rails-clustergrammer 0.1.0 → 0.1.1

checksums.yaml

@@ -1,7 +1,7 @@
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+  data.tar.gz: 031230a8a39f3435cc0266be56a720daae37bab435e596dbaea04fcf930df2a5
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+  data.tar.gz: a49c44ce93d10c02eef417b515b9c01777d649eff30eace99a85da6d8775d02c9214609ab2c6edcc0f5b481461c92fa1503ef964e91c4ec0ed82fd177e302315

data/.gitignore

@@ -6,6 +6,7 @@
 /pkg/
 /spec/reports/
 /tmp/
+.DS_Store
 
 # rspec failure tracking
 .rspec_status

data/Gemfile.lock

@@ -1,7 +1,7 @@
 PATH
   remote: .
   specs:
-    rails-clustergrammer (0.1.0)
+    rails-clustergrammer (0.1.1)
 
 GEM
   remote: https://rubygems.org/

data/README.md

@@ -20,8 +20,19 @@ Or install it yourself as:
 
 ## Usage
 
+
+Add require javascript and gem 
+```ruby
+gem 'underscore-rails', '~> 1.8', '>= 1.8.3'
+gem 'd3_rails', '~> 4.1', '>= 4.1.1'
+```
+
 Add the clustergrammer to your manifest file:
+```ruby
+    //= require d3
+    //= require underscore
     //= require clustergrammer
+```
 
 ## Development
 

data/lib/rails/clustergrammer/version.rb

@@ -1,5 +1,5 @@
 module Rails
   module Clustergrammer
-    VERSION = "0.1.0"
+    VERSION = "0.1.1"
   end
 end

data/vendor/assets/javascripts/Enrichrgram.js

@@ -0,0 +1,755 @@
+var genes_were_found = {};
+enr_obj = {};
+
+function check_setup_enrichr(inst_cgm){
+
+  var has_enrichrgram = _.has(inst_cgm.params.network_data, 'enrichrgram');
+
+  var make_enrichrgram = false;
+  if (has_enrichrgram){
+    make_enrichrgram = inst_cgm.params.network_data.enrichrgram;
+  }
+
+  // Toggle Enrichrgram function
+  if (has_enrichrgram === false){
+
+    // check with Hzome whether rows are genes
+    ////////////////////////////////////////////
+    genes_were_found[inst_cgm.params.root] = false;
+
+    var all_rows = inst_cgm.params.network_data.row_nodes_names;
+    var max_num_genes = 20;
+
+    if (all_rows.length > 20){
+      all_rows = all_rows.slice(0,20);
+    }
+
+    var wait_unit = 500;
+    var wait_time = 0;
+
+    _.each(all_rows, function(inst_name){
+      setTimeout(check_gene_request, wait_time, inst_cgm, inst_name, run_ini_enrichr);
+      wait_time = wait_time + wait_unit;
+    });
+
+  } else if (make_enrichrgram) {
+
+    // make enrichrgram without checking with Hzome
+    /////////////////////////////////////////////////
+    run_ini_enrichr(inst_cgm);
+
+    genes_were_found[inst_cgm.params.root] = true;
+
+  }
+
+}
+
+function run_ini_enrichr(inst_cgm){
+
+  var inst_root = inst_cgm.params.root;
+
+  var has_enrichrgram = _.has(inst_cgm.params.network_data, 'enrichrgram');
+
+  var make_enrichrgram = false;
+  if (has_enrichrgram){
+    make_enrichrgram = inst_cgm.params.network_data.enrichrgram;
+  }
+
+  if (genes_were_found[inst_root] || make_enrichrgram){
+
+    if (d3.select(inst_root + ' .enrichr_logo').empty()){
+
+      // set up Enrichr category import
+      enr_obj[inst_root] = Enrichrgram(inst_cgm);
+      enr_obj[inst_root].enrichr_icon();
+
+      // set up Enrichr export in dendro modal
+      //////////////////////////////////////////
+
+      // only display for rows
+      var enrichr_section = d3.selectAll(inst_root + ' .dendro_info')
+        .select('.modal-body')
+        .append('div')
+        .classed('enrichr_export_section', true)
+        .style('margin-top', '10px');
+        // .style('display','none');
+
+      enrichr_section
+        .append('text')
+        .text('Send genes to ');
+
+      enrichr_section
+        .append('a')
+        .html('Enrichr')
+        .on('click', function(){
+
+          var group_string = d3.select(inst_root + ' .dendro_text input').attr('value');
+
+          // replace all instances of commas with new line
+          var gene_list = group_string.replace(/, /g, '\n');
+
+          ///////////////
+          // clean list
+          ///////////////
+          var enrichr_info = {list: gene_list, description: 'Clustergrammer gene-cluster list' , popup: true};
+
+          // defined globally - will improve
+          send_to_Enrichr(enrichr_info);
+
+        });
+
+    }
+
+  }
+
+}
+
+function check_gene_request(inst_cgm, gene_symbol, run_ini_enrichr){
+
+  if (gene_symbol.indexOf(' ') > 0){
+    gene_symbol = gene_symbol.split(' ')[0];
+  } else if (gene_symbol.indexOf('_') > 0){
+    gene_symbol = gene_symbol.split('_')[0];
+  }
+
+
+  var base_url = 'https://amp.pharm.mssm.edu/Harmonizome/api/1.0/gene/';
+  var url = base_url + gene_symbol;
+
+  if (genes_were_found[inst_cgm.params.root] === false){
+
+    // make sure value is non-numeric
+    if (isNaN(gene_symbol)){
+
+      $.get(url, function(data) {
+
+        data = JSON.parse(data);
+
+        if (data.name != undefined){
+          genes_were_found[inst_cgm.params.root] = true;
+        }
+
+        run_ini_enrichr(inst_cgm, gene_symbol);
+
+      });
+
+    }
+  }
+
+}
+
+function Enrichrgram(inst_cgm){
+
+  var inst_root = inst_cgm.params.root;
+
+  function enrichr_icon(){
+
+    var low_opacity = 0.7;
+    var high_opacity = 1.0;
+    var icon_size = 42;
+    var d3_tip_custom = inst_cgm.d3_tip_custom();
+
+    // var enrichr_description = 'Perform enrichment analysis on your gene-list <br>'+
+    //                           'using Enrichr to find biological information that is unique to your list.'
+    var enrichr_description = 'Perform enrichment analysis, using Enrichr, to find biological <br>'+
+                              'information specific to your set (or subset) of genes. <br><br>' +
+                              'Select a subset of genes for analysis by cropping the matrix using: the brush-cropping tool in the sidebar, or the crop buttons on the dendrogram.'
+    // d3-tooltip
+    var enr_tip = d3_tip_custom()
+      .attr('class', function(){
+        var root_tip_selector = inst_cgm.params.viz.root_tips.replace('.','');
+        var class_string = root_tip_selector + '_enr_tip d3-tip';
+        return class_string;
+      })
+      .direction('se')
+      .style('display', 'none')
+      .offset([-10,-5])
+      .html(function(d){
+        return enrichr_description;
+      });
+
+    var enr_logo = d3.select(inst_root+' .viz_svg').append("svg:image")
+     .attr('x', 50)
+     .attr('y', 2)
+     .attr('width', icon_size)
+     .attr('height', icon_size)
+     .attr("xlink:href", "https://amp.pharm.mssm.edu/Enrichr/images/enrichr-icon.png")
+     .style('opacity', low_opacity)
+     .classed('enrichr_logo', true)
+     .attr('id', function(){
+      var inst_id = 'enrichr_menu_button_' + inst_cgm.params.root.replace('#','');
+      return inst_id;
+     })
+     .on('click', function(){
+       toggle_enrichr_menu();
+     })
+     .on('mouseover', function(){
+
+      var is_showing = d3.select(inst_cgm.params.root+' .enrichr_menu')
+                         .classed('showing');
+
+      if (is_showing === false){
+        // show tooltip
+        d3.selectAll( inst_cgm.params.viz.root_tips + '_enr_tip')
+          .style('opacity', 1)
+          .style('display', 'block');
+
+         enr_tip.show();
+      }
+
+     })
+     .on('mouseout', function(){
+
+      // hide tooltip
+      d3.selectAll( inst_cgm.params.viz.root_tips + '_enr_tip')
+        .style('opacity', 0)
+        .style('display', 'block');
+
+       enr_tip.hide();
+     })
+     .call(enr_tip);
+
+    var enr_menu = d3.select(inst_cgm.params.root+' .viz_svg')
+      .append('g')
+      .classed('showing', false)
+      .classed('enrichr_menu', true)
+      .attr('transform', 'translate(85,40)')
+      .style('display', 'none');
+
+    enr_menu
+      .append('rect')
+      .classed('enr_menu_background', true)
+      .attr('width', 475)
+      .attr('height', 500)
+      .attr('opacity', 0.95)
+      .attr('fill', 'white')
+      .attr('stroke', '#A3A3A3')
+      .attr('stroke-width', '3px');
+
+    enr_menu
+      .append('text')
+      .attr('transform', 'translate(20,30)')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif')
+      .attr('font-size','18px')
+      .attr('font-weight', 800)
+      .attr('cursor', 'default')
+      .text('Choose Enrichr Library');
+
+    // clear results button
+    enr_menu
+      .append('text')
+      .classed('enr_menu_clear', true)
+      .attr('transform', 'translate(345, 30)')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif')
+      .style('font-size','18px')
+      .style('font-weight', 800)
+      .style('cursor', 'default')
+      .text('Clear Results')
+      .style('fill', 'red')
+      .style('opacity', 0.75)
+      .style('display', 'none')
+      .on('click', function(){
+
+
+        // reset enrichr menu
+        toggle_enrichr_menu();
+
+        // clear enrichr results and run resizing
+        clear_enrichr_results(true);
+
+      })
+
+    var lib_section = enr_menu
+      .append('g')
+      .attr('transform', 'translate(20,60)')
+      .style('width', 460)
+      .style('height', 370)
+      .classed('enr_lib_section','true');
+
+    var possible_libraries = [
+      'ChEA_2016',
+      'KEA_2015',
+      'ENCODE_TF_ChIP-seq_2015',
+      'ENCODE_Histone_Modifications_2015',
+      'Disease_Perturbations_from_GEO_up',
+      'Disease_Perturbations_from_GEO_down',
+      'GO_Molecular_Function_2015',
+      'GO_Biological_Process_2015',
+      'GO_Cellular_Component_2015',
+      'Reactome_2016',
+      'KEGG_2016',
+      'MGI_Mammalian_Phenotype_Level_4',
+      'LINCS_L1000_Chem_Pert_up',
+      'LINCS_L1000_Chem_Pert_down',
+      ];
+
+    var vertical_space = 30;
+
+    enr_menu
+      .append('rect')
+      .classed('enr_menu_line', true)
+      .attr('height', '2px')
+      .attr('width', '435px')
+      .style('stroke-width', '3px')
+      .style('opacity', 0.3)
+      .style('fill','black')
+      .attr('transform', 'translate(20, 465)');
+
+    var enr_export_container = enr_menu
+      .append('g')
+      .classed('enr_export_container', true)
+      .attr('transform', 'translate(20, 487)');
+
+    enr_export_container
+      .append('text')
+      .style('font-size','16px')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif')
+      .style('cursor', 'default')
+      .text('Export gene list to ');
+
+    enr_export_container
+      .append('text')
+      .style('font-size','16px')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif')
+      .style('cursor', 'default')
+      .text('Enrichr')
+      .style('fill','#337ab7')
+      .attr('transform', 'translate(135, 0)')
+      .on('click', function(){
+
+        // get gene list and send to Enrichr
+        var gene_list = inst_cgm.params.network_data.row_nodes_names.join('\n');
+
+        var enrichr_info = {list: gene_list, description: 'Clustergrammer gene list' , popup: true};
+
+        // defined globally - will improve
+        enrich(enrichr_info);
+
+      })
+
+    var lib_groups = lib_section
+      .selectAll('g')
+      .data(possible_libraries)
+      .enter()
+      .append('g')
+      .attr('transform', function(d,i){
+        var vert =  i*vertical_space
+        var transform_string = 'translate(0,'+ vert+')';
+        return transform_string;
+      })
+
+    lib_groups
+      .append('circle')
+      .attr('cx', 10)
+      .attr('cy', -6)
+      .attr('r', 7)
+      .style('stroke', '#A3A3A3')
+      .style('stroke-width', '2px')
+      .style('fill','white')
+
+    lib_groups
+      .append('text')
+      .attr('transform', 'translate(25,0)')
+      .style('font-size','16px')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif')
+      .style('cursor', 'default')
+      .text(function(d){
+        return d.replace(/_/g, ' ');
+      });
+
+    lib_groups
+      .on('click', function(d){
+
+        d3.select(inst_cgm.params.root+' .enr_lib_section')
+          .selectAll('g')
+          .select('circle')
+          .style('fill','white');
+
+        // indicate that library was selected
+        d3.select(this)
+          .select('circle')
+          .style('fill','red')
+
+        // turn on clear sign
+        d3.select(inst_cgm.params.root+' .enr_menu_clear')
+          .transition()
+          .delay(1000)
+          .style('display', 'block');
+
+        // request enrichment results from Enrichr
+        enr_obj.enrichr_rows(d, update_viz_callback, 10);
+
+        make_enr_wait_circle();
+        animate_wait();
+
+        setTimeout(toggle_enrichr_menu, 500);
+      })
+
+  }
+
+  function clear_enrichr_results(run_resize_viz){
+
+    d3.select(inst_cgm.params.root+ ' .enr_menu_clear')
+      .style('display', 'none');
+
+    // unselect library
+    d3.select(inst_cgm.params.root+' .enr_lib_section')
+      .selectAll('g')
+      .select('circle')
+      .style('fill','white');
+
+    // clear categories
+    inst_cgm.reset_cats(run_resize_viz);
+
+    // remove title and bars
+    d3.select(inst_cgm.params.root+' .enr_title').remove();
+    d3.selectAll(inst_cgm.params.root+' .enrichr_bars').remove();
+
+  }
+
+  function toggle_enrichr_menu(){
+
+    var enr_menu = d3.select(inst_cgm.params.root+' .enrichr_menu');
+
+    if (enr_menu.classed('showing') === false){
+
+      // show menu
+      ///////////////////////
+      enr_menu
+        .classed('showing', true)
+        .style('display', 'block');
+
+      d3.select(inst_cgm.params.root+' .enrichr_menu')
+        .style('opacity',0)
+        .transition()
+        .style('opacity',1)
+
+      d3.selectAll('.row_cat_super').style('display','none');
+
+      // hide tooltip
+      d3.selectAll( inst_cgm.params.viz.root_tips + '_enr_tip')
+        .style('opacity', 0)
+        .style('display', 'none');
+
+    } else {
+
+      // hide menu
+      ///////////////////////
+      setTimeout(function(){enr_menu.style('display', 'none');}, 1000)
+
+      d3.select(inst_cgm.params.root+' .enrichr_menu')
+        .classed('showing', false)
+        .style('opacity',1)
+        .transition()
+        .style('opacity',0)
+
+      d3.selectAll('.row_cat_super').style('display','block');
+    }
+
+  }
+
+  function get_enr_with_list(ini_gene_list, library, callback_function){
+
+    // clean gene list
+    var gene_list = []
+    _.each(ini_gene_list, function(gene_symbol){
+      if (gene_symbol.indexOf(' ') > 0){
+        gene_symbol = gene_symbol.split(' ')[0];
+      } else if (gene_symbol.indexOf('_') > 0){
+        gene_symbol = gene_symbol.split('_')[0];
+      }
+      gene_list.push(gene_symbol)
+    })
+
+    enr_obj.library = library;
+    enr_obj.gene_list = gene_list;
+
+    enr_obj.post_list(gene_list, function(){
+
+      if (typeof callback_function != 'undefined'){
+        enr_obj.get_enr(library, callback_function);
+      } else {
+        enr_obj.get_enr(library);
+      }
+
+    });
+  }
+
+  function post_list(gene_list, callback_function){
+
+    var gene_list_string = gene_list.join('\n');
+
+    var form = new FormData();
+    var response;
+
+    form.append("list", gene_list_string);
+
+    form.append("description", "clustergrammer");
+
+    var settings = {
+     "async": true,
+     "crossDomain": true,
+     "url": "https://amp.pharm.mssm.edu/Enrichr/addList",
+     "method": "POST",
+     "processData": false,
+     "contentType": false,
+     "mimeType": "multipart/form-data",
+     "data": form
+    }
+
+    if (typeof callback_function === 'undefined'){
+      callback_function = confirm_save;
+    }
+
+    $.ajax(settings)
+     .done(function(response){
+      response = JSON.parse(response);
+      enr_obj.user_list_id = response.userListId;
+
+      // make get request
+      setTimeout(callback_function, 500, response);
+      // callback_function(response);
+     });
+  }
+
+  function confirm_save(response){
+    console.log('saved user_list_id '+String(enr_obj.user_list_id));
+  }
+
+  function get_enr(library, callback_function){
+
+    if (enr_obj.user_list_id !== null){
+      var form = new FormData();
+
+      var base_url = 'https://amp.pharm.mssm.edu/Enrichr/enrich?';
+      var library_string = 'backgroundType=' + String(library);
+      var list_id_string = 'userListId=' + String(enr_obj.user_list_id);
+
+      var full_url = base_url + library_string + '&' + list_id_string;
+
+      // get request
+      var settings = {
+       "async": true,
+       "crossDomain": true,
+       "url": full_url,
+       "method": "GET",
+       "processData": false,
+       "contentType": false,
+       "mimeType": "multipart/form-data",
+       "data": form
+      }
+
+      $.ajax(settings)
+        .done(function (response, textStatus, jqXHR) {
+
+          response = JSON.parse(response);
+          enr_obj.enr_data = response;
+
+          // parse enr_data to cat_data format
+          /////////////////////////////////////
+          // enr_obj.cat_data = enr_obj.enr_data
+          enr_obj.enr_data_to_cats();
+
+          if (typeof callback_function != 'undefined'){
+            callback_function(enr_obj);
+          }
+          d3.select(inst_cgm.params.root+' .enr_wait_circle').remove();
+
+        })
+        .fail(function( jqXHR, textStatus, errorThrown ){
+
+          enr_obj.get_tries = enr_obj.get_tries + 1;
+
+          if (enr_obj.get_tries < 2){
+            // enr_obj.get_enr(library, callback_function);
+            setTimeout( enr_obj.get_enr, 500, library_string, callback_function )
+          } else {
+            console.log('did not get response from Enrichr - need to remove wait circle')
+            d3.select(inst_cgm.params.root+' .enr_wait_circle').remove();
+          }
+
+        });
+
+    } else {
+      console.log('no user_list_id defined')
+    }
+  }
+
+  function enrichr_rows(library, callback_function, num_terms){
+
+    // set up a variable number of terms
+
+    enr_obj.library = library;
+    var gene_list = inst_cgm.params.network_data.row_nodes_names;
+    enr_obj.get_enr_with_list(gene_list, library, callback_function)
+
+  }
+
+  function enr_data_to_cats(){
+
+    var library_name = _.keys(this.enr_data)[0];
+
+    var enr_terms = this.enr_data[library_name];
+
+    // keep the top 10 enriched terms
+    enr_terms = enr_terms.slice(0,10);
+
+    cat_data = []
+
+    _.each(enr_terms, function(inst_term){
+
+      inst_data = {};
+      inst_data['cat_title'] = inst_term[1];
+      inst_data['cats'] = [];
+      inst_data['pval'] = inst_term[2];
+
+      // keep the combined score
+      inst_data['combined_score'] = inst_term[4]
+
+      cat_details = {};
+      cat_details.cat_name = 'true';
+      cat_details.members = inst_term[5]
+
+      // there are only two categories for Enrichr: true/false
+      inst_data['cats'].push(cat_details)
+
+      cat_data.push(inst_data);
+    });
+
+    this.cat_data = cat_data;
+
+  }
+
+  function animate_wait() {
+
+    var repeat_time = 700;
+    var max_opacity = 0.8;
+    var min_opacity = 0.2
+
+    d3.select(inst_cgm.params.root+' .enr_wait_circle')
+      .transition()
+      .ease('linear')
+      .style('opacity', min_opacity)
+      .transition()
+      .ease('linear')
+      .duration(repeat_time)
+      .style('opacity', max_opacity)
+      .transition()
+      .ease('linear')
+      .duration(repeat_time)
+      .style('opacity', min_opacity)
+      .each("end", animate_wait);
+  }
+
+  function update_viz_callback(enr_obj){
+
+    inst_cgm.update_cats(enr_obj.cat_data);
+
+    // Enrichrgram title
+    ////////////////////
+    d3.select(inst_cgm.params.root+' .enr_title').remove();
+
+    var enr_title = d3.select(inst_cgm.params.root+' .viz_svg')
+      .append('g')
+      .classed('enr_title', true)
+      .attr('transform', function(){
+
+        var trans = d3.select(inst_cgm.params.root+' .row_cat_label_container')
+                      .attr('transform').split('(')[1].split(')')[0];
+        x_offset = Number(trans.split(',')[0]) - 10;
+
+        return 'translate('+ String(x_offset)+', 0)';
+
+      });
+
+    enr_title
+      .append('rect')
+      .attr('width', inst_cgm.params.viz.cat_room.row)
+      .attr('height', 25)
+      .attr('fill', 'white');
+
+    var library_string = enr_obj.library.substring(0,40);
+    enr_title
+      .append('text')
+      .attr('transform', 'translate(0, 17)')
+      .text(library_string.replace(/_/g, ' '))
+      .style('font-size', '15px')
+      .attr('font-family', '"Helvetica Neue", Helvetica, Arial, sans-serif');
+
+    var extra_y_room = 1.25;
+    var unit_length = extra_y_room * inst_cgm.params.viz.cat_room.symbol_width;
+    var bar_width = unit_length * 0.9;
+
+    // Enrichr bars
+    ///////////////////////////////
+    d3.selectAll(inst_cgm.params.root+' .enrichr_bars').remove();
+
+    var bar_height = inst_cgm.params.viz.clust.margin.top - 35;
+    var max_score = enr_obj.cat_data[0].combined_score;
+    var bar_scale = d3.scale.linear()
+                      .domain([0, max_score])
+                      .range([0, bar_height]);
+
+    d3.select(inst_cgm.params.root+' .row_cat_label_bar_container')
+      .selectAll()
+      .data(inst_cgm.params.viz.all_cats.row)
+      .enter()
+      .append('rect')
+      .classed('enrichr_bars', true)
+      .attr('height', bar_width +'px')
+      .attr('fill', 'red')
+      .attr('width', function(d){
+        var enr_index = d.split('-')[1];
+        var inst_comb_score = enr_obj.cat_data[enr_index].combined_score;
+        var bar_lenth = bar_scale(inst_comb_score);
+        var bar_length_string = bar_lenth + 'px'
+        return bar_length_string;
+      })
+      .attr('opacity', 0.4)
+      .attr('transform', function(d){
+        var inst_y = unit_length * (parseInt( d.split('-')[1], 10 ) -0.75 );
+        return 'translate(0,'+inst_y+')';
+      });
+
+  }
+
+  function make_enr_wait_circle(){
+    var pos_x = 72;
+    var pos_y = 25;
+
+     var click_circle = d3.select(inst_cgm.params.root+' .viz_svg')
+        .append('circle')
+        .classed('enr_wait_circle', true)
+        .attr('cx',pos_x)
+        .attr('cy',pos_y)
+        .attr('r',23)
+        .style('stroke','#666666')
+        .style('stroke-width','3px')
+        .style('fill','white')
+        .style('fill-opacity',0)
+        .style('opacity', 0);
+  }
+
+  // example of how to check gene list
+  // http://amp.pharm.mssm.edu/Enrichr/view?userListId=1284420
+
+  var enr_obj = {};
+  enr_obj.user_list_id = null;
+  enr_obj.enr_data = null;
+  enr_obj.cat_data = null;
+  enr_obj.get_tries = 0;
+  enr_obj.library = null;
+  enr_obj.gene_list = null;
+
+  enr_obj.enrichr_icon = enrichr_icon;
+  enr_obj.post_list = post_list;
+  enr_obj.get_enr = get_enr;
+  enr_obj.get_enr_with_list = get_enr_with_list;
+  enr_obj.enrichr_rows = enrichr_rows;
+  enr_obj.enr_data_to_cats = enr_data_to_cats;
+  enr_obj.update_viz_callback = update_viz_callback;
+  enr_obj.clear_enrichr_results = clear_enrichr_results;
+
+  return enr_obj;
+
+}