roebe 0.5.123
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- data/lib/roebe/yaml/kernel_config/kernel_config.yml +79 -0
- data/lib/roebe/yaml/linux_kernel_settings.yml +11 -0
- data/lib/roebe/yaml/ls_colors.yml +17 -0
- data/lib/roebe/yaml/main_avi.yml +1 -0
- data/lib/roebe/yaml/main_editor.yml +1 -0
- data/lib/roebe/yaml/main_jpg.yml +1 -0
- data/lib/roebe/yaml/main_pdf.yml +1 -0
- data/lib/roebe/yaml/main_png.yml +1 -0
- data/lib/roebe/yaml/mark_this_directory.yml +1 -0
- data/lib/roebe/yaml/mime/mime.yml +615 -0
- data/lib/roebe/yaml/mime_types.yml +37 -0
- data/lib/roebe/yaml/monitors/monitors.yml +127 -0
- data/lib/roebe/yaml/n_people_in_these_countries.yml +31 -0
- data/lib/roebe/yaml/name_for_the_wireless_interface.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf1.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf2.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf3.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf4.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf5.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf6.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf7.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf8.yml +1 -0
- data/lib/roebe/yaml/pdf/pdf9.yml +1 -0
- data/lib/roebe/yaml/peoples_age.yml +6 -0
- data/lib/roebe/yaml/ports/ports.yml +50 -0
- data/lib/roebe/yaml/posix_character_classes.yml +13 -0
- data/lib/roebe/yaml/project_base_directory.yml +0 -0
- data/lib/roebe/yaml/rufnummern_in_/303/266sterreich/rufnummern_in_/303/266sterreich.yml +5 -0
- data/lib/roebe/yaml/size_of_countries.yml +197 -0
- data/lib/roebe/yaml/statistics/statistics.yml +17 -0
- data/lib/roebe/yaml/sternzeichen/sternzeichen.yml +16 -0
- data/lib/roebe/yaml/system/system.yml +80 -0
- data/lib/roebe/yaml/temperature_of_the_planets_in_our_solar_system/temperature_of_the_planets_in_our_solar_system.yml +22 -0
- data/lib/roebe/yaml/test/README.md +4 -0
- data/lib/roebe/yaml/test/umlaute.yml +2 -0
- data/lib/roebe/yaml/the_beginning_of_linux/the_beginning_of_linux.yml +29 -0
- data/lib/roebe/yaml/use_colours.yml +1 -0
- data/lib/roebe/yaml/world_capitals/world_capitals.yml +204 -0
- data/lib/roebe/yaml/world_geography_and_people/world_geography_and_people.yml +13 -0
- data/lib/roebe.rb +7 -0
- data/roebe.gemspec +104 -0
- data/test/hello_world/hello_world.rb +1 -0
- data/test/misc/README.md +2 -0
- data/test/misc/arity_example.rb +44 -0
- data/test/misc/display_the_shell_colours.rb +48 -0
- data/test/misc/fetch_a_specific_key_from_a_hash.rb +26 -0
- data/test/misc/fork_example.rb +15 -0
- data/test/misc/hello_world.rb +1 -0
- data/test/misc/heredoc_example.rb +9 -0
- data/test/misc/minimal_irc_bot/minimal_irc_bot.rb +33 -0
- data/test/misc/name_of_this_script.rb +12 -0
- data/test/misc/read_keypresses.rb +79 -0
- data/test/misc/readline/README.md +1 -0
- data/test/misc/readline/completion_for_a_static_list.rb +33 -0
- data/test/misc/simple_sigint_example.rb +51 -0
- data/test/misc/simple_user_input_via_stdin_or_Readline_example.rb +14 -0
- data/test/misc/tcp_socket_example.rb +28 -0
- data/test/misc/tracer.rb +39 -0
- data/test/misc/with_border.rb +22 -0
- data/test/testing_cat.rb +3 -0
- data/test/testing_class_configuration/testing_class_configuration.rb +81 -0
- data/test/testing_core_functionality_of_ruby/README.md +6 -0
- data/test/testing_core_functionality_of_ruby/file_test.rb +1 -0
- data/test/testing_core_functionality_of_ruby/verbose_file_copy.rb +5 -0
- data/test/testing_google_url_cleaner.rb +25 -0
- data/test/testing_http_status_codes.rb +13 -0
- data/test/testing_identical.rb +17 -0
- data/test/testing_move_file.rb +14 -0
- data/test/testing_permission_ascii_format.rb +23 -0
- data/test/testing_sql_paradise.rb +17 -0
- data/test/testing_the_roebe_shell.rb +31 -0
- data/test/testing_twentyfour_hours_notation.rb +37 -0
- data/test/testing_zenity.rb +26 -0
- metadata +2877 -0
@@ -0,0 +1,514 @@
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english('Virology') {
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pre {
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'
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ruby_favicon
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doc('pad2px mar1px') {
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# ========================================================================= #
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# === Receptors used by different viruses
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# ========================================================================= #
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h2 dot109?+
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'Receptors used by different viruses'
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div {
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e 'The following table should just show some examples of viruses
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using different receptors. It is not meant to be all-inclusive,
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but merely attempts to showcase some examples.'
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br
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table2('mars2em FS1_2em','','border-spacing: 8pt',
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'<b class="bigger">Name of the virus</b>','<b class="bigger">Receptor used by that virus</b>',
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'HIV-1','CD4 receptor (note that CCR5 or CXCR4 act as <b>co-receptors</b> here).',
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'Influenza','Sialic Acids',
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'Measles Virus','CD46 (note that CD150 is also a receptor for the measles virus)',
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'Herpes simplex virus','Heparan Sulfate',
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'Rhinovirus','ICAM-1 (interestingly about 10% of the rhinoviruses use the
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<b>VLDL receptor</b>)'
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)
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}
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# ========================================================================= #
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# === Images and Sketches of Viruses
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# ========================================================================= #
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div('pad0_5em bblack1') {
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h2 dot102?+
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'Images and Sketches of Viruses',
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'mart0_2em s0_5em'
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dimg 'science/viruses/ORTHOMYXOVIRIDAE.png',
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'mar8px marl2em pad5px bblack1_dotted'
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dimg 'science/viruses/ASTROVIRIDAE.png',
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'mar8px marl2em pad5px bblack1_dotted'
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}
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# ========================================================================= #
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# === The Influenza virus
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# ========================================================================= #
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h3 'The Influenza virus'
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p_default {
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e 'This virus has two important surface proteins:'
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br
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le '- NA'
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le '- HA'
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br
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e 'Furthermore this virus also contains the Matrix-Protein M2
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which is <b>not</b> glycosylated.'
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}
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# ========================================================================= #
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# === Adenovirus and Adeno-associated virus
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# ========================================================================= #
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h3 'Adenovirus and Adeno-associated virus'
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p_default {
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e 'The Adenovirus (latin name for gland) can be used as a
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vector. As vector it can accomodate about 8.5 kb DNA.'
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br
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e 'The Adenovirus genome codes for several proteins that
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begin with the letter "E", such as E1a,
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E1b, E2 and so forth. In this context, the letter
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"E" stands for <b>early</b>, aka early proteins, produced
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shortly after infection of the target cell.'
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br
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e 'The area between E1a and E1b can be deleted. This place
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can then be populated via a gene cassette.'
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br
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e 'Adeno-associated viruses (AAV) are different to Adenovirus.
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While both are small viruses, the AAV belongs to the genus
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<i>Dependoparvovirus</i>, which in turn belongs to the family
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Parvoviridae.'
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br
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e 'AAV are small, at only about 20 nm. They are also
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replication-defective, containing a linear ssDNA
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genome of approximately 4.8 kilobases (kb). This also
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limits their use as <b>vectors for gene therapy</b>.'
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br
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e 'In order to replicate, AAV depend on a helper-virus.
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This explains the secondary name given to them:
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<i>dependoviruses</i>. This helper-virus must co-infect
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the same cell infecteed by AAV.'
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}
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# ========================================================================= #
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# === The T4 phage
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# ========================================================================= #
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h3 'The T4 phage'
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p_default {
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e 'Interestingly enough the T4 phage contains
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introns. One such intron was found in the
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td-gene (in 1984), which encodes for
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the thymidylate-synthase.'
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}
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# ========================================================================= #
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# === The Herpes simplex virus
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# ========================================================================= #
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# http://localhost/programming/ruby/src/roebe/lib/roebe/www/virology/virology.cgi#herpes_simplex
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# ========================================================================= #
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h3 'The Herpes simplex Virus (HS Virus)',
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'',
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'herpes_simplex'
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p_default {
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e 'The Herpes simplex genome size is <a href="https://journals.asm.org/doi/10.1128/JVI.01723-14">
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152 kbp</a> in length.'
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br
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e 'This virus can trigger certain diseases, including the infamous
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build up of lesions.'
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e 'Herpes simplex can be distinguished into:'
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le 'Herpes labialis (with lesions, mostly caused by HSV-1)'
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le 'Herpes nasalis (in the area of the nose)'
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le 'Herpes genitalis (in the area of the genitalia)'
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le 'Herpes perianalis'
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le 'Herpes glutealis (in the area of the anus and
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perineum respektively the rear side of a person)'
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}
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# ========================================================================= #
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# === Poliovirus
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# ========================================================================= #
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# http://localhost/programming/ruby/src/roebe/lib/roebe/www/virology/virology.cgi#poliovirus
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# ========================================================================= #
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h3 'Poliovirus', id: 'poliovirus'
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p_default {
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e 'Humans are the only known natural hosts of poliovirus. This made it
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difficult to study transmission of the poliovirs. In the year
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<b>1990</b>, however, a transgenic mouse strain was engineered to
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express the human CD155 molecule. These mice were susceptible to
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infection, whereas the normal nontransgenic mice were not.'
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}
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# ========================================================================= #
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# === Archaeal viruses
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# ========================================================================= #
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h2 'Archaeal viruses'
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p_default {
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e 'Archaeal virus have a <b>unique release mechanism</b>:'
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br
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dimg 'science/viruses/UNIQUE_VIRAL_RELEASE_MECHANISM.png',
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'mars3em bblack1'
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embed_videos '
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https://www.youtube.com/watch?v=L8oHs7G_syI
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https://www.youtube.com/watch?v=Rpj0emEGShQ
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https://www.youtube.com/watch?v=0h5Jd7sgQWY
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https://www.youtube.com/watch?v=iOaAG9Kou2Y
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https://www.youtube.com/watch?v=kYf_Sl8W3qY
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https://www.youtube.com/watch?v=gGuVGuRX2Po'
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}
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div {
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h2 'Pseudoknots','martb1px'
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p_default {
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e '- Enzymatic activity'
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e '- Ribosomal frameshifting'
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}
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}
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# ================================================================= #
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# === News pertaining to Viruses
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# ================================================================= #
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h1 'News pertaining to Viruses'
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# ================================================================= #
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# === 06.05.2022
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#
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# "Das einem Menschen eingesetzte Schweineherz war mit einem Virus
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# infiziert."
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#
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# Gathered from:
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#
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# https://www.heise.de/hintergrund/Das-einem-Menschen-eingesetzte-Schweineherz-war-mit-einem-Virus-infiziert-7077044.html
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#
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# ================================================================= #
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div('mar0px BG_Black pad0_5em s2em BOLD') { datum '06.05.2022' }
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p_default {
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boldbr 'Das einem Menschen eingesetzte Schweineherz war
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mit einem Virus infiziert '
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br
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pre '
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Die erste Transplantation eines gentechnisch veränderten Tierorgans
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endete vorzeitig – möglicherweise aufgrund eines bekannten und
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vermeidbaren Risikos.
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Das Schweineherz, das einem US-amerikanischen Patienten Anfang
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dieses Jahres in einer bahnbrechenden Operation transplantiert
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wurde, war mit einem Schweinevirus infiziert. Der könnte das
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Experiment zum Scheitern gebracht und zwei Monate später zum
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Tod des Patienten beigetragen haben, sagen
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Transplantationsspezialisten.
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David Bennett Sr. war dem Tod nahe, als er im Januar ein
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genetisch verändertes Schweineherz in einer artübergreifenden
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Transplantation erhielt. Der Eingriff wurde als Erfolg
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gepriesen und er war es zunächst auch. Einige Tage, nachdem
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sein Herz durch ein Schweineherz ersetzt worden war, saß
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Bennett aufrecht im Bett. Sein neues Organ pumpte fantastisch
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und "funktionierte wie ein Rockstar", wie sein
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Transplantationschirurg Bartley Griffith von der
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University of Maryland School of Medicine sagte.
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Doch etwa 40 Tage später ging es dem 57-jährigen Patienten
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schlechter. Nach zwei Monaten starb er, im März 2022.
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In einer von der Universität im März herausgegebenen Erklärung
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sagte ein Sprecher, dass zum Zeitpunkt seines Todes "keine
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offensichtliche Ursache festgestellt werden konnte" und
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dass ein vollständiger Bericht noch ausstehe.
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<b>Diskussion um infiziertes Schweineherz</b>
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Nun hat MIT Technology Review erfahren, dass Bennetts
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Herz vom porcinen Cytomegalovirus befallen war, einer
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vermeidbaren Infektion, die verheerende Auswirkungen
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auf Transplantationen hat. Griffith berichtete von
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den verzweifelten Bemühungen, das Schweinevirus zu
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bekämpfen, während eines online gestreamten Webinars
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der American Society of Transplantation vom 20. April.
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Das Thema ist jetzt Gegenstand einer breiten Diskussion
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unter Fachleuten, die glauben, dass die Infektion
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möglicherweise zu Bennetts Tod beigetragen hat und
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ein möglicher Grund dafür ist, dass das Herz nicht
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länger geschlagen hat. "Wir beginnen zu verstehen,
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warum er gestorben ist", sagt Griffith. Der Transp
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lantationschirurg glaubt, dass das Virus "vielleicht
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der Auslöser war oder gewesen sein könnte, der die
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ganze Sache in Gang gesetzt hat."
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Der Eingriff in Maryland war ein wichtiger Test für
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die Xenotransplantation, also die Übertragung von
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Gewebe zwischen verschiedenen Tierarten. Da die
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für die Organspende gezüchteten Schweine jedoch
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virusfrei sein sollen, scheint das Experiment
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nun durch einen unbeabsichtigten Fehler gefährdet
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zu sein. Das Biotechnologieunternehmen Revivicor,
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das die Schweine gezüchtet und entwickelt hat,
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lehnte eine Stellungnahme ab und hat auch
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keine öffentliche Erklärung zu dem Virus abgegeben.
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"Es war überraschend. Das Schwein sollte eigentlich
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frei von allen Krankheitserregern sein, und dies
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ist ein bedeutender Erreger", sagt Mike Curtis,
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Geschäftsführer des Konkurrenzunternehmens
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eGenesis, das ebenfalls Schweine für Transplantationsorgane
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züchtet. "Hätte Mr. Bennett ohne das Virus überlebt? Wir
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wissen es nicht, aber die Infektion hat nicht geholfen.
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Sie hat wahrscheinlich zum Versagen beigetragen."
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Zehn veränderte Schweinegene
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Der Nachweis des Schweinevirus im Herzen von Bennett
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ist nicht unbedingt eine rein schlechte Nachricht
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für die Xenotransplantation. Wenn ein Schweinevirus
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eine Rolle spielte, könnte dies bedeuten, dass
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virenfrei transplantierte Schweineherzen viel
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länger halten könnten. Einige Chirurgen glauben,
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dass die neuesten gentechnisch veränderten Organe
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theoretisch jahrelang weiterschlagen könnten –
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und mit strengeren Verfahren sollte es möglich
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sein, das Virus herauszufiltern. "Wenn dies
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eine Infektion war, können wir sie in Zukunft
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wahrscheinlich verhindern", sagte Griffith
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während seiner Präsentation.
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Das größte Hindernis für Organtransplantationen bei
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Tieren ist das menschliche Immunsystem, das fremde
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Zellen in einem als Abstoßung bezeichneten Prozess
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heftig attackiert. Um Abstoßungsreaktionen zu
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vermeiden, haben Unternehmen Schweine gentechnisch
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verändert und ihnen einige Gene entfernt sowie
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andere hinzugefügt, um ihrem Gewebe ein
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Tarnkappenprofil zu verleihen, das es vor
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Immunangriffen versteckt. Bei dem in Maryland
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verwendeten Schwein hatte Revivicor, eine
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Tochtergesellschaft von United Therapeutics,
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dafür zehn Genveränderungen vorgenommen.
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Nach vielversprechenden Tests solcher Schweineorgane an Pavianen
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haben drei US-Transplantationsteams die ersten Studien am Menschen
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gestartet, die Ende 2021 beginnen sollen. Chirurgen der New York
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University und der University of Alabama haben hirntoten Menschen
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jeweils eine Schweineniere eingesetzt. Aber die University of
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Maryland ging noch einen Schritt weiter, als der Chirurg Griffith
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Anfang Januar ein Schweineherz in Bennetts Brust einpflanzte.'
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}
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# ================================================================= #
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# === 11.06.2002
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#
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# From:
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#
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# https://news.bbc.co.uk/1/hi/sci/tech/2122619.stm
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#
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# ================================================================= #
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div('mar0px BG_Black pad0_5em s2em BOLD') { datum '11.06.2002' }
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p_default {
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boldbr 'Scientists have assembled the first synthetic virus.'
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pre 'The US researchers built the infectious agent from scratch using the
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genome sequence for polio. Scientists are divided about whether a
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virus is alive. For those that think it is, then this synthetic
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artefact would constitute a simple form of life.
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Responding to criticisms that such research could lead to bioterrorists
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engineering new lethal viruses, the scientists behind the experiment
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said that only a few people had the knowledge to make it happen.
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To construct the virus, the researchers say they followed a recipe
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they downloaded from the internet and used gene sequences from a
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mail-order supplier.
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Having constructed the virus, which appears to be identical to
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its natural counterpart, the researchers, from the University of
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New York at Stony Brook, injected it into mice to demonstrate
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that it was active.
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The animals were paralysed and then died.
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"The reason we did it was to prove that it can be done and it now
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is a reality," said Dr Eckard Wimmer, leader of the biomedical
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research team and co-author of the study published in the journal
|
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Science.
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"This approach has been talked about, but people did not take
|
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it seriously," said Dr Wimmer.
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+
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"Now people have to take it seriously. Progress in biomedical
|
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+
research has its benefits and it has its down side. There is
|
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a danger inherent to progress in sciences.
|
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This is a new reality, a new consideration."
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+
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According to researcher Jeronimo Cello, the polio virus
|
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assembled in the laboratory is one of the simplest known
|
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+
viruses. "It was very easy to do," he said.
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+
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The more dangerous smallpox virus would be complex and
|
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+
difficult to assemble, but Cello says, "it would probably
|
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in the future be possible".
|
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Dr Wimmer added: "The world had better be prepared."
|
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+
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Smallpox has been eradicated in the wild, but specimens
|
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+
are stored in the United States and in Russia.
|
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+
|
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Dr Wimmer said assembling the polio virus showed that
|
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|
+
eradicating a virus in the wild might not mean it was
|
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+
gone forever because biochemists could now reconstruct
|
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+
those viruses from blueprints.'
|
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}
|
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+
|
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paragraph_content = <<-EOF
|
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+
Following last year's terrorist and anthrax-by-mail
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+
attacks, US officials became concerned about the
|
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+
threat of smallpox and arranged for the manufacture
|
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+
of enough vaccine to protect the US population.
|
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+
|
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Dr CJ Peters, director for the Center for Biodefense
|
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+
at the University of Texas Medical Center at Galveston,
|
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+
said experts had known for years that it was theoretically
|
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|
+
possible to assemble a virus in the lab.
|
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+
|
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+
"We have known this could be done. We have known it
|
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|
+
was just a matter of time before it was done", he said.
|
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+
|
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+
Dr Peters said he was concerned that publicity about
|
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|
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a synthesized virus might lead some people to believe
|
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+
that there is nothing that can be done about
|
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+
bioterrorism - which is not the case.
|
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+
|
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+
He added that it was possible that viruses like
|
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Ebola could be assembled in laboratories, but there
|
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+
were only a few people in the world with that skill.
|
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+
|
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Polio is on the brink of being eradicated worldwide
|
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|
+
and there are plans to stop inoculations against the
|
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|
+
disease after it disappears from nature.
|
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+
|
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+
Dr Wimmer said that this policy should be reconsidered.
|
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|
+
Stopping vaccination could lead to a generation of
|
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|
+
people highly susceptible to polio, enhancing its
|
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|
+
appeal as a weapon.
|
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|
+
|
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|
+
The World Health Organization is planning to stockpile
|
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|
+
vaccines against a return of polio and Dr Wimmer
|
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|
+
said that policy should be followed everywhere.
|
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|
+
EOF
|
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|
+
p {
|
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|
+
e paragraph_content
|
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|
+
}
|
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|
+
# ========================================================================= #
|
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|
+
# === Slogans Tag
|
401
|
+
# ========================================================================= #
|
402
|
+
h1 dot108?+
|
403
|
+
'Slogans','martb1px'
|
404
|
+
p_default('mars1em pad1_5em s2em mart3em fancy_shadow') {
|
405
|
+
e "→ Bacteriophages are very close to <b>'naked, genetic
|
406
|
+
systems'</b> (Luria 1953)."
|
407
|
+
e "→ Phage are nature's genetic engineers."
|
408
|
+
e '→ Viren können Zellen in eine S-Phase überführen ("stoßen").'
|
409
|
+
e '→ Viruses can "hijack" host cells.'
|
410
|
+
e '→ Die spanische Grippe war so tödlich weil viele Menschen unterernährt
|
411
|
+
waren.'
|
412
|
+
e '→ Es gibt Perioden zwischen Virus-Epidemien.'
|
413
|
+
e '→ Tiere können Reservoirs für Viren darstellen.'
|
414
|
+
e '→ Infection of poliovirus in infancy gives life-long protection.'
|
415
|
+
e '→ The length of DNA that can be incorporated into a virus is
|
416
|
+
limited by the structure of the headshell.'
|
417
|
+
e '→ A reassortant ist a hybrid virus that was generated by combining
|
418
|
+
RNA gene segments from at the least two different viruses.'
|
419
|
+
e '→ Vaccines mimic a viral infection without causing disease.'
|
420
|
+
e '→ Polyomavirus middle T antigen mimics an activated growth factor
|
421
|
+
receptor and thus is mitogenic (i.e. it can induce mitosis).'
|
422
|
+
e '→ The Dengue virus is transmitted by <b>Aedes aegypti</b>, a mosquito.'
|
423
|
+
e '→ Attenuation of the poliovirus leads to loss of neurovirulence in
|
424
|
+
humans, but the attenuated virus (in the poliovirus vaccine) can still
|
425
|
+
replicate in the intestine, and thus generate immunity.'
|
426
|
+
e '→ Icosahedral symmetry require lesser amounts of energy, compared
|
427
|
+
to other structures, and so this structure is evolutionarily
|
428
|
+
favored among virions.'
|
429
|
+
e '→ Reverse transcription ultimately means to create DNA from
|
430
|
+
an RNA template.'
|
431
|
+
e '→ All helical animal viruses are enveloped.'
|
432
|
+
e '→ The taxa used for classifying viruses are order, family,
|
433
|
+
genus, and species.'
|
434
|
+
e '→ Because they are not alive, viruses are not categorized within
|
435
|
+
the same taxonomical tree as living organisms.'
|
436
|
+
e '→ The goal of vaccination is to safely pre-expose our immune system
|
437
|
+
to a small, harmless dose of all or a piece of a pathogen so that,
|
438
|
+
if we encounter the actual pathogen in the future, our immune
|
439
|
+
system is already prepared to fight it and prevent disease.'
|
440
|
+
e '→ Viruses take over the metabolic systems of infected cells
|
441
|
+
and turn them into vessels for producing more viruses.'
|
442
|
+
e '→ The smallest viral genomes contains only three genes.' # Taken from Brock, "Microbiology".
|
443
|
+
e '→ Viruses are as diverse as the cells they infect.'
|
444
|
+
e '→ The term "fitness landscape" in Virology means that each
|
445
|
+
sequence of a RNA Virus (or for any other combination of
|
446
|
+
sequences) has a reproduction rate, which is simply
|
447
|
+
another term for "fitness".'
|
448
|
+
e "→ 15-20% of world's cancers are caused by virsues or other
|
449
|
+
infectious agents."
|
450
|
+
e '→ Eine Herausforderung in der Virologie besteht darin geeignete
|
451
|
+
Kultursysteme für ein spezifisches Virus zu suchen und zu finden.'
|
452
|
+
e '→ Vectors can act as carriers, delivering DNA payloads to
|
453
|
+
defective cells.'
|
454
|
+
e '→ The idea behind error threshold postulates that too many
|
455
|
+
mutations in the viral genome lead to a non-viable virus.'
|
456
|
+
e '→ Phages reprogramm bacteria to replicate and yield more
|
457
|
+
phages.'
|
458
|
+
e '→ Recombination events sometimes occurr when phages infect
|
459
|
+
bacteria.'
|
460
|
+
e '→ Bacteriophages behave like higher organisms with regard
|
461
|
+
to heritable variation.'
|
462
|
+
e '→ Restriction enzymes can guillotine the DNA strands of otherwise
|
463
|
+
lethal bacteriophages at specific positions to counter these viral
|
464
|
+
attacks.'
|
465
|
+
e '→ RNAi (<b>RNA interference</b>) is <b>involved in virus defense</b>.'
|
466
|
+
e '→ A virus is essentially DNA or RNA wrapped in a protein coating.'
|
467
|
+
e '→ Viruses and phages can be called genetic engineering as done
|
468
|
+
by nature.'
|
469
|
+
e '→ Viruses must conform to the limitations of the host cell in order
|
470
|
+
to replicate.'
|
471
|
+
e '→ In herpes and several other diseases caused by a virus, a virus
|
472
|
+
splices its genes into the DNA of a host cell.'
|
473
|
+
e '→ Already back in 2002, more than 900 different viral genomes
|
474
|
+
have been sequenced.'
|
475
|
+
e '→ Viruses that infect eukaryotic cells have attachment protein that
|
476
|
+
must adsorb to a cell surface receptor on the target cell.'
|
477
|
+
e '→ The rhinovirus binds to a protein known as intercellular adhesion
|
478
|
+
molecule 1 (ICAM-1). ICAM-1 is normally involved in the attachment of
|
479
|
+
one cell to another.'
|
480
|
+
e '→ Virus attachment proteins are the target of many antiviral drugs in
|
481
|
+
use and in development.'
|
482
|
+
e '→ Attachment involves opposing electrostatic forces on the virus
|
483
|
+
attachment protein and the cell surface receptor.'
|
484
|
+
e '→ The rhinovirus may serve as an excellent example how different
|
485
|
+
strains of the same virus can take advantage of different cell
|
486
|
+
surface receptors for attachment.'
|
487
|
+
e '→ Although most viruses may employ clathrin or caveolin-mediated
|
488
|
+
entry into eukaryotic cells, some other viruses undergo
|
489
|
+
receptor-mediated endocytosis that is independent of both
|
490
|
+
clathrin and caveolin.'
|
491
|
+
e '→ If purified components from the TMV are placed in an adequate
|
492
|
+
solution and we wait for 24 hours, then we can observe
|
493
|
+
reassembly into functional viruses. The process <i>in-vivo</i>
|
494
|
+
is much faster, though.'
|
495
|
+
e '→ Viruses even invade our genomes.'
|
496
|
+
e '→ Viruses can rightfully be called <b>invading DNA</b>.'
|
497
|
+
e '→ <b>Retroviruses</b> do what retroviruses can do best: insert
|
498
|
+
their genes into the DNA of the host.'
|
499
|
+
e '→ Replikation nach dem rolling-circle-Mechanismus, wie zum
|
500
|
+
Beispiel vom λ Phage, erinnert an ein Fließband.'
|
501
|
+
}
|
502
|
+
# ========================================================================= #
|
503
|
+
# === Link Tag
|
504
|
+
# ========================================================================= #
|
505
|
+
h2 'Links'
|
506
|
+
div('mar0px pad0px mars1em') {
|
507
|
+
p('s0_5em') {
|
508
|
+
abr_self :sitemap
|
509
|
+
abr_self :local_genetics
|
510
|
+
abr_self :local_cellbiology
|
511
|
+
abr_self :local_microbiology
|
512
|
+
}
|
513
|
+
}
|
514
|
+
}}
|
@@ -0,0 +1,56 @@
|
|
1
|
+
#!/usr/bin/ruby -w
|
2
|
+
# Encoding: UTF-8
|
3
|
+
# frozen_string_literal: true
|
4
|
+
# =========================================================================== #
|
5
|
+
# http://localhost/programming/ruby/src/roebe/lib/roebe/www/virology/virology.sinatra
|
6
|
+
# =========================================================================== #
|
7
|
+
require 'cyberweb/and_sinatra_base.rb'
|
8
|
+
|
9
|
+
module Roebe
|
10
|
+
|
11
|
+
class SinatraVirology < ::Sinatra::Base # === Roebe::SinatraVirology
|
12
|
+
|
13
|
+
# ========================================================================= #
|
14
|
+
# === USE_THIS_PORT
|
15
|
+
# ========================================================================= #
|
16
|
+
if ENV['SINATRA_PORT']
|
17
|
+
USE_THIS_PORT = ENV['SINATRA_PORT'].to_s.dup
|
18
|
+
else
|
19
|
+
USE_THIS_PORT = '4567'
|
20
|
+
end
|
21
|
+
|
22
|
+
set :port, USE_THIS_PORT
|
23
|
+
|
24
|
+
# ========================================================================= #
|
25
|
+
# === initialize
|
26
|
+
# ========================================================================= #
|
27
|
+
def initialize
|
28
|
+
super()
|
29
|
+
target = "http://localhost:#{USE_THIS_PORT}/"
|
30
|
+
Cyberweb.try_to_open_this_URL_via_the_browser(target, USE_THIS_PORT)
|
31
|
+
end
|
32
|
+
|
33
|
+
# ========================================================================= #
|
34
|
+
# === /
|
35
|
+
#
|
36
|
+
# Usage Example:
|
37
|
+
#
|
38
|
+
# http://localhost:4567/
|
39
|
+
#
|
40
|
+
# ========================================================================= #
|
41
|
+
get('/'){
|
42
|
+
return Cyberweb::WebObject.evaluate_from_the_same_named_file_then_serve(:do_not_display_anything)
|
43
|
+
}
|
44
|
+
|
45
|
+
# ========================================================================= #
|
46
|
+
# === Roebe::English.start_sinatra_interface
|
47
|
+
# ========================================================================= #
|
48
|
+
def self.start_sinatra_interface
|
49
|
+
::Roebe::SinatraVirology.run!
|
50
|
+
end
|
51
|
+
|
52
|
+
end; end
|
53
|
+
|
54
|
+
if __FILE__ == $PROGRAM_NAME
|
55
|
+
Roebe::SinatraVirology.start_sinatra_interface
|
56
|
+
end
|
@@ -0,0 +1,7 @@
|
|
1
|
+
#!/usr/bin/ruby -w
|
2
|
+
# Encoding: UTF-8
|
3
|
+
# frozen_string_literal: true
|
4
|
+
# =========================================================================== #
|
5
|
+
# http://localhost/DATA/PROGRAMMING_LANGUAGES/RUBY/src/roebe/lib/roebe/www/virtual_reality/virtual_reality.cgi
|
6
|
+
# =========================================================================== #
|
7
|
+
require 'cyberweb/evaluate_from_the_same_named_file_then_serve'
|