RubyGems - simple_bioc - Versions diffs - 0.0.16 → 0.0.17 - Mend

simple_bioc 0.0.16 → 0.0.17

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.

Files changed (16) hide show

checksums.yaml +4 -4
data/lib/simple_bioc/annotation.rb +1 -1
data/lib/simple_bioc/bioc_reader.rb +6 -2
data/lib/simple_bioc/bioc_writer.rb +11 -10
data/lib/simple_bioc/document.rb +5 -5
data/lib/simple_bioc/location_adjuster.rb +3 -1
data/lib/simple_bioc/node.rb +2 -2
data/lib/simple_bioc/node_base.rb +1 -1
data/lib/simple_bioc/passage.rb +5 -5
data/lib/simple_bioc/relation.rb +1 -1
data/lib/simple_bioc/sentence.rb +3 -3
data/lib/simple_bioc/version.rb +1 -1
data/xml/merge/output.xml +974 -974
data/xml/merge/output_10330397.xml +317 -317
data/xml/merge/output_10366597.xml +1 -1
metadata +2 -2

data/xml/merge/output_10330397.xml CHANGED Viewed

@@ -96,57 +96,57 @@
       </annotation>
       <annotation id="Team286_A14">
         <infon key="type">Gene</infon>
-        <location offset="727" length="4"/>
+        <location offset="728" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A15">
         <infon key="type">Gene</infon>
-        <location offset="778" length="29"/>
+        <location offset="779" length="29"/>
         <text>plasma membrane proton-ATPase</text>
       </annotation>
       <annotation id="Team286_A16">
         <infon key="type">Gene</infon>
-        <location offset="810" length="5"/>
+        <location offset="811" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A17">
         <infon key="type">Gene</infon>
-        <location offset="979" length="5"/>
+        <location offset="980" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A18">
         <infon key="type">Gene</infon>
-        <location offset="1012" length="17"/>
+        <location offset="1013" length="17"/>
         <text>lst1Delta mutants</text>
       </annotation>
       <annotation id="Team286_A19">
         <infon key="type">Gene</infon>
-        <location offset="1110" length="15"/>
+        <location offset="1112" length="15"/>
         <text>Pma1p transport</text>
       </annotation>
       <annotation id="Team286_A20">
         <infon key="type">Gene</infon>
-        <location offset="1252" length="18"/>
+        <location offset="1254" length="18"/>
         <text>COPII coat subunit</text>
       </annotation>
       <annotation id="Team286_A21">
         <infon key="type">Gene</infon>
-        <location offset="1277" length="5"/>
+        <location offset="1279" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A22">
         <infon key="type">Gene</infon>
-        <location offset="1295" length="6"/>
+        <location offset="1297" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A23">
         <infon key="type">Gene</infon>
-        <location offset="1343" length="5"/>
+        <location offset="1345" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="TEAM_336_PPI0">
         <infon key="type">PPImention</infon>
-        <location offset="608" length="94"/>
+        <location offset="608" length="94" original_offset="0"/>
         <text>Like Sec24p, Lst1p is a peripheral ER membrane protein that binds to the COPII subunit Sec23p.</text>
       </annotation>
     </passage>
@@ -326,12 +326,12 @@
       </annotation>
       <annotation id="TEAM_336_PPI1">
         <infon key="type">PPImention</infon>
-        <location offset="3406" length="348"/>
+        <location offset="3406" length="348" original_offset="0"/>
         <text>Membrane-associated Sar1p, in turn, recruits the soluble Sec23p/Sec24p and Sec13p/Sec31p complexes (Matsuoka et al., 1998). Sec16p resides on the ER  membrane and binds to both the Sec23p/Sec24p and  Sec13p/Sec31p complexes, likely organizing their assembly  onto the membrane (Espenshade et al., 1995; Gimeno et al.,  1996; Shaywitz et al., 1997).</text>
       </annotation>
       <annotation id="TEAM_336_PPI2">
         <infon key="type">PPImention</infon>
-        <location offset="3963" length="291"/>
+        <location offset="3963" length="291" original_offset="0"/>
         <text>Association of a membrane-bound complex of Sar1p and  Sec23p/Sec24p with integral membrane proteins indicates  that cargo proteins may laterally partition into the vesicle  membrane by virtue of their affinity for the Sec23p/Sec24p  protein complex (Aridor et al., 1998; Kuehn et al., 1998).</text>
       </annotation>
     </passage>
@@ -356,7 +356,7 @@
       </annotation>
       <annotation id="Team286_A60">
         <infon key="type">Gene</infon>
-        <location offset="5068" length="10"/>
+        <location offset="5069" length="10"/>
         <text>COPII coat</text>
       </annotation>
     </passage>
@@ -401,62 +401,62 @@
       </annotation>
       <annotation id="Team286_A68">
         <infon key="type">Gene</infon>
-        <location offset="5564" length="4"/>
+        <location offset="5565" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A69">
         <infon key="type">Gene</infon>
-        <location offset="5718" length="4"/>
+        <location offset="5719" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A70">
         <infon key="type">Gene</infon>
-        <location offset="5789" length="4"/>
+        <location offset="5790" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A71">
         <infon key="type">Gene</infon>
-        <location offset="5822" length="13"/>
+        <location offset="5823" length="13"/>
         <text>COPII subunit</text>
       </annotation>
       <annotation id="Team286_A72">
         <infon key="type">Gene</infon>
-        <location offset="5837" length="6"/>
+        <location offset="5838" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A73">
         <infon key="type">Gene</infon>
-        <location offset="5854" length="5"/>
+        <location offset="5855" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A74">
         <infon key="type">Gene</infon>
-        <location offset="5943" length="6"/>
+        <location offset="5944" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A75">
         <infon key="type">Gene</infon>
-        <location offset="5955" length="9"/>
+        <location offset="5956" length="9"/>
         <text>LST1 gene</text>
       </annotation>
       <annotation id="Team286_A76">
         <infon key="type">Gene</infon>
-        <location offset="6024" length="17"/>
+        <location offset="6025" length="17"/>
         <text>lst1Delta mutants</text>
       </annotation>
       <annotation id="Team286_A77">
         <infon key="type">Gene</infon>
-        <location offset="6056" length="4"/>
+        <location offset="6057" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A78">
         <infon key="type">Gene</infon>
-        <location offset="6101" length="5"/>
+        <location offset="6102" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A79">
         <infon key="type">Gene</infon>
-        <location offset="6246" length="5"/>
+        <location offset="6247" length="5"/>
         <text>Pma1p</text>
       </annotation>
     </passage>
@@ -711,42 +711,42 @@
       </annotation>
       <annotation id="Team286_A126">
         <infon key="type">Gene</infon>
-        <location offset="8575" length="11"/>
+        <location offset="8576" length="11"/>
         <text>HA epitopes</text>
       </annotation>
       <annotation id="Team286_A127">
         <infon key="type">Gene</infon>
-        <location offset="8604" length="7"/>
+        <location offset="8605" length="7"/>
         <text>pKR17HA</text>
       </annotation>
       <annotation id="Team286_A128">
         <infon key="type">Gene</infon>
-        <location offset="8613" length="7"/>
+        <location offset="8615" length="7"/>
         <text>pKR17HA</text>
       </annotation>
       <annotation id="Team286_A129">
         <infon key="type">Gene</infon>
-        <location offset="8642" length="6"/>
+        <location offset="8644" length="6"/>
         <text>CKY536</text>
       </annotation>
       <annotation id="Team286_A130">
         <infon key="type">Gene</infon>
-        <location offset="8657" length="6"/>
+        <location offset="8659" length="6"/>
         <text>CKY535</text>
       </annotation>
       <annotation id="Team286_A131">
         <infon key="type">Gene</infon>
-        <location offset="8665" length="14"/>
+        <location offset="8667" length="14"/>
         <text>MATa lst1Delta</text>
       </annotation>
       <annotation id="Team286_A132">
         <infon key="type">Gene</infon>
-        <location offset="8683" length="24"/>
+        <location offset="8685" length="24"/>
         <text>LEU2 leu2-3, 112 ura3-52</text>
       </annotation>
       <annotation id="Team286_A133">
         <infon key="type">Gene</infon>
-        <location offset="8709" length="7"/>
+        <location offset="8711" length="7"/>
         <text>pKR17HA</text>
       </annotation>
     </passage>
@@ -886,22 +886,22 @@
       </annotation>
       <annotation id="Team286_A158">
         <infon key="type">Gene</infon>
-        <location offset="9815" length="7"/>
+        <location offset="9816" length="7"/>
         <text>sec13-1</text>
       </annotation>
       <annotation id="Team286_A159">
         <infon key="type">Gene</infon>
-        <location offset="9954" length="4"/>
+        <location offset="9955" length="4"/>
         <text>pKR1</text>
       </annotation>
       <annotation id="Team286_A160">
         <infon key="type">Gene</infon>
-        <location offset="9994" length="6"/>
+        <location offset="9995" length="6"/>
         <text>pRS316</text>
       </annotation>
       <annotation id="Team286_A161">
         <infon key="type">Gene</infon>
-        <location offset="10018" length="7"/>
+        <location offset="10019" length="7"/>
         <text>sec13-1</text>
       </annotation>
     </passage>
@@ -1186,82 +1186,82 @@
       </annotation>
       <annotation id="Team286_A213">
         <infon key="type">Gene</infon>
-        <location offset="12374" length="4"/>
+        <location offset="12375" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A214">
         <infon key="type">Gene</infon>
-        <location offset="12437" length="8"/>
+        <location offset="12438" length="8"/>
         <text>Eco47III</text>
       </annotation>
       <annotation id="Team286_A215">
         <infon key="type">Gene</infon>
-        <location offset="12446" length="4"/>
+        <location offset="12447" length="4"/>
         <text>MscI</text>
       </annotation>
       <annotation id="Team286_A216">
         <infon key="type">Gene</infon>
-        <location offset="12465" length="5"/>
+        <location offset="12466" length="5"/>
         <text>pKR28</text>
       </annotation>
       <annotation id="Team286_A217">
         <infon key="type">Gene</infon>
-        <location offset="12483" length="10"/>
+        <location offset="12484" length="10"/>
         <text>pKR28Delta</text>
       </annotation>
       <annotation id="Team286_A218">
         <infon key="type">Gene</infon>
-        <location offset="12510" length="14"/>
+        <location offset="12511" length="14"/>
         <text>LEU2 construct</text>
       </annotation>
       <annotation id="Team286_A219">
         <infon key="type">Gene</infon>
-        <location offset="12541" length="10"/>
+        <location offset="12542" length="10"/>
         <text>pKR28Delta</text>
       </annotation>
       <annotation id="Team286_A220">
         <infon key="type">Gene</infon>
-        <location offset="12570" length="4"/>
+        <location offset="12571" length="4"/>
         <text>XhoI</text>
       </annotation>
       <annotation id="Team286_A221">
         <infon key="type">Gene</infon>
-        <location offset="12627" length="6"/>
+        <location offset="12628" length="6"/>
         <text>CKY348</text>
       </annotation>
       <annotation id="Team286_A222">
         <infon key="type">Gene</infon>
-        <location offset="12635" length="28"/>
+        <location offset="12636" length="28"/>
         <text>MATa/alpha leu2-3,112/leu2-3</text>
       </annotation>
       <annotation id="Team286_A223">
         <infon key="type">Gene</infon>
-        <location offset="12664" length="3"/>
+        <location offset="12665" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A224">
         <infon key="type">Gene</infon>
-        <location offset="12668" length="7"/>
+        <location offset="12669" length="7"/>
         <text>ura3-52</text>
       </annotation>
       <annotation id="Team286_A225">
         <infon key="type">Gene</infon>
-        <location offset="12676" length="7"/>
+        <location offset="12677" length="7"/>
         <text>ura3-52</text>
       </annotation>
       <annotation id="Team286_A226">
         <infon key="type">Gene</infon>
-        <location offset="12794" length="9"/>
+        <location offset="12795" length="9"/>
         <text>lst1Delta</text>
       </annotation>
       <annotation id="Team286_A227">
         <infon key="type">Gene</infon>
-        <location offset="12805" length="4"/>
+        <location offset="12806" length="4"/>
         <text>LEU2</text>
       </annotation>
       <annotation id="Team286_A228">
         <infon key="type">Gene</infon>
-        <location offset="12951" length="6"/>
+        <location offset="12952" length="6"/>
         <text>CKY542</text>
       </annotation>
     </passage>
@@ -1666,7 +1666,7 @@
       </annotation>
       <annotation id="TEAM_336_PPI3">
         <infon key="type">PPImention</infon>
-        <location offset="21609" length="26"/>
+        <location offset="21609" length="26" original_offset="0"/>
         <text>Binding of Lst1p to Sec23p</text>
       </annotation>
     </passage>
@@ -1766,32 +1766,32 @@
       </annotation>
       <annotation id="Team286_A310">
         <infon key="type">Gene</infon>
-        <location offset="22102" length="6"/>
+        <location offset="22103" length="6"/>
         <text>CKY473</text>
       </annotation>
       <annotation id="Team286_A311">
         <infon key="type">Gene</infon>
-        <location offset="22127" length="6"/>
+        <location offset="22128" length="6"/>
         <text>pRH254</text>
       </annotation>
       <annotation id="Team286_A312">
         <infon key="type">Gene</infon>
-        <location offset="22135" length="3"/>
+        <location offset="22136" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A313">
         <infon key="type">Gene</infon>
-        <location offset="22139" length="5"/>
+        <location offset="22140" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A314">
         <infon key="type">Gene</infon>
-        <location offset="22178" length="6"/>
+        <location offset="22179" length="6"/>
         <text>pPE123</text>
       </annotation>
       <annotation id="Team286_A315">
         <infon key="type">Gene</infon>
-        <location offset="22186" length="6"/>
+        <location offset="22187" length="6"/>
         <text>Sec23p</text>
       </annotation>
     </passage>
@@ -2186,182 +2186,182 @@
       </annotation>
       <annotation id="Team286_A384">
         <infon key="type">Gene</infon>
-        <location offset="27979" length="6"/>
+        <location offset="27980" length="6"/>
         <text>CKY426</text>
       </annotation>
       <annotation id="Team286_A385">
         <infon key="type">Gene</infon>
-        <location offset="28201" length="5"/>
+        <location offset="28202" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A386">
         <infon key="type">Gene</infon>
-        <location offset="28211" length="4"/>
+        <location offset="28212" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A387">
         <infon key="type">Gene</infon>
-        <location offset="28279" length="5"/>
+        <location offset="28280" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A388">
         <infon key="type">Gene</infon>
-        <location offset="28379" length="7"/>
+        <location offset="28380" length="7"/>
         <text>sec13-1</text>
       </annotation>
       <annotation id="Team286_A389">
         <infon key="type">Gene</infon>
-        <location offset="28516" length="6"/>
+        <location offset="28517" length="6"/>
         <text>p21-31</text>
       </annotation>
       <annotation id="Team286_A390">
         <infon key="type">Gene</infon>
-        <location offset="28527" length="5"/>
+        <location offset="28528" length="5"/>
         <text>p77-2</text>
       </annotation>
       <annotation id="Team286_A391">
         <infon key="type">Gene</infon>
-        <location offset="28610" length="5"/>
+        <location offset="28611" length="5"/>
         <text>p77-2</text>
       </annotation>
       <annotation id="Team286_A392">
         <infon key="type">Gene</infon>
-        <location offset="28693" length="4"/>
+        <location offset="28694" length="4"/>
         <text>XhoI</text>
       </annotation>
       <annotation id="Team286_A393">
         <infon key="type">Gene</infon>
-        <location offset="28753" length="5"/>
+        <location offset="28754" length="5"/>
         <text>pKR20</text>
       </annotation>
       <annotation id="Team286_A394">
         <infon key="type">Gene</infon>
-        <location offset="28790" length="5"/>
+        <location offset="28791" length="5"/>
         <text>pKR20</text>
       </annotation>
       <annotation id="Team286_A395">
         <infon key="type">Gene</infon>
-        <location offset="28829" length="4"/>
+        <location offset="28830" length="4"/>
         <text>HpaI</text>
       </annotation>
       <annotation id="Team286_A396">
         <infon key="type">Gene</infon>
-        <location offset="28856" length="6"/>
+        <location offset="28857" length="6"/>
         <text>CUY564</text>
       </annotation>
       <annotation id="Team286_A397">
         <infon key="type">Gene</infon>
-        <location offset="28864" length="29"/>
+        <location offset="28865" length="29"/>
         <text>MATalpha ade2 ade3 leu2  ura3</text>
       </annotation>
       <annotation id="Team286_A398">
         <infon key="type">Gene</infon>
-        <location offset="28936" length="21"/>
+        <location offset="28937" length="21"/>
         <text>lst1-1 mutant  CKY426</text>
       </annotation>
       <annotation id="Team286_A399">
         <infon key="type">Gene</infon>
-        <location offset="28959" length="4"/>
+        <location offset="28960" length="4"/>
         <text>MATa</text>
       </annotation>
       <annotation id="Team286_A400">
         <infon key="type">Gene</infon>
-        <location offset="28964" length="19"/>
+        <location offset="28965" length="19"/>
         <text>lst1-1 sec13-1 ade2</text>
       </annotation>
       <annotation id="Team286_A401">
         <infon key="type">Gene</infon>
-        <location offset="28984" length="14"/>
+        <location offset="28985" length="14"/>
         <text>ade3 leu2 ura3</text>
       </annotation>
       <annotation id="Team286_A402">
         <infon key="type">Gene</infon>
-        <location offset="29001" length="4"/>
+        <location offset="29002" length="4"/>
         <text>pKR4</text>
       </annotation>
       <annotation id="Team286_A403">
         <infon key="type">Gene</infon>
-        <location offset="29059" length="5"/>
+        <location offset="29060" length="5"/>
         <text>pKR20</text>
       </annotation>
       <annotation id="Team286_A404">
         <infon key="type">Gene</infon>
-        <location offset="29106" length="10"/>
+        <location offset="29107" length="10"/>
         <text>LST1 locus</text>
       </annotation>
       <annotation id="Team286_A405">
         <infon key="type">Gene</infon>
-        <location offset="29175" length="4"/>
+        <location offset="29176" length="4"/>
         <text>Ura+</text>
       </annotation>
       <annotation id="Team286_A406">
         <infon key="type">Gene</infon>
-        <location offset="29219" length="3"/>
+        <location offset="29220" length="3"/>
         <text>Ura</text>
       </annotation>
       <annotation id="Team286_A407">
         <infon key="type">Gene</infon>
-        <location offset="29231" length="5"/>
+        <location offset="29233" length="5"/>
         <text>p77-2</text>
       </annotation>
       <annotation id="Team286_A408">
         <infon key="type">Gene</infon>
-        <location offset="29249" length="9"/>
+        <location offset="29251" length="9"/>
         <text>LST1 gene</text>
       </annotation>
       <annotation id="Team286_A409">
         <infon key="type">Gene</infon>
-        <location offset="29299" length="6"/>
+        <location offset="29301" length="6"/>
         <text>p21-31</text>
       </annotation>
       <annotation id="Team286_A410">
         <infon key="type">Gene</infon>
-        <location offset="29378" length="5"/>
+        <location offset="29380" length="5"/>
         <text>EcoRI</text>
       </annotation>
       <annotation id="Team286_A411">
         <infon key="type">Gene</infon>
-        <location offset="29384" length="7"/>
+        <location offset="29386" length="7"/>
         <text>HindIII</text>
       </annotation>
       <annotation id="Team286_A412">
         <infon key="type">Gene</infon>
-        <location offset="29407" length="6"/>
+        <location offset="29409" length="6"/>
         <text>pRS306</text>
       </annotation>
       <annotation id="Team286_A413">
         <infon key="type">Gene</infon>
-        <location offset="29425" length="4"/>
+        <location offset="29427" length="4"/>
         <text>pKR7</text>
       </annotation>
       <annotation id="Team286_A414">
         <infon key="type">Gene</infon>
-        <location offset="29431" length="4"/>
+        <location offset="29433" length="4"/>
         <text>pKR7</text>
       </annotation>
       <annotation id="Team286_A415">
         <infon key="type">Gene</infon>
-        <location offset="29502" length="4"/>
+        <location offset="29504" length="4"/>
         <text>MscI</text>
       </annotation>
       <annotation id="Team286_A416">
         <infon key="type">Gene</infon>
-        <location offset="29543" length="6"/>
+        <location offset="29545" length="6"/>
         <text>lst1-1</text>
       </annotation>
       <annotation id="Team286_A417">
         <infon key="type">Gene</infon>
-        <location offset="29580" length="4"/>
+        <location offset="29582" length="4"/>
         <text>pKR7</text>
       </annotation>
       <annotation id="Team286_A418">
         <infon key="type">Gene</infon>
-        <location offset="29603" length="4"/>
+        <location offset="29605" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A419">
         <infon key="type">Gene</infon>
-        <location offset="29631" length="4"/>
+        <location offset="29633" length="4"/>
         <text>pKR7</text>
       </annotation>
     </passage>
@@ -2381,32 +2381,32 @@
       </annotation>
       <annotation id="Team286_A422">
         <infon key="type">Gene</infon>
-        <location offset="30102" length="4"/>
+        <location offset="30103" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A423">
         <infon key="type">Gene</infon>
-        <location offset="30140" length="5"/>
+        <location offset="30141" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A424">
         <infon key="type">Gene</infon>
-        <location offset="30147" length="7"/>
+        <location offset="30148" length="7"/>
         <text>YIL109C</text>
       </annotation>
       <annotation id="Team286_A425">
         <infon key="type">Gene</infon>
-        <location offset="30268" length="5"/>
+        <location offset="30269" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A426">
         <infon key="type">Gene</infon>
-        <location offset="30314" length="6"/>
+        <location offset="30315" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A427">
         <infon key="type">Gene</infon>
-        <location offset="30342" length="18"/>
+        <location offset="30343" length="18"/>
         <text>COPII vesicle coat</text>
       </annotation>
     </passage>
@@ -2766,87 +2766,87 @@
       </annotation>
       <annotation id="Team286_A494">
         <infon key="type">Gene</infon>
-        <location offset="34578" length="18"/>
+        <location offset="34579" length="18"/>
         <text>pGAL1-LST1 plasmid</text>
       </annotation>
       <annotation id="Team286_A495">
         <infon key="type">Gene</infon>
-        <location offset="34598" length="5"/>
+        <location offset="34599" length="5"/>
         <text>pKR35</text>
       </annotation>
       <annotation id="Team286_A496">
         <infon key="type">Gene</infon>
-        <location offset="34614" length="10"/>
+        <location offset="34615" length="10"/>
         <text>SEC24 gene</text>
       </annotation>
       <annotation id="Team286_A497">
         <infon key="type">Gene</infon>
-        <location offset="34643" length="5"/>
+        <location offset="34644" length="5"/>
         <text>pKR41</text>
       </annotation>
       <annotation id="Team286_A498">
         <infon key="type">Gene</infon>
-        <location offset="34777" length="5"/>
+        <location offset="34778" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A499">
         <infon key="type">Gene</infon>
-        <location offset="34856" length="5"/>
+        <location offset="34857" length="5"/>
         <text>SEC12</text>
       </annotation>
       <annotation id="Team286_A500">
         <infon key="type">Gene</infon>
-        <location offset="34863" length="5"/>
+        <location offset="34864" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A501">
         <infon key="type">Gene</infon>
-        <location offset="34870" length="5"/>
+        <location offset="34871" length="5"/>
         <text>SEC31</text>
       </annotation>
       <annotation id="Team286_A502">
         <infon key="type">Gene</infon>
-        <location offset="34880" length="5"/>
+        <location offset="34881" length="5"/>
         <text>SEC23</text>
       </annotation>
       <annotation id="Team286_A503">
         <infon key="type">Gene</infon>
-        <location offset="34939" length="5"/>
+        <location offset="34940" length="5"/>
         <text>SEC23</text>
       </annotation>
       <annotation id="Team286_A504">
         <infon key="type">Gene</infon>
-        <location offset="35076" length="5"/>
+        <location offset="35077" length="5"/>
         <text>SEC23</text>
       </annotation>
       <annotation id="Team286_A505">
         <infon key="type">Gene</infon>
-        <location offset="35134" length="5"/>
+        <location offset="35135" length="5"/>
         <text>SEC23</text>
       </annotation>
       <annotation id="Team286_A506">
         <infon key="type">Gene</infon>
-        <location offset="35263" length="5"/>
+        <location offset="35264" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A507">
         <infon key="type">Gene</infon>
-        <location offset="35330" length="5"/>
+        <location offset="35331" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A508">
         <infon key="type">Gene</infon>
-        <location offset="35340" length="6"/>
+        <location offset="35341" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A509">
         <infon key="type">Gene</infon>
-        <location offset="35391" length="22"/>
+        <location offset="35392" length="22"/>
         <text>vesicle coat complexes</text>
       </annotation>
       <annotation id="Team286_A510">
         <infon key="type">Gene</infon>
-        <location offset="35431" length="5"/>
+        <location offset="35432" length="5"/>
         <text>Lst1p</text>
       </annotation>
     </passage>
@@ -2946,12 +2946,12 @@
       </annotation>
       <annotation id="Team286_A527">
         <infon key="type">Gene</infon>
-        <location offset="37960" length="16"/>
+        <location offset="37961" length="16"/>
         <text>lst1Delta mutant</text>
       </annotation>
       <annotation id="Team286_A528">
         <infon key="type">Gene</infon>
-        <location offset="38014" length="5"/>
+        <location offset="38015" length="5"/>
         <text>Pma1p</text>
       </annotation>
     </passage>
@@ -3051,37 +3051,37 @@
       </annotation>
       <annotation id="Team286_A545">
         <infon key="type">Gene</infon>
-        <location offset="39526" length="25"/>
+        <location offset="39527" length="25"/>
         <text>ER from lst1Delta mutants</text>
       </annotation>
       <annotation id="Team286_A546">
         <infon key="type">Gene</infon>
-        <location offset="39564" length="6"/>
+        <location offset="39565" length="6"/>
         <text>Sec61p</text>
       </annotation>
       <annotation id="Team286_A547">
         <infon key="type">Gene</infon>
-        <location offset="39664" length="5"/>
+        <location offset="39665" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A548">
         <infon key="type">Gene</infon>
-        <location offset="39771" length="5"/>
+        <location offset="39772" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A549">
         <infon key="type">Gene</infon>
-        <location offset="39918" length="5"/>
+        <location offset="39919" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A550">
         <infon key="type">Gene</infon>
-        <location offset="39976" length="2"/>
+        <location offset="39977" length="2"/>
         <text>ER</text>
       </annotation>
       <annotation id="Team286_A551">
         <infon key="type">Gene</infon>
-        <location offset="40013" length="4"/>
+        <location offset="40014" length="4"/>
         <text>PMA1</text>
       </annotation>
     </passage>
@@ -3116,32 +3116,32 @@
       </annotation>
       <annotation id="Team286_A557">
         <infon key="type">Gene</infon>
-        <location offset="40289" length="18"/>
+        <location offset="40290" length="18"/>
         <text>lst1Delta  mutants</text>
       </annotation>
       <annotation id="Team286_A558">
         <infon key="type">Gene</infon>
-        <location offset="40344" length="17"/>
+        <location offset="40345" length="17"/>
         <text>lst1Delta mutants</text>
       </annotation>
       <annotation id="Team286_A559">
         <infon key="type">Gene</infon>
-        <location offset="40418" length="9"/>
+        <location offset="40419" length="9"/>
         <text>lst1Delta</text>
       </annotation>
       <annotation id="Team286_A560">
         <infon key="type">Gene</infon>
-        <location offset="40661" length="9"/>
+        <location offset="40662" length="9"/>
         <text>invertase</text>
       </annotation>
       <annotation id="Team286_A561">
         <infon key="type">Gene</infon>
-        <location offset="40752" length="9"/>
+        <location offset="40753" length="9"/>
         <text>invertase</text>
       </annotation>
       <annotation id="Team286_A562">
         <infon key="type">Gene</infon>
-        <location offset="40945" length="18"/>
+        <location offset="40946" length="18"/>
         <text>carboxypeptidase Y</text>
       </annotation>
     </passage>
@@ -3186,17 +3186,17 @@
       </annotation>
       <annotation id="Team286_A570">
         <infon key="type">Gene</infon>
-        <location offset="41863" length="10"/>
+        <location offset="41864" length="10"/>
         <text>COPII gene</text>
       </annotation>
       <annotation id="Team286_A571">
         <infon key="type">Gene</infon>
-        <location offset="41902" length="9"/>
+        <location offset="41903" length="9"/>
         <text>lst1Delta</text>
       </annotation>
       <annotation id="Team286_A572">
         <infon key="type">Gene</infon>
-        <location offset="41958" length="5"/>
+        <location offset="41959" length="5"/>
         <text>Pma1p</text>
       </annotation>
     </passage>
@@ -3301,32 +3301,32 @@
       </annotation>
       <annotation id="Team286_A590">
         <infon key="type">Gene</infon>
-        <location offset="43452" length="8"/>
+        <location offset="43453" length="8"/>
         <text>Lst1p-HA</text>
       </annotation>
       <annotation id="Team286_A591">
         <infon key="type">Gene</infon>
-        <location offset="43714" length="13"/>
+        <location offset="43715" length="13"/>
         <text>Lst1p protein</text>
       </annotation>
       <annotation id="Team286_A592">
         <infon key="type">Gene</infon>
-        <location offset="44000" length="8"/>
+        <location offset="44002" length="8"/>
         <text>Lst1p-HA</text>
       </annotation>
       <annotation id="Team286_A593">
         <infon key="type">Gene</infon>
-        <location offset="44037" length="8"/>
+        <location offset="44039" length="8"/>
         <text>Fig. 9 B</text>
       </annotation>
       <annotation id="Team286_A594">
         <infon key="type">Gene</infon>
-        <location offset="44077" length="8"/>
+        <location offset="44079" length="8"/>
         <text>Lst1p-HA</text>
       </annotation>
       <annotation id="Team286_A595">
         <infon key="type">Gene</infon>
-        <location offset="44148" length="5"/>
+        <location offset="44150" length="5"/>
         <text>Lst1p</text>
       </annotation>
     </passage>
@@ -3346,7 +3346,7 @@
       </annotation>
       <annotation id="TEAM_336_PPI4">
         <infon key="type">PPImention</infon>
-        <location offset="44229" length="18"/>
+        <location offset="44229" length="18" original_offset="0"/>
         <text>Lst1p Binds Sec23p</text>
       </annotation>
     </passage>
@@ -3556,12 +3556,12 @@
       </annotation>
       <annotation id="TEAM_336_PPI5">
         <infon key="type">PPImention</infon>
-        <location offset="45031" length="120"/>
+        <location offset="45031" length="120" original_offset="0"/>
         <text>To confirm the interaction between Lst1p and Sec23p,  association of these proteins was examined in yeast cell extracts.</text>
       </annotation>
       <annotation id="TEAM_336_PPI6">
         <infon key="type">PPImention</infon>
-        <location offset="45913" length="90"/>
+        <location offset="45913" length="90" original_offset="0"/>
         <text>Together, these experiments show that Lst1p, like Sec24p,  can form a complex with Sec23p.</text>
       </annotation>
     </passage>
@@ -3581,232 +3581,232 @@
       </annotation>
       <annotation id="Team286_A639">
         <infon key="type">Gene</infon>
-        <location offset="46173" length="6"/>
+        <location offset="46174" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A640">
         <infon key="type">Gene</infon>
-        <location offset="46189" length="3"/>
+        <location offset="46190" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A641">
         <infon key="type">Gene</infon>
-        <location offset="46193" length="5"/>
+        <location offset="46194" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A642">
         <infon key="type">Gene</infon>
-        <location offset="46199" length="2"/>
+        <location offset="46200" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A643">
         <infon key="type">Gene</infon>
-        <location offset="46237" length="5"/>
+        <location offset="46238" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A644">
         <infon key="type">Gene</infon>
-        <location offset="46243" length="6"/>
+        <location offset="46244" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A645">
         <infon key="type">Gene</infon>
-        <location offset="46343" length="3"/>
+        <location offset="46345" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A646">
         <infon key="type">Gene</infon>
-        <location offset="46347" length="5"/>
+        <location offset="46349" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A647">
         <infon key="type">Gene</infon>
-        <location offset="46353" length="2"/>
+        <location offset="46355" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A648">
         <infon key="type">Gene</infon>
-        <location offset="46360" length="6"/>
+        <location offset="46362" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A649">
         <infon key="type">Gene</infon>
-        <location offset="46416" length="6"/>
+        <location offset="46418" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A650">
         <infon key="type">Gene</infon>
-        <location offset="46440" length="3"/>
+        <location offset="46442" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A651">
         <infon key="type">Gene</infon>
-        <location offset="46444" length="5"/>
+        <location offset="46446" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A652">
         <infon key="type">Gene</infon>
-        <location offset="46450" length="2"/>
+        <location offset="46452" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A653">
         <infon key="type">Gene</infon>
-        <location offset="46573" length="27"/>
+        <location offset="46575" length="27"/>
         <text>ER membrane protein  Sec61p</text>
       </annotation>
       <annotation id="Team286_A654">
         <infon key="type">Gene</infon>
-        <location offset="46759" length="3"/>
+        <location offset="46761" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A655">
         <infon key="type">Gene</infon>
-        <location offset="46764" length="5"/>
+        <location offset="46766" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A656">
         <infon key="type">Gene</infon>
-        <location offset="46770" length="2"/>
+        <location offset="46772" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A657">
         <infon key="type">Gene</infon>
-        <location offset="46777" length="6"/>
+        <location offset="46779" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A658">
         <infon key="type">Gene</infon>
-        <location offset="46808" length="29"/>
+        <location offset="46810" length="29"/>
         <text>ER resident  membrane protein</text>
       </annotation>
       <annotation id="Team286_A659">
         <infon key="type">Gene</infon>
-        <location offset="46839" length="6"/>
+        <location offset="46841" length="6"/>
         <text>Sec61p</text>
       </annotation>
       <annotation id="Team286_A660">
         <infon key="type">Gene</infon>
-        <location offset="46904" length="3"/>
+        <location offset="46906" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A661">
         <infon key="type">Gene</infon>
-        <location offset="46908" length="5"/>
+        <location offset="46910" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A662">
         <infon key="type">Gene</infon>
-        <location offset="46914" length="2"/>
+        <location offset="46916" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A663">
         <infon key="type">Gene</infon>
-        <location offset="46921" length="6"/>
+        <location offset="46923" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A664">
         <infon key="type">Gene</infon>
-        <location offset="47007" length="6"/>
+        <location offset="47009" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A665">
         <infon key="type">Gene</infon>
-        <location offset="47018" length="3"/>
+        <location offset="47020" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A666">
         <infon key="type">Gene</infon>
-        <location offset="47022" length="5"/>
+        <location offset="47024" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A667">
         <infon key="type">Gene</infon>
-        <location offset="47028" length="2"/>
+        <location offset="47030" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A668">
         <infon key="type">Gene</infon>
-        <location offset="47069" length="6"/>
+        <location offset="47071" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A669">
         <infon key="type">Gene</infon>
-        <location offset="47138" length="6"/>
+        <location offset="47140" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A670">
         <infon key="type">Gene</infon>
-        <location offset="47175" length="3"/>
+        <location offset="47177" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A671">
         <infon key="type">Gene</infon>
-        <location offset="47179" length="5"/>
+        <location offset="47181" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A672">
         <infon key="type">Gene</infon>
-        <location offset="47185" length="2"/>
+        <location offset="47187" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A673">
         <infon key="type">Gene</infon>
-        <location offset="47246" length="3"/>
+        <location offset="47248" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A674">
         <infon key="type">Gene</infon>
-        <location offset="47250" length="5"/>
+        <location offset="47252" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A675">
         <infon key="type">Gene</infon>
-        <location offset="47297" length="6"/>
+        <location offset="47299" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A676">
         <infon key="type">Gene</infon>
-        <location offset="47307" length="3"/>
+        <location offset="47309" length="3"/>
         <text>GST</text>
       </annotation>
       <annotation id="Team286_A677">
         <infon key="type">Gene</infon>
-        <location offset="47311" length="5"/>
+        <location offset="47313" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A678">
         <infon key="type">Gene</infon>
-        <location offset="47317" length="2"/>
+        <location offset="47319" length="2"/>
         <text>HA</text>
       </annotation>
       <annotation id="Team286_A679">
         <infon key="type">Gene</infon>
-        <location offset="47541" length="5"/>
+        <location offset="47543" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A680">
         <infon key="type">Gene</infon>
-        <location offset="47572" length="6"/>
+        <location offset="47574" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A681">
         <infon key="type">Gene</infon>
-        <location offset="47593" length="5"/>
+        <location offset="47595" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A682">
         <infon key="type">Gene</infon>
-        <location offset="47600" length="6"/>
+        <location offset="47602" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="TEAM_336_PPI7">
         <infon key="type">PPImention</infon>
-        <location offset="46119" length="213"/>
+        <location offset="46120" length="213" original_offset="0"/>
         <text>While working out conditions to optimize recovery of  Sec23p bound to GST-Lst1p-HA, we discovered that assembly of an Lst1p/Sec23p complex appears to enhance  the association of both proteins with the ER membrane.</text>
       </annotation>
       <annotation id="TEAM_336_PPI8">
         <infon key="type">PPImention</infon>
-        <location offset="47501" length="144"/>
+        <location offset="47503" length="144" original_offset="0"/>
         <text>These data support the observation that Lst1p  can form a complex with Sec23p, and that the Lst1p/ Sec23p complex has affinity for ER membranes.</text>
       </annotation>
     </passage>
@@ -3946,62 +3946,62 @@
       </annotation>
       <annotation id="Team286_A708">
         <infon key="type">Gene</infon>
-        <location offset="48914" length="6"/>
+        <location offset="48915" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A709">
         <infon key="type">Gene</infon>
-        <location offset="48921" length="5"/>
+        <location offset="48922" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A710">
         <infon key="type">Gene</infon>
-        <location offset="48988" length="5"/>
+        <location offset="48989" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A711">
         <infon key="type">Gene</infon>
-        <location offset="48999" length="6"/>
+        <location offset="49000" length="6"/>
         <text>Sec23p</text>
       </annotation>
       <annotation id="Team286_A712">
         <infon key="type">Gene</infon>
-        <location offset="49202" length="4"/>
+        <location offset="49203" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A713">
         <infon key="type">Gene</infon>
-        <location offset="49319" length="5"/>
+        <location offset="49320" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A714">
         <infon key="type">Gene</infon>
-        <location offset="49333" length="2"/>
+        <location offset="49334" length="2"/>
         <text>ER</text>
       </annotation>
       <annotation id="Team286_A715">
         <infon key="type">Gene</infon>
-        <location offset="49432" length="5"/>
+        <location offset="49434" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A716">
         <infon key="type">Gene</infon>
-        <location offset="49458" length="6"/>
+        <location offset="49460" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A717">
         <infon key="type">Gene</infon>
-        <location offset="49482" length="18"/>
+        <location offset="49484" length="18"/>
         <text>COPII coat complex</text>
       </annotation>
       <annotation id="Team286_A718">
         <infon key="type">Gene</infon>
-        <location offset="49538" length="5"/>
+        <location offset="49540" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="TEAM_336_PPI9">
         <infon key="type">PPImention</infon>
-        <location offset="48738" length="154"/>
+        <location offset="48738" length="154" original_offset="0"/>
         <text>(III) Lst1p, like Sec24p, can bind to Sec23p  as shown by tests for two-hybrid interaction and affinity purification of a complex of GST-Lst1p and Sec23p.</text>
       </annotation>
     </passage>
@@ -4426,32 +4426,32 @@
       </annotation>
       <annotation id="Team286_A796">
         <infon key="type">Gene</infon>
-        <location offset="55725" length="5"/>
+        <location offset="55726" length="5"/>
         <text>Lst1p</text>
       </annotation>
       <annotation id="Team286_A797">
         <infon key="type">Gene</infon>
-        <location offset="55760" length="6"/>
+        <location offset="55761" length="6"/>
         <text>Sec24p</text>
       </annotation>
       <annotation id="Team286_A798">
         <infon key="type">Gene</infon>
-        <location offset="55800" length="5"/>
+        <location offset="55801" length="5"/>
         <text>Pma1p</text>
       </annotation>
       <annotation id="Team286_A799">
         <infon key="type">Gene</infon>
-        <location offset="55845" length="12"/>
+        <location offset="55847" length="12"/>
         <text>Sec24 family</text>
       </annotation>
       <annotation id="TEAM_336_PPI10">
         <infon key="type">PPImention</infon>
-        <location offset="55027" length="257"/>
+        <location offset="55027" length="257" original_offset="0"/>
         <text>Using  ER-derived microsomes and purified COPII components,  Kuehn et al. (1998) have shown that the Sec23p/Sec24p  complex, along with Sar1p, associate with amino acid permeases and other integral membrane protein that are destined for the plasma membrane.</text>
       </annotation>
       <annotation id="TEAM_336_PPI11">
         <infon key="type">PPImention</infon>
-        <location offset="55498" length="192"/>
+        <location offset="55498" length="192" original_offset="0"/>
         <text>The conclusion from both experimental systems is that the Sec23p/Sec24p complex contains specific binding sites for the capture of membrane  cargo proteins within the plane of the ER membrane.</text>
       </annotation>
     </passage>
@@ -4531,7 +4531,7 @@
       </annotation>
       <annotation id="TEAM_336_PPI12">
         <infon key="type">PPImention</infon>
-        <location offset="56337" length="495"/>
+        <location offset="56337" length="495" original_offset="0"/>
         <text>In future experiments, it  may be possible to isolate vesicles coated with Lst1p by  performing an in vitro budding reaction using purified cytosolic components, including a purified complex of Lst1p  and Sec23p. It may also be possible to determine whether  vesicles that are formed using a Sec23p/Lst1p complex  more efficiently incorporate Pma1p than vesicles formed  using the Sec23p/Sec24p complex. Finally, it will be of interest to determine if there is direct binding of Lst1p to  Pma1p.</text>
       </annotation>
     </passage>
@@ -4626,12 +4626,12 @@
       </annotation>
       <annotation id="TEAM_336_PPI13">
         <infon key="type">PPImention</infon>
-        <location offset="56999" length="139"/>
+        <location offset="56999" length="139" original_offset="0"/>
         <text>It is  possible that Sec23p/Lst1p complexes act to form a class of  vesicle that is distinct from those formed by Sec23p/ Sec24p complexes.</text>
       </annotation>
       <annotation id="TEAM_336_PPI14">
         <infon key="type">PPImention</infon>
-        <location offset="57403" length="208"/>
+        <location offset="57403" length="208" original_offset="0"/>
         <text>We  have identified a third Sec24p family member, which we  call Iss1p, as a protein that binds to Sec16p. Iss1p  (YNL049c) also binds Sec23p and appears to be associated  with the ER membrane (Gimeno, 1996).</text>
       </annotation>
     </passage>
@@ -4651,297 +4651,297 @@
       <text>Strain  Genotype  Source or reference   CUY563  MATaade2-101 ade3-24 leu2-3,112 ura3-52  T. Huffaker (Cornell University)  CUY564  MATalpha ade2-101 ade3-2 leu2-3,112 ura3-52  T. Huffaker (Cornell University)  EGY40  MATalpha ura3-52 leu2 his3 trp1  Golemis and Brent, 1992  CKY45  MATalpha sec13-1 his4-619 ura3-52  Kaiser Lab Collection  CKY50  MATalpha sec16-2 his4-619 ura3-52  Kaiser Lab Collection  CKY54  MATalpha sec17-1 his4-619 ura3-52  Kaiser Lab Collection  CKY58  MATalpha sec18-1 his4-619 ura3-52  Kaiser Lab Collection  CKY78  MATalpha sec23-1 his4-619 ura3-52  Kaiser Lab Collection  CKY348  MATa/alpha leu2-3/leu2-3 ura3-52/ura3-52  Kaiser Lab Collection  CKY423  MATalpha sec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52 [pKR4]    CKY424  MATasec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52 [pKR4]    CKY426  MATalst1-1sec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52 [pKR4]    CKY435  MATalst1-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY436  MATalst2-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY437  MATalst3-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY438  MATalst4-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY439  MATalst5-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY440  MATalst6-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY441  MATalst7-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY442  MATalst8-1 sec13-1::[SEC13, URA3] ade2-101 ade3-24 leu2-3,112 ura3-52    CKY443  MATa prototroph  Kaiser Lab Collection  CKY473  MATaleu2-3,112 ura3-52 Gal+  Kaiser Lab Collection  CKY534  MATalpha lst1Delta::LEU2 leu2-3,112 ura3-52 [pKR17HA]    CKY535  MATalst1Delta::LEU2 leu2-3,112 ura3-52 [pKR17HA]    CKY536  MATalst1Delta::LEU2 ura3-52 leu2-3,112    CKY540  MATaleu2-3,112 ura3-52 [pNV31]    CKY541  MATasec12-4 ura3-52 [pNV31]    CKY542  MATalst1Delta::LEU2 leu2-3,112 ura3-52 [pNV31]    CKY552  MATalpha lst1Delta::LEU2 leu2-3,112 ura3-52</text>
       <annotation id="Team286_A831">
         <infon key="type">Gene</infon>
-        <location offset="58193" length="35"/>
+        <location offset="58196" length="35"/>
         <text>CUY563  MATaade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A832">
         <infon key="type">Gene</infon>
-        <location offset="58284" length="31"/>
+        <location offset="58287" length="31"/>
         <text>MATalpha ade2-101 ade3-2 leu2-3</text>
       </annotation>
       <annotation id="Team286_A833">
         <infon key="type">Gene</infon>
-        <location offset="58370" length="175"/>
+        <location offset="58373" length="175"/>
         <text>MATalpha ura3-52 leu2 his3 trp1  Golemis and Brent, 1992  CKY45  MATalpha sec13-1 his4-619 ura3-52  Kaiser Lab Collection  CKY50  MATalpha sec16-2 his4-619 ura3-52  Kaiser Lab</text>
       </annotation>
       <annotation id="Team286_A834">
         <infon key="type">Gene</infon>
-        <location offset="58558" length="52"/>
+        <location offset="58561" length="52"/>
         <text>CKY54  MATalpha sec17-1 his4-619 ura3-52  Kaiser Lab</text>
       </annotation>
       <annotation id="Team286_A835">
         <infon key="type">Gene</infon>
-        <location offset="58623" length="117"/>
+        <location offset="58626" length="117"/>
         <text>CKY58  MATalpha sec18-1 his4-619 ura3-52  Kaiser Lab Collection  CKY78  MATalpha sec23-1 his4-619 ura3-52  Kaiser Lab</text>
       </annotation>
       <annotation id="Team286_A836">
         <infon key="type">Gene</infon>
-        <location offset="58753" length="25"/>
+        <location offset="58756" length="25"/>
         <text>CKY348  MATa/alpha leu2-3</text>
       </annotation>
       <annotation id="Team286_A837">
         <infon key="type">Gene</infon>
-        <location offset="58779" length="14"/>
+        <location offset="58782" length="14"/>
         <text>leu2-3 ura3-52</text>
       </annotation>
       <annotation id="Team286_A838">
         <infon key="type">Gene</infon>
-        <location offset="58794" length="158"/>
+        <location offset="58797" length="158"/>
         <text>ura3-52  Kaiser Lab Collection  CKY423  MATalpha sec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52 [pKR4]    CKY424  MATasec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52</text>
       </annotation>
       <annotation id="Team286_A839">
         <infon key="type">Gene</infon>
-        <location offset="58954" length="4"/>
+        <location offset="58957" length="4"/>
         <text>pKR4</text>
       </annotation>
       <annotation id="Team286_A840">
         <infon key="type">Gene</infon>
-        <location offset="58963" length="61"/>
+        <location offset="58966" length="61"/>
         <text>CKY426  MATalst1-1sec13-1 ade2-101 ade3-24 leu2-3,112 ura3-52</text>
       </annotation>
       <annotation id="Team286_A841">
         <infon key="type">Gene</infon>
-        <location offset="59026" length="4"/>
+        <location offset="59029" length="4"/>
         <text>pKR4</text>
       </annotation>
       <annotation id="Team286_A842">
         <infon key="type">Gene</infon>
-        <location offset="59035" length="26"/>
+        <location offset="59038" length="26"/>
         <text>CKY435  MATalst1-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A843">
         <infon key="type">Gene</infon>
-        <location offset="59064" length="5"/>
+        <location offset="59067" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A844">
         <infon key="type">Gene</infon>
-        <location offset="59071" length="4"/>
+        <location offset="59074" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A845">
         <infon key="type">Gene</infon>
-        <location offset="59077" length="23"/>
+        <location offset="59080" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A846">
         <infon key="type">Gene</infon>
-        <location offset="59101" length="3"/>
+        <location offset="59104" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A847">
         <infon key="type">Gene</infon>
-        <location offset="59105" length="37"/>
+        <location offset="59108" length="37"/>
         <text>ura3-52    CKY436  MATalst2-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A848">
         <infon key="type">Gene</infon>
-        <location offset="59145" length="5"/>
+        <location offset="59148" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A849">
         <infon key="type">Gene</infon>
-        <location offset="59152" length="4"/>
+        <location offset="59155" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A850">
         <infon key="type">Gene</infon>
-        <location offset="59158" length="23"/>
+        <location offset="59161" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A851">
         <infon key="type">Gene</infon>
-        <location offset="59182" length="3"/>
+        <location offset="59185" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A852">
         <infon key="type">Gene</infon>
-        <location offset="59186" length="37"/>
+        <location offset="59189" length="37"/>
         <text>ura3-52    CKY437  MATalst3-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A853">
         <infon key="type">Gene</infon>
-        <location offset="59226" length="5"/>
+        <location offset="59229" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A854">
         <infon key="type">Gene</infon>
-        <location offset="59233" length="4"/>
+        <location offset="59236" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A855">
         <infon key="type">Gene</infon>
-        <location offset="59239" length="23"/>
+        <location offset="59242" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A856">
         <infon key="type">Gene</infon>
-        <location offset="59263" length="3"/>
+        <location offset="59266" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A857">
         <infon key="type">Gene</infon>
-        <location offset="59267" length="37"/>
+        <location offset="59270" length="37"/>
         <text>ura3-52    CKY438  MATalst4-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A858">
         <infon key="type">Gene</infon>
-        <location offset="59307" length="5"/>
+        <location offset="59310" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A859">
         <infon key="type">Gene</infon>
-        <location offset="59314" length="4"/>
+        <location offset="59317" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A860">
         <infon key="type">Gene</infon>
-        <location offset="59320" length="23"/>
+        <location offset="59323" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A861">
         <infon key="type">Gene</infon>
-        <location offset="59344" length="3"/>
+        <location offset="59347" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A862">
         <infon key="type">Gene</infon>
-        <location offset="59348" length="37"/>
+        <location offset="59351" length="37"/>
         <text>ura3-52    CKY439  MATalst5-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A863">
         <infon key="type">Gene</infon>
-        <location offset="59388" length="5"/>
+        <location offset="59391" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A864">
         <infon key="type">Gene</infon>
-        <location offset="59395" length="4"/>
+        <location offset="59398" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A865">
         <infon key="type">Gene</infon>
-        <location offset="59401" length="23"/>
+        <location offset="59404" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A866">
         <infon key="type">Gene</infon>
-        <location offset="59425" length="3"/>
+        <location offset="59428" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A867">
         <infon key="type">Gene</infon>
-        <location offset="59429" length="37"/>
+        <location offset="59432" length="37"/>
         <text>ura3-52    CKY440  MATalst6-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A868">
         <infon key="type">Gene</infon>
-        <location offset="59469" length="5"/>
+        <location offset="59472" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A869">
         <infon key="type">Gene</infon>
-        <location offset="59476" length="4"/>
+        <location offset="59479" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A870">
         <infon key="type">Gene</infon>
-        <location offset="59482" length="23"/>
+        <location offset="59485" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A871">
         <infon key="type">Gene</infon>
-        <location offset="59506" length="3"/>
+        <location offset="59509" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A872">
         <infon key="type">Gene</infon>
-        <location offset="59510" length="37"/>
+        <location offset="59513" length="37"/>
         <text>ura3-52    CKY441  MATalst7-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A873">
         <infon key="type">Gene</infon>
-        <location offset="59550" length="5"/>
+        <location offset="59553" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A874">
         <infon key="type">Gene</infon>
-        <location offset="59557" length="4"/>
+        <location offset="59560" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A875">
         <infon key="type">Gene</infon>
-        <location offset="59563" length="23"/>
+        <location offset="59566" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A876">
         <infon key="type">Gene</infon>
-        <location offset="59587" length="3"/>
+        <location offset="59590" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A877">
         <infon key="type">Gene</infon>
-        <location offset="59591" length="37"/>
+        <location offset="59594" length="37"/>
         <text>ura3-52    CKY442  MATalst8-1 sec13-1</text>
       </annotation>
       <annotation id="Team286_A878">
         <infon key="type">Gene</infon>
-        <location offset="59631" length="5"/>
+        <location offset="59634" length="5"/>
         <text>SEC13</text>
       </annotation>
       <annotation id="Team286_A879">
         <infon key="type">Gene</infon>
-        <location offset="59638" length="4"/>
+        <location offset="59641" length="4"/>
         <text>URA3</text>
       </annotation>
       <annotation id="Team286_A880">
         <infon key="type">Gene</infon>
-        <location offset="59644" length="23"/>
+        <location offset="59647" length="23"/>
         <text>ade2-101 ade3-24 leu2-3</text>
       </annotation>
       <annotation id="Team286_A881">
         <infon key="type">Gene</infon>
-        <location offset="59668" length="3"/>
+        <location offset="59671" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A882">
         <infon key="type">Gene</infon>
-        <location offset="59672" length="145"/>
+        <location offset="59675" length="145"/>
         <text>ura3-52    CKY443  MATa prototroph  Kaiser Lab Collection  CKY473  MATaleu2-3,112 ura3-52 Gal+  Kaiser Lab Collection  CKY534  MATalpha lst1Delta</text>
       </annotation>
       <annotation id="Team286_A883">
         <infon key="type">Gene</infon>
-        <location offset="59819" length="58"/>
+        <location offset="59822" length="58"/>
         <text>LEU2 leu2-3,112 ura3-52 [pKR17HA]    CKY535  MATalst1Delta</text>
       </annotation>
       <annotation id="Team286_A884">
         <infon key="type">Gene</infon>
-        <location offset="59879" length="58"/>
+        <location offset="59882" length="58"/>
         <text>LEU2 leu2-3,112 ura3-52 [pKR17HA]    CKY536  MATalst1Delta</text>
       </annotation>
       <annotation id="Team286_A885">
         <infon key="type">Gene</infon>
-        <location offset="59939" length="129"/>
+        <location offset="59942" length="129"/>
         <text>LEU2 ura3-52 leu2-3,112    CKY540  MATaleu2-3,112 ura3-52 [pNV31]    CKY541  MATasec12-4 ura3-52 [pNV31]    CKY542  MATalst1Delta</text>
       </annotation>
       <annotation id="Team286_A886">
         <infon key="type">Gene</infon>
-        <location offset="60070" length="61"/>
+        <location offset="60073" length="61"/>
         <text>LEU2 leu2-3,112 ura3-52 [pNV31]    CKY552  MATalpha lst1Delta</text>
       </annotation>
       <annotation id="Team286_A887">
         <infon key="type">Gene</infon>
-        <location offset="60133" length="11"/>
+        <location offset="60136" length="11"/>
         <text>LEU2 leu2-3</text>
       </annotation>
       <annotation id="Team286_A888">
         <infon key="type">Gene</infon>
-        <location offset="60145" length="3"/>
+        <location offset="60148" length="3"/>
         <text>112</text>
       </annotation>
       <annotation id="Team286_A889">
         <infon key="type">Gene</infon>
-        <location offset="60149" length="7"/>
+        <location offset="60152" length="7"/>
         <text>ura3-52</text>
       </annotation>
     </passage>
@@ -5016,17 +5016,17 @@
       <text>Gene  Number of alleles   LST1  11  LST2   6  LST3   4  LST4   5  LST5   5  LST6   1  LST7   1  LST8   1  LST9   1  LST10 (SEC16)   2</text>
       <annotation id="Team286_A900">
         <infon key="type">Gene</infon>
-        <location offset="60755" length="14"/>
+        <location offset="60758" length="14"/>
         <text>LST1  11  LST2</text>
       </annotation>
       <annotation id="Team286_A901">
         <infon key="type">Gene</infon>
-        <location offset="60775" length="75"/>
+        <location offset="60778" length="75"/>
         <text>LST3   4  LST4   5  LST5   5  LST6   1  LST7   1  LST8   1  LST9   1  LST10</text>
       </annotation>
       <annotation id="Team286_A902">
         <infon key="type">Gene</infon>
-        <location offset="60852" length="5"/>
+        <location offset="60855" length="5"/>
         <text>SEC16</text>
       </annotation>
     </passage>
@@ -5041,27 +5041,27 @@
       <text>sec13-1  sec16-2  sec23-1  sec31-1  sec17-1  sec18-1   lst1-1  -  -  -  -  +  +  lst2-1  -  +  +  +  ND  ND  lst3-1  -  +  +  +  ND  ND  lst4-1  +/-  +  +  +  ND  ND  lst5-1  -  +  +  +  ND  ND  lst6-1  -  +/- -  +  -  +  +  lst7-1  -  +  +  +  ND  ND  lst8-1  -  +  +  +  ND  ND</text>
       <annotation id="Team286_A903">
         <infon key="type">Gene</infon>
-        <location offset="60918" length="76"/>
+        <location offset="60923" length="76"/>
         <text>sec13-1  sec16-2  sec23-1  sec31-1  sec17-1  sec18-1   lst1-1  -  -  -  -  +</text>
       </annotation>
       <annotation id="Team286_A904">
         <infon key="type">Gene</infon>
-        <location offset="60999" length="22"/>
+        <location offset="61004" length="22"/>
         <text>lst2-1  -  +  +  +  ND</text>
       </annotation>
       <annotation id="Team286_A905">
         <infon key="type">Gene</infon>
-        <location offset="61027" length="52"/>
+        <location offset="61032" length="52"/>
         <text>lst3-1  -  +  +  +  ND  ND  lst4-1  +/-  +  +  +  ND</text>
       </annotation>
       <annotation id="Team286_A906">
         <infon key="type">Gene</infon>
-        <location offset="61085" length="53"/>
+        <location offset="61090" length="53"/>
         <text>lst5-1  -  +  +  +  ND  ND  lst6-1  -  +/- -  +  -  +</text>
       </annotation>
       <annotation id="Team286_A907">
         <infon key="type">Gene</infon>
-        <location offset="61143" length="54"/>
+        <location offset="61148" length="54"/>
         <text>lst7-1  -  +  +  +  ND  ND  lst8-1  -  +  +  +  ND  ND</text>
       </annotation>
     </passage>
@@ -5101,87 +5101,87 @@
       </annotation>
       <annotation id="Team286_A912">
         <infon key="type">Gene</infon>
-        <location offset="61575" length="17"/>
+        <location offset="61576" length="17"/>
         <text>lst1Delta mutants</text>
       </annotation>
       <annotation id="Team286_A913">
         <infon key="type">Gene</infon>
-        <location offset="61661" length="4"/>
+        <location offset="61662" length="4"/>
         <text>LEU2</text>
       </annotation>
       <annotation id="Team286_A914">
         <infon key="type">Gene</infon>
-        <location offset="61667" length="6"/>
+        <location offset="61668" length="6"/>
         <text>CKY534</text>
       </annotation>
       <annotation id="Team286_A915">
         <infon key="type">Gene</infon>
-        <location offset="61862" length="4"/>
+        <location offset="61863" length="4"/>
         <text>LEU2</text>
       </annotation>
       <annotation id="Team286_A916">
         <infon key="type">Gene</infon>
-        <location offset="61919" length="6"/>
+        <location offset="61920" length="6"/>
         <text>pRS316</text>
       </annotation>
       <annotation id="Team286_A917">
         <infon key="type">Gene</infon>
-        <location offset="61928" length="4"/>
+        <location offset="61929" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A918">
         <infon key="type">Gene</infon>
-        <location offset="61959" length="5"/>
+        <location offset="61960" length="5"/>
         <text>pKR17</text>
       </annotation>
       <annotation id="Team286_A919">
         <infon key="type">Gene</infon>
-        <location offset="61966" length="5"/>
+        <location offset="61967" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A920">
         <infon key="type">Gene</infon>
-        <location offset="61999" length="5"/>
+        <location offset="62000" length="5"/>
         <text>pAF70</text>
       </annotation>
       <annotation id="Team286_A921">
         <infon key="type">Gene</infon>
-        <location offset="62009" length="5"/>
+        <location offset="62010" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A922">
         <infon key="type">Gene</infon>
-        <location offset="62033" length="5"/>
+        <location offset="62034" length="5"/>
         <text>pKR34</text>
       </annotation>
       <annotation id="Team286_A923">
         <infon key="type">Gene</infon>
-        <location offset="62217" length="5"/>
+        <location offset="62218" length="5"/>
         <text>pGAL1</text>
       </annotation>
       <annotation id="Team286_A924">
         <infon key="type">Gene</infon>
-        <location offset="62223" length="4"/>
+        <location offset="62224" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A925">
         <infon key="type">Gene</infon>
-        <location offset="62229" length="5"/>
+        <location offset="62230" length="5"/>
         <text>pKR35</text>
       </annotation>
       <annotation id="Team286_A926">
         <infon key="type">Gene</infon>
-        <location offset="62274" length="5"/>
+        <location offset="62275" length="5"/>
         <text>pKR35</text>
       </annotation>
       <annotation id="Team286_A927">
         <infon key="type">Gene</infon>
-        <location offset="62284" length="5"/>
+        <location offset="62285" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A928">
         <infon key="type">Gene</infon>
-        <location offset="62308" length="5"/>
+        <location offset="62309" length="5"/>
         <text>pKR41</text>
       </annotation>
     </passage>
@@ -5201,32 +5201,32 @@
       </annotation>
       <annotation id="Team286_A931">
         <infon key="type">Gene</infon>
-        <location offset="62800" length="19"/>
+        <location offset="62801" length="19"/>
         <text>anti-Pma1p antibody</text>
       </annotation>
       <annotation id="Team286_A932">
         <infon key="type">Gene</infon>
-        <location offset="62989" length="6"/>
+        <location offset="62990" length="6"/>
         <text>CKY536</text>
       </annotation>
       <annotation id="Team286_A933">
         <infon key="type">Gene</infon>
-        <location offset="63100" length="18"/>
+        <location offset="63101" length="18"/>
         <text>LST1 plasmid pKR17</text>
       </annotation>
       <annotation id="Team286_A934">
         <infon key="type">Gene</infon>
-        <location offset="63167" length="5"/>
+        <location offset="63168" length="5"/>
         <text>SEC24</text>
       </annotation>
       <annotation id="Team286_A935">
         <infon key="type">Gene</infon>
-        <location offset="63174" length="6"/>
+        <location offset="63175" length="6"/>
         <text>CKY536</text>
       </annotation>
       <annotation id="Team286_A936">
         <infon key="type">Gene</infon>
-        <location offset="63194" length="24"/>
+        <location offset="63195" length="24"/>
         <text>2mu SEC24  plasmid pKR34</text>
       </annotation>
     </passage>
@@ -5246,12 +5246,12 @@
       </annotation>
       <annotation id="Team286_A939">
         <infon key="type">Gene</infon>
-        <location offset="63664" length="9"/>
+        <location offset="63665" length="9"/>
         <text>lst1Delta</text>
       </annotation>
       <annotation id="Team286_A940">
         <infon key="type">Gene</infon>
-        <location offset="63676" length="6"/>
+        <location offset="63677" length="6"/>
         <text>CKY536</text>
       </annotation>
     </passage>
@@ -5441,12 +5441,12 @@
       </annotation>
       <annotation id="Team286_A974">
         <infon key="type">Gene</infon>
-        <location offset="66327" length="8"/>
+        <location offset="66328" length="8"/>
         <text>Lst1p-HA</text>
       </annotation>
       <annotation id="Team286_A975">
         <infon key="type">Gene</infon>
-        <location offset="66386" length="16"/>
+        <location offset="66387" length="16"/>
         <text>anti-HA antibody</text>
       </annotation>
     </passage>
@@ -5466,7 +5466,7 @@
       </annotation>
       <annotation id="TEAM_336_PPI15">
         <infon key="type">PPImention</infon>
-        <location offset="66406" length="45"/>
+        <location offset="66406" length="45" original_offset="0"/>
         <text>Two-Hybrid Interaction between LST1 and SEC23</text>
       </annotation>
     </passage>
@@ -5476,17 +5476,17 @@
       <text>beta-galactosidase activity  LST1  SEC24  No fusion   SEC23  395 +- 8  629 +- 1  24.4 +- 0.1  No fusion  30.4 +- 4.0  25.3 +- 1.4  44.8 +- 5.3</text>
       <annotation id="Team286_A978">
         <infon key="type">Gene</infon>
-        <location offset="66453" length="18"/>
+        <location offset="66458" length="18"/>
         <text>beta-galactosidase</text>
       </annotation>
       <annotation id="Team286_A979">
         <infon key="type">Gene</infon>
-        <location offset="66482" length="4"/>
+        <location offset="66487" length="4"/>
         <text>LST1</text>
       </annotation>
       <annotation id="Team286_A980">
         <infon key="type">Gene</infon>
-        <location offset="66488" length="5"/>
+        <location offset="66493" length="5"/>
         <text>SEC24</text>
       </annotation>
     </passage>
@@ -5601,7 +5601,7 @@
       </annotation>
       <annotation id="TEAM_336_PPI16">
         <infon key="type">PPImention</infon>
-        <location offset="66859" length="97"/>
+        <location offset="66859" length="97" original_offset="0"/>
         <text>Lst1p/-Sec23p complex is membrane associated. (A)  Affinity isolation of Lst1p/-Sec23p complexes.</text>
       </annotation>
     </passage>
@@ -5883,7 +5883,7 @@
       <text>Yeast SEC16gene encodes a multidomain vesicle coat protein that interacts with Sec23p</text>
       <annotation id="TEAM_336_PPI17">
         <infon key="type">PPImention</infon>
-        <location offset="69406" length="85"/>
+        <location offset="69406" length="85" original_offset="0"/>
         <text>Yeast SEC16gene encodes a multidomain vesicle coat protein that interacts with Sec23p</text>
       </annotation>
     </passage>
@@ -5907,7 +5907,7 @@
       <text>SED4encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation</text>
       <annotation id="TEAM_336_PPI18">
         <infon key="type">PPImention</infon>
-        <location offset="69493" length="105"/>
+        <location offset="69493" length="105" original_offset="0"/>
         <text>SED4encodes a yeast endoplasmic reticulum protein that binds Sec16p and participates in vesicle formation</text>
       </annotation>
     </passage>
@@ -5925,7 +5925,7 @@
       <text>COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p</text>
       <annotation id="TEAM_336_PPI19">
         <infon key="type">PPImention</infon>
-        <location offset="69599" length="85"/>
+        <location offset="69599" length="85" original_offset="0"/>
         <text>COPII coat subunit interactions: Sec24p and Sec23p bind to adjacent regions of Sec16p</text>
       </annotation>
     </passage>
@@ -5958,7 +5958,7 @@
       <text>Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2</text>
       <annotation id="TEAM_336_PPI20">
         <infon key="type">PPImention</infon>
-        <location offset="69735" length="74"/>
+        <location offset="69735" length="74" original_offset="0"/>
         <text>Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2</text>
       </annotation>
     </passage>