bento_search 0.0.1
This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
- data/MIT-LICENSE +20 -0
- data/README.md +299 -0
- data/Rakefile +40 -0
- data/app/assets/images/bento_search/large_loader.gif +0 -0
- data/app/assets/javascripts/bento_search.js +3 -0
- data/app/assets/javascripts/bento_search/ajax_load.js +22 -0
- data/app/assets/stylesheets/bento_search/bento.css +4 -0
- data/app/controllers/bento_search/bento_search_controller.rb +7 -0
- data/app/controllers/bento_search/search_controller.rb +72 -0
- data/app/helpers/bento_search_helper.rb +138 -0
- data/app/item_decorators/bento_search/only_premade_openurl.rb +16 -0
- data/app/item_decorators/bento_search/openurl_add_other_link.rb +35 -0
- data/app/item_decorators/bento_search/openurl_main_link.rb +30 -0
- data/app/models/bento_search/author.rb +25 -0
- data/app/models/bento_search/link.rb +30 -0
- data/app/models/bento_search/multi_searcher.rb +109 -0
- data/app/models/bento_search/openurl_creator.rb +128 -0
- data/app/models/bento_search/registrar.rb +70 -0
- data/app/models/bento_search/result_item.rb +203 -0
- data/app/models/bento_search/results.rb +54 -0
- data/app/models/bento_search/results/pagination.rb +67 -0
- data/app/models/bento_search/search_engine.rb +219 -0
- data/app/models/bento_search/search_engine/capabilities.rb +65 -0
- data/app/search_engines/bento_search/#Untitled-1# +11 -0
- data/app/search_engines/bento_search/ebsco_host_engine.rb +356 -0
- data/app/search_engines/bento_search/eds_engine.rb +557 -0
- data/app/search_engines/bento_search/google_books_engine.rb +184 -0
- data/app/search_engines/bento_search/primo_engine.rb +231 -0
- data/app/search_engines/bento_search/scopus_engine.rb +295 -0
- data/app/search_engines/bento_search/summon_engine.rb +398 -0
- data/app/search_engines/bento_search/xerxes_engine.rb +168 -0
- data/app/views/bento_search/_link.html.erb +4 -0
- data/app/views/bento_search/_search_error.html.erb +22 -0
- data/app/views/bento_search/_std_item.html.erb +39 -0
- data/app/views/bento_search/search/search.html.erb +1 -0
- data/config/locales/en.yml +25 -0
- data/lib/bento_search.rb +29 -0
- data/lib/bento_search/engine.rb +5 -0
- data/lib/bento_search/routes.rb +45 -0
- data/lib/bento_search/version.rb +3 -0
- data/lib/generators/bento_search/pull_ebsco_dbs_generator.rb +24 -0
- data/lib/generators/bento_search/templates/ebsco_global_var.erb +6 -0
- data/lib/http_client_patch/include_client.rb +86 -0
- data/lib/tasks/bento_search_tasks.rake +4 -0
- data/test/dummy/README.rdoc +261 -0
- data/test/dummy/Rakefile +7 -0
- data/test/dummy/app/assets/javascripts/application.js +15 -0
- data/test/dummy/app/assets/stylesheets/application.css +13 -0
- data/test/dummy/app/controllers/application_controller.rb +3 -0
- data/test/dummy/app/helpers/application_helper.rb +2 -0
- data/test/dummy/app/views/layouts/application.html.erb +14 -0
- data/test/dummy/config.ru +4 -0
- data/test/dummy/config/application.rb +56 -0
- data/test/dummy/config/boot.rb +10 -0
- data/test/dummy/config/database.yml +25 -0
- data/test/dummy/config/environment.rb +5 -0
- data/test/dummy/config/environments/development.rb +37 -0
- data/test/dummy/config/environments/production.rb +67 -0
- data/test/dummy/config/environments/test.rb +37 -0
- data/test/dummy/config/initializers/backtrace_silencers.rb +7 -0
- data/test/dummy/config/initializers/inflections.rb +15 -0
- data/test/dummy/config/initializers/mime_types.rb +5 -0
- data/test/dummy/config/initializers/secret_token.rb +7 -0
- data/test/dummy/config/initializers/session_store.rb +8 -0
- data/test/dummy/config/initializers/wrap_parameters.rb +14 -0
- data/test/dummy/config/locales/en.yml +5 -0
- data/test/dummy/config/routes.rb +6 -0
- data/test/dummy/db/test.sqlite3 +0 -0
- data/test/dummy/log/test.log +3100 -0
- data/test/dummy/public/404.html +26 -0
- data/test/dummy/public/422.html +26 -0
- data/test/dummy/public/500.html +25 -0
- data/test/dummy/public/favicon.ico +0 -0
- data/test/dummy/script/rails +6 -0
- data/test/functional/bento_search/search_controller_test.rb +81 -0
- data/test/helper/bento_search_helper_test.rb +125 -0
- data/test/integration/navigation_test.rb +10 -0
- data/test/support/mock_engine.rb +23 -0
- data/test/support/test_with_cassette.rb +38 -0
- data/test/test_helper.rb +52 -0
- data/test/unit/#vcr_test.rb# +68 -0
- data/test/unit/ebsco_host_engine_test.rb +134 -0
- data/test/unit/eds_engine_test.rb +105 -0
- data/test/unit/google_books_engine_test.rb +93 -0
- data/test/unit/item_decorators_test.rb +66 -0
- data/test/unit/multi_searcher_test.rb +49 -0
- data/test/unit/openurl_creator_test.rb +111 -0
- data/test/unit/pagination_test.rb +59 -0
- data/test/unit/primo_engine_test.rb +37 -0
- data/test/unit/register_engine_test.rb +50 -0
- data/test/unit/result_item_display_test.rb +39 -0
- data/test/unit/result_item_test.rb +36 -0
- data/test/unit/scopus_engine_test.rb +130 -0
- data/test/unit/search_engine_base_test.rb +178 -0
- data/test/unit/search_engine_test.rb +95 -0
- data/test/unit/summon_engine_test.rb +161 -0
- data/test/unit/xerxes_engine_test.rb +70 -0
- data/test/vcr_cassettes/ebscohost/error_bad_db.yml +45 -0
- data/test/vcr_cassettes/ebscohost/error_bad_password.yml +45 -0
- data/test/vcr_cassettes/ebscohost/get_info.yml +3626 -0
- data/test/vcr_cassettes/ebscohost/live_search.yml +45 -0
- data/test/vcr_cassettes/ebscohost/live_search_smoke_test.yml +1311 -0
- data/test/vcr_cassettes/eds/basic_search_smoke_test.yml +1811 -0
- data/test/vcr_cassettes/eds/get_auth_token.yml +75 -0
- data/test/vcr_cassettes/eds/get_auth_token_failure.yml +39 -0
- data/test/vcr_cassettes/eds/get_with_auth.yml +243 -0
- data/test/vcr_cassettes/eds/get_with_auth_recovers_from_bad_auth.yml +368 -0
- data/test/vcr_cassettes/gbs/error_condition.yml +40 -0
- data/test/vcr_cassettes/gbs/pagination.yml +702 -0
- data/test/vcr_cassettes/gbs/search.yml +340 -0
- data/test/vcr_cassettes/primo/search_smoke_test.yml +1112 -0
- data/test/vcr_cassettes/scopus/bad_api_key_should_return_error_response.yml +60 -0
- data/test/vcr_cassettes/scopus/escaped_chars.yml +187 -0
- data/test/vcr_cassettes/scopus/fielded_search.yml +176 -0
- data/test/vcr_cassettes/scopus/simple_search.yml +227 -0
- data/test/vcr_cassettes/scopus/zero_results_search.yml +67 -0
- data/test/vcr_cassettes/summon/bad_auth.yml +54 -0
- data/test/vcr_cassettes/summon/proper_tags_for_snippets.yml +216 -0
- data/test/vcr_cassettes/summon/search.yml +242 -0
- data/test/vcr_cassettes/xerxes/live_search.yml +2580 -0
- data/test/view/std_item_test.rb +98 -0
- metadata +421 -0
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http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\">\n<title>JHSearch:
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Search Status</title>\n<meta http-equiv=\"refresh\" content=\"6\">\n<base
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language=\"javascript\" type=\"text/javascript\"></script><script type=\"text/javascript\">\n\t\t\t\n\t\t\t//
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change numSessionSavedRecords to numSavedRecords if you prefer the folder
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icon to change\n\t\t\t// if there are any records at all in saved records.
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Also fix initial display in navbar.\n\t\t\t\n\t\t\tnumSavedRecords = parseInt('00',
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10);\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\tisTemporarySession = true;\n\t\t</script><script
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src=\"http://jhsearch.library.jhu.edu/javascript/save.js\" language=\"javascript\"
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type=\"text/javascript\"></script><script language=\"javascript\" type=\"text/javascript\">\n\t\t\tvar
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dateSearch = \"2012-05-22\";\n\t\t\tvar xerxes_iSearchable = \"10\";\n\t\t</script><script
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src=\"http://jhsearch.library.jhu.edu/javascript/collections.js\" language=\"javascript\"
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type=\"text/javascript\"></script><script type=\"text/javascript\">\n\t\t\tvar
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_gaq = _gaq || [];\n\t\t\t_gaq.push(['_setAccount', 'UA-7867593-11']);\n\t\t\t_gaq.push(['_trackPageview']);\n\n\t\t\t(function()
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{\n\t\t\tvar ga = document.createElement('script'); ga.type = 'text/javascript';
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s);\n\t\t\t})();\n\t\t</script>\n</head>\n<body>\n<div class=\"ada\"><a href=\"http://jhsearch.library.jhu.edu/?&base=databases&action=accessible&return=%2Fmetasearch%2Fhits%3Fgroup%3D2012-05-22-000189\">For
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best results, click this link for accessible version</a></div>\n<div id=\"doc3\"
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class=\"yui-t6\">\n<div id=\"hd\">\n<div id=\"my_header\" style=\"background-color:
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style=\"float:right;\">\n<a href=\"/databases/alphabetical\">\n\t\t\t\tDatabase
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List (A-Z)\n </a><a href=\"http://findit.library.jhu.edu\">Journal List
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(A-Z)</a>\n</div>\n<a style=\"color:white\" href=\"http://jhsearch.library.jhu.edu\"><img
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src=\"http://jhsearch.library.jhu.edu/localweb/images/jhsearch-banner.jpg\"
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alt=\"JHSearch\"></a>\n</div>\n<div id=\"breadcrumb\"><div class=\"trail\">\n<a
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href=\"http://jhsearch.library.jhu.edu?\">Home</a> > <a href=\"\">bento_search</a>
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> Search Status</div></div>\n</div>\n<div id=\"bd\">\n<div id=\"yui-main\"><div
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class=\"yui-b\"><div id=\"metasearch_hits\">\n<h1>bento_search</h1>\n<form
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action=\"./\" method=\"get\">\n<input type=\"hidden\" name=\"lang\" value=\"\"><input
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type=\"hidden\" name=\"base\" value=\"metasearch\"><input type=\"hidden\"
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name=\"action\" value=\"search\"><input type=\"hidden\" name=\"context\" value=\"bento_search\"><input
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type=\"hidden\" name=\"context_url\" value=\"\"><div class=\"raisedBox searchBox\">\n<div
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class=\"searchLabel\"><label for=\"field\">Search</label></div>\n<div class=\"searchInputs\">\n<select
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id=\"field\" class=\"field\" name=\"field\"><option value=\"WRD\">all fields</option>\n<option
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value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
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value=\"WSU\">subject</option></select> <label for=\"query\">for</label> <input
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id=\"query\" class=\"query\" name=\"query\" type=\"text\" size=\"32\" value=\"skin
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disease\"><label for=\"find_operator1\" class=\"find_operator1label ada\"
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style=\"display:none;\">Boolean operator: </label> <select id=\"find_operator1\"
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class=\"find_operator1\" name=\"find_operator1\" style=\"display:none;\"><option
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value=\"AND\">And</option>\n<option value=\"OR\">Or</option>\n<option value=\"NOT\">Without</option></select><div
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class=\"searchBox_advanced_newline\" style=\"display:none;\"></div>\n<label
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for=\"field2\" class=\"ada field2label\" style=\"display:none;\">Search</label><span
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class=\"searchBox_advanced_pair\" style=\"display:none;\"><select id=\"field2\"
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class=\"field2\" name=\"field2\"><option value=\"WRD\">all fields</option>\n<option
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value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
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value=\"WSU\">subject</option>\n<option value=\"ISSN\">ISSN</option>\n<option
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value=\"ISBN\">ISBN</option>\n<option value=\"WYR\">year</option></select>
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<label for=\"query2\">for</label> <input id=\"query2\" class=\"query2\" name=\"query2\"
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type=\"text\" size=\"32\" value=\"\"> </span><input class=\"submit_searchbox_\"
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type=\"submit\" name=\"Submit\" value=\"GO\">\n</div>\n<div class=\"metasearch_input_toggle\"><a
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class=\"searchBox_toggle\" href=\"/metasearch/hits?group=2012-05-22-000189&metasearch_input_mode=advanced\">More
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Options</a></div>\n</div>\n<input type=\"hidden\" name=\"database\" value=\"JHU04066\"><input
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type=\"hidden\" name=\"database\" value=\"JHU06614\">\n</form>\n<h2>Search
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Status</h2>\n<div id=\"progress\"><img src=\"images/progress_small1.gif\"
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alt=\"\"></div>\n<table>\n<thead><tr>\n<th>Database</th>\n<th>Status</th>\n<th>Hits</th>\n</tr></thead>\n<tr>\n<td>Academic
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Search Complete</td>\n<td>STARTED</td>\n<td class=\"hitCount\">0</td>\n</tr>\n<tr>\n<td>OmniFile
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Full Text Mega</td>\n<td>STARTED</td>\n<td class=\"hitCount\">0</td>\n</tr>\n</table>\n</div></div></div>\n<div
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class=\"yui-b\"><div id=\"sidebar\">\n<div id=\"account\" class=\"box\">\n<h2>My
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Account</h2>\n<ul>\n<li id=\"login_option\"><a id=\"login\" href=\"https://jhsearch.library.jhu.edu/authenticate/login?return=%2Fmetasearch%2Fhits%3Fgroup%3D2012-05-22-000189\">Log-in</a></li>\n<li
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id=\"my_saved_records\" class=\"sidebarFolder\">\n<img id=\"folder\" name=\"folder\"
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width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"\" src=\"images/folder.gif\">
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<a href=\"/folder?return=%2Fmetasearch%2Fhits%3Fgroup%3D2012-05-22-000189\">My
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Saved Records</a>\n</li>\n<li id=\"my_databases\" class=\"sidebarFolder\">\n<img
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id=\"\" name=\"\" width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"\"
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src=\"images/folder.gif\"> <a href=\"/collections/list\">My Saved Databases</a>\n</li>\n</ul>\n</div>\n<div
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id=\"ft\"><p>JHSearch is a service of the <a href=\"http://webapps.jhu.edu/jhuniverse/libraries/\">Johns
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Also fix initial display in navbar.\n\t\t\t\n\t\t\tnumSavedRecords = parseInt('00',
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disease\"><label for=\"find_operator1\" class=\"find_operator1label ada\"
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style=\"display:none;\">Boolean operator: </label> <select id=\"find_operator1\"
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value=\"AND\">And</option>\n<option value=\"OR\">Or</option>\n<option value=\"NOT\">Without</option></select><div
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class=\"searchBox_advanced_newline\" style=\"display:none;\"></div>\n<label
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for=\"field2\" class=\"ada field2label\" style=\"display:none;\">Search</label><span
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class=\"searchBox_advanced_pair\" style=\"display:none;\"><select id=\"field2\"
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value=\"WSU\">subject</option>\n<option value=\"ISSN\">ISSN</option>\n<option
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value=\"ISBN\">ISBN</option>\n<option value=\"WYR\">year</option></select>
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type=\"text\" size=\"32\" value=\"\"> </span><input class=\"submit_searchbox_\"
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type=\"submit\" name=\"Submit\" value=\"GO\">\n</div>\n<div class=\"metasearch_input_toggle\"><a
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class=\"searchBox_toggle\" href=\"/metasearch/hits?group=2012-05-22-000196&metasearch_input_mode=advanced\">More
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Options</a></div>\n</div>\n<input type=\"hidden\" name=\"database\" value=\"JHU04066\"><input
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type=\"hidden\" name=\"database\" value=\"JHU06614\">\n</form>\n<h2>Search
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Status</h2>\n<div id=\"progress\"><img src=\"images/progress_small1.gif\"
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alt=\"\"></div>\n<table>\n<thead><tr>\n<th>Database</th>\n<th>Status</th>\n<th>Hits</th>\n</tr></thead>\n<tr>\n<td>Academic
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Full Text Mega</td>\n<td>STARTED</td>\n<td class=\"hitCount\">0</td>\n</tr>\n</table>\n</div></div></div>\n<div
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class=\"yui-b\"><div id=\"sidebar\">\n<div id=\"account\" class=\"box\">\n<h2>My
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id=\"my_saved_records\" class=\"sidebarFolder\">\n<img id=\"folder\" name=\"folder\"
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width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"\" src=\"images/folder.gif\">
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Saved Records</a>\n</li>\n<li id=\"my_databases\" class=\"sidebarFolder\">\n<img
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id=\"\" name=\"\" width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"\"
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src=\"images/folder.gif\"> <a href=\"/collections/list\">My Saved Databases</a>\n</li>\n</ul>\n</div>\n<div
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id=\"sessionAuthInfo\" class=\"box\">\n<h2 class=\"sessionLoggedOut\">Welcome</h2>\n<div
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class=\"sessionAuthSection\"></div>\n<div class=\"sessionAuthSection\">\n<h3>Your
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Location: </h3>\n<ul><li>Homewood, SAIS, or Sheridan Library affiliated</li></ul>\n</div>\n</div>\n</div></div>\n</div>\n<div
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id=\"ft\"><p>JHSearch is a service of the <a href=\"http://webapps.jhu.edu/jhuniverse/libraries/\">Johns
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Hopkins Libraries</a>. Powered by <a href=\"http://www.exlibris.co.il/category/MetaLibOverview\">Ex-Libris
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Metalib</a> and the open source <a href=\"http://code.google.com/p/xerxes-portal/\">Xerxes
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project</a>. (Xerxes version 1.7) </p></div>\n</div>\n</body>\n</html>\n"
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\"http://www.w3.org/TR/html4/loose.dtd\">\n<html lang=\"en\">\n<head>\n<meta
|
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+
http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\">\n<title>JHSearch:
|
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Search Status</title>\n<meta http-equiv=\"refresh\" content=\"6\">\n<base
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href=\"http://jhsearch.library.jhu.edu/\">\n<link href=\"http://jhsearch.library.jhu.edu/css/reset-fonts-grids.css?xerxes_version=1.7\"
|
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src=\"http://jhsearch.library.jhu.edu/javascript/onload.js\" language=\"javascript\"
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type=\"text/javascript\"></script><script src=\"http://jhsearch.library.jhu.edu/javascript/prototype.js\"
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language=\"javascript\" type=\"text/javascript\"></script><script src=\"http://jhsearch.library.jhu.edu/javascript/scriptaculous/scriptaculous.js\"
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language=\"javascript\" type=\"text/javascript\"></script><script src=\"http://jhsearch.library.jhu.edu/javascript/message_display.js\"
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|
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language=\"javascript\" type=\"text/javascript\"></script><script src=\"http://jhsearch.library.jhu.edu/javascript/toggle_metasearch_advanced.js\"
|
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+
language=\"javascript\" type=\"text/javascript\"></script><script type=\"text/javascript\">\n\t\t\t\n\t\t\t//
|
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458
|
+
change numSessionSavedRecords to numSavedRecords if you prefer the folder
|
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459
|
+
icon to change\n\t\t\t// if there are any records at all in saved records.
|
|
460
|
+
Also fix initial display in navbar.\n\t\t\t\n\t\t\tnumSavedRecords = parseInt('00',
|
|
461
|
+
10);\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\tisTemporarySession = true;\n\t\t</script><script
|
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src=\"http://jhsearch.library.jhu.edu/javascript/save.js\" language=\"javascript\"
|
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type=\"text/javascript\"></script><script language=\"javascript\" type=\"text/javascript\">\n\t\t\tvar
|
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+
dateSearch = \"2012-05-22\";\n\t\t\tvar xerxes_iSearchable = \"10\";\n\t\t</script><script
|
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465
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+
src=\"http://jhsearch.library.jhu.edu/javascript/collections.js\" language=\"javascript\"
|
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466
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type=\"text/javascript\"></script><script type=\"text/javascript\">\n\t\t\tvar
|
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467
|
+
_gaq = _gaq || [];\n\t\t\t_gaq.push(['_setAccount', 'UA-7867593-11']);\n\t\t\t_gaq.push(['_trackPageview']);\n\n\t\t\t(function()
|
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468
|
+
{\n\t\t\tvar ga = document.createElement('script'); ga.type = 'text/javascript';
|
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469
|
+
ga.async = true;\n\t\t\tga.src = ('https:' == document.location.protocol ?
|
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470
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+
'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';\n\t\t\tvar
|
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471
|
+
s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga,
|
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472
|
+
s);\n\t\t\t})();\n\t\t</script>\n</head>\n<body>\n<div class=\"ada\"><a href=\"http://jhsearch.library.jhu.edu/?&base=databases&action=accessible&return=%2Fmetasearch%2Fhits%3Fgroup%3D2012-05-22-000197\">For
|
|
473
|
+
best results, click this link for accessible version</a></div>\n<div id=\"doc3\"
|
|
474
|
+
class=\"yui-t6\">\n<div id=\"hd\">\n<div id=\"my_header\" style=\"background-color:
|
|
475
|
+
#00689B; margin-left: -10px; margin-right: -10px;\">\n<div class=\"header_nav\"
|
|
476
|
+
style=\"float:right;\">\n<a href=\"/databases/alphabetical\">\n\t\t\t\tDatabase
|
|
477
|
+
List (A-Z)\n </a><a href=\"http://findit.library.jhu.edu\">Journal List
|
|
478
|
+
(A-Z)</a>\n</div>\n<a style=\"color:white\" href=\"http://jhsearch.library.jhu.edu\"><img
|
|
479
|
+
src=\"http://jhsearch.library.jhu.edu/localweb/images/jhsearch-banner.jpg\"
|
|
480
|
+
alt=\"JHSearch\"></a>\n</div>\n<div id=\"breadcrumb\"><div class=\"trail\">\n<a
|
|
481
|
+
href=\"http://jhsearch.library.jhu.edu?\">Home</a> > <a href=\"\">bento_search</a>
|
|
482
|
+
> Search Status</div></div>\n</div>\n<div id=\"bd\">\n<div id=\"yui-main\"><div
|
|
483
|
+
class=\"yui-b\"><div id=\"metasearch_hits\">\n<h1>bento_search</h1>\n<form
|
|
484
|
+
action=\"./\" method=\"get\">\n<input type=\"hidden\" name=\"lang\" value=\"\"><input
|
|
485
|
+
type=\"hidden\" name=\"base\" value=\"metasearch\"><input type=\"hidden\"
|
|
486
|
+
name=\"action\" value=\"search\"><input type=\"hidden\" name=\"context\" value=\"bento_search\"><input
|
|
487
|
+
type=\"hidden\" name=\"context_url\" value=\"\"><div class=\"raisedBox searchBox\">\n<div
|
|
488
|
+
class=\"searchLabel\"><label for=\"field\">Search</label></div>\n<div class=\"searchInputs\">\n<select
|
|
489
|
+
id=\"field\" class=\"field\" name=\"field\"><option value=\"WRD\">all fields</option>\n<option
|
|
490
|
+
value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
|
|
491
|
+
value=\"WSU\">subject</option></select> <label for=\"query\">for</label> <input
|
|
492
|
+
id=\"query\" class=\"query\" name=\"query\" type=\"text\" size=\"32\" value=\"skin
|
|
493
|
+
disease\"><label for=\"find_operator1\" class=\"find_operator1label ada\"
|
|
494
|
+
style=\"display:none;\">Boolean operator: </label> <select id=\"find_operator1\"
|
|
495
|
+
class=\"find_operator1\" name=\"find_operator1\" style=\"display:none;\"><option
|
|
496
|
+
value=\"AND\">And</option>\n<option value=\"OR\">Or</option>\n<option value=\"NOT\">Without</option></select><div
|
|
497
|
+
class=\"searchBox_advanced_newline\" style=\"display:none;\"></div>\n<label
|
|
498
|
+
for=\"field2\" class=\"ada field2label\" style=\"display:none;\">Search</label><span
|
|
499
|
+
class=\"searchBox_advanced_pair\" style=\"display:none;\"><select id=\"field2\"
|
|
500
|
+
class=\"field2\" name=\"field2\"><option value=\"WRD\">all fields</option>\n<option
|
|
501
|
+
value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
|
|
502
|
+
value=\"WSU\">subject</option>\n<option value=\"ISSN\">ISSN</option>\n<option
|
|
503
|
+
value=\"ISBN\">ISBN</option>\n<option value=\"WYR\">year</option></select>
|
|
504
|
+
<label for=\"query2\">for</label> <input id=\"query2\" class=\"query2\" name=\"query2\"
|
|
505
|
+
type=\"text\" size=\"32\" value=\"\"> </span><input class=\"submit_searchbox_\"
|
|
506
|
+
type=\"submit\" name=\"Submit\" value=\"GO\">\n</div>\n<div class=\"metasearch_input_toggle\"><a
|
|
507
|
+
class=\"searchBox_toggle\" href=\"/metasearch/hits?group=2012-05-22-000197&metasearch_input_mode=advanced\">More
|
|
508
|
+
Options</a></div>\n</div>\n<input type=\"hidden\" name=\"database\" value=\"JHU04066\"><input
|
|
509
|
+
type=\"hidden\" name=\"database\" value=\"JHU06614\">\n</form>\n<h2>Search
|
|
510
|
+
Status</h2>\n<div id=\"progress\"><img src=\"images/progress_small1.gif\"
|
|
511
|
+
alt=\"\"></div>\n<table>\n<thead><tr>\n<th>Database</th>\n<th>Status</th>\n<th>Hits</th>\n</tr></thead>\n<tr>\n<td>Academic
|
|
512
|
+
Search Complete</td>\n<td>STARTED</td>\n<td class=\"hitCount\">0</td>\n</tr>\n<tr>\n<td>OmniFile
|
|
513
|
+
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s);\n\t\t\t})();\n\t\t</script>\n</head>\n<body>\n<div class=\"ada\"><a href=\"http://jhsearch.library.jhu.edu/?&base=databases&action=accessible&return=%2Fmetasearch%2Fresults%3Fgroup%3D2012-05-22-000200%26resultSet%3D004191\">For
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best results, click this link for accessible version</a></div>\n<div id=\"doc3\"
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924
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927
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action=\"./\" method=\"get\">\n<input type=\"hidden\" name=\"lang\" value=\"\"><input
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name=\"action\" value=\"search\"><input type=\"hidden\" name=\"context\" value=\"bento_search\"><input
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class=\"searchLabel\"><label for=\"field\">Search</label></div>\n<div class=\"searchInputs\">\n<select
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id=\"field\" class=\"field\" name=\"field\"><option value=\"WRD\">all fields</option>\n<option
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value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
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value=\"WSU\">subject</option></select> <label for=\"query\">for</label> <input
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id=\"query\" class=\"query\" name=\"query\" type=\"text\" size=\"32\" value=\"skin
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938
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disease\"><label for=\"find_operator1\" class=\"find_operator1label ada\"
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style=\"display:none;\">Boolean operator: </label> <select id=\"find_operator1\"
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class=\"find_operator1\" name=\"find_operator1\" style=\"display:none;\"><option
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value=\"AND\">And</option>\n<option value=\"OR\">Or</option>\n<option value=\"NOT\">Without</option></select><div
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class=\"searchBox_advanced_newline\" style=\"display:none;\"></div>\n<label
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for=\"field2\" class=\"ada field2label\" style=\"display:none;\">Search</label><span
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class=\"field2\" name=\"field2\"><option value=\"WRD\">all fields</option>\n<option
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value=\"WTI\">title</option>\n<option value=\"WAU\">author</option>\n<option
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value=\"WSU\">subject</option>\n<option value=\"ISSN\">ISSN</option>\n<option
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value=\"ISBN\">ISBN</option>\n<option value=\"WYR\">year</option></select>
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<label for=\"query2\">for</label> <input id=\"query2\" class=\"query2\" name=\"query2\"
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type=\"text\" size=\"32\" value=\"\"> </span><input class=\"submit_searchbox_\"
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951
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type=\"submit\" name=\"Submit\" value=\"GO\">\n</div>\n<div class=\"metasearch_input_toggle\"><a
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952
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class=\"searchBox_toggle\" href=\"/metasearch/results?group=2012-05-22-000200&resultSet=004191&metasearch_input_mode=advanced\">More
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953
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Options</a></div>\n</div>\n<input type=\"hidden\" name=\"database\" value=\"JHU04066\"><input
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954
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type=\"hidden\" name=\"database\" value=\"JHU06614\">\n</form>\n<h2>Top Results</h2>\n<div
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id=\"sort\"><div class=\"yui-gd\">\n<div class=\"yui-u first\">\n\t\tResults
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<strong>1-10</strong> \n\t\tof <strong>60</strong>\n</div>\n<div class=\"yui-u\"><div
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id=\"sortOptions\">sort by: <strong>relevance</strong> | <a href=\"/metasearch/sort?group=2012-05-22-000200&sortKeys=year\">date</a>
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958
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| <a href=\"/metasearch/sort?group=2012-05-22-000200&sortKeys=title\">title</a>
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959
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| <a href=\"/metasearch/sort?group=2012-05-22-000200&sortKeys=author\">author</a>\n</div></div>\n</div></div>\n<ul
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960
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id=\"results\">\n<li class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=1\">Expression
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961
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of Hepatocyte Growth Factor in the Skin of Amyotrophic Lateral Sclerosis</a></div>\n<div
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962
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class=\"resultsInfo\">\n<div class=\"resultsType\">Article</div>\n<div class=\"resultsAbstract\">Nomura
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963
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M, Oketa Y, Yasui K, Ishikawa H, Ono S. Expression of hepatocyte growth factor
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964
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in the skin of amyotrophic lateral sclerosis. Acta Neurol Scand: 2012: 125:
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389-397. (c) 2011 John Wiley & Sons A/S. Objectives - Hepatocyte growth
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factor (HGF) is one of the most potent survival-promoting fact . . .\n\t\t\t\t\t\t</div>\n<span
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967
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+
class=\"resultsAuthor\"><strong>By: </strong>Nomura, M </span><span class=\"resultsYear\"><strong>Year:
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968
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</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
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969
|
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</strong>Acta Neurologica Scandinavica</span><div class=\"recordActions\">\n<a
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970
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+
href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004189&startRecord=000010&fulltext=1\"
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target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
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972
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width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
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973
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linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004189_000010\"
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974
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class=\"recordAction saveRecord\">\n<img id=\"folder_004189000010\" name=\"folder_004189000010\"
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width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
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src=\"images/folder.gif\"> <a id=\"link_004189:000010\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004189&startRecord=000010\"
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class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
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978
|
+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=2\">Sarcoma
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979
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Metastases to the Skin</a></div>\n<div class=\"resultsInfo\">\n<div class=\"resultsType\">Article</div>\n<div
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980
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+
class=\"resultsAbstract\">BACKGROUND: Sarcoma metastases to the skin are relatively
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981
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rare, because most involve the lung, liver, or deep soft tissues. The authors
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982
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+
of this report examined the distribution and clinical significance of cutaneous
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983
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+
and superficial subcutaneous sarcoma metastases. METHODS: Sixty-five patients
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984
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+
with h . . .\n\t\t\t\t\t\t</div>\n<span class=\"resultsAuthor\"><strong>By:
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985
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+
</strong>Wang, Wei-Lien </span><span class=\"resultsYear\"><strong>Year: </strong>2012</span><span
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986
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class=\"resultsPublishing\"><strong>Published in: </strong>Cancer (0008543X)</span><div
|
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987
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+
class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004189&startRecord=000021&fulltext=1\"
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988
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+
target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
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989
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+
width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
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990
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+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004189_000021\"
|
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991
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+
class=\"recordAction saveRecord\">\n<img id=\"folder_004189000021\" name=\"folder_004189000021\"
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992
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+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
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993
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src=\"images/folder.gif\"> <a id=\"link_004189:000021\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004189&startRecord=000021\"
|
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994
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+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
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995
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class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=3\">Skin
|
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996
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Disease; Shoes for Shows?</a></div>\n<div class=\"resultsInfo\">\n<div class=\"resultsType\">Article</div>\n<div
|
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997
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class=\"resultsAbstract\">The article provides an answer to a question regarding
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998
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+
pemphigus foliaceous disorder of a gelding 17-year-old TennesseeWalking Horse.</div>\n<span
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999
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+
class=\"resultsAuthor\"><strong>By: </strong>, </span><span class=\"resultsYear\"><strong>Year:
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1000
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+
</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
|
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1001
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+
</strong>Horse & Rider</span><div class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000009&fulltext=1\"
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1002
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+
target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
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1003
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width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
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1004
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+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004190_000009\"
|
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1005
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+
class=\"recordAction saveRecord\">\n<img id=\"folder_004190000009\" name=\"folder_004190000009\"
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1006
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+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
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1007
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+
src=\"images/folder.gif\"> <a id=\"link_004190:000009\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004190&startRecord=000009\"
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1008
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+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
|
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1009
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+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=4\">Mutations
|
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1010
|
+
in UVSSA Cause UV-sensitive Syndrome and Impair RNA Polymerase IIo Processing
|
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1011
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in Transcription-coupled Nucleotide-excision Repair</a></div>\n<div class=\"resultsInfo\">\n<div
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1012
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+
class=\"resultsType\">Article</div>\n<div class=\"resultsAbstract\">UV-sensitive
|
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1013
|
+
syndrome (UVSS) is a genodermatosis characterized by cutaneous photosensitivity
|
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1014
|
+
without skin carcinoma. Despite mild clinical features, cells from individuals
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1015
|
+
with UVSS, like Cockayne syndrome cells, are very UV sensitive and are deficient
|
|
1016
|
+
in transcription-coupled nucleotide-excision re . . .\n\t\t\t\t\t\t</div>\n<span
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1017
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+
class=\"resultsAuthor\"><strong>By: </strong>Nakazawa, Yuka </span><span class=\"resultsYear\"><strong>Year:
|
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1018
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+
</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
|
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1019
|
+
</strong>Nature Genetics</span><div class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000011&fulltext=1\"
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1020
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target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
|
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1021
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+
width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
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1022
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+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004190_000011\"
|
|
1023
|
+
class=\"recordAction saveRecord\">\n<img id=\"folder_004190000011\" name=\"folder_004190000011\"
|
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1024
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+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
|
1025
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+
src=\"images/folder.gif\"> <a id=\"link_004190:000011\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004190&startRecord=000011\"
|
|
1026
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+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
|
|
1027
|
+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=5\">Inhalation
|
|
1028
|
+
Versus Skin Exposure: Have We Got the Balance Right?</a></div>\n<div class=\"resultsInfo\">\n<div
|
|
1029
|
+
class=\"resultsType\">Article</div>\n<div class=\"resultsAbstract\">Covers
|
|
1030
|
+
the topics: Great Britain; World Health Organization; Protective clothing;
|
|
1031
|
+
Skin -- Diseases; Spirometry; Environmental exposure; Skin -- Diseases --
|
|
1032
|
+
Prevention; Industrial safety -- Great Britain</div>\n<span class=\"resultsAuthor\"><strong>By:
|
|
1033
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+
</strong>Packham, Chris Partner, EnviroDerm Services </span><span class=\"resultsYear\"><strong>Year:
|
|
1034
|
+
</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
|
|
1035
|
+
</strong>Occupational Health</span><div class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000014&fulltext=1\"
|
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1036
|
+
target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
|
|
1037
|
+
width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
|
1038
|
+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004190_000014\"
|
|
1039
|
+
class=\"recordAction saveRecord\">\n<img id=\"folder_004190000014\" name=\"folder_004190000014\"
|
|
1040
|
+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
|
1041
|
+
src=\"images/folder.gif\"> <a id=\"link_004190:000014\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004190&startRecord=000014\"
|
|
1042
|
+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
|
|
1043
|
+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=6\">Integrin
|
|
1044
|
+
α3 Mutations with Kidney, Lung, and Skin Disease</a></div>\n<div class=\"resultsInfo\">\n<div
|
|
1045
|
+
class=\"resultsType\">Article</div>\n<div class=\"resultsAbstract\">: Integrin
|
|
1046
|
+
α3 is a transmembrane integrin receptor subunit that mediates signals between
|
|
1047
|
+
the cells and their microenvironment. We identified three patients with homozygous
|
|
1048
|
+
mutations in the integrin α3 gene that were associated with disrupted basement-membrane
|
|
1049
|
+
structures and compromised barrier funct . . .\n\t\t\t\t\t\t</div>\n<span
|
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1050
|
+
class=\"resultsAuthor\"><strong>By: </strong>Has, Cristina </span><span class=\"resultsYear\"><strong>Year:
|
|
1051
|
+
</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
|
|
1052
|
+
</strong>New England Journal of Medicine</span><div class=\"recordActions\">\n<a
|
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1053
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+
href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000016&fulltext=1\"
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1054
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+
target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
|
|
1055
|
+
width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
|
1056
|
+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004190_000016\"
|
|
1057
|
+
class=\"recordAction saveRecord\">\n<img id=\"folder_004190000016\" name=\"folder_004190000016\"
|
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1058
|
+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
|
1059
|
+
src=\"images/folder.gif\"> <a id=\"link_004190:000016\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004190&startRecord=000016\"
|
|
1060
|
+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
|
|
1061
|
+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=7\">Skin
|
|
1062
|
+
Deep</a></div>\n<div class=\"resultsInfo\">\n<div class=\"resultsType\">Article</div>\n<div
|
|
1063
|
+
class=\"resultsAbstract\">The article describes the case of a 56-year-old
|
|
1064
|
+
woman diagnosed with cutaneous mycobacterial infection. The patient presented
|
|
1065
|
+
with symptoms of carpal tunnel syndrome for 6 months and was referred to a
|
|
1066
|
+
clinic with nodular lesions on her right forearm and hand that had appeared
|
|
1067
|
+
4 months before consult . . .\n\t\t\t\t\t\t</div>\n<span class=\"resultsAuthor\"><strong>By:
|
|
1068
|
+
</strong>Safdar, Nasia </span><span class=\"resultsYear\"><strong>Year: </strong>2012</span><span
|
|
1069
|
+
class=\"resultsPublishing\"><strong>Published in: </strong>New England Journal
|
|
1070
|
+
of Medicine</span><div class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000018&fulltext=1\"
|
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1071
|
+
target=\"_blank\" class=\"recordAction linkResolverLink\"><img src=\"http://jhsearch.library.jhu.edu/images/html.gif\"
|
|
1072
|
+
width=\"16\" height=\"16\" border=\"0\" alt=\"\" title=\"\" class=\"miniIcon
|
|
1073
|
+
linkResolverLink\"> Full-Text via Find It</a><div id=\"saveRecordOption_004190_000018\"
|
|
1074
|
+
class=\"recordAction saveRecord\">\n<img id=\"folder_004190000018\" name=\"folder_004190000018\"
|
|
1075
|
+
width=\"17\" height=\"15\" alt=\"\" border=\"0\" class=\"miniIcon saveRecordLink\"
|
|
1076
|
+
src=\"images/folder.gif\"> <a id=\"link_004190:000018\" href=\"/metasearch/save-delete?group=2012-05-22-000200&resultSet=004190&startRecord=000018\"
|
|
1077
|
+
class=\"\n\t\t\t\t\t\t\t\t\t\t saveRecord \">Save this record</a>\n</div>\n</div>\n</div>\n</li>\n<li
|
|
1078
|
+
class=\"result\">\n<div class=\"resultsTitle\"><a href=\"/metasearch/record?group=2012-05-22-000200&resultSet=004191&startRecord=8\">Skin
|
|
1079
|
+
Infection Generates Non-migratory Memory CD8+ TRM Cells Providing Global Skin
|
|
1080
|
+
Immunity</a></div>\n<div class=\"resultsInfo\">\n<div class=\"resultsType\">Article</div>\n<div
|
|
1081
|
+
class=\"resultsAbstract\">Protective T-cell memory has long been thought to
|
|
1082
|
+
reside in blood and lymph nodes, but recently the concept of immune memory
|
|
1083
|
+
in peripheral tissues mediated by resident memory T (TRM) cells has been proposed.
|
|
1084
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+
Here we show in mice that localized vaccinia virus (VACV) skin infection generates
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1088
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</strong>Nature</span><div class=\"recordActions\">\n<a href=\"/metasearch/sfx?group=2012-05-22-000200&resultSet=004190&startRecord=000027&fulltext=1\"
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Serum Baseline Tryptase Levels and Extensive Skin Involvement Are Predictors
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for the Severity of Mast Cell Activation Episodes in Children with Mastocytosis</a></div>\n<div
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Despite the good prognosis of pediatric mastocytosis, some patients suffer
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from severe mast cell ( MC) mediator-associated symptoms. The aim of this
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study was to identify predictors for severe MC mediator release symptoms in
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children with mastocytosis in the skin ( MIS). Methods Serum bas . . .\n\t\t\t\t\t\t</div>\n<span
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Mebutate Gel for Actinic Keratosis</a></div>\n<div class=\"resultsInfo\">\n<div
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Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma.
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can eradicate clinical and subclinical actinic keratoses. Topical field therapy
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</strong>2012</span><span class=\"resultsPublishing\"><strong>Published in:
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</strong>New England Journal of Medicine</span><div class=\"recordActions\">\n<a
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\t\t( 14 )\n\t\t\t</li>\n<li>\n<a href=\"/metasearch/facet?group=2012-05-22-000200&resultSet=004191&facet=1&node=9\">Treatment</a>\n\t\t
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1184
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Hopkins Libraries</a>. Powered by <a href=\"http://www.exlibris.co.il/category/MetaLibOverview\">Ex-Libris
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language=\"javascript\" type=\"text/javascript\"></script><script type=\"text/javascript\">\n\t\t\t\n\t\t\t//
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change numSessionSavedRecords to numSavedRecords if you prefer the folder
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icon to change\n\t\t\t// if there are any records at all in saved records.
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1258
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|
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1259
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1260
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1261
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1267
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1268
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List (A-Z)\n </a><a href=\"http://findit.library.jhu.edu\">Journal List
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1269
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icon to change\n\t\t\t// if there are any records at all in saved records.
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1389
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|
1396
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best results, click this link for accessible version</a></div>\n<div id=\"doc3\"
|
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1397
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#00689B; margin-left: -10px; margin-right: -10px;\">\n<div class=\"header_nav\"
|
|
1399
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+
style=\"float:right;\">\n<a href=\"/databases/alphabetical\">\n\t\t\t\tDatabase
|
|
1400
|
+
List (A-Z)\n </a><a href=\"http://findit.library.jhu.edu\">Journal List
|
|
1401
|
+
(A-Z)</a>\n</div>\n<a style=\"color:white\" href=\"http://jhsearch.library.jhu.edu\"><img
|
|
1402
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|
|
1403
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|
|
1404
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href=\"http://jhsearch.library.jhu.edu?\">Home</a> > <a href=\"\">bento_search</a>
|
|
1405
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> Search Status</div></div>\n</div>\n<div id=\"bd\">\n<div id=\"yui-main\"><div
|
|
1406
|
+
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|
|
1407
|
+
action=\"./\" method=\"get\">\n<input type=\"hidden\" name=\"lang\" value=\"\"><input
|
|
1408
|
+
type=\"hidden\" name=\"base\" value=\"metasearch\"><input type=\"hidden\"
|
|
1409
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+
name=\"action\" value=\"search\"><input type=\"hidden\" name=\"context\" value=\"bento_search\"><input
|
|
1410
|
+
type=\"hidden\" name=\"context_url\" value=\"\"><div class=\"raisedBox searchBox\">\n<div
|
|
1411
|
+
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|
|
1412
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|
|
1413
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|
|
1414
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|
|
1415
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|
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1416
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disease\"><label for=\"find_operator1\" class=\"find_operator1label ada\"
|
|
1417
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|
|
1418
|
+
class=\"find_operator1\" name=\"find_operator1\" style=\"display:none;\"><option
|
|
1419
|
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|
|
1420
|
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|
|
1421
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|
|
1422
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|
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1423
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|
|
1424
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|
|
1425
|
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value=\"WSU\">subject</option>\n<option value=\"ISSN\">ISSN</option>\n<option
|
|
1426
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value=\"ISBN\">ISBN</option>\n<option value=\"WYR\">year</option></select>
|
|
1427
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<label for=\"query2\">for</label> <input id=\"query2\" class=\"query2\" name=\"query2\"
|
|
1428
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|
|
1429
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type=\"submit\" name=\"Submit\" value=\"GO\">\n</div>\n<div class=\"metasearch_input_toggle\"><a
|
|
1430
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|
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1431
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|
|
1432
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|
|
1433
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Status</h2>\n<div id=\"progress\"><img src=\"images/progress_small1.gif\"
|
|
1434
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+
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|
|
1435
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|
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1436
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Full Text Mega</full_name>\n<base_001>JHU06614</base_001>\n<set_number>004875</set_number>\n<find_status>DONE</find_status>\n<no_of_documents>3,494</no_of_documents>\n<url>/metasearch/results?group=2012-05-22-000249&amp;resultSet=004875</url></base_info>\n<group_number>000249</group_number>\n<base_info>\n<base>MERGESET</base>\n<full_name>Combined
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new_session=\"N\">GV56ULH8AVC3X566H6LBP2244YRH6P9B2BLJG43MLQPUR5Q54E</session_id>\n</find_group_info_response><progress>10</progress><records><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=1</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004874&startRecord=000010</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004874&startRecord=000010</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+Academic+Search+Complete%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00016314&rft.date=2012&rft.jtitle=Acta+Neurologica+Scandinavica&rft.volume=125&rft.issue=6&rft.spage=389&rft.epage=397&rft.atitle=Expression+of+hepatocyte+growth+factor+in+the+skin+of+amyotrophic+lateral+sclerosis+&rft.aulast=Nomura&rft.aufirst=M</openurl_kev_co><xerxes_record><title_normalized>Expression
|
|
1914
|
+
of Hepatocyte Growth Factor in the Skin of Amyotrophic Lateral Sclerosis</title_normalized><journal_title>Acta
|
|
1915
|
+
Neurologica Scandinavica</journal_title><primary_author>Nomura, M </primary_author><authors><author
|
|
1916
|
+
type=\"personal\" rank=\"1\"><aulast>Nomura</aulast><aufirst>M</aufirst><display>Nomura,
|
|
1917
|
+
M. 1</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Oketa</aulast><aufirst>Y</aufirst><display>Oketa,
|
|
1918
|
+
Y. 1</display></author><author type=\"personal\" additional=\"true\" rank=\"3\"><aulast>Yasui</aulast><aufirst>K</aufirst><display>Yasui,
|
|
1919
|
+
K. 1</display></author><author type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Ishikawa</aulast><aufirst>H</aufirst><display>Ishikawa,
|
|
1920
|
+
H. 1</display></author><author type=\"personal\" additional=\"true\" rank=\"5\"><aulast>Ono</aulast><aufirst>S</aufirst><display>Ono,
|
|
1921
|
+
S. 1</display></author></authors><standard_numbers><issn>00016314</issn></standard_numbers><links><link
|
|
1922
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&an=74436494&db=a9h&scope=site</url></link></links><subjects><subject
|
|
1923
|
+
value=\"amyotrophic lateral sclerosis\">amyotrophic lateral sclerosis</subject><subject
|
|
1924
|
+
value=\"epidermis\">epidermis</subject><subject value=\"hepatocyte growth
|
|
1925
|
+
factor\">hepatocyte growth factor</subject><subject value=\"immunohistochemistry\">immunohistochemistry</subject><subject
|
|
1926
|
+
value=\"skin\">skin</subject><subject value=\"HEPATOCYTE growth factor\">HEPATOCYTE
|
|
1927
|
+
growth factor</subject><subject value=\"AMYOTROPHIC lateral sclerosis\">AMYOTROPHIC
|
|
1928
|
+
lateral sclerosis</subject><subject value=\"MOTOR neurons\">MOTOR neurons</subject><subject
|
|
1929
|
+
value=\"MUSCLE weakness\">MUSCLE weakness</subject><subject value=\"SPINAL
|
|
1930
|
+
muscular atrophy\">SPINAL muscular atrophy</subject><subject value=\"SKIN
|
|
1931
|
+
-- Physiology\">SKIN -- Physiology</subject></subjects><metalib_id>JHU04066</metalib_id><result_set>004874</result_set><record_number>000010</record_number><source>EBSCO_A9H</source><database_name>Academic
|
|
1932
|
+
Search Complete</database_name><record_id>74436494</record_id><format>Article</format><control_number>74436494</control_number><title>Expression
|
|
1933
|
+
of hepatocyte growth factor in the skin of amyotrophic lateral sclerosis</title><year>2012</year><journal>Acta
|
|
1934
|
+
Neurologica Scandinavica Jun2012, Vol. 125 Issue 6, p389-397 9p 00016314</journal><volume>125</volume><issue>6</issue><start_page>389</start_page><end_page>397</end_page><abstract>Nomura
|
|
1935
|
+
M, Oketa Y, Yasui K, Ishikawa H, Ono S. Expression of hepatocyte growth factor
|
|
1936
|
+
in the skin of amyotrophic lateral sclerosis. Acta Neurol Scand: 2012: 125:
|
|
1937
|
+
389-397. (c) 2011 John Wiley & Sons A/S. Objectives - Hepatocyte growth
|
|
1938
|
+
factor (HGF) is one of the most potent survival-promoting factors for motor
|
|
1939
|
+
neurons. Overexpression of neuronal HGF has been shown to result in the attenuation
|
|
1940
|
+
of neuronal cell death and progression of disease in a familial amyotrophic
|
|
1941
|
+
lateral sclerosis (ALS) transgenic mouse model. HGF might be beneficial for
|
|
1942
|
+
motor neuron survival and is a good candidate agent for the treatment of ALS.
|
|
1943
|
+
So far, studies of the skin of ALS have shown unique pathological and biochemical
|
|
1944
|
+
abnormalities. However, there has been no study of HGF in ALS skin. Materials
|
|
1945
|
+
and Methods - We made a quantitative immunohistochemical study of the expression
|
|
1946
|
+
of HGF in the skin from 19 patients with sporadic ALS and 16 controls. Results
|
|
1947
|
+
- Hepatocyte growth factor immunoreactivity was ^positive in the epidermis,
|
|
1948
|
+
some dermal blood vessels, and glands in patients with ALS. These findings
|
|
1949
|
+
became more conspicuous as ALS progressed. The optical density for HGF immunoreactivity
|
|
1950
|
+
of the nucleus and the cytoplasm in the epidermis in ALS was significantly
|
|
1951
|
+
higher ( P < 0.001 and P < 0.001) than in controls. There was a significant
|
|
1952
|
+
positive relation ( r = 0.53, P < 0.02 and r = 0.73, P < 0.001) between
|
|
1953
|
+
HGF immunoreactivity and duration of illness in the nucleus and the cytoplasm
|
|
1954
|
+
in the epidermis in patients with ALS. Conclusions - These findings suggest
|
|
1955
|
+
that changes in HGF in ALS skin are related to the disease process and that
|
|
1956
|
+
metabolic alterations of HGF may take place in the skin of patients with ALS.
|
|
1957
|
+
[ABSTRACT FROM AUTHOR]o study of HGF in ALS skin. Materials and Methods -
|
|
1958
|
+
\ We made a quantitative immunohistochemical study of the expression of HGF
|
|
1959
|
+
in the skin from 19 patients with sporadic ALS and 16 controls. Results -
|
|
1960
|
+
\ Hepatocyte growth factor immunoreactivity was</abstract><summary>Nomura
|
|
1961
|
+
M, Oketa Y, Yasui K, Ishikawa H, Ono S. Expression of hepatocyte growth factor
|
|
1962
|
+
in the skin of amyotrophic lateral sclerosis. Acta Neurol Scand: 2012: 125:
|
|
1963
|
+
389-397. (c) 2011 John Wiley & Sons A/S. Objectives - Hepatocyte growth
|
|
1964
|
+
factor (HGF) is one of the most potent survival-promoting factors for motor
|
|
1965
|
+
neurons. Overexpression of neuronal HGF has been shown to result in the attenuation
|
|
1966
|
+
of neuronal cell death and progression of disease in a familial amyotrophic
|
|
1967
|
+
lateral sclerosis (ALS) transgenic mouse model. HGF might be beneficial for
|
|
1968
|
+
motor neuron survival and is a good candidate agent for the treatment of ALS.
|
|
1969
|
+
So far, studies of the skin of ALS have shown unique pathological and biochemical
|
|
1970
|
+
abnormalities. However, there has been no study of HGF in ALS skin. Materials
|
|
1971
|
+
and Methods - We made a quantitative immunohistochemical study of the expression
|
|
1972
|
+
of HGF in the skin from 19 patients with sporadic ALS and 16 controls. Results
|
|
1973
|
+
- Hepatocyte growth factor immunoreactivity was ^positive in the epidermis,
|
|
1974
|
+
some dermal blood vessels, and glands in patients with ALS. These findings
|
|
1975
|
+
became more conspicuous as ALS progressed. The optical density for HGF immunoreactivity
|
|
1976
|
+
of the nucleus and the cytoplasm in the epidermis in ALS was significantly
|
|
1977
|
+
higher ( P < 0.001 and P < 0.001) than in controls. There was a significant
|
|
1978
|
+
positive relation ( r = 0.53, P < 0.02 and r = 0.73, P < 0.001) between
|
|
1979
|
+
HGF immunoreactivity and duration of illness in the nucleus and the cytoplasm
|
|
1980
|
+
in the epidermis in patients with ALS. Conclusions - These findings suggest
|
|
1981
|
+
that changes in HGF in ALS skin are related to the disease process and that
|
|
1982
|
+
metabolic alterations of HGF may take place in the skin of patients with ALS.
|
|
1983
|
+
[ABSTRACT FROM AUTHOR]o study of HGF in ALS skin. Materials and Methods -
|
|
1984
|
+
\ We made a quantitative immunohistochemical study of the expression of HGF
|
|
1985
|
+
in the skin from 19 patients with sporadic ALS and 16 controls. Results -
|
|
1986
|
+
\ Hepatocyte growth factor immunoreactivity was</summary><summary_type>abstract</summary_type><notes><note>\nUncontrolled
|
|
1987
|
+
terms\nEnglish\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=2</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004874&startRecord=000021</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004874&startRecord=000021</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+Academic+Search+Complete%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=0008543X&rft.date=2012&rft.jtitle=Cancer+%280008543X%29&rft.volume=118&rft.issue=11&rft.spage=2900&rft.epage=2904&rft.atitle=Sarcoma+metastases+to+the+skin+&rft.aulast=Wang&rft.aufirst=Wei-Lien</openurl_kev_co><xerxes_record><title_normalized>Sarcoma
|
|
1988
|
+
Metastases to the Skin</title_normalized><journal_title>Cancer (0008543X)</journal_title><primary_author>Wang,
|
|
1989
|
+
Wei-Lien </primary_author><authors><author type=\"personal\" rank=\"1\"><aulast>Wang</aulast><aufirst>Wei-Lien</aufirst><display>Wang,
|
|
1990
|
+
Wei-Lien 1</display></author><author type=\"personal\" additional=\"true\"
|
|
1991
|
+
rank=\"2\"><aulast>Bones-Valentin</aulast><aufirst>Ross</aufirst><auinit>A</auinit><display>Bones-Valentin,
|
|
1992
|
+
Ross A. 2</display></author><author type=\"personal\" additional=\"true\"
|
|
1993
|
+
rank=\"3\"><aulast>Prieto</aulast><aufirst>Victor</aufirst><auinit>G</auinit><display>Prieto,
|
|
1994
|
+
Victor G. 1,3</display></author><author type=\"personal\" additional=\"true\"
|
|
1995
|
+
rank=\"4\"><aulast>Pollock</aulast><aufirst>Raphael</aufirst><auinit>E</auinit><display>Pollock,
|
|
1996
|
+
Raphael E. 2,4</display></author><author type=\"personal\" additional=\"true\"
|
|
1997
|
+
rank=\"5\"><aulast>Lev</aulast><aufirst>Dina</aufirst><auinit>C</auinit><display>Lev,
|
|
1998
|
+
Dina C. 2,5</display></author><author type=\"personal\" additional=\"true\"
|
|
1999
|
+
rank=\"6\"><aulast>Lazar</aulast><aufirst>Alexander</aufirst><auinit>J</auinit><display>Lazar,
|
|
2000
|
+
Alexander J. 1,2</display></author></authors><standard_numbers><issn>0008543X</issn></standard_numbers><links><link
|
|
2001
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&an=75344446&db=a9h&scope=site</url></link></links><subjects><subject
|
|
2002
|
+
value=\"cutaneous\">cutaneous</subject><subject value=\"leiomyosarcoma\">leiomyosarcoma</subject><subject
|
|
2003
|
+
value=\"metastatic\">metastatic</subject><subject value=\"prognosis\">prognosis</subject><subject
|
|
2004
|
+
value=\"sarcoma\">sarcoma</subject><subject value=\"skin\">skin</subject></subjects><metalib_id>JHU04066</metalib_id><result_set>004874</result_set><record_number>000021</record_number><source>EBSCO_A9H</source><database_name>Academic
|
|
2005
|
+
Search Complete</database_name><record_id>75344446</record_id><format>Article</format><control_number>75344446</control_number><title>Sarcoma
|
|
2006
|
+
metastases to the skin</title><year>2012</year><journal>Cancer (0008543X)
|
|
2007
|
+
Jun2012, Vol. 118 Issue 11, p2900-2904 5p 0008543X</journal><volume>118</volume><issue>11</issue><start_page>2900</start_page><end_page>2904</end_page><abstract>BACKGROUND:
|
|
2008
|
+
Sarcoma metastases to the skin are relatively rare, because most involve the
|
|
2009
|
+
lung, liver, or deep soft tissues. The authors of this report examined the
|
|
2010
|
+
distribution and clinical significance of cutaneous and superficial subcutaneous
|
|
2011
|
+
sarcoma metastases. METHODS: Sixty-five patients with histologically confirmed
|
|
2012
|
+
dermal and superficial subcutaneous sarcoma metastases were identified in
|
|
2013
|
+
pathology files from more than 25,000 patients with sarcoma who were evaluated
|
|
2014
|
+
at The University of Texas M. D. Anderson Cancer Center from 1989 to 2009.
|
|
2015
|
+
Pathology slides and clinical and radiological information were evaluated.
|
|
2016
|
+
RESULTS: Cutaneous metastases were documented histologically in</abstract><summary>BACKGROUND:
|
|
2017
|
+
Sarcoma metastases to the skin are relatively rare, because most involve the
|
|
2018
|
+
lung, liver, or deep soft tissues. The authors of this report examined the
|
|
2019
|
+
distribution and clinical significance of cutaneous and superficial subcutaneous
|
|
2020
|
+
sarcoma metastases. METHODS: Sixty-five patients with histologically confirmed
|
|
2021
|
+
dermal and superficial subcutaneous sarcoma metastases were identified in
|
|
2022
|
+
pathology files from more than 25,000 patients with sarcoma who were evaluated
|
|
2023
|
+
at The University of Texas M. D. Anderson Cancer Center from 1989 to 2009.
|
|
2024
|
+
Pathology slides and clinical and radiological information were evaluated.
|
|
2025
|
+
RESULTS: Cutaneous metastases were documented histologically in</summary><summary_type>abstract</summary_type><notes><note>\nUncontrolled
|
|
2026
|
+
terms\nEnglish\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=3</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000009</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000009</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00185159&rft.date=2012&rft.tpages=2+pages&rft.jtitle=Horse+%26+Rider&rft.volume=51&rft.issue=5&rft.spage=16&rft.epage=17&rft.atitle=Skin+Disease%3B+Shoes+for+Shows%3F+</openurl_kev_co><xerxes_record><title_normalized>Skin
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|
2027
|
+
Disease; Shoes for Shows?</title_normalized><journal_title>Horse & Rider</journal_title><primary_author>,
|
|
2028
|
+
\ </primary_author><authors><author type=\"personal\" rank=\"1\"/></authors><standard_numbers><issn>00185159</issn></standard_numbers><links><link
|
|
2029
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=74229342&site=ehost-live</url></link></links><subjects><subject
|
|
2030
|
+
value=\"Horses -- Diseases\">Horses -- Diseases</subject><subject value=\"Geldings\">Geldings</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000009</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2031
|
+
Full Text Mega</database_name><format>Article</format><title>Skin Disease;
|
|
2032
|
+
Shoes for Shows?</title><year>2012</year><extent>2 pages</extent><journal>Horse
|
|
2033
|
+
& Rider vol.51 no.5 pp.16-17</journal><volume>51</volume><issue>5</issue><start_page>16</start_page><end_page>17</end_page><description>2
|
|
2034
|
+
pages Publication type:Periodical</description><abstract>The article provides
|
|
2035
|
+
an answer to a question regarding pemphigus foliaceous disorder of a gelding
|
|
2036
|
+
17-year-old TennesseeWalking Horse.</abstract><summary>The article provides
|
|
2037
|
+
an answer to a question regarding pemphigus foliaceous disorder of a gelding
|
|
2038
|
+
17-year-old TennesseeWalking Horse.</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=4</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000011</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000011</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=10614036&rft.date=2012&rft.tpages=7+pages&rft.jtitle=Nature+Genetics&rft.volume=44&rft.issue=5&rft.spage=586&rft.epage=592&rft.atitle=Mutations+in+UVSSA+cause+UV-sensitive+syndrome+and+impair+RNA+polymerase+IIo+processing+in+transcription-coupled+nucleotide-excision+repair+&rft.aulast=Nakazawa&rft.aufirst=Yuka</openurl_kev_co><xerxes_record><title_normalized>Mutations
|
|
2039
|
+
in UVSSA Cause UV-sensitive Syndrome and Impair RNA Polymerase IIo Processing
|
|
2040
|
+
in Transcription-coupled Nucleotide-excision Repair</title_normalized><journal_title>Nature
|
|
2041
|
+
Genetics</journal_title><primary_author>Nakazawa, Yuka </primary_author><authors><author
|
|
2042
|
+
type=\"personal\" rank=\"1\"><aulast>Nakazawa</aulast><aufirst>Yuka</aufirst><display>Nakazawa,
|
|
2043
|
+
Yuka</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Sasaki</aulast><aufirst>Kensaku</aufirst><display>Sasaki,
|
|
2044
|
+
Kensaku</display></author><author type=\"personal\" additional=\"true\" rank=\"3\"><aulast>Mitsutake</aulast><aufirst>Norisato</aufirst><display>Mitsutake,
|
|
2045
|
+
Norisato</display></author><author type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Matsuse</aulast><aufirst>Michiko</aufirst><display>Matsuse,
|
|
2046
|
+
Michiko</display></author><author type=\"personal\" additional=\"true\" rank=\"5\"><aulast>Shimada</aulast><aufirst>Mayuko</aufirst><display>Shimada,
|
|
2047
|
+
Mayuko</display></author><author type=\"personal\" additional=\"true\" rank=\"6\"><aulast>Nardo</aulast><aufirst>Tiziana</aufirst><display>Nardo,
|
|
2048
|
+
Tiziana</display></author><author type=\"personal\" additional=\"true\" rank=\"7\"><aulast>Takahashi</aulast><aufirst>Yoshito</aufirst><display>Takahashi,
|
|
2049
|
+
Yoshito</display></author><author type=\"personal\" additional=\"true\" rank=\"8\"><aulast>Ohyama</aulast><aufirst>Kaname</aufirst><display>Ohyama,
|
|
2050
|
+
Kaname</display></author><author type=\"personal\" additional=\"true\" rank=\"9\"><aulast>Ito</aulast><aufirst>Kosei</aufirst><display>Ito,
|
|
2051
|
+
Kosei</display></author><author type=\"personal\" additional=\"true\" rank=\"10\"><aulast>Mishima</aulast><aufirst>Hiroyuki</aufirst><display>Mishima,
|
|
2052
|
+
Hiroyuki</display></author><author type=\"personal\" additional=\"true\" rank=\"11\"><aulast>Nomura</aulast><aufirst>Masayo</aufirst><display>Nomura,
|
|
2053
|
+
Masayo</display></author><author type=\"personal\" additional=\"true\" rank=\"12\"><aulast>Kinoshita</aulast><aufirst>Akira</aufirst><display>Kinoshita,
|
|
2054
|
+
Akira</display></author><author type=\"personal\" additional=\"true\" rank=\"13\"><aulast>Ono</aulast><aufirst>Shinji</aufirst><display>Ono,
|
|
2055
|
+
Shinji</display></author><author type=\"personal\" additional=\"true\" rank=\"14\"><aulast>Takenaka</aulast><aufirst>Katsuya</aufirst><display>Takenaka,
|
|
2056
|
+
Katsuya</display></author><author type=\"personal\" additional=\"true\" rank=\"15\"><aulast>Masuyama</aulast><aufirst>Ritsuko</aufirst><display>Masuyama,
|
|
2057
|
+
Ritsuko</display></author><author type=\"personal\" additional=\"true\" rank=\"16\"><aulast>Kudo</aulast><aufirst>Takashi</aufirst><display>Kudo,
|
|
2058
|
+
Takashi</display></author><author type=\"personal\" additional=\"true\" rank=\"17\"><aulast>Slor</aulast><aufirst>Hanoch</aufirst><display>Slor,
|
|
2059
|
+
Hanoch</display></author><author type=\"personal\" additional=\"true\" rank=\"18\"><aulast>Utani</aulast><aufirst>Atsushi</aufirst><display>Utani,
|
|
2060
|
+
Atsushi</display></author><author type=\"personal\" additional=\"true\" rank=\"19\"><aulast>Tateishi</aulast><aufirst>Satoshi</aufirst><display>Tateishi,
|
|
2061
|
+
Satoshi</display></author><author type=\"personal\" additional=\"true\" rank=\"20\"><aulast>Yamashita</aulast><aufirst>Shunichi
|
|
2062
|
+
1] Nagasaki University Research Centre for Genomic Instability and Carcinogenesis
|
|
2063
|
+
(NRGIC), Nagasaki, Japan. [2] Department of Molecular Medicine, Atomic Bomb
|
|
2064
|
+
Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2065
|
+
Nagasaki, Japan. [3] Department of Radiation Medical Sciences, Atomic Bomb
|
|
2066
|
+
Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2067
|
+
Nagasaki, Japan. [4] 1] Department of Human Genetics, Atomic Bomb Disease
|
|
2068
|
+
Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki,
|
|
2069
|
+
Japan. [2] 1] Nagasaki University Research Centre for Genomic Instability
|
|
2070
|
+
and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department of Radiation Medical
|
|
2071
|
+
Sciences, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences,
|
|
2072
|
+
Nagasaki University, Nagasaki, Japan. [3] 1] Nagasaki University Research
|
|
2073
|
+
Centre for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki, Japan.
|
|
2074
|
+
[2] Department of Radiation Medical Sciences, Atomic Bomb Disease Institute,
|
|
2075
|
+
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
|
|
2076
|
+
1] Nagasaki University Research Centre for Genomic Instability and Carcinogenesis
|
|
2077
|
+
(NRGIC), Nagasaki, Japan. [2] Department of Molecular Medicine, Atomic Bomb
|
|
2078
|
+
Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2079
|
+
Nagasaki, Japan</aufirst><display>Yamashita, Shunichi 1] Nagasaki University
|
|
2080
|
+
Research Centre for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki,
|
|
2081
|
+
Japan. [2] Department of Molecular Medicine, Atomic Bomb Disease Institute,
|
|
2082
|
+
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
|
|
2083
|
+
[3] Department of Radiation Medical Sciences, Atomic Bomb Disease Institute,
|
|
2084
|
+
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
|
|
2085
|
+
[4] 1] Department of Human Genetics, Atomic Bomb Disease Institute, Graduate
|
|
2086
|
+
School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. [2] 1]
|
|
2087
|
+
Nagasaki University Research Centre for Genomic Instability and Carcinogenesis
|
|
2088
|
+
(NRGIC), Nagasaki, Japan. [2] Department of Radiation Medical Sciences, Atomic
|
|
2089
|
+
Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2090
|
+
Nagasaki, Japan. [3] 1] Nagasaki University Research Centre for Genomic Instability
|
|
2091
|
+
and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department of Radiation Medical
|
|
2092
|
+
Sciences, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences,
|
|
2093
|
+
Nagasaki University, Nagasaki, Japan. 1] Nagasaki University Research Centre
|
|
2094
|
+
for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department
|
|
2095
|
+
of Molecular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical
|
|
2096
|
+
Sciences, Nagasaki University, Nagasaki, Japan</display></author><author type=\"personal\"
|
|
2097
|
+
additional=\"true\" rank=\"21\"><aulast>[3] Department of Radiation Medical
|
|
2098
|
+
Sciences</aulast><aufirst>Atomic Bomb Disease Institute, Graduate School of
|
|
2099
|
+
Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Istituto di Genetica
|
|
2100
|
+
Molecolare, Consiglio Nazionale delle Ricerche, Pavia, Italy. Innovative Beauty
|
|
2101
|
+
Science Laboratory, Kanebo Cosmetics Inc., Odawara, Japan. 1] Nagasaki University
|
|
2102
|
+
Research Centre for Genomic Instability and Carcinogenesis (NRGIC), Nagasaki,
|
|
2103
|
+
Japan. [2] Department of Environmental and Pharmaceutical Sciences, Graduate
|
|
2104
|
+
School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. 1] Nagasaki
|
|
2105
|
+
University Research Centre for Genomic Instability and Carcinogenesis (NRGIC),
|
|
2106
|
+
Nagasaki, Japan. [2] Department of Cell Biology, Graduate School of Biomedical
|
|
2107
|
+
Sciences, Nagasaki University, Nagasaki, Japan. Department of Human Genetics,
|
|
2108
|
+
Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki
|
|
2109
|
+
University, Nagasaki, Japan. 1] Nagasaki University Research Centre for Genomic
|
|
2110
|
+
Instability and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department of
|
|
2111
|
+
Human Genetics, Atomic Bomb Disease Institute, Graduate School of Biomedical
|
|
2112
|
+
Sciences, Nagasaki University, Nagasaki, Japan. Department of Molecular Genetics,
|
|
2113
|
+
Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
|
|
2114
|
+
Department of Cell Biology, Graduate School of Biomedical Sciences, Nagasaki
|
|
2115
|
+
Univer</aufirst><display>[3] Department of Radiation Medical Sciences, Atomic
|
|
2116
|
+
Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2117
|
+
Nagasaki, Japan. Istituto di Genetica Molecolare, Consiglio Nazionale delle
|
|
2118
|
+
Ricerche, Pavia, Italy. Innovative Beauty Science Laboratory, Kanebo Cosmetics
|
|
2119
|
+
Inc., Odawara, Japan. 1] Nagasaki University Research Centre for Genomic Instability
|
|
2120
|
+
and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department of Environmental
|
|
2121
|
+
and Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki
|
|
2122
|
+
University, Nagasaki, Japan. 1] Nagasaki University Research Centre for Genomic
|
|
2123
|
+
Instability and Carcinogenesis (NRGIC), Nagasaki, Japan. [2] Department of
|
|
2124
|
+
Cell Biology, Graduate School of Biomedical Sciences, Nagasaki University,
|
|
2125
|
+
Nagasaki, Japan. Department of Human Genetics, Atomic Bomb Disease Institute,
|
|
2126
|
+
Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
|
|
2127
|
+
1] Nagasaki University Research Centre for Genomic Instability and Carcinogenesis
|
|
2128
|
+
(NRGIC), Nagasaki, Japan. [2] Department of Human Genetics, Atomic Bomb Disease
|
|
2129
|
+
Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki,
|
|
2130
|
+
Japan. Department of Molecular Genetics, Medical Research Institute, Tokyo
|
|
2131
|
+
Medical and Dental University, Tokyo, Japan. Department of Cell Biology, Graduate
|
|
2132
|
+
School of Biomedical Sciences, Nagasaki Univer</display></author><author type=\"personal\"
|
|
2133
|
+
additional=\"true\" rank=\"22\"><aulast>sity</aulast><aufirst>Nagasaki, Japan.
|
|
2134
|
+
Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Graduate
|
|
2135
|
+
School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Human
|
|
2136
|
+
Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv
|
|
2137
|
+
University, Tel Aviv, Israel. Department of Dermatology, Graduate School of
|
|
2138
|
+
Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Institute of Molecular
|
|
2139
|
+
Embryology and Genetics, Kumamoto University, Kumamoto, Japan. 1] Department
|
|
2140
|
+
of Radiation Medical Sciences, Atomic Bomb Disease Institute, Graduate School
|
|
2141
|
+
of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. [2] Fukushima
|
|
2142
|
+
Medical University, Fukushima, Japan</aufirst><display>sity, Nagasaki, Japan.
|
|
2143
|
+
Department of Radioisotope Medicine, Atomic Bomb Disease Institute, Graduate
|
|
2144
|
+
School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Human
|
|
2145
|
+
Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv
|
|
2146
|
+
University, Tel Aviv, Israel. Department of Dermatology, Graduate School of
|
|
2147
|
+
Biomedical Sciences, Nagasaki University, Nagasaki, Japan. Institute of Molecular
|
|
2148
|
+
Embryology and Genetics, Kumamoto University, Kumamoto, Japan. 1] Department
|
|
2149
|
+
of Radiation Medical Sciences, Atomic Bomb Disease Institute, Graduate School
|
|
2150
|
+
of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. [2] Fukushima
|
|
2151
|
+
Medical University, Fukushima, Japan</display></author></authors><standard_numbers><issn>10614036</issn></standard_numbers><links><link
|
|
2152
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=74604523&site=ehost-live</url></link></links><subjects><subject
|
|
2153
|
+
value=\"Nucleotides -- Separation\">Nucleotides -- Separation</subject><subject
|
|
2154
|
+
value=\"RNA polymerases\">RNA polymerases</subject><subject value=\"Precancerous
|
|
2155
|
+
conditions\">Precancerous conditions</subject><subject value=\"Radiation injuries\">Radiation
|
|
2156
|
+
injuries</subject><subject value=\"Skin -- Effect of radiation on\">Skin --
|
|
2157
|
+
Effect of radiation on</subject><subject value=\"Skin -- Diseases -- Genetic
|
|
2158
|
+
aspects\">Skin -- Diseases -- Genetic aspects</subject><subject value=\"Skin
|
|
2159
|
+
-- Cancer -- Risk factors\">Skin -- Cancer -- Risk factors</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000011</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2160
|
+
Full Text Mega</database_name><format>Article</format><title>Mutations in
|
|
2161
|
+
UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing
|
|
2162
|
+
in transcription-coupled nucleotide-excision repair</title><year>2012</year><extent>7
|
|
2163
|
+
pages</extent><journal>Nature Genetics vol.44 no.5 pp.586-592</journal><volume>44</volume><issue>5</issue><start_page>586</start_page><end_page>592</end_page><description>7
|
|
2164
|
+
pages Publication type:Academic Journal</description><abstract>UV-sensitive
|
|
2165
|
+
syndrome (UVSS) is a genodermatosis characterized by cutaneous photosensitivity
|
|
2166
|
+
without skin carcinoma. Despite mild clinical features, cells from individuals
|
|
2167
|
+
with UVSS, like Cockayne syndrome cells, are very UV sensitive and are deficient
|
|
2168
|
+
in transcription-coupled nucleotide-excision repair (TC-NER), which removes
|
|
2169
|
+
DNA damage in actively transcribed genes. Three of the seven known UVSS cases
|
|
2170
|
+
carry mutations in the Cockayne syndrome genes ERCC8 or ERCC6 (also known
|
|
2171
|
+
as CSA and CSB, respectively). The remaining four individuals with UVSS, one
|
|
2172
|
+
of whom is described for the first time here, formed a separate UVSS-A complementation
|
|
2173
|
+
group; however, the responsible gene was unknown. Using exome sequencing,
|
|
2174
|
+
we determine that mutations in the UVSSA gene (formerly known as KIAA1530)
|
|
2175
|
+
cause UVSS-A. The UVSSA protein interacts with TC-NER machinery and stabilizes
|
|
2176
|
+
the ERCC6 complex; it also facilitates ubiquitination of RNA polymerase IIo
|
|
2177
|
+
stalled at DNA damage sites. Our findings provide mechanistic insights into
|
|
2178
|
+
the processing of stalled RNA polymerase and explain the different clinical
|
|
2179
|
+
features across these TC-NER-deficient disorders.</abstract><summary>UV-sensitive
|
|
2180
|
+
syndrome (UVSS) is a genodermatosis characterized by cutaneous photosensitivity
|
|
2181
|
+
without skin carcinoma. Despite mild clinical features, cells from individuals
|
|
2182
|
+
with UVSS, like Cockayne syndrome cells, are very UV sensitive and are deficient
|
|
2183
|
+
in transcription-coupled nucleotide-excision repair (TC-NER), which removes
|
|
2184
|
+
DNA damage in actively transcribed genes. Three of the seven known UVSS cases
|
|
2185
|
+
carry mutations in the Cockayne syndrome genes ERCC8 or ERCC6 (also known
|
|
2186
|
+
as CSA and CSB, respectively). The remaining four individuals with UVSS, one
|
|
2187
|
+
of whom is described for the first time here, formed a separate UVSS-A complementation
|
|
2188
|
+
group; however, the responsible gene was unknown. Using exome sequencing,
|
|
2189
|
+
we determine that mutations in the UVSSA gene (formerly known as KIAA1530)
|
|
2190
|
+
cause UVSS-A. The UVSSA protein interacts with TC-NER machinery and stabilizes
|
|
2191
|
+
the ERCC6 complex; it also facilitates ubiquitination of RNA polymerase IIo
|
|
2192
|
+
stalled at DNA damage sites. Our findings provide mechanistic insights into
|
|
2193
|
+
the processing of stalled RNA polymerase and explain the different clinical
|
|
2194
|
+
features across these TC-NER-deficient disorders.</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=5</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000014</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000014</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00297917&rft.date=2012&rft.tpages=2+pages&rft.jtitle=Occupational+Health&rft.volume=64&rft.issue=5&rft.spage=14&rft.epage=15&rft.atitle=Inhalation+versus+skin+exposure+%3A+have+we+got+the+balance+right%3F+&rft.aulast=Packham&rft.aufirst=Chris+Partner%2C+EnviroDerm+Services</openurl_kev_co><xerxes_record><title_normalized>Inhalation
|
|
2195
|
+
Versus Skin Exposure: Have We Got the Balance Right?</title_normalized><journal_title>Occupational
|
|
2196
|
+
Health</journal_title><primary_author>Packham, Chris Partner, EnviroDerm Services
|
|
2197
|
+
</primary_author><authors><author type=\"personal\" rank=\"1\"><aulast>Packham</aulast><aufirst>Chris
|
|
2198
|
+
Partner, EnviroDerm Services</aufirst><display>Packham, Chris Partner, EnviroDerm
|
|
2199
|
+
Services</display></author></authors><standard_numbers><issn>00297917</issn></standard_numbers><links><link
|
|
2200
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=75125836&site=ehost-live</url></link></links><subjects><subject
|
|
2201
|
+
value=\"Great Britain\">Great Britain</subject><subject value=\"World Health
|
|
2202
|
+
Organization\">World Health Organization</subject><subject value=\"Protective
|
|
2203
|
+
clothing\">Protective clothing</subject><subject value=\"Skin -- Diseases\">Skin
|
|
2204
|
+
-- Diseases</subject><subject value=\"Spirometry\">Spirometry</subject><subject
|
|
2205
|
+
value=\"Environmental exposure\">Environmental exposure</subject><subject
|
|
2206
|
+
value=\"Skin -- Diseases -- Prevention\">Skin -- Diseases -- Prevention</subject><subject
|
|
2207
|
+
value=\"Industrial safety -- Great Britain\">Industrial safety -- Great Britain</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000014</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2208
|
+
Full Text Mega</database_name><format>Article</format><title>Inhalation versus
|
|
2209
|
+
skin exposure</title><sub_title>have we got the balance right?</sub_title><year>2012</year><extent>2
|
|
2210
|
+
pages</extent><journal>Occupational Health vol.64 no.5 pp.14-15</journal><volume>64</volume><issue>5</issue><start_page>14</start_page><end_page>15</end_page><description>2
|
|
2211
|
+
pages Publication type:Academic Journal</description><summary>Great Britain;
|
|
2212
|
+
World Health Organization; Protective clothing; Skin -- Diseases; Spirometry;
|
|
2213
|
+
Environmental exposure; Skin -- Diseases -- Prevention; Industrial safety
|
|
2214
|
+
-- Great Britain</summary><summary_type>subjects</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=6</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000016</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000016</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00284793&rft.date=2012&rft.tpages=7+pages&rft.jtitle=New+England+Journal+of+Medicine&rft.volume=366&rft.issue=16&rft.spage=1508&rft.epage=1514&rft.atitle=Integrin+%CE%B13+Mutations+with+Kidney%2C+Lung%2C+and+Skin+Disease+&rft.aulast=Has&rft.aufirst=Cristina</openurl_kev_co><xerxes_record><title_normalized>Integrin
|
|
2215
|
+
α3 Mutations with Kidney, Lung, and Skin Disease</title_normalized><journal_title>New
|
|
2216
|
+
England Journal of Medicine</journal_title><primary_author>Has, Cristina </primary_author><authors><author
|
|
2217
|
+
type=\"personal\" rank=\"1\"><aulast>Has</aulast><aufirst>Cristina</aufirst><display>Has,
|
|
2218
|
+
Cristina</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Spartà</aulast><aufirst>Giuseppina</aufirst><display>Spartà,
|
|
2219
|
+
Giuseppina</display></author><author type=\"personal\" additional=\"true\"
|
|
2220
|
+
rank=\"3\"><aulast>Kiritsi</aulast><aufirst>Dimitra</aufirst><display>Kiritsi,
|
|
2221
|
+
Dimitra</display></author><author type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Weibel</aulast><aufirst>Lisa</aufirst><display>Weibel,
|
|
2222
|
+
Lisa</display></author><author type=\"personal\" additional=\"true\" rank=\"5\"><aulast>Moeller</aulast><aufirst>Alexander</aufirst><display>Moeller,
|
|
2223
|
+
Alexander</display></author><author type=\"personal\" additional=\"true\"
|
|
2224
|
+
rank=\"6\"><aulast>Vega-Warner</aulast><aufirst>Virginia</aufirst><display>Vega-Warner,
|
|
2225
|
+
Virginia</display></author><author type=\"personal\" additional=\"true\" rank=\"7\"><aulast>Waters</aulast><aufirst>Aoife</aufirst><display>Waters,
|
|
2226
|
+
Aoife</display></author><author type=\"personal\" additional=\"true\" rank=\"8\"><aulast>He</aulast><aufirst>Yinghong</aufirst><display>He,
|
|
2227
|
+
Yinghong</display></author><author type=\"personal\" additional=\"true\" rank=\"9\"><aulast>Anikster</aulast><aufirst>Yair</aufirst><display>Anikster,
|
|
2228
|
+
Yair</display></author><author type=\"personal\" additional=\"true\" rank=\"10\"><aulast>Esser</aulast><aufirst>Philipp</aufirst><display>Esser,
|
|
2229
|
+
Philipp</display></author><author type=\"personal\" additional=\"true\" rank=\"11\"><aulast>Straub</aulast><aufirst>Beate</aufirst><auinit>K</auinit><display>Straub,
|
|
2230
|
+
Beate K</display></author><author type=\"personal\" additional=\"true\" rank=\"12\"><aulast>Hausser</aulast><aufirst>Ingrid</aufirst><display>Hausser,
|
|
2231
|
+
Ingrid</display></author><author type=\"personal\" additional=\"true\" rank=\"13\"><aulast>Bockenhauer</aulast><aufirst>Detlef</aufirst><display>Bockenhauer,
|
|
2232
|
+
Detlef</display></author><author type=\"personal\" additional=\"true\" rank=\"14\"><aulast>Dekel</aulast><aufirst>Benjamin</aufirst><display>Dekel,
|
|
2233
|
+
Benjamin</display></author><author type=\"personal\" additional=\"true\" rank=\"15\"><aulast>Hildebrandt</aulast><aufirst>Friedhelm</aufirst><display>Hildebrandt,
|
|
2234
|
+
Friedhelm</display></author><author type=\"personal\" additional=\"true\"
|
|
2235
|
+
rank=\"16\"><aulast>Bruckner-Tuderman</aulast><aufirst>Leena</aufirst><display>Bruckner-Tuderman,
|
|
2236
|
+
Leena</display></author><author type=\"personal\" additional=\"true\" rank=\"17\"><aulast>Laube</aulast><aufirst>Guido</aufirst><auinit>F</auinit><display>Laube,
|
|
2237
|
+
Guido F</display></author></authors><standard_numbers><issn>00284793</issn></standard_numbers><links><link
|
|
2238
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=74413057&site=ehost-live</url></link></links><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000016</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2239
|
+
Full Text Mega</database_name><format>Article</format><title>Integrin α3
|
|
2240
|
+
Mutations with Kidney, Lung, and Skin Disease</title><year>2012</year><extent>7
|
|
2241
|
+
pages</extent><journal>New England Journal of Medicine vol.366 no.16 pp.1508-1514</journal><volume>366</volume><issue>16</issue><start_page>1508</start_page><end_page>1514</end_page><description>7
|
|
2242
|
+
pages Publication type:Academic Journal</description><abstract>: Integrin
|
|
2243
|
+
α3 is a transmembrane integrin receptor subunit that mediates signals
|
|
2244
|
+
between the cells and their microenvironment. We identified three patients
|
|
2245
|
+
with homozygous mutations in the integrin α3 gene that were associated
|
|
2246
|
+
with disrupted basement-membrane structures and compromised barrier functions
|
|
2247
|
+
in kidney, lung, and skin. The patients had a multiorgan disorder that included
|
|
2248
|
+
congenital nephrotic syndrome, interstitial lung disease, and epidermolysis
|
|
2249
|
+
bullosa. The renal and respiratory features predominated, and the lung involvement
|
|
2250
|
+
accounted for the lethal course of the disease. Although skin fragility was
|
|
2251
|
+
mild, it provided clues to the diagnosis.</abstract><summary>: Integrin α3
|
|
2252
|
+
is a transmembrane integrin receptor subunit that mediates signals between
|
|
2253
|
+
the cells and their microenvironment. We identified three patients with homozygous
|
|
2254
|
+
mutations in the integrin α3 gene that were associated with disrupted
|
|
2255
|
+
basement-membrane structures and compromised barrier functions in kidney,
|
|
2256
|
+
lung, and skin. The patients had a multiorgan disorder that included congenital
|
|
2257
|
+
nephrotic syndrome, interstitial lung disease, and epidermolysis bullosa.
|
|
2258
|
+
The renal and respiratory features predominated, and the lung involvement
|
|
2259
|
+
accounted for the lethal course of the disease. Although skin fragility was
|
|
2260
|
+
mild, it provided clues to the diagnosis.</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=7</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000018</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000018</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00284793&rft.date=2012&rft.tpages=5+pages&rft.jtitle=New+England+Journal+of+Medicine&rft.volume=366&rft.issue=14&rft.spage=1336&rft.epage=1340&rft.atitle=Skin+Deep+&rft.aulast=Safdar&rft.aufirst=Nasia</openurl_kev_co><xerxes_record><title_normalized>Skin
|
|
2261
|
+
Deep</title_normalized><journal_title>New England Journal of Medicine</journal_title><primary_author>Safdar,
|
|
2262
|
+
Nasia </primary_author><authors><author type=\"personal\" rank=\"1\"><aulast>Safdar</aulast><aufirst>Nasia</aufirst><display>Safdar,
|
|
2263
|
+
Nasia</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Abad</aulast><aufirst>Cybele</aufirst><auinit>L</auinit><display>Abad,
|
|
2264
|
+
Cybele L</display></author><author type=\"personal\" additional=\"true\" rank=\"3\"><aulast>Kaul</aulast><aufirst>Daniel</aufirst><auinit>R</auinit><display>Kaul,
|
|
2265
|
+
Daniel R</display></author><author type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Saint</aulast><aufirst>Sanjay
|
|
2266
|
+
Department of Medicine, University of Wisconsin–Madison School of Medicine,
|
|
2267
|
+
Madison Early Intervention Program Clinic, Milwaukee Health Services, Milwaukee
|
|
2268
|
+
Department of Internal Medicine, University of Michigan Medical School, Ann
|
|
2269
|
+
Arbor Department of Veterans Affairs Health Services Research and Development
|
|
2270
|
+
Center of Excellence, Ann Arbor</aufirst><display>Saint, Sanjay Department
|
|
2271
|
+
of Medicine, University of Wisconsin–Madison School of Medicine, Madison
|
|
2272
|
+
Early Intervention Program Clinic, Milwaukee Health Services, Milwaukee Department
|
|
2273
|
+
of Internal Medicine, University of Michigan Medical School, Ann Arbor Department
|
|
2274
|
+
of Veterans Affairs Health Services Research and Development Center of Excellence,
|
|
2275
|
+
Ann Arbor</display></author></authors><standard_numbers><issn>00284793</issn></standard_numbers><links><link
|
|
2276
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=74078177&site=ehost-live</url></link></links><subjects><subject
|
|
2277
|
+
value=\"Case studies\">Case studies</subject><subject value=\"Skin -- Diseases\">Skin
|
|
2278
|
+
-- Diseases</subject><subject value=\"Mycobacterial diseases\">Mycobacterial
|
|
2279
|
+
diseases</subject><subject value=\"Bacterial diseases\">Bacterial diseases</subject><subject
|
|
2280
|
+
value=\"Carpal tunnel syndrome\">Carpal tunnel syndrome</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000018</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2281
|
+
Full Text Mega</database_name><format>Article</format><title>Skin Deep</title><year>2012</year><extent>5
|
|
2282
|
+
pages</extent><journal>New England Journal of Medicine vol.366 no.14 pp.1336-1340</journal><volume>366</volume><issue>14</issue><start_page>1336</start_page><end_page>1340</end_page><description>5
|
|
2283
|
+
pages Publication type:Academic Journal</description><abstract>The article
|
|
2284
|
+
describes the case of a 56-year-old woman diagnosed with cutaneous mycobacterial
|
|
2285
|
+
infection. The patient presented with symptoms of carpal tunnel syndrome for
|
|
2286
|
+
6 months and was referred to a clinic with nodular lesions on her right forearm
|
|
2287
|
+
and hand that had appeared 4 months before consultation. An overview of the
|
|
2288
|
+
medical history of the patient is presented. Also given is a discussion on
|
|
2289
|
+
the causes of chronic nodular lesions.</abstract><summary>The article describes
|
|
2290
|
+
the case of a 56-year-old woman diagnosed with cutaneous mycobacterial infection.
|
|
2291
|
+
The patient presented with symptoms of carpal tunnel syndrome for 6 months
|
|
2292
|
+
and was referred to a clinic with nodular lesions on her right forearm and
|
|
2293
|
+
hand that had appeared 4 months before consultation. An overview of the medical
|
|
2294
|
+
history of the patient is presented. Also given is a discussion on the causes
|
|
2295
|
+
of chronic nodular lesions.</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nCase
|
|
2296
|
+
Study\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=8</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000027</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000027</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00280836&rft.date=2012&rft.tpages=5+pages&rft.jtitle=Nature&rft.volume=483&rft.issue=7388&rft.spage=227&rft.epage=231&rft.atitle=Skin+infection+generates+non-migratory+memory+CD8%2B+TRM+cells+providing+global+skin+immunity+&rft.aulast=Jiang&rft.aufirst=Xiaodong</openurl_kev_co><xerxes_record><title_normalized>Skin
|
|
2297
|
+
Infection Generates Non-migratory Memory CD8+ TRM Cells Providing Global Skin
|
|
2298
|
+
Immunity</title_normalized><journal_title>Nature</journal_title><primary_author>Jiang,
|
|
2299
|
+
Xiaodong </primary_author><authors><author type=\"personal\" rank=\"1\"><aulast>Jiang</aulast><aufirst>Xiaodong</aufirst><display>Jiang,
|
|
2300
|
+
Xiaodong</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Clark</aulast><aufirst>Rachael</aufirst><auinit>A</auinit><display>Clark,
|
|
2301
|
+
Rachael A</display></author><author type=\"personal\" additional=\"true\"
|
|
2302
|
+
rank=\"3\"><aulast>Liu</aulast><aufirst>Luzheng</aufirst><display>Liu, Luzheng</display></author><author
|
|
2303
|
+
type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Wagers</aulast><aufirst>Amy</aufirst><auinit>J</auinit><display>Wagers,
|
|
2304
|
+
Amy J</display></author><author type=\"personal\" additional=\"true\" rank=\"5\"><aulast>Fuhlbrigge</aulast><aufirst>Robert</aufirst><auinit>C</auinit><display>Fuhlbrigge,
|
|
2305
|
+
Robert C</display></author><author type=\"personal\" additional=\"true\" rank=\"6\"><aulast>Kupper</aulast><aufirst>Thomas
|
|
2306
|
+
S. Department of Dermatology and Harvard Skin Disease Research Center, Brigham
|
|
2307
|
+
and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,
|
|
2308
|
+
USA Department of Stem Cell and Regenerative Biology, Harvard University,
|
|
2309
|
+
Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes
|
|
2310
|
+
Center, Boston, Massachusetts 02115, USA</aufirst><display>Kupper, Thomas
|
|
2311
|
+
S. Department of Dermatology and Harvard Skin Disease Research Center, Brigham
|
|
2312
|
+
and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115,
|
|
2313
|
+
USA Department of Stem Cell and Regenerative Biology, Harvard University,
|
|
2314
|
+
Howard Hughes Medical Institute, Harvard Stem Cell Institute, Joslin Diabetes
|
|
2315
|
+
Center, Boston, Massachusetts 02115, USA</display></author></authors><standard_numbers><issn>00280836</issn></standard_numbers><links><link
|
|
2316
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=72680207&site=ehost-live</url></link></links><subjects><subject
|
|
2317
|
+
value=\"Skin -- Infections\">Skin -- Infections</subject><subject value=\"T
|
|
2318
|
+
cells\">T cells</subject><subject value=\"Immunologic memory\">Immunologic
|
|
2319
|
+
memory</subject><subject value=\"Vaccinia\">Vaccinia</subject><subject value=\"Mice
|
|
2320
|
+
as laboratory animals\">Mice as laboratory animals</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000027</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2321
|
+
Full Text Mega</database_name><format>Article</format><title>Skin infection
|
|
2322
|
+
generates non-migratory memory CD8+ TRM cells providing global skin immunity</title><year>2012</year><extent>5
|
|
2323
|
+
pages</extent><journal>Nature vol.483 no.7388 pp.227-231</journal><volume>483</volume><issue>7388</issue><start_page>227</start_page><end_page>231</end_page><description>5
|
|
2324
|
+
pages Publication type:Academic Journal</description><abstract>Protective
|
|
2325
|
+
T-cell memory has long been thought to reside in blood and lymph nodes, but
|
|
2326
|
+
recently the concept of immune memory in peripheral tissues mediated by resident
|
|
2327
|
+
memory T (TRM) cells has been proposed. Here we show in mice that localized
|
|
2328
|
+
vaccinia virus (VACV) skin infection generates long-lived non-recirculating
|
|
2329
|
+
CD8+ skin TRM cells that reside within the entire skin. These skin TRM cells
|
|
2330
|
+
are potent effector cells, and are superior to circulating central memory
|
|
2331
|
+
T (TCM) cells at providing rapid long-term protection against cutaneous re-infection.
|
|
2332
|
+
We find that CD8+ T cells are rapidly recruited to skin after acute VACV infection.
|
|
2333
|
+
CD8+ T-cell recruitment to skin is independent of CD4+ T cells and interferon-?,
|
|
2334
|
+
but requires the expression of E- and P-selectin ligands by CD8+ T cells.
|
|
2335
|
+
Using parabiotic mice, we further show that circulating CD8+ TCM and CD8+
|
|
2336
|
+
skin TRM cells are both generated after skin infection; however, CD8+ TCM
|
|
2337
|
+
cells recirculate between blood and lymph nodes whereas TRM cells remain in
|
|
2338
|
+
the skin. Cutaneous CD8+ TRM cells produce effector cytokines and persist
|
|
2339
|
+
for at least 6 months after infection. Mice with CD8+ skin TRM cells rapidly
|
|
2340
|
+
cleared a subsequent re-infection with VACV whereas mice with circulating
|
|
2341
|
+
TCM but no skin TRM cells showed greatly impaired viral clearance, indicating
|
|
2342
|
+
that TRM cells provide superior protection. Finally, we show that TRM cells
|
|
2343
|
+
generated as a result of localized VACV skin infection reside not only in
|
|
2344
|
+
the site of infection, but also populate the entire skin surface and remain
|
|
2345
|
+
present for many months. Repeated re-infections lead to progressive accumulation
|
|
2346
|
+
of highly protective TRM cells in non-involved skin. These findings have important
|
|
2347
|
+
implications for our understanding of protective immune memory at epithelial
|
|
2348
|
+
interfaces with the environment, and suggest novel strategies for vaccines
|
|
2349
|
+
that protect against tissue tropic organisms.</abstract><summary>Protective
|
|
2350
|
+
T-cell memory has long been thought to reside in blood and lymph nodes, but
|
|
2351
|
+
recently the concept of immune memory in peripheral tissues mediated by resident
|
|
2352
|
+
memory T (TRM) cells has been proposed. Here we show in mice that localized
|
|
2353
|
+
vaccinia virus (VACV) skin infection generates long-lived non-recirculating
|
|
2354
|
+
CD8+ skin TRM cells that reside within the entire skin. These skin TRM cells
|
|
2355
|
+
are potent effector cells, and are superior to circulating central memory
|
|
2356
|
+
T (TCM) cells at providing rapid long-term protection against cutaneous re-infection.
|
|
2357
|
+
We find that CD8+ T cells are rapidly recruited to skin after acute VACV infection.
|
|
2358
|
+
CD8+ T-cell recruitment to skin is independent of CD4+ T cells and interferon-?,
|
|
2359
|
+
but requires the expression of E- and P-selectin ligands by CD8+ T cells.
|
|
2360
|
+
Using parabiotic mice, we further show that circulating CD8+ TCM and CD8+
|
|
2361
|
+
skin TRM cells are both generated after skin infection; however, CD8+ TCM
|
|
2362
|
+
cells recirculate between blood and lymph nodes whereas TRM cells remain in
|
|
2363
|
+
the skin. Cutaneous CD8+ TRM cells produce effector cytokines and persist
|
|
2364
|
+
for at least 6 months after infection. Mice with CD8+ skin TRM cells rapidly
|
|
2365
|
+
cleared a subsequent re-infection with VACV whereas mice with circulating
|
|
2366
|
+
TCM but no skin TRM cells showed greatly impaired viral clearance, indicating
|
|
2367
|
+
that TRM cells provide superior protection. Finally, we show that TRM cells
|
|
2368
|
+
generated as a result of localized VACV skin infection reside not only in
|
|
2369
|
+
the site of infection, but also populate the entire skin surface and remain
|
|
2370
|
+
present for many months. Repeated re-infections lead to progressive accumulation
|
|
2371
|
+
of highly protective TRM cells in non-involved skin. These findings have important
|
|
2372
|
+
implications for our understanding of protective immune memory at epithelial
|
|
2373
|
+
interfaces with the environment, and suggest novel strategies for vaccines
|
|
2374
|
+
that protect against tissue tropic organisms.</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=9</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004874&startRecord=000012</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004874&startRecord=000012</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+Academic+Search+Complete%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=01054538&rft.date=2012&rft.jtitle=Allergy&rft.volume=67&rft.issue=6&rft.spage=813&rft.epage=821&rft.atitle=Increased+serum+baseline+tryptase+levels+and+extensive+skin+involvement+are+predictors+for+the+severity+of+mast+cell+activation+episodes+in+children+with+mastocytosis+&rft.aulast=Alvarez-Twose&rft.aufirst=I</openurl_kev_co><xerxes_record><title_normalized>Increased
|
|
2375
|
+
Serum Baseline Tryptase Levels and Extensive Skin Involvement Are Predictors
|
|
2376
|
+
for the Severity of Mast Cell Activation Episodes in Children with Mastocytosis</title_normalized><journal_title>Allergy</journal_title><primary_author>Alvarez-Twose,
|
|
2377
|
+
I </primary_author><authors><author type=\"personal\" rank=\"1\"><aulast>Alvarez-Twose</aulast><aufirst>I</aufirst><display>Alvarez-Twose,
|
|
2378
|
+
I. 1,2</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Vano-Galvan</aulast><aufirst>S</aufirst><display>Vano-Galvan,
|
|
2379
|
+
S. 3</display></author><author type=\"personal\" additional=\"true\" rank=\"3\"><aulast>Sanchez-Munoz</aulast><aufirst>L</aufirst><display>Sanchez-Munoz,
|
|
2380
|
+
L. 1,2</display></author><author type=\"personal\" additional=\"true\" rank=\"4\"><aulast>Morgado</aulast><aufirst>J</aufirst><auinit>M</auinit><display>Morgado,
|
|
2381
|
+
J. M. 1,2</display></author><author type=\"personal\" additional=\"true\"
|
|
2382
|
+
rank=\"5\"><aulast>Matito</aulast><aufirst>A</aufirst><display>Matito, A.
|
|
2383
|
+
1,2</display></author><author type=\"personal\" additional=\"true\" rank=\"6\"><aulast>Torrelo</aulast><aufirst>A</aufirst><display>Torrelo,
|
|
2384
|
+
A. 4</display></author><author type=\"personal\" additional=\"true\" rank=\"7\"><aulast>Jaen</aulast><aufirst>P</aufirst><display>Jaen,
|
|
2385
|
+
P. 3</display></author><author type=\"personal\" additional=\"true\" rank=\"8\"><aulast>Schwartz</aulast><aufirst>L</aufirst><auinit>B</auinit><display>Schwartz,
|
|
2386
|
+
L. B. 5</display></author><author type=\"personal\" additional=\"true\" rank=\"9\"><aulast>Orfao</aulast><aufirst>A</aufirst><display>Orfao,
|
|
2387
|
+
A. 2,6</display></author><author type=\"personal\" additional=\"true\" rank=\"10\"><aulast>Escribano</aulast><aufirst>L</aufirst><display>Escribano,
|
|
2388
|
+
L. 1,2</display></author></authors><standard_numbers><issn>01054538</issn></standard_numbers><links><link
|
|
2389
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&an=75061718&db=a9h&scope=site</url></link></links><subjects><subject
|
|
2390
|
+
value=\"mast cell\">mast cell</subject><subject value=\"mastocytosis, pediatric\">mastocytosis,
|
|
2391
|
+
pediatric</subject><subject value=\"skin\">skin</subject><subject value=\"tryptase\">tryptase</subject><subject
|
|
2392
|
+
value=\"MAST cell disease\">MAST cell disease</subject><subject value=\"SKIN
|
|
2393
|
+
-- Diseases\">SKIN -- Diseases</subject><subject value=\"TRYPTASE\">TRYPTASE</subject><subject
|
|
2394
|
+
value=\"INTENSIVE care units\">INTENSIVE care units</subject><subject value=\"PEDIATRICS\">PEDIATRICS</subject></subjects><metalib_id>JHU04066</metalib_id><result_set>004874</result_set><record_number>000012</record_number><source>EBSCO_A9H</source><database_name>Academic
|
|
2395
|
+
Search Complete</database_name><record_id>75061718</record_id><format>Article</format><control_number>75061718</control_number><title>Increased
|
|
2396
|
+
serum baseline tryptase levels and extensive skin involvement are predictors
|
|
2397
|
+
for the severity of mast cell activation episodes in children with mastocytosis</title><year>2012</year><journal>Allergy
|
|
2398
|
+
Jun2012, Vol. 67 Issue 6, p813-821 9p 01054538</journal><volume>67</volume><issue>6</issue><start_page>813</start_page><end_page>821</end_page><abstract>Background
|
|
2399
|
+
Despite the good prognosis of pediatric mastocytosis, some patients suffer
|
|
2400
|
+
from severe mast cell ( MC) mediator-associated symptoms. The aim of this
|
|
2401
|
+
study was to identify predictors for severe MC mediator release symptoms in
|
|
2402
|
+
children with mastocytosis in the skin ( MIS). Methods Serum baseline total
|
|
2403
|
+
tryptase (sb T) levels in 111 children with MIS - 80 maculopapular cutaneous
|
|
2404
|
+
mastocytosis/plaque mastocytosis, 22 nodular mastocytosis, and nine diffuse
|
|
2405
|
+
cutaneous mastocytosis - were investigated as a predictive biomarker for the
|
|
2406
|
+
occurrence of MC mediator-related signs and symptoms within the first 18 months
|
|
2407
|
+
after disease onset. Results Twelve children (11%) who showed extensive cutaneous
|
|
2408
|
+
disease involving >90% of body surface area ( BSA) suffered from severe
|
|
2409
|
+
symptoms requiring hospitalization, with ( n = 5) or without ( n = 6) management
|
|
2410
|
+
in the intensive care unit ( ICU) owing to life-threatening complications.
|
|
2411
|
+
The median sbT was significantly ( P < 0.001) higher in patients^ with
|
|
2412
|
+
extensive cutaneous disease vs those with</abstract><summary>Background Despite
|
|
2413
|
+
the good prognosis of pediatric mastocytosis, some patients suffer from severe
|
|
2414
|
+
mast cell ( MC) mediator-associated symptoms. The aim of this study was to
|
|
2415
|
+
identify predictors for severe MC mediator release symptoms in children with
|
|
2416
|
+
mastocytosis in the skin ( MIS). Methods Serum baseline total tryptase (sb
|
|
2417
|
+
T) levels in 111 children with MIS - 80 maculopapular cutaneous mastocytosis/plaque
|
|
2418
|
+
mastocytosis, 22 nodular mastocytosis, and nine diffuse cutaneous mastocytosis
|
|
2419
|
+
- were investigated as a predictive biomarker for the occurrence of MC mediator-related
|
|
2420
|
+
signs and symptoms within the first 18 months after disease onset. Results
|
|
2421
|
+
Twelve children (11%) who showed extensive cutaneous disease involving >90%
|
|
2422
|
+
of body surface area ( BSA) suffered from severe symptoms requiring hospitalization,
|
|
2423
|
+
with ( n = 5) or without ( n = 6) management in the intensive care unit (
|
|
2424
|
+
ICU) owing to life-threatening complications. The median sbT was significantly
|
|
2425
|
+
( P < 0.001) higher in patients^ with extensive cutaneous disease vs those
|
|
2426
|
+
with</summary><summary_type>abstract</summary_type><notes><note>\nUncontrolled
|
|
2427
|
+
terms\nEnglish\n</note></notes></xerxes_record></record><record><url_full>/metasearch/record?group=2012-05-22-000249&resultSet=004877&startRecord=10</url_full><url_save_delete>/metasearch/save-delete?group=2012-05-22-000249&resultSet=004875&startRecord=000026</url_save_delete><url_open>/metasearch/sfx?group=2012-05-22-000249&resultSet=004875&startRecord=000026</url_open><openurl_kev_co>url_ver=Z39.88-2004&rfr_id=info:sid/library.jhu.edu%3Axerxes+%28+OmniFile+Full+Text+Mega%29&rft.genre=article&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.issn=00284793&rft.date=2012&rft.tpages=10+pages&rft.jtitle=New+England+Journal+of+Medicine&rft.volume=366&rft.issue=11&rft.spage=1010&rft.epage=1019&rft.atitle=Ingenol+Mebutate+Gel+for+Actinic+Keratosis+&rft.aulast=Lebwohl&rft.aufirst=Mark</openurl_kev_co><xerxes_record><title_normalized>Ingenol
|
|
2428
|
+
Mebutate Gel for Actinic Keratosis</title_normalized><journal_title>New England
|
|
2429
|
+
Journal of Medicine</journal_title><primary_author>Lebwohl, Mark </primary_author><authors><author
|
|
2430
|
+
type=\"personal\" rank=\"1\"><aulast>Lebwohl</aulast><aufirst>Mark</aufirst><display>Lebwohl,
|
|
2431
|
+
Mark</display></author><author type=\"personal\" additional=\"true\" rank=\"2\"><aulast>Swanson</aulast><aufirst>Neil</aufirst><display>Swanson,
|
|
2432
|
+
Neil</display></author><author type=\"personal\" additional=\"true\" rank=\"3\"><aulast>Anderson</aulast><aufirst>Lawrence</aufirst><auinit>L</auinit><display>Anderson,
|
|
2433
|
+
Lawrence L</display></author><author type=\"personal\" additional=\"true\"
|
|
2434
|
+
rank=\"4\"><aulast>Melgaard</aulast><aufirst>Anita</aufirst><display>Melgaard,
|
|
2435
|
+
Anita</display></author><author type=\"personal\" additional=\"true\" rank=\"5\"><aulast>Xu</aulast><aufirst>Zhenyi</aufirst><display>Xu,
|
|
2436
|
+
Zhenyi</display></author><author type=\"personal\" additional=\"true\" rank=\"6\"><aulast>Berman</aulast><aufirst>Brian
|
|
2437
|
+
Department of Dermatology, Mount Sinai School of Medicine, New York Department
|
|
2438
|
+
of Dermatology, Oregon Health and Science University, Portland Dermatology
|
|
2439
|
+
Associates of Tyler, Tyler, TX Department of Biostatistics and Data Management,
|
|
2440
|
+
LEO Pharma, Ballerup, Denmark Medical Department, LEO Pharma, Ballerup, Denmark;
|
|
2441
|
+
Department of Dermatology and Cutaneous Surgery, University of Miami Miller
|
|
2442
|
+
School of Medicine, Miami</aufirst><display>Berman, Brian Department of Dermatology,
|
|
2443
|
+
Mount Sinai School of Medicine, New York Department of Dermatology, Oregon
|
|
2444
|
+
Health and Science University, Portland Dermatology Associates of Tyler, Tyler,
|
|
2445
|
+
TX Department of Biostatistics and Data Management, LEO Pharma, Ballerup,
|
|
2446
|
+
Denmark Medical Department, LEO Pharma, Ballerup, Denmark; Department of Dermatology
|
|
2447
|
+
and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami</display></author></authors><standard_numbers><issn>00284793</issn></standard_numbers><links><link
|
|
2448
|
+
type=\"original_record\"><display></display><url>http://search.ebscohost.com/login.aspx?direct=true&db=ofm&AN=73354516&site=ehost-live</url></link></links><subjects><subject
|
|
2449
|
+
value=\"Squamous cell carcinoma\">Squamous cell carcinoma</subject><subject
|
|
2450
|
+
value=\"Drugs -- Effectiveness\">Drugs -- Effectiveness</subject><subject
|
|
2451
|
+
value=\"Placebos (Medicine)\">Placebos (Medicine)</subject><subject value=\"Actinic
|
|
2452
|
+
keratosis\">Actinic keratosis</subject><subject value=\"Skin -- Diseases --
|
|
2453
|
+
Treatment\">Skin -- Diseases -- Treatment</subject></subjects><metalib_id>JHU06614</metalib_id><result_set>004875</result_set><record_number>000026</record_number><source>EBSCO_XML</source><database_name>OmniFile
|
|
2454
|
+
Full Text Mega</database_name><format>Article</format><title>Ingenol Mebutate
|
|
2455
|
+
Gel for Actinic Keratosis</title><year>2012</year><extent>10 pages</extent><journal>New
|
|
2456
|
+
England Journal of Medicine vol.366 no.11 pp.1010-1019</journal><volume>366</volume><issue>11</issue><start_page>1010</start_page><end_page>1019</end_page><description>10
|
|
2457
|
+
pages Publication type:Academic Journal</description><abstract>Background:
|
|
2458
|
+
Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma.
|
|
2459
|
+
Treating actinic keratoses and the surrounding skin area (i.e., field therapy)
|
|
2460
|
+
can eradicate clinical and subclinical actinic keratoses. Topical field therapy
|
|
2461
|
+
currently requires weeks or months of treatment. We investigated the efficacy
|
|
2462
|
+
and safety of a new topical field therapy for actinic keratosis, ingenol mebutate
|
|
2463
|
+
gel (0.015% for face and scalp and 0.05% for trunk and extremities). Methods:
|
|
2464
|
+
In four multicenter, randomized, double-blind studies, we randomly assigned
|
|
2465
|
+
patients with actinic keratoses on the face or scalp or on the trunk or extremities
|
|
2466
|
+
to receive ingenol mebutate or placebo (vehicle), self-applied to a 25-cm2
|
|
2467
|
+
contiguous field once daily for 3 consecutive days for lesions on the face
|
|
2468
|
+
or scalp or for 2 consecutive days for the trunk or extremities. Complete
|
|
2469
|
+
clearance (primary outcome) was assessed at 57 days, and local reactions were
|
|
2470
|
+
quantitatively measured. Results: In a pooled analysis of the two trials involving
|
|
2471
|
+
the face and scalp, the rate of complete clearance was higher with ingenol
|
|
2472
|
+
mebutate than with placebo (42.2% vs. 3.7%, P</abstract><summary>Background:
|
|
2473
|
+
Actinic keratosis is a common precursor to sun-related squamous-cell carcinoma.
|
|
2474
|
+
Treating actinic keratoses and the surrounding skin area (i.e., field therapy)
|
|
2475
|
+
can eradicate clinical and subclinical actinic keratoses. Topical field therapy
|
|
2476
|
+
currently requires weeks or months of treatment. We investigated the efficacy
|
|
2477
|
+
and safety of a new topical field therapy for actinic keratosis, ingenol mebutate
|
|
2478
|
+
gel (0.015% for face and scalp and 0.05% for trunk and extremities). Methods:
|
|
2479
|
+
In four multicenter, randomized, double-blind studies, we randomly assigned
|
|
2480
|
+
patients with actinic keratoses on the face or scalp or on the trunk or extremities
|
|
2481
|
+
to receive ingenol mebutate or placebo (vehicle), self-applied to a 25-cm2
|
|
2482
|
+
contiguous field once daily for 3 consecutive days for lesions on the face
|
|
2483
|
+
or scalp or for 2 consecutive days for the trunk or extremities. Complete
|
|
2484
|
+
clearance (primary outcome) was assessed at 57 days, and local reactions were
|
|
2485
|
+
quantitatively measured. Results: In a pooled analysis of the two trials involving
|
|
2486
|
+
the face and scalp, the rate of complete clearance was higher with ingenol
|
|
2487
|
+
mebutate than with placebo (42.2% vs. 3.7%, P</summary><summary_type>abstract</summary_type><language>English</language><notes><note>\nArticle\n</note></notes></xerxes_record></record></records><cluster_facet_response><cluster_facet
|
|
2488
|
+
name=\"TOPIC\" position=\"1\"><no_of_nodes>000000044</no_of_nodes><node name=\"Cell\"
|
|
2489
|
+
node_level=\"1\" position=\"1\"><node_no_of_docs>14</node_no_of_docs><url>/metasearch/facet?group=2012-05-22-000249&amp;resultSet=004877&amp;facet=1&amp;node=1</url></node><node
|
|
2490
|
+
name=\"University Hospital\" node_level=\"2\" position=\"2\"><node_no_of_docs>4</node_no_of_docs><url>/metasearch/facet?group=2012-05-22-000249&amp;resultSet=004877&amp;facet=1&amp;node=2</url></node><node
|
|
2491
|
+
name=\"Motor Neuron Survival\" node_level=\"2\" position=\"3\"><node_no_of_docs>2</node_no_of_docs><url>/metasearch/facet?group=2012-05-22-000249&amp;resultSet=004877&amp;facet=1&amp;node=3</url></node><node
|
|
2492
|
+
name=\"Mutations in\" node_level=\"2\" position=\"4\"><node_no_of_docs>2</node_no_of_docs><url>/metasearch/facet?group=2012-05-22-000249&amp;resultSet=004877&amp;facet=1&amp;node=4</url></node><node
|
|
2493
|
+
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