cell_cycle 0.0.3 → 0.1.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- checksums.yaml +4 -4
- data/lib/cell_cycle/simple.rb +2 -3
- data/lib/cell_cycle/version.rb +3 -1
- data/lib/cell_cycle/virginia_tech.rb +26 -43
- data/lib/cell_cycle.rb +14 -3
- metadata +1 -1
checksums.yaml
CHANGED
@@ -1,7 +1,7 @@
|
|
1
1
|
---
|
2
2
|
SHA1:
|
3
|
-
metadata.gz:
|
4
|
-
data.tar.gz:
|
3
|
+
metadata.gz: 16fa9dd102f38e28071366b53da9752f8e332785
|
4
|
+
data.tar.gz: 49cc905bc4a42fcaef78c882d3082567ef3fa705
|
5
5
|
SHA512:
|
6
|
-
metadata.gz:
|
7
|
-
data.tar.gz:
|
6
|
+
metadata.gz: 22047cc300354bc3a0f0c5f018dfd442ba53583069e9d3c34c1d0a78e181580d7ea54e8076d8f5b10496876577a9fb35c729d80e071cd840db1c1b596c5a4f18
|
7
|
+
data.tar.gz: 4550945464c1112d256248333203cdbd46e6b2611ec84c61e6de3a98674120accf441944690ef276bf73b72ba0e8594ac7e240af22e6f7b134b4295216de4bec
|
data/lib/cell_cycle/simple.rb
CHANGED
@@ -6,8 +6,7 @@
|
|
6
6
|
# phase. Cdc20A represents the APC (Anaphase Promoting Complex). When present,
|
7
7
|
# it degrades the cell cycle enzyme machinery.
|
8
8
|
|
9
|
-
require '
|
10
|
-
require 'sy'
|
9
|
+
require 'cell_cycle'
|
11
10
|
|
12
11
|
# Constants that control the cell cycle settings.
|
13
12
|
S_phase_duration = 12.h
|
@@ -50,7 +49,7 @@ S_phase = Place m!: 0
|
|
50
49
|
Cdc20A = Place m!: 1
|
51
50
|
|
52
51
|
# Include them in the CELL_CYCLE net.
|
53
|
-
CELL_CYCLE
|
52
|
+
CELL_CYCLE << Timer << Clock << A_phase << S_phase << Cdc20A
|
54
53
|
|
55
54
|
# Assignment transitions that control the state of the places A_phase, S_phase
|
56
55
|
# and Cdc20A.
|
data/lib/cell_cycle/version.rb
CHANGED
@@ -3,7 +3,7 @@
|
|
3
3
|
# Generic cell cycle published in Csikasznagy2006agm. Mammalian constants used.
|
4
4
|
# Initial state was obtained as described in Csikasznagy2006agm.
|
5
5
|
|
6
|
-
require '
|
6
|
+
require 'cell_cycle'
|
7
7
|
|
8
8
|
# == TRICKS =====================================================================
|
9
9
|
|
@@ -419,52 +419,35 @@ finalize # YNelson command that finishes the net from the prescribed commands.
|
|
419
419
|
# ==============================================================================
|
420
420
|
|
421
421
|
|
422
|
+
CELL_CYCLE.merge! net # This is quite fragile, since it assumes that no places
|
423
|
+
# and/or transitions have been created before requiring
|
424
|
+
# the cell cycle gem.
|
422
425
|
|
423
426
|
|
427
|
+
# Net that defines cell growth, to be used eg. for testing or separate use.
|
428
|
+
CELL_GROWTH_NET = Net()
|
429
|
+
CELL_GROWTH_NET << Mass << Cell_growth << CycD <<
|
430
|
+
transition( :CycD_ϝ ) << CycB << ActCycB << # cyclin B
|
431
|
+
Ck_license << Cytokinesis << License_cocking # cytokinesis
|
424
432
|
|
433
|
+
# cell growth
|
434
|
+
def CELL_CYCLE.default_simulation
|
435
|
+
simulation time: 0..96.h.in( :s ),
|
436
|
+
step: 5,
|
437
|
+
sampling: 300
|
438
|
+
# FIXME: This method #default_simulation doesn't work, and I don't know why,
|
439
|
+
# while standard way of simulation works. I can just use the standard way
|
440
|
+
# of simulation by simply calling run! command, and fix this later.
|
441
|
+
end
|
425
442
|
|
426
|
-
|
427
|
-
|
428
|
-
|
429
|
-
|
430
|
-
|
431
|
-
|
432
|
-
|
433
|
-
|
434
|
-
|
435
|
-
|
436
|
-
|
437
|
-
|
438
|
-
=begin
|
439
|
-
|
440
|
-
# === Whole CELL_CYCLE Nelson net ===
|
441
|
-
|
442
|
-
CELL_CYCLE = Net() << A_phase << S_phase << Cdc20A
|
443
|
-
|
444
|
-
# === Cell growh net ===
|
445
|
-
|
446
|
-
CELL_GROWTH_NET = Net() <<
|
447
|
-
Mass << Cell_growth << CycD << transition( :CycD_ϝ ) << # cell growth
|
448
|
-
CycB << ActCycB << # cyclin B
|
449
|
-
Ck_license << Cytokinesis << License_cocking # cytokinesis
|
450
|
-
|
451
|
-
set_step 5 # simulation settings
|
443
|
+
set_step 5
|
444
|
+
set_target_time 96.h.in( :s )
|
452
445
|
set_sampling 300
|
453
|
-
set_target_time 3600 * 24 * 4
|
454
|
-
|
455
|
-
new_simulation
|
456
|
-
|
457
|
-
|
458
|
-
pm # prints marking of the newly created simulation
|
459
|
-
simulation.step! # peforms a single simulation step
|
460
|
-
pm # prints marking again
|
461
|
-
|
462
|
-
# simulation.run! upto: 3600 # we can run 1 hour of this simulation
|
463
|
-
|
464
|
-
recording.plot # and plot the recording
|
465
446
|
|
466
|
-
#
|
467
|
-
#
|
468
|
-
#
|
447
|
+
# I commented this out, I don't really want to run this lengthy simulation upon
|
448
|
+
# requiring the gem.
|
449
|
+
# run!
|
469
450
|
|
470
|
-
|
451
|
+
# Note: Possible things to do with the recording, such as resampling, feature
|
452
|
+
# extraction, saving to a file, reconstruction of a new simulation object at
|
453
|
+
# a given time etc.
|
data/lib/cell_cycle.rb
CHANGED
@@ -1,5 +1,16 @@
|
|
1
1
|
# encoding: utf-8
|
2
2
|
|
3
|
-
#
|
4
|
-
#
|
5
|
-
|
3
|
+
# Mammalian cell cycle model. 2 versions available at the moment,
|
4
|
+
# 'cell_cycle/simple' and 'cell_cycle/virginia_tech'. This is the
|
5
|
+
# common 'cell_cycle.rb' file.
|
6
|
+
|
7
|
+
# Require dependencies.
|
8
|
+
require 'sy'
|
9
|
+
require 'y_nelson' and include YNelson
|
10
|
+
|
11
|
+
# Define the empty CELL_CYCLE net (its contents is to be added by
|
12
|
+
# the particular implemented cell cycle types).
|
13
|
+
CELL_CYCLE = Net()
|
14
|
+
|
15
|
+
# Cell cycle version.
|
16
|
+
require_relative "cell_cycle/version"
|