tooluniverse 1.0.10__tar.gz → 1.0.11__tar.gz
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- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/PKG-INFO +3 -2
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/pyproject.toml +4 -3
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/__init__.py +57 -1
- tooluniverse-1.0.11/src/tooluniverse/blast_tool.py +132 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/boltz_tool.py +2 -2
- tooluniverse-1.0.11/src/tooluniverse/cbioportal_tool.py +42 -0
- tooluniverse-1.0.11/src/tooluniverse/clinvar_tool.py +284 -0
- tooluniverse-1.0.11/src/tooluniverse/compose_scripts/tool_discover.py +2203 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/agentic_tools.json +0 -370
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/alphafold_tools.json +6 -6
- tooluniverse-1.0.11/src/tooluniverse/data/blast_tools.json +112 -0
- tooluniverse-1.0.11/src/tooluniverse/data/cbioportal_tools.json +87 -0
- tooluniverse-1.0.11/src/tooluniverse/data/clinvar_tools.json +235 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/compose_tools.json +0 -89
- tooluniverse-1.0.11/src/tooluniverse/data/dbsnp_tools.json +275 -0
- tooluniverse-1.0.11/src/tooluniverse/data/emdb_tools.json +61 -0
- tooluniverse-1.0.11/src/tooluniverse/data/ensembl_tools.json +259 -0
- tooluniverse-1.0.11/src/tooluniverse/data/file_download_tools.json +275 -0
- tooluniverse-1.0.11/src/tooluniverse/data/geo_tools.json +238 -0
- tooluniverse-1.0.11/src/tooluniverse/data/gnomad_tools.json +109 -0
- tooluniverse-1.0.11/src/tooluniverse/data/gtopdb_tools.json +68 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/gwas_tools.json +32 -0
- tooluniverse-1.0.11/src/tooluniverse/data/interpro_tools.json +199 -0
- tooluniverse-1.0.11/src/tooluniverse/data/jaspar_tools.json +70 -0
- tooluniverse-1.0.11/src/tooluniverse/data/kegg_tools.json +356 -0
- tooluniverse-1.0.11/src/tooluniverse/data/mpd_tools.json +87 -0
- tooluniverse-1.0.11/src/tooluniverse/data/ols_tools.json +314 -0
- tooluniverse-1.0.11/src/tooluniverse/data/package_discovery_tools.json +64 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/packages/categorized_tools.txt +0 -1
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/packages/machine_learning_tools.json +0 -47
- tooluniverse-1.0.11/src/tooluniverse/data/paleobiology_tools.json +91 -0
- tooluniverse-1.0.11/src/tooluniverse/data/pride_tools.json +62 -0
- tooluniverse-1.0.11/src/tooluniverse/data/pypi_package_inspector_tools.json +158 -0
- tooluniverse-1.0.11/src/tooluniverse/data/python_executor_tools.json +341 -0
- tooluniverse-1.0.11/src/tooluniverse/data/regulomedb_tools.json +50 -0
- tooluniverse-1.0.11/src/tooluniverse/data/remap_tools.json +89 -0
- tooluniverse-1.0.11/src/tooluniverse/data/screen_tools.json +89 -0
- tooluniverse-1.0.11/src/tooluniverse/data/tool_discovery_agents.json +428 -0
- tooluniverse-1.0.11/src/tooluniverse/data/tool_discovery_agents.json.backup +1343 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/uniprot_tools.json +77 -0
- tooluniverse-1.0.11/src/tooluniverse/data/web_search_tools.json +250 -0
- tooluniverse-1.0.11/src/tooluniverse/data/worms_tools.json +55 -0
- tooluniverse-1.0.11/src/tooluniverse/dbsnp_tool.py +209 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/default_config.py +35 -2
- tooluniverse-1.0.11/src/tooluniverse/emdb_tool.py +30 -0
- tooluniverse-1.0.11/src/tooluniverse/ensembl_tool.py +154 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/execute_function.py +74 -14
- tooluniverse-1.0.11/src/tooluniverse/file_download_tool.py +269 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/geo_tool.py +81 -28
- tooluniverse-1.0.11/src/tooluniverse/gnomad_tool.py +111 -0
- tooluniverse-1.0.11/src/tooluniverse/gtopdb_tool.py +41 -0
- tooluniverse-1.0.11/src/tooluniverse/interpro_tool.py +72 -0
- tooluniverse-1.0.11/src/tooluniverse/jaspar_tool.py +30 -0
- tooluniverse-1.0.11/src/tooluniverse/kegg_tool.py +230 -0
- tooluniverse-1.0.11/src/tooluniverse/mpd_tool.py +42 -0
- tooluniverse-1.0.11/src/tooluniverse/ncbi_eutils_tool.py +96 -0
- tooluniverse-1.0.11/src/tooluniverse/ols_tool.py +435 -0
- tooluniverse-1.0.11/src/tooluniverse/package_discovery_tool.py +217 -0
- tooluniverse-1.0.11/src/tooluniverse/paleobiology_tool.py +30 -0
- tooluniverse-1.0.11/src/tooluniverse/pride_tool.py +30 -0
- tooluniverse-1.0.11/src/tooluniverse/pypi_package_inspector_tool.py +593 -0
- tooluniverse-1.0.11/src/tooluniverse/python_executor_tool.py +711 -0
- tooluniverse-1.0.11/src/tooluniverse/regulomedb_tool.py +30 -0
- tooluniverse-1.0.11/src/tooluniverse/remap_tool.py +44 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/remote/depmap_24q2/depmap_24q2_mcp_tool.py +1 -1
- tooluniverse-1.0.11/src/tooluniverse/screen_tool.py +44 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/smcp_server.py +3 -3
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tool_finder_embedding.py +3 -1
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tool_finder_keyword.py +3 -1
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tool_finder_llm.py +6 -2
- tooluniverse-1.0.11/src/tooluniverse/tools/BLAST_nucleotide_search.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/BLAST_protein_search.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ClinVar_search_variants.py +63 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/CodeQualityAnalyzer.py +3 -3
- tooluniverse-1.0.11/src/tooluniverse/tools/EMDB_get_structure.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/GtoPdb_get_targets.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/InterPro_get_domain_details.py +46 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/ClinVar_search_variants.py → tooluniverse-1.0.11/src/tooluniverse/tools/InterPro_get_protein_domains.py +10 -13
- tooluniverse-1.0.11/src/tooluniverse/tools/InterPro_search_domains.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/JASPAR_get_transcription_factors.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/MPD_get_phenotype_data.py +59 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/PRIDE_search_proteomics.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/PackageAnalyzer.py +55 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/Paleobiology_get_fossils.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/PyPIPackageInspector.py +59 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ReMap_get_transcription_factor_binding.py +59 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ReferenceInfoAnalyzer.py +55 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/dbSNP_get_variant_by_rsid.py → tooluniverse-1.0.11/src/tooluniverse/tools/RegulomeDB_query_variant.py +7 -7
- tooluniverse-1.0.11/src/tooluniverse/tools/SCREEN_get_regulatory_elements.py +59 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/ArgumentDescriptionOptimizer.py → tooluniverse-1.0.11/src/tooluniverse/tools/TestResultsAnalyzer.py +13 -13
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/ToolDiscover.py +11 -11
- tooluniverse-1.0.11/src/tooluniverse/tools/UniProt_id_mapping.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/UniProt_search.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/UnifiedToolGenerator.py +59 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/WoRMS_search_species.py +49 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/XMLToolOptimizer.py +55 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/__init__.py +119 -29
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/alphafold_get_annotations.py +3 -3
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/alphafold_get_prediction.py +3 -3
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/tools/alphafold_get_summary.py +3 -3
- tooluniverse-1.0.11/src/tooluniverse/tools/cBioPortal_get_cancer_studies.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/cBioPortal_get_mutations.py +52 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/gnomAD_query_variant.py → tooluniverse-1.0.11/src/tooluniverse/tools/clinvar_get_clinical_significance.py +8 -11
- tooluniverse-1.0.11/src/tooluniverse/tools/clinvar_get_variant_details.py +49 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/dbSNP_get_variant_by_rsid.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/dbsnp_get_frequencies.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/dbsnp_search_by_gene.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/download_binary_file.py +66 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/download_file.py +71 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/download_text_content.py +55 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/dynamic_package_discovery.py +59 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ensembl_get_sequence.py +52 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/Ensembl_lookup_gene_by_symbol.py → tooluniverse-1.0.11/src/tooluniverse/tools/ensembl_get_variants.py +11 -11
- tooluniverse-1.0.11/src/tooluniverse/tools/ensembl_lookup_gene.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/geo_get_dataset_info.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/geo_get_sample_info.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/geo_search_datasets.py +67 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/gnomad_get_gene_constraints.py +49 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/kegg_find_genes.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/kegg_get_gene_info.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/kegg_get_pathway_info.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/kegg_list_organisms.py +44 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/kegg_search_pathway.py +46 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_find_similar_terms.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_get_ontology_info.py +52 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_get_term_ancestors.py +67 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_get_term_children.py +67 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_get_term_info.py +49 -0
- tooluniverse-1.0.10/src/tooluniverse/tools/CodeOptimizer.py → tooluniverse-1.0.11/src/tooluniverse/tools/ols_search_ontologies.py +22 -14
- tooluniverse-1.0.11/src/tooluniverse/tools/ols_search_terms.py +71 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/python_code_executor.py +79 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/python_script_runner.py +79 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/web_api_documentation_search.py +63 -0
- tooluniverse-1.0.11/src/tooluniverse/tools/web_search.py +71 -0
- tooluniverse-1.0.11/src/tooluniverse/uniprot_tool.py +358 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/url_tool.py +18 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/utils.py +2 -2
- tooluniverse-1.0.11/src/tooluniverse/web_search_tool.py +229 -0
- tooluniverse-1.0.11/src/tooluniverse/worms_tool.py +64 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse.egg-info/PKG-INFO +3 -2
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse.egg-info/SOURCES.txt +103 -14
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse.egg-info/requires.txt +2 -1
- tooluniverse-1.0.10/src/tooluniverse/clinvar_tool.py +0 -90
- tooluniverse-1.0.10/src/tooluniverse/compose_scripts/tool_discover.py +0 -705
- tooluniverse-1.0.10/src/tooluniverse/data/genomics_tools.json +0 -174
- tooluniverse-1.0.10/src/tooluniverse/data/geo_tools.json +0 -86
- tooluniverse-1.0.10/src/tooluniverse/dbsnp_tool.py +0 -71
- tooluniverse-1.0.10/src/tooluniverse/ensembl_tool.py +0 -61
- tooluniverse-1.0.10/src/tooluniverse/gnomad_tool.py +0 -63
- tooluniverse-1.0.10/src/tooluniverse/tools/TestCaseGenerator.py +0 -46
- tooluniverse-1.0.10/src/tooluniverse/tools/ToolDescriptionOptimizer.py +0 -67
- tooluniverse-1.0.10/src/tooluniverse/tools/ToolImplementationGenerator.py +0 -67
- tooluniverse-1.0.10/src/tooluniverse/tools/ToolOptimizer.py +0 -59
- tooluniverse-1.0.10/src/tooluniverse/tools/ToolSpecificationGenerator.py +0 -67
- tooluniverse-1.0.10/src/tooluniverse/tools/ToolSpecificationOptimizer.py +0 -63
- tooluniverse-1.0.10/src/tooluniverse/tools/UCSC_get_genes_by_region.py +0 -67
- tooluniverse-1.0.10/src/tooluniverse/tools/get_hyperopt_info.py +0 -49
- tooluniverse-1.0.10/src/tooluniverse/ucsc_tool.py +0 -60
- tooluniverse-1.0.10/src/tooluniverse/uniprot_tool.py +0 -155
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/LICENSE +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/README.md +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/setup.cfg +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/admetai_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/agentic_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/alphafold_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/arxiv_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/base_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/biogrid_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/biorxiv_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/build_optimizer.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/cache/__init__.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/cache/memory_cache.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/cache/result_cache_manager.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/cache/sqlite_backend.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/cellosaurus_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/chem_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/__init__.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/biomarker_discovery.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/comprehensive_drug_discovery.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/drug_safety_analyzer.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/enhanced_multi_agent_literature_search.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/literature_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/multi_agent_literature_search.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/output_summarizer.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/tool_description_optimizer.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/tool_graph_composer.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/tool_graph_generation.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_scripts/tool_metadata_generator.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/compose_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/core_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/crossref_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/ctg_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/custom_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/dailymed_tool.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/__init__.py +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/admetai_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/adverse_event_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/arxiv_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/biorxiv_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/boltz_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/cellosaurus_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/chembl_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/clinicaltrials_gov_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/core_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/crossref_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/dailymed_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/dataset_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/dblp_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/disease_target_score_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/doaj_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/drug_discovery_agents.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/efo_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/embedding_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/enrichr_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/europe_pmc_tools.json +0 -0
- {tooluniverse-1.0.10 → tooluniverse-1.0.11}/src/tooluniverse/data/expert_feedback_tools.json +0 -0
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PythonScriptRunner,
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WebSearchTool,
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WebAPIDocumentationSearchTool,
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CellosaurusQueryConverterTool,
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ClinVarGetVariantDetails,
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ClinVarGetClinicalSignificance,
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# Literature search tools
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ChEMBLTool = _LazyImportProxy("chem_tool", "ChEMBLTool")
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PythonCodeExecutor = _LazyImportProxy("python_executor_tool", "PythonCodeExecutor")
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OLSTool = _LazyImportProxy("ols_tool", "OLSTool")
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PMCTool = _LazyImportProxy("pmc_tool", "PMCTool")
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WebSearchTool = _LazyImportProxy("web_search_tool", "WebSearchTool")
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WebAPIDocumentationSearchTool = _LazyImportProxy(
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"web_search_tool", "WebAPIDocumentationSearchTool"
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)
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DynamicPackageDiscovery = _LazyImportProxy(
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"package_discovery_tool", "DynamicPackageDiscovery"
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)
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PyPIPackageInspector = _LazyImportProxy(
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"pypi_package_inspector_tool", "PyPIPackageInspector"
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)
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__all__ = [
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"__version__",
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@@ -456,6 +503,7 @@ __all__ = [
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"CellosaurusSearchTool",
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|
"CellosaurusQueryConverterTool",
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|
"CellosaurusGetCellLineInfoTool",
|
|
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|
+
"OLSTool",
|
|
459
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|
# Literature search tools
|
|
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|
"ArXivTool",
|
|
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|
"CrossrefTool",
|
|
@@ -469,4 +517,12 @@ __all__ = [
|
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"CoreTool",
|
|
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|
"PMCTool",
|
|
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|
"ZenodoTool",
|
|
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|
+
"WebSearchTool",
|
|
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|
+
"WebAPIDocumentationSearchTool",
|
|
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|
+
"DynamicPackageDiscovery",
|
|
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|
+
"PyPIPackageInspector",
|
|
524
|
+
# ClinVar tools
|
|
525
|
+
"ClinVarSearchVariants",
|
|
526
|
+
"ClinVarGetVariantDetails",
|
|
527
|
+
"ClinVarGetClinicalSignificance",
|
|
472
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|
]
|
|
@@ -0,0 +1,132 @@
|
|
|
1
|
+
from typing import Any, Dict
|
|
2
|
+
from Bio.Blast import NCBIWWW, NCBIXML
|
|
3
|
+
from Bio.Seq import Seq
|
|
4
|
+
from .base_tool import BaseTool
|
|
5
|
+
from .tool_registry import register_tool
|
|
6
|
+
|
|
7
|
+
|
|
8
|
+
@register_tool("NCBIBlastTool")
|
|
9
|
+
class NCBIBlastTool(BaseTool):
|
|
10
|
+
def __init__(self, tool_config: Dict):
|
|
11
|
+
super().__init__(tool_config)
|
|
12
|
+
self.timeout = 300 # BLAST can take a long time
|
|
13
|
+
self.max_wait_time = 600 # Maximum wait time for results
|
|
14
|
+
|
|
15
|
+
def _parse_blast_results(self, blast_xml: str) -> Dict[str, Any]:
|
|
16
|
+
"""Parse BLAST XML results into structured data"""
|
|
17
|
+
try:
|
|
18
|
+
from io import StringIO
|
|
19
|
+
|
|
20
|
+
blast_record = NCBIXML.read(StringIO(blast_xml))
|
|
21
|
+
|
|
22
|
+
results = {
|
|
23
|
+
"query_id": blast_record.query_id,
|
|
24
|
+
"query_length": blast_record.query_length,
|
|
25
|
+
"database": blast_record.database,
|
|
26
|
+
"algorithm": blast_record.application,
|
|
27
|
+
"alignments": [],
|
|
28
|
+
}
|
|
29
|
+
|
|
30
|
+
for alignment in blast_record.alignments:
|
|
31
|
+
alignment_data = {
|
|
32
|
+
"hit_id": getattr(alignment, "hit_id", "unknown"),
|
|
33
|
+
"hit_def": getattr(alignment, "hit_def", "unknown"),
|
|
34
|
+
"hit_length": getattr(alignment, "hit_length", 0),
|
|
35
|
+
"hsps": [],
|
|
36
|
+
}
|
|
37
|
+
|
|
38
|
+
for hsp in alignment.hsps:
|
|
39
|
+
hsp_data = {
|
|
40
|
+
"score": getattr(hsp, "score", 0),
|
|
41
|
+
"bits": getattr(hsp, "bits", 0),
|
|
42
|
+
"expect": getattr(hsp, "expect", 0),
|
|
43
|
+
"identities": getattr(hsp, "identities", 0),
|
|
44
|
+
"positives": getattr(hsp, "positives", 0),
|
|
45
|
+
"gaps": getattr(hsp, "gaps", 0),
|
|
46
|
+
"align_length": getattr(hsp, "align_length", 0),
|
|
47
|
+
"query_start": getattr(hsp, "query_start", 0),
|
|
48
|
+
"query_end": getattr(hsp, "query_end", 0),
|
|
49
|
+
"hit_start": getattr(hsp, "hit_start", 0),
|
|
50
|
+
"hit_end": getattr(hsp, "hit_end", 0),
|
|
51
|
+
"query": getattr(hsp, "query", ""),
|
|
52
|
+
"match": getattr(hsp, "match", ""),
|
|
53
|
+
"sbjct": getattr(hsp, "sbjct", ""),
|
|
54
|
+
}
|
|
55
|
+
alignment_data["hsps"].append(hsp_data)
|
|
56
|
+
|
|
57
|
+
results["alignments"].append(alignment_data)
|
|
58
|
+
|
|
59
|
+
return results
|
|
60
|
+
|
|
61
|
+
except Exception as e:
|
|
62
|
+
return {
|
|
63
|
+
"error": f"Failed to parse BLAST results: {str(e)}",
|
|
64
|
+
"raw_xml": (
|
|
65
|
+
blast_xml[:1000] + "..." if len(blast_xml) > 1000 else blast_xml
|
|
66
|
+
),
|
|
67
|
+
}
|
|
68
|
+
|
|
69
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
70
|
+
"""Execute BLAST search using NCBI Web service"""
|
|
71
|
+
try:
|
|
72
|
+
sequence = arguments.get("sequence", "")
|
|
73
|
+
blast_type = arguments.get("blast_type", "blastn")
|
|
74
|
+
database = arguments.get("database", "nt")
|
|
75
|
+
expect = arguments.get("expect", 10.0)
|
|
76
|
+
hitlist_size = arguments.get("hitlist_size", 50)
|
|
77
|
+
|
|
78
|
+
if not sequence:
|
|
79
|
+
return {
|
|
80
|
+
"status": "error",
|
|
81
|
+
"error": "Missing required parameter: sequence",
|
|
82
|
+
}
|
|
83
|
+
|
|
84
|
+
# Validate sequence
|
|
85
|
+
try:
|
|
86
|
+
seq_obj = Seq(sequence)
|
|
87
|
+
if len(seq_obj) < 10:
|
|
88
|
+
return {
|
|
89
|
+
"status": "error",
|
|
90
|
+
"error": "Sequence too short (minimum 10 nucleotides)",
|
|
91
|
+
}
|
|
92
|
+
except Exception as e:
|
|
93
|
+
return {
|
|
94
|
+
"status": "error",
|
|
95
|
+
"error": f"Invalid sequence format: {str(e)}",
|
|
96
|
+
}
|
|
97
|
+
|
|
98
|
+
# Perform BLAST search
|
|
99
|
+
result_handle = NCBIWWW.qblast(
|
|
100
|
+
blast_type,
|
|
101
|
+
database,
|
|
102
|
+
sequence,
|
|
103
|
+
expect=expect,
|
|
104
|
+
hitlist_size=hitlist_size,
|
|
105
|
+
format_type="XML",
|
|
106
|
+
)
|
|
107
|
+
|
|
108
|
+
# Read results
|
|
109
|
+
blast_xml = result_handle.read()
|
|
110
|
+
result_handle.close()
|
|
111
|
+
|
|
112
|
+
# Parse results
|
|
113
|
+
parsed_results = self._parse_blast_results(blast_xml)
|
|
114
|
+
|
|
115
|
+
if "error" in parsed_results:
|
|
116
|
+
return {
|
|
117
|
+
"status": "error",
|
|
118
|
+
"error": parsed_results["error"],
|
|
119
|
+
"raw_data": parsed_results.get("raw_xml", ""),
|
|
120
|
+
}
|
|
121
|
+
|
|
122
|
+
return {
|
|
123
|
+
"status": "success",
|
|
124
|
+
"data": parsed_results,
|
|
125
|
+
"query_sequence": sequence,
|
|
126
|
+
"blast_type": blast_type,
|
|
127
|
+
"database": database,
|
|
128
|
+
"hit_count": len(parsed_results["alignments"]),
|
|
129
|
+
}
|
|
130
|
+
|
|
131
|
+
except Exception as e:
|
|
132
|
+
return {"status": "error", "error": f"BLAST search failed: {str(e)}"}
|
|
@@ -170,7 +170,7 @@ class Boltz2DockingTool(BaseTool):
|
|
|
170
170
|
prediction_folder, f"{input_filename}_model_0.cif"
|
|
171
171
|
)
|
|
172
172
|
if os.path.exists(structure_file):
|
|
173
|
-
with open(structure_file, "r") as f:
|
|
173
|
+
with open(structure_file, "r", encoding="utf-8") as f:
|
|
174
174
|
results["predicted_structure"] = f.read()
|
|
175
175
|
results["structure_format"] = "cif"
|
|
176
176
|
else:
|
|
@@ -183,7 +183,7 @@ class Boltz2DockingTool(BaseTool):
|
|
|
183
183
|
prediction_folder, f"affinity_{input_filename}.json"
|
|
184
184
|
)
|
|
185
185
|
if os.path.exists(affinity_file):
|
|
186
|
-
with open(affinity_file, "r") as f:
|
|
186
|
+
with open(affinity_file, "r", encoding="utf-8") as f:
|
|
187
187
|
results["affinity_prediction"] = json.load(f)
|
|
188
188
|
else:
|
|
189
189
|
results["affinity_error"] = f"Missing {os.path.basename(affinity_file)}"
|
|
@@ -0,0 +1,42 @@
|
|
|
1
|
+
import requests
|
|
2
|
+
from typing import Any, Dict
|
|
3
|
+
from .base_tool import BaseTool
|
|
4
|
+
from .tool_registry import register_tool
|
|
5
|
+
|
|
6
|
+
|
|
7
|
+
@register_tool("CBioPortalRESTTool")
|
|
8
|
+
class CBioPortalRESTTool(BaseTool):
|
|
9
|
+
def __init__(self, tool_config: Dict):
|
|
10
|
+
super().__init__(tool_config)
|
|
11
|
+
self.base_url = "https://www.cbioportal.org/api"
|
|
12
|
+
self.session = requests.Session()
|
|
13
|
+
self.session.headers.update(
|
|
14
|
+
{"Accept": "application/json", "User-Agent": "ToolUniverse/1.0"}
|
|
15
|
+
)
|
|
16
|
+
self.timeout = 30
|
|
17
|
+
|
|
18
|
+
def _build_url(self, args: Dict[str, Any]) -> str:
|
|
19
|
+
url = self.tool_config["fields"]["endpoint"]
|
|
20
|
+
for k, v in args.items():
|
|
21
|
+
url = url.replace(f"{{{k}}}", str(v))
|
|
22
|
+
return url
|
|
23
|
+
|
|
24
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
25
|
+
try:
|
|
26
|
+
url = self._build_url(arguments)
|
|
27
|
+
response = self.session.get(url, timeout=self.timeout)
|
|
28
|
+
response.raise_for_status()
|
|
29
|
+
data = response.json()
|
|
30
|
+
|
|
31
|
+
return {
|
|
32
|
+
"status": "success",
|
|
33
|
+
"data": data,
|
|
34
|
+
"url": url,
|
|
35
|
+
"count": len(data) if isinstance(data, list) else 1,
|
|
36
|
+
}
|
|
37
|
+
except Exception as e:
|
|
38
|
+
return {
|
|
39
|
+
"status": "error",
|
|
40
|
+
"error": f"cBioPortal API error: {str(e)}",
|
|
41
|
+
"url": url,
|
|
42
|
+
}
|
|
@@ -0,0 +1,284 @@
|
|
|
1
|
+
"""
|
|
2
|
+
ClinVar REST API Tool
|
|
3
|
+
|
|
4
|
+
This tool provides access to the ClinVar database for clinical variant information,
|
|
5
|
+
disease associations, and clinical significance data.
|
|
6
|
+
"""
|
|
7
|
+
|
|
8
|
+
import requests
|
|
9
|
+
import time
|
|
10
|
+
from typing import Dict, Any, Optional
|
|
11
|
+
from .base_tool import BaseTool
|
|
12
|
+
from .tool_registry import register_tool
|
|
13
|
+
|
|
14
|
+
|
|
15
|
+
class ClinVarRESTTool(BaseTool):
|
|
16
|
+
"""Base class for ClinVar REST API tools."""
|
|
17
|
+
|
|
18
|
+
def __init__(self, tool_config):
|
|
19
|
+
super().__init__(tool_config)
|
|
20
|
+
self.base_url = "https://eutils.ncbi.nlm.nih.gov/entrez/eutils"
|
|
21
|
+
self.session = requests.Session()
|
|
22
|
+
self.session.headers.update(
|
|
23
|
+
{"Accept": "application/json", "User-Agent": "ToolUniverse/1.0"}
|
|
24
|
+
)
|
|
25
|
+
self.timeout = 30
|
|
26
|
+
|
|
27
|
+
def _make_request(
|
|
28
|
+
self, endpoint: str, params: Optional[Dict] = None, max_retries: int = 3
|
|
29
|
+
) -> Dict[str, Any]:
|
|
30
|
+
"""Make a request to the ClinVar API with automatic retry for rate limiting."""
|
|
31
|
+
url = f"{self.base_url}{endpoint}"
|
|
32
|
+
|
|
33
|
+
for attempt in range(max_retries + 1):
|
|
34
|
+
try:
|
|
35
|
+
response = self.session.get(url, params=params, timeout=self.timeout)
|
|
36
|
+
|
|
37
|
+
# Handle rate limiting (429 error)
|
|
38
|
+
if response.status_code == 429:
|
|
39
|
+
retry_after = response.headers.get("Retry-After")
|
|
40
|
+
if retry_after:
|
|
41
|
+
wait_time = int(retry_after)
|
|
42
|
+
else:
|
|
43
|
+
# Default exponential backoff: 1, 2, 4 seconds
|
|
44
|
+
wait_time = 2**attempt
|
|
45
|
+
|
|
46
|
+
if attempt < max_retries:
|
|
47
|
+
print(
|
|
48
|
+
f"Rate limited (429). Waiting {wait_time} seconds before retry {attempt + 1}/{max_retries}..."
|
|
49
|
+
)
|
|
50
|
+
time.sleep(wait_time)
|
|
51
|
+
continue
|
|
52
|
+
else:
|
|
53
|
+
return {
|
|
54
|
+
"status": "error",
|
|
55
|
+
"error": f"Rate limited after {max_retries} retries. Please wait before making more requests.",
|
|
56
|
+
"url": url,
|
|
57
|
+
"retry_after": retry_after,
|
|
58
|
+
}
|
|
59
|
+
|
|
60
|
+
response.raise_for_status()
|
|
61
|
+
|
|
62
|
+
# ClinVar API returns XML by default, but we can request JSON
|
|
63
|
+
if params and params.get("retmode") == "json":
|
|
64
|
+
data = response.json()
|
|
65
|
+
else:
|
|
66
|
+
# Parse XML response
|
|
67
|
+
data = response.text
|
|
68
|
+
|
|
69
|
+
return {
|
|
70
|
+
"status": "success",
|
|
71
|
+
"data": data,
|
|
72
|
+
"url": url,
|
|
73
|
+
"content_type": response.headers.get(
|
|
74
|
+
"content-type", "application/xml"
|
|
75
|
+
),
|
|
76
|
+
"rate_limit_info": {
|
|
77
|
+
"limit": response.headers.get("X-RateLimit-Limit"),
|
|
78
|
+
"remaining": response.headers.get("X-RateLimit-Remaining"),
|
|
79
|
+
},
|
|
80
|
+
}
|
|
81
|
+
|
|
82
|
+
except requests.exceptions.RequestException as e:
|
|
83
|
+
if attempt < max_retries:
|
|
84
|
+
wait_time = 2**attempt
|
|
85
|
+
print(
|
|
86
|
+
f"Request failed: {str(e)}. Retrying in {wait_time} seconds..."
|
|
87
|
+
)
|
|
88
|
+
time.sleep(wait_time)
|
|
89
|
+
continue
|
|
90
|
+
else:
|
|
91
|
+
return {
|
|
92
|
+
"status": "error",
|
|
93
|
+
"error": f"ClinVar API request failed after {max_retries} retries: {str(e)}",
|
|
94
|
+
"url": url,
|
|
95
|
+
}
|
|
96
|
+
|
|
97
|
+
return {"status": "error", "error": "Maximum retries exceeded", "url": url}
|
|
98
|
+
|
|
99
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
100
|
+
"""Execute the tool with given arguments."""
|
|
101
|
+
return self._make_request(self.endpoint, arguments)
|
|
102
|
+
|
|
103
|
+
|
|
104
|
+
@register_tool("ClinVarSearchVariants")
|
|
105
|
+
class ClinVarSearchVariants(ClinVarRESTTool):
|
|
106
|
+
"""Search for variants in ClinVar by gene or condition."""
|
|
107
|
+
|
|
108
|
+
def __init__(self, tool_config):
|
|
109
|
+
super().__init__(tool_config)
|
|
110
|
+
self.endpoint = "/esearch.fcgi"
|
|
111
|
+
|
|
112
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
113
|
+
"""Search variants by gene or condition."""
|
|
114
|
+
params = {
|
|
115
|
+
"db": "clinvar",
|
|
116
|
+
"retmode": "json",
|
|
117
|
+
"retmax": arguments.get("max_results", 20),
|
|
118
|
+
}
|
|
119
|
+
|
|
120
|
+
# Build search query
|
|
121
|
+
query_parts = []
|
|
122
|
+
|
|
123
|
+
if "gene" in arguments:
|
|
124
|
+
query_parts.append(f"{arguments['gene']}[gene]")
|
|
125
|
+
|
|
126
|
+
if "condition" in arguments:
|
|
127
|
+
query_parts.append(f"{arguments['condition']}[condition]")
|
|
128
|
+
|
|
129
|
+
if "variant_id" in arguments:
|
|
130
|
+
query_parts.append(f"{arguments['variant_id']}[variant_id]")
|
|
131
|
+
|
|
132
|
+
if not query_parts:
|
|
133
|
+
return {
|
|
134
|
+
"status": "error",
|
|
135
|
+
"error": "At least one search parameter is required",
|
|
136
|
+
}
|
|
137
|
+
|
|
138
|
+
params["term"] = " AND ".join(query_parts)
|
|
139
|
+
|
|
140
|
+
result = self._make_request(self.endpoint, params)
|
|
141
|
+
|
|
142
|
+
# Add search parameters to result and format data
|
|
143
|
+
if result.get("status") == "success":
|
|
144
|
+
result["search_params"] = {
|
|
145
|
+
"gene": arguments.get("gene"),
|
|
146
|
+
"condition": arguments.get("condition"),
|
|
147
|
+
"variant_id": arguments.get("variant_id"),
|
|
148
|
+
}
|
|
149
|
+
|
|
150
|
+
# Format search results for better usability
|
|
151
|
+
data = result.get("data", {})
|
|
152
|
+
if "esearchresult" in data:
|
|
153
|
+
esearch = data["esearchresult"]
|
|
154
|
+
formatted_results = {
|
|
155
|
+
"total_count": int(esearch.get("count", 0)),
|
|
156
|
+
"variant_ids": esearch.get("idlist", []),
|
|
157
|
+
"query_translation": esearch.get("querytranslation", ""),
|
|
158
|
+
"search_params": result["search_params"],
|
|
159
|
+
"summary": f"Found {esearch.get('count', 0)} variants matching the search criteria",
|
|
160
|
+
}
|
|
161
|
+
result["formatted_results"] = formatted_results
|
|
162
|
+
|
|
163
|
+
return result
|
|
164
|
+
|
|
165
|
+
|
|
166
|
+
@register_tool("ClinVarGetVariantDetails")
|
|
167
|
+
class ClinVarGetVariantDetails(ClinVarRESTTool):
|
|
168
|
+
"""Get detailed variant information by ClinVar ID."""
|
|
169
|
+
|
|
170
|
+
def __init__(self, tool_config):
|
|
171
|
+
super().__init__(tool_config)
|
|
172
|
+
self.endpoint = "/esummary.fcgi"
|
|
173
|
+
|
|
174
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
175
|
+
"""Get variant details by ClinVar ID."""
|
|
176
|
+
variant_id = arguments.get("variant_id", "")
|
|
177
|
+
if not variant_id:
|
|
178
|
+
return {"status": "error", "error": "variant_id is required"}
|
|
179
|
+
|
|
180
|
+
params = {"db": "clinvar", "id": variant_id, "retmode": "json"}
|
|
181
|
+
|
|
182
|
+
result = self._make_request(self.endpoint, params)
|
|
183
|
+
|
|
184
|
+
# Add variant_id to result and format data
|
|
185
|
+
if result.get("status") == "success":
|
|
186
|
+
result["variant_id"] = variant_id
|
|
187
|
+
|
|
188
|
+
# Format the data for better usability
|
|
189
|
+
data = result.get("data", {})
|
|
190
|
+
if "result" in data and variant_id in data["result"]:
|
|
191
|
+
variant_data = data["result"][variant_id]
|
|
192
|
+
|
|
193
|
+
# Extract key information
|
|
194
|
+
formatted_data = {
|
|
195
|
+
"variant_id": variant_id,
|
|
196
|
+
"accession": variant_data.get("accession", ""),
|
|
197
|
+
"title": variant_data.get("title", ""),
|
|
198
|
+
"obj_type": variant_data.get("obj_type", ""),
|
|
199
|
+
"genes": [
|
|
200
|
+
gene.get("symbol", "") for gene in variant_data.get("genes", [])
|
|
201
|
+
],
|
|
202
|
+
"clinical_significance": variant_data.get(
|
|
203
|
+
"germline_classification", {}
|
|
204
|
+
).get("description", ""),
|
|
205
|
+
"review_status": variant_data.get(
|
|
206
|
+
"germline_classification", {}
|
|
207
|
+
).get("review_status", ""),
|
|
208
|
+
"chromosome": variant_data.get("chr_sort", ""),
|
|
209
|
+
"location": variant_data.get("variation_set", [{}])[0]
|
|
210
|
+
.get("variation_loc", [{}])[0]
|
|
211
|
+
.get("band", ""),
|
|
212
|
+
"variation_name": variant_data.get("variation_set", [{}])[0].get(
|
|
213
|
+
"variation_name", ""
|
|
214
|
+
),
|
|
215
|
+
"raw_data": variant_data, # Keep original data for advanced users
|
|
216
|
+
}
|
|
217
|
+
|
|
218
|
+
result["formatted_data"] = formatted_data
|
|
219
|
+
|
|
220
|
+
return result
|
|
221
|
+
|
|
222
|
+
|
|
223
|
+
@register_tool("ClinVarGetClinicalSignificance")
|
|
224
|
+
class ClinVarGetClinicalSignificance(ClinVarRESTTool):
|
|
225
|
+
"""Get clinical significance information for variants."""
|
|
226
|
+
|
|
227
|
+
def __init__(self, tool_config):
|
|
228
|
+
super().__init__(tool_config)
|
|
229
|
+
self.endpoint = "/esummary.fcgi"
|
|
230
|
+
|
|
231
|
+
def run(self, arguments: Dict[str, Any]) -> Dict[str, Any]:
|
|
232
|
+
"""Get clinical significance by variant ID."""
|
|
233
|
+
variant_id = arguments.get("variant_id", "")
|
|
234
|
+
if not variant_id:
|
|
235
|
+
return {"status": "error", "error": "variant_id is required"}
|
|
236
|
+
|
|
237
|
+
params = {"db": "clinvar", "id": variant_id, "retmode": "json"}
|
|
238
|
+
|
|
239
|
+
result = self._make_request(self.endpoint, params)
|
|
240
|
+
|
|
241
|
+
# Add variant_id to result and format clinical significance data
|
|
242
|
+
if result.get("status") == "success":
|
|
243
|
+
result["variant_id"] = variant_id
|
|
244
|
+
|
|
245
|
+
# Format the clinical significance data
|
|
246
|
+
data = result.get("data", {})
|
|
247
|
+
if "result" in data and variant_id in data["result"]:
|
|
248
|
+
variant_data = data["result"][variant_id]
|
|
249
|
+
|
|
250
|
+
# Extract clinical significance information
|
|
251
|
+
germline_class = variant_data.get("germline_classification", {})
|
|
252
|
+
clinical_impact = variant_data.get("clinical_impact_classification", {})
|
|
253
|
+
oncogenicity = variant_data.get("oncogenicity_classification", {})
|
|
254
|
+
|
|
255
|
+
formatted_data = {
|
|
256
|
+
"variant_id": variant_id,
|
|
257
|
+
"germline_classification": {
|
|
258
|
+
"description": germline_class.get("description", ""),
|
|
259
|
+
"review_status": germline_class.get("review_status", ""),
|
|
260
|
+
"last_evaluated": germline_class.get("last_evaluated", ""),
|
|
261
|
+
"fda_recognized": germline_class.get(
|
|
262
|
+
"fda_recognized_database", ""
|
|
263
|
+
),
|
|
264
|
+
"traits": [
|
|
265
|
+
trait.get("trait_name", "")
|
|
266
|
+
for trait in germline_class.get("trait_set", [])
|
|
267
|
+
],
|
|
268
|
+
},
|
|
269
|
+
"clinical_impact": {
|
|
270
|
+
"description": clinical_impact.get("description", ""),
|
|
271
|
+
"review_status": clinical_impact.get("review_status", ""),
|
|
272
|
+
"last_evaluated": clinical_impact.get("last_evaluated", ""),
|
|
273
|
+
},
|
|
274
|
+
"oncogenicity": {
|
|
275
|
+
"description": oncogenicity.get("description", ""),
|
|
276
|
+
"review_status": oncogenicity.get("review_status", ""),
|
|
277
|
+
"last_evaluated": oncogenicity.get("last_evaluated", ""),
|
|
278
|
+
},
|
|
279
|
+
"raw_data": variant_data, # Keep original data for advanced users
|
|
280
|
+
}
|
|
281
|
+
|
|
282
|
+
result["formatted_data"] = formatted_data
|
|
283
|
+
|
|
284
|
+
return result
|