o-s)*(n+r);return e.set(0,0,g),e.set(0,1,f),e.set(1,0,y),e.set(1,1,b),e}strassen3x3(t){t=I.checkMatrix(t);let e=new I(3,3);const s=this.get(0,0),n=this.get(0,1),i=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),d=t.get(0,1),m=t.get(0,2),p=t.get(1,0),g=t.get(1,1),f=t.get(1,2),y=t.get(2,0),b=t.get(2,1),w=t.get(2,2),C=(s-r)*(-d+g),v=(-s+r+o)*(u-d+g),S=(r+o)*(-u+d),M=s*u,T=(-s+l+h)*(u-m+f),A=(-s+l)*(m-f),E=(l+h)*(-u+m),x=(-i+h+c)*(g+y-b),N=(i-c)*(g-b),L=i*y,_=(h+c)*(-y+b),R=(-i+o+a)*(f+y-w),O=(i-a)*(f-w),k=(o+a)*(-y+w),P=M+L+n*p,G=(s+n+i-r-o-h-c)*g+v+S+M+x+L+_,F=M+T+E+(s+n+i-o-a-l-h)*f+L+R+k,W=C+o*(-u+d+p-g-f-y+w)+v+M+L+R+O,V=C+v+S+M+a*b,H=L+R+O+k+r*m,D=M+T+A+h*(-u+m+p-g-f-y+b)+x+N+L,B=x+N+L+_+l*d,U=M+T+A+E+c*w;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,D),e.set(2,1,B),e.set(2,2,U),e}mmulStrassen(t){t=I.checkMatrix(t);let e=this.clone(),s=e.rows,n=e.columns,i=t.rows,r=t.columns;function o(t,e,s){let n=t.rows,i=t.columns;if(n===e&&i===s)return t;{let n=E.zeros(e,s);return n=n.setSubMatrix(t,0,0),n}}n!==i&&console.warn(`Multiplying ${s} x ${n} and ${i} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,i),l=Math.max(n,r);return e=o(e,a,l),function t(e,s,n,i){if(n<=512||i<=512)return e.mmul(s);n%2==1&&i%2==1?(e=o(e,n+1,i+1),s=o(s,n+1,i+1)):n%2==1?(e=o(e,n+1,i),s=o(s,n+1,i)):i%2==1&&(e=o(e,n,i+1),s=o(s,n,i+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),d=e.subMatrix(r,e.rows-1,0,a-1),m=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),g=s.subMatrix(r,s.rows-1,a,s.columns-1),f=t(E.add(l,p),E.add(h,g),r,a),y=t(E.add(d,p),h,r,a),b=t(l,E.sub(u,g),r,a),w=t(p,E.sub(m,h),r,a),C=t(E.add(l,c),g,r,a),v=t(E.sub(d,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(m,g),r,a),M=E.add(f,w);M.sub(C),M.add(S);let T=E.add(b,C),A=E.add(y,w),x=E.sub(f,y);x.add(b),x.add(v);let I=E.zeros(2*M.rows,2*M.columns);return I=I.setSubMatrix(M,0,0),I=I.setSubMatrix(T,M.rows,0),I=I.setSubMatrix(A,0,M.columns),I=I.setSubMatrix(x,M.rows,M.columns),I.subMatrix(0,n-1,0,i-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new I(this.rows,this.columns);for(let t=0;t<this.rows;t++){const i=this.getRow(t);i.length>0&&d(i,{min:e,max:s,output:i}),n.setRow(t,i)}return n}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new I(this.rows,this.columns);for(let t=0;t<this.columns;t++){const i=this.getColumn(t);i.length&&d(i,{min:e,max:s,output:i}),n.setColumn(t,i)}return n}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),n=this.get(e,this.columns-1-s);this.set(e,s,n),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),n=this.get(this.rows-1-s,e);this.set(s,e,n),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=I.checkMatrix(t);let e=this.rows,s=this.columns,n=t.rows,i=t.columns,r=new I(e*n,s*i);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<n;s++)for(let a=0;a<i;a++)r.set(n*o+s,i*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=I.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,n=this.kroneckerProduct(I.eye(s,s)),i=I.eye(e,e).kroneckerProduct(t);return n.add(i)}transpose(){let t=new I(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,n){S(this,t,e,s,n);let i=new I(e-t+1,n-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=n;e++)i.set(r-t,e-s,this.get(r,e));return i}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let n=new I(t.length,s-e+1);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.rows)throw new RangeError(`Row index out of range: ${t[i]}`);n.set(i,r-e,this.get(t[i],r))}return n}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let n=new I(s-e+1,t.length);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.columns)throw new RangeError(`Column index out of range: ${t[i]}`);n.set(r-e,i,this.get(r,t[i]))}return n}setSubMatrix(t,e,s){if((t=I.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)this.set(e+n,s+i,t.get(n,i));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new I(t.length,e.length);for(let n=0;n<t.length;n++){let i=t[n];for(let t=0;t<e.length;t++){let r=e[t];s.set(n,t,this.get(i,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new I(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=M(t.rows);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]+=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]+=t.get(s,n);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e+=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=M(t.rows,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]*=t.get(s,n);return e}(this);case"column":return function(t){let e=M(t.columns,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]*=t.get(s,n);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e*=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:n=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(o,e)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,n);case"column":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(e,o)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,n);case void 0:if("number"!=typeof n)throw new TypeError("mean must be a number");return function(t,e,s){const n=t.rows,i=t.columns,r=n*i;let o=0,a=0,l=0;for(let e=0;e<n;e++)for(let n=0;n<i;n++)l=t.get(e,n)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,n);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[n])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let n=0;for(let e=0;e<t.columns;e++)n+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let n=0;for(let e=0;e<t.rows;e++)n+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[n])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let n=0;n<t.columns;n++)for(let i=0;i<t.rows;i++)s+=Math.pow(t.get(i,n),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return g(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return g(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class I extends E{constructor(t,e){if(super(),I.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let n=0;n<t;n++){if(s[n].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[n].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[n]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return b(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),b(this,t,!0),e=Float64Array.from(C(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let n=0;n<t;n++)s[n]=this.data[e][n];for(let n=t+1;n<this.columns;n++)s[n-1]=this.data[e][n];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=v(this,e);for(let s=0;s<this.rows;s++){const n=new Float64Array(this.columns+1);let i=0;for(;i<t;i++)n[i]=this.data[s][i];for(n[i++]=e[s];i<this.columns+1;i++)n[i]=this.data[s][i-1];this.data[s]=n}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,I);class N extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,s,n,i,r,o,a,l,h,c=(t=N.checkMatrix(t)).clone(),u=c.rows,d=c.columns,m=new Float64Array(u),p=1;for(e=0;e<u;e++)m[e]=e;for(l=new Float64Array(u),s=0;s<d;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,n=0;n<h;n++)r+=c.get(e,n)*l[n];l[e]-=r,c.set(e,s,l[e])}for(i=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[i])&&(i=e);if(i!==s){for(n=0;n<d;n++)o=c.get(i,n),c.set(i,n,c.get(s,n)),c.set(s,n,o);a=m[i],m[i]=m[s],m[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=m,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=I.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,i,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(i=0;i<a;i++)for(s=i+1;s<a;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i));for(i=a-1;i>=0;i--){for(n=0;n<r;n++)o.set(i,n,o.get(i,n)/e.get(i,i));for(s=0;s<i;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let n=0;n<s;n++)e*=t.get(n,n);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new I(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new I(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,n,i,r=(t=N.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(n=0;n<a;n++){let t=0;for(e=n;e<o;e++)t=_(t,r.get(e,n));if(0!==t){for(r.get(n,n)<0&&(t=-t),e=n;e<o;e++)r.set(e,n,r.get(e,n)/t);for(r.set(n,n,r.get(n,n)+1),s=n+1;s<a;s++){for(i=0,e=n;e<o;e++)i+=r.get(e,n)*r.get(e,s);for(i=-i/r.get(n,n),e=n;e<o;e++)r.set(e,s,r.get(e,s)+i*r.get(e,n))}}l[n]=-t}this.QR=r,this.Rdiag=l}solve(t){t=I.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,i,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(i=0;i<a;i++){for(o=0,n=r;n<s;n++)o+=e.get(n,r)*l.get(n,i);for(o=-o/e.get(r,r),n=r;n<s;n++)l.set(n,i,l.get(n,i)+o*e.get(n,r))}for(r=h-1;r>=0;r--){for(i=0;i<a;i++)l.set(r,i,l.get(r,i)/this.Rdiag[r]);for(n=0;n<r;n++)for(i=0;i<a;i++)l.set(n,i,l.get(n,i)-l.get(r,i)*e.get(n,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,i=new I(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?i.set(t,e,s.get(t,e)):t===e?i.set(t,e,this.Rdiag[t]):i.set(t,e,0);return i}get orthogonalMatrix(){let t,e,s,n,i=this.QR,r=i.rows,o=i.columns,a=new I(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==i.get(s,s)){for(n=0,t=s;t<r;t++)n+=i.get(t,s)*a.get(t,e);for(n=-n/i.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+n*i.get(t,s))}}return a}}class O{constructor(t,e={}){if((t=N.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,n=t.columns;const{computeLeftSingularVectors:i=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(i),h=Boolean(r),c=!1;if(s<n)if(o){a=t.transpose(),s=a.rows,n=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,n),d=Math.min(s+1,n),m=new Float64Array(d),p=new I(s,u),g=new I(n,n),f=new Float64Array(n),y=new Float64Array(s),b=new Float64Array(d);for(let t=0;t<d;t++)b[t]=t;let w=Math.min(s-1,n),C=Math.max(0,Math.min(n-2,s)),v=Math.max(w,C);for(let t=0;t<v;t++){if(t<w){m[t]=0;for(let e=t;e<s;e++)m[t]=_(m[t],a.get(e,t));if(0!==m[t]){a.get(t,t)<0&&(m[t]=-m[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/m[t]);a.set(t,t,a.get(t,t)+1)}m[t]=-m[t]}for(let e=t+1;e<n;e++){if(t<w&&0!==m[t]){let n=0;for(let i=t;i<s;i++)n+=a.get(i,t)*a.get(i,e);n=-n/a.get(t,t);for(let i=t;i<s;i++)a.set(i,e,a.get(i,e)+n*a.get(i,t))}f[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<C){f[t]=0;for(let e=t+1;e<n;e++)f[t]=_(f[t],f[e]);if(0!==f[t]){f[t+1]<0&&(f[t]=0-f[t]);for(let e=t+1;e<n;e++)f[e]/=f[t];f[t+1]+=1}if(f[t]=-f[t],t+1<s&&0!==f[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<n;s++)y[e]+=f[s]*a.get(e,s);for(let e=t+1;e<n;e++){let n=-f[e]/f[t+1];for(let i=t+1;i<s;i++)a.set(i,e,a.get(i,e)+n*y[i])}}if(h)for(let e=t+1;e<n;e++)g.set(e,t,f[e])}}let S=Math.min(n,s+1);if(w<n&&(m[w]=a.get(w,w)),s<S&&(m[S-1]=0),C+1<S&&(f[C]=a.get(C,S-1)),f[S-1]=0,l){for(let t=w;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==m[t]){for(let e=t+1;e<u;e++){let n=0;for(let i=t;i<s;i++)n+=p.get(i,t)*p.get(i,e);n=-n/p.get(t,t);for(let i=t;i<s;i++)p.set(i,e,p.get(i,e)+n*p.get(i,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=n-1;t>=0;t--){if(t<C&&0!==f[t])for(let e=t+1;e<n;e++){let s=0;for(let i=t+1;i<n;i++)s+=g.get(i,t)*g.get(i,e);s=-s/g.get(t+1,t);for(let i=t+1;i<n;i++)g.set(i,e,g.get(i,e)+s*g.get(i,t))}for(let e=0;e<n;e++)g.set(e,t,0);g.set(t,t,1)}let M=S-1,T=0,A=Number.EPSILON;for(;S>0;){let 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n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(585);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",d=l.GU;var m,p;function g(t,e,s,n,i,r,o=h,a=0,l=!1,m=1,g="",f=!1,y=p.classic,b=[],w=0,C=null,v=[],S=null,M={}){i.textAlign="start";let T=r.substring(0),A=f?"":g;y===p.MSA&&(A="");let E=!0,x=!0,I="difference";null!=C&&null!=C.cell.column&&(E=C.cell.column.temp["color-code"]??!0,x=C.cell.column.temp["compare-with-current"]??!0,I=C.cell.column.temp["highlight-difference"]??"difference");const N=v[w];x&&v.length>0&&"difference"===I&&(m=T==N?.3:m),x&&v.length>0&&"equal"===I&&(m=T!=N?.3:m),null!=S&&(T=d(T,S));const L=T+A;M[L]??(M[L]=i.measureText(L));let _=M[L];M[T]??(M[T]=i.measureText(T));let R=M[T].width;M[A]??(M[A]=i.measureText(A));const O=M[A].width,k=n/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,n){const r=E?o:u;i.fillStyle=r,i.globalAlpha=m,y===p.classic&&(i.fillText(T,t+s,e+k),i.fillStyle=c,i.fillText(A,t+n,e+k)),y===p.MSA&&i.fillText(T,t+s,e+k)}_=_.width,y===p.MSA&&(R=b[w],_=b[w]);const G=(b[w]??0)-(b[0]??0);if(l||_>s)return P(G,G+R),t+G+R+O;{const e=(s-_)/2;return P(e,e+R),t+G+e+R}}!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(m||(m={})),function(t){t.MSA="MSA",t.classic="classic"}(p||(p={}));var f,y=s(9611),b=s(8447),w=s(7331),C=s(499);!function(t){t.long="long",t.short="short"}(f||(f={}));const v={true:"1",false:"0"};var S=s(3553);const M="rgb(100,100,100)",T=b.GU;function A(t,e,s,n){return t?Math.min(t.canvas.width-s,n):e.canvas.width-s}function E(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],n=e?"":" ";for(const[e,i]of a().enumerate(t)){let r=e;i<t.length&&(r+=`${e?"":"-"}${n}`),s.push(r)}return[s,e]}class x extends r.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[i.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const i={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=n.chem.svgMol(e.smiles,void 0,void 0,i);r.push(o),s._monomerStructureMap[t]=o}}i.tooltip.show(i.divV(r),e.x+16,e.y+16)}else i.tooltip.hide()}render(t,e,s,n,i,o,l){let h=0,c=50;const u=o.grid,d=o.cell.column,f=d.temp,w=f["monomer-width"];if("short"===(null!=w?w:"short")){const t=parseInt(d.getTag(m.maxMonomerLength));c=(isNaN(t)?Ve.properties?.MaxMonomerLength:t)??4}let S=d.temp["bio-seqCol"];S||(S=new y.A(u,d,(()=>{const t=C.Cn.getOrCreate(d);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:h,monomerToShort:T,monomerLengthLimit:c,monomerLib:Ye()}}))),d.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(h=f[".mm.cellRenderer.gapLength"]??h,S.setMonomerLengthLimit(c),S.setSeparatorWidth(S.isMsa()?8:h),d.setTag(".mm.cellRenderer.settingsChanged",v.false));const[E,x]=S.getCellMonomerLengths(o.tableRowIndex);E.length,S.updated&&(f["bio-seqCol"]=S),t.save();try{const l=-1!==o.gridRow?o.grid:null,h=o.cell.value,u=d.getTag("alphabet"),m=50;n=A(l,t,e,n),t.beginPath(),t.rect(e+this.padding,s+this.padding,n-this.padding-1,i-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=d.getTag(r.TAGS.UNITS),w=d.getTag("aligned"),v=(0,b.py)(u),T=d.getTag("separator")??"",E=n/5,I=C.Cn.getOrCreate(d).getSplitter(E),N=f["reference-sequence"],L=f["current-word"],_=I(null!=N&&""!=N?N:L??""),R=I(h);let O=M,k=p.classic;w&&w.includes("MSA")&&y==b.r2.SEPARATOR&&(k=p.MSA);for(const[r,l]of a().enumerate(R)){O=v.get(r),t.fillStyle=M;const a=l===R.length-1;if(g(e+this.padding,s,n,i,t,r,O,0,!0,1,T,a,k,x,l,o,_,c,S._monomerLengthMap),m>n)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";Ve.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class I extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return S.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,n,i,o,a){const h=o.grid,c=o.cell,u=o.tableColumn,d=c.value??"",m=u.tags.separator,p=u.tags[r.TAGS.UNITS];n=A(h,t,e,n);const[g,f]=d.split("#"),y=(0,l.vU)(p,m);N(t,e,s,n,i,y(g),y(f),p)}}function N(t,e,s,n,i,r,o,l,h,c){if(r.length!==o.length){const t=function(t,e){let s=0,n=0;const i=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)i[t]===r[t]&&s++;const o=i.length-r.length;for(let t=i.length-1;t>o;t--)i[t]===r[t-o]&&n++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>n?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(r).toArray(),a()(o).toArray());r=t.subParts1,o=t.subParts2}const u=t.measureText(E(r).join("")),d=t.measureText(E(o).join("")),m=Math.max(u.width,d.width);h&&(n=m+4*r.length,t.canvas.width=m+4*r.length);let p=Math.max(e,e+(n-(m+4*r.length))/2)+5;const f=Math.max(s,s+(i-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?m+4*r.length:n,i),t.clip(),t.font="12px monospace",t.textBaseline="top";let y=w.UE.Color;"HELM"!=l&&(y=(0,b.py)(l.substring(l.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],l=y.get(s);if(s!=a){const r=y.get(a),o=g(p,f-7,n,i,t,s,l,0,!0),h=g(p,f+7,n,i,t,a,r,0,!0);p=Math.max(h,o),c&&(c[e]=L(s,a,l,r,f,7,i))}else p=g(p,f,n,i,t,s,l,0,!0,.5);p+=4}t.restore()}function L(t,e,s,n,i,r,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(E([t]).join("")).width,c=l.measureText(E([e]).join("")).width,u=Math.max(h,c);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",g(0,i-r,u,o,l,t,s,0,!0),g(0,i+r,u,o,l,e,n,0,!0),a}var _,R=s(701),O=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(_||(_={}));const k=new class{constructor(){this.regionTypes=[_.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=O.ES.Entropy}};var P=s(833);const G=_;var F,W;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(F||(F={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight"}(W||(W={}));const V=k;class H extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(W.skipEmptyPositions,V.skipEmptyPositions,{category:F.DATA}),this.regionTypes=this.stringList(W.regionTypes,V.regionTypes,{category:F.DATA,choices:Object.values(G).filter((t=>t!=G.Unknown))}),this.chains=this.stringList(W.chains,V.chains,{category:F.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(W.fitWidth,V.fitWidth,{category:F.LAYOUT}),this.positionWidth=this.float(W.positionWidth,V.positionWidth,{category:F.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(W.positionHeight,V.positionHeight,{category:F.LAYOUT,choices:Object.keys(O.ES)})}async init(){this.subs.push((0,R.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case W.regionTypes:case W.chains:this.setData(this.dataFrame,this.regions)}switch(t.name){case W.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case W.fitWidth:case W.positionWidth:this.calcSize();break;case W.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.positionWidth]:this.positionWidth});this.calcSize();break;default:this.setData(this.dataFrame,this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,Ve.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),Ve.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){Ve.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&i.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Ve.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),n=[];for(let t=0;t<s.length;t++)for(const i of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==i));n.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,i,e]})())}const r=await Promise.all(n);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=i.table(this.chains,(t=>[...s.length>0?[i.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",i.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=i.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",i.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=i.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Ve.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Ve.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,s=13,n=9,i=(this.root.clientWidth-t-(this.logos.length-1)*n-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[P.bo.positionWidth]:i-s.positionMarginValue}),s.root.style.width=i*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?O.Ct.Selected:O.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const n=this.chains[s];this.logos[e][n].setOptions({[P.bo.filterSource]:t})}}}var D=s(9017),B=s(7656),U=s(7983),Z=s(489);async function Y(t){const e=C.Cn.getOrCreate(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=Z.U.LEVENSHTEIN,n=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(b.r2.FASTA);n=t.toList(),s=C.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<n.length;e++)n[e]=t.seqCol.isNone(e)?null:n[e];const i=await(0,B.I)(n,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,i.embedding[e])));return{distance:i.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,U.HV)(t.seqCol,!1),await n.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function z(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var q=s(5697),X=s(3379),$=s.n(X),K=s(7795),j=s.n(K),J=s(569),Q=s.n(J),tt=s(3565),et=s.n(tt),st=s(9216),nt=s.n(st),it=s(4589),rt=s.n(it),ot=s(9414),at={};at.styleTagTransform=rt(),at.setAttributes=et(),at.insert=Q().bind(null,"head"),at.domAPI=j(),at.insertStyleElement=nt(),$()(ot.Z,at),ot.Z&&ot.Z.locals&&ot.Z.locals;var lt=s(3914),ht=s(6254);let ct=0;const ut="cliffsDf",dt=new R.Subject,mt="act_diff",pt="sali",gt="sim",ft="line_index",yt=["1_seq","2_seq"],bt="filterCliffs";function wt(t,e,s){const n=e.getBoundingClientRect(),i=t.clientX-n.left,r=t.clientY-n.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-i,t.a[1]-r)+Math.hypot(t.b[0]-i,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var Ct=s(1040);async function vt(t,e,s,i,o){e.version!==e.temp["last-invalidated-version"]&&await(0,U.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(i).init((t=>e.temp["monomeric-mols"].get(t))),await n.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:i,simArr:o})}function St(t){const e=i.divH([]),s=i.divV([i.divText(t.seqCol.name),i.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,n)=>{const r=i.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(i.divV([i.divText(t.seqCol.get(s)),r]))})),e}function Mt(t){const e=i.div();e.append(i.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);t.line.mols.forEach(((e,i)=>{s[i]=t.seqCol.get(e),n[i]=t.activityCol.get(e)}));const r={},o=C.Cn.getOrCreate(t.seqCol),a=o.getSplitter(),l=At(a(s[0]),a(s[1]),o.units,r);return e.append(i.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(Et(r)),e.append(Tt("Activity delta",Math.abs(n[0]-n[1]))),e.append(Tt("Cliff",t.sali)),e}function Tt(t,e){return i.divH([i.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),i.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function At(t,e,s,n){const i=document.createElement("canvas"),r=i.getContext("2d");return i.height=30,N(r,0,0,0,30,t,e,s,!0,n),i}function Et(t){const e=i.div();if(Object.keys(t).length>0){const s=i.divV([]);s.append(i.divH([i.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),i.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(i.divH([i.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function xt(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const n=t.plot.grid();return n.col(e[0]).visible=!1,n.col(e[1]).visible=!1,n}s(7861);var It=s(4004),Nt=s(7228),Lt=s(8601),_t=s(5226);s(9133);class Rt extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",q.kg[0],{choices:q.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(r.debounce(i.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(n.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Ot=s(7241),kt=s(4293),Pt=s(2669);async function Gt(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=C.Cn.getOrCreate(t).getDistanceFunctionName(),n=new Pt.m(!0,!1),i=await n.calc(e,s);return n.terminate(),i}function Ft(t){return(e,s)=>{const n=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?n(e,s):n(s,e)}}class Wt extends Rt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new R.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const i=s.plot.grid();i.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));i.cell("score",o).cell.value=null,n.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,kt.Y)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ot.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await n.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Gt(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const n=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const i=C.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),n.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(n.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*n.length/o),u=s===a.length-1?Math.floor((s+1)*n.length/o):n.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:n,max:i}})=>{t?o(t):(h=Math.min(h,n),c=Math.max(c,i),l.set(e,r),s())},t.postMessage({fnName:i,values:n,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,n=Ft(e),i=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[n(this.targetMoleculeIdx,s)]:1-t[s]})));i.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=i.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=i.div(),s={},r=this.molCol?.name,o=t.col(r),a=C.Cn.getOrCreate(o),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(r,t.currentRowIdx)),u=At(h,c,a.units,s);e.append(i.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(i.divV([i.divText("Different sequence length:",{style:{fontWeight:"bold"}}),i.divText(`target: ${h.length} monomers`),i.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(Et(s));const d=i.accordion(),m=i.element("i");m.className="grok-icon svg-icon svg-view-layout",d.addTitle(i.span([m,i.label("Similarity search")])),d.addPane("Differences",(()=>e),!0),n.shell.o=d.root}}var Vt=s(8518);class Ht extends Rt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new R.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([s]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]})),(0,kt.Y)(this.root,n.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ot.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await n.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Gt(this.moleculeColumn),e=this.moleculeColumn.length,s=Ft(e);this.renderMolIds=(0,Vt.L)(e,Math.min(e,this.limit),((e,n)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(n)?0:t[s(e,n)]))}}var Dt=s(9943),Bt=s(4413),Ut=s(1061),Zt=s(5490),Yt=s(116);const zt={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class qt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=i.inputs([]),this.methodsParams={[Yt.AL.UMAP]:new Yt.bD,[Yt.AL.T_SNE]:new Yt.aP},this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=i.columnInput(zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=i.choiceInput("Method",Yt.AL.UMAP,[Yt.AL.UMAP,Yt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=i.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):i.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=i.inputs([]);let e=!1;this.similarityMetricInput=i.choiceInput("Similarity",Ct.gk.Tanimoto,q.Rt)}createAlgorithmSettingsDiv(t,e){return i.empty(t),Object.keys(e).forEach((s=>{const n=e[s],r=i.floatInput(n.uiName,n.value,(()=>{n.value=r.value}));i.tooltip.bind(r.root,n.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=i.columnInput(zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),i.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Xt extends qt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=i.boolInput("Plot Embeddings",!0),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class $t extends qt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=i.intInput("Similarity cutoff",80),i.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),i.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Kt,jt=s(8457);async function Jt(t,e,s,n){const i=(0,jt.O)(e),o=(0,l.vU)(e.getTag(r.TAGS.UNITS),e.getTag("separator"))(s),a=n===Kt.IDENTITY?function(t,e){const s=e.columns.length,n=new Array(s),i=new Array(s),o=new Array(s);for(let r=0;r<s;++r){const s=e.columns.byIndex(r);n[r]=s.getRawData(),i[r]=s.categories.indexOf(""),o[r]=s.categories.indexOf(t[r]??"")}const a=r.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)n[e][s]===o[e]&&++l[s];l[s]/=t.length}return a}(o,i):n===Kt.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,Nt.Qx)(s,t)}(o,i):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${n}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(Kt||(Kt={}));var Qt,te=function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?i(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((n=n.apply(t,e||[])).next())}))};class ee{constructor(t,e,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._stopStartBtn=i.button(i.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=i.button(i.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=i.button(i.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._closeBtn=i.button(i.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,ee.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=i.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(i.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=i.iconFA("clock");this._isAutomatic||0===e&&(s=i.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=i.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=i.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=i.divH([s,n],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;n.shell.windows.showContextPanel=!0,n.shell.windows.showHelp=!1;const i=Array.from(n.shell.dockManager.rootNode.children)[0];this._node=n.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,i,""),(null===(e=null===(t=i.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=i.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return te(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,n,a),yield(0,Ut.gw)(a));const l=i.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=i.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return te(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return te(this,void 0,void 0,(function*(){const n=i.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);n.append(o),t.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){n.shell.dockManager.close(this._node),n.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){n.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ee.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return te(this,void 0,void 0,(function*(){this._initRoot(),n.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function se(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),Ve.logger.error(t.message,void 0,s)}ee.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Qt||(Qt={}));const ne="data/sample_FASTA_PT_activity.csv";var ie=s(1811);async function re(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function oe(){return await n.functions.call("Dendrogram:getDendrogramService",{})}const ae="data/sample_FASTA_PT_activity.csv",le="sequence";var he=s(3336),ce=s.n(he);const ue="data/sample_FASTA_PT_activity.csv";var de=s(8341);const me="samples/HELM.csv";var pe=s(2568),ge=s(525);class fe{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=n.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Ve.name}.${this.funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case P.bo.fixWidth:case P.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ye{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=i.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=i.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=i.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var be=s(9416);class we{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const Ce=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},ve={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class Se{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new we(He().getBioLib()).getCappedRotatedMonomer(a,o),h=i.div(o),c=l?n.chem.svgMol(l,void 0,void 0,ve):null,u=t.grid.canvas.getBoundingClientRect(),d=t.bounds.right+u.left-4,m=t.bounds.bottom+u.top-4;return i.tooltip.show(i.divV([h,...c?[c]:[]]),d,m),!0}static getOrCreate(t){let e=t.temp[Ce.tooltipHandlerTemp];return e||(e=t.temp[Ce.tooltipHandlerTemp]=new Se(t)),e}}class Me extends r.GridCellRenderer{get name(){return S.Of.MONOMER}get cellType(){return S.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,n,i,r,o){if(r.gridRow<0)return;Se.getOrCreate(r.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,b.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,b.GU)(l,6),e+n/2,s+i/2,n)}}class Te extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new R.Subject}}class Ae extends r.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(t){this._properties=t}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),this.logger.error(e,void 0,s)}}class Ee extends r.Widget{constructor(t){super(i.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=i.intInput("Max monomer length",Ve.properties.MaxMonomerLength,(t=>{Ve.properties.MaxMonomerLength=t})),e=i.boolInput("Tooltip WebLogo",Ve.properties.TooltipWebLogo,(t=>{Ve.properties.TooltipWebLogo=t})),s=i.choiceInput("Default Separator",Ve.properties.DefaultSeparator,[".","/","-"],(t=>{Ve.properties.DefaultSeparator=t}));this.root.appendChild(i.form([t,e,s]))}}var xe=s(5362),Ie={};Ie.styleTagTransform=rt(),Ie.setAttributes=et(),Ie.insert=Q().bind(null,"head"),Ie.domAPI=j(),Ie.insertStyleElement=nt(),$()(xe.Z,Ie),xe.Z&&xe.Z.locals&&xe.Z.locals;class Ne extends r.Widget{constructor(t){super(i.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=C.Cn.getOrCreate(this.seqCol),e=Ve.properties.TooltipWebLogo,s=this.seqCol.getTag(O.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Le="PEPTIDE1{",_e="}$$$$",Re="<All>";function Oe(t){t.setTag("quality",r.SEMTYPE.MACROMOLECULE),t.setTag("aligned","SEQ"),t.setTag("alphabet","PT")}async function ke(t,e,s,i){function o(t){const e=t.replace(Le,"").replace(_e,"").split("."),n=e.findIndex((t=>t===s)),r=e.findIndex(((t,e)=>t===i&&e>n));return[n+1,r+1]}const a=t.dataFrame,l=C.Cn.getOrCreate(t).convert(b.r2.HELM).toList().map((t=>function(t){return"R3-R3"===e?function(t){return function(t,e,s){return e===Re||s===Re||o(t).every((t=>t>0))}(t,s,i)?function(t,e){return t.replace(_e,`}$PEPTIDE1,PEPTIDE1,${e[0]}:R3-${e[1]}:R3${"$".repeat(6)}`)}(t,o(t)):t}(t):function(t){return function(t,e,s){return e===Re||s===Re||t.includes(Le+e)&&t.includes(s+_e)}(t,s,i)?function(t,e){return t.replace(_e,`}$PEPTIDE1,PEPTIDE1,${e[1]}:R2-${e[0]}:R1${"$".repeat(6)}`)}(t,function(t){return[1,t.replace(Le,"").replace(_e,"").split(".").length]}(t)):t}(t)}(t))),h=a.columns.getUnusedName("Cyclization("+t.name+")"),c=r.Column.fromList("string",h,l);Oe(c),c.setTag("units",b.r2.HELM),c.setTag("cell.renderer","helm"),a.columns.add(c),await n.data.detectSemanticTypes(a)}function Pe(t,e,s,n){const i=C.Cn.getOrCreate(t);let r=null,o=null;for(let t=0;t<i.posList.length;++t)i.posList[t]==e&&(r=t),i.posList[t]==s&&(o=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===o&&null!==s)throw new Error(`End position ${s} not found.`);if(i.posList.length<o)throw new Error(`End position ${o} exceeds positions length`);const a=n||`${t.name}: (${e??""}-${s??""})`;return i.getRegion(r,o,a)}const Ge={df:r.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(b.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Fe{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??Ge;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(".positionNames",this.data.positionNames),this.data.regions&&e.setTag(".regions",JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await n.data.detectSemanticTypes(this.data.df),this.view=n.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Ve.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class We{constructor(t){this.call=t,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const e=t=>this.call.inputParams[t].property.description;this.inputs.table=i.tableInput("Table",this.call.inputParams.table.value??n.shell.tv.dataFrame,void 0,(()=>{}));const s=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),o={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.inputs.sequence=i.columnInput("Sequence",n.shell.tv.dataFrame,s,this.sequenceInputChanged.bind(this),o),this.inputs.start=i.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=i.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=i.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=i.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const t in this.call.inputParams)i.tooltip.bind(this.inputs[t].captionLabel,e(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&C.Cn.getOrCreate(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=C.Cn.getOrCreate(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?C.Cn.getOrCreate(t):null,s=this.inputs.start.input,n=this.inputs.end.input;for(let t=s.options.length-1;t>=0;--t)s.options.remove(t);for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),i=document.createElement("option");e.text=i.text=t,e.value=i.value=t,s.options.add(e),n.options.add(i)}s.value=e?.posList[0]??"",n.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(".regions"):null,s=e?JSON.parse(e):null,n=this.inputs.region.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);const i=document.createElement("option");if(i.text="",i.value=JSON.stringify(null),n.options.add(i),null!=s){this.inputs.region.root.style.removeProperty("display");for(const t of s){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),n.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",s=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let n=t.options.length-1;n>=0;--n){const i=t.options[n],r=JSON.parse(i.value);r&&e===r.start&&s===r.end&&(t.selectedIndex=n)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,s=this.inputs.sequence.value,n=this.inputs.start.stringValue??"",i=this.inputs.end.stringValue??"";return null!=e?`${s.name}(${e.name}): ${e.start}-${e.end}`:`${s?.name}: (${n}-${i})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=i.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});i.dialog({title:"Get Region"}).add(t).onOK((async()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Ve.handleErrorUI(t)}))})).show()}widget(){const t=i.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=i.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Ve.handleErrorUI(t)}))}));return r.Widget.fromRoot(i.divV([t,i.div(e)]))}}const Ve=new Ae;function He(){return Zt.NT.instance}let De=null;class Be{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Ue(){const t=await n.functions.call("Chem:getRdKitModule");await Promise.all([(async()=>{await Zt.NT.instance.loadLibraries()})(),(async()=>{const t=await Ve.getProperties(),e=new Te(t);Ve.properties=e})()]).finally((()=>{Ve.completeInit()}));const e=Zt.NT.instance.getBioLib(),s=[],i=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const n=r[e].replaceAll("#R","O "),o=t.get_mol(n),a=JSON.parse(o.get_descriptors()).CrippenClogP;i.push(a),o?.delete()}));const o=i.reduce(((t,e)=>t+e),0)/i.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=i[t]<o?"#4682B4":"#DC143C";De=new Be(a)}function Ze(t){const e=new Ne(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();n.shell.error(e)})),e}function Ye(){return Zt.NT.instance.getBioLib()}function ze(t){const e="getRegionTopMenu",s=r.Func.find({package:Ve.name,name:e});if(1!==s.length)throw new Error(`Package '${Ve.name}' func '${e}' not found`);const n=s[0].prepare({table:t.dataFrame,sequence:t});return new We(n).widget()}async function qe(t){return(0,Zt.cf)()}function Xe(t){try{new We(t).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(`Get region editor error: ${e}`),Ve.logger.error(e,void 0,s)}}function $e(t){const e=new ye;i.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Ke(t){const e=new Xt(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function je(t){const e=new $t(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function Je(t){const e=new Ee(t);return e.init().then(),e}function Qe(){return new x}function ts(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=i.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:f.short,[f.short,f.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const n=parseInt(t.getTag(m.maxMonomerLength)),o=i.intInput("Max monomer length",isNaN(n)?Ve.properties.MaxMonomerLength:n,(e=>{t.setTag(m.maxMonomerLength,e.toString()),t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));o.setTooltip(`The max length of monomer name displayed without shortening in '${f.short}' monomer width mode.`);const a=i.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));a.setTooltip("The size of margin between monomers (in pixels)");const l=i.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Color code");const h=i.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const c=i.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));c.setTooltip('When on, all sequences get rendered in the "diff" mode');const u=i.inputs([s,o,a,h,l,c]);return new r.Widget(u)}(t)}function es(t){return function(t){const e=i.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let n=w.UE.Color;switch(s){case"DNA":case"RNA":n=(0,b.py)("DNA");break;case"PT":n=(0,b.py)("PT")}const o=new Map;let l=0;const h=C.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},d=Array.from(o.entries());d.sort(((t,e)=>e[1]-t[1])),d.forEach((([t,e])=>{const s=e/c,r=n.get(t),o=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/l*50+"px";const a=i.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,u[t]=i.div([o,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const m=i.tableFromMap(u);return Array.from(m.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(m),new r.Widget(e)}(t)}function ss(){return new x}function ns(){return new I}function is(t,e,s,n,i){const r=new D.k(n,i,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function rs(){return new P.OZ}function os(){return new H}function as(t,e,s,n){return Pe(t,e??null,s??null,n??null)}async function ls(t,e,s,i,r){const o=Pe(e,s??null,i??null,r??null);e.dataFrame.columns.add(o),await n.data.detectSemanticTypes(e.dataFrame)}async function hs(t,e,o,a,l,h){if(!(0,pe.n)(e,"Activity Cliffs"))return;const c=z(t),u={units:e.getTag(r.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},d=C.Cn.getOrCreate(e);let m=Ct.gk.Tanimoto,p=e;if(d.isFasta()||d.isSeparator()&&d.alphabet&&"UN"!==d.alphabet)if(d.isFasta())m=d.getDistanceFunctionName();else{p=d.convert(b.r2.FASTA);const t=C.Cn.getOrCreate(p);m=t.getDistanceFunctionName(),u.units=b.r2.FASTA}const g=async()=>await async function(t,e,o,a,l,h,c,u,d,m,p,g,f,y,b,w,C,v){ct++;const S=c/100,M=o??e;let T=!1,A=!1;const E={};let x,I;const N={seqCol:M,methodName:d,similarityMetric:u,embedAxesNames:a,options:C},{distance:L,coordinates:_}=await g(N);for(const e of _)t.columns.add(e);let R=L;const O=Object.values(Z.U).map((t=>t.toString())).includes(u);O&&!L&&(R=lt.H.calc(e.toList(),Z.o[u]()).data);const k=function(t,e,s){const n=[],i=[],r=[],o=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const 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e=0;e<t.rowCount;e++)s.includes(n[e])&&(t.rows.removeAt(e-r),i.push(e),r+=1);return i}(c,e),d={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},m=s===Yt.AL.UMAP?1e5:15e3,p=s===Yt.AL.UMAP?5e3:2e3;if(t.rowCount>m)n.shell.warning(`Too many rows, maximum for sequence space is ${m}`);else{if(!(t.rowCount>p))return g(await Y(d));i.dialog().add(i.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running Sequence space..."),e=await Y(d);return t.close(),g(e)})).show()}function g(e){const s=e.coordinates;for(const e of s){const s=e.toList();u.forEach((t=>s.splice(t,0,null))),t.columns.add(r.Column.float(e.name,t.rowCount).init((t=>s[t])))}if(a)return n.shell.tableView(t.name).scatterPlot({x:h[0],y:h[1],title:"Sequence space"})}}async function us(t,e){if(0===r.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void n.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,pe.n)(e,"To Atomic Level"))return;const s=(await He()).getBioLib(),o=await(0,Lt.i0)(t,e,s);null!==o.col&&(t.columns.add(o.col,!0),await n.data.detectSemanticTypes(t)),o.warnings&&o.warnings.length>0&&n.shell.warning(i.list(o.warnings))}function ds(){(0,ge.K)()}async function ms(t=null,e=null){return(0,ge.K)({col:t,clustersCol:e})}async function ps(){const t=n.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(C.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,pe.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});n.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),n=e.find((t=>C.Cn.getOrCreate(t).isMsa())),r=i.choiceInput("Column",n?n.name:t[0],t);i.dialog({title:"Composition 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instanceof Error?t.message:t.toString()})}finally{i+=1,e.update(100*i/s.length,`Test ${a.fileName}`)}n.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=r.DataFrame.fromObjects(o);return a.name=`datasets_detectMacromolecule_${t}`,a}async function Cs(t,e){await(0,be.n)(t,e)}function vs(t){const e=C.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function Ss(){return new Wt}function Ms(){const t=n.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Ts(){return new Ht}function As(){const t=n.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Es(t){const e=(0,kt.B)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new U.uH(e)}function xs(t){n.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),n.shell.tv.grid.scrollToCell(t,0)}async function Is(t,e,s){return Jt(t,e,s,Kt.IDENTITY)}async function Ns(t,e,s){return Jt(t,e,s,Kt.SIMILARITY)}function Ls(){(0,Dt.C2)()}function _s(){return new Bt.ST}async function Rs(){const t=r.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new fe(t,"webLogoLargeApp"),s=await Ve.files.readCsv("data/sample_PT_100000x5.csv");await n.data.detectSemanticTypes(s),await e.init(s)}finally{t.close()}}async function Os(){const t=r.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new Fe(t,"getRegionApp");await e.init()}finally{t.close()}}async function ks(){const t=r.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await Ve.files.readCsv("data/sample_HELM_empty_vals.csv"),s=new Fe(t,"getRegionHelmApp");await s.init({df:e,colName:"HELM"})}finally{t.close()}}function Ps(t,e){!function(t,e){const s=C.Cn.getOrCreate(t.column),i=Object.values(b.r2).filter((t=>t!==s.units));e.group("Copy").items(i,(e=>{const s=C.Cn.getOrCreate(t.column),i=e===b.r2.SEPARATOR?Ve.properties.DefaultSeparator:void 0,r=s.getConverter(e,i)(t.value);navigator.clipboard?(navigator.clipboard.writeText(r),n.shell.info(`Value of notation '${e}' copied to clipboard`)):n.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function Gs(){await async function(){let t,e;try{const s=new ee("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await Ve.files.readCsv(ne),t=n.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,r.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){se(t)}}()}async function Fs(){await async function(){let t,e,s,i,o;try{const a=new ee("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[i,t,e]=await Promise.all([Ve.files.readCsv(ae),re(),oe()]),s=n.shell.addTableView(i),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,n){let i;{const t=Object.values(Qt);for(let s=0;s<t.length;s++){const n=t[s];if(!e.col(n)){const i=s==t.length-1;e.columns.add(r.Column.float(n,e.rowCount),i)}}if(e.rowCount>=1){const n=e.getCol(s).toList(),i=Date.now();Ve.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,B.I)(n,"UMAP",Ct.W.Levenshtein,{}),o=Date.now();Ve.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-i)/1e3} s`);for(let s=0;s<t.length;s++){const n=t[s],i=e.getCol(n),o=r.embedding[s];i.init((t=>o[t]))}const a=Date.now();Ve.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}i=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Qt.X,yColumnName:Qt.Y,lassoTool:!0})}return t.dockManager.dock(i,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(s,i,le)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const n=i.getCol(le).toList(),r=lt.H.calc(n,((t,e)=>ie.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=i.getCol("sequence_id");i.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){se(t)}}()}async function Ws(){await async function(){let t,e,s,i,o;const a=Yt.AL.UMAP;try{const l=new ee("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([Ve.files.readCsv(ue),re(),oe()]),i=n.shell.addTableView(s),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await hs(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),i.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),ce()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const n=s.getCol("sequence").toList(),r=lt.H.calc(n,((t,e)=>ie.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(i.grid,o,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){se(t)}}()}async function Vs(){await async function(){const t="HELM";let e,s,o;try{await new ee("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await Ve.files.readCsv("samples/HELM.csv"),s=n.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const n=s.grid.columns.byIndex(e);[t,"Activity"].includes(n.name)||(n.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await us(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const n=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(n),o=i.dialog().add(a).show(),await(0,Ut.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){se(t)}}()}async function Hs(){await async function(){let t,e,s,i,o,a;const l="msa(HELM)",h=Yt.AL.UMAP;try{const c=new ee("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=n.shell.addTableView(e=await Ve.files.readCsv(me)),n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=de.J[0];i=await(0,de.f)(s,l,t,1.53,0,void 0),e.columns.add(i),await n.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await cs(e,i,h,Z.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){se(t)}}()}async function Ds(t,e){var s;Oe(s=e),s.setTag("units",b.r2.SEPARATOR),s.setTag("separator","-"),await n.data.detectSemanticTypes(t)}function Bs(t){return function(t){function e(){console.log("hi from update:"),l.value===a[0]?(console.log("hi from first branch:"),c=[Re].concat(h.getMonomerSymbolsByType("PEPTIDE"))):l.value===a[1]&&(c=[Re].concat(h.getMonomerSymbolsByRGroup(3,"PEPTIDE")),console.log("hi from second branch:")),u=i.choiceInput("R1:",c[0],c),d=i.choiceInput("R2:",c[0],c),i.empty(m),[u,d].forEach((t=>{m.appendChild(t.root)}))}const s=new R.Subject;s.subscribe((()=>e()));const n=["Cyclization"],o=i.choiceInput("Modification",n[0],n),a=["N-O","R3-R3"],l=i.choiceInput("Type",a[0],a,(()=>{s.next()})),h=Zt.NT.instance.getBioLib();let c=[],u=i.choiceInput("R1:",c[0],c),d=i.choiceInput("R2:",c[0],c);const m=i.divV([u.root,d.root]);e();const p=i.bigButton("Run",(async()=>ke(t,l.value,u.value,d.value))),g=i.div([o,l,m,p]);return new r.Widget(g)}(t)}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class n{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class i{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",n="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,n=this.seq2.substr((e-1)*this.step,this.step)+n):this.dpGrid[t][e].parentJ==e?(n=r+n,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,n=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+n:r+n);const i=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[i][e].parentJ}return new i(s,n,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let n=1;n<=this.len1;n++)for(let i=1;i<=this.len2;i++)this.fillOne(n,i),this.dpGrid[n][i].value<=0?(this.dpGrid[n][i].value=0,this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0):0==this.dpGrid[this.dpGrid[n][i].parentI][this.dpGrid[n][i].parentJ].value&&(this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0),this.dpGrid[n][i].value>t&&(t=this.dpGrid[n][i].value,e=n,s=i);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,n=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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t=n.shell.tv.dataFrame,e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.columnsInput=i.columnInput("Column",t,this.col,(t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()}),e),this.substructureInput=i.stringInput("Substructure",""),this.editHelmLink=i.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const s=r.DataFrame.create(1);s.columns.addNewString(c).init((t=>"")),s.col(c).semType=this.col.semType,s.col(c).setTag(r.TAGS.UNITS,h.r2.HELM),this.grid=s.plot.grid(),this.separatorInput=i.stringInput("Separator",this.separator),this.inputsDiv=i.div(),this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator"),this.updateInputs(),this.dialog=i.dialog("Substructure Search").add(i.divV([i.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,e=this.units===h.r2.HELM?s.get(c,0):this.substructureInput.value;this.units===h.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(e=e.replaceAll(this.separatorInput.value,this.separator)),t=this.units===h.r2.HELM?await m(e,this.col):d(e,this.col),this.col.dataFrame.filter.and(t)})).show()}}function d(t,e,s){const n=s?function(t,e){const s=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),n=t.charAt(0)===e,i=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${s}|${s}$`,"g"),"");return n?i?`${s}${r}${s}`:`${s}${r}${s}|${s}${r}$`:i?`^${r}${s}|${s}${r}${s}`:`^${r}${s}|${s}${r}${s}|${s}${r}$`}(t,s):t,i=r.BitSet.create(e.length);for(let s=0;s<e.length;s++){const r=e.get(s);(r.match(n)||r===t)&&i.set(s,!0,!1)}return i}async function m(t,e){e.version!==e.temp["last-invalidated-version"]&&await p(e,!0);const s=r.Column.string("helm",1).init((e=>t));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,h.r2.HELM);const i=await(0,o.D)(s,!0,e.temp["monomers-dict"]);return(await n.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:i.get(0),molBlockFailover:""})).get(0)}async function p(t,e){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const n=new Map,i=await(0,o.D)(t,e,n);t.temp["monomeric-mols"]=i,t.temp["monomers-dict"]=n,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>o});var n=s(4469),i=s(976),r=s(499);function o(t,e,s=[],o=[],a=!0){const[l,h]=function(t,e,s=[],o=[]){let a=!0,l="";const h=r.Cn.getOrCreate(t);if(t.semType!==i.SEMTYPE.MACROMOLECULE)n.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;o.length>0&&!o.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,o);return a&&!l&&n.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>r,WY:()=>h,jB:()=>c,rs:()=>a});var n,i,r,o,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(n||(n={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(i||(i={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(o||(o={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>d});var n=s(976),i=s(3870),r=s(4469),o=s(3336),a=s.n(o),l=s(8447),h=s(499);let c=null,u=[];function d(t){let e=t??r.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=h.Cn.getOrCreate(e),o=s.notation;const d=i.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),m=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=i.columnInput("Column",r.shell.t,e,(t=>{t.semType===n.SEMTYPE.MACROMOLECULE?(e=t,s=h.Cn.getOrCreate(e),o=s.notation,o===l.r2.HELM&&(y.value="/"),d.textContent="Current notation: "+o,f=m.filter((t=>t!==o)),w=i.choiceInput("Convert to",f[0],f,b),b(),c?.clear(),c?.add(i.div([d,p.root,w.root,y.root]))):p.value=e})),g=["-",".","/"];let f=m.filter((t=>t!==o));const y=i.choiceInput("Separator",g[0],g),b=()=>{w.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let w=i.choiceInput("Convert to",f[0],f,b);b(),w.onChanged((()=>{b()})),null==c&&(c=i.dialog("Convert Sequence Notation").add(i.div([d,p.root,w.root,y.root])).onOK((async()=>{const t=w.value,s=y.value??void 0;await async function(t,e,s){const n=h.Cn.getOrCreate(t).convert(e,s);t.dataFrame.columns.add(n);const i=await r.functions.call("Bio:detectMacromolecule",{col:n});return i&&(n.semType=i),await r.data.detectSemanticTypes(t.dataFrame),n}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},5490:(t,e,s)=>{"use strict";s.d(e,{NT:()=>T,cf:()=>S});var n,i=s(4469),r=s(3870),o=s(976),a=s(701);class l{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let s=t;const n=this.isWhitespace(s)?e:e-1;for(let t=0;t<n;t++)s=this.getNextColumnIdx(s);return s}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let s=this.getAtomBlockIdx();for(let n=0;n<t;n++)s=this.shiftIdxToAtomType(s),e[n]=this.parseAtomType(s),s=this.getNextLineIdx(s);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),s=new Float32Array(this.atomCount);let n=this.getAtomBlockIdx();for(let i=0;i<this.atomCount;i++){n=this.shiftIdxToXColumn(n);for(const r of[t,e,s])r[i]=this.parseFloatValue(n),n=this.getNextColumnIdx(n);n=this.getNextLineIdx(n)}return{x:t,y:e,z:s}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let s=0;s<this.bondCount;s++){e=this.shiftIdxToBondedAtomsPair(e);const n=new Uint16Array(2);n[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),n[1]=this.parseIntValue(e),t[s]=n,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let s=this.getBondBlockIdx();for(let n=0;n<t;n++)s=this.shiftIdxToBondType(s),e[n]=this.parseIntValue(s),s=this.getNextLineIdx(s);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let s=e+1;for(;!this.isWhitespace(s);)++s;return t(this.fileContent.substring(e,s))}}class h extends l{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,s=e;return this.isQuote(e)?(s=this.getNextIdenticalChar(e),e++):s=this.fileContent.indexOf(" ",s),this.fileContent.substring(e,s)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((s=this.fileContent.charCodeAt(e+1))>64&&s<91||s>96&&s<123);var s}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let s=this.getAtomBlockIdx();for(let n=0;n<e;n++){if(s=this.shiftIdxToAtomType(s),t(this.fileContent.charCodeAt(s),s))return!0;s=this.getNextLineIdx(s)}return!1}}!function(t){t.HEADER="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t.RGP_LINE="M RGP",t.A_LINE="A ",t.END="M END"}(n||(n={}));class c extends h{constructor(t){super(t)}static validate(t){return-1!==t.indexOf(n.HEADER)&&-1!==t.indexOf(n.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,n.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<n.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,n.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,n.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+n.NUM_OF_COUNTS_DIGITS;const s=parseInt(this.fileContent.substring(t,e));return t=e,e+=n.NUM_OF_COUNTS_DIGITS,{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class u extends h{constructor(t){super(t),this.init(t)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static validate(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const s=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class d{constructor(){}static getInstance(t){if(c.validate(t))return new c(t);if(u.validate(t))return new u(t);throw new Error("Malformed molfile")}}var m=s(7228),p=s(2397);const g="Libraries",f="System:AppData/Bio/libraries/";async function y(){return await Promise.all((await i.dapi.files.list(f,!0,"")).map((async t=>t.fullPath.substring(f.length))))}let b=Promise.resolve();async function w(){let t;return b=b.then((async()=>{const e=await i.dapi.userDataStorage.getValue(g,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await b,t}async function C(t){b=b.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await i.dapi.userDataStorage.postValue(g,"Settings",JSON.stringify(t),!0)})),await b}async function v(){const t=r.dialog({title:"Manage files"}).add(r.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function S(){const t=r.button("Manage",v),e=r.inputs([]),s=await y(),n=await w();for(const t of s){const s=r.boolInput(t,!n.exclude.includes(t),(()=>{1==s.value?n.exclude=n.exclude.filter((e=>e!=t)):n.exclude.includes(t)||n.exclude.push(t),C(n).then((async()=>{await T.instance.loadLibraries(!0),i.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new o.Widget(r.divV([e,r.div(t)]))}class M{constructor(t,e){this._monomers={},this._onChanged=new a.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}getMonomerSymbolsByRGroup(t,e,s){let n=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return n=n.filter((t=>null!==t)),0===n.length?[]:(n=n.filter((e=>{if(!e?.rgroups)return!1;console.log("monomer symbol:",e.symbol);let s=e?.rgroups.length>=t;console.log(`has rGroupNumber ${t}`,s);const n=d.getInstance(e.molfile);console.log(n.atomTypes);const i=n.atomTypes.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t));return console.log("rGroup indices",i),console.log(n.pairsOfBondedAtoms),s&&(s=!0),console.log("criterion",s),s})),n.map((t=>t?.symbol)))}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class T{constructor(){this._monomerLib=new M({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([y(),w()]),n=e.filter((t=>!s.exclude.includes(t))),i=await Promise.all(n.map((t=>this.readLibrary(f,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new M({},s)})))));this._monomerLib.updateLibs(i,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;i.shell.warning(e);const s=t instanceof Error?t.stack:void 0;p._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,n,r=[];const a=new o.FileSource(t);if(e.endsWith(".sdf"))1===o.Func.find({package:"Chem",name:"importSdf"}).length?(s=await a.readAsBytes(e),n=await i.functions.call("Chem:importSdf",{bytes:s}),r=(0,m.Xk)(n[0])):i.shell.warning("Chem package is not installed");else if(e.endsWith(".json")){const t=await a.readAsText(e);r=JSON.parse(t)}else{if(!e.endsWith(".csv"))throw new Error("Monomer library of unknown file format, supported formats: SDF, JSON, CSV");{const t=(l=await a.readCsv(e),Array.from({length:l.rowCount},((t,e)=>l.columns.names().reduce(((t,s)=>(t[s]=l.get(s,e),t)),{}))));if(!(0,m.eD)(t))throw new Error("Invalid format of CSV monomer lib");r=(0,m.Z)(t)}}var l;const h={},c=[];return r.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new M(h)}static get instance(){return T._instance||(T._instance=new T),T._instance}}T._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>I});var n=s(4469),i=s(976),r=s(3870),o=s(8447),a=s(499),l=s(6098),h=s(8341),c=s(2568),u=s(3553),d=s(2397),m=s(3379),p=s.n(m),g=s(7795),f=s.n(g),y=s(569),b=s.n(y),w=s(3565),C=s.n(w),v=s(9216),S=s.n(v),M=s(4589),T=s.n(M),A=s(9564),E={};E.styleTagTransform=T(),E.setAttributes=C(),E.insert=b().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),p()(A.Z,E),A.Z&&A.Z.locals&&A.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async 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n=["NH2","COOH"];if(t.startsWith(n[0])){const s=n[0].length;(0,x.hu)("-"==t[s],`Wrong sequence format: ${n[0]} without following '-' in '${t}'.`),e=s}if(t.endsWith(n[1])){const e=n[1].length+1;(0,x.hu)("-"==t[s-e],`Wrong sequence format: ${n[1]} without '-' precending in '${t}'.`),s-=e}return t.substring(e,s)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return N._dropDefises(N._truncateSequence(t))}encode(t){const e=t.length,s=new Array(e).fill(0);for(let n=0;n<e;++n){const e=t[n];(0,x.hu)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),s[n]=this.encodeLettter(e)}return s}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let s=0;s<t.length;++s){const n=t[s];(0,x.hu)(n in this.num2aa,`Unknown code '${n}' found in vector '${t}'`),e+=this.num2aa[n]}return e}}var L=s(3553);const _="input.fa",R="result.fasta";function O(t){return t.reduce(((t,e,s)=>t+`>sample${s+1}\n${e}\n`),"")}async function k(t,e=!1,s="",r=null,o,a,l){let h=t.toList();e&&(h=h.map((t=>N.clean(t).replace(/\-/g,""))));const c=t.length;r??(r=n.Column.string("Clusters",c).init("0")),r.type!=n.COLUMN_TYPE.STRING&&(r=r.convertTo(n.TYPE.STRING)),r.compact();const u=r.categories,d=r.getRawData(),m=new Array(u.length),p=new Array(u.length);for(let t=0;t<c;++t){const e=d[t];(m[e]??(m[e]=[])).push(h[t]),(p[e]??(p[e]=[])).push(t)}const g=await new E(["base/1.0.0",{tool:"kalign",version:L.WY,reinit:!0}]),f=n.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(m[t]);await g.fs.writeFile(_,e);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,n=await g.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(n);const r=await g.cat(R);if(!r)throw new Error("kalign output no result");const h=new i.i(r).sequencesArray,c=p[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(n.TAGS.UNITS),b=t.getTag("alphabet");return f.setTag(n.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",b),f.semType=n.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var n=s(4469),i=s(976),r=s(8447),o=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const d=await n.dapi.docker.dockerContainers.filter("bio").first();if("started"!==d.status&&"checking"!==d.status)return n.log.warning("PepSeA container has not started yet"),null;const m=t.length;u??(u=i.Column.int("Clusters",m).init(0)),u.type!=i.COLUMN_TYPE.STRING&&(u=u.convertTo(i.TYPE.STRING));const p=u.categories,g=new Array(p.length);for(let e=0;e<m;++e){const s=u.get(e);if(""===s)continue;const n=p.indexOf(s),i=t.get(e);i&&(g[n]??(g[n]=[])).push({ID:e.toString(),HELM:i})}const f=new Array(m);for(const t of g){const e=(await c(d.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(o.rs.SEPARATOR)}const y=i.Column.fromStrings(e,f);return y.setTag(i.TAGS.UNITS,r.r2.SEPARATOR),y.setTag("separator",o.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=i.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,i,r){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${i}&gap_extend=${r}`,l=await n.dapi.docker.dockerContainers.request(t,a,o);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var n=s(976),i=s(3870),r=s(4469),o=s(6414),a=s.n(o),l=s(8447),h=s(499);const c=60;function u(){const t=r.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==n.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),o=s?[s.name]:[],u=i.multiChoiceInput("Seq id columns",o,e.map((t=>t.name))),m=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==n.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),p=m.length>0?m[0].name:[],g=i.choiceInput("Seq column",p,m.map((t=>t.name))),f=i.intInput("FASTA line width",c);i.dialog({title:"Save as FASTA"}).add(i.inputs([u,g,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=g.value?t.columns.byName(g.value).column:null,n=f.value??c;s||r.shell.warning("Seq column is mandatory to save as FASTA.");const i=function(t,e,s=c,n="\n"){const i=l.kB,r=[];for(let o=0;o<e.length;o++){const a=t.map((t=>t.get(o).toString())).join("|"),l=d(e.get(o),i,s);r.push(`>${a}${n}`);for(const t of l)r.push(`${t}${n}`)}return"".concat(...r)}(e,s,n),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(i)}`),o.setAttribute("download",`${t.dataFrame.name}.fasta`),o.click()})).show()}function d(t,e,s=c){const n=e(t);let i=0;const r=n.length,o=[];for(;i<r;){const t=a()(n).slice(i,i+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");o.push(e),i+=t.length}return o}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var n=s(4469),i=s(976),r=s(1061),o=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,r.gw)(10),!(0,o.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const n=s.columns.byIndex(t);n.semType=l.Of.MONOMER,n.setTag("alphabet",e.getTag("alphabet"));const i=100;let r=0;for(;h.columns.byName(n.name)&&r<i;)n.name=u(n.name),r++;h.columns.add(n)}await n.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++)s.columns.byIndex(t).setTag(i.TAGS.CELL_RENDERER,"Monomer");return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>r,Y:()=>o});var n=s(4469),i=s(976);function r(){const t=n.shell.t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);if(null!==t)return t;n.shell.error("Current table does not contain macromolecules")}function o(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>p,OZ:()=>C});var n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(701),h=s(499),c=s(8447),u=s(9298);function d(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?d(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var m,p,g=s(2397);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class f{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,n){this.pos=t,this.name=e,this._freqs=s??{},n?.rowCount&&(this.rowCount=n.rowCount),n?.sumForHeightCalc&&(this.sumForHeightCalc=n.sumForHeightCalc),n?.label&&(this._label=n.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new f),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,n])=>n.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,n,i,o,a,l,h,c){const d=i==u.ES.Entropy?n*(o-this.sumForHeightCalc)/o:n;let m=c*h+(n-d-1);const p=Object.entries(this._freqs).sort(((e,s)=>t(e[0])||t(s[0])?t(e[0])&&t(s[0])?0:t(e[0])?-1:1:s[1].count-e[1].count));for(const t of p){const n=t[1],i=d*n.count/this.rowCount;n.bounds=new r.Rect((e-s)*h*a,m,l*h,i),m+=i}}render(t,e,s,n,i,r){for(const[o,a]of Object.entries(this._freqs))if(!e(o)){const e=(0,c.GU)(o,5),l=a.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=r.get(o)??r.get("other"),t.textAlign="left",t.font=s;const u=t.measureText(e);t.setTransform(l.width/u.width,0,0,l.height/i,h,l.top),t.fillText(e,0,-n)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(m||(m={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const b=u.vS;var w;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(w||(w={}));class C extends r.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.renderLevelRequested=w.Freqs,this.viewerId=C.viewerCount,C.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,b.sequenceColumnName,{category:m.DATA}),this.startPositionName=this.string(p.startPositionName,b.startPositionName,{category:m.DATA}),this.endPositionName=this.string(p.endPositionName,b.endPositionName,{category:m.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,b.skipEmptySequences,{category:m.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,b.skipEmptyPositions,{category:m.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,b.shrinkEmptyTail,{category:m.DATA}),this.backgroundColor=this.int(p.backgroundColor,b.backgroundColor,{category:m.STYLE}),this.positionHeight=this.string(p.positionHeight,b.positionHeight,{category:m.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,b.positionWidth,{category:m.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,b.verticalAlignment,{category:m.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,b.horizontalAlignment,{category:m.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,b.fixWidth,{category:m.LAYOUT,userEditable:!1}),this.fitArea=this.bool(p.fitArea,b.fitArea,{category:m.LAYOUT}),this.minHeight=this.float(p.minHeight,b.minHeight,{category:m.LAYOUT}),this.maxHeight=this.float(p.maxHeight,b.maxHeight,{category:m.LAYOUT}),this.showPositionLabels=this.bool(p.showPositionLabels,b.showPositionLabels,{category:m.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,b.positionMarginState,{category:m.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:m.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,b.filterSource,{category:m.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=i.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=i.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){this.setDataInProgress||(this.setDataInProgress=!0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.setData() `),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView(),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.updateSeqCol()})).then((async()=>{this.viewed||(await this.buildView(),this.viewed=!0)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=i.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=i.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=i.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,i.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(w.Freqs,"buildView"),g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(w.Layout,"rootOnSizeChanged").then((()=>{}))}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(".positionNames"),n=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(c.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=n?n.split(c.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(w.Freqs,"updatePositions").then((()=>{}))}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t))}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,this.Length-1,0,this.Length-1),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${n}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+6}px`),this.host.style.width=`${this.host}px`;const i=e>n;if(this.setSliderVisibility(i),i){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=n*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,i=this.root.clientHeight/s,r=Math.max(1,Math.min(n,i));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=o>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:this.updateSeqCol();break;case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:case p.shrinkEmptyTail:case p.skipEmptyPositions:case p.positionHeight:this.updatePositions();break;case p.minHeight:case p.maxHeight:case p.positionWidth:case p.showPositionLabels:case p.fixWidth:case p.fitArea:case p.horizontalAlignment:case p.verticalAlignment:case p.positionMargin:case p.positionMarginState:this.render(w.Layout,`onPropertyChanged(${t.name})`).then((()=>{}));break;case p.backgroundColor:this.render(w.Render,`onPropertyChanged(${t.name})`).then((()=>{}))}}onTableAttached(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){if(this.setDataInProgress)return;g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.detach(), `);const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView(),this.viewed=!1),t()}))}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,n=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),i=this.positions[n];if(void 0===i)return[n,null,null];const r=i.getMonomerAt(s,t.y);return void 0===r?[n,null,null]:[n,r,i.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>{const e=this.unitsHandler.defaultGapSymbol;return!t.hasMonomer(e)||t.getFreq(e).count!==t.rowCount})).toArray())}render(t,e){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${t}, reason='${e}' )`);const s=()=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,n=this.dataFrame.rowCount,i=this.unitsHandler.splitted;for(let e=0;e<n;++e)if(s.get(e)){const s=i[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||this.unitsHandler.defaultGapSymbol;this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()},i=(t,e)=>{g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `),this.calcLayout(t);const s=this.canvas.height-e*t,i=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==i&&n.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(i);for(let n=Math.floor(this.slider.min);n<=Math.floor(this.slider.max);++n)n in this.positions?this.positions[n].calcScreen((t=>this.unitsHandler.isGap(t)),n,this.slider.min,s,this.positionHeight,r,this._positionWidthWithMargin,this._positionWidth,t,e):console.warn(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${n}`);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()},o=t=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const n=window.devicePixelRatio,o=this.showPositionLabels?12:0;if(t>=w.Freqs&&s(),0===this.positions.length)return;t>=w.Layout&&i(window.devicePixelRatio,o),this.Length,e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const a=10*n;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth*n-2?1:(this._positionWidth*n-2)/l;o>0&&function(t,e,s,n,i,r,o,a){for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=r[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-o)*n*e+i*e/2,0),t.fillText(a.label,0,1)}}(e,n,h,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(e,(t=>this.unitsHandler.isGap(t)),"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};return this.renderLevelRequested=Math.max(this.renderLevelRequested,t),new Promise(((t,e)=>{window.setTimeout((()=>{try{if(this.renderLevelRequested>w.None)try{o(this.renderLevelRequested)}finally{this.renderLevelRequested=w.None}}catch(t){e(t)}}),0)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(w.Layout,"sliderOnValuesChanged").then((()=>{}))}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(w.Freqs,"dataFrameFilterOnChanged").then((()=>{}))}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===u.Ct.Selected&&this.render(w.Freqs,"dataFrameSelectionOnChanged").then((()=>{}))}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,n=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(n,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,n,i){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=i.pos;(s<t.length?t[s]:null)===n&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),n=i.div([i.div(`${o}`),i.div(`${e} rows`)]);i.tooltip.show(n,s.x+16,s.y+16)}else i.tooltip.hide()}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[n,i]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&i){const t=this.positions[n],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,n,i,r){const o=e.splitted[n],a=r.pos<o.length?o[r.pos]:null;return a===i||""===a&&i===e.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.filter,e,i,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),n=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+n)}catch(t){const e=d(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+e)}}}C.residuesSet="nucleotides",C.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>p});var n=s(3870),i=s(976),r=s(4469),o=s(6414),a=s.n(o),l=s(7983),h=s(701),c=s(4293),u=s(8447),d=s(1061);const m=rxjs.operators;class p extends i.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=n.loader(),this.notation=void 0,this.root=n.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(i.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(i.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new b,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,m.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class g{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class f extends g{constructor(){super(),this.substructureInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return n.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class b extends g{constructor(){super(),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await n.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);n.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),n.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=n.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substrucrureSearch(t){n.setUpdateIndicator(this._filterPanel,!0),await(0,d.gw)(10);const e=await(0,l.QF)(this.substructure,t);return n.setUpdateIndicator(this._filterPanel,!1),e}}},9378:function(t,e,s){"use strict";var n=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var i=n(s(4517));function r(t,e){var s=function(s){return 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1
+ var bio;(()=>{var t={2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>i});var n=s(9976);class i extends n.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,i)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,i)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new i({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in i.aaSynonyms?i.aaSynonyms[t]:t;return super.get(e)}}i.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class r{static getPalette(t="grok"){switch(t){case"grok":return i.GrokGroups;case"lesk":return i.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",n="";for(const i of t)"("==i?e++:")"==i?e--:e?s+=i:n+=i;return isNaN(parseInt(s))?[n,s]:[n,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[n,i]=this.getInnerOuter(t);if(n=n.length>6?`${n.slice(0,3)}...`:n,i=i.length>6?`${i.slice(0,3)}...`:i,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,i,1]:[this.undefinedColor,n,i,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,i,2]:[this.undefinedColor,n,i,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,i,3]:[this.undefinedColor,n,i,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,i,4]:[this.undefinedColor,n,i,4]}return[this.undefinedColor,n,i,0]}}r.SemType="Aminoacids",r.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",r.undefinedColor="rgb(100,100,100)",r.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},r.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},r.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},r.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>c,Qx:()=>u,Xk:()=>h,Z:()=>l,eD:()=>a});var n=s(976),i=s(4469),r=s(1047),o=(s(499),s(8457));function a(t){return t.every((t=>"object"==typeof t&&Object.values(r.pn).every((e=>e in t&&"string"==typeof t[e]))))}function l(t){function e(t){const e=new RegExp("\\[r\\]","g");let s=0;return t.replace(e,(t=>(++s,`[${s}*]`)))}const s=[];return t.forEach((t=>{const i={...r.zh};Object.entries(r.pn).forEach((([e,s])=>{const n=t[s];i[e]=n}));let o="smiles";const a=t[r.pn[o]],l=e(a).replace("[1*]","[H:1]").replace("[2*]","[OH:2]");i[o]=l,o="rgroups",i[o]=r.Ei,o="molfile";const h=e(a),c=n.chem.convert(h,n.chem.Notation.Smiles,n.chem.Notation.MolBlock);i[o]=c.replace("M ISO","M RGP"),s.push(i)})),console.log("resultLib:",s),s}function h(t){const e=[];for(let s=0;s<t.rowCount;s++){const n={};Object.keys(r.K4).forEach((e=>{if("symbol"===e){const i=t.get(r.K4[e],s);n[e]="."===i?t.get(r.At,s):i}else if("rgroups"===e){const i=t.get(r.K4[e],s).split("\n"),o=[];i.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),n=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${n}][H]`:`O[*:${n}]`,e.alternateId="H"===s?`R${n}-H`:`R${n}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${n}`,o.push(e)})),n[e]=o}else r.K4[e]&&(n[e]=t.get(r.K4[e],s))})),e.push(n)}return e}async function c(){const t=n.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e){t instanceof n.Column&&(t=(0,o.O)(t).columns.toList());const s=(await c()).getBioLib(),r=new Array(t.length),a=t[0].length,l=new Float32Array(a);for(let o=0;o<t.length;++o){const h=e[o],c=s.getMonomer("PEPTIDE",h)?.smiles??"",u=t[o],m=u.getRawData(),d=u.categories,p=d.indexOf("");if(r[o]={categories:d,data:m,emptyIndex:p},void 0===h)continue;const g=n.Column.fromStrings("smiles",d.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(n.DataFrame.fromColumns([g]),(await i.chem.getSimilarities(g,c)).getRawData());for(let t=0;t<a;++t){const e=m[t];l[t]+=""!==h&&e!==p?f[e]:""===h&&e===p?1:0}}for(let s=0;s<l.length;++s){let i=l[s]/e.length;for(let o=0;o<t.length;++o){const t=r[o];if(o>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&o<e.length){i=n.FLOAT_NULL;break}}l[s]=i}return n.Column.fromFloat32Array("Similarity",l)}},8601:(t,e,s)=>{"use strict";s.d(e,{i0:()=>m});var n=s(4469),i=s(976),r=s(6414),o=s.n(r),a=s(1821),l=s(499);const h={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN 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'${u.name}' alphabet '${p}'.`]};g="RNA"}const f=function(t){const e=t.length,s=new Array(e),n=l.Cn.getOrCreate(t).getSplitter();for(let i=0;i<e;++i){const e=t.get(i);s[i]=e?o()(n(e)).filter((t=>""!==t)).toArray():[]}return s}(u),y=await async function(t,e,s,i){const r=function(t,e,s){const n=new Map;for(const i of t.getMonomerSymbolsByType(e)){const r=t.getMonomer(e,i);if("RNA"===e&&("Branch"===r.monomerType||"DNA"===s&&r.symbol===h.DEOXYRIBOSE||"RNA"===s&&r.symbol===h.RIBOSE||r.symbol===h.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==r.monomerType){const t={};c.rx.forEach((e=>{t[e]=r[e]})),n.set(r.symbol,t)}}return n}(e,s,i),o=new Map,a=await n.functions.call("Chem:getRdKitModule"),l={value:null};if("RNA"===s){const t="RNA"===i?[h.RIBOSE,h.PHOSPHATE]:[h.DEOXYRIBOSE,h.PHOSPHATE];for(const e of t)d(o,e,r,a,s,l)}for(let e=0;e<t.length;++e){const n=t[e];for(const t of n)if(""!==t)try{d(o,t,r,a,s,l)}catch(e){const s=e instanceof Error?e.message:e.toString(),n=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n${s}\n${n}`),new Error(`Can't get monomer '${t}' from library: ${s}`)}}return o}(f,r,g,p),b=u.length,{molfileList:w,molfileWarningList:C}=await async function(t,e,n,i,r){const o=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(o).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=r/o;let h=[],c=[];const u=new Array(o);for(let s=0;s<o;s++){const h=Math.floor(s*l),c=s===o-1?r:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:n,polymerType:i,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(f,y,p,g,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const v=`molfile(${u.name})`,S=t.columns.getUnusedName(v),T=i.Column.fromStrings(S,w);return T.semType=i.SEMTYPE.MOLECULE,T.setTag(i.TAGS.UNITS,i.UNITS.Molecule.MOLBLOCK),{col:T,warnings:C}}function d(t,e,s,n,i,r){if(!t.has(e)){const o=function(t,e,s,n,i){if(e.has(t)){const r=e.get(t),o=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(r.rgroups),a=function(t){const e=new Map;let s=t.indexOf(h.V2K_A_LINE,0),n=s;for(;-1!==s;){n=t.indexOf("\n",s);const i=parseInt(t.substring(s,n).replace(/^A\s+/,""));s=t.indexOf("R",n),n=t.indexOf("\n",s);const r=parseInt(t.substring(s,n).replace(/^R/,""));e.set(i,r),s=t.indexOf(h.V2K_A_LINE,n)}for(s=t.indexOf(h.V2K_RGP_LINE,0),n=t.indexOf("\n",s);-1!==s;){s+=h.V2K_RGP_SHIFT,n=t.indexOf("\n",s);const i=t.substring(s,n).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<i.length;t+=2){if(e.has(i[t])&&e.get(i[t])!==i[t+1])throw new Error(`r-group index ${i[t]} has already been added with a different value`);e.set(i[t],i[t+1])}s=t.indexOf(h.V2K_RGP_LINE,n)}return e}(r.molfile),l=function(t,e){const s=e.get_mol(t),n=s.get_v3Kmolblock();return s.delete(),n}(function(t){let e=t.indexOf(h.V2K_A_LINE,0);-1===e&&(e=t.indexOf(h.V2K_RGP_LINE));const s=t.indexOf(h.V3K_END,e);return t.substring(0,e)+t.substring(s)}(r.molfile),s),c=function(t){let e=(t=t.replaceAll("\r","")).indexOf(h.V3K_BEGIN_COUNTS_LINE)+h.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const n=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:n,bondCount:parseInt(t.substring(e,s))}}(l),m=function(t,e){const s=new Array(e),n=new Float32Array(e),i=new Float32Array(e),r=new Array(e);let o=t.indexOf(h.V3K_BEGIN_ATOM_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;l++){o=t.indexOf(h.V3K_BEGIN_DATA_LINE,o)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o),o=a+1,a=t.indexOf(" ",o),s[l]=t.substring(o,a);const e=new Array(2);for(let s=0;s<2;++s)o=a+1,a=t.indexOf(" ",o),e[s]=parseFloat(t.substring(o,a));n[l]=e[0],i[l]=e[1],o=a,a=t.indexOf("\n",o)+1,r[l]=t.slice(o,a),o=a}return{atomTypes:s,x:n,y:i,kwargs:r}}(l,c.atomCount),d=function(t,e){const s=new Uint32Array(e),n=new Array(e),i=new Map,r=new Map;let o=t.indexOf(h.V3K_BEGIN_BOND_BLOCK);o=t.indexOf("\n",o);let a=o;for(let l=0;l<e;++l){const e=new Array(3);o=t.indexOf(h.V3K_BEGIN_DATA_LINE,a)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",o);for(let s=0;s<3;++s)o=a+1,a=Math.min(t.indexOf("\n",o),t.indexOf(" ",o)),e[s]=parseInt(t.slice(o,a));s[l]=e[0],n[l]=e.slice(1);const c=t.indexOf("\n",o);let u=t.slice(a,c),m=u.indexOf(h.V3K_BOND_CONFIG);if(-1!==m){m=u.indexOf("=",m)+1;let t=u.indexOf(" ",m);-1===t&&(t=u.length);const e=parseInt(u.slice(m,t));i.set(l,e);const s=h.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||r.set(l,u)}return{bondTypes:s,atomPairs:n,bondConfiguration:i,kwargs:r}}(l,c.bondCount),y={atoms:m,bonds:d,meta:p(m,d,o,a)};return"PEPTIDE"===n?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;T(t,-n[e],-i[e]);const r=C(n[s],i[s]);v(t.atoms,-r),n[t.meta.rNodes[1]-1]<0&&function(t){S(t,!1)}(t);const o=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const n=s[t],i=s[(t+1)%2];e.has(n)?e.get(n)?.push(i):e.set(n,new Array(1).fill(i))}return e}(t);let s=0,n=0;for(;0===s;){const i=e.get(t.meta.terminalNodes[1])[n];t.atoms.atomTypes[i-1]===h.OXYGEN&&i!==t.meta.rNodes[1]&&(s=i),n++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){S(t,!0)}(t),v(t.atoms,-function(t,e){return C(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,o),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const n=e-1,i=s-1,r=t.atoms.x,o=t.atoms.y,a=r[n],l=o[n];r[n]=r[i],o[n]=o[i],r[i]=a,o[i]=l}(t,e,t.meta.rNodes[1])}(t,o)}(y):t===h.RIBOSE||t===h.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,n=t.atoms.y;let i=t.meta.terminalNodes[0]-1;const r=t.meta.rNodes[1]-1;T(t,-s[i],-n[i]);const o=C(s[r],n[r]);v(t.atoms,3*Math.PI/2-o),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,n=t.meta.rNodes[2]-1,i=t.meta.terminalNodes[2]-1,r=e[n]-e[i],o=s[n]-s[i];return Math.atan(o/r)+Math.PI/2}(t),i=t.meta.terminalNodes[0]-1,T(t,-s[i],-n[i])}(y,i):t===h.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,n=t.atoms.x,i=t.atoms.y;T(t,-n[e],-i[e]);const r=C(n[s],i[s]);v(t.atoms,Math.PI/2-r)}(y):function(t,e){const s=t.atoms.x,n=t.atoms.y,i=t.meta.terminalNodes[0]-1,r=t.meta.rNodes[0]-1;T(t,-s[i],-n[i]);const o=C(s[r],n[r]),a=e.value;if(!a)throw new Error("The value of sugarBranchToOYAngle is null");v(t.atoms,Math.PI-o+a);const l=function(t,e){return u(Math.sqrt((t.x-e.x)**2+(t.y-e.y)**2))}({x:s[t.meta.rNodes[0]-1],y:n[t.meta.rNodes[0]-1]},{x:s[t.meta.terminalNodes[0]-1],y:n[t.meta.terminalNodes[0]-1]});if(1!=l)for(let t=0;t<s.length;++t)s[t]=u(s[t]/l),n[t]=u(n[t]/l)}(y,i),function(t,e,s){"PEPTIDE"===t?(f(e,t),b(e,e.meta.rNodes[1])):s===h.RIBOSE||s===h.DEOXYRIBOSE?(b(e,e.meta.rNodes[1]),e.meta.rNodes[1]=e.meta.terminalNodes[1],g(e.bonds,e.meta),f(e,t),b(e,e.meta.rNodes[1]),b(e,e.meta.rNodes[0]),b(e,e.meta.rNodes[2])):s===h.PHOSPHATE&&(e.meta.terminalNodes[0]=e.meta.rNodes[0],T(e,-e.atoms.x[e.meta.terminalNodes[0]-1],-e.atoms.y[e.meta.terminalNodes[0]-1]),f(e,t),b(e,e.meta.rNodes[1]))}(n,y,t),function(t){let e=0;for(;e<t.atoms.atomTypes.length;)t.atoms.atomTypes[e]===h.HYDROGEN&&(b(t,e+1),--e),++e}(y),y}return null}(e,s,n,i,r);if(!o)throw new Error(`Monomer with symbol '${e}' is absent the monomer library`);t.set(e,o)}}function p(t,e,s,n){const 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";return n?i.substring(0,e-1)+"…":i}function M(t,e,s="-"){const n=e.map((e=>{const n=function(t,e,s="-"){const n=new Set([...new Set(Object.keys(t)),...e]);n.delete(s);const i=[],r=[];for(const s of n)i.push(s in t?t[s]:0),r.push(e.has(s)?1:0);const o=new h.OW(i),a=new h.OW(r);return(0,c.MA)(o,a)/((0,c.$G)(o)*(0,c.$G)(a))}(t,e.alphabet,s);return new o.d(e,t,n)}));let i;const r=Math.max(...n.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return i=r>0?n.find((t=>t.similarity===r)).name:"UN",i}function A(t,e=5){let s;if(t.semType==n.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const n=function(t,e,s){return t.categories,function(t,e){const s={};let n=!0,i=null;for(const r of t)if(null==i?i=r.length:r.length!==i&&(n=!1),r.length>=e)for(const t of r)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:n}}(r()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,p);s=M(n.freq,a.XS)}return E(s)}function E(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(n.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var n=s(976),i=s(6414),r=s.n(i),o=s(585);function a(t){const e=(0,o.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return i.push(e),e},i=[],a=t.length,l=n.DataFrame.create(a);for(let n=0;n<a;++n){const o=t.get(n);if(null==o)continue;const a=e(o);for(const[t,e]of r().enumerate(a))((i[e]??null)||s(e)).set(n,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>m});var n=s(976),i=s(6414),r=s.n(i),o=s(8447),a=s(585),l=s(489),h=s(7228);const c=new class{constructor(){this.uhTemp=`units-handler.${n.SEMTYPE.MACROMOLECULE}`}},u={[o.r2.FASTA]:"-",[o.r2.SEPARATOR]:"",[o.r2.HELM]:"*"};class m{static setUnitsToFastaColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.FASTA)throw new Error(`The column of notation '${o.r2.FASTA}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(n.TAGS.UNITS,o.r2.FASTA),m.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE||t.column.getTag(n.TAGS.UNITS)!==o.r2.SEPARATOR)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must be '${n.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${o.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(n.TAGS.UNITS,o.r2.SEPARATOR),t.column.setTag("separator",e),m.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==n.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${o.r2.HELM}' must be '${n.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(n.TAGS.UNITS,o.r2.HELM),m.setTags(t)}static setTags(t){const e=t.column.getTag(n.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[o.r2.FASTA,o.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");let e=t.column.getTag("aligned");null===e&&(e=s.sameLength?"SEQ.MSA":"SEQ",t.column.setTag("aligned",e));let n=t.column.getTag("alphabet");if(null===n&&(n=(0,a.w4)(s.freq,o.XS),t.column.setTag("alphabet",n)),"UN"===n){const e=Object.keys(s.freq).length,n=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",n?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===o.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==o.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===o.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),n=this._column.categories;for(let i=0;i<e;i++){const e=n[s[i]];this._splitted[i]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const n of this.splitted){null==s?s=n.length:n.length!==s&&(e=!1);for(const e of n)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=Math.max(...this.splitted.map((t=>t.length)))),this._maxLength}get posList(){if(null===this._posList){const t=this.column.getTag(".positionNames");this._posList=t?t.split(o.CI).map((t=>t.trim())):r().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===o.r2.FASTA}isSeparator(){return this.notation===o.r2.SEPARATOR}isHelm(){return this.notation===o.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===o.r2.FASTA&&t===u[o.r2.FASTA]||this.units===o.r2.HELM&&t===u[o.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return o.r2.FASTA;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return o.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(o.r2.HELM))return o.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()?"DNA1{":this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"D(":this.isRna()?"R(":"",this.isDna()||this.isRna()?")P":"","}$$$$"]}getNewColumn(t,e){const s=this.column,i=s.length,r=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(r),l=n.Column.fromList("string",a,new Array(i).fill(""));if(l.semType=n.SEMTYPE.MACROMOLECULE,l.setTag(n.TAGS.UNITS,t),t===o.r2.SEPARATOR){if(!e)throw new Error(`Notation '${o.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(n.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==o.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=m.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[o.r2.FASTA,o.r2.SEPARATOR,o.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!m.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const i=n.Column.fromList("string",e,new Array(t).fill(""));return i.semType=n.SEMTYPE.MACROMOLECULE,i.setTag(n.TAGS.UNITS,s),i}getSplitter(t){if(this.units.toLowerCase().startsWith(o.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?a.kB:a.FJ;if(this.units.toLowerCase().startsWith(o.r2.SEPARATOR))return(0,a.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(o.r2.HELM))return a.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");if(this.isMsa())return l.U.HAMMING;switch(this.alphabet){case"DNA":case"RNA":default:return l.U.LEVENSHTEIN;case"PT":return l.U.NEEDLEMANN_WUNSCH}}getDistanceFunction(){return l.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,h.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,a.Ar)(this.separator);for(const t of this.column.categories){const n=s(t);for(const t of n)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===o.r2.FASTA}toSeparator(t){return t===o.r2.SEPARATOR}toHelm(t){return t===o.r2.HELM}convertHelmToFastaSeparator(t,e,s,n){n||(n=this.toFasta(e)?u[o.r2.FASTA]:u[o.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const i=/(R\(|D\(|\)|P)/g,r=t.startsWith("DNA")||t.startsWith("RNA"),a=this.splitter(t),l=[];for(let t=0;t<a.length;t++){let s=a[t];if(r&&(s=s.replace(i,"")),s===u[o.r2.HELM])l.push(n);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";l.push(t)}else l.push(s)}return l.join(s)}convert(t,e){const s=this.getConverter(t,e),n=this.getNewColumn(t,e);return n.init((t=>s(this.column.get(t)))),n}getRegion(t,e,s){const n=this.getNewColumn(this.notation,this.separator);n.name=s,Math.max(...this.splitted.map((t=>t.length)));const i=t??0,r=e??this.maxLength-1,a=this.getJoiner(),l=r-i+1;n.init((t=>{const e=this.splitted[t],s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:u[this.notation]}return a(s)}));const h=t=>{const e=t.split(",").map((t=>t.trim())),s=new Array(l);for(let t=0;t<l;++t){const n=i+t;s[t]=n<e.length?e[n]:"?"}return s.join(o.CI)},c=this.column.getTag(".positionNames");c&&n.setTag(".positionNames",h(c));const m=this.column.getTag(".positionLabels");return m&&n.setTag(".positionLabels",h(m)),n}getJoiner(){const t=this;if(this.notation===o.r2.FASTA)return function(e){return p(t,e)};if(this.notation===o.r2.SEPARATOR)return function(e){return g(t,e,t.separator)};if(this.notation===o.r2.HELM){const e="DNA"===t.alphabet||"RNA"===t.alphabet;return function(s){return f(t,s,e)}}throw new Error}getConverter(t,e=undefined){if(t===o.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${o.r2.SEPARATOR}'.`);const s=this;if(t===o.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?y(t,e):t.getSplitter()(e);return p(t,s)}(s,t)};if(t===o.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA")||e.startsWith("RNA"),n=t.getSplitter()(e);return f(t,n,s)}(s,t)};if(t===o.r2.SEPARATOR)return function(t){return function(t,e,s){const n=t.isHelm()?y(t,e):t.getSplitter()(e);return g(t,n,s)}(s,t,e)};throw new Error}constructor(t){if(this._splitter=null,this._splitted=null,this._stats=null,this._maxLength=null,this._posList=null,t.type!=n.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${n.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(n.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?u[o.r2.FASTA]:this.isHelm()?u[o.r2.HELM]:u[o.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())m.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");m.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(n.TAGS.UNITS)}'.`);m.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return c.uhTemp in t.temp||(t.temp[c.uhTemp]=new m(t)),t.temp[c.uhTemp]}}const d=/[RD]\((\w)\)P?/g;function p(t,e){const s=new Array(e.length);for(const[n,i]of r().enumerate(e)){let r=n;t.isHelm()&&(r=n.replace(d,"$1")),t.isGap(r)?r=u[o.r2.FASTA]:r.length>1&&(r="["+e[i]+"]"),s[i]=r}return s.join("")}function g(t,e,s){const n=new Array(e.length);for(const[s,i]of r().enumerate(e)){let e=s;t.isGap(e)&&(e=u[o.r2.SEPARATOR]),n[i]=e}return n.map((t=>t??"")).join(s)}function f(t,e,s){const[n,i,a,l]=t.getHelmWrappers();return`${n}${r()(e).map((e=>{let n=e;return n=t.isGap(n)?u[o.r2.HELM]:s?n.replace(d,"$1"):1==e.length?`${i}${e}${a}`:`${i}[${e}]${a}`,n})).toArray().join(".")}${l}`}function y(t,e){const s=t.getSplitter()(e),n=new Array(s.length),i=e.startsWith("DNA"),o=e.startsWith("RNA");for(const[t,e]of r().enumerate(s)){let s=t;(i||o)&&(s=s.replace(d,"$1"),s="P"===s?null:s),n[e]=s}return n.filter((t=>null!==t))}},9298:(t,e,s)=>{"use strict";var n,i,r,o,a,l;s.d(e,{Ct:()=>l,DX:()=>n,ES:()=>i,dE:()=>a,iD:()=>o,vS:()=>h,vw:()=>r}),function(t){t.tooltipWebLogo=".tooltipWebLogo"}(n||(n={})),function(t){t.Entropy="Entropy",t.full="100%"}(i||(i={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(r||(r={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(o||(o={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=i.Entropy,this.positionWidth=16,this.verticalAlignment=r.MIDDLE,this.horizontalAlignment=o.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>n});class n{constructor(t=!0,e=!0){const n=navigator.hardwareConcurrency;this._workerCount=t?Math.max(n-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(18),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0){return new Promise((async(n,i)=>{try{const i=t.length,r=new Array(this._workerCount),o=i*(i-1)/2;this._workerCount=Math.min(this._workerCount,o);const a=o/this._workerCount,l=new 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s}minRow(t){if(b(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){b(this,t),A(this);let e=this.get(t,0),s=[t,0];for(let n=1;n<this.columns;n++)this.get(t,n)<e&&(e=this.get(t,n),s[1]=n);return s}maxColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){w(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)>e&&(e=this.get(n,t),s[0]=n);return s}minColumn(t){if(w(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){w(this,t),A(this);let e=this.get(0,t),s=[0,t];for(let n=1;n<this.rows;n++)this.get(n,t)<e&&(e=this.get(n,t),s[0]=n);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){E.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let n=0;n<e.length;n++)s+=e[n]*t[n];return s}mmul(t){t=I.checkMatrix(t);let e=this.rows,s=this.columns,n=t.columns,i=new I(e,n),r=new Float64Array(s);for(let o=0;o<n;o++){for(let e=0;e<s;e++)r[e]=t.get(e,o);for(let t=0;t<e;t++){let e=0;for(let n=0;n<s;n++)e+=this.get(t,n)*r[n];i.set(t,o,e)}}return i}strassen2x2(t){t=I.checkMatrix(t);let e=new I(2,2);const s=this.get(0,0),n=t.get(0,0),i=this.get(0,1),r=t.get(0,1),o=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(n+h),u=(o+l)*n,m=s*(r-h),d=l*(a-n),p=(s+i)*h,g=c+d-p+(i-l)*(a+h),f=m+p,y=u+d,b=c-u+m+(o-s)*(n+r);return e.set(0,0,g),e.set(0,1,f),e.set(1,0,y),e.set(1,1,b),e}strassen3x3(t){t=I.checkMatrix(t);let e=new I(3,3);const s=this.get(0,0),n=this.get(0,1),i=this.get(0,2),r=this.get(1,0),o=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),u=t.get(0,0),m=t.get(0,1),d=t.get(0,2),p=t.get(1,0),g=t.get(1,1),f=t.get(1,2),y=t.get(2,0),b=t.get(2,1),w=t.get(2,2),C=(s-r)*(-m+g),v=(-s+r+o)*(u-m+g),S=(r+o)*(-u+m),T=s*u,M=(-s+l+h)*(u-d+f),A=(-s+l)*(d-f),E=(l+h)*(-u+d),x=(-i+h+c)*(g+y-b),N=(i-c)*(g-b),L=i*y,_=(h+c)*(-y+b),R=(-i+o+a)*(f+y-w),O=(i-a)*(f-w),P=(o+a)*(-y+w),k=T+L+n*p,G=(s+n+i-r-o-h-c)*g+v+S+T+x+L+_,F=T+M+E+(s+n+i-o-a-l-h)*f+L+R+P,W=C+o*(-u+m+p-g-f-y+w)+v+T+L+R+O,V=C+v+S+T+a*b,H=L+R+O+P+r*d,D=T+M+A+h*(-u+d+p-g-f-y+b)+x+N+L,B=x+N+L+_+l*m,U=T+M+A+E+c*w;return e.set(0,0,k),e.set(0,1,G),e.set(0,2,F),e.set(1,0,W),e.set(1,1,V),e.set(1,2,H),e.set(2,0,D),e.set(2,1,B),e.set(2,2,U),e}mmulStrassen(t){t=I.checkMatrix(t);let e=this.clone(),s=e.rows,n=e.columns,i=t.rows,r=t.columns;function o(t,e,s){let n=t.rows,i=t.columns;if(n===e&&i===s)return t;{let n=E.zeros(e,s);return n=n.setSubMatrix(t,0,0),n}}n!==i&&console.warn(`Multiplying ${s} x ${n} and ${i} x ${r} matrix: dimensions do not match.`);let a=Math.max(s,i),l=Math.max(n,r);return e=o(e,a,l),function t(e,s,n,i){if(n<=512||i<=512)return e.mmul(s);n%2==1&&i%2==1?(e=o(e,n+1,i+1),s=o(s,n+1,i+1)):n%2==1?(e=o(e,n+1,i),s=o(s,n+1,i)):i%2==1&&(e=o(e,n,i+1),s=o(s,n,i+1));let r=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,r-1,0,a-1),h=s.subMatrix(0,r-1,0,a-1),c=e.subMatrix(0,r-1,a,e.columns-1),u=s.subMatrix(0,r-1,a,s.columns-1),m=e.subMatrix(r,e.rows-1,0,a-1),d=s.subMatrix(r,s.rows-1,0,a-1),p=e.subMatrix(r,e.rows-1,a,e.columns-1),g=s.subMatrix(r,s.rows-1,a,s.columns-1),f=t(E.add(l,p),E.add(h,g),r,a),y=t(E.add(m,p),h,r,a),b=t(l,E.sub(u,g),r,a),w=t(p,E.sub(d,h),r,a),C=t(E.add(l,c),g,r,a),v=t(E.sub(m,l),E.add(h,u),r,a),S=t(E.sub(c,p),E.add(d,g),r,a),T=E.add(f,w);T.sub(C),T.add(S);let M=E.add(b,C),A=E.add(y,w),x=E.sub(f,y);x.add(b),x.add(v);let I=E.zeros(2*T.rows,2*T.columns);return I=I.setSubMatrix(T,0,0),I=I.setSubMatrix(M,T.rows,0),I=I.setSubMatrix(A,0,T.columns),I=I.setSubMatrix(x,T.rows,T.columns),I.subMatrix(0,n-1,0,i-1)}(e,t=o(t,a,l),a,l)}scaleRows(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new I(this.rows,this.columns);for(let t=0;t<this.rows;t++){const i=this.getRow(t);i.length>0&&m(i,{min:e,max:s,output:i}),n.setRow(t,i)}return n}scaleColumns(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{min:e=0,max:s=1}=t;if(!Number.isFinite(e))throw new TypeError("min must be a number");if(!Number.isFinite(s))throw new TypeError("max must be a number");if(e>=s)throw new RangeError("min must be smaller than max");let n=new I(this.rows,this.columns);for(let t=0;t<this.columns;t++){const i=this.getColumn(t);i.length&&m(i,{min:e,max:s,output:i}),n.setColumn(t,i)}return n}flipRows(){const t=Math.ceil(this.columns/2);for(let e=0;e<this.rows;e++)for(let s=0;s<t;s++){let t=this.get(e,s),n=this.get(e,this.columns-1-s);this.set(e,s,n),this.set(e,this.columns-1-s,t)}return this}flipColumns(){const t=Math.ceil(this.rows/2);for(let e=0;e<this.columns;e++)for(let s=0;s<t;s++){let t=this.get(s,e),n=this.get(this.rows-1-s,e);this.set(s,e,n),this.set(this.rows-1-s,e,t)}return this}kroneckerProduct(t){t=I.checkMatrix(t);let e=this.rows,s=this.columns,n=t.rows,i=t.columns,r=new I(e*n,s*i);for(let o=0;o<e;o++)for(let e=0;e<s;e++)for(let s=0;s<n;s++)for(let a=0;a<i;a++)r.set(n*o+s,i*e+a,this.get(o,e)*t.get(s,a));return r}kroneckerSum(t){if(t=I.checkMatrix(t),!this.isSquare()||!t.isSquare())throw new Error("Kronecker Sum needs two Square Matrices");let e=this.rows,s=t.rows,n=this.kroneckerProduct(I.eye(s,s)),i=I.eye(e,e).kroneckerProduct(t);return n.add(i)}transpose(){let t=new I(this.columns,this.rows);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(s,e,this.get(e,s));return t}sortRows(t=x){for(let e=0;e<this.rows;e++)this.setRow(e,this.getRow(e).sort(t));return this}sortColumns(t=x){for(let e=0;e<this.columns;e++)this.setColumn(e,this.getColumn(e).sort(t));return this}subMatrix(t,e,s,n){S(this,t,e,s,n);let i=new I(e-t+1,n-s+1);for(let r=t;r<=e;r++)for(let e=s;e<=n;e++)i.set(r-t,e-s,this.get(r,e));return i}subMatrixRow(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.columns-1),e>s||e<0||e>=this.columns||s<0||s>=this.columns)throw new RangeError("Argument out of range");let n=new I(t.length,s-e+1);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.rows)throw new RangeError(`Row index out of range: ${t[i]}`);n.set(i,r-e,this.get(t[i],r))}return n}subMatrixColumn(t,e,s){if(void 0===e&&(e=0),void 0===s&&(s=this.rows-1),e>s||e<0||e>=this.rows||s<0||s>=this.rows)throw new RangeError("Argument out of range");let n=new I(s-e+1,t.length);for(let i=0;i<t.length;i++)for(let r=e;r<=s;r++){if(t[i]<0||t[i]>=this.columns)throw new RangeError(`Column index out of range: ${t[i]}`);n.set(r-e,i,this.get(r,t[i]))}return n}setSubMatrix(t,e,s){if((t=I.checkMatrix(t)).isEmpty())return this;S(this,e,e+t.rows-1,s,s+t.columns-1);for(let n=0;n<t.rows;n++)for(let i=0;i<t.columns;i++)this.set(e+n,s+i,t.get(n,i));return this}selection(t,e){!function(t,e){if(!a(e))throw new TypeError("row indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.rows)throw new RangeError("row indices are out of range")}(this,t),function(t,e){if(!a(e))throw new TypeError("column indices must be an array");for(let s=0;s<e.length;s++)if(e[s]<0||e[s]>=t.columns)throw new RangeError("column indices are out of range")}(this,e);let s=new I(t.length,e.length);for(let n=0;n<t.length;n++){let i=t[n];for(let t=0;t<e.length;t++){let r=e[t];s.set(n,t,this.get(i,r))}}return s}trace(){let t=Math.min(this.rows,this.columns),e=0;for(let s=0;s<t;s++)e+=this.get(s,s);return e}clone(){let t=new I(this.rows,this.columns);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.set(e,s,this.get(e,s));return t}sum(t){switch(t){case"row":return function(t){let e=T(t.rows);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]+=t.get(s,n);return e}(this);case"column":return function(t){let e=T(t.columns);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]+=t.get(s,n);return e}(this);case void 0:return function(t){let e=0;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e+=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}product(t){switch(t){case"row":return function(t){let e=T(t.rows,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[s]*=t.get(s,n);return e}(this);case"column":return function(t){let e=T(t.columns,1);for(let s=0;s<t.rows;++s)for(let n=0;n<t.columns;++n)e[n]*=t.get(s,n);return e}(this);case void 0:return function(t){let e=1;for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)e*=t.get(s,n);return e}(this);default:throw new Error(`invalid option: ${t}`)}}mean(t){const e=this.sum(t);switch(t){case"row":for(let t=0;t<this.rows;t++)e[t]/=this.columns;return e;case"column":for(let t=0;t<this.columns;t++)e[t]/=this.rows;return e;case void 0:return e/this.size;default:throw new Error(`invalid option: ${t}`)}}variance(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{unbiased:s=!0,mean:n=this.mean(t)}=e;if("boolean"!=typeof s)throw new TypeError("unbiased must be a boolean");switch(t){case"row":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<n;o++){let n=0,a=0,l=0;for(let e=0;e<i;e++)l=t.get(o,e)-s[o],n+=l,a+=l*l;e?r.push((a-n*n/i)/(i-1)):r.push((a-n*n/i)/i)}return r}(this,s,n);case"column":if(!a(n))throw new TypeError("mean must be an array");return function(t,e,s){const n=t.rows,i=t.columns,r=[];for(let o=0;o<i;o++){let i=0,a=0,l=0;for(let e=0;e<n;e++)l=t.get(e,o)-s[o],i+=l,a+=l*l;e?r.push((a-i*i/n)/(n-1)):r.push((a-i*i/n)/n)}return r}(this,s,n);case void 0:if("number"!=typeof n)throw new TypeError("mean must be a number");return function(t,e,s){const n=t.rows,i=t.columns,r=n*i;let o=0,a=0,l=0;for(let e=0;e<n;e++)for(let n=0;n<i;n++)l=t.get(e,n)-s,o+=l,a+=l*l;return e?(a-o*o/r)/(r-1):(a-o*o/r)/r}(this,s,n);default:throw new Error(`invalid option: ${t}`)}}standardDeviation(t,e){"object"==typeof t&&(e=t,t=void 0);const s=this.variance(t,e);if(void 0===t)return Math.sqrt(s);for(let t=0;t<s.length;t++)s[t]=Math.sqrt(s[t]);return s}center(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");const{center:s=this.mean(t)}=e;switch(t){case"row":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[s])}(this,s),this;case"column":if(!a(s))throw new TypeError("center must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e[n])}(this,s),this;case void 0:if("number"!=typeof s)throw new TypeError("center must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)-e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}scale(t,e={}){if("object"==typeof t&&(e=t,t=void 0),"object"!=typeof e)throw new TypeError("options must be an object");let s=e.scale;switch(t){case"row":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.rows;s++){let n=0;for(let e=0;e<t.columns;e++)n+=Math.pow(t.get(s,e),2)/(t.columns-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[s])}(this,s),this;case"column":if(void 0===s)s=function(t){const e=[];for(let s=0;s<t.columns;s++){let n=0;for(let e=0;e<t.rows;e++)n+=Math.pow(t.get(e,s),2)/(t.rows-1);e.push(Math.sqrt(n))}return e}(this);else if(!a(s))throw new TypeError("scale must be an array");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e[n])}(this,s),this;case void 0:if(void 0===s)s=function(t){const e=t.size-1;let s=0;for(let n=0;n<t.columns;n++)for(let i=0;i<t.rows;i++)s+=Math.pow(t.get(i,n),2)/e;return Math.sqrt(s)}(this);else if("number"!=typeof s)throw new TypeError("scale must be a number");return function(t,e){for(let s=0;s<t.rows;s++)for(let n=0;n<t.columns;n++)t.set(s,n,t.get(s,n)/e)}(this,s),this;default:throw new Error(`invalid option: ${t}`)}}toString(t){return g(this,t)}}function x(t,e){return t-e}E.prototype.klass="Matrix","undefined"!=typeof Symbol&&(E.prototype[Symbol.for("nodejs.util.inspect.custom")]=function(){return g(this)}),E.random=E.rand,E.randomInt=E.randInt,E.diagonal=E.diag,E.prototype.diagonal=E.prototype.diag,E.identity=E.eye,E.prototype.negate=E.prototype.neg,E.prototype.tensorProduct=E.prototype.kroneckerProduct;class I extends E{constructor(t,e){if(super(),I.isMatrix(t))return t.clone();if(Number.isInteger(t)&&t>=0){if(this.data=[],!(Number.isInteger(e)&&e>=0))throw new TypeError("nColumns must be a positive integer");for(let s=0;s<t;s++)this.data.push(new Float64Array(e))}else{if(!a(t))throw new TypeError("First argument must be a positive number or an array");{const s=t;if("number"!=typeof(e=(t=s.length)?s[0].length:0))throw new TypeError("Data must be a 2D array with at least one element");this.data=[];for(let n=0;n<t;n++){if(s[n].length!==e)throw new RangeError("Inconsistent array dimensions");if(!s[n].every((t=>"number"==typeof t)))throw new TypeError("Input data contains non-numeric values");this.data.push(Float64Array.from(s[n]))}}}this.rows=t,this.columns=e}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}removeRow(t){return b(this,t),this.data.splice(t,1),this.rows-=1,this}addRow(t,e){return void 0===e&&(e=t,t=this.rows),b(this,t,!0),e=Float64Array.from(C(this,e)),this.data.splice(t,0,e),this.rows+=1,this}removeColumn(t){w(this,t);for(let e=0;e<this.rows;e++){const s=new Float64Array(this.columns-1);for(let n=0;n<t;n++)s[n]=this.data[e][n];for(let n=t+1;n<this.columns;n++)s[n-1]=this.data[e][n];this.data[e]=s}return this.columns-=1,this}addColumn(t,e){void 0===e&&(e=t,t=this.columns),w(this,t,!0),e=v(this,e);for(let s=0;s<this.rows;s++){const n=new Float64Array(this.columns+1);let i=0;for(;i<t;i++)n[i]=this.data[s][i];for(n[i++]=e[s];i<this.columns+1;i++)n[i]=this.data[s][i-1];this.data[s]=n}return this.columns+=1,this}}!function(t,e){t.prototype.add=function(t){return"number"==typeof t?this.addS(t):this.addM(t)},t.prototype.addS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t);return this},t.prototype.addM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t.get(e,s));return this},t.add=function(t,s){return new e(t).add(s)},t.prototype.sub=function(t){return"number"==typeof t?this.subS(t):this.subM(t)},t.prototype.subS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t);return this},t.prototype.subM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t.get(e,s));return this},t.sub=function(t,s){return new e(t).sub(s)},t.prototype.subtract=t.prototype.sub,t.prototype.subtractS=t.prototype.subS,t.prototype.subtractM=t.prototype.subM,t.subtract=t.sub,t.prototype.mul=function(t){return"number"==typeof t?this.mulS(t):this.mulM(t)},t.prototype.mulS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t);return this},t.prototype.mulM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t.get(e,s));return this},t.mul=function(t,s){return new e(t).mul(s)},t.prototype.multiply=t.prototype.mul,t.prototype.multiplyS=t.prototype.mulS,t.prototype.multiplyM=t.prototype.mulM,t.multiply=t.mul,t.prototype.div=function(t){return"number"==typeof t?this.divS(t):this.divM(t)},t.prototype.divS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t);return this},t.prototype.divM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t.get(e,s));return this},t.div=function(t,s){return new e(t).div(s)},t.prototype.divide=t.prototype.div,t.prototype.divideS=t.prototype.divS,t.prototype.divideM=t.prototype.divM,t.divide=t.div,t.prototype.mod=function(t){return"number"==typeof t?this.modS(t):this.modM(t)},t.prototype.modS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t);return this},t.prototype.modM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)%t.get(e,s));return this},t.mod=function(t,s){return new e(t).mod(s)},t.prototype.modulus=t.prototype.mod,t.prototype.modulusS=t.prototype.modS,t.prototype.modulusM=t.prototype.modM,t.modulus=t.mod,t.prototype.and=function(t){return"number"==typeof t?this.andS(t):this.andM(t)},t.prototype.andS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t);return this},t.prototype.andM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)&t.get(e,s));return this},t.and=function(t,s){return new e(t).and(s)},t.prototype.or=function(t){return"number"==typeof t?this.orS(t):this.orM(t)},t.prototype.orS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t);return this},t.prototype.orM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)|t.get(e,s));return this},t.or=function(t,s){return new e(t).or(s)},t.prototype.xor=function(t){return"number"==typeof t?this.xorS(t):this.xorM(t)},t.prototype.xorS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t);return this},t.prototype.xorM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)^t.get(e,s));return this},t.xor=function(t,s){return new e(t).xor(s)},t.prototype.leftShift=function(t){return"number"==typeof t?this.leftShiftS(t):this.leftShiftM(t)},t.prototype.leftShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t);return this},t.prototype.leftShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)<<t.get(e,s));return this},t.leftShift=function(t,s){return new e(t).leftShift(s)},t.prototype.signPropagatingRightShift=function(t){return"number"==typeof t?this.signPropagatingRightShiftS(t):this.signPropagatingRightShiftM(t)},t.prototype.signPropagatingRightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t);return this},t.prototype.signPropagatingRightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>t.get(e,s));return this},t.signPropagatingRightShift=function(t,s){return new e(t).signPropagatingRightShift(s)},t.prototype.rightShift=function(t){return"number"==typeof t?this.rightShiftS(t):this.rightShiftM(t)},t.prototype.rightShiftS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t);return this},t.prototype.rightShiftM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)>>>t.get(e,s));return this},t.rightShift=function(t,s){return new e(t).rightShift(s)},t.prototype.zeroFillRightShift=t.prototype.rightShift,t.prototype.zeroFillRightShiftS=t.prototype.rightShiftS,t.prototype.zeroFillRightShiftM=t.prototype.rightShiftM,t.zeroFillRightShift=t.rightShift,t.prototype.not=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,~this.get(t,e));return this},t.not=function(t){return new e(t).not()},t.prototype.abs=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.abs(this.get(t,e)));return this},t.abs=function(t){return new e(t).abs()},t.prototype.acos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acos(this.get(t,e)));return this},t.acos=function(t){return new e(t).acos()},t.prototype.acosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.acosh(this.get(t,e)));return this},t.acosh=function(t){return new e(t).acosh()},t.prototype.asin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asin(this.get(t,e)));return this},t.asin=function(t){return new e(t).asin()},t.prototype.asinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.asinh(this.get(t,e)));return this},t.asinh=function(t){return new e(t).asinh()},t.prototype.atan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atan(this.get(t,e)));return this},t.atan=function(t){return new e(t).atan()},t.prototype.atanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.atanh(this.get(t,e)));return this},t.atanh=function(t){return new e(t).atanh()},t.prototype.cbrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cbrt(this.get(t,e)));return this},t.cbrt=function(t){return new e(t).cbrt()},t.prototype.ceil=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.ceil(this.get(t,e)));return this},t.ceil=function(t){return new e(t).ceil()},t.prototype.clz32=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.clz32(this.get(t,e)));return this},t.clz32=function(t){return new e(t).clz32()},t.prototype.cos=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cos(this.get(t,e)));return this},t.cos=function(t){return new e(t).cos()},t.prototype.cosh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.cosh(this.get(t,e)));return this},t.cosh=function(t){return new e(t).cosh()},t.prototype.exp=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.exp(this.get(t,e)));return this},t.exp=function(t){return new e(t).exp()},t.prototype.expm1=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.expm1(this.get(t,e)));return this},t.expm1=function(t){return new e(t).expm1()},t.prototype.floor=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.floor(this.get(t,e)));return this},t.floor=function(t){return new e(t).floor()},t.prototype.fround=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.fround(this.get(t,e)));return this},t.fround=function(t){return new e(t).fround()},t.prototype.log=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log(this.get(t,e)));return this},t.log=function(t){return new e(t).log()},t.prototype.log1p=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log1p(this.get(t,e)));return this},t.log1p=function(t){return new e(t).log1p()},t.prototype.log10=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log10(this.get(t,e)));return this},t.log10=function(t){return new e(t).log10()},t.prototype.log2=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.log2(this.get(t,e)));return this},t.log2=function(t){return new e(t).log2()},t.prototype.round=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.round(this.get(t,e)));return this},t.round=function(t){return new e(t).round()},t.prototype.sign=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sign(this.get(t,e)));return this},t.sign=function(t){return new e(t).sign()},t.prototype.sin=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sin(this.get(t,e)));return this},t.sin=function(t){return new e(t).sin()},t.prototype.sinh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sinh(this.get(t,e)));return this},t.sinh=function(t){return new e(t).sinh()},t.prototype.sqrt=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.sqrt(this.get(t,e)));return this},t.sqrt=function(t){return new e(t).sqrt()},t.prototype.tan=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tan(this.get(t,e)));return this},t.tan=function(t){return new e(t).tan()},t.prototype.tanh=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.tanh(this.get(t,e)));return this},t.tanh=function(t){return new e(t).tanh()},t.prototype.trunc=function(){for(let t=0;t<this.rows;t++)for(let e=0;e<this.columns;e++)this.set(t,e,Math.trunc(this.get(t,e)));return this},t.trunc=function(t){return new e(t).trunc()},t.pow=function(t,s){return new e(t).pow(s)},t.prototype.pow=function(t){return"number"==typeof t?this.powS(t):this.powM(t)},t.prototype.powS=function(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t));return this},t.prototype.powM=function(t){if(t=e.checkMatrix(t),this.rows!==t.rows||this.columns!==t.columns)throw new RangeError("Matrices dimensions must be equal");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,Math.pow(this.get(e,s),t.get(e,s)));return this}}(E,I);class N extends E{constructor(t){super(),this.data=t,this.rows=t.length,this.columns=t[0].length}set(t,e,s){return this.data[t][e]=s,this}get(t,e){return this.data[t][e]}}class L{constructor(t){let e,s,n,i,r,o,a,l,h,c=(t=N.checkMatrix(t)).clone(),u=c.rows,m=c.columns,d=new Float64Array(u),p=1;for(e=0;e<u;e++)d[e]=e;for(l=new Float64Array(u),s=0;s<m;s++){for(e=0;e<u;e++)l[e]=c.get(e,s);for(e=0;e<u;e++){for(h=Math.min(e,s),r=0,n=0;n<h;n++)r+=c.get(e,n)*l[n];l[e]-=r,c.set(e,s,l[e])}for(i=s,e=s+1;e<u;e++)Math.abs(l[e])>Math.abs(l[i])&&(i=e);if(i!==s){for(n=0;n<m;n++)o=c.get(i,n),c.set(i,n,c.get(s,n)),c.set(s,n,o);a=d[i],d[i]=d[s],d[s]=a,p=-p}if(s<u&&0!==c.get(s,s))for(e=s+1;e<u;e++)c.set(e,s,c.get(e,s)/c.get(s,s))}this.LU=c,this.pivotVector=d,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=I.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,i,r=t.columns,o=t.subMatrixRow(this.pivotVector,0,r-1),a=e.columns;for(i=0;i<a;i++)for(s=i+1;s<a;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i));for(i=a-1;i>=0;i--){for(n=0;n<r;n++)o.set(i,n,o.get(i,n)/e.get(i,i));for(s=0;s<i;s++)for(n=0;n<r;n++)o.set(s,n,o.get(s,n)-o.get(i,n)*e.get(s,i))}return o}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let n=0;n<s;n++)e*=t.get(n,n);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new I(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new I(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}function _(t,e){let s=0;return Math.abs(t)>Math.abs(e)?(s=e/t,Math.abs(t)*Math.sqrt(1+s*s)):0!==e?(s=t/e,Math.abs(e)*Math.sqrt(1+s*s)):0}class R{constructor(t){let e,s,n,i,r=(t=N.checkMatrix(t)).clone(),o=t.rows,a=t.columns,l=new Float64Array(a);for(n=0;n<a;n++){let t=0;for(e=n;e<o;e++)t=_(t,r.get(e,n));if(0!==t){for(r.get(n,n)<0&&(t=-t),e=n;e<o;e++)r.set(e,n,r.get(e,n)/t);for(r.set(n,n,r.get(n,n)+1),s=n+1;s<a;s++){for(i=0,e=n;e<o;e++)i+=r.get(e,n)*r.get(e,s);for(i=-i/r.get(n,n),e=n;e<o;e++)r.set(e,s,r.get(e,s)+i*r.get(e,n))}}l[n]=-t}this.QR=r,this.Rdiag=l}solve(t){t=I.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,i,r,o,a=t.columns,l=t.clone(),h=e.columns;for(r=0;r<h;r++)for(i=0;i<a;i++){for(o=0,n=r;n<s;n++)o+=e.get(n,r)*l.get(n,i);for(o=-o/e.get(r,r),n=r;n<s;n++)l.set(n,i,l.get(n,i)+o*e.get(n,r))}for(r=h-1;r>=0;r--){for(i=0;i<a;i++)l.set(r,i,l.get(r,i)/this.Rdiag[r]);for(n=0;n<r;n++)for(i=0;i<a;i++)l.set(n,i,l.get(n,i)-l.get(r,i)*e.get(n,r))}return l.subMatrix(0,h-1,0,a-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,i=new I(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?i.set(t,e,s.get(t,e)):t===e?i.set(t,e,this.Rdiag[t]):i.set(t,e,0);return i}get orthogonalMatrix(){let t,e,s,n,i=this.QR,r=i.rows,o=i.columns,a=new I(r,o);for(s=o-1;s>=0;s--){for(t=0;t<r;t++)a.set(t,s,0);for(a.set(s,s,1),e=s;e<o;e++)if(0!==i.get(s,s)){for(n=0,t=s;t<r;t++)n+=i.get(t,s)*a.get(t,e);for(n=-n/i.get(s,s),t=s;t<r;t++)a.set(t,e,a.get(t,e)+n*i.get(t,s))}}return a}}class O{constructor(t,e={}){if((t=N.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,n=t.columns;const{computeLeftSingularVectors:i=!0,computeRightSingularVectors:r=!0,autoTranspose:o=!1}=e;let a,l=Boolean(i),h=Boolean(r),c=!1;if(s<n)if(o){a=t.transpose(),s=a.rows,n=a.columns,c=!0;let e=l;l=h,h=e}else a=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else a=t.clone();let u=Math.min(s,n),m=Math.min(s+1,n),d=new Float64Array(m),p=new I(s,u),g=new I(n,n),f=new Float64Array(n),y=new Float64Array(s),b=new Float64Array(m);for(let t=0;t<m;t++)b[t]=t;let w=Math.min(s-1,n),C=Math.max(0,Math.min(n-2,s)),v=Math.max(w,C);for(let t=0;t<v;t++){if(t<w){d[t]=0;for(let e=t;e<s;e++)d[t]=_(d[t],a.get(e,t));if(0!==d[t]){a.get(t,t)<0&&(d[t]=-d[t]);for(let e=t;e<s;e++)a.set(e,t,a.get(e,t)/d[t]);a.set(t,t,a.get(t,t)+1)}d[t]=-d[t]}for(let e=t+1;e<n;e++){if(t<w&&0!==d[t]){let n=0;for(let i=t;i<s;i++)n+=a.get(i,t)*a.get(i,e);n=-n/a.get(t,t);for(let i=t;i<s;i++)a.set(i,e,a.get(i,e)+n*a.get(i,t))}f[e]=a.get(t,e)}if(l&&t<w)for(let e=t;e<s;e++)p.set(e,t,a.get(e,t));if(t<C){f[t]=0;for(let e=t+1;e<n;e++)f[t]=_(f[t],f[e]);if(0!==f[t]){f[t+1]<0&&(f[t]=0-f[t]);for(let e=t+1;e<n;e++)f[e]/=f[t];f[t+1]+=1}if(f[t]=-f[t],t+1<s&&0!==f[t]){for(let e=t+1;e<s;e++)y[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<n;s++)y[e]+=f[s]*a.get(e,s);for(let e=t+1;e<n;e++){let n=-f[e]/f[t+1];for(let i=t+1;i<s;i++)a.set(i,e,a.get(i,e)+n*y[i])}}if(h)for(let e=t+1;e<n;e++)g.set(e,t,f[e])}}let S=Math.min(n,s+1);if(w<n&&(d[w]=a.get(w,w)),s<S&&(d[S-1]=0),C+1<S&&(f[C]=a.get(C,S-1)),f[S-1]=0,l){for(let t=w;t<u;t++){for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}for(let t=w-1;t>=0;t--)if(0!==d[t]){for(let e=t+1;e<u;e++){let n=0;for(let i=t;i<s;i++)n+=p.get(i,t)*p.get(i,e);n=-n/p.get(t,t);for(let i=t;i<s;i++)p.set(i,e,p.get(i,e)+n*p.get(i,t))}for(let e=t;e<s;e++)p.set(e,t,-p.get(e,t));p.set(t,t,1+p.get(t,t));for(let e=0;e<t-1;e++)p.set(e,t,0)}else{for(let e=0;e<s;e++)p.set(e,t,0);p.set(t,t,1)}}if(h)for(let t=n-1;t>=0;t--){if(t<C&&0!==f[t])for(let e=t+1;e<n;e++){let s=0;for(let i=t+1;i<n;i++)s+=g.get(i,t)*g.get(i,e);s=-s/g.get(t+1,t);for(let i=t+1;i<n;i++)g.set(i,e,g.get(i,e)+s*g.get(i,t))}for(let e=0;e<n;e++)g.set(e,t,0);g.set(t,t,1)}let T=S-1,M=0,A=Number.EPSILON;for(;S>0;){let 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n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(585);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",m=l.GU;var d,p;function g(t,e,s,n,i,r,o=h,a=0,l=!1,d=1,g="",f=!1,y=p.classic,b=[],w=0,C=null,v=[],S=null,T={}){i.textAlign="start";let M=r.substring(0),A=f?"":g;y===p.MSA&&(A="");let E=!0,x=!0,I="difference";null!=C&&null!=C.cell.column&&(E=C.cell.column.temp["color-code"]??!0,x=C.cell.column.temp["compare-with-current"]??!0,I=C.cell.column.temp["highlight-difference"]??"difference");const N=v[w];x&&v.length>0&&"difference"===I&&(d=M==N?.3:d),x&&v.length>0&&"equal"===I&&(d=M!=N?.3:d),null!=S&&(M=m(M,S));const L=M+A;T[L]??(T[L]=i.measureText(L));let _=T[L];T[M]??(T[M]=i.measureText(M));let R=T[M].width;T[A]??(T[A]=i.measureText(A));const O=T[A].width,P=n/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function k(s,n){const r=E?o:u;i.fillStyle=r,i.globalAlpha=d,y===p.classic&&(i.fillText(M,t+s,e+P),i.fillStyle=c,i.fillText(A,t+n,e+P)),y===p.MSA&&i.fillText(M,t+s,e+P)}_=_.width,y===p.MSA&&(R=b[w],_=b[w]);const G=(b[w]??0)-(b[0]??0);if(l||_>s)return k(G,G+R),t+G+R+O;{const e=(s-_)/2;return k(e,e+R),t+G+e+R}}!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(d||(d={})),function(t){t.MSA="MSA",t.classic="classic"}(p||(p={}));var f,y=s(9611),b=s(8447),w=s(7331),C=s(499);!function(t){t.long="long",t.short="short"}(f||(f={}));const v={true:"1",false:"0"};var S=s(3553);const T="rgb(100,100,100)",M=b.GU;function A(t,e,s,n){return t?Math.min(t.canvas.width-s,n):e.canvas.width-s}function E(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],n=e?"":" ";for(const[e,i]of a().enumerate(t)){let r=e;i<t.length&&(r+=`${e?"":"-"}${n}`),s.push(r)}return[s,e]}class x extends r.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const r=t.bounds,o=e.offsetX-t.gridColumn.left+(t.gridColumn.left-r.x),a=s.getPosition(t.tableRowIndex,o),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],r=[i.div(t)];if(s._monomerStructureMap[t])r.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const i={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},o=n.chem.svgMol(e.smiles,void 0,void 0,i);r.push(o),s._monomerStructureMap[t]=o}}i.tooltip.show(i.divV(r),e.x+16,e.y+16)}else i.tooltip.hide()}render(t,e,s,n,i,o,l){let h=0,c=50;const u=o.grid,m=o.cell.column,f=m.temp,w=f["monomer-width"];if("short"===(null!=w?w:"short")){const t=parseInt(m.getTag(d.maxMonomerLength));c=(isNaN(t)?ze.properties?.MaxMonomerLength:t)??4}let S=m.temp["bio-seqCol"];S||(S=new y.A(u,m,(()=>{const t=C.Cn.getOrCreate(m);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:h,monomerToShort:M,monomerLengthLimit:c,monomerLib:Je()}}))),m.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(h=f[".mm.cellRenderer.gapLength"]??h,S.setMonomerLengthLimit(c),S.setSeparatorWidth(S.isMsa()?8:h),m.setTag(".mm.cellRenderer.settingsChanged",v.false));const[E,x]=S.getCellMonomerLengths(o.tableRowIndex);E.length,S.updated&&(f["bio-seqCol"]=S),t.save();try{const l=-1!==o.gridRow?o.grid:null,h=o.cell.value,u=m.getTag("alphabet"),d=50;n=A(l,t,e,n),t.beginPath(),t.rect(e+this.padding,s+this.padding,n-this.padding-1,i-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const y=m.getTag(r.TAGS.UNITS),w=m.getTag("aligned"),v=(0,b.py)(u),M=m.getTag("separator")??"",E=n/5,I=C.Cn.getOrCreate(m).getSplitter(E),N=f["reference-sequence"],L=f["current-word"],_=I(null!=N&&""!=N?N:L??""),R=I(h);let O=T,P=p.classic;w&&w.includes("MSA")&&y==b.r2.SEPARATOR&&(P=p.MSA);for(const[r,l]of a().enumerate(R)){O=v.get(r),t.fillStyle=T;const a=l===R.length-1;if(g(e+this.padding,s,n,i,t,r,O,0,!0,1,M,a,P,x,l,o,_,c,S._monomerLengthMap),d>n)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";ze.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class I extends r.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return S.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,n,i,o,a){const h=o.grid,c=o.cell,u=o.tableColumn,m=c.value??"",d=u.tags.separator,p=u.tags[r.TAGS.UNITS];n=A(h,t,e,n);const[g,f]=m.split("#"),y=(0,l.vU)(p,d);N(t,e,s,n,i,y(g),y(f),p)}}function N(t,e,s,n,i,r,o,l,h,c){if(r.length!==o.length){const t=function(t,e){let s=0,n=0;const i=t.length>e.length?t:e,r=t.length>e.length?e:t;for(let t=0;t<r.length;t++)i[t]===r[t]&&s++;const o=i.length-r.length;for(let t=i.length-1;t>o;t--)i[t]===r[t-o]&&n++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>n?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(r).toArray(),a()(o).toArray());r=t.subParts1,o=t.subParts2}const u=t.measureText(E(r).join("")),m=t.measureText(E(o).join("")),d=Math.max(u.width,m.width);h&&(n=d+4*r.length,t.canvas.width=d+4*r.length);let p=Math.max(e,e+(n-(d+4*r.length))/2)+5;const f=Math.max(s,s+(i-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?d+4*r.length:n,i),t.clip(),t.font="12px monospace",t.textBaseline="top";let y=w.UE.Color;"HELM"!=l&&(y=(0,b.py)(l.substring(l.length-2)));for(let e=0;e<r.length;e++){const s=r[e],a=o[e],l=y.get(s);if(s!=a){const r=y.get(a),o=g(p,f-7,n,i,t,s,l,0,!0),h=g(p,f+7,n,i,t,a,r,0,!0);p=Math.max(h,o),c&&(c[e]=L(s,a,l,r,f,7,i))}else p=g(p,f,n,i,t,s,l,0,!0,.5);p+=4}t.restore()}function L(t,e,s,n,i,r,o){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(E([t]).join("")).width,c=l.measureText(E([e]).join("")).width,u=Math.max(h,c);return a.height=o,a.width=u+4,l.font="12px monospace",l.textBaseline="top",g(0,i-r,u,o,l,t,s,0,!0),g(0,i+r,u,o,l,e,n,0,!0),a}var _,R=s(701),O=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(_||(_={}));const P=new class{constructor(){this.regionTypes=[_.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=O.ES.Entropy}};var k=s(833);const G=_;var F,W;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(F||(F={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight"}(W||(W={}));const V=P;class H extends r.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.filterSourceInput=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(W.skipEmptyPositions,V.skipEmptyPositions,{category:F.DATA}),this.regionTypes=this.stringList(W.regionTypes,V.regionTypes,{category:F.DATA,choices:Object.values(G).filter((t=>t!=G.Unknown))}),this.chains=this.stringList(W.chains,V.chains,{category:F.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(W.fitWidth,V.fitWidth,{category:F.LAYOUT}),this.positionWidth=this.float(W.positionWidth,V.positionWidth,{category:F.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(W.positionHeight,V.positionHeight,{category:F.LAYOUT,choices:Object.keys(O.ES)})}async init(){this.subs.push((0,R.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case W.regionTypes:case W.chains:this.setData(this.dataFrame,this.regions)}switch(t.name){case W.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[k.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case W.fitWidth:case W.positionWidth:this.calcSize();break;case W.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[k.bo.positionWidth]:this.positionWidth});this.calcSize();break;default:this.setData(this.dataFrame,this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,ze.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),ze.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){ze.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&i.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){ze.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),n=[];for(let t=0;t<s.length;t++)for(const i of this.chains){const r=e.find((e=>e.order==s[t]&&e.chain==i));n.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:r.sequenceColumnName,startPositionName:r.positionStartName,endPositionName:r.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,i,e]})())}const r=await Promise.all(n);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of r)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=i.table(this.chains,(t=>[...s.length>0?[i.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",i.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=i.boolInput("",!1,this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.left="10px",this.filterSourceInput.root.style.top="-3px",i.tooltip.bind(this.filterSourceInput.input,"Check to filter sequences for selected VRs"),Math.ceil(255*Math.random()).toString(16),this.host=i.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),ze.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){ze.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,s=13,n=9,i=(this.root.clientWidth-t-(this.logos.length-1)*n-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[k.bo.positionWidth]:i-s.positionMarginValue}),s.root.style.width=i*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[k.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=1==this.filterSourceInput.value?O.Ct.Selected:O.Ct.Filtered;for(let e=0;e<this.logos.length;e++)for(let s=0;s<this.chains.length;s++){const n=this.chains[s];this.logos[e][n].setOptions({[k.bo.filterSource]:t})}}}var D=s(9017),B=s(7656),U=s(7983),Z=s(489);async function Y(t){const e=C.Cn.getOrCreate(t.seqCol);if(e.isFasta()||e.isSeparator()&&e.alphabet&&"UN"!==e.alphabet){let s=Z.U.LEVENSHTEIN,n=t.seqCol.toList();if(e.isSeparator()){const t=e.convert(b.r2.FASTA);n=t.toList(),s=C.Cn.getOrCreate(t).getDistanceFunctionName()}else s=e.getDistanceFunctionName();for(let e=0;e<n.length;e++)n[e]=t.seqCol.isNone(e)?null:n[e];const i=await(0,B.I)(n,t.methodName,s,t.options,!0),o=t.embedAxesNames.map(((t,e)=>r.Column.fromFloat32Array(t,i.embedding[e])));return{distance:i.distance,coordinates:new r.ColumnList(o)}}return await async function(t){return t.seqCol.version!==t.seqCol.temp["last-invalidated-version"]&&await(0,U.HV)(t.seqCol,!1),await n.functions.call("Chem:getChemSpaceEmbeddings",{col:t.seqCol.temp["monomeric-mols"],methodName:t.methodName,similarityMetric:t.similarityMetric,xAxis:t.embedAxesNames[0],yAxis:t.embedAxesNames[1],options:t.options})}(t)}function z(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var q=s(5697),X=s(3379),$=s.n(X),K=s(7795),j=s.n(K),J=s(569),Q=s.n(J),tt=s(3565),et=s.n(tt),st=s(9216),nt=s.n(st),it=s(4589),rt=s.n(it),ot=s(9414),at={};at.styleTagTransform=rt(),at.setAttributes=et(),at.insert=Q().bind(null,"head"),at.domAPI=j(),at.insertStyleElement=nt(),$()(ot.Z,at),ot.Z&&ot.Z.locals&&ot.Z.locals;var lt=s(3914),ht=s(6254);let ct=0;const ut="cliffsDf",mt=new R.Subject,dt="act_diff",pt="sali",gt="sim",ft="line_index",yt=["1_seq","2_seq"],bt="filterCliffs";function wt(t,e,s){const n=e.getBoundingClientRect(),i=t.clientX-n.left,r=t.clientY-n.top;let o=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-i,t.a[1]-r)+Math.hypot(t.b[0]-i,t.b[1]-r)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,o=t)}return o}var Ct=s(1040);async function vt(t,e,s,i,o){e.version!==e.temp["last-invalidated-version"]&&await(0,U.HV)(e,!1);const a=r.DataFrame.create(e.length);return a.columns.addNewString(i).init((t=>e.temp["monomeric-mols"].get(t))),await n.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:i,simArr:o})}function St(t){const e=i.divH([]),s=i.divV([i.divText(t.seqCol.name),i.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,n)=>{const r=i.divText(t.activityCol.get(s).toFixed(2));r.style.display="flex",r.style.justifyContent="left",r.style.paddingLeft="30px",e.append(i.divV([i.divText(t.seqCol.get(s)),r]))})),e}function Tt(t){const e=i.div();e.append(i.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),n=new Array(2);t.line.mols.forEach(((e,i)=>{s[i]=t.seqCol.get(e),n[i]=t.activityCol.get(e)}));const r={},o=C.Cn.getOrCreate(t.seqCol),a=o.getSplitter(),l=At(a(s[0]),a(s[1]),o.units,r);return e.append(i.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(Et(r)),e.append(Mt("Activity delta",Math.abs(n[0]-n[1]))),e.append(Mt("Cliff",t.sali)),e}function Mt(t,e){return i.divH([i.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),i.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function At(t,e,s,n){const i=document.createElement("canvas"),r=i.getContext("2d");return i.height=30,N(r,0,0,0,30,t,e,s,!0,n),i}function Et(t){const e=i.div();if(Object.keys(t).length>0){const s=i.divV([]);s.append(i.divH([i.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),i.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(i.divH([i.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function xt(t,e){const s=r.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(r.TAGS.UNITS,t.col(e[0]).getTag(r.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const n=t.plot.grid();return n.col(e[0]).visible=!1,n.col(e[1]).visible=!1,n}s(7861);var It=s(4004),Nt=s(7228),Lt=s(8601),_t=s(5226);s(9133);class Rt extends r.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[r.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",q.kg[0],{choices:q.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(r.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(r.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>this.render(t)))),this.subs.push(r.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(r.debounce(i.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(r.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===r.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==r.SEMTYPE.MACROMOLECULE&&(n.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Ot=s(7241),Pt=s(4293),kt=s(2669);async function Gt(t){const e=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=C.Cn.getOrCreate(t).getDistanceFunctionName(),n=new kt.m(!0,!1),i=await n.calc(e,s);return n.terminate(),i}function Ft(t){return(e,s)=>{const n=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?n(e,s):n(s,e)}}class Wt extends Rt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new R.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=r.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=r.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const i=s.plot.grid();i.col("indexes").visible=!1;const o=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));i.cell("score",o).cell.value=null,n.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Pt.Y)(this.root,i.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ot.D)(this.moleculeColumn),e=(r.DataFrame.fromColumns([t]),await n.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Gt(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const n=t.toList();if(t.semType!==r.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const i=C.Cn.getOrCreate(t).getDistanceFunctionName(),o=Math.min(Math.max(navigator.hardwareConcurrency-2,1),n.length),a=new Array(o).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(n.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const r=Math.floor(s*n.length/o),u=s===a.length-1?Math.floor((s+1)*n.length/o):n.length;return new Promise(((s,o)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:n,max:i}})=>{t?o(t):(h=Math.min(h,n),c=Math.max(c,i),l.set(e,r),s())},t.postMessage({fnName:i,values:n,templateIdx:e,start:r,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,n=Ft(e),i=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[n(this.targetMoleculeIdx,s)]:1-t[s]})));i.sort(((t,e)=>e.score-t.score));const o=Math.min(this.limit,e),a=i.slice(0,o);this.idxs=r.Column.int("indexes",o).init((t=>a[t].idx)),this.scores=r.Column.float("score",o).init((t=>a[t].score))}createPropertyPanel(t){const e=i.div(),s={},r=this.molCol?.name,o=t.col(r),a=C.Cn.getOrCreate(o),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(r,t.currentRowIdx)),u=At(h,c,a.units,s);e.append(i.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(i.divV([i.divText("Different sequence length:",{style:{fontWeight:"bold"}}),i.divText(`target: ${h.length} monomers`),i.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(Et(s));const m=i.accordion(),d=i.element("i");d.className="grok-icon svg-icon svg-view-layout",m.addTitle(i.span([d,i.label("Similarity search")])),m.addPane("Differences",(()=>e),!0),n.shell.o=m.root}}var Vt=s(8518);class Ht extends Rt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new R.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=r.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=r.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const n=r.DataFrame.fromColumns([s]);n.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[n.currentRowIdx]})),(0,Pt.Y)(this.root,n.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Ot.D)(this.moleculeColumn);r.DataFrame.fromColumns([t]),this.renderMolIds=await n.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Gt(this.moleculeColumn),e=this.moleculeColumn.length,s=Ft(e);this.renderMolIds=(0,Vt.L)(e,Math.min(e,this.limit),((e,n)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(n)?0:t[s(e,n)]))}}var Dt=s(9943),Bt=s(4413),Ut=s(1061),Zt=s(5490),Yt=s(116);const zt={[r.SEMTYPE.MOLECULE]:"Molecules",[r.SEMTYPE.MACROMOLECULE]:"Sequences"};class qt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=i.inputs([]),this.methodsParams={[Yt.AL.UMAP]:new Yt.bD,[Yt.AL.T_SNE]:new Yt.aP},this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=i.columnInput(zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.methodInput=i.choiceInput("Method",Yt.AL.UMAP,[Yt.AL.UMAP,Yt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value])})),this.methodSettingsIcon=i.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):i.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=i.inputs([]);let e=!1;this.similarityMetricInput=i.choiceInput("Similarity",Ct.gk.Tanimoto,q.Rt)}createAlgorithmSettingsDiv(t,e){return i.empty(t),Object.keys(e).forEach((s=>{const n=e[s],r=i.floatInput(n.uiName,n.value,(()=>{n.value=r.value}));i.tooltip.bind(r.root,n.tooltip),t.append(r.root)})),t}onTableInputChanged(t){this.molColInput=i.columnInput(zt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),i.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t)))}}class Xt extends qt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=i.boolInput("Plot Embeddings",!0),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class $t extends qt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=i.intInput("Similarity cutoff",80),i.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=i.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),i.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=i.columnInput("Activities",this.tableInput.value,r.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Kt,jt=s(8457);async function Jt(t,e,s,n){const i=(0,jt.O)(e),o=(0,l.vU)(e.getTag(r.TAGS.UNITS),e.getTag("separator"))(s),a=n===Kt.IDENTITY?function(t,e){const s=e.columns.length,n=new Array(s),i=new Array(s),o=new Array(s);for(let r=0;r<s;++r){const s=e.columns.byIndex(r);n[r]=s.getRawData(),i[r]=s.categories.indexOf(""),o[r]=s.categories.indexOf(t[r]??"")}const a=r.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)n[e][s]===o[e]&&++l[s];l[s]/=t.length}return a}(o,i):n===Kt.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,Nt.Qx)(s,t)}(o,i):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${n}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(Kt||(Kt={}));var Qt,te=function(t,e,s,n){return new(s||(s=Promise))((function(i,r){function o(t){try{l(n.next(t))}catch(t){r(t)}}function a(t){try{l(n.throw(t))}catch(t){r(t)}}function l(t){var e;t.done?i(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(o,a)}l((n=n.apply(t,e||[])).next())}))};class ee{constructor(t,e,s=!1,n){var r;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._stopStartBtn=i.button(i.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=i.button(i.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=i.button(i.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._closeBtn=i.button(i.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(r=null==n?void 0:n.autoStartFirstStep)&&void 0!==r&&r,this._progress.max=0,this._progress.value=1,ee.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=i.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(i.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=i.iconFA("clock");this._isAutomatic||0===e&&(s=i.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const n=i.div(this._steps[e].name,"grok-tutorial-entry-instruction"),r=i.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),o=i.divH([s,n],"grok-tutorial-entry");this._activity.append(o,r)}}_initRoot(){var t,e,s;n.shell.windows.showContextPanel=!0,n.shell.windows.showHelp=!1;const i=Array.from(n.shell.dockManager.rootNode.children)[0];this._node=n.shell.dockManager.dock(this._root,r.DOCK_TYPE.FILL,i,""),(null===(e=null===(t=i.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=i.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return te(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],n=this._activity.getElementsByClassName("grok-icon")[this._currentStep],r=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];n.className="grok-icon far fa-spinner-third fa-spin",r.classList.remove("hidden"),r.classList.add("visible");const o=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,o.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,n,a),yield(0,Ut.gw)(a));const l=i.iconFA("check");if(n.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=i.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return te(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return te(this,void 0,void 0,(function*(){const n=i.div([],"demo-script-countdown");e.classList.add("hidden");let r=s/1e3;const o=this._createSVGIndicator(r);n.append(o),t.prepend(n);const a=setInterval((()=>{r--,0===r&&(clearInterval(a),n.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){n.shell.dockManager.close(this._node),n.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=i.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=i.panel([],"tutorials-main-header"),this._header=i.h2(""),this._headerDiv=i.divH([],"tutorials-root-header"),this._activity=i.panel([],"tutorials-root-description"),this._progressDiv=i.divV([],"tutorials-root-progress"),this._progress=i.element("progress"),this._progressSteps=i.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){n.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ee.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return te(this,void 0,void 0,(function*(){this._initRoot(),n.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function se(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),ze.logger.error(t.message,void 0,s)}ee.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(Qt||(Qt={}));const ne="data/sample_FASTA_PT_activity.csv";var ie=s(1811);async function re(){const t="Dendrogram",e=r.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function oe(){return await n.functions.call("Dendrogram:getDendrogramService",{})}const ae="data/sample_FASTA_PT_activity.csv",le="sequence";var he=s(3336),ce=s.n(he);const ue="data/sample_FASTA_PT_activity.csv";var me=s(8341);const de="samples/HELM.csv";var pe=s(2568),ge=s(525);class fe{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=n.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${ze.name}.${this.funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case k.bo.fixWidth:case k.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ye{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=i.tableInput("Table",n.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.seqColInput=i.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=i.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=i.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE))}}var be=s(9416);class we{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const Ce=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},ve={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class Se{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const r=t.tableColumn.getTag("alphabet"),o=t.cell.value,a="DNA"===r||"RNA"===r?"RNA":"PEPTIDE",l=new we(qe().getBioLib()).getCappedRotatedMonomer(a,o),h=i.div(o),c=l?n.chem.svgMol(l,void 0,void 0,ve):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return i.tooltip.show(i.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){let e=t.temp[Ce.tooltipHandlerTemp];return e||(e=t.temp[Ce.tooltipHandlerTemp]=new Se(t)),e}}class Te extends r.GridCellRenderer{get name(){return S.Of.MONOMER}get cellType(){return S.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,n,i,r,o){if(r.gridRow<0)return;Se.getOrCreate(r.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,b.py)(r.cell.column.getTag("alphabet")),l=r.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,b.GU)(l,6),e+n/2,s+i/2,n)}}class Me extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new R.Subject}}class Ae extends r.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(t){this._properties=t}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(e),this.logger.error(e,void 0,s)}}class Ee extends r.Widget{constructor(t){super(i.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=i.intInput("Max monomer length",ze.properties.MaxMonomerLength,(t=>{ze.properties.MaxMonomerLength=t})),e=i.boolInput("Tooltip WebLogo",ze.properties.TooltipWebLogo,(t=>{ze.properties.TooltipWebLogo=t})),s=i.choiceInput("Default Separator",ze.properties.DefaultSeparator,[".","/","-"],(t=>{ze.properties.DefaultSeparator=t}));this.root.appendChild(i.form([t,e,s]))}}var xe=s(5362),Ie={};Ie.styleTagTransform=rt(),Ie.setAttributes=et(),Ie.insert=Q().bind(null,"head"),Ie.domAPI=j(),Ie.insertStyleElement=nt(),$()(xe.Z,Ie),xe.Z&&xe.Z.locals&&xe.Z.locals;class Ne extends r.Widget{constructor(t){super(i.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=C.Cn.getOrCreate(this.seqCol),e=ze.properties.TooltipWebLogo,s=this.seqCol.getTag(O.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Le="PEPTIDE1{",_e="}$$$$",Re="<All>";function Oe(t){t.setTag("quality",r.SEMTYPE.MACROMOLECULE),t.setTag("aligned","SEQ"),t.setTag("alphabet","PT")}class Pe{constructor(t,e){this.helmColumn=t,this.leftTerminal=e.leftTerminal,this.rightTerminal=e.rightTerminal}transform(){return this.helmColumn.toList().map((t=>this.hasTerminals(t)?this.getTransformedHelm(t):t))}}class ke extends Pe{constructor(t,e){super(t,e)}hasTerminals(t){return!!t.includes(this.rightTerminal+_e)&&(this.leftTerminal===Re||t.includes(Le+this.leftTerminal))}getLinkedPositions(t){return[1,Ve(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return He(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:3})}}class Ge extends Pe{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Re||this.rightTerminal===Re||t.includes(Le+this.leftTerminal)&&t.includes(this.rightTerminal+_e)}getLinkedPositions(t){return[1,Ve(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return He(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:2})}}class Fe extends Pe{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Re||this.rightTerminal===Re||this.getLinkedPositions(t).every((t=>t>0))}getLinkedPositions(t){const e=t.replace(Le,"").replace(_e,"").split("."),s=e.findIndex((t=>t===this.leftTerminal)),n=e.findIndex(((t,e)=>t===this.rightTerminal&&e>s));return[s+1,n+1]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return He(t,{monomerPosition:e[0],attachmentPoint:3},{monomerPosition:e[1],attachmentPoint:3})}}class We{constructor(){}static getInstance(t,e){const s=e.cyclizationType;return"R3-R3"===s?new Fe(t,e):"N-Cys"===s?new ke(t,e):new Ge(t,e)}}function Ve(t){return t.replace(Le,"").replace(_e,"").split(".").length}function He(t,e,s){return t.replace(_e,`}$PEPTIDE1,PEPTIDE1,${e.monomerPosition}:R${e.attachmentPoint}-${s.monomerPosition}:R${s.attachmentPoint}${"$".repeat(6)}`)}async function De(t,e){const s=t.dataFrame,i=C.Cn.getOrCreate(t).convert(b.r2.HELM),o=We.getInstance(i,e).transform(),a=s.columns.getUnusedName(`${e.transformationType}(`+t.name+")"),l=r.Column.fromList("string",a,o);Oe(l),l.setTag("units",b.r2.HELM),l.setTag("cell.renderer","helm"),s.columns.add(l),await n.data.detectSemanticTypes(s)}function Be(t,e,s,n){const i=C.Cn.getOrCreate(t);let r=null,o=null;for(let t=0;t<i.posList.length;++t)i.posList[t]==e&&(r=t),i.posList[t]==s&&(o=t);if(null===r&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===o&&null!==s)throw new Error(`End position ${s} not found.`);if(i.posList.length<o)throw new Error(`End position ${o} exceeds positions length`);const a=n||`${t.name}: (${e??""}-${s??""})`;return i.getRegion(r,o,a)}const Ue={df:r.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(b.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Ze{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??Ue;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(".positionNames",this.data.positionNames),this.data.regions&&e.setTag(".regions",JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await n.data.detectSemanticTypes(this.data.df),this.view=n.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${ze.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,r.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Ye{constructor(t){this.call=t,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const e=t=>this.call.inputParams[t].property.description;this.inputs.table=i.tableInput("Table",this.call.inputParams.table.value??n.shell.tv.dataFrame,void 0,(()=>{}));const s=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(r.SEMTYPE.MACROMOLECULE),o={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.inputs.sequence=i.columnInput("Sequence",n.shell.tv.dataFrame,s,this.sequenceInputChanged.bind(this),o),this.inputs.start=i.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=i.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=i.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=i.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const t in this.call.inputParams)i.tooltip.bind(this.inputs[t].captionLabel,e(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&C.Cn.getOrCreate(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=C.Cn.getOrCreate(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?C.Cn.getOrCreate(t):null,s=this.inputs.start.input,n=this.inputs.end.input;for(let t=s.options.length-1;t>=0;--t)s.options.remove(t);for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),i=document.createElement("option");e.text=i.text=t,e.value=i.value=t,s.options.add(e),n.options.add(i)}s.value=e?.posList[0]??"",n.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(".regions"):null,s=e?JSON.parse(e):null,n=this.inputs.region.input;for(let t=n.options.length-1;t>=0;--t)n.options.remove(t);const i=document.createElement("option");if(i.text="",i.value=JSON.stringify(null),n.options.add(i),null!=s){this.inputs.region.root.style.removeProperty("display");for(const t of s){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),n.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",s=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let n=t.options.length-1;n>=0;--n){const i=t.options[n],r=JSON.parse(i.value);r&&e===r.start&&s===r.end&&(t.selectedIndex=n)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,s=this.inputs.sequence.value,n=this.inputs.start.stringValue??"",i=this.inputs.end.stringValue??"";return null!=e?`${s.name}(${e.name}): ${e.start}-${e.end}`:`${s?.name}: (${n}-${i})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=i.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});i.dialog({title:"Get Region"}).add(t).onOK((async()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{ze.handleErrorUI(t)}))})).show()}widget(){const t=i.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=i.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{ze.handleErrorUI(t)}))}));return r.Widget.fromRoot(i.divV([t,i.div(e)]))}}const ze=new Ae;function qe(){return Zt.NT.instance}let Xe=null;class $e{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function Ke(){const t=await n.functions.call("Chem:getRdKitModule");await Promise.all([(async()=>{await Zt.NT.instance.loadLibraries()})(),(async()=>{const t=await ze.getProperties(),e=new Me(t);ze.properties=e})()]).finally((()=>{ze.completeInit()}));const e=Zt.NT.instance.getBioLib(),s=[],i=[],r=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(r).forEach((e=>{s.push(e);const n=r[e].replaceAll("#R","O "),o=t.get_mol(n),a=JSON.parse(o.get_descriptors()).CrippenClogP;i.push(a),o?.delete()}));const o=i.reduce(((t,e)=>t+e),0)/i.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=i[t]<o?"#4682B4":"#DC143C";Xe=new $e(a)}function je(t){const e=new Ne(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();n.shell.error(e)})),e}function Je(){return Zt.NT.instance.getBioLib()}function Qe(t){const e="getRegionTopMenu",s=r.Func.find({package:ze.name,name:e});if(1!==s.length)throw new Error(`Package '${ze.name}' func '${e}' not found`);const n=s[0].prepare({table:t.dataFrame,sequence:t});return new Ye(n).widget()}async function ts(t){return(0,Zt.cf)()}function es(t){try{new Ye(t).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;n.shell.error(`Get region editor error: ${e}`),ze.logger.error(e,void 0,s)}}function ss(t){const e=new ye;i.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function ns(t){const e=new Xt(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function is(t){const e=new $t(r.SEMTYPE.MACROMOLECULE);i.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function rs(t){const e=new Ee(t);return e.init().then(),e}function os(){return new x}function as(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===r.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=i.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:f.short,[f.short,f.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const n=parseInt(t.getTag(d.maxMonomerLength)),o=i.intInput("Max monomer length",isNaN(n)?ze.properties.MaxMonomerLength:n,(e=>{t.setTag(d.maxMonomerLength,e.toString()),t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));o.setTooltip(`The max length of monomer name displayed without shortening in '${f.short}' monomer width mode.`);const a=i.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));a.setTooltip("The size of margin between monomers (in pixels)");const l=i.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Color code");const h=i.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const c=i.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));c.setTooltip('When on, all sequences get rendered in the "diff" mode');const u=i.inputs([s,o,a,h,l,c]);return new r.Widget(u)}(t)}function ls(t){return function(t){const e=i.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let n=w.UE.Color;switch(s){case"DNA":case"RNA":n=(0,b.py)("DNA");break;case"PT":n=(0,b.py)("PT")}const o=new Map;let l=0;const h=C.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=o.get(t)||0;o.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},m=Array.from(o.entries());m.sort(((t,e)=>e[1]-t[1])),m.forEach((([t,e])=>{const s=e/c,r=n.get(t),o=i.div("",{classes:"macromolecule-cell-comp-analysis-bar"});o.style.width=s/l*50+"px";const a=i.div((100*s).toFixed(2)+"%");o.style.backgroundColor=r,u[t]=i.div([o,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const d=i.tableFromMap(u);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(d),new r.Widget(e)}(t)}function hs(){return new x}function cs(){return new I}function us(t,e,s,n,i){const r=new D.k(n,i,s,e);return"Local alignment"==t?r.smithWaterman():r.needlemanWunch()}function ms(){return new k.OZ}function ds(){return new H}function ps(t,e,s,n){return Be(t,e??null,s??null,n??null)}async function gs(t,e,s,i,r){const o=Be(e,s??null,i??null,r??null);e.dataFrame.columns.add(o),await n.data.detectSemanticTypes(e.dataFrame)}async function fs(t,e,o,a,l,h){if(!(0,pe.n)(e,"Activity Cliffs"))return;const c=z(t),u={units:e.getTag(r.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},m=C.Cn.getOrCreate(e);let d=Ct.gk.Tanimoto,p=e;if(m.isFasta()||m.isSeparator()&&m.alphabet&&"UN"!==m.alphabet)if(m.isFasta())d=m.getDistanceFunctionName();else{p=m.convert(b.r2.FASTA);const t=C.Cn.getOrCreate(p);d=t.getDistanceFunctionName(),u.units=b.r2.FASTA}const g=async()=>await async function(t,e,o,a,l,h,c,u,m,d,p,g,f,y,b,w,C,v){ct++;const S=c/100,T=o??e;let M=!1,A=!1;const E={};let x,I;const 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g();i.dialog().add(i.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=r.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),e=await g();return t.close(),e})).show()}}async function ys(t,e,s,o=Ct.gk.Tanimoto,a,l){if(await(0,Ut.gw)(10),!(0,pe.n)(e,"Sequence space"))return;const h=z(t),c=r.DataFrame.fromColumns([e]).clone(),u=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),n=[...e.getRawData()],i=[];let r=0;for(let e=0;e<t.rowCount;e++)s.includes(n[e])&&(t.rows.removeAt(e-r),i.push(e),r+=1);return i}(c,e),m={seqCol:c.col(e.name),methodName:s,similarityMetric:o,embedAxesNames:h,options:l},d=s===Yt.AL.UMAP?1e5:15e3,p=s===Yt.AL.UMAP?5e3:2e3;if(t.rowCount>d)n.shell.warning(`Too many rows, maximum for sequence space is ${d}`);else{if(!(t.rowCount>p))return g(await Y(m));i.dialog().add(i.divText("Sequence space analysis might take several minutes.\n Do you want to 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t=n.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==r.SEMTYPE.MACROMOLECULE&&(C.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,pe.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});n.shell.tv.dockManager.dock(s,r.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let o=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),n=e.find((t=>C.Cn.getOrCreate(t).isMsa())),r=i.choiceInput("Column",n?n.name:t[0],t);i.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(i.div([r])).onOK((async()=>{const t=e.find((t=>t.name==r.value))??null;t&&await s(t)})).show()}else o=e[0];o&&await s(o)}else n.shell.error("Current table does not contain sequences")}function Ss(t){return new _t.i(t).importFasta()}function Ts(t){return console.log(t),[]}function Ms(){const t=(0,Pt.B)()[0];(0,It.O)(t)}function As(){return new Te}async function Es(t){const e=r.TaskBarProgressIndicator.create("Test 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t=new URLSearchParams(window.location.search),e=new Ze(t,"getRegionApp");await e.init()}finally{t.close()}}async function Ds(){const t=r.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await ze.files.readCsv("data/sample_HELM_empty_vals.csv"),s=new Ze(t,"getRegionHelmApp");await s.init({df:e,colName:"HELM"})}finally{t.close()}}function Bs(t,e){!function(t,e){const s=C.Cn.getOrCreate(t.column),i=Object.values(b.r2).filter((t=>t!==s.units));e.group("Copy").items(i,(e=>{const s=C.Cn.getOrCreate(t.column),i=e===b.r2.SEPARATOR?ze.properties.DefaultSeparator:void 0,r=s.getConverter(e,i)(t.value);navigator.clipboard?(navigator.clipboard.writeText(r),n.shell.info(`Value of notation '${e}' copied to clipboard`)):n.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function Us(){await async function(){let t,e;try{const s=new ee("Similarity, Diversity","Sequence similarity 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Promise.all([ze.files.readCsv(ae),re(),oe()]),s=n.shell.addTableView(i),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{o=await async function(t,e,s,n){let i;{const t=Object.values(Qt);for(let s=0;s<t.length;s++){const n=t[s];if(!e.col(n)){const i=s==t.length-1;e.columns.add(r.Column.float(n,e.rowCount),i)}}if(e.rowCount>=1){const n=e.getCol(s).toList(),i=Date.now();ze.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const r=await(0,B.I)(n,"UMAP",Ct.W.Levenshtein,{}),o=Date.now();ze.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(o-i)/1e3} s`);for(let s=0;s<t.length;s++){const n=t[s],i=e.getCol(n),o=r.embedding[s];i.init((t=>o[t]))}const a=Date.now();ze.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-o)/1e3} s`)}i=await e.plot.fromType(r.VIEWER.SCATTER_PLOT,{xColumnName:Qt.X,yColumnName:Qt.Y,lassoTool:!0})}return t.dockManager.dock(i,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),i}(s,i,le)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const n=i.getCol(le).toList(),r=lt.H.calc(n,((t,e)=>ie.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(s.grid,o,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{i.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=i.getCol("sequence_id");i.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),i.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){se(t)}}()}async function Ys(){await async function(){let t,e,s,i,o;const a=Yt.AL.UMAP;try{const l=new ee("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([ze.files.readCsv(ue),re(),oe()]),i=n.shell.addTableView(s),i.grid.props.rowHeight=22,i.grid.columns.byName("cluster").visible=!1,i.grid.columns.byName("sequence").width=300,i.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{o=await fs(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),i.dockManager.dock(o,r.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),ce()(o.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const n=s.getCol("sequence").toList(),r=lt.H.calc(n,((t,e)=>ie.T(t,e)/((t.length+e.length)/2))),o=await t.hierarchicalClusteringByDistance(r,"ward");e.injectTreeForGrid(i.grid,o,void 0,150,void 0),i.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=o.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){se(t)}}()}async function zs(){await async function(){const t="HELM";let e,s,o;try{await new ee("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1,e=await ze.files.readCsv("samples/HELM.csv"),s=n.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const n=s.grid.columns.byIndex(e);[t,"Activity"].includes(n.name)||(n.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await bs(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const n=e.currentCell.value,a=new r.chem.Sketcher(r.chem.SKETCHER_MODE.INPLACE);a.setMolFile(n),o=i.dialog().add(a).show(),await(0,Ut.gw)(3e3),o.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){se(t)}}()}async function qs(){await async function(){let t,e,s,i,o,a;const l="msa(HELM)",h=Yt.AL.UMAP;try{const c=new ee("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=n.shell.addTableView(e=await ze.files.readCsv(de)),n.shell.windows.showContextPanel=!1,n.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=me.J[0];i=await(0,me.f)(s,l,t,1.53,0,void 0),e.columns.add(i),await n.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await ys(e,i,h,Z.U.LEVENSHTEIN,!0),t.dockManager.dock(a,r.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{o=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(o,r.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){se(t)}}()}async function Xs(t,e){var s;Oe(s=e),s.setTag("units",b.r2.SEPARATOR),s.setTag("separator","-"),await n.data.detectSemanticTypes(t)}function $s(t){return function(t){function e(t){return t===c[0]?[Re].concat(m.getMonomerSymbolsByType("PEPTIDE")):t===c[1]?[Re].concat(m.getMonomerSymbolsByRGroup(3,"PEPTIDE")):["C"]}function s(){"N-Cys"===u.value?(d=e("N-O"),p=e("N-Cys")):(d=e(u.value),p=[...d]),g=i.choiceInput("R1:",d[0],d,(()=>{o.next()})),f=i.choiceInput("R2:",p[0],p,(()=>{o.next()})),o.next(),i.empty(y),[g,f].forEach((t=>{y.appendChild(t.root)}))}const n=new R.Subject,o=new R.Subject;n.subscribe((()=>{a.cyclizationType=u.value,s()})),o.subscribe((()=>{a.rightTerminal=f.value,a.leftTerminal=g.value}));const a={},l=["Cyclization"],h=i.choiceInput("Modification",l[0],l,(()=>a.transformationType=h.value)),c=["N-O","R3-R3","N-Cys"],u=i.choiceInput("Type",c[0],c,(()=>{n.next()})),m=Zt.NT.instance.getBioLib();let d=[],p=[],g=i.choiceInput("R1:",d[0],d,(()=>{a.leftTerminal=g.value})),f=i.choiceInput("R2:",p[0],p,(()=>{a.rightTerminal=f.value}));const y=i.divV([g.root,f.root]);s(),a.cyclizationType=u.value,a.leftTerminal=g.value,a.rightTerminal=f.value,a.transformationType=h.value;const b=i.bigButton("Run",(async()=>De(t,a))),w=i.div([h,u,y,b]);return new r.Widget(w)}(t)}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>r});class n{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class i{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class r{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",n="",r="";const o=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)r+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=r+s,n=this.seq2.substr((e-1)*this.step,this.step)+n):this.dpGrid[t][e].parentJ==e?(n=r+n,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:r+s,n=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+n:r+n);const i=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[i][e].parentJ}return new i(s,n,o)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new n);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let n=1;n<=this.len1;n++)for(let i=1;i<=this.len2;i++)this.fillOne(n,i),this.dpGrid[n][i].value<=0?(this.dpGrid[n][i].value=0,this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0):0==this.dpGrid[this.dpGrid[n][i].parentI][this.dpGrid[n][i].parentJ].value&&(this.dpGrid[n][i].parentI=0,this.dpGrid[n][i].parentJ=0),this.dpGrid[n][i].value>t&&(t=this.dpGrid[n][i].value,e=n,s=i);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,n=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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t=n.shell.tv.dataFrame,e={filter:t=>t.semType===r.SEMTYPE.MACROMOLECULE};this.columnsInput=i.columnInput("Column",t,this.col,(t=>{this.col=t,this.updateNotationDiv(),this.updateInputs()}),e),this.substructureInput=i.stringInput("Substructure",""),this.editHelmLink=i.link("Edit helm",(()=>this.editHelmLinkAction()),void 0,{style:{position:"relative",left:"95px"}});const s=r.DataFrame.create(1);s.columns.addNewString(c).init((t=>"")),s.col(c).semType=this.col.semType,s.col(c).setTag(r.TAGS.UNITS,h.r2.HELM),this.grid=s.plot.grid(),this.separatorInput=i.stringInput("Separator",this.separator),this.inputsDiv=i.div(),this.units=this.col.getTag(r.TAGS.UNITS),this.separator=this.col.getTag("separator"),this.updateInputs(),this.dialog=i.dialog("Substructure Search").add(i.divV([i.divText(`Notation: ${this.units}`,"notation-text"),this.inputsDiv])).onOK((async()=>{let t,e=this.units===h.r2.HELM?s.get(c,0):this.substructureInput.value;this.units===h.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(e=e.replaceAll(this.separatorInput.value,this.separator)),t=this.units===h.r2.HELM?await d(e,this.col):m(e,this.col),this.col.dataFrame.filter.and(t)})).show()}}function m(t,e,s){const n=s?function(t,e){const s=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),n=t.charAt(0)===e,i=t.charAt(t.length-1)===e,r=t.replace(new RegExp(`^${s}|${s}$`,"g"),"");return n?i?`${s}${r}${s}`:`${s}${r}${s}|${s}${r}$`:i?`^${r}${s}|${s}${r}${s}`:`^${r}${s}|${s}${r}${s}|${s}${r}$`}(t,s):t,i=r.BitSet.create(e.length);for(let s=0;s<e.length;s++){const r=e.get(s);(r.match(n)||r===t)&&i.set(s,!0,!1)}return i}async function d(t,e){e.version!==e.temp["last-invalidated-version"]&&await p(e,!0);const s=r.Column.string("helm",1).init((e=>t));s.semType=r.SEMTYPE.MACROMOLECULE,s.setTag(r.TAGS.UNITS,h.r2.HELM);const i=await(0,o.D)(s,!0,e.temp["monomers-dict"]);return(await n.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:i.get(0),molBlockFailover:""})).get(0)}async function p(t,e){const s=r.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const n=new Map,i=await(0,o.D)(t,e,n);t.temp["monomeric-mols"]=i,t.temp["monomers-dict"]=n,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>o});var n=s(4469),i=s(976),r=s(499);function o(t,e,s=[],o=[],a=!0){const[l,h]=function(t,e,s=[],o=[]){let a=!0,l="";const h=r.Cn.getOrCreate(t);if(t.semType!==i.SEMTYPE.MACROMOLECULE)n.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;o.length>0&&!o.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==o.length?"any alphabet":`alphabet${o.length>1?"s":""} ${o.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,o);return a&&!l&&n.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>r,WY:()=>h,jB:()=>c,rs:()=>a});var n,i,r,o,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(n||(n={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(i||(i={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(r||(r={})),function(t){t.CELL_CHANGING="isCellChanging"}(o||(o={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>m});var n=s(976),i=s(3870),r=s(4469),o=s(3336),a=s.n(o),l=s(8447),h=s(499);let c=null,u=[];function m(t){let e=t??r.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=h.Cn.getOrCreate(e),o=s.notation;const m=i.divText("Current notation: "+o,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),d=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],p=i.columnInput("Column",r.shell.t,e,(t=>{t.semType===n.SEMTYPE.MACROMOLECULE?(e=t,s=h.Cn.getOrCreate(e),o=s.notation,o===l.r2.HELM&&(y.value="/"),m.textContent="Current notation: "+o,f=d.filter((t=>t!==o)),w=i.choiceInput("Convert to",f[0],f,b),b(),c?.clear(),c?.add(i.div([m,p.root,w.root,y.root]))):p.value=e})),g=["-",".","/"];let f=d.filter((t=>t!==o));const y=i.choiceInput("Separator",g[0],g),b=()=>{w.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let w=i.choiceInput("Convert to",f[0],f,b);b(),w.onChanged((()=>{b()})),null==c&&(c=i.dialog("Convert Sequence Notation").add(i.div([m,p.root,w.root,y.root])).onOK((async()=>{const t=w.value,s=y.value??void 0;await async function(t,e,s){const n=h.Cn.getOrCreate(t).convert(e,s);t.dataFrame.columns.add(n);const i=await r.functions.call("Bio:detectMacromolecule",{col:n});return i&&(n.semType=i),await r.data.detectSemanticTypes(t.dataFrame),n}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},5490:(t,e,s)=>{"use strict";s.d(e,{NT:()=>M,cf:()=>S});var n,i=s(4469),r=s(3870),o=s(976),a=s(701);class l{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let s=t;const n=this.isWhitespace(s)?e:e-1;for(let t=0;t<n;t++)s=this.getNextColumnIdx(s);return s}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let s=this.getAtomBlockIdx();for(let n=0;n<t;n++)s=this.shiftIdxToAtomType(s),e[n]=this.parseAtomType(s),s=this.getNextLineIdx(s);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),s=new Float32Array(this.atomCount);let n=this.getAtomBlockIdx();for(let i=0;i<this.atomCount;i++){n=this.shiftIdxToXColumn(n);for(const r of[t,e,s])r[i]=this.parseFloatValue(n),n=this.getNextColumnIdx(n);n=this.getNextLineIdx(n)}return{x:t,y:e,z:s}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let s=0;s<this.bondCount;s++){e=this.shiftIdxToBondedAtomsPair(e);const n=new Uint16Array(2);n[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),n[1]=this.parseIntValue(e),t[s]=n,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let s=this.getBondBlockIdx();for(let n=0;n<t;n++)s=this.shiftIdxToBondType(s),e[n]=this.parseIntValue(s),s=this.getNextLineIdx(s);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let s=e+1;for(;!this.isWhitespace(s);)++s;return t(this.fileContent.substring(e,s))}}class h extends l{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,s=e;return this.isQuote(e)?(s=this.getNextIdenticalChar(e),e++):s=this.fileContent.indexOf(" ",s),this.fileContent.substring(e,s)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((s=this.fileContent.charCodeAt(e+1))>64&&s<91||s>96&&s<123);var s}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let s=this.getAtomBlockIdx();for(let n=0;n<e;n++){if(s=this.shiftIdxToAtomType(s),t(this.fileContent.charCodeAt(s),s))return!0;s=this.getNextLineIdx(s)}return!1}}!function(t){t.HEADER="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t.RGP_LINE="M RGP",t.A_LINE="A ",t.END="M END"}(n||(n={}));class c extends h{constructor(t){super(t)}static validate(t){return-1!==t.indexOf(n.HEADER)&&-1!==t.indexOf(n.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,n.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<n.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,n.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,n.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+n.NUM_OF_COUNTS_DIGITS;const s=parseInt(this.fileContent.substring(t,e));return t=e,e+=n.NUM_OF_COUNTS_DIGITS,{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class u extends h{constructor(t){super(t),this.init(t)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static validate(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const s=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class m{constructor(){}static getInstance(t){if(c.validate(t))return new c(t);if(u.validate(t))return new u(t);throw new Error("Malformed molfile")}}var d=s(7228),p=s(2397);const g="Libraries",f="System:AppData/Bio/libraries/";async function y(){return await Promise.all((await i.dapi.files.list(f,!0,"")).map((async t=>t.fullPath.substring(f.length))))}let b=Promise.resolve();async function w(){let t;return b=b.then((async()=>{const e=await i.dapi.userDataStorage.getValue(g,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await b,t}async function C(t){b=b.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await i.dapi.userDataStorage.postValue(g,"Settings",JSON.stringify(t),!0)})),await b}async function v(){const t=r.dialog({title:"Manage files"}).add(r.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function S(){const t=r.button("Manage",v),e=r.inputs([]),s=await y(),n=await w();for(const t of s){const s=r.boolInput(t,!n.exclude.includes(t),(()=>{1==s.value?n.exclude=n.exclude.filter((e=>e!=t)):n.exclude.includes(t)||n.exclude.push(t),C(n).then((async()=>{await M.instance.loadLibraries(!0),i.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new o.Widget(r.divV([e,r.div(t)]))}class T{constructor(t,e){this._monomers={},this._onChanged=new a.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}getMonomerSymbolsByRGroup(t,e,s){let n=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return n=n.filter((t=>null!==t)),0===n.length?[]:(n=n.filter((e=>{if(!e?.rgroups)return!1;let s=e?.rgroups.length>=t;return m.getInstance(e.molfile).atomTypes.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),s&&(s=!0),s})),n.map((t=>t?.symbol)))}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class M{constructor(){this._monomerLib=new T({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([y(),w()]),n=e.filter((t=>!s.exclude.includes(t))),i=await Promise.all(n.map((t=>this.readLibrary(f,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new T({},s)})))));this._monomerLib.updateLibs(i,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;i.shell.warning(e);const s=t instanceof Error?t.stack:void 0;p._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,n,r=[];const a=new o.FileSource(t);if(e.endsWith(".sdf"))1===o.Func.find({package:"Chem",name:"importSdf"}).length?(s=await a.readAsBytes(e),n=await i.functions.call("Chem:importSdf",{bytes:s}),r=(0,d.Xk)(n[0])):i.shell.warning("Chem package is not installed");else if(e.endsWith(".json")){const t=await a.readAsText(e);r=JSON.parse(t)}else{if(!e.endsWith(".csv"))throw new Error("Monomer library of unknown file format, supported formats: SDF, JSON, CSV");{const t=(l=await a.readCsv(e),Array.from({length:l.rowCount},((t,e)=>l.columns.names().reduce(((t,s)=>(t[s]=l.get(s,e),t)),{}))));if(!(0,d.eD)(t))throw new Error("Invalid format of CSV monomer lib");r=(0,d.Z)(t)}}var l;const h={},c=[];return r.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new T(h)}static get instance(){return M._instance||(M._instance=new M),M._instance}}M._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>I});var n=s(4469),i=s(976),r=s(3870),o=s(8447),a=s(499),l=s(6098),h=s(8341),c=s(2568),u=s(3553),m=s(2397),d=s(3379),p=s.n(d),g=s(7795),f=s.n(g),y=s(569),b=s.n(y),w=s(3565),C=s.n(w),v=s(9216),S=s.n(v),T=s(4589),M=s.n(T),A=s(9564),E={};E.styleTagTransform=M(),E.setAttributes=C(),E.insert=b().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),p()(A.Z,E),A.Z&&A.Z.locals&&A.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async function I(t={}){return new Promise((async(e,s)=>{var 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n=["NH2","COOH"];if(t.startsWith(n[0])){const s=n[0].length;(0,x.hu)("-"==t[s],`Wrong sequence format: ${n[0]} without following '-' in '${t}'.`),e=s}if(t.endsWith(n[1])){const e=n[1].length+1;(0,x.hu)("-"==t[s-e],`Wrong sequence format: ${n[1]} without '-' precending in '${t}'.`),s-=e}return t.substring(e,s)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return N._dropDefises(N._truncateSequence(t))}encode(t){const e=t.length,s=new Array(e).fill(0);for(let n=0;n<e;++n){const e=t[n];(0,x.hu)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),s[n]=this.encodeLettter(e)}return s}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let s=0;s<t.length;++s){const n=t[s];(0,x.hu)(n in this.num2aa,`Unknown code '${n}' found in vector '${t}'`),e+=this.num2aa[n]}return e}}var L=s(3553);const _="input.fa",R="result.fasta";function O(t){return t.reduce(((t,e,s)=>t+`>sample${s+1}\n${e}\n`),"")}async function P(t,e=!1,s="",r=null,o,a,l){let h=t.toList();e&&(h=h.map((t=>N.clean(t).replace(/\-/g,""))));const c=t.length;r??(r=n.Column.string("Clusters",c).init("0")),r.type!=n.COLUMN_TYPE.STRING&&(r=r.convertTo(n.TYPE.STRING)),r.compact();const u=r.categories,m=r.getRawData(),d=new Array(u.length),p=new Array(u.length);for(let t=0;t<c;++t){const e=m[t];(d[e]??(d[e]=[])).push(h[t]),(p[e]??(p[e]=[])).push(t)}const g=await new E(["base/1.0.0",{tool:"kalign",version:L.WY,reinit:!0}]),f=n.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(d[t]);await g.fs.writeFile(_,e);const s=`${void 0!==o?` --gpo ${o}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,n=await g.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(n);const r=await g.cat(R);if(!r)throw new Error("kalign output no result");const h=new i.i(r).sequencesArray,c=p[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(n.TAGS.UNITS),b=t.getTag("alphabet");return f.setTag(n.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",b),f.semType=n.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var n=s(4469),i=s(976),r=s(8447),o=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const m=await n.dapi.docker.dockerContainers.filter("bio").first();if("started"!==m.status&&"checking"!==m.status)return n.log.warning("PepSeA container has not started yet"),null;const d=t.length;u??(u=i.Column.int("Clusters",d).init(0)),u.type!=i.COLUMN_TYPE.STRING&&(u=u.convertTo(i.TYPE.STRING));const p=u.categories,g=new Array(p.length);for(let e=0;e<d;++e){const s=u.get(e);if(""===s)continue;const n=p.indexOf(s),i=t.get(e);i&&(g[n]??(g[n]=[])).push({ID:e.toString(),HELM:i})}const f=new Array(d);for(const t of g){const e=(await c(m.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(o.rs.SEPARATOR)}const y=i.Column.fromStrings(e,f);return y.setTag(i.TAGS.UNITS,r.r2.SEPARATOR),y.setTag("separator",o.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=i.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,i,r){const o={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${i}&gap_extend=${r}`,l=await n.dapi.docker.dockerContainers.request(t,a,o);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var n=s(976),i=s(3870),r=s(4469),o=s(6414),a=s.n(o),l=s(8447),h=s(499);const c=60;function u(){const t=r.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==n.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),o=s?[s.name]:[],u=i.multiChoiceInput("Seq id columns",o,e.map((t=>t.name))),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==n.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),p=d.length>0?d[0].name:[],g=i.choiceInput("Seq column",p,d.map((t=>t.name))),f=i.intInput("FASTA line width",c);i.dialog({title:"Save as FASTA"}).add(i.inputs([u,g,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=g.value?t.columns.byName(g.value).column:null,n=f.value??c;s||r.shell.warning("Seq column is mandatory to save as FASTA.");const i=function(t,e,s=c,n="\n"){const i=l.kB,r=[];for(let o=0;o<e.length;o++){const a=t.map((t=>t.get(o).toString())).join("|"),l=m(e.get(o),i,s);r.push(`>${a}${n}`);for(const t of l)r.push(`${t}${n}`)}return"".concat(...r)}(e,s,n),o=document.createElement("a");o.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(i)}`),o.setAttribute("download",`${t.dataFrame.name}.fasta`),o.click()})).show()}function m(t,e,s=c){const n=e(t);let i=0;const r=n.length,o=[];for(;i<r;){const t=a()(n).slice(i,i+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");o.push(e),i+=t.length}return o}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var n=s(4469),i=s(976),r=s(1061),o=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,r.gw)(10),!(0,o.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const n=s.columns.byIndex(t);n.semType=l.Of.MONOMER,n.setTag("alphabet",e.getTag("alphabet"));const i=100;let r=0;for(;h.columns.byName(n.name)&&r<i;)n.name=u(n.name),r++;h.columns.add(n)}await n.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++)s.columns.byIndex(t).setTag(i.TAGS.CELL_RENDERER,"Monomer");return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>r,Y:()=>o});var n=s(4469),i=s(976);function r(){const t=n.shell.t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);if(null!==t)return t;n.shell.error("Current table does not contain macromolecules")}function o(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>p,OZ:()=>C});var n=s(4469),i=s(3870),r=s(976),o=s(6414),a=s.n(o),l=s(701),h=s(499),c=s(8447),u=s(9298);function m(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?m(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var d,p,g=s(2397);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new r.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},r.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class f{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,n){this.pos=t,this.name=e,this._freqs=s??{},n?.rowCount&&(this.rowCount=n.rowCount),n?.sumForHeightCalc&&(this.sumForHeightCalc=n.sumForHeightCalc),n?.label&&(this._label=n.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new f),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,n])=>n.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,n,i,o,a,l,h,c){const m=i==u.ES.Entropy?n*(o-this.sumForHeightCalc)/o:n;let d=c*h+(n-m-1);const p=Object.entries(this._freqs).sort(((e,s)=>t(e[0])||t(s[0])?t(e[0])&&t(s[0])?0:t(e[0])?-1:1:s[1].count-e[1].count));for(const t of p){const n=t[1],i=m*n.count/this.rowCount;n.bounds=new r.Rect((e-s)*h*a,d,l*h,i),d+=i}}render(t,e,s,n,i,r){for(const[o,a]of Object.entries(this._freqs))if(!e(o)){const e=(0,c.GU)(o,5),l=a.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=r.get(o)??r.get("other"),t.textAlign="left",t.font=s;const u=t.measureText(e);t.setTransform(l.width/u.width,0,0,l.height/i,h,l.top),t.fillText(e,0,-n)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(p||(p={}));const b=u.vS;var w;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(w||(w={}));class C extends r.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get filter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=this.dataFrame.selection}return t}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.renderLevelRequested=w.Freqs,this.viewerId=C.viewerCount,C.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(p.sequenceColumnName,b.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(p.startPositionName,b.startPositionName,{category:d.DATA}),this.endPositionName=this.string(p.endPositionName,b.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(p.skipEmptySequences,b.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(p.skipEmptyPositions,b.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(p.shrinkEmptyTail,b.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(p.backgroundColor,b.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(p.positionHeight,b.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(p.positionWidth,b.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(p.verticalAlignment,b.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(p.horizontalAlignment,b.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(p.fixWidth,b.fixWidth,{category:d.LAYOUT,userEditable:!1}),this.fitArea=this.bool(p.fitArea,b.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(p.minHeight,b.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(p.maxHeight,b.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(p.showPositionLabels,b.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(p.positionMarginState,b.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(p.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(p.filterSource,b.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=i.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=i.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){this.setDataInProgress||(this.setDataInProgress=!0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.setData() `),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView(),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.updateSeqCol()})).then((async()=>{this.viewed||(await this.buildView(),this.viewed=!0)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),this.viewSubs.forEach((t=>t.unsubscribe())),this.host.remove(),this.msgHost=void 0,this.host=void 0,g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=i.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=i.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=i.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,i.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(i.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(w.Freqs,"buildView"),g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(w.Layout,"rootOnSizeChanged").then((()=>{}))}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,e=a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(".positionNames"),n=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(c.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=n?n.split(c.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(w.Freqs,"updatePositions").then((()=>{}))}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t))}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,this.Length-1,0,this.Length-1),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${n}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${n}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${n+6}px`),this.host.style.width=`${this.host}px`;const i=e>n;if(this.setSliderVisibility(i),i){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=n*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),n=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,i=this.root.clientHeight/s,r=Math.max(1,Math.min(n,i));this._positionWidth=this.positionWidth*r,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const o=(this._positionWidth+this.positionMarginValue)*this.Length,a=r*s,l=Math.min(this.root.clientWidth,o);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=o>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,this.Length-.001,t,e)}else this.slider.setValues(0,this.Length-.001,0,this.Length-.001);this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case p.sequenceColumnName:this.updateSeqCol();break;case p.sequenceColumnName:case p.startPositionName:case p.endPositionName:case p.filterSource:case p.shrinkEmptyTail:case p.skipEmptyPositions:case p.positionHeight:this.updatePositions();break;case p.minHeight:case p.maxHeight:case p.positionWidth:case p.showPositionLabels:case p.fixWidth:case p.fitArea:case p.horizontalAlignment:case p.verticalAlignment:case p.positionMargin:case p.positionMarginState:this.render(w.Layout,`onPropertyChanged(${t.name})`).then((()=>{}));break;case p.backgroundColor:this.render(w.Render,`onPropertyChanged(${t.name})`).then((()=>{}))}}onTableAttached(){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){if(this.setDataInProgress)return;g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.detach(), `);const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView(),this.viewed=!1),t()}))}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,n=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),i=this.positions[n];if(void 0===i)return[n,null,null];const r=i.getMonomerAt(s,t.y);return void 0===r?[n,null,null]:[n,r,i.getFreq(r)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>{const e=this.unitsHandler.defaultGapSymbol;return!t.hasMonomer(e)||t.getFreq(e).count!==t.rowCount})).toArray())}render(t,e){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${t}, reason='${e}' )`);const s=()=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.filterSource===u.Ct.Filtered?this.dataFrame.filter:this.dataFrame.selection,n=this.dataFrame.rowCount,i=this.unitsHandler.splitted;for(let e=0;e<n;++e)if(s.get(e)){const s=i[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||this.unitsHandler.defaultGapSymbol;this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()},i=(t,e)=>{g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `),this.calcLayout(t);const s=this.canvas.height-e*t,i=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==i&&n.shell.error("WebLogo: alphabet is undefined.");const r=Math.log2(i);for(let n=Math.floor(this.slider.min);n<=Math.floor(this.slider.max);++n)n in this.positions?this.positions[n].calcScreen((t=>this.unitsHandler.isGap(t)),n,this.slider.min,s,this.positionHeight,r,this._positionWidthWithMargin,this._positionWidth,t,e):console.warn(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${n}`);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()},o=t=>{if(g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||-1===this.startPosition||-1===this.endPosition||null==this.host||null==this.slider)return;const e=this.canvas.getContext("2d");if(!e)return;this.slider.root.style.width=`${this.host.clientWidth}px`;const n=window.devicePixelRatio,o=this.showPositionLabels?12:0;if(t>=w.Freqs&&s(),0===this.positions.length)return;t>=w.Layout&&i(window.devicePixelRatio,o),this.Length,e.resetTransform(),e.fillStyle=function(t){const e=r.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),e.fillRect(0,0,this.canvas.width,this.canvas.height),e.textBaseline=this.textBaseline;const a=10*n;e.resetTransform(),e.fillStyle="black",e.textAlign="center",e.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>e.measureText(t.name).width))),h=l<this._positionWidth*n-2?1:(this._positionWidth*n-2)/l;o>0&&function(t,e,s,n,i,r,o,a){for(let l=Math.floor(o);l<=Math.floor(a);l++){const a=r[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-o)*n*e+i*e/2,0),t.fillText(a.label,0,1)}}(e,n,h,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(e,(t=>this.unitsHandler.isGap(t)),"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};return this.renderLevelRequested=Math.max(this.renderLevelRequested,t),new Promise(((t,e)=>{window.setTimeout((()=>{try{if(this.renderLevelRequested>w.None)try{o(this.renderLevelRequested)}finally{this.renderLevelRequested=w.None}}catch(t){e(t)}}),0)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(w.Layout,"sliderOnValuesChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(w.Freqs,"dataFrameFilterOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){g._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===u.Ct.Selected&&this.render(w.Freqs,"dataFrameSelectionOnChanged").then((()=>{}))}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,n=this.canvas.getCursorPosition(s,e),[r,o]=this.getMonomer(n,e);if(this.dataFrame&&this.seqCol&&o){const t=this.positions[r],e=function(t,e,s,n,i){let r=0,o=-1;for(;-1!=(o=s.findNext(o,!0));){const t=e.splitted[o],s=i.pos;(s<t.length?t[s]:null)===n&&r++}return r}(this.dataFrame,this.unitsHandler,this.filter,o,t),n=i.div([i.div(`${o}`),i.div(`${e} rows`)]);i.tooltip.show(n,s.x+16,s.y+16)}else i.tooltip.hide()}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[n,i]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&i){const t=this.positions[n],e=r.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,n,i,r){const o=e.splitted[n],a=r.pos<o.length?o[r.pos]:null;return a===i||""===a&&i===e.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.filter,e,i,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),n=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+n)}catch(t){const e=m(t);g._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+e)}}}C.residuesSet="nucleotides",C.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>p});var n=s(3870),i=s(976),r=s(4469),o=s(6414),a=s.n(o),l=s(7983),h=s(701),c=s(4293),u=s(8447),m=s(1061);const d=rxjs.operators;class p extends i.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=n.loader(),this.notation=void 0,this.root=n.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(i.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(i.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new b,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged()))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substrucrureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class g{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substrucrureSearch(t){return null}}class f extends g{constructor(){super(),this.substructureInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t)}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=n.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return n.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substrucrureSearch(t){return await(0,l.pf)(this.substructure,t,this.colSeparator)}}class b extends g{constructor(){super(),this._filterPanel=n.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await r.functions.call("HELM:helmWebEditor"),await n.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);n.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),n.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=n.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substrucrureSearch(t){n.setUpdateIndicator(this._filterPanel,!0),await(0,m.gw)(10);const e=await(0,l.QF)(this.substructure,t);return n.setUpdateIndicator(this._filterPanel,!1),e}}},9378:function(t,e,s){"use strict";var n=this&&this.__importStar||function(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var s in t)Object.hasOwnProperty.call(t,s)&&(e[s]=t[s]);return e.default=t,e};Object.defineProperty(e,"__esModule",{value:!0});var i=n(s(4517));function r(t,e){var s=function(s){return 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t=this.embedding,e=this.embedding,s=this.optimizationState,n=s.head,i=s.tail,r=s.epochsPerSample,o=this.getNEpochs(),a=this.graph.nCols,l=S(this.spread,this.minDist),h=l.a,c=l.b;this.assignOptimizationStateParameters({headEmbedding:t,tailEmbedding:e,head:n,tail:i,epochsPerSample:r,a:h,b:c,nEpochs:o,nVertices:a})},t.prototype.optimizeLayoutStep=function(t){for(var e=this.optimizationState,s=e.head,n=e.tail,i=e.headEmbedding,r=e.tailEmbedding,o=e.epochsPerSample,a=e.epochOfNextSample,l=e.epochOfNextNegativeSample,h=e.epochsPerNegativeSample,c=e.moveOther,u=e.initialAlpha,m=e.alpha,p=e.gamma,g=e.a,f=e.b,y=e.dim,b=e.nEpochs,w=e.nVertices,S=0;S<o.length;S++)if(!(a[S]>t)){var T=s[S],M=n[S],A=i[T],E=r[M],x=v(A,E),I=0;x>0&&(I=-2*g*f*Math.pow(x,f-1),I/=g*Math.pow(x,f)+1);for(var N=0;N<y;N++){var L=C(I*(A[N]-E[N]),4);A[N]+=L*m,c&&(E[N]+=-L*m)}a[S]+=o[S];for(var _=Math.floor((t-l[S])/h[S]),R=0;R<_;R++){var 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