rbbt-phgx 0.1.0 → 0.2.0

data/share/Cancer/cancer_genes.tsv

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+Symbol	Name	GeneID	Chr	Chr Band	Cancer Somatic Mut	Cancer Germline Mut	Tumour Types  (Somatic Mutations)	Tumour Types (Germline Mutations)	Cancer Syndrome	Tissue Type	Cancer Molecular Genetics	Mutation Type 	Translocation Partner	Other Germline Mut	Other Syndrome/Disease
+ABL1	v-abl Abelson murine leukemia viral oncogene homolog 1	25	9	9q34.1 	yes		CML, ALL, T-ALL			L	Dom	T, Mis	BCR, ETV6, NUP214		
+ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	27	1	1q24-q25 	yes		AML			L	Dom	T	ETV6		
+ACSL3	acyl-CoA synthetase long-chain family member 3	2181	2	2q36	yes		prostate			E	Dom	T	ETV1		
+AF15Q14	AF15q14 protein	57082	15	15q14	yes		AML			L	Dom	T	MLL		
+AF1Q	ALL1-fused gene from chromosome 1q	10962	1	1q21 	yes		ALL			L	Dom	T	MLL		
+AF3p21	SH3 protein interacting with Nck, 90 kDa (ALL1 fused gene from 3p21)	51517	3	3p21	yes		ALL			L	Dom	T	MLL		
+AF5q31	ALL1 fused gene from 5q31	27125	5	5q31 	yes		ALL			L	Dom	T	MLL		
+AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	10142  	7	7q21-q22	yes		papillary thyroid			E	Dom	T	BRAF		
+AKT1	v-akt murine thymoma viral oncogene homolog 1	207	14	14q32.32	yes		breast, colorectal, ovarian, NSCLC			E	Dom	Mis			
+AKT2	v-akt murine thymoma viral oncogene homolog 2	208	19	19q13.1-q13.2 	yes		ovarian, pancreatic 			E	Dom	A			
+ALK	anaplastic lymphoma kinase (Ki-1)	238	2	2p23 	yes	yes	ALCL, NSCLC, Neuroblastoma	neuroblastoma	Familial neuroblastoma	L, E, M	Dom	T, Mis, A	NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4		
+ALO17	KIAA1618 protein	57714	17	17q25.3	yes		ALCL			L	Dom	T	ALK		
+APC	adenomatous polyposis of the colon gene	324	5	5q21	yes	yes	colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS	colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS	Adenomatous polyposis coli; Turcot syndrome	E, M, O	Rec	D, Mis, N, F, S			
+ARHGEF12	RHO guanine nucleotide exchange factor (GEF) 12 (LARG)	23365	11	11q23.3 	yes		AML			L	Dom	T	MLL		
+ARHH	RAS homolog gene family, member H (TTF)	399	4	4p13 	yes		NHL			L	Dom	T	BCL6		
+ARNT	aryl hydrocarbon receptor nuclear translocator	405	1	1q21 	yes		AML			L	Dom	T	ETV6		
+ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1	79058	17	17q25	yes		alveolar soft part sarcoma			M	Dom	T	TFE3		
+ASXL1	additional sex combs like 1	171023	20	20q11.1	yes		MDS, CMML			L	Rec	F, N, Mis			
+ATF1	activating transcription factor 1	466	12	12q13 	yes		malignant melanoma of soft parts , angiomatoid fibrous histiocytoma 			E, M	Dom	T	EWSR1, FUS		
+ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	471	2	2q35	yes		ALCL			L	Dom	T	ALK		
+ATM	ataxia telangiectasia mutated	472	11	11q22.3 	yes	yes	T-PLL	leukemia, lymphoma, medulloblastoma, glioma	Ataxia-telangiectasia	L, O	Rec	D, Mis, N, F, S			
+BCL10	B-cell CLL/lymphoma 10	8915	1	1p22	yes		MALT 			L	Dom	T	IGH@		
+BCL11A	B-cell CLL/lymphoma 11A	53335	2	2p13 	yes		B-CLL			L	Dom	T	IGH@		
+BCL11B	B-cell CLL/lymphoma 11B  (CTIP2)	64919	14	14q32.1	yes		T-ALL			L	Dom	T	TLX3		
+BCL2	B-cell CLL/lymphoma 2	596	18	18q21.3 	yes		NHL, CLL			L	Dom	T	IGH@		
+BCL3	B-cell CLL/lymphoma 3	602	19	19q13 	yes		CLL 			L	Dom	T	IGH@		
+BCL5	B-cell CLL/lymphoma 5	603	17	17q22 	yes		CLL			L	Dom	T	MYC		
+BCL6	B-cell CLL/lymphoma 6	604	3	3q27 	yes		NHL, CLL			L	Dom	T, Mis	IG loci, ZNFN1A1, LCP1, PIM1, TFRC, MHC2TA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3		
+BCL7A	B-cell CLL/lymphoma 7A	605	12	12q24.1	yes		BNHL			L	Dom	T	MYC		
+BCL9	B-cell CLL/lymphoma 9	607	1	1q21	yes		B-ALL			L	Dom	T	IGH@, IGL@		
+BCR	breakpoint cluster region	613	22	22q11.21 	yes		CML, ALL, AML			L	Dom	T	ABL1,  FGFR1, JAK2 		
+BHD	folliculin, Birt-Hogg-Dube syndrome	201163	17	17p11.2		yes		renal, fibrofolliculomas, trichodiscomas 	Birt-Hogg-Dube syndrome	E, M	Rec?	Mis. N, F			
+BIRC3	baculoviral IAP repeat-containing 3	330	11	11q22-q23	yes		MALT			L	Dom	T	MALT1		
+BLM	Bloom Syndrome	641	15	15q26.1		yes		leukemia, lymphoma, skin squamous cell , other cancers	Bloom Syndrome	L, E	Rec	Mis, N, F			
+BMPR1A	bone morphogenetic protein receptor, type IA	657	10	 10q22.3 		yes		gastrointestinal polyps	Juvenile polyposis	E	Rec	Mis, N, F			
+BRAF	v-raf murine sarcoma viral oncogene homolog B1	673	7	7q34	yes		melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma			E	Dom	Mis, T, O	AKAP9, KIAA1549	yes	Cardio-facio-cutaneous syndrome
+BRCA1	familial breast/ovarian cancer gene 1	672	17	17q21	yes	yes	ovarian	breast, ovarian	Hereditary breast/ovarian cancer	E	Rec	D, Mis, N, F, S			
+BRCA2	familial breast/ovarian cancer gene 2	675	13	13q12	yes	yes	breast, ovarian, pancreatic	breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)	Hereditary breast/ovarian cancer	L, E	Rec	D, Mis, N, F, S			
+BRD3	bromodomain containing 3	8019	9	9q34	yes		lethal midline carcinoma of young people			E	Dom	T	NUT		
+BRD4	bromodomain containing 4	23476	19	19p13.1	yes		lethal midline carcinoma of young people			E	Dom	T	NUT		
+BRIP1	BRCA1 interacting protein C-terminal helicase 1	83990	17	17q22		yes		AML, leukemia, breast	Fanconi anaemia J, breast cancer susceptiblity	L, E	Rec	F, N, Mis			
+BTG1	B-cell translocation gene 1, anti-proliferative	694	12	12q22	yes		BCLL			L	Dom	T	MYC		
+BUB1B	BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)	701	15	15q15		yes		rhabdomyosarcoma	Mosaic variegated aneuploidy	M	Rec	Mis, N, F, S			
+C12orf9	chromosome 12 open reading frame 9	93669	12	12q14.3	yes		lipoma			M	Dom	T	LPP		
+C15orf21	chromosome 15 open reading frame 21	283651	15	15q21.1	yes		prostate			E	Dom	T	ETV1		
+CANT1	calcium activated nucleotidase 1	124583	17	17q25	yes		prostate			E	Dom	T	ETV4		
+CARD11	caspase recruitment domain family, member 11	84433	7	7p22 	yes		DLBL			L	Dom	Mis			
+CARS	cysteinyl-tRNA synthetase	833	11	11p15.5	yes		ALCL			L	Dom	T	ALK		
+CBFA2T1	core-binding factor, runt domain, alpha subunit 2;translocated to, 1  (ETO)	862	8	8q22 	yes		AML			L	Dom	T	MLL, RUNX1		
+CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3 (MTG-16)	863	16	16q24	yes		AML			L	Dom	T	RUNX1		
+CBFB	core-binding factor, beta subunit	865	16	16q22 	yes		AML			L	Dom	T	MYH11		
+CBL 	Cas-Br-M (murine) ecotropic retroviral transforming	867	11	11q23.3	yes		AML, JMML, MDS			L	Dom, Rec	T, Mis S, O	MLL		
+CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	868	3	3q13.11	yes		AML			L	Rec	Mis S			
+CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	23624	19	19q13.2	yes		AML			L	Rec	M			
+CCND1	cyclin D1	595	11	11q13 	yes		CLL, B-ALL, breast			L, E	Dom	T	IGH@, FSTL3		
+CCND2	cyclin D2	894	12	12p13	yes		NHL,CLL			L	Dom	T	IGL@		
+CCND3	cyclin D3	896	6	6p21	yes		MM			L	Dom	T	IGH@		
+CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	972	5	5q32	yes		NSCLC			E	Dom	T	ROS1		
+CD79A	CD79a molecule, immunoglobulin-associated alpha	973	19	19q13.2	yes		DLBCL			L	Dom	O, S			
+CD79B	CD79b molecule, immunoglobulin-associated beta	974	17	17q23	yes		DLBCL			L	Dom	Mis, O			
+CDH1	cadherin 1, type 1, E-cadherin (epithelial) (ECAD)	999	16	16q22.1 	yes	yes	lobular breast, gastric	gastric	Familial gastric carcinoma	E	Rec	Mis, N, F, S			
+CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	1009	16	16q22.1 	yes		aneurysmal bone cysts			M	Dom	T	USP6		
+CDK4	cyclin-dependent kinase 4	1019	12	12q14 		yes		melanoma 	Familial malignant melanoma	E	Dom	Mis			
+CDK6	cyclin-dependent kinase 6	1021	7	7q21-q22	yes		ALL			L	Dom	T	MLLT10		
+CDKN2A -p16(INK4a) 	cyclin-dependent kinase inhibitor 2A (p16(INK4a)) gene	1029	9	9p21 	yes	yes	melanoma, multiple other tumour types	melanoma, pancreatic	Familial malignant melanoma	L, E, M, O	Rec	D, Mis, N, F, S			
+CDKN2A- p14ARF	cyclin-dependent kinase inhibitor 2A--  p14ARF protein	1029	9	9p21 	yes	yes	melanoma, multiple other tumour types	melanoma, pancreatic	Familial malignant melanoma	L, E, M, O	Rec	D, S			
+CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	1031	1	1p32	yes		glioma, MM			O, L	Rec	D			
+CDX2	caudal type homeo box transcription factor 2	1045	13	13q12.3 	yes		AML			L	Dom	T	ETV6		
+CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	1050	19	19q13.1	yes		AML, MDS			L	Dom	Mis, N, F			
+CEP1	centrosomal protein 1	11064	9	9q33	yes		MPD, NHL			L	Dom	T	FGFR1		
+CHCHD7	coiled-coil-helix-coiled-coil-helix domain containing 7	79145	8	8q11.2	yes		salivary adenoma			E	Dom	T	PLAG1		
+CHEK2	CHK2 checkpoint homolog (S. pombe)	11200	22	22q12.1		yes		breast 	familial breast cancer	E	Rec	F			
+CHIC2	cysteine-rich hydrophobic domain 2	26511	4	4q11-q12	yes		AML			L	Dom	T	ETV6		
+CHN1	chimerin (chimaerin) 1	1123	2	2q31-q32.1 	yes		extraskeletal myxoid chondrosarcoma			M	Dom	T	TAF15		
+CIC	capicua homolog (Drosophila)	23152	19	19q13.2	yes		soft tissue sarcoma			M	Dom	T	DUX4		
+CLTC	clathrin, heavy polypeptide (Hc)	1213	17	17q11-qter	yes		ALCL, renal 			L	Dom	T	ALK, TFE3		
+CLTCL1	clathrin, heavy polypeptide-like 1	8218	22	22q11.21	yes		ALCL			L	Dom	T	?		
+CMKOR1	chemokine orphan receptor 1	57007	2	2q37.3	yes		lipoma			M	Dom	T	HMGA2		
+COL1A1	collagen, type I, alpha 1	1277	17	17q21.31-q22	yes		dermatofibrosarcoma protuberans, aneurysmal bone cyst 			M	Dom	T	PDGFB, USP6	yes	Osteogenesis imperfecta
+COPEB	core promoter element binding protein (KLF6)	1316	10	10p15	yes		prostate, glioma			E, O	Rec	Mis, N 			
+COX6C	cytochrome c oxidase subunit VIc	1345	8	8q22-q23 	yes		uterine leiomyoma			M	Dom	T	HMGA2		
+CREB1	cAMP responsive element binding protein 1	1385	2	2q34	yes		clear cell sarcoma, angiomatoid fibrous histiocytoma			M	Dom	T	EWSR1		
+CREB3L2	cAMP responsive element binding protein 3-like 2	64764	7	7q34	yes		fibromyxoid sarcoma			M	Dom	T	FUS		
+CREBBP	CREB binding protein (CBP)	1387	16	16p13.3 	yes		AL, AML			L	Dom	T	MLL, MORF, RUNXBP2	yes	Rubinstein-Taybi syndrome
+CRLF2	cytokine receptor-like factor 2	64109	X,Y	Xp22.3; Yp11.3	yes		B-ALL, Downs associated ALL			L	Dom	Mis, T	P2RY8, IGH@		
+CRTC3	CREB regulated transcription coactivator 3	64784	15	15q26.1	yes		salivary gland mucoepidermoid			E	Dom	T	MAML2		
+CTNNB1	catenin (cadherin-associated protein), beta 1	1499	3	3p22-p21.3 	yes		colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma			E, M, O	Dom	H, Mis, T	PLAG1		
+CYLD	familial cylindromatosis gene	1540	16	16q12-q13 	yes	yes	cylindroma	cylindroma	Familial cylindromatosis	E	Rec	Mis, N, F, S			
+D10S170	DNA segment on chromosome 10 (unique) 170, H4 gene (PTC1)	8030	10	10q21	yes		papillary thyroid, CML			E	Dom	T	RET, PDGFRB		
+DDB2	damage-specific DNA binding protein 2	1643	11	11p12		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (E)	E	Rec	Mis, N			
+DDIT3	DNA-damage-inducible transcript 3	1649	12	12q13.1-q13.2 	yes		liposarcoma			M	Dom	T	FUS		
+DDX10	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	1662	11	11q22-q23 	yes		AML*			L	Dom	T	NUP98		
+DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	1655	17	17q21	yes		prostate			E	Dom	T	ETV4		
+DDX6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	1656	11	11q23.3	yes		B-NHL			L	Dom	T	IGH@		
+DEK	DEK oncogene (DNA binding)	7913	6	6p23	yes		AML			L	Dom	T	NUP214		
+DICER1	dicer 1, ribonuclease type III 	23405	14	14q32.13		yes		pleuropulmonary blastoma	Familial Pleuropulmonary Blastoma	E	Rec	Mis F, N			
+DUX4	double homeobox, 4	22947	4	4q35	yes		soft tissue sarcoma			M	Dom	T	CIC		
+EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	1956	7	7p12.3-p12.1 	yes	yes	glioma, NSCLC	NSCLC	Familial lung cancer	E, O	Dom	A, O, Mis			
+EIF4A2	eukaryotic translation initiation factor 4A, isoform 2	1974	3	3q27.3	yes		NHL			L	Dom	T	BCL6		
+ELF4	E74-like factor 4 (ets domain transcription factor)	2000	X	Xq26	yes		AML			L	Dom	T	ERG		
+ELK4	ELK4, ETS-domain protein (SRF accessory protein 1)	2005	1	1q32	yes		prostate			E	Dom	T	SLC45A3		
+ELKS	ELKS protein	23085	12	12p13.3	yes		papillary thyroid			E	Dom	T	RET		
+ELL	ELL gene (11-19 lysine-rich leukemia gene)	8178	19	19p13.1	yes		AL			L	Dom	T	MLL		
+ELN	elastin	2006	7	7q11.23	yes		B-ALL			L	Dom	T	PAX5	yes	Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome
+EML4	echinoderm microtubule associated protein like 4	27436	2	2p21	yes		NSCLC			E	Dom	T	ALK		
+EP300	300 kd E1A-Binding protein gene	2033	22	22q13 	yes		colorectal, breast, pancreatic, AML			L, E	Rec	T	MLL, RUNXBP2		
+EPS15	epidermal growth factor receptor pathway substrate 15 (AF1p)	2060	1	1p32 	yes		ALL			L	Dom	T	MLL		
+ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	2064	17	17q21.1 	yes		breast, ovarian, other tumour types, NSCLC, gastric			E	Dom	A, Mis, O			
+ERCC2	excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)	2068	19	19q13.2-q13.3		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (D)	E	Rec	Mis, N, F, S			
+ERCC3	excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing)	2071	2	2q21		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (B)	E	Rec	Mis, S			
+ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4	2072	16	16p13.3-p13.13		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (F)	E	Rec	Mis, N, F			
+ERCC5	excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G (Cockayne syndrome))	2073	13	13q33		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (G)	E	Rec	Mis, N, F			
+ERG 	v-ets erythroblastosis virus E26 oncogene like (avian)	2078	21	21q22.3	yes		Ewing sarcoma, prostate, AML			M, E, L	Dom	T	EWSR1, TMPRSS2, ELF4, FUS, HERPUD1		
+ETV1	ets variant gene 1	2115	7	 7p22	yes		Ewing sarcoma, prostate			M, E	Dom	T	EWSR1, TMPRSS2, SLC45A3, C15orf21, HNRNPA2B1. ACSL3		
+ETV4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	2118	17	17q21	yes		Ewing sarcoma, Prostate carcinoma			M, E	Dom	T	EWSR1, TMPRSS2, DDX5, KLK2, CANT1		
+ETV5	ets variant gene 5	2119	3	3q28 	yes		Prostate 			E	Dom	T	TMPRSS2, SCL45A3		
+ETV6	ets variant gene 6 (TEL oncogene)	2120	12	12p13 	yes		congenital fibrosarcoma, multiple leukemia and lymphoma,  secretory breast, MDS, ALL			L, E, M	Dom	T	NTRK3, RUNX1, PDGFRB, ABL1, MN1, ABL2, FACL6, CHIC2, ARNT, JAK2, EVI1, CDX2, STL, HLXB9, MDS2, PER1, SYK, TTL, FGFR3, PAX5		
+EVI1	ecotropic viral integration site 1	2122	3	3q26 	yes		AML, CML			L	Dom	T	RUNX1, ETV6, PRDM16, RPN1		
+EWSR1	Ewing sarcoma breakpoint region 1 (EWS) 	2130	22	22q12 	yes		Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma			L, M	Dom	T	FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1		
+EXT1	multiple exostoses type 1 gene	2131	8	8q24.11-q24.13 		yes		exostoses, osteosarcoma	Multiple Exostoses Type 1	M	Rec	Mis, N, F, S			
+EXT2	multiple exostoses type 2 gene	2132	11	11p12-p11		yes		exostoses, osteosarcoma	Multiple Exostoses Type 2	M	Rec	Mis, N, F, S			
+EZH2	enhancer of zeste homolog 2	2146	7	7q35-q36	yes		DLBCL			L	Rec?	Mis			
+FACL6	fatty-acid-coenzyme A ligase, long-chain 6	23305	5	5q31 	yes		AML, AEL			L	Dom	T	ETV6		
+FANCA	Fanconi anemia, complementation group A	2175	16	16q24.3		yes		AML, leukemia	Fanconi anaemia A 	L	Rec	D, Mis, N, F, S			
+FANCC	Fanconi anemia, complementation group C	2176	9	9q22.3		yes		AML, leukemia	Fanconi anaemia C	L	Rec	D, Mis, N, F, S			
+FANCD2	Fanconi anemia, complementation group D2	2177	3	3p26		yes		AML, leukemia	Fanconi anaemia D2	L	Rec	D, Mis, N, F			
+FANCE	Fanconi anemia, complementation group E	2178	6	6p21-p22		yes		AML, leukemia	Fanconi anaemia E	L	Rec	N, F, S			
+FANCF	Fanconi anemia, complementation group F	2188	11	11p15		yes		AML, leukemia	Fanconi anaemia F	L	Rec	N, F			
+FANCG	Fanconi anemia, complementation group G	2189	9	9p13		yes		AML, leukemia	Fanconi anaemia G	L	Rec	Mis, N, F, S			
+FBXW7	F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)	55294	4	4q31.3	yes		colorectal, endometrial, T-ALL			E, L	Rec	Mis, N, D, F			
+FCGR2B	Fc fragment of IgG, low affinity IIb, receptor for (CD32)	2213	1	1q23	yes		ALL			L	Dom	T	?		
+FEV	FEV protein - (HSRNAFEV)	54738	2	2q36	yes		Ewing sarcoma			M	Dom	T	EWSR1,  FUS		
+FGFR1	fibroblast growth factor receptor 1 	2260	8	8p11.2-p11.1 	yes		MPD, NHL			L	Dom	T	BCR, FOP, ZNF198, CEP1	yes	Pfeiffer syndrome, Kallman syndrome
+FGFR1OP	FGFR1 oncogene partner (FOP)	11116	6	6q27	yes		MPD, NHL			L	Dom	T	FGFR1		
+FGFR2	fibroblast growth factor receptor 2 	2263	10	10q26 	yes		gastric. NSCLC, endometrial			E	Dom	Mis		yes	Crouzon, Pfeiffer, and Apert syndromes
+FGFR3	fibroblast growth factor receptor 3	2261	4	4p16.3 	yes		bladder, MM, T-cell lymphoma			L, E	Dom	Mis, T	IGH@, ETV6	yes	Hypochondroplasia, Thanatophoric dysplasia
+FH	fumarate hydratase	2271	1	1q42.1 		yes		lieomyomatosis, renal	hereditary leiomyomatosis and renal cell cancer	E, M	Rec	Mis, N, F			
+FIP1L1	FIP1 like 1 (S. cerevisiae)	81608	4	4q12	yes		idiopathic hypereosinophilic syndrome			L	Dom	T	PDGFRA		
+FLI1	Friend leukemia virus integration 1	2313	11	11q24 	yes		Ewing sarcoma			M	Dom	T	EWSR1		
+FLT3	fms-related tyrosine kinase 3	2322	13	13q12 	yes		AML, ALL			L	Dom	Mis, O			
+FNBP1	formin binding protein 1 (FBP17)	23048	9	9q23	yes		AML			L	Dom	T	MLL		
+FOXL2	forkhead box L2	668	3	3q23	yes		granulosa-cell tumour of the ovary			O	Dom	Mis		yes	Blepharophimosis, ptosis and epicanthus inversus Types I, II; Premature ovarian failure type III
+FOXO1A	forkhead box O1A (FKHR)	2308	13	13q14.1 	yes		alveolar rhabdomyosarcomas			M	Dom	T	PAX3		
+FOXO3A	forkhead box O3A	2309	6	6q21 	yes		AL			L	Dom	T	MLL		
+FOXP1	forkhead box P1	27086	3	3p14.1	yes		ALL			L	Dom	T	PAX5		
+FSTL3	follistatin-like 3 (secreted glycoprotein)	10272	19	19p13	yes		B-CLL			L	Dom	T	CCND1		
+FUS	fusion, derived from t(12;16) malignant liposarcoma	2521	16	16p11.2 	yes		liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma			M, L	Dom	T	DDIT3, ERG, FEV, ATF1, CREB3L2		
+FVT1	follicular lymphoma variant translocation 1	2531	18	18q21.3	yes		B-NHL			L	Dom	T	IGK@		
+GAS7	growth arrest-specific 7	8522	17	17p 	yes		AML*			L	Dom	T	MLL		
+GATA1	GATA binding protein 1 (globin transcription factor 1)	2623	X	Xp11.23 	yes		megakaryoblastic leukemia of Downs Syndrome			L	Dom	Mis, F			
+GATA2	GATA binding protein 2	2624	3	3q21.3 	yes		AML(CML blast transformation)			L	Dom	Mis			
+GATA3	GATA binding protein 3	2625	10	10p15	yes		breast			E	Rec	F, N, S		yes	HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)
+GMPS	guanine monphosphate synthetase	8833	3	3q24 	yes		AML			L	Dom	T	MLL		
+GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	2776	9	9q21	yes		uveal melanoma			E	Dom	Mis			
+GNAS	guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1	2778	20	20q13.2 	yes		pituitary adenoma			E	Dom	Mis		yes	McCune-Albright syndrome; pseudohypoparathyroidism, type IA
+GOLGA5	golgi autoantigen, golgin subfamily a, 5  (PTC5)	9950	14	14q	yes		papillary thyroid			E	Dom	T	RET		
+GOPC	golgi associated PDZ and coiled-coil motif containing	57120	6	6q21	yes		glioblastoma			O	Dom	O	ROS1		
+GPC3	glypican 3	2719	X	Xq26.1		yes		Wilms tumour	Simpson-Golabi-Behmel syndrome	O	Rec/X	T, D, Mis, N, F, S			
+GPHN	gephyrin (GPH)	10243	14	14q24 	yes		AL			L	Dom	T	MLL		
+GRAF	GTPase regulator associated with focal adhesion kinase pp125(FAK)	23092	5	5q31 	yes		AML, MDS			L	Dom	T, F, S	MLL		
+HCMOGT-1	sperm antigen HCMOGT-1	92521	17	17p11.2	yes		JMML			L	Dom	T	PDGFRB		
+HEAB	ATP_GTP binding protein	10978	11	11q12	yes		AML			L	Dom	T	MLL		
+HEI10	enhancer of invasion 10 - fused to HMGA2	57820	14	14q11.1	yes		uterine leiomyoma			M	Dom	T	HMGA2		
+HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	9709	16	16q12.2-q13	yes		prostate			E	Dom	T	ERG		
+HIP1	huntingtin interacting protein 1	3092	7	7q11.23	yes		CMML			L	Dom	T	PDGFRB		
+HIST1H4I	histone 1, H4i (H4FM)	8294	6	6p21.3 	yes		NHL			L	Dom	T	BCL6		
+HLF	hepatic leukemia factor	3131	17	17q22	yes		ALL			L	Dom	T	TCF3		
+HLXB9	homeo box HB9	3110	7	7q36	yes		AML			L	Dom	T	ETV6	yes	CURRARINO SYNDROME
+HMGA1	high mobility group AT-hook 1	3159	6	6p21	yes		microfollicular thyroid adenoma,  various benign mesenchymal tumors			E, M	Dom	T	?		
+HMGA2	high mobility group AT-hook 2 (HMGIC)	8091	12	12q15 	yes		lipoma			M	Dom	T	 LHFP, RAD51L1, LPP, HEI10, COX6C, CMKOR1, NFIB		
+HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	3181	7	7p15	yes		prostate			E	Dom	T	ETV1		
+HOOK3	hook homolog 3	84376	8	8p11.21	yes		papillary thyroid			E	Dom	T	RET		
+HOXA11	homeo box A11	3207	7	7p15-p14.2	yes		CML			L	Dom	T	NUP98		
+HOXA13	homeo box A13	3209	7	7p15-p14.2	yes		AML			L	Dom	T	NUP98		
+HOXA9	homeo box A9	3205	7	7p15-p14.2 	yes		AML*			L	Dom	T	NUP98, MSI2		
+HOXC11	homeo box C11	3227	12	12q13.3	yes		AML			L	Dom	T	NUP98		
+HOXC13	homeo box C13	3229	12	12q13.3	yes		AML			L	Dom	T	NUP98		
+HOXD11	homeo box D11	3237	2	2q31-q32	yes		AML			L	Dom	T	NUP98		
+HOXD13	homeo box D13	3239	2	2q31-q32 	yes		AML*			L	Dom	T	NUP98		
+HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	3265	11	11p15.5 	yes	yes	infrequent sarcomas, rare other types	rhadomyosarcoma, ganglioneuroblastoma, bladder	Costello syndrome	E, L, M	Dom	Mis			
+HRPT2	hyperparathyroidism 2 	3279	1	1q21-q31	yes	yes	parathyroid adenoma	parathyroid adenoma, mulitiple ossifying jaw fibroma 	Hyperparathyroidism-jaw tumor syndrome 	E, M	Rec	Mis, N, F			
+HSPCA	heat shock 90kDa protein 1, alpha	3320	14	14q32.31	yes		NHL			L	Dom	T	BCL6		
+HSPCB	heat shock 90kDa protein 1, beta	3326	6	6p12	yes		NHL			L	Dom	T	BCL6		
+IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	3417	2	2q33.3	yes		gliobastoma 			O	Dom	Mis			
+IDH2	socitrate dehydrogenase 2 (NADP+), mitochondrial 	3418	15	15q26.1	yes		GBM			M	Dom	M			
+IGH@	immunoglobulin heavy locus	3492	14	14q32.33	yes		MM, Burkitt lymphoma, NHL, CLL, B-ALL, MALT, MLCLS			L	Dom	T	MYC, FGFR3,PAX5, IRTA1, IRF4, CCND1, BCL9, BCL8, BCL6, BCL2, BCL3, BCL10, BCL11A. LHX4, DDX6, NFKB2, PAFAH1B2, PCSK7, CRLF2		
+IGK@	immunoglobulin kappa locus	50802	2	2p12	yes		Burkitt lymphoma, B-NHL			L	Dom	T	MYC, FVT1		
+IGL@	immunoglobulin lambda locus	3535	22	22q11.1-q11.2	yes		Burkitt lymphoma			L	Dom	T	BCL9, MYC, CCND2		
+IKZF1	IKAROS family zinc finger 1	10320	7	7p12.2	yes		ALL			L	Rec?	D			
+IL2	interleukin 2	3558	4	4q26-q27	yes		intestinal T-cell lymphoma			L	Dom	T	TNFRSF17		
+IL21R	interleukin 21 receptor	50615	16	16p11 	yes		NHL			L	Dom	T	BCL6		
+IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	3572	5	5q11	yes		hepatocellular ca			E	Dom	O			
+IRF4	interferon regulatory factor 4	3662	6	6p25-p23	yes		MM 			L	Dom	T	IGH@		
+IRTA1	immunoglobulin superfamily receptor translocation associated 1	83417	1	1q21	yes		B-NHL			L	Dom	T	IGH@		
+ITK	IL2-inducible T-cell kinase	3702	5	5q31-q32	yes		peripheral T-cell lymphoma			L	Dom	T	SYK		
+JAK1	Janus kinase 1	3716	1	1p32.3-p31.3	yes		ALL			L 	Dom	Mis			
+JAK2	Janus kinase 2 	3717	9	9p24 	yes		ALL, AML, MPD,  CML			L	Dom	T, Mis, O	ETV6, PCM1, BCR		
+JAK3	Janus kinase 3	3718	19	19p13.1	yes		acute megakaryocytic leukemia, 			L	Dom	Mis			
+JAZF1	juxtaposed with another zinc finger gene 1	221895	7	7p15.2-p15.1	yes		endometrial stromal tumours			M	Dom	T	SUZ12		
+JUN	jun oncogene	3725	1	1p32-p31	yes		sarcoma			M	Dom	A			
+KDM5A	lysine (K)-specific demethylase 5A, JARID1A	5927	12	12p11	yes		AML			L	Dom	T 	NUP98		
+KDM5C	lysine (K)-specific demethylase 5C (JARID1C)	8242	X	Xp11.22-p11.21	yes		clear cell renal carcinoma			E	Rec	N, F, S			
+KDM6A	lysine (K)-specific demethylase 6A, UTX	7403	X	Xp11.2	yes		renal, oesophageal SCC, MM			E, L	Rec	D, N, F, S			
+KDR	vascular endothelial growth factor receptor 2	3791	4	4q11-q12	yes		NSCLC, angiosarcoma			E	Dom	Mis			
+KIAA1549	KIAA1549	57670	7	7q34	yes		pilocytic astrocytoma			O	Dom	O	BRAF		
+KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 	3815	4	4q12	yes	yes	GIST, AML, TGCT, mastocytosis, mucosal melanoma	GIST, epithelioma	Familial gastrointestinal stromal tumour	L, M, O, E	Dom	Mis, O		yes	Piebald trait
+KLK2	kallikrein-related peptidase 2	3817	19	19q13.41	yes		prostate			E	Dom	T	ETV4		
+KRAS	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog	3845	12	12p12.1 	yes		pancreatic, colorectal, lung, thyroid, AML, others			L, E, M, O	Dom	Mis			
+KTN1	kinectin 1 (kinesin receptor)	3895	14	14q22.1	yes		papillary thryoid			E	Dom	T	RET		
+LAF4	lymphoid nuclear protein related to AF4	3899	2	2q11.2-q12 	yes		ALL, T-ALL			L	Dom	T	MLL, RUNX1		
+LASP1	LIM and SH3 protein 1	3927	17	17q11-q21.3	yes		AML			L	Dom	T	MLL		
+LCK	lymphocyte-specific protein tyrosine kinase	3932	1	1p35-p34.3 	yes		T-ALL			L	Dom	T	TRB@		
+LCP1	lymphocyte cytosolic protein 1 (L-plastin)	3936	13	 13q14.1-q14.3 	yes		NHL 			L	Dom	T	BCL6		
+LCX	leukemia-associated protein with a CXXC domain	80312	10	10q21	yes		AML			L	Dom	T	MLL		
+LHFP	lipoma HMGIC fusion partner	10186	13	13q12	yes		lipoma			M	Dom	T	HMGA2		
+LIFR	leukemia inhibitory factor receptor	3977	5	5p13-p12	yes		salivary adenoma			E	Dom	T	PLAG1		
+LMO1	LIM domain only 1 (rhombotin 1) (RBTN1)	4004	11	11p15 	yes		T-ALL			L	Dom	T	TRD@		
+LMO2	LIM domain only 2 (rhombotin-like 1) (RBTN2)	4005	11	11p13	yes		T-ALL			L	Dom	T	TRD@		
+LPP	LIM domain containing preferred translocation partner in lipoma	4026	3	3q28 	yes		lipoma, leukemia			L, M	Dom	T	HMGA2, MLL, C12orf9		
+LYL1	lymphoblastic leukemia derived sequence 1	4066	19	19p13.2-p13.1	yes		T-ALL			L	Dom	T	TRB@		
+MADH4	Homolog of Drosophila Mothers Against Decapentaplegic 4 gene	4089	18	18q21.1 	yes	yes	colorectal, pancreatic, small intestine 	gastrointestinal polyps	Juvenile polyposis	E	Rec	D, Mis, N, F			
+MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog	4094	16	16q22-q23	yes		MM			L	Dom	T	IGH@		
+MAFB	v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)	9935	20	20q11.2-q13.1	yes		MM			L	Dom	T	IGH@		
+MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	10892	18	18q21	yes		MALT			L	Dom	T	BIRC3		
+MAML2	mastermind-like 2 (Drosophila)	84441	11	11q22-q23	yes		salivary gland mucoepidermoid			E	Dom	T	MECT1, CRTC3		
+MAP2K4	mitogen-activated protein kinase kinase 4	6416	17	17p11.2 	yes		pancreatic, breast, colorectal			E	Rec	D, Mis, N			
+MDM2	Mdm2 p53 binding protein homolog	4193	12	12q15 	yes		sarcoma, glioma, colorectal, other			M, O, E, L	Dom	A			
+MDM4	Mdm4 p53 binding protein homolog	4194	1	1q32	yes		GBM, bladder, retinoblastoma			M	Dom	A			
+MDS1	myelodysplasia syndrome 1	4197	3	 3q26 	yes		MDS, AML			L	Dom	T	RUNX1		
+MDS2	myelodysplastic syndrome 2	259283	1	1p36	yes		MDS			L	Dom	T	ETV6		
+MECT1	mucoepidermoid translocated 1	94159	19	19p13	yes		salivary gland mucoepidermoid			E	Dom	T	MAML2		
+MEN1	multiple endocrine neoplasia type 1 gene	4221	11	11q13 	yes	yes	parathyroid tumors	parathyroid adenoma, pituitary adenoma, pancreatic islet cell, carcinoid	Multiple Endocrine Neoplasia Type 1	E	Rec	D, Mis, N, F, S			
+MET	met proto-oncogene (hepatocyte growth factor receptor)	4233	7	7q31	yes		papillary renal, head-neck squamous cell 	papillary renal	Familial Papillary Renal Cancer	E	Dom	Mis			
+MHC2TA	MHC class II transactivator	4261	16	16p13 	yes		NHL			L	Dom	T	BCL6		
+MITF	microphthalmia-associated transcription factor	4286	3	3p14.1	yes		melanoma 			E	Dom	A		yes	Waardenburg syndrome type 2, Tietz syndrome
+MKL1	megakaryoblastic leukemia (translocation) 1	57591	22	22q13	yes		acute megakaryocytic leukemia			L	Dom	T	RBM15		
+MLF1	myeloid leukemia factor 1	4291	3	3q25.1	yes		AML			L	Dom	T	NPM1		
+MLH1	E.coli MutL homolog gene	4292	3	3p21.3 	yes	yes	colorectal, endometrial, ovarian, CNS	colorectal, endometrial, ovarian, CNS	Hereditary non-polyposis colorectal cancer, Turcot syndrome	E, O	Rec	D, Mis, N, F, S			
+MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	4297	11	11q23 	yes		AML, ALL			L	Dom	T, O	MLL, MLLT1, MLLT2, MLLT3, MLLT4, MLLT7, MLLT10, MLLT6, ELL, EPS15, AF1Q, CREBBP, SH3GL1, FNBP1, PNUTL1, MSF, GPHN, GMPS, SSH3BP1, ARHGEF12, GAS7, FOXO3A, LAF4, LCX, SEPT6, LPP, CBFA2T1, GRAF, EP300, PICALM, HEAB		
+MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (ENL)	4298	19	19p13.3 	yes		AL			L	Dom	T	MLL		
+MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 (AF10)	8028	10	10p12 	yes		AL			L	Dom	T	MLL, PICALM, CDK6		
+MLLT2	 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 (AF4)	4299	4	4q21 	yes		AL			L	Dom	T	MLL		
+MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (AF9)	4300	9	9p22 	yes		ALL			L	Dom	T	MLL		
+MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (AF6)	4301	6	6q27 	yes		AL			L	Dom	T	MLL		
+MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 (AF17)	4302	17	17q21	yes		AL			L	Dom	T	MLL		
+MLLT7	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 (AFX1)	4303	X	Xq13.1 	yes		AL			L	Dom	T	MLL		
+MN1	meningioma (disrupted in balanced translocation) 1	4330	22	22q13	yes		AML, meningioma			L, O	Dom	T	ETV6		
+MPL	myeloproliferative leukemia virus oncogene, thrombopoietin receptor	4352	1	p34	yes	yes	MPD	MPD	Familial essential thrombocythemia	L	Dom	Mis		yes	congenital amegakaryocytic thrombocytopenia
+MSF	MLL septin-like fusion	10801	17	 17q25	yes		AML*			L	Dom	T	MLL		
+MSH2	mutS homolog 2 (E. coli)	4436	2	2p22-p21	yes	yes	colorectal, endometrial, ovarian	colorectal, endometrial, ovarian	Hereditary non-polyposis colorectal cancer	E	Rec	D, Mis, N, F, S			
+MSH6	mutS homolog 6 (E. coli)	2956	2	2p16	yes	yes	colorectal	colorectal, endometrial, ovarian	Hereditary non-polyposis colorectal cancer	E	Rec	Mis, N, F, S			
+MSI2	musashi homolog 2 (Drosophila)	124540	17	17q23.2	yes		CML			L	Dom	T	HOXA9		
+MSN	moesin	4478	X	Xq11.2-q12	yes		ALCL			L	Dom	T	ALK		
+MTCP1	mature T-cell proliferation 1	4515	X	Xq28	yes		T cell prolymphocytic leukemia			L	Dom	T	TRA@		
+MUC1	mucin 1, transmembrane	4582	1	1q21	yes		B-NHL			L	Dom	T	IGH@		
+MUTYH	mutY homolog (E. coli)	4595	1	1p34.3-1p32.1 		yes		colorectal	Adenomatous polyposis coli	E	Rec	Mis			
+MYB	v-myb myeloblastosis viral oncogene homolog	4602	6	6q22-23	yes		adenoid cystic carcinoma			E	Dom	T	NFIB		
+MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	4609	8	8q24.12-q24.13 	yes		Burkitt lymphoma,  amplified in other cancers, B-CLL			L, E	Dom	A, T	IGK@, BCL5, BCL7A , BTG1, TRA@, IGH@		
+MYCL1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	4610	1	1p34.3 	yes		small cell lung 			E	Dom	A			
+MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	4613	2	2p24.1 	yes		neuroblastoma			O	Dom	A			
+MYH11	myosin, heavy polypeptide 11, smooth muscle	4629	16	16p13.13-p13.12 	yes		AML			L	Dom	T	CBFB		
+MYH9	myosin, heavy polypeptide 9, non-muscle	4627	22	22q13.1	yes		ALCL			L	Dom	T	ALK	yes	Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome
+MYST4	MYST histone acetyltransferase (monocytic leukemia) 4 (MORF)	23522	10	10q22 	yes		AML			L	Dom	T	CREBBP		
+NACA	nascent-polypeptide-associated complex alpha polypeptide	4666	12	12q23-q24.1 	yes		NHL			L	Dom	T	BCL6		
+NBS1	Nijmegen breakage syndrome 1 (nibrin)	4683	8	8q21		yes		NHL, glioma, medulloblastoma, rhabdomyosarcoma	Nijmegen breakage syndrome 	L, E, M, O	Rec	Mis, N, F			
+NCOA1	nuclear receptor coactivator 1	8648	2	2p23	yes		alveolar rhadomyosarcoma			M	Dom	T	PAX3		
+NCOA2	nuclear receptor coactivator 2 (TIF2)	10499	8	8q13.1	yes		AML			L	Dom	T	RUNXBP2		
+NCOA4	nuclear receptor coactivator 4 - PTC3 (ELE1)	8031	10	10q11.2 	yes		papillary thyroid 			E	Dom	T	RET		
+NF1	neurofibromatosis type 1 gene	4763	17	17q12	yes	yes	neurofibroma, glioma	neurofibroma, glioma	Neurofibromatosis type 1	O	Rec	D, Mis, N, F, S, O			
+NF2	neurofibromatosis type 2 gene	4771	22	22q12.2 	yes	yes	meningioma, acoustic neuroma, renal 	meningioma, acoustic neuroma	Neurofibromatosis type 2	O	Rec	D, Mis, N, F, S, O			
+NFIB	nuclear factor I/B	4781	9	9p24.1	yes		adenoid cystic carcinoma, lipoma			E	Dom	T	MYB, HGMA2		
+NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	4791	10	10q24	yes		B-NHL			L	Dom	T	IGH@		
+NIN	ninein (GSK3B interacting protein)	51199	14	14q24	yes		MPD			L	Dom	T	PDGFRB		
+NONO	non-POU domain containing, octamer-binding	4841	X	Xq13.1	yes		papillary renal cancer			E	Dom	T	TFE3		
+NOTCH1	Notch homolog 1, translocation-associated (Drosophila) (TAN1)	4851	9	 9q34.3 	yes		T-ALL			L	Dom	T, Mis, O	TRB@		
+NOTCH2	Notch homolog 2	4853	1	1p13-p11	yes		marginal zone lymphoma, DLBCL			L	Dom	N, F, Mis			
+NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	4869	5	5q35	yes		NHL, APL, AML			L	Dom	T, F 	ALK, RARA, MLF1		
+NR4A3	nuclear receptor subfamily 4, group A, member 3 (NOR1)	8013	9	9q22 	yes		extraskeletal myxoid chondrosarcoma			M	Dom	T	EWSR1		
+NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	4893	1	1p13.2 	yes		melanoma, MM, AML, thyroid			L, E	Dom	Mis			
+NSD1	nuclear receptor binding SET domain protein 1	64324	5	5q35 	yes		AML			L	Dom	T	NUP98	yes	Sotos Syndrome
+NTRK1	neurotrophic tyrosine kinase, receptor, type 1	4914	1	1q21-q22 	yes		papillary thyroid			E	Dom	T	TPM3, TPR, TFG		
+NTRK3	neurotrophic tyrosine kinase, receptor, type 3	4916	15	15q25 	yes		congenital fibrosarcoma, Secretory breast 			E, M	Dom	T	ETV6		
+NUMA1	nuclear mitotic apparatus protein 1	4926	11	11q13	yes		APL			L	Dom	T	RARA		
+NUP214	nucleoporin 214kDa (CAN)	8021	9	9q34.1	yes		AML, T-ALL			L	Dom	T	DEK, SET, ABL1		
+NUP98	nucleoporin 98kDa	4928	11	11p15 	yes		AML			L	Dom	T	HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11		
+NUT	nuclear protien in testis	256646	15	q13	yes		lethal midline carcinoma of young people			E	Dom	T	BRD4, BRD3		
+OLIG2	oligodendrocyte lineage transcription factor 2 (BHLHB1)	10215	21	21q22.11	yes		T-ALL			L	Dom	T	TRA@		
+OMD	osteomodulin	4958	9	9q22.31	yes		aneurysmal bone cysts			M	Dom	T	USP6		
+P2RY8	purinergic receptor P2Y, G-protein coupled, 8	286530	X,Y	Xp22.3; Yp11.3	yes		B-ALL, Downs associated ALL			L	Dom	T	CRLF2		
+PAFAH1B2	platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDa	5049	11	11q23	yes		MLCLS			L	Dom	T	IGH@		
+PALB2	partner and localizer of BRCA2	79728	16	16p12.1		yes		Wilms tumor, medulloblastoma, AML ,breast	Fanconi anaemia N, breast cancer susceptibility 	L, O, E	Rec	F, N, Mis			
+PAX3	paired box gene 3 	5077	2	2q35	yes		alveolar rhabdomyosarcoma			M	Dom	T	FOXO1A, NCOA1	yes	Waardenburg syndrome; craniofacial-deafness-hand syndrome
+PAX5	paired box gene 5 (B-cell lineage specific activator protein)	5079	9	9p13	yes		NHL, ALL, B-ALL			L	Dom	T, Mis, D, F, S	IGH@, ETV6, PML, FOXP1, ZNF521, ELN		
+PAX7	paired box gene 7	5081	1	1p36.2-p36.12 	yes		alveolar rhabdomyosarcoma			M	Dom	T	FOXO1A		
+PAX8	paired box gene 8	7849	2	2q12-q14 	yes		follicular thyroid			E	Dom	T	PPARG	yes	Thyroid dysgenesis 
+PBX1	pre-B-cell leukemia transcription factor 1	5087	1	1q23 	yes		pre B-ALL, myoepithelioma			L, M	Dom	T	TCF3, EWSR1		
+PCM1	pericentriolar material 1  (PTC4)	5108	8	8p22-p21.3 	yes		papillary thyroid, CML, MPD			E, L	Dom	T	RET, JAK2		
+PCSK7	proprotein convertase subtilisin/kexin type 7	9159	11	11q23.3	yes		MLCLS			L	Dom	T	IGH@		
+PDE4DIP	phosphodiesterase 4D interacting protein (myomegalin)	9659	1	1q12	yes		MPD			L	Dom	T	PDGFRB		
+PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	5155	22	22q12.3-q13.1	yes		DFSP			M	Dom	T	COL1A1		
+PDGFRA	platelet-derived growth factor, alpha-receptor	5156	4	4q11-q13	yes		GIST, idiopathic hypereosinophilic syndrome			L, M, O	Dom	Mis, O, T	FIP1L1		
+PDGFRB	platelet-derived growth factor receptor, beta polypeptide	5159	5	5q31-q32 	yes		MPD, AML, CMML, CML			L	Dom	T	ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP		
+PER1	period homolog 1 (Drosophila)	5187	17	17p13.1-17p12	yes		AML, CMML			L	Dom	T	ETV6		
+PHOX2B	paired-like homeobox 2b	8929	4	4p12	yes	yes	neuroblastoma	neuroblastoma	familial neuroblastoma	O	Rec	Mis, F		yes	congenital central hypoventilation syndrome
+PICALM	phosphatidylinositol binding clathrin assembly protein (CALM)	8301	11	11q14 	yes		TALL, AML, 			L	Dom	T	MLLT10, MLL		
+PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	5290	3	3q26.3	yes		colorectal, gastric, gliobastoma, breast			E, O	Dom	Mis			
+PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5295	5	5q13.1	yes		gliobastoma, ovarian, colorectal			E, O	Rec	Mis, F, O			
+PIM1	pim-1 oncogene	5292	6	6p21.2 	yes		NHL			L	Dom	T	BCL6		
+PLAG1	pleiomorphic adenoma gene 1	5324	8	8q12	yes		salivary adenoma			E	Dom	T	TCEA1, LIFR, CTNNB1, CHCHD7		
+PML	promyelocytic leukemia	5371	15	15q22 	yes		APL, ALL			L	Dom	T	RARA, PAX5		
+PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	5378	2	2q31-q33 		yes		colorectal, endometrial, ovarian	Hereditary non-polyposis colorectal cancer	E	Rec	Mis, N			
+PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	5395	7	7p22 		yes		colorectal, endometrial, ovarian, medulloblastoma, glioma	Hereditary non-polyposis colorectal cancer, Turcot syndrome	E	Rec	Mis, N, F			
+PMX1	paired mesoderm homeo box 1	5396	1	1q24 	yes		AML			L	Dom	T	NUP98		
+PNUTL1	peanut-like 1 (Drosophila)	5413	22	22q11.2 	yes		AML			L	Dom	T	MLL		
+POU2AF1	POU domain, class 2, associating factor 1 (OBF1)	5450	11	11q23.1 	yes		NHL			L	Dom	T	BCL6		
+POU5F1	POU domain, class 5, transcription factor 1	5460	6	6p21.31	yes		sarcoma			M	Dom	T	EWSR1		
+PPARG	peroxisome proliferative activated receptor, gamma	5468	3	 3p25 	yes		follicular thyroid			E	Dom	T	PAX8	yes	Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension
+PRCC	papillary renal cell carcinoma (translocation-associated)	5546	1	1q21.1	yes		papillary renal 			E	Dom	T	TFE3		
+PRDM16	PR domain containing 16	63976	1	1p36.23-p33	yes		MDS, AML			L	Dom	T	EVI1		
+PRF1	perforin 1 (pore forming protein)	5551	10	10q22		yes		various leukaemia, lymphoma		L	Rec	M			Type 2 familial hemophagocytic lymphohistiocytosis
+PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	5573	17	17q23-q24	yes	yes	papillary thyroid	myxoma, endocrine, papillary thyroid	Carney complex	E, M	Dom, Rec	T, Mis, N, F, S	RET		
+PRO1073	PRO1073 protein (ALPHA) 	29005	11	11q31.1	yes		renal cell carcinoma (childhood epithelioid)			E	Dom	T	TFEB		
+PSIP2	PC4 and SFRS1 interacting protein 2 (LEDGF)	11168	9	9p22.2	yes		AML			L	Dom	T	NUP98		
+PTCH	Homolog of Drosophila Patched gene	5727	9	9q22.3	yes	yes	skin basal cell , medulloblastoma	skin basal cell, medulloblastoma	Nevoid Basal Cell Carcinoma Syndrome	E, M	Rec	Mis, N, F, S			
+PTEN	phosphatase and tensin homolog gene	5728	10	10q23.3	yes	yes	glioma,  prostate, endometrial	harmartoma, glioma,  prostate, endometrial	Cowden Syndrome, Bannayan-Riley-Ruvalcaba syndrome	L, E, M, O	Rec	D, Mis, N, F, S			
+PTPN11	protein tyrosine phosphatase, non-receptor type 11	5781	12	12q24.1	yes		JMML, AML, MDS			L	Dom	Mis		yes	Noonan Syndrome
+RAB5EP	rabaptin, RAB GTPase binding effector protein 1 (RABPT5)	9135	17	17p13	yes		CMML			L	Dom	T	PDGFRB		
+RAD51L1	RAD51-like 1 (S. cerevisiae) (RAD51B)	5890	14	14q23-q24.2	yes		lipoma, uterine leiomyoma			M	Dom	T	HMGA2		
+RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	5894	3	3p25	yes		pilocytic astrocytoma			M	Dom	T	SRGAP3		
+RANBP17	RAN binding protein 17	64901	5	5q34	yes		ALL			L	Dom	T	TRD@		
+RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	5910	4	4q21-q25	yes		T-ALL			L	Dom	T	NUP98		
+RARA	retinoic acid receptor, alpha	5914	17	 17q12 	yes		APL			L	Dom	T	PML, ZNF145, TIF1, NUMA1, NPM1		
+RB1	retinoblastoma gene	5925	13	13q14	yes	yes	retinoblastoma, sarcoma, breast, small cell lung	retinoblastoma, sarcoma, breast, small cell lung	Familial retinoblastoma	L, E, M, O	Rec	D, Mis, N, F, S			
+RBM15	RNA binding motif protein 15	64783	1	1p13	yes		acute megakaryocytic leukemia			L	Dom	T	MKL1		
+RECQL4	RecQ protein-like 4	9401	8	8q24.3		yes		osteosarcoma, skin basal and sqamous cell	Rothmund-Thompson Syndrome	M	Rec	N, F, S			
+REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	5966	2	 2p13-p12	yes		Hodgkin Lymphoma			L	Dom	A			
+RET	ret proto-oncogene 	5979	10	10q11.2 	yes	yes	medullary thyroid,  papillary thyroid, pheochromocytoma	medullary thyroid,  papillary thyroid, pheochromocytoma	Multiple endocrine neoplasia 2A/2B	E, O	Dom	T, Mis, N, F	H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3	yes	Hirschsprung disease
+ROS1	v-ros UR2 sarcoma virus oncogene homolog 1 (avian)	6098	6	6q22	yes		glioblastoma, NSCLC			O	Dom	T	GOPC, ROS1		
+RPL22	ribosomal protein L22 (EAP)	6146	1	1p36.31	yes		AML, CML			L	Dom	T	RUNX1		
+RPN1	ribophorin I	6184	3	3q21.3-q25.2	yes		AML			L	Dom	T	EVI1		
+RUNX1	 runt-related transcription factor 1  (AML1)	861	21	21q22.3 	yes		AML, preB- ALL, T-ALL			L	Dom	T	RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4		
+RUNXBP2	runt-related transcription factor binding protein 2 (MOZ/ZNF220)	7994	8	8p11	yes		AML			L	Dom	T	CREBBP, NCOA2, EP300		
+SBDS	Shwachman-Bodian-Diamond syndrome protein	51119	7	7q11		yes		AML, MDS	Schwachman-Diamond syndrome	L	Rec	Gene Conversion			
+SDH5	chromosome 11 open reading frame 79	54949	11	11q12.2		yes		paraganglioma	Familial paraganglioma	M	Rec	M			
+SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	6390	1	1p36.1-p35 		yes		paraganglioma, pheochromocytoma	Familial paraganglioma	O	Rec	Mis, N, F			
+SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	6391	1	1q21 		yes		paraganglioma, pheochromocytoma	Familial paraganglioma	O	Rec	Mis, N, F			
+SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	6392	11	11q23 		yes		paraganglioma, pheochromocytoma	Familial paraganglioma	O	Rec	Mis, N, F, S			
+SEPT6	septin 6	23157	X	Xq24	yes		AML			L	Dom	T	MLL		
+SET	SET translocation 	6418	9	9q34	yes		AML			L	Dom	T	NUP214		
+SETD2	SET domain containing 2	29072	3	3p21.31	yes		clear cell renal carcinoma			E	Rec	N, F, S, Mis			
+SFPQ	splicing factor proline/glutamine rich(polypyrimidine tract binding protein associated)	6421	1	1p34.3	yes		papillary renal cell			E	Dom	T	TFE3		
+SFRS3	splicing factor, arginine/serine-rich 3	6428	6	6p21	yes		follicular lymphoma			L	Dom	T	BCL6		
+SH3GL1	SH3-domain GRB2-like 1 (EEN)	6455	19	 19p13.3 	yes		AL			L	Dom	T	MLL		
+SIL	TAL1 (SCL) interrupting locus	6491	1	1p32	yes		T-ALL			L	Dom	T	TAL1		
+SLC45A3	solute carrier family 45, member 3	85414	1	1q32	yes		prostate 			E	Dom	T	ETV1, ETV5, ELK4, ERG		
+SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	6597	19	19p13.2	yes		NSCLC			E	Rec	F, N, Mis			
+SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	6598	22	22q11 	yes	yes	malignant rhabdoid 	malignant rhabdoid	Rhabdoid predisposition syndrome	M	Rec	D, N, F, S			
+SMO	smoothened homolog (Drosophila)	6608	7	7q31-q32 	yes		skin basal cell 			E	Dom	Mis			
+SOCS1	suppressor of cytokine signaling 1 	8651  	16	16p13.13	yes		Hodgkin Lymphoma, PMBL			L	Rec	F, O			
+SRGAP3	SLIT-ROBO Rho GTPase activating protein 3	9901	3	3p25.3	yes		pilocytic astrocytoma			M	Dom	T	RAF1		
+SS18	synovial sarcoma translocation, chromosome 18	6760	18	18q11.2	yes		synovial sarcoma			M	Dom	T	SSX1,  SSX2		
+SS18L1	synovial sarcoma translocation gene on chromosome 18-like 1	26039	20	20q13.3	yes		synovial sarcoma			M	Dom	T	SSX1		
+SSH3BP1	spectrin SH3 domain binding protein 1	10006	10	10p11.2 	yes		AML			L	Dom	T	MLL		
+SSX1 	synovial sarcoma, X breakpoint 1	6756	X	Xp11.23-p11.22	yes		synovial sarcoma			M	Dom	T	SS18		
+SSX2	synovial sarcoma, X breakpoint 2	6757	X	Xp11.23-p11.22	yes		synovial sarcoma			M	Dom	T	SS18		
+SSX4	synovial sarcoma, X breakpoint 4	6759	X	Xp11.23	yes		synovial sarcoma			M	Dom	T	SS18		
+STK11	serine/threonine kinase 11 gene (LKB1)	6794	19	19p13.3	yes	yes	NSCLC, pancreatic	jejunal harmartoma, ovarian, testicular, pancreatic	Peutz-Jeghers syndrome	E, M, O	Rec	D, Mis, N, F, S			
+STL	Six-twelve leukemia gene	7955	6	6q23 	yes		B-ALL			L	Dom	T	ETV6		
+SUFU	suppressor of fused homolog (Drosophila)	51684	10	10q24.32	yes	yes	medulloblastoma	medulloblastoma	Medulloblastoma predisposition	O	Rec	D, F, S			
+SUZ12	suppressor of zeste 12 homolog (Drosophila)	23512	17	17q11.2	yes		endometrial stromal tumours			M	Dom	T	JAZF1		
+SYK	spleen tyrosine kinase	6850	9	9q22	yes		MDS, peripheral T-cell lymphoma			L	Dom	T	ETV6, ITK		
+TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	8148	17	17q11.1-q11.2	yes		extraskeletal myxoid chondrosarcomas, ALL			L, M	Dom	T	TEC, CHN1, ZNF384		
+TAL1	T-cell acute lymphocytic leukemia 1 (SCL)	6886	1	1p32 	yes		lymphoblastic leukemia/biphasic			L	Dom	T	TRD@, SIL		
+TAL2	T-cell acute lymphocytic leukemia 2	6887	9	9q31	yes		T-ALL			L	Dom	T	TRB@		
+TCEA1	transcription elongation factor A (SII), 1	6917	8	8q11.2	yes		salivary adenoma			E	Dom	T	PLAG1		
+TCF1	transcription factor 1, hepatic (HNF1)	6927	12	12q24.2	yes	yes	hepatic adenoma, hepatocellular ca	hepatic adenoma, hepatocellular ca	Familial Hepatic Adenoma	E	Rec	Mis, F		yes	Maturity-onset diabetes of the young, TYPE III
+TCF12	transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)	6938	15	15q21	yes		extraskeletal myxoid chondrosarcoma			M	Dom	T	TEC		
+TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	6929	19	19p13.3 	yes		pre B-ALL			L	Dom	T	PBX1, HLF, TFPT		
+TCL1A	T-cell leukemia/lymphoma 1A	8115	14	14q32.1	yes		T-CLL			L	Dom	T	TRA@		
+TCL6	T-cell leukemia/lymphoma 6	27004	14	14q32.1	yes		T-ALL			L	Dom	T	TRA@		
+TET2	tet oncogene family member 2	54790	4	4q24	yes		MDS			L	Rec	Mis N, F			
+TFE3	transcription factor binding to IGHM enhancer 3	7030	X	Xp11.22	yes		papillary renal, alveolar soft part sarcoma, renal			E	Dom	T	SFPQ, ASPSCR1, PRCC, NONO, CLTC		
+TFEB	transcription factor EB	7942	6	6p21	yes		renal (childhood epithelioid)			E,M	Dom	T	ALPHA		
+TFG	TRK-fused gene	10342	3	3q11-q12	yes		papillary thyroid, ALCL, NSCLC			E, L	Dom	T	NTRK1, ALK		
+TFPT	TCF3 (E2A) fusion partner (in childhood Leukemia)	29844	19	19q13	yes		pre-B ALL			L	Dom	T	TCF3		
+TFRC	transferrin receptor (p90, CD71)	7037	3	3q29 	yes		NHL			L	Dom	T	BCL6		
+THRAP3	thyroid hormone receptor associated protein 3 (TRAP150)	9967	1	1p34.3	yes		aneurysmal bone cysts			M	Dom	T	USP6		
+TIF1	transcriptional intermediary factor 1  (PTC6,TIF1A)	8805	7	7q32-q34 	yes		APL			L	Dom	T	RARA		
+TLX1	 T-cell leukemia, homeobox 1 (HOX11)	3195	10	10q24	yes		T-ALL			L	Dom	T	TRB@, TRD@		
+TLX3	T-cell leukemia, homeobox 3 (HOX11L2)	30012	5	5q35.1	yes		T-ALL			L	Dom	T	BCL11B		
+TMPRSS2	transmembrane protease, serine 2	7113	21	21q22.3	yes		prostate 			E	Dom	T	ERG, ETV1, ETV4, ETV5		
+TNFAIP3	tumor necrosis factor, alpha-induced protein 3	7128	6	6q23	yes		marginal zone B-cell lymphomas, Hodgkin's lymphoma, primary mediastinal B cell lymphoma			L	Rec	D, N, F			
+TNFRSF17	tumor necrosis factor receptor superfamily, member 17	608	16	16p13.1	yes		intestinal T-cell lymphoma			L	Dom	T	IL2		
+TNFRSF6	tumor necrosis factor receptor superfamily, member 6 (FAS)	355	10	10q24.1	yes		TGCT, nasal NK/T lymphoma, skin squamous cell ca -burn scar-related			L, E, O	Rec	Mis 		yes	Autoimmune lymphoproliferative syndrome
+TOP1	topoisomerase (DNA) I	7150	20	20q12-q13.1 	yes		AML*			L	Dom	T	NUP98		
+TP53	tumor protein p53	7157	17	17p13	yes	yes	breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types	breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types	Li-Fraumeni syndrome	L, E, M, O	Rec	Mis, N, F			
+TPM3	tropomyosin 3	7170	1	1q22-q23 	yes		papillary thyroid, ALCL			E, L	Dom	T	NTRK1, ALK		
+TPM4	tropomyosin 4	7171	19	19p13.1	yes		ALCL			L	Dom	T	ALK		
+TPR	translocated promoter region 	7175	1	1q25 	yes		papillary thyroid			E	Dom	T	NTRK1		
+TRA@	T cell receptor alpha locus	6955	14	14q11.2	yes		T-ALL			L	Dom	T	ATL,OLIG2, MYC, TCL1A, TCL6, MTCP1, TCL6		
+TRB@	T cell receptor beta locus	6957	7	7q35 	yes		T-ALL			L	Dom	T	HOX11, LCK, NOTCH1, TAL2, LYL1		
+TRD@	T cell receptor delta locus	6964	14	14q11	yes		T-cell leukemia			L	Dom	T	TAL1, HOX11, TLX1, LMO1, LMO2, RANBP17		
+TRIM27	tripartite motif-containing 27	5987	6	6p22	yes		papillary thyroid			E	Dom	T	RET		
+TRIM33	 tripartite motif-containing 33 (PTC7,TIF1G)	51592	1	1p13	yes		papillary thyroid			E	Dom	T	RET		
+TRIP11	thyroid hormone receptor interactor 11	9321	14	14q31-q32 	yes		AML			L	Dom	T	PDGFRB		
+TSC1	tuberous sclerosis 1 gene	7248	9	9q34 		yes		hamartoma, renal cell	Tuberous sclerosis 1	E, O	Rec	D, Mis, N, F, S			
+TSC2	tuberous sclerosis 2 gene	7249	16	16p13.3 		yes		hamartoma, renal cell	Tuberous sclerosis 2	E, O	Rec	D, Mis, N, F, S			
+TSHR	thyroid stimulating hormone receptor	7253	14	14q31 	yes	yes	toxic thyroid adenoma	thyroid  adenoma		E	Dom	Mis		yes	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 
+TTL	tubulin tyrosine ligase	150465	2	2q13	yes		ALL			L	Dom	T	ETV6		
+USP6	ubiquitin specific peptidase 6 (Tre-2 oncogene)	9098	17	17p13	yes		aneurysmal bone cysts			M	Dom	T	COL1A1, CDH11, ZNF9, OMD		
+VHL	von Hippel-Lindau syndrome gene	7428	3	3p25	yes	yes	renal, hemangioma, pheochromocytoma	renal, hemangioma, pheochromocytoma	von Hippel-Lindau syndrome	E, M, O	Rec	D, Mis, N, F, S			
+WAS	Wiskott-Aldrich syndrome 	7454	X	Xp11.23-p11.22				lymphoma	Wiskott-Aldrich syndrome	L	X-linked recessive	Mis, N, F, S			
+WHSC1	Wolf-Hirschhorn syndrome candidate 1(MMSET)	7468	4	4p16.3	yes		MM			L	Dom	T	IGH@		
+WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1 (NSD3)	54904	8	8p12 	yes		AML			L	Dom	T	NUP98		
+WRN	Werner syndrome (RECQL2)	7486	8	8p12-p11.2		yes		osteosarcoma, meningioma, others	Werner Syndrome	L, E, M, O	Rec	Mis, N, F, S			
+WT1	Wilms tumour 1 gene	7490	11	11p13	yes	yes	Wilms, desmoplastic small round cell tumor	Wilms	Denys-Drash syndrome, Frasier syndrome, Familial Wilms tumor	O	Rec	D, Mis, N, F, S	EWSR1		
+WTX	family with sequence similarity 123B (FAM123B)	139285	X	Xq11.1	yes		Wilms tumour			O	Rec	F, D, N, Mis			
+XPA	xeroderma pigmentosum, complementation group A	7507	9	9q22.3		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (A) 	E	Rec	Mis, N, F, S			
+XPC	xeroderma pigmentosum, complementation group C	7508	3	3p25		yes		skin basal cell, skin squamous cell, melanoma	Xeroderma pigmentosum (C) 	E	Rec	Mis, N, F, S			
+ZNF145	zinc finger protein 145 (PLZF)	7704	11	11q23.1 	yes		APL			L	Dom	T	RARA		
+ZNF198	zinc finger protein 198	7750	13	13q11-q12	yes		MPD, NHL			L	Dom	T	FGFR1		
+ZNF278	zinc finger protein 278 (ZSG)	23598	22	22q12-q14 	yes		Ewing sarcoma			M	Dom	T	EWSR1		
+ZNF331	zinc finger protein 331	55422	19	19q13.3-q13.4	yes		follicular thyroid adenoma			E	Dom	T	?		
+ZNF384	zinc finger protein 384 (CIZ/NMP4)	171017	12	12p13 	yes		ALL			L 	Dom	T	EWSR1, TAF15 		
+ZNF521	zinc finger protein 521	25925	18	18q11.2	yes		ALL			L	Dom	T	PAX5		
+ZNF9	zinc finger protein 9 (a cellular retroviral nucleic acid binding protein)	7555	3	3q21	yes		aneurysmal bone cysts			M	Dom	T	USP6		
+ZNFN1A1	zinc finger protein, subfamily 1A, 1 (Ikaros)	10320	7	7p12 	yes		ALL, DLBL			L	Dom	T	BCL6		

data/share/install/Biogrid/Rakefile

@@ -0,0 +1,20 @@
+require File.join(File.dirname(__FILE__),'../lib/rake_helper')
+require 'rbbt/sources/organism'
+
+BIOGRID_URL = "http://thebiogrid.org/downloads/archives/Release%20Archive/BIOGRID-3.1.77/BIOGRID-ORGANISM-3.1.77.tab2.zip"
+
+file 'source' do |t|
+  FileUtils.mkdir_p t.name
+  Misc.in_dir(t.name) do
+    CMD::cmd("wget '#{BIOGRID_URL}' -O biogrid.zip")
+    CMD::cmd('unzip biogrid.zip')
+  end
+end
+
+rule /(\w+)\/protein_protein/ => 'source' do |t|
+  org = t.name.match(/(\w+)\/protein_protein/)[1]
+  FileUtils.mkdir_p File.dirname(t.name)
+  name = Organism.name(org)
+  source_file = Dir.glob(File.join(t.prerequisites.first, '*')).select{|file| file =~  /#{name.sub(' ', '_')}/}.first
+  FileUtils.cp source_file, t.name
+end

data/share/install/DBSNP/Rakefile

@@ -0,0 +1,50 @@
+require 'rbbt-util'
+require 'nokogiri'
+
+URL="http://www.snpedia.com/index.php/"
+
+file :snps do |t|
+  all_snps = Open.read("http://www.snpedia.com/files/gbrowse/snpedia.gff").scan(/rs\d+/).uniq
+
+  data = TSV.new({}, :double)
+  data.key_field = "SNP ID"
+  data.fields = %w(Genotype Effect Magnitude)
+  all_snps.each{|snp|
+    begin
+      doc = Nokogiri::HTML(Open.read(File.join(URL, snp)))
+    rescue
+      puts "SNP #{ snp } not found"
+      next
+    end
+
+    table = doc.css('table#querytable4').first
+
+    if table.nil?
+      puts "No table for #{ snp }"
+      next
+    end
+
+    info = []
+    table.css("tr")[1..-1].each do |row|
+      genotype, magnitude, effect = row.css("td")
+
+      genotype = genotype.content.match(/\((.*)\)/)[1]
+
+      if  magnitude.css("span").empty?
+        magnitude = ""
+      else
+        magnitude = magnitude.css("span").first.content
+      end
+
+      effect = effect.content
+     
+      info << [genotype, magnitude, effect]
+    end
+
+    info = NamedArray.name(info,  %w(Genotype Effect Magnitude))
+    data[snp] = info.zip_fields
+  }
+
+  Open.write(t.name, data.to_s)
+end
+