openphar 0.1.0

data/shapes/monograph-shapes.ttl

@@ -0,0 +1,1324 @@
+# Open Pharmacopoeia - SHACL Shapes for Monograph Validation
+#
+# This file defines SHACL shapes for validating pharmacopoeia monograph data.
+# Ensures that all required properties are present and have correct types.
+
+@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
+@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
+@prefix owl: <http://www.w3.org/2002/07/owl#> .
+@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
+@prefix skos: <http://www.w3.org/2004/02/skos/core#> .
+@prefix sh: <http://www.w3.org/ns/shacl#> .
+@prefix op: <https://www.openphar.org/ontology/core/> .
+@prefix shape: <https://www.openphar.org/shapes/> .
+
+<https://www.openphar.org/shapes/monograph-shapes>
+    a owl:Ontology ;
+    rdfs:label "Open Pharmacopoeia Monograph Shapes"@en ;
+    rdfs:comment "SHACL shapes for validating pharmacopoeia monographs."@en ;
+    owl:imports <https://www.openphar.org/ontology/core> ;
+    sh:declare [
+        sh:prefix "op" ;
+        sh:namespace "https://www.openphar.org/ontology/core/"^^xsd:anyURI
+    ] , [
+        sh:prefix "skos" ;
+        sh:namespace "http://www.w3.org/2004/02/skos/core#"^^xsd:anyURI
+    ] .
+
+# =============================================================================
+# PHARMACOPOEIA MONOGRAPH SHAPE
+# =============================================================================
+
+shape:PharmacopoeiaMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:PharmacopoeiaMonograph ;
+
+    # Required properties
+    sh:property [
+        sh:path op:publisher ;
+        sh:class op:Publisher ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A monograph must have exactly one publisher."@en
+    ] ;
+
+    sh:property [
+        sh:path op:monographId ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A monograph must have exactly one monograph ID."@en
+    ] ;
+
+    sh:property [
+        sh:path skos:prefLabel ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:message "A monograph must have at least one preferred label."@en
+    ] ;
+
+    # Optional but recommended properties
+    sh:property [
+        sh:path op:status ;
+        sh:class op:MonographStatus ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A monograph should have a status."@en
+    ] ;
+
+    sh:property [
+        sh:path op:effectiveDate ;
+        sh:datatype xsd:date ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may have an effective date."@en
+    ] ;
+
+    sh:property [
+        sh:path op:version ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may have a version."@en
+    ] ;
+
+    # External references
+    sh:property [
+        sh:path op:referencesPreparation ;
+        sh:nodeKind sh:IRI ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A monograph should reference a HerbalPreparation in data-herbapedia."@en
+    ] ;
+
+    sh:property [
+        sh:path op:referencesTCMProfile ;
+        sh:nodeKind sh:IRI ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may reference a TCMProfile in data-herbapedia."@en
+    ] ;
+
+    sh:property [
+        sh:path op:referencesAyurvedaProfile ;
+        sh:nodeKind sh:IRI ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may reference an AyurvedaProfile in data-herbapedia."@en
+    ] ;
+
+    sh:property [
+        sh:path op:referencesWesternProfile ;
+        sh:nodeKind sh:IRI ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may reference a WesternProfile in data-herbapedia."@en
+    ] ;
+
+    # Definition
+    sh:property [
+        sh:path op:definition ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A monograph should have a definition."@en
+    ] ;
+
+    # Test specifications
+    sh:property [
+        sh:path op:testSpecification ;
+        sh:class op:TestSpecification ;
+        sh:node shape:TestSpecificationShape ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may have test specifications."@en
+    ] ;
+
+    # Storage
+    sh:property [
+        sh:path op:storageContainer ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may specify storage container requirements."@en
+    ] ;
+
+    sh:property [
+        sh:path op:storageConditions ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A monograph may specify storage conditions."@en
+    ] .
+
+# =============================================================================
+# CRUDE DRUG MONOGRAPH SHAPE
+# =============================================================================
+
+shape:CrudeDrugMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:CrudeDrugMonograph ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    # Additional required properties for crude drugs
+    sh:property [
+        sh:path op:botanicalSource ;
+        sh:class op:BotanicalSource ;
+        sh:minCount 1 ;
+        sh:node shape:BotanicalSourceShape ;
+        sh:message "A crude drug monograph must have at least one botanical source."@en
+    ] ;
+
+    sh:property [
+        sh:path op:macroscopicDescription ;
+        sh:class op:MacroscopicDescription ;
+        sh:node shape:MacroscopicDescriptionShape ;
+        sh:severity sh:Warning ;
+        sh:message "A crude drug monograph should have a macroscopic description."@en
+    ] ;
+
+    sh:property [
+        sh:path op:microscopicDescription ;
+        sh:class op:MicroscopicDescription ;
+        sh:node shape:MicroscopicDescriptionShape ;
+        sh:severity sh:Warning ;
+        sh:message "A crude drug monograph should have a microscopic description."@en
+    ] .
+
+# =============================================================================
+# TEST SPECIFICATION SHAPE
+# =============================================================================
+
+shape:TestSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:TestSpecification ;
+
+    sh:property [
+        sh:path op:testName ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A test specification must have exactly one test name."@en
+    ] ;
+
+    sh:property [
+        sh:path op:testType ;
+        sh:class op:TestType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A test specification must have exactly one test type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:harmonizedMethod ;
+        sh:class op:HarmonizedMethod ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A test specification may reference a harmonized method."@en
+    ] ;
+
+    sh:property [
+        sh:path op:publisherMethod ;
+        sh:class op:PublisherMethod ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A test specification may reference a publisher method."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:node shape:LimitShape ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A test specification may have a limit."@en
+    ] .
+
+# =============================================================================
+# ASSAY SPECIFICATION SHAPE
+# =============================================================================
+
+shape:AssaySpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:AssaySpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:assayTarget ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An assay specification must specify the assay target."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:minCount 1 ;
+        sh:node shape:LimitShape ;
+        sh:message "An assay specification must have a limit."@en
+    ] .
+
+# =============================================================================
+# LIMIT SHAPE
+# =============================================================================
+
+shape:LimitShape
+    a sh:NodeShape ;
+    sh:targetClass op:Limit ;
+
+    sh:property [
+        sh:path op:limitType ;
+        sh:class op:LimitType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A limit must have exactly one limit type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limitUnit ;
+        sh:class op:Unit ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A limit must have exactly one unit."@en
+    ] ;
+
+    # For simple limits (min, max, exact)
+    sh:property [
+        sh:path op:limitValue ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:message "A limit may have a single limit value."@en
+    ] ;
+
+    # For range limits
+    sh:property [
+        sh:path op:lowerLimit ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:message "A limit may have a lower bound."@en
+    ] ;
+
+    sh:property [
+        sh:path op:upperLimit ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:message "A limit may have an upper bound."@en
+    ] .
+
+# =============================================================================
+# BOTANICAL SOURCE SHAPE
+# =============================================================================
+
+shape:BotanicalSourceShape
+    a sh:NodeShape ;
+    sh:targetClass op:BotanicalSource ;
+
+    sh:property [
+        sh:path op:referencesPlantSpecies ;
+        sh:nodeKind sh:IRI ;
+        sh:minCount 1 ;
+        sh:message "A botanical source must reference a PlantSpecies in data-herbapedia."@en
+    ] ;
+
+    sh:property [
+        sh:path op:plantPartUsed ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A botanical source must specify the plant part used."@en
+    ] ;
+
+    sh:property [
+        sh:path op:collectionPeriod ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A botanical source may specify the collection period."@en
+    ] .
+
+# =============================================================================
+# MACROSCOPIC DESCRIPTION SHAPE
+# =============================================================================
+
+shape:MacroscopicDescriptionShape
+    a sh:NodeShape ;
+    sh:targetClass op:MacroscopicDescription ;
+
+    sh:property [
+        sh:path op:color ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A macroscopic description should specify the color."@en
+    ] ;
+
+    sh:property [
+        sh:path op:shape ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A macroscopic description should specify the shape."@en
+    ] ;
+
+    sh:property [
+        sh:path op:size ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A macroscopic description may specify the size."@en
+    ] ;
+
+    sh:property [
+        sh:path op:texture ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A macroscopic description may specify the texture."@en
+    ] ;
+
+    sh:property [
+        sh:path op:odor ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A macroscopic description may specify the odor."@en
+    ] ;
+
+    sh:property [
+        sh:path op:taste ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A macroscopic description may specify the taste."@en
+    ] ;
+
+    sh:property [
+        sh:path op:fracture ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A macroscopic description may specify the fracture."@en
+    ] .
+
+# =============================================================================
+# MICROSCOPIC DESCRIPTION SHAPE
+# =============================================================================
+
+shape:MicroscopicDescriptionShape
+    a sh:NodeShape ;
+    sh:targetClass op:MicroscopicDescription ;
+
+    sh:property [
+        sh:path op:transverseSection ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A microscopic description may specify transverse section features."@en
+    ] ;
+
+    sh:property [
+        sh:path op:powderCharacteristics ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A microscopic description may specify powder characteristics."@en
+    ] ;
+
+    sh:property [
+        sh:path op:diagnosticFeatures ;
+        sh:datatype rdf:langString ;
+        sh:severity sh:Info ;
+        sh:message "A microscopic description may specify diagnostic features."@en
+    ] .
+
+# =============================================================================
+# PUBLISHER METHOD SHAPE
+# =============================================================================
+
+shape:PublisherMethodShape
+    a sh:NodeShape ;
+    sh:targetClass op:PublisherMethod ;
+
+    sh:property [
+        sh:path skos:prefLabel ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A publisher method must have a preferred label."@en
+    ] ;
+
+    sh:property [
+        sh:path op:methodPublisher ;
+        sh:class op:Publisher ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A publisher method must specify its publisher."@en
+    ] ;
+
+    sh:property [
+        sh:path op:equivalentTo ;
+        sh:class op:HarmonizedMethod ;
+        sh:severity sh:Info ;
+        sh:message "A publisher method may be equivalent to a harmonized method."@en
+    ] .
+
+# =============================================================================
+# CHEMICAL DRUG MONOGRAPH SHAPE
+# =============================================================================
+
+shape:ChemicalDrugMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:ChemicalDrugMonograph ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    # Required chemical identification properties
+    sh:property [
+        sh:path op:molecularFormula ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A chemical drug monograph must have exactly one molecular formula."@en
+    ] ;
+
+    sh:property [
+        sh:path op:molecularWeight ;
+        sh:datatype xsd:decimal ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A chemical drug monograph must have exactly one molecular weight."@en
+    ] ;
+
+    sh:property [
+        sh:path op:casNumber ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A chemical drug monograph must have exactly one CAS Registry Number."@en
+    ] ;
+
+    # Optional but recommended chemical properties
+    sh:property [
+        sh:path op:systematicName ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A chemical drug monograph should have a systematic (IUPAC) name."@en
+    ] ;
+
+    sh:property [
+        sh:path op:chemicalStructure ;
+        sh:datatype xsd:anyURI ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A chemical drug monograph may reference a chemical structure (InChI, SMILES, etc.)."@en
+    ] ;
+
+    sh:property [
+        sh:path op:inchi ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A chemical drug monograph may have an InChI identifier."@en
+    ] ;
+
+    sh:property [
+        sh:path op:inchiKey ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A chemical drug monograph may have an InChIKey."@en
+    ] ;
+
+    sh:property [
+        sh:path op:smiles ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A chemical drug monograph may have a SMILES notation."@en
+    ] .
+
+# =============================================================================
+# VITAMIN MONOGRAPH SHAPE
+# =============================================================================
+
+shape:VitaminMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:VitaminMonograph ;
+
+    # Inherits all constraints from ChemicalDrugMonograph
+    sh:and ( shape:ChemicalDrugMonographShape ) ;
+
+    # Vitamin-specific properties
+    sh:property [
+        sh:path op:vitaminType ;
+        sh:class op:VitaminType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A vitamin monograph must specify its vitamin type (e.g., Vitamin C, Vitamin D)."@en
+    ] ;
+
+    sh:property [
+        sh:path op:biologicalActivity ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A vitamin monograph may specify biological activity in IU."@en
+    ] .
+
+# =============================================================================
+# AMINO ACID MONOGRAPH SHAPE
+# =============================================================================
+
+shape:AminoAcidMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:AminoAcidMonograph ;
+
+    # Inherits all constraints from ChemicalDrugMonograph
+    sh:and ( shape:ChemicalDrugMonographShape ) ;
+
+    # Amino acid-specific properties
+    sh:property [
+        sh:path op:aminoAcidType ;
+        sh:class op:AminoAcidType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An amino acid monograph must specify its amino acid type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:essentialAminoAcid ;
+        sh:datatype xsd:boolean ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An amino acid monograph may indicate if it is essential."@en
+    ] ;
+
+    sh:property [
+        sh:path op:stereochemistry ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "An amino acid monograph should specify stereochemistry (L, D, DL)."@en
+    ] .
+
+# =============================================================================
+# MINERAL SUBSTANCE MONOGRAPH SHAPE
+# =============================================================================
+
+shape:MineralSubstanceMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:MineralSubstanceMonograph ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    # Required mineral identification properties
+    sh:property [
+        sh:path op:mineralFormula ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A mineral substance monograph must have a chemical formula."@en
+    ] ;
+
+    sh:property [
+        sh:path op:mineralType ;
+        sh:class op:MineralType ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A mineral substance monograph should specify its mineral type."@en
+    ] ;
+
+    # Mineral-specific properties
+    sh:property [
+        sh:path op:mineralSource ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A mineral substance monograph may specify the natural source."@en
+    ] ;
+
+    sh:property [
+        sh:path op:elementalComposition ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A mineral substance monograph may specify elemental composition."@en
+    ] .
+
+# =============================================================================
+# BIOLOGICAL SUBSTANCE MONOGRAPH SHAPE
+# =============================================================================
+
+shape:BiologicalSubstanceMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:BiologicalSubstanceMonograph ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    # Required biological identification properties
+    sh:property [
+        sh:path op:biologicalSourceType ;
+        sh:class op:BiologicalSourceType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A biological substance monograph must specify its biological source type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:biologicalOrigin ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A biological substance monograph should specify biological origin (animal, plant, microbial)."@en
+    ] ;
+
+    # Biological-specific properties
+    sh:property [
+        sh:path op:activityUnit ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A biological substance monograph should specify activity units (e.g., Units/mg)."@en
+    ] ;
+
+    sh:property [
+        sh:path op:sourceOrganism ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A biological substance monograph may specify the source organism."@en
+    ] .
+
+# =============================================================================
+# ENZYME PREPARATION MONOGRAPH SHAPE
+# =============================================================================
+
+shape:EnzymePreparationMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:EnzymePreparationMonograph ;
+
+    # Inherits all constraints from BiologicalSubstanceMonograph
+    sh:and ( shape:BiologicalSubstanceMonographShape ) ;
+
+    # Enzyme-specific properties
+    sh:property [
+        sh:path op:enzymeCommissionNumber ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An enzyme preparation monograph must have an EC number."@en
+    ] ;
+
+    sh:property [
+        sh:path op:enzymeActivity ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An enzyme preparation monograph must specify enzyme activity."@en
+    ] ;
+
+    sh:property [
+        sh:path op:optimalPH ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An enzyme preparation monograph may specify optimal pH."@en
+    ] ;
+
+    sh:property [
+        sh:path op:optimalTemperature ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An enzyme preparation monograph may specify optimal temperature."@en
+    ] .
+
+# =============================================================================
+# HORMONE PREPARATION MONOGRAPH SHAPE
+# =============================================================================
+
+shape:HormonePreparationMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:HormonePreparationMonograph ;
+
+    # Inherits all constraints from BiologicalSubstanceMonograph
+    sh:and ( shape:BiologicalSubstanceMonographShape ) ;
+
+    # Hormone-specific properties
+    sh:property [
+        sh:path op:hormoneType ;
+        sh:class op:HormoneType ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A hormone preparation monograph must specify its hormone type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:biologicalPotency ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A hormone preparation monograph should specify biological potency."@en
+    ] .
+
+# =============================================================================
+# FORMULATION MONOGRAPH SHAPE
+# =============================================================================
+
+shape:FormulationMonographShape
+    a sh:NodeShape ;
+    sh:targetClass op:FormulationMonograph ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    # Required formulation properties
+    sh:property [
+        sh:path op:dosageForm ;
+        sh:class op:DosageForm ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A formulation monograph must have exactly one dosage form."@en
+    ] ;
+
+    sh:property [
+        sh:path op:hasComponent ;
+        sh:class op:FormulationComponent ;
+        sh:minCount 1 ;
+        sh:node shape:FormulationComponentShape ;
+        sh:message "A formulation monograph must have at least one component."@en
+    ] ;
+
+    # Optional formulation properties
+    sh:property [
+        sh:path op:routeOfAdministration ;
+        sh:class op:RouteOfAdministration ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A formulation monograph should specify route of administration."@en
+    ] ;
+
+    sh:property [
+        sh:path op:packSize ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A formulation monograph may specify pack size."@en
+    ] ;
+
+    sh:property [
+        sh:path op:shelfLife ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A formulation monograph may specify shelf life."@en
+    ] .
+
+# =============================================================================
+# FORMULATION COMPONENT SHAPE
+# =============================================================================
+
+shape:FormulationComponentShape
+    a sh:NodeShape ;
+    sh:targetClass op:FormulationComponent ;
+
+    # Required component properties
+    sh:property [
+        sh:path op:componentSubstance ;
+        sh:datatype xsd:anyURI ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A formulation component must reference exactly one substance."@en
+    ] ;
+
+    sh:property [
+        sh:path op:componentRole ;
+        sh:class op:ComponentRole ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A formulation component must have exactly one role."@en
+    ] ;
+
+    # Component quantity (required for active ingredients)
+    sh:property [
+        sh:path op:componentQuantity ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A formulation component should specify quantity."@en
+    ] ;
+
+    sh:property [
+        sh:path op:componentUnit ;
+        sh:class op:Unit ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A formulation component may specify quantity unit."@en
+    ] ;
+
+    # Optional component properties
+    sh:property [
+        sh:path op:componentStrength ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A formulation component may specify strength (e.g., '500 mg per tablet')."@en
+    ] ;
+
+    sh:property [
+        sh:path op:componentPercentage ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A formulation component may specify percentage in formulation."@en
+    ] .
+
+# =============================================================================
+# MELTING POINT SPECIFICATION SHAPE
+# =============================================================================
+
+shape:MeltingPointSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:MeltingPointSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:meltingPointRange ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A melting point specification must specify a temperature range."@en
+    ] ;
+
+    sh:property [
+        sh:path op:temperatureUnit ;
+        sh:class op:TemperatureUnit ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A melting point specification should specify temperature unit."@en
+    ] .
+
+# =============================================================================
+# SPECIFIC ROTATION SPECIFICATION SHAPE
+# =============================================================================
+
+shape:SpecificRotationSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:SpecificRotationSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:rotationRange ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A specific rotation specification must specify a rotation range."@en
+    ] ;
+
+    sh:property [
+        sh:path op:measurementConditions ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A specific rotation specification should specify measurement conditions (temperature, wavelength, solvent)."@en
+    ] .
+
+# =============================================================================
+# LOSS ON DRYING SPECIFICATION SHAPE
+# =============================================================================
+
+shape:LossOnDryingSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:LossOnDryingSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:dryingConditions ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A loss on drying specification must specify drying conditions."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:minCount 1 ;
+        sh:node shape:LimitShape ;
+        sh:message "A loss on drying specification must have a limit."@en
+    ] .
+
+# =============================================================================
+# RESIDUE ON IGNITION SPECIFICATION SHAPE
+# =============================================================================
+
+shape:ResidueOnIgnitionSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:ResidueOnIgnitionSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:ignitionConditions ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A residue on ignition specification must specify ignition conditions."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:minCount 1 ;
+        sh:node shape:LimitShape ;
+        sh:message "A residue on ignition specification must have a limit."@en
+    ] .
+
+# =============================================================================
+# PH SPECIFICATION SHAPE
+# =============================================================================
+
+shape:PHSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:PHSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:phRange ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A pH specification must specify a pH range."@en
+    ] ;
+
+    sh:property [
+        sh:path op:solutionConditions ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A pH specification should specify solution conditions (concentration, solvent)."@en
+    ] .
+
+# =============================================================================
+# DISSOLUTION SPECIFICATION SHAPE
+# =============================================================================
+
+shape:DissolutionSpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:DissolutionSpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:dissolutionMedium ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A dissolution specification must specify the dissolution medium."@en
+    ] ;
+
+    sh:property [
+        sh:path op:dissolutionApparatus ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A dissolution specification must specify the apparatus type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:dissolutionTime ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A dissolution specification must specify time points."@en
+    ] ;
+
+    sh:property [
+        sh:path op:dissolutionLimit ;
+        sh:datatype xsd:string ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A dissolution specification must specify the dissolution limit (Q value)."@en
+    ] .
+
+# =============================================================================
+# CONTENT UNIFORMITY SPECIFICATION SHAPE
+# =============================================================================
+
+shape:ContentUniformitySpecificationShape
+    a sh:NodeShape ;
+    sh:targetClass op:ContentUniformitySpecification ;
+
+    sh:and ( shape:TestSpecificationShape ) ;
+
+    sh:property [
+        sh:path op:acceptanceValue ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A content uniformity specification should specify acceptance value (AV)."@en
+    ] ;
+
+    sh:property [
+        sh:path op:referenceMethod ;
+        sh:class op:HarmonizedMethod ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A content uniformity specification may reference a harmonized method."@en
+    ] .
+
+# =============================================================================
+# TEST CLASS HIERARCHY SHAPES (from data-japan-pharmacopia)
+# =============================================================================
+
+shape:TestShape
+    a sh:NodeShape ;
+    sh:targetClass op:Test ;
+
+    sh:property [
+        sh:path op:testName ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A test must have exactly one test name."@en
+    ] ;
+
+    sh:property [
+        sh:path op:usesTestMethod ;
+        sh:class op:HarmonizedMethod ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "A test may reference a harmonized method."@en
+    ] ;
+
+    sh:property [
+        sh:path op:testDescription ;
+        sh:datatype rdf:langString ;
+        sh:severity sh:Info ;
+        sh:message "A test may have a description of the test procedure."@en
+    ] .
+
+shape:IdentificationTestShape
+    a sh:NodeShape ;
+    sh:targetClass op:IdentificationTest ;
+
+    sh:and ( shape:TestShape ) ;
+
+    sh:property [
+        sh:path op:identificationMethod ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "An identification test should specify the method (e.g., TLC, UV, IR)."@en
+    ] ;
+
+    sh:property [
+        sh:path op:expectedResult ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "An identification test should specify the expected result."@en
+    ] .
+
+shape:PurityTestShape
+    a sh:NodeShape ;
+    sh:targetClass op:PurityTest ;
+
+    sh:and ( shape:TestShape ) ;
+
+    sh:property [
+        sh:path op:impurityType ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A purity test must specify the impurity type."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A purity test should have a limit."@en
+    ] .
+
+shape:LimitTestShape
+    a sh:NodeShape ;
+    sh:targetClass op:LimitTest ;
+
+    sh:and ( shape:TestShape ) ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A limit test must have a limit."@en
+    ] .
+
+shape:AssayTestShape
+    a sh:NodeShape ;
+    sh:targetClass op:AssayTest ;
+
+    sh:and ( shape:TestShape ) ;
+
+    sh:property [
+        sh:path op:assayTarget ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An assay test must specify the target compound or parameter."@en
+    ] ;
+
+    sh:property [
+        sh:path op:limit ;
+        sh:class op:Limit ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An assay test must have a limit."@en
+    ] .
+
+# =============================================================================
+# PREPARATION METHOD SHAPE (from data-japan-pharmacopia)
+# =============================================================================
+
+shape:PreparationMethodShape
+    a sh:NodeShape ;
+    sh:targetClass op:PreparationMethod ;
+
+    sh:property [
+        sh:path op:methodLabel ;
+        sh:datatype rdf:langString ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A preparation method must have a label."@en
+    ] ;
+
+    sh:property [
+        sh:path op:methodDescription ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "A preparation method should have a description."@en
+    ] ;
+
+    sh:property [
+        sh:path op:hasIngredientItem ;
+        sh:class op:Ingredient ;
+        sh:minCount 1 ;
+        sh:node shape:IngredientShape ;
+        sh:message "A preparation method must have at least one ingredient."@en
+    ] .
+
+# =============================================================================
+# INGREDIENT SHAPE (from data-japan-pharmacopia)
+# =============================================================================
+
+shape:IngredientShape
+    a sh:NodeShape ;
+    sh:targetClass op:Ingredient ;
+
+    sh:property [
+        sh:path op:usesCrudeDrug ;
+        sh:class op:CrudeDrugMonograph ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An ingredient must reference exactly one crude drug."@en
+    ] ;
+
+    sh:property [
+        sh:path op:ingredientAmount ;
+        sh:datatype xsd:decimal ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "An ingredient must have an amount."@en
+    ] ;
+
+    sh:property [
+        sh:path op:ingredientAmountUnit ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Warning ;
+        sh:message "An ingredient should have an amount unit."@en
+    ] ;
+
+    sh:property [
+        sh:path op:ingredientRatio ;
+        sh:datatype xsd:decimal ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An ingredient may have a ratio in the formula."@en
+    ] .
+
+# =============================================================================
+# POWDERED CRUDE DRUG SHAPE (from data-japan-pharmacopia)
+# =============================================================================
+
+shape:PowderedCrudeDrugShape
+    a sh:NodeShape ;
+    sh:targetClass op:PowderedCrudeDrug ;
+
+    # Inherits all constraints from CrudeDrugMonograph
+    sh:and ( shape:CrudeDrugMonographShape ) ;
+
+    sh:property [
+        sh:path op:isPowderedFormOf ;
+        sh:class op:CrudeDrugMonograph ;
+        sh:minCount 1 ;
+        sh:maxCount 1 ;
+        sh:message "A powdered crude drug must reference its source crude drug."@en
+    ] .
+
+# =============================================================================
+# EXTRACT SHAPE (with preparation method support)
+# =============================================================================
+
+shape:ExtractShape
+    a sh:NodeShape ;
+    sh:targetClass op:Extract ;
+
+    # Inherits all constraints from PharmacopoeiaMonograph
+    sh:and ( shape:PharmacopoeiaMonographShape ) ;
+
+    sh:property [
+        sh:path op:extractionRatio ;
+        sh:datatype xsd:string ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An extract may have an extraction ratio."@en
+    ] ;
+
+    sh:property [
+        sh:path op:extractionSolvent ;
+        sh:datatype rdf:langString ;
+        sh:maxCount 1 ;
+        sh:severity sh:Info ;
+        sh:message "An extract may specify the extraction solvent."@en
+    ] ;
+
+    sh:property [
+        sh:path op:hasPreparationMethod ;
+        sh:class op:PreparationMethod ;
+        sh:maxCount 1 ;
+        sh:node shape:PreparationMethodShape ;
+        sh:severity sh:Warning ;
+        sh:message "An extract should have a preparation method."@en
+    ] ;
+
+    sh:property [
+        sh:path op:hasIngredient ;
+        sh:class op:CrudeDrugMonograph ;
+        sh:severity sh:Info ;
+        sh:message "An extract may have ingredients (for multi-herb extracts)."@en
+    ] .