@claude-flow/plugin-healthcare-clinical 3.0.0-alpha.1

package/dist/bridges/gnn-bridge.js

@@ -0,0 +1,534 @@
+/**
+ * GNN Bridge - Healthcare Clinical Plugin
+ *
+ * Provides Graph Neural Network capabilities for clinical pathway
+ * analysis and drug interaction detection. Integrates with
+ * ruvector-gnn-wasm for efficient graph-based reasoning.
+ *
+ * Use Cases:
+ * - Clinical pathway recommendations
+ * - Drug interaction network analysis
+ * - Comorbidity pattern detection
+ * - Treatment outcome prediction
+ */
+/**
+ * Default logger
+ */
+const defaultLogger = {
+    debug: (msg, meta) => console.debug(`[gnn-bridge] ${msg}`, meta),
+    info: (msg, meta) => console.info(`[gnn-bridge] ${msg}`, meta),
+    warn: (msg, meta) => console.warn(`[gnn-bridge] ${msg}`, meta),
+    error: (msg, meta) => console.error(`[gnn-bridge] ${msg}`, meta),
+};
+/**
+ * Drug interaction graph with known interactions
+ */
+class DrugInteractionGraph {
+    interactions = new Map();
+    severityOrder = ['contraindicated', 'major', 'moderate', 'minor'];
+    constructor() {
+        this.loadKnownInteractions();
+    }
+    /**
+     * Load known drug interactions
+     * In production, this would load from a clinical database
+     */
+    loadKnownInteractions() {
+        // Sample known drug-drug interactions
+        const knownInteractions = [
+            {
+                drug1: 'warfarin',
+                drug2: 'aspirin',
+                severity: 'major',
+                description: 'Increased risk of bleeding when warfarin is combined with aspirin',
+                mechanism: 'Both drugs affect blood clotting through different mechanisms',
+                clinicalEffect: 'Enhanced anticoagulation, increased bleeding risk',
+                management: 'Monitor INR closely, consider alternative antiplatelet agent',
+            },
+            {
+                drug1: 'metformin',
+                drug2: 'contrast_dye',
+                severity: 'major',
+                description: 'Risk of lactic acidosis with iodinated contrast media',
+                mechanism: 'Contrast-induced nephropathy may impair metformin clearance',
+                clinicalEffect: 'Potential for severe metabolic acidosis',
+                management: 'Hold metformin 48 hours before and after contrast administration',
+            },
+            {
+                drug1: 'simvastatin',
+                drug2: 'clarithromycin',
+                severity: 'contraindicated',
+                description: 'Significantly increased risk of myopathy and rhabdomyolysis',
+                mechanism: 'Clarithromycin inhibits CYP3A4, increasing simvastatin levels',
+                clinicalEffect: 'Muscle damage, potential kidney failure',
+                management: 'Avoid combination, use azithromycin if macrolide needed',
+            },
+            {
+                drug1: 'lisinopril',
+                drug2: 'potassium',
+                severity: 'moderate',
+                description: 'Increased risk of hyperkalemia',
+                mechanism: 'ACE inhibitors reduce aldosterone, preserving potassium',
+                clinicalEffect: 'Elevated serum potassium levels',
+                management: 'Monitor potassium levels regularly',
+            },
+            {
+                drug1: 'ssri',
+                drug2: 'maoi',
+                severity: 'contraindicated',
+                description: 'Risk of serotonin syndrome',
+                mechanism: 'Combined serotonergic activity',
+                clinicalEffect: 'Potentially fatal serotonin toxicity',
+                management: 'Allow 2-week washout period between drugs',
+            },
+        ];
+        for (const interaction of knownInteractions) {
+            const key1 = this.getInteractionKey(interaction.drug1, interaction.drug2);
+            const key2 = this.getInteractionKey(interaction.drug2, interaction.drug1);
+            if (!this.interactions.has(key1)) {
+                this.interactions.set(key1, []);
+            }
+            this.interactions.get(key1).push(interaction);
+            if (!this.interactions.has(key2)) {
+                this.interactions.set(key2, []);
+            }
+            this.interactions.get(key2).push({
+                ...interaction,
+                drug1: interaction.drug2,
+                drug2: interaction.drug1,
+            });
+        }
+    }
+    /**
+     * Check for drug interactions
+     */
+    checkInteractions(medications, severityFilter = 'all') {
+        const results = [];
+        const normalized = medications.map(m => m.toLowerCase().trim());
+        for (let i = 0; i < normalized.length; i++) {
+            for (let j = i + 1; j < normalized.length; j++) {
+                const drug1 = normalized[i];
+                const drug2 = normalized[j];
+                const key = this.getInteractionKey(drug1, drug2);
+                const interactions = this.interactions.get(key);
+                if (interactions) {
+                    for (const interaction of interactions) {
+                        if (severityFilter === 'all' || this.meetsSeverityFilter(interaction.severity, severityFilter)) {
+                            results.push(interaction);
+                        }
+                    }
+                }
+            }
+        }
+        // Sort by severity
+        results.sort((a, b) => {
+            return this.severityOrder.indexOf(a.severity) - this.severityOrder.indexOf(b.severity);
+        });
+        return results;
+    }
+    getInteractionKey(drug1, drug2) {
+        return [drug1.toLowerCase(), drug2.toLowerCase()].sort().join('::');
+    }
+    meetsSeverityFilter(severity, filter) {
+        if (filter === 'all')
+            return true;
+        const filterIndex = this.severityOrder.indexOf(filter);
+        const severityIndex = this.severityOrder.indexOf(severity);
+        return severityIndex <= filterIndex;
+    }
+}
+/**
+ * Clinical pathway graph for treatment recommendations
+ */
+class ClinicalPathwayGraph {
+    pathways = new Map();
+    constructor() {
+        this.loadStandardPathways();
+    }
+    /**
+     * Load standard clinical pathways
+     * In production, load from clinical guideline database
+     */
+    loadStandardPathways() {
+        const samplePathways = [
+            {
+                id: 'dm2-management',
+                name: 'Type 2 Diabetes Management',
+                diagnosis: 'E11',
+                version: '2024.1',
+                evidenceLevel: 'systematic-review',
+                steps: [
+                    {
+                        id: 'dm2-1',
+                        name: 'Initial Assessment',
+                        description: 'Complete metabolic panel, HbA1c, lipid panel',
+                        type: 'assessment',
+                        timing: 'Day 1',
+                    },
+                    {
+                        id: 'dm2-2',
+                        name: 'Lifestyle Modification',
+                        description: 'Diet counseling, exercise prescription',
+                        type: 'intervention',
+                        timing: 'Weeks 1-12',
+                        prerequisites: ['dm2-1'],
+                    },
+                    {
+                        id: 'dm2-3',
+                        name: 'Metformin Initiation',
+                        description: 'Start metformin if HbA1c > 6.5%',
+                        type: 'decision',
+                        timing: 'Week 1',
+                        prerequisites: ['dm2-1'],
+                    },
+                    {
+                        id: 'dm2-4',
+                        name: 'Glycemic Monitoring',
+                        description: 'Regular HbA1c monitoring every 3 months',
+                        type: 'monitoring',
+                        timing: 'Ongoing',
+                        prerequisites: ['dm2-2', 'dm2-3'],
+                    },
+                ],
+            },
+            {
+                id: 'htn-management',
+                name: 'Hypertension Management',
+                diagnosis: 'I10',
+                version: '2024.1',
+                evidenceLevel: 'rct',
+                steps: [
+                    {
+                        id: 'htn-1',
+                        name: 'Blood Pressure Confirmation',
+                        description: 'Confirm elevated BP with multiple readings',
+                        type: 'assessment',
+                        timing: 'Days 1-7',
+                    },
+                    {
+                        id: 'htn-2',
+                        name: 'Risk Stratification',
+                        description: 'Assess cardiovascular risk factors',
+                        type: 'assessment',
+                        timing: 'Day 1',
+                    },
+                    {
+                        id: 'htn-3',
+                        name: 'Lifestyle Modification',
+                        description: 'DASH diet, sodium restriction, exercise',
+                        type: 'intervention',
+                        timing: 'Weeks 1-8',
+                        prerequisites: ['htn-1', 'htn-2'],
+                    },
+                    {
+                        id: 'htn-4',
+                        name: 'ACE Inhibitor or ARB',
+                        description: 'First-line pharmacotherapy',
+                        type: 'decision',
+                        timing: 'Week 1-2',
+                        prerequisites: ['htn-2'],
+                    },
+                ],
+            },
+        ];
+        for (const pathway of samplePathways) {
+            this.pathways.set(pathway.diagnosis, pathway);
+            this.pathways.set(pathway.id, pathway);
+        }
+    }
+    /**
+     * Find pathway by diagnosis code
+     */
+    findPathway(diagnosis) {
+        // Try exact match first
+        let pathway = this.pathways.get(diagnosis);
+        if (pathway)
+            return pathway;
+        // Try ICD-10 category match (first 3 characters)
+        const category = diagnosis.substring(0, 3);
+        pathway = this.pathways.get(category);
+        if (pathway)
+            return pathway;
+        // Search by diagnosis prefix
+        for (const [key, value] of this.pathways) {
+            if (diagnosis.startsWith(key) || key.startsWith(diagnosis)) {
+                return value;
+            }
+        }
+        return undefined;
+    }
+    /**
+     * Get all available pathways
+     */
+    getAllPathways() {
+        const seen = new Set();
+        const results = [];
+        for (const pathway of this.pathways.values()) {
+            if (!seen.has(pathway.id)) {
+                seen.add(pathway.id);
+                results.push(pathway);
+            }
+        }
+        return results;
+    }
+}
+/**
+ * Healthcare GNN Bridge implementation
+ */
+export class HealthcareGNNBridge {
+    wasmModule = null;
+    graphPtr = 0;
+    config;
+    logger;
+    nodes = new Map();
+    edges = [];
+    nodeIdToIndex = new Map();
+    drugInteractionGraph;
+    clinicalPathwayGraph;
+    initialized = false;
+    constructor(config, logger) {
+        this.config = {
+            hiddenDimensions: config?.hiddenDimensions ?? 256,
+            numLayers: config?.numLayers ?? 3,
+            dropout: config?.dropout ?? 0.1,
+            aggregationType: config?.aggregationType ?? 'mean',
+        };
+        this.logger = logger ?? defaultLogger;
+        this.drugInteractionGraph = new DrugInteractionGraph();
+        this.clinicalPathwayGraph = new ClinicalPathwayGraph();
+    }
+    /**
+     * Initialize the GNN bridge
+     */
+    async initialize(config) {
+        if (config) {
+            this.config = { ...this.config, ...config };
+        }
+        try {
+            const wasmPath = await this.resolveWasmPath();
+            if (wasmPath) {
+                this.wasmModule = await this.loadWasmModule(wasmPath);
+                this.logger.info('GNN WASM module initialized', {
+                    hiddenDimensions: this.config.hiddenDimensions,
+                    numLayers: this.config.numLayers,
+                });
+            }
+            else {
+                this.logger.warn('WASM module not available, using fallback implementation');
+            }
+            this.initialized = true;
+        }
+        catch (error) {
+            this.logger.warn('Failed to initialize WASM, using fallback', {
+                error: error instanceof Error ? error.message : String(error),
+            });
+            this.initialized = true;
+        }
+    }
+    /**
+     * Load a graph into the GNN
+     */
+    async loadGraph(nodes, edges) {
+        if (!this.initialized) {
+            throw new Error('GNN bridge not initialized');
+        }
+        // Clear existing graph
+        this.nodes.clear();
+        this.edges = [];
+        this.nodeIdToIndex.clear();
+        // Index nodes
+        let idx = 0;
+        for (const node of nodes) {
+            this.nodes.set(node.id, node);
+            this.nodeIdToIndex.set(node.id, idx++);
+        }
+        // Store edges
+        this.edges = edges;
+        if (this.wasmModule) {
+            // Create WASM graph
+            const featureDim = nodes[0]?.features.length ?? 128;
+            this.graphPtr = this.wasmModule.create_graph(nodes.length, edges.length, featureDim);
+            // Add nodes
+            for (const node of nodes) {
+                const nodeIdx = this.nodeIdToIndex.get(node.id);
+                this.wasmModule.add_node(this.graphPtr, nodeIdx, new Float32Array(node.features));
+            }
+            // Add edges
+            for (const edge of edges) {
+                const sourceIdx = this.nodeIdToIndex.get(edge.source);
+                const targetIdx = this.nodeIdToIndex.get(edge.target);
+                if (sourceIdx !== undefined && targetIdx !== undefined) {
+                    this.wasmModule.add_edge(this.graphPtr, sourceIdx, targetIdx, 0, edge.weight ?? 1.0);
+                }
+            }
+        }
+        this.logger.info('Graph loaded', { nodes: nodes.length, edges: edges.length });
+    }
+    /**
+     * Predict optimal pathway between nodes
+     */
+    async predictPathway(startNode, endNode, constraints) {
+        if (!this.initialized) {
+            throw new Error('GNN bridge not initialized');
+        }
+        const startTime = performance.now();
+        if (this.wasmModule && this.graphPtr) {
+            const startIdx = this.nodeIdToIndex.get(startNode);
+            const endIdx = this.nodeIdToIndex.get(endNode);
+            if (startIdx !== undefined && endIdx !== undefined) {
+                const maxHops = constraints?.maxHops ?? 10;
+                const pathIndices = this.wasmModule.predict_path(this.graphPtr, startIdx, endIdx, maxHops);
+                const path = Array.from(pathIndices)
+                    .map(idx => this.getNodeIdByIndex(idx))
+                    .filter((id) => id !== undefined);
+                return {
+                    path,
+                    confidence: 0.85,
+                    alternativePaths: [],
+                    riskScore: 0.2,
+                };
+            }
+        }
+        // Fallback: BFS path finding
+        const path = this.bfsPath(startNode, endNode, constraints);
+        const duration = performance.now() - startTime;
+        this.logger.debug('Pathway predicted', { startNode, endNode, pathLength: path.length, durationMs: duration });
+        return {
+            path,
+            confidence: path.length > 0 ? 0.75 : 0,
+            alternativePaths: [],
+            riskScore: this.calculatePathRisk(path),
+        };
+    }
+    /**
+     * Analyze interactions between nodes
+     */
+    async analyzeInteractions(nodeIds) {
+        if (!this.initialized) {
+            throw new Error('GNN bridge not initialized');
+        }
+        // Use drug interaction graph for medication analysis
+        const drugInteractions = this.drugInteractionGraph.checkInteractions(nodeIds);
+        const interactions = drugInteractions.map(di => ({
+            nodes: [di.drug1, di.drug2],
+            type: 'drug-drug',
+            strength: this.severityToStrength(di.severity),
+            direction: 'bidirectional',
+        }));
+        const riskFactors = drugInteractions
+            .filter(di => di.severity === 'major' || di.severity === 'contraindicated')
+            .map(di => `${di.drug1} + ${di.drug2}: ${di.description}`);
+        const recommendations = drugInteractions.map(di => di.management ?? 'Monitor closely');
+        return {
+            interactions,
+            riskFactors,
+            recommendations: [...new Set(recommendations)],
+        };
+    }
+    /**
+     * Get clinical pathway for a diagnosis
+     */
+    getClinicalPathway(diagnosis) {
+        return this.clinicalPathwayGraph.findPathway(diagnosis);
+    }
+    /**
+     * Check drug interactions
+     */
+    checkDrugInteractions(medications, severityFilter = 'all') {
+        return this.drugInteractionGraph.checkInteractions(medications, severityFilter);
+    }
+    /**
+     * Cleanup resources
+     */
+    destroy() {
+        if (this.wasmModule && this.graphPtr) {
+            this.wasmModule.free_graph(this.graphPtr);
+        }
+        this.nodes.clear();
+        this.edges = [];
+        this.nodeIdToIndex.clear();
+        this.initialized = false;
+    }
+    // Private methods
+    async resolveWasmPath() {
+        try {
+            // Dynamic import with type assertion for optional WASM package
+            const module = await import(/* webpackIgnore: true */ 'ruvector-gnn-wasm');
+            return module.default ?? null;
+        }
+        catch {
+            return null;
+        }
+    }
+    async loadWasmModule(wasmPath) {
+        const module = await import(wasmPath);
+        await module.default();
+        return module;
+    }
+    getNodeIdByIndex(index) {
+        for (const [id, idx] of this.nodeIdToIndex) {
+            if (idx === index)
+                return id;
+        }
+        return undefined;
+    }
+    bfsPath(start, end, constraints) {
+        const visited = new Set();
+        const queue = [{ node: start, path: [start] }];
+        const excludeNodes = new Set(constraints?.excludeNodes ?? []);
+        const maxHops = constraints?.maxHops ?? 10;
+        while (queue.length > 0) {
+            const current = queue.shift();
+            if (current.node === end) {
+                return current.path;
+            }
+            if (current.path.length > maxHops)
+                continue;
+            if (visited.has(current.node))
+                continue;
+            visited.add(current.node);
+            // Find adjacent nodes
+            for (const edge of this.edges) {
+                let neighbor = null;
+                if (edge.source === current.node)
+                    neighbor = edge.target;
+                if (edge.target === current.node)
+                    neighbor = edge.source;
+                if (neighbor && !visited.has(neighbor) && !excludeNodes.has(neighbor)) {
+                    queue.push({ node: neighbor, path: [...current.path, neighbor] });
+                }
+            }
+        }
+        return [];
+    }
+    calculatePathRisk(path) {
+        if (path.length === 0)
+            return 1.0;
+        let risk = 0;
+        for (let i = 0; i < path.length - 1; i++) {
+            const edge = this.edges.find(e => (e.source === path[i] && e.target === path[i + 1]) ||
+                (e.target === path[i] && e.source === path[i + 1]));
+            if (edge && edge.weight !== undefined) {
+                risk += 1 - edge.weight;
+            }
+        }
+        return Math.min(risk / path.length, 1.0);
+    }
+    severityToStrength(severity) {
+        switch (severity) {
+            case 'contraindicated': return 1.0;
+            case 'major': return 0.8;
+            case 'moderate': return 0.5;
+            case 'minor': return 0.2;
+            default: return 0.5;
+        }
+    }
+}
+/**
+ * Create a new GNN bridge instance
+ */
+export function createGNNBridge(config, logger) {
+    return new HealthcareGNNBridge(config, logger);
+}
+export default HealthcareGNNBridge;
+//# sourceMappingURL=gnn-bridge.js.map

package/dist/bridges/gnn-bridge.js.map

@@ -0,0 +1 @@
+{"version":3,"file":"gnn-bridge.js","sourceRoot":"","sources":["../../src/bridges/gnn-bridge.ts"],"names":[],"mappings":"AAAA;;;;;;;;;;;;GAYG;AAeH;;GAEG;AACH,MAAM,aAAa,GAAW;IAC5B,KAAK,EAAE,CAAC,GAAW,EAAE,IAA8B,EAAE,EAAE,CAAC,OAAO,CAAC,KAAK,CAAC,gBAAgB,GAAG,EAAE,EAAE,IAAI,CAAC;IAClG,IAAI,EAAE,CAAC,GAAW,EAAE,IAA8B,EAAE,EAAE,CAAC,OAAO,CAAC,IAAI,CAAC,gBAAgB,GAAG,EAAE,EAAE,IAAI,CAAC;IAChG,IAAI,EAAE,CAAC,GAAW,EAAE,IAA8B,EAAE,EAAE,CAAC,OAAO,CAAC,IAAI,CAAC,gBAAgB,GAAG,EAAE,EAAE,IAAI,CAAC;IAChG,KAAK,EAAE,CAAC,GAAW,EAAE,IAA8B,EAAE,EAAE,CAAC,OAAO,CAAC,KAAK,CAAC,gBAAgB,GAAG,EAAE,EAAE,IAAI,CAAC;CACnG,CAAC;AAgBF;;GAEG;AACH,MAAM,oBAAoB;IAChB,YAAY,GAAmC,IAAI,GAAG,EAAE,CAAC;IAChD,aAAa,GAA0B,CAAC,iBAAiB,EAAE,OAAO,EAAE,UAAU,EAAE,OAAO,CAAC,CAAC;IAE1G;QACE,IAAI,CAAC,qBAAqB,EAAE,CAAC;IAC/B,CAAC;IAED;;;OAGG;IACK,qBAAqB;QAC3B,sCAAsC;QACtC,MAAM,iBAAiB,GAAsB;YAC3C;gBACE,KAAK,EAAE,UAAU;gBACjB,KAAK,EAAE,SAAS;gBAChB,QAAQ,EAAE,OAAO;gBACjB,WAAW,EAAE,mEAAmE;gBAChF,SAAS,EAAE,+DAA+D;gBAC1E,cAAc,EAAE,mDAAmD;gBACnE,UAAU,EAAE,8DAA8D;aAC3E;YACD;gBACE,KAAK,EAAE,WAAW;gBAClB,KAAK,EAAE,cAAc;gBACrB,QAAQ,EAAE,OAAO;gBACjB,WAAW,EAAE,uDAAuD;gBACpE,SAAS,EAAE,6DAA6D;gBACxE,cAAc,EAAE,yCAAyC;gBACzD,UAAU,EAAE,kEAAkE;aAC/E;YACD;gBACE,KAAK,EAAE,aAAa;gBACpB,KAAK,EAAE,gBAAgB;gBACvB,QAAQ,EAAE,iBAAiB;gBAC3B,WAAW,EAAE,6DAA6D;gBAC1E,SAAS,EAAE,+DAA+D;gBAC1E,cAAc,EAAE,yCAAyC;gBACzD,UAAU,EAAE,yDAAyD;aACtE;YACD;gBACE,KAAK,EAAE,YAAY;gBACnB,KAAK,EAAE,WAAW;gBAClB,QAAQ,EAAE,UAAU;gBACpB,WAAW,EAAE,gCAAgC;gBAC7C,SAAS,EAAE,yDAAyD;gBACpE,cAAc,EAAE,iCAAiC;gBACjD,UAAU,EAAE,oCAAoC;aACjD;YACD;gBACE,KAAK,EAAE,MAAM;gBACb,KAAK,EAAE,MAAM;gBACb,QAAQ,EAAE,iBAAiB;gBAC3B,WAAW,EAAE,4BAA4B;gBACzC,SAAS,EAAE,gCAAgC;gBAC3C,cAAc,EAAE,sCAAsC;gBACtD,UAAU,EAAE,2CAA2C;aACxD;SACF,CAAC;QAEF,KAAK,MAAM,WAAW,IAAI,iBAAiB,EAAE,CAAC;YAC5C,MAAM,IAAI,GAAG,IAAI,CAAC,iBAAiB,CAAC,WAAW,CAAC,KAAK,EAAE,WAAW,CAAC,KAAK,CAAC,CAAC;YAC1E,MAAM,IAAI,GAAG,IAAI,CAAC,iBAAiB,CAAC,WAAW,CAAC,KAAK,EAAE,WAAW,CAAC,KAAK,CAAC,CAAC;YAE1E,IAAI,CAAC,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,CAAC,EAAE,CAAC;gBACjC,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,EAAE,EAAE,CAAC,CAAC;YAClC,CAAC;YACD,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,CAAE,CAAC,IAAI,CAAC,WAAW,CAAC,CAAC;YAE/C,IAAI,CAAC,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,CAAC,EAAE,CAAC;gBACjC,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,EAAE,EAAE,CAAC,CAAC;YAClC,CAAC;YACD,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,IAAI,CAAE,CAAC,IAAI,CAAC;gBAChC,GAAG,WAAW;gBACd,KAAK,EAAE,WAAW,CAAC,KAAK;gBACxB,KAAK,EAAE,WAAW,CAAC,KAAK;aACzB,CAAC,CAAC;QACL,CAAC;IACH,CAAC;IAED;;OAEG;IACH,iBAAiB,CAAC,WAAqB,EAAE,iBAAyB,KAAK;QACrE,MAAM,OAAO,GAAsB,EAAE,CAAC;QACtC,MAAM,UAAU,GAAG,WAAW,CAAC,GAAG,CAAC,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,WAAW,EAAE,CAAC,IAAI,EAAE,CAAC,CAAC;QAEhE,KAAK,IAAI,CAAC,GAAG,CAAC,EAAE,CAAC,GAAG,UAAU,CAAC,MAAM,EAAE,CAAC,EAAE,EAAE,CAAC;YAC3C,KAAK,IAAI,CAAC,GAAG,CAAC,GAAG,CAAC,EAAE,CAAC,GAAG,UAAU,CAAC,MAAM,EAAE,CAAC,EAAE,EAAE,CAAC;gBAC/C,MAAM,KAAK,GAAG,UAAU,CAAC,CAAC,CAAE,CAAC;gBAC7B,MAAM,KAAK,GAAG,UAAU,CAAC,CAAC,CAAE,CAAC;gBAC7B,MAAM,GAAG,GAAG,IAAI,CAAC,iBAAiB,CAAC,KAAK,EAAE,KAAK,CAAC,CAAC;gBAEjD,MAAM,YAAY,GAAG,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,GAAG,CAAC,CAAC;gBAChD,IAAI,YAAY,EAAE,CAAC;oBACjB,KAAK,MAAM,WAAW,IAAI,YAAY,EAAE,CAAC;wBACvC,IAAI,cAAc,KAAK,KAAK,IAAI,IAAI,CAAC,mBAAmB,CAAC,WAAW,CAAC,QAAQ,EAAE,cAAc,CAAC,EAAE,CAAC;4BAC/F,OAAO,CAAC,IAAI,CAAC,WAAW,CAAC,CAAC;wBAC5B,CAAC;oBACH,CAAC;gBACH,CAAC;YACH,CAAC;QACH,CAAC;QAED,mBAAmB;QACnB,OAAO,CAAC,IAAI,CAAC,CAAC,CAAC,EAAE,CAAC,EAAE,EAAE;YACpB,OAAO,IAAI,CAAC,aAAa,CAAC,OAAO,CAAC,CAAC,CAAC,QAAQ,CAAC,GAAG,IAAI,CAAC,aAAa,CAAC,OAAO,CAAC,CAAC,CAAC,QAAQ,CAAC,CAAC;QACzF,CAAC,CAAC,CAAC;QAEH,OAAO,OAAO,CAAC;IACjB,CAAC;IAEO,iBAAiB,CAAC,KAAa,EAAE,KAAa;QACpD,OAAO,CAAC,KAAK,CAAC,WAAW,EAAE,EAAE,KAAK,CAAC,WAAW,EAAE,CAAC,CAAC,IAAI,EAAE,CAAC,IAAI,CAAC,IAAI,CAAC,CAAC;IACtE,CAAC;IAEO,mBAAmB,CAAC,QAA6B,EAAE,MAAc;QACvE,IAAI,MAAM,KAAK,KAAK;YAAE,OAAO,IAAI,CAAC;QAClC,MAAM,WAAW,GAAG,IAAI,CAAC,aAAa,CAAC,OAAO,CAAC,MAA6B,CAAC,CAAC;QAC9E,MAAM,aAAa,GAAG,IAAI,CAAC,aAAa,CAAC,OAAO,CAAC,QAAQ,CAAC,CAAC;QAC3D,OAAO,aAAa,IAAI,WAAW,CAAC;IACtC,CAAC;CACF;AAED;;GAEG;AACH,MAAM,oBAAoB;IAChB,QAAQ,GAAiC,IAAI,GAAG,EAAE,CAAC;IAE3D;QACE,IAAI,CAAC,oBAAoB,EAAE,CAAC;IAC9B,CAAC;IAED;;;OAGG;IACK,oBAAoB;QAC1B,MAAM,cAAc,GAAsB;YACxC;gBACE,EAAE,EAAE,gBAAgB;gBACpB,IAAI,EAAE,4BAA4B;gBAClC,SAAS,EAAE,KAAK;gBAChB,OAAO,EAAE,QAAQ;gBACjB,aAAa,EAAE,mBAAmB;gBAClC,KAAK,EAAE;oBACL;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,oBAAoB;wBAC1B,WAAW,EAAE,8CAA8C;wBAC3D,IAAI,EAAE,YAAY;wBAClB,MAAM,EAAE,OAAO;qBAChB;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,wBAAwB;wBAC9B,WAAW,EAAE,wCAAwC;wBACrD,IAAI,EAAE,cAAc;wBACpB,MAAM,EAAE,YAAY;wBACpB,aAAa,EAAE,CAAC,OAAO,CAAC;qBACzB;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,sBAAsB;wBAC5B,WAAW,EAAE,iCAAiC;wBAC9C,IAAI,EAAE,UAAU;wBAChB,MAAM,EAAE,QAAQ;wBAChB,aAAa,EAAE,CAAC,OAAO,CAAC;qBACzB;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,qBAAqB;wBAC3B,WAAW,EAAE,yCAAyC;wBACtD,IAAI,EAAE,YAAY;wBAClB,MAAM,EAAE,SAAS;wBACjB,aAAa,EAAE,CAAC,OAAO,EAAE,OAAO,CAAC;qBAClC;iBACF;aACF;YACD;gBACE,EAAE,EAAE,gBAAgB;gBACpB,IAAI,EAAE,yBAAyB;gBAC/B,SAAS,EAAE,KAAK;gBAChB,OAAO,EAAE,QAAQ;gBACjB,aAAa,EAAE,KAAK;gBACpB,KAAK,EAAE;oBACL;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,6BAA6B;wBACnC,WAAW,EAAE,4CAA4C;wBACzD,IAAI,EAAE,YAAY;wBAClB,MAAM,EAAE,UAAU;qBACnB;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,qBAAqB;wBAC3B,WAAW,EAAE,oCAAoC;wBACjD,IAAI,EAAE,YAAY;wBAClB,MAAM,EAAE,OAAO;qBAChB;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,wBAAwB;wBAC9B,WAAW,EAAE,yCAAyC;wBACtD,IAAI,EAAE,cAAc;wBACpB,MAAM,EAAE,WAAW;wBACnB,aAAa,EAAE,CAAC,OAAO,EAAE,OAAO,CAAC;qBAClC;oBACD;wBACE,EAAE,EAAE,OAAO;wBACX,IAAI,EAAE,sBAAsB;wBAC5B,WAAW,EAAE,4BAA4B;wBACzC,IAAI,EAAE,UAAU;wBAChB,MAAM,EAAE,UAAU;wBAClB,aAAa,EAAE,CAAC,OAAO,CAAC;qBACzB;iBACF;aACF;SACF,CAAC;QAEF,KAAK,MAAM,OAAO,IAAI,cAAc,EAAE,CAAC;YACrC,IAAI,CAAC,QAAQ,CAAC,GAAG,CAAC,OAAO,CAAC,SAAS,EAAE,OAAO,CAAC,CAAC;YAC9C,IAAI,CAAC,QAAQ,CAAC,GAAG,CAAC,OAAO,CAAC,EAAE,EAAE,OAAO,CAAC,CAAC;QACzC,CAAC;IACH,CAAC;IAED;;OAEG;IACH,WAAW,CAAC,SAAiB;QAC3B,wBAAwB;QACxB,IAAI,OAAO,GAAG,IAAI,CAAC,QAAQ,CAAC,GAAG,CAAC,SAAS,CAAC,CAAC;QAC3C,IAAI,OAAO;YAAE,OAAO,OAAO,CAAC;QAE5B,iDAAiD;QACjD,MAAM,QAAQ,GAAG,SAAS,CAAC,SAAS,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC;QAC3C,OAAO,GAAG,IAAI,CAAC,QAAQ,CAAC,GAAG,CAAC,QAAQ,CAAC,CAAC;QACtC,IAAI,OAAO;YAAE,OAAO,OAAO,CAAC;QAE5B,6BAA6B;QAC7B,KAAK,MAAM,CAAC,GAAG,EAAE,KAAK,CAAC,IAAI,IAAI,CAAC,QAAQ,EAAE,CAAC;YACzC,IAAI,SAAS,CAAC,UAAU,CAAC,GAAG,CAAC,IAAI,GAAG,CAAC,UAAU,CAAC,SAAS,CAAC,EAAE,CAAC;gBAC3D,OAAO,KAAK,CAAC;YACf,CAAC;QACH,CAAC;QAED,OAAO,SAAS,CAAC;IACnB,CAAC;IAED;;OAEG;IACH,cAAc;QACZ,MAAM,IAAI,GAAG,IAAI,GAAG,EAAU,CAAC;QAC/B,MAAM,OAAO,GAAsB,EAAE,CAAC;QAEtC,KAAK,MAAM,OAAO,IAAI,IAAI,CAAC,QAAQ,CAAC,MAAM,EAAE,EAAE,CAAC;YAC7C,IAAI,CAAC,IAAI,CAAC,GAAG,CAAC,OAAO,CAAC,EAAE,CAAC,EAAE,CAAC;gBAC1B,IAAI,CAAC,GAAG,CAAC,OAAO,CAAC,EAAE,CAAC,CAAC;gBACrB,OAAO,CAAC,IAAI,CAAC,OAAO,CAAC,CAAC;YACxB,CAAC;QACH,CAAC;QAED,OAAO,OAAO,CAAC;IACjB,CAAC;CACF;AAED;;GAEG;AACH,MAAM,OAAO,mBAAmB;IACtB,UAAU,GAAyB,IAAI,CAAC;IACxC,QAAQ,GAAW,CAAC,CAAC;IACrB,MAAM,CAAY;IAClB,MAAM,CAAS;IACf,KAAK,GAAyB,IAAI,GAAG,EAAE,CAAC;IACxC,KAAK,GAAc,EAAE,CAAC;IACtB,aAAa,GAAwB,IAAI,GAAG,EAAE,CAAC;IAC/C,oBAAoB,CAAuB;IAC3C,oBAAoB,CAAuB;IAE5C,WAAW,GAAG,KAAK,CAAC;IAE3B,YAAY,MAA2B,EAAE,MAAe;QACtD,IAAI,CAAC,MAAM,GAAG;YACZ,gBAAgB,EAAE,MAAM,EAAE,gBAAgB,IAAI,GAAG;YACjD,SAAS,EAAE,MAAM,EAAE,SAAS,IAAI,CAAC;YACjC,OAAO,EAAE,MAAM,EAAE,OAAO,IAAI,GAAG;YAC/B,eAAe,EAAE,MAAM,EAAE,eAAe,IAAI,MAAM;SACnD,CAAC;QACF,IAAI,CAAC,MAAM,GAAG,MAAM,IAAI,aAAa,CAAC;QACtC,IAAI,CAAC,oBAAoB,GAAG,IAAI,oBAAoB,EAAE,CAAC;QACvD,IAAI,CAAC,oBAAoB,GAAG,IAAI,oBAAoB,EAAE,CAAC;IACzD,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,UAAU,CAAC,MAAkB;QACjC,IAAI,MAAM,EAAE,CAAC;YACX,IAAI,CAAC,MAAM,GAAG,EAAE,GAAG,IAAI,CAAC,MAAM,EAAE,GAAG,MAAM,EAAE,CAAC;QAC9C,CAAC;QAED,IAAI,CAAC;YACH,MAAM,QAAQ,GAAG,MAAM,IAAI,CAAC,eAAe,EAAE,CAAC;YAC9C,IAAI,QAAQ,EAAE,CAAC;gBACb,IAAI,CAAC,UAAU,GAAG,MAAM,IAAI,CAAC,cAAc,CAAC,QAAQ,CAAC,CAAC;gBACtD,IAAI,CAAC,MAAM,CAAC,IAAI,CAAC,6BAA6B,EAAE;oBAC9C,gBAAgB,EAAE,IAAI,CAAC,MAAM,CAAC,gBAAgB;oBAC9C,SAAS,EAAE,IAAI,CAAC,MAAM,CAAC,SAAS;iBACjC,CAAC,CAAC;YACL,CAAC;iBAAM,CAAC;gBACN,IAAI,CAAC,MAAM,CAAC,IAAI,CAAC,0DAA0D,CAAC,CAAC;YAC/E,CAAC;YAED,IAAI,CAAC,WAAW,GAAG,IAAI,CAAC;QAC1B,CAAC;QAAC,OAAO,KAAK,EAAE,CAAC;YACf,IAAI,CAAC,MAAM,CAAC,IAAI,CAAC,2CAA2C,EAAE;gBAC5D,KAAK,EAAE,KAAK,YAAY,KAAK,CAAC,CAAC,CAAC,KAAK,CAAC,OAAO,CAAC,CAAC,CAAC,MAAM,CAAC,KAAK,CAAC;aAC9D,CAAC,CAAC;YACH,IAAI,CAAC,WAAW,GAAG,IAAI,CAAC;QAC1B,CAAC;IACH,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,SAAS,CAAC,KAAgB,EAAE,KAAgB;QAChD,IAAI,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC;YACtB,MAAM,IAAI,KAAK,CAAC,4BAA4B,CAAC,CAAC;QAChD,CAAC;QAED,uBAAuB;QACvB,IAAI,CAAC,KAAK,CAAC,KAAK,EAAE,CAAC;QACnB,IAAI,CAAC,KAAK,GAAG,EAAE,CAAC;QAChB,IAAI,CAAC,aAAa,CAAC,KAAK,EAAE,CAAC;QAE3B,cAAc;QACd,IAAI,GAAG,GAAG,CAAC,CAAC;QACZ,KAAK,MAAM,IAAI,IAAI,KAAK,EAAE,CAAC;YACzB,IAAI,CAAC,KAAK,CAAC,GAAG,CAAC,IAAI,CAAC,EAAE,EAAE,IAAI,CAAC,CAAC;YAC9B,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,IAAI,CAAC,EAAE,EAAE,GAAG,EAAE,CAAC,CAAC;QACzC,CAAC;QAED,cAAc;QACd,IAAI,CAAC,KAAK,GAAG,KAAK,CAAC;QAEnB,IAAI,IAAI,CAAC,UAAU,EAAE,CAAC;YACpB,oBAAoB;YACpB,MAAM,UAAU,GAAG,KAAK,CAAC,CAAC,CAAC,EAAE,QAAQ,CAAC,MAAM,IAAI,GAAG,CAAC;YACpD,IAAI,CAAC,QAAQ,GAAG,IAAI,CAAC,UAAU,CAAC,YAAY,CAAC,KAAK,CAAC,MAAM,EAAE,KAAK,CAAC,MAAM,EAAE,UAAU,CAAC,CAAC;YAErF,YAAY;YACZ,KAAK,MAAM,IAAI,IAAI,KAAK,EAAE,CAAC;gBACzB,MAAM,OAAO,GAAG,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,IAAI,CAAC,EAAE,CAAE,CAAC;gBACjD,IAAI,CAAC,UAAU,CAAC,QAAQ,CAAC,IAAI,CAAC,QAAQ,EAAE,OAAO,EAAE,IAAI,YAAY,CAAC,IAAI,CAAC,QAAQ,CAAC,CAAC,CAAC;YACpF,CAAC;YAED,YAAY;YACZ,KAAK,MAAM,IAAI,IAAI,KAAK,EAAE,CAAC;gBACzB,MAAM,SAAS,GAAG,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,IAAI,CAAC,MAAM,CAAC,CAAC;gBACtD,MAAM,SAAS,GAAG,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,IAAI,CAAC,MAAM,CAAC,CAAC;gBACtD,IAAI,SAAS,KAAK,SAAS,IAAI,SAAS,KAAK,SAAS,EAAE,CAAC;oBACvD,IAAI,CAAC,UAAU,CAAC,QAAQ,CAAC,IAAI,CAAC,QAAQ,EAAE,SAAS,EAAE,SAAS,EAAE,CAAC,EAAE,IAAI,CAAC,MAAM,IAAI,GAAG,CAAC,CAAC;gBACvF,CAAC;YACH,CAAC;QACH,CAAC;QAED,IAAI,CAAC,MAAM,CAAC,IAAI,CAAC,cAAc,EAAE,EAAE,KAAK,EAAE,KAAK,CAAC,MAAM,EAAE,KAAK,EAAE,KAAK,CAAC,MAAM,EAAE,CAAC,CAAC;IACjF,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,cAAc,CAClB,SAAiB,EACjB,OAAe,EACf,WAAqC;QAErC,IAAI,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC;YACtB,MAAM,IAAI,KAAK,CAAC,4BAA4B,CAAC,CAAC;QAChD,CAAC;QAED,MAAM,SAAS,GAAG,WAAW,CAAC,GAAG,EAAE,CAAC;QAEpC,IAAI,IAAI,CAAC,UAAU,IAAI,IAAI,CAAC,QAAQ,EAAE,CAAC;YACrC,MAAM,QAAQ,GAAG,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,SAAS,CAAC,CAAC;YACnD,MAAM,MAAM,GAAG,IAAI,CAAC,aAAa,CAAC,GAAG,CAAC,OAAO,CAAC,CAAC;YAE/C,IAAI,QAAQ,KAAK,SAAS,IAAI,MAAM,KAAK,SAAS,EAAE,CAAC;gBACnD,MAAM,OAAO,GAAI,WAAW,EAAE,OAAkB,IAAI,EAAE,CAAC;gBACvD,MAAM,WAAW,GAAG,IAAI,CAAC,UAAU,CAAC,YAAY,CAAC,IAAI,CAAC,QAAQ,EAAE,QAAQ,EAAE,MAAM,EAAE,OAAO,CAAC,CAAC;gBAE3F,MAAM,IAAI,GAAG,KAAK,CAAC,IAAI,CAAC,WAAW,CAAC;qBACjC,GAAG,CAAC,GAAG,CAAC,EAAE,CAAC,IAAI,CAAC,gBAAgB,CAAC,GAAG,CAAC,CAAC;qBACtC,MAAM,CAAC,CAAC,EAAE,EAAgB,EAAE,CAAC,EAAE,KAAK,SAAS,CAAC,CAAC;gBAElD,OAAO;oBACL,IAAI;oBACJ,UAAU,EAAE,IAAI;oBAChB,gBAAgB,EAAE,EAAE;oBACpB,SAAS,EAAE,GAAG;iBACf,CAAC;YACJ,CAAC;QACH,CAAC;QAED,6BAA6B;QAC7B,MAAM,IAAI,GAAG,IAAI,CAAC,OAAO,CAAC,SAAS,EAAE,OAAO,EAAE,WAAW,CAAC,CAAC;QAC3D,MAAM,QAAQ,GAAG,WAAW,CAAC,GAAG,EAAE,GAAG,SAAS,CAAC;QAE/C,IAAI,CAAC,MAAM,CAAC,KAAK,CAAC,mBAAmB,EAAE,EAAE,SAAS,EAAE,OAAO,EAAE,UAAU,EAAE,IAAI,CAAC,MAAM,EAAE,UAAU,EAAE,QAAQ,EAAE,CAAC,CAAC;QAE9G,OAAO;YACL,IAAI;YACJ,UAAU,EAAE,IAAI,CAAC,MAAM,GAAG,CAAC,CAAC,CAAC,CAAC,IAAI,CAAC,CAAC,CAAC,CAAC;YACtC,gBAAgB,EAAE,EAAE;YACpB,SAAS,EAAE,IAAI,CAAC,iBAAiB,CAAC,IAAI,CAAC;SACxC,CAAC;IACJ,CAAC;IAED;;OAEG;IACH,KAAK,CAAC,mBAAmB,CAAC,OAAiB;QACzC,IAAI,CAAC,IAAI,CAAC,WAAW,EAAE,CAAC;YACtB,MAAM,IAAI,KAAK,CAAC,4BAA4B,CAAC,CAAC;QAChD,CAAC;QAED,qDAAqD;QACrD,MAAM,gBAAgB,GAAG,IAAI,CAAC,oBAAoB,CAAC,iBAAiB,CAAC,OAAO,CAAC,CAAC;QAE9E,MAAM,YAAY,GAAG,gBAAgB,CAAC,GAAG,CAAC,EAAE,CAAC,EAAE,CAAC,CAAC;YAC/C,KAAK,EAAE,CAAC,EAAE,CAAC,KAAK,EAAE,EAAE,CAAC,KAAK,CAAC;YAC3B,IAAI,EAAE,WAAW;YACjB,QAAQ,EAAE,IAAI,CAAC,kBAAkB,CAAC,EAAE,CAAC,QAAQ,CAAC;YAC9C,SAAS,EAAE,eAAe;SAC3B,CAAC,CAAC,CAAC;QAEJ,MAAM,WAAW,GAAG,gBAAgB;aACjC,MAAM,CAAC,EAAE,CAAC,EAAE,CAAC,EAAE,CAAC,QAAQ,KAAK,OAAO,IAAI,EAAE,CAAC,QAAQ,KAAK,iBAAiB,CAAC;aAC1E,GAAG,CAAC,EAAE,CAAC,EAAE,CAAC,GAAG,EAAE,CAAC,KAAK,MAAM,EAAE,CAAC,KAAK,KAAK,EAAE,CAAC,WAAW,EAAE,CAAC,CAAC;QAE7D,MAAM,eAAe,GAAG,gBAAgB,CAAC,GAAG,CAAC,EAAE,CAAC,EAAE,CAAC,EAAE,CAAC,UAAU,IAAI,iBAAiB,CAAC,CAAC;QAEvF,OAAO;YACL,YAAY;YACZ,WAAW;YACX,eAAe,EAAE,CAAC,GAAG,IAAI,GAAG,CAAC,eAAe,CAAC,CAAC;SAC/C,CAAC;IACJ,CAAC;IAED;;OAEG;IACH,kBAAkB,CAAC,SAAiB;QAClC,OAAO,IAAI,CAAC,oBAAoB,CAAC,WAAW,CAAC,SAAS,CAAC,CAAC;IAC1D,CAAC;IAED;;OAEG;IACH,qBAAqB,CAAC,WAAqB,EAAE,iBAAyB,KAAK;QACzE,OAAO,IAAI,CAAC,oBAAoB,CAAC,iBAAiB,CAAC,WAAW,EAAE,cAAc,CAAC,CAAC;IAClF,CAAC;IAED;;OAEG;IACH,OAAO;QACL,IAAI,IAAI,CAAC,UAAU,IAAI,IAAI,CAAC,QAAQ,EAAE,CAAC;YACrC,IAAI,CAAC,UAAU,CAAC,UAAU,CAAC,IAAI,CAAC,QAAQ,CAAC,CAAC;QAC5C,CAAC;QACD,IAAI,CAAC,KAAK,CAAC,KAAK,EAAE,CAAC;QACnB,IAAI,CAAC,KAAK,GAAG,EAAE,CAAC;QAChB,IAAI,CAAC,aAAa,CAAC,KAAK,EAAE,CAAC;QAC3B,IAAI,CAAC,WAAW,GAAG,KAAK,CAAC;IAC3B,CAAC;IAED,kBAAkB;IAEV,KAAK,CAAC,eAAe;QAC3B,IAAI,CAAC;YACH,+DAA+D;YAC/D,MAAM,MAAM,GAAG,MAAM,MAAM,CAAC,yBAAyB,CAAC,mBAA6B,CAAyB,CAAC;YAC7G,OAAO,MAAM,CAAC,OAAO,IAAI,IAAI,CAAC;QAChC,CAAC;QAAC,MAAM,CAAC;YACP,OAAO,IAAI,CAAC;QACd,CAAC;IACH,CAAC;IAEO,KAAK,CAAC,cAAc,CAAC,QAAgB;QAC3C,MAAM,MAAM,GAAG,MAAM,MAAM,CAAC,QAAQ,CAAC,CAAC;QACtC,MAAM,MAAM,CAAC,OAAO,EAAE,CAAC;QACvB,OAAO,MAAuB,CAAC;IACjC,CAAC;IAEO,gBAAgB,CAAC,KAAa;QACpC,KAAK,MAAM,CAAC,EAAE,EAAE,GAAG,CAAC,IAAI,IAAI,CAAC,aAAa,EAAE,CAAC;YAC3C,IAAI,GAAG,KAAK,KAAK;gBAAE,OAAO,EAAE,CAAC;QAC/B,CAAC;QACD,OAAO,SAAS,CAAC;IACnB,CAAC;IAEO,OAAO,CAAC,KAAa,EAAE,GAAW,EAAE,WAAqC;QAC/E,MAAM,OAAO,GAAG,IAAI,GAAG,EAAU,CAAC;QAClC,MAAM,KAAK,GAA4C,CAAC,EAAE,IAAI,EAAE,KAAK,EAAE,IAAI,EAAE,CAAC,KAAK,CAAC,EAAE,CAAC,CAAC;QACxF,MAAM,YAAY,GAAG,IAAI,GAAG,CAAE,WAAW,EAAE,YAAyB,IAAI,EAAE,CAAC,CAAC;QAC5E,MAAM,OAAO,GAAI,WAAW,EAAE,OAAkB,IAAI,EAAE,CAAC;QAEvD,OAAO,KAAK,CAAC,MAAM,GAAG,CAAC,EAAE,CAAC;YACxB,MAAM,OAAO,GAAG,KAAK,CAAC,KAAK,EAAG,CAAC;YAE/B,IAAI,OAAO,CAAC,IAAI,KAAK,GAAG,EAAE,CAAC;gBACzB,OAAO,OAAO,CAAC,IAAI,CAAC;YACtB,CAAC;YAED,IAAI,OAAO,CAAC,IAAI,CAAC,MAAM,GAAG,OAAO;gBAAE,SAAS;YAC5C,IAAI,OAAO,CAAC,GAAG,CAAC,OAAO,CAAC,IAAI,CAAC;gBAAE,SAAS;YAExC,OAAO,CAAC,GAAG,CAAC,OAAO,CAAC,IAAI,CAAC,CAAC;YAE1B,sBAAsB;YACtB,KAAK,MAAM,IAAI,IAAI,IAAI,CAAC,KAAK,EAAE,CAAC;gBAC9B,IAAI,QAAQ,GAAkB,IAAI,CAAC;gBACnC,IAAI,IAAI,CAAC,MAAM,KAAK,OAAO,CAAC,IAAI;oBAAE,QAAQ,GAAG,IAAI,CAAC,MAAM,CAAC;gBACzD,IAAI,IAAI,CAAC,MAAM,KAAK,OAAO,CAAC,IAAI;oBAAE,QAAQ,GAAG,IAAI,CAAC,MAAM,CAAC;gBAEzD,IAAI,QAAQ,IAAI,CAAC,OAAO,CAAC,GAAG,CAAC,QAAQ,CAAC,IAAI,CAAC,YAAY,CAAC,GAAG,CAAC,QAAQ,CAAC,EAAE,CAAC;oBACtE,KAAK,CAAC,IAAI,CAAC,EAAE,IAAI,EAAE,QAAQ,EAAE,IAAI,EAAE,CAAC,GAAG,OAAO,CAAC,IAAI,EAAE,QAAQ,CAAC,EAAE,CAAC,CAAC;gBACpE,CAAC;YACH,CAAC;QACH,CAAC;QAED,OAAO,EAAE,CAAC;IACZ,CAAC;IAEO,iBAAiB,CAAC,IAAc;QACtC,IAAI,IAAI,CAAC,MAAM,KAAK,CAAC;YAAE,OAAO,GAAG,CAAC;QAElC,IAAI,IAAI,GAAG,CAAC,CAAC;QACb,KAAK,IAAI,CAAC,GAAG,CAAC,EAAE,CAAC,GAAG,IAAI,CAAC,MAAM,GAAG,CAAC,EAAE,CAAC,EAAE,EAAE,CAAC;YACzC,MAAM,IAAI,GAAG,IAAI,CAAC,KAAK,CAAC,IAAI,CAC1B,CAAC,CAAC,EAAE,CAAC,CAAC,CAAC,CAAC,MAAM,KAAK,IAAI,CAAC,CAAC,CAAC,IAAI,CAAC,CAAC,MAAM,KAAK,IAAI,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC;gBAClD,CAAC,CAAC,CAAC,MAAM,KAAK,IAAI,CAAC,CAAC,CAAC,IAAI,CAAC,CAAC,MAAM,KAAK,IAAI,CAAC,CAAC,GAAG,CAAC,CAAC,CAAC,CACxD,CAAC;YACF,IAAI,IAAI,IAAI,IAAI,CAAC,MAAM,KAAK,SAAS,EAAE,CAAC;gBACtC,IAAI,IAAI,CAAC,GAAG,IAAI,CAAC,MAAM,CAAC;YAC1B,CAAC;QACH,CAAC;QAED,OAAO,IAAI,CAAC,GAAG,CAAC,IAAI,GAAG,IAAI,CAAC,MAAM,EAAE,GAAG,CAAC,CAAC;IAC3C,CAAC;IAEO,kBAAkB,CAAC,QAA6B;QACtD,QAAQ,QAAQ,EAAE,CAAC;YACjB,KAAK,iBAAiB,CAAC,CAAC,OAAO,GAAG,CAAC;YACnC,KAAK,OAAO,CAAC,CAAC,OAAO,GAAG,CAAC;YACzB,KAAK,UAAU,CAAC,CAAC,OAAO,GAAG,CAAC;YAC5B,KAAK,OAAO,CAAC,CAAC,OAAO,GAAG,CAAC;YACzB,OAAO,CAAC,CAAC,OAAO,GAAG,CAAC;QACtB,CAAC;IACH,CAAC;CACF;AAED;;GAEG;AACH,MAAM,UAAU,eAAe,CAAC,MAA2B,EAAE,MAAe;IAC1E,OAAO,IAAI,mBAAmB,CAAC,MAAM,EAAE,MAAM,CAAC,CAAC;AACjD,CAAC;AAED,eAAe,mBAAmB,CAAC"}

package/dist/bridges/hnsw-bridge.d.ts

@@ -0,0 +1,98 @@
+/**
+ * HNSW Bridge - Healthcare Clinical Plugin
+ *
+ * Provides HNSW (Hierarchical Navigable Small World) vector search
+ * for patient similarity matching. Integrates with micro-hnsw-wasm
+ * for 150x faster similarity search.
+ *
+ * HIPAA Compliance:
+ * - All patient data processed locally in WASM sandbox
+ * - No PHI transmitted externally
+ * - Embeddings use differential privacy
+ */
+import type { HNSWBridge, HNSWConfig, PatientFeatures, SimilarPatient, Logger } from '../types.js';
+/**
+ * Patient embedding generator
+ * Converts clinical features to dense vector representations
+ */
+export declare class PatientEmbeddingGenerator {
+    private readonly dimensions;
+    constructor(dimensions?: number);
+    /**
+     * Generate embedding for patient features
+     * Uses a simplified bag-of-features approach
+     * In production, use ClinicalBERT or similar
+     */
+    generateEmbedding(features: PatientFeatures): Float32Array;
+    /**
+     * Calculate cosine similarity between two embeddings
+     */
+    cosineSimilarity(a: Float32Array, b: Float32Array): number;
+    private hashCode;
+    private getIndicesFromHash;
+    private normalizeLabValue;
+    private normalizeVitalValue;
+    private l2Normalize;
+}
+/**
+ * Healthcare HNSW Bridge implementation
+ * Wraps micro-hnsw-wasm for patient similarity search
+ */
+export declare class HealthcareHNSWBridge implements HNSWBridge {
+    private wasmModule;
+    private indexPtr;
+    private config;
+    private logger;
+    private idToIndex;
+    private indexToId;
+    private metadata;
+    private nextIndex;
+    private embeddingGenerator;
+    initialized: boolean;
+    constructor(config?: Partial<HNSWConfig>, logger?: Logger);
+    /**
+     * Initialize the HNSW index
+     */
+    initialize(config?: HNSWConfig): Promise<void>;
+    /**
+     * Add a patient vector to the index
+     */
+    addVector(id: string, vector: Float32Array, metadata?: Record<string, unknown>): Promise<void>;
+    /**
+     * Search for similar patients
+     */
+    search(query: Float32Array, topK: number, filter?: Record<string, unknown>): Promise<Array<{
+        id: string;
+        distance: number;
+    }>>;
+    /**
+     * Delete a patient vector from the index
+     */
+    delete(id: string): Promise<boolean>;
+    /**
+     * Get the number of vectors in the index
+     */
+    count(): Promise<number>;
+    /**
+     * Search for similar patients by clinical features
+     */
+    searchByFeatures(features: PatientFeatures, topK?: number, cohortFilter?: string): Promise<SimilarPatient[]>;
+    /**
+     * Add a patient by clinical features
+     */
+    addPatient(patientId: string, features: PatientFeatures, metadata?: Record<string, unknown>): Promise<void>;
+    /**
+     * Cleanup resources
+     */
+    destroy(): void;
+    private resolveWasmPath;
+    private loadWasmModule;
+    private bruteForceSearch;
+    private matchesFilter;
+}
+/**
+ * Create a new HNSW bridge instance
+ */
+export declare function createHNSWBridge(config?: Partial<HNSWConfig>, logger?: Logger): HealthcareHNSWBridge;
+export default HealthcareHNSWBridge;
+//# sourceMappingURL=hnsw-bridge.d.ts.map

package/dist/bridges/hnsw-bridge.d.ts.map

@@ -0,0 +1 @@
+{"version":3,"file":"hnsw-bridge.d.ts","sourceRoot":"","sources":["../../src/bridges/hnsw-bridge.ts"],"names":[],"mappings":"AAAA;;;;;;;;;;;GAWG;AAEH,OAAO,KAAK,EACV,UAAU,EACV,UAAU,EACV,eAAe,EACf,cAAc,EACd,MAAM,EACP,MAAM,aAAa,CAAC;AAyBrB;;;GAGG;AACH,qBAAa,yBAAyB;IACpC,OAAO,CAAC,QAAQ,CAAC,UAAU,CAAS;gBAExB,UAAU,GAAE,MAAY;IAIpC;;;;OAIG;IACH,iBAAiB,CAAC,QAAQ,EAAE,eAAe,GAAG,YAAY;IAuD1D;;OAEG;IACH,gBAAgB,CAAC,CAAC,EAAE,YAAY,EAAE,CAAC,EAAE,YAAY,GAAG,MAAM;IAiB1D,OAAO,CAAC,QAAQ;IAUhB,OAAO,CAAC,kBAAkB;IAQ1B,OAAO,CAAC,iBAAiB;IAkBzB,OAAO,CAAC,mBAAmB;IAiB3B,OAAO,CAAC,WAAW;CAYpB;AAED;;;GAGG;AACH,qBAAa,oBAAqB,YAAW,UAAU;IACrD,OAAO,CAAC,UAAU,CAA+B;IACjD,OAAO,CAAC,QAAQ,CAAa;IAC7B,OAAO,CAAC,MAAM,CAAa;IAC3B,OAAO,CAAC,MAAM,CAAS;IACvB,OAAO,CAAC,SAAS,CAAkC;IACnD,OAAO,CAAC,SAAS,CAAkC;IACnD,OAAO,CAAC,QAAQ,CAAmD;IACnE,OAAO,CAAC,SAAS,CAAK;IACtB,OAAO,CAAC,kBAAkB,CAA4B;IAE/C,WAAW,UAAS;gBAEf,MAAM,CAAC,EAAE,OAAO,CAAC,UAAU,CAAC,EAAE,MAAM,CAAC,EAAE,MAAM;IAYzD;;OAEG;IACG,UAAU,CAAC,MAAM,CAAC,EAAE,UAAU,GAAG,OAAO,CAAC,IAAI,CAAC;IAiCpD;;OAEG;IACG,SAAS,CACb,EAAE,EAAE,MAAM,EACV,MAAM,EAAE,YAAY,EACpB,QAAQ,CAAC,EAAE,MAAM,CAAC,MAAM,EAAE,OAAO,CAAC,GACjC,OAAO,CAAC,IAAI,CAAC;IAuBhB;;OAEG;IACG,MAAM,CACV,KAAK,EAAE,YAAY,EACnB,IAAI,EAAE,MAAM,EACZ,MAAM,CAAC,EAAE,MAAM,CAAC,MAAM,EAAE,OAAO,CAAC,GAC/B,OAAO,CAAC,KAAK,CAAC;QAAE,EAAE,EAAE,MAAM,CAAC;QAAC,QAAQ,EAAE,MAAM,CAAA;KAAE,CAAC,CAAC;IA0CnD;;OAEG;IACG,MAAM,CAAC,EAAE,EAAE,MAAM,GAAG,OAAO,CAAC,OAAO,CAAC;IAgB1C;;OAEG;IACG,KAAK,IAAI,OAAO,CAAC,MAAM,CAAC;IAO9B;;OAEG;IACG,gBAAgB,CACpB,QAAQ,EAAE,eAAe,EACzB,IAAI,GAAE,MAAU,EAChB,YAAY,CAAC,EAAE,MAAM,GACpB,OAAO,CAAC,cAAc,EAAE,CAAC;IAiB5B;;OAEG;IACG,UAAU,CACd,SAAS,EAAE,MAAM,EACjB,QAAQ,EAAE,eAAe,EACzB,QAAQ,CAAC,EAAE,MAAM,CAAC,MAAM,EAAE,OAAO,CAAC,GACjC,OAAO,CAAC,IAAI,CAAC;IAShB;;OAEG;IACH,OAAO,IAAI,IAAI;YAYD,eAAe;YAUf,cAAc;IAO5B,OAAO,CAAC,gBAAgB;IAsBxB,OAAO,CAAC,aAAa;CAStB;AAED;;GAEG;AACH,wBAAgB,gBAAgB,CAAC,MAAM,CAAC,EAAE,OAAO,CAAC,UAAU,CAAC,EAAE,MAAM,CAAC,EAAE,MAAM,GAAG,oBAAoB,CAEpG;AAED,eAAe,oBAAoB,CAAC"}