SigProfilerAssignment 1.0.4__tar.gz → 1.1.0__tar.gz

{sigprofilerassignment-1.0.4/SigProfilerAssignment.egg-info → sigprofilerassignment-1.1.0}/PKG-INFO

@@ -1,6 +1,6 @@
 Metadata-Version: 2.4
 Name: SigProfilerAssignment
-Version: 1.0.4
+Version: 1.1.0
 Summary: Mutational signatures attribution and decomposition tool
 Home-page: https://github.com/AlexandrovLab/SigProfilerAssignment.git
 Author: Raviteja Vangara
@@ -76,12 +76,12 @@ If you plan to use `sample_reconstruction_plots='png'` or `'both'`, the external
 
 ## <a name="running"></a> Running
 
-Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files or mutational matrices. COSMIC mutational signatures v3.4 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
+Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files or mutational matrices. COSMIC mutational signatures v3.5 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
 
 ```python
 from SigProfilerAssignment import Analyzer as Analyze
 Analyze.cosmic_fit(samples, output, input_type="matrix", context_type="96",
-                   collapse_to_SBS96=True, cosmic_version=3.4, exome=False,
+                   collapse_to_SBS96=True, cosmic_version=3.5, exome=False,
                    genome_build="GRCh37", signature_database=None,
                    exclude_signature_subgroups=None, export_probabilities=False,
                    export_probabilities_per_mutation=False, make_plots=False,
@@ -98,7 +98,7 @@ Analyze.cosmic_fit(samples, output, input_type="matrix", context_type="96",
 | output | String | Path to the output folder. |
 | input_type | String | Three accepted input types:<ul><li> "vcf": if using mutation calling file/s (VCF, MAF, simple text file) as input</li><li>"seg:TYPE": if using a segmentation file as input. Please check the required format at https://github.com/AlexandrovLab/SigProfilerMatrixGenerator#copy-number-matrix-generation. The accepted callers for TYPE are the following {"ASCAT", "ASCAT_NGS", "SEQUENZA", "ABSOLUTE", "BATTENBERG", "FACETS", "PURPLE", "TCGA"}. For example:"seg:BATTENBERG"</li><li>"matrix": if using a mutational matrix as input</li></ul>The default value is "matrix". |
 | context_type | String | Required context type if `input_type` is "vcf". `context_type` takes which context type of the input data is considered for assignment. Valid options include "96", "288", "1536", "DINUC", and "ID". The default value is "96". |
-| cosmic_version | Float | Defines the version of the COSMIC reference signatures. Takes a positive float among 1, 2, 3, 3.1, 3.2, 3.3, and 3.4. The default value is 3.4. |
+| cosmic_version | Float | Defines the version of the COSMIC reference signatures. Takes a positive float among 1, 2, 3, 3.1, 3.2, 3.3, 3.4, and 3.5. The default value is 3.5. |
 | exome | Boolean | Defines if the exome renormalized COSMIC signatures will be used. The default value is False. |
 | genome_build | String | The reference genome build, used for select the appropriate version of the COSMIC reference signatures, as well as processing the mutation calling file/s. Supported genomes include "GRCh37", "GRCh38", "mm9", "mm10" and "rn6". The default value is "GRCh37". If the selected genome is not in the supported list, the default genome will be used. |
 | signature_database | String | Path to the input set of known mutational signatures (only in case that COSMIC reference signatures are not used), a tab delimited file that contains the signature matrix where the rows are mutation types and columns are signature IDs. |
@@ -147,7 +147,7 @@ The full list of signature subgroups is included in the following table:
 |Immunosuppressants_signatures| 32|                             -|      -|
 |Treatment_signatures|          11, 25, 31, 32, 35, 86, 87, 90, 99| 5|      -|
 |APOBEC_signatures|             2, 13|                          -|      -|
-|Tobacco_signatures |           4, 29, 92|                      2|      3|
+|Tobacco_signatures |           4, 29, 92, 100, 109|                      2|      3|
 |UV_signatures|                 7a, 7b, 7c, 7d, 38|             1|      13|
 |AA_signatures|                 22a, 22b|                             20|      23|
 |Colibactin_signatures|         88|                             -|      18|
@@ -169,7 +169,7 @@ Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/vcf_input",
                    input_type="vcf",
                    context_type="96",
                    genome_build="GRCh37",
-                   cosmic_version=3.4)
+                   cosmic_version=3.5)
 ```
 
 
@@ -182,7 +182,7 @@ from SigProfilerAssignment import Analyzer as Analyze
 Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/cnv_input/all.breast.ascat.summary.sample.tsv", 
                    output="example_sf",
                    input_type="seg:ASCAT_NGS",
-                   cosmic_version=3.4,
+                   cosmic_version=3.5,
                    collapse_to_SBS96=False)
 ```
 
@@ -196,7 +196,7 @@ Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/txt_input/sample_matrix_
                    output="example_mm",
                    input_type="matrix",
                    genome_build="GRCh37",
-                   cosmic_version=3.4)
+                   cosmic_version=3.5)
 ```
 
 ## <a name="denovo"></a> _De novo_ extraction of mutational signatures downstream analysis

{sigprofilerassignment-1.0.4 → sigprofilerassignment-1.1.0}/README.md

@@ -42,12 +42,12 @@ If you plan to use `sample_reconstruction_plots='png'` or `'both'`, the external
 
 ## <a name="running"></a> Running
 
-Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files or mutational matrices. COSMIC mutational signatures v3.4 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
+Assignment of known mutational signatures to individual samples is performed using the `cosmic_fit` function. Input samples are provided using the `samples` parameter in the form of mutation calling files (VCFs, MAFs, or simple text files), segmentation files or mutational matrices. COSMIC mutational signatures v3.5 are used as the default reference signatures, although previous COSMIC versions and custom signature databases are also supported using the `cosmic_version` and `signature_database` parameters. Results will be found in the folder specified in the `output` parameter.
 
 ```python
 from SigProfilerAssignment import Analyzer as Analyze
 Analyze.cosmic_fit(samples, output, input_type="matrix", context_type="96",
-                   collapse_to_SBS96=True, cosmic_version=3.4, exome=False,
+                   collapse_to_SBS96=True, cosmic_version=3.5, exome=False,
                    genome_build="GRCh37", signature_database=None,
                    exclude_signature_subgroups=None, export_probabilities=False,
                    export_probabilities_per_mutation=False, make_plots=False,
@@ -64,7 +64,7 @@ Analyze.cosmic_fit(samples, output, input_type="matrix", context_type="96",
 | output | String | Path to the output folder. |
 | input_type | String | Three accepted input types:<ul><li> "vcf": if using mutation calling file/s (VCF, MAF, simple text file) as input</li><li>"seg:TYPE": if using a segmentation file as input. Please check the required format at https://github.com/AlexandrovLab/SigProfilerMatrixGenerator#copy-number-matrix-generation. The accepted callers for TYPE are the following {"ASCAT", "ASCAT_NGS", "SEQUENZA", "ABSOLUTE", "BATTENBERG", "FACETS", "PURPLE", "TCGA"}. For example:"seg:BATTENBERG"</li><li>"matrix": if using a mutational matrix as input</li></ul>The default value is "matrix". |
 | context_type | String | Required context type if `input_type` is "vcf". `context_type` takes which context type of the input data is considered for assignment. Valid options include "96", "288", "1536", "DINUC", and "ID". The default value is "96". |
-| cosmic_version | Float | Defines the version of the COSMIC reference signatures. Takes a positive float among 1, 2, 3, 3.1, 3.2, 3.3, and 3.4. The default value is 3.4. |
+| cosmic_version | Float | Defines the version of the COSMIC reference signatures. Takes a positive float among 1, 2, 3, 3.1, 3.2, 3.3, 3.4, and 3.5. The default value is 3.5. |
 | exome | Boolean | Defines if the exome renormalized COSMIC signatures will be used. The default value is False. |
 | genome_build | String | The reference genome build, used for select the appropriate version of the COSMIC reference signatures, as well as processing the mutation calling file/s. Supported genomes include "GRCh37", "GRCh38", "mm9", "mm10" and "rn6". The default value is "GRCh37". If the selected genome is not in the supported list, the default genome will be used. |
 | signature_database | String | Path to the input set of known mutational signatures (only in case that COSMIC reference signatures are not used), a tab delimited file that contains the signature matrix where the rows are mutation types and columns are signature IDs. |
@@ -113,7 +113,7 @@ The full list of signature subgroups is included in the following table:
 |Immunosuppressants_signatures| 32|                             -|      -|
 |Treatment_signatures|          11, 25, 31, 32, 35, 86, 87, 90, 99| 5|      -|
 |APOBEC_signatures|             2, 13|                          -|      -|
-|Tobacco_signatures |           4, 29, 92|                      2|      3|
+|Tobacco_signatures |           4, 29, 92, 100, 109|                      2|      3|
 |UV_signatures|                 7a, 7b, 7c, 7d, 38|             1|      13|
 |AA_signatures|                 22a, 22b|                             20|      23|
 |Colibactin_signatures|         88|                             -|      18|
@@ -135,7 +135,7 @@ Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/vcf_input",
                    input_type="vcf",
                    context_type="96",
                    genome_build="GRCh37",
-                   cosmic_version=3.4)
+                   cosmic_version=3.5)
 ```
 
 
@@ -148,7 +148,7 @@ from SigProfilerAssignment import Analyzer as Analyze
 Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/cnv_input/all.breast.ascat.summary.sample.tsv", 
                    output="example_sf",
                    input_type="seg:ASCAT_NGS",
-                   cosmic_version=3.4,
+                   cosmic_version=3.5,
                    collapse_to_SBS96=False)
 ```
 
@@ -162,7 +162,7 @@ Analyze.cosmic_fit(samples=spa.__path__[0]+"/data/tests/txt_input/sample_matrix_
                    output="example_mm",
                    input_type="matrix",
                    genome_build="GRCh37",
-                   cosmic_version=3.4)
+                   cosmic_version=3.5)
 ```
 
 ## <a name="denovo"></a> _De novo_ extraction of mutational signatures downstream analysis

{sigprofilerassignment-1.0.4 → sigprofilerassignment-1.1.0}/SigProfilerAssignment/Analyzer.py

@@ -10,7 +10,7 @@ def decompose_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.4,
+    cosmic_version=3.5,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,
@@ -67,7 +67,7 @@ def denovo_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.4,
+    cosmic_version=3.5,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,
@@ -122,7 +122,7 @@ def cosmic_fit(
     nnls_remove_penalty=0.01,
     initial_remove_penalty=0.05,
     genome_build="GRCh37",
-    cosmic_version=3.4,
+    cosmic_version=3.5,
     make_plots=True,
     collapse_to_SBS96=True,
     connected_sigs=True,

{sigprofilerassignment-1.0.4 → sigprofilerassignment-1.1.0}/SigProfilerAssignment/DecompositionPlots/PlotDecomposition.py

@@ -77,7 +77,7 @@ cosmic_template_path = os.path.join(DECOMPOSITION_PATH, "CosmicTemplates")
 def install_cosmic_plots(
     context_type="96",
     genome_build="GRCh37",
-    cosmic_version="3.4",
+    cosmic_version="3.5",
     exome=False,
     volume=None,
 ):
@@ -898,7 +898,7 @@ def run_PlotDecomposition(
     output_path,
     project,
     mtype,
-    cosmic_version="3.4",
+    cosmic_version="3.5",
     genome_build="GRCh37",
     exome=False,
     custom_text=None,
@@ -1042,7 +1042,7 @@ def run_PlotSSDecomposition(
     project,
     context_type,
     genome_build="GRCh37",
-    cosmic_version="3.4",
+    cosmic_version="3.5",
     custom_text=None,
     exome=False,
     volume=None,

{sigprofilerassignment-1.0.4 → sigprofilerassignment-1.1.0}/SigProfilerAssignment/controllers/cli_controller.py

@@ -50,8 +50,8 @@ def parse_arguments_common(args: List[str], description: str) -> argparse.Namesp
     parser.add_argument(
         "--cosmic_version",
         type=float,
-        default=3.4,
-        help="COSMIC version (default: 3.4). Valid options: {1, 2, 3, 3.1, 3.2, 3.3, 3.4}.",
+        default=3.5,
+        help="COSMIC version (default: 3.5). Valid options: {1, 2, 3, 3.1, 3.2, 3.3, 3.4, 3.5}.",
     )
     parser.add_argument(
         "--make_plots",

sigprofilerassignment-1.1.0/SigProfilerAssignment/data/Reference_Signatures/GRCh37/COSMIC_v3.5_CN_GRCh37.txt

@@ -0,0 +1,49 @@
+Type	CN1	CN2	CN3	CN4	CN5	CN6	CN7	CN8	CN9	CN10	CN11	CN12	CN13	CN14	CN15	CN16	CN17	CN18	CN19	CN20	CN21	CN22	CN23	CN24	CN25	CN26
+0:homdel:0-100kb	0.001795054	0.002237674	0.064044243	0.00096628	0.02582249	0.0034925	0.0	0.00021626	0.008181842	0.00779524	0.00161374	0.02309338	0.00224368	0.0121477	0.0067438	0.0036673	0.00136668	0.00110894	0.00591472	4.08e-05	5.5e-07	0.266866171	0.24410253	0.000371716	0.006074244	0.00922234
+0:homdel:100kb-1Mb	0.003807104	0.007195788	0.00640384	0.00021955	0.02499357	0.007550309	0.0	0.000720975	0.020999189	0.03122532	0.0059027	0.052724771	0.03467842	0.03389276	0.02652628	0.00109281	0.00143123	0.00303045	0.00677398	0.00017845	0.00022928	0.02038467	0.02413956	0.000760546	0.009107288	0.01269433
+0:homdel:>1Mb	0.002436746	0.003837108	0.013033431	6.12e-05	0.0038887	0.00133617	0.0	0.00026934	0.009009219	0.00455881	0.00313081	0.0068661	0.01814564	4.4e-07	0.00524487	0.04053983	0.0014533	0.0007584	0.0041105	0.00011722	0.00135207	0.001282235	0.00355824	0.000575594	0.004061581	0.00522882
+1:LOH:0-100kb	0.002840449	0.002826536	0.062213582	0.056150771	0.015829115	0.00595583	0.00011082	0.000950405	0.018583652	0.00879753	0.0027543	0.02182354	0.00284705	0.00129939	0.00763888	0.00142666	0.00211427	0.0015556	0.01041569	0.00050182	0.0002482	0.02147356	0.13028998	0.000635022	0.142313643	0.00718471
+1:LOH:100kb-1Mb	0.012263057	0.006323915	0.012614821	0.247798925	0.02654494	0.010520759	0.0050408	0.00728363	0.130807872	0.03974523	0.0062317	0.065977011	0.02886982	0.01293743	0.00252662	0.00580905	0.00507205	0.00141876	0.064293751	0.00081924	0.0123588	0.034899515	0.0768859	0.004601138	0.310351003	0.02106504
+1:LOH:1Mb-10Mb	0.019163418	0.001023764	0.019283461	0.083369342	0.00135803	0.00099151	7.44e-05	0.002204905	0.159949199	0.01091525	0.01775071	0.00423455	0.12860718	2.02e-05	1e-07	0.00343106	0.0186884	0.00028103	0.03777062	0.00624116	0.05642821	0.024426895	0.03485188	0.004307654	0.026957401	0.01530544
+1:LOH:10Mb-40Mb	0.047297757	0.000483364	0.0087199	0.00010096	0.000573685	0.00040994	2e-08	0.00366415	0.076229355	0.00290428	0.00184154	4.03e-05	0.1541978	1.4e-07	4.4e-07	0.00204512	0.00550295	8e-08	0.02105378	0.00283775	0.04607252	0.003555775	0.02090447	0.002622552	0.002556706	0.01289555
+1:LOH:>40Mb	0.073645999	0.000124322	0.00409212	0.00230378	8.1e-05	0.00017917	0.0	0.006089315	0.027000693	0.00148398	5.75e-05	4.64e-06	0.21568204	1.87e-06	0.0003073	0.00064424	1.34e-06	1.65e-06	0.00174097	1.2e-05	0.01887089	0.002450425	0.00226301	0.00227007	0.000974623	0.00805582
+2:LOH:0-100kb	0.001187984	0.002488917	0.00138849	0.0141463	0.0133515	0.019251449	0.00277607	0.01111584	0.004119057	0.00635726	0.00148901	0.00590696	5.69e-05	0.00762253	0.00228469	0.00067984	0.00055893	0.00273632	0.00566334	0.00060974	0.00070358	0.00299482	4e-08	0.003253376	0.010419214	0.0204730999999999
+2:LOH:100kb-1Mb	0.004303102	0.019464869	0.033835141	0.040089381	0.255496412	0.177292158	0.0045434	0.0222829	0.013774233	0.087823539	0.01694496	0.080936481	0.02909678	0.00707926	0.0215107	0.01758306	0.00062269	0.0065518	0.054896441	0.00134094	0.06234918	0.073916265	0.00033402	0.270457816	9.09e-05	0.06078213
+2:LOH:1Mb-10Mb	0.004438013	0.033551543	0.018990581	0.00618009	0.264575824	0.116382852	0.00457336	0.00829832	0.011594393	0.131910499	0.0439202	0.132671041	0.03957572	0.02585003	0.0088679	0.01162738	0.084442329	0.00018517	0.117067141	0.01443458	0.03913487	0.079960515	0.00178993	0.2022044	0.000384815	0.17442198
+2:LOH:10Mb-40Mb	0.00431859	0.052291175	0.00267497	0.00024516	0.067065891	0.00632481	4.11e-05	0.00115938	0.004945152	0.087069829	0.02467614	0.176727892	0.01185966	0.09336807	0.00201416	0.00291477	0.088483279	0.00015695	0.04188772	0.0096627	0.00129894	0.01765472	0.00517329	0.011946964	0.000350439	0.11811706
+2:LOH:>40Mb	0.012215654	0.06737476	8.24e-05	0.00241502	0.01961649	0.00026093	0.0	0.00013197	0.002407305	0.01593395	0.01121149	0.136224511	8.5e-05	0.55221235	3.3e-07	0.00170498	0.0075038	7.26e-05	0.03389879	0.00049936	0.00195567	0.00590559	0.0	0.0050787	0.000750494	0.02060637
+3-4:LOH:0-100kb	0.001379947	0.002717402	0.0027191	0.01402566	0.005480255	0.00505183	0.00420447	0.00956472	0.001833529	0.00743812	0.00158209	0.00930253	0.00057156	0.00141835	0.00197133	0.00093853	0.00267395	0.00226406	0.01388264	0.002561	0.00053506	0.001204125	0.00072698	0.000685112	0.000296679	0.01506038
+3-4:LOH:100kb-1Mb	0.001667853	0.013819445	0.023811221	0.01144021	0.02685577	0.013510279	0.0023279	0.004662895	0.002848605	0.068455299	0.0482419	0.03071852	0.00817896	0.00688559	0.01163685	0.02159759	0.02375527	0.01402709	0.01258572	0.02182453	2.09e-05	0.00824588	0.00079858	0.011435602	8.69e-07	0.03445676
+3-4:LOH:1Mb-10Mb	0.001514284	0.012471389	0.034367671	0.00010785	0.029519046	0.00409704	0.00021573	0.00349215	0.00344351	0.096466639	0.156264722	0.04005227	0.01705423	0.00687404	0.04837325	0.043701	0.094627309	0.05963823	0.00110793	0.02055562	0.00277049	0.010814625	0.00034028	0.005760546	2.04e-05	0.09684851
+3-4:LOH:10Mb-40Mb	0.000102203	0.010631239	0.021891551	1e-07	0.00455209	5.61e-05	7.9e-07	0.002194095	0.001390007	0.04754809	0.055274161	0.02606018	0.00759605	0.00128688	0.16721937	0.0329184	0.051836149	0.07185141	0.00278047	0.0022434	0.00027444	0.00356193	0.0007486	0.00075315	1.85e-05	0.06548568
+3-4:LOH:>40Mb	0.007367609	0.017426922	0.025294791	1.3e-07	0.00073589	0.00032855	6.74e-06	0.003399115	0.001198601	0.01319828	0.03509218	0.01659015	0.00381337	7.35e-05	0.37328855	0.19071235	0.00224311	0.05059881	0.00421117	0.00094554	0.00172068	0.005440365	0.00044828	0.000533794	8.21e-05	0.02410321
+5-8:LOH:0-100kb	0.000351298	0.001689411	5.3e-07	0.025527171	0.00066453	0.00048949	0.00552275	0.010770475	0.000375937	0.00260391	0.00501223	0.00578286	0.00294361	0.00316274	0.00348453	0.0034784	0.00128554	0.00482129	2.59e-05	0.00091844	2.5e-07	0.000741885	1.4e-07	0.000227864	0.0008887	0.0070388799999999
+5-8:LOH:100kb-1Mb	0.000212107	0.003416253	0.00256956	0.00169273	0.000652505	0.00031046	0.00682636	0.009675285	0.000836165	0.02207809	0.04217432	0.00208666	0.00123595	6.47e-06	0.01942632	0.00980644	0.00726579	0.02136849	8.14e-06	0.00241053	5.46e-05	0.000521815	1.6e-06	0.000577402	0.00039106	0.00584006
+5-8:LOH:1Mb-10Mb	0.000207783	0.004495306	0.0055492	1.9e-07	0.000278185	0.00021435	6.78e-05	0.00215584	0.000661617	0.02022345	0.073571791	0.00322838	0.0061044	2.3e-07	0.02016289	0.01073875	0.01836005	0.04681185	1.58e-05	0.00524955	1.67e-05	0.001434025	1.53e-05	0.000810458	0.000206542	0.01292003
+5-8:LOH:10Mb-40Mb	9.97e-05	0.002756042	7.1e-07	1.31e-05	0.000125705	0.00011771	0.0	0.001022835	0.000376486	0.00679665	0.01532663	0.00163617	0.00077852	8.96e-06	0.01347168	0.00622641	0.00502947	0.02208834	0.00068876	0.00029923	3.6e-07	0.000605405	1.4e-07	0.00011455	1.43e-05	0.00371877
+5-8:LOH:>40Mb	0.000331938	0.010089624	0.00535955	1.4e-07	9.88e-05	0.00030406	4.93e-05	0.00145962	0.000382635	0.00017289	0.00347323	0.00110016	0.00162804	0.00572642	0.06422257	0.01067078	1.29e-06	0.00536994	0.00012041	0.00012116	3.9e-05	0.002408955	1.83e-05	8.7e-05	1.1e-07	0.00389208
+9+:LOH:0-100kb	0.000133995	0.000520196	7.1e-07	1.06e-05	0.001312595	0.00493142	0.00632901	0.022043315	0.000759424	0.00018531	0.00062013	0.00048688	4.45e-05	1.46e-06	0.00300605	0.00384194	0.00012468	0.00241473	0.00107168	0.00014531	3.6e-07	0.002498515	1.4e-07	0.00049292	0.000873954	0.0015796
+9+:LOH:100kb-1Mb	0.000411988	0.000668643	0.00216196	2.8e-07	0.00330625	0.00545954	0.02139771	0.028381515	0.001234374	0.0029966	0.01160088	0.00011188	0.00344403	8.5e-07	0.00785032	0.0047163	5.3e-05	0.01211638	0.00117826	0.00085741	3.97e-06	0.00067448	3.28e-05	0.000376804	0.001337021	0.00140594
+9+:LOH:1Mb-10Mb	0.00020077	0.000828997	0.0022066	2.8e-07	0.000649225	0.00086716	0.01464548	0.00809473	0.000574562	0.00365022	0.02224864	0.00012019	0.00163639	1.1e-05	0.00480835	2.35e-06	1.37e-05	0.01534961	1.6e-07	0.00046208	8.48e-05	0.0010781	1.4e-07	0.000121946	5.59e-05	0.00128556
+9+:LOH:10Mb-40Mb	6.51e-06	0.000350903	0.0021129	2.8e-07	1.51e-05	1.27e-05	6.1e-07	2.53e-05	1.02e-05	0.00044558	0.00252885	6.14e-05	6.1e-07	1.59e-06	0.00234481	2.35e-06	5.29e-05	0.0009794	1.6e-07	0.0001094	1.59e-05	9.02e-05	1.4e-07	5.71e-06	3.14e-05	0.00017789
+9+:LOH:>40Mb	2.76e-06	0.000712768	0.00092755	2.8e-07	1.23e-05	3.4e-05	2e-08	0.00011179	4.55e-06	9e-08	0.00148788	1.65e-05	0.00013687	1.23e-06	0.00380205	0.00333085	2.9e-07	7.7e-07	4.66e-05	1.07e-05	5.38e-05	0.00010431	1.5e-07	2.68e-06	4.97e-08	3.2e-07
+2:het:0-100kb	0.000126855	0.001077283	0.020851501	0.00018321	0.00173387	0.0035614	0.00021658	0.0010385	0.002813763	0.00213926	0.0	0.00068448	0.00242738	0.00144658	1.04e-05	0.00266672	0.00038608	0.00029759	0.0031181	0.00053199	0.00030646	0.00313745	0.00205934	0.000280432	0.059739079	0.03686276
+2:het:100kb-1Mb	0.002392692	0.001448575	0.01137198	0.0009306	0.00835966	0.00180746	0.00209292	0.0008892	0.057456734	0.00460283	1e-08	0.00313133	0.00710641	0.0003872	6.6e-05	0.00197375	0.0001888	3.02e-05	0.0312283	0.00464189	0.01868806	0.0309067	0.02112224	0.020441704	0.311415627	0.00281572
+2:het:1Mb-10Mb	0.017226427	0.000571468	0.023632351	0.00124271	0.04798882	0.008628749	0.00016457	0.002329035	0.159920321	0.0006929	0.0	0.00410482	0.06241927	0.00011283	1.17e-06	0.00185384	0.00087384	1.1e-07	0.0164266	0.00278654	0.12630567	0.161346311	0.12925873	0.196033892	0.055182533	0.00334658
+2:het:10Mb-40Mb	0.112043886	0.00040127	0.024327821	0.00653021	0.04018991	0.008931519	0.0	0.00267494	0.129543643	0.00078362	3.93e-06	0.0010782	0.06807839	1.03e-06	0.00020074	0.00136271	0.00061789	3.4e-07	0.00452687	0.0013967	0.20984675	0.108768015	0.26664244	0.179726574	0.02332703	0.00378465
+2:het:>40Mb	0.647548237	1.62e-06	0.022788761	0.047210821	6.15e-07	0.00200753	3.1e-07	0.002161405	0.006767871	6e-08	8e-08	4.3e-07	0.06958505	2.46e-06	6.46e-05	7.5e-07	0.0	3.2e-07	4.6e-07	8.15e-06	0.07227018	0.00087765	0.01902544	0.01829589	0.012052462	5.248e-05
+3-4:het:0-100kb	0.000986437	0.001301613	0.016759401	0.028397721	0.004295095	0.009499469	0.00362014	0.013551545	0.006686778	0.00557084	0.00042229	0.00495	0.00027983	0.00058958	8.1e-05	0.00179605	0.00015917	0.00117086	0.01701046	0.00077956	0.00800623	0.001840025	0.0007458	0.00050524	0.005072116	0.11355659
+3-4:het:100kb-1Mb	0.003623147	0.01521748	0.042647992	0.203288654	0.027386325	0.205503726	0.06003456	0.04139118	0.067471318	0.04177622	6.5e-06	0.00936991	0.01942203	0.00815141	5.51e-06	0.02323495	0.00188043	0.0120089	0.205701382	0.08651517	0.27819348	0.02145428	0.00157867	0.008474694	0.007390987	0.028357
+3-4:het:1Mb-10Mb	0.001734587	0.05815643	0.027620611	0.055675991	0.015401125	0.233334904	0.12143735	0.026193135	0.043510864	0.086956359	0.01763335	0.01812126	0.02082491	0.01439058	3.82e-05	0.01723295	0.185038198	0.0	0.122306121	0.33498798	0.03014244	0.044882975	0.00634558	0.015763968	0.000560018	0.00195127
+3-4:het:10Mb-40Mb	0.003009542	0.135200883	0.018505441	0.00340995	0.02038458	0.062990656	0.00493032	0.00495607	0.007530375	0.067579949	0.00761337	0.100679891	0.01275603	0.03273598	0.00189743	0.00618312	0.188270228	0.00227849	0.075935951	0.16201175	0.0061488	0.020714495	0.00077023	0.009131138	6.73e-05	0.00989549
+3-4:het:>40Mb	0.005373925	0.390284779	1.8e-07	0.00472731	0.002974155	0.00240527	0.00022509	0.02416852	0.002876185	1e-08	6.2e-05	0.00090365	0.00958487	0.16670478	0.00450937	0.00048235	0.000536	0.02652536	0.00256084	0.00119273	2.8e-07	0.00051959	2.1e-07	0.001866582	1.05e-07	0.00309533
+5-8:het:0-100kb	0.000741212	0.001717201	0.00551728	0.068606241	0.003368305	0.00362532	0.01467759	0.032617975	0.001719672	0.00596208	2.95e-05	0.00044794	0.00098094	0.0014848	0.00286475	0.01032126	0.00049621	0.00230818	0.00185133	0.015153	0.00031093	0.00058946	3.53e-05	0.002082402	0.000307891	0.02211369
+5-8:het:100kb-1Mb	0.00011638	0.011630412	0.039523742	0.056865761	0.007209015	0.00454924	0.16196039	0.127337371	0.00135021	0.04005666	0.0438027	0.00783497	0.00090333	0.00011311	0.00878768	0.04438502	0.0124036	0.02222437	0.02780896	0.14454268	0.00022234	0.00175159	0.00091931	0.004128916	0.000567382	0.00622323
+5-8:het:1Mb-10Mb	0.000204002	0.019335548	0.162603387	0.01134511	0.008309545	0.00205142	0.21136197	0.061241481	0.001136105	0.01210908	0.185368842	0.00156351	5.8e-07	3.2e-07	0.00632529	0.08961901	0.129027959	0.14409608	0.02161426	0.10976846	9.72e-06	0.004135055	0.00226165	0.005086422	7.9e-06	2.523e-05
+5-8:het:10Mb-40Mb	1.93e-05	0.025641671	0.122266015	0.00463152	0.00097313	0.00026427	0.0048432	0.008361195	0.000468092	0.00183866	0.057285501	0.00131279	0.00020304	0.00011361	0.0281915	0.08336645	0.055166629	0.18136026	0.00344696	0.01800115	0.00012714	0.001374835	0.00179573	0.002817716	2.11e-08	0.00612999
+5-8:het:>40Mb	0.000525662	0.044174807	0.076936563	1e-08	0.00127684	2.19e-05	0.00032996	0.004528565	0.000413552	0.0	0.01649539	0.00069671	6.82e-05	0.00174446	0.07821007	0.25307107	1e-08	0.09531375	2.3e-07	0.00182344	0.00247148	0.00133954	1.8e-07	0.000780186	9.32e-08	0.00164991
+9+:het:0-100kb	0.000105258	0.000991451	0.00254618	5.16e-05	0.003029025	0.016700899	0.02554054	0.094947456	0.00168183	0.00047103	1e-08	2.48e-05	0.00089424	8.2e-07	0.01505965	0.00338768	5.39e-05	0.0093412	0.00503956	0.0035707	5.99e-05	0.000483875	1.41e-05	0.000621376	0.00193162	7.706999999999999e-05
+9+:het:100kb-1Mb	0.000318177	0.00324101	0.00174383	2.15e-05	0.00738562	0.043428957	0.16018674	0.266746762	0.004252061	0.0002512	8.13e-06	0.00018166	0.00050042	0.00012566	0.00017234	0.0033166	7.49e-05	0.05049958	0.00484797	0.00971177	0.00011614	0.00014049	1.5e-07	0.001350168	0.00202686	3.57e-06
+9+:het:1Mb-10Mb	0.000187035	0.003779865	7.1e-07	2.6e-07	0.00611754	0.00489714	0.14906452	0.110528846	0.000808817	1e-08	0.052794321	0.00016027	0.0027117	9.5e-07	0.00554372	0.00998959	0.00013899	0.08409049	0.01332158	0.00568101	3.6e-07	0.00027061	1.4e-07	0.001385586	0.00173436	2.515e-05
+9+:het:10Mb-40Mb	1.74e-06	0.001908404	0.00197462	2.4e-07	6.79e-05	3.36e-05	0.00053612	0.001809925	3.12e-05	0.00012153	0.00605752	0.00013193	4.29e-05	1.06e-06	0.01155315	0.00316669	0.00012341	0.01848061	1.56e-05	0.00085042	0.00015659	0.000242765	1.4e-07	0.000133182	6.72e-06	0.00012162
+9+:het:>40Mb	1.18e-05	0.00209996	0.00203108	1.47e-05	9.3e-05	2.36e-05	2.25e-05	0.001085855	2.93e-05	0.00030777	0.0003921	3.55e-05	9.77e-05	1.27e-06	0.00768259	0.0067409	1e-08	0.00241512	2.72e-05	3.53e-05	2.31e-05	2.85e-05	1.4e-07	2.28e-05	4.97e-08	4.631e-05

sigprofilerassignment-1.1.0/SigProfilerAssignment/data/Reference_Signatures/GRCh37/COSMIC_v3.5_DBS_GRCh37.txt

@@ -0,0 +1,79 @@
+Type	DBS1	DBS2	DBS3	DBS4	DBS5	DBS6	DBS7	DBS8	DBS9	DBS10	DBS11	DBS12	DBS13	DBS14	DBS15	DBS16	DBS17	DBS18	DBS19	DBS20	DBS21	DBS22
+AC>CA	4.97e-05	0.000374079	0.006347323	0.004141857	0.002139822	0.002660571	0.045880132	0.214923552	0.024591818	0.009630417	0.001369907	0.005055938	0.002155121	0.01993572	0.015497544	0.056543602	0.020714155	0.010322835	0.005019088	0.00503114	0.0307173617513781	0.0146332114459876
+AC>CG	2.64e-05	3.17e-05	4.65e-05	4.96e-05	0.000461962	0.000146031	0.006247295	0.000972654	0.002069312	1.77e-05	0.000193987	0.002412014	5.15e-05	0.000470977	1.23e-05	0.004274165	0.001784735	0.002708308	0.000614834	0.00190918	8.409565388888336e-05	0.0019117573810107
+AC>CT	0.004291091	0.000126027	0.003018727	8.32e-18	0.002019832	0.000240052	0.013594113	0.317886928	0.028490521	0.013500585	0.000755948	0.000465784	0.002853398	0.001475449	0.015137074	0.013859778	0.014488098	0.020157714	0.016252019	0.00237222	5.975532014842494e-08	0.0019032535142969
+AC>GA	0.000127032	0.00023705	0.005847534	0.004401974	0.000557954	0.008581841	0.009725788	0.001159588	0.025291585	0.005350232	0.00044197	0.007284703	0.002762299	0.000788733	0.016256457	0.008476822	0.019191793	0.007339722	0.003369214	0.00158594	0.0066587843046396	0.0086713197689134
+AC>GG	5.71e-05	4.17e-18	0.00044981	7.01e-18	1.11e-17	0.000104022	0.002538901	0.000809712	0.007127629	0.000590026	0.002249847	0.007540177	0.001464314	0.000265703	0.001741257	0.003519902	0.008064512	0.004986928	0.000779431	0.00263499	0.0018152869523489	0.0010654974388171
+AC>GT	0.002960753	0.000280059	0.010095742	1.12e-08	0.000821932	0.000132028	0.004498052	0.000150946	0.012095976	0.028701244	0.005709611	0.002008084	0.004439439	0.003216438	0.09285221	0.003577356	0.030542486	0.012220562	0.011904767	0.0003164	0.0241778490657548	0.0024897899418957
+AC>TA	0.001200305	0.001480313	0.001009574	0.00127057	0.001479877	0.010102168	0.005417654	0.012395591	0.041186297	0.000105005	0.000263982	0.007159833	0.002579913	0.001595998	0.002551332	0.005687769	0.008662643	0.022936838	0.006233218	0.00933111	0.0057468284861944	0.012742879001256
+AC>TG	0.000172044	6.36e-06	1.11e-17	5.31e-05	0.001119907	0.000449096	0.000997568	0.002569086	0.017894047	7.66e-06	0.000238984	0.001606502	0.004284486	7.73e-05	0.000369916	0.001091719	0.008804955	0.01387712	0.001016945	0.0001306	0.0004137358774876	0.0020984818607282
+AC>TT	0.026506737	0.002920618	1.78e-06	0.000161072	0.007469379	0.003180682	0.001179489	0.000267905	0.044385233	0.000710031	0.002819808	0.003363148	0.015739739	0.000762895	0.006943356	0.004182681	0.017468062	0.016842745	0.066818468	0.00251075	0.0050595327530672	0.0097158129574373
+AT>CA	0.000482123	3.78e-05	0.007037032	0.000916411	0.000107991	0.000114024	0.011095195	2.78e-05	0.012695776	0.003530153	0.009479354	0.001949476	0.004208115	0.002339905	0.001157098	0.007864558	0.010150171	0.004560274	0.004322273	0.0022381	0.0056221165538405	0.0051931184813781
+AT>CC	0.000297076	4.17e-18	0.009076172	7e-18	2.13e-05	6.39e-05	0.00625729	0.000142949	0.001779408	0.00116005	0.00189987	0.003491967	0.001008029	0.00037024	0.010013439	0.002090492	0.007050836	0.001818777	0.002047984	0.00123446	0.0003929255149778	0.0009965692749409
+AT>CG	3.98e-06	4.17e-18	0.014593845	9.46e-18	1.05e-17	1.82e-06	0.00110952	0.000265905	9.22e-18	0.002590112	1.74e-05	0.001357392	2.33e-06	4.37e-08	3e-07	0.003649763	0.001416492	0.000742811	0.000297899	0.00155349	3.588725020094043e-07	0.0001481920568702
+AT>GA	0.002120539	0.000168036	0.001809237	0.000324145	0.001109908	0.001620348	0.014393767	0.000161942	0.006367881	8.06e-05	0.011199236	0.006419643	0.00213368	0.0042037	0.007839901	0.004752044	0.014212182	0.002640487	0.010191431	0.00845878	0.010716311719864	0.0028069967738517
+AT>GC	0.000174044	5.85e-06	0.005247787	1.76e-05	1.05e-17	1.72e-05	0.009285979	0.00022592	0.001809398	0.004080177	0.004179715	0.004039874	0.000300299	0.000472354	0.014691143	0.001510302	0.010928285	0.000494586	0.002339553	0.00036851	0.0030102823589385	1.887867147599397e-05
+AT>TA	0.002340595	0.000458097	0.002349009	0.004532032	0.000792934	0.002200472	0.033985283	0.000314888	0.00919694	0.002930127	0.003839738	0.002697639	0.010517294	0.009285173	0.012340007	0.006543192	0.012537799	0.008000102	0.012281658	0.00293144	0.0826480680583893	0.007731031525148
+CC>AA	1.06e-05	0.724153238	0.009086168	7e-18	1.05e-17	8.3e-18	9.04e-18	0.038086453	9.02e-18	0.013700594	7.35e-18	0.016391962	5.13e-07	0.002647122	0.017028409	0.034187122	0.000352387	0.010610342	0.020589808	0.00037896	0.0043832976582385	6.021724812266276e-08
+CC>AG	1.23e-05	0.072615366	1.11e-17	0.005432436	0.024297979	0.06161322	8.3e-05	0.015494489	0.02639122	7.13e-05	0.000971934	0.019745976	0.011679584	0.000109879	8.94e-06	0.010690711	0.001213603	0.047633472	0.006289116	0.00397481	0.0019352239253054	0.0249109020361676
+CC>AT	0.018704754	0.100021165	0.005887517	0.015707044	0.002429798	0.000438094	0.000851631	0.028789759	0.019493515	0.010500455	0.034497648	0.014912009	0.043281394	0.000480437	0.029213271	0.018390883	0.000730958	0.099232424	0.084441241	0.00553983	0.0020035799500996	0.0396550952390015
+CC>GA	0.000134034	0.017703746	0.000634732	0.003551593	6.76e-05	0.035507619	0.000301869	0.000808712	0.010996342	0.003390147	0.000952935	0.012598378	1.04e-05	0.0	8.93e-06	0.002978183	0.000748926	0.015979632	0.003858778	0.00085171	0.0010591391830049	0.0129777302653636
+CC>GG	9.82e-05	0.000450095	7.25e-05	7.3e-05	1.19e-05	0.018103885	0.002049113	5.6e-05	0.003058982	7.41e-18	0.003449765	0.02162396	0.000769436	0.001799943	5.91e-07	0.000175355	0.003299617	0.005213375	0.00106943	0.00268544	0.0027364463467291	0.0009426809469442
+CC>GT	0.006921759	0.001100233	1.14e-17	7.99e-05	2.48e-05	0.003440738	0.000162929	0.000228919	0.017894047	0.001080047	0.069495262	0.007396935	0.02345453	0.000419574	0.000519642	0.002714998	0.009460629	0.019021139	0.012067483	0.00415748	0.0043268166216932	0.0162735507258212
+CC>TA	0.010402644	0.016003386	0.020791232	0.000170076	0.001269894	0.002220476	9.04e-18	0.000715745	0.000686772	0.023901036	0.058795991	0.010815781	0.04135706	0.0	0.051623875	0.007067731	0.000290776	0.022670451	0.036277155	0.00994449	0.0006274783706657	0.0092132690713914
+CC>TG	0.002550648	0.00023705	2.9e-05	8.3e-06	0.0048096	0.006871474	0.000235898	0.004208503	0.015494845	7.41e-18	0.032297798	0.028898566	0.009544726	0.000471886	2.84e-05	0.000419159	0.031639508	0.018068499	0.005603413	0.00199377	0.0068363608820325	0.0053430463172998
+CC>TT	0.858218125	4.17e-18	1.11e-17	7e-18	1.05e-17	8.3e-18	9.04e-18	0.004378443	9.02e-18	0.020600893	0.331977366	0.001413473	9.97e-05	0.005388226	0.086708012	0.016212038	0.000822735	0.032041353	0.077856007	0.00585993	0.0085623355396139	1.1039828822488177e-07
+CG>AT	6.03e-07	0.001150243	0.00028388	0.00029013	0.001639864	0.007541618	6.21e-05	0.000321886	0.000218927	7.41e-18	0.001819876	0.030050354	0.000412789	6.44e-09	0.000185398	0.000129961	0.002510979	0.000826621	0.000254009	0.0014601	0.0007337373734601	0.0004151640472892
+CG>GC	5.42e-06	0.000369078	1.11e-17	5.1e-06	9.92e-05	0.000590127	0.000186919	1.13e-17	1.2e-05	1.9e-05	0.000165989	0.085833786	0.001170693	0.001209911	2.76e-06	0.000188346	0.002335362	3.22e-05	4.54e-05	0.00015095	0.0001876203288585	0.0002716968325788
+CG>GT	1.7e-06	0.001280271	1.11e-17	7e-18	0.006479461	0.003220691	2.07e-05	0.00120957	9.94e-05	1.02e-05	0.00117992	0.096299804	0.00236357	0.000159847	0.000228167	0.001451902	0.00476132	0.001612797	9.18e-05	0.00024229	0.000176758310247	0.00045890159378
+CG>TA	0.000356091	4.17e-18	0.097858731	7e-18	1.05e-17	8.3e-18	9.04e-18	0.00050582	9.02e-18	0.358015516	7.38e-18	0.030507175	0.000655573	6.27e-08	8.7e-05	0.001760233	0.005848084	0.000254724	0.001895043	0.0005112	2.304671845624203e-07	0.0009471496703667
+CG>TC	1.26e-05	0.002150455	0.000721696	7e-18	2.98e-05	0.008911912	4.87e-05	0.000904678	0.000132956	0.002650115	0.000684953	0.119573465	0.00221426	0.000198283	0.000617251	0.001206429	0.005637013	0.001207225	0.000296905	0.00127668	0.0023792430102987	2.2191262067454985e-05
+CG>TT	0.000124032	0.005561177	0.007166978	0.000361162	0.002219815	0.018704013	3.13e-05	0.000328883	8.29e-05	0.007770337	0.000698952	0.110196291	0.00164313	0.000106432	0.002673117	0.003571947	0.012321918	0.00254547	0.001626719	0.00039108	0.0039944672631482	0.0028861943351601
+CT>AA	2.77e-05	0.003210679	0.000102957	7e-18	0.465961237	0.004480961	9.04e-18	0.020592675	9.02e-18	0.00393017	0.0043997	0.008059373	0.061689865	0.000213356	0.003747327	0.06121544	0.01041216	0.026536827	0.010148639	0.00960691	0.0027882020191485	0.0574783215429853
+CT>AC	0.000419107	4.17e-18	0.029087733	7e-18	0.208982615	0.001950419	1.01e-17	0.013995022	9.02e-18	0.013000563	0.00234984	0.007940884	0.025896885	0.008975521	0.076431379	0.08305172	0.014599085	0.026147565	0.006679462	0.00569839	0.0241639832857511	0.0315617895364936
+CT>AG	2.85e-18	0.000587124	0.113951944	0.000363163	0.026697779	0.039508477	0.001259455	0.020392746	0.000581806	0.026501149	0.000495966	0.004231297	0.013288341	0.0	2.94e-06	0.033156692	0.008127513	0.007266997	0.002646422	0.00057029	0.0014012204415147	0.0121170135998203
+CT>GA	8.92e-05	1.81e-05	1.72e-05	0.000673302	0.016098661	0.007341575	0.001869191	0.005568019	0.002839055	7.41e-18	0.011599209	0.001974625	0.001094087	0.000202334	0.000281927	0.001115376	0.005520223	0.003647363	0.003176448	0.00312897	0.0018730632373286	0.0054035053233884
+CT>GC	0.000252064	0.000134028	2.69e-05	7.22e-05	0.004849597	0.001790384	0.015593248	0.000236916	0.003108966	7.41e-18	0.006109583	0.000889745	0.003880389	0.00439828	0.000332526	0.008867382	0.011094593	0.001224537	0.003364375	0.00063377	0.0019889493679607	0.0048914150733956
+CT>GG	1.08e-05	8.98e-05	5.99e-05	0.000926415	0.000569953	0.006811462	0.003998269	0.000305891	0.010396541	7.41e-18	0.004019726	0.011406077	0.002649986	9.47e-05	0.000242249	0.004112066	0.007749222	0.001985281	0.001009744	0.00050315	0.0022435794448278	0.0045564598033311
+CT>TA	0.007811985	0.003380715	0.000183922	7e-18	0.003339722	8.84e-05	9.04e-18	0.010896124	9.02e-18	0.004030175	0.041697157	0.010594002	0.031085796	0.001389264	0.003422208	0.017791431	0.000912168	0.009521994	0.071396106	0.01808698	0.0102011736008668	0.0148420842527412
+CT>TC	0.010502669	3.84e-05	0.006337327	7e-18	0.00023698	8.3e-18	0.063172644	0.017793671	3e-05	0.002750119	0.002989796	0.009083663	0.008510987	0.027589692	0.066518088	0.092975607	0.018732976	0.006320824	0.045766787	0.00065994	0.0510843930852715	0.0043124863594548
+CT>TG	0.002240569	0.000390083	0.052177995	3.08e-05	0.000873927	0.011202404	9.04e-18	0.000965657	9.46e-18	0.045701981	0.001479899	0.003177719	0.003913486	0.000371732	7.22e-06	0.006479737	0.024440751	0.002596032	0.013528268	0.00600496	0.0005903704635977	0.0050264873972797
+GC>AA	0.001580402	0.005081075	2.16e-05	0.328147163	0.000132989	8.3e-18	9.04e-18	0.012895413	9.02e-18	0.004080177	0.000999932	0.026554392	3.19e-08	0.000208559	0.043811196	0.015656868	0.125929493	0.034834999	0.01319082	0.01018321	0.015102110942301	4.152667812666687e-07
+GC>AG	0.000107027	0.000325069	0.00052178	0.01130507	0.002659779	0.003660785	7.3e-05	0.008516971	0.123958759	7.41e-18	0.003289776	0.010307466	0.016969154	0.000477128	0.003924086	0.0075527	0.018904026	0.042296529	0.003964108	0.00971442	0.0035651204798674	0.030611968103183
+GC>AT	4.87e-05	0.000953202	0.003988318	0.009244146	0.001569869	0.001880403	0.000349849	0.005508041	0.125958094	0.007750336	0.027198146	0.006964502	0.017372386	2.47e-07	0.145018301	0.004065	0.046250688	0.050690401	0.003925252	0.01683102	0.0052159609236478	0.0130791919004845
+GC>CA	5.76e-05	0.001060224	0.0002369	0.011905339	0.004579619	0.008691865	0.00066971	0.004828283	0.027390887	0.000105005	0.002109856	0.005267102	0.010399208	0.000156319	0.001191386	0.003761259	0.011349393	0.023420801	0.001043018	0.00996847	0.002997545573227	0.0062416420346834
+GC>CG	5.15e-06	6.69e-05	1.11e-17	9.83e-07	0.000322973	9.04e-18	0.002648853	0.000241914	0.002499169	7.41e-18	0.004039725	0.00101238	0.000864869	0.000572407	0.000351655	0.001254815	0.00036973	0.00193531	0.000184208	0.00098246	8.993140254969854e-06	0.0001913772154154
+GC>TA	8.27e-07	0.000736156	0.004228217	0.017707941	0.000221982	0.000829178	6.24e-06	0.008556956	0.013995344	0.002810122	0.000242983	0.000770159	3.39e-05	6.34e-06	0.001700454	0.000666802	0.008755137	0.019024828	0.000915514	0.00031415	0.0019503130213415	0.0002392037944676
+TA>AT	0.000505128	0.002750582	0.001449389	0.030413639	0.001869844	0.008571839	0.055775847	0.009696551	0.015494845	0.010400451	0.002229848	0.008196571	0.006245895	0.010463586	0.025317628	0.008410253	0.008762457	0.010450043	0.009849565	0.16094933	0.1109733668172908	0.0081801580119266
+TA>CG	7.55e-06	1.89e-05	0.003338592	0.000389175	7.89e-06	0.000259056	0.00304868	2.09e-05	0.001349551	0.004110178	0.00058396	0.00054599	0.000244713	0.00014673	0.015331004	0.001250772	0.007286582	0.001925745	0.000585235	0.00644311	0.0013788709636844	7.142588637786701e-05
+TA>CT	0.000702178	0.000280059	0.000343855	0.008723912	0.002269811	0.026105602	0.029087404	0.004098542	0.014195277	0.00162007	0.00337977	0.003157555	0.016384837	0.003276151	0.00256413	0.010859844	0.016921233	0.011142003	0.009324654	0.11690854	0.0131424321645909	0.0138455009103347
+TA>GC	2.01e-05	8.22e-05	0.001989161	7.02e-05	5.22e-05	0.000264057	0.001509346	0.000788719	0.000578807	7.41e-18	0.00101993	0.001798997	0.000126772	8.18e-05	7.97e-05	0.000900104	0.00070131	0.000262405	0.00025387	0.00286647	0.000631217890745	0.0007065485482902
+TA>GG	7.03e-05	7.89e-05	0.005457698	0.002220996	0.001629864	0.000218047	0.004308134	0.000216923	0.003248919	0.008590372	0.000374974	0.002579796	0.00059345	0.000358303	0.002323631	0.00093403	0.005882048	0.003743955	0.001149146	0.00980494	0.0021094192527044	0.002591030989423
+TA>GT	0.001150292	0.001300275	0.000361847	0.008063616	0.001909841	6.25e-05	0.026288616	0.000152946	0.007777412	0.003610156	0.002669818	0.001542158	0.006147368	0.003566001	0.000822818	0.005843986	0.012383849	0.007031086	0.007717736	0.05618043	0.0094141965837011	0.0070207330206814
+TC>AA	1.09e-05	0.001450307	0.005487686	0.379170045	0.040396639	0.045809829	0.019591516	0.038786204	0.003688773	0.007560328	0.000216985	0.02219116	0.068108944	0.000633091	0.000486878	0.072475827	0.058157842	0.003674987	0.013038923	0.18018691	0.0190801245980388	0.1525726633645017
+TC>AG	3.09e-06	0.000200042	6.14e-06	0.001870839	0.014898761	0.008281777	4e-06	0.011595875	0.046684468	0.000271012	0.047396768	0.007778106	0.067216661	5.73e-09	0.000115018	0.009803143	0.000232577	0.011850575	0.002819328	0.00799556	0.0061613388206616	0.0392522935655481
+TC>AT	0.002460625	4.17e-18	0.001119528	0.008413773	0.000747938	0.000594127	0.002289009	0.018493422	0.051782772	0.003090134	0.084594232	0.019078044	0.157912393	0.001992905	0.008164433	0.025369037	0.001311999	0.073564885	0.089890485	0.0239577	0.0369717918719218	0.1336073675417147
+TC>CA	4.42e-06	0.000682144	0.065472389	0.084637957	0.001429881	0.011802532	0.002708827	0.017593742	0.04878377	0.025201092	0.000281981	0.023730105	0.037507986	0.00474929	0.020503712	0.014005863	0.005348827	0.01880728	0.004528278	0.01512029	0.0225578876784587	0.0547540793038425
+TC>CG	3.3e-05	3.89e-06	0.000115951	0.000400179	1.06e-17	0.000862185	0.001629294	0.010896124	0.007787409	0.000842036	0.003239779	0.006832254	0.007226905	0.000758988	3.4e-06	0.000258731	0.001641628	0.002192277	0.000635175	0.00047311	0.0026132042366973	0.0048943030525639
+TC>CT	0.001900483	0.003350709	0.019391822	8.28e-06	0.001049913	0.009392015	0.009186022	0.008756885	0.051382905	0.026201136	0.02009863	0.006225306	0.032501655	0.029846272	0.048024505	0.007547601	0.020706331	0.025513035	0.018195221	0.01822673	0.0643766611070659	0.0248330333186565
+TC>GA	6.42e-05	0.000885187	0.077767204	0.036416331	2.46e-05	0.007341575	9.04e-18	0.009606583	0.017294246	0.043801898	0.000234984	0.012496645	0.011584332	0.0	2.35e-06	0.004011448	0.006224147	0.001900806	0.003204044	0.00704212	0.0053475808991824	0.0267525258475157
+TC>GG	0.000411104	9.87e-06	0.000176925	1.04e-05	3.48e-05	0.001510324	0.000705694	0.001909321	0.003728759	7.41e-18	0.0073295	0.00170472	0.015384381	9.47e-05	1.15e-09	0.002238811	0.00028347	0.001838723	0.001200299	0.00095776	0.0005000583975486	0.0051012128783676
+TC>GT	0.005101297	8.57e-05	0.043381705	7e-18	3.86e-05	8.3e-18	9.04e-18	0.000275902	9.15e-18	0.045901989	0.015198964	0.001367407	0.033311728	0.000523876	0.000147695	0.004264773	0.000388565	0.008122282	0.025897391	0.00543547	0.005103975179268	0.0188119493997444
+TG>AA	0.001370348	0.002960626	6.68e-05	0.007633423	0.017998503	0.025505473	0.022590218	0.008646924	0.015794745	0.001420062	0.007829466	0.002809632	0.019240879	0.000412255	0.003557839	0.007169951	0.008244438	0.010047845	0.009196022	0.02281667	0.0016556786944816	0.0175001458102004
+TG>AC	0.00023706	0.000220047	8.04e-05	0.000118053	0.001459879	0.010102168	0.002618866	0.003848631	0.007267582	0.000207009	0.000865941	0.000920679	0.004423546	2.78e-05	0.000159038	0.000798883	0.002321386	0.004515355	0.001923671	0.00386415	0.0012906567316382	0.0044697696860336
+TG>AT	0.002410613	0.004290908	0.000957596	7e-18	0.020398303	0.22104743	0.001289442	0.008217077	0.000745752	0.002500108	0.010499284	0.019556754	0.018519707	0.001017406	0.0018636	0.008949356	0.009103068	0.026969591	0.015606709	0.04884615	0.0154890548063693	0.0094361243818459
+TG>CA	0.000279071	0.00014403	0.015893297	0.000804361	0.00047596	0.011402447	0.023889655	0.005058201	0.022792417	0.029201266	0.056096175	0.015597346	0.028637802	0.005926623	0.078812759	0.005452183	0.145545155	0.015736824	0.007013561	0.00243813	0.0660663964296547	0.0049621160723901
+TG>CC	0.000103026	5.94e-05	0.000483796	0.000120054	0.000505958	0.007891693	0.001049546	0.001249556	0.011796075	0.000190008	0.003129787	0.022780717	0.005206514	0.000433533	0.000194374	0.002423519	0.017292738	0.003782541	0.001872952	0.00013112	0.0033627235661574	0.0041707348036057
+TG>CT	0.00185047	0.00307065	0.006067441	8.21e-05	0.000327973	0.27505902	9.04e-18	0.019493066	0.000967678	0.004330188	0.00557962	0.018261631	0.016504787	0.000426796	0.003678294	0.009846344	0.0037354	0.010574651	0.016813086	0.01212043	0.0027407503043468	0.0320401177581025
+TG>GA	0.000407103	0.001470311	0.00052278	0.007853522	0.003269728	0.007441597	0.008246429	0.000270904	0.006177945	2.02e-05	0.007309502	0.002296312	0.006105121	0.003540887	0.005464154	0.001188845	0.009965739	0.00077124	0.00328371	0.0191511	0.007444744198112	0.001947112588539
+TG>GC	8.89e-05	0.000272058	0.00049779	0.000604271	0.000291976	0.005601202	0.003878321	0.003538741	0.0039087	7.41e-18	0.006119583	0.001950142	0.002194356	0.003046221	0.000649841	0.00140568	0.00747641	0.000830959	0.001364974	0.00051919	0.0019729067323442	0.0017318409784998
+TG>GT	0.001900483	0.006401355	0.010295658	3.23e-05	0.082693121	0.027405881	0.00870623	0.007857205	0.003338889	0.002170094	0.005239643	0.005554744	0.019161828	0.032619614	0.005781918	0.028982983	0.003237668	0.003101985	0.009557295	0.00525343	0.1275717994326657	0.0159961308406375
+TT>AA	0.005491396	0.004310912	0.003218643	1.8e-05	0.004919591	0.000193041	0.23489828	0.003578727	0.000340887	0.014500628	0.004769675	0.004289044	0.013185494	0.193877621	0.008262647	0.033515238	0.000211844	0.027232862	0.052897039	0.062662	0.0513356893610371	0.0134147687780586
+TT>AC	0.000720183	0.000345073	0.002428976	6.6e-07	0.00096592	0.000128027	0.039982686	1.13e-17	0.006657785	7.41e-18	0.001039929	0.000410836	0.00147249	0.012421524	0.003723603	0.008655384	0.011976581	0.017467985	0.009625463	0.01054644	0.0010098484615043	0.0026004694096176
+TT>AG	0.000418106	0.000215046	0.022890347	7e-18	0.000892926	0.002120455	0.053876669	0.014594809	0.000917695	0.006960302	0.001269913	0.003053703	0.005792166	0.006800535	0.000263724	0.030637872	0.006402165	0.008045275	0.009413469	0.01556096	0.0028962333515717	0.0033505874932859
+TT>CA	0.000725184	4.17e-18	0.000693707	7e-18	1.05e-17	8.3e-18	0.09765771	0.006287763	9.03e-18	0.001290056	0.002019862	0.003296511	0.00380848	0.007467717	0.002669611	0.089474486	0.013897479	0.016968792	0.022062368	0.00064064	0.0004317268976505	0.0062201107668431
+TT>CC	0.005421378	2.98e-06	0.00815656	7e-18	0.000772936	8.3e-18	0.035384677	0.000293895	0.005158284	0.002880125	0.003999727	1.88e-07	1.05e-06	0.374297513	0.013720759	1.92e-06	3.8e-06	2.12e-07	0.033990285	0.00275531	0.0105498253990228	0.0037114919314741
+TT>CG	8.38e-05	1.52e-05	0.031786595	7.25e-18	1.05e-17	1.12e-05	0.002668844	0.000115959	1.98e-05	0.008580372	9.96e-18	0.001672661	0.000856761	3.36e-05	0.002697436	0.011152748	0.0063733	0.003825314	0.003706624	0.00098567	0.0017379372567984	0.0009245177800736
+TT>GA	0.001860473	4.79e-05	0.012294815	7e-18	2.99e-05	8.3e-18	0.043581128	0.003628709	9.17e-18	0.008690377	0.000706952	0.000442363	0.002826837	0.015890093	0.000797128	0.008136742	0.008662665	0.001357204	0.016435813	0.00134789	0.0617455809019753	0.0046667379036601
+TT>GC	0.001060269	1.54e-06	0.066471967	7e-18	5.66e-05	4.09e-07	0.003668411	0.000285898	3.56e-05	0.025801118	5.78e-06	0.006538126	0.000755107	0.006386925	0.010482114	0.013267588	0.018174357	0.00270108	0.009665843	0.00271044	0.0001547474243629	0.0014433545995926
+TT>GG	0.001610409	4.17e-18	0.170927916	7e-18	1.05e-17	8.3e-18	9.04e-18	0.000537809	9.02e-18	0.084703671	7.34e-18	2.94e-07	2.32e-06	0.175973553	1.43e-05	0.000274018	4.75e-06	3.96e-07	0.010591496	0.00018887	2.61652665242731e-07	0.0014211485213665

sigprofilerassignment-1.1.0/SigProfilerAssignment/data/Reference_Signatures/GRCh37/COSMIC_v3.5_ID_GRCh37.txt

@@ -0,0 +1,84 @@
+Type	ID1	ID2	ID3	ID4	ID5	ID6	ID7	ID8	ID9	ID10	ID11	ID12	ID13	ID14	ID15	ID16	ID17	ID18	ID19	ID20	ID21	ID22	ID23	ID24	ID25
+1:Del:C:0	0.000159889	0.004824116	0.124727109	0.007249717	0.022202108	0.030506799	0.000466561	0.039827558	0.33493988	0.025105414	0.001576565	0.052787741	0.065548371	0.012016009	0.026527369	0.000952769	0.006117599	0.006012048	0.054089076	0.006578444	0.00138887	0.002569923	0.05169788	0.02271784	0.03316423
+1:Del:C:1	0.000773523	2.21e-05	0.20887617	0.002734869	0.028547215	0.005491903	1e-18	0.023915938	0.099994226	0.02930632	0.000550318	0.014674665	0.017536463	0.001946232	0.121009787	2.64e-18	0.003667555	0.002004016	0.015008861	0.003268685	0.004836623	0.001730933	0.1061941	0.0076713	0.01537897
+1:Del:C:2	3.31e-18	3.11e-06	0.176324218	0.002041063	0.026596927	0.008033994	0.008561945	0.003330554	0.002690655	0.018804056	0.000357338	0.000561932	0.005120219	0.000683696	0.147828864	8.15e-05	0.001220327	0.002004016	0.001849447	0.002094676	0.001284341	0.000798746	0.05287559	0.00051143	0.01384408
+1:Del:C:3	0.001907613	0.002472076	0.064042764	0.001112283	0.014159122	0.001102379	0.042360147	0.005403153	0.010625416	0.01650356	9.08e-18	0.000995577	0.005350516	0.000487468	0.136006058	0.001624914	2.26e-08	0.004008032	0.006563183	0.002189543	0.002792894	0.001532915	0.03862287	0.00155911	0.00689178
+1:Del:C:4	0.00070599	0.003856976	0.043989808	0.001075684	0.002873422	0.00247817	0.114891908	0.001275709	0.012496902	0.002930632	9.08e-18	0.00224005	0.004346005	0.002071921	0.084197696	0.003378643	1.94e-08	1e-18	0.008206888	0.000481952	0.005253476	0.002421533	0.01125206	0.0015892	0.00438559
+1:Del:C:5	0.003370115	0.014615424	0.022417486	0.002246178	0.002602449	0.001322073	0.25176314	0.000933729	4.48e-05	8.42e-18	0.000156465	0.029410808	0.000843056	0.002370276	0.018458293	2.65e-18	0.001220933	0.002004016	0.000336114	2.24e-09	0.014248202	0.005329239	0.00573968	0.00216127	0.00642889
+1:Del:T:0	0.001311605	0.007905966	0.03759923	0.006635052	0.101481148	0.004284162	0.00266749	0.034243687	0.105105373	0.028306105	0.000944206	0.045135118	0.053698762	0.018309803	0.023951637	0.00062865	0.006088347	0.08617269	0.018543991	0.004058988	0.062891728	0.00318728	0.21323872	0.00332893	0.26254261
+1:Del:T:1	3.31e-18	3.95e-18	0.013309824	0.001622466	0.10609961	0.000677688	0.007732725	0.010452076	0.044293641	8.42e-18	0.000258505	1.42e-17	0.498224165	0.000852559	0.07996011	0.00015704	0.004903196	0.17234538	0.00460977	0.00339319	0.005917236	0.002365559	0.11431327	0.01282081	0.01134398
+1:Del:T:2	0.000936453	0.007036418	0.016501851	0.002633405	0.114128463	0.011659665	0.00025476	0.00899203	0.085861956	0.001510326	0.000516519	0.010969204	0.023777805	0.010856423	0.120410466	2.66e-18	0.001225482	0.118236947	0.008737993	0.003778359	0.005145233	0.001846387	0.05769072	0.01728524	0.015324
+1:Del:T:3	0.002295855	0.020234743	0.020141477	0.000306038	0.088962207	0.022242391	0.028972742	0.009825045	0.113250663	0.001420306	0.00042568	0.022109366	0.062780952	0.01718395	0.113431215	2.66e-18	0.00122381	0.23847791	0.022644132	0.005646206	3.08e-05	0.000102636	0.03864648	0.00886542	0.01790305
+1:Del:T:4	0.004291422	0.047119925	0.015814364	0.001023202	0.052259532	0.017697141	0.158850552	0.00127378	0.094412737	0.00241052	0.001932451	0.044077964	0.023004382	0.013347903	0.079178832	0.001001651	1.34e-09	0.090180723	0.020523528	0.002665711	0.000336067	0.000383304	0.0199045	0.01586529	0.01025024
+1:Del:T:5	3.31e-18	0.814697227	0.008066314	0.000154442	0.030610523	0.007954345	1.92e-07	0.010620342	0.000929835	1.27e-17	0.006539395	0.000348512	0.006079575	0.038616999	0.046903215	2.79e-18	4.63e-08	0.070140562	0.001898312	0.009773246	0.034237057	0.008725468	0.00484058	0.0027324	0.04611943
+1:Ins:C:0	3.31e-18	3.95e-18	0.002083092	6.62e-18	0.000542252	0.002086887	0.000672367	0.002764271	5.41e-18	8.42e-18	0.000186238	1.42e-17	0.002850428	0.454386958	6.58e-18	0.060271337	0.004878118	1e-18	0.016286282	0.001053993	0.000293515	0.005075683	0.00228553	5e-08	0.00112228
+1:Ins:C:1	3.31e-18	0.000227026	0.001578887	0.000272399	0.001242898	0.001773433	2.62e-05	0.002169119	1.93e-06	0.000345074	0.163482884	0.000167697	0.001652256	0.012777431	6.58e-18	0.136484095	0.014767199	0.002004016	0.033050286	0.010880956	0.001473486	0.001550607	0.00057783	0.00118662	0.00494242
+1:Ins:C:2	3.31e-18	2.62e-05	0.001747946	6.88e-05	0.003151667	0.000246169	2.58e-05	0.001527	0.000352623	0.000272059	0.093738843	0.001596586	0.00082125	0.00065885	6.58e-18	0.124683558	0.029260405	1e-18	0.015408145	0.028439758	0.000154396	0.00175219	0.00147472	0.00148604	0.00230421
+1:Ins:C:3	0.000845986	0.00043005	0.006177647	0.000512481	0.000602848	0.000232169	0.002407735	0.000116524	5.41e-18	0.002580556	0.03617564	0.000450319	0.000375555	0.001564403	6.58e-18	0.098883121	0.049254522	1e-18	0.007187529	0.203771492	0.000210735	0.014026027	0.00171284	0.00058833	0.01107799
+1:Ins:C:4	0.001785525	0.002911846	0.007104447	6.62e-18	0.000197582	0.000376592	0.015485431	0.000554177	2.16e-06	0.000411089	0.011189789	0.00439393	0.000148578	0.001539502	6.58e-18	0.062094379	0.024538408	1e-18	0.010283472	0.376913489	0.00047283	0.021103546	0.00010835	0.00207201	0.00302963
+1:Ins:C:5	0.024296536	0.009017536	0.007351101	0.000249143	0.000433544	0.000247997	0.060343229	0.000489489	7.37e-05	0.000851184	0.003412242	0.01705149	0.000706981	0.002292999	6.58e-18	0.031034603	0.009790503	1e-18	0.027969581	0.229282853	0.001820848	0.01139551	0.00126133	0.00072066	0.02183345
+1:Ins:T:0	0.002283824	0.001328556	0.018722365	0.000333665	0.006361965	0.006396251	1.36e-06	0.004507979	0.012614484	0.017003667	0.000406945	0.004265301	0.041137013	0.032612007	6.58e-18	0.030194287	0.004892794	1e-18	0.018089253	0.001320223	0.007152362	0.00331705	0.00623642	0.00133828	0.01448952
+1:Ins:T:1	4.03e-05	3.95e-18	0.043119029	0.001010044	0.013462697	0.001041187	0.000373648	0.004868696	0.010385274	0.043809449	0.314277276	0.002496518	0.004748853	0.003165883	6.58e-18	0.103160227	0.038893641	0.002004016	0.028089646	0.008660094	0.022054862	0.007960156	0.01262155	0.01904617	0.01618837
+1:Ins:T:2	0.000192865	0.000647033	0.04015704	1.06e-05	0.029721144	0.000738848	0.018382706	0.001429636	0.002314663	0.003650787	0.161807823	1.42e-17	0.003054171	0.001774606	6.58e-18	0.108738483	0.043924608	1e-18	0.011563009	0.004854207	0.001713	0.004635919	0.0105721	0.0097759	0.00597962
+1:Ins:T:3	0.004243267	0.001082879	0.025125434	0.000173935	0.01884025	0.000930638	0.008891635	0.001087286	0.001600885	0.003750809	0.107725327	0.000105674	0.009271857	0.001173836	6.58e-18	0.100939445	0.004872091	0.002000008	0.006792575	0.003634998	0.002741801	0.002279392	0.00581943	0.00750924	0.00563053
+1:Ins:T:4	0.016649127	0.003487461	0.006563305	1.6e-05	0.011268752	0.001349852	0.012787969	0.000822618	0.001585355	9.66e-06	0.04903068	0.00033648	0.012098641	0.004784999	6.58e-18	0.051962376	0.004903486	0.008016064	0.006701586	0.00233315	0.000543914	0.000519919	0.00330097	0.00500554	0.00357056
+1:Ins:T:5	0.890906468	0.003132585	0.026181239	0.000832926	0.001439215	0.014390041	0.010789849	0.020161248	0.00577248	1.11e-08	0.023629043	0.00016655	0.011099794	0.232747555	6.58e-18	0.035007686	0.00487383	0.004008032	0.010733883	0.051457761	0.016359294	0.017875614	0.00027934	0.0119619	0.34213643
+2:Del:R:0	0.000686046	0.000163809	0.006897553	0.071724214	0.028054407	0.001783647	2.33e-05	0.008769219	0.013174747	0.000839181	9.08e-18	0.006268105	0.022184399	0.000661996	6.58e-18	0.001922942	0.014682054	1e-18	0.002382332	0.002703211	0.005974766	0.003117327	0.02385067	0.08764835	0.00488513
+2:Del:R:1	0.001219969	0.003568885	0.008474654	0.230512879	0.024562729	0.002454347	0.008182302	0.010307145	0.003198541	0.009472042	0.001363099	0.000278425	0.004333215	0.006600036	6.58e-18	0.002014646	0.008535951	0.036072289	0.001512093	0.002072556	0.058327989	0.001516385	0.05613034	0.02210702	0.01295105
+2:Del:R:2	0.000472749	0.001849574	0.011800641	0.055059396	0.004562618	0.0020886	0.008991541	0.000532026	0.001189697	0.006541411	0.000150729	0.001398167	0.003108924	0.00270193	6.58e-18	0.001116794	1.46e-08	0.002004016	0.004762349	0.000586319	0.008209245	0.000388753	0.02322644	0.00317004	0.00651219
+2:Del:R:3	0.00042672	0.000739044	0.006671125	0.012811006	0.000395919	0.000525746	0.072132138	2.71e-05	9.59e-05	0.00018504	9.08e-18	0.00067331	0.000105566	0.000392799	6.58e-18	0.000472257	3.5e-08	1e-18	0.000529949	0.000255389	0.003128391	0.000434173	0.00668162	0.00053563	0.00184115
+2:Del:R:4	5.46e-05	0.000881932	0.002822525	0.003219218	0.000867563	0.000232527	0.052250842	0.000274027	5.41e-18	8.42e-18	9.13e-06	0.011980739	6.13e-06	1.41e-06	6.58e-18	3.88e-05	4.34e-08	0.002004016	4.58e-05	1.09e-08	0.001925763	0.000737297	0.00180121	2e-08	0.00129842
+2:Del:R:5	3.31e-18	4.67e-18	0.000101239	0.002382721	0.02142678	0.000215685	0.057046331	0.000833079	5.41e-18	8.42e-18	0.004527713	0.251519844	6.63e-05	4.37e-05	6.58e-18	2.64e-18	3.89e-08	1e-18	6.84e-06	1.35e-08	0.002766509	0.001011988	0.00049256	1.256e-05	0.00017077
+3:Del:R:0	0.000128045	1.25e-05	0.000589124	0.005068954	0.01713637	0.001051047	0.000625412	0.010964101	0.002858095	0.001200259	0.000189442	0.007599859	0.003039667	0.001146659	6.58e-18	0.001060141	0.008558573	0.004008032	0.000868076	7.14e-09	0.017130372	0.004391951	0.00495202	0.01987634	0.00085435
+3:Del:R:1	0.005011085	0.005003258	0.000372386	0.097114466	0.005909794	0.005413653	0.011689003	0.001348867	0.00430191	0.042709211	0.000390863	0.000569429	0.001186963	0.004840165	6.58e-18	0.002325923	0.002445446	0.006012048	0.00500577	0.00178089	0.148733688	0.002395167	0.00300516	0.00297375	0.01169181
+3:Del:R:2	0.000769383	0.002289891	9.63e-05	0.021484282	0.00084271	0.000536054	0.005474849	0.000376571	0.001275717	0.005061091	0.000170422	0.002680339	0.000384379	0.001053481	9.35e-05	0.001150375	3.41e-08	1e-18	0.001333068	3.89e-09	0.034572849	0.000318398	0.00049782	8.147e-05	0.00111746
+3:Del:R:3	0.000371256	0.000402587	2.45e-05	0.003837627	0.000621155	4.7e-05	0.003456748	0.000253509	0.00030211	0.002730589	0.000127576	0.005920051	6.9e-05	0.000249605	6.58e-18	0.000120553	1.99e-08	1e-18	3.85e-05	1.66e-08	0.007157176	2.67e-05	0.000104	7.56e-06	2.435e-05
+3:Del:R:4	3.31e-18	3.97e-18	3.82e-06	0.000786295	0.005867075	7.31e-05	0.000492537	2.68e-06	5.41e-18	8.42e-18	0.001202108	0.068622143	3.09e-06	9.19e-18	6.58e-18	1.61e-05	2.13e-08	1e-18	3.81e-05	1.8e-08	0.002464177	2.14e-05	5.494e-05	7.4e-07	6.255e-05
+3:Del:R:5	3.31e-18	3.95e-18	3.83e-07	0.001138609	0.008378911	0.000150616	0.000436589	9.1e-05	5.41e-18	8.42e-18	0.001742363	0.097480944	9.96e-05	9.19e-18	6.58e-18	9.58e-06	4.51e-08	1e-18	0.000118082	2.02e-08	0.001402456	2.34e-05	4.982e-05	9e-07	0.00029702
+4:Del:R:0	9.97e-05	1.21e-05	0.000177645	0.007252429	0.010791265	0.002315098	0.000130877	0.006691309	0.001432774	0.001470317	9.08e-18	0.001734516	0.002155349	0.000193687	6.58e-18	0.000698912	0.006109585	0.004008032	0.002197962	1.05e-08	0.014603366	0.003517587	0.00285339	0.02835941	0.00019409
+4:Del:R:1	0.000900503	0.002115787	0.000634573	0.06352373	0.002843569	0.002806729	0.003396804	0.001622955	0.004594217	0.000521112	0.000355504	0.002302595	2.3e-05	0.000617337	6.58e-18	0.000426296	1.55e-08	0.002004016	7.09e-05	0.00057493	0.114895679	0.00153302	0.00219556	0.01439245	0.00339009
+4:Del:R:2	3.23e-06	0.000543292	0.000116799	0.014548922	0.000164644	0.00047449	0.002777387	0.000272623	0.000896024	7.5e-05	9.08e-18	0.000611679	7.92e-05	0.000524295	6.58e-18	7.83e-05	3.83e-08	1e-18	0.000402692	1.71e-08	0.021881849	0.000657343	0.0001608	0.00480249	0.00092652
+4:Del:R:3	3.31e-18	7.27e-06	4.12e-18	0.004554752	0.003877814	0.000291345	0.000439586	2.88e-05	2.38e-05	0.000132028	0.000312137	0.039259058	3.92e-05	5.03e-05	1.39e-06	2.64e-18	1.46e-08	1e-18	5.99e-05	1.46e-08	0.006887065	2.34e-05	0.00011157	0.00128977	0.00019445
+4:Del:R:4	3.31e-18	3.95e-18	4.12e-18	0.000849679	0.004557254	0.000110576	0.00020181	9.73e-05	5.41e-18	8.42e-18	0.000687366	0.053287873	9.47e-06	7.73e-06	6.58e-18	2.63e-06	3.19e-09	1e-18	0.000194309	2.12e-08	0.002399621	5.32e-06	2.62e-05	3.929e-05	5.655e-05
+4:Del:R:5	2.89e-05	0.000210413	2.83e-06	0.00061078	0.001584436	5.68e-05	0.000250764	6.34e-06	1.37e-05	0.000209045	0.000157603	0.018644449	6.3e-05	9.19e-18	1.76e-06	2.64e-18	4.44e-09	1e-18	0.000157985	2.83e-08	3.31e-05	6.61e-07	1.37e-05	0.00011684	8.06e-06
+5:Del:R:0	8.35e-06	3.85e-05	0.001776785	0.004132826	0.018447949	0.019333291	8.55e-05	0.237978862	0.000772052	0.0013903	0.001281454	0.003382885	0.020097536	0.006086814	0.000284018	0.00556879	0.023396376	0.024048192	0.004262979	0.002181228	0.004533871	0.003146455	0.01685377	0.0103666	0.00340893
+5:Del:R:1	0.000190676	0.002977512	7.41e-05	0.015718533	0.000410335	0.007501825	0.003476729	0.000572257	0.000479551	0.026205652	0.000474634	0.002797035	0.002980534	0.000314462	6.58e-18	0.000110241	1.92e-08	1e-18	0.001770921	3.48e-09	0.025535891	0.000275481	3.437e-05	0.00197004	0.00222752
+5:Del:R:2	0.000126355	0.000397525	2.78e-06	0.002343845	0.000470925	0.000370524	0.0011689	0.000516838	0.000264969	0.001770382	9.08e-18	0.005103842	6.99e-05	2.13e-05	6.58e-18	1.54e-05	4.86e-08	1e-18	0.001018979	1.32e-08	0.002836687	9.75e-06	1.16e-05	0.00041162	0.00037639
+5:Del:R:3	1.89e-05	0.000158151	4.12e-18	0.00118248	0.000257167	0.000168175	0.000406617	8.16e-06	6.12e-06	0.00013703	9.08e-18	0.002200952	6.4e-06	2.85e-05	1.25e-06	6.73e-06	3.43e-08	1e-18	0.000126375	1.99e-08	0.000854605	3.69e-06	7.67e-06	3.606e-05	0.0002506
+5:Del:R:4	3.11e-06	8.47e-05	4.37e-05	0.000146923	9.73e-05	5.32e-05	0.000125882	0.000112898	7.25e-06	0.000125027	9.08e-18	0.001256186	1.46e-06	1.5e-05	6.58e-18	2.67e-07	9.21e-09	1e-18	2.24e-06	3.09e-08	5.26e-07	2.96e-08	3.031e-05	1.848e-05	2.075e-05
+5:Del:R:5	3.13e-05	2.12e-05	3.82e-06	0.000106174	0.000585018	1.15e-05	2.08e-05	4.43e-05	2.99e-05	0.001120242	8.18e-08	0.00618126	2.35e-06	9.08e-05	1.74e-06	2.63e-18	3.34e-08	1e-18	2.24e-06	3.09e-08	5.26e-07	2.96e-08	1.6e-06	8e-08	5.207e-05
+2:Ins:R:0	0.000402036	0.000331853	0.00263595	0.000492922	0.006349454	0.001998387	3.04e-05	0.00191671	0.001162339	0.025305458	0.000190467	0.007440331	0.010618411	0.023942256	6.58e-18	0.002191793	0.034379414	1e-18	0.078270263	0.000557266	4.81e-05	0.005366029	0.00376734	0.00353797	0.00720895
+2:Ins:R:1	7.88e-06	0.000271665	0.002242683	0.000553302	0.018387642	0.000208533	0.000397626	0.001661816	0.002100192	0.038908392	9.08e-18	0.001062301	0.001801368	0.000123773	6.58e-18	0.001087848	0.058508649	1e-18	0.02359708	0.000609208	0.005076259	0.030684627	0.00326139	0.00813213	0.00203569
+2:Ins:R:2	0.000221347	0.001035341	0.000955604	0.000266335	0.007207952	0.000790414	7.01e-05	0.000304586	0.000760941	0.026205652	0.000247885	0.000550238	0.000688524	0.001114199	6.58e-18	0.000729932	0.063694193	1e-18	0.003639604	0.002345574	0.000222987	0.008888139	0.00154666	0.00049856	0.00064392
+2:Ins:R:3	0.000514268	0.000381326	0.000897238	0.000137794	0.001172292	0.000499074	0.003147039	0.000177583	0.000351635	0.00028006	0.000372356	0.000165525	0.000743544	0.000871483	6.58e-18	9.48e-05	0.009762713	0.002004016	0.001183172	0.000374507	0.001080992	0.005774136	0.00024006	0.00106105	0.00035493
+2:Ins:R:4	0.0029131	0.001977423	0.000253085	7.19e-05	6.88e-05	0.000189469	0.00182828	1.66e-05	3.07e-05	8.42e-18	0.000442384	0.001018206	0.000213354	0.002973978	6.58e-18	0.000131664	3.84e-09	1e-18	0.003802592	1.02e-08	0.001769329	0.000922912	0.00022169	0.00097089	0.00088684
+2:Ins:R:5	0.018121584	0.013633376	6.67e-06	0.000103689	0.000994122	0.000748642	0.00024477	0.001764384	5.41e-18	8.42e-18	0.000288801	0.038005197	0.000846575	0.000544275	6.58e-18	1.18e-06	4.64e-08	0.002004016	0.033275223	0.00103185	0.014259815	0.001554575	2.59e-06	0.0018288	0.01049181
+3:Ins:R:0	3.06e-07	5.78e-05	9.6e-05	2.63e-05	0.003792478	0.001219185	1e-18	0.000667863	0.000254573	0.018103905	9.08e-18	0.01515014	8.21e-05	0.006623497	6.58e-18	0.000570589	0.019583137	0.004008032	0.05448195	9.66e-09	0.001592806	0.08662352	0.00077334	0.00161158	0.00382815
+3:Ins:R:1	0.000254695	0.00122705	0.000286144	0.000450983	0.006122761	0.000288615	5.51e-06	0.000671723	0.000823355	0.055211908	0.000207083	0.000869573	0.003688328	0.0025232	6.58e-18	0.001092184	0.112273274	1e-18	0.005101451	0.000529852	1.15e-06	0.231492523	0.00152975	0.00439696	0.0002876
+3:Ins:R:2	4.41e-05	0.000210075	9.75e-05	0.000600335	0.001143468	0.000746533	5.47e-05	0.000135768	0.000118261	0.009432034	0.000221526	0.000183891	0.000202511	0.000204501	6.58e-18	0.000281271	0.038874479	1e-18	0.001262601	1.34e-08	0.001417047	0.011918844	4.958e-05	0.00239573	0.00059532
+3:Ins:R:3	0.000166702	3.02e-06	1.36e-05	7.42e-05	1.02e-05	0.000249737	0.000177833	3.79e-05	5.18e-06	0.000461099	2.18e-05	8.7e-05	2.37e-05	0.000327493	6.58e-18	3.18e-05	1.39e-08	1e-18	0.000566956	2.05e-08	5.85e-05	0.000155001	4.653e-05	8.289e-05	0.00017021
+3:Ins:R:4	8.89e-05	0.000141807	1.56e-06	7.4e-05	1.18e-05	0.000155952	0.000415609	0.000122041	1.61e-05	0.00018704	9.08e-18	0.000340788	3.49e-06	0.00060186	6.58e-18	7.56e-05	2.84e-08	1e-18	0.000201184	2.28e-08	0.000149896	1.42e-05	1.575e-05	0.00010134	0.00011381
+3:Ins:R:5	0.001248696	0.001864707	4.12e-18	3.96e-05	0.000102574	1.98e-05	0.000769276	3.66e-05	5.41e-18	0.00018504	9.01e-05	0.002840312	3.54e-05	0.002205997	6.58e-18	2.29e-05	2.78e-08	1e-18	0.00101487	1.7e-08	0.000743075	2.8e-05	1.267e-05	0.00024554	0.00253638
+4:Ins:R:0	3.31e-18	1.68e-05	4.12e-18	0.000166645	0.002439186	0.001467917	1e-18	0.000777758	0.000164387	0.016003452	0.000159621	0.005701178	0.001118797	0.00594693	6.58e-18	0.00032756	0.014692452	1e-18	0.049751651	1.48e-08	6.49e-06	0.212742408	0.00052016	0.00054899	0.00309713
+4:Ins:R:1	0.000744381	0.001203728	0.000175982	0.001266435	0.003612298	0.000476283	2.61e-05	0.001103901	0.000715565	0.074616092	0.000377636	0.001908886	0.002691635	0.001326926	6.58e-18	0.001506978	0.210245111	0.002004016	0.001479678	0.000378074	0.000508317	0.217852954	0.00136458	0.00571956	0.00213109
+4:Ins:R:2	7.55e-05	1.22e-05	2.74e-05	9.84e-05	0.000376459	0.000528663	0.000194817	7.99e-05	4.24e-05	0.004090882	9.08e-18	0.00021849	6.93e-05	8.45e-05	6.58e-18	4.5e-05	0.009749097	1e-18	0.001017378	1.53e-08	0.000663976	0.0036275	0.0003998	0.00034975	0.00011109
+4:Ins:R:3	0.000157544	0.000134169	4.77e-05	5.25e-05	1.87e-06	0.000334824	0.000273742	8.58e-06	2.15e-05	0.000239052	9.08e-18	0.000176569	6.39e-07	0.000713852	1.36e-06	3.02e-07	1.86e-08	1e-18	0.000309935	2.04e-08	0.000335185	2.39e-05	4.79e-06	8.665e-05	1.627e-05
+4:Ins:R:4	0.000319653	0.000249385	4.18e-06	0.000146911	6.41e-06	5.6e-05	0.000258757	0.000205515	5.41e-18	0.002280492	9.08e-18	0.000636053	1.21e-05	0.00166501	1.45e-06	9.4e-06	9.68e-09	1e-18	0.001528572	1.45e-08	0.000322588	5.71e-06	3.082e-05	0.00077134	0.00043988
+4:Ins:R:5	0.00100132	0.002193545	3.29e-05	0.000135205	0.000635977	0.000106861	8.74e-06	0.000885225	2.18e-06	0.013802977	9.08e-18	0.011670537	3.14e-07	0.000274449	6.58e-18	2.66e-18	1.17e-08	1e-18	1.22e-07	2.6e-08	0.00056024	0.000180119	7.19e-06	0.00146458	0.00070282
+5:Ins:R:0	3.31e-18	3.95e-18	8.83e-05	8.58e-05	0.004750071	0.008716781	1e-18	0.000318329	0.000165846	0.049210613	0.00066606	0.013790645	0.002590231	0.002712141	6.58e-18	0.001172587	0.014673882	0.012024096	0.336651799	0.000906095	0.004929548	0.014950647	0.00072143	0.00310967	0.0004728
+5:Ins:R:1	0.001443126	0.000135658	0.00065622	0.002135852	0.004793431	0.005405643	1e-18	0.009761114	0.001253996	0.278059972	0.00115191	0.003834265	0.013501952	0.026455525	6.58e-18	0.001101192	0.004919532	0.002004016	0.008432312	0.003178667	0.01709467	0.004733335	0.00229238	0.02152458	1.324e-05
+5:Ins:R:2	0.000254832	5.53e-06	5.51e-06	0.000222027	0.000298796	0.001321843	8.84e-06	0.000101153	0.000102849	0.009221989	0.000366007	0.002130016	4.59e-05	0.000488313	1.18e-06	8.28e-07	4.64e-08	1e-18	0.000246442	3.15e-09	0.000693116	1.81e-05	0.00021296	0.00033879	5.698e-05
+5:Ins:R:3	0.000237087	9.77e-05	3.32e-05	7.59e-06	0.000165546	2.88e-05	4.46e-06	7.09e-05	8.02e-05	0.003660789	8.34e-07	0.002660489	4.61e-05	0.000103831	1.62e-06	2.66e-18	4.76e-08	1e-18	0.001737586	2.11e-08	0.00015937	0.000195338	3.02e-06	0.00017981	0.00021686
+5:Ins:R:4	0.000261865	2.15e-06	7.87e-06	2.53e-05	0.000126707	4.83e-05	1.06e-05	6.74e-06	5.05e-05	0.00334072	2.25e-06	0.001592407	2.43e-06	0.000157593	6.58e-18	2.66e-18	3.96e-08	1e-18	0.000165085	2.69e-08	2.51e-05	1.51e-06	5.035e-05	6.68e-06	1.411e-05
+5:Ins:R:5	0.000119834	0.000115629	3.48e-06	0.000160229	0.000626342	6.17e-05	4.28e-06	0.000190551	9.89e-06	0.002740591	1.84e-06	0.00613607	4.33e-05	2.15e-05	6.58e-18	2.65e-18	4.48e-08	1e-18	2.24e-06	3.09e-08	7.07e-06	3.42e-05	2.6e-06	2.184e-05	0.00012446
+2:Del:M:1	0.001197815	0.000175553	0.006930764	0.188997489	0.028687946	0.000632866	0.003127058	0.004913672	0.003900972	0.000638138	0.000382064	0.002653503	0.008872408	0.002640925	6.58e-18	0.001374201	0.003668966	0.018036144	0.002361922	0.001885514	0.01183853	0.001744942	0.03953384	0.15468429	0.00906527
+3:Del:M:1	8.19e-05	5.46e-07	0.000344612	0.007034156	0.013157147	0.000990097	0.00025476	0.009290337	0.003011328	0.003960854	0.000200443	0.010328352	0.001140083	0.001575173	6.58e-18	0.00076447	0.004887304	1e-18	0.000142903	0.00051866	0.016456594	0.003256536	0.00210806	0.02477473	0.00239704
+3:Del:M:2	0.001479593	0.002944063	0.00030285	0.049416601	0.00900421	0.00443363	0.004635639	0.004302693	0.001543302	0.019304164	0.000301744	0.006061158	0.000450306	0.003236935	6.58e-18	0.000980364	0.003681076	1e-18	0.001188445	0.000572256	0.076342425	0.001382468	0.00445127	0.09408264	0.00758805
+4:Del:M:1	8.38e-05	0.000147005	7.35e-05	0.010981719	0.008732202	0.002745395	0.000183827	0.005809551	0.001927721	0.000179039	9.08e-18	0.003771718	0.001270798	8.2e-06	6.58e-18	0.000504718	0.010979731	0.006012048	0.001230367	0.000443206	0.021683163	0.003828183	0.00334573	0.03151639	0.00191716
+4:Del:M:2	0.000145479	0.000550614	0.000340216	0.029483877	0.006047187	0.00868271	0.001019041	0.001591587	0.003297448	0.000387083	9.08e-18	0.004573153	0.000159723	0.000950493	6.58e-18	0.0004098	0.004890442	1e-18	0.00011789	0.000510533	0.055939003	0.001748172	0.00271152	0.09014531	0.0028055
+4:Del:M:3	0.000160684	0.000693566	0.000130463	0.04886664	0.003442442	0.004773094	0.000717325	0.001098342	0.002544079	8.22e-05	0.000789868	0.000525263	0.000270578	0.002230434	6.58e-18	0.000402368	0.003659617	1e-18	0.000412019	0.000464372	0.078494647	0.00012253	0.00175756	0.15521228	0.0014924
+5:Del:M:1	8.16e-07	0.000624963	0.001369634	0.000453121	0.008617073	0.071066579	2.36e-05	0.28072426	3.54e-05	0.001330287	0.000282794	0.000563378	0.011740777	0.006551706	0.000660877	0.005362049	0.020771328	0.030060241	7.27e-05	0.002936567	0.000651791	0.0015615	0.01006779	0.00623417	0.00359075
+5:Del:M:2	2.38e-10	0.000117708	0.001751272	0.000136232	0.007851021	0.253108348	0.000245769	0.123610163	0.000221236	0.000124027	0.000372771	1.42e-17	0.007055421	0.004498634	0.000432409	0.005021715	0.012290058	0.022044176	0.000690739	0.003399086	3.07e-05	0.000334283	0.00828299	0.00047324	0.00329719
+5:Del:M:3	2.33e-12	5.67e-05	0.000774958	0.001112236	0.007157975	0.216806033	6.16e-05	0.046130408	0.000570907	5.65e-05	0.000750127	0.000323568	0.002165984	0.001404487	0.000266126	0.00333884	0.008596258	0.006012048	0.000617644	0.001452413	0.000222529	0.001072803	0.00336542	0.01166155	0.00023289
+5:Del:M:4	3.88e-05	0.000462842	0.000640555	0.003652946	0.002492549	0.120483943	6.82e-05	0.016367256	0.000448308	0.000104022	0.000130278	0.000277663	0.000281736	0.000100143	0.000247928	0.001329897	0.004897913	0.004008032	5.32e-05	0.001219253	0.003589866	8.76e-05	0.00213513	0.01362695	0.00015915
+5:Del:M:5	0.000665116	0.002367319	0.00036297	4.56e-05	0.001112367	0.099282999	0.001738365	0.012814882	5.41e-18	0.041408931	0.000518955	0.006657973	0.013131907	0.000931512	0.000139829	0.001601629	0.006075636	1e-18	0.003317459	1.83e-09	0.003415398	0.001031553	0.00074925	0.00258631	0.00221017