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  meta | xiii
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- | Chapter 1
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+ title | Chapter 1
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  title | Introduction
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@@ -646,7 +646,7 @@ text | While the specific geometric priors and prototypes listed abo
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  | standing of the characteristic of the task at hand, the underlying assumptions and
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  | approach provide a direction to allow everyday user to acquire useful 3-D information
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  | in the years to come as real-time 3-D scans become available.
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- meta | Chapter 2
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+ title | Chapter 2
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  title | Interactive Acquisition of
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  | Residential Floor Plans1
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  | to interact directly with the physical world. Here the user adds a window to the room
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  | by dragging a cursor across the wall (left). This motion updates the internal model
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  | of the world (right).
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- meta | Chapter 3
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+ title | Chapter 3
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  title | Acquiring 3D Indoor Environments
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  | with Variability and Repetition2
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- title | Input points Models matched Parts assigned
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+ text | Input points Models matched Parts assigned
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  |
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  |
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  text | Figure 3.14: We compared our algorithm and Koppula et al. [KAJS11] using multiple
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  | frames of scans from the same viewpoint. Our recognition results are more stable
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  | across different frames.
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- meta | Chapter 4
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+ title | Chapter 4
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  title | Guided Real-Time Scanning of
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  | Indoor Objects3
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  | the image of the object being scanned, the accumulated pointcloud, and the closest
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  | shape retrieved model, along with the top 25 candidates that are picked from the
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  | database of thousands of models using the proposed A2h descriptor.
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- meta | Chapter 5
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+ title | Chapter 5
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  title | Conclusions
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@@ -3334,7 +3334,7 @@ text | shape of objects with the help of a large database of 3-D models
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  | would also benefit from the advances made in the use of reliable depth and color
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  | features in the new type of data obtained from the RGB-D sensors in addition to the
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  | presented descriptor.
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- meta | Bibliography
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+ title | Bibliography
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  ref | [BAD10] Soonmin Bae, Aseem Agarwala, and Fredo Durand. Computational
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  | rephotography. ACM Trans. Graph., 29(5), 2010.
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  meta | xxv
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- | Chapter 1
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+ title | Chapter 1
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  title | Introduction
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@@ -875,7 +875,7 @@ text | biophysical descriptions of the tissue behavior and nanoscale de
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  | For the first time, we apply the model to study the disturbances to hydrations due
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  | to the introduction of an intrastromal inlay. A summary of the results and their
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  | implications is given in chapter 8, along with comments on future work.
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- meta | Chapter 2
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+ title | Chapter 2
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  title | An electrolyte model for the ex
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  | vivo cornea
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- text | 2.5.2 Keratocyte and collagen electrolyte volume exclusion
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+ title | 2.5.2 Keratocyte and collagen electrolyte volume exclusion
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  | effects
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- | Predicted electrostatic swelling pressure component Pel , given by equation (2.22), is
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+ text | Predicted electrostatic swelling pressure component Pel , given by equation (2.22), is
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  | plotted against volume dilation J in figure 2.4a for three cases: no volume exclusion,
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  | only collagen volume exclusion, and collagen and keratocyte volume exclusion. The
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  | volume exclusion effects arising from these two stromal components are important for
@@ -1632,7 +1632,7 @@ text | Figure 2.8: The effect of the ϕ and ϕ̂ on the electrostatic f
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  | based and Donnan-based solutions for Pel agree well over the dilation range where
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  | PG-coatings are well separated. The Donnan-based solution P̂el cannot capture the
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  | effect of PG-coating overlap and thus loses accuracy at low hydration.
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- meta | Chapter 3
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+ title | Chapter 3
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  title | Modeling the active endothelial ion
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  | transport in the in vivo cornea
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  | measurements (Olsen and Sperling, 1987). The measured modulus is given by K exp =
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  | 39.12J −4.48 kPa, which is computed by the power law fit function for swelling pressure
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  | Psexp = 7.56t−3.48 mmHg from Olsen and Sperling (1987).
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- meta | Chapter 4
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+ title | Chapter 4
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- text | A structural model for the in vivo
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+ title | A structural model for the in vivo
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  | human cornea including
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  | collagen-swelling interaction
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@@ -3154,7 +3154,7 @@ text | corneal dystrophy where the GAG concentration is found to be abn
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  | respiration (Klyce, 1981). Extension of the model to include these multiple species and
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  | their interactions through metabolic reactions for aerobic and anaerobic respiration
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  | is presented in chapter 7.
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- meta | Chapter 5
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+ title | Chapter 5
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  title | Mechanisms of self-organization for
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  | the collagen fibril arrangement in
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  text | The GAGs have an important but less-understood role in the maintenance of the
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  | lattice-like fibril arrangement. Keratan sulfate, the predominant stromal GAG com-
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  | ponent, has been shown to be involved in modulating the fibril organization by the
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- meta | 1
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- text | knockout of Chst5 in the mouse (Hayashida et al., 2006). Scott (1992) proposed
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+ | 1
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+ | knockout of Chst5 in the mouse (Hayashida et al., 2006). Scott (1992) proposed
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  | that two or more GAG chains, originating at different core proteins on neighboring
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  | fibrils, may form an antiparallel duplexed association which appears as a bridge-like
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  | structure spanning the interfibrillar distance in electron microscopy after staining,
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  | 2010; Quantock et al., 1990) or to genetically mutated corneas (Hayashida et al.,
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  | 2006), which leads to a reduction in interfibrillar distance and a more chaotic fibril
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  | organization due to the lack of PG regulation.
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- meta | Chapter 6
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+ title | Chapter 6
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  title | Fluid pressure across active
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  | biological membrane in a charged
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- text | 6.6 Application to the endothelial transport in the
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+ title | 6.6 Application to the endothelial transport in the
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  | in vivo cornea
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- | In this section, we present an example by applying equations (7.25, 6.42) to study
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+ text | In this section, we present an example by applying equations (7.25, 6.42) to study
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  | the endothelial ionic transport process of the in vivo cornea. The fluid and ion
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  | exchanges across the endothelium controls the level of corneal hydration, which is a
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  | crucial factor for the maintenance of the transparency of the tissue. Fixed charges
@@ -4549,9 +4549,9 @@ text | is negative. This view of a positive stromal fluid pressure is c
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  | underlying metabolic reactions (Schultz, 1980). This development requires identifica-
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  | tion of the molecular mechanisms, and can potentially enhance the understanding of
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  | active mechanism involvement in membrane transport.
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- meta | Chapter 7
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+ title | Chapter 7
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- text | A chemo-electro-mechanical model
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+ title | A chemo-electro-mechanical model
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  | for corneal metabolism
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  | and edema
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  |
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  text | simplification. The effect of solute diffusivity on contact-lens-induced corneal swelling
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  | will be investigated in section 7.4.3.
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+ text |
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  title | Initial displacement caused by the IOP
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  text | Fringe plot of the initial displacement, obtained by finite element solution of equa-
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  | thickness at five values of lens transmissibility for (a) DB− = 4.89 × 10−6 cm2 /s,
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  | DL− = 4.4 × 10−6 cm2 /s and (b) DB− = 1.5 × 10−6 cm2 /s, DL− = 4.4 × 10−6 cm2 /s.
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- text | 7.4.4 Biomechanical behavior after introduction of intrastro-
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+ title | 7.4.4 Biomechanical behavior after introduction of intrastro-
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  | mal inlay
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- | The use of intrastromal inlay provides an alternative treatment to improve near and
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+ text | The use of intrastromal inlay provides an alternative treatment to improve near and
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  | intermediate vision in presbyopes without the removal of tissue (Arlt et al., 2015;
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  meta | CHAPTER 7. A CHEMO-ELECTRO-MECHANICAL MODEL 142
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@@ -5895,7 +5895,7 @@ text | under extreme situations (Cheng et al., 2015; Muller et al., 200
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  | which renders the displacement and fluid pressure as time-independent. However, the
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  | theory is readily to be extended to transient cases, which may be useful for interpret-
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  | ing experimental results that are obtained in acute situations.
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- meta | Chapter 8
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+ title | Chapter 8
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  title | Conclusions and future directions
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  meta | xvii
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  | xviii
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- | Chapter 1
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  blank |
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  title | Introduction
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@@ -1568,7 +1568,7 @@ text | as free components. There is minimal energy transfer to higher f
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  | decrease. Interactions between periodic wave trains and a ridge can lead to as much
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  | as 40% of the transmitted wave energy propagating as higher harmonic waves.
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  meta | 30 CHAPTER 2. HARMONIC WAVE GENERATION
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- | Chapter 3
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+ title | Chapter 3
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  title | Wave breaking criteria1
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@@ -3099,7 +3099,7 @@ text | wave frequency, and thus the time scale associated with the wave
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  | efficiency based on the instability mechanism, further study is needed to directly
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  | measure the mixing efficiency of such breaking events.
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  meta | 72 CHAPTER 3. WAVE BREAKING CRITERIA
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- | Chapter 4
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+ title | Chapter 4
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  title | Overall event efficiency of breaking
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  | interfacial waves at a ridge1
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  | ocean from breaking internal waves, it appears a simple, constant mixing efficiency
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  | is not appropriate as the wave properties, stratification and topography can lead to
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  | spatially varying mixing conditions.
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- meta | Chapter 5
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+ title | Chapter 5
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  title | Local mixing processes in breaking
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  | interfacial waves1
@@ -5145,7 +5145,7 @@ text | Smyth et al., 2001). Others have taken the opposing view that tu
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  | Froude numbers would tend to converge.
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  |
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- title | What determines the turbulent Froude number?
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+ text | What determines the turbulent Froude number?
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  text | From figure 5.10, it appears that the turbulent Froude number is O(1) within the
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  | turbulent patch resulting from wave breaking. It is reasonable that an internal wave
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  | The overall efficiency may increase for waves breaking at a ridge in a more continuous
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  | stratification, as boundary-induced turbulent kinetic energy dissipation would lead to
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  | overturning of density gradients.
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+ title | Chapter 6
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  title | Conclusions and Future Work
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  meta | viii
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- | Dedication
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+ title | Dedication
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  text | For my Wai-Wai
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  |
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  meta | 115
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- | APPENDIX A: Supporting information for
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+ title | APPENDIX A: Supporting information for
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  | Chapter 2
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  title | A.1 Reactive Transport Modeling using MIN3P
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  meta | 124
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- | APPENDIX B: Supporting Information for
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  | Chapter 3
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  title | B.1 Reactive Transport Modeling using MIN3P
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  meta |
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    ix
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  title | List of Tables
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- title | Introduction
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+ text | Introduction
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  text | Table 1 CENP-A nomenclature in different species 60
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  meta |
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    x
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  title | List of Figures
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  blank |
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- title | Introduction
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+ text | Introduction
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  text | Figure 1 Chromatin and nucleosome structure 58
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  meta |
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    xi
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- | Chapter 2
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+ text | Chapter 2
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  blank |
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  text | Figure 1 Characterization of X. laevis M18BP1. 158
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@@ -3150,7 +3150,7 @@ text | (aa1-373); oligomerization (aa74-244); CENP-A nucleosome binding
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  text | DNA binding (aa422-537); dimerization (aa856-944); and centromere targeting
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- title | (aa426-537; aa736-758, the CENP-C motif; and aa856-944, the cupin/dimerization
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+ text | (aa426-537; aa736-758, the CENP-C motif; and aa856-944, the cupin/dimerization
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  blank |
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  text | domain) (Carroll et al., 2010; Cohen et al., 2008; Fukagawa et al., 2001a; Heeger,
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  |
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  meta |
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    60
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- text | Chapter 1
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+ title | Chapter 1
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- text | Development of an in vitro system for centromeric chromatin assembly in
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+ title | Development of an in vitro system for centromeric chromatin assembly in
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- text | Xenopus laevis egg extracts.**
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+ title | Xenopus laevis egg extracts.**
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  |
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  |
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  blank |
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  text | addition is shown to the left of each panel. Scale bar = 10µm.
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- title | C) Quantification of myc-CENP-A fluorescence intensity at centromeres for the
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+ text | C) Quantification of myc-CENP-A fluorescence intensity at centromeres for the
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  blank |
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  text | assembly reactions represented in 1B, normalized to the metaphase control sample
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  blank |
@@ -4558,7 +4558,7 @@ text | variant, H2A.X-F (top band, 19 kD). In egg extract, H2A.X-F is
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  text | chromatin with approximately equal stoichiometry to H2A. (Shechter et al., 2009).
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- title | C) Quantification of CENP-A and H2A integrated
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+ text | C) Quantification of CENP-A and H2A integrated
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  text | intensities under each condition, normalized to the levels in metaphase
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@@ -4578,7 +4578,7 @@ text | per condition. Time is in minutes. Error bars, SEM; n=3.
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  |
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  |
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- title | Figure 4. xHJURP, myc-CENP-A, and the sperm chromatin
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+ text | Figure 4. xHJURP, myc-CENP-A, and the sperm chromatin
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  text | template do not need to pass through mitosis for efficient myc-CENP-A
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@@ -4623,7 +4623,7 @@ text | Supplemental Figure Legends.
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  |
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  |
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- title | Figure S1. Characterization of xHJURP-mediated CENP-A
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+ text | Figure S1. Characterization of xHJURP-mediated CENP-A
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  text | assembly assay in Xenopus egg extract.
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  meta |
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    104
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- | Chapter 2
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+ title | Chapter 2
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- text | CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin
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+ title | CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin
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- text | assembly.**
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+ title | assembly.**
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  |
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  |
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- ref | **Some content from (Moree, B.*, Meyer, C.B.*, Fuller, C.J., and Straight, A.F. 2011.
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+ text | **Some content from (Moree, B.*, Meyer, C.B.*, Fuller, C.J., and Straight, A.F. 2011.
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  | CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly. J.
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  | Cell Biol. 194:855-871.)
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  meta |
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    111
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  title | Results
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- text | Characterization of X. laevis M18BP1.
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+ title | Characterization of X. laevis M18BP1.
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  text | In human somatic cells and C. elegans, new CENP-A assembly requires the
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@@ -6240,7 +6240,7 @@ text | immunofluorescence as described below. For CENP-A assembly assay
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  text | M18BP1-depleted extracts (Figure 3C,D), 1 µl of HJURP IVT protein was added per
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- title | 20 µl assembly reaction. For CENP-A assembly assays using CENP-C-depleted
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+ text | 20 µl assembly reaction. For CENP-A assembly assays using CENP-C-depleted
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  text | extracts, (Figure 6A,B) HJURP RNA was used instead of HJURP IVT protein.
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@@ -6307,7 +6307,7 @@ text | bound to Dynabeads protein A beads (Invitrogen). For 100 µl of
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  text | xM18BP1 antibody or 0.6 µg of α-CENP-C antibody was bound to 33 µl of beads in
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- title | 10mM Tris-HCl, pH 7.4, 150mM NaCl, and 0.1% Triton X-100 for 1h at 4°C. An
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+ text | 10mM Tris-HCl, pH 7.4, 150mM NaCl, and 0.1% Triton X-100 for 1h at 4°C. An
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  text | equivalent amount of whole rabbit IgG was used for control depletions. The beads
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@@ -6336,7 +6336,7 @@ text | of exposure to a magnet, washed four times with TBSTx buffer, an
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  text | protein sample buffer (200 mM Tris pH 6.8, 40 mM EDTA, 0.05% bromophenol blue,
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- title | 10% SDS, 50% glycerol). For immunoprecipitations of M18BP1-FLAG isoforms
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+ text | 10% SDS, 50% glycerol). For immunoprecipitations of M18BP1-FLAG isoforms
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  text | (Figure 6C,D) and myc-M18BP1 isoforms (Supplemental Figure 7A), 2 µl of
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@@ -6369,7 +6369,7 @@ text | CENP-C-depleted extract. For M18BP1 addback experiments, 0.5 µl
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  text | M18BP1-1-FLAG and M18BP1-2-FLAG IVT proteins (Figure 2C-E), or 1 µl of
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- title | M18BP1-1-FLAG or M18BP1-2-FLAG IVT protein (Supplemental Figure 3), were
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+ text | M18BP1-1-FLAG or M18BP1-2-FLAG IVT protein (Supplemental Figure 3), were
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  text | added per 20 µl of M18BP1-depleted extract. For CENP-A assembly assays using
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@@ -7580,7 +7580,7 @@ text | of centromeric chromatin containing H3 placeholder nucleosomes (
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  |
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  |
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- text | Regulating the levels of CENP-A at centromeres
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+ title | Regulating the levels of CENP-A at centromeres
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  text | The post-assembly levels of CENP-A are constant through rounds of division,
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@@ -7711,9 +7711,9 @@ text | HJURP and RSF.
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  |
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  |
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- text | Functional interactions between centromeric chromatin and pericentric
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+ title | Functional interactions between centromeric chromatin and pericentric
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- text | heterochromatin
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+ title | heterochromatin
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  text | An exciting and largely unexplored future area of research is the functional
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  meta | vi
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  title | Contents
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- title | Abstract iv
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+ text | Abstract iv
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- title | Acknowledgments v
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+ text | Acknowledgments v
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  text | 1 Introduction 1
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  | 1.1 Motivation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
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  |
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  |
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  meta | xxv
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- | Chapter 1
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+ title | Chapter 1
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  title | Introduction
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@@ -1591,7 +1591,7 @@ text | partial differential equations, their discretization, and PDE-co
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  | the number of parameters and state variables are comparable. Finally, Chapter 7 offers conclusions
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  | and ideas for future research and Appendix D introduces an adjoint method for optimization of
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  | time-dependent PDEs, possibly with periodicity constraints, discretized with high-order methods.
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- meta | Chapter 2
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+ title | Chapter 2
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  title | PDE-Constrained Optimization
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@@ -3243,7 +3243,7 @@ text | Once the dual variable for each functional has been computed, th
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  | bound on a QoI (not amenable to elimination) and the second requires time-periodicity of the PDE
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  | solution (amenable to elimination). Nonlinear elimination is applied to the periodicity constraint
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  | and the adjoint equations are modified accordingly.
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- meta | Chapter 3
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+ title | Chapter 3
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  title | Generalized Multifidelity Trust
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  | Region Method
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  text | µj+1
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  | k = µjk + αpjk
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  blank |
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- title | 5: BFGS update: Define sjk and ykj as
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+ text | 5: BFGS update: Define sjk and ykj as
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  blank |
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  text | sjk = µj+1
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  | k − µjk ykj = ∇φγk (µj+1 γ j
@@ -4744,7 +4744,7 @@ text | 2.0000e+00 2.0002e+00 2.0000e+00 2.000
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  | 2.0000e+00 2.0000e+00 2.0000e+00 2.0000e+00 5.5167e-05 3.0124e-01 1.3148e-05 True
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  | 2.0000e+00 2.0000e+00 2.0000e+00 2.0000e+00 8.5278e-05 6.9467e+00 2.6296e-05 True
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  meta | 76
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- | Chapter 4
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+ title | Chapter 4
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  title | Projection-Based Model Reduction
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@@ -6162,8 +6162,8 @@ text | where all terms are evaluated at the linearization point. A vari
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  | terpolation requires a sufficiently large mask such that P T r(u, µ) = 0 =⇒ r(u, µ) = 0. These
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  | results are stated and proved in Proposition 4.7.
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- meta | Proposition 4.7. Let (Φ∂ , Θ∂ , P ) define a masked minimum-residual sensitivity reduced-order
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- | CHAPTER 4. PROJECTION-BASED MODEL REDUCTION 102
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+ text | Proposition 4.7. Let (Φ∂ , Θ∂ , P ) define a masked minimum-residual sensitivity reduced-order
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+ meta | CHAPTER 4. PROJECTION-BASED MODEL REDUCTION 102
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  |
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  |
@@ -6631,8 +6631,8 @@ text | U , Σ, V = ProbSVD(X, k
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  | 2: Form Y = (AAT )q AΩ
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  | 3: Compute QR factorization of Y: Y = QR
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  | 4: Form B = QT A
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- meta | 5: Compute SVD of B = ŨΣVT
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- title | 6: Set U = QŨ
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+ | 5: Compute SVD of B = ŨΣVT
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+ | 6: Set U = QŨ
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  |
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  text | This completes the discussion of the algorithms that will prove useful in defining the trial basis
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  text | Φ∂ = Φ Φλ = Ψ, (4.147)
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- meta | the minimum-residual sensitivity and adjoint reduced-order models for the LSPG projection follow
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- | CHAPTER 4. PROJECTION-BASED MODEL REDUCTION 115
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+ text | the minimum-residual sensitivity and adjoint reduced-order models for the LSPG projection follow
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+ meta | CHAPTER 4. PROJECTION-BASED MODEL REDUCTION 115
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  |
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  | and interpolation that only holds under stricter assumptions on solutions of the discrete PDE. In this
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  | work, the mask P is constructed solely from the primal reduced-order basis Φ and problem-specific
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  | information following the approach in [198].
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+ title | Chapter 5
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  title | Optimization via Model Reduction
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  | and Residual-Based Trust Regions
@@ -8375,8 +8375,8 @@ text | Figure 5.5: Convergence history of various optimization solvers
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  | ( ), adj-etr-intpt ( ), adj-ctr-intpt ( ), adj-ctr-stcg ( ).
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  |
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- title | [52, 210].
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- text | The increased convergence rate, in terms of major iterations (and therefore HDM evaluations),
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+ text | [52, 210].
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+ | The increased convergence rate, in terms of major iterations (and therefore HDM evaluations),
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  | of Algorithms 11 and 12 comes at the price of a large number of ROM evaluations. Figure 5.7 shows
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  | the cumulative number of primal ROM queries as a function of major iteration and a histogram
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  | of the number of primal ROM evaluations at a given reduced basis size (ku ). The methods that
@@ -9664,7 +9664,7 @@ text | HDM-based ROM-b
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  | µ∗ − µRAE2822
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  | 2.28 × 10−3 % 4.17 × 10−6 %
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  | kµRAE2822 k
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  title | Model Reduction and Sparse Grids
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  | for Efficient Stochastic
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  |
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  |
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  title | 6.3 Multifidelity Trust Region Method Based on Two-Level
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- text | Approximation
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- | This section presents the primary contribution of this chapter: the use of sparse grids and model
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+ | Approximation
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+ text | This section presents the primary contribution of this chapter: the use of sparse grids and model
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  | reduction in the multifidelity trust region framework of Chapter 3 to yield an efficient algorithm for
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  | stochastic PDE-constrained optimization. The approximation model, mk (µ), that is central to the
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  | trust region theory will be taken as the two-level approximation of risk-averse measures of quantities
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  |
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  |
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  title | 6.4 Numerical Experiment: Optimal Control of the Viscous
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- text | Burgers’ Equation with Uncertain Coefficients
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- | This section studies the performance of the proposed algorithms (Algorithms 15 and 16) on a simple
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+ | Burgers’ Equation with Uncertain Coefficients
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+ text | This section studies the performance of the proposed algorithms (Algorithms 15 and 16) on a simple
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  | stochastic PDE-constrained optimization problem: optimal control of the one-dimensional viscous
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  | Burgers’ equation with uncertain coefficients. This is precisely the stochastic counterpart to the
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  | problem in Section 5.5.2 used to study the deterministic trust region algorithm based on reduced-
@@ -11458,7 +11458,7 @@ text | F (µk ) mk (µk ) F (µ̂k ) mk (µ̂k
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  | 5.0405e-02 5.0404e-02 5.0403e-02 5.0401e-02 8.3139e-05 9.9946e-01 1.6000e+03 1.0000e+00
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  | 5.0403e-02 5.0401e-02 - - 2.2846e-06 - - -
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  meta | CHAPTER 6. STOCHASTIC PDE OPTIMIZATION WITH ROMS AND SPARSE GRIDS 204
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- | Chapter 7
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+ title | Chapter 7
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  title | Conclusions
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@@ -11577,7 +11577,7 @@ text | • Possible improvements to the proposed methods. A number o
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  | adjoint residual). Another possible enhancement that would have a positive and widespread
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  | impact across the methods proposed in this thesis is the use of improved, faster, and possibly
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  | probabilistic, [15] error indicators. In the trust region framework, these can either be used as
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  | which will be combined in Section C.2 to develop the nested optimization algorithm.
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  |
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- text | C.1.1 Outer Layer of Reduction: Restriction of Parameter Space
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- | The PDE-constrained optimization problem that motivates this work takes the form (reduced-space
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+ title | C.1.1 Outer Layer of Reduction: Restriction of Parameter Space
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+ text | The PDE-constrained optimization problem that motivates this work takes the form (reduced-space
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  | formulation)
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  | minimize F (µ) := f (u(µ), µ) (C.1)
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  | µ∈RNµ
@@ -12639,8 +12639,8 @@ text | Thus, the adjoint computation requires the solution of one linea
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  | transpose of the Jacobian matrix, regardless of kµ .
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  |
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- text | C.1.2 Inner Layer of Reduction: Projection-Based Model Reduction
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- | While the first layer of reduction reduces the number of optimization variables, the large cost as-
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+ title | C.1.2 Inner Layer of Reduction: Projection-Based Model Reduction
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+ text | While the first layer of reduction reduces the number of optimization variables, the large cost as-
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  | sociated with solving the PDE for any µ ∈ A(µ̄, Υ) remains since the dimensionality of the state
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  | space, i.e., number of equations and unknowns, is Nu  1. The second layer of reduction aims
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  | to address this source computational expense through the application of projection-based model
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  title | C.2.2 Inner Iteration: Multifidelity Optimization with Reduced-Order
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- text | Models
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- | Each iteration of the affine parameter space adaptation requires the solution of the PDE-constrained
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+ | Models
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+ text | Each iteration of the affine parameter space adaptation requires the solution of the PDE-constrained
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  | optimization problem (C.24), which can be written as an optimization problem in few variables
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  | (kµ  Nµ ). Even though the optimization problem contains few variables, it is still expensive
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  | to solve since each objective evaluation requires the solution of a potentially large-scale partial
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  text | (n) (n) (n) (n) (n)
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  | Ri (u(n−1) , k1 , . . . , ki , µ) = M ki − ∆tn r ui , µ, tn−1 + ci ∆tn = 0
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- meta | for n = 1, . . . , n and i = 1, . . . , s. Differentiation of these expressions with respect to µ gives rise to
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- | APPENDIX D. UNSTEADY, PERIODIC PDE-CONSTRAINED OPTIMIZATION 246
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+ text | for n = 1, . . . , n and i = 1, . . . , s. Differentiation of these expressions with respect to µ gives rise to
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+ meta | APPENDIX D. UNSTEADY, PERIODIC PDE-CONSTRAINED OPTIMIZATION 246
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  title | D.4.3 Generalized Reduced-Gradient Method for PDE Optimization with
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- text | Time-Periodicity Constraints
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- | Consider the fully discrete time-dependent PDE-constrained optimization problem
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+ | Time-Periodicity Constraints
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+ text | Consider the fully discrete time-dependent PDE-constrained optimization problem
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  text | (1)
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  | minimize F (u(0) , . . . , u(Nt ) , k1 , . . . , ks(Nt ) , µ)