viral_seq 1.8.1.1 → 1.9.0
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- checksums.yaml +4 -4
- data/Gemfile.lock +1 -1
- data/README.md +6 -0
- data/bin/tcs +7 -1
- data/bin/tcs_sdrm +87 -131
- data/lib/viral_seq/drm_region_config.rb +83 -0
- data/lib/viral_seq/drm_version.rb +120 -0
- data/lib/viral_seq/hivdr.rb +206 -2
- data/lib/viral_seq/sdrm.rb +34 -99
- data/lib/viral_seq/sequence.rb +26 -1
- data/lib/viral_seq/tcs_core.rb +1 -1
- data/lib/viral_seq/tcs_dr.rb +87 -5
- data/lib/viral_seq/util/drm_list.json +684 -0
- data/lib/viral_seq/util/drm_versions_config.json +114 -0
- data/lib/viral_seq/version.rb +2 -2
- data/lib/viral_seq.rb +3 -0
- metadata +7 -3
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{
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"HCV_NS5A": [
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{
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"position": 28,
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"wild-type": "M",
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"mutations": [
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{
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"position": 30,
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"wild-type": "L",
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"mutations": [
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"H",
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"K",
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"position": 31,
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"wild-type": "L",
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"mutations": [
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"M",
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"V",
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"position": 32,
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"wild-type": "P",
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"mutations": [
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"L"
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"position": 44,
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"wild-type": "K",
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"mutations": [
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{
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"position": 58,
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"wild-type": "H",
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"mutations": [
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"D",
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"P",
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{
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"position": 64,
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"wild-type": "T",
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"mutations": [
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"A",
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"position": 77,
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"wild-type": "P",
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"mutations": [
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"position": 78,
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"wild-type": "R",
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"mutations": [
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"K"
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"position": 79,
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"wild-type": "T",
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"mutations": [
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"position": 83,
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"wild-type": "T",
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"mutations": [
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{
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"position": 85,
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"wild-type": "S",
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"mutations": [
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"N",
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"H",
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"position": 92,
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"wild-type": "A",
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"mutations": [
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"position": 93,
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"wild-type": "Y",
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"mutations": [
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"C",
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{
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"position": 107,
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"wild-type": "K",
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"mutations": [
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"position": 121,
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"wild-type": "I",
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"mutations": [
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"position": 135,
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"wild-type": "T",
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"mutations": [
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"NRTI": [
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"position": 41,
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"wild-type": "M",
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"mutations": [
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"L"
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{
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"position": 65,
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"wild-type": "K",
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"mutations": [
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"position": 67,
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"wild-type": "D",
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"mutations": [
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"N",
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"position": 69,
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"wild-type": "T",
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"mutations": [
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"position": 70,
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"wild-type": "K",
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"mutations": [
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"position": 74,
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"wild-type": "L",
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"mutations": [
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"position": 75,
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"wild-type": "V",
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"mutations": [
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"position": 77,
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"wild-type": "F",
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"mutations": [
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"position": 115,
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"wild-type": "Y",
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"mutations": [
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"position": 116,
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"wild-type": "F",
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"mutations": [
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"position": 151,
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"wild-type": "Q",
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"mutations": [
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"position": 184,
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"wild-type": "M",
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"mutations": [
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{
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"position": 210,
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"wild-type": "L",
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"mutations": [
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{
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"position": 215,
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"wild-type": "T",
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"mutations": [
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"Y",
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"I",
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{
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"position": 219,
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"wild-type": "K",
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"mutations": [
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"Q",
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"N",
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"NNRTI": [
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{
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"position": 98,
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"wild-type": "A",
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"mutations": [
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{
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"position": 100,
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"wild-type": "L",
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"mutations": [
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{
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"position": 101,
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"wild-type": "K",
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"mutations": [
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"E",
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{
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"position": 103,
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"wild-type": "K",
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"mutations": [
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{
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"position": 106,
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"wild-type": "V",
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"mutations": [
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"M",
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{
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"position": 138,
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"wild-type": "E",
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"mutations": [
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"A",
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"K",
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{
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"position": 179,
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"wild-type": "V",
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"mutations": [
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"F",
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"D"
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{
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"position": 181,
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"wild-type": "Y",
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"mutations": [
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"C",
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"I",
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"V"
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{
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"position": 188,
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"wild-type": "Y",
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"mutations": [
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"L",
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"H",
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},
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{
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"position": 190,
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"wild-type": "G",
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"mutations": [
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"A",
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{
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"position": 225,
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"wild-type": "P",
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"mutations": [
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"H"
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},
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{
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"position": 230,
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"wild-type": "M",
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"mutations": [
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"L"
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}
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],
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"PI": [
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{
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"position": 23,
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"wild-type": "L",
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"mutations": [
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"I"
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},
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{
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"position": 24,
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"wild-type": "L",
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"mutations": [
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"I"
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},
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{
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"position": 30,
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"wild-type": "D",
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"mutations": [
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"N"
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},
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{
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"position": 32,
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"wild-type": "V",
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"mutations": [
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"I"
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},
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{
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"position": 46,
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"wild-type": "M",
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"mutations": [
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"I",
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"L"
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{
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"position": 47,
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"wild-type": "I",
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"mutations": [
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"V",
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{
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"position": 48,
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"wild-type": "G",
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"mutations": [
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"V",
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"M"
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{
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"position": 50,
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"wild-type": "I",
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"mutations": [
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"V",
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{
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"position": 53,
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"wild-type": "F",
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"mutations": [
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{
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"position": 54,
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"wild-type": "I",
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"mutations": [
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"V",
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"L",
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"M",
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{
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"position": 73,
|
452
|
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|
453
|
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|
454
|
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"S",
|
455
|
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"T",
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456
|
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"C",
|
457
|
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"A"
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458
|
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459
|
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},
|
460
|
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{
|
461
|
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|
462
|
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|
463
|
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|
464
|
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"V"
|
465
|
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|
466
|
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},
|
467
|
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{
|
468
|
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|
469
|
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|
470
|
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|
471
|
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"A",
|
472
|
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"T",
|
473
|
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"S",
|
474
|
+
"F",
|
475
|
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"L",
|
476
|
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"C",
|
477
|
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"M"
|
478
|
+
]
|
479
|
+
},
|
480
|
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{
|
481
|
+
"position": 83,
|
482
|
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|
483
|
+
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|
484
|
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"D"
|
485
|
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]
|
486
|
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},
|
487
|
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{
|
488
|
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|
489
|
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|
490
|
+
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|
491
|
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"V",
|
492
|
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"A",
|
493
|
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"C"
|
494
|
+
]
|
495
|
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},
|
496
|
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{
|
497
|
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|
498
|
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|
499
|
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|
500
|
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"D",
|
501
|
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"S"
|
502
|
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]
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503
|
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},
|
504
|
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{
|
505
|
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"position": 90,
|
506
|
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|
507
|
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|
508
|
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"M"
|
509
|
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]
|
510
|
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}
|
511
|
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],
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512
|
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"INSTI": [
|
513
|
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{
|
514
|
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|
515
|
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|
516
|
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517
|
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"A",
|
518
|
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"I",
|
519
|
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"K"
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520
|
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]
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521
|
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},
|
522
|
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{
|
523
|
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|
524
|
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|
525
|
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|
526
|
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"M"
|
527
|
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]
|
528
|
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},
|
529
|
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{
|
530
|
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|
531
|
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|
532
|
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|
533
|
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"Q"
|
534
|
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]
|
535
|
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},
|
536
|
+
{
|
537
|
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|
538
|
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|
539
|
+
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|
540
|
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"K"
|
541
|
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]
|
542
|
+
},
|
543
|
+
{
|
544
|
+
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|
545
|
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|
546
|
+
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|
547
|
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"A"
|
548
|
+
]
|
549
|
+
},
|
550
|
+
{
|
551
|
+
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|
552
|
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"wild-type": "F",
|
553
|
+
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|
554
|
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"Y"
|
555
|
+
]
|
556
|
+
},
|
557
|
+
{
|
558
|
+
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|
559
|
+
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|
560
|
+
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|
561
|
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"A",
|
562
|
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"S",
|
563
|
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"C"
|
564
|
+
]
|
565
|
+
},
|
566
|
+
{
|
567
|
+
"position": 143,
|
568
|
+
"wild-type": "Y",
|
569
|
+
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|
570
|
+
"C",
|
571
|
+
"H",
|
572
|
+
"R"
|
573
|
+
]
|
574
|
+
},
|
575
|
+
{
|
576
|
+
"position": 147,
|
577
|
+
"wild-type": "S",
|
578
|
+
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|
579
|
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"G"
|
580
|
+
]
|
581
|
+
},
|
582
|
+
{
|
583
|
+
"position": 148,
|
584
|
+
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|
585
|
+
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|
586
|
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"H",
|
587
|
+
"K",
|
588
|
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"R"
|
589
|
+
]
|
590
|
+
},
|
591
|
+
{
|
592
|
+
"position": 263,
|
593
|
+
"wild-type": "R",
|
594
|
+
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|
595
|
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"K"
|
596
|
+
]
|
597
|
+
},
|
598
|
+
{
|
599
|
+
"position": 155,
|
600
|
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"wild-type": [
|
601
|
+
"N",
|
602
|
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[
|
603
|
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"S",
|
604
|
+
"H"
|
605
|
+
]
|
606
|
+
],
|
607
|
+
"mutations": [
|
608
|
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"R",
|
609
|
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[
|
610
|
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"K"
|
611
|
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]
|
612
|
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]
|
613
|
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}
|
614
|
+
],
|
615
|
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"CAI": [
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616
|
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{
|
617
|
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|
618
|
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"wild-type": "L",
|
619
|
+
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|
620
|
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"I"
|
621
|
+
]
|
622
|
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},
|
623
|
+
{
|
624
|
+
"position": 57,
|
625
|
+
"wild-type": "N",
|
626
|
+
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|
627
|
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"S"
|
628
|
+
]
|
629
|
+
},
|
630
|
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{
|
631
|
+
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|
632
|
+
"wild-type": "M",
|
633
|
+
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|
634
|
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"I"
|
635
|
+
]
|
636
|
+
},
|
637
|
+
{
|
638
|
+
"position": 67,
|
639
|
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|
640
|
+
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|
641
|
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"H",
|
642
|
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"Y",
|
643
|
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"N",
|
644
|
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"K"
|
645
|
+
]
|
646
|
+
},
|
647
|
+
{
|
648
|
+
"position": 70,
|
649
|
+
"wild-type": "K",
|
650
|
+
"mutations": [
|
651
|
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"N",
|
652
|
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"H",
|
653
|
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"R",
|
654
|
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"S"
|
655
|
+
]
|
656
|
+
},
|
657
|
+
{
|
658
|
+
"position": 74,
|
659
|
+
"wild-type": "N",
|
660
|
+
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|
661
|
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"D",
|
662
|
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"S"
|
663
|
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]
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664
|
+
},
|
665
|
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{
|
666
|
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"position": 105,
|
667
|
+
"wild-type": "A",
|
668
|
+
"mutations": [
|
669
|
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"T",
|
670
|
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"S",
|
671
|
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"E"
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672
|
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]
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673
|
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},
|
674
|
+
{
|
675
|
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"position": 107,
|
676
|
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"wild-type": "T",
|
677
|
+
"mutations": [
|
678
|
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"N",
|
679
|
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"S",
|
680
|
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"A"
|
681
|
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]
|
682
|
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}
|
683
|
+
]
|
684
|
+
}
|