@datagrok/bio 2.10.22 → 2.10.23

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Files changed (13) hide show
  1. package/dist/package-test.js +1 -1
  2. package/dist/package-test.js.map +1 -1
  3. package/dist/package.js +1 -1
  4. package/dist/package.js.map +1 -1
  5. package/package.json +2 -2
  6. package/src/package.ts +4 -4
  7. package/src/tests/WebLogo-positions-test.ts +13 -13
  8. package/src/tests/detectors-benchmark-tests.ts +2 -2
  9. package/src/tests/detectors-tests.ts +4 -1
  10. package/src/utils/cell-renderer.ts +7 -1
  11. package/src/utils/err-info.ts +28 -0
  12. package/src/viewers/vd-regions-viewer.ts +56 -31
  13. package/src/viewers/web-logo-viewer.ts +108 -102
package/dist/package.js CHANGED
@@ -1,3 +1,3 @@
1
1
  /*! For license information please see package.js.LICENSE.txt */
2
- var bio;(()=>{var t={2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>n});var i=s(9976);class n extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,n)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,n)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new n({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in n.aaSynonyms?n.aaSynonyms[t]:t;return super.get(e)}}n.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(t="grok"){switch(t){case"grok":return n.GrokGroups;case"lesk":return n.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",i="";for(const n of t)"("==n?e++:")"==n?e--:e?s+=n:i+=n;return isNaN(parseInt(s))?[i,s]:[i,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[i,n]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,n=n.length>6?`${n.slice(0,3)}...`:n,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,n,1]:[this.undefinedColor,i,n,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,n,2]:[this.undefinedColor,i,n,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,n,3]:[this.undefinedColor,i,n,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,n,4]:[this.undefinedColor,i,n,4]}return[this.undefinedColor,i,n,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>c,PF:()=>m,Qx:()=>u,Xk:()=>h,Z:()=>l,eD:()=>a});var i=s(976),n=s(4469),o=s(1047),r=(s(499),s(8457));function a(t){return t.every((t=>"object"==typeof t&&Object.values(o.pn).every((e=>e in t&&"string"==typeof t[e]))))}function l(t){function e(t){const e=new RegExp("\\[r\\]","g");let s=0;return t.replace(e,(t=>(++s,`[${s}*]`)))}const s=[];return t.forEach((t=>{const n={...o.zh};Object.entries(o.pn).forEach((([e,s])=>{const i=t[s];n[e]=i}));let r="smiles";const a=t[o.pn[r]],l=e(a).replace("[1*]","[H:1]").replace("[2*]","[OH:2]");n[r]=l,r="rgroups",n[r]=o.Ei,r="molfile";const h=e(a),c=i.chem.convert(h,i.chem.Notation.Smiles,i.chem.Notation.MolBlock);n[r]=c.replace("M ISO","M RGP"),s.push(n)})),console.log("resultLib:",s),s}function h(t){const e=[];for(let s=0;s<t.rowCount;s++){const i={};Object.keys(o.K4).forEach((e=>{if("symbol"===e){const n=t.get(o.K4[e],s);i[e]="."===n?t.get(o.At,s):n}else if("rgroups"===e){const n=t.get(o.K4[e],s).split("\n"),r=[];n.forEach((t=>{const e={},s=t.substring(t.lastIndexOf("]")+1),i=t.match(/\[R(\d+)\]/)[1];e.capGroupSmiles="H"===s?`[*:${i}][H]`:`O[*:${i}]`,e.alternateId="H"===s?`R${i}-H`:`R${i}-OH`,e.capGroupName="H"===s?"H":"OH",e.label=`R${i}`,r.push(e)})),i[e]=r}else o.K4[e]&&(i[e]=t.get(o.K4[e],s))})),e.push(i)}return e}async function c(){const t=i.Func.find({package:"Bio",name:"getMonomerLibHelper"});if(0===t.length)throw new Error('Package "Bio" must be installed for MonomerLibHelper.');return(await t[0].prepare().call()).getOutputParamValue()}async function u(t,e){t instanceof i.Column&&(t=(0,r.O)(t).columns.toList());const s=(await c()).getBioLib(),o=new Array(t.length),a=t[0].length,l=new Float32Array(a);for(let r=0;r<t.length;++r){const h=e[r],c=s.getMonomer("PEPTIDE",h)?.smiles??"",u=t[r],m=u.getRawData(),d=u.categories,g=d.indexOf("");if(o[r]={categories:d,data:m,emptyIndex:g},void 0===h)continue;const p=i.Column.fromStrings("smiles",d.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(i.DataFrame.fromColumns([p]),(await n.chem.getSimilarities(p,c)).getRawData());for(let t=0;t<a;++t){const e=m[t];l[t]+=""!==h&&e!==g?f[e]:""===h&&e===g?1:0}}for(let s=0;s<l.length;++s){let n=l[s]/e.length;for(let r=0;r<t.length;++r){const t=o[r];if(r>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&r<e.length){n=i.FLOAT_NULL;break}}l[s]=n}return i.Column.fromFloat32Array("Similarity",l)}async function m(t){const e=(await c()).getBioLib(),s=[],o={},r=t.map((t=>e.getMonomer("PEPTIDE",t)?.smiles??"")),a=i.Column.fromStrings("smiles",r);for(let e=0;e<r.length;++e){o[t[e]]=e;const i=r[e],l=""===i?new Array(r.length).fill(0):(await n.chem.getSimilarities(a,i)).getRawData();l[e]=1,s[e]=Array.from(l)}return{scoringMatrix:s,alphabetIndexes:o}}},8601:(t,e,s)=>{"use strict";s.d(e,{i0:()=>m});var i=s(4469),n=s(976),o=s(6414),r=s.n(o),a=s(1821),l=s(499);const h={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M RGP",V2K_A_LINE:"A ",V3K_COUNTS_SHIFT:14,V3K_IDX_SHIFT:7,V3K_HEADER_FIRST_LINE:"\nDatagrok macromolecule handler\n\n",V3K_HEADER_SECOND_LINE:" 0 0 0 0 0 0 999 V3000\n",V3K_BEGIN_CTAB_BLOCK:"M V30 BEGIN CTAB\n",V3K_END_CTAB_BLOCK:"M V30 END CTAB\n",V3K_BEGIN_COUNTS_LINE:"M V30 COUNTS ",V3K_COUNTS_LINE_ENDING:" 0 0 0\n",V3K_BEGIN_ATOM_BLOCK:"M V30 BEGIN ATOM\n",V3K_END_ATOM_BLOCK:"M V30 END ATOM\n",V3K_BEGIN_BOND_BLOCK:"M V30 BEGIN BOND\n",V3K_END_BOND_BLOCK:"M V30 END BOND\n",V3K_BOND_CONFIG:" CFG:",V3K_BEGIN_DATA_LINE:"M V30 ",V3K_END:"M END",PRECISION_FACTOR:1e4,DEOXYRIBOSE:"d",RIBOSE:"r",PHOSPHATE:"p",OXYGEN:"O",HYDROGEN:"H"};var c=s(1047);function u(t){return Math.round(h.PRECISION_FACTOR*t)/h.PRECISION_FACTOR}async function m(t,e,o){if(0===n.Func.find({package:"Chem",name:"getRdKitModule"}).length)return{col:null,warnings:['Transformation to atomic level requires the package "Chem" installed.']};if(e.semType!==n.SEMTYPE.MACROMOLECULE)return{col:null,warnings:[`Only the ${n.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let u=e;const m=l.Cn.getOrCreate(e);m.isHelm()&&(u=m.convert(a.r2.SEPARATOR,"."),u.name=e.name);const g=l.Cn.getOrCreate(u).alphabet;let p;if("PT"===g||"UN"===g)p="PEPTIDE";else{if("RNA"!==g&&"DNA"!==g)return{col:null,warnings:[`Unexpected column's '${u.name}' alphabet '${g}'.`]};p="RNA"}const f=function(t){const e=t.length,s=new Array(e),i=l.Cn.getOrCreate(t).getSplitter();for(let n=0;n<e;++n){const e=t.get(n);s[n]=e?r()(i(e)).filter((t=>""!==t)).toArray():[]}return s}(u),y=await async function(t,e,s,n){const o=function(t,e,s){const i=new Map;for(const n of t.getMonomerSymbolsByType(e)){const o=t.getMonomer(e,n);if("RNA"===e&&("Branch"===o.monomerType||"DNA"===s&&o.symbol===h.DEOXYRIBOSE||"RNA"===s&&o.symbol===h.RIBOSE||o.symbol===h.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==o.monomerType){const t={};c.rx.forEach((e=>{t[e]=o[e]})),i.set(o.symbol,t)}}return i}(e,s,n),r=new Map,a=await i.functions.call("Chem:getRdKitModule"),l={value:null};if("RNA"===s){const t="RNA"===n?[h.RIBOSE,h.PHOSPHATE]:[h.DEOXYRIBOSE,h.PHOSPHATE];for(const e of t)d(r,e,o,a,s,l)}for(let e=0;e<t.length;++e){const i=t[e];for(const t of i)if(""!==t)try{d(r,t,o,a,s,l)}catch(e){const s=e instanceof Error?e.message:e.toString(),i=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n${s}\n${i}`),new Error(`Can't get monomer '${t}' from library: ${s}`)}}return r}(f,o,p,g),b=u.length,{molfileList:w,molfileWarningList:C}=await async function(t,e,i,n,o){const r=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(r).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=o/r;let h=[],c=[];const u=new Array(r);for(let s=0;s<r;s++){const h=Math.floor(s*l),c=s===r-1?o:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:i,polymerType:n,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(f,y,g,p,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const v=`molfile(${u.name})`,S=t.columns.getUnusedName(v),T=n.Column.fromStrings(S,w);return T.semType=n.SEMTYPE.MOLECULE,T.setTag(n.TAGS.UNITS,n.UNITS.Molecule.MOLBLOCK),{col:T,warnings:C}}function d(t,e,s,i,n,o){if(!t.has(e)){const r=function(t,e,s,i,n){if(e.has(t)){const o=e.get(t),r=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(o.rgroups),a=function(t){const e=new Map;let s=t.indexOf(h.V2K_A_LINE,0),i=s;for(;-1!==s;){i=t.indexOf("\n",s);const n=parseInt(t.substring(s,i).replace(/^A\s+/,""));s=t.indexOf("R",i),i=t.indexOf("\n",s);const o=parseInt(t.substring(s,i).replace(/^R/,""));e.set(n,o),s=t.indexOf(h.V2K_A_LINE,i)}for(s=t.indexOf(h.V2K_RGP_LINE,0),i=t.indexOf("\n",s);-1!==s;){s+=h.V2K_RGP_SHIFT,i=t.indexOf("\n",s);const n=t.substring(s,i).replaceAll(/\s+/g," ").split(" ").map((t=>parseInt(t))).slice(1);for(let t=0;t<n.length;t+=2){if(e.has(n[t])&&e.get(n[t])!==n[t+1])throw new Error(`r-group index ${n[t]} has already been added with a different value`);e.set(n[t],n[t+1])}s=t.indexOf(h.V2K_RGP_LINE,i)}return e}(o.molfile),l=function(t,e){const s=e.get_mol(t),i=s.get_v3Kmolblock();return s.delete(),i}(function(t){let e=t.indexOf(h.V2K_A_LINE,0);-1===e&&(e=t.indexOf(h.V2K_RGP_LINE));const s=t.indexOf(h.V3K_END,e);return t.substring(0,e)+t.substring(s)}(o.molfile),s),c=function(t){let e=(t=t.replaceAll("\r","")).indexOf(h.V3K_BEGIN_COUNTS_LINE)+h.V3K_COUNTS_SHIFT,s=t.indexOf(" ",e+1);const i=parseInt(t.substring(e,s));return e=s+1,s=t.indexOf(" ",e+1),{atomCount:i,bondCount:parseInt(t.substring(e,s))}}(l),m=function(t,e){const s=new Array(e),i=new Float32Array(e),n=new Float32Array(e),o=new Array(e);let r=t.indexOf(h.V3K_BEGIN_ATOM_BLOCK);r=t.indexOf("\n",r);let a=r;for(let l=0;l<e;l++){r=t.indexOf(h.V3K_BEGIN_DATA_LINE,r)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",r),r=a+1,a=t.indexOf(" ",r),s[l]=t.substring(r,a);const e=new Array(2);for(let s=0;s<2;++s)r=a+1,a=t.indexOf(" ",r),e[s]=parseFloat(t.substring(r,a));i[l]=e[0],n[l]=e[1],r=a,a=t.indexOf("\n",r)+1,o[l]=t.slice(r,a),r=a}return{atomTypes:s,x:i,y:n,kwargs:o}}(l,c.atomCount),d=function(t,e){const s=new Uint32Array(e),i=new Array(e),n=new Map,o=new Map;let r=t.indexOf(h.V3K_BEGIN_BOND_BLOCK);r=t.indexOf("\n",r);let a=r;for(let l=0;l<e;++l){const e=new Array(3);r=t.indexOf(h.V3K_BEGIN_DATA_LINE,a)+h.V3K_IDX_SHIFT,a=t.indexOf(" ",r);for(let s=0;s<3;++s)r=a+1,a=Math.min(t.indexOf("\n",r),t.indexOf(" ",r)),e[s]=parseInt(t.slice(r,a));s[l]=e[0],i[l]=e.slice(1);const c=t.indexOf("\n",r);let u=t.slice(a,c),m=u.indexOf(h.V3K_BOND_CONFIG);if(-1!==m){m=u.indexOf("=",m)+1;let t=u.indexOf(" ",m);-1===t&&(t=u.length);const e=parseInt(u.slice(m,t));n.set(l,e);const s=h.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||o.set(l,u)}return{bondTypes:s,atomPairs:i,bondConfiguration:n,kwargs:o}}(l,c.bondCount),y={atoms:m,bonds:d,meta:g(m,d,r,a)};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;T(t,-i[e],-n[e]);const o=C(i[s],n[s]);v(t.atoms,-o),i[t.meta.rNodes[1]-1]<0&&function(t){S(t,!1)}(t);const r=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=s[t],n=s[(t+1)%2];e.has(i)?e.get(i)?.push(n):e.set(i,new Array(1).fill(n))}return e}(t);let s=0,i=0;for(;0===s;){const n=e.get(t.meta.terminalNodes[1])[i];t.atoms.atomTypes[n-1]===h.OXYGEN&&n!==t.meta.rNodes[1]&&(s=n),i++}return s}(t);!function(t,e){t.atoms.y[t.meta.rNodes[1]-1]<0&&t.atoms.y[e-1]<0&&(function(t){S(t,!0)}(t),v(t.atoms,-function(t,e){return C(t,e)+Math.PI/2}(t.atoms.x[t.meta.terminalNodes[1]-1],t.atoms.y[t.meta.terminalNodes[1]-1])))}(t,r),function(t,e){const s=t.atoms.x;s[t.meta.rNodes[1]-1]>s[e-1]&&function(t,e,s){const i=e-1,n=s-1,o=t.atoms.x,r=t.atoms.y,a=o[i],l=r[i];o[i]=o[n],r[i]=r[n],o[n]=a,r[n]=l}(t,e,t.meta.rNodes[1])}(t,r)}(y):t===h.RIBOSE||t===h.DEOXYRIBOSE?function(t,e){const s=t.atoms.x,i=t.atoms.y;let n=t.meta.terminalNodes[0]-1;const o=t.meta.rNodes[1]-1;T(t,-s[n],-i[n]);const r=C(s[o],i[o]);v(t.atoms,3*Math.PI/2-r),e.value=function(t){const e=t.atoms.x,s=t.atoms.y,i=t.meta.rNodes[2]-1,n=t.meta.terminalNodes[2]-1,o=e[i]-e[n],r=s[i]-s[n];return Math.atan(r/o)+Math.PI/2}(t),n=t.meta.terminalNodes[0]-1,T(t,-s[n],-i[n])}(y,n):t===h.PHOSPHATE?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;T(t,-i[e],-n[e]);const 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g(t){return o()(t.toString().matchAll(a.BM)).map((t=>t[2]??t[1])).toArray()}function p(t){return t||[]}function f(t,e=undefined){return s=>s?s.split(t,e):[]}const y=/(PEPTIDE1|DNA1|RNA1)\{([^}]+)}/g,b=/\[([^\[\]]+)]/g;function w(t){y.lastIndex=0;const e=y.exec(t.toString()),s=e?e[2]:null;return(s?s.split("."):[]).map((t=>{b.lastIndex=0;const e=b.exec(t);return e&&e.length>=2?e[1]:t}))}function C(t,e,s=undefined){if(t.toLowerCase().startsWith(a.r2.FASTA))return g;if(t.toLowerCase().startsWith(a.r2.SEPARATOR))return f(e,s);if(t.toLowerCase().startsWith(a.r2.HELM))return w;throw new Error(`Unexpected units ${t} .`)}function v(t){return l.Cn.getOrCreate(t).getSplitter()}const S=/([^\W_]+)/g;function T(t,e){if(t.length<=e)return t;const s=t.match(S),i=t.length>e||(s?.length??0)>1,n=s?.[0]??" 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m.J.Chromatogram;default:return d.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var i=s(976),n=s(6414),o=s.n(n),r=s(585);function a(t){const e=(0,r.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return n.push(e),e},n=[],a=t.length,l=i.DataFrame.create(a);for(let i=0;i<a;++i){const r=t.get(i);if(null==r)continue;const a=e(r);for(const[t,e]of o().enumerate(a))((n[e]??null)||s(e)).set(i,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>d});var i=s(976),n=s(6414),o=s.n(n),r=s(8447),a=s(585),l=s(489),h=s(7228),c=s(1047);const u=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}},m={[r.r2.FASTA]:"-",[r.r2.SEPARATOR]:"",[r.r2.HELM]:"*"};class d{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==r.r2.FASTA)throw new Error(`The column of notation '${r.r2.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,r.r2.FASTA),d.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==r.r2.SEPARATOR)throw new Error(`The column of notation '${r.r2.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${r.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(i.TAGS.UNITS,r.r2.SEPARATOR),t.column.setTag("separator",e),d.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${r.r2.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,r.r2.HELM),d.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[r.r2.FASTA,r.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");let e=t.column.getTag("aligned");null===e&&(e=s.sameLength?"SEQ.MSA":"SEQ",t.column.setTag("aligned",e));let i=t.column.getTag("alphabet");if(null===i&&(i=(0,a.w4)(s.freq,r.XS),t.column.setTag("alphabet",i)),"UN"===i){const e=Object.keys(s.freq).length,i=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===r.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==r.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===r.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),i=this._column.categories;for(let n=0;n<e;n++){const e=i[s[n]];this._splitted[n]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const i of this.splitted){null==s?s=i.length:i.length!==s&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=Math.max(...this.splitted.map((t=>t.length)))),this._maxLength}get posList(){if(null===this._posList){const t=this.column.getTag(".positionNames");this._posList=t?t.split(r.CI).map((t=>t.trim())):o().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===r.r2.FASTA}isSeparator(){return this.notation===r.r2.SEPARATOR}isHelm(){return this.notation===r.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===r.r2.FASTA&&t===m[r.r2.FASTA]||this.units===r.r2.HELM&&t===m[r.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(r.r2.FASTA))return r.r2.FASTA;if(this.units.toLowerCase().startsWith(r.r2.SEPARATOR))return r.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(r.r2.HELM))return r.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e){const s=this.column,n=s.length,o=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(o),l=i.Column.fromList("string",a,new Array(n).fill(""));if(l.semType=i.SEMTYPE.MACROMOLECULE,l.setTag(i.TAGS.UNITS,t),t===r.r2.SEPARATOR){if(!e)throw new Error(`Notation '${r.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==r.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=d.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[r.r2.FASTA,r.r2.SEPARATOR,r.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!d.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const n=i.Column.fromList("string",e,new Array(t).fill(""));return n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,s),n}getSplitter(t){if(this.units.toLowerCase().startsWith(r.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?a.kB:a.FJ;if(this.units.toLowerCase().startsWith(r.r2.SEPARATOR))return(0,a.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(r.r2.HELM))return a.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");return this.isMsa()?l.U.HAMMING:(this.alphabet,l.U.LEVENSHTEIN)}getDistanceFunction(){return l.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,h.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,a.Ar)(this.separator);for(const t of this.column.categories){const i=s(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===r.r2.FASTA}toSeparator(t){return t===r.r2.SEPARATOR}toHelm(t){return t===r.r2.HELM}convertHelmToFastaSeparator(t,e,s,i){i||(i=this.toFasta(e)?m[r.r2.FASTA]:m[r.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const n=t.startsWith("RNA"),o=this.splitter(t),a=[];for(let t=0;t<o.length;t++){let s=o[t];if(n&&(s=s.replace(c.pU,"")),s===m[r.r2.HELM])a.push(i);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";a.push(t)}else a.push(s)}return a.join(s)}convert(t,e){const s=this.getConverter(t,e),i=this.getNewColumn(t,e);return i.init((t=>s(this.column.get(t)))),i}getRegion(t,e,s){const i=this.getNewColumn(this.notation,this.separator);i.name=s,Math.max(...this.splitted.map((t=>t.length)));const n=t??0,o=e??this.maxLength-1,a=this.getJoiner(),l=o-n+1;i.init((t=>{const e=this.splitted[t],s=new Array(l);for(let t=0;t<l;++t){const i=n+t;s[t]=i<e.length?e[i]:m[this.notation]}return a(s)}));const h=t=>{const e=t.split(",").map((t=>t.trim())),s=new Array(l);for(let t=0;t<l;++t){const i=n+t;s[t]=i<e.length?e[i]:"?"}return s.join(r.CI)},c=this.column.getTag(".positionNames");c&&i.setTag(".positionNames",h(c));const u=this.column.getTag(".positionLabels");return u&&i.setTag(".positionLabels",h(u)),i}getJoiner(){const t=this;if(this.notation===r.r2.FASTA)return function(e){return g(t,e)};if(this.notation===r.r2.SEPARATOR)return function(e){return p(t,e,t.separator)};if(this.notation===r.r2.HELM){const e="DNA"===t.alphabet||"RNA"===t.alphabet;return function(s){return f(t,s,e)}}throw new Error}getConverter(t,e=undefined){if(t===r.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${r.r2.SEPARATOR}'.`);const s=this;if(t===r.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?y(t,e):t.getSplitter()(e);return g(t,s)}(s,t)};if(t===r.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA")||e.startsWith("RNA"),i=t.getSplitter()(e);return f(t,i,s)}(s,t)};if(t===r.r2.SEPARATOR)return function(t){return function(t,e,s){const i=t.isHelm()?y(t,e):t.getSplitter()(e);return p(t,i,s)}(s,t,e)};throw new Error}constructor(t){if(this._splitter=null,this._splitted=null,this._stats=null,this._maxLength=null,this._posList=null,t.type!=i.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${i.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?m[r.r2.FASTA]:this.isHelm()?m[r.r2.HELM]:m[r.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())d.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");d.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);d.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return u.uhTemp in t.temp||(t.temp[u.uhTemp]=new d(t)),t.temp[u.uhTemp]}}function g(t,e){const s=new Array(e.length);for(const[i,n]of o().enumerate(e)){let o=i;t.isHelm()&&(o=i.replace(c.pU,"$1")),t.isGap(o)?o=m[r.r2.FASTA]:o.length>1&&(o="["+e[n]+"]"),s[n]=o}return s.join("")}function p(t,e,s){const i=new Array(e.length);for(const[s,n]of o().enumerate(e)){let e=s;t.isGap(e)&&(e=m[r.r2.SEPARATOR]),i[n]=e}return i.map((t=>t??"")).join(s)}function f(t,e,s){const[i,n,a,l]=t.getHelmWrappers();return`${i}${o()(e).map((e=>{let i=e;return i=t.isGap(i)?m[r.r2.HELM]:s?i.replace(c.pU,"$1"):1==e.length?`${n}${e}${a}`:`${n}[${e}]${a}`,i})).toArray().join(".")}${l}`}function y(t,e){const s=t.getSplitter()(e),i=new Array(s.length),n=e.startsWith("DNA"),r=e.startsWith("RNA");for(const[t,e]of o().enumerate(s)){let s=t;(n||r)&&(s=s.replace(c.pU,"$1"),s=s===c.$3?null:s),i[e]=s}return i.filter((t=>null!==t))}},9298:(t,e,s)=>{"use strict";var i,n,o,r,a,l;s.d(e,{Ct:()=>l,DX:()=>i,ES:()=>n,dE:()=>a,iD:()=>r,vS:()=>h,vw:()=>o}),function(t){t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(o||(o={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(r||(r={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=n.Entropy,this.positionWidth=16,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=r.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>i});class i{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(868),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0,i){return new Promise((async(n,o)=>{try{const o=t.length,r=new Array(this._workerCount),a=o*(o-1)/2;this._workerCount=Math.min(this._workerCount,a);const l=a/this._workerCount,h=new 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a=t[n][o];i[n][r]+=e[n][o]*s[a][r]}return i}(a.HU(C.indices,v,this.nNeighbors),a.HU(C.values,v,this.nNeighbors),this.embedding),T=this.nEpochs?this.nEpochs/3:b.nRows<=1e4?100:30,M=b.getValues().reduce(((t,e)=>e>t?e:t),0);b=b.map((t=>t<M/T?0:t)),b=n.RH(b);const A=this.makeEpochsPerSample(b.getValues(),T),E=b.getRows(),x=b.getCols();return this.assignOptimizationStateParameters({headEmbedding:S,tailEmbedding:this.embedding,head:E,tail:x,currentEpoch:0,nEpochs:T,nVertices:b.getDims()[1],epochsPerSample:A}),this.prepareForOptimizationLoop(),this.optimizeLayout()}processGraphForSupervisedProjection(){const{Y:t,X:e}=this;if(t){if(t.length!==e.length)throw new Error("Length of X and y must be equal");if("categorical"===this.targetMetric){const e=this.targetWeight<1?1/(1-this.targetWeight)*2.5:1e12;this.graph=this.categoricalSimplicialSetIntersection(this.graph,t,e)}}}step(){const{currentEpoch:t}=this.optimizationState;return t<this.getNEpochs()&&this.optimizeLayoutStep(t),this.optimizationState.currentEpoch}getEmbedding(){return this.embedding}nearestNeighbors(t){const{distanceFn:e,nNeighbors:s}=this,i=o.WX(e,this.random),n=5+Math.floor(.5==(a=t.length**.5/20)?0:Math.round(a));var a;const l=Math.max(5,Math.floor(Math.round((t=>Math.log(t)/Math.log(2))(t.length))));this.rpForest=r.Zv(t,s,n,this.random);const h=r.HO(this.rpForest),{indices:c,weights:u}=i(t,h,s,l);return{knnIndices:c,knnDistances:u}}fuzzySimplicialSet(t,e,s=1){const{knnIndices:i=[],knnDistances:o=[],localConnectivity:r}=this,{sigmas:a,rhos:l}=this.smoothKNNDistance(o,e,r),{rows:h,cols:c,vals:u}=this.computeMembershipStrengths(i,o,a,l),m=[t.length,t.length],d=new n.A7(h,c,u,m),g=n.p4(d),p=n.NT(d,g),f=n.$X(n.IH(d,g),p),y=n.cf(f,s),b=n.cf(p,1-s);return n.IH(y,b)}categoricalSimplicialSetIntersection(t,e,s,i=1){let o=function(t,e,s=1,i=5){return t.map(((t,n,o)=>-1===e[n]||-1===e[o]?t*Math.exp(-s):e[n]!==e[o]?t*Math.exp(-i):t))}(t,e,i,s);return o=n.RH(o),function(t){t=n.Fv(t,"max");const e=n.p4(t),s=n.NT(e,t);return t=n.IH(t,n.$X(e,s)),n.RH(t)}(o)}smoothKNNDistance(t,e,s=1,i=64,n=1){const o=Math.log(e)/Math.log(2)*n,r=a.ll(t.length),l=a.ll(t.length);for(let e=0;e<t.length;e++){let n=0,u=1/0,m=1;const d=t[e],g=d.filter((t=>t>0));if(g.length>=s){let t=Math.floor(s),i=s-t;t>0?(r[e]=g[t-1],i>h&&(r[e]+=i*(g[t]-g[t-1]))):r[e]=i*g[0]}else g.length>0&&(r[e]=a.Fp(g));for(let s=0;s<i;s++){let s=0;for(let i=1;i<t[e].length;i++){const n=t[e][i]-r[e];s+=n>0?Math.exp(-n/m):1}if(Math.abs(s-o)<h)break;s>o?(u=m,m=(n+u)/2):(n=m,u===1/0?m*=2:m=(n+u)/2)}if(l[e]=m,r[e]>0){const t=a.J6(d);l[e]<c*t&&(l[e]=c*t)}else{const s=a.J6(t.map(a.J6));l[e]<c*s&&(l[e]=c*s)}}return{sigmas:l,rhos:r}}computeMembershipStrengths(t,e,s,i){const n=t.length,o=t[0].length,r=a.ll(n*o),l=a.ll(n*o),h=a.ll(n*o);for(let a=0;a<n;a++)for(let n=0;n<o;n++){let c=0;-1!==t[a][n]&&(c=t[a][n]===a?0:e[a][n]-i[a]<=0?1:Math.exp(-(e[a][n]-i[a])/s[a]),r[a*o+n]=a,l[a*o+n]=t[a][n],h[a*o+n]=c)}return{rows:r,cols:l,vals:h}}initializeSimplicialSetEmbedding(){const t=this.getNEpochs(),{nComponents:e}=this,s=this.graph.getValues();let i=0;for(let t=0;t<s.length;t++){const e=s[t];i<s[t]&&(i=e)}const n=this.graph.map((e=>e<i/t?0:e));this.embedding=a.ll(n.nRows).map((()=>a.ll(e).map((()=>20*a.mH(this.random)-10))));const o=[],r=[],l=[],h=n.getAll();for(let t=0;t<h.length;t++){const e=h[t];e.value&&(o.push(e.value),l.push(e.row),r.push(e.col))}return{head:r,tail:l,epochsPerSample:this.makeEpochsPerSample(o,t)}}makeEpochsPerSample(t,e){const s=a.VI(t.length,-1),i=a.Fp(t),n=t.map((t=>t/i*e));return n.forEach(((t,i)=>{t>0&&(s[i]=e/n[i])})),s}assignOptimizationStateParameters(t){Object.assign(this.optimizationState,t)}prepareForOptimizationLoop(){const{repulsionStrength:t,learningRate:e,negativeSampleRate:s}=this,{epochsPerSample:i,headEmbedding:n,tailEmbedding:o}=this.optimizationState,r=n[0].length,a=n.length===o.length,l=i.map((t=>t/s)),h=[...l],c=[...i];this.assignOptimizationStateParameters({epochOfNextSample:c,epochOfNextNegativeSample:h,epochsPerNegativeSample:l,moveOther:a,initialAlpha:e,alpha:e,gamma:t,dim:r})}initializeOptimization(){const t=this.embedding,e=this.embedding,{head:s,tail:i,epochsPerSample:n}=this.optimizationState,o=this.getNEpochs(),r=this.graph.nCols,{a:h,b:c}=function(t,e){const s=a.GE(0,3*t,300).map((t=>t<e?1:t)),i=a.ll(s.length).map(((i,n)=>s[n]>=e?Math.exp(-(s[n]-e)/t):i)),n={x:s,y:i},{parameterValues:o}=(0,l.Z)(n,(([t,e])=>s=>1/(1+t*s**(2*e))),{damping:1.5,initialValues:[.5,.5],gradientDifference:.1,maxIterations:100,errorTolerance:.01}),[r,h]=o;return{a:r,b:h}}(this.spread,this.minDist);this.assignOptimizationStateParameters({headEmbedding:t,tailEmbedding:e,head:s,tail:i,epochsPerSample:n,a:h,b:c,nEpochs:o,nVertices:r})}optimizeLayoutStep(t){const{optimizationState:e}=this,{head:s,tail:i,headEmbedding:n,tailEmbedding:o,epochsPerSample:r,epochOfNextSample:l,epochOfNextNegativeSample:h,epochsPerNegativeSample:c,moveOther:u,initialAlpha:m,alpha:d,gamma:f,a:y,b,dim:w,nEpochs:C,nVertices:v}=e;for(let e=0;e<r.length;e++){if(l[e]>t)continue;const m=s[e],C=i[e],S=n[m],T=o[C],M=p(S,T);let A=0;M>0&&(A=-2*y*b*Math.pow(M,b-1),A/=y*Math.pow(M,b)+1);for(let t=0;t<w;t++){const e=g(A*(S[t]-T[t]),4);S[t]+=e*d,u&&(T[t]+=-e*d)}l[e]+=r[e];const 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Cannot rescale a constant array");var l=s.min,h=void 0===l?s.autoMinMax?r:0:l,c=s.max,u=void 0===c?s.autoMinMax?a:1:c;if(h>=u)throw new RangeError("min option must be smaller than max option");for(var m=(u-h)/(a-r),d=0;d<t.length;d++)e[d]=(t[d]-r)*m+h;return e}},6241:(t,e,s)=>{"use strict";s.d(e,{N:()=>n});const i=Object.prototype.toString;function n(t){return i.call(t).endsWith("Array]")}},1353:(t,e,s)=>{"use strict";function i(t,e,s){let i=0;const n=s(e);for(let e=0;e<t.x.length;e++)i+=Math.abs(t.y[e]-n(t.x[e]));return i}s.d(e,{Z:()=>i})},3107:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(7531),n=s(1353),o=s(8188);function r(t,e,s={}){let{maxIterations:r=100,gradientDifference:a=.1,damping:l=0,errorTolerance:h=.01,minValues:c,maxValues:u,initialValues:m}=s;if(l<=0)throw new Error("The damping option must be a positive number");if(!t.x||!t.y)throw new Error("The data parameter must have x and y elements");if(!(0,i.Z)(t.x)||t.x.length<2||!(0,i.Z)(t.y)||t.y.length<2)throw new Error("The data parameter elements must be an array with more than 2 points");if(t.x.length!==t.y.length)throw new Error("The data parameter elements must have the same size");let d=m||new Array(e.length).fill(1),g=d.length;if(u=u||new Array(g).fill(Number.MAX_SAFE_INTEGER),c=c||new Array(g).fill(Number.MIN_SAFE_INTEGER),u.length!==c.length)throw new Error("minValues and maxValues must be the same size");if(!(0,i.Z)(d))throw new Error("initialValues must be an array");let p,f=(0,n.Z)(t,d,e),y=f<=h;for(p=0;p<r&&!y;p++){d=(0,o.Z)(t,d,l,a,e);for(let t=0;t<g;t++)d[t]=Math.min(Math.max(c[t],d[t]),u[t]);if(f=(0,n.Z)(t,d,e),isNaN(f))break;y=f<=h}return{parameterValues:d,parameterError:f,iterations:p}}},8188:(t,e,s)=>{"use strict";s.d(e,{Z:()=>o});var i=s(1174),n=s(8345);function o(t,e,s,o,r){let a=s*o*o,l=i.Z.eye(e.length,e.length,a);const h=r(e);let c=new Float64Array(t.x.length);for(let e=0;e<t.x.length;e++)c[e]=h(t.x[e]);let u=function(t,e,s,n,o){const r=s.length,a=t.x.length;let l=new Array(r);for(let i=0;i<r;i++){l[i]=new Array(a);let r=s.slice();r[i]+=n;let h=o(r);for(let s=0;s<a;s++)l[i][s]=e[s]-h(t.x[s])}return new i.Z(l)}(t,c,e,o,r),m=function(t,e){const s=t.x.length;let n=new Array(s);for(let i=0;i<s;i++)n[i]=[t.y[i]-e[i]];return new i.Z(n)}(t,c),d=(0,n.S)(l.add(u.mmul(u.transpose())));return(e=(e=new i.Z([e])).sub(d.mmul(u).mmul(m).mul(o).transpose())).to1DArray()}},5776:(t,e,s)=>{"use strict";s.d(e,{N:()=>n});const i=Object.prototype.toString;function n(t){return i.call(t).endsWith("Array]")}},2313:(t,e,s)=>{"use strict";s.d(e,{Z:()=>o});var i=s(1174),n=s(8353);class o{constructor(t){let e,s,i,o,r,a,l,h,c,u=(t=n.Z.checkMatrix(t)).clone(),m=u.rows,d=u.columns,g=new Float64Array(m),p=1;for(e=0;e<m;e++)g[e]=e;for(h=new Float64Array(m),s=0;s<d;s++){for(e=0;e<m;e++)h[e]=u.get(e,s);for(e=0;e<m;e++){for(c=Math.min(e,s),r=0,i=0;i<c;i++)r+=u.get(e,i)*h[i];h[e]-=r,u.set(e,s,h[e])}for(o=s,e=s+1;e<m;e++)Math.abs(h[e])>Math.abs(h[o])&&(o=e);if(o!==s){for(i=0;i<d;i++)a=u.get(o,i),u.set(o,i,u.get(s,i)),u.set(s,i,a);l=g[o],g[o]=g[s],g[s]=l,p=-p}if(s<m&&0!==u.get(s,s))for(e=s+1;e<m;e++)u.set(e,s,u.get(e,s)/u.get(s,s))}this.LU=u,this.pivotVector=g,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=i.Z.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,o,r=t.columns,a=t.subMatrixRow(this.pivotVector,0,r-1),l=e.columns;for(o=0;o<l;o++)for(s=o+1;s<l;s++)for(n=0;n<r;n++)a.set(s,n,a.get(s,n)-a.get(o,n)*e.get(s,o));for(o=l-1;o>=0;o--){for(n=0;n<r;n++)a.set(o,n,a.get(o,n)/e.get(o,o));for(s=0;s<o;s++)for(n=0;n<r;n++)a.set(s,n,a.get(s,n)-a.get(o,n)*e.get(s,o))}return a}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let i=0;i<s;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new i.Z(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new i.Z(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}},7072:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(1174),n=s(8353),o=s(6310);class r{constructor(t){let e,s,i,r,a=(t=n.Z.checkMatrix(t)).clone(),l=t.rows,h=t.columns,c=new Float64Array(h);for(i=0;i<h;i++){let t=0;for(e=i;e<l;e++)t=(0,o.G)(t,a.get(e,i));if(0!==t){for(a.get(i,i)<0&&(t=-t),e=i;e<l;e++)a.set(e,i,a.get(e,i)/t);for(a.set(i,i,a.get(i,i)+1),s=i+1;s<h;s++){for(r=0,e=i;e<l;e++)r+=a.get(e,i)*a.get(e,s);for(r=-r/a.get(i,i),e=i;e<l;e++)a.set(e,s,a.get(e,s)+r*a.get(e,i))}}c[i]=-t}this.QR=a,this.Rdiag=c}solve(t){t=i.Z.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,o,r,a,l=t.columns,h=t.clone(),c=e.columns;for(r=0;r<c;r++)for(o=0;o<l;o++){for(a=0,n=r;n<s;n++)a+=e.get(n,r)*h.get(n,o);for(a=-a/e.get(r,r),n=r;n<s;n++)h.set(n,o,h.get(n,o)+a*e.get(n,r))}for(r=c-1;r>=0;r--){for(o=0;o<l;o++)h.set(r,o,h.get(r,o)/this.Rdiag[r]);for(n=0;n<r;n++)for(o=0;o<l;o++)h.set(n,o,h.get(n,o)-h.get(r,o)*e.get(n,r))}return h.subMatrix(0,c-1,0,l-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,o=new i.Z(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?o.set(t,e,s.get(t,e)):t===e?o.set(t,e,this.Rdiag[t]):o.set(t,e,0);return o}get orthogonalMatrix(){let t,e,s,n,o=this.QR,r=o.rows,a=o.columns,l=new i.Z(r,a);for(s=a-1;s>=0;s--){for(t=0;t<r;t++)l.set(t,s,0);for(l.set(s,s,1),e=s;e<a;e++)if(0!==o.get(s,s)){for(n=0,t=s;t<r;t++)n+=o.get(t,s)*l.get(t,e);for(n=-n/o.get(s,s),t=s;t<r;t++)l.set(t,e,l.get(t,e)+n*o.get(t,s))}}return l}}},6943:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(1174),n=s(8353),o=s(6310);class r{constructor(t,e={}){if((t=n.Z.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,r=t.columns;const{computeLeftSingularVectors:a=!0,computeRightSingularVectors:l=!0,autoTranspose:h=!1}=e;let c,u=Boolean(a),m=Boolean(l),d=!1;if(s<r)if(h){c=t.transpose(),s=c.rows,r=c.columns,d=!0;let e=u;u=m,m=e}else c=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else c=t.clone();let g=Math.min(s,r),p=Math.min(s+1,r),f=new Float64Array(p),y=new i.Z(s,g),b=new i.Z(r,r),w=new Float64Array(r),C=new Float64Array(s),v=new Float64Array(p);for(let t=0;t<p;t++)v[t]=t;let S=Math.min(s-1,r),T=Math.max(0,Math.min(r-2,s)),M=Math.max(S,T);for(let t=0;t<M;t++){if(t<S){f[t]=0;for(let e=t;e<s;e++)f[t]=(0,o.G)(f[t],c.get(e,t));if(0!==f[t]){c.get(t,t)<0&&(f[t]=-f[t]);for(let e=t;e<s;e++)c.set(e,t,c.get(e,t)/f[t]);c.set(t,t,c.get(t,t)+1)}f[t]=-f[t]}for(let e=t+1;e<r;e++){if(t<S&&0!==f[t]){let i=0;for(let n=t;n<s;n++)i+=c.get(n,t)*c.get(n,e);i=-i/c.get(t,t);for(let n=t;n<s;n++)c.set(n,e,c.get(n,e)+i*c.get(n,t))}w[e]=c.get(t,e)}if(u&&t<S)for(let e=t;e<s;e++)y.set(e,t,c.get(e,t));if(t<T){w[t]=0;for(let e=t+1;e<r;e++)w[t]=(0,o.G)(w[t],w[e]);if(0!==w[t]){w[t+1]<0&&(w[t]=0-w[t]);for(let e=t+1;e<r;e++)w[e]/=w[t];w[t+1]+=1}if(w[t]=-w[t],t+1<s&&0!==w[t]){for(let e=t+1;e<s;e++)C[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<r;s++)C[e]+=w[s]*c.get(e,s);for(let e=t+1;e<r;e++){let i=-w[e]/w[t+1];for(let n=t+1;n<s;n++)c.set(n,e,c.get(n,e)+i*C[n])}}if(m)for(let e=t+1;e<r;e++)b.set(e,t,w[e])}}let A=Math.min(r,s+1);if(S<r&&(f[S]=c.get(S,S)),s<A&&(f[A-1]=0),T+1<A&&(w[T]=c.get(T,A-1)),w[A-1]=0,u){for(let t=S;t<g;t++){for(let e=0;e<s;e++)y.set(e,t,0);y.set(t,t,1)}for(let t=S-1;t>=0;t--)if(0!==f[t]){for(let e=t+1;e<g;e++){let i=0;for(let n=t;n<s;n++)i+=y.get(n,t)*y.get(n,e);i=-i/y.get(t,t);for(let n=t;n<s;n++)y.set(n,e,y.get(n,e)+i*y.get(n,t))}for(let e=t;e<s;e++)y.set(e,t,-y.get(e,t));y.set(t,t,1+y.get(t,t));for(let e=0;e<t-1;e++)y.set(e,t,0)}else{for(let e=0;e<s;e++)y.set(e,t,0);y.set(t,t,1)}}if(m)for(let t=r-1;t>=0;t--){if(t<T&&0!==w[t])for(let e=t+1;e<r;e++){let s=0;for(let i=t+1;i<r;i++)s+=b.get(i,t)*b.get(i,e);s=-s/b.get(t+1,t);for(let i=t+1;i<r;i++)b.set(i,e,b.get(i,e)+s*b.get(i,t))}for(let e=0;e<r;e++)b.set(e,t,0);b.set(t,t,1)}let E=A-1,x=0,I=Number.EPSILON;for(;A>0;){let t,e;for(t=A-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+I*Math.abs(f[t]+Math.abs(f[t+1]));if(Math.abs(w[t])<=e||Number.isNaN(w[t])){w[t]=0;break}}if(t===A-2)e=4;else{let s;for(s=A-1;s>=t&&s!==t;s--){let e=(s!==A?Math.abs(w[s]):0)+(s!==t+1?Math.abs(w[s-1]):0);if(Math.abs(f[s])<=I*e){f[s]=0;break}}s===t?e=3:s===A-1?e=1:(e=2,t=s)}switch(t++,e){case 1:{let e=w[A-2];w[A-2]=0;for(let s=A-2;s>=t;s--){let i=(0,o.G)(f[s],e),n=f[s]/i,a=e/i;if(f[s]=i,s!==t&&(e=-a*w[s-1],w[s-1]=n*w[s-1]),m)for(let t=0;t<r;t++)i=n*b.get(t,s)+a*b.get(t,A-1),b.set(t,A-1,-a*b.get(t,s)+n*b.get(t,A-1)),b.set(t,s,i)}break}case 2:{let e=w[t-1];w[t-1]=0;for(let i=t;i<A;i++){let n=(0,o.G)(f[i],e),r=f[i]/n,a=e/n;if(f[i]=n,e=-a*w[i],w[i]=r*w[i],u)for(let e=0;e<s;e++)n=r*y.get(e,i)+a*y.get(e,t-1),y.set(e,t-1,-a*y.get(e,i)+r*y.get(e,t-1)),y.set(e,i,n)}break}case 3:{const e=Math.max(Math.abs(f[A-1]),Math.abs(f[A-2]),Math.abs(w[A-2]),Math.abs(f[t]),Math.abs(w[t])),i=f[A-1]/e,n=f[A-2]/e,a=w[A-2]/e,l=f[t]/e,h=w[t]/e,c=((n+i)*(n-i)+a*a)/2,d=i*a*(i*a);let g=0;0===c&&0===d||(g=c<0?0-Math.sqrt(c*c+d):Math.sqrt(c*c+d),g=d/(c+g));let p=(l+i)*(l-i)+g,C=l*h;for(let e=t;e<A-1;e++){let i=(0,o.G)(p,C);0===i&&(i=Number.MIN_VALUE);let n=p/i,a=C/i;if(e!==t&&(w[e-1]=i),p=n*f[e]+a*w[e],w[e]=n*w[e]-a*f[e],C=a*f[e+1],f[e+1]=n*f[e+1],m)for(let t=0;t<r;t++)i=n*b.get(t,e)+a*b.get(t,e+1),b.set(t,e+1,-a*b.get(t,e)+n*b.get(t,e+1)),b.set(t,e,i);if(i=(0,o.G)(p,C),0===i&&(i=Number.MIN_VALUE),n=p/i,a=C/i,f[e]=i,p=n*w[e]+a*f[e+1],f[e+1]=-a*w[e]+n*f[e+1],C=a*w[e+1],w[e+1]=n*w[e+1],u&&e<s-1)for(let t=0;t<s;t++)i=n*y.get(t,e)+a*y.get(t,e+1),y.set(t,e+1,-a*y.get(t,e)+n*y.get(t,e+1)),y.set(t,e,i)}w[A-2]=p,x+=1;break}case 4:if(f[t]<=0&&(f[t]=f[t]<0?-f[t]:0,m))for(let e=0;e<=E;e++)b.set(e,t,-b.get(e,t));for(;t<E&&!(f[t]>=f[t+1]);){let e=f[t];if(f[t]=f[t+1],f[t+1]=e,m&&t<r-1)for(let 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o=0;o<s;o++)for(let s=0;s<i;s++)n.set(o,s,Math.max(t.get(o,s),e.get(o,s)));return n}static checkMatrix(t){return h.isMatrix(t)?t:new u(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.call(this,e,s);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.push(this.get(e,s));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let s=0;s<this.columns;s++)t[e].push(this.get(e,s))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 1===this.rows||1===this.columns}isSquare(){return this.rows===this.columns}isEmpty(){return 0===this.rows||0===this.columns}isSymmetric(){if(this.isSquare()){for(let t=0;t<this.rows;t++)for(let e=0;e<=t;e++)if(this.get(t,e)!==this.get(e,t))return!1;return!0}return!1}isEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);t++}return i}isReducedEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);for(let s=e+1;s<this.rows;s++)0!==this.get(t,s)&&(i=!1);t++}return i}echelonForm(){let t=this.clone(),e=0,s=0;for(;e<t.rows&&s<t.columns;){let i=e;for(let n=e;n<t.rows;n++)t.get(n,s)>t.get(i,s)&&(i=n);if(0===t.get(i,s))s++;else{t.swapRows(e,i);let n=t.get(e,s);for(let i=s;i<t.columns;i++)t.set(e,i,t.get(e,i)/n);for(let i=e+1;i<t.rows;i++){let n=t.get(i,s)/t.get(e,s);t.set(i,s,0);for(let o=s+1;o<t.columns;o++)t.set(i,o,t.get(i,o)-t.get(e,o)*n)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,i=s-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let n=0,o=!1;for(;n<s&&!1===o;)1===t.get(i,n)?o=!0:n++;for(let s=0;s<i;s++){let o=t.get(s,n);for(let r=n;r<e;r++){let e=t.get(s,r)-o*t.get(i,r);t.set(s,r,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let i=new u(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,t);return this}neg(){return this.mulS(-1)}getRow(t){(0,l.zb)(this,t);let e=[];for(let s=0;s<this.columns;s++)e.push(this.get(t,s));return e}getRowVector(t){return u.rowVector(this.getRow(t))}setRow(t,e){(0,l.zb)(this,t),e=(0,l.on)(this,e);for(let s=0;s<this.columns;s++)this.set(t,s,e[s]);return this}swapRows(t,e){(0,l.zb)(this,t),(0,l.zb)(this,e);for(let s=0;s<this.columns;s++){let i=this.get(t,s);this.set(t,s,this.get(e,s)),this.set(e,s,i)}return this}getColumn(t){(0,l.bp)(this,t);let e=[];for(let s=0;s<this.rows;s++)e.push(this.get(s,t));return e}getColumnVector(t){return u.columnVector(this.getColumn(t))}setColumn(t,e){(0,l.bp)(this,t),e=(0,l.Um)(this,e);for(let s=0;s<this.rows;s++)this.set(s,t,e[s]);return this}swapColumns(t,e){(0,l.bp)(this,t),(0,l.bp)(this,e);for(let s=0;s<this.rows;s++){let i=this.get(s,t);this.set(s,t,this.get(s,e)),this.set(s,e,i)}return this}addRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[s]);return this}subRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){(0,l.zb)(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){(0,l.bp)(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){(0,l.cT)(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)>t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){(0,l.cT)(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)<t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}maxRow(t){if((0,l.zb)(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){(0,l.zb)(this,t),(0,l.cT)(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),s[1]=i);return s}minRow(t){if((0,l.zb)(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){(0,l.zb)(this,t),(0,l.cT)(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),s[1]=i);return s}maxColumn(t){if((0,l.bp)(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){(0,l.bp)(this,t),(0,l.cT)(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),s[0]=i);return s}minColumn(t){if((0,l.bp)(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){(0,l.bp)(this,t),(0,l.cT)(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),s[0]=i);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){h.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let i=0;i<e.length;i++)s+=e[i]*t[i];return s}mmul(t){t=u.checkMatrix(t);let e=this.rows,s=this.columns,i=t.columns,n=new u(e,i),o=new Float64Array(s);for(let r=0;r<i;r++){for(let e=0;e<s;e++)o[e]=t.get(e,r);for(let t=0;t<e;t++){let e=0;for(let i=0;i<s;i++)e+=this.get(t,i)*o[i];n.set(t,r,e)}}return n}strassen2x2(t){t=u.checkMatrix(t);let e=new u(2,2);const s=this.get(0,0),i=t.get(0,0),n=this.get(0,1),o=t.get(0,1),r=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(i+h),m=(r+l)*i,d=s*(o-h),g=l*(a-i),p=(s+n)*h,f=c+g-p+(n-l)*(a+h),y=d+p,b=m+g,w=c-m+d+(r-s)*(i+o);return e.set(0,0,f),e.set(0,1,y),e.set(1,0,b),e.set(1,1,w),e}strassen3x3(t){t=u.checkMatrix(t);let e=new u(3,3);const s=this.get(0,0),i=this.get(0,1),n=this.get(0,2),o=this.get(1,0),r=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),m=t.get(0,0),d=t.get(0,1),g=t.get(0,2),p=t.get(1,0),f=t.get(1,1),y=t.get(1,2),b=t.get(2,0),w=t.get(2,1),C=t.get(2,2),v=(s-o)*(-d+f),S=(-s+o+r)*(m-d+f),T=(o+r)*(-m+d),M=s*m,A=(-s+l+h)*(m-g+y),E=(-s+l)*(g-y),x=(l+h)*(-m+g),I=(-n+h+c)*(f+b-w),N=(n-c)*(f-w),L=n*b,_=(h+c)*(-b+w),R=(-n+r+a)*(y+b-C),O=(n-a)*(y-C),k=(r+a)*(-b+C),P=M+L+i*p,G=(s+i+n-o-r-h-c)*f+S+T+M+I+L+_,F=M+A+x+(s+i+n-r-a-l-h)*y+L+R+k,H=v+r*(-m+d+p-f-y-b+C)+S+M+L+R+O,V=v+S+T+M+a*w,W=L+R+O+k+o*g,B=M+A+E+h*(-m+g+p-f-y-b+w)+I+N+L,D=I+N+L+_+l*d,U=M+A+E+x+c*C;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,H),e.set(1,1,V),e.set(1,2,W),e.set(2,0,B),e.set(2,1,D),e.set(2,2,U),e}mmulStrassen(t){t=u.checkMatrix(t);let e=this.clone(),s=e.rows,i=e.columns,n=t.rows,o=t.columns;function r(t,e,s){let i=t.rows,n=t.columns;if(i===e&&n===s)return t;{let i=h.zeros(e,s);return i=i.setSubMatrix(t,0,0),i}}i!==n&&console.warn(`Multiplying ${s} x ${i} and ${n} x ${o} matrix: dimensions do not match.`);let a=Math.max(s,n),l=Math.max(i,o);return e=r(e,a,l),function t(e,s,i,n){if(i<=512||n<=512)return e.mmul(s);i%2==1&&n%2==1?(e=r(e,i+1,n+1),s=r(s,i+1,n+1)):i%2==1?(e=r(e,i+1,n),s=r(s,i+1,n)):n%2==1&&(e=r(e,i,n+1),s=r(s,i,n+1));let o=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,o-1,0,a-1),c=s.subMatrix(0,o-1,0,a-1),u=e.subMatrix(0,o-1,a,e.columns-1),m=s.subMatrix(0,o-1,a,s.columns-1),d=e.subMatrix(o,e.rows-1,0,a-1),g=s.subMatrix(o,s.rows-1,0,a-1),p=e.subMatrix(o,e.rows-1,a,e.columns-1),f=s.subMatrix(o,s.rows-1,a,s.columns-1),y=t(h.add(l,p),h.add(c,f),o,a),b=t(h.add(d,p),c,o,a),w=t(l,h.sub(m,f),o,a),C=t(p,h.sub(g,c),o,a),v=t(h.add(l,u),f,o,a),S=t(h.sub(d,l),h.add(c,m),o,a),T=t(h.sub(u,p),h.add(g,f),o,a),M=h.add(y,C);M.sub(v),M.add(T);let A=h.add(w,v),E=h.add(b,C),x=h.sub(y,b);x.add(w),x.add(S);let I=h.zeros(2*M.rows,2*M.columns);return 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strict";s.r(e),s.d(e,{BYPASS_LARGE_DATA_WARNING:()=>Ke,GetRegionEditor:()=>os,SeqActivityCliffsEditor:()=>ls,SeqPaletteCustom:()=>Qe,SequenceSpaceEditor:()=>as,SplitToMonomersEditor:()=>rs,SubsequenceSearchTopMenu:()=>Hs,_package:()=>$e,activityCliffs:()=>Cs,addCopyMenu:()=>zs,alignSequences:()=>Ms,bioSubstructureFilter:()=>Ds,compositionAnalysis:()=>As,compositionAnalysisWidget:()=>ms,convertDialog:()=>Is,demoBioActivityCliffs:()=>$s,demoBioAtomicLevel:()=>Ks,demoBioHelmMsaSequenceSpace:()=>js,demoBioSequenceSpace:()=>qs,demoBioSimilarityDiversity:()=>Xs,diversitySearchTopMenu:()=>Gs,diversitySearchViewer:()=>Ps,enumeratorColumnChoice:()=>Js,fastaSequenceCellRenderer:()=>cs,getBioLib:()=>ss,getEnumeratorWidget:()=>Qs,getHelmMonomers:()=>Rs,getMonomerLibHelper:()=>je,getRegion:()=>bs,getRegionApp:()=>Zs,getRegionHelmApp:()=>Ys,getRegionPanel:()=>is,getRegionTopMenu:()=>ws,hydrophobPalette:()=>Je,importBam:()=>xs,importFasta:()=>Es,initBio:()=>ts,libraryPanel:()=>ns,macroMolColumnPropertyPanel:()=>us,macromoleculeDifferenceCellRenderer:()=>gs,monomerCellRenderer:()=>Ns,multipleSequenceAlignmentDialog:()=>Ts,packageSettingsEditor:()=>hs,saveAsFasta:()=>Bs,sdfToJsonLib:()=>ti,searchSubsequenceEditor:()=>Fs,separatorSequenceCellRenderer:()=>ds,sequenceAlignment:()=>ps,sequenceIdentityScoring:()=>Vs,sequenceSimilarityScoring:()=>Ws,sequenceSpaceTopMenu:()=>vs,sequenceTooltip:()=>es,similaritySearchTopMenu:()=>ks,similaritySearchViewer:()=>Os,splitToMonomersTopMenu:()=>_s,testDetectMacromolecule:()=>Ls,toAtomicLevel:()=>Ss,vdRegionsViewer:()=>ys,webLogoLargeApp:()=>Us,webLogoViewer:()=>fs});var i=s(4469),n=s(3870),o=s(976),r=s(6414),a=s.n(r),l=s(585);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",m=l.GU;var d,g;function p(t,e,s,i,n,o,r=h,a=0,l=!1,d=1,p="",f=!1,y=g.classic,b=[],w=0,C=null,v=[],S=null,T={}){n.textAlign="start";let M=o.substring(0),A=f?"":p;y===g.MSA&&(A="");let E=!0,x=!0,I="difference";null!=C&&null!=C.cell.column&&(E=C.cell.column.temp["color-code"]??!0,x=C.cell.column.temp["compare-with-current"]??!0,I=C.cell.column.temp["highlight-difference"]??"difference");const N=v[w];x&&v.length>0&&"difference"===I&&(d=M==N?.3:d),x&&v.length>0&&"equal"===I&&(d=M!=N?.3:d),null!=S&&(M=m(M,S));const L=M+A;T[L]??(T[L]=n.measureText(L));let _=T[L];T[M]??(T[M]=n.measureText(M));let R=T[M].width;T[A]??(T[A]=n.measureText(A));const O=T[A].width,k=i/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,i){const o=E?r:u;n.fillStyle=o,n.globalAlpha=d,y===g.classic&&(n.fillText(M,t+s,e+k),n.fillStyle=c,n.fillText(A,t+i,e+k)),y===g.MSA&&n.fillText(M,t+s,e+k)}_=_.width,y===g.MSA&&(R=b[w],_=b[w]);const G=(b[w]??0)-(b[0]??0);if(l||_>s)return P(G,G+R),t+G+R+O;{const e=(s-_)/2;return P(e,e+R),t+G+e+R}}!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(d||(d={})),function(t){t.MSA="MSA",t.classic="classic"}(g||(g={}));var f,y=s(9611),b=s(8447),w=s(7331),C=s(499);!function(t){t.long="long",t.short="short"}(f||(f={}));const v={true:"1",false:"0"};var S=s(3553);const T="rgb(100,100,100)",M=b.GU;function A(t,e,s,i,n){return t?Math.max(Math.min(t.canvas.width/n-s,i)):Math.max(e.canvas.width/n-s,0)}function E(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],i=e?"":" ";for(const[e,n]of a().enumerate(t)){let o=e;n<t.length&&(o+=`${e?"":"-"}${i}`),s.push(o)}return[s,e]}class x extends o.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const o=t.bounds,r=e.offsetX-t.gridColumn.left+(t.gridColumn.left-o.x),a=s.getPosition(t.tableRowIndex,r),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],o=[n.div(t)];if(s._monomerStructureMap[t])o.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const n={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},r=i.chem.svgMol(e.smiles,void 0,void 0,n);o.push(r),s._monomerStructureMap[t]=r}}n.tooltip.show(n.divV(o),e.x+16,e.y+16)}else n.tooltip.hide()}render(t,e,s,i,n,r,l){let h=0,c=50;const u=r.grid,m=r.cell.column;if(!u||!m)return;const f=m.temp,w=f["monomer-width"];if("short"===(null!=w?w:"short")){const t=parseInt(m.getTag(d.maxMonomerLength));c=(isNaN(t)?$e.properties?.MaxMonomerLength:t)??4}let S=m.temp["bio-seqCol"];S||(S=new y.A(u,m,(()=>{const t=C.Cn.getOrCreate(m);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:h,monomerToShort:M,monomerLengthLimit:c,monomerLib:ss()}}))),m.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(h=f[".mm.cellRenderer.gapLength"]??h,S.setMonomerLengthLimit(c),S.setSeparatorWidth(S.isMsa()?8:h),m.setTag(".mm.cellRenderer.settingsChanged",v.false));const[E,x]=S.getCellMonomerLengths(r.tableRowIndex);E.length,S.updated&&(f["bio-seqCol"]=S),t.save();try{const l=window.devicePixelRatio,h=-1!==r.gridRow?r.grid:null,u=r.cell.value,d=m.getTag("alphabet"),y=50;i=A(h,t,e,i,l),t.beginPath(),t.rect(e+this.padding,s+this.padding,i-this.padding-1,n-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const w=m.getTag(o.TAGS.UNITS),v=m.getTag("aligned"),M=(0,b.py)(d),E=m.getTag("separator")??"",I=i/5,N=C.Cn.getOrCreate(m).getSplitter(I),L=f["reference-sequence"],_=f["current-word"],R=N(null!=L&&""!=L?L:_??""),O=N(u);let k=T,P=g.classic;v&&v.includes("MSA")&&w==b.r2.SEPARATOR&&(P=g.MSA);for(const[o,l]of a().enumerate(O)){k=M.get(o),t.fillStyle=T;const a=l===O.length-1;if(p(e+this.padding,s,i,n,t,o,k,0,!0,1,E,a,P,x,l,r,R,c,S._monomerLengthMap),y>i)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";$e.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class I extends o.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return S.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,i,n,r,a){const h=window.devicePixelRatio,c=r.grid,u=r.cell,m=r.tableColumn,d=u.value??"",g=m.tags.separator,p=m.tags[o.TAGS.UNITS];i=A(c,t,e,i,h);const[f,y]=d.split("#"),b=(0,l.vU)(p,g);N(t,e,s,i,n,b(f),b(y),p)}}function N(t,e,s,i,n,o,r,l,h,c){if(o.length!==r.length){const t=function(t,e){let s=0,i=0;const n=t.length>e.length?t:e,o=t.length>e.length?e:t;for(let t=0;t<o.length;t++)n[t]===o[t]&&s++;const r=n.length-o.length;for(let t=n.length-1;t>r;t--)n[t]===o[t-r]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(o).toArray(),a()(r).toArray());o=t.subParts1,r=t.subParts2}const u=t.measureText(E(o).join("")),m=t.measureText(E(r).join("")),d=Math.max(u.width,m.width);h&&(i=d+4*o.length,t.canvas.width=d+4*o.length);let g=Math.max(e,e+(i-(d+4*o.length))/2)+5;const f=Math.max(s,s+(n-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?d+4*o.length:i,n),t.clip(),t.font="12px monospace",t.textBaseline="top";let y=w.UE.Color;"HELM"!=l&&(y=(0,b.py)(l.substring(l.length-2)));for(let e=0;e<o.length;e++){const s=o[e],a=r[e],l=y.get(s);if(s!=a){const o=y.get(a),r=p(g,f-7,i,n,t,s,l,0,!0),h=p(g,f+7,i,n,t,a,o,0,!0);g=Math.max(h,r),c&&(c[e]=L(s,a,l,o,f,7,n))}else g=p(g,f,i,n,t,s,l,0,!0,.5);g+=4}t.restore()}function L(t,e,s,i,n,o,r){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(E([t]).join("")).width,c=l.measureText(E([e]).join("")).width,u=Math.max(h,c);return a.height=r,a.width=u+4,l.font="12px monospace",l.textBaseline="top",p(0,n-o,u,r,l,t,s,0,!0),p(0,n+o,u,r,l,e,i,0,!0),a}var _,R=s(701),O=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(_||(_={}));const k=new class{constructor(){this.regionTypes=[_.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=O.ES.Entropy,this.filterSource=O.vS.filterSource}};var P=s(833);const G=_;var F,H;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(F||(F={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(H||(H={}));const V=k;class W extends o.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(H.skipEmptyPositions,V.skipEmptyPositions,{category:F.DATA}),this.regionTypes=this.stringList(H.regionTypes,V.regionTypes,{category:F.DATA,choices:Object.values(G).filter((t=>t!=G.Unknown))}),this.chains=this.stringList(H.chains,V.chains,{category:F.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(H.fitWidth,V.fitWidth,{category:F.LAYOUT}),this.positionWidth=this.float(H.positionWidth,V.positionWidth,{category:F.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(H.positionHeight,V.positionHeight,{category:F.LAYOUT,choices:Object.keys(O.ES)}),this.filterSource=this.string(H.filterSource,V.filterSource,{category:F.BEHAVIOR,choices:Object.values(O.Ct)})}async init(){this.subs.push((0,R.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){if(this.setDataInProgress)return;const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t()}))}onTableAttached(){super.onTableAttached(),this.setData(this.dataFrame,this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case H.regionTypes:case H.chains:this.setData(this.dataFrame,this.regions)}switch(t.name){case H.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case H.fitWidth:case H.positionWidth:this.calcSize();break;case H.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.positionHeight]:this.positionHeight});this.calcSize();break;case H.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.dataFrame,this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t,e){this.setDataInProgress||(this.setDataInProgress=!0,$e.logger.debug("Bio: VdRegionsViewer.setData()"),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView("setData"),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.regions=e,this.dataFrame.dart!==t.dart&&(this.dataFrame=t)})).then((async()=>{this.viewed||(await this.buildView("setData"),this.viewed=!0)})).catch((t=>{const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),$e.logger.error(e,void 0,s)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(t){$e.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}'`),this.filterSourceInput&&n.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){$e.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}'`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<s.length;t++)for(const n of this.chains){const o=e.find((e=>e.order==s[t]&&e.chain==n));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,n,e]})())}const o=await Promise.all(i);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of o)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=n.table(this.chains,(t=>[...s.length>0?[n.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",n.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=n.choiceInput("Data source",this.filterSource,Object.values(O.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=n.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),$e.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){$e.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,s=13,i=9,n=(this.root.clientWidth-t-(this.logos.length-1)*i-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[P.bo.positionWidth]:n-s.positionMarginValue}),s.root.style.width=n*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[P.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=this.filterSourceInput.value;this.viewPromise=this.viewPromise.then((()=>{if(this.filterSource!==t){this.props.getProperty(H.filterSource).set(this,t);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const s=this.chains[e];this.logos[t][s].setOptions({[P.bo.filterSource]:this.filterSource})}}}))}}var B=s(9017),D=s(850);const U="dimensionality-reducer-terminate-event";async function Z(t,e,n,o,r,a){const l=await async function(t,e,n,o,r){return new Promise((function(a,l){const h=new Worker(new URL(s.p+s.u(196),s.b));h.postMessage({columnData:t.data,method:e,measure:t.metric,options:n,parallelDistanceWorkers:o});const c=i.events.onCustomEvent(U).subscribe((()=>{try{h?.terminate()}finally{c.unsubscribe()}}));h.onmessage=({data:{error:t,distance:e,embedding:s,epochNum:i,epochsLength:n}})=>{i&&n?r&&r(i,n,s):(c.unsubscribe(),t?l(t):a({distance:e,embedding:s}),setTimeout((()=>h.terminate()),0))}}))}({data:t,metric:n},e,o,r,a);return l.embedding=l.embedding.map((t=>(0,D.Fv)(t))),l}var Y=s(7983),z=s(7228),X=s(489);async function q(t,e){const s=C.Cn.getOrCreate(t.seqCol),i=t.seqCol.toList(),n=s.getSplitter(),r=i.length;let a=36;const l=new Map;for(let e=0;e<r;e++){const s=i[e];if(null===i[e]||t.seqCol.isNone(e)){i[e]=null;continue}i[e]="";const o=n(s);for(let t=0;t<o.length;t++){const s=o[t];l.has(s)||(l.set(s,String.fromCharCode(a)),a++),i[e]+=l.get(s)}}if(t.similarityMetric===X.U.MONOMER_CHEMICAL_DISTANCE){const e=Array.from(l.keys()),s=await(0,z.PF)(e);s.scoringMatrix.forEach(((t,e)=>{t.forEach(((t,i)=>{s.scoringMatrix[e][i]=1-t}))}));const i={};Object.entries(s.alphabetIndexes).forEach((([t,e])=>{i[l.get(t)]=e})),t.options.distanceFnArgs={scoringMatrix:s.scoringMatrix,alphabetIndexes:i}}const h=await Z(i,t.methodName,t.similarityMetric,t.options,!0,e),c=t.embedAxesNames.map(((t,e)=>o.Column.fromFloat32Array(t,h.embedding[e])));return{distance:h.distance,coordinates:new o.ColumnList(c)}}function $(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var K=s(5697),j=s(3379),J=s.n(j),Q=s(7795),tt=s.n(Q),et=s(569),st=s.n(et),it=s(3565),nt=s.n(it),ot=s(9216),rt=s.n(ot),at=s(4589),lt=s.n(at),ht=s(9414),ct={};ct.styleTagTransform=lt(),ct.setAttributes=nt(),ct.insert=st().bind(null,"head"),ct.domAPI=tt(),ct.insertStyleElement=rt(),J()(ht.Z,ct),ht.Z&&ht.Z.locals&&ht.Z.locals;var ut=s(3914),mt=s(6254);let dt=0;const gt="cliffsDf",pt=new R.Subject,ft="act_diff",yt="sali",bt="sim",wt="line_index",Ct=["1_seq","2_seq"],vt="filterCliffs";function St(t,e,s){const i=e.getBoundingClientRect(),n=t.clientX-i.left,o=t.clientY-i.top;let r=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-n,t.a[1]-o)+Math.hypot(t.b[0]-n,t.b[1]-o)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,r=t)}return r}var Tt=s(6361);async function Mt(t,e,s,n,r){e.version!==e.temp["last-invalidated-version"]&&await(0,Y.HV)(e,!1);const a=o.DataFrame.create(e.length);return a.columns.addNewString(n).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:n,simArr:r})}function At(t){const e=n.divH([]),s=n.divV([n.divText(t.seqCol.name),n.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,i)=>{const o=n.divText(t.activityCol.get(s).toFixed(2));o.style.display="flex",o.style.justifyContent="left",o.style.paddingLeft="30px",e.append(n.divV([n.divText(t.seqCol.get(s)),o]))})),e}function Et(t){const e=n.div();e.append(n.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),i=new Array(2);t.line.mols.forEach(((e,n)=>{s[n]=t.seqCol.get(e),i[n]=t.activityCol.get(e)}));const o={},r=C.Cn.getOrCreate(t.seqCol),a=r.getSplitter(),l=It(a(s[0]),a(s[1]),r.units,o);return e.append(n.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(Nt(o)),e.append(xt("Activity delta",Math.abs(i[0]-i[1]))),e.append(xt("Cliff",t.sali)),e}function xt(t,e){return n.divH([n.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),n.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function It(t,e,s,i){const n=document.createElement("canvas"),o=n.getContext("2d");return n.height=30,N(o,0,0,0,30,t,e,s,!0,i),n}function Nt(t){const e=n.div();if(Object.keys(t).length>0){const s=n.divV([]);s.append(n.divH([n.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),n.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(n.divH([n.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function Lt(t,e){const s=o.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(o.TAGS.UNITS,t.col(e[0]).getTag(o.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}var _t=s(4004),Rt=s(8601),Ot=s(5226);s(9133);class kt extends o.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[o.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",K.kg[0],{choices:K.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(o.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(o.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>this.render(t)))),this.subs.push(o.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(o.debounce(n.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(o.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===o.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==o.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Pt=s(7241),Gt=s(4293),Ft=s(2669);async function Ht(t){const e=t.toList();if(t.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=C.Cn.getOrCreate(t).getDistanceFunctionName(),i=new Ft.m(!0,!1),n=await i.calc(e,s);return i.terminate(),n}function Vt(t){return(e,s)=>{const i=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?i(e,s):i(s,e)}}class Wt extends kt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new R.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=o.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=o.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const n=s.plot.grid();n.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));n.cell("score",r).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Gt.Y)(this.root,n.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Pt.D)(this.moleculeColumn),e=(o.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Ht(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=C.Cn.getOrCreate(t).getDistanceFunctionName(),r=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(r).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const o=Math.floor(s*i.length/r),u=s===a.length-1?Math.floor((s+1)*i.length/r):i.length;return new Promise(((s,r)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:n}})=>{t?r(t):(h=Math.min(h,i),c=Math.max(c,n),l.set(e,o),s())},t.postMessage({fnName:n,values:i,templateIdx:e,start:o,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=Vt(e),n=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,s)]:1-t[s]})));n.sort(((t,e)=>e.score-t.score));const r=Math.min(this.limit,e),a=n.slice(0,r);this.idxs=o.Column.int("indexes",r).init((t=>a[t].idx)),this.scores=o.Column.float("score",r).init((t=>a[t].score))}createPropertyPanel(t){const e=n.div(),s={},o=this.molCol?.name,r=t.col(o),a=C.Cn.getOrCreate(r),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(o,t.currentRowIdx)),u=It(h,c,a.units,s);e.append(n.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(n.divV([n.divText("Different sequence length:",{style:{fontWeight:"bold"}}),n.divText(`target: ${h.length} monomers`),n.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(Nt(s));const m=n.accordion(),d=n.element("i");d.className="grok-icon svg-icon svg-view-layout",m.addTitle(n.span([d,n.label("Similarity search")])),m.addPane("Differences",(()=>e),!0),i.shell.o=m.root}}var Bt=s(8518);class Dt extends kt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new R.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=o.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const i=o.DataFrame.fromColumns([s]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Gt.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Pt.D)(this.moleculeColumn);o.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Ht(this.moleculeColumn),e=this.moleculeColumn.length,s=Vt(e);this.renderMolIds=(0,Bt.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[s(e,i)]))}}var Ut=s(9943),Zt=s(4413),Yt=s(1061),zt=s(5490),Xt=s(116),qt=s(1040);const $t={[o.SEMTYPE.MOLECULE]:"Molecules",[o.SEMTYPE.MACROMOLECULE]:"Sequences"};class Kt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=n.inputs([]),this.methodsParams={[Xt.AL.UMAP]:new Xt.bD,[Xt.AL.T_SNE]:new Xt.aP},this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=n.columnInput($t[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.molColInput.onChanged((()=>this.onColumnInputChanged(t))),this.methodInput=n.choiceInput("Method",Xt.AL.UMAP,[Xt.AL.UMAP,Xt.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]),this.displaySimilarityThresholdInput(t)})),this.similarityThresholdInput=n.floatInput("Similarity threshold",.5),n.tooltip.bind(this.similarityThresholdInput.root,"Similarity threshold for sparse matrix creation."),this.methodSettingsIcon=n.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):n.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=n.inputs([]);let e=!1;this.similarityMetricInput=t===o.SEMTYPE.MOLECULE?n.choiceInput("Similarity",qt.gk.Tanimoto,K.Rt):n.choiceInput("Similarity",X.U.HAMMING,K.bc),setTimeout((()=>{this.displaySimilarityThresholdInput(t),this.onColumnInputChanged(t)}))}createAlgorithmSettingsDiv(t,e){return n.empty(t),Object.keys(e).forEach((s=>{const i=e[s],o=n.floatInput(i.uiName,i.value,(()=>{i.value=o.value}));n.tooltip.bind(o.root,i.tooltip),t.append(o.root)})),t}onTableInputChanged(t){this.molColInput=n.columnInput($t[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),this.molColInput.onChanged((()=>this.onColumnInputChanged(t))),n.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t))),this.displaySimilarityThresholdInput(t),this.onColumnInputChanged(t)}onColumnInputChanged(t){const e=this.molColInput.value;if(!e||t!==o.SEMTYPE.MACROMOLECULE)return;const s=(e.getTag("aligned")??" ").toUpperCase().includes("MSA");this.similarityMetricInput.value=s?X.U.HAMMING:X.U.LEVENSHTEIN}displaySimilarityThresholdInput(t){t!==o.SEMTYPE.MOLECULE&&this.tableInput.value&&this.tableInput.value.rowCount>2e4&&this.methodInput.value===Xt.AL.UMAP?this.similarityThresholdInput.root.style.display="block":this.similarityThresholdInput.root.style.display="none"}}class jt extends Kt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,sparseMatrixThreshold:this.similarityThresholdInput.value??.8,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=n.boolInput("Plot embeddings",!0),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.methodInput,this.similarityThresholdInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Jt extends Kt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,o.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=n.intInput("Similarity cutoff",80),n.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),n.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,o.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var Qt,te=s(8457);async function ee(t,e,s,i){const n=(0,te.O)(e),r=(0,l.vU)(e.getTag(o.TAGS.UNITS),e.getTag("separator"))(s),a=i===Qt.IDENTITY?function(t,e){const s=e.columns.length,i=new Array(s),n=new Array(s),r=new Array(s);for(let o=0;o<s;++o){const s=e.columns.byIndex(o);i[o]=s.getRawData(),n[o]=s.categories.indexOf(""),r[o]=s.categories.indexOf(t[o]??"")}const a=o.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)i[e][s]===r[e]&&++l[s];l[s]/=t.length}return a}(r,n):i===Qt.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,z.Qx)(s,t)}(r,n):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${i}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(Qt||(Qt={}));var se,ie=function(t,e,s,i){return new(s||(s=Promise))((function(n,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class ne{constructor(t,e,s=!1,i){var o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._stopStartBtn=n.button(n.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=n.button(n.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=n.button(n.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._closeBtn=n.button(n.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._progress.max=0,this._progress.value=1,ne.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=n.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(n.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=n.iconFA("clock");this._isAutomatic||0===e&&(s=n.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const i=n.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=n.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=n.divH([s,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){var t,e,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,o.DOCK_TYPE.FILL,n,""),(null===(e=null===(t=n.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return ie(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const r=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,r.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,i,a),yield(0,Yt.gw)(a));const l=n.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=n.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return ie(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return ie(this,void 0,void 0,(function*(){const i=n.div([],"demo-script-countdown");e.classList.add("hidden");let o=s/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,ne.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return ie(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function oe(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),$e.logger.error(t.message,void 0,s)}ne.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(se||(se={}));const re="data/sample_FASTA_PT_activity.csv";var ae=s(1811);async function le(){const t="Dendrogram",e=o.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function he(){return await i.functions.call("Dendrogram:getDendrogramService",{})}const ce="data/sample_FASTA_PT_activity.csv",ue="sequence";var me=s(3336),de=s.n(me);const ge="data/sample_FASTA_PT_activity.csv";var pe=s(8341);const fe="samples/HELM.csv";var ye=s(2568),be=s(525);class we{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${$e.name}.${this.funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case P.bo.fixWidth:case P.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Ce{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE};this.seqColInput=n.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=n.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=n.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE))}}var ve=s(9416);class Se{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const Te=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},Me={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class Ae{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const o=t.tableColumn.getTag("alphabet"),r=t.cell.value,a="DNA"===o||"RNA"===o?"RNA":"PEPTIDE",l=new Se(je().getBioLib()).getCappedRotatedMonomer(a,r),h=n.div(r),c=l?i.chem.svgMol(l,void 0,void 0,Me):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return n.tooltip.show(n.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){let e=t.temp[Te.tooltipHandlerTemp];return e||(e=t.temp[Te.tooltipHandlerTemp]=new Ae(t)),e}}class Ee extends o.GridCellRenderer{get name(){return S.Of.MONOMER}get cellType(){return S.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,i,n,o,r){if(o.gridRow<0)return;Ae.getOrCreate(o.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,b.py)(o.cell.column.getTag("alphabet")),l=o.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,b.GU)(l,6),e+i/2,s+n/2,i)}}class xe extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new R.Subject}}class Ie extends o.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(t){this._properties=t}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),this.logger.error(e,void 0,s)}}class Ne extends o.Widget{constructor(t){super(n.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=n.intInput("Max monomer length",$e.properties.MaxMonomerLength,(t=>{$e.properties.MaxMonomerLength=t})),e=n.boolInput("Tooltip WebLogo",$e.properties.TooltipWebLogo,(t=>{$e.properties.TooltipWebLogo=t})),s=n.choiceInput("Default Separator",$e.properties.DefaultSeparator,[".","/","-"],(t=>{$e.properties.DefaultSeparator=t}));this.root.appendChild(n.form([t,e,s]))}}var Le=s(5362),_e={};_e.styleTagTransform=lt(),_e.setAttributes=nt(),_e.insert=st().bind(null,"head"),_e.domAPI=tt(),_e.insertStyleElement=rt(),J()(Le.Z,_e),Le.Z&&Le.Z.locals&&Le.Z.locals;class Re extends o.Widget{constructor(t){super(n.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=C.Cn.getOrCreate(this.seqCol),e=$e.properties.TooltipWebLogo,s=this.seqCol.getTag(O.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const Oe="PEPTIDE1{",ke="}$$$$",Pe="<All>";function Ge(t){t.setTag("quality",o.SEMTYPE.MACROMOLECULE),t.setTag("aligned","SEQ"),t.setTag("alphabet","PT")}class Fe{constructor(t,e){this.helmColumn=t,this.leftTerminal=e.leftTerminal,this.rightTerminal=e.rightTerminal}transform(){return this.helmColumn.toList().map((t=>this.hasTerminals(t)?this.getTransformedHelm(t):t))}}class He extends Fe{constructor(t,e){super(t,e)}hasTerminals(t){return!!t.includes(this.rightTerminal+ke)&&(this.leftTerminal===Pe||t.includes(Oe+this.leftTerminal))}getLinkedPositions(t){return[1,De(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ue(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:3})}}class Ve extends Fe{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Pe||this.rightTerminal===Pe||t.includes(Oe+this.leftTerminal)&&t.includes(this.rightTerminal+ke)}getLinkedPositions(t){return[1,De(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ue(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:2})}}class We extends Fe{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Pe||this.rightTerminal===Pe||this.getLinkedPositions(t).every((t=>t>0))}getLinkedPositions(t){const e=t.replace(Oe,"").replace(ke,"").split("."),s=e.findIndex((t=>t===this.leftTerminal)),i=e.findIndex(((t,e)=>t===this.rightTerminal&&e>s));return[s+1,i+1]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ue(t,{monomerPosition:e[0],attachmentPoint:3},{monomerPosition:e[1],attachmentPoint:3})}}class Be{constructor(){}static getInstance(t,e){const s=e.cyclizationType;return"R3-R3"===s?new We(t,e):"N-Cys"===s?new He(t,e):new Ve(t,e)}}function De(t){return t.replace(Oe,"").replace(ke,"").split(".").length}function Ue(t,e,s){return t.replace(ke,`}$PEPTIDE1,PEPTIDE1,${e.monomerPosition}:R${e.attachmentPoint}-${s.monomerPosition}:R${s.attachmentPoint}${"$".repeat(6)}`)}async function Ze(t,e){const s=t.dataFrame,n=C.Cn.getOrCreate(t).convert(b.r2.HELM),r=Be.getInstance(n,e).transform(),a=s.columns.getUnusedName(`${e.transformationType}(`+t.name+")"),l=o.Column.fromList("string",a,r);Ge(l),l.setTag("units",b.r2.HELM),l.setTag("cell.renderer","helm"),s.columns.add(l),await i.data.detectSemanticTypes(s)}function Ye(t,e,s,i){const n=C.Cn.getOrCreate(t);let o=null,r=null;for(let t=0;t<n.posList.length;++t)n.posList[t]==e&&(o=t),n.posList[t]==s&&(r=t);if(null===o&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===r&&null!==s)throw new Error(`End position ${s} not found.`);if(n.posList.length<r)throw new Error(`End position ${r} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${s??""})`;return n.getRegion(o,r,a)}const ze={df:o.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(b.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class Xe{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??ze;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(".positionNames",this.data.positionNames),this.data.regions&&e.setTag(".regions",JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await i.data.detectSemanticTypes(this.data.df),this.view=i.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${$e.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,o.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class qe{constructor(t){this.call=t,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const e=t=>this.call.inputParams[t].property.description;this.inputs.table=n.tableInput("Table",this.call.inputParams.table.value??i.shell.tv.dataFrame,void 0,(()=>{}));const s=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE),r={filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE};this.inputs.sequence=n.columnInput("Sequence",i.shell.tv.dataFrame,s,this.sequenceInputChanged.bind(this),r),this.inputs.start=n.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=n.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=n.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=n.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const t in this.call.inputParams)n.tooltip.bind(this.inputs[t].captionLabel,e(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&C.Cn.getOrCreate(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=C.Cn.getOrCreate(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?C.Cn.getOrCreate(t):null,s=this.inputs.start.input,i=this.inputs.end.input;for(let t=s.options.length-1;t>=0;--t)s.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),n=document.createElement("option");e.text=n.text=t,e.value=n.value=t,s.options.add(e),i.options.add(n)}s.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(".regions"):null,s=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const n=document.createElement("option");if(n.text="",n.value=JSON.stringify(null),i.options.add(n),null!=s){this.inputs.region.root.style.removeProperty("display");for(const t of s){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",s=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const n=t.options[i],o=JSON.parse(n.value);o&&e===o.start&&s===o.end&&(t.selectedIndex=i)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,s=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";return null!=e?`${s.name}(${e.name}): ${e.start}-${e.end}`:`${s?.name}: (${i}-${n})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=n.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});n.dialog({title:"Get Region"}).add(t).onOK((async()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{$e.handleErrorUI(t)}))})).show()}widget(){const t=n.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=n.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{$e.handleErrorUI(t)}))}));return o.Widget.fromRoot(n.divV([t,n.div(e)]))}}const $e=new Ie,Ke="bypassLargeDataWarning";function je(){return zt.NT.instance}let Je=null;class Qe{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function ts(){$e.logger.debug("Bio: initBio(), started");const t=await i.functions.call("Chem:getRdKitModule");await Promise.all([(async()=>{await zt.NT.instance.loadLibraries()})(),(async()=>{const t=await $e.getProperties(),e=new xe(t);$e.properties=e})()]).finally((()=>{$e.completeInit()}));const e=zt.NT.instance.getBioLib(),s=[],n=[],o=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(o).forEach((e=>{s.push(e);const i=o[e].replaceAll("#R","O "),r=t.get_mol(i),a=JSON.parse(r.get_descriptors()).CrippenClogP;n.push(a),r?.delete()}));const r=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=n[t]<r?"#4682B4":"#DC143C";Je=new Qe(a),$e.logger.debug("Bio: initBio(), completed")}function es(t){const e=new Re(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();i.shell.error(e)})),e}function ss(){return zt.NT.instance.getBioLib()}function is(t){const e="getRegionTopMenu",s=o.Func.find({package:$e.name,name:e});if(1!==s.length)throw new Error(`Package '${$e.name}' func '${e}' not found`);const i=s[0].prepare({table:t.dataFrame,sequence:t});return new qe(i).widget()}async function ns(t){return(0,zt.cf)()}function os(t){try{new qe(t).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(`Get region editor error: ${e}`),$e.logger.error(e,void 0,s)}}function rs(t){const e=new Ce;n.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function as(t){const e=new jt(o.SEMTYPE.MACROMOLECULE);n.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call())).show()}function ls(t){const e=new Jt(o.SEMTYPE.MACROMOLECULE);n.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function hs(t){const e=new Ne(t);return e.init().then(),e}function cs(){return new x}function us(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===o.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=n.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:f.short,[f.short,f.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const i=parseInt(t.getTag(d.maxMonomerLength)),r=n.intInput("Max monomer length",isNaN(i)?$e.properties.MaxMonomerLength:i,(e=>{t.setTag(d.maxMonomerLength,e.toString()),t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));r.setTooltip(`The max length of monomer name displayed without shortening in '${f.short}' monomer width mode.`);const a=n.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));a.setTooltip("The size of margin between monomers (in pixels)");const l=n.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Color code");const h=n.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const c=n.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));c.setTooltip('When on, all sequences get rendered in the "diff" mode');const u=n.inputs([s,r,a,h,l,c]);return new o.Widget(u)}(t)}function ms(t){return function(t){const e=n.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let i=w.UE.Color;switch(s){case"DNA":case"RNA":i=(0,b.py)("DNA");break;case"PT":i=(0,b.py)("PT")}const r=new Map;let l=0;const h=C.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=r.get(t)||0;r.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},m=Array.from(r.entries());m.sort(((t,e)=>e[1]-t[1])),m.forEach((([t,e])=>{const s=e/c,o=i.get(t),r=n.div("",{classes:"macromolecule-cell-comp-analysis-bar"});r.style.width=s/l*50+"px";const a=n.div((100*s).toFixed(2)+"%");r.style.backgroundColor=o,u[t]=n.div([r,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const d=n.tableFromMap(u);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(d),new o.Widget(e)}(t)}function ds(){return new x}function gs(){return new I}function ps(t,e,s,i,n){const o=new B.k(i,n,s,e);return"Local alignment"==t?o.smithWaterman():o.needlemanWunch()}function fs(){return new P.OZ}function ys(){return new W}function bs(t,e,s,i){return Ye(t,e??null,s??null,i??null)}async function ws(t,e,s,n,o){const r=Ye(e,s??null,n??null,o??null);e.dataFrame.columns.add(r),await i.data.detectSemanticTypes(e.dataFrame)}async function Cs(t,e,r,a,l,h){if(!(0,ye.n)(e,"Activity Cliffs"))return;const c=$(t),u={units:e.getTag(o.TAGS.UNITS),aligned:e.getTag("aligned"),separator:e.getTag("separator"),alphabet:e.getTag("alphabet")},m=C.Cn.getOrCreate(e);let d=Tt.gk.Tanimoto,g=e;if(m.isFasta()||m.isSeparator()&&m.alphabet&&"UN"!==m.alphabet)if(m.isFasta())d=m.getDistanceFunctionName();else{g=m.convert(b.r2.FASTA);const t=C.Cn.getOrCreate(g);d=t.getDistanceFunctionName(),u.units=b.r2.FASTA}const p=async()=>await async function(t,e,r,a,l,h,c,u,m,d,g,p,f,y,b,w,C,v){dt++;const S=c/100,T=r??e;let M=!1,A=!1;const E={};let x,I;const N={seqCol:T,methodName:m,similarityMetric:u,embedAxesNames:a,options:C},{distance:L,coordinates:_}=await p(N);for(const e of _)t.columns.add(e);let R=L;const O=Object.values(X.U).map((t=>t.toString())).includes(u);O&&!L&&(R=ut.H.calc(e.toList(),X.o[u]()).data);const k=function(t,e,s){const i=[],n=[],o=[],r=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){o.push(l),r.push(l+h+1),a.add(l),a.add(l+h+1),i.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));n.push(1!=c?t/(1-c):1/0)}}return{simVals:i,saliVals:n,n1:o,n2:r,cliffsMolIds:a}}(await async function(t,e,s,i){const n=t.categories,r=t.getRawData(),a=o.Column.string("seq",t.length).init((t=>n[r[t]])),l=o.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const i=(0,mt.y)(t);for(let n=0;n<t-1;++n){const r=new Float32Array(t-n-1).fill(0);for(let s=n+1;s<t;++s){const t=i(n,s);r[s-n-1]=e[t]===o.FLOAT_NULL?0:(0,K.Om)(e[t])}s[n]=o.Column.fromFloat32Array("similarity",r)}}(h,e,c):c=await i(h,t,l,"seq",c),c}(T,R,O,f),S,h),P=function(t,e,s,i,n,r){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(r.get(s[t])>r.get(i[t])?a[s[t]]+=e[t]:a[i[t]]+=e[t]);return o.Column.fromList("double",`sali_${n[0].substring(n[0].lastIndexOf("_"))}`,a)}(T.length,k.saliVals,k.n1,k.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",i=t.columns.names().filter((t=>t.includes(s))).length+1,n=`${s}_${i}`;return o.Column.bool(n,t.rowCount).init((t=>e.has(t)))}(t,k.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(k.saliVals),H=.8/(F.max-F.min),V=i.shell.getTableView(t.name);V.grid.columns.byName(G.name).visible=!1;const W=V.addViewer(o.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),B=W.getInfo().canvas,D=function(t,e,s,i,n){const r=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],i=t.n2[e];r[e]={id:e,mols:[s,i],selected:!1,a:[],b:[]}}const a=o.DataFrame.create(r.length);return Ct.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(r[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),n),a.col(t).semType=i})),a.columns.addNewFloat(ft).init((t=>Math.abs(s.get(r[t].mols[0])-s.get(r[t].mols[1])))),a.columns.addNewInt(wt).init((t=>t)),a.columns.addNewFloat(yt).init((e=>t.saliVals[e])),a.columns.addNewFloat(bt).init((e=>t.simVals[e])),a.name=`${gt}${dt}`,{lines:r,linesDf:a}}(k,e,h,d,g),U=w?w(D.linesDf,Ct).sort([yt],[!1]):D.linesDf.plot.grid().sort([yt],[!1]);t.temp[".cliffsDfGrid"]=U;const Z=n.button(`${D.linesDf.rowCount} cliffs`,(()=>{V.dockManager.dock(U,"down",null,"Activity cliffs",v??.2)}));Z.classList.add("scatter_plot_link","cliffs_grid"),W.root.append(Z);const Y=n.switchInput("Show only cliffs",!1,(()=>{Y.value?(W.dataFrame.setTag(vt,G.name),t.rows.match({[G.name]:!0}).filter(),pt.next(G.name)):(W.dataFrame.setTag(vt,""),t.filter.setAll(!0,!0),pt.next(""))}));Y.root.classList.add("scatter_plot_link","show_only_cliffs"),W.root.append(Y.root),pt.subscribe((t=>{Y.enabled=""===t||t===G.name}));const z=i.events.onViewerClosed.subscribe((t=>{t.args.viewer===W&&(V.dockManager.close(U.root),z.unsubscribe(),V.subs=V.subs.filter((t=>t!==z)))}));return V.subs.push(z),D.linesDf.onCurrentCellChanged.subscribe((()=>{M=!0;const s=D.linesDf.currentCol&&D.linesDf.currentCol.name===Ct[1]?1:0,o=-1!==D.linesDf.currentRowIdx?D.lines[D.linesDf.currentRowIdx]:null;W.dataFrame.currentRowIdx=o?o.mols[s]:-1,W.dataFrame.filter.set(0,!D.lines[0].selected),W.dataFrame.filter.set(0,D.lines[0].selected),o&&setTimeout((()=>{!function(t,e,s,o,r,a,l,h){const c=e.getPane("Cliff Details");n.empty(c.root);const u=h({cashedData:s,line:o,df:t,seqCol:r,activityCol:a,sali:l});c.root.append(u),setTimeout((()=>{i.shell.o=e.root}),500)}(t,x,E,o,e,h,D.linesDf.get(yt,o.id),b);const s=W.dataFrame.getSortedOrder(V.grid.sortByColumns,V.grid.sortTypes);V.grid.scrollToCell(e.name,s.indexOf(W.dataFrame.currentRowIdx))}),1e3)})),D.linesDf.onSelectionChanged.subscribe((e=>{if(!1===D.linesDf.selection.anyTrue)D.lines.forEach((t=>{t.selected=!1}));else if(-1!==D.linesDf.mouseOverRowIdx){const t=D.lines[D.linesDf.mouseOverRowIdx];t.selected=!t.selected}setTimeout((()=>{const e=o.BitSet.create(t.rowCount);D.lines.forEach((t=>{t.selected&&t.mols.forEach((s=>{e.set(s,t.selected,!0)}))})),t.selection.copyFrom(e),V.grid.invalidate()}),300)})),t.onSelectionChanged.subscribe((e=>{A?A=!1:!1===t.selection.anyTrue&&"number"==typeof e&&(D.lines.forEach((t=>{t.selected=!1})),U.dataFrame.selection.setAll(!1,!1),U.invalidate())})),B.addEventListener("mousemove",(function(i){clearTimeout(I),I=s.g.setTimeout((function(){const s=St(i,B,D.lines);s&&-1===t.mouseOverRowIdx&&n.tooltip.show(y({cashedData:E,line:s,df:t,seqCol:e,activityCol:h}),i.clientX,i.clientY)}),500)})),B.addEventListener("mousedown",(function(e){A=!0;const s=St(e,B,D.lines);if(s&&-1===t.mouseOverRowIdx){e.ctrlKey?(s.selected=!s.selected,D.linesDf.selection.set(s.id,s.selected)):D.linesDf.currentRowIdx!==s.id&&(D.linesDf.currentRowIdx=s.id,t.currentRowIdx=s.mols[0],t.filter.set(0,!D.lines[0].selected),t.filter.set(0,D.lines[0].selected));const i=D.linesDf.getSortedOrder(U.sortByColumns,U.sortTypes);U.scrollToCell(Ct[0],i.indexOf(s.id))}})),W.onEvent("d4-before-draw-scene").subscribe((e=>{const s=function(t,e,s,i,n,o,r){const a=i.lines,l=t.getInfo().canvas.getContext("2d"),h=t.dataFrame.columns.byName(e),c=t.dataFrame.columns.byName(s);for(let e=0;e<a.length;e++){const s=t.worldToScreen(h.get(a[e].mols[0]),c.get(a[e].mols[0])),u=t.worldToScreen(h.get(a[e].mols[1]),c.get(a[e].mols[1]));a[e].a=[s.x,s.y],a[e].b=[u.x,u.y];const m=new Path2D;m.moveTo(a[e].a[0],a[e].a[1]);const d=a[e].selected?"255,255,0":"0,128,0",g=n[e]===1/0?1:.2+(n[e]-r)*o;l.strokeStyle=`rgba(${d},${g})`,l.lineWidth=a[e].id===i.linesDf.currentRowIdx?3:1,m.lineTo(a[e].b[0],a[e].b[1]),l.stroke(m)}return a}(W,a[0],a[1],D,k.saliVals,H,F.min);if(M){const t=s[D.linesDf.currentRowIdx];setTimeout((()=>{const{zoomLeft:e,zoomRight:s,zoomTop:i,zoomBottom:n}=function(t,e,s,i,n,o){const r=Math.abs(s-n),a=Math.abs(i-o),l=t/r,h=e/a,c=Math.min(l,h),u=t/c*5,m=e/c*5,d=(s<n?s:n)+r/2-u/2,g=(i>o?i:o)-a/2+m/2;return{zoomLeft:d,zoomRight:d+u,zoomTop:g,zoomBottom:g-m}}(W.viewport.width,W.viewport.height,W.dataFrame.get(a[0],t.mols[0]),W.dataFrame.get(a[1],t.mols[0]),W.dataFrame.get(a[0],t.mols[1]),W.dataFrame.get(a[1],t.mols[1]));W.zoom(e,i,s,n)}),300),M=!1}Y.value?t.rows.match({[G.name]:!0}).filter():!0===Y.enabled&&t.filter.setAll(!0,!1)})),W.addProperty("similarityLimit","double",S),x=function(){const t=n.accordion(),e=n.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(n.span([e,n.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>n.divText("Cliff has not been selected")),!0),i.shell.o=t.root,t}(),W}(t,g,null,c,"Activity cliffs",r,a,d,l,o.SEMTYPE.MACROMOLECULE,u,q,Mt,At,Et,Lt,h),f=l===Xt.AL.UMAP?5e3:2e3;if(t.rowCount>2e4)i.shell.warning("Too many rows, maximum for sequence activity cliffs is 20000");else{if(!(t.rowCount>f)||h?.[Ke])return await p();n.dialog().add(n.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=o.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),e=await p();return t.close(),e})).show()}}async function vs(t,e,s,r=X.U.LEVENSHTEIN,a,l,h){if(await(0,Yt.gw)(10),!(0,ye.n)(e,"Sequence space"))return;let c;const u=o.TaskBarProgressIndicator.create("Initializing sequence space ...");try{function m(e,s,n){let r=null,l=null;t.columns.names().includes(d[0])?(r=t.columns.byName(d[0]),l=t.columns.byName(d[1])):(r=t.columns.add(o.Column.float(d[0],t.rowCount)),l=t.columns.add(o.Column.float(d[1],t.rowCount)),a&&(c=i.shell.tableView(t.name).scatterPlot({x:d[0],y:d[1],title:"Sequence space"}))),r.init((t=>n[t][0])),l.init((t=>n[t][1]));const h=e/s*100;u.update(h,`Running sequence space ... ${h.toFixed(0)}%`)}const d=$(t),g=o.DataFrame.fromColumns([e]).clone(),p=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],n=[];let o=0;for(let e=0;e<t.rowCount;e++)s.includes(i[e])&&(t.rows.removeAt(e-o),n.push(e),o+=1);return n}(g,e),f={seqCol:g.col(e.name),methodName:s,similarityMetric:r,embedAxesNames:d,options:{...h,sparseMatrixThreshold:l??.8,usingSparseMatrix:t.rowCount>2e4}},y=s===Xt.AL.UMAP?1e5:15e3,b=s===Xt.AL.UMAP?5e3:2e3;if(t.rowCount>y)return void i.shell.warning(`Too many rows, maximum for sequence space is ${y}`);async function w(){let t=null;const e=i.events.onViewerClosed.subscribe((s=>{const n=s.args.viewer;n?.getOptions()?.look?.title&&c?.getOptions()?.look?.title&&n?.getOptions()?.look?.title===c?.getOptions()?.look?.title&&(i.events.fireCustomEvent(U,{}),e.unsubscribe(),t?.(),u.close())})),s=new Promise((async e=>{t=e,e(await q(f,h?.[Ke]?void 0:m))})),n=await s;return u.close(),e.unsubscribe(),n?C(n):n}if(!(t.rowCount>b)||h?.[Ke])return await w();function C(e){const s=e.coordinates;for(const e of s){const s=e.toList();p.forEach((t=>s.splice(t,0,null)));let i=t.columns.byName(e.name);i||(i=o.Column.float(e.name,s.length),t.columns.add(i)),i.init((t=>s[t]))}if(a)return c||(c=i.shell.tableView(t.name).scatterPlot({x:d[0],y:d[1],title:"Sequence space"})),c}n.dialog().add(n.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{await w()})).onCancel((()=>{u.close()})).show()}catch(v){console.error(v),u.close()}}async function Ss(t,e){if(0===o.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,ye.n)(e,"To Atomic Level"))return;const s=(await je()).getBioLib(),r=await(0,Rt.i0)(t,e,s);null!==r.col&&(t.columns.add(r.col,!0),await i.data.detectSemanticTypes(t)),r.warnings&&r.warnings.length>0&&i.shell.warning(n.list(r.warnings))}function Ts(){(0,be.K)()}async function Ms(t=null,e=null){return(0,be.K)({col:t,clustersCol:e})}async function As(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==o.SEMTYPE.MACROMOLECULE&&(C.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,ye.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let r=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>C.Cn.getOrCreate(t).isMsa())),o=n.choiceInput("Column",i?i.name:t[0],t);n.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(n.div([o])).onOK((async()=>{const t=e.find((t=>t.name==o.value))??null;t&&await s(t)})).show()}else r=e[0];r&&await s(r)}else i.shell.error("Current table does not contain sequences")}function Es(t){return new Ot.i(t).importFasta()}function xs(t){return console.log(t),[]}function Is(){const t=(0,Gt.B)()[0];(0,_t.O)(t)}function Ns(){return new Ee}async function Ls(t){const e=o.TaskBarProgressIndicator.create("Test detectMacromolecule..."),s=(await i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let n=0;const r=[];for(const a of s)try{const e=await i.dapi.files.readAsText(t+a.fullPath),s=o.DataFrame.fromCsv(e);for(const t of s.columns)await i.functions.call("Bio:detectMacromolecule",{col:t})===o.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(o.TAGS.UNITS)}`})}catch(t){r.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{n+=1,e.update(100*n/s.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=o.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${t}`,a}async function _s(t,e){await(0,ve.n)(t,e)}function Rs(t){const e=C.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function Os(){return new Wt}function ks(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Ps(){return new Dt}function Gs(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Fs(t){const e=(0,Gt.B)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new Y.uH(e)}function Hs(t){i.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),i.shell.tv.grid.scrollToCell(t,0)}async function Vs(t,e,s){return ee(t,e,s,Qt.IDENTITY)}async function Ws(t,e,s){return ee(t,e,s,Qt.SIMILARITY)}function Bs(){(0,Ut.C2)()}function Ds(){return new Zt.ST}async function Us(){const t=o.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new we(t,"webLogoLargeApp"),s=await $e.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(s),await e.init(s)}finally{t.close()}}async function Zs(){const t=o.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new Xe(t,"getRegionApp");await e.init()}finally{t.close()}}async function Ys(){const t=o.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await $e.files.readCsv("data/sample_HELM_empty_vals.csv"),s=new Xe(t,"getRegionHelmApp");await s.init({df:e,colName:"HELM"})}finally{t.close()}}function zs(t,e){!function(t,e){const s=C.Cn.getOrCreate(t.column),n=Object.values(b.r2).filter((t=>t!==s.units));e.group("Copy").items(n,(e=>{const s=C.Cn.getOrCreate(t.column),n=e===b.r2.SEPARATOR?$e.properties.DefaultSeparator:void 0,o=s.getConverter(e,n)(t.value);navigator.clipboard?(navigator.clipboard.writeText(o),i.shell.info(`Value of notation '${e}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function Xs(){await async function(){let t,e;try{const s=new ne("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await $e.files.readCsv(re),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,o.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){oe(t)}}()}async function qs(){await async function(){let t,e,s,n,r;try{const a=new ne("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[n,t,e]=await Promise.all([$e.files.readCsv(ce),le(),he()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(t,e,s,i){let n;{const t=Object.values(se);for(let s=0;s<t.length;s++){const i=t[s];if(!e.col(i)){const n=s==t.length-1;e.columns.add(o.Column.float(i,e.rowCount),n)}}if(e.rowCount>=1){const i=e.getCol(s).toList(),n=Date.now();$e.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const o=await Z(i,"UMAP",Tt.W.Levenshtein,{}),r=Date.now();$e.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(r-n)/1e3} s`);for(let s=0;s<t.length;s++){const i=t[s],n=e.getCol(i),r=o.embedding[s];n.init((t=>r[t]))}const a=Date.now();$e.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-r)/1e3} s`)}n=await e.plot.fromType(o.VIEWER.SCATTER_PLOT,{xColumnName:se.X,yColumnName:se.Y,lassoTool:!0})}return t.dockManager.dock(n,o.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),n}(s,n,ue)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol(ue).toList(),o=ut.H.calc(i,((t,e)=>ae.T(t,e)/((t.length+e.length)/2))),r=await t.hierarchicalClusteringByDistance(o,"ward");e.injectTreeForGrid(s.grid,r,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{n.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=n.getCol("sequence_id");n.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),n.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){oe(t)}}()}async function $s(){await async function(){let t,e,s,n,r;const a=Xt.AL.UMAP;try{const l=new ne("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([$e.files.readCsv(ge),le(),he()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=300,n.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{r=await Cs(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),n.dockManager.dock(r,o.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),de()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=o.TaskBarProgressIndicator.create("Running sequence clustering..."),r=s.getCol("sequence").toList(),a=ut.H.calc(r,((t,e)=>ae.T(t,e)/((t.length+e.length)/2))),l=await t.hierarchicalClusteringByDistance(a,"ward");i.close(),e.injectTreeForGrid(n.grid,l,void 0,150,void 0),n.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=r.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){oe(t)}}()}async function Ks(){await async function(){const t="HELM";let e,s,r;try{await new ne("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await $e.files.readCsv("samples/HELM.csv"),s=i.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const i=s.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await Ss(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const i=e.currentCell.value,a=new o.chem.Sketcher(o.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),r=n.dialog().add(a).show(),await(0,Yt.gw)(3e3),r.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){oe(t)}}()}async function js(){await async function(){let t,e,s,n,r,a;const l="msa(HELM)",h=Xt.AL.UMAP;try{const c=new ne("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await $e.files.readCsv(fe)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=pe.J[0];n=await(0,pe.f)(s,l,t,1.53,0,void 0),e.columns.add(n),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await vs(e,n,h,X.U.LEVENSHTEIN,!0),t.dockManager.dock(a,o.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(r,o.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){oe(t)}}()}async function Js(t,e){var s;Ge(s=e),s.setTag("units",b.r2.SEPARATOR),s.setTag("separator","-"),await i.data.detectSemanticTypes(t)}function Qs(t){return function(t){function e(t){return t===c[0]?[Pe].concat(m.getMonomerSymbolsByType("PEPTIDE")):t===c[1]?[Pe].concat(m.getMonomerSymbolsByRGroup(3,"PEPTIDE")):["C"]}function s(){"N-Cys"===u.value?(d=e("N-O"),g=e("N-Cys")):(d=e(u.value),g=[...d]),p=n.choiceInput("R1:",d[0],d,(()=>{r.next()})),f=n.choiceInput("R2:",g[0],g,(()=>{r.next()})),r.next(),n.empty(y),[p,f].forEach((t=>{y.appendChild(t.root)}))}const i=new R.Subject,r=new R.Subject;i.subscribe((()=>{a.cyclizationType=u.value,s()})),r.subscribe((()=>{a.rightTerminal=f.value,a.leftTerminal=p.value}));const a={},l=["Cyclization"],h=n.choiceInput("Modification",l[0],l,(()=>a.transformationType=h.value)),c=["N-O","R3-R3","N-Cys"],u=n.choiceInput("Type",c[0],c,(()=>{i.next()})),m=zt.NT.instance.getBioLib();let d=[],g=[],p=n.choiceInput("R1:",d[0],d,(()=>{a.leftTerminal=p.value})),f=n.choiceInput("R2:",g[0],g,(()=>{a.rightTerminal=f.value}));const y=n.divV([p.root,f.root]);s(),a.cyclizationType=u.value,a.leftTerminal=p.value,a.rightTerminal=f.value,a.transformationType=h.value;const b=n.bigButton("Run",(async()=>Ze(t,a))),w=n.div([h,u,y,b]);return new o.Widget(w)}(t)}async function ti(t){const e=(0,z.Xk)(t),s=JSON.stringify(e);o.Utils.download(`${t.name}.json`,s)}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>o});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class n{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class o{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",i="",o="";const r=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)o+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=o+s,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=o+i,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:o+s,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:o+i);const n=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[n][e].parentJ}return new n(s,i,r)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let i=1;i<=this.len1;i++)for(let n=1;n<=this.len2;n++)this.fillOne(i,n),this.dpGrid[i][n].value<=0?(this.dpGrid[i][n].value=0,this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0):0==this.dpGrid[this.dpGrid[i][n].parentI][this.dpGrid[i][n].parentJ].value&&(this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0),this.dpGrid[i][n].value>t&&(t=this.dpGrid[i][n].value,e=i,s=n);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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t,e=this.units===h.r2.HELM?s.get(c,0):this.substructureInput.value;this.units===h.r2.SEPARATOR&&this.separatorInput.value!==this.separator&&""!==this.separatorInput.value&&(e=e.replaceAll(this.separatorInput.value,this.separator)),t=this.units===h.r2.HELM?await d(e,this.col):m(e,this.col),this.col.dataFrame.filter.and(t)})).show()}}function m(t,e,s){const i=s?function(t,e){const s=`${e}`.replace(/[\-\[\]\/\{\}\(\)\*\+\?\.\\\^\$\|]/g,"\\$&"),i=t.charAt(0)===e,n=t.charAt(t.length-1)===e,o=t.replace(new RegExp(`^${s}|${s}$`,"g"),"");return i?n?`${s}${o}${s}`:`${s}${o}${s}|${s}${o}$`:n?`^${o}${s}|${s}${o}${s}`:`^${o}${s}|${s}${o}${s}|${s}${o}$`}(t,s):t,n=o.BitSet.create(e.length);for(let s=0;s<e.length;s++){const o=e.get(s);(o.match(i)||o===t)&&n.set(s,!0,!1)}return n}async function d(t,e){e.version!==e.temp["last-invalidated-version"]&&await g(e,!0);const s=o.Column.string("helm",1).init((e=>t));s.semType=o.SEMTYPE.MACROMOLECULE,s.setTag(o.TAGS.UNITS,h.r2.HELM);const n=await(0,r.D)(s,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:n.get(0),molBlockFailover:""})).get(0)}async function g(t,e){const s=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const i=new Map,n=await(0,r.D)(t,e,i);t.temp["monomeric-mols"]=n,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>r});var i=s(4469),n=s(976),o=s(499);function r(t,e,s=[],r=[],a=!0){const[l,h]=function(t,e,s=[],r=[]){let a=!0,l="";const h=o.Cn.getOrCreate(t);if(t.semType!==n.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;r.length>0&&!r.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==r.length?"any alphabet":`alphabet${r.length>1?"s":""} ${r.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,r);return a&&!l&&i.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>o,WY:()=>h,jB:()=>c,rs:()=>a});var i,n,o,r,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(n||(n={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(t){t.CELL_CHANGING="isCellChanging"}(r||(r={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>m});var i=s(976),n=s(3870),o=s(4469),r=s(3336),a=s.n(r),l=s(8447),h=s(499);let c=null,u=[];function m(t){let e=t??o.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=h.Cn.getOrCreate(e),r=s.notation;const m=n.divText("Current notation: "+r,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),d=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],g=n.columnInput("Column",o.shell.t,e,(t=>{t.semType===i.SEMTYPE.MACROMOLECULE?(e=t,s=h.Cn.getOrCreate(e),r=s.notation,r===l.r2.HELM&&(y.value="/"),m.textContent="Current notation: "+r,f=d.filter((t=>t!==r)),w=n.choiceInput("Convert to",f[0],f,b),b(),c?.clear(),c?.add(n.div([m,g.root,w.root,y.root]))):g.value=e})),p=["-",".","/"];let f=d.filter((t=>t!==r));const y=n.choiceInput("Separator",p[0],p),b=()=>{w.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let w=n.choiceInput("Convert to",f[0],f,b);b(),w.onChanged((()=>{b()})),null==c&&(c=n.dialog("Convert Sequence Notation").add(n.div([m,g.root,w.root,y.root])).onOK((async()=>{const t=w.value,s=y.value??void 0;await async function(t,e,s){const i=h.Cn.getOrCreate(t).convert(e,s);t.dataFrame.columns.add(i);const n=await o.functions.call("Bio:detectMacromolecule",{col:i});return n&&(i.semType=n),await o.data.detectSemanticTypes(t.dataFrame),i}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},5490:(t,e,s)=>{"use strict";s.d(e,{NT:()=>M,cf:()=>S});var i,n=s(4469),o=s(3870),r=s(976),a=s(701);class l{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let s=t;const i=this.isWhitespace(s)?e:e-1;for(let t=0;t<i;t++)s=this.getNextColumnIdx(s);return s}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let s=this.getAtomBlockIdx();for(let i=0;i<t;i++)s=this.shiftIdxToAtomType(s),e[i]=this.parseAtomType(s),s=this.getNextLineIdx(s);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),s=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let n=0;n<this.atomCount;n++){i=this.shiftIdxToXColumn(i);for(const o of[t,e,s])o[n]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:s}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let s=0;s<this.bondCount;s++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[s]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let s=this.getBondBlockIdx();for(let i=0;i<t;i++)s=this.shiftIdxToBondType(s),e[i]=this.parseIntValue(s),s=this.getNextLineIdx(s);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let s=e+1;for(;!this.isWhitespace(s);)++s;return t(this.fileContent.substring(e,s))}}class h extends l{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,s=e;return this.isQuote(e)?(s=this.getNextIdenticalChar(e),e++):s=this.fileContent.indexOf(" ",s),this.fileContent.substring(e,s)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((s=this.fileContent.charCodeAt(e+1))>64&&s<91||s>96&&s<123);var s}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let s=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(s=this.shiftIdxToAtomType(s),t(this.fileContent.charCodeAt(s),s))return!0;s=this.getNextLineIdx(s)}return!1}}!function(t){t.HEADER="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t.RGP_LINE="M RGP",t.A_LINE="A ",t.END="M END"}(i||(i={}));class c extends h{constructor(t){super(t)}static validate(t){return-1!==t.indexOf(i.HEADER)&&-1!==t.indexOf(i.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,i.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<i.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,i.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,i.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+i.NUM_OF_COUNTS_DIGITS;const s=parseInt(this.fileContent.substring(t,e));return t=e,e+=i.NUM_OF_COUNTS_DIGITS,{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class u extends h{constructor(t){super(t),this.init(t)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static validate(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const s=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class m{constructor(){}static getInstance(t){if(c.validate(t))return new c(t);if(u.validate(t))return new u(t);throw new Error("Malformed molfile")}}var d=s(7228),g=s(2904);const p="Libraries",f="System:AppData/Bio/libraries/";async function y(){return await Promise.all((await n.dapi.files.list(f,!0,"")).map((async t=>t.fullPath.substring(f.length))))}let b=Promise.resolve();async function w(){let t;return b=b.then((async()=>{const e=await n.dapi.userDataStorage.getValue(p,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await b,t}async function C(t){b=b.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await n.dapi.userDataStorage.postValue(p,"Settings",JSON.stringify(t),!0)})),await b}async function v(){const t=o.dialog({title:"Manage files"}).add(o.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function S(){const t=o.button("Manage",v),e=o.inputs([]),s=await y(),i=await w();for(const t of s){const s=o.boolInput(t,!i.exclude.includes(t),(()=>{1==s.value?i.exclude=i.exclude.filter((e=>e!=t)):i.exclude.includes(t)||i.exclude.push(t),C(i).then((async()=>{await M.instance.loadLibraries(!0),n.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new r.Widget(o.divV([e,o.div(t)]))}class T{constructor(t,e){this._monomers={},this._onChanged=new a.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}getMonomerSymbolsByRGroup(t,e,s){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let s=e?.rgroups.length>=t;return m.getInstance(e.molfile).atomTypes.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),s&&(s=!0),s})),i.map((t=>t?.symbol)))}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class M{constructor(){this._monomerLib=new T({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([y(),w()]),i=e.filter((t=>!s.exclude.includes(t))),n=await Promise.all(i.map((t=>this.readLibrary(f,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new T({},s)})))));this._monomerLib.updateLibs(n,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;n.shell.warning(e);const s=t instanceof Error?t.stack:void 0;g._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,i,o=[];const a=new r.FileSource(t);if(e.endsWith(".sdf"))1===r.Func.find({package:"Chem",name:"importSdf"}).length?(s=await a.readAsBytes(e),i=await n.functions.call("Chem:importSdf",{bytes:s}),o=(0,d.Xk)(i[0])):n.shell.warning("Chem package is not installed");else if(e.endsWith(".json")){const t=await a.readAsText(e);o=JSON.parse(t)}else{if(!e.endsWith(".csv"))throw new Error("Monomer library of unknown file format, supported formats: SDF, JSON, CSV");{const t=(l=await a.readCsv(e),Array.from({length:l.rowCount},((t,e)=>l.columns.names().reduce(((t,s)=>(t[s]=l.get(s,e),t)),{}))));if(!(0,d.eD)(t))throw new Error("Invalid format of CSV monomer lib");o=(0,d.Z)(t)}}var l;const h={},c=[];return o.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new T(h)}static get instance(){return M._instance||(M._instance=new M),M._instance}}M._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>I});var i=s(4469),n=s(976),o=s(3870),r=s(8447),a=s(499),l=s(6098),h=s(8341),c=s(2568),u=s(3553),m=s(2904),d=s(3379),g=s.n(d),p=s(7795),f=s.n(p),y=s(569),b=s.n(y),w=s(3565),C=s.n(w),v=s(9216),S=s.n(v),T=s(4589),M=s.n(T),A=s(9564),E={};E.styleTagTransform=M(),E.setAttributes=C(),E.insert=b().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),g()(A.Z,E),A.Z&&A.Z.locals&&A.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async function I(t={}){return new Promise((async(e,s)=>{var 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i=["NH2","COOH"];if(t.startsWith(i[0])){const s=i[0].length;(0,x.hu)("-"==t[s],`Wrong sequence format: ${i[0]} without following '-' in '${t}'.`),e=s}if(t.endsWith(i[1])){const e=i[1].length+1;(0,x.hu)("-"==t[s-e],`Wrong sequence format: ${i[1]} without '-' precending in '${t}'.`),s-=e}return t.substring(e,s)}static _dropDefises(t){return t.replace(/(-)([^-]+)/g,"$2")}static clean(t){return N._dropDefises(N._truncateSequence(t))}encode(t){const e=t.length,s=new Array(e).fill(0);for(let i=0;i<e;++i){const e=t[i];(0,x.hu)(e in this.aa2num,`Unknown char '${e}' found in sequence '${t}'`),s[i]=this.encodeLettter(e)}return s}encodeLettter(t){return this.aa2num[t]}decode(t){let e="";for(let s=0;s<t.length;++s){const i=t[s];(0,x.hu)(i in this.num2aa,`Unknown code '${i}' found in vector '${t}'`),e+=this.num2aa[i]}return e}}var L=s(3553);const _="input.fa",R="result.fasta";function O(t){return t.reduce(((t,e,s)=>t+`>sample${s+1}\n${e}\n`),"")}async function k(t,e=!1,s="",o=null,r,a,l){let h=t.toList();e&&(h=h.map((t=>N.clean(t).replace(/\-/g,""))));const c=t.length;o??(o=i.Column.string("Clusters",c).init("0")),o.type!=i.COLUMN_TYPE.STRING&&(o=o.convertTo(i.TYPE.STRING)),o.compact();const u=o.categories,m=o.getRawData(),d=new Array(u.length),g=new Array(u.length);for(let t=0;t<c;++t){const e=m[t];(d[e]??(d[e]=[])).push(h[t]),(g[e]??(g[e]=[])).push(t)}const p=await new E(["base/1.0.0",{tool:"kalign",version:L.WY,reinit:!0}]),f=i.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(d[t]);await p.fs.writeFile(_,e);const s=`${void 0!==r?` --gpo ${r}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,i=await p.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(i);const o=await p.cat(R);if(!o)throw new Error("kalign output no result");const h=new n.i(o).sequencesArray,c=g[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(i.TAGS.UNITS),b=t.getTag("alphabet");return f.setTag(i.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",b),f.semType=i.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var i=s(4469),n=s(976),o=s(8447),r=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const m=await i.dapi.docker.dockerContainers.filter("bio").first();if("started"!==m.status&&"checking"!==m.status)return i.log.warning("PepSeA container has not started yet"),null;const d=t.length;u??(u=n.Column.int("Clusters",d).init(0)),u.type!=n.COLUMN_TYPE.STRING&&(u=u.convertTo(n.TYPE.STRING));const g=u.categories,p=new Array(g.length);for(let e=0;e<d;++e){const s=u.get(e);if(""===s)continue;const i=g.indexOf(s),n=t.get(e);n&&(p[i]??(p[i]=[])).push({ID:e.toString(),HELM:n})}const f=new Array(d);for(const t of p){const e=(await c(m.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(r.rs.SEPARATOR)}const y=n.Column.fromStrings(e,f);return y.setTag(n.TAGS.UNITS,o.r2.SEPARATOR),y.setTag("separator",r.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=n.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,n,o){const r={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${n}&gap_extend=${o}`,l=await i.dapi.docker.dockerContainers.request(t,a,r);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var i=s(976),n=s(3870),o=s(4469),r=s(6414),a=s.n(r),l=s(8447),h=s(499);const c=60;function u(){const t=o.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),r=s?[s.name]:[],u=n.multiChoiceInput("Seq id columns",r,e.map((t=>t.name))),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),g=d.length>0?d[0].name:[],p=n.choiceInput("Seq column",g,d.map((t=>t.name))),f=n.intInput("FASTA line width",c);n.dialog({title:"Save as FASTA"}).add(n.inputs([u,p,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=p.value?t.columns.byName(p.value).column:null,i=f.value??c;s||o.shell.warning("Seq column is mandatory to save as FASTA.");const n=function(t,e,s=c,i="\n"){const n=l.kB,o=[];for(let r=0;r<e.length;r++){const a=t.map((t=>t.get(r).toString())).join("|"),l=m(e.get(r),n,s);o.push(`>${a}${i}`);for(const t of l)o.push(`${t}${i}`)}return"".concat(...o)}(e,s,i),r=document.createElement("a");r.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(n)}`),r.setAttribute("download",`${t.dataFrame.name}.fasta`),r.click()})).show()}function m(t,e,s=c){const i=e(t);let n=0;const o=i.length,r=[];for(;n<o;){const t=a()(i).slice(n,n+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");r.push(e),n+=t.length}return r}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var i=s(4469),n=s(976),o=s(1061),r=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,o.gw)(10),!(0,r.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const i=s.columns.byIndex(t);i.semType=l.Of.MONOMER,i.setTag("alphabet",e.getTag("alphabet"));const n=100;let o=0;for(;h.columns.byName(i.name)&&o<n;)i.name=u(i.name),o++;h.columns.add(i)}await i.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++){const e=s.columns.byIndex(t);e.setTag(n.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>o,Y:()=>r});var i=s(4469),n=s(976);function o(){const t=i.shell.t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);if(null!==t)return t;i.shell.error("Current table does not contain macromolecules")}function r(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>g,OZ:()=>C});var i=s(4469),n=s(3870),o=s(976),r=s(6414),a=s.n(r),l=s(701),h=s(499),c=s(8447),u=s(9298);function m(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?m(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var d,g,p=s(2904);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new o.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},o.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class f{constructor(t=0,e){this.count=t,this.bounds=e}}class y{get label(){return this._label?this._label:this.name}constructor(t,e,s,i){this.pos=t,this.name=e,this._freqs=s??{},i?.rowCount&&(this.rowCount=i.rowCount),i?.sumForHeightCalc&&(this.sumForHeightCalc=i.sumForHeightCalc),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new f),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,i])=>i.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,i,n,r,a,l,h,c){const m=n==u.ES.Entropy?i*(r-this.sumForHeightCalc)/r:i;let d=c*h+(i-m-1);const g=Object.entries(this._freqs).sort(((e,s)=>t(e[0])||t(s[0])?t(e[0])&&t(s[0])?0:t(e[0])?-1:1:s[1].count-e[1].count));for(const t of g){const i=t[1],n=m*i.count/this.rowCount;i.bounds=new o.Rect((e-s)*h*a,d,l*h,n),d+=n}}render(t,e,s,i,n,o){for(const[r,a]of Object.entries(this._freqs))if(!e(r)){const e=(0,c.GU)(r,5),l=a.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=o.get(r)??o.get("other"),t.textAlign="left",t.font=s;const u=t.measureText(e);t.setTransform(l.width/u.width,0,0,l.height/n,h,l.top),t.fillText(e,0,-i)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(g||(g={}));const b=u.vS;var w;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(w||(w={}));class C extends o.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.renderLevelRequested=w.Freqs,this.viewerId=C.viewerCount,C.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(g.sequenceColumnName,b.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(g.startPositionName,b.startPositionName,{category:d.DATA}),this.endPositionName=this.string(g.endPositionName,b.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(g.skipEmptySequences,b.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(g.skipEmptyPositions,b.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(g.shrinkEmptyTail,b.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(g.backgroundColor,b.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(g.positionHeight,b.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(g.positionWidth,b.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(g.verticalAlignment,b.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(g.horizontalAlignment,b.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(g.fixWidth,b.fixWidth,{category:d.LAYOUT,userEditable:!1}),this.fitArea=this.bool(g.fitArea,b.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(g.minHeight,b.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(g.maxHeight,b.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(g.showPositionLabels,b.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(g.positionMarginState,b.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(g.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(g.filterSource,b.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=n.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=n.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){this.setDataInProgress||(this.setDataInProgress=!0,p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.setData() `),this.viewPromise=this.viewPromise.then((async()=>{this.viewed&&(await this.destroyView(),this.viewed=!1)})).then((async()=>{await this.detachPromise,this.updateSeqCol()})).then((async()=>{this.viewed||(await this.buildView(),this.viewed=!0)})).finally((()=>{this.setDataInProgress=!1})))}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=n.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=n.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=n.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,n.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(w.Freqs,"buildView"),p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(w.Layout,"rootOnSizeChanged").then((()=>{}))}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.getFilter(),e=0===t.trueCount?this.unitsHandler.maxLength:a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(".positionNames"),i=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(c.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=i?i.split(c.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(w.Freqs,"updatePositions").then((()=>{}))}getFilter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const n=e>i;if(this.setSliderVisibility(n),n){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,Math.max(this.Length-.001),t,e)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,n=this.root.clientHeight/s,o=Math.max(1,Math.min(i,n));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const r=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*s,l=Math.min(this.root.clientWidth,r);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=r>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,Math.max(0,this.Length-.001),t,e)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case g.sequenceColumnName:this.updateSeqCol();break;case g.sequenceColumnName:case g.startPositionName:case g.endPositionName:case g.filterSource:case g.shrinkEmptyTail:case g.skipEmptyPositions:case g.positionHeight:this.updatePositions();break;case g.minHeight:case g.maxHeight:case g.positionWidth:case g.showPositionLabels:case g.fixWidth:case g.fitArea:case g.horizontalAlignment:case g.verticalAlignment:case g.positionMargin:case g.positionMarginState:this.render(w.Layout,`onPropertyChanged(${t.name})`).then((()=>{}));break;case g.backgroundColor:this.render(w.Render,`onPropertyChanged(${t.name})`).then((()=>{}))}}onTableAttached(){p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){if(this.setDataInProgress)return;p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.detach(), `);const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.viewed&&(await this.destroyView(),this.viewed=!1),t()}))}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),n=this.positions[i];if(void 0===n)return[i,null,null];const o=n.getMonomerAt(s,t.y);return void 0===o?[i,null,null]:[i,o,n.getFreq(o)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>{const e=this.unitsHandler.defaultGapSymbol;return!t.hasMonomer(e)||t.getFreq(e).count!==t.rowCount})).toArray())}render(t,e){p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${t}, reason='${e}' )`);const s=()=>{if(p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new y(this.startPosition+e,t,{},{label:s})}const s=this.getFilter(),i=this.dataFrame.rowCount,n=this.unitsHandler.splitted;for(let e=0;e<i;++e)if(s.get(e)){const s=n[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||this.unitsHandler.defaultGapSymbol;this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()},n=(t,e)=>{p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const s=this.canvas.height-e*t,n=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==n&&i.shell.error("WebLogo: alphabet is undefined.");const o=Math.log2(n);for(let i=Math.floor(this.slider.min);i<=Math.floor(this.slider.max);++i)i in this.positions?this.positions[i].calcScreen((t=>this.unitsHandler.isGap(t)),i,this.slider.min,s,this.positionHeight,o,this._positionWidthWithMargin,this._positionWidth,t,e):console.warn(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()},r=t=>{if(p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,i=this.showPositionLabels?12:0;if(t>=w.Freqs&&s(),this.calcLayout(e),0===this.positions.length||-1===this.startPosition||-1===this.endPosition)return;t>=w.Layout&&n(window.devicePixelRatio,i);const r=this.canvas.getContext("2d");if(!r)return;this.Length,r.resetTransform(),r.fillStyle=function(t){const e=o.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),r.fillRect(0,0,this.canvas.width,this.canvas.height),r.textBaseline=this.textBaseline;const a=10*e;r.resetTransform(),r.fillStyle="black",r.textAlign="center",r.font=`${a.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const l=Math.max(...this.positions.map((t=>r.measureText(t.name).width))),h=l<this._positionWidth*e-2?1:(this._positionWidth*e-2)/l;i>0&&function(t,e,s,i,n,o,r,a){for(let l=Math.floor(r);l<=Math.floor(a);l++){const a=o[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-r)*i*e+n*e/2,0),t.fillText(a.label,0,1)}}(r,e,h,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(r,(t=>this.unitsHandler.isGap(t)),"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)};return this.renderLevelRequested=Math.max(this.renderLevelRequested,t),new Promise(((t,e)=>{window.setTimeout((()=>{try{if(this.renderLevelRequested>w.None)try{r(this.renderLevelRequested)}finally{this.renderLevelRequested=w.None}}catch(t){e(t)}}),0)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(w.Layout,"sliderOnValuesChanged").then((()=>{}))}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(w.Freqs,"dataFrameFilterOnChanged").then((()=>{}))}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){p._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===u.Ct.Selected&&this.render(w.Freqs,"dataFrameSelectionOnChanged").then((()=>{}))}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,i=this.canvas.getCursorPosition(s,e),[o,r]=this.getMonomer(i,e);if(this.dataFrame&&this.seqCol&&r){const t=this.positions[o],e=function(t,e,s,i,n){let o=0,r=-1;for(;-1!=(r=s.findNext(r,!0));){const t=e.splitted[r],s=n.pos;(s<t.length?t[s]:null)===i&&o++}return o}(this.dataFrame,this.unitsHandler,this.getFilter(),r,t),i=n.div([n.div(`${r}`),n.div(`${e} rows`)]);n.tooltip.show(i,s.x+16,s.y+16)}else n.tooltip.hide()}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[i,n]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&n){const t=this.positions[i],e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,i,n,o){const r=e.splitted[i],a=o.pos<r.length?r[o.pos]:null;return a===n||""===a&&n===e.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.getFilter(),e,n,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=m(t);p._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+e)}}}C.residuesSet="nucleotides",C.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>g});var i=s(3870),n=s(976),o=s(4469),r=s(6414),a=s.n(r),l=s(7983),h=s(701),c=s(4293),u=s(8447),m=s(1061);const d=rxjs.operators;class g extends n.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(n.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(n.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new b,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged())),this.subs.push(o.events.onResetFilterRequest.subscribe((t=>{this.bioFilter?.resetFilter()})))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class p{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substructureSearch(t){return null}}class f extends p{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,l.pf)(this.substructure,t)}resetFilter(){this.substructureInput.value=""}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,l.pf)(this.substructure,t,this.colSeparator)}}class b extends p{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await o.functions.call("HELM:helmWebEditor"),await i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substructureSearch(t){i.setUpdateIndicator(this._filterPanel,!0),await(0,m.gw)(10);const e=await(0,l.QF)(this.substructure,t);return i.setUpdateIndicator(this._filterPanel,!1),e}resetFilter(){console.debug("Bio: HelmFilter.resetFilter()"),this.helmSubstructure="",this.updateFilterPanel(this.substructure)}}},3336:t=>{"use strict";t.exports=$},976:t=>{"use strict";t.exports=DG},4469:t=>{"use strict";t.exports=grok},701:t=>{"use strict";t.exports=rxjs},3870:t=>{"use strict";t.exports=ui},6414:t=>{"use strict";t.exports=wu}},e={};function s(i){var n=e[i];if(void 0!==n)return n.exports;var o=e[i]={id:i,exports:{}};return t[i].call(o.exports,o,o.exports,s),o.exports}s.m=t,s.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return s.d(e,{a:e}),e},s.d=(t,e)=>{for(var i in e)s.o(e,i)&&!s.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},s.u=t=>t+".js",s.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),s.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),s.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;s.g.importScripts&&(t=s.g.location+"");var e=s.g.document;if(!t&&e&&(e.currentScript&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var n=i.length-1;n>-1&&!t;)t=i[n--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),s.p=t})(),s.b=document.baseURI||self.location.href,s.nc=void 0;var i=s(2904);bio=i})();
2
+ var bio;(()=>{var t={2012:(t,e,s)=>{"use strict";s.d(e,{f:()=>n});var i=s(9976);class n extends i.B{static get Lesk(){return void 0===this.lesk&&(this.lesk=this.makePalette([[["G","A","S","T"],"orange"],[["C","V","I","L","P","F","Y","M","W"],"all_green"],[["N","Q","H"],"magenta"],[["D","E"],"red"],[["K","R"],"all_blue"]],!1,n)),this.lesk}static get GrokGroups(){return void 0===this.grokGroups&&(this.grokGroups=this.makePalette([[["C","U"],"yellow"],[["G","P"],"red"],[["A","V","I","L","M","F","Y","W"],"all_green"],[["R","H","K"],"light_blue"],[["D","E"],"dark_blue"],[["S","T","N","Q"],"orange"]],!1,n)),this.grokGroups}static get RasMol(){return void 0===this.rasMol&&(this.rasMol=new n({D:"#E60A0A",E:"#E60A0A",C:"#E6E600",M:"#E6E600",K:"#145AFF",R:"#145AFF",S:"#FA9600",T:"#FA9600",F:"#3232AA",Y:"#3232AA",N:"#00DCDC",Q:"#00DCDC",G:"#EBEBEB",L:"#0F820F",V:"#0F820F",I:"#0F820F",A:"#C8C8C8",W:"#B45AB4",H:"#8282D2",P:"#DC9682",others:"#BEA06E"})),this.rasMol}get(t){const e=t in n.aaSynonyms?n.aaSynonyms[t]:t;return super.get(e)}}n.aaSynonyms={MeNle:"L",MeA:"A",MeG:"G",MeF:"F"};class o{static getPalette(t="grok"){switch(t){case"grok":return n.GrokGroups;case"lesk":return n.Lesk;default:throw new Error(`ChemPalette: scheme \`${t}\` does not exist`)}}static getInnerOuter(t){let e=0,s="",i="";for(const n of t)"("==n?e++:")"==n?e--:e?s+=n:i+=n;return isNaN(parseInt(s))?[i,s]:[i,""]}static getColorAAPivot(t="",e="grok"){const s=this.getPalette(e);let[i,n]=this.getInnerOuter(t);if(i=i.length>6?`${i.slice(0,3)}...`:i,n=n.length>6?`${n.slice(0,3)}...`:n,1==t.length||"("==t[1]){const e=t[0]?.toUpperCase();return e in s?[s.get(e),e,n,1]:[this.undefinedColor,i,n,1]}if("d"==t[0]&&t[1]in s&&(2==t.length||"("==t[2])){const e=t[1]?.toUpperCase();return e in s?[s.get(e),e,n,2]:[this.undefinedColor,i,n,2]}if(t.substring(0,3)in this.AAFullNames&&(3==t.length||"("==t[3])){const e=this.AAFullNames[t.substring(0,3)];return e in s?[s.get(e),e,n,3]:[this.undefinedColor,i,n,3]}if(t[0]?.toLowerCase()==t[0]&&t.substring(1,3)in this.AAFullNames&&(4==t.length||"("==t[4])){const e=this.AAFullNames[t.substring(1,3)];return e in s?[s.get(e),e,n,4]:[this.undefinedColor,i,n,4]}return[this.undefinedColor,i,n,0]}}o.SemType="Aminoacids",o.SemTypeMultipleAlignment="AminoacidsMultipleAlignment",o.undefinedColor="rgb(100,100,100)",o.Names={G:"Glycine",L:"Leucine",Y:"Tyrosine",S:"Serine",E:"Glutamic acid",Q:"Glutamine",D:"Aspartic acid",N:"Asparagine",F:"Phenylalanine",A:"Alanine",K:"Lysine",R:"Arginine",H:"Histidine",C:"Cysteine",V:"Valine",P:"Proline",W:"Tryptophan",I:"Isoleucine",M:"Methionine",T:"Threonine"},o.AASmiles={G:"NCC(=O)O",L:"N[C@H](CC(C)C)C(=O)O",Y:"NC(CC1=CC=C(O)C=C1)C(=O)O",S:"NC(CO)C(=O)O",E:"N[C@@H](CCC(O)=O)C(=O)O",Q:"N[C@@H](CCC(N)=O)C(=O)O",D:"N[C@@H](CC(O)=O)C(=O)O",N:"N[C@@H](CC(N)=O)C(=O)O",F:"NC(CC1=CC=CC=C1)C(=O)O",A:"N[C@H](C)C(=O)O",K:"NC(CCCCN)C(=O)O",R:"N[C@H](CCCNC(=N)C)C(=O)O",H:"NC(CC1=CN=C[N]1)C(=O)O",C:"N[C@@H](CS)C(=O)O",V:"NC(C(C)C)C(=O)O",P:"N(CCC1)C1C(=O)O",W:"N[C@@H](Cc1c2ccccc2n([H])c1)C(=O)O",I:"N[C@H]([C@H](C)CC)C(=O)O",M:"NC(CCSC)C(=O)O",T:"NC(C(O)C)C(=O)O"},o.AASmilesTruncated={G:"*C*",L:"CC(C)C[C@H](*)*",Y:"C1=CC(=CC=C1CC(*)*)O",S:"OCC(*)C*",E:"*[C@@H](CCC(O)=O)*",Q:"*N[C@@H](CCC(N)=O)*",D:"*[C@@H](CC(O)=O)*",N:"*[C@@H](CC(N)=O)*",F:"C1=CC=C(C=C1)CC(*)*",A:"C[C@H](*)*",K:"C(CCN)CC(*)*",R:"*[C@H](CCCNC(=N)C)*",H:"C1=C(NC=N1)CC(*)*",C:"C([C@@H](*)*)S",V:"CC(C)C(*)*",P:"C1CCN(*)C1*",W:"*[C@@H](Cc1c2ccccc2n([H])c1)*",I:"CC[C@H](C)[C@H](*)*",M:"CSCCC(*)*",T:"CC(O)C(*)*"},o.AAFullNames={Ala:"A",Arg:"R",Asn:"N",Asp:"D",Cys:"C",Gln:"Q",Glu:"E",Gly:"G",His:"H",Ile:"I",Leu:"L",Lys:"K",Met:"M",Phe:"F",Pro:"P",Ser:"S",Thr:"T",Trp:"W",Tyr:"Y",Val:"V"}},7228:(t,e,s)=>{"use strict";s.d(e,{JN:()=>c,PF:()=>m,Qx:()=>u,Xk:()=>h,Z:()=>l,eD:()=>a});var i=s(976),n=s(4469),o=s(1047),r=(s(499),s(8457));function a(t){return t.every((t=>"object"==typeof t&&Object.values(o.pn).every((e=>e in t&&"string"==typeof t[e]))))}function l(t){function e(t){const e=new RegExp("\\[r\\]","g");let s=0;return t.replace(e,(t=>(++s,`[${s}*]`)))}const s=[];return t.forEach((t=>{const n={...o.zh};Object.entries(o.pn).forEach((([e,s])=>{const i=t[s];n[e]=i}));let r="smiles";const a=t[o.pn[r]],l=e(a).replace("[1*]","[H:1]").replace("[2*]","[OH:2]");n[r]=l,r="rgroups",n[r]=o.Ei,r="molfile";const h=e(a),c=i.chem.convert(h,i.chem.Notation.Smiles,i.chem.Notation.MolBlock);n[r]=c.replace("M ISO","M RGP"),s.push(n)})),console.log("resultLib:",s),s}function h(t){const e=[];for(let s=0;s<t.rowCount;s++){const i={};Object.keys(o.K4).forEach((e=>{if("symbol"===e){const n=t.get(o.K4[e],s);i[e]="."===n?t.get(o.At,s):n}else if("rgroups"===e){const 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p=i.Column.fromStrings("smiles",d.map((t=>s.getMonomer("PEPTIDE",t)?.smiles??""))),f=(i.DataFrame.fromColumns([p]),(await n.chem.getSimilarities(p,c)).getRawData());for(let t=0;t<a;++t){const e=m[t];l[t]+=""!==h&&e!==g?f[e]:""===h&&e===g?1:0}}for(let s=0;s<l.length;++s){let n=l[s]/e.length;for(let r=0;r<t.length;++r){const t=o[r];if(r>=e.length&&t.data[s]!==t.emptyIndex||t.data[s]===t.emptyIndex&&r<e.length){n=i.FLOAT_NULL;break}}l[s]=n}return i.Column.fromFloat32Array("Similarity",l)}async function m(t){const e=(await c()).getBioLib(),s=[],o={},r=t.map((t=>e.getMonomer("PEPTIDE",t)?.smiles??"")),a=i.Column.fromStrings("smiles",r);for(let e=0;e<r.length;++e){o[t[e]]=e;const i=r[e],l=""===i?new Array(r.length).fill(0):(await n.chem.getSimilarities(a,i)).getRawData();l[e]=1,s[e]=Array.from(l)}return{scoringMatrix:s,alphabetIndexes:o}}},8601:(t,e,s)=>{"use strict";s.d(e,{i0:()=>m});var i=s(4469),n=s(976),o=s(6414),r=s.n(o),a=s(1821),l=s(499);const h={V2K_RGP_SHIFT:8,V2K_RGP_LINE:"M 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${n.SEMTYPE.MACROMOLECULE} columns can be converted to atomic level, the chosen column has semType '${e.semType}'`]};let u=e;const m=l.Cn.getOrCreate(e);m.isHelm()&&(u=m.convert(a.r2.SEPARATOR,"."),u.name=e.name);const g=l.Cn.getOrCreate(u).alphabet;let p;if("PT"===g||"UN"===g)p="PEPTIDE";else{if("RNA"!==g&&"DNA"!==g)return{col:null,warnings:[`Unexpected column's '${u.name}' alphabet '${g}'.`]};p="RNA"}const f=function(t){const e=t.length,s=new Array(e),i=l.Cn.getOrCreate(t).getSplitter();for(let n=0;n<e;++n){const e=t.get(n);s[n]=e?r()(i(e)).filter((t=>""!==t)).toArray():[]}return s}(u),y=await async function(t,e,s,n){const o=function(t,e,s){const i=new Map;for(const n of t.getMonomerSymbolsByType(e)){const o=t.getMonomer(e,n);if("RNA"===e&&("Branch"===o.monomerType||"DNA"===s&&o.symbol===h.DEOXYRIBOSE||"RNA"===s&&o.symbol===h.RIBOSE||o.symbol===h.PHOSPHATE)||"PEPTIDE"===e&&"Branch"!==o.monomerType){const t={};c.rx.forEach((e=>{t[e]=o[e]})),i.set(o.symbol,t)}}return i}(e,s,n),r=new Map,a=await i.functions.call("Chem:getRdKitModule"),l={value:null};if("RNA"===s){const t="RNA"===n?[h.RIBOSE,h.PHOSPHATE]:[h.DEOXYRIBOSE,h.PHOSPHATE];for(const e of t)d(r,e,o,a,s,l)}for(let e=0;e<t.length;++e){const i=t[e];for(const t of i)if(""!==t)try{d(r,t,o,a,s,l)}catch(e){const s=e instanceof Error?e.message:e.toString(),i=e instanceof Error?e.stack:void 0;throw console.error(`bio lib: getMonomersDictFromLib() sym='${t}', error:\n${s}\n${i}`),new Error(`Can't get monomer '${t}' from library: ${s}`)}}return r}(f,o,p,g),b=u.length,{molfileList:w,molfileWarningList:C}=await async function(t,e,i,n,o){const r=Math.max(navigator.hardwareConcurrency-2,1),a=new Array(r).fill(null).map((()=>new Worker(new URL(s.p+s.u(79),s.b)))),l=o/r;let h=[],c=[];const u=new Array(r);for(let s=0;s<r;s++){const h=Math.floor(s*l),c=s===r-1?o:Math.floor((s+1)*l);a[s].postMessage({monomerSequencesArray:t,monomersDict:e,alphabet:i,polymerType:n,start:h,end:c}),u[s]=new Promise((t=>{a[s].onmessage=({data:{molfileList:e,molfileWarningList:s}})=>{t({molfileList:e,molfileWarningList:s})}}))}return(await Promise.all(u)).forEach((t=>{h=h.concat(...t.molfileList),c=c.concat(...t.molfileWarningList)})),setTimeout((()=>{a.forEach((t=>{t.terminate()}))}),0),{molfileList:h,molfileWarningList:c}}(f,y,g,p,b);if(C.length>.05*b)throw new Error("Too many errors getting molfiles.");const v=`molfile(${u.name})`,S=t.columns.getUnusedName(v),T=n.Column.fromStrings(S,w);return T.semType=n.SEMTYPE.MOLECULE,T.setTag(n.TAGS.UNITS,n.UNITS.Molecule.MOLBLOCK),{col:T,warnings:C}}function d(t,e,s,i,n,o){if(!t.has(e)){const r=function(t,e,s,i,n){if(e.has(t)){const o=e.get(t),r=function(t){const e=[];for(const s of t){let t=s.capGroupSmiles;t||(t=s.capGroupSMILES),t=t.replace(/(\[|\]|\*|:|\d)/g,""),e.push(t)}return e}(o.rgroups),a=function(t){const e=new Map;let s=t.indexOf(h.V2K_A_LINE,0),i=s;for(;-1!==s;){i=t.indexOf("\n",s);const 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",r)),e[s]=parseInt(t.slice(r,a));s[l]=e[0],i[l]=e.slice(1);const c=t.indexOf("\n",r);let u=t.slice(a,c),m=u.indexOf(h.V3K_BOND_CONFIG);if(-1!==m){m=u.indexOf("=",m)+1;let t=u.indexOf(" ",m);-1===t&&(t=u.length);const e=parseInt(u.slice(m,t));n.set(l,e);const s=h.V3K_BOND_CONFIG+e.toString();u=u.replace(s,"")}u||o.set(l,u)}return{bondTypes:s,atomPairs:i,bondConfiguration:n,kwargs:o}}(l,c.bondCount),y={atoms:m,bonds:d,meta:g(m,d,r,a)};return"PEPTIDE"===i?function(t){const e=t.meta.terminalNodes[0]-1,s=t.meta.rNodes[0]-1,i=t.atoms.x,n=t.atoms.y;T(t,-i[e],-n[e]);const o=C(i[s],n[s]);v(t.atoms,-o),i[t.meta.rNodes[1]-1]<0&&function(t){S(t,!1)}(t);const r=function(t){const e=function(t){const e=new Map;for(const s of t.bonds.atomPairs)for(let t=0;t<2;t++){const i=s[t],n=s[(t+1)%2];e.has(i)?e.get(i)?.push(n):e.set(i,new Array(1).fill(n))}return e}(t);let s=0,i=0;for(;0===s;){const n=e.get(t.meta.terminalNodes[1])[i];t.atoms.atomTypes[n-1]===h.OXYGEN&&n!==t.meta.rNodes[1]&&(s=n),i++}return 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";return i?n.substring(0,e-1)+"…":n}function M(t,e,s="-"){const i=e.map((e=>{const i=function(t,e,s="-"){const i=new Set([...new Set(Object.keys(t)),...e]);i.delete(s);const n=[],o=[];for(const s of i)n.push(s in t?t[s]:0),o.push(e.has(s)?1:0);const r=new h.OW(n),a=new h.OW(o);return(0,c.MA)(r,a)/((0,c.$G)(r)*(0,c.$G)(a))}(t,e.alphabet,s);return new r.d(e,t,i)}));let n;const o=Math.max(...i.map((t=>t.similarity>t.cutoff?t.similarity:-1)));return n=o>0?i.find((t=>t.similarity===o)).name:"UN",n}function A(t,e=5){let s;if(t.semType==i.SEMTYPE.MACROMOLECULE)s=l.Cn.getOrCreate(t).alphabet;else{const i=function(t,e,s){return t.categories,function(t,e){const s={};let i=!0,n=null;for(const o of t)if(null==n?n=o.length:o.length!==n&&(i=!1),o.length>=e)for(const t of o)t in s||(s[t]=0),s[t]+=1;return{freq:s,sameLength:i}}(o()(t.getRawData()).map((e=>s(t.categories[e]))),e)}(t,e,g);s=M(i.freq,a.XS)}return E(s)}function E(t){switch(t){case"PT":return u.f.GrokGroups;case"DNA":case"RNA":return m.J.Chromatogram;default:return d.UE.Color}}function x(t){const e=t.columns.bySemTypeAll(i.SEMTYPE.MACROMOLECULE);let s=e.find((t=>{const e=t.getTag(i.TAGS.UNITS);return!!e&&-1!==e.indexOf("MSA")}))??null;return!s&&e.length>0&&(s=e[0]),s}},8457:(t,e,s)=>{"use strict";s.d(e,{O:()=>a});var i=s(976),n=s(6414),o=s.n(n),r=s(585);function a(t){const e=(0,r.Mj)(t),s=t=>{const e=l.columns.addNewString((t+1).toString());return n.push(e),e},n=[],a=t.length,l=i.DataFrame.create(a);for(let i=0;i<a;++i){const r=t.get(i);if(null==r)continue;const a=e(r);for(const[t,e]of o().enumerate(a))((n[e]??null)||s(e)).set(i,t||"-",!1)}return l}},499:(t,e,s)=>{"use strict";s.d(e,{Cn:()=>d});var i=s(976),n=s(6414),o=s.n(n),r=s(8447),a=s(585),l=s(489),h=s(7228),c=s(1047);const u=new class{constructor(){this.uhTemp=`units-handler.${i.SEMTYPE.MACROMOLECULE}`}},m={[r.r2.FASTA]:"-",[r.r2.SEPARATOR]:"",[r.r2.HELM]:"*"};class d{static setUnitsToFastaColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==r.r2.FASTA)throw new Error(`The column of notation '${r.r2.FASTA}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);t.column.setTag(i.TAGS.UNITS,r.r2.FASTA),d.setTags(t)}static setUnitsToSeparatorColumn(t,e){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE||t.column.getTag(i.TAGS.UNITS)!==r.r2.SEPARATOR)throw new Error(`The column of notation '${r.r2.SEPARATOR}' must be '${i.SEMTYPE.MACROMOLECULE}'.`);if(!e)throw new Error(`The column of notation '${r.r2.SEPARATOR}' must have the separator tag.`);t.column.setTag(i.TAGS.UNITS,r.r2.SEPARATOR),t.column.setTag("separator",e),d.setTags(t)}static setUnitsToHelmColumn(t){if(t.column.semType!==i.SEMTYPE.MACROMOLECULE)throw new Error(`The column of notation '${r.r2.HELM}' must be '${i.SEMTYPE.MACROMOLECULE}'`);t.column.setTag(i.TAGS.UNITS,r.r2.HELM),d.setTags(t)}static setTags(t){const e=t.column.getTag(i.TAGS.UNITS),s=t.stats;if(Object.keys(s.freq).some((t=>t.length>1)),[r.r2.FASTA,r.r2.SEPARATOR].includes(e)){if(0===Object.keys(s.freq).length)throw new Error("Alphabet is empty");let e=t.column.getTag("aligned");null===e&&(e=s.sameLength?"SEQ.MSA":"SEQ",t.column.setTag("aligned",e));let i=t.column.getTag("alphabet");if(null===i&&(i=(0,a.w4)(s.freq,r.XS),t.column.setTag("alphabet",i)),"UN"===i){const e=Object.keys(s.freq).length,i=Object.keys(s.freq).some((t=>t.length>1));t.column.setTag(".alphabetSize",e.toString()),t.column.setTag(".alphabetIsMultichar",i?"true":"false")}}}get column(){return this._column}get units(){return this._units}get notation(){return this._notation}get defaultGapSymbol(){return this._defaultGapSymbol}get separator(){const t=this.column.getTag("separator")??void 0;if(this.notation===r.r2.SEPARATOR&&void 0===t)throw new Error(`Separator is mandatory for column '${this.column.name}' of notation '${this.notation}'.`);return t}get aligned(){const t=this.column.getTag("aligned");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag aligned not set");return t}get alphabet(){const t=this.column.getTag("alphabet");if(!t&&(this.isFasta()||this.isSeparator()))throw new Error("Tag alphabet not set");return t}get helmCompatible(){return this.column.getTag(".isHelmCompatible")}getAlphabetSize(){if(this.notation==r.r2.HELM||"UN"==this.alphabet){const t=this.column.getTag(".alphabetSize");let e;if(t)e=parseInt(t);else{const t=this.stats;e=Object.keys(t.freq).length}return e}switch(this.alphabet){case"PT":return 20;case"DNA":case"RNA":return 4;case"NT":return console.warn("Unexpected alphabet 'NT'."),4;default:throw new Error(`Unexpected alphabet '${this.alphabet}'.`)}}getAlphabetIsMultichar(){return this.notation===r.r2.HELM||"UN"===this.alphabet&&"true"===this.column.getTag(".alphabetIsMultichar")}get splitted(){if(null===this._splitted){const t=this.getSplitter(),e=this._column.length;this._splitted=new Array(e);const s=this._column.getRawData(),i=this._column.categories;for(let n=0;n<e;n++){const e=i[s[n]];this._splitted[n]=t(e)}}return this._splitted}get stats(){if(null===this._stats){const t={};let e=!0,s=null;for(const i of this.splitted){null==s?s=i.length:i.length!==s&&(e=!1);for(const e of i)e in t||(t[e]=0),t[e]+=1}this._stats={freq:t,sameLength:e}}return this._stats}get maxLength(){return null===this._maxLength&&(this._maxLength=Math.max(...this.splitted.map((t=>t.length)))),this._maxLength}get posList(){if(null===this._posList){const t=this.column.getTag(".positionNames");this._posList=t?t.split(r.CI).map((t=>t.trim())):o().count(1).take(this.maxLength).map((t=>t.toString())).toArray()}return this._posList}isFasta(){return this.notation===r.r2.FASTA}isSeparator(){return this.notation===r.r2.SEPARATOR}isHelm(){return this.notation===r.r2.HELM}isRna(){return"RNA"===this.alphabet}isDna(){return"DNA"===this.alphabet}isPeptide(){return"PT"===this.alphabet}isMsa(){return!!this.aligned&&this.aligned.toUpperCase().includes("MSA")}isHelmCompatible(){return"true"===this.helmCompatible}isGap(t){return!t||this.units===r.r2.FASTA&&t===m[r.r2.FASTA]||this.units===r.r2.HELM&&t===m[r.r2.HELM]}getNotation(){if(this.units.toLowerCase().startsWith(r.r2.FASTA))return r.r2.FASTA;if(this.units.toLowerCase().startsWith(r.r2.SEPARATOR))return r.r2.SEPARATOR;if(this.units.toLowerCase().startsWith(r.r2.HELM))return r.r2.HELM;throw new Error(`Column '${this.column.name}' has unexpected notation '${this.units}'.`)}getHelmWrappers(){return[this.isDna()||this.isRna()||this.isHelmCompatible()?"RNA1{":"PEPTIDE1{",this.isDna()?"d(":this.isRna()?"r(":"",this.isDna()||this.isRna()?")p":"","}$$$$"]}getNewColumn(t,e){const s=this.column,n=s.length,o=t.toLowerCase()+"("+s.name+")",a=s.dataFrame.columns.getUnusedName(o),l=i.Column.fromList("string",a,new Array(n).fill(""));if(l.semType=i.SEMTYPE.MACROMOLECULE,l.setTag(i.TAGS.UNITS,t),t===r.r2.SEPARATOR){if(!e)throw new Error(`Notation '${r.r2.SEPARATOR}' requires separator value.`);l.setTag("separator",e)}l.setTag(i.TAGS.CELL_RENDERER,"Macromolecule");const h=s.getTag("aligned");h&&l.setTag("aligned",h);const c=s.getTag("alphabet");null!=c&&l.setTag("alphabet",c);let u=s.getTag(".alphabetSize");null!=c&&u&&l.setTag(".alphabetSize",u);const m=s.getTag(".alphabetIsMultichar");return null!=c&&void 0!==m&&l.setTag(".alphabetIsMultichar",m),t==r.r2.HELM&&(u=this.getAlphabetSize().toString(),l.setTag(".alphabetSize",u)),l}static getNewColumn(t){const e=d.getOrCreate(t),s=e.notation;return e.getNewColumn(s)}static unitsStringIsValid(t){return t=t.toLowerCase(),[r.r2.FASTA,r.r2.SEPARATOR,r.r2.HELM].some((e=>t.startsWith(e.toLowerCase())))}static getNewColumnFromParams(t,e,s){if(!d.unitsStringIsValid(s))throw new Error("Invalid format of 'units' parameter");const n=i.Column.fromList("string",e,new Array(t).fill(""));return n.semType=i.SEMTYPE.MACROMOLECULE,n.setTag(i.TAGS.UNITS,s),n}getSplitter(t){if(this.units.toLowerCase().startsWith(r.r2.FASTA))return null===this.column.getTag("alphabet")||this.getAlphabetIsMultichar()?a.kB:a.FJ;if(this.units.toLowerCase().startsWith(r.r2.SEPARATOR))return(0,a.Ar)(this.separator,t);if(this.units.toLowerCase().startsWith(r.r2.HELM))return a.gP;throw new Error(`Unexpected units ${this.units} .`)}getDistanceFunctionName(){if(!this.isFasta())throw new Error("Only FASTA notation is supported");return this.isMsa()?l.U.HAMMING:(this.alphabet,l.U.LEVENSHTEIN)}getDistanceFunction(){return l.o[this.getDistanceFunctionName()]()}async checkHelmCompatibility(){if(this.column.tags.has(".isHelmCompatible"))return"true"===this.column.getTag(".isHelmCompatible");const t=(await(0,h.JN)()).getBioLib().getMonomerSymbolsByType("PEPTIDE".toString()),e=new Set(t),s=(0,a.Ar)(this.separator);for(const t of this.column.categories){const i=s(t);for(const t of i)if(!e.has(t))return this.column.setTag(".isHelmCompatible","false"),!1}return this.column.setTag(".isHelmCompatible","true"),!0}get splitter(){return null===this._splitter&&(this._splitter=(0,a.Mj)(this.column)),this._splitter}toFasta(t){return t===r.r2.FASTA}toSeparator(t){return t===r.r2.SEPARATOR}toHelm(t){return t===r.r2.HELM}convertHelmToFastaSeparator(t,e,s,i){i||(i=this.toFasta(e)?m[r.r2.FASTA]:m[r.r2.SEPARATOR]),s||(s=this.toFasta(e)?"":this.separator);const n=t.startsWith("RNA"),o=this.splitter(t),a=[];for(let t=0;t<o.length;t++){let s=o[t];if(n&&(s=s.replace(c.pU,"")),s===m[r.r2.HELM])a.push(i);else if(this.toFasta(e)&&s.length>1){const t="["+s+"]";a.push(t)}else a.push(s)}return a.join(s)}convert(t,e){const s=this.getConverter(t,e),i=this.getNewColumn(t,e);return i.init((t=>s(this.column.get(t)))),i}getRegion(t,e,s){const i=this.getNewColumn(this.notation,this.separator);i.name=s,Math.max(...this.splitted.map((t=>t.length)));const n=t??0,o=e??this.maxLength-1,a=this.getJoiner(),l=o-n+1;i.init((t=>{const e=this.splitted[t],s=new Array(l);for(let t=0;t<l;++t){const i=n+t;s[t]=i<e.length?e[i]:m[this.notation]}return a(s)}));const h=t=>{const e=t.split(",").map((t=>t.trim())),s=new Array(l);for(let t=0;t<l;++t){const i=n+t;s[t]=i<e.length?e[i]:"?"}return s.join(r.CI)},c=this.column.getTag(".positionNames");c&&i.setTag(".positionNames",h(c));const u=this.column.getTag(".positionLabels");return u&&i.setTag(".positionLabels",h(u)),i}getJoiner(){const t=this;if(this.notation===r.r2.FASTA)return function(e){return g(t,e)};if(this.notation===r.r2.SEPARATOR)return function(e){return p(t,e,t.separator)};if(this.notation===r.r2.HELM){const e="DNA"===t.alphabet||"RNA"===t.alphabet;return function(s){return f(t,s,e)}}throw new Error}getConverter(t,e=undefined){if(t===r.r2.SEPARATOR&&!e)throw new Error(`Target separator is not specified for target units '${r.r2.SEPARATOR}'.`);const s=this;if(t===r.r2.FASTA)return function(t){return function(t,e){const s=t.isHelm()?y(t,e):t.getSplitter()(e);return g(t,s)}(s,t)};if(t===r.r2.HELM)return function(t){return function(t,e){const s=e.startsWith("DNA")||e.startsWith("RNA"),i=t.getSplitter()(e);return f(t,i,s)}(s,t)};if(t===r.r2.SEPARATOR)return function(t){return function(t,e,s){const i=t.isHelm()?y(t,e):t.getSplitter()(e);return p(t,i,s)}(s,t,e)};throw new Error}constructor(t){if(this._splitter=null,this._splitted=null,this._stats=null,this._maxLength=null,this._posList=null,t.type!=i.TYPE.STRING)throw new Error(`Unexpected column type '${t.type}', must be '${i.TYPE.STRING}'.`);this._column=t;const e=this._column.getTag(i.TAGS.UNITS);if(null==e)throw new Error("Units are not specified in column");if(this._units=e,this._notation=this.getNotation(),this._defaultGapSymbol=this.isFasta()?m[r.r2.FASTA]:this.isHelm()?m[r.r2.HELM]:m[r.r2.SEPARATOR],!this.column.tags.has("aligned")||!this.column.tags.has("alphabet")||!this.column.tags.has(".alphabetIsMultichar")&&!this.isHelm()&&"UN"===this.alphabet)if(this.isFasta())d.setUnitsToFastaColumn(this);else if(this.isSeparator()){const e=t.getTag("separator");d.setUnitsToSeparatorColumn(this,e)}else{if(!this.isHelm())throw new Error(`Unexpected units '${this.column.getTag(i.TAGS.UNITS)}'.`);d.setUnitsToHelmColumn(this)}if(!this.column.tags.has(".alphabetIsMultichar"))if(this.isHelm())this.column.setTag(".alphabetIsMultichar","true");else if(["UN"].includes(this.alphabet))throw new Error(`For column '${this.column.name}' of alphabet '${this.alphabet}' tag '.alphabetIsMultichar' is mandatory.`)}static getOrCreate(t){return u.uhTemp in t.temp||(t.temp[u.uhTemp]=new d(t)),t.temp[u.uhTemp]}}function g(t,e){const s=new Array(e.length);for(const[i,n]of o().enumerate(e)){let o=i;t.isHelm()&&(o=i.replace(c.pU,"$1")),t.isGap(o)?o=m[r.r2.FASTA]:o.length>1&&(o="["+e[n]+"]"),s[n]=o}return s.join("")}function p(t,e,s){const i=new Array(e.length);for(const[s,n]of o().enumerate(e)){let e=s;t.isGap(e)&&(e=m[r.r2.SEPARATOR]),i[n]=e}return i.map((t=>t??"")).join(s)}function f(t,e,s){const[i,n,a,l]=t.getHelmWrappers();return`${i}${o()(e).map((e=>{let i=e;return i=t.isGap(i)?m[r.r2.HELM]:s?i.replace(c.pU,"$1"):1==e.length?`${n}${e}${a}`:`${n}[${e}]${a}`,i})).toArray().join(".")}${l}`}function y(t,e){const s=t.getSplitter()(e),i=new Array(s.length),n=e.startsWith("DNA"),r=e.startsWith("RNA");for(const[t,e]of o().enumerate(s)){let s=t;(n||r)&&(s=s.replace(c.pU,"$1"),s=s===c.$3?null:s),i[e]=s}return i.filter((t=>null!==t))}},9298:(t,e,s)=>{"use strict";var i,n,o,r,a,l;s.d(e,{Ct:()=>l,DX:()=>i,ES:()=>n,dE:()=>a,iD:()=>r,vS:()=>h,vw:()=>o}),function(t){t.tooltipWebLogo=".tooltipWebLogo"}(i||(i={})),function(t){t.Entropy="Entropy",t.full="100%"}(n||(n={})),function(t){t.TOP="top",t.MIDDLE="middle",t.BOTTOM="bottom"}(o||(o={})),function(t){t.LEFT="left",t.CENTER="center",t.RIGHT="right"}(r||(r={})),function(t){t.AUTO="auto",t.ON="on",t.OFF="off"}(a||(a={})),function(t){t.Filtered="Filtered",t.Selected="Selected"}(l||(l={}));const h=new class{constructor(){this.sequenceColumnName=null,this.startPositionName=null,this.endPositionName=null,this.skipEmptySequences=!0,this.skipEmptyPositions=!1,this.shrinkEmptyTail=!0,this.backgroundColor=4294967295,this.positionHeight=n.Entropy,this.positionWidth=16,this.verticalAlignment=o.MIDDLE,this.horizontalAlignment=r.CENTER,this.fixWidth=!1,this.fitArea=!0,this.minHeight=50,this.maxHeight=100,this.showPositionLabels=!0,this.positionMarginState=a.AUTO,this.positionMargin=0,this.filterSource=l.Filtered}}},2669:(t,e,s)=>{"use strict";s.d(e,{m:()=>i});class i{constructor(t=!0,e=!0){const i=navigator.hardwareConcurrency;this._workerCount=t?Math.max(i-2,1):1,this._workers=new Array(this._workerCount).fill(null).map((()=>new Worker(new URL(s.p+s.u(868),s.b)))),this._terminateOnComplete=e}async calc(t,e,s=!0,i){return new Promise((async(n,o)=>{try{const o=t.length,r=new Array(this._workerCount),a=o*(o-1)/2;this._workerCount=Math.min(this._workerCount,a);const l=a/this._workerCount,h=new Float32Array(a);let c=0,u=1,m=0,d=Number.MIN_VALUE;for(let s=0;s<this._workerCount;s++){const n=Math.floor(s*l),g=s===this._workerCount-1?a:Math.floor((s+1)*l),p=c,f=u;s!==this._workerCount-1&&(c=o-2-Math.floor(Math.sqrt(-8*g+4*o*(o-1)-7)/2-.5),u=g-o*c+Math.floor((c+1)*(c+2)/2)),this._workers[s].postMessage({values:t,fnName:e,startRow:p,startCol:f,chunckSize:g-n,opts:i}),r[s]=new Promise(((t,e)=>{this._workers[s].onmessage=({data:{error:i,distanceMatrixData:o,min:r,max:a}})=>{this._terminateOnComplete&&this._workers[s].terminate(),i?e(i):(h.set(o,n),r<m&&(m=r),a>d&&(d=a),t())}}))}await Promise.all(r),s&&h.forEach(((t,e)=>{h[e]=(t-m)/(d-m)})),n(h)}catch(t){o(t)}}))}terminate(){this._workers.forEach((t=>t.terminate()))}}},3914:(t,e,s)=>{"use strict";s.d(e,{H:()=>n});var i=s(6814);class n{get data(){return this._data}get size(){return this._size}constructor(t,e){if(null==e){if(null==t)throw new Error("Arguments error: data or size is required.");if(this._data=t,this._size=(1+Math.sqrt(1+8*this._data.length))/2,this._size!=Math.floor(this._size))throw new Error(`Invalid data length ${this._data.length} leads to non integer size ${this._size}`)}else{this._size=e;const s=e*(e-1)/2;if(t){if(t.length!=s)throw new Error(`Invalid data length. Observations size ${e} requires data length ${s}.`);this._data=t}else this._data=new Float32Array(s)}}_linearizeIJ(t,e){if(!(t<e))throw new Error("i must be less than j");return this._size*t+e-Math.floor((t+2)*(t+1)/2)}get(t,e){return t==e?0:t<e?this._data[this._linearizeIJ(t,e)]:this._data[this._linearizeIJ(e,t)]}set(t,e,s){this._data[this._linearizeIJ(t,e)]=s}static calc(t,e){const s=t.length,o=new n(void 0,s);for(let n=0;n<s;n++)for(let r=n+1;r<s;r++)o.set(n,r,(0,i.k)(t[n])||(0,i.k)(t[r])?1:e(t[n],t[r]));return o}square(){for(let t=0;t<this._data.length;t++)this._data[t]=this._data[t]**2}add(t){if(this._size!==t._size)throw new Error(`Matrices must have the same size. 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o=n.RH(o),function(t){t=n.Fv(t,"max");const e=n.p4(t),s=n.NT(e,t);return t=n.IH(t,n.$X(e,s)),n.RH(t)}(o)}smoothKNNDistance(t,e,s=1,i=64,n=1){const o=Math.log(e)/Math.log(2)*n,r=a.ll(t.length),l=a.ll(t.length);for(let e=0;e<t.length;e++){let n=0,u=1/0,m=1;const d=t[e],g=d.filter((t=>t>0));if(g.length>=s){let t=Math.floor(s),i=s-t;t>0?(r[e]=g[t-1],i>h&&(r[e]+=i*(g[t]-g[t-1]))):r[e]=i*g[0]}else g.length>0&&(r[e]=a.Fp(g));for(let s=0;s<i;s++){let s=0;for(let i=1;i<t[e].length;i++){const n=t[e][i]-r[e];s+=n>0?Math.exp(-n/m):1}if(Math.abs(s-o)<h)break;s>o?(u=m,m=(n+u)/2):(n=m,u===1/0?m*=2:m=(n+u)/2)}if(l[e]=m,r[e]>0){const t=a.J6(d);l[e]<c*t&&(l[e]=c*t)}else{const s=a.J6(t.map(a.J6));l[e]<c*s&&(l[e]=c*s)}}return{sigmas:l,rhos:r}}computeMembershipStrengths(t,e,s,i){const n=t.length,o=t[0].length,r=a.ll(n*o),l=a.ll(n*o),h=a.ll(n*o);for(let a=0;a<n;a++)for(let n=0;n<o;n++){let 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Cannot rescale a constant array");var l=s.min,h=void 0===l?s.autoMinMax?r:0:l,c=s.max,u=void 0===c?s.autoMinMax?a:1:c;if(h>=u)throw new RangeError("min option must be smaller than max option");for(var m=(u-h)/(a-r),d=0;d<t.length;d++)e[d]=(t[d]-r)*m+h;return e}},6241:(t,e,s)=>{"use strict";s.d(e,{N:()=>n});const i=Object.prototype.toString;function n(t){return i.call(t).endsWith("Array]")}},1353:(t,e,s)=>{"use strict";function i(t,e,s){let i=0;const n=s(e);for(let e=0;e<t.x.length;e++)i+=Math.abs(t.y[e]-n(t.x[e]));return i}s.d(e,{Z:()=>i})},3107:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(7531),n=s(1353),o=s(8188);function r(t,e,s={}){let{maxIterations:r=100,gradientDifference:a=.1,damping:l=0,errorTolerance:h=.01,minValues:c,maxValues:u,initialValues:m}=s;if(l<=0)throw new Error("The damping option must be a positive number");if(!t.x||!t.y)throw new Error("The data parameter must have x and y elements");if(!(0,i.Z)(t.x)||t.x.length<2||!(0,i.Z)(t.y)||t.y.length<2)throw new Error("The data parameter elements must be an array with more than 2 points");if(t.x.length!==t.y.length)throw new Error("The data parameter elements must have the same size");let d=m||new Array(e.length).fill(1),g=d.length;if(u=u||new Array(g).fill(Number.MAX_SAFE_INTEGER),c=c||new Array(g).fill(Number.MIN_SAFE_INTEGER),u.length!==c.length)throw new Error("minValues and maxValues must be the same size");if(!(0,i.Z)(d))throw new Error("initialValues must be an array");let p,f=(0,n.Z)(t,d,e),y=f<=h;for(p=0;p<r&&!y;p++){d=(0,o.Z)(t,d,l,a,e);for(let t=0;t<g;t++)d[t]=Math.min(Math.max(c[t],d[t]),u[t]);if(f=(0,n.Z)(t,d,e),isNaN(f))break;y=f<=h}return{parameterValues:d,parameterError:f,iterations:p}}},8188:(t,e,s)=>{"use strict";s.d(e,{Z:()=>o});var i=s(1174),n=s(8345);function o(t,e,s,o,r){let a=s*o*o,l=i.Z.eye(e.length,e.length,a);const h=r(e);let c=new Float64Array(t.x.length);for(let e=0;e<t.x.length;e++)c[e]=h(t.x[e]);let u=function(t,e,s,n,o){const r=s.length,a=t.x.length;let l=new Array(r);for(let i=0;i<r;i++){l[i]=new Array(a);let r=s.slice();r[i]+=n;let h=o(r);for(let s=0;s<a;s++)l[i][s]=e[s]-h(t.x[s])}return new i.Z(l)}(t,c,e,o,r),m=function(t,e){const s=t.x.length;let n=new Array(s);for(let i=0;i<s;i++)n[i]=[t.y[i]-e[i]];return new i.Z(n)}(t,c),d=(0,n.S)(l.add(u.mmul(u.transpose())));return(e=(e=new i.Z([e])).sub(d.mmul(u).mmul(m).mul(o).transpose())).to1DArray()}},5776:(t,e,s)=>{"use strict";s.d(e,{N:()=>n});const i=Object.prototype.toString;function n(t){return i.call(t).endsWith("Array]")}},2313:(t,e,s)=>{"use strict";s.d(e,{Z:()=>o});var i=s(1174),n=s(8353);class o{constructor(t){let e,s,i,o,r,a,l,h,c,u=(t=n.Z.checkMatrix(t)).clone(),m=u.rows,d=u.columns,g=new Float64Array(m),p=1;for(e=0;e<m;e++)g[e]=e;for(h=new Float64Array(m),s=0;s<d;s++){for(e=0;e<m;e++)h[e]=u.get(e,s);for(e=0;e<m;e++){for(c=Math.min(e,s),r=0,i=0;i<c;i++)r+=u.get(e,i)*h[i];h[e]-=r,u.set(e,s,h[e])}for(o=s,e=s+1;e<m;e++)Math.abs(h[e])>Math.abs(h[o])&&(o=e);if(o!==s){for(i=0;i<d;i++)a=u.get(o,i),u.set(o,i,u.get(s,i)),u.set(s,i,a);l=g[o],g[o]=g[s],g[s]=l,p=-p}if(s<m&&0!==u.get(s,s))for(e=s+1;e<m;e++)u.set(e,s,u.get(e,s)/u.get(s,s))}this.LU=u,this.pivotVector=g,this.pivotSign=p}isSingular(){let t=this.LU,e=t.columns;for(let s=0;s<e;s++)if(0===t.get(s,s))return!0;return!1}solve(t){t=i.Z.checkMatrix(t);let e=this.LU;if(e.rows!==t.rows)throw new Error("Invalid matrix dimensions");if(this.isSingular())throw new Error("LU matrix is singular");let s,n,o,r=t.columns,a=t.subMatrixRow(this.pivotVector,0,r-1),l=e.columns;for(o=0;o<l;o++)for(s=o+1;s<l;s++)for(n=0;n<r;n++)a.set(s,n,a.get(s,n)-a.get(o,n)*e.get(s,o));for(o=l-1;o>=0;o--){for(n=0;n<r;n++)a.set(o,n,a.get(o,n)/e.get(o,o));for(s=0;s<o;s++)for(n=0;n<r;n++)a.set(s,n,a.get(s,n)-a.get(o,n)*e.get(s,o))}return a}get determinant(){let t=this.LU;if(!t.isSquare())throw new Error("Matrix must be square");let e=this.pivotSign,s=t.columns;for(let i=0;i<s;i++)e*=t.get(i,i);return e}get lowerTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new i.Z(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i>e?n.set(i,e,t.get(i,e)):i===e?n.set(i,e,1):n.set(i,e,0);return n}get upperTriangularMatrix(){let t=this.LU,e=t.rows,s=t.columns,n=new i.Z(e,s);for(let i=0;i<e;i++)for(let e=0;e<s;e++)i<=e?n.set(i,e,t.get(i,e)):n.set(i,e,0);return n}get pivotPermutationVector(){return Array.from(this.pivotVector)}}},7072:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(1174),n=s(8353),o=s(6310);class r{constructor(t){let e,s,i,r,a=(t=n.Z.checkMatrix(t)).clone(),l=t.rows,h=t.columns,c=new Float64Array(h);for(i=0;i<h;i++){let t=0;for(e=i;e<l;e++)t=(0,o.G)(t,a.get(e,i));if(0!==t){for(a.get(i,i)<0&&(t=-t),e=i;e<l;e++)a.set(e,i,a.get(e,i)/t);for(a.set(i,i,a.get(i,i)+1),s=i+1;s<h;s++){for(r=0,e=i;e<l;e++)r+=a.get(e,i)*a.get(e,s);for(r=-r/a.get(i,i),e=i;e<l;e++)a.set(e,s,a.get(e,s)+r*a.get(e,i))}}c[i]=-t}this.QR=a,this.Rdiag=c}solve(t){t=i.Z.checkMatrix(t);let e=this.QR,s=e.rows;if(t.rows!==s)throw new Error("Matrix row dimensions must agree");if(!this.isFullRank())throw new Error("Matrix is rank deficient");let n,o,r,a,l=t.columns,h=t.clone(),c=e.columns;for(r=0;r<c;r++)for(o=0;o<l;o++){for(a=0,n=r;n<s;n++)a+=e.get(n,r)*h.get(n,o);for(a=-a/e.get(r,r),n=r;n<s;n++)h.set(n,o,h.get(n,o)+a*e.get(n,r))}for(r=c-1;r>=0;r--){for(o=0;o<l;o++)h.set(r,o,h.get(r,o)/this.Rdiag[r]);for(n=0;n<r;n++)for(o=0;o<l;o++)h.set(n,o,h.get(n,o)-h.get(r,o)*e.get(n,r))}return h.subMatrix(0,c-1,0,l-1)}isFullRank(){let t=this.QR.columns;for(let e=0;e<t;e++)if(0===this.Rdiag[e])return!1;return!0}get upperTriangularMatrix(){let t,e,s=this.QR,n=s.columns,o=new i.Z(n,n);for(t=0;t<n;t++)for(e=0;e<n;e++)t<e?o.set(t,e,s.get(t,e)):t===e?o.set(t,e,this.Rdiag[t]):o.set(t,e,0);return o}get orthogonalMatrix(){let t,e,s,n,o=this.QR,r=o.rows,a=o.columns,l=new i.Z(r,a);for(s=a-1;s>=0;s--){for(t=0;t<r;t++)l.set(t,s,0);for(l.set(s,s,1),e=s;e<a;e++)if(0!==o.get(s,s)){for(n=0,t=s;t<r;t++)n+=o.get(t,s)*l.get(t,e);for(n=-n/o.get(s,s),t=s;t<r;t++)l.set(t,e,l.get(t,e)+n*o.get(t,s))}}return l}}},6943:(t,e,s)=>{"use strict";s.d(e,{Z:()=>r});var i=s(1174),n=s(8353),o=s(6310);class r{constructor(t,e={}){if((t=n.Z.checkMatrix(t)).isEmpty())throw new Error("Matrix must be non-empty");let s=t.rows,r=t.columns;const{computeLeftSingularVectors:a=!0,computeRightSingularVectors:l=!0,autoTranspose:h=!1}=e;let c,u=Boolean(a),m=Boolean(l),d=!1;if(s<r)if(h){c=t.transpose(),s=c.rows,r=c.columns,d=!0;let e=u;u=m,m=e}else c=t.clone(),console.warn("Computing SVD on a matrix with more columns than rows. Consider enabling autoTranspose");else c=t.clone();let g=Math.min(s,r),p=Math.min(s+1,r),f=new Float64Array(p),y=new i.Z(s,g),b=new i.Z(r,r),w=new Float64Array(r),C=new Float64Array(s),v=new Float64Array(p);for(let t=0;t<p;t++)v[t]=t;let S=Math.min(s-1,r),T=Math.max(0,Math.min(r-2,s)),M=Math.max(S,T);for(let t=0;t<M;t++){if(t<S){f[t]=0;for(let e=t;e<s;e++)f[t]=(0,o.G)(f[t],c.get(e,t));if(0!==f[t]){c.get(t,t)<0&&(f[t]=-f[t]);for(let e=t;e<s;e++)c.set(e,t,c.get(e,t)/f[t]);c.set(t,t,c.get(t,t)+1)}f[t]=-f[t]}for(let e=t+1;e<r;e++){if(t<S&&0!==f[t]){let i=0;for(let n=t;n<s;n++)i+=c.get(n,t)*c.get(n,e);i=-i/c.get(t,t);for(let n=t;n<s;n++)c.set(n,e,c.get(n,e)+i*c.get(n,t))}w[e]=c.get(t,e)}if(u&&t<S)for(let e=t;e<s;e++)y.set(e,t,c.get(e,t));if(t<T){w[t]=0;for(let e=t+1;e<r;e++)w[t]=(0,o.G)(w[t],w[e]);if(0!==w[t]){w[t+1]<0&&(w[t]=0-w[t]);for(let e=t+1;e<r;e++)w[e]/=w[t];w[t+1]+=1}if(w[t]=-w[t],t+1<s&&0!==w[t]){for(let e=t+1;e<s;e++)C[e]=0;for(let e=t+1;e<s;e++)for(let s=t+1;s<r;s++)C[e]+=w[s]*c.get(e,s);for(let e=t+1;e<r;e++){let i=-w[e]/w[t+1];for(let n=t+1;n<s;n++)c.set(n,e,c.get(n,e)+i*C[n])}}if(m)for(let e=t+1;e<r;e++)b.set(e,t,w[e])}}let A=Math.min(r,s+1);if(S<r&&(f[S]=c.get(S,S)),s<A&&(f[A-1]=0),T+1<A&&(w[T]=c.get(T,A-1)),w[A-1]=0,u){for(let t=S;t<g;t++){for(let e=0;e<s;e++)y.set(e,t,0);y.set(t,t,1)}for(let t=S-1;t>=0;t--)if(0!==f[t]){for(let e=t+1;e<g;e++){let i=0;for(let n=t;n<s;n++)i+=y.get(n,t)*y.get(n,e);i=-i/y.get(t,t);for(let n=t;n<s;n++)y.set(n,e,y.get(n,e)+i*y.get(n,t))}for(let e=t;e<s;e++)y.set(e,t,-y.get(e,t));y.set(t,t,1+y.get(t,t));for(let e=0;e<t-1;e++)y.set(e,t,0)}else{for(let e=0;e<s;e++)y.set(e,t,0);y.set(t,t,1)}}if(m)for(let t=r-1;t>=0;t--){if(t<T&&0!==w[t])for(let e=t+1;e<r;e++){let s=0;for(let i=t+1;i<r;i++)s+=b.get(i,t)*b.get(i,e);s=-s/b.get(t+1,t);for(let i=t+1;i<r;i++)b.set(i,e,b.get(i,e)+s*b.get(i,t))}for(let e=0;e<r;e++)b.set(e,t,0);b.set(t,t,1)}let E=A-1,x=0,I=Number.EPSILON;for(;A>0;){let t,e;for(t=A-2;t>=-1&&-1!==t;t--){const e=Number.MIN_VALUE+I*Math.abs(f[t]+Math.abs(f[t+1]));if(Math.abs(w[t])<=e||Number.isNaN(w[t])){w[t]=0;break}}if(t===A-2)e=4;else{let s;for(s=A-1;s>=t&&s!==t;s--){let e=(s!==A?Math.abs(w[s]):0)+(s!==t+1?Math.abs(w[s-1]):0);if(Math.abs(f[s])<=I*e){f[s]=0;break}}s===t?e=3:s===A-1?e=1:(e=2,t=s)}switch(t++,e){case 1:{let e=w[A-2];w[A-2]=0;for(let s=A-2;s>=t;s--){let i=(0,o.G)(f[s],e),n=f[s]/i,a=e/i;if(f[s]=i,s!==t&&(e=-a*w[s-1],w[s-1]=n*w[s-1]),m)for(let t=0;t<r;t++)i=n*b.get(t,s)+a*b.get(t,A-1),b.set(t,A-1,-a*b.get(t,s)+n*b.get(t,A-1)),b.set(t,s,i)}break}case 2:{let e=w[t-1];w[t-1]=0;for(let i=t;i<A;i++){let n=(0,o.G)(f[i],e),r=f[i]/n,a=e/n;if(f[i]=n,e=-a*w[i],w[i]=r*w[i],u)for(let e=0;e<s;e++)n=r*y.get(e,i)+a*y.get(e,t-1),y.set(e,t-1,-a*y.get(e,i)+r*y.get(e,t-1)),y.set(e,i,n)}break}case 3:{const e=Math.max(Math.abs(f[A-1]),Math.abs(f[A-2]),Math.abs(w[A-2]),Math.abs(f[t]),Math.abs(w[t])),i=f[A-1]/e,n=f[A-2]/e,a=w[A-2]/e,l=f[t]/e,h=w[t]/e,c=((n+i)*(n-i)+a*a)/2,d=i*a*(i*a);let g=0;0===c&&0===d||(g=c<0?0-Math.sqrt(c*c+d):Math.sqrt(c*c+d),g=d/(c+g));let p=(l+i)*(l-i)+g,C=l*h;for(let e=t;e<A-1;e++){let i=(0,o.G)(p,C);0===i&&(i=Number.MIN_VALUE);let n=p/i,a=C/i;if(e!==t&&(w[e-1]=i),p=n*f[e]+a*w[e],w[e]=n*w[e]-a*f[e],C=a*f[e+1],f[e+1]=n*f[e+1],m)for(let t=0;t<r;t++)i=n*b.get(t,e)+a*b.get(t,e+1),b.set(t,e+1,-a*b.get(t,e)+n*b.get(t,e+1)),b.set(t,e,i);if(i=(0,o.G)(p,C),0===i&&(i=Number.MIN_VALUE),n=p/i,a=C/i,f[e]=i,p=n*w[e]+a*f[e+1],f[e+1]=-a*w[e]+n*f[e+1],C=a*w[e+1],w[e+1]=n*w[e+1],u&&e<s-1)for(let t=0;t<s;t++)i=n*y.get(t,e)+a*y.get(t,e+1),y.set(t,e+1,-a*y.get(t,e)+n*y.get(t,e+1)),y.set(t,e,i)}w[A-2]=p,x+=1;break}case 4:if(f[t]<=0&&(f[t]=f[t]<0?-f[t]:0,m))for(let e=0;e<=E;e++)b.set(e,t,-b.get(e,t));for(;t<E&&!(f[t]>=f[t+1]);){let e=f[t];if(f[t]=f[t+1],f[t+1]=e,m&&t<r-1)for(let 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o=0;o<s;o++)for(let s=0;s<i;s++)n.set(o,s,Math.max(t.get(o,s),e.get(o,s)));return n}static checkMatrix(t){return h.isMatrix(t)?t:new u(t)}static isMatrix(t){return null!=t&&"Matrix"===t.klass}get size(){return this.rows*this.columns}apply(t){if("function"!=typeof t)throw new TypeError("callback must be a function");for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.call(this,e,s);return this}to1DArray(){let t=[];for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t.push(this.get(e,s));return t}to2DArray(){let t=[];for(let e=0;e<this.rows;e++){t.push([]);for(let s=0;s<this.columns;s++)t[e].push(this.get(e,s))}return t}toJSON(){return this.to2DArray()}isRowVector(){return 1===this.rows}isColumnVector(){return 1===this.columns}isVector(){return 1===this.rows||1===this.columns}isSquare(){return this.rows===this.columns}isEmpty(){return 0===this.rows||0===this.columns}isSymmetric(){if(this.isSquare()){for(let t=0;t<this.rows;t++)for(let e=0;e<=t;e++)if(this.get(t,e)!==this.get(e,t))return!1;return!0}return!1}isEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);t++}return i}isReducedEchelonForm(){let t=0,e=0,s=-1,i=!0,n=!1;for(;t<this.rows&&i;){for(e=0,n=!1;e<this.columns&&!1===n;)0===this.get(t,e)?e++:1===this.get(t,e)&&e>s?(n=!0,s=e):(i=!1,n=!0);for(let s=e+1;s<this.rows;s++)0!==this.get(t,s)&&(i=!1);t++}return i}echelonForm(){let t=this.clone(),e=0,s=0;for(;e<t.rows&&s<t.columns;){let i=e;for(let n=e;n<t.rows;n++)t.get(n,s)>t.get(i,s)&&(i=n);if(0===t.get(i,s))s++;else{t.swapRows(e,i);let n=t.get(e,s);for(let i=s;i<t.columns;i++)t.set(e,i,t.get(e,i)/n);for(let i=e+1;i<t.rows;i++){let n=t.get(i,s)/t.get(e,s);t.set(i,s,0);for(let o=s+1;o<t.columns;o++)t.set(i,o,t.get(i,o)-t.get(e,o)*n)}e++,s++}}return t}reducedEchelonForm(){let t=this.echelonForm(),e=t.columns,s=t.rows,i=s-1;for(;i>=0;)if(0===t.maxRow(i))i--;else{let n=0,o=!1;for(;n<s&&!1===o;)1===t.get(i,n)?o=!0:n++;for(let s=0;s<i;s++){let o=t.get(s,n);for(let r=n;r<e;r++){let e=t.get(s,r)-o*t.get(i,r);t.set(s,r,e)}}i--}return t}set(){throw new Error("set method is unimplemented")}get(){throw new Error("get method is unimplemented")}repeat(t={}){if("object"!=typeof t)throw new TypeError("options must be an object");const{rows:e=1,columns:s=1}=t;if(!Number.isInteger(e)||e<=0)throw new TypeError("rows must be a positive integer");if(!Number.isInteger(s)||s<=0)throw new TypeError("columns must be a positive integer");let i=new u(this.rows*e,this.columns*s);for(let t=0;t<e;t++)for(let e=0;e<s;e++)i.setSubMatrix(this,this.rows*t,this.columns*e);return i}fill(t){for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,t);return this}neg(){return this.mulS(-1)}getRow(t){(0,l.zb)(this,t);let e=[];for(let s=0;s<this.columns;s++)e.push(this.get(t,s));return e}getRowVector(t){return u.rowVector(this.getRow(t))}setRow(t,e){(0,l.zb)(this,t),e=(0,l.on)(this,e);for(let s=0;s<this.columns;s++)this.set(t,s,e[s]);return this}swapRows(t,e){(0,l.zb)(this,t),(0,l.zb)(this,e);for(let s=0;s<this.columns;s++){let i=this.get(t,s);this.set(t,s,this.get(e,s)),this.set(e,s,i)}return this}getColumn(t){(0,l.bp)(this,t);let e=[];for(let s=0;s<this.rows;s++)e.push(this.get(s,t));return e}getColumnVector(t){return u.columnVector(this.getColumn(t))}setColumn(t,e){(0,l.bp)(this,t),e=(0,l.Um)(this,e);for(let s=0;s<this.rows;s++)this.set(s,t,e[s]);return this}swapColumns(t,e){(0,l.bp)(this,t),(0,l.bp)(this,e);for(let s=0;s<this.rows;s++){let i=this.get(s,t);this.set(s,t,this.get(s,e)),this.set(s,e,i)}return this}addRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[s]);return this}subRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[s]);return this}mulRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[s]);return this}divRowVector(t){t=(0,l.on)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[s]);return this}addColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)+t[e]);return this}subColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)-t[e]);return this}mulColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)*t[e]);return this}divColumnVector(t){t=(0,l.Um)(this,t);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.set(e,s,this.get(e,s)/t[e]);return this}mulRow(t,e){(0,l.zb)(this,t);for(let s=0;s<this.columns;s++)this.set(t,s,this.get(t,s)*e);return this}mulColumn(t,e){(0,l.bp)(this,t);for(let s=0;s<this.rows;s++)this.set(s,t,this.get(s,t)*e);return this}max(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.NEGATIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)>t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}maxIndex(){(0,l.cT)(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)>t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}min(t){if(this.isEmpty())return NaN;switch(t){case"row":{const t=new Array(this.rows).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[e]&&(t[e]=this.get(e,s));return t}case"column":{const t=new Array(this.columns).fill(Number.POSITIVE_INFINITY);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t[s]&&(t[s]=this.get(e,s));return t}case void 0:{let t=this.get(0,0);for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)this.get(e,s)<t&&(t=this.get(e,s));return t}default:throw new Error(`invalid option: ${t}`)}}minIndex(){(0,l.cT)(this);let t=this.get(0,0),e=[0,0];for(let s=0;s<this.rows;s++)for(let i=0;i<this.columns;i++)this.get(s,i)<t&&(t=this.get(s,i),e[0]=s,e[1]=i);return e}maxRow(t){if((0,l.zb)(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)>e&&(e=this.get(t,s));return e}maxRowIndex(t){(0,l.zb)(this,t),(0,l.cT)(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)>e&&(e=this.get(t,i),s[1]=i);return s}minRow(t){if((0,l.zb)(this,t),this.isEmpty())return NaN;let e=this.get(t,0);for(let s=1;s<this.columns;s++)this.get(t,s)<e&&(e=this.get(t,s));return e}minRowIndex(t){(0,l.zb)(this,t),(0,l.cT)(this);let e=this.get(t,0),s=[t,0];for(let i=1;i<this.columns;i++)this.get(t,i)<e&&(e=this.get(t,i),s[1]=i);return s}maxColumn(t){if((0,l.bp)(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)>e&&(e=this.get(s,t));return e}maxColumnIndex(t){(0,l.bp)(this,t),(0,l.cT)(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)>e&&(e=this.get(i,t),s[0]=i);return s}minColumn(t){if((0,l.bp)(this,t),this.isEmpty())return NaN;let e=this.get(0,t);for(let s=1;s<this.rows;s++)this.get(s,t)<e&&(e=this.get(s,t));return e}minColumnIndex(t){(0,l.bp)(this,t),(0,l.cT)(this);let e=this.get(0,t),s=[0,t];for(let i=1;i<this.rows;i++)this.get(i,t)<e&&(e=this.get(i,t),s[0]=i);return s}diag(){let t=Math.min(this.rows,this.columns),e=[];for(let s=0;s<t;s++)e.push(this.get(s,s));return e}norm(t="frobenius"){let e=0;if("max"===t)return this.max();if("frobenius"===t){for(let t=0;t<this.rows;t++)for(let s=0;s<this.columns;s++)e+=this.get(t,s)*this.get(t,s);return Math.sqrt(e)}throw new RangeError(`unknown norm type: ${t}`)}cumulativeSum(){let t=0;for(let e=0;e<this.rows;e++)for(let s=0;s<this.columns;s++)t+=this.get(e,s),this.set(e,s,t);return this}dot(t){h.isMatrix(t)&&(t=t.to1DArray());let e=this.to1DArray();if(e.length!==t.length)throw new RangeError("vectors do not have the same size");let s=0;for(let i=0;i<e.length;i++)s+=e[i]*t[i];return s}mmul(t){t=u.checkMatrix(t);let e=this.rows,s=this.columns,i=t.columns,n=new u(e,i),o=new Float64Array(s);for(let r=0;r<i;r++){for(let e=0;e<s;e++)o[e]=t.get(e,r);for(let t=0;t<e;t++){let e=0;for(let i=0;i<s;i++)e+=this.get(t,i)*o[i];n.set(t,r,e)}}return n}strassen2x2(t){t=u.checkMatrix(t);let e=new u(2,2);const s=this.get(0,0),i=t.get(0,0),n=this.get(0,1),o=t.get(0,1),r=this.get(1,0),a=t.get(1,0),l=this.get(1,1),h=t.get(1,1),c=(s+l)*(i+h),m=(r+l)*i,d=s*(o-h),g=l*(a-i),p=(s+n)*h,f=c+g-p+(n-l)*(a+h),y=d+p,b=m+g,w=c-m+d+(r-s)*(i+o);return e.set(0,0,f),e.set(0,1,y),e.set(1,0,b),e.set(1,1,w),e}strassen3x3(t){t=u.checkMatrix(t);let e=new u(3,3);const s=this.get(0,0),i=this.get(0,1),n=this.get(0,2),o=this.get(1,0),r=this.get(1,1),a=this.get(1,2),l=this.get(2,0),h=this.get(2,1),c=this.get(2,2),m=t.get(0,0),d=t.get(0,1),g=t.get(0,2),p=t.get(1,0),f=t.get(1,1),y=t.get(1,2),b=t.get(2,0),w=t.get(2,1),C=t.get(2,2),v=(s-o)*(-d+f),S=(-s+o+r)*(m-d+f),T=(o+r)*(-m+d),M=s*m,A=(-s+l+h)*(m-g+y),E=(-s+l)*(g-y),x=(l+h)*(-m+g),I=(-n+h+c)*(f+b-w),N=(n-c)*(f-w),L=n*b,_=(h+c)*(-b+w),R=(-n+r+a)*(y+b-C),O=(n-a)*(y-C),k=(r+a)*(-b+C),P=M+L+i*p,G=(s+i+n-o-r-h-c)*f+S+T+M+I+L+_,F=M+A+x+(s+i+n-r-a-l-h)*y+L+R+k,H=v+r*(-m+d+p-f-y-b+C)+S+M+L+R+O,V=v+S+T+M+a*w,W=L+R+O+k+o*g,D=M+A+E+h*(-m+g+p-f-y-b+w)+I+N+L,B=I+N+L+_+l*d,U=M+A+E+x+c*C;return e.set(0,0,P),e.set(0,1,G),e.set(0,2,F),e.set(1,0,H),e.set(1,1,V),e.set(1,2,W),e.set(2,0,D),e.set(2,1,B),e.set(2,2,U),e}mmulStrassen(t){t=u.checkMatrix(t);let e=this.clone(),s=e.rows,i=e.columns,n=t.rows,o=t.columns;function r(t,e,s){let i=t.rows,n=t.columns;if(i===e&&n===s)return t;{let i=h.zeros(e,s);return i=i.setSubMatrix(t,0,0),i}}i!==n&&console.warn(`Multiplying ${s} x ${i} and ${n} x ${o} matrix: dimensions do not match.`);let a=Math.max(s,n),l=Math.max(i,o);return e=r(e,a,l),function t(e,s,i,n){if(i<=512||n<=512)return e.mmul(s);i%2==1&&n%2==1?(e=r(e,i+1,n+1),s=r(s,i+1,n+1)):i%2==1?(e=r(e,i+1,n),s=r(s,i+1,n)):n%2==1&&(e=r(e,i,n+1),s=r(s,i,n+1));let o=parseInt(e.rows/2,10),a=parseInt(e.columns/2,10),l=e.subMatrix(0,o-1,0,a-1),c=s.subMatrix(0,o-1,0,a-1),u=e.subMatrix(0,o-1,a,e.columns-1),m=s.subMatrix(0,o-1,a,s.columns-1),d=e.subMatrix(o,e.rows-1,0,a-1),g=s.subMatrix(o,s.rows-1,0,a-1),p=e.subMatrix(o,e.rows-1,a,e.columns-1),f=s.subMatrix(o,s.rows-1,a,s.columns-1),y=t(h.add(l,p),h.add(c,f),o,a),b=t(h.add(d,p),c,o,a),w=t(l,h.sub(m,f),o,a),C=t(p,h.sub(g,c),o,a),v=t(h.add(l,u),f,o,a),S=t(h.sub(d,l),h.add(c,m),o,a),T=t(h.sub(u,p),h.add(g,f),o,a),M=h.add(y,C);M.sub(v),M.add(T);let A=h.add(w,v),E=h.add(b,C),x=h.sub(y,b);x.add(w),x.add(S);let I=h.zeros(2*M.rows,2*M.columns);return 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strict";s.r(e),s.d(e,{BYPASS_LARGE_DATA_WARNING:()=>je,GetRegionEditor:()=>rs,SeqActivityCliffsEditor:()=>hs,SeqPaletteCustom:()=>ts,SequenceSpaceEditor:()=>ls,SplitToMonomersEditor:()=>as,SubsequenceSearchTopMenu:()=>Vs,_package:()=>Ke,activityCliffs:()=>vs,addCopyMenu:()=>qs,alignSequences:()=>As,bioSubstructureFilter:()=>Us,compositionAnalysis:()=>Es,compositionAnalysisWidget:()=>ds,convertDialog:()=>Ns,demoBioActivityCliffs:()=>Ks,demoBioAtomicLevel:()=>js,demoBioHelmMsaSequenceSpace:()=>Js,demoBioSequenceSpace:()=>Xs,demoBioSimilarityDiversity:()=>$s,diversitySearchTopMenu:()=>Fs,diversitySearchViewer:()=>Gs,enumeratorColumnChoice:()=>Qs,fastaSequenceCellRenderer:()=>us,getBioLib:()=>is,getEnumeratorWidget:()=>ti,getHelmMonomers:()=>Os,getMonomerLibHelper:()=>Je,getRegion:()=>ws,getRegionApp:()=>Ys,getRegionHelmApp:()=>zs,getRegionPanel:()=>ns,getRegionTopMenu:()=>Cs,hydrophobPalette:()=>Qe,importBam:()=>Is,importFasta:()=>xs,initBio:()=>es,libraryPanel:()=>os,macroMolColumnPropertyPanel:()=>ms,macromoleculeDifferenceCellRenderer:()=>ps,monomerCellRenderer:()=>Ls,multipleSequenceAlignmentDialog:()=>Ms,packageSettingsEditor:()=>cs,saveAsFasta:()=>Bs,sdfToJsonLib:()=>ei,searchSubsequenceEditor:()=>Hs,separatorSequenceCellRenderer:()=>gs,sequenceAlignment:()=>fs,sequenceIdentityScoring:()=>Ws,sequenceSimilarityScoring:()=>Ds,sequenceSpaceTopMenu:()=>Ss,sequenceTooltip:()=>ss,similaritySearchTopMenu:()=>Ps,similaritySearchViewer:()=>ks,splitToMonomersTopMenu:()=>Rs,testDetectMacromolecule:()=>_s,toAtomicLevel:()=>Ts,vdRegionsViewer:()=>bs,webLogoLargeApp:()=>Zs,webLogoViewer:()=>ys});var i=s(4469),n=s(3870),o=s(976),r=s(6414),a=s.n(r),l=s(585);const h="rgb(100,100,100)",c="#808080",u="rgb(0,0,0)",m=l.GU;var d,g;function p(t,e,s,i,n,o,r=h,a=0,l=!1,d=1,p="",f=!1,y=g.classic,b=[],w=0,C=null,v=[],S=null,T={}){n.textAlign="start";let M=o.substring(0),A=f?"":p;y===g.MSA&&(A="");let E=!0,x=!0,I="difference";null!=C&&null!=C.cell.column&&(E=C.cell.column.temp["color-code"]??!0,x=C.cell.column.temp["compare-with-current"]??!0,I=C.cell.column.temp["highlight-difference"]??"difference");const N=v[w];x&&v.length>0&&"difference"===I&&(d=M==N?.3:d),x&&v.length>0&&"equal"===I&&(d=M!=N?.3:d),null!=S&&(M=m(M,S));const L=M+A;T[L]??(T[L]=n.measureText(L));let _=T[L];T[M]??(T[M]=n.measureText(M));let R=T[M].width;T[A]??(T[A]=n.measureText(A));const O=T[A].width,k=i/2-(_.fontBoundingBoxAscent+_.fontBoundingBoxDescent)/2+1;function P(s,i){const o=E?r:u;n.fillStyle=o,n.globalAlpha=d,y===g.classic&&(n.fillText(M,t+s,e+k),n.fillStyle=c,n.fillText(A,t+i,e+k)),y===g.MSA&&n.fillText(M,t+s,e+k)}_=_.width,y===g.MSA&&(R=b[w],_=b[w]);const G=(b[w]??0)-(b[0]??0);if(l||_>s)return P(G,G+R),t+G+R+O;{const e=(s-_)/2;return P(e,e+R),t+G+e+R}}!function(t){t.maxMonomerLength=".mm.cellRenderer.maxMonomerLength"}(d||(d={})),function(t){t.MSA="MSA",t.classic="classic"}(g||(g={}));var f,y=s(9611),b=s(8447),w=s(7331),C=s(499);!function(t){t.long="long",t.short="short"}(f||(f={}));const v={true:"1",false:"0"};var S=s(3553),T=s(7958);const M="rgb(100,100,100)",A=b.GU;function E(t,e,s,i,n){return t?Math.max(Math.min(t.canvas.width/n-s,i)):Math.max(e.canvas.width/n-s,0)}function x(t){const e=!a().enumerate(t).some((([e,s])=>e.length>1&&0!=s&&s!=t.length-1)),s=[],i=e?"":" ";for(const[e,n]of a().enumerate(t)){let o=e;n<t.length&&(o+=`${e?"":"-"}${i}`),s.push(o)}return[s,e]}class I extends o.GridCellRenderer{constructor(){super(...arguments),this.padding=5}get name(){return"sequence"}get cellType(){return"sequence"}get defaultHeight(){return 30}get defaultWidth(){return 230}onClick(t,e){t.cell.column.temp["current-word"]=t.cell.value,t.grid.invalidate()}onMouseMove(t,e){const s=t.cell.column.temp["bio-seqCol"];if(!s)return;const o=t.bounds,r=e.offsetX-t.gridColumn.left+(t.gridColumn.left-o.x),a=s.getPosition(t.tableRowIndex,r),l=s.getSeqMonList(t.tableRowIndex);if(null!==a&&a<l.length){const t=l[a],o=[n.div(t)];if(s._monomerStructureMap[t])o.push(s._monomerStructureMap[t]);else{const e=s.getMonomer(t);if(e){const n={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0},r=i.chem.svgMol(e.smiles,void 0,void 0,n);o.push(r),s._monomerStructureMap[t]=r}}n.tooltip.show(n.divV(o),e.x+16,e.y+16)}else n.tooltip.hide()}render(t,e,s,i,n,r,l){let h,c=0,u=50;try{h=r.grid}catch(t){h=void 0;const[e,s]=(0,T.yf)(t);Ke.logger.error(e,void 0,s)}const m=r.cell.column;if(!h||!m)return;const f=m.temp,w=f["monomer-width"];if("short"===(null!=w?w:"short")){const t=parseInt(m.getTag(d.maxMonomerLength));u=(isNaN(t)?Ke.properties?.MaxMonomerLength:t)??4}let S=m.temp["bio-seqCol"];S||(S=new y.A(h,m,(()=>{const t=C.Cn.getOrCreate(m);return{unitsHandler:t,monomerCharWidth:7,separatorWidth:t.isMsa()?8:c,monomerToShort:A,monomerLengthLimit:u,monomerLib:is()}}))),m.tags[".mm.cellRenderer.settingsChanged"]===v.true&&(c=f[".mm.cellRenderer.gapLength"]??c,S.setMonomerLengthLimit(u),S.setSeparatorWidth(S.isMsa()?8:c),m.setTag(".mm.cellRenderer.settingsChanged",v.false));const[x,I]=S.getCellMonomerLengths(r.tableRowIndex);x.length,S.updated&&(f["bio-seqCol"]=S),t.save();try{const l=window.devicePixelRatio,h=-1!==r.gridRow?r.grid:null,c=r.cell.value,d=m.getTag("alphabet"),y=50;i=E(h,t,e,i,l),t.beginPath(),t.rect(e+this.padding,s+this.padding,i-this.padding-1,n-2*this.padding),t.clip(),t.font="12px monospace",t.textBaseline="top";const w=m.getTag(o.TAGS.UNITS),v=m.getTag("aligned"),T=(0,b.py)(d),A=m.getTag("separator")??"",x=i/5,N=C.Cn.getOrCreate(m).getSplitter(x),L=f["reference-sequence"],_=f["current-word"],R=N(null!=L&&""!=L?L:_??""),O=N(c);let k=M,P=g.classic;v&&v.includes("MSA")&&w==b.r2.SEPARATOR&&(P=g.MSA);for(const[o,l]of a().enumerate(O)){k=T.get(o),t.fillStyle=M;const a=l===O.length-1;if(p(e+this.padding,s,i,n,t,o,k,0,!0,1,A,a,P,I,l,r,R,u,S._monomerLengthMap),y>i)break}}catch(t){const e=t instanceof Error?t.message:t?t.toString():"Error 'undefined'";Ke.logger.error(`Bio: MacromoleculeSequenceCellRenderer.render() error: ${e}`)}finally{t.restore()}}}class N extends o.GridCellRenderer{get name(){return"MacromoleculeDifferenceCR"}get cellType(){return S.Of.MACROMOLECULE_DIFFERENCE}get defaultHeight(){return 30}get defaultWidth(){return 230}render(t,e,s,i,n,r,a){const h=window.devicePixelRatio,c=r.grid,u=r.cell,m=r.tableColumn,d=u.value??"",g=m.tags.separator,p=m.tags[o.TAGS.UNITS];i=E(c,t,e,i,h);const[f,y]=d.split("#"),b=(0,l.vU)(p,g);L(t,e,s,i,n,b(f),b(y),p)}}function L(t,e,s,i,n,o,r,l,h,c){if(o.length!==r.length){const t=function(t,e){let s=0,i=0;const n=t.length>e.length?t:e,o=t.length>e.length?e:t;for(let t=0;t<o.length;t++)n[t]===o[t]&&s++;const r=n.length-o.length;for(let t=n.length-1;t>r;t--)n[t]===o[t-r]&&i++;const a=new Array(Math.abs(t.length-e.length)).fill("");function l(t){return s>i?t.concat(a):a.concat(t)}return t.length>e.length?e=l(e):t=l(t),{subParts1:t,subParts2:e}}(a()(o).toArray(),a()(r).toArray());o=t.subParts1,r=t.subParts2}const u=t.measureText(x(o).join("")),m=t.measureText(x(r).join("")),d=Math.max(u.width,m.width);h&&(i=d+4*o.length,t.canvas.width=d+4*o.length);let g=Math.max(e,e+(i-(d+4*o.length))/2)+5;const f=Math.max(s,s+(n-28)/2);t.save(),t.beginPath(),t.rect(e,s,h?d+4*o.length:i,n),t.clip(),t.font="12px monospace",t.textBaseline="top";let y=w.UE.Color;"HELM"!=l&&(y=(0,b.py)(l.substring(l.length-2)));for(let e=0;e<o.length;e++){const s=o[e],a=r[e],l=y.get(s);if(s!=a){const o=y.get(a),r=p(g,f-7,i,n,t,s,l,0,!0),h=p(g,f+7,i,n,t,a,o,0,!0);g=Math.max(h,r),c&&(c[e]=_(s,a,l,o,f,7,n))}else g=p(g,f,i,n,t,s,l,0,!0,.5);g+=4}t.restore()}function _(t,e,s,i,n,o,r){const a=document.createElement("canvas"),l=a.getContext("2d");l.font="12px monospace";const h=l.measureText(x([t]).join("")).width,c=l.measureText(x([e]).join("")).width,u=Math.max(h,c);return a.height=r,a.width=u+4,l.font="12px monospace",l.textBaseline="top",p(0,n-o,u,r,l,t,s,0,!0),p(0,n+o,u,r,l,e,i,0,!0),a}var R,O=s(701),k=s(9298);!function(t){t.Unknown="unknown",t.FR="framework",t.CDR="cdr"}(R||(R={}));const P=new class{constructor(){this.regionTypes=[R.CDR],this.chains=["Heavy","Light"],this.skipEmptyPositions=!1,this.fitWidth=!1,this.positionWidth=16,this.positionHeight=k.ES.Entropy,this.filterSource=k.vS.filterSource}};var G=s(833);const F=R;var H,V;!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(H||(H={})),function(t){t.skipEmptyPositions="skipEmptyPositions",t.regionTypes="regionTypes",t.chains="chains",t.fitWidth="fitWidth",t.positionWidth="positionWidth",t.positionHeight="positionHeight",t.filterSource="filterSource"}(V||(V={}));const W=P;class D extends o.JsViewer{constructor(){super(),this.viewed=!1,this.regionsFg=null,this.regionsRoot=null,this.isOpened=!1,this.panelNode=null,this.regions=[],this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.host=null,this.mainLayout=null,this.logos=[],this.viewSubs=[],this.calcSizeRequested=!1,this.skipEmptyPositions=this.bool(V.skipEmptyPositions,W.skipEmptyPositions,{category:H.DATA}),this.regionTypes=this.stringList(V.regionTypes,W.regionTypes,{category:H.DATA,choices:Object.values(F).filter((t=>t!=F.Unknown))}),this.chains=this.stringList(V.chains,W.chains,{category:H.DATA,choices:["Heavy","Light"]}),this.fitWidth=this.bool(V.fitWidth,W.fitWidth,{category:H.LAYOUT}),this.positionWidth=this.float(V.positionWidth,W.positionWidth,{category:H.LAYOUT,editor:"slider",min:0,max:64,description:"Internal WebLogo viewers property width of position."}),this.positionHeight=this.string(V.positionHeight,W.positionHeight,{category:H.LAYOUT,choices:Object.keys(k.ES)}),this.filterSource=this.string(V.filterSource,W.filterSource,{category:H.BEHAVIOR,choices:Object.values(k.Ct)})}async init(){this.subs.push((0,O.fromEvent)(this.root,"mousemove").subscribe(this.rootOnMouseMove.bind(this)))}detach(){const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.setDataInProgress||(this.viewed&&(await this.destroyView("detach"),this.viewed=!1),t())}))}onTableAttached(){super.onTableAttached(),this.setData(this.regions)}onPropertyChanged(t){if(super.onPropertyChanged(t),t){switch(t.name){case V.regionTypes:case V.chains:this.setData(this.regions)}switch(t.name){case V.skipEmptyPositions:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[G.bo.skipEmptyPositions]:this.skipEmptyPositions});this.calcSize();break;case V.fitWidth:case V.positionWidth:this.calcSize();break;case V.positionHeight:for(let t=0;t<this.logos.length;++t)for(const e of this.chains)this.logos[t][e].setOptions({[G.bo.positionHeight]:this.positionHeight});this.calcSize();break;case V.filterSource:this.filterSourceInput.value=this.filterSource;break;default:this.setData(this.regions)}}else console.warn("Bio: VdRegionsViewer.onPropertyChanged() property is null")}setData(t){Ke.logger.debug(`Bio: VdRegionsViewer.setData(), in, regions.length = ${t.length}`),this.viewPromise=this.viewPromise.then((async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(await this.destroyView("setData"),this.viewed=!1),await this.detachPromise,this.regions=t,this.viewed||(await this.buildView("setData"),this.viewed=!0)}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ke.logger.error(e,void 0,s)}finally{this.setDataInProgress=!1}}}))}async destroyView(t){Ke.logger.debug(`Bio: VdRegionsViewer.destroyView( mainLayout = ${this.mainLayout?"value":"none"} ), purpose = '${t}', this.regions.length = ${this.regions.length}`),this.filterSourceInput&&n.empty(this.filterSourceInput.root),null!=this.mainLayout&&(this.mainLayout.remove(),this.host.remove(),this.host=null,this.mainLayout=null);for(const t of this.viewSubs)t.unsubscribe()}async buildView(t){Ke.logger.debug(`Bio: VdRegionsViewer.buildView() begin, purpose = '${t}', this.regions.length = ${this.regions.length}`);const e=this.regions.filter((t=>this.regionTypes.includes(t.type))),s=Array.from(new Set(e.map((t=>t.order)))).sort(),i=[];for(let t=0;t<s.length;t++)for(const n of this.chains){const o=e.find((e=>e.order==s[t]&&e.chain==n));i.push((async()=>{const e=await this.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:o.sequenceColumnName,startPositionName:o.positionStartName,endPositionName:o.positionEndName,fixWidth:!0,skipEmptyPositions:this.skipEmptyPositions,positionWidth:this.positionWidth,positionHeight:this.positionHeight,filterSource:this.filterSource});return e.onSizeChanged.subscribe((()=>{this.calcSize()})),[t,n,e]})())}const o=await Promise.all(i);this.logos=new Array(s.length);for(let t=0;t<s.length;++t)this.logos[t]={};for(const[t,e,s]of o)this.logos[t][e]=s,this.viewSubs.push(s.onFreqsCalculated.subscribe((()=>{this.calcSize()})));this.mainLayout=n.table(this.chains,(t=>[...s.length>0?[n.div(t,{style:{transform:"rotate(-90deg)",font:"12px Roboto, Roboto Local, sans-serif",textAlign:"center",width:"16px",marginTop:"24px",marginLeft:"6px"}})]:[],...[...Array(s.length).keys()].map((e=>{const s=this.logos[e][t];return s.root.style.height="100%",n.div([s.root],{style:{marginTop:"4px",marginBottom:"4px"}})}))]),["",...[...Array(s.length).keys()].map((t=>e.find((e=>e.order==s[t]&&e.chain==this.chains[0])).name||"Name"))]),this.mainLayout.className="mlb-vd-regions-viewer-table2",this.filterSourceInput=n.choiceInput("Data source",this.filterSource,Object.values(k.Ct),this.filterSourceInputOnValueChanged.bind(this)),this.filterSourceInput.root.style.position="absolute",this.filterSourceInput.root.style.right="9px",this.filterSourceInput.root.style.top="-4px",Math.ceil(255*Math.random()).toString(16),this.host=n.div([this.mainLayout,this.filterSourceInput.root],{}),this.root.appendChild(this.host),this.root.style.overflowX="auto",this.calcSize(),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),Ke.logger.debug("Bio: VdRegionsViewer.buildView() end")}calcSize(){Ke.logger.debug("Bio: VdRegionsViewer.calcSize(), start");const t=()=>{if(!this.host)return;const t=(this.root.clientHeight-54)/this.chains.length;let e=0;for(let s=0;s<this.logos.length;s++){for(const e of this.chains)this.logos[s][e].root.style.height=`${t}px`;e+=Math.max(...this.chains.map((t=>this.logos[s][t].Length)))}if(this.fitWidth){if(this.logos.length>0&&e>0){const t=22,s=13,i=9,n=(this.root.clientWidth-t-(this.logos.length-1)*i-s)/e;for(let t=0;t<this.logos.length;t++)for(const e of this.chains){const s=this.logos[t][e];s.setOptions({[G.bo.positionWidth]:n-s.positionMarginValue}),s.root.style.width=n*s.Length+"px"}}this.host.style.setProperty("overflow","hidden","important")}else{for(let t=0;t<this.logos.length;t++)for(const e of this.chains)this.logos[t][e].setOptions({[G.bo.positionWidth]:this.positionWidth});this.host.style.removeProperty("overflow")}0===this.positionWidth?this.host.style.setProperty("overflow-x","hidden","important"):this.host.style.removeProperty("overflow-x")};this.calcSizeRequested||(this.calcSizeRequested=!0,window.setTimeout((()=>{t(),this.calcSizeRequested=!1}),0))}rootOnSizeChanged(t){this.calcSize()}rootOnMouseMove(t){}filterSourceInputOnValueChanged(){const t=this.filterSourceInput.value;this.viewPromise=this.viewPromise.then((()=>{if(this.filterSource!==t){this.props.getProperty(V.filterSource).set(this,t);for(let t=0;t<this.logos.length;t++)for(let e=0;e<this.chains.length;e++){const s=this.chains[e];this.logos[t][s].setOptions({[G.bo.filterSource]:this.filterSource})}}}))}}var B=s(9017),U=s(850);const Z="dimensionality-reducer-terminate-event";async function Y(t,e,n,o,r,a){const l=await async function(t,e,n,o,r){return new Promise((function(a,l){const h=new Worker(new URL(s.p+s.u(196),s.b));h.postMessage({columnData:t.data,method:e,measure:t.metric,options:n,parallelDistanceWorkers:o});const c=i.events.onCustomEvent(Z).subscribe((()=>{try{h?.terminate()}finally{c.unsubscribe()}}));h.onmessage=({data:{error:t,distance:e,embedding:s,epochNum:i,epochsLength:n}})=>{i&&n?r&&r(i,n,s):(c.unsubscribe(),t?l(t):a({distance:e,embedding:s}),setTimeout((()=>h.terminate()),0))}}))}({data:t,metric:n},e,o,r,a);return l.embedding=l.embedding.map((t=>(0,U.Fv)(t))),l}var z=s(7983),q=s(7228),$=s(489);async function X(t,e){const s=C.Cn.getOrCreate(t.seqCol),i=t.seqCol.toList(),n=s.getSplitter(),r=i.length;let a=36;const l=new Map;for(let e=0;e<r;e++){const s=i[e];if(null===i[e]||t.seqCol.isNone(e)){i[e]=null;continue}i[e]="";const o=n(s);for(let t=0;t<o.length;t++){const s=o[t];l.has(s)||(l.set(s,String.fromCharCode(a)),a++),i[e]+=l.get(s)}}if(t.similarityMetric===$.U.MONOMER_CHEMICAL_DISTANCE){const e=Array.from(l.keys()),s=await(0,q.PF)(e);s.scoringMatrix.forEach(((t,e)=>{t.forEach(((t,i)=>{s.scoringMatrix[e][i]=1-t}))}));const i={};Object.entries(s.alphabetIndexes).forEach((([t,e])=>{i[l.get(t)]=e})),t.options.distanceFnArgs={scoringMatrix:s.scoringMatrix,alphabetIndexes:i}}const h=await Y(i,t.methodName,t.similarityMetric,t.options,!0,e),c=t.embedAxesNames.map(((t,e)=>o.Column.fromFloat32Array(t,h.embedding[e])));return{distance:h.distance,coordinates:new o.ColumnList(c)}}function K(t){const e=["Embed_X","Embed_Y"],s=t.columns.names().filter((t=>t.includes(e[0]))).length+1;return e.map((t=>`${t}_${s}`))}var j=s(5697),J=s(3379),Q=s.n(J),tt=s(7795),et=s.n(tt),st=s(569),it=s.n(st),nt=s(3565),ot=s.n(nt),rt=s(9216),at=s.n(rt),lt=s(4589),ht=s.n(lt),ct=s(9414),ut={};ut.styleTagTransform=ht(),ut.setAttributes=ot(),ut.insert=it().bind(null,"head"),ut.domAPI=et(),ut.insertStyleElement=at(),Q()(ct.Z,ut),ct.Z&&ct.Z.locals&&ct.Z.locals;var mt=s(3914),dt=s(6254);let gt=0;const pt="cliffsDf",ft=new O.Subject,yt="act_diff",bt="sali",wt="sim",Ct="line_index",vt=["1_seq","2_seq"],St="filterCliffs";function Tt(t,e,s){const i=e.getBoundingClientRect(),n=t.clientX-i.left,o=t.clientY-i.top;let r=null,a=0;for(const t of s){const e=Math.abs(Math.hypot(t.a[0]-n,t.a[1]-o)+Math.hypot(t.b[0]-n,t.b[1]-o)-Math.hypot(t.a[0]-t.b[0],t.a[1]-t.b[1]));(!a&&e<2||e<a)&&(a=e,r=t)}return r}var Mt=s(6361);async function At(t,e,s,n,r){e.version!==e.temp["last-invalidated-version"]&&await(0,z.HV)(e,!1);const a=o.DataFrame.create(e.length);return a.columns.addNewString(n).init((t=>e.temp["monomeric-mols"].get(t))),await i.functions.call("Chem:getChemSimilaritiesMatrix",{dim:t,col:e.temp["monomeric-mols"],df:a,colName:n,simArr:r})}function Et(t){const e=n.divH([]),s=n.divV([n.divText(t.seqCol.name),n.divText(t.activityCol.name)]);return s.style.fontWeight="bold",s.style.display="flex",s.style.justifyContent="space-between",e.append(s),t.line.mols.forEach(((s,i)=>{const o=n.divText(t.activityCol.get(s).toFixed(2));o.style.display="flex",o.style.justifyContent="left",o.style.paddingLeft="30px",e.append(n.divV([n.divText(t.seqCol.get(s)),o]))})),e}function xt(t){const e=n.div();e.append(n.divText(t.seqCol.name,{style:{fontWeight:"bold"}}));const s=new Array(2),i=new Array(2);t.line.mols.forEach(((e,n)=>{s[n]=t.seqCol.get(e),i[n]=t.activityCol.get(e)}));const o={},r=C.Cn.getOrCreate(t.seqCol),a=r.getSplitter(),l=Nt(a(s[0]),a(s[1]),r.units,o);return e.append(n.div(l,{style:{width:"300px",overflow:"scroll"}})),e.append(Lt(o)),e.append(It("Activity delta",Math.abs(i[0]-i[1]))),e.append(It("Cliff",t.sali)),e}function It(t,e){return n.divH([n.divText(`${t}: `,{style:{fontWeight:"bold",paddingRight:"5px"}}),n.divText(e.toFixed(2))],{style:{paddingTop:"10px"}})}function Nt(t,e,s,i){const n=document.createElement("canvas"),o=n.getContext("2d");return n.height=30,L(o,0,0,0,30,t,e,s,!0,i),n}function Lt(t){const e=n.div();if(Object.keys(t).length>0){const s=n.divV([]);s.append(n.divH([n.divText("Pos",{style:{fontWeight:"bold",width:"30px",borderBottom:"1px solid"}}),n.divText("Difference",{style:{fontWeight:"bold",borderBottom:"1px solid"}})]));for(const e of Object.keys(t))t[e].style.borderBottom="1px solid lightgray",s.append(n.divH([n.divText((parseInt(e)+1).toString(),{style:{width:"30px",borderBottom:"1px solid lightgray"}}),t[e]]));e.append(s)}return e}function _t(t,e){const s=o.Column.string("seq_diff",t.rowCount).init((s=>`${t.get(e[0],s)}#${t.get(e[1],s)}`));s.semType="MacromoleculeDifference",s.setTag(o.TAGS.UNITS,t.col(e[0]).getTag(o.TAGS.UNITS)),s.setTag("separator",t.col(e[0]).getTag("separator")),t.columns.add(s);const i=t.plot.grid();return i.col(e[0]).visible=!1,i.col(e[1]).visible=!1,i}var Rt=s(4004),Ot=s(8601),kt=s(5226);s(9133);class Pt extends o.JsViewer{constructor(t){super(),this.name="",this.metricsProperties=["distanceMetric","fingerprint"],this.fingerprintChoices=["Morgan","Pattern"],this.initialized=!1,this.tags=[o.TAGS.UNITS,"aligned","separator","alphabet"],this.preComputeDistanceMatrix=!1,this.renderPromise=Promise.resolve(),this.fingerprint=this.string("fingerprint",this.fingerprintChoices[0],{choices:this.fingerprintChoices}),this.limit=this.int("limit",10),this.distanceMetric=this.string("distanceMetric",j.kg[0],{choices:j.kg}),this.moleculeColumnName=this.string("moleculeColumnName"),this.name=t}init(){this.initialized=!0}detach(){this.subs.forEach((t=>t.unsubscribe()))}async onTableAttached(){if(this.init(),this.dataFrame){this.preComputeDistanceMatrix=this.dataFrame.rowCount<=22e3,this.subs.push(o.debounce(this.dataFrame.onRowsRemoved,50).subscribe((t=>this.render(!0))));const t="diversity"!==this.name;this.subs.push(o.debounce(this.dataFrame.onCurrentRowChanged,50).subscribe((e=>this.render(t)))),this.subs.push(o.debounce(this.dataFrame.selection.onChanged,50).subscribe((t=>this.render(!1)))),this.subs.push(o.debounce(n.onSizeChanged(this.root),50).subscribe((t=>this.render(!1)))),this.moleculeColumn=this.dataFrame.columns.bySemType(o.SEMTYPE.MACROMOLECULE),this.moleculeColumnName=this.moleculeColumn?.name,this.getProperty("limit").fromOptions({min:1,max:this.dataFrame.rowCount})}this.render()}onPropertyChanged(t){if(super.onPropertyChanged(t),this.initialized){if("moleculeColumnName"===t.name){const e=this.dataFrame.col(t.get(this));e.semType===o.SEMTYPE.MACROMOLECULE&&(this.moleculeColumn=e)}this.render()}}render(t=!0){this.renderPromise=this.renderPromise.then((async()=>{this.computeRequested=this.computeRequested||t,await this.renderInt(t)}))}async renderInt(t){}beforeRender(){return!(!this.initialized||this.dataFrame&&this.moleculeColumnName&&this.dataFrame.col(this.moleculeColumnName).semType!==o.SEMTYPE.MACROMOLECULE&&(i.shell.error(`${this.moleculeColumnName} is not Macromolecule type`),1))}}var Gt=s(7241),Ft=s(4293),Ht=s(2669);async function Vt(t){const e=t.toList();if(t.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const s=C.Cn.getOrCreate(t).getDistanceFunctionName(),i=new Ht.m(!0,!1),n=await i.calc(e,s);return i.terminate(),n}function Wt(t){return(e,s)=>{const i=(e,s)=>t*e+s-Math.floor((e+2)*(e+1)/2);return e<=s?i(e,s):i(s,e)}}class Dt extends Pt{constructor(){super("similarity"),this.sketchedMolecule="",this.curIdx=0,this.molCol=null,this.idxs=null,this.scores=null,this.gridSelect=!1,this.targetMoleculeIdx=0,this.computeCompleted=new O.Subject,this.distanceMatrixComputed=!1,this.cutoff=this.float("cutoff",.01,{min:0,max:1}),this.hotSearch=this.bool("hotSearch",!0),this.similarColumnLabel=this.string("similarColumnLabel",null)}init(){this.hotSearch=!0,this.initialized=!0}async renderInt(t){if(this.beforeRender()&&this.moleculeColumn&&(this.curIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx,t&&!this.gridSelect)){this.targetMoleculeIdx=-1==this.dataFrame.currentRowIdx?0:this.dataFrame.currentRowIdx;const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.similarColumnLabel?this.similarColumnLabel:`similar (${this.moleculeColumnName})`;this.molCol=o.Column.string(e,this.idxs.length).init((t=>this.moleculeColumn?.get(this.idxs?.get(t)))),this.molCol.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>this.molCol.setTag(t,this.moleculeColumn.getTag(t))));const s=o.DataFrame.fromColumns([this.idxs,this.molCol,this.scores]);s.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=s.col("indexes").get(s.currentRowIdx),setTimeout((()=>{this.createPropertyPanel(s)}),1e3),this.gridSelect=!0}));const n=s.plot.grid();n.col("indexes").visible=!1;const r=this.idxs?.getRawData().findIndex((t=>t==this.targetMoleculeIdx));n.cell("score",r).cell.value=null,i.shell.v.grid.root.addEventListener("click",(t=>{this.gridSelect=!1})),(0,Ft.Y)(this.root,n.root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Gt.D)(this.moleculeColumn),e=(o.DataFrame.fromColumns([t]),await i.functions.call("Chem:callChemSimilaritySearch",{df:this.dataFrame,col:t,molecule:t.get(this.targetMoleculeIdx),metricName:this.distanceMetric,limit:this.limit,minScore:this.cutoff,fingerprint:this.fingerprint}));this.idxs=e.getCol("indexes"),this.scores=e.getCol("score")}async computeByMM(){let t=new Float32Array;!this.distanceMatrixComputed&&this.preComputeDistanceMatrix?(this.mmDistanceMatrix=await Vt(this.moleculeColumn),this.distanceMatrixComputed=!0):this.preComputeDistanceMatrix||(t=await async function(t,e){const i=t.toList();if(t.semType!==o.SEMTYPE.MACROMOLECULE)throw new Error("Column has to be of macromolecule type");const n=C.Cn.getOrCreate(t).getDistanceFunctionName(),r=Math.min(Math.max(navigator.hardwareConcurrency-2,1),i.length),a=new Array(r).fill(null).map((t=>new Worker(new URL(s.p+s.u(190),s.b)))),l=new Float32Array(i.length);let h=0,c=Number.MIN_VALUE;const u=a.map(((t,s)=>{const o=Math.floor(s*i.length/r),u=s===a.length-1?Math.floor((s+1)*i.length/r):i.length;return new Promise(((s,r)=>{t.onmessage=({data:{error:t,distanceArrayData:e,min:i,max:n}})=>{t?r(t):(h=Math.min(h,i),c=Math.max(c,n),l.set(e,o),s())},t.postMessage({fnName:n,values:i,templateIdx:e,start:o,end:u})}))}));try{await Promise.all(u),l.forEach(((t,e)=>{l[e]=(t-h)/(c-h)})),a.forEach((t=>t.terminate()))}catch(t){throw a.forEach((t=>t.terminate())),t}return l}(this.moleculeColumn,this.targetMoleculeIdx));const e=this.moleculeColumn.length,i=Wt(e),n=Array(e).fill(0).map(((e,s)=>({idx:s,score:s===this.targetMoleculeIdx?1:this.preComputeDistanceMatrix?1-this.mmDistanceMatrix[i(this.targetMoleculeIdx,s)]:1-t[s]})));n.sort(((t,e)=>e.score-t.score));const r=Math.min(this.limit,e),a=n.slice(0,r);this.idxs=o.Column.int("indexes",r).init((t=>a[t].idx)),this.scores=o.Column.float("score",r).init((t=>a[t].score))}createPropertyPanel(t){const e=n.div(),s={},o=this.molCol?.name,r=t.col(o),a=C.Cn.getOrCreate(r),l=a.getSplitter(),h=l(this.moleculeColumn.get(this.targetMoleculeIdx)),c=l(t.get(o,t.currentRowIdx)),u=Nt(h,c,a.units,s);e.append(n.div(u,{style:{width:"300px",overflow:"scroll"}})),h.length!==c.length&&e.append(n.divV([n.divText("Different sequence length:",{style:{fontWeight:"bold"}}),n.divText(`target: ${h.length} monomers`),n.divText(`selected: ${c.length} monomers`)],{style:{paddingBottom:"10px"}})),e.append(Lt(s));const m=n.accordion(),d=n.element("i");d.className="grok-icon svg-icon svg-view-layout",m.addTitle(n.span([d,n.label("Similarity search")])),m.addPane("Differences",(()=>e),!0),i.shell.o=m.root}}var Bt=s(8518);class Ut extends Pt{constructor(){super("diversity"),this.renderMolIds=null,this.columnNames=[],this.computeCompleted=new O.Subject,this.diverseColumnLabel=this.string("diverseColumnLabel",null)}async renderInt(t){if(this.beforeRender()&&this.dataFrame&&t&&this.moleculeColumn){const t=C.Cn.getOrCreate(this.moleculeColumn);await(t.isFasta()?this.computeByMM():this.computeByChem());const e=null!=this.diverseColumnLabel?this.diverseColumnLabel:`diverse (${this.moleculeColumnName})`,s=o.Column.string(e,this.renderMolIds.length).init((t=>this.moleculeColumn?.get(this.renderMolIds[t])));s.semType=o.SEMTYPE.MACROMOLECULE,this.tags.forEach((t=>s.setTag(t,this.moleculeColumn.getTag(t))));const i=o.DataFrame.fromColumns([s]);i.onCurrentRowChanged.subscribe((t=>{this.dataFrame.currentRowIdx=this.renderMolIds[i.currentRowIdx]})),(0,Ft.Y)(this.root,i.plot.grid().root),this.computeCompleted.next(!0)}}async computeByChem(){const t=await(0,Gt.D)(this.moleculeColumn);o.DataFrame.fromColumns([t]),this.renderMolIds=await i.functions.call("Chem:callChemDiversitySearch",{col:t,metricName:this.distanceMetric,limit:this.limit,fingerprint:this.fingerprint})}async computeByMM(){const t=await Vt(this.moleculeColumn),e=this.moleculeColumn.length,s=Wt(e);this.renderMolIds=(0,Bt.L)(e,Math.min(e,this.limit),((e,i)=>this.moleculeColumn.isNone(e)||this.moleculeColumn.isNone(i)?0:t[s(e,i)]))}}var Zt=s(9943),Yt=s(4413),zt=s(1061),qt=s(5490),$t=s(116),Xt=s(1040);const Kt={[o.SEMTYPE.MOLECULE]:"Molecules",[o.SEMTYPE.MACROMOLECULE]:"Sequences"};class jt{get algorithmOptions(){const t=this.methodsParams[this.methodInput.value],e={};return Object.keys(t).forEach((s=>{null!=t[s].value&&(e[s]=t[s].value)})),e}constructor(t){this.methodSettingsDiv=n.inputs([]),this.methodsParams={[$t.AL.UMAP]:new $t.bD,[$t.AL.T_SNE]:new $t.aP},this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged(t)})),this.molColInput=n.columnInput(Kt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t),null,{filter:e=>e.semType===t}),this.molColInputRoot=this.molColInput.root,this.molColInput.onChanged((()=>this.onColumnInputChanged(t))),this.methodInput=n.choiceInput("Method",$t.AL.UMAP,[$t.AL.UMAP,$t.AL.T_SNE],(()=>{e&&this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]),this.displaySimilarityThresholdInput(t)})),this.similarityThresholdInput=n.floatInput("Similarity threshold",.5),n.tooltip.bind(this.similarityThresholdInput.root,"Similarity threshold for sparse matrix creation."),this.methodSettingsIcon=n.icons.settings((()=>{e=!e,e?this.createAlgorithmSettingsDiv(this.methodSettingsDiv,this.methodsParams[this.methodInput.value]):n.empty(this.methodSettingsDiv)}),"Modify methods parameters"),this.methodInput.root.classList.add("ml-dim-reduction-settings-input"),this.methodInput.root.prepend(this.methodSettingsIcon),this.methodSettingsDiv=n.inputs([]);let e=!1;this.similarityMetricInput=t===o.SEMTYPE.MOLECULE?n.choiceInput("Similarity",Xt.gk.Tanimoto,j.Rt):n.choiceInput("Similarity",$.U.HAMMING,j.bc),setTimeout((()=>{this.displaySimilarityThresholdInput(t),this.onColumnInputChanged(t)}))}createAlgorithmSettingsDiv(t,e){return n.empty(t),Object.keys(e).forEach((s=>{const i=e[s],o=n.floatInput(i.uiName,i.value,(()=>{i.value=o.value}));n.tooltip.bind(o.root,i.tooltip),t.append(o.root)})),t}onTableInputChanged(t){this.molColInput=n.columnInput(Kt[t],this.tableInput.value,this.tableInput.value.columns.bySemType(t)),this.molColInput.onChanged((()=>this.onColumnInputChanged(t))),n.empty(this.molColInputRoot),Array.from(this.molColInput.root.children).forEach((t=>this.molColInputRoot.append(t))),this.displaySimilarityThresholdInput(t),this.onColumnInputChanged(t)}onColumnInputChanged(t){const e=this.molColInput.value;if(!e||t!==o.SEMTYPE.MACROMOLECULE)return;const s=(e.getTag("aligned")??" ").toUpperCase().includes("MSA");this.similarityMetricInput.value=s?$.U.HAMMING:$.U.LEVENSHTEIN}displaySimilarityThresholdInput(t){t!==o.SEMTYPE.MOLECULE&&this.tableInput.value&&this.tableInput.value.rowCount>2e4&&this.methodInput.value===$t.AL.UMAP?this.similarityThresholdInput.root.style.display="block":this.similarityThresholdInput.root.style.display="none"}}class Jt extends jt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,sparseMatrixThreshold:this.similarityThresholdInput.value??.8,plotEmbeddings:this.plotEmbeddingsInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t),this.plotEmbeddingsInput=n.boolInput("Plot embeddings",!0),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.methodInput,this.similarityThresholdInput,this.methodSettingsDiv,this.similarityMetricInput,this.plotEmbeddingsInput],{style:{minWidth:"320px"}})}}class Qt extends jt{get funcParams(){return{table:this.tableInput.value,molecules:this.molColInput.value,activities:this.activitiesInput.value,similarity:this.similarityInput.value,methodName:this.methodInput.value,similarityMetric:this.similarityMetricInput.value,options:this.algorithmOptions}}get paramsUI(){return this.funcParamsDiv}constructor(t){super(t);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,o.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),this.activitiesInputRoot=this.activitiesInput.root,this.similarityInput=n.intInput("Similarity cutoff",80),n.tooltip.bind(this.similarityInput.root,"Pairs of similar (cutoff is used) molecules with high difference in activity are considered 'cliffs'"),this.funcParamsDiv=n.inputs([this.tableInput,this.molColInput,this.activitiesInput,this.similarityInput,this.methodInput,this.methodSettingsDiv,this.similarityMetricInput],{style:{minWidth:"320px"}})}onTableInputChanged(t){super.onTableInputChanged(t),n.empty(this.activitiesInputRoot);const e=this.tableInput.value.columns.numerical;this.activitiesInput=n.columnInput("Activities",this.tableInput.value,o.Utils.firstOrNull(e),null,{filter:t=>Array.from(e).includes(t)}),Array.from(this.activitiesInput.root.children).forEach((t=>this.activitiesInputRoot.append(t)))}}var te,ee=s(8457);async function se(t,e,s,i){const n=(0,ee.O)(e),r=(0,l.vU)(e.getTag(o.TAGS.UNITS),e.getTag("separator"))(s),a=i===te.IDENTITY?function(t,e){const s=e.columns.length,i=new Array(s),n=new Array(s),r=new Array(s);for(let o=0;o<s;++o){const s=e.columns.byIndex(o);i[o]=s.getRawData(),n[o]=s.categories.indexOf(""),r[o]=s.categories.indexOf(t[o]??"")}const a=o.Column.float("Identity",e.rowCount),l=a.getRawData();for(let s=0;s<e.rowCount;++s){l[s]=0;for(let e=0;e<t.length;++e)i[e][s]===r[e]&&++l[s];l[s]/=t.length}return a}(r,n):i===te.SIMILARITY?await async function(t,e){const s=e.columns.toList();return await(0,q.Qx)(s,t)}(r,n):null;if(null===a)throw new Error(`In bio library: Unkown sequence scoring method: ${i}`);return a.name=t.columns.getUnusedName(a.name),t.columns.add(a),a}!function(t){t.IDENTITY="identity",t.SIMILARITY="similarity"}(te||(te={}));var ie,ne=function(t,e,s,i){return new(s||(s=Promise))((function(n,o){function r(t){try{l(i.next(t))}catch(t){o(t)}}function a(t){try{l(i.throw(t))}catch(t){o(t)}}function l(t){var e;t.done?n(t.value):(e=t.value,e instanceof s?e:new s((function(t){t(e)}))).then(r,a)}l((i=i.apply(t,e||[])).next())}))};class oe{constructor(t,e,s=!1,i){var o;this.name="",this.description="",this._isAutomatic=!1,this._autoStartFirstStep=!1,this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._isStepProcessed=!1,this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._steps=[],this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._stopStartBtn=n.button(n.iconFA("pause"),(()=>this._changeStopState()),"Play / pause"),this._restartBtn=n.button(n.iconFA("redo"),(()=>this._restartScript()),"Restart"),this._nextStepBtn=n.button(n.iconFA("play"),(()=>{this._isStepProcessed||this._nextStep()}),"Next step"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._closeBtn=n.button(n.iconFA("chevron-left"),(()=>this._closeDock()),"Back to demo"),this.name=t,this.description=e,this._isAutomatic=s,this._autoStartFirstStep=null!==(o=null==i?void 0:i.autoStartFirstStep)&&void 0!==o&&o,this._progress.max=0,this._progress.value=1,oe.currentObject=this}get steps(){return this._steps}get stepNumber(){return this._steps.length}_addHeader(){this._createHeaderDiv(),this._createProgressDiv(),this._mainHeader.append(this._headerDiv,this._progressDiv)}_createHeaderDiv(){this._header.innerText=this.name,this._headerDiv.append(this._closeBtn),this._headerDiv.append(this._header),this._nextStepBtn.firstChild.className="grok-icon fas fa-play",this._headerDiv.append(this._isAutomatic?this._stopStartBtn:this._nextStepBtn)}_createProgressDiv(){this._progress.max=this.stepNumber,this._progressDiv.append(this._progress),this._progressSteps=n.divText(`Step: ${this._progress.value} of ${this.stepNumber}`),this._progressDiv.append(this._progressSteps)}_addDescription(){var t;this._activity.append(n.div(this.description,"tutorials-root-description"));for(let e=0;e<this.stepNumber;e++){let s=n.iconFA("clock");this._isAutomatic||0===e&&(s=n.iconFA("play",(()=>this._nextStep()),"Next step"),s.className="grok-icon fas fa-play");const i=n.div(this._steps[e].name,"grok-tutorial-entry-instruction"),o=n.div(null===(t=this._steps[e].options)||void 0===t?void 0:t.description,"grok-tutorial-step-description hidden"),r=n.divH([s,i],"grok-tutorial-entry");this._activity.append(r,o)}}_initRoot(){var t,e,s;i.shell.windows.showContextPanel=!0,i.shell.windows.showHelp=!1;const n=Array.from(i.shell.dockManager.rootNode.children)[0];this._node=i.shell.dockManager.dock(this._root,o.DOCK_TYPE.FILL,n,""),(null===(e=null===(t=n.parent.container.containerElement.firstElementChild)||void 0===t?void 0:t.lastElementChild)||void 0===e?void 0:e.classList.contains("tab-handle-list-container"))&&(null===(s=n.parent.container.containerElement.firstElementChild)||void 0===s||s.lastElementChild.remove()),this._node.container.containerElement.classList.add("tutorials-demo-script-container"),this._addHeader(),this._root.append(this._mainHeader),this._addDescription(),this._root.append(this._activity)}_nextStep(){var t,e;return ne(this,void 0,void 0,(function*(){this._isStepProcessed=!0,this._isAutomatic||(this._nextStepBtn.classList.add("disabled"),this._nextStepBtn.firstChild.classList.add("fa-disabled"));const s=this._activity.getElementsByClassName("grok-tutorial-entry")[this._currentStep],i=this._activity.getElementsByClassName("grok-icon")[this._currentStep],o=this._activity.getElementsByClassName("grok-tutorial-step-description")[this._currentStep];i.className="grok-icon far fa-spinner-third fa-spin",o.classList.remove("hidden"),o.classList.add("visible");const r=s,a=(null===(t=this._steps[this._currentStep].options)||void 0===t?void 0:t.delay)?null===(e=this._steps[this._currentStep].options)||void 0===e?void 0:e.delay:2e3;yield this._steps[this._currentStep].func(),this._scrollTo(this._root,r.offsetTop-this._mainHeader.offsetHeight),this._isAutomatic&&(yield this._countdown(s,i,a),yield(0,zt.gw)(a));const l=n.iconFA("check");if(i.replaceWith(l),l.className="grok-icon far fa-check",this._progress.value++,this._progressSteps.innerText=`Step: ${this._progress.value} of ${this.stepNumber}`,this._currentStep++,this._isStepProcessed=!1,this._currentStep!==this.stepNumber){if(!this._isAutomatic){const t=this._activity.getElementsByClassName("grok-icon")[this._currentStep],e=n.iconFA("play",(()=>this._nextStep()),"Next step");e.className="grok-icon fas fa-play",t.replaceWith(e),this._nextStepBtn.classList.remove("disabled"),this._nextStepBtn.firstChild.classList.remove("fa-disabled")}}else this._isAutomatic?this._stopStartBtn.replaceWith(this._restartBtn):this._nextStepBtn.replaceWith(this._restartBtn)}))}_startScript(){return ne(this,void 0,void 0,(function*(){for(let t=this._currentStep;t<this.stepNumber&&!this._isStopped&&!this._isCancelled;t++)yield this._nextStep()}))}_scrollTo(t,e){t.focus(),t.scrollTop=e}_countdown(t,e,s){return ne(this,void 0,void 0,(function*(){const i=n.div([],"demo-script-countdown");e.classList.add("hidden");let o=s/1e3;const r=this._createSVGIndicator(o);i.append(r),t.prepend(i);const a=setInterval((()=>{o--,0===o&&(clearInterval(a),i.remove(),e.classList.remove("hidden"),e.classList.add("visible"))}),1e3)}))}_createSVGIndicator(t){const e=document.createElementNS("http://www.w3.org/2000/svg","svg"),s=document.createElementNS("http://www.w3.org/2000/svg","circle");return s.setAttributeNS(null,"cx","7"),s.setAttributeNS(null,"cy","7"),s.setAttributeNS(null,"r","6"),s.setAttributeNS(null,"style",`animation: countdown ${t}s linear infinite forwards`),e.append(s),e}_changeStopState(){const t=this._stopStartBtn.getElementsByClassName("grok-icon");t[0].className="grok-icon fas fa-play",this._isStopped=!this._isStopped,this._isStopped||(t[0].className="grok-icon fal fa-pause",this._isStepProcessed||this._startScript())}_restartScript(){i.shell.dockManager.close(this._node),i.shell.closeAll(),this._clearRoot(),this._setInitParams(),this.start()}_clearRoot(){this._root=n.div([],{id:"demo-script",classes:"tutorials-root tutorials-track demo-app-script"}),this._mainHeader=n.panel([],"tutorials-main-header"),this._header=n.h2(""),this._headerDiv=n.divH([],"tutorials-root-header"),this._activity=n.panel([],"tutorials-root-description"),this._progressDiv=n.divV([],"tutorials-root-progress"),this._progress=n.element("progress"),this._progressSteps=n.divText(""),this._progress.max=0,this._progress.value=1}_setInitParams(){this._currentStep=0,this._isStopped=!1,this._isCancelled=!1,this._stopStartBtn.getElementsByClassName("grok-icon")[0].className="grok-icon fal fa-pause",this._nextStepBtn.classList.remove("disabled")}_closeDock(){i.shell.dockManager.close(this._node),this.cancelScript()}cancelScript(){this._isCancelled=!0,oe.currentObject=null}step(t,e,s){return this._steps[this.steps.length]={name:t,func:e,options:s},this}start(){return ne(this,void 0,void 0,(function*(){this._initRoot(),i.shell.newView(this.name),this._isAutomatic?this._startScript():this._autoStartFirstStep&&(yield this._nextStep())}))}}function re(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),Ke.logger.error(t.message,void 0,s)}oe.currentObject=null,function(t){t.X="Embed_X",t.Y="Embed_Y"}(ie||(ie={}));const ae="data/sample_FASTA_PT_activity.csv";var le=s(1811);async function he(){const t="Dendrogram",e=o.Func.find({package:t,name:"getTreeHelper"});if(0===e.length)throw new Error(`Package "${t}" must be installed for TreeHelper.`);return(await e[0].prepare().call()).getOutputParamValue()}async function ce(){return await i.functions.call("Dendrogram:getDendrogramService",{})}const ue="data/sample_FASTA_PT_activity.csv",me="sequence";var de=s(3336),ge=s.n(de);const pe="data/sample_FASTA_PT_activity.csv";var fe=s(8341);const ye="samples/HELM.csv";var be=s(2568),we=s(525);class Ce{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.df=t,await this.buildView()}async buildView(){const t=a()(this.urlParams.entries()).map((([t,e])=>`${t}=${encodeURIComponent(e)}`)).toArray().join("&");this.view=i.shell.addTableView(this.df),this.view.path=this.view.basePath=`func/${Ke.name}.${this.funcName}?${t}`;const e={sequenceColumnName:"sequence"};for(const[t,s]of this.urlParams.entries())switch(t){case G.bo.fixWidth:case G.bo.fitArea:e[t]=["1","on","true"].includes(s.toLowerCase());break;default:e[t]=s}const s=await this.view.dataFrame.plot.fromType("WebLogo",e);this.view.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class ve{get funcParams(){return{table:this.tableInput.value,sequence:this.seqColInput.value}}get paramsUI(){return this.funcParamsDiv}constructor(){this.tableInput=n.tableInput("Table",i.shell.tv.dataFrame,void 0,(()=>{this.onTableInputChanged()}));const t=this.tableInput.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE),e={filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE};this.seqColInput=n.columnInput("Sequence",this.tableInput.value,t,null,e),this.funcParamsDiv=n.inputs([this.tableInput,this.seqColInput],{style:{minWidth:"320px"}})}onTableInputChanged(){this.seqColInput=n.columnInput("Sequence",this.tableInput.value,this.tableInput.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE))}}var Se=s(9416);class Te{constructor(t){this.monomerLib=t}getCappedRotatedMonomer(t,e){const s=this.monomerLib.getMonomer(t,e);return s?s.molfile:null}}const Me=new class{constructor(){this.tooltipHandlerTemp="tooltip-handler.Monomer"}},Ae={autoCrop:!0,autoCropMargin:0,suppressChiralText:!0};class Ee{constructor(t){this.gridCol=t,this.gridCol.grid.onCellTooltip(this.onCellTooltip.bind(this))}onCellTooltip(t,e,s){if(t.grid.dart!=this.gridCol.grid.dart||t.gridColumn.dart!=this.gridCol.dart||!t.tableColumn||!t.isTableCell)return!1;const o=t.tableColumn.getTag("alphabet"),r=t.cell.value,a="DNA"===o||"RNA"===o?"RNA":"PEPTIDE",l=new Te(Je().getBioLib()).getCappedRotatedMonomer(a,r),h=n.div(r),c=l?i.chem.svgMol(l,void 0,void 0,Ae):null,u=t.grid.canvas.getBoundingClientRect(),m=t.bounds.right+u.left-4,d=t.bounds.bottom+u.top-4;return n.tooltip.show(n.divV([h,...c?[c]:[]]),m,d),!0}static getOrCreate(t){let e=t.temp[Me.tooltipHandlerTemp];return e||(e=t.temp[Me.tooltipHandlerTemp]=new Ee(t)),e}}class xe extends o.GridCellRenderer{get name(){return S.Of.MONOMER}get cellType(){return S.Of.MONOMER}get defaultHeight(){return 15}get defaultWidth(){return 40}render(t,e,s,i,n,o,r){if(o.gridRow<0)return;Ee.getOrCreate(o.gridColumn),t.font="12px monospace",t.textBaseline="middle",t.textAlign="center";const a=(0,b.py)(o.cell.column.getTag("alphabet")),l=o.cell.value;if(!l)return;const h=a.get(l);t.fillStyle=h,t.fillText((0,b.GU)(l,6),e+i/2,s+n/2,i)}}class Ie extends Map{get onPropertyChanged(){return this._onPropertyChanged}get MaxMonomerLength(){return super.get("MaxMonomerLength")}set MaxMonomerLength(t){super.set("MaxMonomerLength",t),this._onPropertyChanged.next("MaxMonomerLength")}get TooltipWebLogo(){return super.get("TooltipWebLogo")}set TooltipWebLogo(t){super.set("TooltipWebLogo",t),this._onPropertyChanged.next("TooltipWebLogo")}get DefaultSeparator(){return super.get("DefaultSeparator")}set DefaultSeparator(t){if(1!==t.length)throw new Error("The separator must be of length one.");super.set("DefaultSeparator",t),this._onPropertyChanged.next("DefaultSeparator")}constructor(t){super(Object.entries(t)),this._onPropertyChanged=new O.Subject}}class Ne extends o.Package{constructor(){super(...arguments),this._initialized=!1}get properties(){return this._properties}set properties(t){this._properties=t}get initialized(){return this._initialized}completeInit(){this._initialized=!0}handleErrorUI(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(e),this.logger.error(e,void 0,s)}}class Le extends o.Widget{constructor(t){super(n.div([],{}));const e=Object.assign({},...t.map((t=>({[t.name]:t}))));this.maxMonomerLengthProp=e.MaxMonomerLength,this.tooltipWebLogo=e.TooltipWebLogo,this.defaultSeparator=e.DefaultSeparator}async init(){const t=n.intInput("Max monomer length",Ke.properties.MaxMonomerLength,(t=>{Ke.properties.MaxMonomerLength=t})),e=n.boolInput("Tooltip WebLogo",Ke.properties.TooltipWebLogo,(t=>{Ke.properties.TooltipWebLogo=t})),s=n.choiceInput("Default Separator",Ke.properties.DefaultSeparator,[".","/","-"],(t=>{Ke.properties.DefaultSeparator=t}));this.root.appendChild(n.form([t,e,s]))}}var _e=s(5362),Re={};Re.styleTagTransform=ht(),Re.setAttributes=ot(),Re.insert=it().bind(null,"head"),Re.domAPI=et(),Re.insertStyleElement=at(),Q()(_e.Z,Re),_e.Z&&_e.Z.locals&&_e.Z.locals;class Oe extends o.Widget{constructor(t){super(n.divV([])),this.viewed=!1,this.seqCol=t}async init(){const t=C.Cn.getOrCreate(this.seqCol),e=Ke.properties.TooltipWebLogo,s=this.seqCol.getTag(k.DX.tooltipWebLogo);!1===e||["false","off","disable","disabled"].includes(s)||(this.wlViewer=await this.seqCol.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.seqCol.name,backgroundColor:0,positionHeight:"Entropy",positionWidth:t.getAlphabetIsMultichar()?24:16,fixWidth:!0,fitArea:!1}),this.wlViewer.root.style.height="50px",this.root.appendChild(this.wlViewer.root),this.root.style.width="100%")}}const ke="PEPTIDE1{",Pe="}$$$$",Ge="<All>";function Fe(t){t.setTag("quality",o.SEMTYPE.MACROMOLECULE),t.setTag("aligned","SEQ"),t.setTag("alphabet","PT")}class He{constructor(t,e){this.helmColumn=t,this.leftTerminal=e.leftTerminal,this.rightTerminal=e.rightTerminal}transform(){return this.helmColumn.toList().map((t=>this.hasTerminals(t)?this.getTransformedHelm(t):t))}}class Ve extends He{constructor(t,e){super(t,e)}hasTerminals(t){return!!t.includes(this.rightTerminal+Pe)&&(this.leftTerminal===Ge||t.includes(ke+this.leftTerminal))}getLinkedPositions(t){return[1,Ue(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ze(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:3})}}class We extends He{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Ge||this.rightTerminal===Ge||t.includes(ke+this.leftTerminal)&&t.includes(this.rightTerminal+Pe)}getLinkedPositions(t){return[1,Ue(t)]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ze(t,{monomerPosition:e[0],attachmentPoint:1},{monomerPosition:e[1],attachmentPoint:2})}}class De extends He{constructor(t,e){super(t,e)}hasTerminals(t){return this.leftTerminal===Ge||this.rightTerminal===Ge||this.getLinkedPositions(t).every((t=>t>0))}getLinkedPositions(t){const e=t.replace(ke,"").replace(Pe,"").split("."),s=e.findIndex((t=>t===this.leftTerminal)),i=e.findIndex(((t,e)=>t===this.rightTerminal&&e>s));return[s+1,i+1]}getTransformedHelm(t){const e=this.getLinkedPositions(t);return Ze(t,{monomerPosition:e[0],attachmentPoint:3},{monomerPosition:e[1],attachmentPoint:3})}}class Be{constructor(){}static getInstance(t,e){const s=e.cyclizationType;return"R3-R3"===s?new De(t,e):"N-Cys"===s?new Ve(t,e):new We(t,e)}}function Ue(t){return t.replace(ke,"").replace(Pe,"").split(".").length}function Ze(t,e,s){return t.replace(Pe,`}$PEPTIDE1,PEPTIDE1,${e.monomerPosition}:R${e.attachmentPoint}-${s.monomerPosition}:R${s.attachmentPoint}${"$".repeat(6)}`)}async function Ye(t,e){const s=t.dataFrame,n=C.Cn.getOrCreate(t).convert(b.r2.HELM),r=Be.getInstance(n,e).transform(),a=s.columns.getUnusedName(`${e.transformationType}(`+t.name+")"),l=o.Column.fromList("string",a,r);Fe(l),l.setTag("units",b.r2.HELM),l.setTag("cell.renderer","helm"),s.columns.add(l),await i.data.detectSemanticTypes(s)}function ze(t,e,s,i){const n=C.Cn.getOrCreate(t);let o=null,r=null;for(let t=0;t<n.posList.length;++t)n.posList[t]==e&&(o=t),n.posList[t]==s&&(r=t);if(null===o&&null!==e)throw new Error(`Start position ${e} not found.`);if(null===r&&null!==s)throw new Error(`End position ${s} not found.`);if(n.posList.length<r)throw new Error(`End position ${r} exceeds positions length`);const a=i||`${t.name}: (${e??""}-${s??""})`;return n.getRegion(o,r,a)}const qe={df:o.DataFrame.fromCsv("seq,value\nATCCGTCGT,0.5\nTGTTCGTCA,0.4\nATGGTCGTA,0.7\nATCCGTGCA,0.1"),colName:"seq",positionNames:["1","1A","1C","2","4","4A","4B","5","6"].join(b.CI),regions:[{name:"first region",start:"1",end:"2"},{name:"second region",start:"1C",end:"4"},{name:"overlapping second",start:"1C",end:"4A"},{name:"whole sequence",start:"1",end:"6"},{name:"bad start",start:"0",end:"6"},{name:"bad end",start:"1",end:"4C"},{name:"bad start & end",start:"0",end:"4C"}]};class $e{constructor(t,e){this.urlParams=t,this.funcName=e}async init(t){this.data=t??qe;const e=this.data.df.getCol(this.data.colName);this.data.positionNames&&e.setTag(".positionNames",this.data.positionNames),this.data.regions&&e.setTag(".regions",JSON.stringify(this.data.regions)),await this.buildView()}async buildView(){await i.data.detectSemanticTypes(this.data.df),this.view=i.shell.addTableView(this.data.df),this.view.path=this.view.basePath=`func/${Ke.name}.${this.funcName}`;const t=await this.view.dataFrame.plot.fromType("WebLogo",{sequenceColumnName:this.data.colName});this.view.dockManager.dock(t,o.DOCK_TYPE.DOWN,null,"WebLogo",.35)}}class Xe{constructor(t){this.call=t,this.inputs=new class{},this.fixRegion=!1,this.defaultName=!0,this.defaultNameUpdating=!1;const e=t=>this.call.inputParams[t].property.description;this.inputs.table=n.tableInput("Table",this.call.inputParams.table.value??i.shell.tv.dataFrame,void 0,(()=>{}));const s=this.call.inputParams.sequence.value??this.inputs.table.value.columns.bySemType(o.SEMTYPE.MACROMOLECULE),r={filter:t=>t.semType===o.SEMTYPE.MACROMOLECULE};this.inputs.sequence=n.columnInput("Sequence",i.shell.tv.dataFrame,s,this.sequenceInputChanged.bind(this),r),this.inputs.start=n.choiceInput("Start",void 0,[],this.startInputChanged.bind(this)),this.inputs.end=n.choiceInput("End",void 0,[],this.endInputChanged.bind(this)),this.inputs.region=n.choiceInput("Region",null,[],this.regionInputChanged.bind(this)),this.inputs.name=n.stringInput("Column name",this.getDefaultName(),this.nameInputChanged.bind(this),{clearIcon:!0}),this.inputs.name.onInput(this.nameInputInput.bind(this));for(const t in this.call.inputParams)n.tooltip.bind(this.inputs[t].captionLabel,e(t));this.sequenceInputChanged()}sequenceInputChanged(){const t=this.inputs.sequence.value;t&&C.Cn.getOrCreate(t),this.updateRegionItems(),this.updateStartEndInputItems(),this.updateRegion(!0),this.updateNameInput()}regionInputChanged(){this.fixRegion=!0;try{const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null;if(null!==e)this.inputs.start.value=e?.start,this.inputs.end.value=e?.end;else{const t=C.Cn.getOrCreate(this.inputs.sequence.value);this.inputs.start.value=t.posList[0],this.inputs.end.value=t.posList[t.posList.length-1]}}finally{this.fixRegion=!1}}startInputChanged(){this.updateRegion(!1),this.updateNameInput()}endInputChanged(){this.updateRegion(!1),this.updateNameInput()}nameInputChanged(){this.defaultNameUpdating||(this.defaultName=!1)}nameInputInput(){this.inputs.name.value||(this.defaultName=!0,this.inputs.name.input.focus())}updateStartEndInputItems(){const t=this.inputs.sequence.value,e=t?C.Cn.getOrCreate(t):null,s=this.inputs.start.input,i=this.inputs.end.input;for(let t=s.options.length-1;t>=0;--t)s.options.remove(t);for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);for(const t of e?.posList??[]){const e=document.createElement("option"),n=document.createElement("option");e.text=n.text=t,e.value=n.value=t,s.options.add(e),i.options.add(n)}s.value=e?.posList[0]??"",i.value=e?.posList[e?.posList.length-1]??""}updateRegionItems(){const t=this.inputs.sequence.value,e=t?t.getTag(".regions"):null,s=e?JSON.parse(e):null,i=this.inputs.region.input;for(let t=i.options.length-1;t>=0;--t)i.options.remove(t);const n=document.createElement("option");if(n.text="",n.value=JSON.stringify(null),i.options.add(n),null!=s){this.inputs.region.root.style.removeProperty("display");for(const t of s){const e=document.createElement("option");e.text=`${t.name}: ${t.start}-${t.end}`,e.value=JSON.stringify(t),i.options.add(e)}}else this.inputs.region.root.style.display="none"}updateRegion(t){const e=this.inputs.start.stringValue??"",s=this.inputs.end.stringValue??"";if(!this.fixRegion){const t=this.inputs.region.input;t.selectedIndex=-1;for(let i=t.options.length-1;i>=0;--i){const n=t.options[i],o=JSON.parse(n.value);o&&e===o.start&&s===o.end&&(t.selectedIndex=i)}}}updateNameInput(){this.defaultNameUpdating=!0;try{this.defaultName&&(this.inputs.name.value=this.getDefaultName())}finally{this.defaultNameUpdating=!1}}getDefaultName(){const t=this.inputs.region.stringValue,e=t?JSON.parse(t):null,s=this.inputs.sequence.value,i=this.inputs.start.stringValue??"",n=this.inputs.end.stringValue??"";return null!=e?`${s.name}(${e.name}): ${e.start}-${e.end}`:`${s?.name}: (${i}-${n})`}getParams(){return{table:this.inputs.table.value,sequence:this.inputs.sequence.value,start:this.getStart(),end:this.getEnd(),name:this.getName()}}getStart(){return this.inputs.start.stringValue}getEnd(){return this.inputs.end.stringValue}getName(){const t=this.inputs.name.stringValue;return""==t?null:t}dialog(){const t=n.inputs(Object.values(this.inputs),{style:{minWidth:"320px"}});n.dialog({title:"Get Region"}).add(t).onOK((async()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Ke.handleErrorUI(t)}))})).show()}widget(){const t=n.inputs(Object.entries(this.inputs).filter((([t,e])=>!["table","sequence"].includes(t))).map((([t,e])=>e))),e=n.button("Get Region",(()=>{(async()=>{const t=this.getParams();await this.call.func.prepare(t).call(!0)})().catch((t=>{Ke.handleErrorUI(t)}))}));return o.Widget.fromRoot(n.divV([t,n.div(e)]))}}const Ke=new Ne,je="bypassLargeDataWarning";function Je(){return qt.NT.instance}let Qe=null;class ts{constructor(t){this._palette=t}get(t){return this._palette[t]}}async function es(){Ke.logger.debug("Bio: initBio(), started");const t=await i.functions.call("Chem:getRdKitModule");await Promise.all([(async()=>{await qt.NT.instance.loadLibraries()})(),(async()=>{const t=await Ke.getProperties(),e=new Ie(t);Ke.properties=e})()]).finally((()=>{Ke.completeInit()}));const e=qt.NT.instance.getBioLib(),s=[],n=[],o=e.getMonomerMolsByPolymerType("PEPTIDE");Object.keys(o).forEach((e=>{s.push(e);const i=o[e].replaceAll("#R","O "),r=t.get_mol(i),a=JSON.parse(r.get_descriptors()).CrippenClogP;n.push(a),r?.delete()}));const r=n.reduce(((t,e)=>t+e),0)/n.length||0,a={};for(let t=0;t<s.length;t++)a[s[t]]=n[t]<r?"#4682B4":"#DC143C";Qe=new ts(a),Ke.logger.debug("Bio: initBio(), completed")}function ss(t){const e=new Oe(t);return e.init().then((()=>{})).catch((t=>{const e=t instanceof Error?t.message:t.toString();i.shell.error(e)})),e}function is(){return qt.NT.instance.getBioLib()}function ns(t){const e="getRegionTopMenu",s=o.Func.find({package:Ke.name,name:e});if(1!==s.length)throw new Error(`Package '${Ke.name}' func '${e}' not found`);const i=s[0].prepare({table:t.dataFrame,sequence:t});return new Xe(i).widget()}async function os(t){return(0,qt.cf)()}function rs(t){try{new Xe(t).dialog()}catch(t){const e=t instanceof Error?t.message:t.toString(),s=t instanceof Error?t.stack:void 0;i.shell.error(`Get region editor error: ${e}`),Ke.logger.error(e,void 0,s)}}function as(t){const e=new ve;n.dialog({title:"Split to Monomers"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function ls(t){const e=new Jt(o.SEMTYPE.MACROMOLECULE);n.dialog({title:"Sequence Space"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call())).show()}function hs(t){const e=new Qt(o.SEMTYPE.MACROMOLECULE);n.dialog({title:"Activity Cliffs"}).add(e.paramsUI).onOK((async()=>t.func.prepare(e.funcParams).call(!0))).show()}function cs(t){const e=new Le(t);return e.init().then(),e}function us(){return new I}function ms(t){return function(t){const e=Array.from(t.dataFrame.columns).filter((t=>t.semType===o.SEMTYPE.MOLECULE)).map((t=>t.name));new Set(e).delete(t.name);const s=n.choiceInput("Monomer width",null!=t?.temp["monomer-width"]?t.temp["monomer-width"]:f.short,[f.short,f.long],(e=>{t.temp["monomer-width"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));s.setTooltip("In short mode, only the 'Max monomer length' characters are displayed, followed by .. if there are more");const i=parseInt(t.getTag(d.maxMonomerLength)),r=n.intInput("Max monomer length",isNaN(i)?Ke.properties.MaxMonomerLength:i,(e=>{t.setTag(d.maxMonomerLength,e.toString()),t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));r.setTooltip(`The max length of monomer name displayed without shortening in '${f.short}' monomer width mode.`);const a=n.intInput("Monomer margin",t.temp[".mm.cellRenderer.gapLength"]??0,(e=>{t.temp[".mm.cellRenderer.gapLength"]=e,t.setTag(".mm.cellRenderer.settingsChanged",v.true),t.dataFrame.fireValuesChanged()}));a.setTooltip("The size of margin between monomers (in pixels)");const l=n.boolInput("Color code",null==t?.temp["color-code"]||t.temp["color-code"],(e=>{t.temp["color-code"]=e,t.dataFrame.fireValuesChanged()}));l.setTooltip("Color code");const h=n.stringInput("Reference sequence",null!=t?.temp["reference-sequence"]?t?.temp["reference-sequence"]:"",(e=>{t.temp["reference-sequence"]=e,t.dataFrame.fireValuesChanged()}));h.setTooltip("Reference sequence is not empty, then the sequence will be render \nas a difference from the reference sequence");const c=n.boolInput("Compare with current",null==t?.temp["compare-with-current"]||t.temp["compare-with-current"],(e=>{t.temp["compare-with-current"]=e,t.dataFrame.fireValuesChanged()}));c.setTooltip('When on, all sequences get rendered in the "diff" mode');const u=n.inputs([s,r,a,h,l,c]);return new o.Widget(u)}(t)}function ds(t){return function(t){const e=n.div();e.classList.add("macromolecule-cell-comp-analysis-host");const s=t.cell.column.tags.alphabet;let i=w.UE.Color;switch(s){case"DNA":case"RNA":i=(0,b.py)("DNA");break;case"PT":i=(0,b.py)("PT")}const r=new Map;let l=0;const h=C.Cn.getOrCreate(t.cell.column).getSplitter()(t.value),c=h.length;a()(h).filter((t=>!!t&&""!==t)).forEach((t=>{const e=r.get(t)||0;r.set(t,e+1),l=Math.max(l,e+1)})),l/=c;const u={},m=Array.from(r.entries());m.sort(((t,e)=>e[1]-t[1])),m.forEach((([t,e])=>{const s=e/c,o=i.get(t),r=n.div("",{classes:"macromolecule-cell-comp-analysis-bar"});r.style.width=s/l*50+"px";const a=n.div((100*s).toFixed(2)+"%");r.style.backgroundColor=o,u[t]=n.div([r,a],{classes:"macromolecule-cell-comp-analysis-value"})}));const d=n.tableFromMap(u);return Array.from(d.rows).forEach((t=>{const e=t.getElementsByClassName("macromolecule-cell-comp-analysis-bar")[0].style.backgroundColor;t.cells[0].style.color=e})),e.appendChild(d),new o.Widget(e)}(t)}function gs(){return new I}function ps(){return new N}function fs(t,e,s,i,n){const o=new B.k(i,n,s,e);return"Local 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N={seqCol:T,methodName:m,similarityMetric:u,embedAxesNames:a,options:C},{distance:L,coordinates:_}=await p(N);for(const e of _)t.columns.add(e);let R=L;const O=Object.values($.U).map((t=>t.toString())).includes(u);O&&!L&&(R=mt.H.calc(e.toList(),$.o[u]()).data);const k=function(t,e,s){const i=[],n=[],o=[],r=[],a=new Set;for(let l=0;l!=t.length;++l)for(let h=0;h!=t.length-l;++h){const c=t[l]?t[l].get(h):0;if(c>=e){o.push(l),r.push(l+h+1),a.add(l),a.add(l+h+1),i.push(c);const t=Math.abs(s.get(l)-s.get(l+h+1));n.push(1!=c?t/(1-c):1/0)}}return{simVals:i,saliVals:n,n1:o,n2:r,cliffsMolIds:a}}(await async function(t,e,s,i){const n=t.categories,r=t.getRawData(),a=o.Column.string("seq",t.length).init((t=>n[r[t]])),l=o.DataFrame.fromColumns([a]),h=t.length;let c=Array(h-1);return s&&e?function(t,e,s){const i=(0,dt.y)(t);for(let n=0;n<t-1;++n){const r=new Float32Array(t-n-1).fill(0);for(let s=n+1;s<t;++s){const t=i(n,s);r[s-n-1]=e[t]===o.FLOAT_NULL?0:(0,j.Om)(e[t])}s[n]=o.Column.fromFloat32Array("similarity",r)}}(h,e,c):c=await i(h,t,l,"seq",c),c}(T,R,O,f),S,h),P=function(t,e,s,i,n,r){const a=new Array(t).fill(0);for(let t=0;t!=s.length;++t)e[t]!=1/0&&(r.get(s[t])>r.get(i[t])?a[s[t]]+=e[t]:a[i[t]]+=e[t]);return o.Column.fromList("double",`sali_${n[0].substring(n[0].lastIndexOf("_"))}`,a)}(T.length,k.saliVals,k.n1,k.n2,a,h);t.columns.add(P);const G=function(t,e){const s="containsCliff",i=t.columns.names().filter((t=>t.includes(s))).length+1,n=`${s}_${i}`;return o.Column.bool(n,t.rowCount).init((t=>e.has(t)))}(t,k.cliffsMolIds);t.columns.add(G);const F=function(t){const e=t.filter((t=>t!==1/0)),s=Math.min(...e);return{max:Math.max(...e),min:s}}(k.saliVals),H=.8/(F.max-F.min),V=i.shell.getTableView(t.name);V.grid.columns.byName(G.name).visible=!1;const W=V.addViewer(o.VIEWER.SCATTER_PLOT,{xColumnName:a[0],yColumnName:a[1],size:P.name,color:h.name,showXSelector:!1,showYSelector:!1,showSizeSelector:!1,showColorSelector:!1,markerMinSize:5,markerMaxSize:25,title:l}),D=W.getInfo().canvas,B=function(t,e,s,i,n){const r=new Array(t.n1.length).fill(null);for(let e=0;e<t.n1.length;e++){const s=t.n1[e],i=t.n2[e];r[e]={id:e,mols:[s,i],selected:!1,a:[],b:[]}}const a=o.DataFrame.create(r.length);return vt.forEach(((t,s)=>{a.columns.addNewString(t).init((t=>e.get(r[t].mols[s]))),function(t,e){Object.keys(e).forEach((s=>{t.tags[s]=e[s]}))}(a.col(t),n),a.col(t).semType=i})),a.columns.addNewFloat(yt).init((t=>Math.abs(s.get(r[t].mols[0])-s.get(r[t].mols[1])))),a.columns.addNewInt(Ct).init((t=>t)),a.columns.addNewFloat(bt).init((e=>t.saliVals[e])),a.columns.addNewFloat(wt).init((e=>t.simVals[e])),a.name=`${pt}${gt}`,{lines:r,linesDf:a}}(k,e,h,d,g),U=w?w(B.linesDf,vt).sort([bt],[!1]):B.linesDf.plot.grid().sort([bt],[!1]);t.temp[".cliffsDfGrid"]=U;const Z=n.button(`${B.linesDf.rowCount} cliffs`,(()=>{V.dockManager.dock(U,"down",null,"Activity cliffs",v??.2)}));Z.classList.add("scatter_plot_link","cliffs_grid"),W.root.append(Z);const Y=n.switchInput("Show only cliffs",!1,(()=>{Y.value?(W.dataFrame.setTag(St,G.name),t.rows.match({[G.name]:!0}).filter(),ft.next(G.name)):(W.dataFrame.setTag(St,""),t.filter.setAll(!0,!0),ft.next(""))}));Y.root.classList.add("scatter_plot_link","show_only_cliffs"),W.root.append(Y.root),ft.subscribe((t=>{Y.enabled=""===t||t===G.name}));const z=i.events.onViewerClosed.subscribe((t=>{t.args.viewer===W&&(V.dockManager.close(U.root),z.unsubscribe(),V.subs=V.subs.filter((t=>t!==z)))}));return V.subs.push(z),B.linesDf.onCurrentCellChanged.subscribe((()=>{M=!0;const s=B.linesDf.currentCol&&B.linesDf.currentCol.name===vt[1]?1:0,o=-1!==B.linesDf.currentRowIdx?B.lines[B.linesDf.currentRowIdx]:null;W.dataFrame.currentRowIdx=o?o.mols[s]:-1,W.dataFrame.filter.set(0,!B.lines[0].selected),W.dataFrame.filter.set(0,B.lines[0].selected),o&&setTimeout((()=>{!function(t,e,s,o,r,a,l,h){const c=e.getPane("Cliff Details");n.empty(c.root);const u=h({cashedData:s,line:o,df:t,seqCol:r,activityCol:a,sali:l});c.root.append(u),setTimeout((()=>{i.shell.o=e.root}),500)}(t,x,E,o,e,h,B.linesDf.get(bt,o.id),b);const s=W.dataFrame.getSortedOrder(V.grid.sortByColumns,V.grid.sortTypes);V.grid.scrollToCell(e.name,s.indexOf(W.dataFrame.currentRowIdx))}),1e3)})),B.linesDf.onSelectionChanged.subscribe((e=>{if(!1===B.linesDf.selection.anyTrue)B.lines.forEach((t=>{t.selected=!1}));else if(-1!==B.linesDf.mouseOverRowIdx){const t=B.lines[B.linesDf.mouseOverRowIdx];t.selected=!t.selected}setTimeout((()=>{const e=o.BitSet.create(t.rowCount);B.lines.forEach((t=>{t.selected&&t.mols.forEach((s=>{e.set(s,t.selected,!0)}))})),t.selection.copyFrom(e),V.grid.invalidate()}),300)})),t.onSelectionChanged.subscribe((e=>{A?A=!1:!1===t.selection.anyTrue&&"number"==typeof e&&(B.lines.forEach((t=>{t.selected=!1})),U.dataFrame.selection.setAll(!1,!1),U.invalidate())})),D.addEventListener("mousemove",(function(i){clearTimeout(I),I=s.g.setTimeout((function(){const s=Tt(i,D,B.lines);s&&-1===t.mouseOverRowIdx&&n.tooltip.show(y({cashedData:E,line:s,df:t,seqCol:e,activityCol:h}),i.clientX,i.clientY)}),500)})),D.addEventListener("mousedown",(function(e){A=!0;const s=Tt(e,D,B.lines);if(s&&-1===t.mouseOverRowIdx){e.ctrlKey?(s.selected=!s.selected,B.linesDf.selection.set(s.id,s.selected)):B.linesDf.currentRowIdx!==s.id&&(B.linesDf.currentRowIdx=s.id,t.currentRowIdx=s.mols[0],t.filter.set(0,!B.lines[0].selected),t.filter.set(0,B.lines[0].selected));const i=B.linesDf.getSortedOrder(U.sortByColumns,U.sortTypes);U.scrollToCell(vt[0],i.indexOf(s.id))}})),W.onEvent("d4-before-draw-scene").subscribe((e=>{const s=function(t,e,s,i,n,o,r){const a=i.lines,l=t.getInfo().canvas.getContext("2d"),h=t.dataFrame.columns.byName(e),c=t.dataFrame.columns.byName(s);for(let e=0;e<a.length;e++){const s=t.worldToScreen(h.get(a[e].mols[0]),c.get(a[e].mols[0])),u=t.worldToScreen(h.get(a[e].mols[1]),c.get(a[e].mols[1]));a[e].a=[s.x,s.y],a[e].b=[u.x,u.y];const m=new Path2D;m.moveTo(a[e].a[0],a[e].a[1]);const d=a[e].selected?"255,255,0":"0,128,0",g=n[e]===1/0?1:.2+(n[e]-r)*o;l.strokeStyle=`rgba(${d},${g})`,l.lineWidth=a[e].id===i.linesDf.currentRowIdx?3:1,m.lineTo(a[e].b[0],a[e].b[1]),l.stroke(m)}return a}(W,a[0],a[1],B,k.saliVals,H,F.min);if(M){const t=s[B.linesDf.currentRowIdx];setTimeout((()=>{const{zoomLeft:e,zoomRight:s,zoomTop:i,zoomBottom:n}=function(t,e,s,i,n,o){const r=Math.abs(s-n),a=Math.abs(i-o),l=t/r,h=e/a,c=Math.min(l,h),u=t/c*5,m=e/c*5,d=(s<n?s:n)+r/2-u/2,g=(i>o?i:o)-a/2+m/2;return{zoomLeft:d,zoomRight:d+u,zoomTop:g,zoomBottom:g-m}}(W.viewport.width,W.viewport.height,W.dataFrame.get(a[0],t.mols[0]),W.dataFrame.get(a[1],t.mols[0]),W.dataFrame.get(a[0],t.mols[1]),W.dataFrame.get(a[1],t.mols[1]));W.zoom(e,i,s,n)}),300),M=!1}Y.value?t.rows.match({[G.name]:!0}).filter():!0===Y.enabled&&t.filter.setAll(!0,!1)})),W.addProperty("similarityLimit","double",S),x=function(){const t=n.accordion(),e=n.element("i");return e.className="grok-icon svg-icon svg-view-layout",t.addTitle(n.span([e,n.label("Activity cliffs")])),t.addPane("Cliff Details",(()=>n.divText("Cliff has not been selected")),!0),i.shell.o=t.root,t}(),W}(t,g,null,c,"Activity cliffs",r,a,d,l,o.SEMTYPE.MACROMOLECULE,u,X,At,Et,xt,_t,h),f=l===$t.AL.UMAP?5e3:2e3;if(t.rowCount>2e4)i.shell.warning("Too many rows, maximum for sequence activity cliffs is 20000");else{if(!(t.rowCount>f)||h?.[je])return await p();n.dialog().add(n.divText("Activity cliffs analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{const t=o.TaskBarProgressIndicator.create("Running sequence activity cliffs ..."),e=await p();return t.close(),e})).show()}}async function Ss(t,e,s,r=$.U.LEVENSHTEIN,a,l,h){if(await(0,zt.gw)(10),!(0,be.n)(e,"Sequence space"))return;let c;const u=o.TaskBarProgressIndicator.create("Initializing sequence space ...");try{function m(e,s,n){let r=null,l=null;t.columns.names().includes(d[0])?(r=t.columns.byName(d[0]),l=t.columns.byName(d[1])):(r=t.columns.add(o.Column.float(d[0],t.rowCount)),l=t.columns.add(o.Column.float(d[1],t.rowCount)),a&&(c=i.shell.tableView(t.name).scatterPlot({x:d[0],y:d[1],title:"Sequence space"}))),r.init((t=>n[t]?n[t][0]:void 0)),l.init((t=>n[t]?n[t][1]:void 0));const h=e/s*100;u.update(h,`Running sequence space ... ${h.toFixed(0)}%`)}const d=K(t),g=o.DataFrame.fromColumns([e]).clone(),p=function(t,e){const s=e.categories.map(((t,e)=>t?null:e)).filter((t=>null!==t)),i=[...e.getRawData()],n=[];let o=0;for(let e=0;e<t.rowCount;e++)s.includes(i[e])&&(t.rows.removeAt(e-o),n.push(e),o+=1);return n}(g,e),f={seqCol:g.col(e.name),methodName:s,similarityMetric:r,embedAxesNames:d,options:{...h,sparseMatrixThreshold:l??.8,usingSparseMatrix:t.rowCount>2e4}},y=s===$t.AL.UMAP?1e5:15e3,b=s===$t.AL.UMAP?5e3:2e3;if(t.rowCount>y)return void i.shell.warning(`Too many rows, maximum for sequence space is ${y}`);async function w(){let t=null;const e=i.events.onViewerClosed.subscribe((s=>{const n=s.args.viewer;n?.getOptions()?.look?.title&&c?.getOptions()?.look?.title&&n?.getOptions()?.look?.title===c?.getOptions()?.look?.title&&(i.events.fireCustomEvent(Z,{}),e.unsubscribe(),t?.(),u.close())})),s=new Promise((async e=>{t=e,e(await X(f,h?.[je]?void 0:m))})),n=await s;return u.close(),e.unsubscribe(),n?C(n):n}if(!(t.rowCount>b)||h?.[je])return await w();function C(e){const s=e.coordinates;for(const e of s){const s=e.toList();p.forEach((t=>s.splice(t,0,null)));let i=t.columns.byName(e.name);i||(i=o.Column.float(e.name,s.length),t.columns.add(i)),i.init((t=>s[t]))}if(a)return c||(c=i.shell.tableView(t.name).scatterPlot({x:d[0],y:d[1],title:"Sequence space"})),c}n.dialog().add(n.divText("Sequence space analysis might take several minutes.\n Do you want to continue?")).onOK((async()=>{await w()})).onCancel((()=>{u.close()})).show()}catch(v){console.error(v),u.close()}}async function Ts(t,e){if(0===o.Func.find({package:"Chem",name:"getRdKitModule"}).length)return void i.shell.warning('Transformation to atomic level requires package "Chem" installed.');if(!(0,be.n)(e,"To Atomic Level"))return;const s=(await Je()).getBioLib(),r=await(0,Ot.i0)(t,e,s);null!==r.col&&(t.columns.add(r.col,!0),await i.data.detectSemanticTypes(t)),r.warnings&&r.warnings.length>0&&i.shell.warning(n.list(r.warnings))}function Ms(){(0,we.K)()}async function As(t=null,e=null){return(0,we.K)({col:t,clustersCol:e})}async function Es(){const t=i.shell.tv,e=t.dataFrame.columns.toList().filter((t=>t.semType==o.SEMTYPE.MACROMOLECULE&&(C.Cn.getOrCreate(t),!0))),s=async e=>{if(!(0,be.n)(e,"Composition"))return;const s=t.addViewer("WebLogo",{sequenceColumnName:e.name});i.shell.tv.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"Composition analysis",.25)};let r=null;if(0!=e.length){if(e.length>1){const t=e.map((t=>t.name)),i=e.find((t=>C.Cn.getOrCreate(t).isMsa())),o=n.choiceInput("Column",i?i.name:t[0],t);n.dialog({title:"Composition Analysis",helpUrl:"/help/domains/bio/macromolecules.md#composition-analysis"}).add(n.div([o])).onOK((async()=>{const t=e.find((t=>t.name==o.value))??null;t&&await s(t)})).show()}else r=e[0];r&&await s(r)}else i.shell.error("Current table does not contain sequences")}function xs(t){return new kt.i(t).importFasta()}function Is(t){return console.log(t),[]}function Ns(){const t=(0,Ft.B)()[0];(0,Rt.O)(t)}function Ls(){return new xe}async function _s(t){const e=o.TaskBarProgressIndicator.create("Test detectMacromolecule..."),s=(await i.dapi.files.list(t,!0,"")).filter((t=>t.fileName.endsWith(".csv")));let n=0;const r=[];for(const a of s)try{const e=await i.dapi.files.readAsText(t+a.fullPath),s=o.DataFrame.fromCsv(e);for(const t of s.columns)await i.functions.call("Bio:detectMacromolecule",{col:t})===o.SEMTYPE.MACROMOLECULE&&r.push({file:a.path,result:"detected",column:t.name,message:`units: ${t.getTag(o.TAGS.UNITS)}`})}catch(t){r.push({file:a.path,result:"error",column:null,message:t instanceof Error?t.message:t.toString()})}finally{n+=1,e.update(100*n/s.length,`Test ${a.fileName}`)}i.shell.info("Test Demo:Files for detectMacromolecule finished."),e.close();const a=o.DataFrame.fromObjects(r);return a.name=`datasets_detectMacromolecule_${t}`,a}async function Rs(t,e){await(0,Se.n)(t,e)}function Os(t){const e=C.Cn.getOrCreate(t).stats;return Object.keys(e.freq)}function ks(){return new Dt}function Ps(){const t=i.shell.v,e=t.addViewer("Sequence Similarity Search");t.dockManager.dock(e,"down")}function Gs(){return new Ut}function Fs(){const t=i.shell.v,e=t.addViewer("Sequence Diversity Search");t.dockManager.dock(e,"down")}function Hs(t){const e=(0,Ft.B)();1===e.length?t.func.prepare({macromolecules:e[0]}).call(!0):new z.uH(e)}function Vs(t){i.shell.tv.getFiltersGroup({createDefaultFilters:!1}).updateOrAdd({type:"Bio:bioSubstructureFilter",column:t.name,columnName:t.name}),i.shell.tv.grid.scrollToCell(t,0)}async function Ws(t,e,s){return se(t,e,s,te.IDENTITY)}async function Ds(t,e,s){return se(t,e,s,te.SIMILARITY)}function Bs(){(0,Zt.C2)()}function Us(){return new Yt.ST}async function Zs(){const t=o.TaskBarProgressIndicator.create("WebLogo");try{const t=new URLSearchParams(window.location.search),e=new Ce(t,"webLogoLargeApp"),s=await Ke.files.readCsv("data/sample_PT_100000x5.csv");await i.data.detectSemanticTypes(s),await e.init(s)}finally{t.close()}}async function Ys(){const t=o.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=new $e(t,"getRegionApp");await e.init()}finally{t.close()}}async function zs(){const t=o.TaskBarProgressIndicator.create("getRegion ...");try{const t=new URLSearchParams(window.location.search),e=await Ke.files.readCsv("data/sample_HELM_empty_vals.csv"),s=new $e(t,"getRegionHelmApp");await s.init({df:e,colName:"HELM"})}finally{t.close()}}function qs(t,e){!function(t,e){const s=C.Cn.getOrCreate(t.column),n=Object.values(b.r2).filter((t=>t!==s.units));e.group("Copy").items(n,(e=>{const s=C.Cn.getOrCreate(t.column),n=e===b.r2.SEPARATOR?Ke.properties.DefaultSeparator:void 0,o=s.getConverter(e,n)(t.value);navigator.clipboard?(navigator.clipboard.writeText(o),i.shell.info(`Value of notation '${e}' copied to clipboard`)):i.shell.warning("The clipboard functionality requires a secure origin — either HTTPS or localhost")}))}(t,e)}async function $s(){await async function(){let t,e;try{const s=new oe("Similarity, Diversity","Sequence similarity tracking and evaluation dataset diversity");await s.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ke.files.readCsv(ae),t=i.shell.addTableView(e),t.grid.columns.byName("cluster").visible=!1,t.grid.columns.byName("sequence_id").visible=!1,t.grid.columns.byName("sequence").width=300,t.grid.columns.byName("activity").visible=!1,t.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find the most similar sequences to the current one",(async()=>{const s=await e.plot.fromType("Sequence Similarity Search",{moleculeColumnName:"sequence",similarColumnLabel:"Similar to current"});t.dockManager.dock(s,o.DOCK_TYPE.RIGHT,null,"Similarity search",.35)}),{description:"Add 'Sequence Similarity Search' viewer.",delay:2e3}).step("Explore most diverse sequences in a dataset",(async()=>{const s=await e.plot.fromType("Sequence Diversity Search",{moleculeColumnName:"sequence",diverseColumnLabel:"Top diverse sequences of all data"});t.dockManager.dock(s,o.DOCK_TYPE.DOWN,null,"Diversity search",.27)}),{description:"Add 'Sequence Deversity Search' viewer.",delay:2e3}).step("Choose another sequence for similarity search",(async()=>{e.currentRowIdx=3}),{description:"Handling current row changed of data frame showing update of similar sequences.",delay:2e3}).step("One more sequence for similarity search",(async()=>{e.currentRowIdx=7}),{description:"Just one more sequence to search similar ones.",delay:2e3}).start()}catch(t){re(t)}}()}async function Xs(){await async function(){let t,e,s,n,r;try{const a=new oe("Sequence Space","Exploring sequence space of Macromolecules, comparison with hierarchical clustering results");await a.step("Load DNA sequences",(async()=>{[n,t,e]=await Promise.all([Ke.files.readCsv(ue),he(),ce()]),s=i.shell.addTableView(n),s.grid.props.rowHeight=22,s.grid.columns.byName("cluster").visible=!1,s.grid.columns.byName("sequence").width=200,s.grid.columns.byName("is_cliff").visible=!1,i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Build sequence space",(async()=>{r=await async function(t,e,s,i){let n;{const t=Object.values(ie);for(let s=0;s<t.length;s++){const i=t[s];if(!e.col(i)){const n=s==t.length-1;e.columns.add(o.Column.float(i,e.rowCount),n)}}if(e.rowCount>=1){const i=e.getCol(s).toList(),n=Date.now();Ke.logger.debug("Bio: demoBio01aUI(), calc reduceDimensionality start...");const o=await Y(i,"UMAP",Mt.W.Levenshtein,{}),r=Date.now();Ke.logger.debug(`Bio: demoBio01aUI(), calc reduceDimensionality ET: ${(r-n)/1e3} s`);for(let s=0;s<t.length;s++){const i=t[s],n=e.getCol(i),r=o.embedding[s];n.init((t=>r[t]))}const a=Date.now();Ke.logger.debug(`MLB: MlbVrSpaceBrowser.buildView(), postprocess reduceDimensionality ET: ${(a-r)/1e3} s`)}n=await e.plot.fromType(o.VIEWER.SCATTER_PLOT,{xColumnName:ie.X,yColumnName:ie.Y,lassoTool:!0})}return t.dockManager.dock(n,o.DOCK_TYPE.RIGHT,null,"Sequence Space",.35),n}(s,n,me)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Cluster sequences",(async()=>{const i=n.getCol(me).toList(),o=mt.H.calc(i,((t,e)=>le.T(t,e)/((t.length+e.length)/2))),r=await t.hierarchicalClusteringByDistance(o,"ward");e.injectTreeForGrid(s.grid,r,void 0,150,void 0)}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Select a sequence",(async()=>{n.selection.init((t=>[15].includes(t)))}),{description:"Handling selection of data frame row reflecting on linked viewers.",delay:2e3}).step("Select a bunch of sequences",(async()=>{const t=n.getCol("sequence_id");n.selection.init((e=>["c0_seq120","c0_seq105","c0_seq121","c0_seq93"].includes(t.get(e)))),n.currentRowIdx=27}),{description:"Selecting a group of rows from a data frame to show their similarity and proximity to each other on a viewer..",delay:2e3}).start()}catch(t){re(t)}}()}async function Ks(){await async function(){let t,e,s,n,r;const a=$t.AL.UMAP;try{const l=new oe("Activity Cliffs","Activity Cliffs analysis on Macromolecules data");await l.step("Load DNA sequences",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,[s,t,e]=await Promise.all([Ke.files.readCsv(pe),he(),ce()]),n=i.shell.addTableView(s),n.grid.props.rowHeight=22,n.grid.columns.byName("cluster").visible=!1,n.grid.columns.byName("sequence").width=300,n.grid.columns.byName("is_cliff").visible=!1}),{description:"Load dataset with macromolecules of 'fasta' notation, 'DNA' alphabet.",delay:2e3}).step("Find activity cliffs",(async()=>{r=await vs(s,s.getCol("Sequence"),s.getCol("Activity"),80,a),n.dockManager.dock(r,o.DOCK_TYPE.RIGHT,null,"Activity Cliffs",.35),ge()(r.root).find("button.scatter_plot_link,cliffs_grid").get()[0].click()}),{description:"Reveal similar sequences with a cliff of activity.",delay:2e3}).step("Cluster sequences",(async()=>{const i=o.TaskBarProgressIndicator.create("Running sequence clustering..."),r=s.getCol("sequence").toList(),a=mt.H.calc(r,((t,e)=>le.T(t,e)/((t.length+e.length)/2))),l=await t.hierarchicalClusteringByDistance(a,"ward");i.close(),e.injectTreeForGrid(n.grid,l,void 0,150,void 0),n.grid.columns.byName("Activity").scrollIntoView()}),{description:"Perform hierarchical clustering to reveal relationships between sequences.",delay:2e3}).step("Browse the cliff",(async()=>{const t=r.dataFrame.temp[".cliffsDfGrid"];t.dataFrame.rowCount>0&&(t.dataFrame.currentRowIdx=0)}),{description:"Zoom in to explore selected activity cliff details.",delay:2e3}).start()}catch(t){re(t)}}()}async function js(){await async function(){const t="HELM";let e,s,r;try{await new oe("Atomic Level","Atomic level structure of Macromolecules").step("Loading Macromolecules notation 'Helm'",(async()=>{i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1,e=await Ke.files.readCsv("samples/HELM.csv"),s=i.shell.addTableView(e);for(let e=0;e<s.grid.columns.length;e++){const i=s.grid.columns.byIndex(e);[t,"Activity"].includes(i.name)||(i.visible=!1)}}),{description:"Load dataset with macromolecules of 'fasta' notation, 'PT' alphabet (protein, aminoacids).",delay:2e3}).step("To atomic level",(async()=>{const s=e.getCol(t);await Ts(e,s)}),{description:"Get atomic level structures of Macromolecules.",delay:2e3}).step("Sketcher",(async()=>{const s=`molfile(${t})`;e.currentCell=e.cell(1,s);const i=e.currentCell.value,a=new o.chem.Sketcher(o.chem.SKETCHER_MODE.INPLACE);a.setMolFile(i),r=n.dialog().add(a).show(),await(0,zt.gw)(3e3),r.close()}),{description:"Display atomic level structure within a sketcher.",delay:2e3}).start()}catch(t){re(t)}}()}async function Js(){await async function(){let t,e,s,n,r,a;const l="msa(HELM)",h=$t.AL.UMAP;try{const c=new oe("Helm, MSA, Sequence Space","MSA and composition analysis on Helm data");await c.step("Load peptides with non-natural aminoacids in 'HELM' notation",(async()=>{t=i.shell.addTableView(e=await Ke.files.readCsv(ye)),i.shell.windows.showContextPanel=!1,i.shell.windows.showProperties=!1}),{description:"Load dataset with macromolecules of 'Helm' notation.",delay:2e3}).step("Align peptides with non-natural aminoacids with PepSeA",(async()=>{s=e.getCol("HELM");const t=fe.J[0];n=await(0,fe.f)(s,l,t,1.53,0,void 0),e.columns.add(n),await i.data.detectSemanticTypes(e)}),{description:"Multiple sequence alignment (MSA) performed with PepSeA tool operating on non-natural aminoacids as well.",delay:2e3}).step("Build sequence space",(async()=>{a=await Ss(e,n,h,$.U.LEVENSHTEIN,!0),t.dockManager.dock(a,o.DOCK_TYPE.RIGHT,null,"Sequence Space",.35)}),{description:"Reduce sequence space dimensionality to display on 2D representation.",delay:2e3}).step("Analyse sequence composition",(async()=>{r=await e.plot.fromType("WebLogo",{sequenceColumnName:l,positionWidth:40,maxHeight:50}),t.dockManager.dock(r,o.DOCK_TYPE.DOWN,null,"Composition analysis",.2)}),{description:"Composition analysis allows to reveal functional features of sequences like motifs, or variable loops.",delay:2e3}).start()}catch(t){re(t)}}()}async function Qs(t,e){var s;Fe(s=e),s.setTag("units",b.r2.SEPARATOR),s.setTag("separator","-"),await i.data.detectSemanticTypes(t)}function ti(t){return function(t){function e(t){return t===c[0]?[Ge].concat(m.getMonomerSymbolsByType("PEPTIDE")):t===c[1]?[Ge].concat(m.getMonomerSymbolsByRGroup(3,"PEPTIDE")):["C"]}function s(){"N-Cys"===u.value?(d=e("N-O"),g=e("N-Cys")):(d=e(u.value),g=[...d]),p=n.choiceInput("R1:",d[0],d,(()=>{r.next()})),f=n.choiceInput("R2:",g[0],g,(()=>{r.next()})),r.next(),n.empty(y),[p,f].forEach((t=>{y.appendChild(t.root)}))}const i=new O.Subject,r=new O.Subject;i.subscribe((()=>{a.cyclizationType=u.value,s()})),r.subscribe((()=>{a.rightTerminal=f.value,a.leftTerminal=p.value}));const a={},l=["Cyclization"],h=n.choiceInput("Modification",l[0],l,(()=>a.transformationType=h.value)),c=["N-O","R3-R3","N-Cys"],u=n.choiceInput("Type",c[0],c,(()=>{i.next()})),m=qt.NT.instance.getBioLib();let d=[],g=[],p=n.choiceInput("R1:",d[0],d,(()=>{a.leftTerminal=p.value})),f=n.choiceInput("R2:",g[0],g,(()=>{a.rightTerminal=f.value}));const y=n.divV([p.root,f.root]);s(),a.cyclizationType=u.value,a.leftTerminal=p.value,a.rightTerminal=f.value,a.transformationType=h.value;const b=n.bigButton("Run",(async()=>Ye(t,a))),w=n.div([h,u,y,b]);return new o.Widget(w)}(t)}async function ei(t){const e=(0,q.Xk)(t),s=JSON.stringify(e);o.Utils.download(`${t.name}.json`,s)}},9017:(t,e,s)=>{"use strict";s.d(e,{k:()=>o});class i{constructor(){this.value=0,this.parentI=0,this.parentJ=0}}class n{constructor(t,e,s){this.seq1=t,this.seq2=e,this.score=s}}class o{fillNeedleman(){for(let t=0;t<=this.len1;t++)this.dpGrid[t][0].value=-t*this.gap,this.dpGrid[t][0].parentI=t-1,this.dpGrid[t][0].parentJ=0;for(let t=1;t<=this.len2;t++)this.dpGrid[0][t].value=-t*this.gap,this.dpGrid[0][t].parentI=0,this.dpGrid[0][t].parentJ=t-1}fillOne(t,e){this.dpGrid[t][e].value=Math.max(this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1],Math.max(this.dpGrid[t-1][e].value-this.gap,this.dpGrid[t][e-1].value-this.gap)),this.dpGrid[t][e].value==this.dpGrid[t-1][e-1].value+this.scores[t-1][e-1]?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e-1):this.dpGrid[t][e].value==this.dpGrid[t-1][e].value-this.gap?(this.dpGrid[t][e].parentI=t-1,this.dpGrid[t][e].parentJ=e):(this.dpGrid[t][e].parentI=t,this.dpGrid[t][e].parentJ=e-1)}gridFromName(t){switch(t){case"BLOSUM45":this.alignGrid=this.BLOSUM45,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM50":this.alignGrid=this.BLOSUM50,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM62":this.alignGrid=this.BLOSUM62,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM80":this.alignGrid=this.BLOSUM80,this.connections=this.CONBLO,this.step=1;break;case"BLOSUM90":this.alignGrid=this.BLOSUM90,this.connections=this.CONBLO,this.step=1;break;case"PAM30":this.alignGrid=this.PAM30,this.connections=this.CONBLO,this.step=1;break;case"PAM70":this.alignGrid=this.PAM70,this.connections=this.CONBLO,this.step=1;break;case"PAM250":this.alignGrid=this.PAM250,this.connections=this.CONBLO,this.step=1;break;case"NUCLEOTIDES":this.alignGrid=this.NUCLEOTIDES,this.connections=this.CONNUCL,this.step=1;break;case"TRANS":this.alignGrid=this.TRANS,this.connections=this.CONNUCL,this.step=1;break;case"SCHNEIDER":this.alignGrid=this.SCHNEIDER,this.connections=this.CONSCHN,this.step=3}this.fillScores()}constructResult(t,e){let s="",i="",o="";const r=this.dpGrid[t][e].value;for(let t=0;t<this.step;t++)o+="|";for(;t>0||e>0;){this.dpGrid[t][e].parentI==t?(s=o+s,i=this.seq2.substr((e-1)*this.step,this.step)+i):this.dpGrid[t][e].parentJ==e?(i=o+i,s=this.seq1.substr((t-1)*this.step,this.step)+s):(s=t-1>=0?this.seq1.substr((t-1)*this.step,this.step)+s:o+s,i=e-1>=0?this.seq2.substr((e-1)*this.step,this.step)+i:o+i);const n=t;t=this.dpGrid[t][e].parentI,e=this.dpGrid[n][e].parentJ}return new n(s,i,r)}fillScores(){this.scores=[];for(let t=0;t<this.len1;t++){this.scores.push([]);for(let e=0;e<this.len2;e++)this.scores[t].push(this.alignGrid[this.connections[this.seq1.substr(t*this.step,this.step)]][this.connections[this.seq2.substr(e*this.step,this.step)]])}}typeRec(){if(/[ATGC]*/.test(this.seq1)&&/[ATGC]*/.test(this.seq2))return"NUCLEOTIDES";if(/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq1)&&/[ARNDCQEGHILKMFPSTWYVBZX*]*/.test(this.seq2))return"BLOSUM62";throw Error("Can't recognize sequence type")}needlemanWunch(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}this.fillNeedleman();for(let t=1;t<=this.len1;t++)for(let e=1;e<=this.len2;e++)this.fillOne(t,e);return this.constructResult(this.len1,this.len2)}smithWaterman(){this.dpGrid=[];for(let t=0;t<this.len1+1;t++){const t=[];for(let e=0;e<this.len2+1;e++)t.push(new i);this.dpGrid.push(t)}let t=0,e=0,s=0;for(let i=1;i<=this.len1;i++)for(let n=1;n<=this.len2;n++)this.fillOne(i,n),this.dpGrid[i][n].value<=0?(this.dpGrid[i][n].value=0,this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0):0==this.dpGrid[this.dpGrid[i][n].parentI][this.dpGrid[i][n].parentJ].value&&(this.dpGrid[i][n].parentI=0,this.dpGrid[i][n].parentJ=0),this.dpGrid[i][n].value>t&&(t=this.dpGrid[i][n].value,e=i,s=n);return this.constructResult(e,s)}setSequences(t,e){this.seq1=t,this.seq2=e,this.len1=this.seq1.length/this.step,this.len2=this.seq2.length/this.step,this.fillScores()}setGap(t){this.gap=t}setMethod(t=""){"AUTO"==t&&(t=this.typeRec()),this.gridFromName(t)}constructor(t,e,s,i=""){this.seq1="",this.seq2="",this.gap=1,this.len1=0,this.len2=0,this.step=1,this.alignGrid=[],this.scores=[],this.dpGrid=[],this.connections={},this.BLOSUM45=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-2,-2,0,-1,-1,0,-5],[-2,7,0,-1,-3,1,0,-2,0,-3,-2,3,-1,-2,-2,-1,-1,-2,-1,-2,-1,0,-1,-5],[-1,0,6,2,-2,0,0,0,1,-2,-3,0,-2,-2,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-1,2,7,-3,0,2,-1,0,-4,-3,0,-3,-4,-1,0,-1,-4,-2,-3,5,1,-1,-5],[-1,-3,-2,-3,12,-3,-3,-3,-3,-3,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-2,-3,-2,-5],[-1,1,0,0,-3,6,2,-2,1,-2,-2,1,0,-4,-1,0,-1,-2,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-2,0,-3,-2,1,-2,-3,0,0,-1,-3,-2,-3,1,4,-1,-5],[0,-2,0,-1,-3,-2,-2,7,-2,-4,-3,-2,-2,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-5],[-2,0,1,0,-3,1,0,-2,10,-3,-2,-1,0,-2,-2,-1,-2,-3,2,-3,0,0,-1,-5],[-1,-3,-2,-4,-3,-2,-3,-4,-3,5,2,-3,2,0,-2,-2,-1,-2,0,3,-3,-3,-1,-5],[-1,-2,-3,-3,-2,-2,-2,-3,-2,2,5,-3,2,1,-3,-3,-1,-2,0,1,-3,-2,-1,-5],[-1,3,0,0,-3,1,1,-2,-1,-3,-3,5,-1,-3,-1,-1,-1,-2,-1,-2,0,1,-1,-5],[-1,-1,-2,-3,-2,0,-2,-2,0,2,2,-1,6,0,-2,-2,-1,-2,0,1,-2,-1,-1,-5],[-2,-2,-2,-4,-2,-4,-3,-3,-2,0,1,-3,0,8,-3,-2,-1,1,3,0,-3,-3,-1,-5],[-1,-2,-2,-1,-4,-1,0,-2,-2,-2,-3,-1,-2,-3,9,-1,-1,-3,-3,-3,-2,-1,-1,-5],[1,-1,1,0,-1,0,0,0,-1,-2,-3,-1,-2,-2,-1,4,2,-4,-2,-1,0,0,0,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-1,-1,2,5,-3,-1,0,0,-1,0,-5],[-2,-2,-4,-4,-5,-2,-3,-2,-3,-2,-2,-2,-2,1,-3,-4,-3,15,3,-3,-4,-2,-2,-5],[-2,-1,-2,-2,-3,-1,-2,-3,2,0,0,-1,0,3,-3,-2,-1,3,8,-1,-2,-2,-1,-5],[0,-2,-3,-3,-1,-3,-3,-3,-3,3,1,-2,1,0,-3,-1,0,-3,-1,5,-3,-3,-1,-5],[-1,-1,4,5,-2,0,1,-1,0,-3,-3,0,-2,-3,-2,0,0,-4,-2,-3,4,2,-1,-5],[-1,0,0,1,-3,4,4,-2,0,-3,-2,1,-1,-3,-1,0,-1,-2,-2,-3,2,4,-1,-5],[0,-1,-1,-1,-2,-1,-1,-1,-1,-1,-1,-1,-1,-1,-1,0,0,-2,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM50=[[5,-2,-1,-2,-1,-1,-1,0,-2,-1,-2,-1,-1,-3,-1,1,0,-3,-2,0,-2,-1,-1,-5],[-2,7,-1,-2,-4,1,0,-3,0,-4,-3,3,-2,-3,-3,-1,-1,-3,-1,-3,-1,0,-1,-5],[-1,-1,7,2,-2,0,0,0,1,-3,-4,0,-2,-4,-2,1,0,-4,-2,-3,4,0,-1,-5],[-2,-2,2,8,-4,0,2,-1,-1,-4,-4,-1,-4,-5,-1,0,-1,-5,-3,-4,5,1,-1,-5],[-1,-4,-2,-4,13,-3,-3,-3,-3,-2,-2,-3,-2,-2,-4,-1,-1,-5,-3,-1,-3,-3,-2,-5],[-1,1,0,0,-3,7,2,-2,1,-3,-2,2,0,-4,-1,0,-1,-1,-1,-3,0,4,-1,-5],[-1,0,0,2,-3,2,6,-3,0,-4,-3,1,-2,-3,-1,-1,-1,-3,-2,-3,1,5,-1,-5],[0,-3,0,-1,-3,-2,-3,8,-2,-4,-4,-2,-3,-4,-2,0,-2,-3,-3,-4,-1,-2,-2,-5],[-2,0,1,-1,-3,1,0,-2,10,-4,-3,0,-1,-1,-2,-1,-2,-3,2,-4,0,0,-1,-5],[-1,-4,-3,-4,-2,-3,-4,-4,-4,5,2,-3,2,0,-3,-3,-1,-3,-1,4,-4,-3,-1,-5],[-2,-3,-4,-4,-2,-2,-3,-4,-3,2,5,-3,3,1,-4,-3,-1,-2,-1,1,-4,-3,-1,-5],[-1,3,0,-1,-3,2,1,-2,0,-3,-3,6,-2,-4,-1,0,-1,-3,-2,-3,0,1,-1,-5],[-1,-2,-2,-4,-2,0,-2,-3,-1,2,3,-2,7,0,-3,-2,-1,-1,0,1,-3,-1,-1,-5],[-3,-3,-4,-5,-2,-4,-3,-4,-1,0,1,-4,0,8,-4,-3,-2,1,4,-1,-4,-4,-2,-5],[-1,-3,-2,-1,-4,-1,-1,-2,-2,-3,-4,-1,-3,-4,10,-1,-1,-4,-3,-3,-2,-1,-2,-5],[1,-1,1,0,-1,0,-1,0,-1,-3,-3,0,-2,-3,-1,5,2,-4,-2,-2,0,0,-1,-5],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,2,5,-3,-2,0,0,-1,0,-5],[-3,-3,-4,-5,-5,-1,-3,-3,-3,-3,-2,-3,-1,1,-4,-4,-3,15,2,-3,-5,-2,-3,-5],[-2,-1,-2,-3,-3,-1,-2,-3,2,-1,-1,-2,0,4,-3,-2,-2,2,8,-1,-3,-2,-1,-5],[0,-3,-3,-4,-1,-3,-3,-4,-4,4,1,-3,1,-1,-3,-2,0,-3,-1,5,-4,-3,-1,-5],[-2,-1,4,5,-3,0,1,-1,0,-4,-4,0,-3,-4,-2,0,0,-5,-3,-4,5,2,-1,-5],[-1,0,0,1,-3,4,5,-2,0,-3,-3,1,-1,-4,-1,0,-1,-2,-2,-3,2,5,-1,-5],[-1,-1,-1,-1,-2,-1,-1,-2,-1,-1,-1,-1,-1,-2,-2,-1,0,-3,-1,-1,-1,-1,-1,-5],[-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,-5,1]],this.BLOSUM62=[[4,-1,-2,-2,0,-1,-1,0,-2,-1,-1,-1,-1,-2,-1,1,0,-3,-2,0,-2,-1,0,-4],[-1,5,0,-2,-3,1,0,-2,0,-3,-2,2,-1,-3,-2,-1,-1,-3,-2,-3,-1,0,-1,-4],[-2,0,6,1,-3,0,0,0,1,-3,-3,0,-2,-3,-2,1,0,-4,-2,-3,3,0,-1,-4],[-2,-2,1,6,-3,0,2,-1,-1,-3,-4,-1,-3,-3,-1,0,-1,-4,-3,-3,4,1,-1,-4],[0,-3,-3,-3,9,-3,-4,-3,-3,-1,-1,-3,-1,-2,-3,-1,-1,-2,-2,-1,-3,-3,-2,-4],[-1,1,0,0,-3,5,2,-2,0,-3,-2,1,0,-3,-1,0,-1,-2,-1,-2,0,3,-1,-4],[-1,0,0,2,-4,2,5,-2,0,-3,-3,1,-2,-3,-1,0,-1,-3,-2,-2,1,4,-1,-4],[0,-2,0,-1,-3,-2,-2,6,-2,-4,-4,-2,-3,-3,-2,0,-2,-2,-3,-3,-1,-2,-1,-4],[-2,0,1,-1,-3,0,0,-2,8,-3,-3,-1,-2,-1,-2,-1,-2,-2,2,-3,0,0,-1,-4],[-1,-3,-3,-3,-1,-3,-3,-4,-3,4,2,-3,1,0,-3,-2,-1,-3,-1,3,-3,-3,-1,-4],[-1,-2,-3,-4,-1,-2,-3,-4,-3,2,4,-2,2,0,-3,-2,-1,-2,-1,1,-4,-3,-1,-4],[-1,2,0,-1,-3,1,1,-2,-1,-3,-2,5,-1,-3,-1,0,-1,-3,-2,-2,0,1,-1,-4],[-1,-1,-2,-3,-1,0,-2,-3,-2,1,2,-1,5,0,-2,-1,-1,-1,-1,1,-3,-1,-1,-4],[-2,-3,-3,-3,-2,-3,-3,-3,-1,0,0,-3,0,6,-4,-2,-2,1,3,-1,-3,-3,-1,-4],[-1,-2,-2,-1,-3,-1,-1,-2,-2,-3,-3,-1,-2,-4,7,-1,-1,-4,-3,-2,-2,-1,-2,-4],[1,-1,1,0,-1,0,0,0,-1,-2,-2,0,-1,-2,-1,4,1,-3,-2,-2,0,0,0,-4],[0,-1,0,-1,-1,-1,-1,-2,-2,-1,-1,-1,-1,-2,-1,1,5,-2,-2,0,-1,-1,0,-4],[-3,-3,-4,-4,-2,-2,-3,-2,-2,-3,-2,-3,-1,1,-4,-3,-2,11,2,-3,-4,-3,-2,-4],[-2,-2,-2,-3,-2,-1,-2,-3,2,-1,-1,-2,-1,3,-3,-2,-2,2,7,-1,-3,-2,-1,-4],[0,-3,-3,-3,-1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n=await(0,r.D)(s,!0,e.temp["monomers-dict"]);return(await i.functions.call("Chem:searchSubstructure",{molStringsColumn:e.temp["monomeric-mols"],molString:n.get(0),molBlockFailover:""})).get(0)}async function g(t,e){const s=o.TaskBarProgressIndicator.create(`Invalidating molfiles for ${t.name}`);await(0,l.gw)(10);const i=new Map,n=await(0,r.D)(t,e,i);t.temp["monomeric-mols"]=n,t.temp["monomers-dict"]=i,t.temp["last-invalidated-version"]=t.version,s.close()}},2568:(t,e,s)=>{"use strict";s.d(e,{n:()=>r});var i=s(4469),n=s(976),o=s(499);function r(t,e,s=[],r=[],a=!0){const[l,h]=function(t,e,s=[],r=[]){let a=!0,l="";const h=o.Cn.getOrCreate(t);if(t.semType!==n.SEMTYPE.MACROMOLECULE)i.shell.warning(e+" analysis is allowed for Macromolecules semantic type"),a=!1;else{const t=h.notation;if(s.length>0&&!s.some((e=>t.toUpperCase()==e.toUpperCase())))l=`${e} + ' analysis is allowed for Macromolecules with notation ${0==s.length?"any notation":`notation${s.length>1?"s":""} ${s.map((t=>`"${t}"`)).join(", ")} `}.`,a=!1;else if(!h.isHelm()){const t=h.alphabet;r.length>0&&!r.some((e=>t.toUpperCase()==e.toUpperCase()))&&(l=`${e} + ' analysis is allowed for Macromolecules with alphabet ${0==r.length?"any alphabet":`alphabet${r.length>1?"s":""} ${r.map((t=>`"${t}"`)).join(", ")}.`}.`,a=!1)}}return[a,l]}(t,e,s,r);return a&&!l&&i.shell.warning(h),l}},3553:(t,e,s)=>{"use strict";s.d(e,{Of:()=>o,WY:()=>h,jB:()=>c,rs:()=>a});var i,n,o,r,a,l=s(8341);!function(t){t.SPLIT_COL="~split",t.ACTIVITY="~activity",t.ACTIVITY_SCALED="activity_scaled",t.ALIGNED_SEQUENCE="~aligned_sequence",t.AMINO_ACID_RESIDUE="AAR",t.POSITION="Pos",t.P_VALUE="pValue",t.MEAN_DIFFERENCE="Mean difference"}(i||(i={})),function(t){t.AAR="AAR",t.POSITION="Pos",t.SELECTION="selection"}(n||(n={})),function(t){t.MONOMER="Monomer",t.MACROMOLECULE_DIFFERENCE="MacromoleculeDifference",t.ACTIVITY="activity",t.ACTIVITY_SCALED="activityScaled"}(o||(o={})),function(t){t.CELL_CHANGING="isCellChanging"}(r||(r={})),function(t){t.SEPARATOR="."}(a||(a={}));const h="3.3.1",c={pepsea:{gapOpen:1.53,gapExtend:0,method:l.J[0]},kalign:{gapOpen:-1,gapExtend:-1,terminalGap:-1}}},4004:(t,e,s)=>{"use strict";s.d(e,{O:()=>m});var i=s(976),n=s(3870),o=s(4469),r=s(3336),a=s.n(r),l=s(8447),h=s(499);let c=null,u=[];function m(t){let e=t??o.shell.t.columns.bySemType("Macromolecule");if(!e)throw new Error("No column with Macromolecule semantic type found");let s=h.Cn.getOrCreate(e),r=s.notation;const m=n.divText("Current notation: "+r,{style:{"text-align":"center","font-weight":"bold","font-size":"14px",padding:"5px"}}),d=[l.r2.FASTA,l.r2.SEPARATOR,l.r2.HELM],g=n.columnInput("Column",o.shell.t,e,(t=>{t.semType===i.SEMTYPE.MACROMOLECULE?(e=t,s=h.Cn.getOrCreate(e),r=s.notation,r===l.r2.HELM&&(y.value="/"),m.textContent="Current notation: "+r,f=d.filter((t=>t!==r)),w=n.choiceInput("Convert to",f[0],f,b),b(),c?.clear(),c?.add(n.div([m,g.root,w.root,y.root]))):g.value=e})),p=["-",".","/"];let f=d.filter((t=>t!==r));const y=n.choiceInput("Separator",p[0],p),b=()=>{w.value!==l.r2.SEPARATOR?a()(y.root).hide():a()(y.root).show()};let w=n.choiceInput("Convert to",f[0],f,b);b(),w.onChanged((()=>{b()})),null==c&&(c=n.dialog("Convert Sequence Notation").add(n.div([m,g.root,w.root,y.root])).onOK((async()=>{const t=w.value,s=y.value??void 0;await async function(t,e,s){const i=h.Cn.getOrCreate(t).convert(e,s);t.dataFrame.columns.add(i);const n=await o.functions.call("Bio:detectMacromolecule",{col:i});return n&&(i.semType=n),await o.data.detectSemanticTypes(t.dataFrame),i}(e,t,s)})).show({x:350,y:100}),u.push(c.onClose.subscribe((t=>{u.forEach((t=>{t.unsubscribe()})),u=[],c=null}))))}},7958:(t,e,s)=>{"use strict";function i(t){return"string"==typeof t||t instanceof String?t:"StateError"===t.constructor.name?t.message:"StateError"===t.constructor.name&&"$thrownJsError"in t?i(t.$thrownJsError):t instanceof Error?t.message:t.toString()}function n(t){return t instanceof Error?t.stack:"StateError"===t.constructor.name&&"$thrownJsError"in t?n(t.$thrownJsError):void 0}function o(t){return[i(t),n(t)]}s.d(e,{yf:()=>o})},5490:(t,e,s)=>{"use strict";s.d(e,{NT:()=>M,cf:()=>S});var i,n=s(4469),o=s(3870),r=s(976),a=s(701);class l{constructor(t){this.init(t)}init(t){this.fileContent=t.replace(/\r/g,""),this._atomCount=void 0,this._atomTypes=void 0,this._bondCount=void 0,this._bondTypes=void 0,this.xyzAtomCoordinates=void 0,this._pairsOfBondedAtoms=void 0}get atomCount(){return void 0===this._atomCount&&this.setAtomAndBondCounts(),this._atomCount}get bondCount(){return void 0===this._bondCount&&this.setAtomAndBondCounts(),this._bondCount}get x(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.x}get y(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.y}get z(){var t;return null!==(t=this.xyzAtomCoordinates)&&void 0!==t||(this.xyzAtomCoordinates=this.parseAtomCoordinates()),this.xyzAtomCoordinates.z}get atomTypes(){var t;return null!==(t=this._atomTypes)&&void 0!==t||(this._atomTypes=this.parseAtomTypes()),this._atomTypes}get pairsOfBondedAtoms(){var t;return null!==(t=this._pairsOfBondedAtoms)&&void 0!==t||(this._pairsOfBondedAtoms=this.parseBondedAtomPairs()),this._pairsOfBondedAtoms}get bondTypes(){var t;return null!==(t=this._bondTypes)&&void 0!==t||(this._bondTypes=this.parseBondTypes()),this._bondTypes}setAtomAndBondCounts(){const{atomCount:t,bondCount:e}=this.parseAtomAndBondCounts();this._atomCount=t,this._bondCount=e}getNextColumnIdx(t){for(;!this.isWhitespace(t);)++t;for(;this.isWhitespace(t);)++t;return t}shiftIdxToSpecifiedColumn(t,e){let s=t;const i=this.isWhitespace(s)?e:e-1;for(let t=0;t<i;t++)s=this.getNextColumnIdx(s);return s}parseAtomTypes(){const t=this.atomCount,e=new Array(t);let s=this.getAtomBlockIdx();for(let i=0;i<t;i++)s=this.shiftIdxToAtomType(s),e[i]=this.parseAtomType(s),s=this.getNextLineIdx(s);return e}parseAtomCoordinates(){const t=new Float32Array(this.atomCount),e=new Float32Array(this.atomCount),s=new Float32Array(this.atomCount);let i=this.getAtomBlockIdx();for(let n=0;n<this.atomCount;n++){i=this.shiftIdxToXColumn(i);for(const o of[t,e,s])o[n]=this.parseFloatValue(i),i=this.getNextColumnIdx(i);i=this.getNextLineIdx(i)}return{x:t,y:e,z:s}}parseBondedAtomPairs(){const t=new Array(this.bondCount);let e=this.getBondBlockIdx();for(let s=0;s<this.bondCount;s++){e=this.shiftIdxToBondedAtomsPair(e);const i=new Uint16Array(2);i[0]=this.parseIntValue(e),e=this.getNextColumnIdx(e),i[1]=this.parseIntValue(e),t[s]=i,e=this.getNextLineIdx(e)}return t}parseBondTypes(){const t=this.bondCount,e=new Uint16Array(t);let s=this.getBondBlockIdx();for(let i=0;i<t;i++)s=this.shiftIdxToBondType(s),e[i]=this.parseIntValue(s),s=this.getNextLineIdx(s);return e}isWhitespace(t){const e=this.fileContent[t];return" "===e||"\t"===e}getNextLineIdx(t){return"\n"!==this.fileContent[t]?this.fileContent.indexOf("\n",t)+1:t+1}parseFloatValue(t){return this.parseNumericValue(parseFloat,t)}parseIntValue(t){return this.parseNumericValue(parseInt,t)}parseNumericValue(t,e){let s=e+1;for(;!this.isWhitespace(s);)++s;return t(this.fileContent.substring(e,s))}}class h extends l{constructor(t){super(t),this.init(t)}init(t){super.init(t)}parseAtomType(t){let e=t,s=e;return this.isQuote(e)?(s=this.getNextIdenticalChar(e),e++):s=this.fileContent.indexOf(" ",s),this.fileContent.substring(e,s)}isQuote(t){const e=this.fileContent[t].charCodeAt(0);return 39===e||34===e}getNextIdenticalChar(t){const e=this.fileContent[t];return e?this.fileContent.indexOf(e,t+1):-1}isQuery(){return this.isQueryOrFragment(((t,e)=>{return 39===t||34===t||76===t&&!((s=this.fileContent.charCodeAt(e+1))>64&&s<91||s>96&&s<123);var s}))}isFragment(){return this.isQueryOrFragment((t=>82===t||42===t))}isQueryOrFragment(t){const e=this.atomCount;let s=this.getAtomBlockIdx();for(let i=0;i<e;i++){if(s=this.shiftIdxToAtomType(s),t(this.fileContent.charCodeAt(s),s))return!0;s=this.getNextLineIdx(s)}return!1}}!function(t){t.HEADER="V2000",t[t.NUM_OF_HEADER_LINES=3]="NUM_OF_HEADER_LINES",t[t.NUM_OF_COUNTS_DIGITS=3]="NUM_OF_COUNTS_DIGITS",t[t.ATOM_TYPE_COL=4]="ATOM_TYPE_COL",t[t.FIRST_BONDED_ATOM_COL=1]="FIRST_BONDED_ATOM_COL",t[t.BOND_TYPE_COL=3]="BOND_TYPE_COL",t[t.RGP_SHIFT=8]="RGP_SHIFT",t.RGP_LINE="M RGP",t.A_LINE="A ",t.END="M END"}(i||(i={}));class c extends h{constructor(t){super(t)}static validate(t){return-1!==t.indexOf(i.HEADER)&&-1!==t.indexOf(i.END)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,i.ATOM_TYPE_COL)}getCountsLineIdx(){let t=0;for(let e=0;e<i.NUM_OF_HEADER_LINES;++e)t=this.getNextLineIdx(t);return t}getAtomBlockIdx(){let t=this.getCountsLineIdx();return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){return this.getNextColumnIdx(t)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,i.FIRST_BONDED_ATOM_COL)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,i.BOND_TYPE_COL)}getBondBlockIdx(){let t=this.getAtomBlockIdx();for(let e=0;e<this.atomCount;e++)t=this.getNextLineIdx(t);return t}parseAtomAndBondCounts(){let t=this.getCountsLineIdx(),e=t+i.NUM_OF_COUNTS_DIGITS;const s=parseInt(this.fileContent.substring(t,e));return t=e,e+=i.NUM_OF_COUNTS_DIGITS,{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class u extends h{constructor(t){super(t),this.init(t)}shiftIdxToAtomType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getCountsLineIdx(){return this.fileContent.indexOf("M V30 COUNTS ")}getAtomBlockIdx(){let t=this.fileContent.indexOf("M V30 BEGIN ATOM");return t=this.getNextLineIdx(t),t}shiftIdxToXColumn(t){let e=this.shiftIdxToAtomType(t);return this.isQuote(e)?(e=this.getNextIdenticalChar(e),e=this.getNextColumnIdx(e),e):this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondedAtomsPair(t){return this.shiftIdxToSpecifiedColumn(t,5)}shiftIdxToBondType(t){return this.shiftIdxToSpecifiedColumn(t,4)}getBondBlockIdx(){return this.getNextLineIdx(this.fileContent.indexOf("M V30 BEGIN BOND"))}static validate(t){return-1!==t.indexOf("V3000")&&-1!==t.indexOf("M END")}parseAtomAndBondCounts(){let t=this.fileContent.indexOf("M V30 COUNTS ")+14,e=this.fileContent.indexOf(" ",t+1);const s=parseInt(this.fileContent.substring(t,e));return t=e+1,e=this.fileContent.indexOf(" ",t+1),{atomCount:s,bondCount:parseInt(this.fileContent.substring(t,e))}}}class m{constructor(){}static getInstance(t){if(c.validate(t))return new c(t);if(u.validate(t))return new u(t);throw new Error("Malformed molfile")}}var d=s(7228),g=s(2904);const p="Libraries",f="System:AppData/Bio/libraries/";async function y(){return await Promise.all((await n.dapi.files.list(f,!0,"")).map((async t=>t.fullPath.substring(f.length))))}let b=Promise.resolve();async function w(){let t;return b=b.then((async()=>{const e=await n.dapi.userDataStorage.getValue(p,"Settings",!0);t=e?JSON.parse(e):{exclude:[]},t.exclude=t.exclude instanceof Array?t.exclude:[],console.debug(`Bio: getUserLibSettings()\n${JSON.stringify(t,void 0,2)}`)})),await b,t}async function C(t){b=b.then((async()=>{console.debug(`Bio: setUserLibSettings()\n${JSON.stringify(t,void 0,2)}`),await n.dapi.userDataStorage.postValue(p,"Settings",JSON.stringify(t),!0)})),await b}async function v(){const t=o.dialog({title:"Manage files"}).add(o.fileBrowser({path:"System:AppData/Bio/libraries"}).root).addButton("OK",(()=>t.close())).show()}async function S(){const t=o.button("Manage",v),e=o.inputs([]),s=await y(),i=await w();for(const t of s){const s=o.boolInput(t,!i.exclude.includes(t),(()=>{1==s.value?i.exclude=i.exclude.filter((e=>e!=t)):i.exclude.includes(t)||i.exclude.push(t),C(i).then((async()=>{await M.instance.loadLibraries(!0),n.shell.info("Monomer library user settings saved.")}))}));e.append(s.root)}return new r.Widget(o.divV([e,o.div(t)]))}class T{constructor(t,e){this._monomers={},this._onChanged=new a.Subject,this._monomers=t,this.error=e}getMonomer(t,e){return t in this._monomers&&e in this._monomers[t]?this._monomers[t][e]:null}getPolymerTypes(){return Object.keys(this._monomers)}getMonomerMolsByPolymerType(t){const e={};return Object.keys(this._monomers[t]??{}).forEach((s=>{e[s]=this._monomers[t][s].molfile})),e}getMonomerSymbolsByType(t){return Object.keys(this._monomers[t])}getMonomerSymbolsByRGroup(t,e,s){let i=this.getMonomerSymbolsByType(e).map((t=>this.getMonomer(e,t)));return i=i.filter((t=>null!==t)),0===i.length?[]:(i=i.filter((e=>{if(!e?.rgroups)return!1;let s=e?.rgroups.length>=t;return m.getInstance(e.molfile).atomTypes.map(((t,e)=>"R#"===t?e:-1)).filter((t=>-1!==t)),s&&(s=!0),s})),i.map((t=>t?.symbol)))}get onChanged(){return this._onChanged}_updateInt(t){const e=t.getPolymerTypes(),s=this.getPolymerTypes();e.forEach((e=>{s.includes(e)||(this._monomers[e]={}),t.getMonomerSymbolsByType(e).forEach((s=>{this._monomers[e][s]=t.getMonomer(e,s)}))}))}update(t){this._updateInt(t),this._onChanged.next()}updateLibs(t,e=!1){e&&(this._monomers={});for(const e of t)e.error||this._updateInt(e);this._onChanged.next()}clear(){this._monomers={},this._onChanged.next()}}class M{constructor(){this._monomerLib=new T({}),this.loadLibrariesPromise=Promise.resolve()}getBioLib(){return this._monomerLib}async loadLibraries(t=!1){return this.loadLibrariesPromise=this.loadLibrariesPromise.then((async()=>{try{const[e,s]=await Promise.all([y(),w()]),i=e.filter((t=>!s.exclude.includes(t))),n=await Promise.all(i.map((t=>this.readLibrary(f,t).catch((e=>{const s=`Loading monomers from '${t}' error: ${e instanceof Error?e.message:e.toString()}`;return new T({},s)})))));this._monomerLib.updateLibs(n,t)}catch(t){const e=`Loading monomer libraries error: ${t instanceof Error?t.message:t.toString()}`;n.shell.warning(e);const s=t instanceof Error?t.stack:void 0;g._package.logger.error(e,void 0,s)}}))}async readLibrary(t,e){let s,i,o=[];const a=new r.FileSource(t);if(e.endsWith(".sdf"))1===r.Func.find({package:"Chem",name:"importSdf"}).length?(s=await a.readAsBytes(e),i=await n.functions.call("Chem:importSdf",{bytes:s}),o=(0,d.Xk)(i[0])):n.shell.warning("Chem package is not installed");else if(e.endsWith(".json")){const t=await a.readAsText(e);o=JSON.parse(t)}else{if(!e.endsWith(".csv"))throw new Error("Monomer library of unknown file format, supported formats: SDF, JSON, CSV");{const t=(l=await a.readCsv(e),Array.from({length:l.rowCount},((t,e)=>l.columns.names().reduce(((t,s)=>(t[s]=l.get(s,e),t)),{}))));if(!(0,d.eD)(t))throw new Error("Invalid format of CSV monomer lib");o=(0,d.Z)(t)}}var l;const h={},c=[];return o.forEach((t=>{c.includes(t.polymerType)||(h[t.polymerType]={},c.push(t.polymerType)),h[t.polymerType][t.symbol]=t})),new T(h)}static get instance(){return M._instance||(M._instance=new M),M._instance}}M._instance=null},525:(t,e,s)=>{"use strict";s.d(e,{K:()=>I});var i=s(4469),n=s(976),o=s(3870),r=s(8447),a=s(499),l=s(6098),h=s(8341),c=s(2568),u=s(3553),m=s(2904),d=s(3379),g=s.n(d),p=s(7795),f=s.n(p),y=s(569),b=s.n(y),w=s(3565),C=s.n(w),v=s(9216),S=s.n(v),T=s(4589),M=s.n(T),A=s(9564),E={};E.styleTagTransform=M(),E.setAttributes=C(),E.insert=b().bind(null,"head"),E.domAPI=f(),E.insertStyleElement=S(),g()(A.Z,E),A.Z&&A.Z.locals&&A.Z.locals;class x extends Error{constructor(t,e){super(t,e)}}async function I(t={}){return new Promise((async(e,s)=>{var r,a,l;t.clustersCol??(t.clustersCol=null),t.pepsea??(t.pepsea={}),(r=t.pepsea).method??(r.method=u.jB.pepsea.method),(a=t.pepsea).gapOpen??(a.gapOpen=u.jB.pepsea.gapOpen),(l=t.pepsea).gapExtend??(l.gapExtend=u.jB.pepsea.gapExtend);const c=t.col?.dataFrame??i.shell.t,m=t.col??c.columns.bySemType(n.SEMTYPE.MACROMOLECULE);if(null==m){const t="MSAError: dataset doesn't conain any 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h=t.toList();e&&(h=h.map((t=>N.clean(t).replace(/\-/g,""))));const c=t.length;o??(o=i.Column.string("Clusters",c).init("0")),o.type!=i.COLUMN_TYPE.STRING&&(o=o.convertTo(i.TYPE.STRING)),o.compact();const u=o.categories,m=o.getRawData(),d=new Array(u.length),g=new Array(u.length);for(let t=0;t<c;++t){const e=m[t];(d[e]??(d[e]=[])).push(h[t]),(g[e]??(g[e]=[])).push(t)}const p=await new E(["base/1.0.0",{tool:"kalign",version:L.WY,reinit:!0}]),f=i.Column.string(s,c);for(let t=0;t<u.length;++t){const e=O(d[t]);await p.fs.writeFile(_,e);const s=`${void 0!==r?` --gpo ${r}`:""}${void 0!==a?` --gpe ${a}`:""}${void 0!==l?` --tgpe ${l}`:""}`,i=await p.exec(`kalign ${_} -f fasta -o ${R}${s}`);console.warn(i);const o=await p.cat(R);if(!o)throw new Error("kalign output no result");const h=new n.i(o).sequencesArray,c=g[t];for(let t=0;t<h.length;++t)f.set(c[t],h[t])}const y=t.getTag(i.TAGS.UNITS),b=t.getTag("alphabet");return f.setTag(i.TAGS.UNITS,y),f.setTag("aligned","SEQ.MSA"),f.setTag("alphabet",b),f.semType=i.SEMTYPE.MACROMOLECULE,f}},8341:(t,e,s)=>{"use strict";s.d(e,{J:()=>a,f:()=>h});var i=s(4469),n=s(976),o=s(8447),r=s(3553);const a=["mafft --auto","mafft","linsi","ginsi","einsi","fftns","fftnsi","nwns","nwnsi"],l=["AlignedSeq","AlignedSubpeptide","HELM","ID","PolymerID"];async function h(t,e,s="ginsi",a=1.53,h=0,u=null){const m=await i.dapi.docker.dockerContainers.filter("bio").first();if("started"!==m.status&&"checking"!==m.status)return i.log.warning("PepSeA container has not started yet"),null;const d=t.length;u??(u=n.Column.int("Clusters",d).init(0)),u.type!=n.COLUMN_TYPE.STRING&&(u=u.convertTo(n.TYPE.STRING));const g=u.categories,p=new Array(g.length);for(let e=0;e<d;++e){const s=u.get(e);if(""===s)continue;const i=g.indexOf(s),n=t.get(e);n&&(p[i]??(p[i]=[])).push({ID:e.toString(),HELM:n})}const f=new Array(d);for(const t of p){const e=(await c(m.id,t,s,a,h)).Alignment;for(const t of e)f[parseInt(t.ID)]=Object.entries(t).filter((t=>!l.includes(t[0]))).map((t=>"-"!==t[1]?t[1]:"")).join(r.rs.SEPARATOR)}const y=n.Column.fromStrings(e,f);return y.setTag(n.TAGS.UNITS,o.r2.SEPARATOR),y.setTag("separator",r.rs.SEPARATOR),y.setTag("aligned","SEQ.MSA"),y.setTag("alphabet","UN"),y.setTag(".alphabetIsMultichar","true"),y.semType=n.SEMTYPE.MACROMOLECULE,y}async function c(t,e,s,n,o){const r={method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify(e)},a=`/align?method=${s}&gap_open=${n}&gap_extend=${o}`,l=await i.dapi.docker.dockerContainers.request(t,a,r);return JSON.parse(l??"{}")}},9943:(t,e,s)=>{"use strict";s.d(e,{C2:()=>u});var i=s(976),n=s(3870),o=s(4469),r=s(6414),a=s.n(r),l=s(8447),h=s(499);const c=60;function u(){const t=o.shell.tv.grid,e=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>!!t.column&&t.column.semType!==i.SEMTYPE.MACROMOLECULE)).toArray(),s=e.find((t=>-1!==t.name.toLowerCase().indexOf("id"))),r=s?[s.name]:[],u=n.multiChoiceInput("Seq id columns",r,e.map((t=>t.name))),d=a().count(0).take(t.columns.length).map((e=>t.columns.byIndex(e))).filter((t=>{const e=t.column;return!(!e||e.semType!==i.SEMTYPE.MACROMOLECULE)&&h.Cn.getOrCreate(e).isFasta()})).toArray(),g=d.length>0?d[0].name:[],p=n.choiceInput("Seq column",g,d.map((t=>t.name))),f=n.intInput("FASTA line width",c);n.dialog({title:"Save as FASTA"}).add(n.inputs([u,p,f])).onOK((()=>{const e=u.value?u.value.map((e=>t.columns.byName(e).column)):[],s=p.value?t.columns.byName(p.value).column:null,i=f.value??c;s||o.shell.warning("Seq column is mandatory to save as FASTA.");const n=function(t,e,s=c,i="\n"){const n=l.kB,o=[];for(let r=0;r<e.length;r++){const a=t.map((t=>t.get(r).toString())).join("|"),l=m(e.get(r),n,s);o.push(`>${a}${i}`);for(const t of l)o.push(`${t}${i}`)}return"".concat(...o)}(e,s,i),r=document.createElement("a");r.setAttribute("href",`data:text/plain;charset=utf-8,${encodeURIComponent(n)}`),r.setAttribute("download",`${t.dataFrame.name}.fasta`),r.click()})).show()}function m(t,e,s=c){const i=e(t);let n=0;const o=i.length,r=[];for(;n<o;){const t=a()(i).slice(n,n+s).toArray(),e=t.map((t=>t.length>1?`[${t}]`:t)).join("");r.push(e),n+=t.length}return r}},9416:(t,e,s)=>{"use strict";s.d(e,{n:()=>h});var i=s(4469),n=s(976),o=s(1061),r=s(2568),a=s(8457),l=s(3553);async function h(t,e){if(await(0,o.gw)(10),!(0,r.n)(e,"Sequence space"))return t;const s=(0,a.O)(e);s.name="splitToMonomers";const h=e.dataFrame;for(const t of s.columns)t.semType=l.Of.MONOMER,t.setTag("alphabet",e.getTag("alphabet"));const c=/(\d+)(?: \((\d+)\))?/,u=t=>{c.lastIndex=0;const e=t.match(c);return e?`${e[1]} (${parseInt(e[2]??0)+1})`:t};for(let t=0;t<s.columns.length;t++){const i=s.columns.byIndex(t);i.semType=l.Of.MONOMER,i.setTag("alphabet",e.getTag("alphabet"));const n=100;let o=0;for(;h.columns.byName(i.name)&&o<n;)i.name=u(i.name),o++;h.columns.add(i)}await i.data.detectSemanticTypes(h);for(let t=0;t<s.columns.length;t++){const e=s.columns.byIndex(t);e.setTag(n.TAGS.CELL_RENDERER,"Monomer"),e.setTag(".use-as-filter","false")}return h}},4293:(t,e,s)=>{"use strict";s.d(e,{B:()=>o,Y:()=>r});var i=s(4469),n=s(976);function o(){const t=i.shell.t.columns.bySemTypeAll(n.SEMTYPE.MACROMOLECULE);if(null!==t)return t;i.shell.error("Current table does not contain macromolecules")}function r(t,e){t.innerHTML="",t.append(e)}},833:(t,e,s)=>{"use strict";s.d(e,{bo:()=>g,OZ:()=>v});var i=s(4469),n=s(3870),o=s(976),r=s(6414),a=s.n(r),l=s(701),h=s(499),c=s(8447),u=s(9298);function m(t){var e;return"string"==typeof t||t instanceof String?t:("object"==typeof t||t instanceof Object)&&"$thrownJsError"in t?m(t.$thrownJsError):t instanceof Error?null!==(e=t.stack)&&void 0!==e?e:t.message:t.toString()}var d,g,p=s(7958),f=s(2904);HTMLCanvasElement.prototype.getCursorPosition=function(t,e){const s=this.getBoundingClientRect();return new o.Point((t.clientX-s.left)*e,(t.clientY-s.top)*e)},o.Rect.prototype.contains=function(t,e){return this.left<=t&&t<=this.right&&this.top<=e&&e<=this.bottom};class y{constructor(t=0,e){this.count=t,this.bounds=e}}class b{get label(){return this._label?this._label:this.name}constructor(t,e,s,i){this.pos=t,this.name=e,this._freqs=s??{},i?.rowCount&&(this.rowCount=i.rowCount),i?.sumForHeightCalc&&(this.sumForHeightCalc=i.sumForHeightCalc),i?.label&&(this._label=i.label)}getMonomers(){return Object.keys(this._freqs)}hasMonomer(t){return t in this._freqs}getFreq(t){let e=this._freqs[t];return e||(e=this._freqs[t]=new y),e}getMonomerAt(t,e){const s=Object.entries(this._freqs).find((([s,i])=>i.bounds.contains(t,e)));return s?s[0]:void 0}calcHeights(t){this.rowCount=0;for(const[t,e]of Object.entries(this._freqs))this.rowCount+=e.count;if(this.sumForHeightCalc=0,t===u.ES.Entropy)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=-t*Math.log2(t)}else if(t===u.ES.full)for(const[t,e]of Object.entries(this._freqs)){const t=e.count/this.rowCount;this.sumForHeightCalc+=t}}calcScreen(t,e,s,i,n,r,a,l,h,c){const m=n==u.ES.Entropy?i*(r-this.sumForHeightCalc)/r:i;let d=c*h+(i-m-1);const g=Object.entries(this._freqs).sort(((e,s)=>t(e[0])||t(s[0])?t(e[0])&&t(s[0])?0:t(e[0])?-1:1:s[1].count-e[1].count));for(const t of g){const i=t[1],n=m*i.count/this.rowCount;i.bounds=new o.Rect((e-s)*h*a,d,l*h,n),d+=n}}render(t,e,s,i,n,o){for(const[r,a]of Object.entries(this._freqs))if(!e(r)){const e=(0,c.GU)(r,5),l=a.bounds,h=l.left;t.resetTransform(),t.strokeStyle="lightgray",t.lineWidth=1,t.rect(h,l.top,l.width,l.height),t.fillStyle=o.get(r)??o.get("other"),t.textAlign="left",t.font=s;const u=t.measureText(e);t.setTransform(l.width/u.width,0,0,l.height/n,h,l.top),t.fillText(e,0,-i)}}}!function(t){t.STYLE="Style",t.BEHAVIOR="Behavior",t.LAYOUT="Layout",t.DATA="Data"}(d||(d={})),function(t){t.sequenceColumnName="sequenceColumnName",t.startPositionName="startPositionName",t.endPositionName="endPositionName",t.skipEmptySequences="skipEmptySequences",t.skipEmptyPositions="skipEmptyPositions",t.shrinkEmptyTail="shrinkEmptyTail",t.backgroundColor="backgroundColor",t.positionHeight="positionHeight",t.positionWidth="positionWidth",t.verticalAlignment="verticalAlignment",t.horizontalAlignment="horizontalAlignment",t.fixWidth="fixWidth",t.fitArea="fitArea",t.minHeight="minHeight",t.maxHeight="maxHeight",t.showPositionLabels="showPositionLabels",t.positionMarginState="positionMarginState",t.positionMargin="positionMargin",t.filterSource="filterSource"}(g||(g={}));const w=u.vS;var C;!function(t){t[t.None=0]="None",t[t.Render=1]="Render",t[t.Layout=1]="Layout",t[t.Freqs=2]="Freqs"}(C||(C={}));class v extends o.JsViewer{get positionWidthWithMargin(){return this._positionWidthWithMargin}get Length(){return this.skipEmptyPositions?this.positions.length:this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0}get positionMarginValue(){return this.positionMarginState===u.dE.AUTO&&!0===this.unitsHandler.getAlphabetIsMultichar()||this.positionMarginState===u.dE.ON?this.positionMargin:0}constructor(){super(),this.viewed=!1,this.viewerId=-1,this.initialized=!1,this.cp=null,this.seqCol=null,this.positions=[],this.visibleSlider=!1,this.allowResize=!0,this.turnOfResizeForOneSetValue=!1,this.backgroundColor=4294967295,this.positionMargin=0,this.positionNames=[],this.positionLabels=void 0,this.startPosition=-1,this.endPosition=-1,this.error=null,this.viewPromise=Promise.resolve(),this.detachPromise=Promise.resolve(),this.setDataInProgress=!1,this.viewSubs=[],this._onSizeChanged=new l.Subject,this._onFreqsCalculated=new l.Subject,this._onLayoutCalculated=new l.Subject,this.requestedRenderLevel=C.Freqs,this.renderRequest=new l.Subject,this.viewerId=v.viewerCount,v.viewerCount+=1,this.textBaseline="top",this.unitsHandler=null,this.sequenceColumnName=this.string(g.sequenceColumnName,w.sequenceColumnName,{category:d.DATA}),this.startPositionName=this.string(g.startPositionName,w.startPositionName,{category:d.DATA}),this.endPositionName=this.string(g.endPositionName,w.endPositionName,{category:d.DATA}),this.skipEmptySequences=this.bool(g.skipEmptySequences,w.skipEmptySequences,{category:d.DATA}),this.skipEmptyPositions=this.bool(g.skipEmptyPositions,w.skipEmptyPositions,{category:d.DATA}),this.shrinkEmptyTail=this.bool(g.shrinkEmptyTail,w.shrinkEmptyTail,{category:d.DATA}),this.backgroundColor=this.int(g.backgroundColor,w.backgroundColor,{category:d.STYLE}),this.positionHeight=this.string(g.positionHeight,w.positionHeight,{category:d.STYLE,choices:Object.values(u.ES)}),this._positionWidth=this.positionWidth=this.float(g.positionWidth,w.positionWidth,{category:d.STYLE}),this.verticalAlignment=this.string(g.verticalAlignment,w.verticalAlignment,{category:d.LAYOUT,choices:Object.values(u.vw)}),this.horizontalAlignment=this.string(g.horizontalAlignment,w.horizontalAlignment,{category:d.LAYOUT,choices:Object.values(u.iD)}),this.fixWidth=this.bool(g.fixWidth,w.fixWidth,{category:d.LAYOUT,userEditable:!1}),this.fitArea=this.bool(g.fitArea,w.fitArea,{category:d.LAYOUT}),this.minHeight=this.float(g.minHeight,w.minHeight,{category:d.LAYOUT}),this.maxHeight=this.float(g.maxHeight,w.maxHeight,{category:d.LAYOUT}),this.showPositionLabels=this.bool(g.showPositionLabels,w.showPositionLabels,{category:d.LAYOUT}),this.positionMarginState=this.string(g.positionMarginState,w.positionMarginState,{category:d.LAYOUT,choices:Object.values(u.dE)});let t=0;"auto"===this.positionMarginState&&(t=4),this.positionMargin=this.int(g.positionMargin,t,{category:d.LAYOUT,min:0,max:16}),this.filterSource=this.string(g.filterSource,w.filterSource,{category:d.BEHAVIOR,choices:Object.values(u.Ct)}),this.slider=n.rangeSlider(0,100,0,20,!1,{style:"barbell"}),this.canvas=n.canvas(),this.canvas.classList.value="bio-wl-canvas",this.canvas.style.width="100%"}setData(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.setData(), in`),this.viewPromise=this.viewPromise.then((async()=>{if(!this.setDataInProgress){this.setDataInProgress=!0;try{this.viewed&&(this.renderRequestSub.unsubscribe(),await this.destroyView(),this.viewed=!1),await this.detachPromise,this.updateSeqCol(),this.viewed||(await this.buildView(),this.viewed=!0)}catch(t){const[e,s]=(0,p.yf)(t);i.shell.error(e),f._package.logger.error(e,void 0,s)}finally{this.setDataInProgress=!1}}}))}async destroyView(){for(const t of this.viewSubs)t.unsubscribe();this.viewSubs=[];const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView( dataFrame = ${t} ) start`),this.host.remove(),this.msgHost=void 0,this.host=void 0,f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.destroyView() end`)}async buildView(){const t=this.dataFrame?"data":"null";f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView( dataFrame = ${t} ) start`),window.devicePixelRatio,this.viewSubs.push(o.debounce(this.renderRequest).subscribe(this.renderRequestOnDebounce.bind(this))),this.helpUrl="/help/visualize/viewers/web-logo.md",this.msgHost=n.div("No message",{classes:"bio-wl-msg"}),this.msgHost.style.display="none",this.canvas=n.canvas(),this.canvas.style.width="100%",this.slider.root.style.position="absolute",this.slider.root.style.zIndex="999",this.slider.root.style.display="none",this.slider.root.style.height="0.7em",this.visibleSlider=!1,this.host=n.div([this.msgHost,this.canvas],{classes:"bio-wl-host",style:{display:"flex",flexDirection:"row",flexWrap:"wrap"}}),this.root.append(this.host),this.root.append(this.slider.root),this.error&&(this.msgHost.innerText=this.error.message,n.tooltip.bind(this.msgHost,this.error.stack),this.msgHost.style.setProperty("display",null)),this.dataFrame&&(this.viewSubs.push(this.dataFrame.filter.onChanged.subscribe(this.dataFrameFilterOnChanged.bind(this))),this.viewSubs.push(this.dataFrame.selection.onChanged.subscribe(this.dataFrameSelectionOnChanged.bind(this)))),this.viewSubs.push(n.onSizeChanged(this.root).subscribe(this.rootOnSizeChanged.bind(this))),this.viewSubs.push(this.slider.onValuesChanged.subscribe(this.sliderOnValuesChanged.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousemove").subscribe(this.canvasOnMouseMove.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"mousedown").subscribe(this.canvasOnMouseDown.bind(this))),this.viewSubs.push((0,l.fromEvent)(this.canvas,"wheel").subscribe(this.canvasOnWheel.bind(this))),await this.render(C.Freqs,"buildView"),f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.buildView() end`)}rootOnSizeChanged(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.rootOnSizeChanged(), start `),this.render(C.Layout,"rootOnSizeChanged")}updateSeqCol(){if(this.dataFrame&&(this.seqCol=this.sequenceColumnName?this.dataFrame.col(this.sequenceColumnName):null,null==this.seqCol&&(this.seqCol=(0,c.up)(this.dataFrame),this.sequenceColumnName=this.seqCol?this.seqCol.name:null),this.seqCol)){try{this.unitsHandler=h.Cn.getOrCreate(this.seqCol),this.cp=(0,c.dQ)(this.seqCol),this.updatePositions(),this.error=null}catch(t){throw this.seqCol=null,this.error=t instanceof Error?t:new Error(t.toString()),t}this.seqCol||(this.unitsHandler=null,this.positionNames=[],this.positionLabels=[],this.startPosition=-1,this.endPosition=-1,this.cp=null)}}updatePositions(){if(!this.seqCol)return;const t=this.getFilter(),e=0===t.trueCount?this.unitsHandler.maxLength:a().enumerate(this.unitsHandler.splitted).map((([e,s])=>t.get(s)&&e?e.length:0)).reduce(((t,e)=>Math.max(t,e)),0),s=this.seqCol.getTag(".positionNames"),i=this.seqCol.getTag(".positionLabels");this.positionNames=s?s.split(c.CI).map((t=>t.trim())):[...Array(e).keys()].map((t=>`${t+1}`)),this.positionLabels=i?i.split(c.CI).map((t=>t.trim())):void 0,this.startPosition=this.startPositionName&&this.positionNames&&this.positionNames.includes(this.startPositionName)?this.positionNames.indexOf(this.startPositionName):0,this.endPosition=this.endPositionName&&this.positionNames&&this.positionNames.includes(this.endPositionName)?this.positionNames.indexOf(this.endPositionName):e-1,this.render(C.Freqs,"updatePositions")}getFilter(){let t;switch(this.filterSource){case u.Ct.Filtered:t=this.dataFrame.filter;break;case u.Ct.Selected:t=0===this.dataFrame.selection.trueCount?this.dataFrame.filter:this.dataFrame.selection}return t}setSliderVisibility(t){t?(this.slider.root.style.display="inherit",this.visibleSlider=!0):(this.slider.root.style.display="none",this.visibleSlider=!1)}calcLayout(t){this.host&&this.canvas&&this.slider&&(this.host.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this.canvas.classList.remove("bio-wl-fixWidth","bio-wl-fitArea"),this._positionWidth=this.positionWidth,this._positionMargin=this.positionMargin,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue,this.fixWidth?this.calcLayoutFixWidth(t):this.fitArea?this.calcLayoutFitArea(t):this.calcLayoutNoFitArea(t),this.slider.root.style.width=`${this.host.clientWidth}px`)}calcLayoutFixWidth(t){if(!this.host||!this.canvas||!this.slider)return;this.host.classList.add("bio-wl-fixWidth"),this.canvas.classList.add("bio-wl-fitArea");const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight);this.host.style.justifyContent=u.iD.LEFT,this.host.style.removeProperty("margin-left"),this.host.style.removeProperty("margin-top"),this.host.style.width=this.canvas.style.width=`${e}px`,this.host.style.height=this.canvas.style.height=`${s}px`,this.host.style.left=this.canvas.style.left="0",this.host.style.top=this.canvas.style.top="0",this.host.style.setProperty("overflow","hidden","important"),this.slider.root.style.display="none",this.slider.setValues(0,Math.max(0,this.Length-1),0,Math.max(0,this.Length-1)),this.canvas.width=e*t,this.canvas.height=s*t}calcLayoutNoFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidthWithMargin*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=Math.min(this.root.clientWidth,e);this.canvas.style.width=`${i}px`,this.canvas.style.height=`${s}px`,this.host.style.width=`${i}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${i+6}px`),this.host.style.width=`${this.host}px`;const n=e>i;if(this.setSliderVisibility(n),n){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,Math.max(this.Length-.001),t,e)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=i*t,this.canvas.height=s*t}calcLayoutFitArea(t){if(!this.host||!this.canvas||!this.slider)return;const e=this._positionWidth*this.Length,s=Math.min(Math.max(this.minHeight,this.root.clientHeight),this.maxHeight),i=e>0?(this.root.clientWidth-this.positionMarginValue*this.Length)/e:0,n=this.root.clientHeight/s,o=Math.max(1,Math.min(i,n));this._positionWidth=this.positionWidth*o,this._positionWidthWithMargin=this._positionWidth+this.positionMarginValue;const r=(this._positionWidth+this.positionMarginValue)*this.Length,a=o*s,l=Math.min(this.root.clientWidth,r);this.canvas.style.width=`${l}px`,this.canvas.style.height=`${a}px`,this.host.style.width=`${l}px`,this.host.style.height=`${this.root.clientHeight}px`,this.host.style.justifyContent=this.horizontalAlignment,this.host.style.alignContent=this.verticalAlignment===u.vw.TOP?"start":this.verticalAlignment===u.vw.MIDDLE?"center":this.verticalAlignment===u.vw.BOTTOM?"end":"inherit",this.root.clientHeight<this.minHeight&&(this.host.style.alignContent="start",this.host.style.width=`${l+6}px`),this.host.style.width=`${this.host}px`;const h=r>l;if(this.setSliderVisibility(h),h){this.slider.root.style.removeProperty("display"),this.host.style.justifyContent="left",this.host.style.height=this.root.clientHeight-this.slider.root.offsetHeight+"px",this.slider.root.style.top=`${this.host.offsetHeight}px`;let t=Math.min(Math.max(0,this.slider.min),this.Length-.001),e=Math.min(Math.max(0,this.slider.max),this.Length-.001);const s=this.root.clientWidth/this._positionWidthWithMargin;e=Math.min(Math.max(t,0)+s,this.Length-.001),t=Math.max(0,Math.min(e,this.Length-.001)-s),this.slider.setValues(0,Math.max(0,this.Length-.001),t,e)}else this.slider.setValues(0,Math.max(0,this.Length-.001),0,Math.max(0,this.Length-.001));this.canvas.width=l*t,this.canvas.height=a*t}onPropertyChanged(t){switch(super.onPropertyChanged(t),t.name){case g.sequenceColumnName:this.updateSeqCol();break;case g.sequenceColumnName:case g.startPositionName:case g.endPositionName:case g.filterSource:case g.shrinkEmptyTail:case g.skipEmptyPositions:case g.positionHeight:this.updatePositions();break;case g.minHeight:case g.maxHeight:case g.positionWidth:case g.showPositionLabels:case g.fixWidth:case g.fitArea:case g.horizontalAlignment:case g.verticalAlignment:case g.positionMargin:case g.positionMarginState:this.render(C.Layout,`onPropertyChanged(${t.name})`);break;case g.backgroundColor:this.render(C.Render,`onPropertyChanged(${t.name})`)}}onTableAttached(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.onTableAttached(), `),super.onTableAttached(),this.setData()}async detach(){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.detach(), `);const t=super.detach.bind(this);this.detachPromise=this.detachPromise.then((async()=>{await this.viewPromise,this.setDataInProgress||(this.viewed&&(await this.destroyView(),this.viewed=!1),t())}))}get onSizeChanged(){return this._onSizeChanged}get onFreqsCalculated(){return this._onFreqsCalculated}get onLayoutCalculated(){return this._onLayoutCalculated}getMonomer(t,e){const s=t.x,i=Math.floor(t.x/(this._positionWidthWithMargin*e)+Math.floor(this.slider.min)),n=this.positions[i];if(void 0===n)return[i,null,null];const o=n.getMonomerAt(s,t.y);return void 0===o?[i,null,null]:[i,o,n.getFreq(o)]}_nullSequence(t="X"){return this.skipEmptySequences?"":new Array(this.Length).fill(t).join("")}_removeEmptyPositions(){this.skipEmptyPositions&&(this.positions=a()(this.positions).filter((t=>{const e=this.unitsHandler.defaultGapSymbol;return!t.hasMonomer(e)||t.getFreq(e).count!==t.rowCount})).toArray())}render(t,e){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render( recalcLevelVal=${t}, reason='${e}' )`),this.requestedRenderLevel=Math.max(this.requestedRenderLevel,t),this.renderRequest.next(this.requestedRenderLevel)}async renderInt(t){if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( renderLevel=${t} ), start `),this.msgHost&&(this.seqCol&&!this.cp?(this.msgHost.innerText=`Unknown palette (column semType: '${this.seqCol.semType}').`,this.msgHost.style.display=""):this.msgHost.style.display="none"),!this.seqCol||!this.dataFrame||!this.cp||null==this.host||null==this.slider)return;const e=window.devicePixelRatio,s=this.showPositionLabels?12:0;if(t>=C.Freqs&&(()=>{if(f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateFreqsInt(), start `),!this.host||!this.seqCol||!this.dataFrame)return;const t=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.unitsHandler=h.Cn.getOrCreate(this.seqCol);const e=this.startPosition<=this.endPosition?this.endPosition-this.startPosition+1:0;this.positions=new Array(e);for(let e=0;e<t;e++){const t=this.positionNames[this.startPosition+e],s=this.positionLabels?this.positionLabels[this.startPosition+e]:void 0;this.positions[e]=new b(this.startPosition+e,t,{},{label:s})}const s=this.getFilter(),i=this.dataFrame.rowCount,n=this.unitsHandler.splitted;for(let e=0;e<i;++e)if(s.get(e)){const s=n[e];for(let e=0;e<t;++e){const t=s[this.startPosition+e]||this.unitsHandler.defaultGapSymbol;this.positions[e].getFreq(t).count++}}for(let e=0;e<t;e++)this.positions[e].calcHeights(this.positionHeight);this._removeEmptyPositions(),this._onFreqsCalculated.next()})(),this.calcLayout(e),0===this.positions.length||-1===this.startPosition||-1===this.endPosition)return;t>=C.Layout&&((t,e)=>{f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), start `);const s=this.canvas.height-e*t,n=this.getAlphabetSize();this.positionHeight==u.ES.Entropy&&null==n&&i.shell.error("WebLogo: alphabet is undefined.");const o=Math.log2(n);for(let i=Math.floor(this.slider.min);i<=Math.floor(this.slider.max);++i)i in this.positions?this.positions[i].calcScreen((t=>this.unitsHandler.isGap(t)),i,this.slider.min,s,this.positionHeight,o,this._positionWidthWithMargin,this._positionWidth,t,e):console.warn(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt() this.positions.length = ${this.positions.length}, jPos = ${i}`);f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.calculateLayoutInt(), end `),this._onLayoutCalculated.next()})(window.devicePixelRatio,s);const n=this.canvas.getContext("2d");if(!n)return;this.Length,n.resetTransform(),n.fillStyle=function(t){const e=o.Color.a(t);return`#${(16777215&t).toString(16).padStart(6,"0")}`+e.toString(16).padStart(2,"0")}(this.backgroundColor),n.fillRect(0,0,this.canvas.width,this.canvas.height),n.textBaseline=this.textBaseline;const r=10*e;n.resetTransform(),n.fillStyle="black",n.textAlign="center",n.font=`${r.toFixed(1)}px Roboto, Roboto Local, sans-serif`;const a=Math.max(...this.positions.map((t=>n.measureText(t.name).width))),l=a<this._positionWidth*e-2?1:(this._positionWidth*e-2)/a;s>0&&function(t,e,s,i,n,o,r,a){for(let l=Math.floor(r);l<=Math.floor(a);l++){const a=o[l];t.resetTransform(),t.setTransform(s,0,0,1,(l-r)*i*e+n*e/2,0),t.fillText(a.label,0,1)}}(n,e,l,this._positionWidthWithMargin,this._positionWidth,this.positions,this.slider.min,this.slider.max);for(let t=Math.floor(this.slider.min);t<=Math.floor(this.slider.max);t++)this.positions[t].render(n,(t=>this.unitsHandler.isGap(t)),"16px Roboto, Roboto Local, sans-serif",.25,12.2,this.cp);f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.render.renderInt( recalcLevel=${t} ), end`)}renderRequestOnDebounce(t){this.requestedRenderLevel=C.None,this.renderInt(t).catch((t=>{const[e,s]=(0,p.yf)(t);f._package.logger.error(e,void 0,s)}))}getAlphabetSize(){return this.unitsHandler?.getAlphabetSize()??0}sliderOnValuesChanged(t){try{const t={minRange:this.slider.minRange,min:this.slider.min,max:this.slider.max,maxRange:this.slider.maxRange};f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged( ${JSON.stringify(t)} ), start`),this.render(C.Layout,"sliderOnValuesChanged")}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.sliderOnValuesChanged() error:\n`+e)}}dataFrameFilterOnChanged(t){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterChanged()`);try{this.updatePositions(),this.filterSource===u.Ct.Filtered&&this.render(C.Freqs,"dataFrameFilterOnChanged")}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameFilterOnChanged() error:\n`+e)}}dataFrameSelectionOnChanged(t){f._package.logger.debug(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged()`);try{this.filterSource===u.Ct.Selected&&this.render(C.Freqs,"dataFrameSelectionOnChanged")}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.dataFrameSelectionOnChanged() error:\n`+e)}}canvasOnMouseMove(t){const e=window.devicePixelRatio;try{const s=t,i=this.canvas.getCursorPosition(s,e),[o,r]=this.getMonomer(i,e);if(this.dataFrame&&this.seqCol&&r){const t=this.positions[o],e=function(t,e,s,i,n){let o=0,r=-1;for(;-1!=(r=s.findNext(r,!0));){const t=e.splitted[r],s=n.pos;(s<t.length?t[s]:null)===i&&o++}return o}(this.dataFrame,this.unitsHandler,this.getFilter(),r,t),i=n.div([n.div(`${r}`),n.div(`${e} rows`)]);n.tooltip.show(i,s.x+16,s.y+16)}else n.tooltip.hide()}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseMove() error:\n`+e)}}canvasOnMouseDown(t){try{const e=t,s=window.devicePixelRatio,[i,n]=this.getMonomer(this.canvas.getCursorPosition(e,s),s);if(this.dataFrame&&this.seqCol&&this.unitsHandler&&n){const t=this.positions[i],e=o.BitSet.create(this.dataFrame.selection.length,(e=>function(t,e,s,i,n,o){const r=e.splitted[i],a=o.pos<r.length?r[o.pos]:null;return a===n||""===a&&n===e.defaultGapSymbol}(this.dataFrame,this.unitsHandler,this.getFilter(),e,n,t)));this.dataFrame.selection.init((t=>e.get(t)))}}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnMouseDown() error:\n`+e)}}canvasOnWheel(t){const e=window.devicePixelRatio;try{if(!this.visibleSlider)return;const s=this.canvas.width/(this._positionWidthWithMargin*e),i=t.deltaY/100*Math.max(Math.floor(s/5),1);this.slider.scrollBy(this.slider.min+i)}catch(t){const e=m(t);f._package.logger.error(`Bio: WebLogoViewer<${this.viewerId}>.canvasOnWheel() error:\n`+e)}}}v.residuesSet="nucleotides",v.viewerCount=0},4413:(t,e,s)=>{"use strict";s.d(e,{ST:()=>g});var i=s(3870),n=s(976),o=s(4469),r=s(6414),a=s.n(r),l=s(7983),h=s(701),c=s(4293),u=s(8447),m=s(1061);const d=rxjs.operators;class g extends n.Filter{get calculating(){return"initial"==this.loader.style.display}set calculating(t){this.loader.style.display=t?"initial":"none"}get filterSummary(){return this.bioFilter.substructure}get isFiltering(){return super.isFiltering&&""!==this.bioFilter.substructure}get isReadyToApplyFilter(){return!this.calculating&&null!=this.bitset}get _debounceTime(){if(null==this.column)return 1e3;const t=this.column.length;return t<500?0:t>1e4?1e3:Math.floor((t-500)/9500*1e3)}constructor(){super(),this.bioFilter=null,this.bitset=null,this.loader=i.loader(),this.notation=void 0,this.root=i.divV([]),this.calculating=!1}attach(t){super.attach(t),this.column=t.columns.bySemType(n.SEMTYPE.MACROMOLECULE),this.columnName??(this.columnName=this.column?.name),this.notation??(this.notation=this.column?.getTag(n.TAGS.UNITS)),this.bioFilter=this.notation===u.r2.FASTA?new f:this.notation===u.r2.SEPARATOR?new y(this.column.getTag("separator")):new b,this.root.appendChild(this.bioFilter.filterPanel),this.root.appendChild(this.loader),this.onBioFilterChangedSubs?.unsubscribe();let e=this.bioFilter.onChanged;e=e.pipe((0,d.debounceTime)(this._debounceTime)),this.onBioFilterChangedSubs=e.subscribe((async t=>await this._onInputChanged())),this.subs.push(o.events.onResetFilterRequest.subscribe((t=>{this.bioFilter?.resetFilter()})))}detach(){super.detach()}applyFilter(){this.bitset&&!this.isDetached&&this.dataFrame?.filter.and(this.bitset)}saveState(){const t=super.saveState();return t.bioSubstructure=this.bioFilter?.substructure,t}applyState(t){super.applyState(t),t.bioSubstructure&&(this.bioFilter.substructure=t.bioSubstructure);const e=this;t.bioSubstructure&&setTimeout((function(){e._onInputChanged()}),1e3)}async _onInputChanged(){if(this.isFiltering){if(a()(this.dataFrame.rows.filters).has(`${this.columnName}: ${this.filterSummary}`))return;this.calculating=!0;try{this.bitset=await(this.bioFilter?.substructureSearch(this.column)),this.calculating=!1,this.dataFrame?.rows.requestFilter()}finally{this.calculating=!1}}else this.bitset=null,this.dataFrame?.rows.requestFilter()}}class p{constructor(){this.onChanged=new h.Subject}get filterPanel(){return new HTMLElement}get substructure(){return""}set substructure(t){}async substructureSearch(t){return null}}class f extends p{constructor(){super(),this.substructureInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Substructure"})}get filterPanel(){return this.substructureInput.root}get substructure(){return this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,l.pf)(this.substructure,t)}resetFilter(){this.substructureInput.value=""}}class y extends f{constructor(t){super(),this.colSeparator="",this.separatorInput=i.stringInput("","",(()=>{this.onChanged.next()}),{placeholder:"Separator"}),this.colSeparator=t,this.separatorInput.value=t}get filterPanel(){return i.divV([this.substructureInput.root,this.separatorInput.root])}get substructure(){return this.separatorInput.value&&this.separatorInput.value!==this.colSeparator?this.substructureInput.value.replaceAll(this.separatorInput.value,this.colSeparator):this.substructureInput.value}set substructure(t){this.substructureInput.value=t}async substructureSearch(t){return(0,l.pf)(this.substructure,t,this.colSeparator)}}class b extends p{constructor(){super(),this._filterPanel=i.div("",{style:{cursor:"pointer"}}),this.helmSubstructure="",this.init()}async init(){this.helmEditor=await o.functions.call("HELM:helmWebEditor"),await i.tools.waitForElementInDom(this._filterPanel),this.updateFilterPanel(),this._filterPanel.addEventListener("click",(t=>{const{editorDiv:e,webEditor:s}=this.helmEditor.createWebEditor(this.helmSubstructure);i.dialog({showHeader:!1,showFooter:!0}).add(e).onOK((()=>{const t=s.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.helmSubstructure=t,this.updateFilterPanel(this.substructure),setTimeout((()=>{this.onChanged.next()}),10)})).show({modal:!0,fullScreen:!0})})),i.onSizeChanged(this._filterPanel).subscribe((t=>{const e=this.helmEditor.webEditor.canvas.getHelm(!0).replace(/<\/span>/g,"").replace(/<span style='background:#bbf;'>/g,"");this.updateFilterPanel(e)}))}get filterPanel(){return this._filterPanel}get substructure(){return this.helmSubstructure}set substructure(t){this.helmEditor.editor.setHelm(t)}updateFilterPanel(t){const e=this._filterPanel.parentElement.clientWidth<100?100:this._filterPanel.parentElement.clientWidth,s=e/2;if(t)(0,c.Y)(this._filterPanel,this.helmEditor.host),this.helmEditor.editor.setHelm(t),this.helmEditor.resizeEditor(e,s);else{const t=i.divText("Click to edit","helm-substructure-filter");(0,c.Y)(this._filterPanel,t)}}async substructureSearch(t){i.setUpdateIndicator(this._filterPanel,!0),await(0,m.gw)(10);const e=await(0,l.QF)(this.substructure,t);return i.setUpdateIndicator(this._filterPanel,!1),e}resetFilter(){console.debug("Bio: HelmFilter.resetFilter()"),this.helmSubstructure="",this.updateFilterPanel(this.substructure)}}},3336:t=>{"use strict";t.exports=$},976:t=>{"use strict";t.exports=DG},4469:t=>{"use strict";t.exports=grok},701:t=>{"use strict";t.exports=rxjs},3870:t=>{"use strict";t.exports=ui},6414:t=>{"use strict";t.exports=wu}},e={};function s(i){var n=e[i];if(void 0!==n)return n.exports;var o=e[i]={id:i,exports:{}};return t[i].call(o.exports,o,o.exports,s),o.exports}s.m=t,s.n=t=>{var e=t&&t.__esModule?()=>t.default:()=>t;return s.d(e,{a:e}),e},s.d=(t,e)=>{for(var i in e)s.o(e,i)&&!s.o(t,i)&&Object.defineProperty(t,i,{enumerable:!0,get:e[i]})},s.u=t=>t+".js",s.g=function(){if("object"==typeof globalThis)return globalThis;try{return this||new Function("return this")()}catch(t){if("object"==typeof window)return window}}(),s.o=(t,e)=>Object.prototype.hasOwnProperty.call(t,e),s.r=t=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(t,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(t,"__esModule",{value:!0})},(()=>{var t;s.g.importScripts&&(t=s.g.location+"");var e=s.g.document;if(!t&&e&&(e.currentScript&&(t=e.currentScript.src),!t)){var i=e.getElementsByTagName("script");if(i.length)for(var n=i.length-1;n>-1&&!t;)t=i[n--].src}if(!t)throw new Error("Automatic publicPath is not supported in this browser");t=t.replace(/#.*$/,"").replace(/\?.*$/,"").replace(/\/[^\/]+$/,"/"),s.p=t})(),s.b=document.baseURI||self.location.href,s.nc=void 0;var i=s(2904);bio=i})();
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