bio 1.4.1 → 1.4.2

data/lib/bio/util/restriction_enzyme/range/sequence_range/calculated_cuts.rb

@@ -34,13 +34,40 @@ class CalculatedCuts
   include StringFormatting
 
   # +Array+ of vertical cuts on the primary strand in 0-based index notation
-  attr_reader :vc_primary
+  def vc_primary
+    #$stderr.puts caller[0].inspect ###DEBUG
+    @vc_primary.to_a
+  end
+
+  # Returns the same contents as vc_primary, but returns original data
+  # structure used in the class.
+  def vc_primary_as_original_class
+    @vc_primary
+  end
   
   # +Array+ of vertical cuts on the complementary strand in 0-based index notation
-  attr_reader :vc_complement
+  def vc_complement
+    #$stderr.puts caller[0].inspect ###DEBUG
+    @vc_complement.to_a
+  end
+
+  # Returns the same contents as vc_complement, but returns original data
+  # structure used in the class.
+  def vc_complement_as_original_class
+    @vc_complement
+  end
 
   # +Array+ of horizontal cuts between strands in 0-based index notation
-  attr_reader :hc_between_strands
+  def hc_between_strands
+    #$stderr.puts caller[0].inspect ###DEBUG
+    @hc_between_strands.to_a
+  end
+
+  # Returns the same contents as hc_between_strands, but returns original data
+  # structure used in the class.
+  def hc_between_strands_as_original_class
+    @hc_between_strands
+  end
 
   # Set to +true+ if the fragment CalculatedCuts is working on is circular
   attr_accessor :circular
@@ -60,9 +87,9 @@ class CalculatedCuts
   def initialize(size=nil, circular=false)
     @size = size
     @circular = circular
-    @vc_primary = []
-    @vc_complement = []
-    @hc_between_strands = []
+    @vc_primary = SortedNumArray[]
+    @vc_complement = SortedNumArray[]
+    @hc_between_strands = SortedNumArray[]
   end
 
   # Accepts an +Array+ of CutRange type objects and applies them to 
@@ -75,9 +102,12 @@ class CalculatedCuts
   def add_cuts_from_cut_ranges(cut_ranges)
     @strands_for_display_current = false
 
+    @vc_primary = @vc_primary.dup
+    @vc_complement = @vc_complement.dup
+
     cut_ranges.each do |cut_range|
-      @vc_primary += [cut_range.p_cut_left, cut_range.p_cut_right]
-      @vc_complement += [cut_range.c_cut_left, cut_range.c_cut_right]
+      @vc_primary.concat [cut_range.p_cut_left, cut_range.p_cut_right]
+      @vc_complement.concat [cut_range.c_cut_left, cut_range.c_cut_right]
 
       # Add horizontal cut ranges.  This may happen from cuts made inbetween a
       # VerticalCutRange or may be specifically defined by a HorizontalCutRange.
@@ -124,10 +154,10 @@ class CalculatedCuts
     @size = size if size
     raise IndexError, "Size of the strand must be provided here or during initalization." if !@size.kind_of?(Fixnum) and not @circular
 
-    vcuts = (@vc_primary + @vc_complement).uniq.sort
+    vcuts = @vc_primary + @vc_complement
     hcuts = @hc_between_strands
     last_index = @size - 1
-    good_hcuts = []
+    good_hcuts = SortedNumArray[]
     potential_hcuts = []
 
     if @circular
@@ -146,13 +176,14 @@ class CalculatedCuts
 
       if potential_hcuts.empty?
         if vcuts.include?( hcut ) and vcuts.include?( hcut - 1 )
-          good_hcuts += [hcut]
+          good_hcuts << hcut
         elsif vcuts.include?( hcut - 1 )
           potential_hcuts << hcut
         end
       else
         if vcuts.include?( hcut )
-          good_hcuts += potential_hcuts + [hcut]
+          good_hcuts.concat(potential_hcuts)
+          good_hcuts << hcut
           potential_hcuts.clear
         else
           potential_hcuts << hcut
@@ -163,7 +194,7 @@ class CalculatedCuts
     check_vc = lambda do |vertical_cuts, opposing_vcuts|
       # opposing_vcuts is here only to check for blunt cuts, so there shouldn't
       # be any out-of-order problems with this
-      good_vc = []
+      good_vc = SortedNumArray[]
       vertical_cuts.each { |vc| good_vc << vc if good_hcuts.include?( vc ) or good_hcuts.include?( vc + 1 ) or opposing_vcuts.include?( vc ) }
       good_vc
     end
@@ -192,18 +223,26 @@ class CalculatedCuts
     hcs = '-'   # Horizontal cut symbol
     vhcs = '+'  # Intersection of vertical and horizontal cut symbol
       
-    num_txt_repeat = lambda { num_txt = '0123456789'; (num_txt * ( @size / num_txt.size.to_f ).ceil)[0..@size-1] }
+    num_txt_repeat = lambda { num_txt = '0123456789'; (num_txt * (@size.div(num_txt.size) + 1))[0..@size-1] }
     (str1 == nil) ? a = num_txt_repeat.call : a = str1.dup
     (str2 == nil) ? b = num_txt_repeat.call : b = str2.dup
 
+    if vcp and !vcp.is_a?(SortedNumArray) then
+      vcp = SortedNumArray.new.concat(vcp)
+    end
+    if vcc and !vcc.is_a?(SortedNumArray) then
+      vcc = SortedNumArray.new.concat(vcc)
+    end
+    if hc and !hc.is_a?(SortedNumArray) then
+      hc = SortedNumArray.new.concat(hc)
+    end
+
     vcp = @vc_primary if vcp==nil
     vcc = @vc_complement if vcc==nil
     hc = @hc_between_strands if hc==nil
 
-    vcuts = (vcp + vcc).uniq.sort
-
-    vcp.reverse.each { |c| a.insert(c+1, vcs) }
-    vcc.reverse.each { |c| b.insert(c+1, vcs) }
+    vcp.reverse_each { |c| a.insert(c+1, vcs) }
+    vcc.reverse_each { |c| b.insert(c+1, vcs) }
 
     between = ' ' * @size
     hc.each {|hcut| between[hcut,1] = hcs }

data/lib/bio/util/restriction_enzyme/range/sequence_range/fragment.rb

@@ -5,7 +5,7 @@
 # Copyright:: Copyright (c) 2005-2007 Midwinter Laboratories, LLC (http://midwinterlabs.com)
 # License::   The Ruby License
 #
-#  $Id: fragment.rb,v 1.6 2007/07/16 19:28:48 k Exp $
+#  $Id:$
 #
 
 require 'bio/util/restriction_enzyme'
@@ -31,7 +31,7 @@ class Fragment
     df.primary = ''
     df.complement = ''
 
-    both_bins = (@primary_bin + @complement_bin).sort.uniq
+    both_bins = @primary_bin + @complement_bin
     both_bins.each do |item|
       @primary_bin.include?(item) ? df.primary << p_str[item] : df.primary << ' '
       @complement_bin.include?(item) ? df.complement << c_str[item] : df.complement << ' '

data/lib/bio/util/restriction_enzyme/sorted_num_array.rb

@@ -0,0 +1,219 @@
+#
+# bio/util/restriction_enzyme/sorted_num_array.rb - Internal data storage for Bio::RestrictionEnzyme::Range::SequenceRange
+#
+# Copyright::   Copyright (C) 2011
+#               Naohisa Goto <ng@bioruby.org>
+# License::     The Ruby License
+#
+
+module Bio
+class RestrictionEnzyme
+
+  # a class to store sorted numerics.
+  #
+  # Bio::RestrictionEnzyme internal use only.
+  # Please do not create the instance outside Bio::RestrictionEnzyme.
+  class SortedNumArray
+
+    # Same usage as Array.[]
+    def self.[](*args)
+      a = self.new
+      args.each do |elem|
+        a.push elem
+      end
+      a
+    end
+
+    # Creates a new object
+    def initialize
+      @hash = {}
+      #clear_cache
+    end
+
+    # initialize copy
+    def initialize_copy(other)
+      super(other)
+      @hash = @hash.dup
+    end
+
+    # sets internal hash object
+    def internal_data_hash=(h)
+      #clear_cache
+      @hash = h
+      self
+    end
+    protected :internal_data_hash=
+
+    # gets internal hash object
+    def internal_data_hash
+      @hash
+    end
+    protected :internal_data_hash
+
+    #---
+    ## clear the internal cache
+    #def clear_cache
+    #  @sorted_keys = nil
+    #end
+    #protected :clear_cache
+    #+++
+
+    # sorted keys
+    def sorted_keys
+      #@sorted_keys ||= @hash.keys.sort
+      #@sorted_keys
+      @hash.keys.sort
+    end
+    private :sorted_keys
+
+    # adds a new element
+    def push_element(n)
+      #return if @hash.has_key?(n) #already existed; do nothing
+      @hash.store(n, true)
+      #if @sorted_keys then
+      #  if thelast = @sorted_keys[-1] and n > thelast then
+      #    @sorted_keys.push n
+      #  else
+      #    clear_cache
+      #  end
+      #end
+      nil
+    end
+    private :push_element
+
+    # adds a new element in the beginning of the array 
+    def unshift_element(n)
+      #return if @hash.has_key?(n) #already existed; do nothing
+      @hash.store(n, true)
+      #if @sorted_keys then
+      #  if thefirst = @sorted_keys[0] and n < thefirst then
+      #    @sorted_keys.unshift n
+      #  else
+      #    clear_cache
+      #  end
+      #end
+      nil
+    end
+    private :unshift_element
+
+    # Same usage as Array#[]
+    def [](*arg)
+      #$stderr.puts "SortedNumArray#[]"
+      sorted_keys[*arg]
+    end
+
+    # Not implemented
+    def []=(*arg)
+      raise NotImplementedError, 'SortedNumArray#[]= is not implemented.'
+    end
+
+    # Same usage as Array#each
+    def each(&block)
+      sorted_keys.each(&block)
+    end
+
+    # Same usage as Array#reverse_each
+    def reverse_each(&block)
+      sorted_keys.reverse_each(&block)
+    end
+
+    # Same usage as Array#+, but accepts only the same classes instance.
+    def +(other)
+      unless other.is_a?(self.class) then
+        raise TypeError, 'unsupported data type'
+      end
+      new_hash = @hash.merge(other.internal_data_hash)
+      result = self.class.new
+      result.internal_data_hash = new_hash
+      result
+    end
+
+    # Same usage as Array#==
+    def ==(other)
+      if r = super(other) then
+        r
+      elsif other.is_a?(self.class) then
+        other.internal_data_hash == @hash
+      else
+        false
+      end
+    end
+
+    # Same usage as Array#concat
+    def concat(ary)
+      ary.each { |elem| push_element(elem) }
+      self
+    end
+
+    # Same usage as Array#push
+    def push(*args)
+      args.each do |elem|
+        push_element(elem)
+      end
+      self
+    end
+
+    # Same usage as Array#unshift
+    def unshift(*arg)
+      arg.reverse_each do |elem|
+        unshift_element(elem)
+      end
+      self
+    end
+
+    # Same usage as Array#<<
+    def <<(elem)
+      push_element(elem)
+      self
+    end
+
+    # Same usage as Array#include?
+    def include?(elem)
+      @hash.has_key?(elem)
+    end
+
+    # Same usage as Array#first
+    def first
+      sorted_keys.first
+    end
+
+    # Same usage as Array#last
+    def last
+      sorted_keys.last
+    end
+
+    # Same usage as Array#size
+    def size
+      @hash.size
+    end
+    alias length size
+
+    # Same usage as Array#delete
+    def delete(elem)
+      #clear_cache
+      @hash.delete(elem) ? elem : nil
+    end
+
+    # Does nothing
+    def sort!(&block)
+      # does nothing
+      self
+    end
+
+    # Does nothing
+    def uniq!
+      # does nothing
+      self
+    end
+
+    # Converts to an array
+    def to_a
+      #sorted_keys.dup
+      sorted_keys
+    end
+  end #class SortedNumArray
+
+end #class RestrictionEnzyme
+end #module Bio
+
+

data/lib/bio/version.rb

@@ -10,7 +10,7 @@
 module Bio
 
   # BioRuby version (Array containing Integer)
-  BIORUBY_VERSION = [1, 4, 1].extend(Comparable).freeze
+  BIORUBY_VERSION = [1, 4, 2].extend(Comparable).freeze
 
   # Extra version specifier (String or nil).
   # Existance of the value indicates pre-release version or modified version.

data/sample/test_restriction_enzyme_long.rb

@@ -0,0 +1,4403 @@
+#
+# = sample/test_restriction_enzyme_long.rb - Benchmark tests for Bio::RestrictionEnzyme::Analysis.cut for long sequences
+#
+# Copyright::   Copyright (C) 2011
+#               Naohisa Goto <ng@bioruby.org>
+# License::     The Ruby License
+#
+# Acknowledgements: The idea of the test is based on the issue report
+# https://github.com/bioruby/bioruby/issues/10
+# posted by ray1729 (https://github.com/ray1729).
+#
+
+require 'test/unit'
+require 'benchmark'
+require 'bio'
+
+entry = Bio::TogoWS::REST.entry('genbank', 'BA000007.2')
+EcoliO157H7Seq = Bio::GenBank.new(entry).naseq.freeze
+
+module TestRestrictionEnzymeAnalysisCutLong
+
+  # dummy benchmarch class
+  class DummyBench
+    def report(str); yield; end
+  end
+
+  module HelperMethods
+    def _truncate_cut_ranges(cut_ranges, len)
+      limit = len - 1
+      ret = cut_ranges.collect do |a|
+        if a[0] > limit || a[2] > limit then
+          nil
+        else
+          a.collect { |pos| pos > limit ? limit : pos }
+        end
+      end
+      ret.compact!
+      if last_a = ret[-1] then
+        last_a[1] = limit
+        last_a[3] = limit
+      end
+      ret
+    end
+
+    def _collect_cut_ranges(cuts)
+      cuts.collect do |f|
+                [ f.p_left, f.p_right, f.c_left, f.c_right ]
+      end
+    end
+
+    def _test_by_size(len, bench = DummyBench.new)
+      cuts = nil
+      bench.report("#{self.class::TestLabel} #{len}") {
+        cuts = _cut(self.class::SampleSequence[0, len])
+      }
+      cut_ranges = _collect_cut_ranges(cuts)
+      expected = _truncate_cut_ranges(self.class::SampleCutRanges, len)
+      assert_equal(expected, cut_ranges)
+    end
+
+    def test_10k_to_100k
+      $stderr.print "\n"
+      Benchmark.bm(26) do |bench|
+        10_000.step(100_000, 10_000) do |len|
+          _test_by_size(len, bench)
+        end
+      end
+    end
+
+    def test_100k_to_1M
+      $stderr.print "\n"
+      Benchmark.bm(26) do |bench|
+        100_000.step(1_000_000, 100_000) do |len|
+          _test_by_size(len, bench)
+        end
+      end
+    end
+
+    def test_1M_to_5M_and_whole
+      $stderr.print "\n"
+      Benchmark.bm(26) do |bench|
+        1_000_000.step(5_000_000, 1_000_000) do |len|
+          _test_by_size(len, bench)
+        end
+        _test_by_size(self.class::SampleSequence.length, bench)
+      end
+    end if defined? Bio::RestrictionEnzyme::SortedNumArray
+
+    def disabled_test_whole
+      cuts = _cut(self.class::SampleSequence)
+      cut_ranges = _collect_cut_ranges(cuts)
+      cut_ranges.each do |a|
+        $stderr.print "        [ ", a.join(", "), " ], \n"
+      end
+      assert_equal(self.class::SampleCutRanges, cut_ranges)
+    end
+  end #module HelperMethods
+
+
+  class TestEcoliO157H7_BstEII < Test::Unit::TestCase
+
+    include HelperMethods
+
+    TestLabel = 'BstEII'
+
+    SampleSequence = EcoliO157H7Seq
+
+    SampleCutRanges = BstEII_WHOLE =
+      [ [ 0, 79, 0, 84 ], 
+        [ 80, 4612, 85, 4617 ], 
+        [ 4613, 13483, 4618, 13488 ], 
+        [ 13484, 15984, 13489, 15989 ], 
+        [ 15985, 21462, 15990, 21467 ], 
+        [ 21463, 27326, 21468, 27331 ], 
+        [ 27327, 30943, 27332, 30948 ], 
+        [ 30944, 34888, 30949, 34893 ], 
+        [ 34889, 35077, 34894, 35082 ], 
+        [ 35078, 35310, 35083, 35315 ], 
+        [ 35311, 36254, 35316, 36259 ], 
+        [ 36255, 41885, 36260, 41890 ], 
+        [ 41886, 43070, 41891, 43075 ], 
+        [ 43071, 45689, 43076, 45694 ], 
+        [ 45690, 52325, 45695, 52330 ], 
+        [ 52326, 55703, 52331, 55708 ], 
+        [ 55704, 58828, 55709, 58833 ], 
+        [ 58829, 59178, 58834, 59183 ], 
+        [ 59179, 72610, 59184, 72615 ], 
+        [ 72611, 72739, 72616, 72744 ], 
+        [ 72740, 73099, 72745, 73104 ], 
+        [ 73100, 75123, 73105, 75128 ], 
+        [ 75124, 77366, 75129, 77371 ], 
+        [ 77367, 77810, 77372, 77815 ], 
+        [ 77811, 78740, 77816, 78745 ], 
+        [ 78741, 79717, 78746, 79722 ], 
+        [ 79718, 82250, 79723, 82255 ], 
+        [ 82251, 84604, 82256, 84609 ], 
+        [ 84605, 95491, 84610, 95496 ], 
+        [ 95492, 95785, 95497, 95790 ], 
+        [ 95786, 95794, 95791, 95799 ], 
+        [ 95795, 96335, 95800, 96340 ], 
+        [ 96336, 102044, 96341, 102049 ], 
+        [ 102045, 102541, 102050, 102546 ], 
+        [ 102542, 103192, 102547, 103197 ], 
+        [ 103193, 104722, 103198, 104727 ], 
+        [ 104723, 110883, 104728, 110888 ], 
+        [ 110884, 120090, 110889, 120095 ], 
+        [ 120091, 120657, 120096, 120662 ], 
+        [ 120658, 128308, 120663, 128313 ], 
+        [ 128309, 138305, 128314, 138310 ], 
+        [ 138306, 141147, 138311, 141152 ], 
+        [ 141148, 143724, 141153, 143729 ], 
+        [ 143725, 143838, 143730, 143843 ], 
+        [ 143839, 144303, 143844, 144308 ], 
+        [ 144304, 148199, 144309, 148204 ], 
+        [ 148200, 149577, 148205, 149582 ], 
+        [ 149578, 149731, 149583, 149736 ], 
+        [ 149732, 156115, 149737, 156120 ], 
+        [ 156116, 161126, 156121, 161131 ], 
+        [ 161127, 162856, 161132, 162861 ], 
+        [ 162857, 170693, 162862, 170698 ], 
+        [ 170694, 170944, 170699, 170949 ], 
+        [ 170945, 171201, 170950, 171206 ], 
+        [ 171202, 173241, 171207, 173246 ], 
+        [ 173242, 177283, 173247, 177288 ], 
+        [ 177284, 178177, 177289, 178182 ], 
+        [ 178178, 178781, 178183, 178786 ], 
+        [ 178782, 181610, 178787, 181615 ], 
+        [ 181611, 181706, 181616, 181711 ], 
+        [ 181707, 185661, 181712, 185666 ], 
+        [ 185662, 193407, 185667, 193412 ], 
+        [ 193408, 195511, 193413, 195516 ], 
+        [ 195512, 195754, 195517, 195759 ], 
+        [ 195755, 197247, 195760, 197252 ], 
+        [ 197248, 200659, 197253, 200664 ], 
+        [ 200660, 201820, 200665, 201825 ], 
+        [ 201821, 202300, 201826, 202305 ], 
+        [ 202301, 202686, 202306, 202691 ], 
+        [ 202687, 206289, 202692, 206294 ], 
+        [ 206290, 206466, 206295, 206471 ], 
+        [ 206467, 207011, 206472, 207016 ], 
+        [ 207012, 208159, 207017, 208164 ], 
+        [ 208160, 209976, 208165, 209981 ], 
+        [ 209977, 210078, 209982, 210083 ], 
+        [ 210079, 211485, 210084, 211490 ], 
+        [ 211486, 212377, 211491, 212382 ], 
+        [ 212378, 213569, 212383, 213574 ], 
+        [ 213570, 216005, 213575, 216010 ], 
+        [ 216006, 220098, 216011, 220103 ], 
+        [ 220099, 224063, 220104, 224068 ], 
+        [ 224064, 228604, 224069, 228609 ], 
+        [ 228605, 239993, 228610, 239998 ], 
+        [ 239994, 247914, 239999, 247919 ], 
+        [ 247915, 251579, 247920, 251584 ], 
+        [ 251580, 257092, 251585, 257097 ], 
+        [ 257093, 261621, 257098, 261626 ], 
+        [ 261622, 263030, 261627, 263035 ], 
+        [ 263031, 265084, 263036, 265089 ], 
+        [ 265085, 265243, 265090, 265248 ], 
+        [ 265244, 265534, 265249, 265539 ], 
+        [ 265535, 266117, 265540, 266122 ], 
+        [ 266118, 274428, 266123, 274433 ], 
+        [ 274429, 282285, 274434, 282290 ], 
+        [ 282286, 286948, 282291, 286953 ], 
+        [ 286949, 292547, 286954, 292552 ], 
+        [ 292548, 297678, 292553, 297683 ], 
+        [ 297679, 308161, 297684, 308166 ], 
+        [ 308162, 308706, 308167, 308711 ], 
+        [ 308707, 313482, 308712, 313487 ], 
+        [ 313483, 337118, 313488, 337123 ], 
+        [ 337119, 337935, 337124, 337940 ], 
+        [ 337936, 338781, 337941, 338786 ], 
+        [ 338782, 339493, 338787, 339498 ], 
+        [ 339494, 341025, 339499, 341030 ], 
+        [ 341026, 344424, 341031, 344429 ], 
+        [ 344425, 348384, 344430, 348389 ], 
+        [ 348385, 354781, 348390, 354786 ], 
+        [ 354782, 356692, 354787, 356697 ], 
+        [ 356693, 357008, 356698, 357013 ], 
+        [ 357009, 357305, 357014, 357310 ], 
+        [ 357306, 357328, 357311, 357333 ], 
+        [ 357329, 358126, 357334, 358131 ], 
+        [ 358127, 359472, 358132, 359477 ], 
+        [ 359473, 362160, 359478, 362165 ], 
+        [ 362161, 365395, 362166, 365400 ], 
+        [ 365396, 365704, 365401, 365709 ], 
+        [ 365705, 381746, 365710, 381751 ], 
+        [ 381747, 381994, 381752, 381999 ], 
+        [ 381995, 383335, 382000, 383340 ], 
+        [ 383336, 385141, 383341, 385146 ], 
+        [ 385142, 390171, 385147, 390176 ], 
+        [ 390172, 392764, 390177, 392769 ], 
+        [ 392765, 394338, 392770, 394343 ], 
+        [ 394339, 394686, 394344, 394691 ], 
+        [ 394687, 398703, 394692, 398708 ], 
+        [ 398704, 404095, 398709, 404100 ], 
+        [ 404096, 408361, 404101, 408366 ], 
+        [ 408362, 413032, 408367, 413037 ], 
+        [ 413033, 414563, 413038, 414568 ], 
+        [ 414564, 416901, 414569, 416906 ], 
+        [ 416902, 417419, 416907, 417424 ], 
+        [ 417420, 421777, 417425, 421782 ], 
+        [ 421778, 423748, 421783, 423753 ], 
+        [ 423749, 431903, 423754, 431908 ], 
+        [ 431904, 440000, 431909, 440005 ], 
+        [ 440001, 448040, 440006, 448045 ], 
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+        [ 5420217, 5420740, 5420222, 5420745 ], 
+        [ 5420741, 5427477, 5420746, 5427482 ], 
+        [ 5427478, 5429323, 5427483, 5429328 ], 
+        [ 5429324, 5441634, 5429329, 5441639 ], 
+        [ 5441635, 5448663, 5441640, 5448668 ], 
+        [ 5448664, 5452231, 5448669, 5452236 ], 
+        [ 5452232, 5458274, 5452237, 5458279 ], 
+        [ 5458275, 5459524, 5458280, 5459529 ], 
+        [ 5459525, 5468509, 5459530, 5468514 ], 
+        [ 5468510, 5469773, 5468515, 5469778 ], 
+        [ 5469774, 5475379, 5469779, 5475384 ], 
+        [ 5475380, 5476063, 5475385, 5476068 ], 
+        [ 5476064, 5477860, 5476069, 5477865 ], 
+        [ 5477861, 5478124, 5477866, 5478129 ], 
+        [ 5478125, 5478577, 5478130, 5478582 ], 
+        [ 5478578, 5479176, 5478583, 5479181 ], 
+        [ 5479177, 5483012, 5479182, 5483017 ], 
+        [ 5483013, 5483809, 5483018, 5483814 ], 
+        [ 5483810, 5495234, 5483815, 5495239 ], 
+        [ 5495235, 5498449, 5495240, 5498449 ]
+      ]
+
+    def _cut(seq)
+      cuts = Bio::RestrictionEnzyme::Analysis.cut(seq, "BstEII",
+                                                  {:view_ranges => true})
+    end
+
+    def test_BstEII_edge_cases
+      (13481..13492).each do |len|
+        _test_by_size(len)
+      end
+    end
+
+  end # class TestEcoliO157H7_BstEII
+
+  class TestEcoliO157H7_3enzymes < Test::Unit::TestCase
+    include HelperMethods
+
+    TestLabel = 'SacI+EcoRI+BstEII'
+
+    SampleSequence = EcoliO157H7Seq
+
+    
+    SampleCutRanges = The3Enzymes_WHOLE =
+      [ [ 0, 79, 0, 84 ], 
+        [ 80, 3858, 85, 3862 ], 
+        [ 3859, 4612, 3863, 4617 ], 
+        [ 4613, 5619, 4618, 5623 ], 
+        [ 5620, 7472, 5624, 7468 ], 
+        [ 7473, 12905, 7469, 12909 ], 
+        [ 12906, 13483, 12910, 13488 ], 
+        [ 13484, 14551, 13489, 14547 ], 
+        [ 14552, 15984, 14548, 15989 ], 
+        [ 15985, 20045, 15990, 20049 ], 
+        [ 20046, 21462, 20050, 21467 ], 
+        [ 21463, 27326, 21468, 27331 ], 
+        [ 27327, 30943, 27332, 30948 ], 
+        [ 30944, 34888, 30949, 34893 ], 
+        [ 34889, 35077, 34894, 35082 ], 
+        [ 35078, 35310, 35083, 35315 ], 
+        [ 35311, 36254, 35316, 36259 ], 
+        [ 36255, 36648, 36260, 36652 ], 
+        [ 36649, 36918, 36653, 36922 ], 
+        [ 36919, 41885, 36923, 41890 ], 
+        [ 41886, 43070, 41891, 43075 ], 
+        [ 43071, 45689, 43076, 45694 ], 
+        [ 45690, 48588, 45695, 48584 ], 
+        [ 48589, 52325, 48585, 52330 ], 
+        [ 52326, 54650, 52331, 54654 ], 
+        [ 54651, 54728, 54655, 54732 ], 
+        [ 54729, 55703, 54733, 55708 ], 
+        [ 55704, 58828, 55709, 58833 ], 
+        [ 58829, 59178, 58834, 59183 ], 
+        [ 59179, 59800, 59184, 59796 ], 
+        [ 59801, 61256, 59797, 61260 ], 
+        [ 61257, 72610, 61261, 72615 ], 
+        [ 72611, 72739, 72616, 72744 ], 
+        [ 72740, 73099, 72745, 73104 ], 
+        [ 73100, 75123, 73105, 75128 ], 
+        [ 75124, 77366, 75129, 77371 ], 
+        [ 77367, 77810, 77372, 77815 ], 
+        [ 77811, 78740, 77816, 78745 ], 
+        [ 78741, 79717, 78746, 79722 ], 
+        [ 79718, 82250, 79723, 82255 ], 
+        [ 82251, 84604, 82256, 84609 ], 
+        [ 84605, 95491, 84610, 95496 ], 
+        [ 95492, 95785, 95497, 95790 ], 
+        [ 95786, 95794, 95791, 95799 ], 
+        [ 95795, 96335, 95800, 96340 ], 
+        [ 96336, 96489, 96341, 96493 ], 
+        [ 96490, 101464, 96494, 101468 ], 
+        [ 101465, 102044, 101469, 102049 ], 
+        [ 102045, 102541, 102050, 102546 ], 
+        [ 102542, 103192, 102547, 103197 ], 
+        [ 103193, 103397, 103198, 103393 ], 
+        [ 103398, 104722, 103394, 104727 ], 
+        [ 104723, 106365, 104728, 106369 ], 
+        [ 106366, 106896, 106370, 106900 ], 
+        [ 106897, 107735, 106901, 107739 ], 
+        [ 107736, 110020, 107740, 110024 ], 
+        [ 110021, 110883, 110025, 110888 ], 
+        [ 110884, 112524, 110889, 112528 ], 
+        [ 112525, 113324, 112529, 113328 ], 
+        [ 113325, 115867, 113329, 115871 ], 
+        [ 115868, 117723, 115872, 117727 ], 
+        [ 117724, 118742, 117728, 118738 ], 
+        [ 118743, 120090, 118739, 120095 ], 
+        [ 120091, 120657, 120096, 120662 ], 
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+        [ 5157803, 5157970, 5157808, 5157975 ], 
+        [ 5157971, 5160625, 5157976, 5160630 ], 
+        [ 5160626, 5162852, 5160631, 5162857 ], 
+        [ 5162853, 5164824, 5162858, 5164829 ], 
+        [ 5164825, 5171077, 5164830, 5171082 ], 
+        [ 5171078, 5176566, 5171083, 5176570 ], 
+        [ 5176567, 5180104, 5176571, 5180108 ], 
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+        [ 5184143, 5188235, 5184139, 5188240 ], 
+        [ 5188236, 5190430, 5188241, 5190434 ], 
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+        [ 5295146, 5295426, 5295150, 5295431 ], 
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+        [ 5321885, 5327443, 5321890, 5327448 ], 
+        [ 5327444, 5333009, 5327449, 5333014 ], 
+        [ 5333010, 5335558, 5333015, 5335563 ], 
+        [ 5335559, 5337934, 5335564, 5337939 ], 
+        [ 5337935, 5340296, 5337940, 5340301 ], 
+        [ 5340297, 5341322, 5340302, 5341326 ], 
+        [ 5341323, 5342510, 5341327, 5342515 ], 
+        [ 5342511, 5343834, 5342516, 5343839 ], 
+        [ 5343835, 5351733, 5343840, 5351737 ], 
+        [ 5351734, 5355838, 5351738, 5355842 ], 
+        [ 5355839, 5359283, 5355843, 5359288 ], 
+        [ 5359284, 5362430, 5359289, 5362434 ], 
+        [ 5362431, 5362544, 5362435, 5362549 ], 
+        [ 5362545, 5364468, 5362550, 5364472 ], 
+        [ 5364469, 5369245, 5364473, 5369241 ], 
+        [ 5369246, 5375729, 5369242, 5375734 ], 
+        [ 5375730, 5375790, 5375735, 5375795 ], 
+        [ 5375791, 5377253, 5375796, 5377258 ], 
+        [ 5377254, 5378696, 5377259, 5378701 ], 
+        [ 5378697, 5382060, 5378702, 5382065 ], 
+        [ 5382061, 5388003, 5382066, 5388007 ], 
+        [ 5388004, 5388224, 5388008, 5388229 ], 
+        [ 5388225, 5389155, 5388230, 5389159 ], 
+        [ 5389156, 5391633, 5389160, 5391638 ], 
+        [ 5391634, 5399712, 5391639, 5399716 ], 
+        [ 5399713, 5401417, 5399717, 5401422 ], 
+        [ 5401418, 5406297, 5401423, 5406301 ], 
+        [ 5406298, 5406537, 5406302, 5406542 ], 
+        [ 5406538, 5406850, 5406543, 5406854 ], 
+        [ 5406851, 5408637, 5406855, 5408642 ], 
+        [ 5408638, 5410093, 5408643, 5410097 ], 
+        [ 5410094, 5417270, 5410098, 5417275 ], 
+        [ 5417271, 5419353, 5417276, 5419358 ], 
+        [ 5419354, 5420144, 5419359, 5420149 ], 
+        [ 5420145, 5420216, 5420150, 5420221 ], 
+        [ 5420217, 5420740, 5420222, 5420745 ], 
+        [ 5420741, 5423081, 5420746, 5423085 ], 
+        [ 5423082, 5424075, 5423086, 5424079 ], 
+        [ 5424076, 5425137, 5424080, 5425141 ], 
+        [ 5425138, 5427477, 5425142, 5427482 ], 
+        [ 5427478, 5429323, 5427483, 5429328 ], 
+        [ 5429324, 5429631, 5429329, 5429635 ], 
+        [ 5429632, 5432849, 5429636, 5432853 ], 
+        [ 5432850, 5432874, 5432854, 5432878 ], 
+        [ 5432875, 5440584, 5432879, 5440588 ], 
+        [ 5440585, 5440833, 5440589, 5440837 ], 
+        [ 5440834, 5441634, 5440838, 5441639 ], 
+        [ 5441635, 5446602, 5441640, 5446606 ], 
+        [ 5446603, 5448663, 5446607, 5448668 ], 
+        [ 5448664, 5452231, 5448669, 5452236 ], 
+        [ 5452232, 5453350, 5452237, 5453354 ], 
+        [ 5453351, 5455164, 5453355, 5455168 ], 
+        [ 5455165, 5458274, 5455169, 5458279 ], 
+        [ 5458275, 5459524, 5458280, 5459529 ], 
+        [ 5459525, 5468509, 5459530, 5468514 ], 
+        [ 5468510, 5469773, 5468515, 5469778 ], 
+        [ 5469774, 5474040, 5469779, 5474044 ], 
+        [ 5474041, 5475379, 5474045, 5475384 ], 
+        [ 5475380, 5476063, 5475385, 5476068 ], 
+        [ 5476064, 5477860, 5476069, 5477865 ], 
+        [ 5477861, 5478124, 5477866, 5478129 ], 
+        [ 5478125, 5478577, 5478130, 5478582 ], 
+        [ 5478578, 5479176, 5478583, 5479181 ], 
+        [ 5479177, 5483012, 5479182, 5483017 ], 
+        [ 5483013, 5483809, 5483018, 5483814 ], 
+        [ 5483810, 5490967, 5483815, 5490963 ], 
+        [ 5490968, 5491739, 5490964, 5491743 ], 
+        [ 5491740, 5495234, 5491744, 5495239 ], 
+        [ 5495235, 5498449, 5495240, 5498449 ]
+      ]
+
+    def _cut(seq)
+      cuts = Bio::RestrictionEnzyme::Analysis.cut(seq,
+                                                  "SacI", "EcoRI", "BstEII",
+                                                  {:view_ranges => true})
+    end
+  end #TestEcoliO157H7_3enzymes
+
+
+end #module TestRestrictionEnzymeAnalysisCutLong