ivoryos 0.1.8__tar.gz → 0.1.10__tar.gz

This diff represents the content of publicly available package versions that have been released to one of the supported registries. The information contained in this diff is provided for informational purposes only and reflects changes between package versions as they appear in their respective public registries.
Files changed (53) hide show
  1. {ivoryos-0.1.8 → ivoryos-0.1.10}/LICENSE +21 -21
  2. {ivoryos-0.1.8 → ivoryos-0.1.10}/MANIFEST.in +7 -7
  3. {ivoryos-0.1.8/ivoryos.egg-info → ivoryos-0.1.10}/PKG-INFO +162 -166
  4. {ivoryos-0.1.8 → ivoryos-0.1.10}/README.md +151 -147
  5. {ivoryos-0.1.8 → ivoryos-0.1.10/ivoryOS.egg-info}/PKG-INFO +162 -166
  6. {ivoryos-0.1.8/ivoryos.egg-info → ivoryos-0.1.10/ivoryOS.egg-info}/SOURCES.txt +7 -0
  7. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/__init__.py +118 -99
  8. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/config.py +47 -47
  9. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/auth/auth.py +100 -65
  10. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/auth/templates/auth/login.html +25 -25
  11. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/auth/templates/auth/signup.html +32 -32
  12. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/control/control.py +400 -272
  13. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/control/templates/control/controllers.html +75 -75
  14. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/control/templates/control/controllers_home.html +50 -50
  15. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/control/templates/control/controllers_new.html +89 -89
  16. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/database/database.py +188 -114
  17. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/database/templates/database/experiment_database.html +72 -72
  18. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/design/design.py +542 -406
  19. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/design/templates/design/experiment_builder.html +415 -412
  20. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/design/templates/design/experiment_run.html +325 -325
  21. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/main/main.py +42 -25
  22. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/main/templates/main/help.html +141 -141
  23. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/main/templates/main/home.html +68 -68
  24. ivoryos-0.1.10/ivoryos/static/.DS_Store +0 -0
  25. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/js/overlay.js +12 -12
  26. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/js/socket_handler.js +34 -34
  27. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/js/sortable_card.js +24 -24
  28. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/js/sortable_design.js +36 -36
  29. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/style.css +201 -201
  30. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/templates/base.html +143 -143
  31. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/db_models.py +518 -500
  32. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/form.py +316 -316
  33. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/global_config.py +67 -67
  34. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/llm_agent.py +183 -183
  35. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/script_runner.py +165 -164
  36. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/utils.py +425 -422
  37. ivoryos-0.1.10/ivoryos/version.py +1 -0
  38. {ivoryos-0.1.8 → ivoryos-0.1.10}/setup.cfg +4 -4
  39. {ivoryos-0.1.8 → ivoryos-0.1.10}/setup.py +28 -27
  40. {ivoryos-0.1.8/ivoryos.egg-info → ivoryos-0.1.10/ivoryOS.egg-info}/dependency_links.txt +0 -0
  41. {ivoryos-0.1.8/ivoryos.egg-info → ivoryos-0.1.10/ivoryOS.egg-info}/requires.txt +0 -0
  42. {ivoryos-0.1.8/ivoryos.egg-info → ivoryos-0.1.10/ivoryOS.egg-info}/top_level.txt +0 -0
  43. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/__init__.py +0 -0
  44. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/auth/__init__.py +0 -0
  45. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/control/__init__.py +0 -0
  46. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/database/__init__.py +0 -0
  47. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/design/__init__.py +0 -0
  48. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/routes/main/__init__.py +0 -0
  49. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/favicon.ico +0 -0
  50. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/gui_annotation/Slide1.png +0 -0
  51. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/gui_annotation/Slide2.PNG +0 -0
  52. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/static/logo.webp +0 -0
  53. {ivoryos-0.1.8 → ivoryos-0.1.10}/ivoryos/utils/__init__.py +0 -0
@@ -1,21 +1,21 @@
1
- MIT License
2
-
3
- Copyright (c) 2023-2024 Ivory Zhang | Hein Lab
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-
5
- Permission is hereby granted, free of charge, to any person obtaining a copy
6
- of this software and associated documentation files (the "Software"), to deal
7
- in the Software without restriction, including without limitation the rights
8
- to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
9
- copies of the Software, and to permit persons to whom the Software is
10
- furnished to do so, subject to the following conditions:
11
-
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- The above copyright notice and this permission notice shall be included in
13
- all copies or substantial portions of the Software.
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-
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- THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
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- IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
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- FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
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- AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
19
- LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
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- OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
21
- THE SOFTWARE.
1
+ MIT License
2
+
3
+ Copyright (c) 2023-2024 Ivory Zhang | Hein Lab
4
+
5
+ Permission is hereby granted, free of charge, to any person obtaining a copy
6
+ of this software and associated documentation files (the "Software"), to deal
7
+ in the Software without restriction, including without limitation the rights
8
+ to use, copy, modify, merge, publish, distribute, sublicense, and/or sell
9
+ copies of the Software, and to permit persons to whom the Software is
10
+ furnished to do so, subject to the following conditions:
11
+
12
+ The above copyright notice and this permission notice shall be included in
13
+ all copies or substantial portions of the Software.
14
+
15
+ THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
16
+ IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
17
+ FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
18
+ AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
19
+ LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
20
+ OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN
21
+ THE SOFTWARE.
@@ -1,8 +1,8 @@
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- graft ivoryos/static
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- graft ivoryos/templates
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- graft ivoryos/routes
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- global-exclude *.pyc
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-
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- # exclude examples
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- prune ivoryos/example
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+ graft ivoryos/static
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+ graft ivoryos/templates
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+ graft ivoryos/routes
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+ global-exclude *.pyc
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+
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+ # exclude examples
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+ prune ivoryos/example
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  prune ivoryos/docs
@@ -1,166 +1,162 @@
1
- Metadata-Version: 2.1
2
- Name: ivoryos
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- Version: 0.1.8
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- Summary: an open-source Python package enabling Self-Driving Labs (SDLs) interoperability
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- Home-page: https://gitlab.com/heingroup/ivoryos
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- Author: Ivory Zhang
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- Author-email: ivoryzhang@chem.ubc.ca
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- License: MIT
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- Description-Content-Type: text/markdown
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- License-File: LICENSE
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- Requires-Dist: bcrypt
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- Requires-Dist: Flask-Login
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- Requires-Dist: Flask-Session
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- Requires-Dist: Flask-SocketIO
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- Requires-Dist: Flask-SQLAlchemy
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- Requires-Dist: Flask-WTF
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- Requires-Dist: SQLAlchemy-Utils
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- Requires-Dist: python-dotenv
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-
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- ![](https://gitlab.com/heingroup/ivoryos/raw/main/docs/ivoryos.png)
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- # ivoryOS: interoperable Web UI for self-driving laboratories (SDLs)
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- "plug and play" web UI extension for flexible SDLs.
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-
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- ## Table of Contents
25
- - [Description](#description)
26
- - [System requirements](#system-requirements)
27
- - [Installation](#installation)
28
- - [Instructions for use](#instructions-for-use)
29
- - [Demo](#demo)
30
- - [License](#license)
31
-
32
- ## Description
33
- Granting SDLs flexibility and modularity makes it almost impossible to design a UI, yet it's a necessity for allowing more people to interact with it (democratisation).
34
- This web UI aims to ease up the control of any Python-based SDLs by displaying functions and parameters for initialized modules dynamically.
35
- The modules can be hardware API, high-level functions, or experiment workflow.
36
- With the least modification of the current workflow, user can design, manage and execute their experimental designs and monitor the execution process.
37
-
38
- ## System requirements
39
- This software is developed and tested using Windows. This software and its dependencies are compatible across major platforms: Linux, macOS, and Windows. Some dependencies (Flask-SQLAlchemy) may require additional setup.
40
-
41
- ### Python Version
42
- Python >=3.7 for best compatibility.
43
- ### Python dependencies
44
- This software is compatible with the latest versions of all dependencies.
45
- - bcrypt~=4.0
46
- - Flask-Login~=0.6
47
- - Flask-Session~=0.8
48
- - Flask-SocketIO~=5.3
49
- - Flask-SQLAlchemy~=3.1
50
- - SQLAlchemy-Utils~=0.41
51
- - Flask-WTF~=1.2
52
- - python-dotenv==1.0.1
53
- - openai (optional ~=1.53)
54
- - ax-platform (optional ~=0.3 or ~=0.4 for Python>=3.9)
55
-
56
- ## Installation
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- ```bash
58
- pip install ivoryos
59
- ```
60
- or
61
- ```bash
62
- git clone https://gitlab.com/heingroup/ivoryos.git
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- cd ivoryos
64
- pip install -e .
65
- ```
66
-
67
- The installation may take 10 to 30 seconds to install. The installation time may vary and take up to several minutes, depending on the network speed, computer performance, and virtual environment settings.
68
-
69
- ## Instructions for use
70
- ### Quick start
71
- In your SDL script, use `ivoryos(__name__)`.
72
- ```python
73
- import ivoryos
74
-
75
- ivoryos.run(__name__)
76
- ```
77
- ### Login
78
- Create an account and login (local database)
79
- ### Features
80
- - **Direct control**: direct function calling _Device_ tab
81
- - **Workflow design and iteration**:
82
- - **Design**: add function to canvas in _Design_ tab. click `Compile and Run` button to go to the execution page
83
- - **Execution**: configure iteration methods and parameters in _Compile/Run_ tab.
84
- - **Database**: manage workflows in _Library_ tab.
85
- - **Info page**: additional info in _About_ tab.
86
-
87
-
88
- ### Additional settings
89
- #### AI assistant
90
- To streamline the experimental design on SDLs, we also integrate Large Language Models (LLMs) to interpret the inspected functions and generate code according to task descriptions.
91
-
92
- #### Enable LLMs with [OpenAI API](https://github.com/openai/openai-python)
93
- 1. Create a `.env` file for `OPENAI_API_KEY`
94
- ```
95
- OPENAI_API_KEY="Your API Key"
96
- ```
97
- 2. In your SDL script, define model, you can use any GPT models.
98
-
99
- ```python
100
- ivoryos.run(__name__, model="gpt-3.5-turbo")
101
- ```
102
-
103
- #### Enable local LLMs with [Ollama](https://ollama.com/)
104
- 1. Download Ollama.
105
- 2. pull models from Ollama
106
- 3. In your SDL script, define LLM server and model, you can use any models available on Ollama.
107
-
108
- ```python
109
- ivoryos.run(__name__, llm_server="localhost", model="llama3.1")
110
- ```
111
-
112
- #### Add additional logger(s)
113
- ```python
114
- ivoryos.run(__name__, logger="logger name")
115
- ```
116
- or
117
- ```python
118
- ivoryos.run(__name__, logger=["logger 1", "logger 2"])
119
- ```
120
- #### Offline (design without hardware connection)
121
- After one successful connection, a blueprint will be automatically saved and made accessible without hardware connection. In a new Python script in the same directory, use `ivoryos.run()` to start offline mode.
122
-
123
- ```python
124
- ivoryos.run()
125
- ```
126
- ## Demo
127
- In the [abstract_sdl.py](https://gitlab.com/heingroup/ivoryos/-/blob/main/example/sdl_example/abstract_sdl.py), where instances of `AbstractSDL` is created as `sdl`,
128
- addresses will be available on terminal.
129
- ```Python
130
- ivoryos.run(__name__)
131
- ```
132
-
133
- * Running on all addresses (0.0.0.0)
134
- * Running on http://127.0.0.1:8000
135
- * Running on http://xxx.xx.xx.xxx:8000
136
-
137
- ### Deck function and web form
138
- ![](https://gitlab.com/heingroup/ivoryos/raw/main/docs/demo.gif)
139
-
140
- ### Directory structure
141
-
142
- When you run the application for the first time, it will automatically create the following folders and files in the same directory:
143
-
144
- - **`ivoryos_data/`**: Main directory for application-related data.
145
- - **`ivoryos_data/config_csv/`**: Contains iteration configuration files in CSV format.
146
- - **`ivoryos_data/llm_output/`**: Stores raw prompt generated for the large language model.
147
- - **`ivoryos_data/pseudo_deck/`**: Contains pseudo-deck `.pkl` files for offline access.
148
- - **`ivoryos_data/results/`**: Used for storing results or outputs during workflow execution.
149
- - **`ivoryos_data/scripts/`**: Holds Python scripts compiled from the visual programming script design.
150
-
151
- - **`default.log`**: Log file that captures application logs.
152
- - **`ivoryos.db`**: Database file that stores application data locally.
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-
154
-
155
- ### Demo video
156
- Intro + Tutorial + Demo with PurPOSE platform
157
- https://youtu.be/dFfJv9I2-1g
158
-
159
-
160
- ## Authors and Acknowledgement
161
- Ivory Zhang, Lucy Hao
162
-
163
- Authors acknowledge all former and current Hein Lab members for their valuable suggestions.
164
-
165
- ## License
166
- [LICENSE](LICENSE)
1
+ Metadata-Version: 2.1
2
+ Name: ivoryos
3
+ Version: 0.1.10
4
+ Summary: an open-source Python package enabling Self-Driving Labs (SDLs) interoperability
5
+ Home-page: https://gitlab.com/heingroup/ivoryos
6
+ Author: Ivory Zhang
7
+ Author-email: ivoryzhang@chem.ubc.ca
8
+ License: MIT
9
+ Description-Content-Type: text/markdown
10
+ License-File: LICENSE
11
+
12
+ [![Documentation Status](https://readthedocs.org/projects/ivoryos/badge/?version=latest)](https://ivoryos.readthedocs.io/en/latest/?badge=latest)
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+ [![PyPI version](https://img.shields.io/pypi/v/ivoryos)](https://pypi.org/project/ivoryos/)
14
+ ![License](https://img.shields.io/pypi/l/ivoryos)
15
+
16
+ ![](https://gitlab.com/heingroup/ivoryos/raw/main/docs/source/_static/ivoryos.png)
17
+ # ivoryOS: interoperable Web UI for self-driving laboratories (SDLs)
18
+ "plug and play" web UI extension for flexible SDLs.
19
+
20
+ ## Table of Contents
21
+ - [Description](#description)
22
+ - [System requirements](#system-requirements)
23
+ - [Installation](#installation)
24
+ - [Instructions for use](#instructions-for-use)
25
+ - [Demo](#demo)
26
+ - [License](#license)
27
+
28
+ ## Description
29
+ Granting SDLs flexibility and modularity makes it almost impossible to design a UI, yet it's a necessity for allowing more people to interact with it (democratisation).
30
+ This web UI aims to ease up the control of any Python-based SDLs by displaying functions and parameters for initialized modules dynamically.
31
+ The modules can be hardware API, high-level functions, or experiment workflow.
32
+ With the least modification of the current workflow, user can design, manage and execute their experimental designs and monitor the execution process.
33
+
34
+ ## System requirements
35
+ This software is developed and tested using Windows. This software and its dependencies are compatible across major platforms: Linux, macOS, and Windows. Some dependencies (Flask-SQLAlchemy) may require additional setup.
36
+
37
+ ### Python Version
38
+ Python >=3.7 for best compatibility.
39
+ ### Python dependencies
40
+ This software is compatible with the latest versions of all dependencies.
41
+ - bcrypt~=4.0
42
+ - Flask-Login~=0.6
43
+ - Flask-Session~=0.8
44
+ - Flask-SocketIO~=5.3
45
+ - Flask-SQLAlchemy~=3.1
46
+ - SQLAlchemy-Utils~=0.41
47
+ - Flask-WTF~=1.2
48
+ - python-dotenv==1.0.1
49
+ - openai (optional ~=1.53)
50
+ - ax-platform (optional ~=0.3 or ~=0.4 for Python>=3.9)
51
+
52
+ ## Installation
53
+ ```bash
54
+ pip install ivoryos
55
+ ```
56
+ or
57
+ ```bash
58
+ git clone https://gitlab.com/heingroup/ivoryos.git
59
+ cd ivoryos
60
+ pip install -e .
61
+ ```
62
+
63
+ The installation may take 10 to 30 seconds to install. The installation time may vary and take up to several minutes, depending on the network speed, computer performance, and virtual environment settings.
64
+
65
+ ## Instructions for use
66
+ ### Quick start
67
+ In your SDL script, use `ivoryos(__name__)`.
68
+ ```python
69
+ import ivoryos
70
+
71
+ ivoryos.run(__name__)
72
+ ```
73
+ ### Login
74
+ Create an account and login (local database)
75
+ ### Features
76
+ - **Direct control**: direct function calling _Device_ tab
77
+ - **Workflow design and iteration**:
78
+ - **Design**: add function to canvas in _Design_ tab. click `Compile and Run` button to go to the execution page
79
+ - **Execution**: configure iteration methods and parameters in _Compile/Run_ tab.
80
+ - **Database**: manage workflows in _Library_ tab.
81
+ - **Info page**: additional info in _About_ tab.
82
+
83
+
84
+ ### Additional settings
85
+ #### AI assistant
86
+ To streamline the experimental design on SDLs, we also integrate Large Language Models (LLMs) to interpret the inspected functions and generate code according to task descriptions.
87
+
88
+ #### Enable LLMs with [OpenAI API](https://github.com/openai/openai-python)
89
+ 1. Create a `.env` file for `OPENAI_API_KEY`
90
+ ```
91
+ OPENAI_API_KEY="Your API Key"
92
+ ```
93
+ 2. In your SDL script, define model, you can use any GPT models.
94
+
95
+ ```python
96
+ ivoryos.run(__name__, model="gpt-3.5-turbo")
97
+ ```
98
+
99
+ #### Enable local LLMs with [Ollama](https://ollama.com/)
100
+ 1. Download Ollama.
101
+ 2. pull models from Ollama
102
+ 3. In your SDL script, define LLM server and model, you can use any models available on Ollama.
103
+
104
+ ```python
105
+ ivoryos.run(__name__, llm_server="localhost", model="llama3.1")
106
+ ```
107
+
108
+ #### Add additional logger(s)
109
+ ```python
110
+ ivoryos.run(__name__, logger="logger name")
111
+ ```
112
+ or
113
+ ```python
114
+ ivoryos.run(__name__, logger=["logger 1", "logger 2"])
115
+ ```
116
+ #### Offline (design without hardware connection)
117
+ After one successful connection, a blueprint will be automatically saved and made accessible without hardware connection. In a new Python script in the same directory, use `ivoryos.run()` to start offline mode.
118
+
119
+ ```python
120
+ ivoryos.run()
121
+ ```
122
+ ## Demo
123
+ In the [abstract_sdl.py](https://gitlab.com/heingroup/ivoryos/-/blob/main/example/sdl_example/abstract_sdl.py), where instances of `AbstractSDL` is created as `sdl`,
124
+ addresses will be available on terminal.
125
+ ```Python
126
+ ivoryos.run(__name__)
127
+ ```
128
+
129
+ * Running on all addresses (0.0.0.0)
130
+ * Running on http://127.0.0.1:8000
131
+ * Running on http://xxx.xx.xx.xxx:8000
132
+
133
+ ### Deck function and web form
134
+ ![](https://gitlab.com/heingroup/ivoryos/raw/main/docs/source/_static/demo.gif)
135
+
136
+ ### Text-to-code demo
137
+ ![](https://gitlab.com/heingroup/ivoryos/raw/main/docs/source/_static/text-to-code.gif)
138
+
139
+ ### Directory structure
140
+
141
+ When you run the application for the first time, it will automatically create the following folders and files in the same directory:
142
+
143
+ - **`ivoryos_data/`**: Main directory for application-related data.
144
+ - **`ivoryos_data/config_csv/`**: Contains iteration configuration files in CSV format.
145
+ - **`ivoryos_data/llm_output/`**: Stores raw prompt generated for the large language model.
146
+ - **`ivoryos_data/pseudo_deck/`**: Contains pseudo-deck `.pkl` files for offline access.
147
+ - **`ivoryos_data/results/`**: Used for storing results or outputs during workflow execution.
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+ - **`ivoryos_data/scripts/`**: Holds Python scripts compiled from the visual programming script design.
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+
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+ - **`default.log`**: Log file that captures application logs.
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+ - **`ivoryos.db`**: Database file that stores application data locally.
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+
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+
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+ ### Demo video
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+ Intro + Tutorial + Demo with PurPOSE platform
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+ https://youtu.be/dFfJv9I2-1g
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+
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+
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+ ## Authors and Acknowledgement
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+ Ivory Zhang, Lucy Hao
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+
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+ Authors acknowledge all former and current Hein Lab members for their valuable suggestions.